Clinical Digest: Recent Clinical Trials on Chronic Fatigue Syndrome
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Chronic Fatigue Syndrome. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Chronic Fatigue Syndrome
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial – Effect of Hyperbaric Oxygen Therapy for The Treatment of Post COVID Condition (RECLAIM-HBOT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The RECLAIM study platform will be used to explore whether the use of Hyperbaric Oxygen therapy (HBOT) improves the symptoms of post covid cognitive dysfunction. Hyperbaric oxygen therapy is a well-established medical treatment. HBOT promotes healing by delivering a high concentration of oxygen into the body. This high level of oxygen has a number of known benefits, such as growth of new blood vessels, as well as regulating immune and inflammation responses. It helps protect the brain and other nervous tissue from inflammation. HBOT may also have antiviral effects. Collectively, … |
RITA KATZNELSON; | 2025-05-01 |
| 2 | Mind-Body in Long COVID and Myalgic Encephalomyelitis Study (MILES): A Patient-Centred RCT PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC). Our team recognizes that ME/CFS and Long COVID are serious, debilitating, biomedical conditions. ME/CFS can affect many different parts of the body, such as the nervous system, immune system, and metabolism. It is hypothesized that central sensitization (i.e., when nerves get too excited) may influence these complex conditions and may make symptoms worse. This study explores a mind-body program called the Dynamic Neural Retraining System™, or DNRS™. Mind-body interventions (MBIs) focus on how the brain, mind, body, … |
UNIVERSITY OF ALBERTA | 2025-05-01 |
| 3 | A Phase II, Multi-centre Open Label Study to Assess The Efficacy and Safety of Oral Apabetalone With Background Dapagliflozin in Subjects With Long -COVID-19 (Post-COVID-19 Conditions) and Type 2 Diabetes Mellitus (T2DM) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label, multicentre, phase II clinical trial that aims to assess the efficacy and safety of oral Apabetalone with background dapagliflozin for up to 12 weeks in T2DM patients with a history of probable or confirmed SARS-CoV-2 infection, with symptoms within 3 months from the onset of COVID-19 that last for at least 2 months and cannot be explained by an alternative diagnosis. |
RESVERLOGIX | 2025-04-15 |
| 4 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of The Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The efficacy and safety of rituximab on ME/CFS symptoms after administration to patients with myalgic encephalomyelitis/chronic fatigue syndrome will be compared in an exploratory, placebo-controlled, double-blind fashion. In the subsequent secondary evaluation period, subjects who received rituximab in the primary evaluation period will receive placebo, and the timing and duration of rituximab’s effect will be explored throughout the entire evaluation period. Subjects who received placebo during the primary evaluation period will receive rituximab during the secondary evaluation period to explore changes in endpoints before and after switching from placebo to rituximab in the same subjects. |
TOMOKO OKAMOTO; | 2025-04-09 |
| 5 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial – Effect of Hi-OxSR for The Treatment of Post COVID Condition (RECLAIM-HiOxSR) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The RECLAIM study platform will be used to explore whether the use of the Hi-OxSR device improves the symptoms of post covid cognitive dysfunction. Carbon dioxide (CO2) has been proposed as a potential treatment for persistent immune activation as there is evidence that CO2 has antioxidant, anti-inflammatory, and anti-cytokine effects. We conducted a pilot study assessing the open label use of re-breathing CO2 (using Hi-OxSR) twice a day for 14 days, … |
ANGELA M CHEUNG; | 2025-04-01 |
| 6 | Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Long COVID is a complex condition that affects approximately 1.4 million Canadians following SARS-CoV-2 infection. Fatigue is the most common symptom of Long COVID. This feasibility trial will evaluate a new rehabilitation program called COVIDEx for treating fatigue after COVID-19, and compare its effectiveness to the standard treatment currently used. The experimental treatment group will receive an 8-week multi-modal rehabilitation program with two 50-minute sessions per week. 60 participants will be recruited, randomly assigned to the COVIDEx program or standard of care (SoC) and followed for 24 weeks. |
PAVLOS BOBOS; | 2025-04-01 |
| 7 | Development of A Regional Irritable Bowel Syndrome Cohort PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Setting up a regional (multicentre), longitudinal cohort of people suffering from irritable bowel syndrome followed up in consultation to study the natural history of the disease and its prognosis. |
UNIVERSITY HOSPITAL ROUEN | 2025-03-04 |
| 8 | Effectiveness of A Personalized In-home Telerehabilitation Program on Self-Care in Patients with Long COVID: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate whether a 12-week tele-rehabilitation programme with monitoring via a mobile app produces medium-term improvements in self-management, fatigue and quality of life in patients affected by persistent COVID. The main questions it aims to answer are: * Will a multimodal program (exercise with education) improve the self-management ability of patients with post-exertional malaise? * Does fatigue and quality of life will be improved in these patients? Researchers will compare an experimental breath program to a control standard care group to see if multimodal program works to treat post-exertion malaise. Participants will: * Follow-up 12 weeks online sessions: 1 weekly synchronous online session + 1 scheduled asynchronous session + educational resources * Daily use of the app: daily log, education and questions |
CEU SAN PABLO UNIVERSITY | 2025-03-01 |
| 9 | Characterization, Treatment, and Long-term Follow-up of Fatigued Patients in Primary Care PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The overarching purpose of this project is to further the understanding of fatigue as a symptom in primary care patients, and to build evidence for a highly accessible treatment targeting fatigue that can be readily implemented in primary care clinics. Data will be collected within a randomized controlled superiority trial (RCT; N = 500). The primary aim is to evaluate the effectiveness of a novel cognitive behavioral therapy (iFAS: Internet-delivered treatment of Fatigue Across Syndromes) for fatigued patients as compared to care as usual (CAU). Primary outcome will be change in fatigue severity (as measured by the Checklist Individual Strengths, … |
ELIN LINDSÄTER; | 2025-02-06 |
| 10 | STUDY TO EVALUATE THE ROLE OF T CELL-DYSFUNCTION IN SYMPTOMS ASSOCIATED WITH LONG COVID, LYME DISEASE AND MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME USING THE VIRAXIMMUNE FLUOROSPOT T CELL ASSAY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a longitudinal observational study recruiting individuals that have attended three clinical sites with symptoms associated with a diagnosis of long COVID, PTLDS or ME/CFS. The study will be a multi-centre study, with up to 160 male and female participants enrolled. Participants that experience symptoms considered to be associated with a diagnosis of long COVID, PTLDS or ME/CFS will consent to the study, and attend for two study visits (at study entry and 6 months) to complete a questionnaire related to their symptoms, … |
VIRAXBIO LABS | 2024-12-10 |
| 11 | Use of Transcutaneous Vagus Nerve Stimulation in Reducing The Symptoms of Long COVID Patients Who Fulfill Diagnostic Criteria for ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A prior open label study has shown that transcutaneous vagus nerve stimulation \[tVNS\] can improve the health of some patients with postacute sequelae of SARS-CoV-2 infection (PASC), severely affected enough to also fulfill criteria for myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). The purpose of this study is to compare two sets of stimulus parameters to determine the one that best improves the health-related quality of life of these patients over a period of 6-weeks. Patients using their assigned device for at least 30 of the 42 possible opportunities will receive the best device for an additional 6-week period. |
BENJAMIN NATELSON; | 2024-11-01 |
| 12 | Pilot Study on The Feasibility of An RCT: Evaluating Periodic Fasting As A Treatment Strategy for Long Covid in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Long COVID, characterized by persistent symptoms following acute COVID-19 infection, has emerged as a significant public health concern. Symptoms range from fatigue, cognitive impairments, to respiratory difficulties, affecting patients' quality of life. Dietary interventions, particularly fasting, have historically been used to modulate immune responses and improve health outcomes in various conditions. The Buchinger-Wilhelmi method represents a structured and medically supervised fasting approach. Given the inflammatory nature of long COVID, fasting may offer therapeutic benefits by modulating the immune response, enhancing cellular repair mechanisms, … |
JOCHEN SCHNEIDER; | 2024-10-15 |
| 13 | Effectiveness of Pain Neuroscience Education in Women With Menstrual Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Menstruation is the bleeding that starts with menarche and continues until menopause, along with hormonal changes in women of reproductive age, and is shed as the endometrium matures and is shed. Menstruation, which covers 30-35 years of a woman’s life and occurs regularly every month, … |
OSMAN COBAN; | 2024-10-01 |
| 14 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine if low-dose naltrexone (LDN) reduces fatigue, improves related symptoms, and reduces inflammatory markers in peripheral blood in cases with Post-COVID-19 Fatigue Syndrome (PCFS) from COVID-19 (i.e. confirmed SARS-CoV-2 case). LDN refers to naltrexone given in doses of 1-4.5 mg. Overall, studies have found that LDN is safe and well-tolerated. It may help to reduce pain and inflammation and improve well-being and immune function.The trial will be conducted by the Complex Chronic Diseases Program (CCDP) at BC Women’s Hospital and will demonstrate whether LDN could benefit a large number of people with PCFS. |
LUIS NACUL; | 2024-01-15 |
| 15 | Effect of Aerobic Training on Quality of Life in Elderly With Idiopathic Chronic Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the study was conducted to evaluate the effectiveness of aerobic training for decreasing fatigue severity and increasing quality of life in elderly with idiopathic chronic |
OLA MOHAMED ELSAYED ELGOHARY; | 2024-01-01 |
| 16 | Pilot Study of An Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate The Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Long Covid is a multisystem condition comprising often severe symptoms that follow a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Long COVID often manifests as fatigue and neurocognitive impairment (also referred to as ‘brain fog’). Based on two systematic reviews of Covid-19 cases in neonates, children and adolescents under 19 years of age, fatigue caused by Long Covid can persist for years and can lead to work disability and labour shortages, posing a public health emergency with lasting health, mental, and economic impacts. To date, … |
ZAMIR HUSSAIN SUHAG; | 2024-01-01 |
| 17 | Hydrogen Water Dosing Study for ME/CFS and Chronic Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this 16-week pilot randomized trial is to explore the potential benefit of the OTC supplement hydrogen water, for the symptoms of chronic fatigue syndrome (CFS). Methods: This 16-week home-based trial will compare two groups: (1) low dose hydrogen water (2-3 glasses/day) for all 16 weeks; … |
FRED FRIEDBERG; | 2023-12-01 |
| 18 | A Feasibility Study Assessing The Acceptability, Adherence, and Safety of Photobiomodulation (PBM) Therapy and Objective Assessment Measures in Myalgic Encephalomyelitis (ME) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is no cure or approved treatments for ME. Several causes have been implicated in ME, including poor mitochondrial function. Mitochondria are the powerhouse of cells, producing energy. Therefore, loss of mitochondrial function and reduced energy production could be an explanation for the debilitating chronic fatigue that defines ME. The primary site of red light absorption in cells is the mitochondria. Mitochondrial red light absorption can boost energy production. Light therapy is already FDA approved for the treatment of acne, muscle and joint pain, arthritis, … |
SIMON CARDING; | 2023-12-01 |
| 19 | Phase 2a, Double-blind, Randomized, Placebo-controlled Trial of Methylprednisolone Versus Placebo in Patients with Cognitive Deficits in Post-COVID-19 Syndrome (PCS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to learn about the therapeutic value of Methylprednisolone, a well-known immunosuppressant, on cognitive deficits in patients with post-COVID-19 syndrome (PCS). The main questions it aims to answer are: 1) Does Methylprednisolone improve memory function in PCS patients compared to placebo? 2) Does Methylprednisolone improve other patient centered outcomes in PCS patients such as fatigue, mood and quality of life compared to placebo? 3)What are the side effects of Methylprednisolone in this patient population, and how common are they? Participants in this study will be patients with PCS and cognitive deficits, … |
HEINRICH J AUDEBERT; | 2023-10-01 |
| 20 | An Alternative Approach to Fatigue and Comfort Levels in Hemodialysis Patients: Reiki Energy Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic renal failure (CRF) is a chronic and progressive kidney disease caused by impaired metabolic and endocrine functions as a result of a decrease in glomerular filtration rate (GFR), the role of the kidney in maintaining fluid electrolyte balance. KRG, which has high mortality and morbidity, is defined as an important public health problem due to the fact that it also causes a great burden on health systems. Reiki is not an alternative to allopathic medicine; … |
MERVE TOPAC; | 2023-10-01 |
| 21 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this study is to find out if rehabilitation exercise can help people who have long COVID. Participants will be randomized by chance to receive either aerobic exercise or breathing exercise (combined with stretches). Participants will be guided and supported in completing a tailored, 6-week home exercise program to be performed 5 – 6 days a week, prescribed and supervised by rehabilitation therapists. Participants will perform breathing exercises, which will be supervised by an occupational therapist. The focus of Aim 1 is to determine feasibility of implementing RESToRE in long COVID. |
ANNAMARIA R. NORWEG; | 2023-10-01 |
| 22 | Exploring Worry in The Context of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Qualitative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be building on the findings of Kalfas et al 2022 paper exploring the prevalence of generalised worry in patients with Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) before and after Cognitive Behavioural Therapy (CBT). The research was conducted in South London and Maudsley NHS Foundation Trust’s (SLaM) Persistent Physical Symptoms Research and Treatment Unit. Previous research has indicated a bidirectional relationship between fatigue and worry (Kalfas et al., 2022); … |
KING’S COLLEGE LONDON | 2023-10-01 |
| 23 | Observational Study of Hyperbaric High Pressure Oxygen Therapy (HBOT) in Patients with Post-COVID Syndrome (PCS) and Myalgic Encephalomyelitis/chronic Fatigue Syndrome (ME/CFS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this observational study is to document symptom progression in 60 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) who undergo Hyperbaric Oxygen Therapy (HBOT) following COVID or other infections. Participants will receive HBOT treatment as an additional option after completing the Chronic Fatigue Syndrome CARE (CFS_CARE) study and will be invited to take part in this observational study. Patients will complete health evaluations in the form of questionnaires, including the 36-Item Short Form Health Survey (SF-36), to assess changes in ME/CFS-related symptoms after HBOT. Rather than evaluating the efficacy of HBOT itself, … |
CARMEN SCHEIBENBOGEN; | 2023-07-15 |
| 24 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine The Effects of Oxaloacetate on Improving Fatigue in Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Following acute COVID-19, some patients develop a group of debilitating symptoms that include fatigue, orthostatic intolerance, difficulty with attention and concentration (often called brain fog), myalgias and disrupted sleep. The term Long COVID is used to describe these symptoms after the initial viral infection has passed. These symptoms are the same as those that define myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A Proof of Concept trial showed significant fatigue benefit in Long COVID patients. This randomized, … |
LUCINDA BATEMAN; | 2023-06-01 |
| 25 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The researchers propose to develop a Canada-wide, adaptive randomized clinical platform trial to assess the effectiveness of various interventions in patients with lingering symptoms of COVID-19 (Long COVID). Participants will be randomized initially to 1 of 3 arms, including placebo (control) and 2 interventions. Because this is an adaptive trial, … |
ANGELA M CHEUNG; | 2023-05-31 |
| 26 | Amygdala Insula Retraining in The Management of Long COVID Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to compare a mind body intervention against usual care in patients with fatigue with long COVID. Our research questions include 1. Is the mind body intervention additive to usual care in long COVID 2. Can the mind body intervention change laboratory markers, heart rate variability and dysautonomia. |
LEONARDO TAMARIZ; | 2023-05-15 |
| 27 | A Single-blinded Sham-controlled Crossover Trial to Evaluate The Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the efficiency and safety of immunoadsorption for the treatment of post-COVID syndrome (PCS). Efficacy will be measured (1) subjectively as an improvement of the score of questionnaires like the multidimensional fatigue inventory (MFI-20), Chalder fatigue scale, Bell-score, … |
JULIA WEINMANN-MENKE; | 2023-05-08 |
| 28 | Efficacy of Baduanjin Qigong Exercise Plus Selected Exercise Program on Chronic Fatigue Syndrome and Postural Imbalance Following Lower Limb Burn Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 90 patients who suffer from chronic fatigue syndrome and postural imbalance following Lower Limb Burn Injury. will be selected from outpatient clinic, faculty of physical therapy, Cairo university. Patients will be assigned randomly into 3 groups of equal numbers, group A: (Study group A) will receive Baduanjin Qigong exercise plus selected exercise program. group B:(Study group B) will receive Baduanjin Qigong exercise, Group C (control group C) will receive selected exercise program . |
KHADRA MOHAMED ALI; | 2023-04-30 |
| 29 | The Role of Epigenetic Mechanisms in Stress Intolerance in Patients With Chronic Widespread Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with chronic widespread pain (CWP) frequently experience stress intolerance – an exacerbation of symptoms in response to stress. Although it severely affects their quality of life, stress intolerance remains a mystery. Hence, unravelling the mechanisms underlying stress intolerance is crucial to understand CWP pathophysiology and to develop novel treatments. Epigenetic mechanisms hold the potential to provide an answer as they have been found to be altered in patients with CWP at baseline, and in response to stress. However, research on epigenetic mechanisms in CWP is very scarce. Hence, … |
JO NIJS; | 2023-04-19 |
| 30 | NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Gulf War illness (GWI) affects up to 210,000 U.S. veterans who served in the Middle East during the Gulf War in 1990-1991. Symptoms include fatigue, muscle and joint pain, forgetfulness, headaches, rashes, … |
BRIAN T WALITT; | 2023-04-16 |
| 31 | Connecting Breath and Mind: Development of An Online Holistic Treatment Programme Connecting Psychological Wellbeing and Breathing Techniques in Children and Young People With Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Recruitment target: Phase I: Co-design of intervention: 5 to 15 CYP aged between 12-18 years of age referred to the pan-London long COVID MDT. Phase II: Randomised pilot: 40 patients (12-18 years) will be recruited from a potential pool of 214 patients referred to the pan-London long COVID MDT. Methods: Phase I: Co-design Design and setting The intervention will be co-designed with CYP following a process informed by practice-base evidence, which centres the voices and wisdom of CYP, focuses on creativity and playfulness, … |
ROYAL BROMPTON & HAREFIELD NHS FOUNDATION TRUST | 2023-02-03 |
| 32 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericiguat Compared to Placebo Tablets in Male and Female Participants Aged 18-50 Years With Post-COVID-19 Syndrome Without (PCS) or With (PCS/CFS) Fulfillment of ME/CFS Criteria (VERI-LONG) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main questions it aims to answer are: • Does Vericiguat relieve fatigue and/or other symptoms associated with post-COVID-19 syndrome? • What are the side effects of Vericiguat in this patient population; and how common are they? Participants will be asked to participate for approx. 18 weeks. After screening, participants will receive assigned intervention of either 10 weeks of treatment with Vericiguat or matching placebo tablet, … |
JUDITH BELLMANN-STROBL; | 2023-02-01 |
| 33 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the effectiveness of repeated immunoadsorption intervention in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS). The main questions it aims to answer are: (1) Does repeated immunoadsorption relieve fatigue and/or other symptoms associated with CSF and PACS-CSF? (2) Is repeated immunoadsorption safe and tolerable in this patient population? What are the side effects of repeated immunoadsorption, and how common are they? Participants will be asked to participate for approx. 32 weeks (8 months). After screening, … |
SUSEN BUROCK; | 2023-02-01 |
| 34 | The COPE Study: Pilot Intervention to Improve Symptom Self-management and Coping in Adults With Post COVID PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project is a randomized controlled pilot trial using mixed methods to examine the feasibility, acceptability, and initial effects of a telemedicine group-based intervention designed to improve symptom management and coping in adults with Post-COVID. |
TRACY HERRING; | 2023-01-18 |
| 35 | Post-COVID-19 Chronic Fatigue Syndrome PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2. |
EMAD R ISSAK; | 2023-01-08 |
| 36 | Evaluating The Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to gather data and assess changes in patient-reported outcomes with the stellate ganglion blocks as treatment for their sympathetically-mediated long COVID symptoms. |
JONATHANN KUO; | 2023-01-03 |
| 37 | Enhanced External Counterpulsation (EECP/ECPT) to Treat Long-COVID-19 Fatigue – A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this double blind, outcome-assessor blind, randomized controlled trial, is to compare the effectiveness of external encounter counterpulsation (EECP) versus sham procedure in participants with long COVID-19 fatigue. The main question[s] it aims to answer are: – Whether EECP improves fatigue score – Whether EECP improves quality of life, six-minute walk test, and endothelial function Participants will attend 15 sessions (1-hour each) of EECP during 5 weeks Researchers will compare EECP versus sham procedure for the above outcomes. |
DAFNA YAHAV; | 2023-01-01 |
| 38 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to study the effects of stellate ganglion block (SGB) in participants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The main questions it aims to answer are: Does SGB treatment improve symptoms of ME/CFS (e.g. brain fog, fatigue)? Do changes in symptoms go along with changes in blood or saliva? Participants will receive a total of six blocks over three weeks (one block on each side, one day apart, per week). Prior to treatment and at two points following treatment, participants will complete surveys, take a cognitive (puzzle type) test, … |
DEBORAH L DURICKA; | 2023-01-01 |
| 39 | Effects of A Functional Re-education and Environmental Adaptation Programme on Levels of Dependency, Dyspnoea, Functional Capacity, Quality of Life and Caregiver Burden in Cancer Patients With Associated Respiratory Pathology PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the investigators propose an interdisciplinary intervention, carried out by occupational therapists, nurses, physiotherapists and doctors specialised in this type of patient, aimed at improving conventional clinical practice and implementing a programme of functional re-education and environmental adaptation that implements conventional clinical practice, and which the investigators also consider to be an essential intervention in the follow-up of patients with associated respiratory pathology once they are discharged from hospital. |
EDUARDO J FERNÁNDEZ RODRÍGUEZ; | 2023-01-01 |
| 40 | The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study aims to evaluate the use of i3.1 probiotic in participants who meet the Institute of Medicine (Canadian Consensus Criteria) case definition for ME/CFS and who may or may not be diagnosed with irritable bowel syndrome (IBS). The main questions it aims to answer are: * how effective is the usage of the i3.1 probiotic to reduce gastrointestinal (GI) inflammation and normalize the GI and systemic/brain interface? * how well is it working on IBS severity? The study sample is 100 male and female participants aged 45 to 70 years with ME/CFS (per the Canadian Consensus Criteria); … |
NANCY KLIMAS; | 2022-12-20 |
| 41 | In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To date, little is understood regarding post-COVID fatigue or cancer fatigue though it is known to affect a large proportion of patients (10-70% depending on the population). This study aims to investigate potential mitochondrial function and metabolic changes in brain to provide further information regarding the etiology of these changes leading to fatigue. This study hypothesized that Post-COVID fatigue is ensued by perturbations in metabolism and mitochondrial function in the brain. This is a case-control study. In this study, … |
JEONG HOON K LIM; | 2022-12-09 |
| 42 | EFFECTS OF VAGUS NERVE STIMULATION IN POST COVID-19 SYNDROME: A RANDOMIZED CONTROLLED TRIAL PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to increase parasympathetic activity and decrease the severity of symptoms by providing vagal stimulation with the t-VNS method in order to suppress the increased sympathetic activity in patients with prolonged Covid symptoms.The main question[s] it aims to answer are: Question 1:Is left ear transcutaneous vagus nerve stimulation effective in suppressing the symptoms of patients in Post Covid syndrome? Question 2:Is bilateral auricular transcutaneous vagus nerve stimulation effective in suppressing the symptoms of patients in Post Covid syndrome? A 5-minute heart rate variability measurement will be performed to measure the effectiveness of vagus nerve stimulation in participants.HRV is a non-invasive method used to evaluate ANS activity and is a measure of heart rate change over a period of time |
ALPER PERCIN; | 2022-10-27 |
| 43 | A Randomized, Placebo-controlled, Double-blind Crossover Study to Evaluate Efficacy of EnXtra on Accuracy & Reaction Time, Perceived Alertness & Digital Fatigue for Video Gamers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the present study, Sponsor aim to evaluate the effects of EnXtra® as to improve Accuracy & Reaction Time, Perceived Alertness & Digital Fatigue for Video Gamers. A Randomized, Placebo-controlled, Double-blind Crossover Study of 60 randomized cross over for total study duration of approximately 25 days with 5 days of treatment period for each arm and 5-7 days wash out period between both arms. |
SHALINI SRIVASTAVA; | 2022-10-10 |
| 44 | Effect of Intensive Combined Rehabilitation Therapy for Patients With Post COVID 19 Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effect of intensive combined rehabilitation therapy in form of Graded Exercise Therapy (GET) , Cognitive Behavioral Therapy (CBT) to treat patients with post COVID19 chronic fatigue syndrome . |
SAMAR HOSNY; | 2022-10-01 |
| 45 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: A Randomized, Double-blind, Placebo-controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate the effects of oral melatonin and zinc supplementation on core features in individuals with ME/CFS |
JOSÉ ALEGRE; | 2022-09-05 |
| 46 | Effectiveness of A 3-months Dietary Supplementation Based on Quercetin Phytosome®) for The Treatment of Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate whether a 3-month period of quercetin supplementation (500 mg of Quercetin Phytosome®) is useful in the treatment of chronic fatigue, as assessed by the Fatigue Impact Scale (FIS-40). Secondary end points are sleep assessment through Pittsburgh Sleep Quality Index (PSQI) and muscle performance assessment through the Short Physical Performance Battery (SPPB) and body composition assessment using DXA. |
AZIENDA DI SERVIZI ALLA PERSONA DI PAVIA | 2022-09-01 |
| 47 | Observational Study of Repeat Immunoadsorption (RIA) in Post Covid ME/CFS Patients with Elevated ß2 Adrenergic Receptor Autoantibodies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The evidence for an autoimmune etiology in postinfectious myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is growing. The investigators observed in a not yet published study that in ME/CFS triggered by COVID, similar to ME/CFS after other infections, there is a close correlation of ß2 adrenergic receptor (ß2R) autoantibodies with symptom severity. Immunoadsorption (IA) to remove autoantibodies has been used successfully in many autoantibody-mediated diseases. The investigators have already performed two proof of concept studies of IA in postinfectious ME/CFS with elevated ß2R antibodies, … |
CARMEN SCHEIBENBOGEN; | 2022-08-28 |
| 48 | Interoception in Patients With Medically Unexplained Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about interoception in patients with stress related syndromes (overstrain, burnout; SRS) and functional disorder (fibromyalgia/ chronic fatigue syndrome; FD). The main questions it aims to answer are: – Is there a significant difference in interoception between patients with SRS and healthy controls? – Is there a significant difference in interoception between patients with FD and healthy controls? – … |
INDRA RAMAKERS; | 2022-07-25 |
| 49 | Study to Determine The Effectiveness of Therapy Methods (Acceptance Commitment Therapy, Micro Breaks) in Patients With Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a distinct disease entity with an estimated prevalence of 0.3-0.7% and more common in women (3:1 ratio). It can be diagnosed according to the Institute of Medicine (IOM) 2015 consensus definition using 3 major criteria and one of 2 minor criteria. Diagnosis requires that the patient have the following three symptoms: 1. A substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities that persists for more than 6 months and is accompanied by fatigue, which is often profound, … |
SARAH SCHIEBLER; | 2022-07-01 |
| 50 | Vagus Nerve Stimulation As Treatment for Long Covid PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many patients do not recover following Covid infection. The resulting illness is called Long Covid. Because there is no agreed upon treatment for this ailment, the research team has decided to do an open label pilot study using non-invasive, transcutaneous stimulation of the auricular branch of the vagus nerve. Inclusion criteria required the patient to fulfill criteria for having chronic fatigue syndrome. To date, fourteen patients provided evaluable data. Eight of these fulfilled the study’s requirements for treatment success. |
BENJAMIN NATELSON; | 2022-06-06 |
| 51 | Biofeedback and Hydrogen Water As Treatments for Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this 10-week pilot study is to explore the potential benefit of two recently developed non-invasive interventions, heart rate variability biofeedback (HRV-BF) and OTC supplement hydrogen water, for the symptoms of chronic fatigue syndrome (CFS). Symptom measures and heart monitoring information will be generated by this study. Given the lack of effective treatments in this illness, these two non-invasive home-based treatments may help patients feel and function better. |
FRED FRIEDBERG; | 2022-05-23 |
| 52 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID – A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Inpatient, multimodal rehabilitation represents one of the most important interventions in the disease management of post/long COVID. Different professional societies, including the German Society of Pneumology and the European Respiratory Society, recommend rehabilitation intervention to reduce the sequelae of COVID-19. However, from the perspective of science and practice, there are relevant areas that have been insufficiently investigated and are essential for the treatment success of post/long COVID patients: * Differentiation of rehabilitation effects from natural recovery after COVID-19. * Lack of personalized and symptom-based treatment approaches that can address the heterogeneity of symptoms in post/long COVID * Lack of uniform, … |
ANDREAS REMBERT KOCZULLA; | 2022-05-20 |
| 53 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of The Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for The Treatment of Patients With Post-COVID Asthenic Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: to assess executive network using resting-state fMRI and patterns of brain activation using task fMRI with a cognitive paradigm, against the background of taking the drug in comparison with placebo in patients with post-COVID asthenic syndrome. |
MARINE TANASHYAN; | 2022-05-18 |
| 54 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronavirus-2019 (COVID-19) is a viral disease leading to respiratory dysfunction, but it may also affect the brain and result in the development of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This may be the result of the COVID-19 virus infecting regions of the brain responsible for respiratory control. The symptoms of COVID-19 long haulers and ME/CFS may be lessened via an 8-week inspiratory muscle training protocol which is a simple and easy training protocol which can be done at a patient’s home. Thus, … |
HEATHER EDGELL; | 2022-05-09 |
| 55 | The Effects of Inspiratory Muscle Training Immediatley After Lung Transplantation: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Following lung transplantation (LTX), patients may exhibit respiratory and skeletal muscle weakness that will affect exercise capacity, increase dyspnea and fatigue, limit activities of daily living (ADL) and decrease quality of life. Inspiratory muscle training (IMT) has been extensively studied in a variety of non-LTX populations and research has shown that IMT improves exercise capacity, diaphragmatic thickness, … |
CRISTIANE MEIRELLES; | 2022-04-20 |
| 56 | Central Sensitization and Releated Factors in Medical Students: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Central sensitization (SS); is a physiological phenomenon caused by neuronal dysregulation and hyperexcitability in the central nervous system, resulting in hypersensitivity to painful and painless stimuli.Central sensitization syndromes (CSS); defines disorders in which SS originates and cannot be medically explained by any organic cause. CSS include clinical conditions such as fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), temporomandibular joint disorders (TMD), migraine/tension type headache, irritable bowel syndrome (IBS), restless legs syndrome (RLS). These disorders have many common clinical features such as pain, fatigue, sleep disturbance, increased sensitivity to painful and painless stimuli, coexistence, paresthesia, psychosocial disorders, … |
NIHAN ERDINC GUNDUZ; | 2022-04-01 |
| 57 | Effects of Balneotherapy for Patients With Post-COVID Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled study is to evaluate the effects of balneotherapy (BT) and aquatic exercises in patients with post-acute COVID syndrome (PACS). The main question it aims to answer are: • Does BT and aquatic exercises alleviate some of the most prevalent features that characterize post-acute COVID syndrome? Participants allocated to the intervention group will undergo 3 weekly sessions of BT and aquatic exercises on alternate days in groups of 8 during 4 weeks. Prior the beginning of the intervention, … |
XAVIER NOGUÉS SOLAN; | 2022-03-29 |
| 58 | A Randomized Double Blind Placebo Controlled Trial to Determine The Effects of Oxaloacetate on Improving Fatigue in ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is no approved treatment for fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a condition with as many as 2.5 million people in the US. Initial case studies have shown an improvement in fatigue in ME/CFS with anhydrous enol-oxaloacetate (AEO). This randomized, double blinded, placebo controlled trial will seek to further evaluate the efficacy of AEO to reduce fatigue in ME/CFS, based on change in the Chalder Fatigue Score (Likert Scoring) of the AEO group against the placebo group at 90 days. As secondary evaluations on other core ME/CFS symptoms, … |
SUZANNE D VERNON; | 2022-03-15 |
| 59 | Obstructive Sleep Apnea in Patients With Long COVID-19 Fatigue: A Multicentre Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Identify the relationship of obstructive sleep apnea (OSA) prevalence with post-COVID-19 fatigue that remains at least six months after acute disease |
LIGIA PIRES; | 2022-03-10 |
| 60 | Factors Associated With Hospitalization for Dengue and Dengue Severity: Hospital-based Cohort Study on Reunion Island PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years, dengue has become endemic on La Réunion island, which has led to subsequent increase of secondary dengue infections, higher severity and higher mortality of the cases referred to the hospital. This project will investigate the factors associated with the hospitalization for dengue and the factors associated with dengue severity in a hospital-based cohort study conducted over two dengue seasons, as well as the long-term outcomes over aN18-month follow-up. |
CENTRE HOSPITALIER UNIVERSITAIRE DE LA RÉUNION | 2022-03-03 |
| 61 | Amygdala and Insula Retraining (AIR) Program and HUS Internet Therapy Compared to Treatment As Usual in Bodily Stress Syndrome, Fibromyalgia, Post Covid-19, and Chronic Fatigue Syndrome (ME/CFS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will compare an Amygdala and insula retraining (AIR) program to an internet therapy developed at Helsinki University Hospital. The study will be a multi-center randomized controlled trial. Study units will be recruited from the Network for Functional Disorders that is hosted by the HUS Clinic for Functional Disorders and potentially later from international collaborators. The trial will clarify whether internet-based non-drug based therapies are helpful in overcoming the central sensitization and the functional disabilities caused by these disorders. |
HELENA LIIRA; | 2022-01-31 |
| 62 | The Role Of Central Sensitisation In Women With Endometriosis: A Prospective Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Gathering some information obtained during the gynaecological examination and transvaginal ultrasound check-up to be able to assess the prevalence of Central Sensitisation Syndrome (CSS) in women with endometriosis and also to be able to assess related risk factors. CSS has been defined as an algic syndrome due to a hyperactivation of the sensitivity circuit at a central level; the diagnosis is based on the result obtained from a questionnaire, the Central Sensitisation Inventory (CSI), which evaluates the presence and intensity of 25 clinical symptoms. For this reason, … |
DIEGO RAIMONDO; | 2022-01-14 |
| 63 | Effectiveness of Aerobic Exercises and Laughter Yoga Compared With Yoga in Anxiety and Depression Levels of Breast Cancer Survivors; A Double-blind Three Arm Clinical Trial Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 90% of breast cancer survivors experience cancer-related fatigue which decreases the physical activity. Moreover, due to the cancer treatments depression and anxiety will be happened. Previous studies showed the effect of physical activity on reduction of depression and anxiety; therefore the aim of this study is to evaluate the effectiveness of aerobic exercises and laughter yoga compared with yoga in anxiety and depression levels in breast cancer survivors. |
FATEME ABEDINI; | 2022-01-05 |
| 64 | Natural History of Post-Coronavirus Disease 19 Convalescence at The National Institutes of Health PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: People who get COVID-19 have a wide range of symptoms. They also recover from COVID-19 in different ways. In this study, researchers will use survey data to describe the different ways people experience and recover from COVID-19. They will also use the data to help create future studies to understand why some people do not fully recover. Objective: To learn more about the range and timing of symptoms that people have before, during, … |
BRIAN T WALITT; | 2022-01-02 |
| 65 | Water and Land-based Exercise for Children With Post COVID-19 Condition PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The latest data indicate that post COVID-19 condition is frequent in children and adolescents, with the most common symptoms being fatigue, shortness of breath, exercise intolerance and weakness. Evidence that COVID-19 can have significant long-term effects on children’s health highlights the need for measures to reduce the impact of the pandemic on children, ensuring that they receive appropriate treatments. Those experiencing post COVID-19 condition require more tailored exercise-related advice and improved support to be able to resume activities important to their individual well-being. To the best of our knowledge, … |
ANNA OGONOWSKA-SŁODOWNIK; | 2022-01-01 |
| 66 | Chinese Medicine for Residue Symptoms of COVID-19 Recovered Patients- A Double-blind, Randomized, Placebo-controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: COVID-19 has spread rapidly and now affects all over the world. On 11 March 2020, coronavirus disease 2019 (COVID-19) was declared a global pandemic by the World Health Organization (WHO). Most of the infected people will develop mild to moderate illness, for example fever, cough, tiredness and joint pain etc. For some older people, and those with comorbidities like cardiovascular disease, diabetes, chronic respiratory disease, and malignancy are more likely to develop serious illness. Also long-term problems such as fatigue, … |
LIN ZHIXIU; | 2022-01-01 |
| 67 | Design and Validation of An Energy Level Diary for Fatigue Management in Patients With Post-COVID Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-COVID-19 Syndrome (PCS) is characterized by symptoms, including fatigue, reduced physical performance, dyspnea, cognitive impairment, and psychological distress. Pateints have difficulties with energy management and often feel drained even after simple motor or cognitive tasks, which often leads to so called Crashes, after which patients are often bedridden for several day. This study examined wether an energy diary would facilitate the process of pacing during rehabilitation and beyond. |
UNIVERSITY OF WITTEN/HERDECKE | 2022-01-01 |
| 68 | POTS-CFS Study: A Case-Control Study on Exertion and Orthostatic Intolerance in The Context of Pediatric ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pilot-case-control study on exertion and orthostatic intolerance of adolescents with myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) compared to age-matched healthy controls (HC). |
TECHNICAL UNIVERSITY OF MUNICH | 2021-12-06 |
| 69 | Effectiveness and Health Benefits of A Nutritional, Chronobiological and Physical Exercise Primary Care Intervention in Fibromyalgia and Chronic Fatigue Syndrome: SYNCHRONIZE + Mixed Methods Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic pain, fatigue and insomnia are classical symptoms of Fibromyalgia and Chronic Fatigue Syndrome, affecting seriously life quality. Non-pharmacological multicomponent approach is gaining relevance in Fibromyalgia treatment. However, nutrition and chronobiology are often not approached in-depth despite their potential. Furthermore, programs addressed to Chronic Fatigue Syndrome are still scare. This study aims to evaluate the effectiveness of a compact multidisciplinary group intervention based on nutrition, chronobiology and physical exercise in the improvement of lifestyle and life quality in Fibromyalgia and Chronic Fatigue syndrome. |
NOÈLIA CARRASCO-QUEROL; | 2021-10-04 |
| 70 | Long-term Sequelae of COVID-19 (Myalgic Encephalomyelitis): An International Cross-Sectional Study PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The term recovery from COVID-19 caused by SARS-CoV-2 is unverified because the infection leaves many symptoms due to permanent effects on multiple organs; The primary objective of this research is to understand acute and chronic long COVID symptoms by asking questions detecting patient’s experience especially symptoms lasting for several months which is known as chronic fatigue syndrome(Myalgic encephalitis). The study focuses on symptoms describing Myalgic encephalitis which may still affect COVID patients for several months after the infection along with making a big picture about rare symptoms that may the patient experienced during or after the infection. A secondary objective of this research is to focus on the long-term sequelae effects and comorbidities following COVID-19 vaccination. |
ALEXANDRIA UNIVERSITY | 2021-09-01 |
| 71 | A Longitudinal Study on Longstanding Complicated Fatigue: Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS), Burnout Syndrome and Post-covid Fatigue PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to investigate if there are common biopsychosocial vulnerability factors for developing and maintaining fatigue, regardless of the diagnosis. The investigators also believe that subgroups differ in terms of these factors. Participating patients with ME/CFS, burnout syndrome and post-covid fatigue complete a web form at inclusion and after 1, 2, 4, 6, 12, … |
ANNA ANDREASSON; | 2021-08-24 |
| 72 | Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME) By Lipidomics, Metabolomics, Microbiome and Exome Analysis and Investigation of Clinical Improvement Under Administration of Probiotics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue Syndrome (CFS/ME) by Lipidomics, Metabolomics, Intestinal and Peritoneal Microbiome Analysis and Exome Analysis and Investigation of a Possible Benefit of Probiotics. |
MICHAEL JELDEN; | 2021-07-20 |
| 73 | Influence of Co-diagnosis of Chronic Fatigue Syndrome in Patients With Fibromyalgia on Physical Activity, Quality of Life and Immunoneuroendocrine Response PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate differences in neuroimmunoendocrine response and quality of live in patients diagnosed with Fibromyalgia, with or without a co-diagnosis of Chronic Fatigue Syndrome. |
EDUARDO OTERO CALDERÓN; | 2021-06-09 |
| 74 | Exploring The Biological Basis of Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To collect blood and urine samples from patients with Chronic Fatigue Syndrome (CFS), myalgic encephalomyelitis (ME), and SEID (Systemic Exertion Intolerance Syndrome) and controls for genomic, viral and metabolomic testing. |
DXTERITY DIAGNOSTICS | 2021-05-26 |
| 75 | Technology Assisted Solutions for The Recognition of Objective Physiological Indicators of Post-Coronavirus-19 Fatigue PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Preliminary research from our group indicates that up to half of COVID-19 patients are experiencing symptoms consistent with severe fatigue a median of 10 weeks after their initial illness, while almost one third of those previously employed have not returned to work. At present, most clinical and research measurements of fatigue have relied upon self-reported perception of sensations such as exhaustion or weariness. Using such tools, there is an inherent challenge for clinicians in differentiating between patients who are experiencing fatigue at a psychosocial level, … |
ROMÁN ROMERO ORTUÑO; | 2021-05-17 |
| 76 | Neurologic Symptoms After Non-severe COVID-19 : Analysis and Diagnosis Assessment of Somatic Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A growing number of studies highlight the persistence of symptoms after the acute phase of SARS-CoV-2 infection, including in outpatients with mild to moderate forms of the disease. More than 80% of patients with persistent post-COVID-19 symptoms reported neurologic and neurocognitive disturbances. The pathophysiological mechanism is currently unknown, … |
CENTRE HOSPITALIER DE SAINT DENIS | 2021-04-22 |
| 77 | A Double-Blind, Randomized, Placebo-Controlled, Single-Center, Flexible Titration Study Evaluating The Efficacy of Solriamfetol in Treating Fatigue and Cognitive Symptoms in Adults Aged 18-65 Years With A Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an 8-week single center, randomized, double-blind, placebo-controlled, flexible titration trial evaluating the efficacy of solriamfetol in the treatment of fatigue symptoms in adult patients with chronic fatigue syndrome. Subjects will be randomized to a solriamfetol group or placebo group. The investigators will utilize an intent to treat model and impute data. The overall goal of this study is to determine the efficacy and effectiveness of solriamfetol for treating chronic fatigue syndrome. |
JOEL L. YOUNG; | 2021-04-01 |
| 78 | SingStrong: Strong Lungs Through Song PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evidence is emerging that many individuals who recover from Covid-19 are experiencing a range of residual problems. These include fatigue, pain, reduced exercise tolerance and breathing issues. This study includes participants who are experiencing problems with their lungs such as breathing difficulties, shortness of breath, … |
ROISIN CAHALAN; | 2021-03-29 |
| 79 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder and Multiple Chemical Sensitivity Compared to Healthy Controls – The Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Functional somatic disorders (FSD) are frequent in all medical settings and characterized by persistent physical symptoms that cannot be explained by other somatic or psychiatric conditions. In recent decades, a number of different types of functional somatic disorders have been defined, but so far there is no clear explanation for the pathophysiology. The high prevalence of olfactory problems in some patients with FSD suggests that olfactory symptoms are a potential diagnostic biomarker, especially in patients with multiple chemical sensitivity (MCS). The olfactory system is a unique sense with direct pathways to the limbic system, … |
LISE GORMSEN; | 2021-03-23 |
| 80 | The Influence of Epigenetic Modifications and Post-Exertional Malaise in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Exploring epigenetic mechanisms of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is crucial to understand the mechanisms underlying its pathophysiology. Three potential candidates have been selected (BDNF, COMT, and HDAC genes). DNA methylation in the promoter regions of those genes will be explored. The investigators designed a randomised controlled trial and will enrol 70 patients with ME/CFS and 35 age-, sex-, … |
ANDREA POLLI; | 2021-03-15 |
| 81 | Risk Factors for Post-coronavirus Disease-2019 Fatigue: A Prospective Case-control Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: COVID-19 is consistently spreading throughout the world, and the number of recovered patients is steadily increasing. Accordingly, a significant number of individuals will develop persisting post-COVID symptoms, while many of them will report on lasting fatigue. The main objective of the current study is to assess risk factors for the development of post-COVID-19 fatigue symptoms. As a secondary aim, the current study is intended to identify pathophysiology and explanatory mechanisms for the post-COVID-19 fatigue. Study design and population: a nested case-control study will be conducted at Rabin Medical Center (RMC), … |
RABIN MEDICAL CENTER | 2021-03-02 |
| 82 | Neuroinflammation in Chronic Systemic Symptoms (CSS): Proof-of-Concept Study Using PET and EEG/ERP Biomarkers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS). |
POPPY SCHOENBERG; | 2021-02-22 |
| 83 | Central Sensitisation in Post Covid-19 Infection Patients: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate whether there are indicators of central sensitisation in patients post covid-19 infection. |
MARC SCHILTZ; | 2021-01-19 |
| 84 | Central Sensitisation in Post Covid-19 Infection Patients: A Cross-sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate whether there are indicators of central sensitisation in patients post covid-19 infection. |
MARC SCHILTZ; | 2021-01-19 |
| 85 | Study to Investigate The Benefits of Dietary Supplement Quercetin for Early Symptoms of COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Quercetin is a flavonoid dietary supplement that occurs in many edible fruits and vegetables. It has remarkable antioxidant, anti-inflammatory, immunoprotective and antiviral properties. It is widely used to boost the body immune system against infections and keeping healthy life-style. The purpose of the present study is to investigate the potential benefits of quercetin for preventing COVID-19 disease progression and symptoms improvement in the early stage of infection. |
KING EDWARD MEDICAL UNIVERSITY | 2021-01-11 |
| 86 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: A Prospective Randomized Controlled Crossover Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) will receive bright light therapy through portable lamps for 2 weeks. They will either start with this treatment and then go through a wash-out period of two weeks followed by a wait period of two weeks or they will start with the wait period, followed by a wash-out period, followed by the treatment phase. Patients are asked to fill out questionnaires (rating their level of fatigue) and they go through a standardized computer test assessing their attention levels, … |
STEFAN SEIDEL; | 2021-01-01 |
| 87 | Assessing Neuroinflammation in Gulf War Illness With Whole-Brain Magnetic Resonance Spectroscopy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this study is to determine if Gulf War Illness (GWI) likely involves neuroinflammation. The investigators hypothesize that GWI involves neuroinflammation. By assessing the five neuroinflammatory outcomes across the brain, the investigators can determine if there are focal or global signs of one or more neuroinflammatory markers in the brains of individuals with GWI. This neuroimaging technique may allow investigators and others to detect cases of GWI neuroinflammation, which would improve treatment decisions as well as the development of new targeted therapies. It is an ideal diagnostic tool because it has low patient risk, is noninvasive, … |
JARRED YOUNGER; | 2020-12-01 |
| 88 | Treatment of CFS and Fibromyalgia With HRG 80 Red Ginseng PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Will a unique form of ginseng be clinically helpful in those with chronic fatigue syndrome and fibromyalgia? |
JACOB TEITELBAUM; | 2020-10-14 |
| 89 | Mechanistic Assessment of N-Acetylcysteine As An Antioxidant Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Through Dose Response and Treatment Target Engagement PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) is an unexplained multisymptom/multisystem disorder for which there are currently no validated treatments. The present exploratory clinical trial aims to advance our understand of the mechanisms of in situ GSH synthesis control through assessment of the response of brain GSH and plasma markers of oxidative stress to different doses of NAC in comparison to placebo, as a potential treatment for ME/CFS that would provide neuroprotection against oxidative stress by restoring cortical GSH reserves. If successful, … |
DIKOMA C. SHUNGU; | 2020-09-01 |
| 90 | The Influence of Beliefs (Fear of Movement, Pain-related Fear, Self-efficacy, and Pain Acceptance) on The Prognosis of Chronic Musculoskeletal Pain: A Prospective Cohort Study. Study Protocol PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic musculoskeletal pain (CMP) is highly prevalent, disabling, and with high socio-economic costs, with many negative effects on quality of life. CMP affects the ability to perform work, social, recreational and domestic tasks, changing the mood and concentration of this population. Despite the worldwide prevalence and socioeconomic burden of CMP, a clear understanding of its etiology and pathogenesis remains elusive. Aims: (i) to analyze the possible level of association between pain-related fear, fear of movement, self-efficacy, and pain acceptance with pain intensity and disability at the start of the study and prospectively evaluate its predictive function; … |
ALEJANDRO LUQUE-SUAREZ; | 2020-08-01 |
| 91 | The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome is a common problem in society. The treatment of this problem is limited. Acupressure is a treatment method that has become widespread and promising in recent years. For this purpose, the effect of acupressure treatment on chronic fatigue syndrome was investigated. |
ISTANBUL MEDIPOL UNIVERSITY HOSPITAL | 2020-05-09 |
| 92 | Comparison of ME/CFS and Long COVID-19 Patients PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the You + ME Registry and Biobank is to collect clinical and patient-reported data and biological samples (e.g. blood) from people living with Myalgic Encephalomyelitis (also known as chronic fatigue syndrome or ME/CFS), people with long-COVID and control volunteers to improve understanding, diagnosis and treatment of these diseases. |
SOLVE ME/CFS INITIATIVE | 2020-05-01 |
| 93 | Effectiveness of Virtual Multicomponent Treatment for Chronic Fatigue Syndrome: VIRTUAL SFCAMINA STUDY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to analyse the effectiveness of the VIRTUAL SFCAMINA multicomponent treatment program as coadjuvant of treatmentas- usual (TAU) compared to TAU alone. In this Randomized Controlled Trial (RCT), in addition to evaluating the clinical effects of VIRTUAL SFCAMINA treatment in the short- and long term. |
MAYTE SERRAT; | 2020-04-21 |
| 94 | Effect of Probiotic Food Supplement GutMagnific™ in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known As Post-viral Fatigue Syndrome, and Comorbid Gastrointestinal Complications PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a neurological disease. Currently there is no effective treatment for ME/CFS due to unclear etiology of the disease. The aim of this randomized double-blind placebo-control clinical trial is to study the efficacy of the probiotic food supplement GutMagnific™ in ME/CFS and comorbid gastrointestinal complications. The outcome of the study will be assessed based on the data from different self-reporting questionnaires and intestinal microbial flora analysis. |
PER JULIN; | 2020-03-30 |
| 95 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess The Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Quality of Life After The Administration of ImmunoVita® in Chronic Fatigue Syndrome Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS / MS) is a medical entity characterized mainly by debilitating and prolonged fatigue lasting more than 6 months, post-exertion fatigue (physical and / or mental), non-sleep restorative, cognitive impairment and orthostatic intolerance with prolonged recovery that is not relieved by rest. Currently, the etiopathogenic mechanisms of the disease are not known, although mitochondrial dysfunction with bioenergetic immuno-metabolism alterations, oxidative stress, and immuno-inflammatory response stands out. At present, there is no diagnostic test, nor effective treatment in the disease. ImmunoVita, is a food supplement composed of the latest yeast beta-glucans, … |
JOSÉ ALEGRE; | 2020-03-16 |
| 96 | A Pilot Study for Continuous Monitoring of Physical Activity Using Activity Armbands for 6 Months: Assessment of Feasibility and Comparison to Self-reported Questionnaires PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will assess the feasibility of activity monitoring armbands for continuous measurement of physical activity level in ME/CFS patients, during 6 months follow-up. The main purpose is to assess if continuous measurement of activity level may be incorporated in outcome measures in future clinical interventional trials. |
HAUKELAND UNIVERSITY HOSPITAL | 2020-03-11 |
| 97 | A Non-Interventional Pilot Study to Explore The Role of Gut Flora in Eczema PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding eczema. |
SABINE HAZAN; | 2020-03-02 |
| 98 | A Non-Interventional Pilot Study to Explore The Role of Gut Flora in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). |
SABINE HAZAN; | 2020-03-02 |
| 99 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Myalgic encephalomyelitis/Chronic fatigue syndrome (ME/CFS), otherwise known as Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME), is an under-recognized disorder whose cause is not yet understood. Suggested theories behind the pathophysiology of this condition include autoimmune causes, an inciting viral illness, and a dysfunctional autonomic nervous system caused by a small fiber polyneuropathy. Symptoms include fatigue, cognitive impairments, gastrointestinal changes, exertional dyspnea, … |
DAVID SYSTROM; | 2020-01-14 |
| 100 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of The Patients With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Gut microbiota of 1) patients with chronic fatigue syndrome and 2) their healthy family members are analyzed. Up to 40 patients with chronic fatigue syndrome are randomized to receive either 1) a faecal transplant from a healthty donor or 2) their own feces via colonoscopy. Patient’s health related quality and ability to work are assessed (baseline, 1 and 6 months after the procedure) |
TAPANI SALONEN; | 2020-01-01 |
| 101 | CBT Based Group Therapy for Patients With Chronic Fatigue Syndrome (CFS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome is a severe medical condition. It is characterized by long term fatique and other persisted symptoms, such as a cognitive disabilities and orthostatic intolerance. Symptoms limit a persons ability to carry out ordinary daily activities. In ICD- 10, disease is known as G93.3, postviral fatigue syndrome. The purpose of this research (doctoral study) is to produce a psychological, cognitive behavioral therapy (CBT) based group intervention for CFS- … |
JOINT AUTHORITY FOR PÄIJÄT HÄME SOCIAL AND HEALTH CARE | 2019-10-31 |
| 102 | A Randomized, Double-blind, Comparator-controlled, Cross-over Study to Investigate The Safety and Efficacy of RiaGev™ in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This current randomized, double-blind, comparator-controlled, cross over study investigates the efficacy and safety of RiaGev™ via evaluation of NAD+, ATP, glucose, insulin, glutathione, and cortisol levels in healthy adults of ages 36-65. |
TRISHA SHAMP; | 2019-10-25 |
| 103 | Autonomic Neuropathy and Its Pathophysiology in Autoimmune Autonomic Neuropathies, Postural Orthostatic Tachycardia Syndrome and Ehlers Danlos Syndromes: Peripheral Autonomic Small Fiber Neuropathy or Central Autonomic Failure? Validation of The Malmö POTS Score and A Better Diagnosis of POTS in Patientes With Autnomic Failure (VaGeMAPS-3-step-Diag) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care. |
ANDREA MAIER; | 2019-09-15 |
| 104 | Hypermobility and Obstructions in The Craniocervical Region Among Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A retrospective study on clinical and radiological findings in ME/CFS |
BRAGEE CLINICS | 2019-06-01 |
| 105 | Hydrogen Water As A Treatment for Chronic Fatigue Syndrome: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed placebo-controlled pilot study will examine hydrogen water as a treatment for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). 25 subjects who meet strict criteria for ME/CFS will be recruited. The 30 day trial will involve subjects ingesting 1-5 8 oz. glasses of hydrogen-dissolved water per day. The placebo condition will involve the same daily ingestion schedule but with an inert placebo pill instead of the active hydrogen treatment pill. The proposed study is intended to establish feasibility of the clinical protocol and examine potential treatment effects of hydrogen water which may include symptom reduction and possibly improved functioning. If feasibility and apparent treatment effects are confirmed, a large clinical trial will be proposed for submission to NIH. In addition to potential therapeutic properties, H2 water is portable, easily administered and safe to ingest. Self-report assessments for ME/CFS symptoms, fatigue, autonomic symptoms, physical function, anxiety, and depression will be done in the week before and the week after the 30 day trial. In addition, 7-day home-based objective assessments of heart rate variability (a measure of parasympathetic function) and accelerometry (a physical activity assessment) will be scheduled before and after the intervention period. |
FRED FRIEDBERG; | 2019-04-01 |
| 106 | Molecular Response to Custom Manual Physiotherapy Treatment of Fibromyalgia & Chronic Fatigue Syndrome (CFS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fibromyalgia (FM)and Chronic Fatigue Syndrome (CFS) are complex diseases often presenting overlapping symptomatology. Manual therapy (MT) protocols report benefits for pain treatment of FM, but the underlying mechanisms for patient improvement remain unknown. The main goal of this study is to assess the molecular changes associating to mechanical and additional MT triggers, possibly involved in patient symptom improvement. |
MARÍA GARCÍA ESCUDERO; | 2019-03-20 |
| 107 | Assessment of Exercise Response in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the correlation between the 6-min walking test (6MWT) with gases measurement, and the peak cardiopulmonary exercise testing (CPET) using incremental cycling with gases and workload measurement, in order to determine if the 6MWT detects impairment in exercise tolerance and if it avoids the post-exertional malaise that the peak CPET causes on decreasing levels of physical activity, in participants affected by chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME). Physical activity level at baseline (usual activity, the parcipant will not be given any directions) will be recorded during 7 days, 24 hours/day. Afterwards, … |
SUSANA GARCÍA JUEZ; | 2019-02-27 |
| 108 | Randomized Controlled Trial Comparing Two Different Bladder Instillation Treatments for Interstitial Cystitis/Bladder Pain Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a condition that results in long-term bladder and pelvic pain. IC/BPS affects women more often than men. How the disorder develops is not completely known. Bladder instillation is a commonly used treatment in which a mixture of different ingredients are passed into the bladder to help IC/BPS symptoms. There is room to learn more about bladder instillations and which ingredients in them work best. The purpose of this study is to compare the effectiveness of a bladder instillation that contains a steroid (triamcinolone acetonide) to a bladder instillation that does not contain a steroid to treat IC/BPS in women. The study hypothesis is that women with IC/BPS treated with bladder instillations that contain a steroid will have improved outcomes compared to women treated with bladder instillations that do not contain a steroid. |
OLIVIA CARDENAS-TROWERS; | 2019-01-25 |
| 109 | Evaluation of The Neuromedulatory Effect of Transcranial Direct Current Electrical Stimulation (tDCS) in Carpal Tunnel Syndrome (CTS): A Double Blinded Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double blinded randomized clinical trial to study the neuromodulatory effect of tDCS in patients with CTS, the study subject will be randomly into two groups; active and sham group , the active group will receive five sessions of active TDCS over the M1 while the Sham group will receive sham tDCS in which the device will be turned off after 30 seconds. The patient will be assessed by VAS score, Boston carpal tunnel questionnaire , central sensetization inventory , pressure pain threshold, sensory and pain threshold for electerical stimulation before , … |
GEHAD SWILAM ABDELMONEM SWILAM; | 2018-12-16 |
| 110 | Shanghai University of Traditional Chinese Medicine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to disclose the mechanism of characteristic Tao yin exercises regulate Chronic Fatigue Syndromes based on Brain-Gut Axis.Explore the clinical manifestation of Chronic Fatigue Syndromes, changes of neurotransmitter and central brain function. Then provide some new methods of treating Chronic Fatigue Syndromes. |
SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE | 2018-12-01 |
| 111 | Study of The Pathogenic Mechanisms of Metabolic Syndrome at The Background of Genetically Determined Insulin Resistance in Childhood Cancer Survivors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The research is devoted to studying the features of the metabolic syndrome in cancer survivors in childhood is supposed to answer the following questions: – How can metabolic syndrome be diagnosed in the Russian population of survivors of acute lymphoblastic leukemia and non-Hodgkin’s lymphomas? – What are the features of the clinical symptoms of metabolic syndrome in this category of patients? – Which genetic mutations are found in cancer survivors of patients with metabolic syndrome; … |
FEDERAL RESEARCH INSTITUTE OF PEDIATRIC HEMATOLOGY ONCOLOGY AND IMMUNOLOGY | 2018-11-20 |
| 112 | A Randomized-controlled Clinical Trial of Hypnosis Versus Open Label Placebo for Chronic Neuropathic Pain With An Investigation of Neuro-cognitive Dysfunctions As Maintaining Factors and Therapeutic Targets PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to a) assess the presence of a maladaptive stress response, a decreased pain modulation and any cognitive impairment in patients with chronic neuropathic pain in comparison to healthy controls. and b) evaluate the efficacy of a treatment of hypnosis and of an open label placebo on these neuro-cognitive factors and on clinical pain. This will be done through a) a prospective observational comparative study of patients (base line measures) with Healthy Controls (HC) and b) an Open label; randomised, hypnosis vs. open label placebo (OLP) vs. treatment as usual control design; … |
CHANTAL BERNA; | 2018-11-01 |
| 113 | Probing Metabolism, Circulating Inflammatory Molecules, Extracellular Vesicles and Immune Dysregulation in Individual Immune Cells in ME/CFS PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to collect and identify key outcome measures or disease parameters in ME/CFS that are altered during elevated symptoms relative to baseline by gathering information before and after symptom provocation using a two-day cardiopulmonary exercise test. |
ITHACA COLLEGE | 2018-08-01 |
| 114 | Pilot Phase 1/2, Open-Label, Clinical Trial to Investigate CT38 in The Treatment of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to investigate the safety, tolerability and efficacy of CT38, an experimental peptide administered by subcutaneous infusion, in the treatment of ME/CFS patients. |
LUCINDA BATEMAN; | 2018-07-23 |
| 115 | Developing An Activity Pacing Framework for The Management of Chronic Pain/Fatigue. Stage III: Feasibility and Acceptability Studies PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study explores whether it is feasible to use a newly developed activity pacing framework to standardise how activity pacing is instructed by healthcare professionals in rehabilitation programmes for patients with chronic pain/fatigue. |
DEBORAH ANTCLIFF; | 2018-05-21 |
| 116 | New MRT Imaging Biomarkers and Treatment With Kinetic Oscillatory Stimulation (KOS) in Nasal Cavity for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Placebo controlled trial study of efficacy of Kinetic Oscillation Stimulation (KOS) in nasal cavity will be conducted in patients with myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The outcome of the treatment will be assessed with clinical evaluation of patients, cognitive tests, structural and functional MRI of the brain. |
TIE-QIANG LI; | 2018-04-17 |
| 117 | Defining Autoimmune Aspects of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates whether there is an immune response directed against gut microbes or food and parts of the body in severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients. |
SIMON CARDING; | 2018-03-28 |
| 118 | Central Sensitization in Vitamin D Deficiency and Effect of Vitamin D Replacement on Cutaneous Silent Period PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the presence of central sensitization in vitamin D deficiency and its effect on cutaneous silent period, pain, and quality of life. The secondary purpose of the study is to investigate whether a change in cutaneous silent period parameters, pain severity and neuropathic sensitization and quality of life after vitamin D replacement. |
OZGE KENIS COSKUN; | 2018-01-28 |
| 119 | Role of The NLRP3 Inflammasome Activation, Mitochondrial Biogenesis, and Immunoinflammatory Response After Oral Coenzyme Q10 Plus Selenium Supplementation in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years, it has been suggested that nutritional deficiencies may be of causal relevance in individuals with ME/CFS. These include deficiencies of vitamins and trace elements. It is likely that the observed nutritional deficiencies contribute to the core symptoms of the disease. Coenzyme Q10 (CoQ10) has been studied as an alternative and complementary therapy in ME/CFS for fatigue, pain, tiredness, neurocognitive impairment, and sleep problems. This demonstrates how alterations in energy metabolism, mitochondrial dysfunction, oxidative stress, imbalance of the immune-inflammatory response, and activation of the NLRP3 inflammasome are likely consequences of low levels of CoQ10 and selenium, … |
JOSÉ ALEGRE; | 2018-01-01 |
| 120 | Sex Differences in Exercise-related Post-exertional Malaise in ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot study is intended to identify sex differences in myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) during recovery from brief but high effort exercise tests. It is expected that women with ME/CFS as compared to males with ME/CFS will show slower recovery from exercise with respect to heart rate and blood pressure, physical functioning, and symptom severity. Also females with ME/CFS as compared to males with ME/CFS will show greater negative impacts on heart rate, blood pressure, … |
FRED FRIEDBERG; | 2017-11-01 |
| 121 | Effect of Coenzyme Q10 Plus NADH Supplementation on The Changes in Fatigue Perception, Sleep Disturbances, Autonomic Function and Health-related Quality of Life in CFS/ME – A Randomized, Placebo-controlled, Double-blind Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the study is to examine the effect of oral CoQ10 plus NADH (Reconnect®) supplementation twice daily for 8-weeks on the changes in fatigue perception, sleep disturbances, autonomic dysfunction and HRQoL assessed by patient-reported outcome measures in CFS/ME. |
JOSE ALEGRE; | 2017-06-28 |
| 122 | Development and Clinimetric Properties of The Dutch Pediatric Neurophysiology of Pain Questionnaire in Healthy Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The scientific objective of this research implies developing and examining the clinimetric properties of the Dutch Pediatric Neurophysiology of Pain Questionnaire (PedNPQ) in healthy children. A total study sample of 60 healthy children (30 from 2nd and 3rd primary school) will be included to measure test-retest reliability of the Pediatric Neurophysiology of Pain Questionnaire (PedNPQ). Children will be asked to fill in the questionnaire twice, with a time interval of 48 hours (assessment T0 and T1). In order to assess concurrent validity of the PedNPQ, … |
ROSELIEN PAS; | 2017-06-12 |
| 123 | Multicenter Study, Randomized, Parallel Group Controlled, Testing The Effectiveness of A Behavioral Cognitive Therapy (BCT) Vs Usual Local Practice on The Fatigue of Patients With Relapsing Remittent Multiple Sclerosis (RRMS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multiple sclerosis (MS) is a chronic inflammatory disease that leads to demyelination of the central nervous system. Fatigue is one of the most frequent and most disabling symptoms of MS. Up to 86% of individuals with MS experience fatigue at any one time; 65% consider it to be one of their three most troubling symptoms. Fatigue may limit or prevent participation in dayly activities and reduce psychological well-being (1, 2). Pharmacological and non-pharmacological treatments are available for MS-related fatigue, but evidence on effectiveness is mostly inconclusive or non-existent. The psychological approaches of fatigue management are interesting. To date, … |
OLIVIER HEINZLEF; | 2017-05-31 |
| 124 | Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic pain and fatigue are characterized by peripheral and central mechanisms including low pain thresholds, temporal summation, peripheral and central sensitization. This application will focus on central factors of chronic pain and fatigue. Functional brain imaging will be used to characterized brain and spinal cord abnormalities that contribute to the mechanisms of these disorders. |
ROLAND STAUD; | 2017-03-15 |
| 125 | The Possible Beneficial Effects of Mindfulness-Based Cognitive Therapy (MBCT) in Fatigued Adult Patients With Inflammatory Bowel Disease (IBD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current study aims to investigate the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) for reducing fatigue in Inflammatory Bowel Disease patients in remission. |
MAYA SCHROEVERS; | 2017-01-18 |
| 126 | Noradrenergic and Stress-Related Etiologies of Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to measure sympathetic nervous system function and stress responses in patients with clinically documented and self-reported chronic fatigue that is worsened by stress, compared to healthy controls. Baseline norepinephrine (NE) levels and stress-induced NE levels in patients who fulfill criteria for Chronic Fatigue Syndrome (CFS) and who self-identify with stress induced worsening fatigue, will be compared to data from normal individuals pre and post-stress. |
GORDON BERNARD; | 2017-01-01 |
| 127 | High-tech Acupuncture for Treatment of Chronic Fatigue Syndrome – A Sino-Austrian Cooperation Randomized Controlled Trial(RCT) on Heart Rate Variability PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To study the relationship between Chronic Fatigue Syndrome (CFS) and heart rate (HR) and its variability (HRV). 2. To compare the curative effects and the HR/HRV indices between applicationa of different acupoints as well as different treatments (acupuncture and moxibustion). |
HUBEI PROVINCIAL COLLABORATIVE INNOVATION CENTER OF PREVENTIVE TREATMENT BY ACUPUNCTURE AND MOXIBUST | 2016-11-01 |
| 128 | Thunder-Fire Moxibustion Therapy for Chronic Fatigue Syndrome on Shenque Acupoint: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome is a group of syndrome and is prevalent in adult. Thunder-fire moxibustion is a commentary therapy belonged to acupuncture therapy. To evaluate the effect and safety of thunder-fire moxibustion therapy for chronic fatigue syndrome, we apply a randomized controlled trial by recruiting chronic fatigue syndrome patient as subject, applying thunder-fire moxibustion on shenque acupoint contrasted to common moxa-stick moxibustion, taking fatigue rating scale score, the content of CD3+、CD4+、CD8+、CD4+/CD8+ as evaluation indexes. The treatment time is 20-30 minutes per session, 3-4 times a week, there are totally 15 sessions. |
HAILI LUO; | 2016-11-01 |
| 129 | Fatigue in Sarcoidosis – A Feasibility Study Investigating The Treatment of Fatigue in Stable Sarcoidosis Patients Using Methylphenidate PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a small randomised-controlled trial (RCT) using methylphenidate as a treatment for clinically-significant fatigue in sarcoidosis patients with stable disease. The primary outcomes are feasibility, aimed at determining factors that will influence the design a future, larger RCT, which will be powered to look at clinical efficacy of the intervention. |
ANDREW M WILSON; | 2016-11-01 |
| 130 | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Post-Infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (PI-ME/CFS) refers to long-lasting and disabling fatigue or malaise, inability to recover after exercise, and physical and emotional discomfort that may occur after a person has an infection. Researchers want to learn more about its causes. Objective: To learn more about PI-ME/CFS. Eligibility: Adults ages 18-60 years who have finished at least 7th grade education and either: have ME/CFS that started after an infection OR had Lyme disease, were treated, … |
AVINDRA NATH; | 2016-10-10 |
| 131 | ME/CFS: Activity Patterns and Autonomic Dysfunction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to identify daily activity patterns, negative life events and autonomic abnormalities that may be related to non-improvement in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). For both naturalistic studies and behavioral intervention trials, roughly 50% of patients report worsening or unchanged illness. The proposed four year study would be the first to look at the relation between illness non-improvement, patient activities at home and autonomic function. Our long-range goal is to identify physiological signals and activity patterns that predict non-improvement and relapse and develop a self-management program that prescribes improvement-linked behaviors and discourages non-improvement activities. |
FRED FRIEDBERG; | 2016-06-01 |
| 132 | A Clinical Study About Improvement of Chronic Fatigue After Taking Red Ginseng PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to verify the efficacy of taking red ginseng for chronic fatigue patient. |
EUN JUNG KIM; | 2016-06-01 |
| 133 | MicroRNAs As Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome (CFS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: MicroRNAs were shown to play an important role in regulating pain-processing in a wide range of experimental models and clinical pain disorders. Thus, the aim of the present study is to evaluate a set of Micro-RNAs as diagnostic biomarkers of pain intensity in adolescents with chronic fatigue syndrome (CFS) and to correlate with inflammatory markers and pain related comorbidities. |
SAMI GABR; | 2016-04-01 |
| 134 | An Unicentric, Double-blind, Placebo Controlled, Phase IV Clinical Trial of Oral Melatonin Plus Zinc to Evaluate Relieving Self-reported Fatigue in CFS/ME PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the effects of oral melatonin plus zinc supplementation in relieving self-reported fatigue in CFS/ME |
JOSÉ ALEGRE; | 2016-02-01 |
| 135 | Reducing Orthostatic Intolerance With Oral Rehydration in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can’t tolerate prolonged standing. OI in ME/CFS is often accompanied by either postural tachycardia syndrome (POTS) in which standing results in an excessive heart rate, and neurally mediated hypotension (NMH) in which standing causes a fall in blood pressure and fainting. Intravenous fluids can alleviate these symptoms, but is difficult to administer; oral fluids fail to provide the same benefit. We would therefore like to test the effectiveness of an oral rehydration solution (ORS, … |
MARVIN S. MEDOW; | 2016-02-01 |
| 136 | The Effects of Medium-term Creatine Supplementation in Adults With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the effectiveness of medium-term supplementation with creatine to improve clinical outcomes in well-defined adult CFS population. Half of the participants will receive creatine while the other half will receive placebo. |
SERGEJ M. OSTOJIC; | 2016-01-01 |
| 137 | The Immune Effects of Low-dose Naltrexone in People With Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to test if naltrexone, when taken in low doses, has an anti-inflammatory effect that may be associated with positive clinical outcomes in people with chronic fatigue syndrome (CFS). In part, the present study, is a continuation of prior work in which we showed that chronic fatigue symptoms are associated with immune activity, and that low-dose naltrexone might exert anti-inflammatory effects in fibromyalgia, which is thought to share some pathophysiological and clinical characteristics with CFS. |
JARRED YOUNGER; | 2016-01-01 |
| 138 | Restauration of EBV Control in SLE Phase 1-2 Trial Evaluating Adoptive Transfer of Autologous EBV- Specific Cytotoxic T Lymphocytes in SLE Treatment Related Papers Related Patents Related Grants Related Experts View Highlight: EBV has been implicated in pathogeny of SLE with increase in EBV sero-prevalence, defective control in EBV infection and altered both B and T immune responses to this virus The main objective of this pilot proof-of-concept (POC) study is to evaluate safety and efficacy of autologous EBV specific CTL adoptive transfer in adult patients with serologically active SLE |
NANTES UNIVERSITY HOSPITAL | 2016-01-01 |
| 139 | Mental Training for Chronic Fatigue Syndrome (CFS/ME) Following EBV Infection in Adolescents: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The general aim of this study is to investigate the effect of an individually tailored mental training program in adolescents developing chronic fatigue syndrome (CFS) after an acute Epstein Barr-virus (EBV) infection. Endpoints include physical activity (primary endpoint), symptoms (fatigue, pain, insomnia), cognitive function (executive functions) and markers of disease mechanisms (autonomic, endocrine, and immune responses). |
VEGARD WYLLER; | 2015-10-01 |
| 140 | The PRINCE Secondary Study: Persistent Physical Symptoms Reduction Intervention: A System Change and Evaluation in Secondary Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Brief Summary: Persistent Physical Symptoms (PPS), also known as medically unexplained symptoms (MUS) is a term used to describe a range of persistent bodily symptoms for which the exact cause is unclear. Between 20 and 40% of patients in primary care, and about 50% in secondary care experience PPS. Not only are PPS common, but the overlap across different patient groups may indicate that these phenomena are transdiagnostic. PPS are associated with profound disability and high health care costs, … |
TRUDIE CHALDER; | 2015-07-01 |
| 141 | Persistent Physical Symptoms Reduction Intervention: A Systems Change and Evaluation (PRINCE) – Integrated GP Care for Persistent Physical Symptoms: A Feasibility & Cluster Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PRINCE primary is cluster randomised waiting list controlled trial to evaluate the feasibility of an integrated approach to care in general practice for adults with persistent physical symptoms (PPS). PPS is defined as physical symptoms with no obvious underlying organic. 240 patients with PPS recruited from 8-12 GP practices in London will be randomised to the integrated care approach plus treatment as usual (TAU) or TAU alone. The integrated GP approach consists of providing GPs with a short cognitive behaviour therapy (CBT) skills training, ongoing supervision, as well as written and audio-visual materials/guidelines. In addition, … |
TRUDIE CHADER; | 2015-05-01 |
| 142 | A 60-Day Clinical Study to Evaluate Nutrilite Ginko Biloba Cistanche Tablets in Relieving The Symptoms of Chronic Fatigue Syndromes Compared to Negative Control PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy of Nutrilite® ginkgo biloba cistanche tablets in relieving the symptoms of chronic fatigue syndrome(CFS), the investigators randomly recruit189 subjects with CFS, aged 35-60 yrs. The relief of fatigue and improvement of sexual function are evaluated by World Health Organization Quality Of Life Brief (WHOQoL-Bref), Sexual Life Quality Questionnaire (SLQQ), chronic fatigue syndrome, symptoms of self-assessment at the baseline and the end of intervention. Subjects also underwent a blood test measuring the concentration of biochemical indicators. Cistanche is mainly used to strengthen the renal function, nourish essence and blood in the treatment of lumbar debility, impotence, … |
SHUGUANG LI; | 2015-05-01 |
| 143 | Meriva for Treatment-induced Inflammation and Fatigue in Women With Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of the investigation is to determine if curcumin reduces NF-kB DNA binding and ultimately its downstream mediator IL-6 in patients receiving XRT for their breast cancer after having completed chemotherapy. Patients who have received prior chemotherapy will be eligible, because we have found that this enriched population is at particular risk for exhibiting increased NF-kB DNA binding and IL-6 following XRT. |
ANDREW H MILLER; | 2015-05-01 |
| 144 | Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS). Part A: An Open Label Phase-II Study With Six Intravenous Cyclophosphamide Infusions Four Weeks Apart, and Follow-up for 12 Months PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Significant clinical improvements of ME/CFS symptoms were observed in two patients with long-standing ME/CFS who received adjuvant chemotherapy including cyclophosphamide for breast cancer, also in one ME/CFS patient who received chemotherapy including iphosphamide for Hodgkin lymphoma. Three pilot ME/CFS patients were thereafter treated with six intravenous infusions four weeks apart, in two of these with a significant clinical response. The hypothesis is that a subset of ME/CFS patients have an activated immune system, and that ME/CFS symptoms may be alleviated by treatment with cyclophosphamide as intravenous pulse infusions four weeks apart, … |
MELLA OLAV; | 2015-03-01 |
| 145 | Acceptance and Commitment Group Therapy for Adolescents With A Range of Functional Somatic Syndromes: Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: An increasing number of adolescents report recurrent functional somatic symptoms. Some experience persistent symptoms and may receive functional somatic syndromes (FSS) diagnoses (i.e. symptoms not attributable to any known conventionally defined physical disease), characterised by severe disability and reduced quality of life. The aim of this study is to: 1. Develop an Acceptance and Commitment Therapy (ACT)-based group intervention for adolescents with severe FSS (conceptualized as Bodily Distress Syndrome (BDS), see detailed description). 2. Examine the efficacy of group based ACT in adolescents (aged 15-19 years) with severe FSS. The ACT-based treatment, … |
CHARLOTTE U RASK; | 2015-01-30 |
| 146 | Phase IIa Open Label Study to Evaluate The Safety, Tolerability, and Efficacy of KPAX 002 (Methylphenidate Hydrochloride + K-PAX Synergy) As A Treatment for Gulf War Illness in Patients Meeting The Kansas Case Definition PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Gulf War Synergy Trial will evaluate the safety and efficacy of a currently available medication, methylphenidate (Ritalin®), combined with a GWI Nutrient Formula (K-PAX Synergy) to treat Gulf War Illness (GWI). |
MARK HOLODNIY; | 2015-01-01 |
| 147 | Mindfulness-Based Therapy for Interstitial Cystitis/Bladder Pain Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood disease with unreliable treatments. Although it is not known what causes it for certain, we do know that life stressors may make the disease worse or cause flares. Mindfulness Based Stress Reduction (MBSR) is an 8 week class focused on meditation and other techniques that the investigators think may be helpful to people with IC/BPS. This trial will assign participants to an MBSR class or usual care for their IC/BPS to see if the MBSR class would be helpful for their disease. |
GREGORY KANTER; | 2014-11-01 |
| 148 | Testing The Effects of Methylphenidate on Cognitive Fatigue in Multiple Sclerosis: A Double-blind, Placebo-controlled, Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Up to 95% of individuals with Multiple Sclerosis report experiencing cognitive fatigue, characterized by a lack of energy, feelings of exhaustion, an the perception that one is unable to partake in daily activities. The goal of this project is to test whether methylphenidate (MP), a well-known psychostimulant, … |
KESSLER FOUNDATION | 2014-10-01 |
| 149 | Biopsychological Intervention in Chronic Fatigue Syndrome – A Pilot Study Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study of a biopsychological intervention program for adolescent chronic fatigue syndrome. The program is related to cognitive behavioral therapy, which has been proven beneficial in this disorders, but includes other mental techniques, such as emotional control and metacognitive elaboration. The aim of this pilot study is to explore a) patients’ experiences and b) possible positive effects on symptoms. We hypothesise that the intervention will be regarded feasible by the patients, and that fatigue score will improve during the intervention period. |
OSLO UNIVERSITY HOSPITAL | 2014-10-01 |
| 150 | B-lymphocyte Depletion Using The Monoclonal Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME). A Multicentre, Randomized, Double-blind and Placebo Controlled Phase-III Study With Rituximab Induction and Maintenance Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The hypothesis is that a subgroup of patients with Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME) have a chronically activated immune system and may benefit from B-lymphocyte treatment using the monoclonal anti-CD20 antibody rituximab with induction and maintenance treatment. |
OLAV MELLA; | 2014-09-01 |
| 151 | Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome (CFS) is a debilitating condition of unknown etiology. Recent studies have shown that CFS is associated with impaired cellular energetics and low levels of phosphocreatine. Since guanidinoacetic acid (GAA) acts as a highly bioavailable precursor of creatine it may provide an ideal dietary supplement to facilitate treatment and perhaps prevention of CFS. The overall hypothesis to be evaluated is that medium-term supplementation with GAA will improve clinical outcomes in well-defined adult CFS patients via augmented provision of creatine. Specific aims: (1) To determine the effects of GAA on CFS symptomatology using a fatigue severity inventory, … |
SERGEJ M. OSTOJIC; | 2014-08-01 |
| 152 | A Feasibility Study of A Brief Psychological Intervention for Post-stroke Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a leading cause of adult disability in the community. Fatigue affects about a third of stroke survivors. It results in difficulty taking part in everyday activities, and increases risk of hospitalization and death after stroke. Despite of its high prevalence and distressing consequences, there is no effective treatment. Psychological interventions have improved fatigue in patients with other conditions such as multiple sclerosis. These interventions primarily target patients’ beliefs about overcoming fatigue and their physical activities in daily life. Also studies indicated that post-stroke fatigue is associated with mood. Based on this knowledge, … |
SIMIAO WU; | 2014-07-01 |
| 153 | Cytokine Inhibition in Chronic Fatigue Syndrome Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Chronic fatigue syndrome (CFS) is a medically unexplained syndrome for which no somatic or pharmacological treatment has been proven effective. Dysfunction of the cytokine network has been suspected to play a role in the pathophysiology of CFS. Although derangements of the cytokine network in CFS are controversial, a major problem is that many studies did not use adequate controls. In addition, all studies have been performed on peripheral venous blood of the patients. As cytokines mainly act in the tissues, e.g., the brain, … |
JOS VAN DER MEER; | 2014-06-01 |
| 154 | Cardiopulmonary Exercise Testing As A Diagnostic Tool and A Quantitative Measure of Post-exertional Malaise in Myalgic Encephalopathy/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Circumstantial evidence suggests that patients diagnosed with myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) perform worse on day 2 in a 2-day consecutive cardiopulmonary exercise test (CPET). The aim of this study is to examine if CPET can distinguish between ME/CFS patients and healthy controls. |
PER OLE IVERSEN; | 2014-06-01 |
| 155 | Psychological Wellbeing in Adults With Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: Chronic Fatigue Syndrome (CFS) is a medically unexplained condition characterized by severe and disabling fatigue. To date much research has focused on finding out whether CFS is caused by mainly physical or psychological factors. Perhaps as a result of this, few studies have examined the relationship between CFS and quality of life, in particular, more positive aspects of mental health, such as an individual’s sense of purpose, autonomy and close relationships. This study will address these limitations by examining Ryff’s (1989) six domains of psychological well-being (PWB), and other aspects of well-being including positive emotions, … |
HANNAH JACKSON; | 2014-05-01 |
| 156 | The Efficacy of A Mindfulness Based Intervention for Depressive Symptoms in Patients With Multiple Sclerosis and Their Caregivers. A Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Multiple Sclerosis has a great impact on psychological functioning of patients and can be associated with various psychological disorders and symptoms. The most prevalent one is depression, which ranges from 15% to 47%. Mindfulness Based Intervention (MBI) is a relatively brief and cost-effective program that has been studied in patients with several diseases. Aims. To evaluate the efficacy of a group-based MBI on depressive symptoms, … |
LUCA OSTACOLI; | 2014-05-01 |
| 157 | Slow-wave Sleep and Daytime Functioning in Chronic Fatigue Syndrome: Effects of Sodium Oxybate PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators wish to investigate whether enhancement of SWS, which is seen after a drug called sodium oxybate, reduces the impact of sleep disruption in CFS on daytime function, specifically sleepiness and mental performance. This is a safe and well-tolerated drug that is licensed for excessive daytime sleepiness (EDS) and cataplexy associated with narcolepsy. The investigators will study 12 patients diagnosed with CFS using international diagnostic guidelines. The investigators will record overnight sleep with EEG (brainwave) measurement on the 1st and 4th nights of a 4 night period during which sodium oxybate and placebo will be taken nightly, … |
DAVID NUTT; | 2014-04-01 |
| 158 | Effect of Neuroscience Education on Subjects With Chronic Knee Pain Related to Osteoarthritis : A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great disability and significant healthcare costs. Substantial scientific evidence indicates a role for central sensitization in OA pain. Reconceptualization of pain through Neuroscience Education (NE) is an intervention that has already been used successfully in some chronic musculoskeletal pain conditions characterized by alteration on CNS pain processing or central sensitization (i.e. chronic low back pain, chronic fatigue syndrome, widespread pain and chronic whiplash associate disorders).There is compelling evidence that NE have a positive effect on pain, disability, catastrophization and physical performance for chronic musculoskeletal pain disorders, … |
ENRIQUE LLUCH GIRBÉS; | 2013-12-01 |
| 159 | Randomized, Double-Blind, Placebo Controlled Study to Evaluate The Safety, Tolerability, and Efficacy of Methylphenidate Hydrochloride As A Treatment for Chronic Fatigue Syndrome in Patients Taking A CFS-Specific Nutrient Formula PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Synergy Trial will evaluate the safety and efficacy of a currently available medication (methylphenidate hydrochloride) combined with a CFS-specific dietary supplement (CFS Nutrient Formula) to treat Chronic Fatigue Syndrome (CFS). |
JOSE MONTOYA; | 2013-11-01 |
| 160 | Exertional Exhaustion in Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-exertional malaise was modeled by having Chronic Fatigue Syndrome (CFS) and sedentary control subjects perform submaximal exercise on 2 consecutive days with objective changes in brain function measured by magnetic resonance imaging (MRI) during cognitive tests before and after the 2 exercise sessions. |
JAMES BARANIUK; | 2013-08-01 |
| 161 | Use of A Monitor in ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The use of an activity monitor to determine increase or decrease of activity in patients suffering from chronic fatigue syndrome. |
DEREK ENLANDER; | 2013-07-01 |
| 162 | Observational Research on Use of Immunoprop Supplement in Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Observational study regarding the use of supplements in chronic fatigue syndrome patients |
DEREK ENLANDER; | 2013-06-01 |
| 163 | The Effect of Sodium Oxybate in Patients With Chronic Fatigue Syndrome Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome (CFS) is a disabling, unexplained disorder characterized by physical and mental exhaustion. Complaints of disturbed and unrefreshing sleep are very common in CFS patients, however, the relationship between (disturbed) sleep quality and fatigue is still not fully elucidated. To evaluate the effect of sodium oxybate on fatigue and to explore the interdependence of sleep quality and fatigue in CFS, a double blind, randomized, … |
AN MARIMAN; | 2013-06-01 |
| 164 | Clinical Trial, Randomized, Controlled, Parallel, to Evaluate The Effectiveness of Acupuncture As A Treatment in Patients Diagnosed With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: background: The Chronic Fatigue Syndrome (CFS) presents many disturbances multidimensional affect holistically to people who have the disease and current management of fatigue, pain, anxiety, depression and sleep disturbances present in this clinical entity is unsatisfactory. Hypothesis: The hypothesis of this essay is to contrast that acupuncture is more useful than placebo. The investigators suggest the use of a clinical study protocol (PEC), randomized, placebo-controlled, acupuncture technique, aimed at increasing the patient’s sense of well-being, relief of pain and stiffness, acupuncture is effective to reduce fatigue, anxiety, depression and sleep disorders in patients diagnosed with CFS. |
CONCHITA JIMENEZ GUTIERREZ; | 2013-02-01 |
| 165 | Phase 1 + 2a Proof of Concept Study of Treatment of Chronic Fatigue Syndrome (CFS) With Iodinated Activated Charcoal (IodoCarb®) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome (CFS) is a devastating and complex disorder. People with CFS experience overwhelming fatigue and a host of other symptoms that are not improved by bed rest. Interestingly, many of the symptoms experienced by people with CFS are identical to symptoms caused by long-term low-level exposure to mercury, which is called micromercurialism. This study will examine if the mercury binding substance IodoCarb(r) can improve the health of patients with CFS. |
ANDERS LUTS; | 2013-02-01 |
| 166 | A Randomized, Double-blind, Placebo-controlled, Comparative Clinical Trial to Measure The Maximun Heart Rate During A Cycle Ergometer Test After ReConnect® Supplementation in CFS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective is evaluate to safety and efficacy of oral Reconnect ® (food supplementation composed by Coenzyme Q10, NADH, phosphoserine y vitamin C) on the maximum HR during an exercise test in CFS |
JOSE ALEGRE-MARTIN; | 2013-01-01 |
| 167 | Randomized, Double-blinded, Placebo-controlled, Multicenter Investigator Initiated Clinical Study to Explore The Efficacy and Safety of GCJBP Laennec Inj.(Human Placenta Hydrolysate) 4ml Per Day 3 Times Per Week for 6 Weeks in The Chronic Fatigue Patients With Chronic Fatigue Syndrome or Idiopathic Chronic Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: GCJBP Laennec Injection contains a variety of cytokines derived from human placenta, amino acids, peptides, nucleobases, and carbohydrates. This product is approved for improving liver function. Also, it has been prescribed for lots of diseases such as menopausal disorders, atopic dermatitis, skin cares as well as fatigue for long time. Although its action mechanism and clinical effectiveness are not still clear, … |
HO CHEOL SHIN; | 2013-01-01 |
| 168 | Acceptance & Commitment Therapy for ME/CFS (Chronic Fatigue Syndrome) – An Open Case Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this research project is to evaluate if our well-researched behavior medicine treatment model for chronic pain, based on Acceptance and Commitment Therapy, is safe and effective in increasing quality of life and functioning also in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). To date there are no effective treatments for ME/CFS as the ethology and pathophysiology are unknown, while levels of functioning and quality of life as well as secondary effects such as depressive and anxiety symptoms indicate a highly affected patient population. As such, … |
RIKARD WICKSELL; | 2012-11-10 |
| 169 | Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Moderate and Serious Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME), Including in Patients With No Clinical Response After B-lymphocyte Depletion Using The Anti-CD20 Antibody Rituximab Related Papers Related Patents Related Grants Related Experts View Highlight: The hypothesis is that a subset of patients with chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME), including also patients with no clinical response after B-cell depletion therapy using the anti-CD20 antibody Rituximab, may benefit from tumor necrosis factor-alpha inhibition using Etanercept as weekly subcutaneous injections. |
ØYSTEIN FLUGE; | 2012-10-01 |
| 170 | Motor Control in Chronic Fatigue Syndrome and Fibromyalgia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project is a comprehensive study, with main focus on motor control, comparing patients with chronic fatigue syndrome / myalgic encephalopathy (CFS/ME) and/or fibromyalgia syndrome (FMS). Focus of the present project will be on detailed movement analysis in a movement laboratory and involve functional tasks such as walking and standing. Investigations will also comprise muscle activity, reaction time and fine motor control. |
NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY | 2012-09-01 |
| 171 | Chronic Fatigue Syndrome: Correction of Mitochondrial Dysfunction By Conditioning Exercise and Nutraceutical Therapy Related Papers Related Patents Related Grants Related Experts View Highlight: The pathogenesis of chronic fatigue syndrome (CFS) is poorly understood and no effective therapy has been developed. Recent studies suggest that a preceding viral infection causes mitochondrial dysfunction of the brain and skeletal muscle of genetically susceptible individuals. There is no specific laboratory test to identify patients with CFS. However, certain clinical manifestations are similar to those seen in mitochondrial disorders. Both patients with mitochondrial disorders and CFS manifest elevated serum lactate levels after exercise, and demonstrate elevated brain cerebrospinal fluid levels and decreased brain glutathione levels on nuclear magnetic resonance (NMR) spectroscopy. Therapy consisting of daily conditioning exercise, … |
ALFRED E SLONIM; | 2012-03-01 |
| 172 | Treatment of Multi-organ Bodily Distress Syndrome. A Randomized Controlled Trial of The Effects of Acceptance and Commitment Therapy Given As Group Therapy or Workshop Compared to Standard Treatment (Stress-4) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to test the effect of Acceptance and Commitment Therapy (ACT) in patients with long lasting health problems with no known medical explanation, defined as multi-organ Bodily distress syndrome (BDS). ACT treatment is given as two different types of treatment, a 9-session group therapy and a 1-day workshop followed by an individual consultation, and both are compared to standard treatment, which is one single advisory consultation. The study includes 180 patients. |
JOHANNE L AGGER; | 2012-01-25 |
| 173 | Treatment of Multi-organ Bodily Distress Syndrome. A Double-blinded Placebo Controlled Trial of The Effects of Imipramine (Stress-3) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to test the effect of the tricyclic antidepressant Imipramine in patients with longlasting health problems with no known medical explanation, defined as multi-organ Bodily distress syndrome (BDS). Pharmacological treatment of patients with BDS have never been tested, and Imipramine i low dosage (10-75 mg) has the potential of reducing both pain and other symptoms of bodily distress for patients with BDS. Control conditions are pill placebo. Study duration is 19 weeks for each of the 140 patients. End point is 13 weeks, i.e. after 10 weeks of 25-75 mg study drug. |
PER K FINK; | 2012-01-01 |
| 174 | Association of Membrane Polyunsaturated Fatty Acid Content and Intracellular Magnesium Concentration With Mental and Physical Symptoms in Fibromyalgia and SLE: A Case-control Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Polyunsaturated omega-3 fatty acids (ω3 PUFAs) are essential nutrients. Studies indicate that the incidence of Major Depression (MD) is inversely related to the consumption of fish (which are rich in ω3-PUFAs) and to the concentration of ω3 PUFAs in the plasma or Red Blood Cell (RBC) membranes. In several studies, the ω6 to ω3 ratio was elevated (ω6 PUFAs are pro-inflammatory, … |
JACOB N ABLIN; | 2011-11-01 |
| 175 | Assessment of Chronic Fatigue Syndrome As A Mitochondrial Disorder Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether therapy that has been shown to be beneficial for mitochondrial diseases is also beneficial for Chronic Fatigue Syndrome (CFS) patients. This study is a chart review of previous CFS patients who received daily conditioning exercise, a high protein diet and nutraceutical therapy (ENT). Prescribed nutraceutical supplements included alpha-lipoic acid, acetyl-L-carnitine, omega-3fatty acids (maxDHA), coenzyme Q10 (CoQ10), … |
ALFRED SLONIM; | 2011-11-01 |
| 176 | The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vitamin D3 is produced in the skin following exposure to UVB light from the sun or artificial sources, and occurs naturally in a small range of foods.More recently, several reports underlined the impact of vitamin D on the prevalence and consequences of inadequate vitamin D intake and the research supporting its benefits for alleviating chronic musculoskeletal pain and fatigue syndromes in outpatients. Experts have recommended that vitamin D inadequacy should be addressed in all patients with bone or joint pain, myalgia, fibromyalgia, … |
MEIR BENNUN; | 2011-09-01 |
| 177 | Pacing Activity Self-management for Patients With Chronic Fatigue Syndrome: Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Given the lack of evidence in support of pacing self-management for patients with chronic fatigue syndrome (CFS), it is examined whether physical behavior and health status of patients with CFS improve in response to a pacing self-management program. The effects of pacing will be compared with those observed when applying relaxation therapy to patients with CFS. |
JO NIJS; | 2011-08-01 |
| 178 | An Intervention to Improve Physical Activity in IBS Patients Has Long Term Positive Effects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Increased physical activity has in the investigators recent study been shown to improve symptoms in irritable bowel syndrome (IBS). The aim of this study was to assess the long term effects of the investigators previous intervention in IBS patients to improve physical activity. The investigators aimed to assess the long term effects on IBS symptoms as well as quality of life, fatigue, depression and anxiety. |
MAGNUS SIMRÉN; | 2011-06-01 |
| 179 | Coping With Chronic Fatigue Syndrome: Development of A Community-based Patient Education Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to develop, carry out, evaluate and measure the effects of a new patient education program for patients with Chronic Fatigue Syndrome (CFS)in primary healthcare. In an randomized controlled trial design the effects of the patient education program on coping, physical functioning, fatigue, pain, acceptance, anxiety, depression, quality of life, self- efficacy, and illness perception will be compared with treatment as usual. The results of the main project will lead to the elaboration of the final patient education program that can be implemented in primary health care, … |
UNNI SVEEN; | 2011-04-01 |
| 180 | Acupuncture for The Sleep Disorder of Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will conduct acupuncture for participants with chronic fatigue syndrome(CFS). Firstly the investigators aim to figure out the characteristic of sleep structure of CFS and the changes caused by acupuncture. Secondly the investigators seek to investigate the characteristic of sleep-wake rhythm, slow wave sleep(SWS)-rapid eye movement(REM)sleep rhythm, and REM sleep rhythm of CFS and the readjusting of acupuncture for it. Thirdly the investigators want to know the efficacy of acupuncture for relieving the fatigue, reducing accompanying symptoms and for improving the life quality of CFS. |
LI YING; | 2011-04-01 |
| 181 | Evaluation of Sleep Disordered Breathing and Autonomic Dysfunction in Fibromyalgia Through Peripheral Arterial Tonometry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Fibromyalgia syndrome (FMS) is characterized by the presence of widespread pain, chronic fatigue and typical sleep disturbances. The purpose of the current study is to investigate the nature of sleep disturbance in FMS, using a novel technology. Peripheral arterial tonometry is a method by which peripheral arterial tone is measured non – … |
JACOB N ABLIN; | 2011-01-01 |
| 182 | Kynurenine Pathway Metabolites As Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Irritable bowel syndrome (IBS) is a common disorder affecting up to 20% of the general population. Despite the prevalence of the disorder, it remains poorly understood. This is reflected in a symptom based diagnostic scheme, the lack of a suitable biological marker and inadequate treatment options. Current knowledge suggests the disorder is as a result of a dysregulated brain-gut axis, … |
GERARD CLARKE; | 2011-01-01 |
| 183 | Patient-Partner Stress Management Effects on CFS Symptoms and Neuroimmune Process PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test the effects of a videotelephone-delivered patient-partner dual-focused cognitive behavioral stress management intervention on chronic fatigue syndrome (CFS) symptoms and related psychosocial and neuroimmune processes in patients diagnosed with chronic fatigue syndrome. Study tests the hypothesis that videophone-delivered patient-partner cognitive behavioral stress management (T-PP-CBSM) intervention improves patient CFS symptoms relative to a videophone-delivered patient-partner Health Information (PP-T- HI) condition. |
MICHAEL H. ANTONI; | 2010-10-01 |
| 184 | B-lymphocyte Depletion Using The Monoclonal Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. An Open Label Phase II Study With Rituximab Induction and Maintenance Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Based on pilot patient observations, and experience from the prior study KTS-1-2008, the investigators anticipate that chronic fatigue syndrome patients may benefit from B-cell depletion therapy using Rituximab induction with maintenance treatment. The hypothesis is that at least a subset of CFS patients have an activated immune system involving B-lymphocytes, and that prolonged B-cell depletion may alleviate symptoms. |
OLAV MELLA; | 2010-10-01 |
| 185 | Humoral and Cellular Immune Responses After Influenza Vaccination in Patients With Postcancer Fatigue and in Patients With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Postcancer fatigue (PCF) is a frequently occurring, severe and invalidating problem, impairing quality of life. Patients with chronic fatigue syndrome (CFS) also suffer from severe fatigue symptoms. Although it is possible to effectively treat CFS, the nature of the underlying physiology remains unclear. The presence of an underlying immunological problem has been suggested as an explanation for PCF and CFS. The aim of this study is to compare the humoral and cellular immune responses upon influenza vaccination in PCF patients, CFS patients, non-fatigued cancer survivors, … |
H.W.M. VAN LAARHOVEN; | 2010-09-01 |
| 186 | Local Vasoconstriction in Postural Tachycardia Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in POTS and the mechanism(s) of POTS in individual patients. Specific causes for POTS may vary from patient to patient. Patients will be compared to healthy control subjects. There is a treatment arm with a medication (losartan) that reduces the binding of angiotensin and increases NO. If the investigators know the specific biochemical mechanism the investigators may be able to offer further specific treatments to specific patients. |
JULIAN STEWART; | 2010-07-01 |
| 187 | An Open-Label Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome Related Papers Related Patents Related Grants Related Experts View Highlight: A subset of patients suffering from chronic fatigue syndrome exhibit symptoms of neurally mediated hypotension. While the underlying pathophysiology of chronic fatigue syndrome is not precisely understood, a dysfunction of the autonomic nervous system is thought to play a role in this subset of patients. In several small studies, subjects within this subset have noted improvement in their chronic fatigue symptoms when treated for their neurally mediated hypotension. As droxidopa acts on the autonomic nervous system and has been shown to ameliorate symptoms of neurally mediated hypotension, … |
CHARLES W LAPP; | 2010-07-01 |
| 188 | B-lymphocyte Depletion Using The Monoclonal Anti-CD20 Antibody Rituximab in Severely Affected Chronic Fatigue Syndrome Patients. An Open Label Phase II Study With Rituximab Induction and Maintenance Treatment for Patients in WHO Performance Status III-IV Related Papers Related Patents Related Grants Related Experts View Highlight: Based on pilot patient observations, and experience from the prior study KTS-1-2008, the investigators anticipate that severely affected chronic fatigue syndrome patients may benefit from B-cell depletion therapy using Rituximab induction with maintenance treatment. The hypothesis is that at least a subset of chronic fatigue syndrome (CFS) patients have an activated immune system involving B-lymphocytes, and that prolonged B-cell depletion may alleviate symptoms. An approved amendment (April 15th 2011): the study will be extended with up to 5 patients. For up to 5 patients in the study, … |
OLAV MELLA; | 2010-06-01 |
| 189 | An Explorative Study on Physiological and Neurophysiological Determinants of Fatigue in Cancer Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Postcancer fatigue is a severe and invalidating problem, impairing quality of life. About 20 to 40% of the patients remain fatigued, at least one year after successful cancer treatment. Fortunately, there is an effective treatment for postcancer fatigue; cognitive behavior therapy. However, no cause for postcancer fatigue has been identified yet. The aim of the study is to identify factors that (partly) cause postcancer fatigue to improve the theoretical understanding of fatigue and to improve the diagnostics of fatigue, predict therapy outcome, and facilitate other treatment options. In this study, disease-free fatigued cancer patients, … |
H.W.M. VAN LAARHOVEN; | 2010-04-01 |
| 190 | The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study IS to – explore the underlying pathophysiology of chronic fatigue syndrome (CFS) in adolescents, particularly focusing on genetics, infections/immunology, endocrinology, autonomic control and cognitions – to assess the effect of clonidine (a drug that attenuates sympathetic nervous activity) in adolescent CFS. |
VEGARD BRUUN WYLLER; | 2010-02-01 |
| 191 | Use of Lisdexamfetamine Dimesylate in Treatment of Cognitive Impairment (Chronic Fatigue Syndrome): A Double Blind, Placebo Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Over the past decade, the Rochester Center for Behavioral Medicine (RCBM) has evaluated many patients with attention deficit hyperactivity disorder (ADHD). A recurrent finding in these patients is a history of unexplained fatigue and musculoskeletal pain. Treatment of these patients in our clinic has revealed that when their underlying ADHD is treated with psychostimulant medication, many patients report significant improvements with regard to their fatigue and musculoskeletal pain. Patients report less subjective fatigue and pain and note overall functional improvement, … |
JOEL L. YOUNG; | 2009-11-01 |
| 192 | A Pilot Study of Amygdala Retraining Program (ARP) Versus Control (C) in Patients With Chronic Fatigue Syndrome (CFS), Chronic Fatigue (CF) and Fibromyalgia (FM) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pilot study is to gather preliminary data on the efficacy and feasibility of the Amygdala Retraining Program (ARP), a mind-body practice versus a control (C) on fatigue, quality of life and sleep in patients with Chronic Fatigue Syndrome (CFS), Chronic Fatigue (CF) and Fibromyalgia (FM). CFS, CF and FM are incapacitating disorders characterized by profound fatigue, muscle pain, impaired memory, insomnia, and post-exertional malaise (Fukuda 1994). Current literature points to a centrally sensitized state in CFS, … |
ANN VINCENT; | 2009-10-01 |
| 193 | Acupuncture in The Treatment of Gulf War Illness PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This unblinded Phase II clinical trial tested the effects of individualized acupuncture treatments offered in extant acupuncture practices in the community; practitioners had at least 5 years of experience plus additional training provided by the study. Veterans with diagnosed symptoms of Gulf War Illness were randomized to either six months of biweekly acupuncture treatments (group 1, n=52) or 2 months of waitlist followed by weekly acupuncture treatments (group 2, n=52). Measurements were taken at baseline, 2, 4 and 6 months. The primary outcome is the SF-36 physical component scale score (SF-36P). |
LISA CONBOY; | 2009-07-01 |
| 194 | Treatment of Chronic Fatigue Syndrome and Fibromyalgia With D-ribose- A Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine whether adding Ribose 5 grams 3 x day would improve quality of life, energy, sleep and cognitive function and decrease pain in patients with CFS and/or fibromyalgia (CFS/FMS). |
JACOB E TEITELBAUM; | 2009-04-01 |
| 195 | Chronic Fatigue Syndrome and Abdominal Symptoms After Giardia Infection: Clinical Evaluation, Biomarkers, Risk Factors and The Effect of Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A giardiasis outbreak in Bergen has given us the opportunity to approach two basic research questions of national and global importance: – Studying the pathoimmunology of giardiasis in a natural setting, and following the genetic and immunological responses leading to recovery or persistent disease and sequelae. – Studying the two disease entities FGID and CFS when induced by acute giardiasi and their risk factors. – Interventional cognitive behavioural therapy is the only intervention documented to have significant effect on CFS outcome, … |
NINA LANGELAND; | 2009-03-01 |
| 196 | Fatigue Self- Management in Primary Care: Efficacy, Credibility, and Economics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate, in a primary care setting, the effectiveness of a brief self-management behavioral treatment in patients with medically unexplained chronic fatigue. The hypothesis will be tested that fatigue self-management will yield improvements in fatigue,functioning, and distress in comparison to the two control conditions: standard medical care alone or standard medical care plus an attention control symptom monitoring condition. |
FRED FRIEDBERG; | 2009-02-01 |
| 197 | B-cell Depletion Using The Monoclonal Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome. A Double-blind, Placebo-controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Based on pilot patient observations,the investigators anticipate that chronic fatigue syndrome (CFS) patients may benefit from B-cell depletion therapy. The hypothesis is that at least a subset of CFS patients have an activated immune system involving B-lymphocytes, and that B-cell depletion may alleviate symptoms. |
OLAV MELLA; | 2008-06-01 |
| 198 | Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work. |
CHANG H YEOM; | 2008-03-01 |
| 199 | Fatigue in Teenagers on The Internet (FitNet); Efficacy of Web-based Cognitive Behavioural Treatment for Adolescents With The Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine the efficacy of FITNET (web-based cognitive behavioural treatment) for adolescents with Chronic Fatigue Syndrome (CFS) in The Netherlands. The second goal of the study is to establish predictors of outcome. It is very important to know the characteristics of patients who will benefit from Cognitive Behavioural Treatment (CBT) and who will not. Possible predictors of outcome are: age, depression, anxiety, fatigue of the mother, parental bonding, self-efficacy, body consciousness of child and mother, physical activity (Actometer). |
E.M. VAN DE PUTTE; | 2008-01-01 |
| 200 | Behavioral Insomnia Therapy With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine how best to manage the sleep problems of people with Chronic Fatigue Syndrome. This study is being conducted to determine how improvements in sleep affect other Chronic Fatigue symptoms including pain, fatigue, and mood as well as a person’s sense of general well-being. |
MARK MAYO; | 2007-09-01 |
| 201 | Effects of Aerobic Exercise on Cognition, Mood and Fatigue Following TBI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine the efficacy of aerobic exercise for improving cognition, mood, and fatigue after Traumatic Brain Injury (TBI) as well as examine the role of Brain Derived Neurotropic Factor (BDNF) and peripheral Vascular Endothelial Growth Factor (VEGF) as mediators of response to exercise. |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2007-08-01 |
| 202 | Phase 1 Study of Immune, Psychometric and Sociodemographic Patterns in Pain Patients Classified By DSM-IV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to define subgroups of patients with somatoform disorders due to DSM-IV by immunological, psychological and genetic characterization. |
MANFRED WEISS; | 2007-08-01 |
| 203 | Identify Unique Set of Proteins in Cerebrospinal Fluid, Which Are Believed to Be Found in Chronic Fatigue Syndrome Participants, But Not in Healthy Controls PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is: 1. To identify specific set of proteins in the cerebrospinal fluid (fluid surrounding the brain and the spinal cord), that are believed to be seen in Chronic fatigue syndrome (CFS) patients, but not in healthy controls (HC). A similar study that the investigators had conducted before,suggested that significant changes in proteins in the cerebrospinal fluid may be due to the fundamental pathology of this disorder. 2. Increased cerebrospinal fluid pressure (pressure that helps the cerebrospinal fluid to move around the brain and the spinal cord), may be related with certain symptoms like headache, … |
JAMES BARANIUK; | 2007-07-01 |
| 204 | Phase IV – A Trial of Xyrem in The Treatment of Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic fatigue syndrome is a disabling illness for which there is no specific treatment. As a group, CFS patients have disturbed sleep with frequent arousals and the sense of not having slept upon awakening. Xyrem (Sodium oxybate) is known to improve deep sleep and so may reduce the sleep disturbances of CFS leading to better sleep with less fatigue. Its ability to produce the rapid onset of deep sleep is a reason it became a street drug, … |
BENJAMIN NATELSON; | 2007-05-01 |
| 205 | A Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate The Efficacy and Safety of Valganciclovir (Valcyte) in Patients Experiencing Chronic Fatigue Syndrome With Elevated Antibody Titers Against Human Herpesvirus-6 (HHV-6) and Epstein-Barr Virus (EBV) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study determine whether the drug valganciclovir has a significant and real benefit on the central core of symptoms experienced by patients who have high titers to EBV and HHV-6 and are experiencing long-standing fatigue and cognitive impairment (CFS). In addition, to characterize a quantifiable biological marker in these patients that will facilitate the identification of those likely to respond to valganciclovir and will make it possible to assess response to treatment. |
JOSE G MONTOYA; | 2007-05-01 |
| 206 | Autonomic Nervous System and Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators propose to test the hypothesis that the sympathetic nervous system contributes to the cardiovascular and inflammatory abnormalities present in the chronic fatigue syndrome (CFS) and, in particular in the subset of patients characterized by postural tachycardia syndrome (POTS). CFS and POTS are seen mostly in otherwise normal young women, and are the cause of significant disability. A substantial proportion of patients referred for evaluation of POTS met diagnostic criteria for CFS and, conversely, … |
ITALO BIAGGIONI; | 2007-04-01 |
| 207 | A Randomized Placebo-Controlled, Crossover-Design Study of The Effects of Low Dose Naltrexone on Quality of Life As Measured By The Multiple Sclerosis Quality of Life Inventory (MSQLI54) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized placebo-controlled, parallel-group study, crossover-design of the effects of low dose naltrexone on the multiple sclerosis quality of life inventory (MSQLI54) This study will assess the impact of LDN compared to placebo on quality of life as measured by the composite score of the MSQOL54 in adult subjects with MS. Also we plan: 1. To compare the 10 scales of the MSQOL54 during the active treatment and placebo cycles between active treatment and placebo groups 2. To compare each individual’s composite response to LDN versus placebo during the active treatment and placebo cycles 3. To compare each individual on the 10 scales of the MSQOL54 during the active treatment and placebo cycles |
BRUCE KORNYEYVA; | 2007-02-01 |
| 208 | Pilot, Opened, Randomized Clinical Trial to Assess The Efficacy of Duloxetine in The Treatment of Fibromialgy in Patients With Infection By HIV 1+ PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare duloxetine with conventional treatment of pain in HIV-1 infected patients. |
NEGREDO EUGENIA; | 2007-01-01 |
| 209 | Studies on Epstein-Barr Virus As A Possible Etiological Agent for Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (Chronic Fatigue Syndrome-CFS). Epstein Barr Virus is among the group of viruses that have been associated with a continuing fatigue for a long time with a number of symptoms occurring at the same time, but the cause is still unknown. |
GAILEN D MARSHALL; | 2007-01-01 |
| 210 | A Randomized, Placebo-Controlled, Double-Blind Trial of Duloxetine in The Treatment of Patients With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the safety and efficacy of duloxetine compared with placebo for reducing fatigue in patients diagnosed with Chronic Fatigue Syndrome (CFS). |
LESLEY M. ARNOLD; | 2006-09-01 |
| 211 | An Open-Label Study Of Poly I:Poly C12U (AMPLIGEN®) in Patients With Severely Debilitating Chronic Fatigue Syndrome (CFS) Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label study of Ampligen in patients with chronic fatigue syndrome. |
DANIEL PETERSON; | 2005-09-16 |
| 212 | Relationship of Autonomic Function to Hypnotic Susceptibility PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the relationship between susceptibility to hypnosis and regulation of the autonomic nervous system (nerves that control involuntary body functions, such as heart rate and sweating). Hypnosis is a state of mind in which the individual is highly focused, relatively unaware of his or her surroundings, and possibly more able to accept and use therapeutic suggestions. People vary in their responsiveness, or susceptibility, while in hypnosis. People with certain conditions, such as chronic fatigue syndrome (CFS), chronic pain, posttraumatic stress disorder (PTSD), … |
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE NINDS | 2003-05-01 |
| 213 | Phase 4 Study of The Use of Sildenafil (Viagra) to Alter Fatigue, Functional Status and Impaired Cerebral Blood Flow in Patients With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Use of Viagra to Alter Symptoms in Patients with Chronic Fatigue Syndrome (CFS) |
THEODORE FRIEDMAN; | 2002-07-01 |
| 214 | Massage Therapy for Cancer-Related Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop methods for studying the effect of bodywork therapy on symptoms of fatigue in patients undergoing cancer chemotherapy. |
ANDREW AVINS; | 2001-03-01 |
| 215 | Cardiovascular Hyporeactivity and Fatiguing Illness in Gulf War Veterans Related Papers Related Patents Related Grants Related Experts View Highlight: This research project is a follow-up to the prior VA-funded study that found that chronic fatigue reported by many Gulf War veterans may be a symptom of dysfunctional cardiovascular stress response regulation. Specifically, … |
US DEPARTMENT OF VETERANS AFFAIRS | 1999-10-01 |
| 216 | A Multi-center, Double-blind, Randomized, Placebo-controlled Study of The Safety and Efficacy of Poly I:Poly C12U (Ampligen®) 400 Mg IV Twice Weekly Versus Placebo in Patients With Severely Debilitating Chronic Fatigue Syndrome (CFS)/Myalgic Encephalomyelitis (ME) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: multi-center, double-blind, randomized, placebo-controlled study of the safety and efficacy. |
AIM IMMUNOTECH | 1998-12-01 |
| 217 | National Health Survey of Gulf War Era Veterans and Their Families – Phase III Physical Examinations PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Hypothesis: Gulf War veterans will have an equal prevalence or mean level of the following medical and psychological conditions frequently reported in the literature compared to a control group of nondeployed veterans: (1) chronic fatigue syndrome, (2) fibromyalgia, (3) post-traumatic stress disorder, (4) neurologic abnormalities, including peripheral neuropathy and cognitive dysfunction, and (5) general health status. |
US DEPARTMENT OF VETERANS AFFAIRS | 1998-11-01 |
| 218 | Essential Arterial Hypotension and Allostasis Registry PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The essential arterial hypotension and allostasis registry is a prospective, observational research that has the purpose of demonstrating that essential blood pressure (BP) disorders and the associated comorbidities are a result of the inappropriate allostatic response to daily life stress. This required a functioning brain orchestrating the evaluation of the threat and choosing the response, this is a mind-mediated phenomenon. If the response is excessive it contributes to high BP, if deficient to low BP, and the BP itself will identify the allostatic pattern, … |
LUIS EDUARDO MEDINA; | 1995-01-01 |