Clinical Digest: Recent Clinical Trials on Asthma
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Asthma. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Asthma
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Improving Chronic Disease Outcomes Across The Lifespan By Addressing Structural Racism PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in primary care settings can lead to a meaningful decrease in chronic disease by monitoring conditions such as hypertension, diabetes, depression, hyperlipidemia, and asthma through clinical measures. The main question it aims to answer is: Does the WE CARE SDOH screening and referral intervention applying an antiracism lens informed implementation strategies have the potential to reduce racial/ethnic health inequities in chronic diseases for minoritized patients? |
ARVIN GARG; | 2025-05-01 |
| 2 | Measuring Whether Promotion of A Digital Social Intervention By Primary Care Healthcare Professionals and Subsequent Engagement With Online Peer Support Improves Health and Well-being of Patients With Asthma and Is Cost-effective: A Randomised Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to deliver a definitive randomised controlled trial to measure the effectiveness and assess cost-effectiveness of a digital social intervention for patients with asthma, composed of promoting engagement with online peer support in a primary care consultation, followed by engagement with online peer support for 12 months. The main questions/objectives this study aims to answer/address are: * Does promoting engagement with an online health community in primary care help people with troublesome asthma to experience fewer asthma symptoms? * To assess cost-effectiveness of the intervention (including quality of life, well-being, use of healthcare services etc); … |
ANNA DE SIMONI; | 2025-05-01 |
| 3 | A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Trial to Evaluate The Efficacy and Safety of Rademikibart As An Add-on Treatment for Acute Exacerbation in Adult and Adolescent Participants With Asthma and Type 2 Inflammation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2, randomized, multicenter study in adult and adolescent participants with asthma and type 2 inflammation |
CONNECT BIOPHARM | 2025-05-01 |
| 4 | A Randomized Control Trial of A Supervised Peanut Feeding Clinic to Increase Early Peanut Introduction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Peanut allergies affect approximately 2.5% of children; are associated with significant mortality, morbidity, and economic costs; and often lead to persistent peanut allergies in adulthood. We now know however that early introduction of peanut products to infants prior to age 7 months and maintained in the diet regularly significantly reduces the rate of peanut allergies. Unfortunately, recent research shows that even when parents know the recommendations to feed peanut products early and often, \<50% of parents report introducing peanuts by age 9 months, \<45% are offering peanut products several times a week, ... |
CORINNA REA; | 2025-05-01 |
| 5 | Senicapoc in Patients With Progressive Fibrotic ILD (Interstitial Lung Disease) and IPF (Idiopathic Pulmonary Fibrosis) to Prevent Progression PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate whether the drug called senicapoc can prevent worsening of the scarring in interstitial lung disease. Researchers will compare senicapoc to a placebo (a look-alike substance that contains no drug) to see if senicapoc works to prevent lung function worsening Participants will be asked to take 3 tablets a day for a period of 26 weeks. Within this period doctors will follow the participants, ask for experience of adverse events, check lung function and organ status, and participants will need to fill out quality-of-life questionnaires. A total of 3 visits is required, at initiation, … |
VEJLE HOSPITAL | 2025-05-01 |
| 6 | Effect of Aquatic Exercises on Muscle Strength and Quality of Life in Children With Sickle Cell Anemia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sickle cell anemia is a global public health disorder that affects millions of people across the globe. It is an inherited autosomal recessive hemoglobin condition caused by a beta-globin gene mutation that results in an aberrant sickle cell hemoglobin molecule with glutamic acid replaced by valine at position six of the beta-globin chain. Sickle cell anemia is a hereditary illness characterized by persistent microvascular blockage by sickle-shaped cells, chronic hemolytic anemia, and tissue destruction. Red-cell dehydration, hypoxemia, metabolic acidosis, and hyperthermia are typical vaso-occlusive triggers. Children with sickle cell anemia frequently have poor growth and nutritional status, increased protein turnover, … |
EMAN SAMIR SHALTOUT; | 2025-05-01 |
| 7 | A 52-week, Multicentre, Observational, Prospective Study on The Use of A Smart Platform Connected to A Single-inhaler Triple Therapy (ICS/LABA/LAMA) to Evaluate Effectiveness on Treatment Adherence and Inhaler Technique in Patients with Poorly Controlled Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to determine if using the SiA® (Systematic Intervention Agent) system can improve inhaler technique and medication adherence in adults with asthma who are already using Trimbow pMDI inhalers. Furthermore, it will be addressed if the SiA® system can be used to discriminate between patients, … |
JOHANNES M SCHMID; | 2025-05-01 |
| 8 | Investigation of Factors That May Affect Headache in Individuals with Juvenile Onset Systemic Lupus Erythematosus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of our study was to compare individuals with juvenile onset systemic lupus erythematosus with and without headache in terms of pain, pain catastrophizing behavior, demographic and individual disease-related factors that may affect headache and temporomandibular joint dysfunction. |
ZÜLAL TATAR; | 2025-04-24 |
| 9 | Chronic Airway Inflammation: The Impact of Respiratory Microbiota, Infection Characteristics, and Imaging Features on Disease Progression and Quality of Life-A Multomic and Comprehensive Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study，Respiratory microbiota, infection characteristics and imaging manifestations in patients with chronic airway inflammation， adopted a prospective, observational, multi-omics study design to comprehensively evaluate the effects of respiratory microbiota, infection characteristics and imaging manifestations on disease outcomes and quality of life in patients with chronic airway inflammation. Involving six parallel sub-studies, These include: (1) the differences and mechanisms of lung microecology in ICS treatment sensitivity and resistance in patients with chronic airway inflammation, (2) the study of respiratory viral infection and inflammatory markers in patients with acute exacerbation of chronic obstructive pulmonary disease, … |
FIRST AFFILIATED HOSPITAL OF NINGBO UNIVERSITY | 2025-04-15 |
| 10 | Tezepelumab in The Treatment of Emergency Room Asthma in Adults (TERAA): A Phase 4 Double-Blinded, Parallel-Group, Randomized Control Trial With An Open Label Extension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Adults with severe asthma may have sudden worsening shortness of breath that results in their going to Emergency Department for urgent care. Emergency Room visits for asthma management across Alberta have been reviewed and it has been found that adults frequently need to return for repeated worsening. This is a large drain on health care resources as well as being very distressing for individuals with asthma. Occasionally this results in admission to hospital and rarely may lead to death. People are often treated with steroids to try to prevent the need for Emergency Room visits even though steroid medications have many long term bad side effects. A new medication for patients considered to have severe asthma has been recently approved by Health Canada. This medication, Tezepelumab, is a monthly injection and it helps control asthma in adults regardless of the underlying cause. The study will examine if starting Tezepelumab, compared with a placebo, in the Emergency Room will help settle symptoms of asthma and prevent future worsening requiring repeated Emergency Room visits or the need for courses of outpatient steroid medications. |
IRVIN MAYERS; | 2025-04-15 |
| 11 | Can The Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify The Decrease in HbA1c and Prevent The Increase in Plasma Ketone Concentration? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Previous data from our clinical trial has demonstrated that the combination of dapagliflozin plus pioglitazone cause robust decrease in the plasma glucose concentration without significant increase in plasma ketone concentration in subjects with T1DM receiving multiple insulin injections or insulin pump. Although patients receiving insulin therapy with pump have participated in the study, none has insulin delivered in automated pump (780 pump) which automatically adjusts the rate of insulin infusion based upon the measured plasma glucose concentration. Although automated insulin pumps have been introduced to practice only last year, … |
MUHAMMED ABDUL GHANI; | 2025-04-15 |
| 12 | A Phase IIb, Multicentre, Double-blind, Placebo-controlled Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adult Participants With Uncontrolled Asthma on Medium-to High Dose Inhaled Corticosteroids PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a dose-range finding, double-blind, placebo-controlled, phase IIb study designed to assess efficacy and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving medium-to-high dose inhaled corticosteroids. |
ASTRAZENECA | 2025-04-10 |
| 13 | Observation of Inhalation of CXMCI-01 Essential Oil on Patients With Mild Cognitive Impairment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Memory declined and cognitive impairment are common complaints in neurology clinics. Before diagnosing as dementia, individuals will undergo a transition period, including mild cognitive impairment (MCI). Neuroinflammation is an important mechanism of memory problems. For patients with MCI, there are limited available medications. Currently, there is no standardized treatment in Taiwan. The purpose of this study is to explore alternative treatment with essential oil by inhalation to improve memory, sleep, mood, and quality of life for patients with MCI. This study will include patients who are clinically diagnosed as MCI by a neurologist. This is a double-blind randomized controlled trial, … |
YU-HUEI LIU; | 2025-04-07 |
| 14 | Functional Efficiency, Respiratory Parameters and Blood Rheological Tests in Elderly People With Respiratory Diseases Participating in Pulmonary Rehabilitation in Underground Salt Chambers – A Prospective Experimental Study, Controlled in A Crossover Design PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to assess the impact of the rehabilitation and treatment stay at the underground Health Resort of the ‘Wieliczka’ Salt Mine in Wieliczka on the functional capacity, respiratory parameters, and rheological properties of blood in elderly individuals with respiratory diseases. |
UNIVERSITY SCHOOL OF PHYSICAL EDUCATION KRAKOW POLAND | 2025-04-04 |
| 15 | Conducting A Randomized Controlled Trial for A Novel Patient-Facing Mobile Platform to Collect and Implement Patient-Reported Outcomes and Voice Biomarkers in Underserved Adult Patients With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to conduct a randomized controlled trial (RCT) to compare the adapted and refined ASTHMAXcel Voice platform to usual care (UC). It is hypothesized by the investigator team that ASTHMAXcel Voice will be associated with improved clinical and process outcomes, asthma quality of life (QOL), medication adherence, and self-efficacy as compared to UC. |
SUNIT JARIWALA; | 2025-04-01 |
| 16 | Reuseable Face Masks to Reduce Risk of Viral Respiratory Infections and Exacerbations in Adults With Asthma: A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: REMASK trial is a Trial within Cohort study (TwiCs), nested within the COVIDENCE UK longitudinal study. It has been designed to determine whether the offer of a free reusable, elastomeric face mask to adults with asthma and other members of their household reduces risk of RT-PCR confirmed viral respiratory infections and asthma exacerbations. |
ADRIAN R MARTINEAU; | 2025-04-01 |
| 17 | Effect of Pediatric Lung Ultrasound on Antibiotic Prescriptions in Hospitalized Children and Adolescents With Lower Respiratory Tract Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Title: Effect of Pediatric Lung Ultrasound on Antibiotic Prescriptions in Hospitalized Children and Adolescents with Lower Respiratory Tract Infections (PLUS-AP Trial) Purpose of the Study: This study is being done to find out if a type of imaging called lung ultrasound (LUS) can help doctors decide when to stop antibiotics in children and teens who are in the hospital with lung infections, like pneumonia. Antibiotics are often given to these patients, but sometimes they are used for longer than necessary, … |
AMERICAN UNIVERSITY OF BEIRUT MEDICAL CENTER | 2025-04-01 |
| 18 | Exploring Inflammatory and Regulatory Eosinophil Subpopulations: The Path to Precision Medicine for The Treatment of Eosinophilic-associated Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This single-center, non-commercial study will involve 160 participants (80 with eosinophilic asthma (EA), 30 with eosinophilic granulomatosis with polyangiitis (EGPA), 25 with hypereosinophilic syndrome (HES), and 25 healthy donors) to investigate eosinophil subpopulations in these diseases. The study will run from Q4 2024 to Q4 2026. Objectives: Primary: To verify two eosinophil subpopulations (iEos and rEos) in EGPA and HES and analyze the role of type 2 cytokines on their plasticity. Secondary: Compare iEos proportion between different eosinophilic diseases and correlate with disease severity. Exploratory: Assess the effect of mepolizumab on eosinophil subpopulations in vitro. Population: Adults aged 18-75 with EA, EGPA, or HES, and healthy controls. EA patients must have \>300 eosinophils/mcL, EGPA requires asthma + eosinophilia + other specific features, and HES requires high eosinophil counts (\>1500 cells/mL). Methods: Data will be analyzed using Mann-Whitney U, ANOVA, and Spearman correlation tests, with results presented as mean ± SEM. This study will help explore eosinophil behavior in eosinophilic diseases and evaluate mepolizumab’s effects on these cells. |
ALESSANDRA VULTAGGIO; | 2025-04-01 |
| 19 | Epidemiology of Non- Invasive Mechanical Ventilation in Argentina: A Multicenter Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction Non-invasive mechanical ventilation (NIMV) is a fundamental strategy in the management of acute respiratory failure, preventing intubation and reducing complications. However, the epidemiology of its use in Argentina is not well understood, motivating this study. Justification Unequal access to ICU resources in Argentina affects the quality of care. This study aims to describe the implementation, effectiveness, and outcomes of NIMV across different regions of the country to improve clinical decision-making and healthcare policies. Objectives * Primary: Analyze the survival of ICU patients receiving NIMV. * Secondary: Evaluate success/failure factors, regional disparities in resource availability, … |
GUSTAVO PLOTNIKOW; | 2025-04-01 |
| 20 | To Evaluate The Efficacy and Safety of SHR-4597 Inhalants in Adults With Asthma: A Multicenter, Randomized, Open-label, Positive-controlled Phase II Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View |
FENGMING LUO; | 2025-04-01 |
| 21 | Usefulness of Oscillometry in Assessing The Effectiveness of Inhaled Corticosteroides in Patients With COPD Exacerbator Phenotype PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this observational study is to determine the effectiveness of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) and frequent worsening of their respiratory symptoms by using a device called an oscillometer. This instrument is capable of measuring bronchial obstruction and air trapping in the lungs through vibrations during normal breathing. The main question it seeks to answer is: Could oscillometry be useful in assessing the effectiveness of inhaled corticosteroids in patients with COPD exacerbations, … |
YULIANA PASCUAL GONZÁLEZ; | 2025-04-01 |
| 22 | Clinical Evaluation of Montelukast on Cognitive and Mood Dysfunction and Neuroinflammation in Veterans with Gulf War Illness (GWI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study addresses the pre-clinical promise of Montelukast (MLK) for improving brain function in veterans with Gulf War Illness (GWI). MLK, a US Food and Drug administration (FDA)-approved drug for asthma, has shown efficacy in an animal model of GWI to improve cognitive and mood function through modulation of leukotriene signaling and suppression of neuroinflammation. |
DREW HELMER; | 2025-04-01 |
| 23 | The Research on The Role of Human Chorionic Gonadotropin (HCG) Activation in Vivo on The Dormant Follicles in Patients With Premature Ovarian Insufficiency (POI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to activate dormant follicles in patients with premature ovarian insufficiency by injecting human chorionic gonadotropin (hCG) to explore the feasibility of a treatment plan that stimulates the growth of dormant follicles, not visible to the naked eye, to antral follicles visible under ultrasound, without visible follicle growth. The project also seeks to enable patients to conceive offspring carrying their own genetic material through in vitro fertilization (IVF) technology. |
XIAO CHEN; | 2025-04-01 |
| 24 | InternatioNal SeVerE CRSwNP Registry (INVENT) 2024-2028 PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to collect real-life data worldwide, which already have been collected in national databases, to merge the data and the knowledge with the focus of better care for the individual patients, more efficient use of the hospital cost of biologics and working for personalized medicine. |
VIBEKE BACKER; | 2025-03-31 |
| 25 | A Novel MHealth Intervention to Improve Outcomes of Children with Medical Complexity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Children with medical complexity (CMC) are the most vulnerable of children with chronic diseases, who have complex, multisystem chronic diseases affecting ≥3 organ systems, severe functional limitations and technology dependencies. CMC have high health care needs, and account for 40% of hospitalized children and 35% of all pediatric health care costs. Due to high medical fragility, CMC have frequent acute deteriorations superimposed on their chronic conditions, leading to recurrent emergency department (ED)/hospital admissions and affecting quality of life (QOL). To reduce ED/hospital admissions for CMC, remote monitoring is suggested, … |
FLORY NKOY; | 2025-03-31 |
| 26 | Study on The Lung Aerosol Deposition of Ultrasonic Rock Salt Inhalation Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the in vitro modeling phase, the investigators plan to use a realistic human upper respiratory tract model and an asymmetric ideal bronchial tree model. By combining 3D printing experiments with CFD simulations, the investigators will investigate the respiratory tract deposition rate and distribution of micro – moist particles in ultrasound rock salt aerosol inhalation therapy. This will be compared with a small – volume nebulizer to verify the effectiveness of ultrasound rock salt aerosol inhalation therapy and lay the foundation for further research on the application of this inhalation technique to other drug formulations. In the clinical phase, … |
JINGEN XIA; | 2025-03-31 |
| 27 | BRISOTE: A Multicentre, Randomised, Double-Blind, Parallel Group, Active-Controlled, Phase 3b Study to Evaluate The Efficacy and Safety of Benralizumab 30 Mg SC in Eosinophilic Asthma Patients Uncontrolled on Medium-Dose Inhaled Corticosteroid Plus Long-acting Β2-Agonist PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the efficacy and safety of benralizumab as an add-on therapy in uncontrolled eosinophilic asthma participants treated with medium-dose ICS-LABA compared to the conventional treatment step of escalation of inhaled therapy to high-dose ICS-LABA. |
SANDEEP BANSAL; | 2025-03-28 |
| 28 | A Phase 1b, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Immunogenicity of APG777 in Adults With Mild-to-Moderate Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and immunogenicity of APG777 in adult participants with mild-to-moderate asthma. The duration of the study will be approximately 52 weeks (364 days) for each participant and will consist of a Screening Period, Treatment Period, and Follow-up Period. |
APOGEE THERAPEUTICS | 2025-03-27 |
| 29 | A Phase IIb, Multicentre, Double-blind, Placebo-controlled Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adult Participants With Uncontrolled Asthma on Medium-to High Dose Inhaled Corticosteroids PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a dose-range finding, double-blind, placebo-controlled, phase IIb study designed to assess efficacy and safety of tozorakimab administered subcutaneously in adult participants with uncontrolled asthma receiving medium-to-high dose inhaled corticosteroids. |
ASTRAZENECA | 2025-03-26 |
| 30 | A Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial of The Efficacy and Safety of MG-K10 Humanized Monoclonal Antibody Injection in Adolescent and Adult Patients With Moderate-to-Severe Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, double-blind, placebo-controlled Phase III clinical trial on the efficacy and safety of MG-K10 humanized monoclonal antibody injection in adolescent and adult patients with moderate to severe asthma. |
SHANGHAI MABGEEK BIOTECH | 2025-03-25 |
| 31 | The New Zealand Quit Vaping Trial: Combination Nicotine Replacement Therapy Versus Nicotine Reduction PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This research focuses on maximizing the chances of successfully quitting vaping. A large, pragmatic community-based clinical trial is planned in New Zealand to build on existing evidence from previous vaping and smoking cessation research undertaken by the study team. The effectiveness of combination nicotine replacement therapy (NRT) compared to nicotine tapering on vaping abstinence has not yet been investigated, but both provide an opportunity to increase success with vaping cessation, especially when combined with written behavioural support to further boost quit rates. The planned trial will test whether using combination NRT will help more New Zealanders to quit vaping long-term, … |
GEORGE LAKING; | 2025-03-25 |
| 32 | Impact of Sarcopenia on Dyspnea in Patients with Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown. Sarcopenic asthma had a reduced physical activity and is associated with airway obstruction compared to non-sarcopenic asthma. In patients with obstructive pulmonary disease, … |
CAMILLE ROLLAND-DEBORD; | 2025-03-25 |
| 33 | Effects of Virtual Reality Training on Balance and Fall Risk of Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine whether Virtual Reality (VR) training has significant effects on balance and fall risk of patients with COPD, with a focus on the patient group (GOLD STANDARD I \& II). Additionally, the study determines whether VR training is a reliable substitute for traditional physical therapy balance. |
SUMAN SHERAZ; | 2025-03-25 |
| 34 | Navigating Together for Equitable Asthma Management for Children in Families Who Communicate in Languages Other Than English (Nav-TEAM) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The Nav-Team study reviews how well the asthma navigators/coordinator program can improve the lives of asthmatic children, and their caregivers, by providing additional assistance and education. Aim 1 of the study will partner with immigrant serving community organizations to hold meetings that will help tailor the programs. Aim 2 of the study looks at data to help see if the program is working to help children and their caregivers. Aim 2a looks at difference in emergency department use between families that did not use the Nav-Team program and those that did. Aim 2b reviews how well the Nav-Team program did with reaching and connecting with the asthma child and caregiver community. Aim 2b, also reviews the costs of the program, how well the program did will sticking to the program goals, and how well the staff was able to keep up with providing education and help. |
UNIVERSITY OF COLORADO DENVER | 2025-03-21 |
| 35 | A Multicenter, Randomized, Double-blind, Placebo-Controlled Phase III Clinical Trial to Evaluate The Efficacy and Safety of TQC2731 Injections in Patients With Poorly Controlled Severe Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial designed to evaluate the efficacy and safety of TQC2731 injection (420 mg Q4W) in adult subjects with inadequately controlled severe asthma. A total of 660 subjects are expected to be enrolled, with subjects randomized in a 1:1 ratio to receive either TQC2731 (420 mg Q4W) or placebo (Q4W) via subcutaneous (SC) administration. |
SHANGHAI CHIA TAI TIANQING PHARMACEUTICAL TECHNOLOGY DEVELOPMENT | 2025-03-21 |
| 36 | The Pharmacist Led Educational Interventions Through Telemedicine to Improve Asthma Control: A Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to evaluate the impact of pharmacist led educational interventions on Asthmatic patients, and also determine their medication adherence. Pharmacist’s intervention aims to answer: 1. How a pharmacist intervention program impact medication adherence in persistent asthma? 2. To assess how pharmacist led educational intervention like patients’ counseling and medication reminders through Telemedicine have an impact on patient’s asthma control? 3. Which mode of communication (Verbal instructions, videos and pamphlets) for the patient counselling is most beneficial for the patients in asthma control. |
MUHAMMAD ABUBAKAR; | 2025-03-20 |
| 37 | A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial on The Treatment of Bronchial Asthma With Budesonide Formoterol Combined With Immune Modulators (Staphylococcus and Neisseria Tablets) PF:3 Related Papers Related Patents Related Grants Related Experts View Abstract: This study is a randomized, double-blind, placebo-controlled, multicenter clinical trial. A total of 198 participants with bronchial asthma are planned to be enrolled and … |
THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY | 2025-03-20 |
| 38 | A Randomized, Non-inferiority, Double-blind, Controlled, Single-dose, 2-way Cross-over Study to Assess The Potential for Airway Sensitivity Reactions With Propellants HFA-152a (Test) and HFA-134a (Reference) Administered Via Pressurized Metered Dose Inhalers in Adults Aged 18-45 With Mild Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess the propellants,1 – Difluoroethane \[HFA-152a\] (Test) and 1,1,1,2-Tetrafluoroethane \[HFA-134a\] (Reference) for their potential to cause the airways to tighten when delivered through pressurized metered dose inhalers (pMDI). The rationale for this study is to develop a low carbon footprint alternative propellant, HFA-152a, which will have a lower impact on global warming. |
ROBERT G BASS; | 2025-03-18 |
| 39 | Efficacy and Safety of Thread Embedding Acupuncture for Rhinitis Allergy: Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rhinitis allergy is chronic non-communicable disease with a rapid increase in the number of patients since 1990s. Rhinitis allergy is one of the risk factors for various chronic others including asthma, sinusitis, otitis media, as well as some conditions sleep disorders, emotional disorders related. There are numerous pharmacological and non-pharmacological therapies that have been employed in management of these condition. Among them, thread embedding acupuncture (TEA) has been a widely used and established method for various chronic diseases, demonstrating its effectiveness, safety, … |
BUI PHAM MINH MAN; | 2025-03-15 |
| 40 | Technology-Enhanced Asthma Care in Children at Clinic and Home (TEACCCH) Study (Aim 2): A Feasibility Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized controlled trial with parent-child pairs of children with persistent or uncontrolled asthma. An intervention group (n=40 parent-child pairs) will receive the mobile health (mHealth) app and digital sensors with enhanced support from a population health manager role, hereinafter referred to as an asthma coordinator, … |
KRISTIN KAN; | 2025-03-14 |
| 41 | The Effect of Mindfulness-Based Stress Reduction Programme on Stress, Anxiety, Self-Compassion and Prenatal Attachment in Pregnant Women with Perinatal Loss; A Randomised Controlled StudyMBSR PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research will be conducted to examine the effects of a mindfulness-based stress reduction (MBSR) programme on stress, anxiety, self-compassion and prenatal attachment in pregnant women with perinatal loss. This randomised controlled trial was conducted with 80 pregnant women with perinatal loss (40 participants in the experimental group and 40 participants in the control group). The experimental group will receive a total of eight sessions of MBSR in two sessions per week for four weeks. The data of the study will be collected by Personal Information Form, Tilburg Distress in Pregnancy Scale, Self-Compassion Scale Short Form, … |
HATICE GUL OZTAS; | 2025-03-10 |
| 42 | A Multicentre, Randomized, Double-Blind, Placebo Controlled, Dose Finding, Parallel Group, Phase 2 Study of An Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is trying to find the right dose of a long-lasting medicine called GSK5784283 for people with asthma that remains uncontrolled even though they are using regular asthma treatments. GSK5784283 blocks the action of an inflammatory protein called TSLP that may be contributing to your asthma. The study will be conducted in two parts – Part A (dose finding phase) and Part B (extended dosing phase). Part A will assess the lung function, asthma control, … |
DOMINIC TITONE; | 2025-03-04 |
| 43 | Local Antibiotic Delivery for Community Acquired Pneumonia – Pilot Study (LANDCAP1) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, double-blinded clinical pilot study to assess whether addition of inhaled levofloxacin 240 mg twice daily for three days leads to improved or worsened physiological status in CAP patients with and without pre-existing lung disease. |
COPENHAGEN RESPIRATORY RESEARCH | 2025-03-04 |
| 44 | A Multicenter Observational Study on The Current Status of Control and Treatment of Outpatient Children with Asthma and The Types of Airway Inflammation PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to comprehensively understand the disease control and management status of children with asthma in China, as well as the types of airway inflammation. The findings of this survey will help improve the asthma control level in Chinese children, facilitate future patient education, and guide rational medication use. Moreover, it will provide important evidence for health decision-making departments to better allocate and utilize medical resources. |
KUNLING SHEN; | 2025-03-01 |
| 45 | Study on The Efficacy and Mechanism of Acupuncture in The Acute Stage of Chronic Airway Diseases (Asthma and Chronic Obstructive Pulmonary Disease) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: For patients in the acute phase of chronic airway diseases, on the basis of guideline-directed treatment, the experimental group was given acupuncture treatment, while the control group was given sham acupuncture treatment. The treatment lasted for one week, followed by a 13-week follow-up. For asthma and COPD, PEF and CAT were respectively used as the primary outcome measures to evaluate the clinical efficacy and safety of acupuncture. Based on the improvement of the primary outcome measures, the advantageous population was identified. The mechanism by which acupuncture reduces airway mucus hypersecretion was preliminarily explained. |
HENAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE | 2025-03-01 |
| 46 | The Importance of Tailored Education And Device Handling for Asthmatic Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Significant advancements have been made in asthma medication over the past decades. Highly effective treatments are available for patients; however, both adherence and proper device usage remain below the desired levels, based on our experience and literature data. Despite the availability of numerous excellent drug-device combinations, personalized treatment for patients is still not adequately addressed. In the present study, the aim is to improve patient compliance and educate symptomatic, partially, or uncontrolled asthma patients on the correct use of a specific inhalation device (Nexthaler). Considering the characteristics of the medication, the patient’s lung function data, inhalation technique, … |
ILDIKÓ HORVÁTH; | 2025-03-01 |
| 47 | Automated Inhaler Monitoring for Asthma Medication Usage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the aflo™ digital platform’s ability to improve asthma control and inhaler technique for children, adolescents, and adults with uncontrolled asthma. The main questions the trial aims to answer are: 1. Does the aflo™ platform improve asthma control, as measured by changes in the Asthma Control Test (ACT) and lung function tests (FEV1, PEF)? 2. Does the platform improve medication adherence and inhaler technique, … |
WANDA PHIPATANAKUL; | 2025-03-01 |
| 48 | Comparison Of Upper Extremity Exercise Capacity Of Breast Cancer Patients With Healthy Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Breast cancer is one of the most common cancers among women worldwide, with an incidence rate of up to 16%. Although survival can be improved with early diagnosis and more effective therapies, physical complications such as lymphedema, upper extremity dysfunction and chronic pain are common during and/or after breast cancer treatments. In addition, lymphedema can cause symptoms such as decreased muscle strength and range of motion of the upper extremity, pain and fatigue, resulting in activity limitations and decreased functional level of the upper extremity. |
EBRU CALIK KUTUKCU; | 2025-03-01 |
| 49 | Can The Quality of Life of Adolescents with Asthma Be Improved By Focusing on Improving Their Asthma Self-management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND: Asthma is a long-term lung condition affecting 1 in 11 children and young people in the UK. Many teenagers have well controlled asthma, but a significant number continue to experience regular symptoms and asthma attacks leading to hospitalisations. While non-adherence to medication is a factor, teenagers also face challenges like changing relationships with parents and peers, avoiding triggers like smoking, and fitting in treatment with daily life demands. Healthcare professionals (HCPs) also face difficulties in managing teenagers with asthma. A previous study, funded by Asthma + Lung UK, … |
UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST | 2025-03-01 |
| 50 | A Single-centre, Single-dose, Open Label, Non-randomized, Parallel Group, Clinical Pharmacology Study of CHF 6001 in Asthmatic Adolescent Patients and in Asthmatic Adult Patients As Control Group PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the amount of the study drug, CHF6001, in the blood of adolescent patients with asthma in comparison to adult patients with asthma after a single oral dose of the study drug, CHF 6001. |
IVA POPOVA; | 2025-03-01 |
| 51 | A Phase Ib, Multicentre, Randomised, Single-blind, Parallel-group, Placebo-controlled, Study to Characterise The Pharmacokinetics and Pharmacodynamics of AZD4604 Administered Via The Turbuhaler® Device in Adults With Mild Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will investigate the Pharmacokinetic (PK), Pharmacodynamic (PD), the safety and tolerability of AZD4604, as well as to examine the effect of Fractional exhaled Nitric Oxide (FeNO) following the administration of the multiple doses of AZD4604 via Turbuhaler device. |
ASTRAZENECA | 2025-02-27 |
| 52 | Estudio Piloto Para La Aplicación De Dispositivos Bioelectrónicos Externos De Baja Potencia En El Diagnóstico De Asma Bronquial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to detect the acoustic signals generated by the respiratory system on asthma patients using an acoustic sensor and retrospectively use these signals to identify the characteristics that differentiate patients with asthma and healthy subjects. |
ACURABLE | 2025-02-27 |
| 53 | Pilot Study of Wearable Electronic Breath Sound Sensing Device for Monitoring of Breath Sounds in Pediatric Patients with Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the ability of a wearable stethoscope to monitor wheezing in high-risk asthma patients admitted at Children’s Healthcare of Atlanta. This study is important to assist in the health management of patients with chronic lung diseases that can experience exacerbations leading to their health worsening and requiring hospitalization. The population that will be approached for this study will include 10 pediatric subjects hospitalized at Children’s Healthcare of Atlanta for an asthma-related exacerbation. Participants will wear the patches for up to 8 hours on their chest and back wall from their date of consent until their hospital discharge. This may range from the participant taking part in 1 to 14 visits that could last up to 8 hours. |
LOKESH GUGLANI; | 2025-02-26 |
| 54 | The Effect of A Video- and Brochure-Based Physiotherapy and Exercise Program on Migraine Symptoms, Neck Disability, Cognitive Functions, and Quality of Life in Patients with Migraine: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effects of a video- and brochure-based physiotherapy and exercise program on migraine symptoms, neck disability, cognitive functions, and quality of life in patients with migraine. Hypotheses H1: The video-based physiotherapy and exercise program has an effect on migraine symptoms in patients with migraine. H2: The video-based physiotherapy and exercise program has an effect on neck disability in patients with migraine. H3: The video-based physiotherapy and exercise program has an effect on cognitive functions in patients with migraine. H4: The video-based physiotherapy and exercise program has an effect on quality of life in patients with migraine. H5: The brochure-based physiotherapy and exercise program has an effect on migraine symptoms in patients with migraine. H6: The brochure-based physiotherapy and exercise program has an effect on neck disability in patients with migraine. H7: The brochure-based physiotherapy and exercise program has an effect on cognitive functions in patients with migraine. H8: The brochure-based physiotherapy and exercise program has an effect on quality of life in patients with migraine. Participants diagnosed with migraine who meet the inclusion criteria and voluntarily agree to participate in the study will be randomly assigned to three groups using block randomization. The study will be conducted online. Before the intervention, participants will be asked to complete the Demographic Information Form, Migraine Disability Assessment (MIDAS) Questionnaire, Mig-Scog Questionnaire, Neck Disability Index (NDI), and SF-12 Quality of Life Questionnaire via an online Google Form. Group 1 will receive a video-based physiotherapy and exercise program. Group 2 will receive a brochure-based physiotherapy and exercise program. Group 3 will serve as the control group. Participants in the intervention groups will be instructed to perform the exercises three times per week for 12 weeks, with one session per day, consisting of 10 repetitions for each exercise. At the end of the 12th week, all assessments will be repeated to evaluate the effects of the intervention. |
GULHAN YILMAZ GOKMEN; | 2025-02-20 |
| 55 | DOSE Trial: Optimal Dose of Oral Corticosteroids to Treat Asthma Exacerbations: A Parallel, Randomized Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with severe asthma frequently experience exacerbations of their disease. The heterogeneity of asthma exacerbations represents a major challenge for patients and healthcare providers, making treatment difficult. Current guidelines recommend varying doses of short-term oral corticosteroids (OCS) as first-line treatment for asthma exacerbations. However, studies supporting the optimal dose of OCS to treat asthma exacerbations are rare. This study aims to evaluate the feasibility, acceptability, and safety of a randomized clinical trial with different OCS regimens for patients and physicians. Additionally, evaluate the success rate of different OCS dosages to support power calculations for a non-inferiority trial. In this pilot, … |
ANDRÉANNE CÔTÉ; | 2025-02-17 |
| 56 | A Randomized, Double-blind, Placebo-controlled, Parallel-group, 52-week Phase 3 Trial to Investigate The Efficacy, Safety, and Tolerability of Itepekimab in Adult Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: EFC18418 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study with 3 treatment groups. The purpose of the study is to evaluate the efficacy, safety and tolerability of 2 dosing regimens of itepekimab compared to placebo as add-on therapy to intranasal corticosteroids (INCS) in male and female participants with chronic rhinosinusitis with nasal polyps (CRSwNP) aged 18 years of age and older. Study details include: * The study duration per participant (4-week screening, 52-week treatment, 20-week safety follow-up) will be up to 76 weeks. For participants transitioning to the LTS18420 study, … |
SANOFI | 2025-02-12 |
| 57 | A Pilot Phase 2 Study of The Safety and Efficacy of Dupilumab As Add-on Therapy for Hypereosinophilic Syndrome With Partial Clinical Response to Eosinophil-Depleting Biologic Agents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Hypereosinophilic syndrome (HES) is a blood disorder that causes high levels of white blood cells called eosinophils. HES can damage the lungs and airways, intestines, skin, and other organs. The current primary treatment for HES can cause serious side effects. Secondary treatments do not work in all people. Objective: To test an approved drug (dupilumab), combined with other drugs, in people with HES. Eligibility: People aged 18 years and older who take drugs (mepolizumab, reslizumab, … |
AMY D KLION; | 2025-02-12 |
| 58 | Pai.ACT: An Artificial Intelligence-Driven Chatbot-Assisted ACT Mobile Platform With Mental Health Triage – A Randomized Controlled Trial and Regional Service Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Parents of children with special needs in Hong Kong often face limited psychological support, which can negatively impact the child rehabilitation process and the well-being of parent-child relationships. To address this gap, we have developed Pai.ACT, the first deep learning-based mental health advisory system for parents. Pai.ACT features an AI chatbot that integrates the counselling principles of Acceptance and Commitment Therapy (ACT) through natural language processing, providing parents with a human-like voice-to-text experience. Using data from chatbot interactions, … |
YUEN YU CHONG; | 2025-02-10 |
| 59 | A Phase II, Randomized, Double-blind, Single-dose, Placebo-controlled, 3-Period, 3-Treatment, Crossover, Multicenter Study to Compare The Bronchodilatory Effect and Safety of PT007 to Placebo MDI and Open-Label Ventolin® Evohaler in Adult Participants With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase II study, to investigate the therapeutic efficacy and safety of inhaled PT007 (referred to as AS MDI) compared with placebo MDI and open-label Ventolin Evohaler in male and female participants aged 18 to 65 years (inclusive) with asthma. This study consists of a screening/run-in period, a treatment period, and a follow-up phone call. |
ASTRAZENECA | 2025-02-10 |
| 60 | A Randomized, Double-blind, Placebo-controlled, Parallel-group, 52-week Phase 3 Trial to Investigate The Efficacy, Safety, and Tolerability of Itepekimab in Adult Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: EFC18419 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study with 3 treatment groups. The purpose of the study is to evaluate the efficacy, safety and tolerability of 2 dosing regimens of itepekimab compared to placebo as add-on therapy to intranasal corticosteroids (INCS) in male and female participants with chronic rhinosinusitis with nasal polyps (CRSwNP) aged 18 years of age and older. Study details include: * The study duration per participant (4-week screening, 52-week treatment, 20-week safety follow-up) will be up to 76 weeks. For participants transitioning to the LTS18420 study, … |
SANOFI | 2025-02-06 |
| 61 | Effects of Diaphragmatic Breathing and Relaxation Exercises in Patients with Gastroesophageal Reflux PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to examine the effects of diaphragmatic breathing exercises combined with relaxation exercises on patient-reported reflux symptoms, quality of life, anxiety, and depression levels in patients diagnosed with gastroesophageal reflux. |
TARIK OZMEN; | 2025-02-03 |
| 62 | Chronic Airway Disease and Miltimorbidity （CAM） Cohort: Protocol of A Prospective Multicenter Observational Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis, are highly prevalent and cause serious disease burden. Multimorbidity is recognized to influence treatment decision and prognosis of patients with stable CAD. The impact of multimorbidity on exacerbation CAD is under investigated. Methods: The Chronic Airway Disease and Miltimorbidity (CAM) cohort study is a prospective, multicenter, observational study aiming to recruit a minimum of 2000 patients hospitalized for exacerbation of COPD, asthma or bronchiectasis. Comprehensive data, including demographics, medical history, comorbidities, lung function, echocardiography, microbiological profiles, radiology, … |
TING YANG; | 2025-02-01 |
| 63 | A Prospective Non-interventional Real-world Study Assessing The Effectiveness of Extrafine BDP/FF/G (beclometasone Dipropionate/formoterol Fumarate/glycopyrronium) 172/5/9 Mcg, (pressurised Inhalation, Solution) Single Inhaler Triple Therapy (SITT) on Symptom Scores in Asthma Patients After 6 Months Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The mainstay of asthma treatment are ICSs, mostly and usually combined with LABA. In the past decade LAMA had been accepted as an add-on treatment for patients on GINA treatment Steps 4 and 5. Recently, RCTs proved the efficacy and safety of fixed triple combinations of moderate and high dose of ICS and LABA, LAMA in a very selected asthmatic population, resulting in the market authorization of these products. However, there is a lack of evidence on the real-world effectiveness of these therapies, especially with regards to improvement in symptom scores and quality of life. |
CHIESI BULGARIA | 2025-02-01 |
| 64 | A Study on The Changes and Prognosis of Intestinal Microbiota and Function in Infants With Food Allergies PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Microorganisms maintain a complex interrelationship with the human body, influencing each other. In recent years, people have gradually realized that the formation of the pediatric microecosystem is closely related to the development of gastrointestinal and even systemic immunity in children. The establishment of the pediatric microecosystem during childhood has significant implications for various diseases in adulthood. They are crucial for the host’s nutrition, metabolism, resistance to pathogens, and immune function. Increasing evidence supports the association between gut microbiota abnormalities and the pathophysiology of food allergies, … |
RUIJIN HOSPITAL | 2025-02-01 |
| 65 | Comparison of Conventional and Manometry Measurement Methods in The Evaluation of Perioperative Laryngeal Edema By USG in Patients Undergoing Lumbar Stabilization Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators aimed to evaluate perioperative laryngeal edema in patients undergoing lumbar stabilization surgery in the pron position, which the investigators use in our routine anesthesia practice, by using conventional and manometry measurement methods and ultrasonography, which the investigators also use frequently in our routine, and to evaluate complications related to laryngeal edema in postoperative service follow-up. |
MUSTAFA BERKEHAN NIZAMLIOĞLU; | 2025-02-01 |
| 66 | A Cohort Study on Biomarkers to Predict The Efficacy of Biologics for Chronic Rhinosinusitis with Nasal Polyps PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Recently, several biologic therapies have become available for treating chronic rhinosinusitis with nasal polyps (CRSwNP). However, not every patient responds to these treatments. This clinical trial aims to develop a non-invasive predictive model to help determine how effective IL-4Rα targeted monoclonal antibody therapy will be for individuals with CRSwNP. |
BEIJING TONGREN HOSPITAL | 2025-02-01 |
| 67 | Randomised Controlled Trial on An Early Warning System for Allergic Rhinitis in The MASK-air® App PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective consists in the comparison of the combined symptom medication score values between (i) patients randomised to the early warning system personalised forecasting messages, and (ii) patients randomised to generic messages already delivered by MASK-air®. The combined symptom medication score has recently been developed in a data-driven way and validated (https://eaaci.org/images/CSMS.pdf); it assesses allergic rhinitis control taking into account both reported symptoms and medication use. As secondary objectives, visual analogue scales on allergic rhinitis symptoms (VAS global, nasal, eye, asthma), and medication use will also be separately compared. |
UNIVERSIDADE DO PORTO | 2025-01-30 |
| 68 | A Study to Assess The Safety, Pharmacokinetics, and Pharmacodynamics of AZD8630, Administered Once Daily Via Inhalation, for 2 Weeks, in Adults With Asthma on Medium-to-high Dose Inhaled Corticosteroids and Long-acting Beta-agonists PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomised, placebo-controlled, double-blinded, sponsor-unblinded study to assess the safety, pharmacokinetic (PK), and pharmacodynamic (PD) effect of AZD8630 in adult participants with asthma on medium-to-high dose inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA). |
ASTRAZENECA | 2025-01-28 |
| 69 | Validity and Reliability of The Six-minute Peg Board and Ring Test in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to evaluate the validity and reliability of 6-PBRT in patients with rheumatoid arthritis and to determine the applicability of the test for this population. |
BAŞAK KAVALCI KOL; | 2025-01-26 |
| 70 | Pharmacokinetics, Pharmacodynamics, Safety, and Preliminary Efficacy of Subcutaneous Injection of SHR-1905 in Adolescent Asthmatic Subjects – An Open-label, Single-dose Phase II Clinical Study Related Papers Related Patents Related Grants Related Experts View |
GUANGDONG HENGRUI PHARMACEUTICAL | 2025-01-23 |
| 71 | Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent. Also, SDB shows high comorbidities with multisystem diseases. Furthermore, compared to patients with pure SDB, those comorbid with SDB and other disorders like cardiometabolic dysfunction and cognitive impairment experience poorer quality of life, higher rate of disease progression and mortality, and a greater economic burden. Currently, … |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2025-01-15 |
| 72 | Intestinal Microbiota Transplant As A Strategy to Enhance The Resilience Capacity of The Elderly Aiming to Retain Muscular, Cognitive, and Metabolic Functions in A Stressful Environment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sarcopenia, characterized by the progressive loss of muscle mass and strength in older adults, is a key factor in health deterioration. It affects 15% of people between 65 and 80 years old and over 50% of those over 80, compromising autonomy and increasing the risk of diseases. Sarcopenia not only impacts muscle function but also bone health, mobility, and is associated with cardiometabolic diseases and cognitive decline. It has been proposed that changes in the gut microbiota in aging individuals, known as gut dysbiosis, contribute to sarcopenia. Species diversity decreases, and bacterial representation is altered, … |
GONZALO JORQUERA; | 2025-01-10 |
| 73 | Effects of General Health Risk Factors on Prolonged Hospital Stay in Non-operating Room Anesthesia Preoperative Anesthesia Examination; Prospective Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: According to the literature, a detailed preoperative anesthesia assessment systematically verifies perioperative risks, provides functional and physiological optimization, improves the patient’s condition and the perioperative process, and prevents complications. In this context, the investigators aimed to determine the frequency of lifestyle risk factors in patients who applied to our clinic for preoperative anesthesia assessment due to adult gastrointestinal endoscopy, to investigate the relationship between lifestyle risk factors and factors and outcomes during the anesthesia procedure, and to compare the effects of these risk factors on developing complications and hospital stay. |
NAIME YALÇIN; | 2025-01-02 |
| 74 | Validation of The Kinshasa Lung Ultrasound Approach for The Narrowing of Differential Diagnosis in Children Admitted With Acute Respiratory Symptoms in Low-resource Settings PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study team will perform a prospective, observational study in two sites in the Democratic Republic of Congo (DRC) and Bangladesh in children aged 3 months to 14 years, admitted to hospital with acute respiratory symptoms. The Kinshasa lung ultrasound (K-LUS) approach integrates existing WHO clinical guidelines, lung ultrasound diagnostic accuracy evidence and paediatric ultrasound guidelines. The approach was built using a modified Delphi technique and integrates six LUS profiles, two clinical history features (timing of onset, trauma) and one clinical examination feature (fever) to suggest one among 10 clinical diagnosis. After the initial diagnosis is established by the treating physician, … |
LUIGI PISANI; | 2025-01-01 |
| 75 | Evaluation of Grass Pollen Sensitization Among Professionals Exposed or Not Exposed to Flour PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Occupational asthma are a major etiology of allergic asthma, especially among manual labor. The baker job exposes to significant level of flour. Some of allergenic components at work have simitudes with environmental allergens, for example cereals flour with gramineous pollens. GRAMIPRO is a retrospective cohort study that analyzes data from one specialized center at Créteil in the Paris region. The primary goal is to assess Participants include women and men aged over 18 years old at the time of their first consultation in the Occupational and Environmental Pathology Department of Créteil between April 2011 and July 2023, … |
CENTRE HOSPITALIER INTERCOMMUNAL CRETEIL | 2025-01-01 |
| 76 | A Retrospective Survey of The Time Course and Nature of The Experience of Initiating Biologic Treatment for People with Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe asthma is a disease characterised by respiratory and non-respiratory symptoms. The respiratory symptoms can include breathlessness, wheeze and asthma attacks. The disease can come to dominate patients’ lives, impacting their social, working and personal lives, leading to depression, anxiety and feelings of social isolation. There are now 7 different biologic treatments available on the NHS in the UK for severe asthma. These treatments have dramatically changed how severe asthma can be treated. Research has typically focused on the benefits of these drugs from a clinical perspective, e.g., improvements in lung function, … |
MATTHEW MASOLI; | 2025-01-01 |
| 77 | Fish Oil in PREgnancY for Personalized Prevention of Early Childhood Asthma (FREYA) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aim of the study is to develop a nutritional preventive fish oil supplementation strategy in pregnancy for early childhood asthma/persistent wheeze during the first three years of life as we hypothesize that both supplementations in higher doses than recommended could reduce the risk of disease development. |
KLAUS BØNNELYKKE; | 2024-12-20 |
| 78 | VItamin D in PregnanCy for PrevenTion of EaRlY Childhood Asthma (VICTORY) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma/persistent wheeze during the first three years of life as we hypothesize that supplementation in higher doses than recommended could reduce the risk of disease development. |
KLAUS BØNNELYKKE; | 2024-12-20 |
| 79 | A Randomized Controlled Study to Evaluate The Effect of Papworth Technique and Aerobic Training on Hemoglobin and Exercise Tolerance in Anemic Asthmatic Pediatrics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As asthma is chronic condition which interferes with quality of life and exercise tolerance, so it is important to find out cost-effective alternative for the management of asthma due to increased prevalence and rising health care cost as well . Therefore, to provide comprehensive asthma treatment, it is necessary to rule out and address the factor affecting quality of life and exercise tolerance. Asthmatics require stepwise approach which contains assessment treatment planning and review of response. Along with this modification of risk factors, … |
ALSHAIMAA ALSAYED ALI; | 2024-12-20 |
| 80 | The EVOLVE Study: A Prospective, Observational Study to Evaluate Patient-centered Outcomes Over 2 Years of Treatment With Tezepelumab in Real-life Clinical Practice in Greece PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tezepelumab is a first-in-class human monoclonal antibody for uncontrolled severe asthma that acts at the top of the inflammatory cascade by targeting thymic stromal lymphopoietin (TSLP), a key epithelial cytokine inducing both Type 2 and non- Type 2 inflammatory pathways. Considering the recent addition of tezepelumab to the severe asthma therapeutic arsenal, there is a need for real-world evidence that can inform treatment-decision making in clinical practice and support regulatory decisions. EVOLVE is a prospective, observational study designed to generate real-world evidence on patient-reported outcomes of treatment with tezepelumab, … |
ASTRAZENECA | 2024-12-17 |
| 81 | Remote Management Strategies and Adherence Improvement for Anxiety-related ICS Resistance in Asthma Patients: An Open-label, Multicenter, Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study, the Remote Anxiety Management for ICS-resistant Asthma Study (RAMICS), explores strategies to improve medication adherence and anxiety management in asthma patients who are resistant to using inhaled corticosteroids (ICS) due to anxiety. Asthma is a chronic respiratory disease affecting millions worldwide, and ICS therapy is essential for controlling symptoms and preventing severe exacerbations. However, many patients struggle with adherence, especially those with anxiety about ICS side effects. RAMICS is a multicenter, open-label, randomized controlled trial designed to evaluate the effectiveness of personalized telephone-based interventions, including medication education, progressive muscle relaxation (PMR), motivational interviewing (MI), … |
FIRST AFFILIATED HOSPITAL OF NINGBO UNIVERSITY | 2024-12-13 |
| 82 | A 4-Week, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Trial of Fluticasone Propionate/Albuterol Sulfate Combination Compared to Fluticasone Propionate, Albuterol Sulfate or Placebo Delivered By Multidose Dry Powder Inhaler in Participants 12 Years and Older With Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the trial is to evaluate the efficacy of fluticasone propionate/albuterol sulfate multidose dry powder inhaler with electronic module (Fp/ABS eMDPI). Secondary objectives are: * To evaluate the efficacy of Fp/ABS eMDPI administered four times daily * To evaluate the safety and tolerability of Fp/ABS eMDPI administered four times daily over four weeks * To investigate the pharmacokinetics of Fp/ABS eMDPI, ABS eMDPI and Fp eMDPI after administration of a single dose The planned study duration for each participant is approximately 10 weeks, excluding an optional prescreening visit. |
TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D | 2024-12-12 |
| 83 | Investigation of The Validity and Reliability of 6-minute Pegboard and Ring Test in Patients With Interstitial Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Interstitial lung diseases (ILD) are a heterogeneous group of chronic respiratory diseases that cause significant mortality and morbidity worldwide, characterized by diffuse inflammation in the lung parenchyma and vascular structures, can progress to fibrosis, have known or unknown etiology, and can develop secondary to systemic autoimmune connective tissue diseases other than diseases where the primary pathology is in the lung. The 6-minute peg-board and ring test, which was first developed to determine the upper extremity exercise capacity of chronic obstructive pulmonary disease patients, … |
MERAL BOŞNAK GÜÇLÜ; | 2024-12-12 |
| 84 | Intervention Effects of High-intensity Tai Chi in Mild or Moderate Asthma: A Preliminary Feasibility and Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1、 Research objective The main objective of this study is to investigate the therapeutic effect of a comprehensive lifestyle adjustment and stress management plan based on high-intensity Tai Chi on asthma patients. The main research areas are as follows: 1) Differences in therapeutic efficacy for mild or moderate asthma patients 2) Potential therapeutic efficacy for adult populations with different weight conditions. 2、 Research significance 2.1 Theoretical significance At present, … |
YUFEN WU; | 2024-12-10 |
| 85 | A Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate The Safety and Efficacy of Briquilimab in Participants with Allergic Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study JSP-CP-012 is designed as a proof of concept, parallel-group, single dose, double blind, placebo-controlled study using an allergen challenge model. A single dose proof of concept approach at a dose level shown to be biologically active should inform the impact of briquilimab on allergic asthma as compared to placebo while minimizing exposure to participants, in a new indication. |
JASPER THERAPEUTICS | 2024-11-26 |
| 86 | An Exploration of The Experiences and Support Needs of Young Adults With Severe and Uncontrolled Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a serious long-term lung condition caused by swollen airways that narrow. This causes wheezing, chest tightness, and breathlessness. Most asthma is well-controlled with medication. However, 5-10% of asthmatics have severe asthma where treatment does not control symptoms and up to 67% of asthmatics have uncontrolled asthma, caused by not always taking medication as recommended, lifestyle choices or other health problems worsening their asthma. In the UK, asthma affects around 800,000 young adults. This group is at high-risk of having poor asthma control, … |
LEANNE J HOLMES; | 2024-11-25 |
| 87 | Effect of Ultrasound-assisted Lung Recruitment Maneuver on Preventing Perioperative Atelectasis, Prospective Randomized Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is based on the hypothesis that recruitment maneuver reduces perioperative atelectasis and associated complications, and lung ultrasonography can be used to detect this. Patients aged 1 to 14 years with an ASA physical status classification of 1 to 3 and undergoing surgical procedures with a minimum duration of 2 hours will be included in the study. Patients with an ASA physical status classification of 4, including those with defined pulmonary diseases (e.g., asthma requiring medication and having had two emergency visits in the past year), prematurity ( <36 weeks gestation / bronchopulmonary dysplasia), cystic fibrosis, diagnosed syndromic conditions, ... |
ŞEYMA KARADUMAN BULUT; | 2024-11-25 |
| 88 | An Observational, Prospective, Multicenter Study to Evaluate The Biologic Use and Outcomes in Chinese Asthma Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter, observational, prospective study to evaluate the asthma biologic use features and clinical outcomes in China. Patients will undergo clinical assessments and receive standard medical care as determined by the treating physician. |
YUBIAO GUO; | 2024-11-14 |
| 89 | A Prospective, Multicenter, Self-controlled Clinical Trial to Validate Optical Ultrasonic Flow Ratio (OUFR) Based on Intravascular Imaging PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of is study is to validate a novel computational Fractional Flow Reserve (FFR) index method, termed Optical Ultrasonic Flow Ratio (OUFR), based on intravascular imaging including intravascular optical coherence tomography (OCT) and intravascular ultrasound (IVUS), using wire-based FFR as the gold standard. This is a prospective, multi-center, self-controlled clinical trial involving at least four medical centers and recruiting at least 114 subjects based on statistical power analysis. Participants undoing anticipated percutaneous coronary intervention will be performed: 1. Wire-based FFR measurement 2. Intravascular imaging, … |
YU BO; | 2024-11-10 |
| 90 | A Randomized, Phase 2, Double-blind, Placebo-controlled, Parallel-group, 2-arm Study to Investigate The Efficacy, Safety, and Tolerability of Subcutaneous Lunsekimig (SAR443765) in Adult Participants With High-risk Asthma Who Are Not Currently Eligible for Biologic Treatment PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a parallel-group, Phase 2, randomized, double-blind, placebo-controlled, 2-arm study for the treatment of asthma. The purpose of this study is to assess the efficacy, safety, and tolerability of add-on therapy with SC lunsekimig compared with placebo in male and female participants (aged 18 to 80 years, inclusive) with asthma, … |
SANOFI | 2024-11-07 |
| 91 | AeviceMD for Pediatric Asthma Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A wearable remote patient monitor (AeviceMD) is to be used to monitor the respiratory health of pediatric asthma patients in this pilot study. Patients prescribed with AeviceMD should be able to gain better control over their disease during home management. Physicians should be able to optimize treatment for these patients using objective data collected from and of these patients outside of the clinic. The AeviceMD should also be used as a remote auscultation device for teleconsultations. |
IRINA DRALYUK; | 2024-11-05 |
| 92 | A Single Centre Randomised, Feasibility Study Using Point-of-care (POC) Testing for Respiratory Viruses to Direct Oral Corticosteroids Use in Preschool-aged Children with Acute Wheeze PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Young children frequently attend the emergency department (ED) with wheeze which is usually triggered by a virus infection, such as the common cold. Wheeze can be treated with inhaled medications and sometimes oral steroid medicines are also given to reduce swelling within the lungs. Unfortunately, … |
THOMAS WATERFIELD; | 2024-11-04 |
| 93 | Pilot Sequential Multiple Assignment Randomized Trial for RSV Vaccine Uptake in Pregnancy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Central hypothesis: a multimodal approach is needed to enhance RSV vaccine uptake in pregnancy rather than the current standard of care that relies solely on physician recommendations at routine prenatal visits and/or mass messaging to the public. The investigators propose a pilot sequential multiple assignment randomized trial (SMART) to evaluate the effectiveness of a bundle of evidence-based and sequential strategies to test early (28-30 weeks gestation) and late (34-36 weeks gestation efficacy) to increase RSV vaccination during pregnancy. |
JEANNIE KELLY; | 2024-11-04 |
| 94 | Expanding Pulmonary Rehabilitation in Other Chronic Respiratory Disease Than COPD – The ExPuRe Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pilot randomized clinical trial is to evaluate the willingness, acceptance, adherence and signs of benefits of structured home-based pulmonary rehabilitation (HPR) and supervised pulmonary tele-rehabilitation (PTR) on respiratory symptoms, quality of life, functioning and physical activity in patients with ILD (Interstitial lung disease, Idiopathic pulmonary fibrosis, Sarcoidosis), … |
HENRIK HANSEN; | 2024-11-01 |
| 95 | Comparison of Physiological Responses of Virtual Reality Walking Exercise Compared to Walking Performed on Treadmills in Healthy Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to systematically compare the physiological responses generated by walking exercises conducted in a VR environment versus those performed on a treadmill, with a specific focus on their impacts on the autonomic nervous system and fatigue levels |
ATLAS UNIVERSITY | 2024-11-01 |
| 96 | Risk Factors Affecting Chronic Postoperative Pain After Elective Nephrectomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic postoperative pain (CPP) is typically defined as pain persisting for 3 months or more after surgery[1]. CPP is a common and increasingly prevalent morbidity, leading to long-term psychological issues, reduced quality of life, and impaired functionality[2]. To reduce the incidence of CPP, high-risk patients are identified, and various surgical techniques, pharmacological agents, and regional anesthesia techniques are employed[3]. The primary aim of our study is to scale chronic pain at 1 hour, 3 months, and 1 year post-nephrectomy using the Numeric Rating Scale (NRS), … |
İLAYDA BILGILI ALTUNTAŞ; | 2024-10-31 |
| 97 | Establishment of A FeNO Cutoff Value for Evaluating The Response to Budesonide-formoterol in Patients With Chronic Cough Suggestive of Cough Variant Asthma: A Multicenter Prospective Clinical Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, prospective, single-arm, interventional clinical study to predict the response to budesonide-formoterol treatment in patients with chronic dry or nocturnal cough by determining a cut off value of FeNO. In this study, the response to ICS/LABA treatment is defined as reduction in cough VAS score from baseline of ≥30 mm after 8 weeks of ICS/LABA treatment. Subjects will be treated with Symbicort® 160/4.5 mcg, 1 puff, BID for 8 weeks with 4 study visits: Visit 1 (Day 0), Visit 2 (week 4) and Visit 3, end of study (week 8) and Visit 4, … |
KEFANG LAI; | 2024-10-25 |
| 98 | Bidirectional Mendelian Randomization Study Reveals Causal Associations Between Allergic Rhinitis and Asthma PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the causal relationship between allergic rhinitis and asthma using a bidirectional two-sample Mendelian randomization approach. Genetic data were derived from UK Biobank for allergic rhinitis and from Finnish biobank for asthma. This analysis aims to clarify the potential causal link between these two conditions. |
ZHIBIN XU; | 2024-10-01 |
| 99 | Evaluation of The Digital Delivery of Person-centered Transitional Care to Empower Adolescents With Chronic Childhood-onset Diseases: The Digi-STEPSTONES Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Advances in medical care have extended the life expectancy of individuals with congenital and pediatric-onset diseases, leading to an increased need for effective transition programs as these individuals move from pediatric to adult healthcare. The STEPSTONES project in Sweden is designed to evaluate the effectiveness of a person-centered transition program to support teenagers with chronic conditions during this transition. The project’s innovative digital adaptation, Digi-STEPSTONES, seeks to address challenges related to accessibility and continuity of care by delivering the program remotely. This study will assess the non-inferiority of the digital program compared to traditional, in-person care, … |
EWA-LENA BRATT; | 2024-10-01 |
| 100 | Effects of Short-Term Conscious Awareness-Based Cognitıve Therapy Applied to Asthma Patients on Anxiety, Depression and Dyspnea PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, short-term MBCT will be applied to asthmatic patients receiving hospital treatment and its effects on anxiety, depression and dyspnea will be determined. A quasi-experimental study was planned for this purpose. |
DERYA ŞİMŞEKLİ; | 2024-10-01 |
| 101 | The Increase of Lung Capacity Using The Lung Master (Pulmonary Exerciser) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators are studying how a device called The Lung Master device can help people breathe better. The investigational device increases the amount of air our lungs can hold, which is important for overall lung health. The Lung Master is not approved by the FDA. The study has two visits approximately one month apart. In the first visit participants will take a spirometry test, particularly forced vital capacity (FVC), to measure volume change in the lungs. Participants will take the investigational device home to use daily, … |
FARAHNAZ FALLAH TAFTI; | 2024-10-01 |
| 102 | An Open Label Extension Study to Evaluate The Long-term Safety and Efficacy of Subcutaneous Lunsekimig in Adult Participants With Moderatetosevere Asthma Who Participated in Study DRI16762 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2, open-label extension study to evaluate the long-term safety and efficacy of lunsekimig in adult participants with moderate-to-severe asthma who have previously completed the parent study. After completion of the parent study, eligible participants will be offered the opportunity to participate in the long-term extension (LTE) study with lunsekimig. The study duration will be up to 100 weeks with a treatment duration being up to 96 weeks. |
SANOFI | 2024-09-30 |
| 103 | A Multicentre, Randomised, Open-Label, Parallel-Group, Phase IIIb Study to Assess The Potential for Tezepelumab-treated Patients With Severe Asthma to Reduce Background Therapy While Sustaining Asthma Control and Clinical Remission PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to assess the potential for tezepelumab-treated patients (subcutaneous administration) to reduce maintenance therapy without loss of asthma control in adolescent and adults with severe asthma.. Study details include: 1. The study duration will be up to 72 weeks. 2. The treatment duration will be up to 68 weeks. 3. The visit frequency will be once every 4 weeks (Q4W). |
ASTRAZENECA | 2024-09-30 |
| 104 | Development of An Active Video-Based High-Intensity Interval Exercise System in Children with Asthma and Investigation of Immediate Responses PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to develop an active video-based high-intensity interval exercise system for the rehabilitation programs of children with asthma and to compare its immediate effects on heart rate variability, hemodynamic responses and thermal responses with a conventional high-intensity interval exercise. |
MELISSA KÖPRÜLÜOĞLU; | 2024-09-30 |
| 105 | Project ASTHMA – Aligning With Schools To Help Manage Asthma and Decrease Health Inequities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency department visits, and hospitalizations. Project ASTHMA (Aligning with Schools To Help Manage Asthma) tests the effectiveness of school-based health centers as a delivery model to improve health outcomes by providing children with guideline-based asthma assessments and preventive medication management, directly observed therapy of their preventive medication to support adherence, and self-management support. If successful, … |
LUCY HOLMES; | 2024-09-27 |
| 106 | Comparative Effects of Upper Extremity Proprioceptive Neuromuscular Facilitation and Chest Expansion Exercises on Thoracic Mobility in Children With Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Thoracic mobility is the mobility of the thoracic spine, and the rib cage is often measured by the degree of thorax expansion during breathing. Thoracic mobility is affected by many reasons, such as breathing mechanics, muscle stiffness, a sedentary lifestyle, … |
NAIMA KHALID; | 2024-09-26 |
| 107 | Soy Isoflavones for Inner City Infants At Risk for Asthma (SIRA) Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare soy isoflavones to placebo in children who at risk of asthma and have a genetic variation which results in them making more of a pro-inflammatory protein, plasminogen activator inhibitor-1. The main questions this trail seeks to answer is: will soy isoflavones decrease the proportion of infants with aT2 high endotype at the end of treatment, … |
RAJESH KUMAR; | 2024-09-18 |
| 108 | Utilization of Asthma Medication During Pregnancy: An Multinational, Cross-sectional, Internet-based Study – French Contribution PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In the last decades, the prevalence of asthma increased substantially and is still increasing in many countries. Approximately 8% of pregnant women have asthma, making it one of the most common chronic conditions during pregnancy. Systematic reviews showed that pregnant women with asthma have an increased risk of pregnancy complications and adverse birth outcomes. Hence international recommendations emphasize the importance of adequate pharmacological treatment, stating that poor asthma control is associated with higher risks for the unborn child compared with asthma medication use. Multiple studies using large population-based database, however, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2024-09-15 |
| 109 | The Diagnostic Significance of Exhaled Nitric Oxide (FeNO) With A Novel Technology in The Assessment of Bronchial Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The detection of exhaled nitric oxide (FeNO) represents a non-invasive, safe, and rapid approach for assessing endogenous nitric oxide (NO) levels within the airway. FeNO concentrations are closely associated with airway inflammation and hyperresponsiveness, and are currently recognized as biomarkers indicative of type II airway inflammation. Recent advancements in nitric oxide detection technology for both upper and lower airways, as well as for small and large airways, have provided significant insights for the diagnosis and management of conditions such as bronchial asthma, chronic cough, upper airway diseases, chronic obstructive pulmonary disease, and even rare airway disorders. Presently, … |
AILING SONG; | 2024-09-12 |
| 110 | A 12-week, Randomized, Double-Blind, Phase 4 Study Evaluating The Effect of AIRSUPRA Compared to Albuterol Administered As Needed on Changes in Airway Inflammation, Symptoms, and Rescue Therapy Utilization in Adults With Mild Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the efficacy and safety of albuterol/budesonide to albuterol in changes in airway inflammation, asthma symptoms, and rescue therapy utilization in adults with mild asthma. Study details include: * The study duration will be up to 15 weeks. * The treatment duration will be 12 weeks. * The visit frequency will be once every 4 weeks, with 3 clinic visits and 2 video calls in total. |
ASTRAZENECA | 2024-09-11 |
| 111 | Multicentre, Single Arm, Non-interventional, Observational, Prospective Study to Assess Demographic Characteristics, Burden of Disease and Short-term Patient Reported Outcomes on Symptom Relief in Severe Asthma Patients Aged Older Than 12 Qualifying for Treatment With Tezepelumab in Russia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ELBRUS is a 12-month (52-week), multi-centre, prospective, non-comparative and non-interventional (observational), post-reimbursement real-world evidence study that will assess patient-reported outcomes after tezepelumab treatment initiation in participants with severe asthma in Russia. |
ASTRAZENECA | 2024-09-10 |
| 112 | A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Assess The Efficacy of PURETHAL Mites Mixture 50,000 AUeq/mL Subcutaneous Immunotherapy in Adult Subjects With Moderate to Severe Allergic Rhinitis/Rhinoconjunctivitis With or Without Asthma Induced By House Dust Mite PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Allergic rhinitis/rhinoconjunctivitis (ARC) is a global health problem, affecting 10-25% of the population. Allergen-specific immunotherapy is the only disease-modifying therapeutic option for subjects with house dust mites (HDM)-induced allergic rhinitis/rhinoconjunctivitis. This Phase 3 clinical study aims to demonstrate the effecacy of PURETHAL Mites (PM) Mixture subcutaneous immunotherapy (SCIT) compared to a placebo over one year of treatment in patients with moderate to severe HDM- induced allergic rhinitis/rhinoconjunctivitis (ARC), while also prioritizing the safety of the treatment. PM Mixture is a suspension of chemically modified extract from the house dust mites Dermatophagoides pteronyssinus (D. pter) and Dermatophagoides farinae (D. far), … |
HAL ALLERGY | 2024-09-09 |
| 113 | Milk Temperature Control and Necrotizing Enterocolitis Risk in Extremely Preterm Infants: A Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Necrotizing enterocolitis (NEC) is one of the most common and severe gastrointestinal emergencies during the neonatal period, especially among preterm infants. In high-income countries such as Finland and the USA, the prevalence of NEC ranges from 2% to 16.58% among very preterm infants (VPIs) and from 6.8% to 10.0% among extremely preterm infants (EPIs). According to the 2022 Annual Report of the China Newborn Collaboration Network (CHNN) from 89 tertiary hospitals, the prevalence of NEC was reported at 14.2% among VPIs and EPIs. Up to half of NEC cases in infants require surgical intervention, … |
CHEN LONG; | 2024-09-01 |
| 114 | A Phase 2b, Randomised, Double-Blind, Placebo-Controlled Dose Range-Finding Study to Assess Efficacy and Safety of Multiple Dose Levels of Inhaled AZD8630 Given Once Daily for 12 Weeks in Adults With Uncontrolled Asthma at Risk of Exacerbations (LEVANTE) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A dose range-finding study to assess the efficacy and safety of multiple dose levels of AZD8630 administered via a dry powder inhaler in adults with uncontrolled asthma at risk of exacerbations, receiving medium -to -high dose inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA). |
NJIRA LUGOGO; | 2024-08-30 |
| 115 | AIM4: Next Step – Asthma Uncontrolled With ICS in Medium Dose (GINA 4): Next Step; Efficacy of Dupilumab Added to Medium Dose ICS/LABA in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Patients With Uncontrolled Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is researching a drug called dupilumab. The study is focused on patients who have uncontrolled asthma. Asthma is a condition where the airways narrow and swell, … |
REGENERON PHARMACEUTICALS | 2024-08-26 |
| 116 | Effects of Balloon-blowing Exercises in 90/90 Bridge Position With A Ball on Pulmonary Function Among Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In asthma, the airways in the respiratory system can experience inflammation and constriction, causing increased difficulty in expelling air during exhalation. This results in disruptions to respiratory parameters, exercise intolerance, and a diminished overall quality of life.Engaging in balloon-blowing exercises while in a 90/90 bridge position with the use of a ball will lead to enhanced pulmonary function and quality of life in individuals with asthma. |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-08-15 |
| 117 | A Pilot Randomized Controlled Trial: Utilizing A Digital Inhaler to Support Asthma Management in Adolescents With Intellectual and Developmental Disabilities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Correct use of daily medications containing inhaled corticosteroids is key for asthma control, yet children with intellectual and developmental disabilities (IDD) face additional barriers to proper inhaler use. Smart inhalers, a novel technology that provides guidance and immediate feedback on inhaler use techniques, have been shown to enhance correct medication administration in the typically developing pediatric population, but their effectiveness has not been evaluated on the pediatric IDD population. This study aims to investigate whether daily application of smart inhalers (1) is feasible and acceptable in the IDD population, (2) improves the rate of correct medication administration, … |
LARRY YIN; | 2024-08-13 |
| 118 | Methacholine Challenge Test (MCT) in Healthy Adults: Oscillometry Measured Alone Compared to Oscillometry and FEV1 During The Same Test PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knowledge of Methacholine Challenge Test (MCT) and impedance Oscillometry (IOS) is limited. Only three studies have included adult patients, and none of these with healthy controls. The three studies have combined IOS and spirometry in the same test, although it is not recommended to perform IOS after a test that requires deep breathing, e.g. FEV1 measurement. Deep breathing is considered to affect the impedance via reduced tone in the smooth muscle. |
THOMAS RINGBÆK; | 2024-08-10 |
| 119 | A Randomised, Double-blind, Parallel Group, Placebo Controlled, 4-Week, Phase II Study to Evaluate The Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the effect on airway inflammation and JAK1-associated signalling pathways of AZD4604 compared with placebo in participants with moderate-to-severe asthma. Study details include: * The study duration for each participant will be approximately 10 weeks. * The duration of IMP administration will be approximately 4 weeks. |
ASTRAZENECA | 2024-08-05 |
| 120 | The Effect of Anti-IL17 on Airway Hyperresponsiveness and Resistance: A Longitudinal Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational longitudinal cohort study aims to assess the effect of monoclonal antibodies targeting interleukin 17 (anti-IL-17) on airway hyperreactivity and airway resistance. The study involves adult participants suffering from dermatological or rheumatological illness, who are planning to start treatment with monoclonal antibodies targeting interleukin 17 as a part of the treatment of these diseases. The primary outcome of this study will be changes in airway hyperresponsiveness to methacholine challenge reported as response-dose-ratio before and after initiation of anti-IL17 treatment regardless of presence of respiratory disease. Furthermore, … |
JONAS BAEKDAL; | 2024-08-02 |
| 121 | Comparison of Symptoms, Respiratory Dysfunction and Frailty Level in Allergic and Eosonophilic Asthmatics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine the level of respiratory dysfunction, symptoms and frailty in patients with asthma according to different endophenotypes (allergic and eosonophilic asthma). In the light of the data obtained, it is thought that rehabilitation approaches that can be determined according to different endophenotypes in line with the evaluated parameters will guide health professionals working in this field. Hypotheses H0: There is no difference between allergic and eosonophilic asthmatics in terms of pulmonary function, respiratory dysfunction, symptoms, dyspnoea, fatigue, rhinitis, perception of breathlessness in activities of daily living, asthma control, … |
EBRU CALIK KUTUKCU; | 2024-08-01 |
| 122 | The Effect of Body Composition on Respiratory Parameters, Functional Capacity and Sleep in Healthy Young Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Body composition has a significant effect on the respiratory system. Both respiratory prediction of function and a prognostic tool evaluated in the cardiopulmonary system factor. Respiratory function, which directly affects respiratory muscle strength and respiratory muscle endurance covers a range of data. In the literature, the relationship between body composition and respiratory function. Although there are studies examining body composition in healthy young adults, the relationship between them has not been clearly demonstrated. The aim of the study was to investigate the effects of body composition on respiratory function, respiratory muscle endurance, functional capacity and sleep quality. For this purpose, … |
MELIS USUL; | 2024-08-01 |
| 123 | A Phase 2, Randomized, Double-blind, Placebo-controlled, Multiple Dose-Ranging Study to Assess The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Solrikitug in Adult Participants With Asthma (RAINIER) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase 2 study to evaluate the safety, tolerability, PK, immunogenicity, and pharmacodynamics of solriktug with adult participants with asthma. |
UNIQUITY ONE UNI | 2024-07-26 |
| 124 | A Non-interventional, Prospective Study With Benralizumab to Investigate Clinical Outcome Based on Standard of Care Medication in Real-life PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, non-interventional, single-arm, multicenter study to investigate asthma control, and health-related quality of life (HRQL), lung function and asthma medication intake in severe eosinophilic asthma patients treated with benralizumab in a real-life setting in Germany. |
ASTRAZENECA | 2024-07-25 |
| 125 | Effect of Education on Asthma Knowledge, Control and Quality of Life in School-Age Children Diagnosed With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the effects of asthma education on asthma knowledge, control and quality of life of school-aged children (7-11 years old) diagnosed with asthma and followed up in the outpatient clinic. |
ATIYE YILDIRIM; | 2024-07-25 |
| 126 | The Effects of Breathing Exercises and Postural Exercises Via Telerehabilitation on Respiratory Parameters, Posture, and Quality of Life in Young Adults With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to investigate the effects of breathing exercises and postural exercises via telerehabilitation on respiratory parameters, posture, and quality of life in young adults with asthma. |
ELIF DEVELI; | 2024-07-24 |
| 127 | A Randomized, Placebo-controlled, Double-blind, Multicenter, 12-Week, 3-Way, Partial-replicate Crossover Pharmacodynamic Study to Assess The Equivalence of Budesonide and Albuterol (BDA) Delivered By MDI HFO Compared With BDA Delivered By MDI HFA in Participants With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the PD equivalence of the approved asthma combination therapy, BDA, delivered using the proposed replacement propellant HFO compared with BDA delivered using the currently approved propellant HFA in participants with asthma. |
ASTRAZENECA | 2024-07-22 |
| 128 | A Randomized Phase 2, Double-blind, Placebo-controlled, Parallel-group, 2-arm Study to Assess The Efficacy, Safety, and Tolerability of Subcutaneous Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a parallel, Phase 2, 2-arm, multicenter, randomized, double-blind, placebo-controlled, proof-of-concept study for treatment of CRSwNP. The purpose of this study is to assess the efficacy, safety, and tolerability of add-on therapy with subcutaneous lunsekimig in adult participants (aged 18 to 70 years, inclusive) with CRSwNP who are inadequately controlled on intranasal corticosteroid treatment. Participants with and without co-morbid asthma will be included in the study, and lung function will be assessed in both groups. The study duration will be up to approximately 40 weeks per participant, including 4 weeks of screening run-in period, 24 weeks of intervention period, … |
SANOFI | 2024-07-17 |
| 129 | A Randomized, 52-Week Treatment Double-Blind, Placebo-Controlled Efficacy and Safety Study of Dupilumab 300 Mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on A Background Therapy With Intranasal Corticosteroid Spray Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Allergic fungal rhinosinusitis (AFRS) is a severe type of sinus infection. People with AFRS develop heavy mucus and growths called polyps that apply pressure to the sinuses and block their breathing. Surgery can remove the polyps, … |
JOSHUA LEVY; | 2024-07-17 |
| 130 | Characterisation of Skin Microstructure Under Normal and Atrophied States PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Skin dermatoses are a major health concern around the world, with heavy economic, social, and psychological burdens. Due to their chronic and incurable nature, they are serious diseases that cause physical pain in patients and reduced quality of life. Atopic dermatitis is the most common inflammatory skin disease with a prevalence of almost 20% in children and 10% in adults. Current therapies are designed to control the condition rather than cure it. Therefore, these therapies are lifelong and, when the disease is flaring, must be used intensively to achieve control. Despite the emergence of various therapies, … |
MICHAEL J CORK; | 2024-07-16 |
| 131 | FASENRA® Subcutaneous Injection 30 Mg / 10mg Syringe Protocol of Specific Drug Use Result Study for Pediatric Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the investigation is to confirm the followings under the post-marketing actual use of Fasenra® Subcutaneous Injection 30 mg / 10mg Syringe (hereinafter referred to as Fasenra). 1. Development of unexpected related AEs\* 2. To grasp development of related AEs\* in the real-world post-marketing setting. 3. Effectiveness (pulmonary function and asthma control) \* AEs investigator or MAH considers that there is a reasonable possibility that the experience may have been caused by the drug |
ASTRAZENECA | 2024-07-16 |
| 132 | Effects of An Educational Intervention Program on Lung Function and Ergonomic Hazards Among Marble Factory Workers: Quasi-experimental Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Marble cutting exposes workers to dust, increasing risk of lung diseases like asthma, COPD, silicosis, and asbestosis. Many marble cutters in rural areas lack awareness of these risks and work without proper protection. Khyber Pakhtunkhwa has over 4000 marble factories employing over a million laborers, mostly unskilled and vulnerable. Workers face health risks from heavy lifting, poor posture, and respirable dust. Ergonomic disorders are also common due to poorly designed workstations, repetitive motions, and straining postures. Musculoskeletal Symptoms (MSS) can progress into Musculoskeletal Disorders (MSDs), … |
SUMAN SHERAZ; | 2024-07-15 |
| 133 | The Relation Between Atopy and Frequency of Exacerbation in Chronic Obstructive Pulmonary Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production and/or exacerbations) due to abnormalities of airways (bronchitis, bronchiolitis) and/or alveoli (emphysema) that cause persistent, often progressive, airflow obstruction. The presence of non-fully reversible airflow obstruction (FEV1/FVC < 0.7 post-bronchodilation) measured by spirometry confirms the diagnosis of COPD |
MOHAMED ABD ELMONIEM MOHAMED; | 2024-07-14 |
| 134 | Mobile Apps for Preschool Parents (MAPP) Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of Mobile Apps for Preschool Parents (MAPP) Study is to test the effectiveness of two mobile applications for parents of preschool aged children: 1) an app focused on child and family nutrition and wellness, and 2) an app focused on parents reading to their children. |
PAMELA HULL; | 2024-07-01 |
| 135 | Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be conducted to identify factors predicting the response of chronic rhinosinusitis with nasal polyps ( CRSwNP) to oral corticosteroids. |
KATRINA ATEF HABASHY; | 2024-07-01 |
| 136 | Evaluation of The Effectiveness of A Technology-based Program Delivered By Peer-led and Adult Educators to Adolescents Diagnosed With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The research was planned in a randomized controlled trial to evaluate the effect of technology-based education provided by peers and adults to children diagnosed with asthma in the 12-18 age group. The study will be conducted in two phases. The initial phase will assess the efficacy of the training provided to peer mentors. The subsequent phase will examine the impact of peer-led and adult-delivered technology-based education on quality of life, asthma control, asthma knowledge, … |
EMINE GÜNEŞ ŞAN; | 2024-07-01 |
| 137 | Exploration and Study on The Identification of Various Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) marker molecules. This model aims to accurately diagnose mutiple pulmonary diseases. The primary objectives it strives to accomplish are: 1. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose several common pulmonary diseases. 2. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose more pulmonary diseases. |
CHROMX HEALTH | 2024-06-30 |
| 138 | An Ambispective Observational Multicenter Registry of Patients With Uncontrolled Asthma in The Population of The Russian Federation PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-centre, non-interventional, observational, ambispective registry. Planned study population consists of 10 000 adult patients with uncontrolled asthma receiving treatment according to standard of care (except biologics). Planned number of study site is 70 outpatient centers with experience of uncontrolled asthma treatment in about 50 regions of Russia (in order to describe characteristics of patients with uncontrolled asthma in different regions in the most comprehensive way). |
ASTRAZENECA | 2024-06-27 |
| 139 | The Effect of Video-Based Breathing Exercises Taught to COPD Patients on Dyspnea Severity, Activity Level, and Sleep Quality PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is one of the most prevalent and high-mortality chronic diseases worldwide. Symptoms such as dyspnea, cough, sleep disturbances, fatigue, restricted activity levels, anxiety, and depression develop in COPD patients, negatively affecting their quality of life. Dyspnea, associated with various symptoms in COPD patients such as reduced activity levels and sleep disturbances, is a significant issue. Therefore, effective management of dyspnea will contribute to reducing other important problems associated with COPD. One of the non-pharmacological methods used in managing these symptoms associated with COPD is breathing exercises. Particularly, … |
AYFER BAYINDIR ÇEVIK; | 2024-06-20 |
| 140 | Additive Effects of Alternative Nostril Breathing with Pharmacological Management on Dyspnea and Control Pause in Patients with Bronchial Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchial asthma is a widespread chronic condition charactrized by inflammation and narrowing of airways, leading to repeateted episodes of breathlessness, wheezing and labored breathing.Breathing exercises help to manage hyperventilation often seen in asthmatic patients. To handle respiratory complications asthmatics are advised to practise nasal breathing techniques in conjunction with their prescribed medications. |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-06-18 |
| 141 | A Randomized, Double-blind, Multicentre, Event-driven, Parallel Group, Phase III Study Evaluating The Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Symptomatic Chinese Adults With Asthma (BAIYUN) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: An event-driven, Phase III study to evaluate the efficacy and safety of BDA MDI compared with AS MDI in reducing the risk of a severe asthma exacerbation in symptomatic Chinese adults with asthma. |
ASTRAZENECA | 2024-06-17 |
| 142 | Assessing The Efficacy of Ginger Powder Capsules As An Analgesic for Intraoperative and Post- Endodontic Pain Management in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate the analgesic effect of ginger powder capsules compared to placebo on intra-operative and post-operative pain of single-visit endodontic treatment of mandibular molars with symptomatic irreversible pulpitis. |
OMAR ALDERBASHI; | 2024-06-15 |
| 143 | Safety, Tolerability and Pharmacodynamics of Single and Multiple Ascending Doses of OM-85-IN Versus Placebo in Healthy Volunteers, and Patients With Mild Allergic Asthma Using Nasal Allergen Challenge PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the safety and tolerability of OM-85-IN compared to placebo in healthy volunteers and mild asthmatic patients |
OM PHARMA SA | 2024-06-14 |
| 144 | An Open-Label Long-Term Phase III Extension Study to Assess The Long-Term Safety and Tolerability of Dexpramipexole in Participants With Severe Eosinophilic Asthma PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial\] is to evaluate the long term safety of dexpramipexole treatment in participants with severe asthma, aged ≥12 years, on Global Initiative for Asthma (GINA) 2021 \[GINA, 2021\] Step 4 or 5 therapy and who completed either of the Phase III studies EXHALE-2 or EXHALE-3. |
SADY ALPIZAR; | 2024-06-12 |
| 145 | An Observational Multicenter Cross-sectional Study of Patients With Uncontrolled Severe Asthma in The Population of The Russian Federation PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an observational multicenter cross-sectional study. Planned study population consists of 5 000 adult patients with uncontrolled SA receiving treatment according to standard of care (except biologics). Planned number of study site is 50 outpatient centers with experience of uncontrolled SA treatment in about 50 regions of Russia (in order to describe characteristics of patients with uncontrolled SA in different regions in the most comprehensive way). This non-interventional study does not imply any intervention into a routine clinical practice, and does not provide for any diagnostic and therapeutic procedures other than those used in routine practice. |
ASTRAZENECA | 2024-06-06 |
| 146 | Anti-Inflammatory Reliever Therapy for Asthma Using Inhaled Budesonide/Formoterol As-needed With or Without Maintenance in South African Children: A Pragmatic Open Label Phase 3 Randomised Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 3 single-centre open label randomised controlled trial with two equal sized groups to assess the efficacy of budesonide/formoterol 80/4.5 (6-11 years) and 160/4.5 (12-18 years) compared to the standard of care in reducing asthma exacerbations over 52 weeks. Children and adolescents with a diagnosis of asthma or newly diagnosed with asthma will be screened for eligibility for enrolment. Those who had an asthma exacerbation in the previous year will be randomised 1:1, to either receive budesonide/formoterol inhaler for both symptom relief and for chronic anti- … |
UNIVERSITY OF KWAZULU | 2024-06-06 |
| 147 | Impact of Breathing Exercises on Lung Function in Chronic Airway Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: aim of this study is to evaluate the efficacy of pulmonary rehabilitation program as a non-pharmacological treatment method to: Improve functional capacity as assessed by six-minute walking distance (6MWD) test. Improve dyspnea level as assessed by Medical Research Council (MRC) dyspnea scale. Improve pulmonary function tests and arterial blood gas. |
MOHAMED ABD ELMONIEM MOHAMED; | 2024-06-01 |
| 148 | A Randomized, Double-blind, Parallel Group, Multi-center Study to Evaluate The Long-term Safety of Salbutamol Rescue Medication When Administered Via Metered Dose Inhalers Containing The Propellant HFA-152a or Reference HFA-134a PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to assess and compare the safety and tolerability of salbutamol administered via metered dose inhaler (MDI) containing propellant 1,1-difluoroethane (HFA-152a) or 1,1,1,2-tetrafluoroethane (HFA-134a) in participants aged \>=18 years with asthma |
AARON WEINBERG; | 2024-05-31 |
| 149 | Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: the use of pressure wires is the standar of care to evaluate angiographically intermediate coronary lesions, however, limitations in the management of these type of lesions continue to be a challenge for the interventional cardiologist. The use of FFR has some limitations such as the use of adenosine due to its cost, adverse effects (e.g. transient atrioventricular block, angina, headache, etc.), time consuming and some relative contraindications for its use. In this sense, in recent years new rest indices (iFR, RFR, dPR) and hyperemic indices without adenosine (cFFR-NTG, Pd/Pa-NTG or cFFR) have been developed, … |
FUNDACIÓN EPIC | 2024-05-31 |
| 150 | Effects of Web-Based Education on Patient Empowerment and Asthma Control in Asthma Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is defined as a chronic inflammatory disorder of the airways associated with an extreme increase in airway hyperresponsiveness leading to recurrent wheezing, shortness of breath, chest tightness, and coughing attacks. The World Health Organization states that approximately 339 million individuals worldwide have asthma and more than 400 thousand deaths occur due to asthma every year. With effective and sustainable asthma management, it is possible to reduce disease-related complaints, admissions to emergency units and hospitalizations, limit the physiological and psychological effects of the disease, prevent dependence on healthcare professionals and caregivers, … |
NESLIHAN KOMSER; | 2024-05-30 |
| 151 | A Phase 1, Randomized, Open-label, Single Dose, 2-treatment Arm (200 Μg and 800 Μg), 4-way Crossover Study in Healthy Participants Aged 18 to 55 to Compare The Pharmacokinetics of Salbutamol Administered Via Metered Dose Inhalers Containing Propellants HFA-152A (Test) and HFA-134A (Reference) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to characterize the PK of single doses of salbutamol in healthy participants delivered via an MDI containing propellant HFA-152a (test), and to compare with an MDI containing propellant HFA-134a (reference). |
JEROEN VAN DE WETERING; | 2024-05-27 |
| 152 | A Phase 2, Randomized, Double-blind, Placebo-controlled, Dose Ranging Study to Assess The Efficacy and Safety of Rocatinlimab in Adult Subjects With Moderate-to-severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to describe the efficacy of rocatinlimab in reducing asthma exacerbations. |
AMGEN | 2024-05-24 |
| 153 | A Randomized, Double-blind, Multicenter, Parallel-group, Phase IIIb 52 Week Study Evaluating The Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma (ACADIA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the effect of budesonide/albuterol metered-dose inhaler (BDA MDI) with albuterol sulfate metered-dose inhaler (AS MDI), both administered as needed, on the annualized rate of severe asthma exacerbations in adolescents with a documented clinical diagnosis of asthma and at least one severe exacerbation in the prior year. |
ASTRAZENECA | 2024-05-20 |
| 154 | Effectiveness of A Dietary Supplement Based on A Synergistic Combination of Beta-Glucans and Saccharomyces Cerevisiae Yeast Enriched With Zinc and Selenium in Allergic Patients Undergoing Subcutaneous Immunotherapy Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study will attempt to determine if the dietary supplement, based on a synergistic combination of β-glucans and Saccharomyces cerevisiae yeast enriched with Zinc and Selenium, can improve the immune response in allergic patients diagnosed with rhinitis or rhinoconjunctivitis, with or without controlled asthma, who are undergoing subcutaneous polymerized 100 immunotherapy with a rapid initiation protocol. It will also attempt to determine if the dietary supplement in combination with DAO enzyme could improve the immunological response to immunotherapy. |
JUAN ANTONIO CARRILLO; | 2024-05-20 |
| 155 | Role of Pharmaceutical Pictograms in Disease Management: A Mix Method Study of Various Stakeholders in Pakistan PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate newly developed pictogram cards and their utility in improving inhaler techniques in asthmatic patients. |
KANZA ARSHAD; | 2024-05-10 |
| 156 | Evaluation of Alterations in The Gut Microbiota in Bronchial Asthma: A Feasibility Study in A Pediatric Population in The Alexandria Area PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma constitutes a major chronic noncommunicable disease, globally it affects about 300 million people and the incidence has been steadily increasing in recent decades; it affects about 10% of children and is the leading chronic disease in childhood. The microbiota constitutes the collection of all microorganisms-bacteria, viruses, fungi, protozoa-that live in symbiosis with our bodies. Disruption of the microbiota during this critical period of development can cause asthma, allergies, and other immunological disorders. Therefore, … |
AZIENDA OSPEDALIERA SS ANTONIO E BIAGIO E CESARE ARRIGO DI ALESSANDRIA | 2024-05-06 |
| 157 | Early Treatment of Heart Failure: A Non-interventional Study Program of Patients With Heart Failure and Initiated on Dapagliflozin (EVOLUTION-HF DEallEF) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure (HF) is a global, public health issue that affects more than 63 million people worldwide; this burden is expected to increase substantially as the population ages. Despite advancements in treatment, a HF diagnosis still leads to significant morbidity and mortality; there is also an immense impact on patients’ health-related quality of life (HRQoL). Dapagliflozin was recently granted approval for heart failure by the European Commission, regardless of ejection fraction and whether the patient has diabetes. Real-world observational data are necessary to describe dapagliflozin use in real-world settings in order to assess treatment patterns, … |
ASTRAZENECA | 2024-04-25 |
| 158 | Patient Characteristics, Treatment Patterns and Outcomes of Patients Enrolled in The Tezepelumab Patient Access Programme; A Retrospective, Observational Medical Chart Review Conducted in UK Severe Asthma Centres PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective, observational chart review that will include patients with severe asthma (SA) who have participated in the tezepelumab patient access programme (TPAP). Electronic case report forms (eCRFs) will be used for data abstraction of clinical information from the health records of patients enrolled in the TPAP from eight NHS acute trusts. Approximately 200 patients with SA who took part in the TPAP with an index date (defined as the date of administration of the first dose of tezepelumab) between 1st January 2023 and 19th July 2023, … |
ASTRAZENECA | 2024-04-22 |
| 159 | Remote Patient Monitoring Solution for Chronic Respiratory Disease Management PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim: To evaluate the use of AeviceMD Monitoring System (AeviceMD) asthma in reducing acute exacerbation. Methodology: Using a randomized controlled trial design, this project aims evaluate the effectiveness of AeviceMD in improving patients’ outcomes in terms of reducing exacerbation, healthcare utilization, improving quality of life, self-efficacy, and cost effectiveness. Paediatric patients above age 7 and adults will be recruited. The data follow-up period is 3 months. It will also evaluate the usability of the device from both patients’ and clinicians’ perspective. 180 patients (124 adults, … |
MABEL LEOW QI HE; | 2024-04-20 |
| 160 | Combined Effects of Inspiratory Muscles Training With Pilate Training on Dyspnea Cardiorespiratory Fitness Quality of Life in Asthma Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a chronic (long-term) condition that affects the airways in the lungs. The airways are tubes that carry air in and out of your lungs. In asthma the airways can become inflamed and narrowed at times. This makes it harder for air to flow out of your airways when you breathe out. When symptoms get worse, it is called an asthma attack. There is no permeant cure for asthma, but medical treatment and physiotherapy treatment can help to manage it. There is many physiotherapy protocols can be used for asthma patients like aerobic exercises, … |
SUMERA HAMEED; | 2024-04-20 |
| 161 | A Phase 4, 52-week (Primary Analysis at 24-weeks), Randomized, Stratified, Open-label, Active-controlled, Parallel-group, Effectiveness Study, Comparing FF/UMEC/VI With Non-ellipta Usual Care (ICS/LABA) in Adult Participants With Uncontrolled Asthma PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to assess and compare the effectiveness of fluticasone furoate/umeclidinium bromide/vilanterol trifenatate (FF/UMEC/VI) with inhaled corticosteroids/long-acting beta-2 agonists (ICS/LABA) in adult participants with uncontrolled asthma |
GLAXOSMITHKLINE | 2024-04-16 |
| 162 | Biochemical Role of Long Non-coding RNA MALAT 1 and Serum Tumor Necrosis Factor Alpha in Bronchial Asthma Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchial asthma affects more than a quarter of a billion people worldwide. It is responsible for over 1000 deaths a day, of which the majority are preventable (Levy, 2015). Asthma is a common heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of variable respiratory symptoms, such as shortness of breath, chest tightness, wheezes, and cough, together with variable expiratory airflow limitation. Airflow limitation may later become persistent (GINA, … |
ZAINAB MAHMOUD KADRY; | 2024-04-16 |
| 163 | Pivotal Study of The Performance and Safety of The Pneumoscope Device in Adults and Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Respiratory diseases are associated with high morbidity and mortality worldwide. Proper diagnosis and risk assessment of these conditions are essential for optimal management. Clinicians use three particularly useful tools to identify these conditions when assessing the patient’s status: the stethoscope, the pulse oximeter, and the thermometer. The Pneumoscope is an all-in-one device including a digital stethoscope, a pulse oximeter, and a thermometer. This study aims to assess the performance and safety of the Pneumoscope in recording respiratory sounds, body temperature, non-invasive blood oxygen saturation levels and heart rate in children and adults. |
JOHAN N SIEBERT; | 2024-04-15 |
| 164 | The Effects of Positive Airway Pressure on The Mucolytic Effects of NAC PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic Obstructive Pulmonary Disease (COPD). The main questions it aims to answer are: * Does delivery of aerosolized NAC with positive inspiratory pressure have a greater effect on mucus plug burden in the lungs than delivery of NAC without positive pressure. * Does delivery of aerosolized NAC with positive inspiratory pressure have a greater effect on lung function than delivery of NAC without positive pressure. Participants will be assigned (in a single blind design) to the NAC via jet nebulizer group or the NAC via AeroEclipse-VersaPAP nebulizer group. Participants will each complete 5 treatment visits over the course of 30 days. Each treatment visit will consist of two treatments of a 10% NAC (3 mL) and 2.5 mg albuterol (0.5mL) inhalation solution separated by 4 hours, via the nebulization method specific to their group. |
JOHN FAHY; | 2024-04-09 |
| 165 | Asthma Link: A Partnership Between Pediatric Practices, Schools, and Families to Improve Medication Adherence and Health Outcomes in Children With Poorly Controlled Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this cluster Randomized Control Trial is to determine the effectiveness of Asthma Link, a school supervised asthma therapy program, compared with an educational asthma workbook, in improving asthma symptoms for children with poorly controlled asthma aged 5-14. |
MICHELLE TRIVEDI; | 2024-04-04 |
| 166 | Effectiveness of An Evidence-based Intervention to Promote Smoke-free Homes: A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: While smoking and exposure to second-hand tobacco smoke (SHS) in most public places is addressed by smoke-free regulations, the exposure to SHS at private places, such as homes, is still prevalent in Spain and represents a significant public health challenge. Main objective of the study: to evaluate the effectiveness of an evidence-based intervention to create smoke-free homes in households with children. Design: cluster randomised controlled trial. Target population: families with children (≤18 years old) and at least one smoker who allow smoking in the home. Sample: 416 participants, … |
ESTEVE FERNÁNDEZ; | 2024-04-02 |
| 167 | An Open Label, Single Dose, 3-Period, Crossover Study to Determine The Pharmacokinetic Profile and Safety of Fluticasone Propionate/Albuterol Sulfate (Fp/ABS) Multidose Dry Powder Inhaler With E-Module (eMDPI) Compared to Fluticasone Propionate Multidose Dry Powder Inhaler (Fp MDPI) in Participants With Asthma (4 to 11 Years Old) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objectives of this study are: – To determine the pharmacokinetic (PK) profile of fluticasone propionate (Fp) and albuterol sulfate (ABS), delivered in combination, from a single dose of TEV-56248 (Fp and ABS multidose dry powder inhaler with e-module [Fp/ABS eMDPI]) in participants with asthma – To compare the PK profiles of Fp for 2 different dose strengths of TEV-56248 to that of fluticasone propionate multidose dry powder inhaler (Fp MDPI) – … |
TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D | 2024-04-02 |
| 168 | Telehealth-Enhanced Asthma Care for Home After The Emergency Room (TEACH-ER) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators propose a randomized controlled trial of Telehealth-Enhanced Asthma Care for Home After the Emergency Room (TEACH-ER) vs. enhanced care (EC). TEACH-ER includes: 1) brief, pictorial, and health literacy-informed asthma education in the ED, with color- and shape-coded labels provided for home asthma medications; 2) virtual primary care follow-up within 1 week of discharge using in-home telemedicine (Zoom) when possible, featuring provider prompts for guideline-based preventive therapy and home delivery of prescribed medications with pictorial action plans; 3) two additional in-home virtual visits to reinforce teaching, review treatment plans, label medications, … |
SEAN FREY; | 2024-04-01 |
| 169 | Efficacy and Safety of Continuous Versus Intermittent Nebulization of Salbutamol in Acute Severe Asthma in Children Under 12 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma affects around 260 million people globally, causing around 0.5 million deaths annually. Pediatric asthma remains a major global public health challenge, significantly affecting the quality of life for many children. Therefore, this study was planned to compare the effects of continuous versus intermittent nebulization of salbutamol in the treatment of acute severe asthma (ASA) in children visiting the emergency department of a tertiary childcare hospital in South Punjab, Pakistan. |
MUHAMMAD AAMIR LATIF; | 2024-04-01 |
| 170 | A Phase I Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Dose of SHR-4597 Inhalation in Healthy Subjects and Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this randomized, double-blind, single/multiple ascending dose, placebo-controlled Phase I clinical trial was to evaluate the safety and tolerability of SHR-4597 in healthy subjects and asthmatic patients. The study consists of two parts: Part 1 involves single ascending inhalation dose in healthy subjects; Part 2 involves multiple ascending inhalation dose in asthmatic patients, further divided into Part 2A: multiple ascending inhalation dose in mild to moderate asthmatic patients, and Part 2B: multiple ascending inhalation dose in moderate to severe asthmatic patients. Subsequent lung pharmacokinetic studies of SHR-4597 inhalation will be conducted based on patients’ PKPD data. |
GUANGDONG HENGRUI PHARMACEUTICAL | 2024-04-01 |
| 171 | Continuous Versus Intermittent Nebulization Therapy in Acute Asthma Exacerbation at Emergency Department: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical is to compare treatment outcomes between continuous nebulization and intermittent therapy in the management of acute exacerbation of asthma in the emergency department(ED). Participants will random assign to either continuous or intermittent nebulization. In the continuous group, patients receive budesonide, fenoterol, ipratropium bromide, and normal saline continuously for an hour. In the intermittent group, the same medications are administer every 20 minutes for an hour. Measurements include symptom severity, respiratory rate, oxygen saturation, and pulmonary function tests. Primary endpoints are ED stay length, hospital admission, … |
KUMPOL KORNTHATCHAPONG; | 2024-04-01 |
| 172 | Probiotics and Insulin Resistance in Obese Asthmatics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this pilot study investigators will test the hypothesis that administration of oral probiotics modulates microbiome/metabolome, lowers leptin and insulin resistance and improves clinical parameters of asthma in obese insulin resistant asthmatics. Preliminary studies with oral probiotic administration in obese asthmatics showed increased abundance of probiotics-derived Bifidobacterium species and Bifidobacterium-derived metabolite in the airways of asthmatics. Additionally, neutrophils and IL-17 producing Th17 cells were significantly reduced following probiotics administration. Based on these preliminary studies, … |
JESSY S. DESHANE; | 2024-04-01 |
| 173 | Efficacy of Qigong Exercise on Sleep Quality and Heart Rate Variability in Patients With Fibromyalgia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine any significant efficacy of qigong exercise on sleep quality and heart rate variability in patients with fibromyalgia. |
ALAA WAGEIH AGWA; | 2024-04-01 |
| 174 | A Prospective, Observational, Multicentre Study To Evaluate The Treatment Pattern Of Moderate-to-Severe Asthma Patients In China PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Prospective, Observational, Multicentre Study to describe treatment pattern changes of uncontrolled moderate-to-severe asthma patients in China. Sponsor by Astrazeneca Investment(China) Co., LTD. |
ASTRAZENECA | 2024-03-22 |
| 175 | A Prospective, Real-World, Interventional Study To Evaluate The Effect Of Mepolizumab On Achieving Clinical Remission In Participants With Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, real-world, single arm, global, multi-centre study to evaluate the effect of timely treatment with mepolizumab (NUCALA) to achieve clinical remission in adult participants with severe asthma with an eosinophilic phenotype (SA-EP). |
MINDY DEMARCO; | 2024-03-20 |
| 176 | In Patients With Obstructive Airway Disease, Investigate The Effects of Different Breathing Strategies and Pedaling Rates on The Physiological Response to Bicycle Exercise PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The definition of obstructive airway disease is a ratio of the forced expiratory volume in one second (FEV1) to the forced vital capacity (FVC) of less than 0.7, which includes conditions such as chronic obstructive pulmonary disease, asthma, lymphangioleiomyomatosis, and bronchiolitis obliterans syndrome. For example, lung obstruction adversely affects many aspects of a patient’s health, such as lung function and exercise capacity. Pulmonary rehabilitation is widely used in patients with obstructive airway disease, and the prescription of pulmonary rehabilitation depends on exercise capacity parameters such as peak oxygen uptake (peak VO2), peak workload, and anaerobic threshold. However, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2024-03-20 |
| 177 | Prevalence of The OCS Use Among Severe Asthma Patients in Egypt: A Nation-wide, Cross-Sectional, Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a syndrome characterized by airway inflammation, reversible airway obstruction, and airway hyper-responsiveness. Patients present clinically with recurrent wheezing, shortness of breath, cough, and chest tightness. Asthma is a leading cause of morbidity with a global prevalence of approximately 300 million; it is estimated that the number of people with asthma may increase to 400 to 450 million people worldwide by 2025. Severe asthma is not considered a single disease; instead, it is divided into several phenotypes, owing to the variety of inflammatory, clinical, … |
ASTRAZENECA | 2024-03-12 |
| 178 | Resistive Diaphragmatic Training Versus Volumes Oriented Spirometry On Pulmonary Function Test And Functional Capacity In Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma, a chronic lung disease characterized by airway inflammation and constriction, presents ongoing challenges despite advancements in treatment. The aim of this study to deliver non-pharmacological interventions, particularly comparing resistive diaphragmatic training (RDT) and volume-oriented spirometry, to assess their efficacy in enhancing pulmonary function and functional capacity among asthmatic patients. it will compare resistive diaphragmatic training (RDT) with volume-oriented spirometry in asthmatic patients to pinpoint the superior method for enhancing lung function and daily capabilities. |
QURAT UL AIN; | 2024-03-10 |
| 179 | Pragmatic, Randomized, Controlled Trial of Early Cow’s Milk, Egg, and Peanut Allergen Introduction and Maintenance in Healthy and High-Risk Infants PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Multiple clinical trials have demonstrated that early allergen introduction, feeding babies common food allergens before six months, decreases children’s risk of developing a food allergy. Despite successful food allergy introduction trials showing that food allergies can be prevented, early introduction in the required amount can be challenging for parents. In some studies, less than 20% of parents introduce peanuts before their child is six months old, and few feed them regularly after introduction. Ready. Set. Food! is a direct-to-consumer product that offers a convenient supplement with a daily dose regimen that can be added to breastmilk, formula, … |
KARA MCNAMARA; | 2024-03-07 |
| 180 | Impact of Respiratory Allergy on Response to Initiation of Biotherapy in Severe Asthma in Adult Severe Asthmatic Patients Followed at Poitiers University Hospital on Biotherapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to take stock of the situation of adult patients with severe asthma on biotherapy, followed up at Poitiers University Hospital, and in particular to increase our knowledge of factors predictive of response to biotherapy. The main aim is to improve the management of adult severe asthma patients treated with biotherapy, according to their allergic status. |
POITIERS UNIVERSITY HOSPITAL | 2024-03-01 |
| 181 | The Impact of Different Feeding Modes on Patients With Intracerebral Hemorrhage: Improving Clinical Outcomes and Safety PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter, prospective, randomized controlled clinical trail involved tracheostomized patients with Intracerebral Hemorrhage.The goal of this clinical trial is to compare the clinical effect of Intermittent Oro-esophageal Tube Feeding vs Nasogastric Tube Feeding in Tracheostomized Patients with Intracerebral Hemorrhage. The main questions it aims to answer are: Compared to Nasogastric Tube Feeding, can the Intermittent Oro-esophageal Tube Feeding better improve the nutritional status, extubation of tracheostomy tube, pulmonary infection, neurological deficit of Patients with Intracerebral Hemorrhage Compared to Nasogastric Tube Feeding, is the Intermittent Oro-esophageal Tube Feeding safer. Participants will be divided into two groups randomly, … |
COPKA SONPASHAN; | 2024-03-01 |
| 182 | The Influence of Breathing Pattern on Measurement of Forced Oscillation in Patients With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a chronic respiratory disease characterised by airway inflammation, bronchoconstriction, and airway hyperresponsiveness. Accurate and reliable assessment of lung function is crucial in diagnosing and monitoring asthma. The forced oscillation technique (FOT) is a non-invasive method that has gained attention in recent years as a valuable tool for evaluating respiratory mechanics in asthma. FOT involves applying small amplitude oscillations at various frequencies to the respiratory system and measuring the resulting pressure and flow responses. These measurements provide valuable insights into the mechanical properties of the airways, including resistance, compliance, and reactance. FOT offers several advantages over traditional spirometry, … |
KARL SYLVESTER; | 2024-03-01 |
| 183 | Investigation of The Effects of Aerobic and Core Stabilization Exercises on Primary Dysmenorrhea in High School Female Students PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dysmenorrhea, derived from ancient Greek, translates to ‘difficult monthly flow’ and refers to painful cramps during menstruation, a common cause of pelvic pain. The pain, often in the lower abdomen, results from uterine pressure exceeding 60 mmHg. Symptoms include suprapubic pain, radiating discomfort, nausea, diarrhea, and headache, impacting quality of life. Etiology involves factors like age at menarche, heavy flow, lifestyle, and medical conditions. Dysmenorrhea is categorized as primary (without underlying pathology) or secondary (due to conditions like endometriosis). Its prevalence is high in adolescence, affecting daily life, school, … |
AYCAN ÇAKMAK REYHAN; | 2024-03-01 |
| 184 | Interpreting Respiratory Oscillometry in Adult Asthma and COPD: A Delphi Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an international Delphi study to consolidate expert consensus on the use of respiratory oscillometry in the management of adult patients with asthma or chronic obstructive pulmonary disease (COPD). The primary objective of the Delphi study is to aid the interpretation of respiratory oscillometry in clinical practice amongst adult patients with asthma or COPD. This will be achieved by obtaining expert consensus on: – Which parameters are used in clinical practice for impulse oscillometry (IOS) and for forced oscillation technique (FOT) devices. – … |
LI PING CHUNG; | 2024-03-01 |
| 185 | Evaluation of Cardiopulmonary Parameters in Individuals With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study compare the cardiopulmonary parameters of individuals with asthma with healthy subjects. |
AYDAN ASLI AKSEL UYLAR; | 2024-03-01 |
| 186 | Combined Effects of Lion’s Breath Technique With Chest Percussion Therapy in Pneumonia Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be randomized controlled trial with non-probability convenient sampling. Sample size will be 90,45 in each group. Outcome will be measured by using 6 minute walk test, Spirometry (FVC, FEV1/FVC and PEF), Functional Independence Measure. |
MUHAMMAD FAIZAN HAMID; | 2024-03-01 |
| 187 | The Regulatory Function of Inhaled Asthma Medication Salbutamol on Thermogenesis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years, obesity and its complications have severely threatened human health. Given the limited options for obesity treatment currently available, there is an urgent need to develop new drugs and therapeutic methods to alleviate patient suffering. Mammalian adipose tissue is primarily divided into energy-storing white fat and energy-consuming brown fat. Physical activity, exposure to cold, and other factors induce the transformation of white fat into energy-consuming brown fat, a process known as adipose tissue browning. The occurrence of adipose tissue browning increases the body’s energy expenditure and dissipates it in the form of heat, … |
JUNKUN JIANG; | 2024-03-01 |
| 188 | A Study to Evaluate The Consistency of Oscillometry and Spirometry Test Results in Patients With Confirmed or Suspected Asthma or COPD PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study to evaluate the consistency of oscillometry and spirometry test results in patients with confirmed or suspected asthma or COPD, it is a multi-centre clinical study. sponsor by Astrazeneca Investment(China) Co.,LTD. |
ASTRAZENECA | 2024-02-29 |
| 189 | STEP: A Prospective, Interventional, Multicenter, Single-Arm Phase 3b Study to Evaluate The Step-Down of Maintenance Therapy in Patients With Severe Eosinophilic Asthma Treated With Benralizumab PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, multi-center, single-arm Phase 3b study designed to evaluate the potential benefit to patients if benralizumab treatment could enable reduction in asthma maintenance controllers while allowing patients to maintain asthma control in Chinese patients. |
MIN ZHANG; | 2024-02-28 |
| 190 | A Phase 2, Randomized, Double-blind, Placebo-controlled, Multi-center, Dose-ranging Study to Evaluate The Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and safety of verekitug (UPB-101) in participants with severe asthma. The study will evaluate the incidence of asthma exacerbations, other pharmacodynamic (PD) parameters such as lung function and asthma control, and the safety and tolerability of verekitug (UPB-101) compared to placebo. |
UPSTREAM BIO | 2024-02-27 |
| 191 | A Comparison of Diagnostic Testing Modalities in The Assessment of Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the concordance of international asthma guidelines in the diagnosis of asthma and explore the presence of airways disease using additional non-guideline physiologic criteria, such as IOS, not included in the guidelines, but available in the Portsmouth lung function service. |
ANOOP CHAUHAN; | 2024-02-26 |
| 192 | A Randomized, Double-Blind, Placebo-Controlled Single Ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of IBI3002 in Healthy Participants and Participants With Mild to Moderate Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, randomized, double-blind, placebo-controlled, phase 1, single-ascending-dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of IBI3002 in healthy participants and mild to moderate asthmatics. Subjects will be randomly assigned to different dosages of IBI3002 and matched placebo groups. The entire trial cycle includes a 4-week screening period, 1-day treatment period and 5-week follow-up period. |
INNOVENT BIOLOGICS SUZHOU | 2024-02-26 |
| 193 | A Retrospective Chart Review to Investigate Clinical Remission in Patients With Severe Asthma Treated With Biologics in The United Kingdom National Health Service PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a common lung condition that causes occasional breathing difficulties and affects around 5.4 million people in the UK of all ages. Common symptoms can include wheezing when breathing, breathlessness, a tight chest and coughing. However, these symptoms can get worse and lead to an asthma attack which can be fatal. There is currently no cure for asthma but there are treatments that can help keep the symptoms under control. The main types of treatment include reliever inhalers used when needed quickly to reverse asthma symptoms for a short time, … |
ASTRAZENECA | 2024-02-22 |
| 194 | Inclusion of Calcifediol in The Hospital Therapeutic Protocol for Treatment of SARS-CoV-2 Disease (COVID-19). Mortality Analysis. Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome variables, such as admission to the Intensive Care Unit (ICU), to Gerencia de Atención Integrada (GAI) de Albacete. Complejo Hospitalario Universitario de Albacete. Albacete (Spain), based on the files of the MXXI medical records, Information System of the Laboratory (ISL) and Pharmacy. |
COMPLEJO HOSPITALARIO UNIVERSITARIO DE ALBACETE | 2024-02-21 |
| 195 | Impact of Covid-19 on Occupational Dermato-allergology Consultations of Health Peronnel PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Occupational dermatitis is the second most common occupational disease in Europe, with a notable prevalence among healthcare workers-approximately 20% of whom are affected. However, these figures may be underestimated due to underreporting. Despite the presumed scale of the problem, … |
CENTRE HOSPITALIER INTERCOMMUNAL CRETEIL | 2024-02-19 |
| 196 | Effects of Liuzijue Exercise Versus Tai Chi Chuan Exercise in Improving Dyspnea Index and Pulmonary Function in Patients With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To analyze either Liuzijue exercise or Tai Chi Chuan exercise is effective in improving dyspnea index and pulmonary function in patients with asthma. In the general population, the rate of asthma is increasing day by day because of environmental and occupational risk factors which is becoming a burden. It causes shortness of breath, decreases lung volume, and disturbs quality of life. This study aims to improve dyspnea index, lung volume and quality of life of the patients with asthma. |
MEHWISH WASEEM; | 2024-02-15 |
| 197 | Making Elective Caesarean Safer for Infant’s Lungs By Reducing Respiratory Distress Using Knee-chest-flexion: A Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Planned caesarean birth is a risk factor for the development of neonatal respiratory distress commonly known as transient tachypnoea of the newborn. This is due to the absence of labor physiology which facilitates the clearance of fetal lung fluid. We hypothesized that by mimicking flexion induced by uterine contractions by manually performing knee-to-chest flexion directly at birth to achieve expulsion of excess lung liquid, … |
BARIKI MCHOME; | 2024-02-14 |
| 198 | Prevalence of Obstructive Sleep Apnea and Accuracy of Type 3 Home Sleep Apnea Test for Obstructive Sleep Apnea Diagnosis in Difficult-to-treat Asthma: Cross Sectional Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: cross sectional cohort study enroll Patients diagnosed with difficult-to-treat asthma, aged over 18 years, and experiencing persistent symptoms as assessed by the Asthma Control Test (ACT) underwent type 1 in-laboratory polysomnography and type 3 HSAT within 1 month apart |
TIDARAT SOMRUESAEN; | 2024-02-07 |
| 199 | An Open-Label, Two-Part Sequential Study Designed to Assess The Mass Balance Recovery, Absorption, Metabolism, Excretion of [14C]AZD4604 and The Absolute Bioavailability of AZD4604 in Healthy Male and Female Subjects Related Papers Related Patents Related Grants Related Experts View Highlight: The Sponsor is developing the test medicine, AZD4604, as a potential treatment for asthma. Asthma is a common lung condition caused by inflammation (swelling) of the breathing tubes that carry air in and out of the lungs, causing occasional breathing difficulties such as wheezing, shortness of breath, chest tightness and cough. This study in healthy volunteers will explore the following questions. – Does the test medicine cause any important side effects? – What are the blood levels of the test medicine and how quickly does the body get rid of it? – … |
SOMASEKHARA MENAKURU; | 2024-02-06 |
| 200 | Efficacy of A Phone Application on Treatment Adherence in Asthmatic Patients in Upper Egypt PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: asthma adherence is mandatory for disease control |
ENTSAR HSANEN; | 2024-02-01 |
| 201 | Cross Cultural Validation of Urdu Version of Leicester Cough Questionnaire (LCQ) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Leicester Cough Questionnaire (LCQ) is a patient reported, 19-item tool, and it comprised physical, psychological, and social elements. The objective of the study is to cross culturally adapt LCQ in Urdu language and to find the reliability and validity in patients of COPD. It is a three-stage study. Leicester Cough Questionnaire (LCQ) will be adapted in Urdu and will be first tested for its content validity by using content validity index (CVI). In the second stage, the Urdu version of the Leicester Cough Questionnaire (LCQ) will be pilot run; tested for its validity and reliability. In the third stage, … |
WAJEEHA ZIA; | 2024-02-01 |
| 202 | Individualizing Treatment for Asthma in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a patient level randomized trial for teenagers and adults with asthma who will be randomized to four arms – enhance usual care, rescue inhaled corticosteroids, azithromycin and both rescue inhaled corticosteroids and azithromycin. Participants in all arms will be offered access to an online asthma symptom monitoring system. |
WILSON D PACE; | 2024-02-01 |
| 203 | Intermittent Oro-esophageal Tube Feeding Vs Nasogastric Tube Feeding in Tracheostomized Patients With Intracerebral Hemorrhage: Improving Clinical Outcomes and Safety PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter, prospective, randomized controlled clinical trail involved tracheostomized patients with Intracerebral Hemorrhage.The goal of this clinical trial is to compare the clinical effect of Intermittent Oro-esophageal Tube Feeding vs Nasogastric Tube Feeding in Tracheostomized Patients with Intracerebral Hemorrhage. The main questions it aims to answer are: Compared to Nasogastric Tube Feeding, can the Intermittent Oro-esophageal Tube Feeding better improve the nutritional status, extubation of tracheostomy tube, pulmonary infection, neurological deficit of Patients with Intracerebral Hemorrhage Compared to Nasogastric Tube Feeding, is the Intermittent Oro-esophageal Tube Feeding safer. Participants will be divided into two groups randomly, … |
ZENG CHANGHAO; | 2024-02-01 |
| 204 | Investigation of Mandibular Movement Capacity, Cervical Proprioception, Posture and Quality of Life in Adolescents With Nocturnal Bruxism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the effects of bruxism on mandibular movement capacity, cervical proprioception, posture and quality of life in adolescents diagnosed with nocturnal bruxism (clenching and grinding teeth while sleeping) between the ages of 13-18 and to compare them with healthy adolescents. Method: A total of 40 adolescents, 20 with nocturnal bruxism and 20 healthy, will be included in the study. Mandibular movement capacity will be evaluated with a caliper and ruler, cervical proprioception with a CROM device, posture with the New York Posture Scale, … |
METEHAN YANA; | 2024-02-01 |
| 205 | A Randomized, Double-Blind, Vehicle-Controlled, First-in-Human Safety, Tolerability and Proof-of-Concept Study of Topical ATR12-351 in Adults With Netherton Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this clinical trial are to evaluate the safety and tolerability of topically applied ATR12-351, to understand what the body does to ATR12-351, and to observe treatment benefits of the drug in approximately 12 adult patients with Netherton Syndrome (NS). ATR12-351 will be applied to skin lesions on one side of the body, while the vehicle control will be applied to similar lesion on the other side of the body twice daily for 2 weeks. |
AZITRA | 2024-02-01 |
| 206 | Effect of Halotherapy (Salt Therapy) on Oxygen Saturation (SPO2), Asthma Symptoms and Treatment Need in Children With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Asthma is a chronic respiratory disease that can affect all age groups and is characterized by episodic and reversible wheezing, shortness of breath, chest tightness and cough attacks. According to a 2016 report by the United States Department of Disease Control and Prevention (CDC), the prevalence of asthma was 9.6% in children aged 5-11 and 10.5% in children aged 12-17. It has been shown that the prevalence of asthma under the age of 18, which concerns all childhoods, is 8.3%. Purpose: The aim of the study is to determine the effect of salt therapy rooms on the oxygen saturation, … |
EDA GULBETEKIN; | 2024-02-01 |
| 207 | Association Between Cytokines Gene Single Nucleotide Polymorphisms and Type 2 Inflammatory Asthma in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To further understand the role of gene single nucleotide polymorphism (SNP) in the occurrence of type 2 inflammation-related asthma in children by analyzing the gene single nucleotide polymorphism (SNP), lung function and type 2 inflammation indicators of children diagnosed with asthma in outpatient and inpatient. To provide a theoretical basis for the study of personalized treatment and prevention strategies for asthma. |
LI-HONG SUN; | 2024-01-30 |
| 208 | Comparative Effects of Papworth Technique Versus Pranayama in Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a chronic and heterogeneous disease characterized by reversible airway obstruction, airway inflammation and bronchial damage causing dyspnea, wheezing, chest tightness, coughing and impaired quality of life. Papworth technique and Pranayama modify the pattern of breathing to reduce the hyperventilation resulting in normalization of CO2 levels, reduction of bronchospasm and resulting breathlessness .These techniques also change the emotional stresses, improve the immunity system and improve the strength /endurance of respiratory muscles. After taking the consent form from the participants, … |
SIDRA AFZAL; | 2024-01-15 |
| 209 | Effects of Swedish Massage Prior Circuit Breathing Training on Asthma Control and Respiratory Function in Patients With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study was to determine the effects of Swedish massage prior circuit breathing training on asthma control and respiratory function in patients with asthma. |
WANNAPORN TONGTAKO; | 2024-01-15 |
| 210 | Voice Analysis in Asthmatic Patients and Healthy Individuals: Comparative Evaluation of Asthma Control Levels and Voice Characteristics with Machine Learning Models PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma can lead to various factors that impair voice production, including airway restriction, inflammation, and mucus production, resulting in changes in voice frequency and amplitude. Therefore, voice analysis may serve as an indicator of respiratory diseases. A national, observational, case-control study is planned in Türkiye to analyze differences in voice between healthy subjects and asthmatic patients and to assess voice analysis techniques for determining an effective biomarker for asthma control using a machine learning model. |
MED CASE | 2024-01-09 |
| 211 | A Transnational Study to Describe Asthma Patient Clinical Characteristics, Treatment Patterns, Biomarkers and to Identify Phenotypes and Endotypes Associated With Differential Outcomes That May Support Future Development of Personalized Treatment Strategies in Chinese Population PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A Translational Study to Describe Asthma Patient Clinical Characteristics, Treatment Patterns, Biomarkers and to Identify Phenotypes and Endotypes associated with Differential Outcomes that may Support Future Development of Personalised Treatment Strategies in Chinese Population |
ASTRAZENECA | 2024-01-08 |
| 212 | A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Assess The Efficacy and Longterm Safety of Dupilumab in Children 2 to <6 Years of Age With Uncontrolled Asthma And/or Recurrent Severe Asthmatic Wheeze PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a parallel, Phase 3, 2-arm study to evaluate the efficacy and long-term safety of dupilumab treatment in children 2 to \<6 years of age with uncontrolled asthma and/or recurrent severe asthmatic wheeze. The study will be conducted in 2 parts. Part A will be a 52-week, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of dupilumab in children aged 2 to \<6 years old with uncontrolled asthma and/or recurrent severe asthmatic wheeze. At the end of Part A, all eligible participants will be offered participation in Part B, ... |
MICHELE GHEZZI; | 2024-01-03 |
| 213 | Respiratory Rehabilitation and The Impact of Psychiatric Comorbidities PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with respiratory insufficiency, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, asthma, bronchiectasis, and, to a lesser extent, other pathologies that result in respiratory insufficiency and require rehabilitation are admitted to in-hospital Respiratory Rehabilitation. Several studies have assessed the impact of comorbidities in the most frequent respiratory diseases such as COPD, asthma, pulmonary fibrosis, and cystic fibrosis in terms of worsening mortality, morbidity, and disease progression. However, to our knowledge, … |
MICHELE VITACCA; | 2024-01-02 |
| 214 | Efficacy of Physiological Saline and Probiotics (LiveSpo Navax) in Preventing Respiratory Diseases in Children Aged 2-5, in Son Tay Province, Hanoi PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute respiratory infections are common diseases worldwide with the highest incidence and mortality rates, especially among children. Currently, the prevention of acute respiratory infections in children still faces certain limitations. Although there is a vaccine available for influenza, there are no vaccines yet for RSV and adenovirus in children, and influenza vaccination needs to be repeated annually to achieve optimal effectiveness. Therefore, maintaining respiratory and throat hygiene is essential for both treatment and prevention, ensuring respiratory health for children and reducing the risk of bacterial co-infections. In recent years, preventive strategies for respiratory inflammation have garnered increasing attention, … |
THU TH NGUYEN; | 2024-01-02 |
| 215 | Cognitive and Emotional Factors Relation to Treatment Adherence in Asthmatic Patients in Upper Egypt PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-adherence to controller therapy is one of the main reasons of poor asthma control. Adherence to medication in different studies range between 30 and 70% . Several factors related to the disease, to the patient, treatment or physician- patient relationship |
ENTSAR HSANEN; | 2024-01-01 |
| 216 | The Study About The Identification of Treatable Traits of Severe Asthma and The Construction of Personalized Treatment System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe or uncontrolled asthma is a complex heterogeneous disease, in which patients may exhibit different types of airway inflammation and often accompany multiple comorbidities and risk factors. Identifying potential modifiable factors that influence prognosis, i.e., treatable traits, and targeting these traits for individualized, bundled management of patients may help improve the quality of life of asthma patients and enhance asthma control levels. This project aims to investigate the distribution of treatable traits in uncontrolled asthma patients in Beijing by conducting pulmonary function tests, exhaled nitric oxide tests, blood tests, allergen IgE tests, and chest CT scans, … |
KEWU HUANG; | 2024-01-01 |
| 217 | A Study Evaluating The Use of ResAppDx V2.0 As An Aid to Diagnose Respiratory Disease in Adolescent and Adult Patients in An Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim is to to demonstrate that the ResAppDx v2.0 algorithms provide an accurate diagnosis of respiratory disease in the study’s clinical setting compared to a clinical adjudication committee’s (CAC) diagnosis; … |
MOHAMED DR ABDALLA; | 2024-01-01 |
| 218 | A Study Evaluating The Use of ResAppDx V2.0 As An Aid to Diagnose Respiratory Disease in Paediatric Patients in An Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of study is to demonstrate that the ResAppDx v2.0 algorithms provide an accurate diagnosis of paediatric respiratory disease in the study’s clinical setting compared to a Clinical Adjudication Committee’s (CAC) diagnosis; and to establish a baseline for the resource use and cost of current care pathways for paediatric respiratory disease diagnosis in an emergency department. Eligible subjects/parents will be assented/consented, … |
RESAPP HEALTH | 2024-01-01 |
| 219 | Timely Administration of IV Magnesium Sulfate in Patients With A Moderate Asthma Exacerbation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to identify whether early administration of magnesium sulfate in moderate asthma exacerbations can potentially avoid admission, decrease length of stay in the emergency department (ED), decrease length of stay (LOS) in the general hospital floor vs pediatric intensive care unit (PICU), and decrease the need for respiratory support. |
RYAN MCKEE; | 2024-01-01 |
| 220 | Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline for Children in The Management of Acute Exacerbation of Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to fill this gap by comparing the effectiveness of intravenous magnesium sulfate versus terbutaline in children with acute asthma exacerbations, providing evidence-based guidance for clinicians in emergency settings. |
MUHAMMAD AAMIR LATIF; | 2024-01-01 |
| 221 | Main Occupational Health Hazards Among Workers Of Superphosphate Fertilizer Factory in Assiut and Evaluation of A Health Education Program On Dangers of Respirable Chemicals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims: – To identify the main occupational health hazards to which the superphosphate fertilizer industry workers are exposed. – To identify the respiratory and auditory health effects of these hazards and associated risk factors among those workers. – To clarify the knowledge, attitudes, and practices of workers towards the chemical health hazards affecting the respiratory system (dust and hazardous gases). – To assess the effect of health education program on workers’ knowledge, attitudes, and practices towards these hazards and the use of personal protective equipment (PPE). |
ISRAA SALAH EL-DIN SHAKER; | 2024-01-01 |
| 222 | The Clinical Indexes and Efficacy of Qi-pian in Patients With Allergic Rhinitis With or Without Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Allergic rhinitis and asthma are common respiratory diseases. Qipian® is a Chinese medicine made from three types of bacteria, used to treat these conditions. This study will retrospectively analyze the effects of adding Qipian® to the regular treatment for patients with allergic rhinitis, with or without asthma. Patients meeting the Allergic Rhinitis and its Impact on Asthma（ARIA） and Global Initiative for Asthma（GINA） diagnostic criteria were divided into two groups: one receiving standard drug treatment, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2024-01-01 |
| 223 | Comparison of Salbutamol Alone and Salbutamol in Combination With Ipratropium Bromide in Treatment of Acute Asthma in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial was to determine if adding ipratropium bromide to salbutamol improves asthma treatment in children. The main question this study aimed to answer was: Does combining ipratropium with salbutamol improve asthma symptoms more effectively than salbutamol alone? Researchers compared salbutamol alone to a combination of salbutamol and ipratropium in children with acute asthma. Participants: (i) Received either salbutamol alone or salbutamol with ipratropium via nebulization for 4 hours (ii) Had their asthma symptoms assessed before and after treatment (iii) Were discharged with continued treatment and counseling if stable This study was conducted in the Department of Pediatric Medicine, Children’s Hospital Multan, over six months. A total of 60 children with acute asthma were included. |
MUHAMMAD UMAIR; | 2024-01-01 |
| 224 | Pembangunan Dan Keberkesanan Modul Intervensi Berasaskan Sensori Dalam Kalangan Kanak-kanak Dengan Autisme / The Development and Effectiveness of Sensory-based Intervention Modules in Children With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the effectiveness of Sensory-based intervention modules on children with Autism Spectrum Disorder (ASD). The main questions this study aims to answer is How do children with ASD respond to Sensory-based intervention (SBI) in terms of their sensory processing, social skills, and play? Thus, the objective of this study is to determine the significant differences in sensory processing, social skills, and play in children with ASD before and after receiving the Sensory-based intervention (SBI) module in the intervention and control groups. Participants in this study are children with ASD, … |
NATIONAL UNIVERSITY OF MALAYSIA | 2024-01-01 |
| 225 | Effects of Video Game-Based and Conventional Breathing Exercises on Pulmonary and Extrapulmonary Features in Children With Asthma: A Randomized Comparative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Conventional breathing exercises are recommended as a support to drug therapy, which is the primary treatment modality for symptom management in asthma patients. Video game-based applications are current approaches that enable exercises to be performed more fun, motivating, freely, … |
HIKMET UCGUN; | 2024-01-01 |
| 226 | Clinical Efficacy of Saffron Mouth Rinse in Periodontitis Patients With Renal Disease: A Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The commensal oral bacteria are responsible for the initiation and propagation of the disease through the process of dysbiosis, or microbial imbalance. The disease proceeds cyclically with periods of activity and quiescence until therapeutic action is taken, or the tooth and surrounding structures are destroyed by the disease process that may result in the loss of the tooth. As periodontal disease progresses from gingivitis to periodontitis, a greater number of anaerobic organisms colonize deeper periodontal pockets, such as Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, which triggers the host inflammatory response. This response includes the production and dissemination of C-reactive protein (CRP), … |
DALIA GHALWASH; | 2024-01-01 |
| 227 | Investigating The Effects of Th2 Modulation on The Generation and Persistence of Tissue Adaptive Immune Memory in Chronic Rhinosinusitis With Nasal Polyposis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic rhinosinusitis (CRS) is a condition of persistent sinonasal mucosal inflammation which affects 11.9% of the US population. Mepolizumab is newly approved to treat chronic rhinosinusitis with nasal polyps (CRSwNP, the spaces inside nose and head are swollen and inflamed) and acts booking interleukin-5 (IL-5) a protein implicated in the inflammatory process. We aim to use Single-cell RNA sequencing (RNA-Seq, a method of genetically ‘barcoding’ cells to allow gene expression to be profiled at the level of individual cells) to study the effects of IL-5 blockade on the generation and maintenance of nasal adaptive immune responses, in CRS subjects. |
ANDREW THAMBOO; | 2024-01-01 |
| 228 | Effect of The Aerobika Oscillating Positive Expiratory Pressure (OPEP) Device on Mucus Plugging and Airflow Obstruction in Patients With Moderate-to-severe Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to evaluate the effect of daily AerobikaTM Oscillating Positive Expiratory Pressure (OPEP) device use on mucus plugging and airway function in adult patients with moderate-to-severe asthma. |
SARAH SVENNINGSEN; | 2024-01-01 |
| 229 | A Phase III, Multicentre, Randomized, Double-blind, Single-Dose, 2-Arm, 2-Period, Crossover Study to Investigate The Efficacy of PT027 Compared With Placebo on Exercise-Induced Bronchoconstriction in Adult Patients With Asthma (BREATH) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this Phase III, multicentre, randomized, double-blind, single-dose, 2-period, crossover study is to assess the efficacy and safety of PT027 (budesonide/albuterol sulfate) metered-dose inhaler compared with placebo on exercise-induced bronchoconstriction in adult patients with asthma. Subjects will receive each study treatment on separate visits and undergo a treadmill exercise challenge test so that the effect of study treatment on exercise-induced bronchoconstriction can be evaluated |
ASTRAZENECA | 2023-12-22 |
| 230 | Randomized, Controlled Study to Evaluate The Effectiveness of The Kata® Inhalations-App in Reducing Critical and Non-critical Handling Errors and Improving Adherence to Prescribed Drug Inhalation Therapy and Asthma Control in Adult Patients with Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Kata® App is a digital therapy assistant for patients with asthma who need to inhale their therapy. Kata features inhalation trainers that shows patients in a simple and understandable way how to improve their inhalation maneuver so that the drug reaches the lungs efficiently. The Kata® App aims to reduce inhalation errors and ensures that inhaled drugs are used as approved and prescribed. Kata has different trainers for different inhalation devices. This study investigates the possible positive effects of the Kata® Inhalation App. The main goal of the study is to: 1. investigate the effect of using the Kata® App on adherence for inhaled drugs in adult asthma patients. It consists of two parts: the correct use of the inhalers; and compliance with the therapy, or how much the patient follows the therapy plan as prescribed. 2. investigate the effect of using the Kata® App on asthma symptoms and asthma control, as measured by the Asthma Control Test (ACT) questionnaire. In addition, asthma-related quality of life, lung function, and ease of use of the app will be assessed during the study. This multicenter study follows a randomized, controlled, parallel-group, adaptive two-stage design. The study includes two different groups: an intervention and a control group. At the beginning of the study, each patient is randomly assigned to one of these two groups. The total duration of the study is 13 weeks: 1 baseline week and 12 intervention weeks. During the baseline week, the intervention and control group both use the app with limited functionality. Kata records their inhalations but does not provide inhalation training or feedback. This is to first assess how well patients are able to use their inhaler(s) without receiving support. After the first week, the intervention group starts using the app with full functionality for 12 weeks, which means that the app provides them with inhalation training and personalized feedback. The control group continues to use the app with limited functionality for 12 weeks, that means that they continue to use the app to record their inhalations but do not receive any inhalation training or feedback. This study will compare the patients in the intervention and control group, to find out the effect of using the Kata® inhalation app on the number of errors patients make when using their inhaler, therapy compliance, and health-related outcomes (asthma control, quality of life, and lung function). |
VISIONHEALTH | 2023-12-20 |
| 231 | To Compare The Bronchoprotective Effects of The Test and Reference Metered Dose Inhalers (MDIs) Containing Albuterol Sulfate Using Methacholine Bronchoprovocation Challenge Testing in Stable Mild Asthma Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to demonstrate the pharmacodynamic bioequivalence of the test product to the reference product, using bronchoprovocation (methacholine challenge testing) in adult patients with stable mild asthma. |
SARAH SMILEY; | 2023-12-11 |
| 232 | Influencing Factors of The Diagnostic Accuracy of Novel Coronary Functional Evaluation Methods: A Cross-sectional Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, patients were retrospectively included, univariate and multivariate analysis of factors affecting their diagnosis inconsistencies was performed, and a new diagnostic model was constructed by logistic regression. |
PEKING UNIVERSITY THIRD HOSPITAL | 2023-12-01 |
| 233 | The Efficacy and Safety of Omalizumab in The Treatment of Moderate to Severe Allergic Asthma:A Retrospective Single-center Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Allergic asthma being the most widespread and easily identifiable phenotype, accounting for 60-80% of cases.Previous studies have reported that nearly 90% of patients with severe asthma were cases of allergic asthma, in which Immunoglobulin E (IgE) plays a critical role.Omalizumab was approved as an anti-IgE humanized monoclonal antibody for the treatment of patients with poorly controlled moderate-to-severe asthma, and was the first targeted drug used in the field of asthma treatment.The drug was launched in mainland China in August 2017.whereas,the clinical application experience, effects, … |
THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY | 2023-12-01 |
| 234 | A Randomized Trial Comparing The Role of Prednisolone, Itraconazole, or Their Combination in Patients with Acute Stage of Allergic Bronchopulmonary Aspergillosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators hypothesize that a combination of prednisolone and itraconazole would significantly reduce the exacerbation rate at one-year of patients with acute allergic bronchopulmonary aspergillosis (ABPA) compared to itraconazole or prednisolone monotherapy. In this study, 300 subjects aged ≥18 years with acute ABPA will be randomized to treatment with either prednisolone, itraconazole, or prednisolone plus itraconazole, all for four months each. After collecting baseline demographic, immunologic, and imaging data, … |
RITESH AGARWAL; | 2023-12-01 |
| 235 | Effects of Manual Diaphragmatic Release Technique Versus Chest Wall Expansion Exercises on Pulmonary Function, Chest Wall Expansion and Asthma Control in Patients With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effects of manual diaphragmatic release technique (MDRT) versus chest wall expansion exercises on pulmonary function, chest wall expansion and asthma control in patients with asthma. |
QURAT UL-AIN; | 2023-12-01 |
| 236 | Evaluation of Cardiac Biomarkers and The Left and Right Ventricular Systolic and Diastolic Function in Asthmatic Children in Assuit University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Severe acute asthma which is defined asthma that is uncontrolled despite maximal optimized therapy and treatment of contributory factors, or that worsens when high dose treatment … |
ASMAA KHALAF SABER; | 2023-12-01 |
| 237 | Assessment of Right Ventricular Function Among Children With Chronic Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Pediatric Chronic lung disease (CLD) is an abroad term that encompasses a heterogeneous group of different clinicopathological disorders that advance slowly over months or years. They can broadly be divided into two groups: those with a known cause and those without. Cystic fibrosis, broncho-pulmonary dysplasia or lung of prematurity, asthma, chronic gastro esophageal reflux/aspiration pneumonitis, and constrictive obliterative bronchiolitis, chronic infection, and hypersensitivity pneumonitis are all included in the first group. The second group is subdivided into primary pulmonary diseases (idiopathic interstitial pneumonia, persistent tachypnea of infancy associated with neuroendocrine cell hyperplasia, pulmonary lymphatic and vascular disorders, … |
ASSIUT UNIVERSITY | 2023-12-01 |
| 238 | Effects of Pulmonary Rehabilitation on Activities of Daily Living, Physical Activities of Daily Living and Other Clinical Outcomes in Children With Asthma: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Although the practice of physical activity is recommended for children with asthma, the scientific literature available so far has focused mainly on improving functional capacity and quality of life. However, the effects of pulmonary rehabilitation in this population, especially in improving the level of physical activity in daily living (PADL) and activities of daily living (ADLs) have not yet been investigated in depth. Therefore, the objective of this study is to verify the effects of pulmonary rehabilitation on PADL, ADL, and other clinical outcomes of children with asthma. For this, … |
KARINA FURLANETTO; | 2023-12-01 |
| 239 | The Effects of A 12-week Combined Exercise Intervention on The Gut Microbiome of Older Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There are trillions of microorganisms living alongside us in our guts. Recent research has shown that this community, known as the gut microbiome, has a big influence on our health and wellbeing. Imbalances in the composition of the gut microbial community has been linked to several diseases including COVID, mental ill health, and diabetes. When the composition of the gut microbiome changes towards a less healthy one (called dysbiosis) this will, in turn, affect our health in a negative way. The composition of our gut microbiome remains fairly stable during adulthood, however, as we move into older age, … |
CATARINA RAMOS; | 2023-12-01 |
| 240 | Comparison of The Effects of Yoga and Conventional Physiotherapy Programs on Fatigue, Pulmonary Functions and Exercise Capacity in Patients With Sarcoidosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sarcoidosis is a multisystem disease, characterized by the formation of immune granulomas with various clinical symptoms depending on the involved organs, which can involve many organs and systems associated with emotional and physical consequences that affect the quality of life, whose cause is unknown, but usually affects the respiratory system, and occurs mostly in young and middle-aged adults. Lung involvement, seen in 95% of patients, causes limitation of lung capacity and decrease in inspiratory muscle strength, which are important factors that lead to an increase in dyspnea and a decrease in walking distance. In addition to respiratory muscle weakness, … |
ŞEYDA YILDIZ; | 2023-11-30 |
| 241 | A 12-week Double-blind, Multicentre, Randomised, Active-controlled, 2-arm, Parallel-group Clinical Trial to Evaluate The Safety of CHF5993 PMDI 200/6/12.5 Μg HFA-152a, Compared to CHF5993 PMDI 200/6/12.5 Μg HFA-134a, in Subjects With Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The CLI-05993AB6-03 Study is an interventional study designed to investigate the safety and efficacy of a new low global warming potential propellant (HFA-152a) compared to the currently approved one (HFA-134a) in the medication (CHF5993) in patients with moderate to severe asthma |
DAVE SINGH; | 2023-11-27 |
| 242 | A 52-week, Randomised, Double Blind, Multicentre, 2-arm Parallel Group Trial Assessing Efficacy of CHF6001 (Total Daily Dose 3200μg) Dry Powder Inhaler (DPI) Add-on to Maintenance Medium or High Dose of Inhaled Corticosteroids in Combination With Long-acting ß2-agonists in Subjects With Uncontrolled Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and safety of CHF6001 (Tanimilast) as add-on to maintenance of inhaled corticosteroids in combination with Long-acting ß2-agonists in the target patient population. (TANGO) |
JOHANN CHRISTIAN VIRCHOW; | 2023-11-26 |
| 243 | Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: COMPARISON OF EFFICACY OF HYDROCORTISONE AND METHYLPREDNISOLONE IN ACUTE SEVERE ASTHMA In this study Investigator will compare the efficacy of hydrocortisone and methyl prednisolone in acute severe asthma that will lead to final result and beneficial effects that will help in early resoloution of symptoms and help in preventing recurrence |
INAYAT UR REHMAN; | 2023-11-26 |
| 244 | Evaluation of App-based Management of Children’s Asthma Based on Real World Data and Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-center randomized controlled trial of children with asthma. The objective of the study is to compare the App-based efficacy of China Children Asthma Action Plan (CCAAP) and written CCAAP used in management of children with asthma. The main questions are:1. Is the App-based CCAAP effective/feasible in management of children with asthma? 2. Is the App-based CCAAP better than written CCAAP in management of children with asthma? |
KUNLING SHEN; | 2023-11-25 |
| 245 | Comparison of The Effects of Perioperative Intravenous Infusions of Esmolol and Lidocaine on The Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery:A Randomized, Non-inferiority Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Functional endoscopic sinus surgery (FESS) is one of the effective modalities for the treatment of chronic sinusitis, with the advantages of deep approach, light trauma, and less pain. However, because the operation area involves the nose, eyes and cranial region, the surrounding tissue structure is complex and rich in blood vessels and nerves, and the use of epinephrine, intraoperative tissue damage, nerve stimulation, and postoperative inflammation, edema, hemorrhage, and nasal cavity stuffing can cause patients’ stress reaction and postoperative pain, resulting in patients’ anxiety, depression, and sleep disorders, which can reduce the quality of early postoperative recovery, … |
CHENGLAN XIE; | 2023-11-21 |
| 246 | A Trial in Participants With Chronic Obstructive Pulmonary Disease (COPD) to Evaluate The Impact of Vapendavir on The Development of Lower Respiratory Tract Symptoms Following Rhinovirus Challenge PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vapendavir (VPV) is a drug being developed to treat human rhinovirus (RV) infection, one virus responsible for the common cold. Vapendavir prevents the virus from entering cells and making more infectious copies of itself. A study is being planned to investigate VPV in patients with chronic obstructive pulmonary disease (COPD, a lung disease making it difficult to breathe) who develop a rhinoviral infection; however, VPV has not been approved for use in treating any indication (disease) by the FDA or any other global regulatory agency. Therefore, VPV is considered investigational, … |
ONN MIN KON; | 2023-11-20 |
| 247 | Spectrum Of Airway Involvement In Inflammatory Bowel Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To estimate prevalence of subclinical airway injuries among IBD patients. To investigate relationship between activity of IBD and airways |
HEND MOHAMED SAYED MOHAMED; | 2023-11-20 |
| 248 | A Phase 2a Randomised, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of AZD4604 Twice Daily for Twelve Weeks in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2a, multicentre, randomised, placebo-controlled, double-blind, parallel-group study to evaluate the efficacy, safety and PK of AZD4604 administered BID using a dry-powder inhaler at one dose level over a 12-week Treatment period in adult participants with uncontrolled moderate-to-severe asthma. |
ASTRAZENECA | 2023-11-16 |
| 249 | Detection of Pre-Diabetes in Overweight and Obese Children and Adolescents in Assiut Governorate PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Descriptive cross section study To detect prediabetes in overweight and obese children and adolescents in Assiut Governorate and to find out the possible risk factors. |
MAHMOUD BAKR GABER; | 2023-11-15 |
| 250 | Effects of Aminophylline Bolus on Eleveld and Schnider TCI (Target Controlled Infusion) Concentrations at Start and End of Burst Suppression Occurence and on BIS (Bispectral Index) During The Induction Phase of Total Intravenous Anaesthesia With TCI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aminophylline is an intravenous drug commonly utilized for asthma. However, some preclinical studies and few case reports and case series have described its effects in lightining the anesthestic plan during Propofol anaesthesia with an intravenous bolus of 4 mg/kg. Authors aimed to compare its effect during accidental episodes of Burst Suppression during the induction phase of total Intravenous Anaesthesia with Target Controlled Infusion (TIVA-TCI) routinely utilized for general anaesthesia in our hospital. |
FEDERICO LINASSI; | 2023-11-12 |
| 251 | Impacts of Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery: A Prospective Randomized Double Blinded Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the usefulness of adding aminophylline to dexmedetomidine intravenous infusion intraoperatively on oxygenation and lung mechanics in chronic obstructive pulmonary disease (COPD) morbidly obese patients undergoing bariatric surgery. |
SOLIMAN RAMADAN AHMED NASER; | 2023-11-11 |
| 252 | Methacholine Challenge Testing: Comparison of FEV1 and IOS Parameters in Adult Asthma Patients PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A classic methacholine challenge test is considered positive when forced expiratory volumen after one second (FEV1) decrease 20%. Impulse oscillometry (IOS) measures airway resistance and reactance, and seems more sensitive to changes in small airways. In adult asthma patients, we compare methacholine challenge test using both FEV1 and IOS. |
THOMAS RINGBÆK; | 2023-11-01 |
| 253 | Knowledge and Usage of Lactation Using Education and Advice From Support Network (KULEA-NET) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: KULEA-NET is a mHealth intervention that will improve knowledge, self-efficacy, and intentions related to exclusive breastfeeding (EBF). These factors have been demonstrated to have a positive influence on breastfeeding (BF) initiation and duration among African American/Black (AA/B) mothers. In the long term, KULEA-NET has great potential to achieve increased BF initiation and EBF rates among AA/B mothers and as a result, improved maternal and infant health outcomes. |
TONY MA; | 2023-11-01 |
| 254 | Assessment of Bronchial Asthma Among Patients Attending Sohag University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a significant public health threat, affecting more than 300 million individuals globally. Asthma is classified as a non-communicable disease and leads to reduced quality of life, poor physical functioning and reduced emotional well-being. The impact of this disease can be widespread and extends beyond the person living with the disease, affecting the lives of their family members, carers, communities and the health care system (1). Asthma is a variable chronic respiratory condition. It is characterized by symptoms of wheeze, cough, chest tightness, dyspnea and backed by variable airflow limitation, … |
DOHA MOHAMED ISMAIL; | 2023-11-01 |
| 255 | Patient and Prescriber Perspective on Climate Impact of Inhalers in The Treatment of Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The effects of climate change on population health have considerably increased as the planet warms and is thus subjected to more heat waves, extreme weather events and food insecurity. Paradoxically, healthcare systems are major contributors to carbon emissions. Within the field of respirology, … |
NICOLE EZER; | 2023-11-01 |
| 256 | Effects of Aminophylline Bolus on Eleveld and Schnider TCI (Target Controlled Infusion) Concentrations at Return of Responsiveness and on BIS (Bispectral Index) After Total Intravenous Anaesthesia With TCI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aminophylline is an intravenous drug commonly utilized for asthma. Hovewer, some preclinical studies and few case reports and case series have described its utility in decrease the timing of return of consciousness after Propofol anaesthesia with an intravenous bolus of 4 mg/kg. We aimed to compare its effect during a total Intravenous Anasethesia with Target Controlled Infusion (TIVA-TCI) routinely utilized for general anaesthesia in our hospital. |
FEDERICO LINASSI; | 2023-11-01 |
| 257 | Physiological Study of Prone Position in Acute Respiratory Failure Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: ARDS is an acutely induced respiratory failure characterized by the appearance of bilateral alveolar opacities on imaging and hypoxemia Etiologies are divided into two classes: pulmonary, including all infectious pathologies, aspiration pneumonia, and drowning, and extra-pulmonary, induced by sepsis or acute pancreatitis. The mortality rate of ARDS remains high in unselected patient populations Among strategies that have proven beneficial in terms of patient outcome, … |
JEAN DAMIEN RICARD; | 2023-11-01 |
| 258 | The Effect of Slow Breathing Exercise Applied to Patients After Primary Percutaneous Coronary Intervention on Pulse, Blood Pressure and Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was designed as a randomized controlled experimental type in order to determine the effect of slow breathing exercise applied after the procedure on heart rate, blood pressure and quality of life in patients who underwent Primary Percutaneous Coronary Intervention (PCI) I after the diagnosis of ST Elevation Myocardial Infarction (STEMI). Patients who underwent primary PCI due to STEMI in a Training and Research Hospital in Istanbul will constitute the study population. A sample will be formed with a total of 80 patients, 40 experimental and 40 control groups, … |
MELIKE ÇELIK; | 2023-10-23 |
| 259 | A Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose Ranging Study to Assess The Efficacy, Safety, and Tolerability of Subcutaneous Lunsekimig in Adult Participants With Moderate-to-severe Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2b, global, multicenter, randomized, double-blind, placebo-controlled, parallel group, dose ranging study to assess the efficacy, safety, and tolerability of add-on therapy with SC lunsekimig in adult participants aged 18 to 80 years, (inclusive) with moderate-to-severe asthma. |
SANOFI | 2023-10-16 |
| 260 | The Rainbow Study – A Randomized Controlled Trial to Evaluate The Effect of Personalized Feedback on Symptom Perception in Asthmatic Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a common childhood disease that is characterized by chronic airway inflammation and episodic expiratory airflow obstruction. Asthma symptoms can impair participation in play and sports and have a negative impact on quality of life. It can be challenging for children to adequately feel and report their symptoms. Some children experience more symptoms than expected based on lung function during these symptoms, whereas others experience less symptoms than expected. This is also called ‘symptom perception’. A tool was developed to visualize symptoms, … |
VERA HENGEVELD; | 2023-10-16 |
| 261 | Early Detection of The Effectiveness of Treatment With Biologicals in Patients With Severe Asthma Using Fluctuation Analysis of Biomarkers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare the fluctuation patterns of biomarkers (Spirometry, FeNO, IOS) of responders and non-responders in asthma patients who will start treatment with a biologic. The main question it aims to answer is: Can fluctuation patterns of parameters for spirometry, FeNO and IOS before and after starting treatment with biologics in patients with severe asthma be used to predict a successful intervention. Participants will measure Spirometry, FeNO and IOS twice a day at home for 2 or 3 months starting one month before starting treatment with a biological. |
ELS J.M. WEERSINK; | 2023-10-15 |
| 262 | A Pilot Study of Efficacy and Safety of A Microbiome Immunity Formula (SIM05) in Adults with Atopic Eczema PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Atopic eczema causes significant disease burdens worldwide. Some studies reported gastrointestinal symptoms in eczema patients which could be related to gut microbiota change. A unique gastrointestinal microflora pattern has also been observed in atopic dermatitis patients when compared with healthy controls. To date, … |
SIEW CHIEN NG; | 2023-10-10 |
| 263 | The Bronchiolitis in Hospitalized Infants (BroncHI) Study: A Feasibility Trial Aimed to Identify and Treat Hospitalized Infants With Bronchiolitis Most at Risk for Recurrent Wheezing and Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine whether it is possible to identify, enroll, and deliver the study intervention (the corticosteroid dexamethasone) in hospitalized infants with bronchiolitis. Participants in this study will be given two doses of dexamethasone within 72 hours of enrollment, followed by 30 days of safety monitoring. Results of this feasibility pilot study may be used to inform the design of a future randomized controlled trial, whose results in turn could induce a paradigm shift in acute management of bronchiolitis. |
IDEA STATES PEDIATRIC CLINICAL TRIALS NETWORK | 2023-10-09 |
| 264 | A Pharmacist-Led Intervention on Medication Adherence and Inhaler Usage on Clinical Outcomes Among Patients With Asthma and Chronic Obstructive Pulmonary Disease in Ibadan, Nigeria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the impact of a pharmacist-led intervention programme on medication adherence and use of inhaler devices on clinical outcomes of patients with asthma and COPD attending a tertiary health facility in Nigeria. |
UYIOSE FORTRESS UFUAH; | 2023-10-04 |
| 265 | Pattern and Outcome of Respiratory Diseases in Patients Admitted in The Chest Department at Assiut University Hospital PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine the pattern and outcome of respiratory diseases in adults patients admitted to the Department of Chest Diseases at Assiut University Hospital. |
FATMA HAMDAN ZAKI ADEEL; | 2023-10-01 |
| 266 | A Multi-national Phase IIIb, Double-blind, Placebo-controlled Trial to Determine The Safety and Efficacy of STALORAL® Birch 300 IR in Children and Adolescents 5 to 17 Yo With Birch Pollen-induced Allergic Rhinoconjunctivitis W/o Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Allergic rhinoconjunctivitis due to birch pollen is a seasonal problem which manifests as a combination of nasal symptoms (such as congestion, runny nose, sneezing, itching of the nose) and ocular symptoms (such as red, itchy and watery eyes). For several birch-allergic patients, allergic rhinoconjunctivitis occurs with an oral allergy syndrome. The purpose of this study is to demonstrate the safety and efficacy of the study drug (STALORAL Birch 300 IR) in children and adolescents with birch pollen-induced allergic rhinoconjunctivitis, with or without asthma, … |
OLIVER PFARR; | 2023-10-01 |
| 267 | Evaluation of Micronutrient Levels and Micronutrient Supplement Use in Patients Hospitalized in The Pediatric Palliative Care Service PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to determine the micronutrient levels and frequency of use of micronutrient supplements in patients in the Pediatric Palliative Care Clinic. The main questions it aims to answer are: – What is the frequency of micronutrient deficiencies in pediatric palliative care patients? – What is the frequency of micronutrient supplement use in pediatric palliative care patients? |
DERŞAN ONUR; | 2023-10-01 |
| 268 | Assessment of Feasibility and Effectiveness of Remote Asthma Management Via An Integrated Artificial Intelligence-assisted Clinical Decision Support System With Mobile Device Compared With Usual Asthma Care in Pediatric Participants With Asthma Aged 6-17 Years: A Parallel Group, Non-blinded, Dual-site, 2-arm, Pragmatic Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to look at whether clinicians and their patients with asthma can satisfactorily perform remote asthma management at home (not visiting clinic) by using an artificial intelligence tool called Asthma-Guidance and Prediction System combined with a home monitoring device called AsthmaTuner. |
YOUNG JUHN; | 2023-10-01 |
| 269 | Does Cerebral Substrate Switching Underlie The Beneficial Brain Adaptations of Fasting and Exercise? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The brain is constantly active and energetically expensive, making up a quarter of the body’s energy budget despite occupying only 2% of its mass. To fuel this incessant activity, the brain relies on glucose, which accommodates 99% of its metabolic needs. In most cases, glucose is the ideal fuel since it is in constant surplus owing to 24-hr access to sugar-rich food. However, the brain is metabolically flexible and capable of metabolizing alternative fuels when glucose is scarce, or, decreasing rapidly. For example, during fasting when glucose stores are dwindling, … |
PHIL AINSLIE; | 2023-10-01 |
| 270 | Dupilumab Efficacy on Bronchial Inflammation, Small Airways Disfunction and Mucous Secretion in The Real Life Severe Asthma Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Unicentric prospective real life study designed to analyse the efficacy of Dupilumab to reduce bronchial inflammation of asthma measured by inflammatory cell counts obtained in induced sputum and other related characteristics (small airway dysfunction and mucin production) in uncontrolled severe asthma patients in the real life setting without control group |
FUNDACIÓ INSTITUT DE RECERCA DE L’HOSPITAL DE LA SANTA CREU I SANT PAU | 2023-10-01 |
| 271 | Evaluation of The Concept Can Do Versus Do Do in Patients With Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Breast cancer occurs as a result of uncontrolled proliferation of cells in the breast tissue. Breast cancer is the most common type of cancer among women worldwide and is an important problem that threatens women’s lives. The incidence rate has reached approximately 16 Breast cancer treatment consists of local and systemic therapies. While local treatments include surgery and radiotherapy, systemic treatments, which are administered in two different ways, namely adjuvant and neoadjuvant systemic treatments, consist of chemotherapy, hormone therapy and targeted biological therapies. Although the treatment options for breast cancer are increasing day by day, … |
EBRU CALIK KUTUKCU; | 2023-09-30 |
| 272 | Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial of Inspiratory Training (IT). The primary outcome is to describe the contributions of inspiratory muscle dysfunction (IMD) and Small Airway Dysfunction (SAD) to obesity-related versus non-obesity-related asthma. The study will involve training (IT) for 8 weeks at three intensity levels (SHAM, … |
JASON LANG; | 2023-09-30 |
| 273 | Effectiveness of Tezepelumab on Asthma Control and Cough: A Prospective, Multi-center, Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study assesses the impact of tezepelumab treatment not only on asthma control but also on cough specific Health-Related Quality of Life (HRQoL). Asthma control can be evaluated using Asthma Control Questionnaire (ACQ). Cough symptom which is one of the symptoms related airway hyperresponsiveness can be assessed via the relevant questionnaire, Leicester Cough Questionnaire (LCQ). There is moderate negative correlation between ACQ and LCQ . Improvements in both asthma control and cough symptom by tezepelumab would clarify effectiveness of Tezepelumab in real-world. Though Tezepelumab is recently approved in Japan, there is no real-world evidence on tezepelumab, … |
ASTRAZENECA | 2023-09-27 |
| 274 | The Impact of Dietary Supplementation With Lactobacillus Helveticus and Bifidobacterium Longum on The Functioning of The Brain-gut Axis, in The Context of Mental Health, Eating Patterns and Nutritional Status of Young Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Research on probiotic supplementation in the prevention and treatment of depressive and anxiety disorders and stress coping skills has been conducted for many years. This research project was designed to investigate the effects of both, probiotic supplementation and diet quality on a wide range of psychological, microbiological, biochemical, and clinical outcomes. The aim of the study was to assess the effects of targeted supplementation with Lactobacillus helveticus and Bifidobacterium longum on gut microbiota composition and quality, mental health, perceived stress intensity, psychosomatic response, … |
MAGDALENA CZLAPKA-MATYASIK; | 2023-09-26 |
| 275 | The Impact of Simulated Forest Immersion Therapy on Pain and Anxiety in Patients Axial Spondyloarthritis (axSpA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to learn about the ease of using a humidified fragrant citrus forest oil, along with a virtual simulation of a forest environment (i.e., with sights and sounds of nature using a personal tablet Surface Pro 3 with headphones, to learn more about how these two aspects of the simulated forest immersion therapy (SFIT) may improve pain, anxiety, blood-pressure, and heart rate related to Axial Spondyloarthritis. The investigators hope to learn how well SFIT may impact pain levels, feelings of calm, as well as blood- pressure and heart rate, … |
AMY ROSS; | 2023-09-21 |
| 276 | Dexmedetomidine Versus Ketamine Versus Magnesium Sulfate for The Prevention of Emergence Agitation Following Sevoflurane Induced Anesthesia in Cardiac Catheterization in Pediatrics : A Prospective, Double-blinded, Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Emergence agitation (EA) is a post-operative behavioral disturbance was first reported in early 1960s. EA is a term used to describe non purposeful restlessness and agitation, thrashing, crying or moaning, disorientation and incoherence during early stage of recovering from general anesthesia in children, especially those receiving sevoflurane. Generally, the incidence of EA following sevoflurane anesthesia varies from 10% to 66% and is more common in pre-school children. EA is generally short lived without obvious aftereffect. However, it still accompanies with risk of self-injury, and requires extra nursing care, … |
AMANY HASSAN SALEH; | 2023-09-20 |
| 277 | Clinical and Medico-economic Study to Validate The Performance of A Digital and Personalized Solution (HEPHAÏ) to Support The Use of Inhaled Treatments for Asthma and COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In a context where the use of inhalation devices for respiratory medications is associated with a high frequency of critical errors, our primary hypothesis is that the use of the HEPHAÏ solution reduces this frequency compared to standard care. The objective of this clinical study is to evaluate the performance of the HEPHAÏ solution as a tool for improving the administration of inhaled treatments in patients undergoing pulmonary care for asthma and/or COPD, … |
CAPUCINE CAPUCINE.MORELOT@APHP.FR; | 2023-09-19 |
| 278 | Validity and Reliability of Fitnessgram and Pediatric Functional Reach Tests Applied With Face-to-Face and Tele-Assessment Methods in Children With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a chronic inflammatory disease of the airways. Childhood asthma is quite common. The airway responds unusually to triggers. There are episodes of recurrent wheezing, shortness of breath, chest tightness, and/or coughing that may change in intensity over time. Sudden contraction of airway smooth muscle may be reversible. It is characterized by common but also variable airflow obstruction. With the development of today’s technology age, … |
ŞEYMA NUR ÖNAL; | 2023-09-15 |
| 279 | Characterization of Natural Killer Cells in Severe Asthma Patients in Comparison With Control Subjects: Identification of Biomarkers, Response During Virus-induced Exacerbations, and Interaction With Bronchial Epithelial Cells PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a common chronic bronchial disease affecting 300 million people worldwide. The disease can be severe when it is not managed properly or when it is not controlled by treatments. Asthma is characterized by bronchial inflammation, bronchial hyperreactivity and tissue remodeling. Symptoms include episodes of coughing, dyspnoea and wheezing in relation with bronchial obstruction. The evolution is marked by the occurrence of exacerbations (increase of symptoms), most often triggered by viral infections, mostly due to rhinoviruses. The treatment of asthma is based on inhaled corticosteroid therapy sometimes combined with other treatments that help control the majority of asthma. However, … |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE FRANCE | 2023-09-07 |
| 280 | A Long-term Extension Study to Evaluate The Long-term Safety, Tolerability, and Efficacy of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study of amlitelimab for the treatment of participants with moderate-to-severe asthma. The study will have a double-blind treatment period until Week 24 for each participant and an open-label treatment period where each participant will receive open-label amlitelimab from Week 24 onwards. The purpose of this study is to evaluate long-term safety, tolerability, … |
SANOFI | 2023-09-05 |
| 281 | Optimising Pharmacist-led Medication Reviews in Primary Care (OPen): A Qualitative Study to Co-design and Test An Optimised Medication Review for Patients With Long-term Conditions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An increasing number of people are diagnosed with long-term conditions and are prescribed medicines to manage these conditions. Medication reviews (MRs) are used to optimise medicines, improve health outcomes, and decrease medicines related problems. Although medication reviews are widely used in health care settings, there has not been a dramatic change in the the rate at which patients experience poor medicines outcomes such as adverse drug reactions and hospitalisations. This research wants to understand how medication reviews by pharmacists are delivered in GP surgeries and community pharmacies. The research team plans to test a co-designed document, … |
UNIVERSITY OF EAST ANGLIA | 2023-09-04 |
| 282 | Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are: * the proportion of MTB infection among school contacts of ATB patients * risk factors related to tuberculosis (TB) infection * health economic evaluation of screening strategy |
WEN-HONG ZHANG; | 2023-09-01 |
| 283 | A Retrospective Cohort Study on The Risk Factors and Prognosis of Asthma With Frequent Acute Attacks Phenotype PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Identify the risk factors for frequent acute exacerbations of asthma: establish a retrospective study, classify patients into frequent acute exacerbation group and non-frequent acute exacerbation group based on the number of acute exacerbations, analyze the characteristics of the two groups, provide clinical, pathological, and comorbidity features of the frequent acute exacerbation subtype of asthma, determine the risk factors associated with frequent acute exacerbations, and establish a disease prediction model for frequent acute exacerbations of asthma. 2. Observe the prognosis and treatment outcome of patients with frequent acute exacerbations of asthma, … |
LIANG DONG; | 2023-09-01 |
| 284 | Etiology Analysis of Chronic Cough After COVID-19 Infection and Research on The Efficacy of ICS or ICS/LABA PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study collected 600 patients, evaluated whether patients had airway hyperreactivity, airway inflammation, specific types and allergic reactions, comprehensively analyzed and classified the causes of chronic cough in patients, and evaluated and compared the improvement of cough symptoms and quality of life after ICS or ICS/LABA treatment. |
JUAN JIANG; | 2023-09-01 |
| 285 | Evaluation Of Orofacial Myofunctional Disorders Among A Group Of Children With Bronchial Asthma: A Cross-Sectional (Observational) Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate orofacial myofunctional disorders among a group of children with bronchial asthma. |
YARA MAMDOUH KHALIFA AHMED; | 2023-09-01 |
| 286 | Effects of Deep Breathing Exercise on Pulmonary Function, Perceived Stress and Physical Fitness Among Healthy Smokers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Effects of deep breathing exercise on pulmonary function, perceived stress and physical fitness among healthy smokers. |
MALIK MUHAMMAD ALI AWAN; | 2023-09-01 |
| 287 | A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Investigate The Efficacy and Safety of NS-229 in The Treatment of Eosinophilic Granulomatosis With Polyangiitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will enroll male and female subjects who are 18 years of age or older with Eosinophilic Granulomatosis With Polyangiitis. |
NS PHARMA | 2023-09-01 |
| 288 | A Culturally Tailored Scalable Asthma Intervention for Hispanic Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a two-arm, parallel design, randomized, controlled pilot trial comparing access to Asma Guardián, a culturally tailored multi-component app-based asthma intervention for Hispanic/Latinx school age children with asthma, to usual care. |
ELIZABETH MATSUI; | 2023-09-01 |
| 289 | Comparative Effects of Active Cycle Breathing Technique and Bubble Positive Expiratory Pressure Device in Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study gap is that in previous studies the effects of bubble-PEP in different diseases have been studied but it’s never been studied in asthmatic patients, so the reason behind this study is to see effects of bubble-PEP in Asthmatic Patients. |
ARNAB ALTAF; | 2023-09-01 |
| 290 | Non-Eosinophilic Biological Effects of Interleukin 5 (IL-5) – Role of IL-5 in Suppressing Anti-Viral Immunity in Bronchial Epithelial Cells and Dendritic Cells in Asthma Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the role of IL-5 in suppressing anti-viral immune responses in bronchial epithelial cells (BECs) and in peripheral blood mononuclear cells (PBMCs) from 5 people with asthma. |
IMPERIAL COLLEGE LONDON | 2023-09-01 |
| 291 | A Randomized, Double-Blind, Multicenter, Active-Controlled, Parallel-Group Study to Evaluate The Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Fixed-Dose Combination on Severe Asthma Exacerbations in Patients With Asthma PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to assess the efficacy of high dose and low dose fluticasone propionate (Fp)/albuterol sulfate (ABS) integrated electronic module multidose dry powder inhaler (eMDPI) compared to ABS eMDPI in decreasing severe clinical asthma exacerbation (CAEs). Secondary Objectives: To evaluate the efficacy of Fp/ABS compared to ABS and the effect on systemic corticosteroid (SCS) exposure To evaluate the safety and tolerability of Fp/A BS The duration for each participant will be a minimum of 28 weeks including 2 weeks of screening, … |
TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D | 2023-08-30 |
| 292 | Implementation of Behavioral and Sleep Hygiene Education With Mindfulness Intervention to Improve Sleep Regularity in Adolescents; Is There A Relationship With Anxiety, Depression or Chronotype PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Sleep plays a fundamental role in both mental- and physical-health, with good sleep health including adequate duration and quality, appropriate timing, regularity, and absence of sleep disorders. The purpose of this study is to evaluate sleep in adolescent and if brief behavioral and sleep hygiene education with mindfulness intervention improves, sleep timing, sleep duration, sleep quality, anxiety- and depression symptoms. During adolescence extensive physiological changes happen that make it easier for adolescents to stay up later, that may increase the time it may take them to fall-asleep and developing insomnia symptoms. At the same time psychosocial changes happen, … |
SOLVEIG MAGNUSDOTTIR; | 2023-08-28 |
| 293 | EFFECT OF PRANAYAMA YOGA ON SYMPTOMS, FATIGUE AND RESPIRATORY PARAMETERS IN INDIVIDUALS WITH COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study In this study, pranayama yoga practices are the sub-dimensions of respiratory parameters, symptom and disease affection level, psychosocial adjustment and psychosocial adjustment in individuals with COPD. It was planned in a randomized controlled manner to examine the effects of healthcare compliance, professional environment, family environment, sexual relations, extended family relationships, … |
YEDITEPE UNIVERSITY | 2023-08-25 |
| 294 | A Multicentre, Randomised, Double-Blind, Parallel-Group Placebo-Controlled, Phase 3, Efficacy and Safety Study of Tezepelumab in 5 to < 12 Year Old Children With Severe Uncontrolled Asthma (HORIZON) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the efficacy and safety of tezepelumab in pediatric participants with severe uncontrolled asthma on medium to high-dose inhaled corticosteroids (ICS) and at least one additional asthma controller medication with or without oral corticosteroids. |
ASTRAZENECA | 2023-08-24 |
| 295 | Sonu Real-World Use Clinical Study to Treat Moderate to Severe Nasal Congestion PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Real world utilization of Acoustic Resonance Therapy for symptoms of Nasal Congestion |
JACOB JOHNSON; | 2023-08-08 |
| 296 | A Single-blind (Patient-blind), Randomized, Placebo-controlled, Intranasal Administration Study on Mechanisms and Potential Efficacy of AD17002 in Subjects With Poorly Controlled, Moderate to Severe Eosinophilic Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate patients who have poorly controlled, moderate to severe eosinophilic asthma. The main questions it aims to answer are Could the LTh(αK) intranasal treatment improve the clinical condition of these patients? Could patients self-administrate LTh(αK) via the intranasal route? Is the LTh(αK) at multiple doses safe for asthmatic patients? Participants will be asked to self-administrate two doses per week for a total of 6 weeks and a diary on the usage of LTh(αK), adverse event, and reliever medication used will be recorded. |
ADVAGENE BIOPHARMA | 2023-08-07 |
| 297 | A Prescreening Study to Diagnose Allergic Bronchopulmonary Aspergillosis in Selected Patients With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This prescreening study is being conducted to diagnose ABPA in selected patients with asthma and to increase the potential number of eligible participants for the ongoing Study 601-0018 of PUR1900 in subjects with ABPA. See: NCT05667662. Additionally, this prescreening study may provide information that could assist the conduct of future studies conducted by Pulmatrix. |
COMMUNITY PHARMACOLOGY SERVICES | 2023-08-01 |
| 298 | Phenotypic and Functional Characterization of Neutrophils and Eosinophils in Severe Asthma Treated With Biotherapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Neutrophils and eosinophils can have different functions. Depending on their environment, they can be more or less active, with more or less inflammatory activity. Biotherapies can reduce the number of inflammatory cells in the blood and bronchi. However, it is not known whether they have the ability to modify the functions of the remaining cells. The aim of this study is to better understand the functioning of eosinophilic and neutrophil polynuclear drugs involved in the response to biotherapies in severe asthma. The hypothesis is that biotherapies modify the inflammatory functions of polynuclear cells, … |
CAMILLE TAILLÉ; | 2023-08-01 |
| 299 | Asthma and Technology in Emerging African American Adults (The ATHENA Project) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the ATHENA Project is to test a mobile health intervention to help African American young adults better manage their asthma. The program has four components: 1) a web-based, mobile asthma program delivered to participants’ mobile device, 2) meetings with an asthma nurse via video conference, 3) text messaging, and 4) physical activity tracking. Participants will be randomly assigned to one or more of these components to better meet the needs of young adults with asthma. |
ALAN BAPTIST; | 2023-08-01 |
| 300 | Exploring Gas Transfer and The Utility of Dynamic Chest Radiography in Long Covid Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to identify if breathless patients with Long COVID have reduced transfer factor on pulmonary function testing and if the degree of transfer factor reduction is correlated with the symptom severity and physiological ability to exercise. We will also investigate whether a new type of X-ray called a dynamic chest X-ray can identify perfusion abnormalities and whether these correlate with differences in diffusion capacity measured on a pulmonary function test. |
LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST | 2023-08-01 |
| 301 | A Case-Control Study on The Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is; To Assess the association between periodontal health and Matrix metalloproteinase-8 (MMP-8) level in Gingival Crevicular Fluid (GCF) in post COVID-19 patients. |
RANDA NIDAL ALZOUBI; | 2023-08-01 |
| 302 | Comparison of Exercise Capacity, Physical Activity Level and Quality of Life of Children With Primary Immunodeficiency With Healthy Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare the maximal exercise capacity, functional exercise capacity, respiratory functions, physical activity level, quality of life, respiratory muscle strength and endurance, peripheral muscle strength, muscle oxygenation and dyspnea in children with primary immunodeficiency (PID) and healthy individuals. The study was designed as a cross-sectional study on 26 patients diagnosed with primary immunodeficiency and 26 age- and sex-matched healthy individuals. Differences between both groups will be evaluated statistically. The results of this study aim to reveal how primary immunodeficiency patients are affected by factors such as respiratory functions, physical activity level and quality of life |
MERAL BOŞNAK GÜÇLÜ; | 2023-08-01 |
| 303 | Effect of Senobi Breathing Exercise Versus Buteyko Breathing Technique on The Functional Performance Among Chronic Obstructive Pulmonary Disease Patient PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Effect of Senobi breathing exercise versus Buteyko breathing technique on functional performance among chronic obstructive pulmonary patient. |
SUMERA ABDULHAMEED; | 2023-07-20 |
| 304 | A Randomized Controlled Trial Comparing Diagnostic Performance of Primary Care Clinicians in The Interpretation of SPIROmetry With or Without Artificial Intelligence Decision Support Software PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate whether an artificial intelligence decision support software (ArtiQ.Spiro) improves the diagnostic accuracy of spirometry interpreted by primary care clinicians, as measured by Clinician Diagnostic Accuracy (vs Reference Standard). |
WILL MAN; | 2023-07-15 |
| 305 | Effects of Core Stability Combined With Diaphragmatic Strengthening Exercises Among Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a quasi intervention study evaluating the effects of core stabilization exercises and diaphragmatic strengthening on thoracic kyphosis angle, diaphragmatic excursion, chest expansion, lung functioning (FEV1/FVC ratio) and quality of life, in individuals with mild intermittent or mild persistent asthma. |
FOUNDATION UNIVERSITY ISLAMABAD | 2023-07-15 |
| 306 | Examining The Effect of Exercise Training on LncRNA MALAT1 Expression in Asthma Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in asthma. The main questions it aims to answer are: * Does respiratory muscle strengthening exercise added to respiratory rehabilitation in asthmatic patients have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, … |
FULYA SENEM KARAAHMETOGLU; | 2023-07-13 |
| 307 | A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being conducted to evaluate the effect of 3 dosing regimens of povorcitinib on pulmonary function |
INCYTE | 2023-07-11 |
| 308 | Analysis of Volatile Organic Compounds in Expired Air in Healthy Volunteers: Comparison of Three Mass Spectrometry Techniques for The Characterization of Volatolome in Clinical Studies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A major obstacle in precision medicine is the unavailability of biomarkers that are easy to access, non-invasive, measurable with high-performance techniques, fast, easy to use, reproducible, inexpensive and easily deployable on a large scale. The analysis of exhaled air (volatolomics) is an omics approach devoted to the analysis of volatile organic compounds (VOCs) eliminated by the pulmonary route with real-time detection, at the patient’s bedside. The reference technology for the analysis of VOCs is mass spectrometry (MS). Several types of mass spectrometers can be used, and, in the absence of a consensual and standardized method, … |
HOPITAL FOCH | 2023-07-08 |
| 309 | A Prospective, Blinded, Cross-Over Trial of The Exposure-Response Relationship of Terbutaline Sulfate in Adults With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aim in Part 1 is to compare the pharmacokinetic (PK)/pharmacodynamics (PD) relationship in intravenous (IV) versus subcutaneous (SQ) terbutaline sulfate to identify the optimal IV dosing range for use in Part 2. The overall aim in Part 2 is to evaluate the optimal IV dosing of terbutaline sulfate based on PD response and safety data. |
KANECIA OBIE ZIMMERMAN; | 2023-07-07 |
| 310 | The BASA Study: Breath Analysis for Severe Asthma Patients. A New, Non-invasive Approach for The Monitoring of Inflammation in Severe Asthma Patients on Biologics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the fluctuations of exhaled breath markers in patients with severe asthma on biologics. In the study, severe asthma patients will be followed up to 16 weeks monitoring lung function and inflammation through non-invasive technologies such as exhaled breath analysis (FeNO, GC-MS and EBC). A control group will be followed up to two weeks with the overall objective to indentify and evaluate the modifcations of markers of inflammation in patient under biologic treatment. |
STEFANIA PRINCIPE; | 2023-07-04 |
| 311 | Effectiveness of A Rehabilitation Nursing Consultation for People With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction Asthma is a chronic inflammatory disease of the respiratory airways and is considered a Public Health problem, which lacks a personalized multidisciplinary intervention, to allow the user to develop mastery in the self-management of his disease. The project intends to answer the question: What methods could be used to enhance the use of asthma controller therapy? Methods Randomized and controlled clinical trial. The sample consists of users with asthma at Family Health Units in the municipality of Oliveira de Azeméis. There will be an experimental group that will undergo structured rehabilitation nursing consultations, … |
ANDREIA PATRÍCIA DE OLIVEIRA SANTOS; | 2023-07-03 |
| 312 | A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose (SAD) Study to Evaluate The Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, AndImmunogenicity of RC1416 Injection Via Subcutaneous Administration in Healthy Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase I study to evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of RC1416 injection via Subcutaneous Administration in Healthy Adult Volunteers. |
LI J TONG; | 2023-07-03 |
| 313 | Video Developed for Children With Familial Mediterranean Fever The Effect of Game on Disease Management and Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was planned to be carried out as a pretest-posttest control group design in experimental type and randomized groups in order to determine the effect of educating children aged 8-14 with a diagnosis of Familial Mediterranean Fever through a mobile game application and training booklet on their disease knowledge, disease self-efficacy, symptom management and quality of life. H0: Informing children with Familial Mediterranean Fever through mobile games and educational booklets has no effect on the child’s knowledge of the disease, disease self-efficacy, … |
GAMZE KAS ALAY; | 2023-07-01 |
| 314 | The Duke-Reinvestment Partners Community Collaborative (DRC)- Healthy Homes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this open-label, single arm home intervention feasibility study is to improve quality of life for children ages 4-16 years with asthma. The main questions it aims to answer are: – How can Home-Based Environmental Interventions (HEI) improve home air-quality problems in the home? – How can HEI improve asthma outcomes in children? Participants will be receiving HEI and completing asthma surveys. |
JASON LANG; | 2023-07-01 |
| 315 | Non-randomised Feasibility Study Testing A Primary Care Intervention to Promote Engagement in An Online Health Community (OHC) for Adults With Troublesome Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to test the feasibility and acceptability of an online intervention for people with troublesome asthma in primary care, involving a consultation with a primary care clinician to introduce and promote online peer support (i.e. support from other patients with asthma within an established and safe OHC). The main questions this study aims to answer are: – Is the intervention feasible and acceptable to patients? – … |
ANNA DE SIMONI; | 2023-07-01 |
| 316 | The Impact of Clinical Pharmacist Intervention on Asthmatic Patient’s Outcomes at The University of Gondar Comprehensive and Specialized Hospital, Northwest Ethiopia, 2022: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this trial is to determine whether or not clinical pharmacist led intervention for 3 months improves asthma control of asthmatic patients’ outcomes as compared to the usual care 2023. The main question it aims to answer is does clinical pharmacist led interventions improve patient outcomes of asthmatic patients? Patients in the intervention group will receive a protocol-defined intervention at the start of the study and at the 1- , 3 and 6-month follow-up visits. Patients in the control group will receive the usual pharmacist care. |
EDEN ABETU MEHARI; | 2023-06-27 |
| 317 | A Randomized, Placebo-Controlled, Double-Blind, Multicenter, Phase 2 Study to Assess The Efficacy and Safety of Daily OM-85 Treatment Vs. Placebo Given in Children Aged 6 Months to 5 Years With Recurrent Wheezing PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the efficacy and safety of daily OM-85 treatment compared to placebo in children aged 6 months to 5 years with recurrent wheezing |
OM PHARMA SA | 2023-06-20 |
| 318 | Impact of Smoking Cessation Duration on Postoperative Complications in Lung Cancer Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the relationship between the duration of smoking cessation before surgery and postoperative complications in lung cancer patients undergoing surgery. Lung cancer surgery patients who have recently quit smoking or are long-term nonsmokers will be evaluated to determine if the timing of smoking cessation impacts the risk of complications after surgery. By analyzing these factors, the study seeks to provide guidance on optimal smoking cessation timing to reduce postoperative risks. |
CANER İŞEVI; | 2023-06-15 |
| 319 | The Effect of Health Promotion Comprehensive Education Intervention on The Frailty Levels of Elderly Family Caregivers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was conducted to evaluate the effect of a comprehensive health promotion educational intervention applied to family caregivers over the age of 60 on their fragility levels. The main question(s) it aims to answer are: – Does the educational intervention have a significant impact on caregivers’ vulnerability? – … |
FATMA BANU DEMIRDAS; | 2023-06-15 |
| 320 | Environmental Mycobiota: In-depth Characterisation and Determinants Involved in Asthma Emission PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The analysis of the exposome of severe asthmatic patients and its correlation with the response profile to biotherapies used in the treatment of severe asthma and/or the frequency of exacerbations, could make it possible to identify individual and environmental components influencing the evolution of the asthmatic pathology and/or response to treatment. An interventional approach could thus be developed, … |
SÉBASTIEN IMBERT; | 2023-06-15 |
| 321 | Supporting Parents to Choose Wisely: A Multi-Method Study to Increase Knowledge and Manage Expectations for Common Acute Childhood Conditions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this multi-method study including a randomized control trial and qualitative interviews is to see how useful blogshots (an image that summarizes information) are at helping parents increase their knowledge and manage their expectations for common acute childhood conditions (e.g. sore throat, ear infection) with respect to Choosing Wisely Canada recommendations. Participants will be randomly assigned to Group A or Group B in this study. Group A will receive three of six blogshots over a 4-week period (a different blogshot will be sent by email to them each week for three weeks, … |
LISA HARTLING; | 2023-06-05 |
| 322 | Increase in Inhaled Corticosteroid Dose Vs Triple Therapy in T2-high Asthma Patients Who Remain Uncontrolled With Medium Dose Inhaled Corticosteroids/Long-acting Β2 Adrenergic Combination: A Real-life Study. TRICORDA Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Increase in inhaled corticosteroid dose vs triple therapy in T2-high asthma patients who remain uncontrolled with medium dose inhaled corticosteroids/long-acting β2 adrenergic combination: a real-life study. |
LUIS PÉREZ DE LLANO; | 2023-06-01 |
| 323 | Response and Remission to Treatment With Anti-IL5/IL5R Antagonists in A Real-world Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this retrospective observational study is to compare the response and remission rate after treatment with IL5/IL5-R antagonists in asthmatics who would and would have not met the inclusion criteria of the original randomized clinical trials. This study will be performed using the charts of the patients. |
CATHERINE LEMIERE; | 2023-06-01 |
| 324 | Evaluation of The Efficacy and Mechanism of Action of Huang-long Zhi-xiao Granule to Improve The Control Rate of Chronic Persistent of Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to test the Evaluation of the efficacy and mechanism of action about Huang-long Zhi-xiao Granule to improve the control rate of Asthma chronic duration. The main questions it aims to answer are: – [Relying on the top-level experimental design, scientifically evaluated the efficacy and safety of Huang-long Zhi-xiao Granule in patients with chronic asthma (hot asthma), and provided evidence support for the clinical application of Classical Prescriptions.] – [Through the retained sample to test Asthma-related inflammatory indicators, immunoglobulins, T cell subsets, … |
MINGHANG WANG; | 2023-06-01 |
| 325 | Impact of Exercise on Asthma Control and Management in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate if physical activity could improve asthma control and management in adults. With this purpose we enroll asthmatic patients between 18-65 years old, and randomized them into 2 groups: in the first, patients will receive some workshops about asthma en physical exercise; … |
INSTITUTO DE INVESTIGACIÓN SANITARIA DE LA FUNDACIÓN JIMÉNEZ DÍAZ | 2023-06-01 |
| 326 | Evaluation of 3D Magnetic Resonance Spirometry: Comparison with Spirometry in Healthy Subjects and Patients with Respiratory Pathologies (asthma, COPD, Bilateral Lung Transplant) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Spirometry is now the gold standard technique for assessing lung function in humans. From the shape of a flow-volume curve measured while the patient, trained by the practitioner, performs forced breaths, the forced vital capacity (FVC) and the forced expiratory volume in one second (FEV1) can be deduced and the pulmonologist is able to detect and characterize respiratory diseases as well as to evaluate current treatments. This technique is non-invasive and simple. It is widely available, robust, reproducible and sensitive to intervention. However, it requires proactive cooperation from the patient and only measures global pulmonary ventilation, … |
VINCENT LEBON; | 2023-05-26 |
| 327 | Agreement Between Accelerometric and Acoustic Signals Utilizing Algorithm and Body Plethysmograph in Detecting Nasal and Oral Specific Airway Resistance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the agreement between sensors analyzing algorithm and body plethysmography in measuring oral and nasal breathing in healthy adults, and in patients with chronic rhinosinusitis, asthma and chronic obstructive pulmonary disease. The main question it aims to answer is: • Is the algorithm-based method accurate enough in analyzing respiratory obstruction as compared to body plethysmography (reference method)? Participants will perform a short breathing protocol (oral and nasal breathing with different masks) during which time their breathing is monitored with both methods. |
OLLI-PEKKA ALHO; | 2023-05-23 |
| 328 | A Cross-sectional Study Using Cardio-pulmonary Exercise Stress Testing to Understand Physiological Differences in T2-biomarker Low Severe Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational pilot study is to use exercise-testing to assess patients with severe asthma who have high levels of breathlessness and compare them to other groups of patients with low levels of breathlessness. We will compare the background and overall fitness levels in all groups. This may provide new knowledge to why these patients remain breathless despite being on treatment with low levels of inflammation. The main question we aim to answer is: How are these patients different compared to patients who respond to treatment? We will look at reasons why patients with low levels of inflammation in their lungs are still breathless despite being on treatment. Participants will be required to take part in a 6-month study were they will firstly attend a study visit and a 6 month follow up. At the study visit participants will be consented and required to: – Complete questionnaires on their symptoms – Provide information on their background – Undergo a physical examination – Provide blood and urine samples for specific testing for asthma and future investigations – Perform breathing tests – Undergo an exercise-test on a treadmill During this study, researchers will compare this group will to participants who are similar but whose symptoms respond to treatment. We will also look at other groups of asthma patients who have who have different levels of inflammation in their lungs to see if there are any differences. We predict, these patients will have a different background and features to those whose symptoms respond to treatment. |
LIAM HEANEY; | 2023-05-21 |
| 329 | Evaluating Bronchodilator Response in Patients With Bronchiectasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Although patients with bronchiectasis tend to have non reversible obstructive patterns on pulmonary function tests (PFTs), reversible obstruction is not uncommon. While bronchodilator response (BDR) is a main characteristic of asthma, the pathophysiology causing this phenomenon in bronchiectasis patients is less clear. The goal of this clinical trial is to assess BDR in patients with bronchiectasis. The main aims of this study: 1. To evaluate the role of bronchodilators in BDR testing of patients with bronchiectasis. 2. Characterize and compare BDR between different subgroups of patients with bronchiectasis, … |
MORDECHAI POLLAK; | 2023-05-20 |
| 330 | The Evaluation of The Effect of Piezo and Endonasal Osteotomy Methods on Postoperative Healing Process in Septorhinoplasty By The Ultrasonic Measurement of Nasal Skin Thickness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare the effect of Piezo and endonasal osteotomy techniques on the healing process of patients undergoing septorhinoplasty surgery. The main question[s] it aims to answer are: – In which osteotomy technique the edema is lesser? – Which osteotomy technique is better for thick vs thin skinned patients ? In which osteotomy technique the healing process is faster? Participants will be asked to have an ultrasonic measurement of the nasal dorsum preoperatively and at the first, … |
ISIL TAYLAN CEBI; | 2023-05-19 |
| 331 | A Phase 1 Study to Confirm The Single- and Multiple-dose Pharmacokinetics and to Evaluate Food Effect of Vapendavir in Healthy Participants and Participants With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vapendavir (VPV) is potent virostatic antiviral agent active against all known enterovirus species. VPV binds to the viral capsid, thereby inhibiting viral attachment to the target cell and, independently, preventing release of viral RNA (ribonucleic acid) into the cell. Alt VPV-101 is meant to investigate vapendavir in patients with chronic obstructive pulmonary disease (COPD) who develop a rhinoviral infection. This is a Phase 1, open-label, … |
DAVID WYATT; | 2023-05-19 |
| 332 | Epigenetic Modulation Drives Chronic Type 2 Chronic Rhinosinusitis With Nasal Polyposis: Identifying Markers, Pathogens and Mechanisms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background/rationale While multiple disorders feature a Type 2 (T2) inflammation, triggers for T2 remains unknown. In Chronic Rhinosinusitis with Nasal Polyposis CRSwNP), a classic Type 2 disorder, dysfunction of the epithelial barrier is suggested by loss of epithelial cell differentiation, impaired response to wounding, and impairment of innate defense mechanisms. After unsuccessful attempts to describe T2 disorders solely by host genetic or environmental factors, the role of epigenetics in the modification of innate immune response and epithelial integrity appears an important unexplored mechanism for a novel appreciation of T2 disease. In addition, … |
MARTIN Y. DESROSIERS; | 2023-05-18 |
| 333 | Enhanced Community-Based Asthma Monitoring Through Novel Technology PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot interventional study is to learn about the implementation of a home monitoring program (using remote study visits and lung function testing) in children with asthma. The main questions to answer are: 1. Do participants find the program to be feasibile, acceptable and accessible? 2. What factors are associated with completion of the program? 3. Does the program have an effect on asthma control and daytime sleepiness? |
ABIGAIL R STRANG; | 2023-05-15 |
| 334 | Effects of BBT Versus Diaphragmatic Breathing on Exercise Capacity and Quality of Life in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Group A will be treated with manual chest physical therapy and Buteyko breathing technique Group-B will be treated with manual chest physical therapy and Diaphragmatic breathing technique. Patients will perform the technique 5 times a weeks for 8weeks and treatment evaluation will be done after 8 weeks |
SIDRA FAISAL; | 2023-05-15 |
| 335 | Comparative Effects of BBT and Active Cycle of Breathing Technique on Dyspnea and Quality of Life in COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparative effects of Butyeko breathing technique and Active Cycle of Breathing technique on dyspnea and quality of life in patients with chronic obstructive pulmonary disease |
SIDRA FAISAL; | 2023-05-15 |
| 336 | Double-blind, Randomized, Active-controlled, Two-way Cross-over Study, With 12-week Treatment Duration Per Period, to Evaluate The Efficacy and Safety of QMF149 (Indacaterol Acetate / Mometasone Furoate) Compared to Budesonide in Children From 6 to Less Than 12 Years of Age With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the superiority in terms of efficacy and evaluate the safety of QMF149 (indacaterol (acetate) / mometasone (furoate)) compared to budesonide in children from 6 to less than 12 years of age with asthma. * The study duration will be up to 37 weeks including an investigational treatment duration of 12 weeks and a comparator treatment duration of 12 weeks. * The visit frequency will be 3 weeks for screening, run-in and wash-out period, 6 weeks interval for visits during each treatment period, 30 days for safety follow-up. |
NOVARTIS PHARMACEUTICALS | 2023-05-11 |
| 337 | Asthma Crisis in Paediatrics: Impact of A Care Pathway in Primary and Hospital Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effect of the implementation of the new Asthma Integrated Care Pathway in the Basque Healthcare Service for the improvement of care for children with asthma attacks and the reduction of variability between professionals and care settings in this care practice. Asthma is the most common chronic disease in children and has a major impact on people’s quality of life. The Asthma Integrated Care Pathway is a structured multidisciplinary care plan that details the essential steps in the care of patients with mild-moderate asthma attacks and the coordinated practice of the agents involved as dictated by the evidence. This pathway will include quality indicators of compliance with diagnostic criteria, assessment of severity and prescription of drugs, as well as the experience of families and professionals, which have been collected in meetings designed for this purpose. The study consists in a mixed methods implementation trial with two phases: 1. Phase I: a quantitative evaluation will be carried out to assess implementation outcomes at the professional level through a pretest-posttest quasi-experimental study with paired control group, with a ratio of 1:2. The primary outcome variable will be the overall percentage of bronchodilator treatment with a spacer chamber in children diagnosed with mild-moderate asthma attacks. We will also include as outcomes to be measured the registration rate of the Pulmonary Score, the recording rate of the assessment of persistent asthma symptoms, and the rate of initiation of background treatment in children with persistent asthma symptoms. These variables will be analysed using differences in pre- and post-intervention outcome measures between the intervention and control groups. 2. Phase II: a qualitative evaluation will be carried out through a structured process with discussion groups focused on the identification of the main barriers and facilitators for the provision of recommended clinical practice related to asthmatic crisis in mild-moderate cases established by the Asthma Integrated Care Pathway. A purposive sample of paediatricians stratified by level of care and service organisations will be recruited to ensure that all views are represented in the discussion groups. The structured script will be designed with questions to explore each of the domains of the Theoretical Domains Framework (TDF). The study will be carried out mainly in two integrated healthcare organizations (IHO), which are made up of two primary care areas and the paediatric reference hospital emergency department of both areas, as well as the hospitalisation, intensive care and paediatric pneumology departments of said hospital, to extend in the future the Asthma Integrated Care Pathway to the rest of the Basque Health Service IHOs. |
MARTA MONTEJO FERNANDEZ; | 2023-05-07 |
| 338 | ACTION (physicAl ACtiviTy In MinOrity WomeN With Asthma) Intervention: Efficacy to Implementation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Physical inactivity is associated with poor asthma control and quality of life, and greater health care utilization. Rates of physical inactivity, asthma, and asthma mortality among Black women are higher than those of their White counterparts. Our formative work identified barriers to PA among Black women with asthma including a lack of social support, self-efficacy, unsafe neighborhood and fear related to experiences with life-threatening asthma exacerbations. Given the unique barriers to PA and high rates of physical inactivity that are associated with poor asthma outcomes in Black women, … |
SHARMILEE NYENHUIS; | 2023-05-04 |
| 339 | Randomized, DB, Crossover Study to Assess Bronchospasm Potentially Induced By HFO MDI Vs. HFA MDI Propellant in Participants With Asthma Well/Partially Controlled on SABA With or Without Low-Dose ICS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A study to assess bronchospasm potentially induced by HFO MDI as compared with HFA MDI in participants with well controlled or partially controlled asthma |
DAVID MILLER; | 2023-05-02 |
| 340 | The Measurement of Vital Signs in Children By Lifelight® Software in Comparison to The Standard of Care The VISION-Junior Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective basic science study for collection of training and testing data for development of Lifelight® Junior |
NIALL MULLEN; | 2023-05-01 |
| 341 | The Development and Pilot Testing of A Caregiver-Child Shared Decision-Making Intervention to Improve Asthma in Urban Youth PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aims of this study are to develop and pilot test BRief intervention to Evaluate Asthma THErapy (BREATHE)-Peds, a dyadic shared decision-making intervention, to improve asthma by supporting self-management among racial and ethnic minority early adolescents receiving care for uncontrolled asthma in federally-qualified health centers (FQHCs) in urban communities. Aim 1 (Phase I) involves developing the intervention through focus groups with early adolescents and caregivers. Aims 2 and 3 (Phase II) involve preliminary testing of the intervention through a pilot randomized controlled trial. This record is for Phase II and III only |
MAUREEN GEORGE; | 2023-05-01 |
| 342 | Study of The Effect of Breast Milk and Hamamelis Virginiana (Potency12MG/100G) on The Healing of Diaper Dermatitis in Infants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diaper dermatitis, one of infants’ most common health problems, can be treated with various methods. One of these methods is breast milk. Studies show that breast milk is a non-harmful, accessible and effective product in the healing of dermatitis. This study was planned to be a randomized, controlled, … |
DÖNDÜ 1 SEVIMLI GÜLER; | 2023-05-01 |
| 343 | Effectiveness, Acceptability and Feasibility of KmAsthma Self-management App in IMprovIng The ContRol Of ASthma (MICROS) Among Day Scholar Secondary School Adolescents in Kampala City Uganda: A Pilot Cluster Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Uganda experiences high morbidity and costs due to uncontrolled asthma. Poor asthma control in adolescents is partly attributed to inadequate asthma education; indicating that education and self-management programs are essential components of asthma control. Adolescents with poorly controlled asthma are reported to have improved asthma control after using a smart phone application in outpatient setting studies. However, there is paucity of data on the effectiveness, feasibility and acceptability of smart phone applications in the control of asthma among adolescent secondary school students in low resource settings. |
JAMES DAVIS KATUMBA; | 2023-05-01 |
| 344 | Beyond The Eosinophil: Understanding The Impact of Eosinophil Depletion on T2 Inflammation. (BEUTI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Benralizumab is a relatively new treatment that is approved by NICE (National Institute for Health and Care Excellence, https://www.nice.org.uk/) for patients with severe asthma who have ongoing eosinophilic inflammation that remains poorly controlled despite high dose inhaled glucocorticosteroid medication. Eosinophils are a type of white blood cell that are linked to allergy and inflammation and are raised in people with severe asthma. Severe asthma is associated with a type-2 (T2) inflammation phenotype characterised by increased T2 cytokines (IL-13, IL-4, IL-5). Increased levels of eosinophils can cause inflammation in the lungs, … |
DAVID JACKSON; | 2023-05-01 |
| 345 | Predictors Of Chronic Thromboembolic Pulmonary Hypertension Following Acute Pulmonary Embolism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Identify risk factors for developing chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Determine echocardiographic predictors of chronic thromboembolic pulmonary hypertension. Determine the radiological predictors of chronic thromboembolic pulmonary hypertension in CT pulmonary angiography. |
ASMAA GAMAL ABD ELHAMIED; | 2023-05-01 |
| 346 | Comparing Paper Letters in Addition to Emailed Audit and Feedback in Refining Asthma Treatment to Improve Clinical and Environmental Results in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Public Health England have estimated that 36,000 excess deaths occur each year due to UK air pollution. Respiratory inhalers produce 3% of NHS greenhouse gas production. The two main inhaler device categories are pressurised Metered Dose Inhalers (pMDIs) and Dry Powder Inhalers (DPIs). The chemical propellant in pMDIs is the majority cause of inhaler carbon footprint, … |
OWEN THOMAS; | 2023-04-24 |
| 347 | An Open-Label, Single-Arm Study in Moderate Asthma Participants Comparing The Treatment With Long-Acting Beta Agonist Between At-Home Mobile Spirometry and In-Clinic Spirometry (LEARN) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional study is to compare at-home mobile spirometry to in-clinic spirometry in participants with moderate asthma while taking a long-acting beta agonist (LABA). The main questions it aims to answer are: – Do at-home mobile spirometry and in-clinic spirometry assessments show a similar treatment effect (measured changes in FEV1) with the addition of LABA? – Is at-home mobile spirometry as accurate as in-clinic spirometry in showing treatment effects (changes in FEV1)? Participants will be asked to: – Take standard of care LABA treatment once a day – Complete at-home mobile spirometry testing twice a day – … |
LINDA FORD; | 2023-04-21 |
| 348 | Real-world Experience of Dupilumab for The Treatment of Severe Asthma in The United Kingdom: A Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this retrospective medical record review is to describe the real-world clinical effectiveness of dupilumab with patients in the United Kingdom with severe asthma. |
SANOFI | 2023-04-19 |
| 349 | A Randomized, Parallel-group, Open, Two-period, Comparative Non-inferiority Study of Eurofarma’s Formoterol/budesonide Vs Alenia in The Treatment of Moderate to Severe Persistent Asthma with and Without Chronic Obstructive Pulmonary COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A phase III study, multicenter, randomized, parallel, open, two-period, comparative non-inferiority of Eurofarma versus Alenia® in the treatment of moderate to severe persistent asthma with and without obstructive pulmonary disease (COPD). ⚠️study will only be conducted in research centers in Brazil (please do not send e-mail if your center is outside brazil). |
EUROFARMA LABORATORIOS S A | 2023-04-19 |
| 350 | A Randomized Controlled Trial of Concentrated Investment in Black Neighborhoods to Address Structural Racism As A Fundamental Cause of Poor Child Health PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Black children and adults in the United States fare worse across nearly every health indicator compared to White individuals. In Philadelphia, the location of this study, these health disparities result in a stark longevity gap, with average life expectancies in poor, predominantly Black neighborhoods being 20 years lower than in nearby affluent, predominantly White neighborhoods. The investigators will conduct a cluster randomized controlled trial (RCT) of a suite of place- based and financial-wellbeing interventions at the community, organization, and individual/household levels that address the social determinants of racial health disparities. At the community level, … |
ATHEENDAR VENKATARAMANI; | 2023-04-17 |
| 351 | A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method） PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate diagnostic performance of N-terminal Brain natriuretic Peptide (NT-proBNP) in acute heart failure among Chinese population. Further, it sought to explore the optimal cut-off point fitting Chinese patients. |
BECKMAN COULTER | 2023-04-10 |
| 352 | Efficacy and Safety of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A study to evaluate the efficacy and safety of benralizumab administered subcutaneously in patients ≥ 6 to \< 18 years of age with severe eosinophilic asthma, including a well-documented history of asthma exacerbations and uncontrolled asthma receiving high-dose inhaled corticosteroid (ICS) plus at least one additional controller medication. |
ASTRAZENECA | 2023-04-05 |
| 353 | Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center study of 80 subjects with asthma including those with obesity and metabolic dysfunction (MD), those with obesity and without metabolic dysfunction, those with severe asthma and mucus plugging and those with severe asthma and without mucus plugging. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in a cardiopulmonary exercise testing (CPET) visit to compare lung function markers and change in oxygen saturation between obese patients with and without MD and severe asthma patients with and without mucus plugging. |
JOHN FAHY; | 2023-04-05 |
| 354 | TEZSPIRE Subcutaneous Injection 210mg Specific Use-results Study (Long Term) in Patients With Bronchial Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the investigation is to confirm the followings under the post-marketing actual long-term use of Tezspire. 1. Development of related AEs 2. Contributing factors possibly having an impact on the safety and effectiveness 3. Development of unexpected related AEs |
ASTRAZENECA | 2023-04-04 |
| 355 | Evidence Driven Indoor Air Quality Improvement PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim is to identify the underlying disease mechanisms driving specific asthma phenotypes as well as certain disease outcomes and their relation to impaired indoor air quality. This may also help in underpinning specific target mechanisms in order to personalize and improve current treatment options in childhood asthma and develop more successful prevention strategies. This will be done by combining data from detailed clinical phenotyping with multiple -omics data. |
MIRJANA TURKALJ; | 2023-04-03 |
| 356 | A Randomized, Double-Blind, Placebo-Controlled Phase Ⅱ Clinical Study to Evaluate The Efficacy and Safety of CM326 in Subjects With Moderate to Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-center, randomized, double-blind, placebo-controlled Phase Ⅱ clinical study to evaluate the efficacy, safety, PK characteristics, PD effects and immunogenicity of CM326 in subjects with moderate to severe asthma. The study consists of three periods, including an up to 4-week screening period, a 52-week treatment period, and a 12-week safety follow-up period. |
JIEMING QU; | 2023-04-01 |
| 357 | Study on Hospitalization of Children With Bronchial Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchial asthma is the most common chronic respiratory disease in children. At present, more attention has been paid to the treatment of airway inflammation and smooth muscle spasm, while the related research on the risk factors of asthma attack, mucus plug formation and its effect on asthma has been ignored. This study was a retrospective study. Children hospitalized for acute exacerbation of asthma from 2016 to 2021 were selected as the research objects. The clinical manifestations, bronchoscopy results and lung CT results of children hospitalized for acute exacerbation of asthma were summarized. To analyze the risk factors of acute exacerbation, … |
KUNLING SHEN; | 2023-04-01 |
| 358 | A Pilot Pragmatic Randomized Controlled Trial to Evaluate The Impact of Improving Access to Drugs on Type 2 Diabetes Care, Outcomes and Costs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Canada is the only country with a universal health insurance system that does not provide coverage for prescription drugs to all residents. One-third of working-age Canadians have no insurance. Importantly, many of these uninsured patients already face other barriers to good health: low income, new immigrants, single mothers, etc. For these patients, taking prescription drugs – especially chronic disease treatments that may be required lifelong – can be difficult due to high costs. Patients skip doses, delay renewing prescriptions, or simply do not fill prescriptions recommended by their doctors, … |
SUNNYBROOK HEALTH SCIENCES CENTRE | 2023-04-01 |
| 359 | A Phase 2 Multi-centre Randomized Double-blind Placebo-controlled Parallel Group Study to Examine The Effects of 24 Weeks Tezepelumab 210 Mg Sc Q4wks on Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a condition where small inhaled particles can cause inflammation in the lung leading to constriction of airways and wheeze. Mast cells are immune cells in airways that can release chemical causing constriction of the airways and wheeze. Tezepelumab is an injectable medication that improves asthma by stopping inflammation, but the effect on mast cells is not known. Tezepelumab was approved in Canada July 2022 for treatment of severe asthma. Tezepelumab is not approved for treatment of mild asthma by any health authority, … |
GAIL GAUVREAU; | 2023-04-01 |
| 360 | Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease. |
FUNDACIÓ INSTITUT DE RECERCA DE L’HOSPITAL DE LA SANTA CREU I SANT PAU | 2023-04-01 |
| 361 | Assessing The Efficacy of Antipyrine Benzocaine Otic Solution in The Ear Canal to Decrease Usage of Rescue Inhalers in Moderate to Severe Asthmatic Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double-blind, randomized, placebo-controlled, proof of concept, study in adults with poorly controlled moderate to severe asthma. The researchers believe that by using a local anesthetic to block a certain nerve in the ear, it will improve all aspects of asthma, such as decreasing the numbers of times patients have to use a rescue inhaler, and improving asthma treatment assessment questionnaire scores, with no bad changes to lung function and inflammation. |
JOHN D PROSSER; | 2023-04-01 |
| 362 | The Role of Biomarkers in The Occurrence and Development of Asthma Related Papers Related Patents Related Grants Related Experts View Highlight: To study the expression level of biomarkers such as GITRL in peripheral blood of children with asthma and analyze their correlation with the severity of asthma. To study the predictive value of biomarkers level for the occurrence and development of asthma. And to provide supplementary detection means and predictive indicators for the diagnosis of asthma and the severity of asthma. |
FENGXIA DING; | 2023-04-01 |
| 363 | The Effect of Buteyko Breathing Technique on Asthma Control and Quality of Life in Children Aged 7-12 With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the effect of buteyko breathing technique applied in children aged 7-12 years with asthma disease on asthma control and quality of life is examined. Asthma is a serious global health problem affecting all age groups. In studies conducted with the ISSAC (International study of asthma and allergies in childhood) method, the prevalence of asthma varies between 4-23% in developed populations. In childhood prevalence studies in our country, … |
EMEL YÜRÜK; | 2023-03-30 |
| 364 | In Vivo Efficacy of Salbutamol (Sandoz) Versus Salbutamol Ventolin (GSK) in Children With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators hypothesize that the reference product (SalbR/Ventolin) is more effective than SalbG (Salbutamol Sandoz) at improving the lung function in children with asthma, … |
ELLEN CROONEN; | 2023-03-30 |
| 365 | Investigating The Impact of London’s Ultra Low Emission Zone on Children’s Respiratory Health PF:6 Related Papers Related Patents Related Grants Related Experts View Abstract: Strong evidence links urban air pollution to restrictions in children’s lung growth and development and other adverse effects, including increases in respiratory and allergy … |
QUEEN MARY UNIVERSITY OF LONDON | 2023-03-29 |
| 366 | Mechanistic Trial of Dupilumab in Adults With House Dust Mite-associated Asthma Using An Aeroallergen Challenge Chamber PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The trial involves two interventions: (i) exposure to HDM in the ACC and (ii) administration of dupilumab/placebo for dupilumab. |
SUNIL AHUJA; | 2023-03-29 |
| 367 | Cough Capture As A Portal Into The Lung-ICTR Pilot PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The lung is a privileged organ; blood does not reflect most lung processes well, if at all. Therefore, for population scale diagnostics, the investigator team is developing non-invasive portals to the lung, for eventual early detection/risk assessment and diagnostic purposes. However, large macromolecules are not likely suspended nor readily detected in the breath. In particular, genomic DNA in the breath condensate (EBC) is very sparse, and where present, generally highly fragmented, not readily amenable to sequencing based assessments of DNA somatic mutation burden or distribution. Because gDNA (and protein) is challenging to obtain non-invasively from EBC, … |
SIMON D SPIVACK; | 2023-03-28 |
| 368 | A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess The Efficacy, Safety, and Tolerability of Dexpramipexole Administered Orally for 52 Weeks in Participants With Severe Eosinophilic Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this clinical study is to investigate the safety, tolerability, and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma. |
MICHAEL E. WECHSLER; | 2023-03-27 |
| 369 | A Phase 3, 24-week, Randomized, Double-blind, Parallel-group Bayesian Dynamic Borrowing Study Comparing The Efficacy, Safety, Tolerability and Pharmacokinetics of FF/UMEC/VI With FF/VI in 12-17-year-old Participants With Inadequately Controlled Asthma on Stable Maintenance Therapy With ICS/LABA PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to evaluate the effects of Fluticasone Furoate (FF)/ Umeclidinium (UMEC)/ Vilanterol (VI) on lung function compared with FF/VI after 24 weeks of treatment. |
GLAXOSMITHKLINE | 2023-03-16 |
| 370 | Videoconferencing-based Focused Acceptance and Commitment Therapy for Parents of Children With Special Health Care Needs: A Non-randomised Controlled Feasibility Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the proposed non-randomized waitlist-controlled design study is to evaluate the feasibility, acceptability, and potential effectiveness of using a Videoconferencing-based Individual Focused Acceptance and Commitment Therapy (FACT) approach to enhance the mental well-being of parents of children with special healthcare needs (SHCN) over a three-month period after the intervention has taken place. |
YUEN YU CHONG; | 2023-03-15 |
| 371 | REVErsing Airway Remodelling With Tezepelumab : A Protocol for A Double-blind Randomized Controlled Trial for Patients With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this protocol is to perform a first randomized controlled trial evaluating how Tezepelumab affects the bronchial morphology (and computed tomographic variables in general) of asthmatic patients. In parallel, … |
ARNAUD BOURDIN; | 2023-03-15 |
| 372 | Comparison of Dynamic Respiratory Muscle Strength and Endurance, Physical Activity Level and Physical Fitness in Asthmatic Children and Their Healthy Peers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Peak inspiratory flow (PIF) may be due to respiratory muscle strength, especially in those with severe airflow obstruction. PIF appears to be lower in children and adolescents with asthma than in non-asthmatics and correlates positively with age, height, weight, and respiratory muscle strength. Although physical activity and fitness are also believed to be important in lung health, the relationship between lung function and physical fitness is unclear. It measures dynamic lung volumes, s-index and PIF and provides information on dynamic lung function in children and adolescents. In this study, … |
ŞEYMA NUR ÖNAL; | 2023-03-13 |
| 373 | Added Diagnostic Value of Point of Care Ultrasound in Acute Dyspnea: A Prospective Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnea is a common diagnostic challenge in the Emergency Department (ED). Delay in diagnosis will increase time to correct treatment and could impact outcome. Previous studies have shown excellent diagnostic performance of point of care ultrasound (POCUS) to detect and differentiate between several important diagnosis (e.g heart failure and pneumonia) in patients with dyspnea. However, … |
JAKOB LUNDAGER FORBERG; | 2023-03-09 |
| 374 | Phase IIa Clinical Trial to Evaluate Pharmacokinetics and Safety of Slow Release DHEA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to look at pharmacokinetic levels of different doses of slow release DHEA in subjects with asthma. |
KIRSTEN KLOEPFER; | 2023-03-03 |
| 375 | The Nationwide Real-world Status of Oral Corticosteroid Use in Patients With Asthma PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The Health Insurance Review and Assessment Service (HIRA) database contains nationwide claim data. By utilizing this database, the investigators aimed to analyze the current status of OCS use in South Korea by using HIRA database. |
JOON YOUNG CHOI; | 2023-03-01 |
| 376 | Evaluating The Efficacy of Allergen Immunotherapy in The Management of Allergic Asthma and Rhinitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Allergy is defined as a specific abnormal and excessive reaction of the immune system to exposed allergen . This reaction is reproducible with each new exposure allergen . A recent study by The European Academy of Allergy and Clinical Immunology (EAACI) estimates that 30% of the population suffers from allergic rhinitis and/or conjunctivitis, 20% of children suffer from asthma, and 8% of the population suffers from food allergies in Europe, … |
HEDI GHARSALLAH; | 2023-03-01 |
| 377 | Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, randomized, SHAM-controlled, parallel assignment, double-masked,8-week interventional study among children aged 8-17 years (not yet 18 years old) of age with obesity and asthma. (n=60), recruited from Duke Health Center Creekstone, to test the effectiveness of inspiratory muscle rehabilitation (IMR) as an acceptable add-on intervention to reduce dyspnea (feeling short-of-breath or breathless) and to promote greater activity in children with obesity and asthma. Clinic to test the effectiveness of inspiratory muscle rehabilitation (IMR) as an acceptable add-on intervention to reduce dyspnea (feeling short-of-breath or breathless) and to promote greater activity in children with obesity |
JASON LANG; | 2023-03-01 |
| 378 | Effects of Moderate Intensity Interval Training and Sprint Interval Training on Patients Having Chronic Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the effects of moderate intensity interval training and sprint interval training on patients having chronic asthma. |
MALIK MUHAMMAD ALI AWAN; | 2023-03-01 |
| 379 | Impact of Modified Specific Carbohydrate Diet on Bronchial Asthma Control in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study will explore if the specific carbohydrate diet has an effect on asthma control in children and if it will affect the frequency, severity, and duration of asthma and thus provide it as a potential complementary treatment option for them. |
REHAB ZAKI ELMEAZAWY; | 2023-03-01 |
| 380 | Effect of Continuous Positive Airway Pressure (CPAP) on 6-Minute Walk Test Outcomes in Patients with Excessive Central Airway Collapse (ECAC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this protocol is to perform a prospective, randomized, double-blinded, pacebo-controlled clinical trial to determine the influence of a non-invasive positive pressure ventilation device on exercise capacity and symptoms in adult patients with ECAC. Primary outcome will include the total distance traversed by the study subject during a standard 6-minute walk test, and secondary outcomes will include peak flow measurement and symptom reporting before and after the exercise testing. The study will focus on the use of continuous positive airway pressure (CPAP) device. CPAP is FDA-approved for the treatment of various medical conditions, … |
ADNAN MAJID; | 2023-03-01 |
| 381 | Measure Airway Compliance By Endobronchial Optical Coherence Tomography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Optical Coherence Tomography （OCT）is a novel, non-invasive, high resolution special optical imaging techniques. In airway, Measure airway area and airway wall thickness is the most usage of Endobronchial Optical Coherence Tomography (EB-OCT）. Recently, the new protocol of EB-OCT is used to measure airway compliance, We will establish a new methodology of EB-OCT for measuring airway compliance, which will provide a new means to study respiratory diseases. |
XU HANG; | 2023-03-01 |
| 382 | A Randomized, Double-Blind, Parallel Group, Multicenter 12 Week Study to Assess The Efficacy and Safety of Budesonide and Formoterol Fumarate Metered Dose Inhaler Relative to Budesonide Metered Dose Inhaler in Participants With Inadequately Controlled Asthma (LITHOS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 12-week study to evaluate the efficacy and safety of budesonide and formoterol fumarate metered dose inhaler relative to budesonide metered dose inhaler in adults and adolescents with inadequately controlled asthma. |
ASTRAZENECA | 2023-02-27 |
| 383 | Effect of Intravenous Aminophylline on Hemodynamics and Recovery of Patients Undergoing Functional Endoscopic Sinus Surgery Under Dexmedetomidine Hypotensive Anesthesia: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to evaluate the effect of intravenous aminophylline on hemodynamics and recovery of patients receiving dexmedetomidine infusion during functional endoscopic sinus surgery. |
OSAMA REHAB; | 2023-02-25 |
| 384 | Comparison of The Efficacy of CRP, Procalcitonin and Pro-BNP As Diagnostic and Prognostic Markers in AECOPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) are one of the chief causes for admission to Emergency Department. AECOPD is a significant cause for mortality and morbidity worldwide. Emergency Medicine Physicians frequently manage these patients. Predicting the severity and possible prognosis of AECOPD is an important task for Emergency Medicine Physicians as treatment options and aggressiveness may depend on these predictions. In our study we aimed to compare different biomarkers such as Procalcitonin, … |
SERKAN DOĞAN; | 2023-02-15 |
| 385 | Psychological Characteristics of Patients With Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Like any chronic disease, asthma exposes individuals to stressful and threatening situations that require ongoing cognitive, emotional, behavioral and social adaptation. Approximately 5-10% of patients with asthma have a treatment-resistant disease, with frequent emergency room visits and hospitalizations. These patients are responsible for the majority of the overall asthma-related disease burden and also represent more than half of the total direct costs of asthma management. The scientific literature shows that personality traits, attachment type and psychological disorders will significantly influence disease coping strategies, disease experience, quality of life, adherence and therapeutic alliance. Although some data exist in asthma, … |
CENTRE HOSPITALIER UNIVERSITAIRE DE BESANCON | 2023-02-15 |
| 386 | Clinical Study of The Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19 Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to evaluate the safety and effectiveness of umbilical cord mesenchymal stem cell (UCMSC)-derived extracellular vesicle nebulization inhalation therapy for the treatment of chronic cough after COVID-19 infection. The main objective is to assess whether UCMSC-derived exosome nebulization inhalation therapy alleviates chronic cough after COVID-19. Participants will be asked to complete a questionnaire to help researchers evaluate their cough severity and to record their scores before nebulization inhalation of UCMSC-derived exosomes. Participants will receive either continuous nebulized inhalation of UCMSC-derived exosomes for 5 days, twice daily, … |
JIHUI DU; | 2023-02-15 |
| 387 | Early High-flow Oxygen Therapy With NebuLized Beta-2-agonist Using A Vibrating Mesh for The Management of Moderate to Severe Asthma Exacerbation in The Emergency Department PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute exacerbation of asthma represents an acute or sub-acute worsening in symptoms and lung function in patients with asthma. It is characterized by a progressive increase in symptoms of shortness of breath, cough, wheezing, or chest tightness. It is a common diagnosis in patients admitted in an Emergency Department for dyspnoea. Near 10 to 15% of respiratory symptoms in an ED are related to acute exacerbation of asthma. Treatment of acute exacerbation of asthma associates nebulized beta-2 agonist adrenergic with or without ipratropium bromide, … |
NICOLAS MARJANOVIC; | 2023-02-15 |
| 388 | Dupilumab and House Dust Mite Immunotherapy in Patients With Atopic Dermatitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe atopic dermatitis (AD) is a complex disease requiring systemic treatment. This study aimed to assess the effectiveness of combined therapy consisting of dupilumab and sublingual dust mite allergen immunotherapy (SLIT-HDM) in patients with severe AD and HDM allergies. Methods: Patients diagnosed with severe AD were included in a randomized, placebo-controlled, double-blind 12-month trial; they received SLIT to HDM and/or dupilumab for 12 months and were compared to patients on cyclosporine. EASI, %BSA, … |
ANDRZEJ BOZEK; | 2023-02-10 |
| 389 | The Use of Home Spirometry in The Monitoring of Patients With Acute Exacerbation of Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After outpatient clinic visit, asthmatic patients with worsening of symptoms (including dyspnea, wheezing, chest tightness, cough, activity limitation, awaken in the midnight due to discomfort) and are diagnosed of acute exacerbation by physician, will be recruited. The patients are asked to record symptoms using asthma symptom diary (ASD) with home spirometry simultaneously for 14 days. Visit 1 (day 1) All patients will be evaluated the following: 1. Record the patients’ demographics (age, gender, race), baseline characteristics, comorbidities, health care resources use (visits, lab tests, hospitalization and cost), pharmacological and non-pharmacological treatments 2. Blood sampling for eosinophils, … |
CHANG GUNG MEMORIAL HOSPITAL | 2023-02-07 |
| 390 | The Impact of Breath Exercises By Telemedicine in Patients Aged 8-18 Years With A Diagnosis of Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized, placebo controlled study is to evaluate the effect of respiratory exercises on asthma attack frequency, symptom and medication scores and quality of life of children with a diagnosis of asthma. Participants will be asked to perform respiratory exercises described at once in hospital at home regularly. Control group will comprised children with asthma without respiratory exercises. |
AYCA KIYKIM; | 2023-02-03 |
| 391 | Self-regulation for Older Adults With Asthma Through Remote Education PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research is studying whether changing an individual’s behaviors may have an impact as a treatment or outcome for asthma. The purpose of this study is to implement and evaluate an asthma self-management intervention through multiple locations in the United States that is tailored to the challenges older adults face and is based on an individual behavioral theory of change. Eligible participants will be enrolled and participate for six weeks in the SOAR intervention. |
ALAN BAPTIST; | 2023-02-02 |
| 392 | A Multicentre, Prospective, Non-interventional Trial Monitoring Therapy Pathways of Asthma Patients Treated With An Extra-fine ICS/LABA/LAMA Single-inhaler Triple Therapy in A Real-world Setting and Characterizing The Effects on Health-related Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: TriMaximize, a non-interventional trial aims to collect prospective, longitudinal data from asthma patients under routine care, for whom their treating physician has decided to prescribe Trimbow® (beclometasone/formoterol/glycopyrronium). |
CHIESI SAS | 2023-02-01 |
| 393 | Validation of A Questionnaire to Assess Bronchial Mucus Hypersecretion in Asthmatic Patients. Questionnaire T-sec (Secretion Test) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To design and validate a questionnaire that allows objective assessment of the level of bronchial mucus hypersecretion. |
ASTRID CRESPO-LESSMANN; | 2023-02-01 |
| 394 | Screening Moderate to Severe Obstructive Sleep Apnea With Wearable Device PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to find the best method to use Wellue O2 ring to screen for moderate to severe obstructive sleep apnea. The method that investigators use to screen for moderate to severe obstructive sleep apnea is oxygen desaturation index(ODI). The main questions of this study are 1. What is the best ODI to screen for moderate to severe obstructive sleep apnea? 2. What are the sensitivity, specificity and AUC of the study? In this study, … |
JAMES TISYAKORN; | 2023-02-01 |
| 395 | Validation Study With A Non-CE Marked Medical Device (MD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This interventional study aims to validate the cough detection device by automatically and continuously measuring the cough frequency with SIVA-MVP among chronic cough patients and in a real-world environment. |
SIVA HEALTH AG | 2023-02-01 |
| 396 | Study to Evaluate The Effect of Dose and Duration of Treatment of Itraconazole Administered As A Dry Powder for Inhalation (PUR1900) on Safety, Tolerability, and Potential Outcomes in Adult Patients With Asthma and Allergic Bronchopulmonary Aspergillosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about PUR1900 as an inhaled, antifungal therapeutic for the treatment of allergic bronchopulmonary aspergillosis (ABPA) in patients with asthma. The main questions it aims to answer are: 1. Is PUR1900 safe and well tolerated in adults with asthma and ABPA? 2. Is there an effect of daily administration of PUR1900 on potential outcome measures in adults with asthma and ABPA? 3. Is there fungal resistance to A. fumigatus? This study includes a 28-day screening period, a 112-day (16-week) treatment period, … |
MICHAEL E MANNING; | 2023-02-01 |
| 397 | Combined Effects of Diaphragm Strengthening and Accessory Muscles Stretchings in Asthma Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a multifactorial and chronic inflammatory disease in older patients affecting many people worldwide with high cost of pharmacological treatment and physiotherapy interventions. It is characterized by a variety of symptoms including airway inflammation, bronchial hyper-responsiveness, and transient and reversible airway obstruction. Typical clinical features include wheezing, coughing, resting and/or exertional dyspnea, and chest tightness. Lung hyperinflation affects ability to inspire and increases the work of breathing. Long and short acting corticosteroids and leukotriene are considered effective pharmacological interventions while inspiratory muscle training, incentive spirometry, purse lip breathing, … |
AMEENA AMJAD; | 2023-02-01 |
| 398 | Blood Leukocyte Profiling in Eosinophilic Type 2 Asthma: Influence of Systemic IL-5 Targeting PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this exploratory and observational prospective study is to study the composition and phenotypes of blood leukocytes collected from asthmatic patients before and after instantiated treatment with the interleukin-5 neutralizing antibody mepolizumab. Comparisons will be made to leukocyte profiles in patients already on mepolizumab treatment, asthma patients without any biological treatment, and non-diseased control subjects. |
JONAS ERJEFÄLT; | 2023-02-01 |
| 399 | The Effect of Close Follow-Up Home Based Pulmonary Rehabilitation on Exacerbation Frequency and Hospital Admission in Severe COPD Cases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a randomized controlled trial. The cases will be divided into two groups as the Homespirometer group and the control group. Breathing exercises, aerobic exercise and peripheral muscle strengthening will be performed in both groups. A home-type spirometer will be given to the homespirometer group and it will be requested to send the spirometric measurement every week. The cases will be called to the hospital for control and evaluated at baseline, 3rd, 6th and 12th months. Evaluations include assessments such as exercise capacity measurement, muscle strength measurement, disease attack frequency, symptom scoring. |
ESRA PEHLIVAN; | 2023-02-01 |
| 400 | The Effects of Dupilumab on Asthma Outcomes and IL-13Rα2 Signaling in Airway Epithelial Cells in Allergic Asthma With Comorbid BMI ≥ 30 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the role of dupilumab in the treatment of asthma with comorbid obesity. It is hypothesized that in airway epithelial cells, unique transcriptomic and proteomic expression patterns distinguish allergic and non-allergic patients with asthma and obesity and drive significant differential responses to dupilumab. It is further hypothesized that dupilumab will increase interleukin-13 receptor alpha 2 (IL-13Rα2) levels and/or signaling activity on airway epithelial cells isolated from allergic asthma patients with obesity. This is a pre-clinical research study of dupilumab-induced gene and protein expression analyses in nasal airway epithelial cells of adults with asthma and comorbid obesity. The study primarily seeks to: 1) assess the effect of dupilumab on transcriptomes, phosphoproteomes and secretomes of well-differentiated, primary airway epithelial cells as a function IL-13R subunit expression and IL-13Ra2 signaling, in allergic and non-allergic asthma patients with obesity; and 2) test whether dupilumab-induced gene and protein changes significantly correlate with parameters of airway inflammation in allergic and non-allergic asthma. |
LORETTA QUE; | 2023-02-01 |
| 401 | Expertise Asthma COPD Program with Digital Support PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim EXACT@Home is to create an evidence-based health program using e.g. questionnaires, a digital health platform and multiple digital devices to further improve the assessment of patients diagnosed with severe asthma. By better charting treatable traits (e.g. poor adherence, physical inactivity, dysfunctional breathing), we expect to improve the indication for the use of biologics. One the devices that will be used is also a medicinal product: a digital inhaler, which monitors adherence and inhaler technique through its connected application and aims to improve adherence and inhaler technique with reminders and notifications. Next to this an activity tracker, … |
HANS IN ‘T VEEN; | 2023-01-31 |
| 402 | A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess The Efficacy, Safety, and Tolerability of Dexpramipexole Administered Orally for 52 Weeks in Participants With Severe Eosinophilic Asthma PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the efficacy and safety of dexpramipexole as an adjunctive oral therapy in participants with inadequately controlled asthma with an eosinophilic phenotype and a history of asthma exacerbations. |
SALMAN SIDDIQUI; | 2023-01-30 |
| 403 | A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess The Efficacy, Safety, and Tolerability of Dexpramipexole Administered Orally for 24 Weeks in Participants With Eosinophilic Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate dexpramipexole as an add-on oral therapy in participants with inadequately controlled eosinophilic asthma to evaluate improvements in lung function, asthma control, and quality of life. In addition, the study will further evaluate the safety and tolerability of dexpramipexole in participants with eosinophilic asthma. |
MONA BAFADHEL; | 2023-01-30 |
| 404 | Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to analyze the immune profiles of patients with Chronic Rhinosinusitis with Nasal polyps (CRSwNP) with and without asthma before and after Mepolizumab. A group of participants with CRS without nasal polyps (CRSsNP) with asthma will be included to compare their immune profiles to CRSwNP. |
ANDREW THAMBOO; | 2023-01-30 |
| 405 | Comparative Effects of Using Black Seed (Nigella Sativa) and Cumin Seed ( Cuminum Cyminum) on Body Composition Profile of Obese Grade I PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this Randomized clinical trial is to compare effectiveness of of using black seed (Nigella sativa) and cumin seed (Cuminum cyminum) on Body composition profile of obese grade 1. The primary objective of this study is To compare effectiveness of of using black seed (Nigella sativa) and cumin seed (Cuminum cyminum) on Body composition profile of obese grade 1. Subjects will be given a consent form and after subjects read and sign the informed consent, they would be included in study according to eligibility criteria. |
WASEEM JAVAID; | 2023-01-27 |
| 406 | Quercus Ilex and Quercus Robur Allergen Extracts. Determination of The in Vivo Allergenic Potency in Histamine Equivalent Units (HEP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine the biological activity of Quercus illex and Quercus robur allergen extracts in histamine equivalent prick (HEP) units, in order to be used as in-house reference preparation (IHRP). |
JAVIER SUBIZA; | 2023-01-24 |
| 407 | Clinical Study on The Safety and Efficacy of Mesenchymal Stem Cell Exosomes in The Treatment of Coronavirus Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study aims to investigate the safety and efficacy of nebulized inhalation of extracellular vesicles derived from mesenchymal stem cells combined with standard therapy for COVID-19-infected individuals. The primary objective is to determine whether nebulized MSC-secreted extracellular vesicles may be a feasible approach to alleviate COVID-19-induced lung injuries and promote recovery. Participants will be allocated to receive either nebulized MSC-secreted extracellular vesicles twice a day (BID) for 5 days as the test group or nebulized saline solution twice a day for 5 days as the control group. Researchers will compare the test and control groups to evaluate the safety and efficacy of extracellular vesicles in combination with standard therapy. |
XIAOYING HUANG; | 2023-01-23 |
| 408 | Kinesio Tape Versus Myofascial Release of Respiratory Muscles on Athletes Performance With Exercise Induced Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose of this study was to compare between the effects of kinesio tap and myofascial release of respiratory muscles on exercise induced asthma |
KHALED MOHAMMED AHMED ZAKI; | 2023-01-20 |
| 409 | Patient-Reported Outcomes of Benralizumab in Real-World Use in Severe Eosinophilic Asthma Patients in Taiwan PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An open-label, single-arm, non-interventional, prospective, multicenter study involving primary data collection within real-world settings for patients who receive benralizumab for treatment of severe uncontrolled eosinophilic asthma |
ASTRAZENECA | 2023-01-19 |
| 410 | Randomized Stratified Controlled Clinical Study for Evaluating The Effectiveness of A Diet Program Designed for Reducing Body Weight Using Standard and Innovative Products in Obese Participants With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized stratified controlled clinical study for evaluate the effectiveness of a diet program designed for reduce body weight through standard and innovative products that are a substitute meal for weight management in a reduction diet in obese participants with asthma. |
MIRJANA TURKALJ; | 2023-01-17 |
| 411 | Comparative Study of Intermittent Oro-esophageal Tube Feeding Vs Nasogastric Tube Feeding in Tracheostomized Patients With Intracerebral Hemorrhage: Improving Clinical Outcomes and Safety PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter, prospective, randomized controlled clinical trail involved tracheostomized patients with Intracerebral Hemorrhage transferred to the Department of Rehabilitation Medicine of 4 hospitals in China between January 2023 to June 2023. The goal of this clinical trial is to compare the clinical effect of Intermittent Oro-esophageal Tube Feeding vs Nasogastric Tube Feeding in Tracheostomized Patients with Intracerebral Hemorrhage. The main questions it aims to answer are: Compared to Nasogastric Tube Feeding, can the Intermittent Oro-esophageal Tube Feeding better improve the nutritional status, extubation of tracheostomy tube, pulmonary infection, … |
HONGJI ZENG; | 2023-01-17 |
| 412 | A Multicentre, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 2 Study to Evaluate The Efficacy and Safety of SHR-1905 in Subjects With Severe Uncontrolled Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a phase 2 study of SHR-1905 in subjects with severe uncontrolled asthma. The purpose of the study is to evaluate efficacy and safety of SHR-1905 in subjects with severe uncontrolled asthma. |
SHANGHAI HENGRUI PHARMACEUTICAL | 2023-01-17 |
| 413 | Comparative Study of Effect of Intermittent Oral Enteral Nutrition Tube in Tracheostomized Patients With Intracerebral Hemorrhage PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter, prospective, randomized controlled clinical trail involved tracheostomized patients with Intracerebral Hemorrhage. The goal of this clinical trial is to compare the clinical effect of Intermittent Oro-esophageal Tube Feeding vs Nasogastric Tube Feeding in Tracheostomized Patients with Intracerebral Hemorrhage. The main questions it aims to answer are: Compared to Nasogastric Tube Feeding, can the Intermittent Oro-esophageal Tube Feeding better improve the nutritional status, extubation of tracheostomy tube, pulmonary infection, neurological deficit of Patients with Intracerebral Hemorrhage Compared to Nasogastric Tube Feeding, is the Intermittent Oro-esophageal Tube Feeding safer. Participants will be divided into two groups randomly, … |
MUHAMMAD | 2023-01-17 |
| 414 | Randomized Stratified Controlled Clinical Study for Evaluate The Effectiveness of A Diet Program Designed for Reduce Body Weight Using Standard and Innovative Products PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized stratified controlled clinical study for evaluate the effectiveness of a diet program designed for reduce body weight through standard and innovative products that are a substitute meal for weight management in a reduction diet. |
MIRJANA TURKALJ; | 2023-01-17 |
| 415 | An Open-label Randomized Comparative Study in Parallel Groups of Pharmacokinetics, Pharmacodynamics, Immunogenicity and Safety of Genolair As Solution and Lyophilisate Forms and Xolair® in A Solution Form PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase I an open-label randomized comparative study in parallel groups of pharmacokinetics, pharmacodynamics, immunogenicity, and safety of Genolair in two dosage forms (solution for subcutaneous administration and lyophilisate for the preparation of solution for subcutaneous administration) and Xolair® in healthy volunteers |
AO GENERIUM | 2023-01-15 |
| 416 | Vitamin C 4 Care Homes: A Pilot and Feasibility Study to Assess Daily Vitamin C Requirement of Care Home Residents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Older people in care homes are one of the most vulnerable groups with respect to risk, morbidity and mortality of severe coronavirus disease-2019 (COVID-19). In the UK, almost half (47%) of all COVID-19 deaths occurred in care homes. The World Health Organization (WHO) has highlighted vitamin C as an adjunctive therapy with biological plausibility for people with severe COVID-19. Previous research has indicated that up to 40% of care home residents in the UK are deficient in vitamin C, … |
PHYO KYAW MYINT; | 2023-01-15 |
| 417 | Efficacy of Ectoin® Inhalation Solution EIL07 As Supportive Treatment for Children and Adult With Mild to Moderate Asthma: A Post-Market Clinical Follow-up (PMCF) Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this multi-centre, prospective, open-label, single-arm, post-market clinical follow-up study is to further strengthen the already existing clinical evidence for supportive treatment and symptoms alleviation in asthma by evaluating the clinical efficacy of Ectoin® Inhalation Solution in paediatric and adults patients with mild to moderate asthma. |
ANDRZEJ EMERYK; | 2023-01-13 |
| 418 | A Phase III, Randomized, Multicenter, Parallel-group Clinical Trial for Examining The Therapeutic Equivalence Between Fluticasone Propionate 100 Mcg and Salmeterol 50 Mcg Inhalation Powder/Respirent Pharmaceuticals Vs. ADVAIR DISKUS® 100/50 Mcg Inhalation Powder/GSK in Patients With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Τherapeutic equivalence, randomized, multiple-dose, placebo-controlled, observer-blind, parallel group design consisting of a 2-week run-in period followed by a 4-week treatment period with Fluticasone propionate 100 mcg and Salmeterol 50 mcg inhalation powder/Respirent Pharmaceuticals (Test) or ADVAIR DISKUS® 100/50 mcg (Reference) or placebo. |
KONSTANTINOS KOSTIKAS; | 2023-01-10 |
| 419 | A Trial Evaluating Novel Technologies for The Diagnosis of Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial aims to evaluate novel diagnostic technologies for asthma in 3 different pathways providing the necessary evidence-base to allow adoption into clinical practice: – Pathway 1 evaluates whether the technology can distinguish between people with asthma and healthy volunteers, and other respiratory conditions in a well characterised secondary-care population and whether the parameters they measure correlate with the current standard diagnostic tests; – Pathway 2 assesses whether the technology can accurately diagnose asthma (either independently or alongside current diagnostic tests) in a primary care population of patients where there is a clinical suspicion of asthma; – … |
THOMAS DR BROWN; | 2023-01-09 |
| 420 | Juniperus Oxycedrus and Cupressus Arizonica Allergen Extracts. Determination of The in Vivo Allergenic Potency in Histamine Equivalent Units (HEP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine the biological activity of Juniperus oxycedrus and Cupressus arizonica. allergen extracts in histamine equivalent prick (HEP) units, in order to be used as in-house reference preparation (IHRP). |
JAVIER SUBIZA; | 2023-01-02 |
| 421 | The Effect of Mobile Application Game Training Designed for Children With Asthma on Asthma Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research is to examine the effect of mobile application game training designed for children aged 8-16 years on asthma management and quality of life. The population of the study will be children in the 8-12 age group who applied to the Mersin Pediatric Allergy, Asthma and Immunology Specialist’s clinic, and the sample will consist of 78 children with asthma who meet the criteria for inclusion in the research. This age group has problems in solving abstract problems, it is necessary to embody it in order to facilitate the understanding of the disease process. Therefore, … |
ATIYE KARAKUL; | 2023-01-02 |
| 422 | Effect of A Mobile App on Improving Asthma Control in Adolescents and Adults With Persistent Asthma: A Pilot Randomized Multicentre, Superiority Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: mINSPIRERS_RCT aims to assess the magnitude of the effect of a mobile app for improving asthma control in adolescents and adults with persistent asthma, followed at primary and secondary care in Portugal. |
JOÃO ALMEIDA FONSECA; | 2023-01-01 |
| 423 | Effect of Azithromycin With ICS/LABA in Non-eosinophilic Chest Tightness Variant Asthma: A Multicentre Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchial asthma (abbr. asthma) is one of common airway chronic inflammatory disease which usually threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually happened at night or in early morning. However, there are still some patients who persist only clinical manifestations of chest tightness, namely, chest tightness variant asthma (CTVA). This subgroup of asthma usually lacks asthma-specific clinical features, therefore, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2023-01-01 |
| 424 | BREATHE: An Efficacy-implementation Trial of A Brief Shared Decision Making Intervention Among Black Adults With Uncontrolled Asthma in Federally Qualified Health Centers (Trial and Post-trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an efficacy-implementation trial to: 1. evaluate systematically the efficacy of BREATHE in 200 Black adults receiving care at urban federally qualified health centers (FQHCs) for uncontrolled asthma; and 2. identify multi-level barriers and facilitators to the widespread adoption and implementation of BREATHE in FQHCs. |
MAUREEN GEORGE; | 2023-01-01 |
| 425 | Determinants of Functional Capacity in Children With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this study is to compare the respiratory function, respiratory muscle strength, functional capacity, and lower extremity strength of children with asthma and healthy children in the same age group. The secondary aim of our study is to determine the determinants of functional capacity in children with asthma. |
ATLAS UNIVERSITY | 2023-01-01 |
| 426 | Characterization and Definition of Right Ventricular Injury in Patients Admitted to Intensive Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The adequate characterization of RV injury is currently unknown. The hypothesis is that the best characterization of RV injury is the one with the most significant impact on the response to fluids and on the outcome. An RV failure is expected to induce fluid-unresponsiveness and potentially worst outcome. The main objective is to characterize different types of RV injury in critically ill patients by examining their association, including predictive performances, in hemodynamics parameters, ventilation parameters, and clinical outcomes The study will be based on the realisation of an echocardiography within 48 hours following inclusion. |
ANTOINE VIEILLARD-BARON; | 2023-01-01 |
| 427 | A Randomized, Open-labeled, Multicenter Clinical Trial to Compare The Efficacy and Safety of On-demand and Continuous Administration of Nasal Spray in The Treatment of Moderate-to-severe Persistent Allergic Rhinitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: WHO recommend to divide AR into 4 subgroups according to the symptom frequency (intermittent or persistent) and severity (mild or moderate-to-severe). For the persistent moderate-to-severe AR subgroup, the guideline suggests to treat with intranasal corticosteroid (INS) plus antihistamines (AH1) for 2-4 weeks. If the symptom is controlled then degrade the treatment (usually with INS) and maintenance for more than 4 weeks. However, up to 70% of patients suffering from AR do not follow treatment recommendation, they stopped medication when they feel better. This behavior always leads to uncontrolled AR, … |
ZHENG LIU ENT; | 2023-01-01 |
| 428 | Study of Mild and Moderate Asthma Step-up in Real Life As A New Endpoint (SURFE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the frequency needed for stepping-up treatment in patients with mild and moderate bronchial asthma. The main questions this study aims to answer are: – What is the frequency and duration in which patients of asthma need to step up their treatment? – … |
HESHAM RAAFAT; | 2023-01-01 |
| 429 | The Efficacy and Mechanisms of Action of N-3 Poly-unsaturated Fatty Acid Supplementation in People With Non-steroidal Exacerbated Airways Disease and Uncontrolled Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a syndrome compromising many phenotypes including N-ERD (caused by increased 4-series leukotriene (LT) production). n-3 PUFA supplementation modulates 4-series LT and has anti-inflammatory effects. However, other than in a pilot study with dietary manipulation, the effects of N-ERD are unknown. The primary objective is to determine whether n-3 PUFA supplementation in people with N-ERD can improve asthma control using the asthma control questionnaire (ACQ-7). This is a placebo controlled randomised controlled parallel multicentre study with of 6g per day of PUFA for 6 months in people with N-ERD and poor asthma control |
ANDREW WILSON; | 2023-01-01 |
| 430 | Contextualizing Asthma Self-Management With Measures of Indoor Air Quality for Black Adults With Uncontrolled Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aims of this project are twofold: 1. to characterize indoor air quality components obtained from apartments with gas stoves and open kitchens in a cohort of Black adults with uncontrolled asthma recruited from federally qualified health centers and enrolled in the parent study. 2. to conduct a comprehensive assessment of feasibility, implementation, and acceptability of the study. |
MAUREEN GEORGE; | 2023-01-01 |
| 431 | EAMS: The Electronic Asthma Management System PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an extension of a pilot study in which investigators developed and tested a computerized tool to help physicians to determine if their patients’ asthma is well controlled, advise them on medication changes required according to the current level of control, and automatically generate an electronic version of the AAP, all based on patient responses to a questionnaire completed by patients on a tablet computer. In this phase patients will have the ability to complete the questionnaire on their smartphones, through a pre-downloaded app and will have access to an electronic asthma self-management app. |
UNITY HEALTH TORONTO | 2023-01-01 |
| 432 | Influence of Nasal High-flow Therapy (NHFT) on Ventilation and Sympathetic Drive in Patients With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen University Hospital). Overactivity of the sympathetic nerve activity (SNA) axis with centrally increased heart rate and peripheral vasoconstriction is a known phenomenon in patients with systolic heart failure (HF) and has recently been described in patients with primary lung diseases as in chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH). Comprehensive studies investigating sympathetic drive in Asthma as one of the major pulmonary diseases are still lacking. Furthermore, … |
JENS SPIESSHOEFER; | 2023-01-01 |
| 433 | The Effect of Reflexology in Patients With Viral Bronchiolitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To test the influence of reflexology on bronchiolitis. |
EREZ NADIR; | 2023-01-01 |
| 434 | The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With The Standard Treatment Compared to Standard Treatment With Placebo PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study aiming to look in improvement of Pediatric Respiratory Assessment Measure (PRAM) score as a primary outcome. The secondary outcomes involving the need for second step management, need for admission and possible side effects. It’s double blinded randomized control study comparing Nebulized Epinephrine with standard treatment (salbutamol + Ipratropium) versus the standard treatment only in pediatric patient. A pilot study will be conducted before to detect the sample size required and data will be collected at deferent interval post treatment targeting intension to treat for analysis. |
ADNAN JUMA AL RAWAHI; | 2023-01-01 |
| 435 | Financial and Social Incentive-based Approaches to Improve Vaping Cessation Program Reach, Engagement, and Effectiveness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effectiveness of vaping cessation program consisting of media literacy education and real-time text messaging support and leverage insights from behavioral economics to enhance social and financial incentives to improve program reach, engagement, and eventually abstinence. The central hypothesis is that the behavioral economics informed intervention with social support and financial incentive would improve participant engagement and increase program effectiveness (i.e. vaping abstinence). |
TZEYU MICHAUD PHD; | 2023-01-01 |
| 436 | Role of Parasympathetic Activity in Mild to Moderate Asthma With Irreversible or Fixed Airflow Obstruction Received Fixed Dose ICS/LABA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In asthma, the major role of pathogenesis is chronic airway inflammation, bronchial hyperresponsiveness, and variable airflow obstruction, moreover, the autonomic nervous system also plays an important role in asthma, especially from the parasympathetic promoting bronchoconstriction and regulating airway inflammation and remodeling. Asthma with irreversible or fixed airflow obstruction (FAO) is a clinical phenotype. Although this condition frequently occurs in patients with severe asthma, there are pieces of evidence occurring in those with mild to moderate asthma. According to previous research, low lung function, FEV1 less than 60% predicted, … |
NARONGWIT NAKWAN; | 2023-01-01 |
| 437 | Comparative Analysis of ICS Combined with LABA Versus Addition of Omalizumab on Transcriptomic Expression Profiles in Patients with Allergic Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a chronic respiratory disease characterized by airway inflammation and obstruction, leading to wheezing, breathlessness, chest tightness, and coughing. Uncontrolled asthma impairs daily activities and reduces quality of life, making it a significant global health concern affecting 334 million people worldwide. Proper management is essential to minimize its impact. The Global Initiative for Asthma (GINA) recommends inhaled corticosteroids (ICS) combined with long-acting beta-agonists (LABA) as a cornerstone therapy for moderate to severe asthma, reducing inflammation and providing sustained bronchodilation. This combination improves symptom control and prevents exacerbations more effectively than ICS alone. For severe asthma inadequately controlled with ICS+LABA, … |
TAIPEI TZU CHI HOSPITAL BUDDHIST TZU CHI MEDICAL FOUNDATION | 2023-01-01 |
| 438 | The Effect of Manual Therapy Techniques on The Mobility of The Diaphragm in People With Asthma: Protocol for A Randomized Controlled Trial Related Papers Related Patents Related Grants Related Experts View Highlight: The mechanical alterations related to the overload of respiratory muscles observed in people with persistent asthma can lead to the development of musculoskeletal dysfunctions. Moreover, the produced lung hyperinflation and high lung volumes in the asthma crisis put the diaphragm at a disadvantage in terms of its length-tension curve and lowered its excursion and capacity to generate force. According to a preliminary study, … |
DIMITRIOS TSIMOURIS; | 2023-01-01 |
| 439 | INFLUENCEF STUDY: Epidemiology, Risk Factors and Clinical Phenotype of Headache Associated With Influenza Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational analytic study with a cohort desing is to evaluate the epidemiology, risk factors and clinical phenotype of headache during Influenza infection. The study will be done in collaboration with the Healthcare Sentinel Network of Castile and Leon (Red Centinela Sanitaria de Castilla y León, RCSCYL) and the National Influenza Center of Valladolid (CNGV). First, the historical data of the VIGIRA network of the 2010-2022 flu seasons will be analyzed, assessing the epidemiology and risk factors of headache during Influenza infection; and second, … |
DAVID GARCÍA AZORÍN; | 2022-12-20 |
| 440 | Asthma Control in Severe Asthma Patients Treated With Tezepelumab: A Prospective, Observational, Real-World Evidence Study (ASCENT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A study involving primary data collection within real-world settings of participants who initiate treatment with tezepelumab for severe uncontrolled asthma. This study will complement evidence obtained from randomized controlled trials and provide new data focusing on the holistic and patient reported outcome (PRO). |
ASTRAZENECA | 2022-12-13 |
| 441 | The Effect of Demonstration and Video Viewing Education on Metered Dose Inhaler Usage Skills in Asthma Patients: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the treatment of respiratory diseases such as COPD and asthma, bronchodilators and steroids, which are essential drugs, are preferred to be administered by inhalation compared to oral and parenteral routes. In the studies conducted with the use of inhaler drugs, it is seen that many wrong practices have been made regarding the techniques of using the inhaler drugs and that the correct usage techniques are not followed. Inability to use the inhaler device fully and correctly; It causes consequences such as failure to control the disease, increase in drug use and side effects, increase in exacerbations, … |
YASEMIN SAZAK; | 2022-12-12 |
| 442 | Effects of Sugammadex and Conventional Reversal on Lung Function in Laparoscopic Abdominal Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clincal trial is to determine the differences in few parameter of lung function (ie Forced Vital Capacity (FCV)) between Sugammadex and conventional reversal in laparoscopic abdominal surgery. The main questions it aims to answer are: 1. Is there differences in the pulmonary function test preoperative and post extubation between Sugammadex and conventional reversal in laparoscopic abdominal surgery? 2. Is there differences in the size of atelectasis area between Sugammadex and conventional reversal in laparoscopic abdominal surgery? 3. Is there differences between sugammadex and conventional reversal in postoperative mean length of stay in laparoscopic abdominal surgery? Participants will be asked 1. to do baseline spirometry before operation 2. to be examined for lung ultrasound before operation 3. to be given either sugammadex or neostigmine as reversal after operation is completed 4. to repeat spirometry after operation for few times 5. to be examined for lung ultrasound after operation Researcher will compare sugammadex group and conventional group to see if any difference in term of lung function, size of atelectasis and length of stay. |
RHENDRA HARDY MOHAMAD ZAINI; | 2022-12-07 |
| 443 | The Effect of Intranasal Dexmedetomidine Premedication in Children Undergoing Adenotonsillectomy Suffering From Recent Mild Upper Respiratory Tract Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to detect the efficacy of intranasal dexmedetomidine as a premedication to general anesthesia in pediatric patients with respiratory comorbidities undergoing adenotonsillectomy. |
EMAN AHMED AZZAM; | 2022-12-06 |
| 444 | Clinical Relevance of Small Airways Disease in Severe Asthma Patients Treated With Anti-InterLeukin-5 Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research is to investigate the extent and clinical relevance of small airways disease in severe eosinophilic asthma patients treated with anti-IL5/5R therapy. |
MEDICAL CENTRE LEEUWARDEN | 2022-12-02 |
| 445 | Observation on The Efficacy of Sublingual Immunotherapy With Dust Mite Allergen for Perennial Allergic Rhinitis and The Mechanism of Action on ILCs With ILC1s and ILC2s and ILC3s PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Allergic rhinitis is a common and recurrent ear, nose and throat (ENT) disease. It is a chronic or seasonal condition affecting 10% to 20% of the world’s population. It is considered one of the most difficult diseases to treat globally and has become a major global health problem. SUblingual immunotherapy (SIT) is currently considered to be an effective pairings therapy that can alter the natural progression of allergic rhinitis through immunomodulatory mechanisms. Immunotherapy is more suitable for patients with moderate to severe intermittent or persistent allergic rhinitis, … |
GUANGJUN TANG; | 2022-12-01 |
| 446 | Respiratory Impacts of Tailpipe and Non-tailpipe Particulates on Adults With Asthma: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to explore the health impacts of exposure to nontailpipe vehicle air pollution. The main question it aims to answer is: Does short term exposure to increased non-tailpipe course mode PM induce negative respiratory responses in adults living with asthma? We will recruit 48 non-smoking adults with mild-moderate asthma. Participants will be recruited from central and east London Participants will be exposed to three contrasting air quality environments, in field laboratories at the following locations: 1. High-speed continuous traffic location, … |
JAMES SCALES; | 2022-12-01 |
| 447 | Patient-Reported OUTcomes of Benralizumab in Real-World Use in Severe EosiNophilic Asthma Patients Multicountry, Multicenter, Observational, Prospective, Primary Data, Real-world Settings PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to generate real-world data on the characteristics of patients receiving benralizumab to assess early PRO parameters as well as long-term treatment effects in the Gulf cooperative council (Kingdom of Saudi Arabia, Kuwait, United Arab Emirates, Oman, and Qatar), Latin America (Brazil, Argentina, and Colombia), and India. It is anticipated that the data generated will provide practical, patient-focused real-world evidence and enhance communications between patients and physicians in an objective and structured manner to ensure better disease control in patients under benralizumab treatment. |
ASTRAZENECA | 2022-11-30 |
| 448 | Early Treatment of Heart Failure: A Non-interventional Observational Study of Patients With Heart Failure and Initiated on Dapagliflozin in Portugal PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure (HF) is a global, public health issue that affects more than 63 million people worldwide; this burden is expected to increase substantially as the population ages. Despite advancements in treatment, a HF diagnosis still leads to significant morbidity and mortality; there is also an immense impact on patients’ health-related quality of life (HRQoL). On May 5, 2020, the US Food and Drug Administration (FDA) announced the approval of dapagliflozin for heart failure with reduced ejection fraction (HFrEF), regardless of whether the patient has diabetes. Subsequently, … |
ASTRAZENECA | 2022-11-28 |
| 449 | Clinical Response of Nuberol Forte in Chronic Neck Pain in Routine Rehabilitation Centers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Globally, the prevalence of neck pain ranges from 16.7% to 75.1%. Despite conducting multiple studies on specific subject pools in Pakistan, primarily focusing on professional-related neck pain, there is a lack of accurate data to determine the local prevalence of neck pain or the effective management of neck pain through physical therapy and pharmacological intervention. The purpose of this study is to evaluate the clinical effectiveness of paracetamol and orphenadrine (Nuberol Forte) when combined with physical therapy in Pakistani patients suffering from neck pain at regular rehabilitation centers. |
ZAHOOR AHMED; | 2022-11-25 |
| 450 | Home Monitoring and Molecular Phenotyping of Patients With Post-COVID With Focus on Lung Involvement PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-acute COVID syndrome (PACS) /post-acute sequale of COVID-19 (PASC) / post-COVID is a novel clinical syndrome with unknown biological mechanisms, and to date no standard-of-care, routines for follow-up, or evidence-based treatments have been established. In this project, we will employ a systems medicine approach to identify pathways and networks of genes, proteins and metabolites that are critical in disease onset and progression, towards the goal of understanding specific mechanisms in the etiology of PASC. The objective of the project is to perform clinical and molecular characterization and sub-phenotyping of patients with PASC, (a.k.a. PACS, or post-COVID), into mechanistically relevant groups, … |
ASA WHEELOCK; | 2022-11-21 |
| 451 | Innovative Healthcare Delivery for Patients With Asthma By Means of Digitally Supported Self-management: A Pilot Study in Secondary Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the Netherlands, more than 600 thousand people have asthma. About half of these people have insufficient asthma control. This has a negative effect on their health and use of care. Insufficient knowledge about asthma and proper medication use, low self-confidence in managing asthma, and low compliance contribute to this problem. AstmaKompas is an eHealth application for asthma patients focused on self-monitoring and self-management. Astmakompas also connects patients with their healthcare professionals, among other things by giving healthcare professionals more insight into their patients’ disease progression, enabling them to provide timely(er) support. In this study, … |
JISKA AARDOOM; | 2022-11-21 |
| 452 | Optimising Inhaler Technique and Asthma Self-management in Children and Young People PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomised pilot study is to explore ways to optimise a care pathway that results in children and young people with asthma being better trained in the basics of asthma care and better able to apply self-management at the earliest possible stage. This will involve comparing a novel augmented teaching method (Video directly observed therapy (v-DOT)) with standard training in achieving and sustaining mastery of inhaler and nasal spray technique and the understanding of a personalised asthma action plan (PAAP). |
DARA O’DONOGHUE; | 2022-11-17 |
| 453 | Does Severity of Airflow Obstruction Correlate to Static Lung Volumes Obtained By Nitrogen Washout and Body Plethysmography? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Obstructive lung disease is defined by limitations in expiratory airflow, caused by excess mucus, loss of muscle tone, and structural changes. Over time airflow reduction can lead to gas trapping in the lungs (hyperinflation). Hyperinflation is linked to diminished exercise tolerance, shortness of breath, and a poor quality of life. Early treatment options include inhalers and pulmonary rehabilitation; however, surgical intervention and oxygen therapy may be required in the later stages. More prompt, accurate diagnosis will help to improve patient outcomes and optimise their treatment pathways. Two methodologies used to determine lung volumes and hyperinflation, … |
VIRGINIA HAWKINS; | 2022-11-15 |
| 454 | Mepolizumab Pharmacokinetics Among Patients With Severe Asthma: Protocol for A Case Control Study Comparing Clinical Responders Versus Non Responders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a chronic disease characterized by inflammation and obstruction of the airways. Identification of the mechanisms of action of corticosteroids has made it possible to define the type 2 inflammation present in nearly 80% of patients with asthma. Monoclonal antibodies (MAb) in severe asthma target type-2 inflammation. Mepolizumab is a humanized IgG1 (immunoglobulin gamma-1) kappa subclass monoclonal antibody directed specifically against interleukin 5 (IL-5). It acts specifically on eosinophil homeostasis, … |
ENGI AHMED; | 2022-11-15 |
| 455 | Evaluation of Virtual Reality Glasses Use During Inhaler Treatment in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Virtual reality (VR) glasses are technological devices that are often used in medical fields recently and are seen as suitable for distracting children. In the last few years, many studies have been conducted to facilitate pediatric patients against painful or frightening medical procedures. For uncomfortable procedures, distracting the child’s attention is seen as the most important point. VR technology has been used for procedures such as burn cases, tooth extraction, intramuscular injection, intravenous cannula, lumbar puncture, … |
BERKER OKAY; | 2022-11-10 |
| 456 | Phase II/III Parallel, Double-blind, Non-inferiority Study With Active Control, to Evaluate The Immunogenicity and Safety of A Booster Immunization Scheme With A Single Intramuscular Dose of The Recombinant Vaccine Against SARS-CoV-2 PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II/III parallel, double-blind, active-controlled, non-inferiority study to evaluate immunogenicity and safety of a booster immunization scheme of a single intramuscular dose of the recombinant vaccine against SARS-CoV-2 (AVX/COVID-12 vaccine) based on live recombinant Newcastle disease virus (rNDV) vector in healthy adults with a history of vaccination against COVID-19. The study is divided into two phases with immuno-bridging and 3000 healthy subjects showing evidence of prior immunity to SARS-CoV-2 are estimated to enrol. To verify non-inferiority in a determined number of subjects an intramuscular dose of the COVID-19 vaccine (ChAdOx-1-S[recombinant]) shall be used as active control in originally randomised subjects. The study shall be carried out in several sites of clinical research in Mexico. |
LABORATORIO AVI MEX S A DE C V | 2022-11-09 |
| 457 | Eosinophil Associated Proteins and Microbiome Profiling in Adults With Eosinophilic Oesophagitis at A Single UK Tertiary Centre PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Eosinophilic oesophagitis (EoE) is an inflammatory condition of the oesophagus (food pipe) that can lead to difficulty swallowing and to food to getting stuck and has become increasingly common over the past 40 years. EoE is triggered by a protein in the diet but alterations to the types of bacteria (microbiome) in the oesophagus may also be involved. EoE is diagnosed with gastroscopy (a thin camera test via the mouth) where 6 tiny samples (biopsies) are taken. Treatment is either with removing food groups from the diet or medications including steroids (budesonide) or a proton pump inhibitor (PPI, … |
ST GEORGE’S UNIVERSITY OF LONDON | 2022-11-09 |
| 458 | A Two-arm, Placebo-controlled, Randomized Clinical Trial to Evaluate The Effect of Tezepelumab on Airway Structure and Function in Patients With Uncontrolled Moderate-to-severe Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In adult patients with uncontrolled moderate-to-severe asthma, blocking TSLP with tezepelumab will improve ventilation heterogeneity (evaluated by hyperpolarized 129Xe MRI), and this will be associated with reduced airway inflammation (evaluated by sputum composition), luminal narrowing and plugging (evaluated by CT). |
PARAMESWARAN NAIR; | 2022-11-08 |
| 459 | Bronchiolitis Recovery and The Use of High Efficiency Particulate Air (HEPA) Filters PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, parallel, double-blind, randomized controlled clinical trial. Children \<12 months of age hospitalized with bronchiolitis are randomized 1:1 to receive a 24-week home intervention with filtration units containing HEPA and carbon filters (in the child's sleep space and a common room) to improve indoor air quality (IAQ) or to a control group with filtration units without HEPA and carbon filters. The HEPA intervention units and control units will be used for 24 weeks after pre-intervention IAQ measurements. Children are followed for respiratory outcomes over the pre-intervention and intervention periods. |
IDEA STATES PEDIATRIC CLINICAL TRIALS NETWORK | 2022-11-07 |
| 460 | Novel Treatment of Adrenal Crisis: An Early Clinical Trial With Nebulized Prednisolone PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: An adrenal crisis is an acute life-threatening event which may occur in patients with adrenal insufficiency. The initial emergency treatment consists of an intramuscular injection with 100 mg hydrocortisone administered by the patient or a bystander. The injection should be administered immediately. Although it is considered life-saving, it is not very patient-friendly, because of the several steps required for reconstitution, the intramuscular injection, the frequent presence of needle phobia, … |
UNIVERSITY MEDICAL CENTER GRONINGEN | 2022-11-03 |
| 461 | Next-generation Effects of Vitamin D Supplementation in Pregnancy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Vitamin D deficiency is common among pregnant women, despite daily vitamin D supplements. This study aims to investigate if maternal vitamin D intake of 90 vs 10 µg affects the overall health, growth, and immune system of the offspring at birth and after 1 year. Blood samples at birth and after one year, questionnaires and clinical 1-year examination will be performed on the children. |
PINAR BOR; | 2022-11-01 |
| 462 | Interventional Pilot Study to Evaluate The Effect of A Resveratrol-based Nasal Spray Associated With Carboxymethylbetaglucan in Isotonic Solution in The Prevention of RTI in Children With Pre-school Wheezing PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine whether or not preventive administration of resveratrol in the form of a nasal spray is effective in reducing the number of asthma exacerbations typical of preschool wheezing children who develop viral infections. |
MICHELE MIRAGLIA DEL GIUDICE; | 2022-11-01 |
| 463 | RIsk Factors, Diagnosis, and Management of SEvere/Uncontrolled Asthma From General Population to Clinical Setting: Update and Follow-up of The RItA Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Within the AGAVE project (2010-2014), funded by the 2008 AIFA (Italian Medicines Agency) Call (contract No. FARM8YRYZC), a severe/uncontrolled asthma online Registry (RItA) was implemented to assess the appropriateness of therapeutic strategies for severe/uncontrolled asthma patients, according to GINA (Global Initiative for Asthma) guidelines, in epidemiological and clinical samples. The online RItA Registry is a database containing information on patients’ general characteristics, medical history, clinical data, risk factors, comorbidity, asthma exacerbations, current asthma treatment. Currently, it contains information on severe/uncontrolled asthma subjects, enrolled at national level, … |
LAURA CARROZZI; | 2022-11-01 |
| 464 | The Impact of Pulmonary Rehabilitation on Respiratory Function and Quality of Life in Pediatric Patients With Chronic Lung Diseases: A Multidisciplinary Approach in Damietta Governorate PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic lung diseases (CLDs) such as asthma, cystic fibrosis, and bronchopulmonary dysplasia significantly impact pediatric patients’ respiratory function and overall well-being. Pulmonary rehabilitation (PR) has been shown to improve lung function, exercise tolerance, and quality of life in affected individuals. However, limited research has been conducted on PR implementation in Egypt. |
MOHAMED SALAH EL-SAYED; | 2022-11-01 |
| 465 | A Digital Respiratory Ecosystem for People Living With Asthma: Mixed Methods Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pilot study is to establish the feasibility and acceptability of a digital respiratory ecosystem (Breathe), that incorporates an acoustic adherence algorithm, asthma/COPD differentiation classification algorithm, a smart inhaler cap, a digital spirometer, and a real-time air quality database to support people living with asthma to better manage their disease and derive personal and clinical value. Through this study, 30 adults will be asked to use Breathe as a way to monitor and manage their asthma symptoms over a 12-week period. |
CHRISTOPHER LICSKAI; | 2022-11-01 |
| 466 | Investigation of The Effect of Yoga Training With Telerehabilitation on Asthma Control, Functional Capacity, Physical Fitness, Physical Activity and Quality of Life in Children With Asthma During The COVID-19 Pandemic Process PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In our study, yoga asana and pranayama practices, which will be applied by video call from computer or phone, will be advantageous in terms of time, transportation and access to asthmatic children whose anxiety and anxiety levels increase during the COVID-19 period, whose access to hospital services is difficult, and whose physical activity level decreases due to the increase in screen time. It was aimed to examine the effects of these group exercises on Asthma Control, Functional Capacity, Physical Fitness, Physical Activity and Quality of Life. In the randomized controlled study, … |
ŞEYMA NUR ÖNAL; | 2022-11-01 |
| 467 | Constant-load Versus Graded Aerobic Exercise for Promoting Cardiorespiratory Fitness and Functional Capacity in Obese Children With Bronchial Asthma: A Randomized Comparative Effectiveness Inquiry PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to compare the effect of constant-load aerobic exercise (CL-AE) and graded aerobic exercise (G-AE) on cardiopulmonary fitness, and functional capacity in a cohort of obese children with bronchial asthma (BA). A total of 78 children with BA were randomly assigned to the CL-AE group (n = 26, who underwent moderate-intensity aerobic training with the training load maintained at the same level throughout the entire program, besides the respiratory re-training program), the G-AE group (n = 26, received an intensity- and duration-graded aerobic training in addition to the respiratory re-training program), or the control group (n = 29, … |
RAGAB KAMAL ELNAGGAR; | 2022-10-30 |
| 468 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase II Clinical Study to Evaluate The Pharmacodynamic, Efficacy and Safety of Multiple Subcutaneous Injections of SHR-1703 in Asthma Patients With Eosinophil Phenotype PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the Pharmacodynamic, Efficacy and Safety of SHR-1703 in Asthma Patients with Eosinophil Phenotype. |
JIANGSU HENGRUI MEDICINE | 2022-10-30 |
| 469 | Nebulized Salbutamol Facilitate Management of Hyperkalemia Postreperfusion During Liver Transplantation: A Single-center, Randomized, Positive-controlled Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The therapeutic effect of nebulized salbutamol on hyperkalemia during reperfusion in liver transplantation patients. Secondary research objectives: To observe the results of blood gas analysis, changes in urinary potassium and hemodynamic parameters, and the incidence of reperfusion syndrome in liver transplantation, and to observe the incidence of postoperative pulmonary complications during the 7-day follow-up. To explore the effect of aerosol inhalation of salbutamol on new liver reperfusion syndrome in patients with liver transplantation, and to provide a theoretical basis for clinical treatment. |
JIAN WEN; | 2022-10-28 |
| 470 | Transition From Paediatric Intensive Care to General Paediatrics and Pneumology Units : A Study of The Post-intensive Care Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In developed countries, mortality rates in pediatric intensive care units (PICUs) are around 4% and most children admitted to these units survive. However, some pediatric survivors experience long-term morbidity (cognitive, … |
MICHAEL LEVY; | 2022-10-19 |
| 471 | Use of A Digital App to Deliver Home-based Rehabilitative Interventions in Patients Affected By Respiratory Diseases: A Monocentric Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the feasibility and the mid-term effects of a pulmonary rehabilitation intervention, delivered by digital App, on quality of life of patients affected by respiratory diseases. The App will include a monitored exercise training program based on most recent cardiopulmonary rehabilitation guidelines, including alerts, reminders and educational contents as well as chat and online visits with healthcare professionals to improve patient engagement. |
MICHELE VITACCA; | 2022-10-17 |
| 472 | Impact of A Personalized Case Management Program for The Follow-up of Moderate and Severe Asthma Patients on Exacerbations, Health Resource Use and Asthma Control: PERCASTHMA STUDY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to learn about the impact of the implementation of an intervention-based case management follow-up program during periods of clinical worsening or poor adherence in patients with moderate and severe asthma. Patients will be randomized into two arms: a case management follow-up group and a control group that will follow-up according to routine care practice. A single masking (outcomes assessor) was performed. Researchers will compare the response on exacerbations, health resource use and asthma control between the two groups during a one-year follow-up. Outcomes on pulmonary function, quality of life, adherence to treatment, … |
MANUEL CASTILLA MARTINEZ; | 2022-10-15 |
| 473 | Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age: A Point-of-care Testing Guided Randomized, Double-blind, Placebo-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the trial is to evaluate whether the use of oral prednisolone directed by point-of-care testing is useful in acute wheezing caused by rhinovirus in children aged 6-24 months. |
TERHI TAPIAINEN; | 2022-10-11 |
| 474 | Glucagon-Like Peptide-1 Receptor Agonist Treatment in Adult, Obesity-related, Symptomatic Asthma (GATA-3) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized placebo-controlled trial of semaglutide, an FDA-approved therapy for the treatment of type 2 diabetes mellitus and obesity, in adults with symptomatic asthma despite the use of inhaled steroids and with excess body weight. This study will test the central hypothesis that semaglutide will improve asthma control and reduce airway inflammation due to direct effects on the respiratory tract in adult asthma associated with obesity. |
KATHERINE CAHILL; | 2022-10-11 |
| 475 | BURAN: Effects of Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma Using Functional Respiratory Imaging Parameters PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the effects of benralizumab on airway dynamics in severe eosinophilic asthma in terms of quantitative computed tomography (CT)-derived measurements of pulmonary structure and function using the Functional Respiratory Imaging (FRI) platform. |
ASTRAZENECA | 2022-10-11 |
| 476 | ALPACA : The Effect of Online Monitoring and Communication on The Quality and Quantity of Pediatric Asthma Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The ALPACA study has a prospective randomized control interventional design, including a follow-up period to evaluate follow-up effects. The study is divided into two phases of 3 months using eHealth and observational monitoring. |
B.J. THIO; | 2022-10-07 |
| 477 | An Innovative Analytical Platform to Investigate The Effect and Toxicity of Micro and Nano Plastics Combined with Environmental Contaminants on The Risk of Allergic Disease in Preclinical and Clinical Studies PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Single-center, cross-sectional, longitudinal, observational, population based cohort study with stratified sample (by age group, gender, and residential area). |
MIRJANA TURKALJ; | 2022-10-05 |
| 478 | A 12 Week, Randomized, Double-blind, Multicenter, Active Controlled, 2-Arm Parallel Group Study Testing The Superiority of CHF 1535 PMDI 800/24µg Total Daily Dose (Fixed Combination of Extrafine Beclomethasone Dipropionate Plus Formoterol Fumarate) Compared to CHF 718 PMDI 800µg Total Daily Dose (Extrafine Beclomethasone Dipropionate) in Adults With Asthma on Medium or High-Dose Inhaled Corticosteroid PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the superiority of CHF 1535 compared to CHF 718 in subjects with asthma on medium or high dose inhaled corticosteroids. |
STEVEN F. WEINSTEIN; | 2022-10-05 |
| 479 | Efficacy of Esmolol Versus Magnesium Sulphate on Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: sixty patients, of both sexes, of ASA I or II planned for ambulatory laparoscopic cholecystectomy under general anaesthesia were engaged into 2 groups. Esmolol group were given 1 mg/kg loading dose followed by 30 μg/kg/min throughout the surgery, whereas magnesium sulphate (MgSo4) group were given loading dose 40 mg/kg over 15 mins then maintenance dose 15 mg/kg/h till end of surgery. General anaesthesia was standardized and postoperative analgesia included fentanyl. Variables denoting immediate recovery from anaesthesia, … |
ALEXANDRIA UNIVERSITY | 2022-10-05 |
| 480 | Study of The Effects on The Gut Microbiota in The Patients of Atopic Dermatitis Before and After The Treatment of Fucoidan PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Forty patients with physician-identified atopic dermatitis will be enrolled in the study. All patients must be aged between 6 and 60 years old. All patients consumed fucoidan for 3 months. |
YANG SIEN-HUNG; | 2022-10-04 |
| 481 | The Effect of Health Care Transition Based Education Program Given to Asthmatic Adolescents on Transition Readiness and Self-Efficacy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim: The purpose of this study was to examine the effect of health care transition-based education on transition readiness and self-efficacy in adolescents (14-18 years) with asthma through a randomized controlled experimental study that integrated the literature, model, and research on the transition from pediatrics to adult care. The research hypotheses are as follows: H0: There is no significant difference between the intervention and control groups’ mean Transition Readiness Assessment Questionnaire, … |
FATMA DİNÇ; | 2022-10-04 |
| 482 | Nasal Mucosal Immune Responses to Live Attenuated Influenza Virus (LAIV) in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Phenotypes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will determine the functional status of the nasal immune environment with LAIV exposure in COPD persons with frequent exacerbations (defined as individuals with two or more episodes of worsening in COPD symptoms requiring treatment with antibiotics and/or steroids in the prior 12 months) and COPD persons without frequent exacerbations to determine acute exacerbation of COPD (AECOPD)-associated dysfunction in a) cytokines and immune effector cells of the nasal mucosa and b) viral replication. The investigators hypothesize that: 1) COPD frequent exacerbators, compared to COPD infrequent exacerbators, will demonstrate altered mucosal immune responses to LAIV exposure, … |
MICHAEL B DRUMMOND; | 2022-10-03 |
| 483 | Uncontrolled and Possible Severe Asthma in Denmark – What Is The Magnitude of The Problem? PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma is a common, chronic disease with a high prevalence in children, adolescents and populations normally fit-to-work. Most asthma patients have a well-controlled disease and thereof a low usage of primary and secondary health care, as well as few sick days. With difficult-to-treat and severe asthma, a much higher health care and sick leave resource usage is seen. Previous studies show that only 1/3rd of patients prescribed high-dose, possibly side effect-laden, medications for difficult-to-treat or possible severe asthma have been seen by a specialist, … |
KJELL HÅKANSSON; | 2022-10-01 |
| 484 | A Novel Hygienic Maintenance Protocol for Implant Supported Hybrid Prosthesis. Prospective Clinical and Microbiological Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study we intend to carry out aims to analyze the clinical and microbiological effects of a new maintenance protocol for implant-supported hybrid prostheses. The maintenance protocol we propose is based on a sequence of phases that include not only the hygiene and cleaning of the prosthesis and the implants, but also the motivation and reinforcement of oral hygiene through iconographic aid (intraoral photographs of the patient). The proposed hygiene protocol is based on a meticulous preliminary plaque disclosure, followed by a full mouth decontamination of all intraoral mucosae, a decontamination of the secondary components, … |
NICOLA ALBERTO VALENTE; | 2022-10-01 |
| 485 | Incidence and Risk Factors of Postoperative Pulmonary Complications in Elderly Patients Undergoing Robot Assisted Laparoscopic Pelvic Surgery: A Single Center, Prospective, Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Postoperative pulmonary complications are important factors affecting the prognosis of patients undergoing surgery. Studies have shown that patients undergoing abdominal or pelvic surgery, emergency surgery, or prolonged surgery are more likely to develop PPCs, especially when robot-assisted laparoscopic surgery is performed at extreme head low. The incidence of PPCs and associated risk factors in patients undergoing robot-assisted laparoscopic surgery compared with those undergoing conventional surgery should be re-examined. |
FENG GAO; | 2022-10-01 |
| 486 | Interventional, Prospective, National, Multicentre, Randomised, Open-label, Controlled Clinical Study Comparing Two Parallel Groups, One Control Arm (Standard Treatment) Versus Intervention Arm (Standard Treatment + Study Product) Evaluating The Efficacy of Respicure® 0.38% /0.38% (Resveratrol / Quercetin) Phytotherapy Product From BEKER® Laboratories As An Add-on Treatment in The Management of Respiratory Conditions Including Asthma (Partially Controlled),Chronic Obstructive Pulmonary Disease COPD (Stage A, B, C and D) and Long Coronavirus Disease COVID in Algerian Adult Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Interventional, Prospective, National, Multicentre, Randomised, Open-label, Controlled Clinical Study Comparing Two Parallel Groups, One Control Arm (Standard Treatment) Versus Intervention Arm (Standard Treatment + Study Product) Evaluating the Efficacy of Respicure® 0.38% /0.38% (Resveratrol / Quercetin) Phytotherapy Product From BEKER Laboratories as an add-on Treatment in the Management of Respiratory Conditions Including Asthma (Partially Controlled),COPD (Stage A, B, C and D) and long COVID in Algerian Adult Patients . |
PR MERSAK GHARNAOUT; | 2022-10-01 |
| 487 | High-dose Vitamin D Supplement for The Prevention of Acute Asthma-like Symptoms in Preschool Children – A Double-blind, Randomized, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate whether high-dose vitamin D supplementation may have a beneficial effect on secondary prevention in preschool children (1-5 years of age), with respiratory infections being the primary cause of acute exacerbations with asthma-like symptoms. |
BO CHAWES; | 2022-10-01 |
| 488 | Evaluation The Effect of Ticagrelor and Clopidogrel in Stable Coronary Syndrome A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Elective PCI were included in the study. Patients were randomized into two different groups. One group took ASA 80 mg once daily and clopidogrel 75 mg once a day, and the other one took ASA 80 mg once a day and ticagrelor 90 mg twice a day. After six months of close follow-up, patients were asked to give a score to their dyspnea and asked about the major advance cardiovascular events ( MACE) |
JAVAD KOJURI; | 2022-10-01 |
| 489 | Pragmatic Study of The Effectiveness of Pharmaceutical Teleconsultation in Adults With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators propose a pragmatic randomized clinical study, consisting of two groups, the control group with health education and the intervention group with teleconsultation. The research team comprises pharmacists, students, and professors who work in a pharmaceutical service of secondary health care linked to the public university. The investigators will conduct the study exclusively remotely, following the patients for six months. The research team will implement and structure an ambiance to adapt the face-to-face pharmaceutical consultation into the pharmaceutical teleconsultation. The evaluated outcomes, in both groups, will be the scores of the Asthma Control Test, the Asthma Quality of Life, … |
STELLA PEGORARO ALVES ZARPELON; | 2022-10-01 |
| 490 | Feasibility of MHealth Technology for Improving Self-Management and Adherence Among Asthmatic Adolescents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of this project is to determine the feasibility, acceptability, and adherence of a smartphone application for improving asthma self-management in a pilot randomized controlled trial (RCT). The app is specifically designed to appeal to adolescents. Adolescents with persistent asthma will be randomized to receive: 1) standard-of-care or 2) the self-management app in addition to standard-of-care. Feasibility will be assessed by the ability to recruit and retain subjects, technical barriers to implementation, and the appropriateness of the intervention among adolescents and providers. The acceptability of the intervention will be determined by appraising perceived usefulness, entertainment, … |
AMY ALMAN; | 2022-10-01 |
| 491 | Preemptive Analgesia Combination of Celecoxib and Pregabalin in Total Hip Arthroplasty: Comparison of The Effects of Single Dose and Repeated Doses (Double-Blind Randomized Clinical Trial) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double-blinded randomized controlled trial aims to evaluate the effect of preemptive analgetic combination of celecoxib and pregabalin to acute pain after total hip arthroplasty. This study will be conducted in Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from October 2022 to April 2023. The subject of this study is adult patient who will be performed total hip arthroplasty. |
KEMAS MUHAMMAD AZKA NOVRIANDI; | 2022-10-01 |
| 492 | ProCare4Life Pilot 3 Clinical Study: Investigating ProCare4Life Impact on Quality of Life of Elderly Subjects With Neurodegenerative Diseases PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Personalized Integrated Care Promoting Quality of Life for Elderly People (ProCare4Life, PC4L) project was created to finalize a digital platform with integrated sensors , for monitoring the health status of the elderly subjects with neurodegenerative diseases and comorbidities. In fact, an integrated care platform – able to establish correlations between comorbidities, investigate the intake of different drugs, mitigate potential health risks, study the social variables and promote unified therapeutic procedures or social services – could help patients, caregivers, … |
ELDA JUDICA; | 2022-09-30 |
| 493 | ResQ Family: Impact of Respiratory Syncytial Virus (RSV) Hospitalisation on Quality of Life of Families – A Multi-Country Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Until today, there is only little information available on how severe RSV infection leading to hospitalisation of the infant impacts the quality of life of affected families. For the ResQ Family project, … |
JOHANNA KOSTENZER; | 2022-09-29 |
| 494 | Phenotyping and Classifying of Childhood and Adult Asthma Exacerbations: Towards Personalised Treatment. An Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: An observational study in patients between 12 and 70 years old with an acute asthma exacerbation, to determine the relation between phenotypical characteristics and the treatment response. |
GERT-JAN BRAUNSTAHL; | 2022-09-28 |
| 495 | ALTA – ALbuterol/Budesonide Treatment in Acute Airway Obstruction. A Randomized, Double-blind, 2-period, Cross-over Study Evaluating Efficacy and Safety of Repeated Doses of PT027 Compared to PT007 in Patients With Asthma and Acute Airway Obstruction Induced By Repeated Mannitol Challenges PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A study evaluating efficacy and safety of repeated doses of PT027 compared to PT007 in patients with asthma and acute airway obstruction induced by repeated mannitol challenges |
ASTRAZENECA | 2022-09-28 |
| 496 | A Single-centre, Observational, Prospective Study to Investigate The Effect of IL-13/IL-4 Blockade on Reducing Markers of Airway Autoimmunity in Severe Asthmatics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It has been observed that certain section of patients having severe to moderate Asthma, do not benefit from oral corticosteroids and IL-5 blocking biologics. There is increasing evidence that Airway auto immunity may be responsible for this poor response to treatment. It has been seen in earlier study done at Nair lab that these patients might benefit from Dupilumab, … |
MANALI MUKHERJEE; | 2022-09-28 |
| 497 | A Multicenter,Randomized,Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate The Efficacy and Safety of TQC2731 Injection in Patients With Poorly Controlled Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II, multicenter, double-blind, randomized, parallel group, placebo-controlled clinical study to evaluate the effect of three doses of TQC2731 on Annualized Asthma Exacerbation Rates(AAER) in adult subjects with poor control of severe asthma. It is estimated that 220 subjects will be included. The subjects will receive TQC2731 (70 mg Q4w, 210 mg Q4w, 420 mg Q4w) or placebo (Q4w) administered by Subcutaneous (SC) in the ratio of 1:1:1:1. The study comprised a 5 to 6-week screening period, a 52-week treatment period and a 12-week follow-up period. During the treatment period, … |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2022-09-23 |
| 498 | Nasal Allergen Challenge: Standardisation for House Dust Mite and Silver Birch Allergen Extracts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to establish dose-responses to nasal allergen challenge using silver birch pollen and house dust mite allergen extracts in participants with allergic rhinitis, sensitised to either or both of these allergens. The allergen extracts used will be Itulazax tablets (silver birch pollen allergen sublingual tablets, ALK-Abello, Denmark) and Acarizax tablets (house dust mite allergen sublingual tablets, ALK-Abello, Denmark). The results will allow identification of the dose of each allergen typically producing a moderate severity response, which could then be used in future, interventional and investigational studies. A control group – healthy individuals with no allergic rhinitis – … |
GUY SCADDING; | 2022-09-22 |
| 499 | Patient Education: Asthma and Pregnancy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pregnancy may impact treatment adherence in women with asthma. This is a major risk factor for asthma exacerbation, which may have an important impact for both women and the babies. This study aims to evaluate the impact of a targeted patient education action tailored for pregnant women with asthma. |
CHU DE REIMS | 2022-09-19 |
| 500 | Intravenous Magnesium: Prompt Use for Asthma in Children Treated in The Emergency Department PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many children currently being hospitalized with severe asthma could potentially avoid hospitalization and be sent home if their treatment in the emergency department was more effective. The investigators will conduct a pilot trial that will lead to a larger study to conclusively answer whether a simple and inexpensive medicine, intravenous magnesium sulfate, can be used in the emergency department to prevent hospitalization for these children. |
MIKE JOHNSON; | 2022-09-12 |