Clinical Digest: Recent Clinical Trials on Diabetes
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Diabetes. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Diabetes
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | The Validity of A Continuous Glucose Monitor in Diagnosing Gestational Diabetes: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective pilot study to assess the validity of using a continuous glucose monitor (CGM) in diagnosing gestational diabetes mellitus (GDM). Pregnant individuals between the ages of 18-50 years old receiving prenatal care at Mount Sinai Hospital (e..g, E-Level clinic and Faculty Practice Associates) will be enrolled. Potential participants will be approached during their prenatal care appointments. Participants will complete an informed consent form for the study during their standard-of-care prenatal appointments at our institution. |
ANGELA BIANCO; | 2025-05-01 |
| 2 | Effects of Neuromuscular Electrical Stimulation and Aerobic and Resistance Exercise on Glycemic Control in Older Adults With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effects of neuromuscular electrical stimulation (NMES), aerobic and resistance exercise, and health literacy intervention on fasting glucose levels and quality of life in older adults with type 2 diabetes (T2DM). Given the growing prevalence of T2DM in aging populations and the associated health risks, identifying effective interventions is crucial. The randomized controlled trial (RCT) will include participants aged 60+ with T2DM, randomly assigned to one of three groups: NMES, structured exercise, or a health literacy control group. Outcomes will be assessed at baseline, post-intervention (12 weeks), and follow-up (30, 60, … |
CARLOS TAVARES; | 2025-05-01 |
| 3 | A Phase 1 Study to Assess The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4057996 in Healthy Participants and Participants With Type 1 and Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate how well LY4057996 is tolerated and what side effects may occur in healthy participants and participants with Type 1 and Type 2 Diabetes. The study drug will be administered either subcutaneously (SC) (under the skin) or intravenously (IV) (into a vein in the arm). Blood tests will be performed to check how much LY4057996 gets into the bloodstream and how long it takes the body to eliminate it. The study will last 11 weeks for Part A1-A2, 4 weeks for A3-A5, 5 weeks for Part B and 7 weeks for Part C, … |
ELI LILLY | 2025-05-01 |
| 4 | Aiming for Something Sweeter: Supporting Youth with Type 1 Diabetes During Transition from Pediatric to Adult Diabetes Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional study is to assess the effects and evaluate the implementation of a pediatric to adult care transition intervention in youth with T1D on clinical, patient-reported, and implementation outcomes, including an economic analysis. The 3 main aims are: 1. To assess the effects of our transition intervention on clinical and patient-reported outcomes. 2. To implement the transition intervention and evaluate the implementation outcomes. 3. To evaluate the economic impacts of the transition intervention. Participants will have access to a transition coordinator before, during, … |
SONIA BUTALIA; | 2025-05-01 |
| 5 | Adapting An Adolescent Weight Management Program for A Type 1 Diabetes Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Before the 1990s, obesity was rare among young people with type 1 diabetes (T1D), but now it is more common. Recent studies show that over 50% of young people with T1D will have overweight or obesity within five years of being diagnosed with T1D. Both obesity and T1D increase the risk of heart disease, and combined, these risks are even higher. Intensive health behavior and lifestyle treatments (IHBLTs) are proven to be effective for treating childhood obesity. However, managing T1D creates unique challenges that require adjustments to these treatments. For example, … |
JENNY WARNICK; | 2025-05-01 |
| 6 | ATP (Adenosine Triphosphate) Concentration Measurement By Phosphorus-31 Spectroscopy in Phosphate Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Phosphate diabetes is defined by urinary phosphate wasting due to impaired tubular reabsorption. It can be classified based on either a genetic or acquired origin. Chronic hypophosphatemia causes rickets in children, leading to growth disorders, bone deformities, and bone pain. In adults, it results in osteomalacia, pseudofractures, as well as muscle fatigue and weakness during exertion. X-linked hypophosphatemia (XLH) is a common cause of hereditary rickets linked to renal phosphate loss due to elevated FGF23 levels, … |
HOSPICES CIVILS DE LYON | 2025-05-01 |
| 7 | Randomized Control Trial Evaluating The Impact of Continuous Glucose Monitoring Academy Education Curriculum Versus Standard Care on Glycemic Outcomes for Youth With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the Impact of Continuous Glucose Monitoring Academy Education Curriculum Versus Standard Care on Glycemic Outcomes for Youth With Type 2 Diabetes (T2D): * The first aim is to determine how feasible it is to adapt the Continuous Glucose Monitoring Academy curriculum to teach youth with T2D glucose management strategies. * The second aim is to evaluate the effects of the Continuous Glucose Monitoring Academy metrics. * The third aim is to explore the relationships between these metrics with diabetes distress, diabetes family responsibilities, … |
REBECCA BARBER; | 2025-05-01 |
| 8 | Randomized Control Trial Evaluating The Impact of CGM Academy Education Curriculum Versus Standard Care on Glycemic Outcomes for Youth With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to compare the effects of a virtual education curriculum in blood glucose variation of youth with type 1 diabetes wearing continuous glucose monitoring (CGM) device. The main questions the study aims to answer are: * Do participants undertaking the proposed curriculum present improved glucose variation than participants of standard education? * Explore relationships between participant’s glycemic outcomes with diabetes distress, diabetes family responsibilities, … |
REBECCA BARBER; | 2025-05-01 |
| 9 | Groceries Plus Multi-Component Lifestyle Intervention for Adults With Hypertension and Type 2 Diabetes Residing in Urban Food Deserts (DASH-Life): Pilot Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: People with high blood pressure and diabetes often have low levels of key nutrients as a result of not eating enough fresh fruits and vegetables. Research studies suggest that these nutrients can lower blood pressure and blood sugar. This study will investigate if providing encouragement to adopt this healthy and nutritious way of eating and providing guidance on weight management will lower blood pressure and blood sugar. The DASH-Life research study will recruit adults with hypertension and type 2 diabetes who live in Baltimore metro areas that don’t have many stores selling healthy foods. The DASH-Life research study is 6 months long. Participants will be randomly assigned to one of two groups: 1) Self-Shopping DASH (S-DASH) diet advice group, or 2) Coaching DASH (C-DASH) diet advice group. |
JESSICA YEH; | 2025-05-01 |
| 10 | A Randomized, Investigator- and Participant-blinded, Multiple-ascending Dose, Placebo-controlled Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3549492 in Japanese Participants With Type 2 Diabetes Mellitus and Healthy Japanese Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate how well LY3549492 is tolerated and what side effects may occur in Japanese participants with Type 2 Diabetes Mellitus (T2D) and healthy Japanese participants. The study drug will be administered orally. Blood tests will be performed to check how much LY3549492 gets into the bloodstream and how long it takes the body to eliminate it. The study will last up to approximately 19 weeks for both Part A (Cohorts 1-3) for multiple-ascending doses (MAD), and Part B (Cohorts 4-5) multiple-ascending doses (MAD), for a total of approximately 25 weeks, including screening. |
YASUKO OWADA; | 2025-05-01 |
| 11 | Bringing Advocacy Via Digital Guide to The Emergency Department (Project BADGE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The pilot study of Project BADGE will focus on emergency department (ED) patients with diabetes, which has significant disparities in prevalence and mortality for underserved populations. The objective is to determine the effect of a text-based resource referral platform with diabetes educational materials on patient diabetes knowledge, diabetes distress, diabetes self-care activities, and acceptability and feasibility of the intervention. |
SARA HEINERT; | 2025-05-01 |
| 12 | Growth Hormone Resistance of Beta-cells in Women With Gestational Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes. |
BETTINA MITTENDORFER; | 2025-05-01 |
| 13 | Scaling Up Community-based Noncommunicable Disease Research Into Practice in Pokhara Metropolitan City of Nepal PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate whether a multifaceted community-based intervention, comprising 1) screening and lifestyle counseling by female community health volunteers (FCHVs); community health workers in Nepal, through home visits, and 2) regular Short Message Service (SMS) messages, can effectively reduce systolic blood pressure (SBP), lower fasting blood glucose, and increase smoking cessation rates among adults living in Pokhara with hypertension, type 2 diabetes, and smoking habits, … |
DINESH NEUPANE; | 2025-04-30 |
| 14 | Targeting Beta-cell Function to Achieve Remission of Type 2 Diabetes (REACTIVATE). An Open-label, Single-centre, Randomised, Parallel Study to Assess The Efficacy, Safety and Utility of Fully Closed-loop Insulin Delivery in Achieving Remission of Diabetes Compared to Standard Therapy With A Glucose Sensor in Adults With Recent Onset Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the REACTIVATE study is to investigate whether a period of intensive insulin therapy using closed-loop technology, when combined with diet and lifestyle education, can restore beta-cell function and achieve remission of recent-onset type 2 diabetes. This is a single-centre, open-label, randomised, parallel design study comparing up to 12 weeks of fully closed-loop insulin delivery to standard care with a glucose sensor in adults with recent-onset type 2 diabetes. The primary outcome is the number of participants achieving remission of diabetes at 52 weeks, … |
CHARLOTTE BOUGHTON; | 2025-04-24 |
| 15 | A Randomized, Double-Blind, Phase 2 Trial of Once-Weekly Petrelintide Compared With Placebo in Participants With Overweight or Obesity and Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to investigate efficacy and safety of three doses of petrelintide versus placebo in participants with overweight or obesity and type 2 diabetes. |
ZEALAND PHARMA | 2025-04-21 |
| 16 | Meal Frequency, Glycemic Control and Variability in Individuals With Type 1 Diabetes: A Randomized Crossover Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effect of 3 versus 6 daily meals of isocaloric diets on glycemic control and variability in individuals with type 1 diabetes. Participants will be randomized in a crossover clinical trial and will receive two different types of isocaloric diet interventions, in 3 meals/day (calorie distribution: 30% at breakfast, 40% at lunch and 30% at dinner) or 6 meals/day (calorie distribution: 20% at breakfast, 10% at morning snack, 30% at lunch, 10% at afternoon snack, 25% at dinner and 5% at evening snack), for three weeks, … |
FERNANDO GERCHMAN; | 2025-04-20 |
| 17 | Impact of Integrated Pet Care on Glycemic Control and Diabetes Responsibility PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if incorporating the structured care of a pet fish into a family-based diabetes self-care routine combined with communication skills training works to improve glycemic control, blood glucose monitoring frequency and blood glucose review in early adolescents with suboptimal control of type 1 diabetes. |
OLGA GUPTA; | 2025-04-16 |
| 18 | Implementation PRogram to Improve Screening and Management for CKD in Diabetes (Program 2) (IRIS-CKD) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: IRIS-CKD is a two-program implementation study to improve guideline-recommended screening and treatment of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States. |
NEHA PAGIDIPATI; | 2025-04-15 |
| 19 | Implementation PRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: IRIS-CKD is an implementation study to improve guideline-recommended screening of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States. |
NEHA PAGIDIPATI; | 2025-04-15 |
| 20 | Mechanisms Underlying The Relationship Between Sleep and Circadian Health and Cardiometabolic Risk in Adolescents With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Research has shown a link between poor sleep health and late circadian timing with cardiometabolic health in adolescents with type 1 diabetes (T1D). Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in T1D, which begins as early as adolescence, and current therapies are limited. Therefore, this study plans to investigate whether cardiometabolic health can be improved with increased sleep duration and advanced circadian timing in adolescents with T1D with habitually insufficient sleep. To answer this question, investigators will study adolescents with T1D who get \<7h sleep on school nights and measure changes in insulin sensitivity, glycemic control, … |
STACEY L SIMON; | 2025-04-15 |
| 21 | Effects of Prediabetes and Type 2 Diabetes on Cognitive Status, Physical Function, and Fatigue in Geriatric Individuals: A Case-Control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This case-control study will evaluate the effects of geriatric individuals on cognitive status, physical function and fatigue. Our study aims to compare the effects of geriatric individuals with prediabetes and type 2 diabetes with healthy geriatric individuals on cognitive status, physical function and fatigue. Accordingly, … |
KEVSER GÜRSAN; | 2025-04-15 |
| 22 | The Impact of Gestational Diabetes Mellitus on Cerebral Blood Flow and Cerebrovascular Function After Pregnancy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Gestational Diabetes Mellitus (GDM) currently affects approximately 14% of all pregnancies worldwide. Importantly, the health-related consequences of GDM extend well beyond pregnancy, such that women with a history of GDM have a 40% increased risk of cerebrovascular diseases and a 67% increased risk of dementia, compared to women with a history of uncomplicated pregnancy. Women with a history of GDM have impaired skin microvascular function, compared with women with a history of uncomplicated pregnancy. Therefore, it’s likely that GDM results in impaired brain blood vessel function, … |
ANNA STANHEWICZ; | 2025-04-15 |
| 23 | INHALE-AIDEx: A Randomized Crossover Trial Evaluating The Effect of Inhaled Technosphere Insulin (Afrezza®) Vs Rapid Acting Analogue Insulin on Exercise-Induced Hypoglycemia in Adults With Type 1 Diabetes Using Automated Insulin Delivery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This investigator-initiated study will enroll about 30 adults 18 to 60 years of age with type 1 diabetes (T1D) who are using the Tandem t:slim X2 insulin pump with Control-IQ technology (Control-IQ). The study is being done to find out if inhaled insulin given for a meal is safer and better to use than a bolus of insulin through your pump when you exercise following a meal. Participants are asked to complete three study exercise visits in the clinic. |
MICHAEL R RICKELS; | 2025-04-15 |
| 24 | Improving Outcomes in Pediatric Diabetes: Building The Evidence Base to Inform Effective Diabetes Technology Interventions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Youth with public insurance underutilize diabetes care, particularly diabetes technology which is associated with improvement in diabetes-specific outcomes. Thus, we urgently need studies to understand and increase diabetes technology utilization. This proposed research will (1) improve representation of youth in the literature, (2) address the gap in knowledge of barriers and promoters in youth, and (3) identify and address factors associated with diabetes technology uptake and utilization. |
ANANTA ADDALA; | 2025-04-15 |
| 25 | Combined Effect of High Intensity Interval Training and Ultrasound Cavitation on Lipid Profile in Type 2 Diabetes Patients With Abdominal Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aim to find out the combined effect of high intensity interval training and ultrasound cavitation on lipid profile in type two diabetic patient with abdominal obesity. |
MAHMOUD AWAD RAMADAN ELKHOLY; | 2025-04-11 |
| 26 | A Phase 1/2 Adaptive Dose Study to Evaluate The Safety and Efficacy of SR-02 Pancreatic Endocrine Cell Clusters Implanted in The Omentum of Adults With Type 1 Diabetes Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the safety, efficacy and durability of SR-02 administered to the omentum of patients of Type 1 diabetes with severe recurrent hypoglycemia. The study will also help establish the optimal treatment dose. Although this study is open to patients with all HLA or blood types, immunosuppression to prevent rejection will be required in this first in human study. |
SERAXIS | 2025-04-10 |
| 27 | The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The EAGER pilot trial is designed to assess the feasibility of a Canadian, multicentre prospective randomized open-label blinded end-point (PROBE) clinical trial addressing whether induction of labour (IOL) at 38 weeks’ gestation compared to expectant management (EM) reduces severe perinatal mortality and morbidity among individuals with gestational diabetes mellitus (GDM). Eligible participants will be recruited between 36 weeks + 0 days and 38 weeks + 0 days gestation. Participants will be randomized to one of two arms: * Intervention Arm: IOL between 38 weeks + 0 days and 38 weeks + 6 days OR * Control Arm: EM without intervention until spontaneous labour, or earlier if a medical indication arises. A total of 260 participants (130 per group) will be recruited from Canadian sites, where participants will have 3 study visits: 1. Enrollment and randomization 2. After delivery and up to 72 hours postpartum 3. 6 weeks postpartum At enrollment and randomization, patient-reported baseline and clinical data from medical charts will be collected. Upon admission to hospital for labour and delivery, a blood sample will be collected to assess HbA1C and plasma glucose levels. After delivery and up to 72 hours postpartum, study feasibility will be assessed through patient-reported outcomes and administrative and clinical data. At 6 weeks postpartum, participants will be surveyed for secondary health resource use. Findings from this pilot will inform the design, implementation and feasibility of a future full-scale randomized controlled trial. |
MARK C WALKER; | 2025-04-07 |
| 28 | Optimizing Care for Diabetic Patients in Hospitalized Rehabilitation Through Structured Education PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A large number of patients at the Neurological and Functional Rehabilitation Centre of the University Hospital of Liège have associated pathologies, including diabetes. These patients may have diabetes-related complications that require recurrent hospitalizations in an acute structure or in rehabilitation. One of the ways to limit complications is to set up patient education. 1. Objectives * To compare the impact of management through formal education with that of awareness. * To evaluate the impact on knowledge of structured education. * To evaluate the impact of structured education on the quality of life experienced by diabetic patients. * Identify the patient’s level of satisfaction with the education sessions. * To evaluate the impact of structured education on the biological improvement of glycated hemoglobin. * To evaluate the impact of structured education on diabetes-related complications. 2. Working Hypothesis The implementation of structured diabetes education allows patients to acquire, or maintain, the skills they need to manage their lives as well as possible despite the constraints of chronic disease… . 3. Study population All diabetic patients hospitalized in all care units. 4. Collection tools and techniques Collection tools 1. Diabetes Knowledge Questionnaire. 2. SF-36 Health Questionnaire. 3. Satisfaction questionnaire for structured sessions on diabetes. 4. Questionnaire to identify complications and/or re-hospitalizations after your stay in rehabilitation. Collection technology At admission (D+1) * Validation of inclusion and exclusion criteria. * Submission and distribution of the information and consent form. * Obtaining informed consent from the patient. * Distribution of collection tools 1 and 2 (collection on D+2). * Control of glycated hemoglobin. At the end of hospitalization (D-2) * Distribution of collection tools 1, 2 and 3 on D-2 before the release (collection on D-1). * Control of glycated hemoglobin. 3 months after the end of hospitalization * Sending collection tools 1, 2 and 4 by post. The patient will be invited to complete them and return them by post. * The patient will be invited to take a blood test for glycated hemoglobin. |
HELENA CASSOL; | 2025-04-07 |
| 29 | The SWITCH (Substitution of High With Low Ultra-processed Soy Protein Foods In A Guideline-based Diet InTervention for Cardiometabolic Health) Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, controlled, parallel study with 3 experimental arms aimed to assess the effect of a digital dietary intervention (web-based app, online behavior change curriculum) enhanced with 10 servings of vegetables and fruit (5 as dietary advice within the app, 5 within a dehydrated vegetable and fruit blend), with or without high Ultra Processed Food (UPF) soy-containing proteins compared to standard of care (usual care) on systolic blood pressure (SBP; primary outcome), and other key cardiometabolic endpoints over 12-weeks in adults living with hypertension and obesity, … |
LAURA CHIAVAROLI; | 2025-04-07 |
| 30 | Continuous Glucose Monitoring-Assisted Remote E-health Dietetics to Empower People with Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A parallel, single-blinded, randomised clinical trial conducted remotely across Australia from the Mary MacKillop Institute for Health Research (MMIHR, Australian Catholic University) for individuals with type 2 diabetes, by researchers from Australian Catholic University, University of Adelaide, University of Queensland, University of Wollongong, Monash University, Monash Partners, Deakin University, La Trobe University and Melbourne University. |
EVELYN PARR; | 2025-04-07 |
| 31 | Study of The Prevalence of Diabetes and Pre-diabetes in Réunion Island PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: In view of the new priority given to diabetes in Réunion and the implementation of an ambitious plan to combat the disease at regional level, which includes the identification and management of pre-diabetes, the need for up-to-date data on the extent of these 2 diseases (diabetes and pre-diabetes) has become essential. These two diseases have known risk factors: age, overweight, obesity, high waist circumference, family history, hypertension, eating habits and physical activity, … |
CATHERINE MARIMOUTOU; | 2025-04-02 |
| 32 | Effects of Repeated Dose of Dorzagliatin on Insulin Secretion, Glucagon Release and Incretin Function in Intermediate Hyperglycemia and Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A total of 30 subjects will be recruited 15 with intermediate hyperglycemia and 15 in the tyep 2 diabetes group respectively. Eligible participants will undergo hyperglycemic-clamp/oral glucose tolerance at baseline and after 4 weeks of dorzagliatin treatment. |
ELAINE CHOW; | 2025-04-02 |
| 33 | Association Between Mild Fetal Hydronephrosis (G1-G2), Gestational Diabetes and Spontaneous Resolution in The First Year of Life Vs Moderate-severe Fetal Hydronephrosis (G3-G4), Obstructive Causes and Worse Postnatal Outcome PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Renal pelvis dilatation can be a relatively common finding on obstetric antenatal ultrasounds occurring in 1% to 5% of all pregnancies, with a known predilection for the male sex. Fetal hydronephrosis can be ascribed to structural obstructive conditions or functional origin causes. The latter are characterized by the transience of the clinical picture, which appears milder in degree, onset at later gestational ages, a course of substantial stability and spontaneous regression, sometimes as early as during pregnancy or early postnatal life. Fetal hydronephrosis related to structural obstructive causes, on the other hand, classically presents an earlier onset, … |
ANITA ROMITI; | 2025-04-01 |
| 34 | Single-blinded, Double-arm, Controlled, Randomized, Multicentre Clinical Trial to Evaluate The Impact of Pharmacogenetic-guided Treatment in Patients With Insufficiently Controlled Type 2 Diabetes PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the efficacy of a pharmacogenetics-guided treatment, compared to standard optimized treatment, in patients with inadequately controlled type 2 diabetes. The main questions it aims to answer are: * Is the disease better controlled when the treatment prescribed is based on the participant’s pharmacogenetic profile? * What medical problems do participants experience while taking the treatment? Participants will: * Take the treatment described according to the Summary of Product Characteristics (SmPC). * Visit the clinic once every 12 weeks for checkups and tests. * Keep a diary of their symptoms to inform the Investigator. |
SERGIO MARTÍNEZ HERVÁS; | 2025-04-01 |
| 35 | A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Evaluating The Efficacy and Safety of Tirzepatide Once Weekly Compared to Placebo in Adult Participants With Type 1 Diabetes and Obesity or Overweight PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to find out how well and how safely tirzepatide works in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 49 weeks. |
KRISTIN CASTORINO; | 2025-04-01 |
| 36 | Population Health Management for Kaiser Permanente Northern California (KPNC) Members With Newly Diagnosed Diabetes: A Randomized Trial of A Proactive and Augmented Initial Care Strategy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a 2-arm randomized trial of Augmented Initial Type 2 Diabetes (T2D) Care vs. Usual Initial T2D Care among adults (18-74 years) with newly diagnosed T2D who have risk factors (defined by age and diagnosis HbA1c value) for suboptimal early glycemic control. Augmented Initial T2D Care comprises the elements of usual care augmented by more proactive and intensive outreach from the diabetes care team. The study team will use electronic health record (EHR) data to assess between-arm differences in diabetes-related outcomes at 6- and 12 months. |
KAISER PERMANENTE | 2025-04-01 |
| 37 | Trajectories in Insulin Sensitivity Across Menstrual Cycles in Women With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Standardized longitudinal data collection of diabetes management relevant factors in women with T1D (insulin requirements, glucose variability, nutritional information, and menstrual cycle information) to identify categories of cycle trajectories. |
DCB RESEARCH AG | 2025-04-01 |
| 38 | Integrating Diabetes Care Into Primary Healthcare Centers in Abuja, Nigeria: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study, Integrating diabetes care into Primary Healthcare Centers (PHCs) in Abuja, Nigeria: a pilot study, is to screen, diagnose, treat, and educate diabetes patients in two selected PHCs in Abuja. This single-arm pilot trial will test the feasibility of integrated diabetes care, measure the implementation outcomes, and explore the effectiveness of the strategy bundle using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. |
IKECHUKWU ANTHONY ORJI; | 2025-04-01 |
| 39 | Association Between CGM Metrics in Type 2 Diabetes Pregnancy and Perinatal Morbidity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this observational study is to measure the association between continuous glucose monitoring (CGM) parameters and perinatal morbidity in offspring of women with type 2 diabetes. Specifically, the study will assess whether gestational age interacts with metabolic control in influencing perinatal morbidity, as well as the impact of the timing of CGM initiation during pregnancy. |
CORALIE AMADOU; | 2025-04-01 |
| 40 | Effect of Empagliflozin on Quality of Life in Chronic Heart Failure Patients With Diabetes Mellitus Type II PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Effect of Empagliflozin on Quality of Life in patient of Chronic Heart Failure with Diabetes Mellitus Type II. As per ESC Guidelines Empagliflozin is recommended as part of the first-line treatment for HFrEF, irrespective of diabetes status. As per American College of Cardiology (ACC)/American Heart Association (AHA) Empagliflozin is recommended in both diabetic and non-diabetic HF (especially beneficial in patients with HFrEF and HFpEF). The aim of my study is to assess the impact of Empagliflozin on quality of life in Pakistani patients, considering the genetic, … |
TOOBA RIAZ; | 2025-04-01 |
| 41 | Evidence-informed Trial of Lifestyle Interventions to Improve Glycemic Parameters and Reduce Gestational Diabetes in High-risk Pregnant Individuals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is assess the impact of a higher intensity dietary and activity counseling program to improve blood sugar control and reduce the chance of developing gestational diabetes (GDM) as compared to the current standard diet and activity counseling. |
DAVID HAAS; | 2025-04-01 |
| 42 | Student Pharmacist Intervention on Type 2 Diabetes Management in Older Adult Populations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to assess the impact of student pharmacist involvement on blood glucose control through non-pharmacological interventions in people of Asian and Asian descent over the age of 50 with type 2 diabetes. This study team is trying to advance the field of pharmacy and expand the roles of student pharmacists. |
CRYSTAL ZHOU; | 2025-04-01 |
| 43 | The Effect of Web-Based and Artificial Intelligence-Assisted Personalized Applications on Knowledge Levels Compliance with Treatment and Self-Management Among Diabetic Individuals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients in the AI-supported mobile application group will be able to log in with a username and password that will be defined specifically for them. Patients will be informed about how the application is used during their first interview. They will enter their personal and disease characteristics (age, gender, height, weight, HbA1C, HDL, LDL) into the application at the entrance. Other sections of the application will include exercise, nutrition, medication tracking, complication tracking and diabetic foot care sections. The person will be asked to enter relevant information in these fields according to their own life and condition (for example; … |
NILHAN TOYER SAHIN; | 2025-04-01 |
| 44 | A Single-Dose and Multiple-Ascending Dose Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the safety, tolerability of LY4086940 and how it is processed in the body. Participation in Part A of the study will last about 10 weeks and may include up to 6 visits. Participation in Parts B, C, D will last approximately 15 weeks and may include up to 9 visits. |
HUGH COLEMAN; | 2025-04-01 |
| 45 | National Forsøgsordning Med Glukosesensorer Til Type 2-diabetes: Glukosesensorer Til Gravide Med Type 2-diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the use of glucose sensors in pregnant women with type 2 diabetes to improve insulin regulation, pregnancy and birth outcomes, … |
ODENSE UNIVERSITY HOSPITAL | 2025-04-01 |
| 46 | Assessing The Effect of Advanced Hybrid Closed Loop System, MiniMed 780G With GS4 Glucose Sensor in Newly Diagnosed Children and Adolescents With Type 1 Diabetes on Glycemic Control and Patient Reported Outcomes Compared to Standard Insulin Therapy Historical Data (AHCL in New Onset T1D Children Study): A Single Arm Open- Label Prospective Observational Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate glycemic control of users of the AHCL system MiniMed 780G with GS4 calibration-free sensor in children and adolescents with newly diagnosed T1D implemented directly upon T1D diagnosis in combination with continuous glucose monitoring system (CGMS) compared with those treated with MDI retrieved from historical data- in a single- arm open-label prospective observational study, assessed at 3 months. After the initial study period there will be a 3month extension phase of the study. |
CHRISTINA KANAKA-GANTENBEIN; | 2025-04-01 |
| 47 | A Phase 1b/2a Double Blind, Placebo Controlled Study to Evaluate The Safety, Tolerability, Pharmacodynamics, and Efficacy of CNP-103 in Subjects Ages 12-35 with Recent Onset Stage 3 Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-103. The approximately 208-day study consists of a Screening Period (28 days), Treatment Period (90 days), and Post-Dose Evaluations (90 days). |
COUR PHARMACEUTICAL DEVELOPMENT COMPANY | 2025-04-01 |
| 48 | The Effect of Fully Closed-loop Insulin Delivery on Renal Oxygenation in People With Type 2 Diabetes and Chronic Kidney Disease: An Open-label, Single-center, Randomized Two-arm Parallel Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to evaluate the effect of fully automated closed-loop glucose control on renal tissue oxygenation among people with type 2 diabetes and stage 3 chronic kidney disease. This is a single-center, open-label parallel design study that will compare 26 weeks of fully-automated closed-loop glucose control with standard insulin therapy and continuous glucose monitoring, … |
HEBA AL-ALWAN; | 2025-04-01 |
| 49 | Validation of NOURISH Project’s Culturally Tailored Meals on Postprandial Glycemic Response Using Continuous Glucose Monitoring: A Quantitative and Qualitative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are hoping to determine whether tailoring the diet of someone with type 2 diabetes to their ethnic group while following American Diabetes Association guidelines can make a significant difference in their blood sugar controls. Participants will be required to wear a Continuous Glucose Monitor (CGM) for 1-month so that the investigators can compare blood sugar levels when participants are eating their routine diet vs. the culturally tailored diabetes diet. |
MINAL MOHARIR; | 2025-04-01 |
| 50 | Immunomodulatory and Therapeutic Efficacy of 5-methyltetrahydrofolate Supplementation on Autoimmune Status in Type 1 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the improvement of autoimmune status in patients with Type 1 Diabetes (T1D) through supplementation with 5-Methyltetrahydrofolate, and to explore the safety and efficacy of this treatment. The research seeks to provide new methods for the treatment of T1D and offer innovative ideas for enhancing the quality of life of T1D patients. |
SHANGHAI CHANGZHENG HOSPITAL | 2025-04-01 |
| 51 | A Phase I/IIa, Single Site, Open-Label, Ascending Dose Study to Evaluate The Safety and Efficacy of OPF-310 [Encapsulated Porcine Islet Cells for Xenotransplantation] in Subjects With Type 1 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the recommended Phase 2 dose (RP2D) in adult subjects with unstable Type 1 Diabetes Mellitus (T1DM) and a level 3 (severe) hypoglycemic episode at least three times within the 1 year prior to enrollment despite treatment with a closed loop system (CLS) for at least 6 months. |
OTSUKA PHARMACEUTICAL FACTORY | 2025-04-01 |
| 52 | Autologous Insulin Producing Mesenchymal Stem Cell Transplantation in Youth With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 1 Diabetes is a chronic autoimmune disease. It results from autoimmune destruction of pancreatic Beta cells leading to absolute insulin insufficiency. The establishment of pluripotent like human stem cells derived from adipose tissue derived mesenchymal cell origin have introduced a new potential source for cell therapy in type 1 diabetic patients, especially in light of recent successes in producing glucose-sensitive insulin secreting cells and this will be the scope of this study. In the last decade, human clinical trials of introducing insulin producing stem cells from various origins were approved and conducted. |
RASHA S ELMETWALLY; | 2025-04-01 |
| 53 | Diabetes Prediction During Pregnancy Using Pancreas MRI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Previous studies have shown that pancreas size tends to be smaller in individuals with diabetes compared to those without diabetes. The investigators have recently found that pancreas size increases during pregnancy. The MAMA study aims to examine changes in the pancreas that occur during pregnancy, in both pregnant mothers and their babies, and find out how they are affected by maternal diabetes. The MAMA study is a prospective cohort study that will follow women and their babies through pregnancy and one year postpartum. Women aged 18-54, … |
JOHN VIROSTKO; | 2025-04-01 |
| 54 | Empowering Adults With Diabetes: Achieving Self-management Success Through Data-Driven Behavior Change, Pilot Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Day-to-day self-management by adults with type 2 diabetes, including glucose monitoring, taking medications, and healthy habits, is essential to avoid diabetes complications, yet, despite the rapidly expanding availability of wearable glucose and activity monitors, successful self-management remains challenging for many. This research aims to develop and test an approach to help adults use their personal diabetes information from wearable devices to achieve and sustain health diabetes self-management, which will reduce diabetes complications, and improve health and quality of life for people with type 2 diabetes. |
ANN-MARIE ROSLAND; | 2025-04-01 |
| 55 | Diabetes Electronic Prompt for Improved Care Coordination and Treatment (DEPICCT) in The ED PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to improve the processes of Type 2 Diabetes (T2D) care coordination and treatment in the emergency department (ED) by utilizing clinical decision support mechanisms in the electronic health record (EHR). The main question is whether electronic prompts triggered by hyperglycemia and elevated A1c results in providers providing earlier treatments and faster time to subsequent primary care appointment and greater reduction in hemoglobin A1c (HA1c). ED clinicians will receive alerts called Our Practice Advisories (OPA’s) through the EPIC EHR. The 1st OPA triggers when a random point-of-care (POC) glucose is ≥250 mg/dL, … |
PAUL PENG; | 2025-03-30 |
| 56 | Efficacy and Safety Comparison of Cofrogliptin Add-on Versus Metformin Dose-escalation in Type 2 Diabetes Patients Inadequately Controlled With SGLT-2 Inhibitors Plus Low-Dose Metformin:A Multicenter, Open-Label Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the change in glycated hemoglobin (HbA1c) levels of adding cofrogliptin compared to escalation of metformin dose after 24 weeks in type 2 diabetes patients who have failed to achieve adequate glycemic control despite receiving combination therapy with SGLT2i and metformin. Participants will be asked to use either cofrogliptin combined with SGLT2i and metformin or SGLT2i combined with increased dose of metformin. |
CHAO ZHENG; | 2025-03-30 |
| 57 | The Effect of Electronic Patient Decision Support System Developed for Use Patients with Type 2 Diabetes (DiaPaDeSS) on Self-Management, Patient Activation and Metabolic Parameters PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the effects of an electronic patient decision support system developed for the use of patients with type 2 diabetes (DiaPaDeSS) on self-management, patient activation, and metabolic parameters. To manage type 2 diabetes after discharge, patients must continue to perform interventions at home, such as blood glucose monitoring, blood pressure measurement, weight measurement, medication use, and foot care. To achieve this, … |
MERVE YUKSEL; | 2025-03-30 |
| 58 | A Parallel-Group Treatment, Phase 2, Double-Blind Study of Once-Weekly Subcutaneous LY3457263 Compared to Placebo in Participants With Type 2 Diabetes Mellitus on A Stable Dose of Semaglutide or Tirzepatide Who Failed to Achieve HbA1c Goal PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months. |
ELI LILLY | 2025-03-28 |
| 59 | Safety and Efficacy of The Omnipod® SmartAdjust 2.0 System Compared to The Omnipod® 5 System in Individuals With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this multi-center, randomized, cross-over study is to evaluate the safety and effectiveness of the Omnipod 5 SmartAdjust 2.0 System in individuals with type 1 diabetes. Study participants will complete about 5 in-person visits and be expected to treat their diabetes per their usual routine using the system at the lowest available target setting. Each participant will begin the study using either the Omnipod 5 SmartAdjust 2.0 System or the Omnipod 5 System for 4 weeks (Period 1) then switch to the opposite system for the next 4 weeks (Period 2). Everyone will use the Omnipod 5 SmartAdjust 2.0 System for the last 4-6 weeks (Period 3). During Period 3, participants will have a goal of administering no more than 3 meal or snack boluses per day. |
ANNE PETERS; | 2025-03-26 |
| 60 | Efficacy and Safety of Teplizumab in The Treatment of Japanese Pediatric and Adult Participants Aged 8 to 34 Years With Stage 2 Type 1 Diabetes: A Multicenter, Randomized, Open-label, Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a parallel, Phase 2, two-arm study to assess the efficacy and safety of 14-days intravenous (IV) infusion of teplizumab treatment. Teplizumab has been approved by FDA to delay the onset of Stage 3 Type 1 Diabetes (T1D) in adults and pediatric patients aged 8 years and older with Stage 2 T1D. The dose regimen of teplizumab in this study is consistent with the regimen approved by US FDA. Given prior clinical studies conducted in Western countries, this design is appropriate to assess the efficacy, safety and tolerability, pharmacokinetic, pharmacodynamic, … |
SANOFI | 2025-03-26 |
| 61 | Prospective Post-market Clinical Follow-up (PMCF) Study Aimed to Evaluate The Change in Glucometric Parameters in Adult Patients With Type 1 or Type 2 DiabETes From Europe Using The ICan O3 CGM SysTem for A 60-day Period PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a post-market, prospective, interventional, multicenter clinical trial designed to evaluate the impact of the iCan O3 Continuous Glucose Monitoring (CGM) System on glycemic control in adults with Type 1 (T1D) or Type 2 Diabetes (T2D). Coordinated by Prof. Dr. Christophe De Block at Universitair Ziekenhuis Antwerpen (UZA), Belgium, and sponsored by Changsha Sinocare Inc., the study aims to assess changes in glucometric parameters over 60 days. The primary objective is to demonstrate an improvement in Time in Range (TIR) compared to baseline, … |
SINOCARE | 2025-03-25 |
| 62 | Effects of Vitamin D3 and Yeast Beta-Glucan Supplementation on Cardiovascular Disease in Patients with Type 2 Diabetes: A Randomized Double-Blind Controlled Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, double-blind, placebo-controlled trial involving 8,000 individuals aged 40-79 with type 2 diabetes. The trial includes a 2-year intervention period followed by 3 years of follow-up. The primary objective is to investigate whether daily dietary supplementation with vitamin D3 (1600 IU) or yeast β-glucan (600 mg) reduces the risk of major cardiovascular diseases, including myocardial infarction, stroke, treated or hospitalized heart failure, and cardiovascular deaths. The secondary objectives include evaluating the effects of vitamin D3 or yeast β-glucan supplementation on all-cause mortality, microvascular disease, cognitive function, and other outcomes. |
AN PAN; | 2025-03-20 |
| 63 | The Effect of Propolis Administration on Low Density Lipoprotein and High Density Lipoprotein in Diabetic Type 2 Patients in Central Jakarta PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if propolis administration works to change the level of Low Density Lipoprotein (LDL) and High Density Lipoprotein cholesterol (HDL) in diabetic type 2 patients. The main questions it aims to answer are: – Is giving 1 drops/ 10kg/ times, … |
DRG. DWIRINI RETNO GUNARTI; | 2025-03-18 |
| 64 | Establishing A Sustainable Diabetes Care Management Program Using Continuous Glucose Monitors and Remote Patient Monitoring for Underserved Populations in Safety Net Clinics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this 52 week prospective study is to learn whether a Diabetes Care Management Program using a continuous glucose monitor (CGM) and remotely monitoring (RPM) glucose readings can help improve glucose levels and diabetes related distress in individuals with uncontrolled type 2 diabetes. The CGM and RPM are used as an adjunct to usual care. The main questions it aims to answer are: Does use of CGM \& RPM improve A1c? Does use of CGM \& RPM improve the percent of time spent with glucose levels between 70-180 mg/dl? Does the diabetes care management program improve diabetes related distress? Participants enrolled in the study will be wearing a CGM. Participants will be able to see the glucose readings from the CGM and see how their glucose level responds to food, physical activity, medications and daily life. The diabetes primary care team will be remotely monitoring the participant’s glucose data from the CGM. They will reach out to the participant to make adjustments in treatment regimen as needed. Participants will answer a Problem Areas in Diabetesquestionnaire that asks questions about diabetes related distress. |
SUSHMA REDDY; | 2025-03-18 |
| 65 | A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight (MARITIME-2) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight. |
AMGEN | 2025-03-17 |
| 66 | Commercial or Open Source Closed Loop Impact on Pregnancy (COSCLIP) Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The main questions this study aims to answer are: * What are the maternal and neonatal outcomes with AID system use in pregnancy? * What are the glycemic outcomes with AID system use in pregnancy? * What are the behavioral and emotional outcomes with AID system use in pregnancy? Researchers will compare pregnant people who use commercial AID systems and pregnant people who use open source AID systems to see if outcomes are different with these different types of systems. Participants will be asked to remotely share their AID system data with the research team; complete online surveys regarding behavioral and emotional health; and sign an authorization to release health information to allow the research team to access medical records. |
NASIM SOBHANI; | 2025-03-13 |
| 67 | A Phase II Randomised, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Overweight or Obesity With Type 2 Diabetes Who Are on A Stable Dose of GLP-1 Receptor Agonist PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase II study is a randomized, parallel group, double blinded, placebo-controlled, multicenter to evaluate the efficacy, safety, and tolerability of AZD6234 in adults with overweight or obesity and type 2 diabetes on stable GLP-1 RA therapy. |
ASTRAZENECA | 2025-03-12 |
| 68 | Culturally Grounded Diabetes Intervention With Lakota Populations in South Dakota PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this research is to evaluate a scientifically rigorous diabetes intervention, Together Overcoming Diabetes (TOD), that has been tailored to address the unique underlying risk and protective factors and social determinants of diabetes among American Indian/Alaska Native (AI/AN) populations. |
DONALD WARNE; | 2025-03-11 |
| 69 | The Association Between Cognitive Function and Diabetic Neuropathy in Individuals With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate whether individuals with different types of diabetic neuropathy (peripheral and cardiovascular autonomic neuropathy) are at an increased risk of cognitive impairment and to investigate the potential reasons for this association. The primary research question is: Is diabetic peripheral and cariovascular autonomic neuropathy in type 2 diabetes associated with cognitive decline? To address this question, the study will include individuals with and without type 2 diabetes. All participants will undergo comprehensive neuropathy assessments, neuropsychological evaluations and blood biomarker analysis. In addition, some individuals will undergo structural and functional brain MRI. |
STENO DIABETES CENTER COPENHAGEN | 2025-03-10 |
| 70 | The Effect of Oxytocin on The Alpha Cell Response to Hypoglycaemia in Patients with Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigating the effect of oxytocin on pancreatic endocrine functions by determining glucagon secretion during hypoglycemia in participants with type 1 diabetes. |
ASGER LUND; | 2025-03-10 |
| 71 | Continuous Glucose Monitoring for Outpatient Diabetes Management After Hospital Discharge PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to improve patient awareness of the utility of continuous glucose monitoring systems in blood glucose monitoring and to improve patient satisfaction regarding diabetes care, particularly in the matter of blood glucose monitoring, at the transitions of care from the inpatient setting to the ambulatory setting. |
ANGEL MORVANT; | 2025-03-09 |
| 72 | Study of Diabetes’ Risk Factors and Accelerated Aging According to Socio-economic Status in A Population from The North of France – 3-year Follow-up PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Populations in precarious situations or with low socio-economic status are at greater risk of diabetes and accelerated ageing. Depending on the population studied, the factors that may explain these health inequalities are not unequivocal and remain poorly understood. Northern France, which is particularly affected by socio-economic disparities, has one of the highest diabetes prevalence rates in mainland France. This is why the researchers wanted to study the clinical, biological, … |
CORALIE BERTHIER; | 2025-03-05 |
| 73 | Prospective Cohort Study on Endo-Exdo Secretory Function Alterations and All-round Outcomes After Pancreatic Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about post-surgery of pancreatic cancer diabetes mellitus.The main questions it aims to answer are: 1. Are the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after pancreatic cancer of different etiologies the same? 2. Are alterations in endocrine and exdocrine secretory function in patients with pancreatic surgery associated with all-round outcomes? All patients with pancreatic surgery have been given the standardized treatment for the condition. The reasearchers will summarize the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) during different surgical procedures to explore the association between alternations in endocrine and exdocrine secrectory function and all-round outcomes. |
TUO LI; | 2025-03-03 |
| 74 | Hyperglycemia Induced Hyperexcitability: A Novel Role for KATP in The Progression of Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Insulin is a hormone that is made by β-cells in the pancreas and when released into the bloodstream helps control blood sugar levels. Insulin release is regulated by electrical activity in the β-cell which is generated by the ATP-sensitive potassium (KATP) channel. While reduced KATP activity is associated with increased insulin secretion, animals lacking KATP exhibit reduced secretion. This crossover from hypersecretion to undersecretion with KATP loss mirrors insulin secretion during type 2 diabetes. Intriguingly, … |
NATHANIEL YORK; | 2025-03-03 |
| 75 | First Trimester Prediction of Gestational Diabetes Mellitus By Continuous Glucose Monitoring PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Gestational diabetes mellitus (GDM) is the most common complication of pregnancy, with an incidence rate of 10-15% \[1\]. Common risk factors for GDM are increased maternal age and weight and as a consequence of women delaying childbirth and increasing incidence of obesity, there is a corresponding increase in the rate of GDM. GDM is associated with an increased risk of maternal and perinatal short and long-term complications . These include macrosomia, shoulder dystocia, neonatal hypoglycaemia, neonatal hyperbilirubinemia, and perinatal mortality. Maternal complications include higher risks of hypertensive disorders, perineal trauma, and caesarean section. Additionally, … |
CATALINA DE PACO MATALLANA; | 2025-03-01 |
| 76 | Effectiveness, Implementation and Spillover Effects of A Culturally Adapted Diabetes Prevention Program in Spanish Primary Care Centers: A Cluster Randomized Hybrid Type II Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The ALADIM trial is a hybrid type II effectiveness-implementation cluster-randomized controlled, parallel, two arm, superiority trial. The clusters consist of 10 Primary Care Centers (PCCs) of Mallorca (Balearic Islands, Spain), which are randomly assigned to either the intervention or the control group in a 1:1 ratio. The intervention group (5 PCCs) receives training and supporting material to facilitate the implementation of the adapted DPP and effectively deliver the program over a 12-month period. The control group (5 PCCs) continues providing usual care, … |
MIQUEL BENNASAR-VENY; | 2025-03-01 |
| 77 | Studying The Presence of CFRD Complications with Thoughtful Recruitment of Multiethnic Minoritized (SPeCTRuM) Groups PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This multicenter cross-sectional study will include a racially and ethnically diverse population of adolescents and adults with CF. The overall Aim is to describe prevalence of diabetes microvascular complications and macrovascular surrogates in people with established CFRD. |
JAEB CENTER FOR HEALTH RESEARCH | 2025-03-01 |
| 78 | Knowledge, Attitude and Awareness of Diabetic Patients on Association Between Oral Health and Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetic patients will be asked to answer a group of questions about the predictors (age, type of diabetes, level of education) and about the outcomes \[knowledge and awareness of the link between diabetes and oral health, and attitude towards maintaining their oral health as diabetics. |
AYAT GAMAL-ABDELNASER; | 2025-03-01 |
| 79 | English Title of Research Project: Effects of Dapagliflozin on Inflammatory Markers, Erythropoiesis and Iron Metabolism in Patients with Type 2 Diabetes and CKD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: the effect of Dapagliflozin on erythropoiesis, iron metabolism and inflammatory markers in CKD with Type 2 DM-Compare between effect of placebo and dapagliflozin on erythropoiesis, iron metabolism and inflammation markers in CKD with Type 2 DM. |
ZEINAB KHODARY SAADY ALI; | 2025-03-01 |
| 80 | A Trial Investigating The Efficacy and Safety of LC-Z300-01 in Adults With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial is conducted in China. The aim of the trial is to investigate the efficacy and safety of an Bamboo cane polysaccharide (oral LC-Z300-01) in subjects with type 2 diabetes. |
SHANGHAI CHANGZHENG HOSPITAL | 2025-03-01 |
| 81 | Comparison of Glucophage Plus Myo-Inositol Versus Glucophage in Terms of Glycemic Control Among Patients with Gestational Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial aims to compare the efficacy of Glucophage plus Myo-Inositol versus Glucophage alone in glycemic control among patients with gestational diabetes mellitus (GDM). The study will assess whether the addition of Myo-Inositol improves glycemic control and reduces insulin requirements in GDM patients. Participants will be randomized into two groups: one receiving Myo-Inositol in combination with Glucophage and the other receiving Glucophage alone. The primary outcome will be glycemic control as assessed by fasting and postprandial glucose levels. Secondary outcomes include insulin requirement and gestational age at initiation of insulin therapy. |
HIFZA RASHEED; | 2025-03-01 |
| 82 | A Phase 2 Study to Evaluate The Efficacy, Safety, and Tolerability of VX-880 in Subjects With Type 1 Diabetes With A Kidney Transplant PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the efficacy, safety, and tolerability of VX-880 in participants with Type 1 Diabetes (TID) with a kidney transplant. |
VERTEX PHARMACEUTICALS | 2025-03-01 |
| 83 | A 52-week Randomized, Double-blind, Placebo-controlled, Multi-center Phase 2a Study Assessing Safety and Efficacy of SAR442970, A Dual Anti-TNF-α and Anti-OX40L NANOBODY® Molecule, for Preservation of Pancreatic Β-cell Function in Adults and Adolescents With Recently Diagnosed Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, placebo-controlled, parallel group, multicenter, double-blind Phase 2a, 2-arm study. The goal of this Phase 2a study is to assess safety and efficacy of SAR442970 in comparison to placebo to preserve β-cell function in participants with recently diagnosed type 1 diabetes (T1D) on insulin therapy. The study design comprises 2 parts: in Part A adult participants (18 to 35 years of age at screening) and in Part B adolescent and young adult participants (age range 12 to 21 years) will be randomized into SAR442970 and placebo groups. Approximately 84 participants will be included with randomization ratio 3:1 (active:placebo). The study includes a screening period (3 to 5 weeks), a double-blind treatment period of 52 weeks and a safety follow-up of 26 weeks. |
SANOFI | 2025-02-28 |
| 84 | Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Minoritized individuals with type 1 diabetes (T1D) have approximately 2% higher average A1c levels and twice the rate of hospitalizations, complications, and mortality as their white counterparts. However, the efficacy trials establishing the benefits of hybrid closed loop (HCL) pump therapy in T1D have been in more socially advantaged and predominantly non-Hispanic white patients. Use of this technology by individuals with T1D from underserved communities remains very low. The investigators plan to conduct a randomized effectiveness trial – with broader eligibility criteria (including markedly elevated A1c) and longer follow up than the previous HCL efficacy trials – … |
HOWARD WOLPERT; | 2025-02-27 |
| 85 | Effect of Fiber Supplementation on The Need for Medication with Gestational Diabetes: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The hypotheses to be tested are 1) Fiber supplementation will decrease the need for medication in patients with gestational diabetes, and 2) Fiber supplementation will decrease adverse maternal and neonatal outcomes in these patients. In this study, the investigators will conduct a randomized controlled trial to limit bias in evaluating these hypotheses. |
JERRI WALLER; | 2025-02-24 |
| 86 | Comparative Effectiveness on Glycemic Balance of A Non-pharmacological Treatment, Adapted Physical Activity (APA), Either Supervised By A Qualified APA Instructor or Unsupervised in Autonomy, in Individuals with Inadequately Controlled Type 2 Diabetes, Under Diet Alone or Non-insulin Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparative effectiveness on glycemic balance of a non-pharmacological treatment, Adapted Physical Activity (APA), either supervised by a qualified APA instructor or unsupervised in autonomy, in individuals with inadequately controlled Type 2 Diabetes, under diet alone or non-insulin treatment. |
CENTRE D’ETUDES ET DE RECHERCHE POUR L’INTENSIFICATION DU TRAITEMENT DU DIABÈTE | 2025-02-24 |
| 87 | The Effect Of Acupressure and Foot Exercise on Ankle Brachial Index in Individuals With Type 2 Diabetes: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was planned with a randomized controlled experimental design to examine the effects of acupressure and ankle exercises on ankle brachial index in individuals with Type 2 diabetes. |
SAADET CAN ÇIÇEK; | 2025-02-24 |
| 88 | A Phase III Clinical Study Comparing The Efficacy and Safety of Once-weekly GZR4 Versus Once-daily Insulin Degludec With or Without Non-Insulin Antidiabetic Agents in Subjects With Type 2 Diabetes Mellitus (T2DM) Treated With Basal Insulin PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to compare the efficacy, safety and patient-reported outcome of once-weekly GZR4 and once-daily Insulin Degludec with or without Non-Insulin Antidiabetic Agents in subjects with Type 2 Diabetes Mellitus (T2DM) treated with basal insulin. |
GAN & LEE PHARMACEUTICALS | 2025-02-17 |
| 89 | Enhancing Digitally Delivered Diabetes Education With Real-Time CGM: A Comparative Study in People With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current research study will add continuous glucose monitoring devices to the evidence-based text messaging diabetes education program for patients with type 2 diabetes for 6 months. Results on the effectiveness of this intervention will be compared for non-insulin using patients. |
ATHENA PHILIS-TSIMIKAS; | 2025-02-17 |
| 90 | The Young Men’s Christian Association (YMCA) Healthy Lifestyle Program for Prediabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this 26 week randomized controlled clinical trial is to learn if using a real time continuous glucose monitor (CGM) in a healthy lifestyle program for adults with prediabetes at the YMCA can improve glucose levels, … |
SUSHMA REDDY; | 2025-02-17 |
| 91 | Artificial Intelligence to Improve Cardiometabolic Risk Evaluation Using CT Scans PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To validate the ability of the FatHealth algorithm to identify individuals with pre-diabetes and with type 2 diabetes mellitus |
CARISTO DIAGNOSTICS | 2025-02-15 |
| 92 | The Effect of Motivational Interviewing Based on Health Promotion Model on Diabetes Self-management and Cyberchondria Severity in Individuals With Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: The aim of this study was to determine the effects of diabetes education given to individuals with diabetes using motivational interviewing technique based on the health promotion model on diabetes self-management and cyberchondria severity. Materials and Method: The population of the study consisted of 1000 individuals. The sample consisted of 64 individuals, 32 experimental and 32 control, who met the research criteria. The research will be conducted between 15.02.2025-15.03.2025 in Van Regional Training and Research Hospital Diabetes outpatient clinic. Data in the research; Descriptive Information Form, Diabetes Self-Management Scale (DMS), … |
GÜLŞEN ALTUNTAS ÇALIM; | 2025-02-15 |
| 93 | Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease : Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus is a non-transmissible disease whose incidence is growing worldwide . This pathology is defined by a chronic hyperglycaemia linked to a deficiency of either insulin secretion or its action or both. This increased prevalence is linked to the growing of the obese population on one hand, and to the ageing of the population, on the other hand, which is associated with an increased prevalence of metabolic diseases. The number of patients with diabetes, particularly type 2 diabetes (T2D) is regularly increasing. In France, the prevalence of diabetes is 4- … |
PIERRE JEAN SAULNIER; | 2025-02-13 |
| 94 | A Real-World Observational Study Characterizing Patients With Type 1 Diabetes Treated With Teplizumab PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the destruction of pancreatic β cells. T1D pathogenesis progresses through several stages: Stage 1 T1D includes the presence of β cell autoimmunity and thus presence of islet autoantibodies, without the presence of dysglycemia and symptoms. Stage 2 T1D includes the presence of islet autoantibodies and dysglycemia, also with no symptoms. Stage 3 T1D includes presence of islet autoantibodies, overt hyperglycemia, and symptoms; … |
SANOFI | 2025-02-11 |
| 95 | Pilot Trial of Financial Navigation and Peer Support to Improve Diabetes Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial pilot study is to test the feasibility, acceptability, and preliminary efficacy of a combined intervention strategy of 1) technology-supported financial navigation to address economic burden of disease and 2) peer support both to facilitate linkages to clinical care and community resources to address social risks and improve participants\&#39; … |
MINAL PATEL; | 2025-02-11 |
| 96 | Evaluation of A Pragmatic NT-ProBNP-based Heart Failure Screening Strategy Among Patients with Type 2 Diabetes: STRONG-DM Study (Screening and Treatment Using Risk-based ApprOach with NT-ProBNP Guidance in Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a clinical decision support tool to implement an intensive prevention strategy among patients with high risk focused on implementation of evidence-based HF preventive therapies. |
AMBARISH PANDEY; | 2025-02-10 |
| 97 | Optimization and Evaluation of The Diagnosis and Treatment System for Diabetic Retinopathy in Type 2 Diabetes Mellitus PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to integrate clinical indicators and features of fundus images, combined with metabolomics, to construct an early warning model for diabetic retinopathy (DR) in type 2 diabetes. By combining clinical indicators with metabolomics, the investigators aim to establish a precise DR typing model based on the age of diabetes onset (early-onset diabetes, … |
YUFAN WANG; | 2025-02-01 |
| 98 | A Multi-centre, Prospective, Open Label, Non-interventional, Single-armed, 52 Weeks Post-marketing Study to Investigate Safety and Clinical Parameters of Awiqli Once Weekly in Patients With Diabetes Mellitus Under Real-world Clinical Practice Setting in Japan PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to investigate the safety and effectiveness of Awiqli in participants with diabetes mellitus under real world clinical practice in Japan. Participants will get Awiqli as prescribed by the study doctor. The study will last for about 1 year. |
NOVO NORDISK | 2025-02-01 |
| 99 | Identifying The Mechanisms of Gut-brain Axis to Sweet Sensing in Patients With Type 2 Diabetes Using Neuroimaging Techniques PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes is a global challenge and the number of people affected by diabetes is expected to rise to 5.5 million by 2030, of which 90% are type 2 diabetes (T2D). Habitual high consumption of sugars is an important risk factor in the development, and progression, … |
SALLY ELDEGHAIDY; | 2025-02-01 |
| 100 | Real-world Effects of Using Intermittently Scanned Continuous Glucose Monitoring and Pharmacist-led Coaching on The Management of Type 2 Diabetes Among Adults Using Non-insulin Antihyperglycemic Agents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this prospective study is to evaluate diabetes outcomes after initiating second generation intermittently scanned continuous glucose monitoring (isCGM) plus one pharmacist consultation session compared with capillary blood glucose (CBG) monitoring among insulin-naïve adults with type 2 diabetes (T2D) in a specialist endocrinology clinical setting in Canada. Primary Outcome – To evaluate change in HbA1c at 3-6 months follow-up after initiating isCGM plus one pharmacist consultation (isCGM cohort) compared with CBG monitoring (CBG cohort) among insulin-naïve adults with T2D. Secondary Outcomes – … |
LMC DIABETES & ENDOCRINOLOGY | 2025-02-01 |
| 101 | The Effect of Hedia Diabetes Assistant on TiMe-in-range in People with Type 1 Diabetes and Sub-Optimal Glycemic Control in France – A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled study is to assess the clinical performance and safety of Hedia Diabetes Assistant in adults with type 1 diabetes and suboptimal glycemic control in France. The main question to answer is: – … |
HEDIA APS | 2025-02-01 |
| 102 | Transforming Diabetes Care: Pharmacist-Led Education and Its Impact on Patient Knowledge, Self-Management, and Health Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This interventional study is to evaluate the impact of pharmacist-led education on diabetic patients’ knowledge, self-management, and overall health outcomes. Participants in this study will attend pharmacist-led educational sessions designed to improve their understanding of diabetes and self-care practices. Researchers will assess changes in patients’ knowledge, self-management behaviors, and clinical health markers before and after the intervention. The study will compare pre- and post-intervention results to determine the effectiveness of pharmacist-led education in transforming diabetes care. |
SARA YAHYA; | 2025-02-01 |
| 103 | Polyphenol Metabotypes in People with Diabetes Type 2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This cross-sectional study seeks to characterize the overall polyphenol metabotype in patients with T2DM in comparison to age-matched individuals without diabetes. Additionally, the study aims to identify factors that influence the polyphenol metabotype (transit time and gut microbial capacity to degrade polyphenols in particular). |
BRUNO LAPAUW; | 2025-01-31 |
| 104 | A Phase 2 Double-blind Randomised Controlled Trial Studying The Effect of Sotagliflozin Versus Placebo in Individuals With Heart Failure and Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: People with type 1 diabetes sometimes develop heart failure which can cause symptoms like breathlessness, tiredness or ankle swelling, reduced quality of life and lead to being admitted to hospital or suffering potential fatal consequences. This trial is investigating if a tablet called sotagliflozin, can improve quality of life in people with type 1 diabetes and heart failure. In addition, this trial will also assess the safety and tolerability of sotagliflozin in this population. In previous trials that included people with type 2 diabetes and heart failure sotagliflozin was shown to improve patients’ symptoms of heart failure, … |
IFY MORDI; | 2025-01-28 |
| 105 | The Impact of Social Determinates of Health on Risk for Diabetes in The Hispanic Community: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is twofold: to see the impact of your environmental stress on daily glucose changes and to create an intervention using CGM to potentially decrease risk for diabetes. The aim of this study to develop an intervention to prevent diabetes in the Hispanic community and inform policies about social determinants of health. |
UNIVERSITY OF TEXAS AT AUSTIN | 2025-01-28 |
| 106 | A Study Investigating The Pharmacokinetic and Pharmacodynamic Properties and Safety and Tolerability of NNC0471-0119 H When Administered As Bolus in A Continuous Subcutaneous Insulin Infusion Regimen in Participants With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is looking at the effect and safety of a new fast-acting insulin (NNC0471 0119) to people with type 1 diabetes when given by an insulin pump. The study tests how fast insulin NNC0471-0119 enters your bloodstream, how long it stays there and how much it lowers blood sugar. The new insulin NNC0471-0119 will be compared to insulin aspart. The participants will get each study medicine administered at separate clinic visits. The study will last for about 1-3 months. |
NOVO NORDISK | 2025-01-28 |
| 107 | Retrospective Review of Preoperative Optimization of Diabetic Patients PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetic patients, as part of preoperative evaluation, should have glycated hemoglobin (HbA1C) measured. HbA1C provides information on longterm glucose control. There is a suggestion in the literature that elevated A1C levels predict a higher rate of postoperative adverse events, including infections, myocardial infarction, and mortality. It is unclear whether chronic glycemia, as reflected in raised HbA1C level, is the risk factor for adverse perioperative events or whether it is a surrogate measure for poor perioperative glucose management. Conversely, in a retrospective analysis of 431,480 surgeries perioperative glucose was predictive of increased 30-day mortality, … |
UNIVERSITY OF ALBERTA | 2025-01-22 |
| 108 | Impact of SMS Reminder on Weight Loss, As Part of A Hygieno-dietary Health Pathway in Patients with Prediabetes: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventionnal study is to demonstrate that sending SMS messages with advice on physical activity or nutrition, in addition to a program of hygienic-dietary management, significantly increases weight loss in subjects with prediabetes in La Réunion. Indeed, type 2 diabetes is a priority health problem on Reunion Island: 10% of the population are treated for type 2 diabetes, twice as many as in France. International studies have demonstrated the value of modifying dietary and physical activity habits to reduce the risk of transition to diabetes in patients with prediabetes Against this backdrop, … |
LERUSTE SEBASTIEN; | 2025-01-22 |
| 109 | Michigan Men’s Diabetes Project 3 (MenD 3): Mind and Motion PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Michigan Men’s Diabetes Project III: Mind \& Motion is an 7-month pilot randomized clinical trial. The investigators are looking to recruit 80 Black men with type 2 diabetes (T2D) (need to have diagnosis for at least one year) that are over the age of 18. Participants also must be under the care of a physician for their diabetes, self report an Hemoglobin A1c (A1C) of 7.0% or more in the last year, be willing to participate in study events (weekly physical activity, exercise and Cognitive Behavioral Therapy (CBT) sessions, group discussion sessions, and in-person health assessments), … |
JACLYNN HAWKINS; | 2025-01-13 |
| 110 | Capability Assessment for Diet and Activity Model Extended to Include Screening and Knowledge in Diabetic Adults PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the capabilities related to diet, physical activity, screening, and knowledge among diabetic adults with or without a history of hospital admissions in Central Florida. The hypothesis is that enhancing these capabilities, based on the Capability Approach framework, can significantly reduce hospital readmissions and improve diabetes management outcomes. |
UNIVERSITY OF CENTRAL FLORIDA | 2025-01-10 |
| 111 | Effects of D-Chiro-Inositol Combined with Metformin on Insulin Resistance in People with Overweight or Obesity and Type 2 Diabetes Mellitus: A Placebo-controlled Randomized Double-Blind Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the efficacy of D-Chiro-Inositol (DCI) as an add-on therapy to metformin in improving insulin resistance, measured by the HOMA index, in people with overweight or obesity and type 2 diabetes mellitus (T2DM). Secondary outcomes include glycemic variability, indirect calorimetry, respiratory quotient, and other metabolic parameters. |
SILVIA MANFRINI; | 2025-01-10 |
| 112 | A Phase 3, Open-Label, Multicenter, Single-Arm Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Efficacy of Dulaglutide 3.0 Mg and 4.5 Mg in Pediatric Participants 10 to Less Than 18 Years of Age With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate additional dosing options for dulaglutide in pediatric participants with Type 2 Diabetes. Participation in this study will last about 8 months. |
ELI LILLY | 2025-01-10 |
| 113 | Testing and Refinement of PACTAID App in Patients with Type 1 Diabetes to Help Manage Exercise While on Automated Insulin Delivery System Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to test and refine the PACTAID smart phone application in adults with type 1 diabetes mellitus to help manage exercise while on automated insulin delivery systems with the goal of improving glycemic control during and after exercise as well as improving multiple other cardiovascular risk factors. |
YOGISH C. KUDVA; | 2025-01-10 |
| 114 | Effectiveness of Individualized Automatic Target Coaching Message Based on The Metrics of Continuous Glucose Monitoring and Depressive Symptom in Patients With Insulin-treated Type 2 Diabetes: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 12-week, single-center, randomized, prospective, confirmatory study of effectiveness of the individualized automatic coaching messages for glycemic management based on continuous glucose monitoring and depressive symptom in insulin-treated patients with type 2 diabetes. |
GYURI KIM; | 2025-01-09 |
| 115 | A Randomized, Open-label, Treat-to-target, Parallel-controlled, Phase II Clinical Study to Evaluate The Efficacy and Safety of SHR-3167 and Insulin Glargine in Patients With Type 2 Diabetes Mellitus With Metformin Alone or in Combination With SGLT2 Inhibitors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and safety of SHR-3167 compared with insulin glargine after treatment in insulin naïve subjects with type 2 diabetes treated with metformin alone or in combination with SGLT2 subjects. |
YUN LIU; | 2025-01-08 |
| 116 | Multicentre Phase IV Single Arm Clinical Trial to Evaluate The Safety and Efficacy of A Fixed Ratio Combination of Insulin Glargine and Lixisenatide in Adult Patients With Type 2 Diabetes Who Are Sub Optimally Controlled on Oral Anti-hyperglycemic Drugs And/or Basal Insulin/GLP-1 RA PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an intervention, phase IV, single-arm study to assess the safety and efficacy of iGlarLixi in adult patients with Type 2 diabetes. |
SANOFI | 2025-01-06 |
| 117 | The Separate and Combined Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Subjects with and Without Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The hormone glucose-dependent insulinotropic polypeptide (GIP) is naturally produced in the intestine during a meal and stimulates insulin secretion from the pancreas. Insulin ensures that nutrients from the meal are transported from the blood into the cells, allowing the body to use it as energy. If blood sugar levels drop too much, the body naturally releases another hormone: glucagon. Glucagon is responsible for the breakdown of nutrients inside the cells, thus causing blood sugar levels to rise again. This occurs, for example, when a person is fasting or in an energy deficit. Unfortunately, … |
ASGER LUND; | 2025-01-01 |
| 118 | A Randomized Controlled Study on The Effects of Xuezhikang and Atorvastatin on Blood Glucose and Lipid Levels in Patients With Dyslipidemia and Prediabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares the impact of Xuezhikang and atorvastatin on glucose metabolism to explore the incidence of prediabetes patients developing diabetes after 24 weeks of Xuezhikang use, and by investigating the effect of Xuezhikang on blood glucose fluctuations, discusses the possible mechanisms by which Xuezhikang affects glucose metabolism. |
LIXIA JIN; | 2024-12-31 |
| 119 | A Phase 1/2a Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ARO-INHBE in Adult Volunteers With Obesity With and Without Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1/2a double-blind dose-escalating study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single and multiple doses of ARO-INHBE in adult participants with obesity (Part 1), and the safety, tolerability and PD of multiple doses of ARO-INHBE in adult participants with obesity with and without type 2 diabetes mellitus receiving tirzepatide (Part 2). |
ARROWHEAD PHARMACEUTICALS | 2024-12-21 |
| 120 | A Multicenter, Randomized, Controlled Clinical Study of 3mg Once Every Two Weeks Administration of Efsubaglutide Alfa Injection in Type 2 Diabetes Patients With Poor Glycemic Control After Diet and Exercise Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to evaluate the impact and efficacy of Efsubaglutide Alfa injection 3mg QoW on the treatment of type 2 diabetes patients with poor glycemic control after dietary and exercise intervention. Primary objective: To evaluate the effect and role of continuous treatment with 3mg of Efsubaglutide Alfa QoW and 1mg of Efsubaglutide Alfa QW for 12 weeks on HbA1c in T2DM patients with poor glycemic control after dietary and exercise intervention. Secondary objectives: 1. To evaluate the effect of continuous treatment with 3mg of Efsubaglutide Alfa QoW for 12 weeks on glucose variability (change in time in range (TIR) relative to baseline) in T2DM patients with poor glycemic control after dietary and exercise intervention. 2. To evaluate the effect of continuous treatment with 3mg of Efsubaglutide Alfa QoW for 12 weeks on drug exposure (relative to 1mg QW) in T2DM patients with poor glycemic control after dietary and exercise intervention. 3. To evaluate the effect of continuous treatment with 3mg of Efsubaglutide Alfa QoW for 12 weeks on fasting plasma glucose (FPG) in T2DM patients with poor glycemic control after dietary and exercise intervention. |
SHANGHAI YINNUO PHARMACEUTICAL TECHNOLOGY | 2024-12-18 |
| 121 | Comparison of Efficacy of Once Weekly Dose of Trelagliptin Versus Once Daily Dose of Vildagliptin on The Levels of HbA1c in Type-2 Diabetes Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial evaluated the efficacy of once-weekly trelagliptin compared to once-daily vildagliptin in reducing HbA1c levels in patients with type 2 diabetes mellitus (T2DM). A total of 102 participants, aged 30-60 years with HbA1c levels between 7.5% and 9.5%, were enrolled and randomly assigned to either the trelagliptin or vildagliptin group. The primary outcome measured was the percentage of participants achieving an HbA1c level of less than 7% after three months of treatment. Secondary outcomes included the mean reduction in HbA1c levels from baseline. The study aimed to determine whether trelagliptin, with its once-weekly dosing regimen, … |
MUHAMMAD IRFAN JAMIL; | 2024-12-15 |
| 122 | Early Feasibility Study to Evaluate An Intravascular Blood Continuous Glucose Sensor in Adults with Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this early first in man clinical trial is to evaluate the safety of an implantable continuous blood glucose monitoring system in participants with Diabetes Mellitus. Safety will be assessed by looking at the absence of procedure or device related adverse events. Additionally, … |
GLUCOTRACK | 2024-12-13 |
| 123 | Use of Clinical-trials and Simulation Models to Estimate Cost-effectiveness of Non-steroidal Mineralocorticoid Antagonists, RASi and SGLT2i As Triple Therapy with Type 2 Diabetes and Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate triple therapy with nsMRA, RASi and SGLT2i on albuminuria in individuals with T2D and CKD |
ELAINE CHOW; | 2024-12-12 |
| 124 | The Balanced and Empowered Eating (BEET) in Diabetes Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Disordered eating behaviors (DEBs, e.g., binge eating or restrictive eating) can significantly impact type 2 diabetes (T2D) self-management and engagement in treatment for diabetes. Managing DEBs is a treatment component in diabetes self-management; however, it is not often the primary focus, and trained behavioral health providers are inconsistently involved in comprehensive diabetes management. This study plans to pilot two behavior change programs for disordered eating in T2D and gather information on factors that predict successful adoption and implementation in real-world clinical settings. |
PHOUTDAVONE PHIMPHASONE-BRADY; | 2024-12-06 |
| 125 | Evaluating The Practicalities & Potential Benefits of Using Remote C-peptide Testing in Clinical Practice to Confirm Established Type 1 Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research is to assess the practicalities and potential benefits of collecting home finger prick samples from all patients within a hospital type 1 diabetes service to test how much insulin each patient is producing. To do this we will send detailed study information, sample collection kits and reply-paid return packs to 1500 randomly selected patients, treated as type 1 diabetes, … |
NICHOLAS THOMAS; | 2024-12-03 |
| 126 | A Randomized, Double-blind, Placebo-Controlled Trial Comparing The Efficacy and Safety of BGM0504 Versus Placebo in Patients with Type 2 Diabetes, Inadequately Controlled with Diet and Exercise Alone PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled phase III clinical study to evaluate the efficacy and safety of BGM0504 in patients with type 2 diabetes (T2D) with poor glycemic control only through diet and exercise. The main purpose is to evaluate the clinical efficacy of BGM0504 injection monotherapy for 32 weeks compared with placebo in Chinese patients with type 2 diabetes with poor glycemic control only through diet and exercise, and to evaluate the clinical efficacy and safety of BGM0504 injection for 52 weeks of administration. |
BRIGHTGENE BIO MEDICAL TECHNOLOGY | 2024-12-02 |
| 127 | DM-BOOST Para Latinx: A Diabetes Mellitus Program Using Behavioral Economics to Optimize Outreach and Self-management Support with Technology for Latinx Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The specific aims of this project are to culturally adapt the DM-BOOST intervention for Latinx patients, usability test ‘DM-BOOST para Latinx’ to optimize cultural appropriateness and patient engagement and conduct a feasibility evaluation of DM-BOOST para Latinx. These aims will be accomplished via a community-based participatory research approach in collaboration with clinical, community and patient partners. This project will inform subsequent proposals to evaluate implementation of DM-BOOST in the UMass Memorial Health Care system. |
DANIEL AMANTE; | 2024-12-01 |
| 128 | A Phase 3, Randomized, Open-Label Trial Comparing Efficacy and Safety of BGM0504 Versus Semaglutide Once Weekly As Add-on Therapy to Metformin And/or Sulfonylureas in Patients with Type 2 Diabetes PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial is conducted in China. The aim of the trial is to evaluate the efficacy and safety of BGM0504 versus semaglutide as add-on to metformin and/or sulfonylureas in patients with type 2 diabetes |
BRIGHTGENE BIO MEDICAL TECHNOLOGY | 2024-11-29 |
| 129 | Technology-Enabled Collaborative Care for Young Adults with Type-1 Diabetes and Diabetes Distress (TECCT1D3): Feasibility Trial of A Co-designed Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to evaluate the acceptability and feasibility of a co-designed, Technology-Enabled Collaborative Care for Young Adults with Type-1 Diabetes and Diabetes Distress (TECC-T1D3) program. Through this program, the investigators aim to deliver a collaborative care intervention, featuring a health coach and a virtual care team, designed to help participants manage mental health and overall wellbeing. |
PETER SELBY; | 2024-11-27 |
| 130 | Jockey Club Precision Prevention Programme on Young Onset Diabetes PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a community-based implementation program consisting of multiple components delivered by a multidisciplinary team to detect and prevent young onset diabetes with precision and value using biogenetic markers, digital tools, integrated care through public private partnership. Adults aged between 18 and 44 (inclusive) without known diabetes and with at least one risk factor for diabetes will undergo a saliva DNA and capillary blood test and complete a questionnaire. Depending on their risk levels, … |
JULIANA CN CHAN; | 2024-11-23 |
| 131 | Beta-Cell – Liver Interactions in Situations of Modified Beta-Cell Function: From Mice to Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will measure blood levels of 1,5-anhydroglucitol in obese children with or without type 2 diabetes and correlate them with parameters related to functional beta-cell mass and glucose metabolism. The values will be compared to those obtained in healthy volunteers. The aim of the study is to test the validity of 1,5-anhydroglucitol as a novel biomarker of beta-cell mass and function in children with obesity with or without type 2 diabetes. |
PHILIPPE KLEE; | 2024-11-22 |
| 132 | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Phase 2 Study to Evaluate The Efficacy, Safety, and Tolerability of Once-Weekly CT-388 Administered Subcutaneously for 48 Weeks to Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of CT-388 at low, middle, and high doses in participants who are overweight or obese with Type 2 diabetes mellitus (T2DM). |
CARMOT THERAPEUTICS | 2024-11-21 |
| 133 | The Effect Of Model-Based Dıgıtal Game On Metabolıc Control, Self-Effıcıency And Qualıty Of Lıfe In Chıldren Wıth Type 1 Dıabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was planned to determine the effect of model-based digital game on metabolic control, self-efficacy and quality of life in children with T1DM. |
BEDRIYE AK; | 2024-11-20 |
| 134 | Survey on The Current Status of Islet Alpha Cell Function in Patients with Type 2 Diabetes and Interventional Study of GLP-1RA: A Multicenter, Prospective Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: By detecting the fasting and postprandial 120-minute glucose, insulin (Insulin, INS), C-peptide (C-peptide, Cp), glucagon (GCG) levels in newly diagnosed type 2 diabetes patients, or the 0-minute, 30-minute, 120-minute glucose, INS, Cp, GCG levels during the Oral Glucose Tolerance Test (OGTT), and examining the glucose, INS, Cp, GCG levels during hypoglycemia, the current status of islet alpha cell function in diabetic patients is observed. Type 2 diabetes patients willing to participate are treated with GLP-1RA for 3 months, and then retested for fasting and postprandial 120-minute glucose, INS, Cp, GCG, or the 0-minute, 30-minute, 120-minute glucose, INS, Cp, … |
NANJING FIRST HOSPITAL NANJING MEDICAL UNIVERSITY | 2024-11-07 |
| 135 | A Study to Evaluate The Efficacy, Safety & Tolerability of Maridebart Cafraglutide in Adults With T2DM PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the dose-response relationship of maridebart cafraglutide on glucose control compared with placebo. |
AMGEN | 2024-11-07 |
| 136 | EkiYou-Study-2 : Multicenter Randomised Controlled Trial of The EkiYou Application for Insulin Bolus Calculation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: EkiYou-Study-2 is an interventional multicenter randomised controlled clinical investigation according to EU 2017/745. It is conducted in 154 adults with diabetes and treated by multiple daily insulin injections that will be followed for 6 months. After a randomization, participants will receive for 6 months EkiYou V2 Digital Therapy that will help them to estimate their daily bolus and basal insulin doses. This device weekly adjusts insulin parameters including : basal insulin dose, insulin to carb ratios and correction factor. The control group will stay with their standard care, and after the first three months of control period, … |
DIAPPYMED | 2024-11-05 |
| 137 | Auto-antibody Dosage from Blood Spots for Diagnosis of Type 1 Diabetes and Celiace Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Early diagnosis of type 1 diabetes and celiac disease is very useful, allows early therapy and prevents deaths from the onset of diabetic ketoacidosis. This is a pilot study on screening of autoantibodies of type 1 diabetes and celiac disease in tuscany patients. The study aims to evaluate the concordance between the screening results obtained using two different matrix (blood drop spots on card and serum) in the search for autoantibodies for celiac disease and for type 1 diabetes. Moreover, … |
MEYER CHILDREN’S HOSPITAL IRCCS | 2024-11-04 |
| 138 | Effect of Flaxseed Consumption As A Treatment for Adults With Type 2 Diabetes Mellitus in Oaxaca De Juárez, Oaxaca PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 2 Diabetes Mellitus represents one of the most important health emergencies of this century Although it is known that insulin resistance is reversible and that type 2 diabetes mellitus is controllable with a change towards a healthy lifestyle, the population ignores these recommendations and continues with their unhealthy habits. Thus, the number of patients continues to grow exponentially, … |
SABINA LÓPEZ TOLEDO; | 2024-11-01 |
| 139 | Effect of Hypoglycemia Prevention and Awareness Program (HypoPAP) on Patient Outcomes: Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this project is to examine the effects of the Hypoglycemia Prevention and Awareness Program (HypoPAP) on patient outcomes, including metabolic, psychological, social, and economic parameters, in individuals with type 2 diabetes and impaired hypoglycemia awareness. Through the interventions provided to participants, the study aims to achieve the following improvements: – Physiological parameters: Enhanced glycemic control, reduced hypoglycemia frequency, improved hypoglycemia awareness, and optimized HbA1c levels. – Psychological parameters: Reduced fear of hypoglycemia, increased hypoglycemic confidence, and improved attitudes toward hypoglycemia management. – Social parameters: Decreased social withdrawal due to fear of hypoglycemia, … |
MERVE DERVIAYOAYLU; | 2024-11-01 |
| 140 | Safety Evaluation of The MiniMed™ 780G System Used in Combination with The DS5 CGM in Children 2-6 Years of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety of the MiniMed 780G insulin pump used in combination with the DS5 CGM in type 1 pediatric subjects (2-6 years of age) in a home setting. |
MEDTRONIC DIABETES | 2024-10-29 |
| 141 | Designing Team Clinic for Youth with Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about if shared medical appointment is an acceptable way to deliver care to youth with type 2 diabetes. The main question\[s\] it aims to answer are: * Design four group activities centered around nutrition therapy, peer interactions, exercise and stress management. * Design the clinical workflow for implementation phase. Participants will attend quarterly clinic appointments and group activities and take surveys. Researchers will compare this intervention to standard of care. |
LILY CHAO; | 2024-10-29 |
| 142 | The Effect of Patient Education on Foot Care Behaviour and Diabetic Foot Self-Efficacy in Individuals With Type II Diabetes: A Randomised Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effect of foot care training given according to Interpersonal Relationship Theory on foot care behaviour and diabetic foot self-efficacy. |
HILAL KAHRAMAN; | 2024-10-26 |
| 143 | Strengths-Based Multi-Level Behavioral Intervention to Promote Resilience and Self-Management in Youth With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The EMPoWER Study randomized clinical trial is a strengths-based behavioral intervention delivered to youth with type 1 diabetes (age 10 to 13) and their parents. The purpose of the intervention is to improve glycemic, behavioral, and psychosocial outcomes in youth with diabetes using a multiple systems approach that engages youth, their parents, and diabetes care providers to identify and build youths’ diabetes strengths. The primary aim of this study is to assess the intervention impact on glycemic control, adherence, … |
MARISA HILLIARD; | 2024-10-22 |
| 144 | Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics (DREAM-ON) – An Observational Cohort Study from The Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The DREAM-ON study will investigate whether continuous glucose monitoring (CGM) is useful to predict risk for developing diabetes mellitus (DM) and pre-diabetes mellitus (PDM), the need for insulin therapy among those who develop DM, and to determine whether CGM can provide insight into the pathophysiology and DM subtype among participants who have experienced an episode of acute pancreatitis (AP). Thus, the results of the DREAM-ON study could inform future clinical practice guidelines for the management AP as well as potentially extending the licensing authorization for CGM to include use in patients with pancreatogenic (Type 3c) DM. |
VERNON MICHAEL CHINCHILLI; | 2024-10-16 |
| 145 | The Impact of Motivational Interviewing and Social Media-Based Patient Monitoring on Metabolic Control and Self-Efficacy in Adolescents With Type 1 Diabetes: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study aims to determine the effects of motivational interviewing and social media-based patient monitoring on metabolic control and self-efficacy in adolescents with Type 1 diabetes. Additionally, the study will assess the adolescents' attitudes toward their disease, quality of life, … |
BÜŞRA KÜTÜK; | 2024-10-15 |
| 146 | Relationship Between Motor Imagery Ability, Body Awareness and Cognitive Functions in Individuals With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the relationship between motor imagery skills, body awareness and cognitive functions in individuals with Type 2 Diabetes mellitus. |
ISMAIL OKUR; | 2024-10-14 |
| 147 | Efficacy of Lactobacillus Paracasei LC19 on Newly Diagnosed Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, placebo-controlled clinical trial. The objective of this trial is to determine whether Lactobacillus paracasei LC19 supplementation has a positive effect on glucose lowering in patients with type 2 diabetes (T2D). |
GUANG WANG; | 2024-10-12 |
| 148 | A Phase 4, Multicenter, Multi-Country, Open-Label, Single-Arm Study to Investigate The Effectiveness and Safety of Tirzepatide Once Weekly in Adult Participants With Type 2 Diabetes During Ramadan PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of the study is to investigate whether tirzepatide can be effectively started before Ramadan and used per label in participants with Type 2 Diabetes during the fasting month. |
ELI LILLY | 2024-10-11 |
| 149 | A Single Dose Study to Evaluate The Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate how much of LY3209590 gets into the blood stream after a single dose and how long it takes the body to remove it in pediatric participants with Type 2 Diabetes Mellitus (T2DM). The study will last for approximately 100 days. |
JAMES SWAIN; | 2024-10-10 |
| 150 | Pilot RCT Evaluating Clinical Outcomes of Using Undermyfork Mobile App With Dexcom G7 in A Real-World Community Ambulatory Health Setting PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine if adding using a mobile diabetes-related health application with CGM device yields significant benefits, contributing to our understanding of the potential advantages and informing future diabetes care practices. The rationale for testing CGM with Undermyfork in individuals with T2D stems from the potential benefits of real-time glucose monitoring and personalized dietary tracking in improving glycemic control and reducing diabetes-related complications. Unlike standard care, which often involves periodic fingerstick glucose testing and limited dietary guidance, the proposed intervention offers continuous monitoring and tailored dietary insights, thus potentially improving overall diabetes management outcomes. The proposed intervention, therefore, … |
ATHENA PHILIS-TSIMIKAS; | 2024-10-09 |
| 151 | A Phase IIb, Randomized, Double-blind, Placebo-controlled and Open-label Active Comparator Study to Evaluate The Efficacy, Safety, and Tolerability of AZD5004 in Adults With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase IIb, randomised, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy, safety and tolerability of AZD5004 in adults with type 2 diabetes mellitus, compared to placebo and active comparator. |
ASTRAZENECA | 2024-10-08 |
| 152 | Prospective Cohort Study on Endocrine and Exocrine Secretory Function Alterations After Moderately Severe and Severe Acute Pancreatitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about post-acute pancreatitis diabetes mellitus (PPDM-A). The main questions it aims to answer are: 1. Are the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after acute pancreatitis of different etiologies the same? 2. Are alterations in endocrine and exocrine secretory function in patients with acute pancreatitis associated with all-round outcomes? All patients with acute pancreatitis have been given the standardized treatment for the condition. Investigators will compare the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after acute pancreatitis of different etiologies in patients with moderately severe (MSAP) and severe acute pancreatitis (SAP) to explore the association between alterations in endocrine and exocrine secretory function and all-round outcomes. |
TUO LI; | 2024-10-08 |
| 153 | DISCOVERY of Risk Factors for Type 2 Diabetes in Youth PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes. |
BARBARA BRAFFETT; | 2024-10-01 |
| 154 | Relationship Between Hemodynamic Changes and Cardiopulmonary Fitness in Type 2 Diabetes Mellitus Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus being metabolic disorder, chronic in nature, is characterized by high levels of glucose in our blood, which often lead to organ dysfunction. Approximately 10.5 % of adult (20-79 years) have diabetes according to international Diabetes federation. Cardiorespiratory fitness (CRF) is the capability of our cardiopulmonary system to make oxygen available to our skeletal muscles during physical activities for prolonged time, … |
SEYYADA TAHNIAT ALI; | 2024-10-01 |
| 155 | Evaluation of Correlations Between Volatile Organic Compounds (VOCs) Spectra Measured With GC-IMS and MOx-sensors and Venous Blood Glucose in Subjects With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate correlations between VOCs in the breath and venous blood glucose values in various glycaemic states in people living with Type 2 Diabetes. VOCs are measured with a gold-standard GC-IMS device and a prototype of a novel breath analyzer. Participants will be exposed to different blood glucose levels at different rates of change by administering glucose solution and insulin and by a meal challenge. |
MARKUS LAIMER; | 2024-10-01 |
| 156 | Early Investigation of Glucose Monitoring After Gestational Diabetes (ENGAGED): Utility and Acceptability of Continuous Glucose Monitoring in The Early Postpartum Period After Gestational Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One third of women with gestational diabetes (GDM), diabetes diagnosed during pregnancy, have abnormal glucose levels within 3 years after pregnancy, but follow up is low. Continuous glucose monitors (CGM), a small sensor inserted under the skin, … |
RACHEL D’AMICO; | 2024-10-01 |
| 157 | SMARTCLOTH. Design, Implementation and Study of The Effectiveness and Usability of A Digital Tablecloth for Self-management of Diet in Diabetic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this clinical trial is to know the usability and efficacy of SMARTCLOTH for better control and adherence to the dietary patterns recommended to patients with diabetes, both the portion diet system (more common for cases of Diabetes Mellitus type 1 -DM1-), and the plate method (more recommended in cases of Diabetes Mellitus type 2-DM2-). The main questions are: – Does the use of SMARTCLOTH improve glycemic control in patients with diabetes mellitus? – … |
MAIMÓNIDES BIOMEDICAL RESEARCH INSTITUTE OF CÓRDOBA | 2024-10-01 |
| 158 | SEMA-CardioDiab HUNGARY: A Multicentre, Prospective, Non-interventional Study to Evaluate Glycemic Control and Weight Changes in Patients With Type 2 Diabetes Initiating Treatment With Oral Semaglutide By Cardiologists or Diabetologists As Part of Local Clinical Practice in Hungary PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Participant will get oral semaglutde as prescribed by the study doctor. The study will last for about 26 ± 4 weeks (5 to 7 months). Participant will be asked to complete a questionnaire about how they take oral semaglutide tablets during normal scheduled visit with doctor. Participant will also be asked questions about health and their diabetes treatment and lab tests as part of normal doctor’s appointment. |
NOVO NORDISK | 2024-09-30 |
| 159 | An Open, Single-centre, Non-interventional Study of The CE-marked Medical Device GlucoTab, According to Intended Use Without Additional Invasive and Stressful Measures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: GlucoTab is a stand-alone software system to support healthcare professionals in the care of patients with diabetes mellitus or newly diagnosed hyperglycaemia who are treated with insulin and/or other glucose-lowering drugs or of patients only requiring glucose monitoring. It provides a therapy algorithm for subcutaneous basal insulin therapy of patients with type 2 diabetes, which will be used in this study. |
MEDICAL UNIVERSITY OF GRAZ | 2024-09-30 |
| 160 | An Observational, Long-term Safety Study of TZIELD® (Teplizumab-mzwv) in Patients With Stage 2 Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stage 2 Type 1 Diabates (T1D) is an early stage of T1D characterized by dysglycemia but not yet leading to clinical symptoms. Progression of the disease to Stage 3 (clinical T1D), leads to overt hyperglycemia requiring eventually exogenous insulin. TZIELD® (teplizumab-mzwv) has been approved to delay onset of stage 3 T1D, … |
SANOFI | 2024-09-27 |
| 161 | A Phase 3, Randomized, Double-blinded Study to Evaluate The Efficacy and Safety of HRS-7535 Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise (OUTSTAND-1) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this trial is to evaluate the efficacy and safety of HRS-7535 compared with placebo in subjects with type 2 diabetes mellitus with inadequate glycemic control with diet and exercise |
SHANDONG SUNCADIA MEDICINE | 2024-09-25 |
| 162 | A Randomized Trial of The Insulin-only Bionic Pancreas in Cystic Fibrosis Related Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This multi-center randomized controlled trial (RCT) will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas System (BP) versus a control group using their usual care insulin delivery method and continuous glucose monitoring (CGM) during a 13-week study period in individuals ≥14 years old with cystic fibrosis-related diabetes (CFRD). After 13 weeks, participants will continue in a 13-week Extension Phase in which the BP group will continue to use the BP system and the Usual Care group will initiate use of the BP system. |
CHRISTINE L CHAN; | 2024-09-24 |
| 163 | Evaluation of Validity and Reliability of The Turkish Version of The Diabetes Education Questionnaire (DATE-Q) in Patients with Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Diabetes Education Questionnaire (DATE-Q) is a questionnaire that includes comprehensive care components of diabetes management and specifically questions the effect of exercise on blood glucose levels and the knowledge of the correct exercise intensity in patients with diabetes. It can be easily and rapidly applied. The aim of this study is to evaluate the translation into Turkish, validity and reliability of the DATE-Q, which questions the knowledge of diabetic patients about their disease. |
BUKET AKINCI; | 2024-09-23 |
| 164 | A Multi-center, Cross-sectional Study to Investigate Immunological, Clinical, and Microbiological Biomarkers in Well-characterized Populations With or Without Periodontitis And/or Type 2 Diabetes Mellitus in Male and Female Participants Aged 30 -70 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn about the interactions of markers of type 2 diabetes (T2DM) and periodontitis (PD). Study VPE00001 is a multi-center cross-sectional study. Participants will be categorized based on point-of-care hemoglobin A1c (HbA1c) and periodontal disease (PD) staging into 9 subgroups. The key objectives of the study are: – To evaluate immune signatures in well-characterized populations with or without PD and/or T2DM – To evaluate baseline clinical biomarkers of T2DM and PD in well-characterized populations – To evaluate the influence of clinical, immunological, and microbiological biomarkers on the bidirectional relationship between T2DM and PD |
SANOFI PASTEUR A SANOFI COMPANY | 2024-09-20 |
| 165 | A Phase 2, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With LY3841136 and Tirzepatide, Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate the safety and efficacy of LY3841136 for chronic weight management alone or in combination with Tirzepatide across a wide dose range in participants with Type 2 Diabetes. Participation in the study will last about 64 weeks. |
YESSICA SACHDEVA; | 2024-09-20 |
| 166 | Association of Physical Activity Level and Sleep Quality with Oxidative Stress and Exercise-related Biomarker Levels in Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, we investigated the effects of physical activity level and sleep quality level on total antioxidant level (TAS), total oxidant level (TOS), Malondialdehyde (MDA) and Superoxide Dismutase (SOD) which are markers of oxidative stress, irisin, fibronectin type III-protein 5 (FNDC5). |
EMINE CIHAN; | 2024-09-20 |
| 167 | A Randomized, Single-centre, Double-blind, Placebo-controlled Proof-of-concept Parallel Group Clinical Trial to Investigate The Efficacy, Safety and Tolerability of Weekly Subcutaneous Dosing of CK-0045 in Participants with Overweight/obesity and Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if treatment with CK-0045 improves blood sugar control after a meal in participants with type 2 diabetes mellitus (T2DM) and overweight/obesity. It also aims to learn if CK-0045 can reduce body weight in these patients. The main question it aims to answer is: • Does 16 weeks of treatment with CK-0045 improve blood sugar control after a meal in participants with overweight or obesity and T2DM? Researchers will compare two dose levels of CK-0045 to a placebo arm (a look-alike substance that contains no drug) to see if CK-0045 improves blood sugar control. Participants will: * Have CK-0045 or placebo injected subcutaneously (under the skin) once weekly over a period of 16 weeks. * Visit the clinic 24 times and stay overnight at 2 of the visits. * During the visits blood samples will be collected and several other assessments/examinations will be performed to learn about the effects (and potential side effects) of CK-0045. |
MARC STOFFEL; | 2024-09-16 |
| 168 | Continuous Glucose Monitoring Paired With Remotely Delivered Behavior Change Technique Interventions for Glycemic Management and Diabetes Distress Among Adults With Type 2 Diabetes Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to use a Personalized Trial (N-of-1) design to test the effect of an intervention that pairs continuous glucose monitoring (CGM) with text message-delivered behavior change interventions for physical activity and mood on outcomes of glycemic regulation and diabetes distress among adults with type 2 diabetes and diabetes distress. Participants (n=60) will be given CGM sensors and a FitBit watch to wear during the 10-week study. Participants will complete a two-week baseline/run-in period, during which the participants usual blood glucose and physical activity will be monitored. After successful completion of the run-in period, … |
NORTHWELL HEALTH | 2024-09-10 |
| 169 | Association Between Molar Incisor Hypomineralization And Type I Diabetes Milletus: A Cross Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: – Determine the association between molar incisor hypomineralization and type I diabetes millutes, its severity and treatment need via clinical examination of children with type I diabetes millutes . – Teeth will be cleaned gently using gauze and wet with saliva during examination. A disposable diagnostic set (mirror, probe) will be used for each patient where mirrors will be used for proper visualization especially for maxillary teeth. – Blunt explorers will be used to aid in tactile sensation if needed, … |
MARIAM SAMIR FAHMY AUOB; | 2024-09-01 |
| 170 | A Phase 1 Study to Evaluate The Pharmacokinetics, Safety, and Tolerability of Single Ascending Oral Doses of GS-4571 in Healthy Participants, Multiple Ascending Oral Doses of GS-4571 in Nondiabetic Obese Participants and Nonobese Participants With Type 2 Diabetes Mellitus (T2DM), and to Evaluate The Effect of Food and An Acid-Reducing Agent on Pharmacokinetics of GS-4571 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to learn more about the study drug, GS-4571, and how safe it is in 3 groups, i) Healthy participants, ii) Healthy non-diabetic obese participants, and iii) Non-obese participants with Type 2 Diabetes Mellitus (T2DM). The primary objectives of this study are: * To characterize the pharmacokinetics (PK) of GS-4571 following single and multiple ascending oral doses of GS-4571. * To evaluate the effect of concomitant food intake and (if conducted) a representative acid-reducing agent (proton pump inhibitor (PPI), … |
GILEAD SCIENCES | 2024-08-28 |
| 171 | IMPACT of DIABETES HEALTHCARE PROGRAM on GLYCEMIC CONTROL and SELF-EFFICACY AMONG TYPE-II DIABETICS in ISLAMABAD PAKISTAN PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 2 Diabetes Mellitus (T2DM) is a significant public health challenge in Pakistan, characterized by a growing prevalence and substantial economic burden. The alarming rise in T2DM cases in Pakistan highlights the need for evidence-based solutions to control the disease. However, there is a notable knowledge gap in the effectiveness of diabetes healthcare program interventions in Pakistan. The goal of this randomized controlled trial (RCT) is to evaluate the effectiveness of a Diabetes Healthcare Program in improving glycemic control and enhancing Self-efficacy in Type-II Diabetic patients in Islamabad, … |
ABDUL SAMAD; | 2024-08-26 |
| 172 | Phase 2 Research Study for Type 2 Diabetes Mellitus Through Digital Therapeutics PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is conducted to evaluate the effectiveness of Digital therapeutics (DTx) in managing patients with Type 2 Diabetes Mellitus (T2DM) by delivering digital lifestyle interventions through a national health application (BruHealth). |
CHONG PUI LIN; | 2024-08-20 |
| 173 | The Value of Using Colostrum Supplements on The Physical Performance and Cognitive Function in Healthy Subjects and Type 2 Diabetes: A Case-management Comparative Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional Randomized clinical is to compare the effect of colostrum pharmaceutical preparation and placebo in a sample of Iraqi participants. The main questions to answer are: 1. What are the effects of the tested regimens on the level of IL-1 and IL-15. 2. What are the effects of the tested regimens on the Fasting Blood glucose? 3. What are the effects of the tested regimens on the HbA1C? 4. What are the effects of the tested regimens on the Body Mass Index? 5. What are the effects of the tested regimens on the Lipid profile? 6. What are the effects of the tested regimens on C-reactive protein? 7. What are the effects of the tested regimens on Hematological indices? 8. What are the effects of the tested regimens on Rate pressure product? Participants will be separated into four groups: 1. Group 1 (Healthy control): 24 Patients, will be receiving Placebo Capsule per oral once daily for 60 days 2. Group 2 (Healthy control) : 26 Patients, will be receiving Colostrum Capsule 500 mg per oral once daily. 3. Group 3 (Diabetes Type 2): 23 Pateins, will be receiving Placebo Capsule per oral once daily for 60 days 4. Group 4 (Diabetes Type 2) : 27 Patients, will be receiving Colostrum Capsule 500 mg per oral once daily. Researchers will compare Groups 1,2,3, and 4 to observe the effect of the tested treatment regimens on Fasting Blood Glucose, HbA1c, Lipid profile, Rate pressure product, C-reactive protein, Hematological indices, and Body Mass Index. and use these measures In special formulas to determine the effect of the tested regimens on physical performance and cognitive function. |
HAYDER ADNAN FAWZI; | 2024-08-20 |
| 174 | Safety and Efficacy of Once-weekly Subcutaneous and Once-daily Oral NNC0487-0111 in Participants With Type 2 Diabetes – A Dose Finding Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will look at how well different doses of a new medicine called NNC0487-0111 help lower the blood sugar and body weight in people with type 2 diabetes. NNC0487-0111 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. Participants will either get NNC0487-0111, which is given as tablets or as injections, or placebo. Which treatment the participant get is decided by chance.The study will last for about 43 weeks. |
NOVO NORDISK | 2024-08-07 |
| 175 | Investigation of The Safety, Tolerability, Pharmacokinetics and Efficacy of Subcutaneous Weekly Doses of NNC0519-0130 in Participants With Obesity and in Participants With Type 2 Diabetes With Either Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A new study medicine called NNC0519-0130 to improve treatment options for people living with excess body weight, with or without type 2 diabetes. The purpose of the study is to investigate potential side effects and blood levels of NNC0519-0130, as well as changes in body weight, blood sugar levels, and heart activity. The study consists of two groups, with participants receiving either the study medicine (NNC0519-0130) or a placebo. Which treatment participants get is decided by chance and they can only participate in one group. Participants will be given the study medicine once weekly, … |
NOVO NORDISK | 2024-08-07 |
| 176 | Glucagon-like Peptide-1’s Effect on Renal Regional Blood Flow and The Renal Function in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this double-blinded, placebo-controlled, randomized, crossover study is to examine the effect of semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), on renal hemodynamics and function in patients with type 2 diabetes mellitus (T2DM) and moderate chronic kidney disease (CKD). The study will determine the effects of semaglutide on: – Renal arterial blood flow, regional renal perfusion, and oxygenation – Activity of the renin-angiotensin-aldosterone system (RAAS) – The glomerular filtration rate (GFR) – Sodium excretion in urine – Blood pressure and heart rate |
ALI ASMAR; | 2024-08-01 |
| 177 | Examining The Preliminary Efficacy of An In-Person Lifestyle Intervention for Black Female Adolescent/Caregiver Dyads at Risk for Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to look at changes in diabetes-related risk factors in Black adolescent girls who are at risk for type 2 diabetes and their primary female caregiver after both participating in a 12-week in-person lifestyle program. |
TASHARA M LEAK; | 2024-08-01 |
| 178 | Breathing New Life: The Impact of Incentive Spirometer Training on Rehabilitation and Health in Type 2 Diabetes With Sarcopenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In patients with Type 2 diabetes, the risk of developing sarcopenia is three times higher compared to individuals with normal blood sugar levels. Sarcopenia is often accompanied by reduced physical activity, immobility, slow gait, and poor endurance. More importantly, previous studies have shown that sarcopenia leads to a decrease in mobility, which in turn results in reduced cardiopulmonary function, difficulty in breathing, and subsequently even less activity. In diabetic patients, this can cause poor control of blood sugar and lipids, as well as sarcopenic obesity, creating a vicious cycle. Therefore, … |
YU-SHAN HSIEH; | 2024-08-01 |
| 179 | BGEM Use As Blood Glucose Prediction Model in T2DM Population of Indonesia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Using signals from consumer-grade PPG sensors on wrist wearables, smart rings or hearables, BGEM® AI model computes the relevant digital biomarkers correlated with the change of blood glucose level to predict a blood glucose result for monitoring and evaluating diabetic risks Ukrida in collaboration with Actxa & Lif aims to enhance the current model’s prediction accuracy to predict the blood glucose levels of individuals almost as accurately as a glucometer. To achieve this, Actxa aims to collect data from around 500 individuals with diabetes in this exercise and 400 healthy or undiagnosed (prediabetes/diabetes) individuals. |
KRIDA WACANA CHRISTIAN UNIVERSITY | 2024-07-30 |
| 180 | Efficacy and Safety of Pueraria Lobata Radix As An Adjuvant Treatment for Type 2 Diabetes Mellitus: A Multicenter, Randomized, Double-blinded, Placebo-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: As a dietary herb, pueraria lobata radix (PLR) has been showed to have hypoglycemic effects in animal experiments. However, there is currently a lack of evidence from randomized controlled trials. Therefore, this randomized, double-blind, placebo-controlled trial aims to assess the efficacy and safety of PLR as an adjunctive treatment for type 2 diabetes mellitus (T2DM). |
XU ZHOU; | 2024-07-25 |
| 181 | A Randomized, Double-blind, Placebo-controlled Study to Assess The Effect of Glucocil® on Metabolic Health in Individuals With Prediabetes and Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, double-blind, placebo-controlled study to assess the effect of Glucocil® on metabolic health in individuals with prediabetes and Type 2 Diabetes Mellitus. |
VEDIC LIFESCIENCES PVT | 2024-07-25 |
| 182 | Study on The Use of Digital Platforms for The Control of Insulin Treatment in Patients With Type 1 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 1 diabetes mellitus is a chronic pathology and represents a constant challenge for children and adolescents with diabetes and their families. The objective of the treatment of DM1 in pediatric age is to achieve and maintain an optimal glycemic control in order to avoid or delay chronic micro- and macrovascular complications related to the disease. However, currently, despite technological advances and the development of new insulin formulations, the majority of patients are unable to achieve glycemic goals. In this context, … |
PERSEI VIVARIUM | 2024-07-22 |
| 183 | Real World Effectiveness of Oral Semaglutide in Thailand Patients With Type 2 Diabetes: An Observational, Multicentre, Retrospective Cohort Study REAL-world Effectiveness of Oral Semaglutide In A Cohort of Thai PatientS With Type 2 Diabetes TreatED With Oral Antidiabetic Medications (REALISED) Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to describe the effectiveness of oral semaglutide on glycemic control and body weight control and describe characteristics of type 2 diabetes (T2D) adult patients who are being treated with oral semaglutide in Thailand. Data of eligible patients with T2D will be collected via electronic medical record or paper-format chart review to assess the effectiveness of oral semaglutide. Total study duration for the individual patient will be six months from baseline. The study duration expands within the window period will be 12 months from baseline which will be the optional visit. |
NOVO NORDISK | 2024-07-15 |
| 184 | To Investigate The Effects of Low Glycemic Index（LGI）Related Steamed Bread on Glycemia Control, Islet Function in Patients With Type 2 Diabetes in China: A Single-center, Randomized, Open-label, Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a single-center, randomized, open, prospective, parallel-controlled, head-to-head comparison trial. To investigate the effects of low glycemic index（LGI）related steam bread on glycemic control，islet function in patients with type 2 diabetes. |
LIANYONG LIU; | 2024-07-13 |
| 185 | Insulin Initiation and Adherence Behaviours: A Cross Sectional Survey of Indian HCPs & Patients With Type 2 Diabetes PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a cross-sectional study planned among patients with Type 2 Diabetes (T2D) and Health Care Providers (HCPs) who treat T2D patients. Study participants will be recruited through existing databases/panels to complete a 30-minute self-administered online survey. The purpose of the study is to understand the insulinization barriers and the insulin adherence behaviours of both HCPs and patients. |
NOVO NORDISK | 2024-07-05 |
| 186 | Safety and Efficacy Assessment of Unani Formulation ‘Dolabi’ in Management of Diabetes Mellitus Type II PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes is a chronic health condition that affects millions of people worldwide. In recent years, Pakistan has witnessed a significant increase in the prevalence of diabetes, making it a major public health concern. To address this growing problem, conducting clinical trials on diabetes in Pakistan is of utmost importance. Clinical trials play a crucial role in advancing medical knowledge, improving patient care, and finding effective treatments for diabetes. This research aims to assess the safety and effectiveness of the Unani formulation Dolabi in treating type II diabetes mellitus. The study consists of two phases: a pre-clinical phase, … |
ABDUL BARI; | 2024-07-04 |
| 187 | Unrecognised Comorbidity Detection in Hospitalised Patients (CODETECT) PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: Over two million people in the UK are unaware that they’re living with a long-term (chronic) health condition, such as diabetes or a heart problem. These chronic conditions can lead to serious complications such as heart attacks, strokes, and kidney problems. By diagnosing these conditions earlier, effective treatments can be started sooner which will reduce the risk of harm. However, diagnosis relies on people having symptoms and contacting their doctor or attending NHS Health Checks. There are over 16 million admissions to English hospitals each year. Hospitals collect a lot of information during a hospital stay including patients’ age, … |
PETER WATKINSON; | 2024-07-01 |
| 188 | Sarcopenic Index and Related Factors in Patients With Type 2 Diabetes Applying to Tertiary Health Care Services PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is particularly common in individuals with T2DM and is often associated with insulin resistance, chronic inflammation and oxidative stress. The Sarcopenia Index (SI), calculated as serum creatinine divided by serum cystatin C, is a practical tool for assessing sarcopenia and is used in many clinical settings. In this study, we aimed to investigate the relationship between sarcopenic index and variables such as age, diabetes duration, diabetes control and complication-related parameters such as NT-proBNP and Fib4 score in patients with type 2 diabetes. |
AYSE N ERBAKAN; | 2024-07-01 |
| 189 | Insulin Injection Practices in People With Diabetes in Spain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this era of pharmaceutical and technological advancements, gaining insights into prevalent insulin administration practices under real-life conditions becomes pivotal for healthcare professionals. The investigators aim to explore insulin injection habits through an online survey among a broad, unselected group of participants with type 1 and type 2 diabetes undergoing daily prandial and/or basal insulin treatment. Eligible participants will access and complete the survey at their convenience after providing online informed consent within the study period |
FRANCISCO JAVIER AMPUDIA BLASCO; | 2024-07-01 |
| 190 | Type 2 Diabetes Post Exercise Arterial Stiffness PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aim of this research proposal is to determine the impact of GLP1 agonists on post-exercise arterial stiffness. Therefore, the investigators will examine the cardiovascular responses to exercise in individuals with Type 2 Diabetes mellitus (T2DM) taking these medications during and following a graded maximal exercise test. |
RONALD E JACKSON; | 2024-07-01 |
| 191 | Benefits of Smart Pens in People With Type 1 Diabetes: A Real-word Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to address persistent challenges in achieving recommended control goals for patients with type 1 diabetes through innovative interventions. Specifically, the research focuses on assessing the effectiveness of smart insulin pens combined with glucose monitoring devices as a promising treatment option for individuals on multiple daily insulin injections. The study will analyze electronic health records from adults (≥ 18 years) attending the Diabetes Unit of the University Clinical Hospital of Valencia. Participants who are or have used smart insulin pens will be compared with a control group matched for age, sex, duration of diabetes, … |
FRANCISCO JAVIER AMPUDIA BLASCO; | 2024-07-01 |
| 192 | Diabetes Link Discord PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to examine the impact of an online peer support group in Children’s Mercy teens with Type 1 Diabetes. The main objectives are to examine the feasibility and acceptability of the Diabetes Link’s online social platform Discord among youth with diabetes as it relates to peer support, diabetes management, and usability and to examine the efficacy/magnitude of the effect of the Discord group on treatment adherence among youth with diabetes. Participants will participate in an online peer support group for 3 months and provide their feedback while doing so. |
MARK CLEMENTS; | 2024-07-01 |
| 193 | Effects of A Health Education Intervention Based on The Behaviour Change Wheel on Fear of Hypoglycemia in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine the effects of a health Education Intervention based on the Behaviour Change Wheel (BCW) theory on fear of hypoglycemia and relevant outcomes of type 2 diabetic patients. |
ZHAO YUEQI; | 2024-07-01 |
| 194 | Efficacy of On-venous Laser Irradiation of Blood on Diabetes Kidney Disease Patients: A Single Center, Randomized, Assessor- and Participant-blind, Controlled, Cross-over Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The single center, randomized, assessor- and participant-blind, controlled, cross-over on-venous laser irradiation of blood clinical trial was performed to analyze patients with DKD. The information will help to whether integration of laser acupuncture into patient care will help to improve the clinical symptoms and quality of life. |
YU-CHEN LEE; | 2024-07-01 |
| 195 | Happy Bob App: A Preliminary Evaluation of Its Use in Youth With Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the impact of peer support via the Happy Bob phone app in youth with Type 1 Diabetes. The main questions it aims to answer are: What is the usability and acceptability of the app? What is the app’s efficacy on measures such as treatment adherence and social support? And how are these effects impacted by remote patient monitoring by clinic staff? Participants will use the Happy Bob app for 6 months and will complete a series of surveys at the start, middle, … |
MARK CLEMENTS; | 2024-07-01 |
| 196 | Effects of Anti-Stigma Psychoeducation Based on Roy Adaptation Model on Stigma and Quality of Life in Individuals With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aimed to examine the effects of anti-stigma psychoeducation based on the Roy Adaptation Model on stigma and quality of life in individuals with Type 1 Diabetes.The main questions it aims to answer are: 1. Does anti-stigma psychoeducation reduce stigma of individuals diagnosed with Type 1 Diabetes? 2. Does anti-stigma psychoeducation improve the quality of life of individuals diagnosed with Type 1 Diabetes? Researchers will compare the group that did not receive stigma prevention psychoeducation with those that did. Participants will receive 7 sessions of the psychoeducation once a week. An evaluation session will be administered 3 months after the psychoeducation. Researchers will assess all participants’ stigma and quality of life before, after and 3 months after the psychoeducation. |
ECE MUTLU SATIL; | 2024-07-01 |
| 197 | Effects of Telerehabilitation Exercise Program on Maternal Quality of Life, Fetal and Neonatal Health Outcomes in Women With Gestational Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Gestational diabetes mellitus (GDM) occurs when blood sugar levels rise during pregnancy, typically between 24-28 weeks, affecting about 2-18% of all pregnancies. It is a common metabolic disease that can lead to health risks for the mother, fetus, and child, and can negatively impact the mother’s quality of life. This study aims to explore how a telerehabilitation exercise program affects the quality of life of mothers with GDM and the health of fetus/neonate. |
HUMA RIAZ; | 2024-07-01 |
| 198 | A Phase 2, Randomized, Double-blind, Placebo Controlled, Parallel Group Study to Evaluate The Efficacy and Safety of HDM1002 Tablets in Subjects With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin or Diet and Exercise PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, placebo controlled, parallel group study, which aims to provide data on efficacy, safety and pharmacokinetics (PK) of multiple dose levels of HDM1002 tablets in adults with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin and/or diet and exercise. |
YIMING MU; | 2024-06-30 |
| 199 | A Pilot Study Investigating The Effect of Patient Support Solution App With Connectivity on Once-weekly Semaglutide S.c. Treatment Persistence in Patients With Type 2 Diabetes in A Clinical Practice Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study looks at how participants with type 2 diabetes take Ozempic® and if the Ozempic® app helps participants to stay on this treatment. Participants will already be prescribed with Ozempic® by the study doctor. Participants may be asked to use a device called Mallya®, which participants must attach to their Ozempic® injection pen. Participants might also be asked to install an Ozempic® app on their mobile phone which supports the participants in the use of Ozempic®. At the beginning and at the end of this study, … |
NOVO NORDISK | 2024-06-26 |
| 200 | Diabetes in Primary Care – Improving Classification (DePICtion) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the clinical utility and acceptability to patients and practitioners of running diabetes classification algorithms on primary care data to help improve diagnosis of diabetes subtypes in adults diagnosed with diabetes under the age of 50. The outputs from this research will help provide initial data on how best to use these algorithms in primary care and the optimal design of a decision support tool that could be taken forward to a full trial. |
BEVERLEY SHIELDS; | 2024-06-25 |
| 201 | The Medically Reproducing Bariatric Surgery (MRB) II Study: SEMAGLUTIDE Followed By OPTIFAST in Veterans With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Roux-en-Y (RYGB) gastric bypass reduces the size and capacity of the stomach and bypasses a portion of the small intestine which leads to decreased food intake and higher levels of a gut hormone called GLP-1 (glucagon-like-peptide-1). These changes lead to weight loss, … |
MOAHAD DAR; | 2024-06-24 |
| 202 | EFFICACY OF DIACEREIN ADDITION ON INTERLEUKIN-1Β, HS-CRP, TNF-Α LEVELS AND GLYCEMIC CONTROL IN UNCONTROLLED TYPE 2 DIABETES MELLITUS PATIENTS AT DR. MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if diacerein supplementation can help improve inflammation and glycemic control in adults with uncontrolled type 2 diabetes. It will also study the safety and tolerability of diacerein. The main questions it aims to answer are: * Does diacerein lower levels of inflammatory markers like interleukin-1β, hs-CRP, … |
YULIANTO KUSNADI; | 2024-06-21 |
| 203 | Effect of Video-Based Health Education Intervention on Insulin Therapy Among Adults With Diabetes Mellitus in Dhulikhel Hospital: A Randomized Controlled Trial This Research Aims to Investigate The Effectiveness of Video-based Health Education in Supporting Insulin Therapy in Diabetes Mellitus Patients Visiting Dhulikhel Hospital. With The Increasing Patients With Insulin Therapy and The Need for Effective Patient Education, It Is Essential to Evaluate The Impact of Video-based Educational Interventions Specifically Tailored for Patients Undergoing Insulin Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Insulin is an essential therapy for treating diabetes, but many patients lack standard insulin injection skills. Learning the method of proper insulin injection technique is crucial for diabetes patients as it promotes treatment compliance, ensures safety, improves treatment efficacy, and contributes to better overall health outcomes. Adequate training and understanding of the proper technique enhance patient self-efficacy and empower them to take an active role in managing their diabetes mellitus. It empowers patients to effectively manage their diabetes and maintain optimal blood glucose control, … |
SUBINA MANANDHAR; | 2024-06-15 |
| 204 | Based on A Randomized, Double-blind, Controlled Trial, Evaluate The Effects of Probiotics on Inflammation and Metabolism in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study aims to explore the effects of probiotics on inflammatory and metabolic indicators in patients with type 2 diabetes. By assessing the potential of probiotics to modify these markers, the study seeks to identify an economical and effective strategy for the prevention and treatment of type 2 diabetes. |
WECARE PROBIOTICS | 2024-06-15 |
| 205 | Impact of Diabetes Mellitus on Retinal Microvasculature in Patients Without Clinical Retinopathy Using Optical Coherence Tomography Angiography PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: the aim of this study is to assess the impact of duration of DM on OCTA parameters in diabetic patients without clinical Diabetic retinopathy. |
MOHAMED ABDOU SAEED; | 2024-06-10 |
| 206 | Investigating The Effects of Curcumin and Saffron on Fertility, Sugar, Lipid and Anthropometric Indicators in Women With Diabetes Mellitus of Reproductive Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ## Study Hypotheses Summary: **Primary Hypothesis:** Women with diabetes mellitus receiving the intervention will exhibit significantly lower levels of sugar indicators (FBS, HA1c, 2HPP) and lipid indicators (LDL, HDL, TG) compared to the placebo group. **Secondary Hypotheses:** 1. **Psychological Outcomes:** The intervention group will show significant reductions in stress, anxiety, and depression compared to the placebo group. 2. **Sexual Health Outcomes:** The intervention group will experience improvements in sexual performance, marital satisfaction, … |
FATEME MOSHIRENIA; | 2024-06-10 |
| 207 | Effects of Telerehabilitation Exercise Program on Maternal Antenatal Glycemic Control in Women With Gestational Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Gestational diabetes is in which high blood glucose concentration results from body’s inability to create enough insulin to fulfil the needs of pregnancy. It appears in week between 24 to 28 and and raises the mothers and Childs risk of problems. It is thought to affect about 1 in 7 pregnancies worldwide. Through these remote exercise sessions the study evaluates the effectiveness of tele rehabilitation in improving glycemic management during pregnancy.The results will help clarify how telehealth intervention can best support GDM patient’s maternal health outcomes. |
HUMA RIAZ; | 2024-06-10 |
| 208 | Comparative Efficacy and Safety of Sitagliptin Plus Gliclazide SR Versus Metformin in Treatment-Naïve Type 2 Diabetes Patients: A Randomized Non-Inferiority Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares the efficacy and safety of sitagliptin phosphate combined with gliclazide sustained-release tablets versus metformin in treatment-naïve patients with type 2 diabetes mellitus (T2DM) and glucotoxicity. The trial assesses glycemic control, patient compliance, and adverse events over a 12-week period using a randomized controlled design to determine the non-inferiority of the combined treatment. |
ZHIBIN XU; | 2024-06-01 |
| 209 | Developing and Testing A Self-Compassion Tool Kit to Improve The Care of Individuals With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is a high prevalence of anxiety and depression in patients with Type 2 Diabetes (T2D). While past studies demonstrate the potential therapeutic effect of mindfulness-based interventions in patients with T2D, little is understood about the mode of delivery or quantity of the intervention necessary to experience benefits. This project aims to develop and implement a self-compassion tool kit based on the principles of mindfulness and meditation to better understand how self-compassion works to affect psychological health and wellbeing in patients with T2D. The investigators will study the impact of a self-compassion tool kit – including mindfulness meditation, exercise, … |
EDWARD CHAO; | 2024-06-01 |
| 210 | Teamwork, Targets, Technology, and Tight Control in Newly Diagnosed Pediatric T1D: 4T Sustainability Program PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the 4T program is to implement proven methods and emerging diabetes technology into clinical practice to sustain tight glucose control from the onset of type 1 diabetes (T1D) and optimize patient-reported and psychosocial outcomes. The investigators will expand the 4T (Teamwork, Targets, Technology, and Tight Control) program to all patients seen at Stanford Pediatric Diabetes Endocrinology as the standard of care. Disseminating the 4T program as the standard of care will optimize the benefits of diabetes technology by lowering HbA1c, improving PROs, and reducing disparities. |
DAVID MAAHS; | 2024-05-30 |
| 211 | Tandem Freedom – Feasibility Trial 1 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This feasibility study is a prospective, single arm study evaluating the Tandem Freedom system in adults with type 1 diabetes. Existing Control-IQ technology users will use Control-IQ technology at home for a 1 week run-in, then will use Tandem Freedom in a supervised hotel setting for 3 days/nights. |
MARTIN DE BOCK; | 2024-05-29 |
| 212 | Key Finding of DM Treatment with Combination, A MuLticenter, Randomized, Parallel, Gathering Information of Phase 4 Trial to Evaluate The Efficacy and Safety of Dapagliflozin or Pioglitazone Add-on to Metformin and DPP-4 Inhibitor in Patients with Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Key finding of DM Treatment with combination, A MuLticenter, Randomized, Parallel, Gathering Information of phase 4 Trial to Evaluate the Efficacy and Safety of Dapagliflozin or Pioglitazone add-on to Metformin and DPP-4 inhibitor in Patients with Type 2 Diabetes Who Have Inadequate Glycaemic Control on a Background Combination of Metformin and DPP-4 inhibitor(KLIMT Study) |
DONG WHA PHARMACEUTICAL | 2024-05-28 |
| 213 | Effects of Moderate Carbohydrate Consumption on Metabolic and Obstetric Outcomes in Pregnant Women with Insulin-treated Diabetes- A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes during pregnancy increases maternal and fetal complications, necessitating optimal glycemic control. The standard care diet (SCD, ≥175g/day carbohydrate) lacks robust evidence, particularly for pregnancies requiring intensive insulin treatment (IIT). This RCT investigates whether a moderate carbohydrate diet (MCD, ≤120g/day) versus SCD improves glycemic control and alters metabolomic profiles in pregnant individuals on IIT. Aims: To compare the efficacy and safety of a SCD versus MCD on glycemic control, metabolomic signatures, and pregnancy outcomes in pregnant individuals on IIT. |
GENYA AHARON HANANEL; | 2024-05-28 |
| 214 | The Hope App: An Immersive Telehealth Solution for Older Adults With Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research study will test how a computer program (called the Hope App) teaches diabetes care skills for older adults with diabetes. The study will compare those who receive diabetes education (10 educational modules and monthly health coaching) through the research program with those who receive care as usual. |
SUZANNE MITCHELL; | 2024-05-24 |
| 215 | The Establishment of Empowerment-based Complementary and Alternative Medicine (ECAM) Educational Program to Improve Complementary and Alternative Medicine(CAM) Health Literacy in Patients With Diabetes: Dilemma Analysis, Integration Into Practice and Outcome Evaluation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase study will use a randomized trial method to evaluate the performance of the ECAM educational app in the promotion of CAM health literacy and communication among patients with diabetes. |
HSIAO-YUN CHANG; | 2024-05-17 |
| 216 | Effectiveness of Educational Intervention on Footcare Among Individuals Having Type 2 Diabetes at Slums of Karachi, Pakistan. A Randomize Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There are multiple studies conducted in Pakistan that supports the topic of foot care knowledge among individual with type 2 diabetes but all are descriptive cross-sectional studies and investigators cannot develop cause effect relationship out of it. Secondly, there is a lack of documented research on the foot care knowledge shown by people with T2D residing in the slums of Karachi. In order to assess the knowledge intervention among the individual having T2D through qualified diabetes educators and pictorial educational pamphlet along with the standard care of treatment. Consequently, … |
HINA SHARIF; | 2024-05-15 |
| 217 | Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease. |
ANAND VAIDYA; | 2024-05-15 |
| 218 | A Three-Part, Randomized, Double-Blind (Part A) and Open-Label (Part B and Part C), Multi-Dose, Phase 1 Study to Assess The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to look at the amount of the study drug LY3938577 that gets into the blood stream and how long it takes the body to get rid of it. At a later stage of this study (part B and C) the blood sugar lowering effect and the duration of action of LY3938577 will be evaluated compared to Insulin Degludec. The study will also evaluate the safety and tolerability of LY3938577 and information about any side effects experienced will be collected. The study will be conducted in three parts (A, B, … |
OLIVER KLEIN; | 2024-05-15 |
| 219 | The Effect of Automated Insulin Delivery on Sleep Compared to Multiple Daily Injections in Pediatric Patients With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to learn about the effect of insulin pumps on sleep in pediatric patients with type 1 diabetes and their caregivers. We are hoping to find out if insulin pumps improve sleep, worsen sleep, or have no effect at all. We are hoping to also explore the relationship between insulin pumps, sleep, … |
RACHEL PALTING; | 2024-05-15 |
| 220 | IHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults with Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research study aims to test a financial and health insurance iHERO Toolkit for young adults with type1 diabetes. The iHERO Toolkit was developed over one year with the type 1 diabetes community, The Diabetes Link organization, and experts. Now, the investigators want to understand the impact of the iHERO Toolkit on diabetes self-management, financial stress, … |
JULIA BLANCHETTE; | 2024-05-14 |
| 221 | Prevalence and Management Practice of Diabetic Kidney Disease at BADAS Affiliated Healthcare Centres in Bangladesh – An Exploratory Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Diabetes is a growing public health concern in Bangladesh, with millions affected. Diabetic Kidney Disease (DKD) is a severe complication of diabetes, affecting approximately 21.3% of the diabetic population. To address this issue, a comprehensive assessment of DKD within the Bangladesh Diabetic Association's (BADAS) affiliated healthcare centres is necessary. Objective: The study's general objective is to determine the prevalence of DKD and evaluate its management at BADAS-affiliated healthcare centers. Specific objectives include assessing risk factors, screening practices, disease staging, management approaches, patient education, and providing evidence-based recommendations. Methodology: – Study Design: Cross-sectional – … |
WASIM MD MOHOSIN UL HAQUE; | 2024-05-11 |
| 222 | A Randomized, Open-label, Parallel, Treat to Target Study Comparing The Efficacy and Safety of HR17031 Injection With Insulin Glargine in Patients With Type 2 Diabetes Inadequately Controlled With Basal Insulin, Metformin in Combination With or Without One Other Oral Antidiabetic Drug (OAD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the efficacy and safety of HR17031 injection and insulin glargine, including the changes of efficacy indicators such as HbA1c, fasting blood glucose, body weight and safety indicators such as adverse events and hypoglycemic events. |
JIANGSU HENGRUI MEDICINE | 2024-05-08 |
| 223 | A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of NA-931 in Overweight/Obese Participants and in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, double-blind, placebo-controlled, dose escalation, first in human study designed to assess the safety and tolerability, pharmacokinetics, and pharmacodynamics of NA-931 when administered as single and multiple-ascending doses in overweight/obese participants and as multiple doses in patients with T2DM. |
BIOMED INDUSTRIES | 2024-05-06 |
| 224 | A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot, genotype-stratified clinical trial aims to investigate the safety and preliminary efficacy of berberine supplementation in adult patients with type 2 diabetes mellitus (T2DM) who carry a specific high-risk TCF7L2 polymorphism (e.g., rs7903146) in the homozygous state. The study will compare improvements in glycemic control and metabolic markers between two groups: (1) homozygous carriers of the TCF7L2 unfavorable variant and (2) non-carriers (wild-type). It is hypothesized that berberine will yield greater reductions in HbA1c and fasting plasma glucose among homozygous carriers, potentially due to their distinct TCF7L2-mediated insulin secretion and sensitivity pathways. |
S LAB SOLOWAYS | 2024-05-03 |
| 225 | Pragmatic Clinical Trial of Continuous Glucose Monitoring-based Interventions for Safe Insulin Use in High-Risk Older Adults With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Older adults with type 2 diabetes are at higher risk for severe hypoglycemia and its related complications (including hospitalization and death) when taking insulin. This study proposes to evaluate, in a randomized clinical trial, a strategy of safe insulin prescribing based on an educational program that leverages continuous glucose monitoring to support older adults at high risk for hypoglycemia. If the aims of this project are achieved, this novel care strategy could be widely applied to reduce severe hypoglycemia episodes in older, high-risk adults with type 2 diabetes. |
RICHARD W GRANT; | 2024-05-01 |
| 226 | A Multicenter, Randomized, Double-blind, Sham-controlled Study for Assessing The Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes (ReCET Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to evaluate the safety and effectiveness of endoscopic intestinal re-cellularization therapy in individuals with type 2 diabetes (T2D) inadequately controlled on non-insulin glucose-lowering medications. |
ENDOGENEX | 2024-05-01 |
| 227 | Effectiveness and Safety of The RIGHTEST™ Continuous Glucose Monitoring System for Blood Glucose Management in Persons With Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The trial is expected to enroll 120 confirmed cases of type 1 or type 2 diabetes. All eligible subjects must wear a continuous glucose monitoring system on both the left and right upper arms for a maximum of 15 days (360 hours) and adhere to the clinical visit protocol. The entire trial process consists of pre-screening visits, 5 clinical visits, and 1 telephone follow-up. After enrollment, … |
BIONIME | 2024-05-01 |
| 228 | The Effect of Adherence to Oral Semaglutide on Glycaemic Control in People With Type 2 Diabetes Treated With Metformin (DIACRON) – An Open-label Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the trial is to investigate the effect of adherence to oral semaglutide dosing instructions on glycaemic control in people with type 2 diabetes, which are dysregulated on metformin and naïve to second line antidiabetic treatment. |
PETER VESTERGAARD; | 2024-05-01 |
| 229 | COntinuous Glucose Monitoring, Contingency Management, and Motivational InTerviewing for Patients With TypE 2 Diabetes in Kansas City PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is evaluating a behavioral treatment program that uses diabetes coaching and financial rewards in addition to continuous glucose monitoring to improve diabetes management in adult patients with type 2 diabetes. This study will evaluate if this behavioral treatment program increases individual adherence to a diabetes treatment plan and improves blood sugar management. |
JARED BRUCE; | 2024-05-01 |
| 230 | Personalized Nutrition Therapy Using Continuous Glucose Monitoring to Improve Outcomes in Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Nutrition guidelines state that multiple eating patterns are effective for type 2 diabetes and that therapy should be individualized. Yet many nutrition plans fail to account for interpersonal variability in blood glucose response to meals. This diminishes the ability of dietary interventions to optimize glycemic control and may lessen patient satisfaction, self–efficacy, and adherence. Continuous glucose monitoring (CGM) can facilitate behavior change in type 2 diabetes and has been associated with improved outcomes in nutrition intervention studies; this literature is limited by small study sample sizes and heterogeneity of study design and outcomes, … |
ANNE BANTLE; | 2024-05-01 |
| 231 | Collaborative Solutions for Breaking Up Sedentary Time in Black Older Adults With Type 2 Diabetes: The Interrupt Diabetes Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The disparate burden of Type 2 Diabetes (T2D) faced by Black individuals makes attention to preventing or delaying the development of T2D and its associated cardiovascular (CV) complications, essential. Similar to differences in cardiovascular disease (CVD) rates across racial and ethnic groups of older people, there are differences in engagement in physical activity (PA), a significant contributor to CVD. Black adults are less likely to engage in physical activity PA than their non-Hispanic White peers, with 26.7% of Black Minnesotans reporting that they did not engage any leisure-time PA in the past month, … |
MARY O WHIPPLE; | 2024-05-01 |
| 232 | Fully Decentralised Clinical Study Exploring Remote Collection of Glycaemic and Behaviometric Data Among Participants With Type 2 Diabetes Mellitus on Different Treatment Regimens PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Earlier protocol ID was NN1250-4630, protocol ID is changed to NN1535-7774. The purpose of this study is to collect blood glucose values and activity data in patients with type 2 diabetes for approximately 12 weeks using electronic devices in a full virtual clinical setting. Virtual clinical setting means that all data are collected by use of participants’ personal smartphone and study-related apps. In other words, … |
NOVO NORDISK | 2024-04-30 |
| 233 | The Evaluation of The Efficacy and Safety of Switching to Once-daily IDegLira in Patients With Type 2 Diabetes Receiving Premixed Insulin Therapy, A Multi-center, Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to evaluate the efficacy and safety of IDegLira in type 2 diabetes who have failed premixed insulin therapy. The study plans to enroll 256 participants with inadequate glycemic control despite twice-daily subcutaneous injections of premixed insulin and metformin. Participants will be randomly assigned to either the premixed insulin dose optimization group (control group) or IDegLira once daily group, and the difference in change in glycated hemoglobin levels from baseline to 16 weeks of treatment will be assessed between the two groups. |
WEI LIU; | 2024-04-30 |
| 234 | A Phase I Clinical Trial Testing The Accuracy of A Continuous Ketone Monitoring (CKM) System in Individuals With Type 1 Diabetes on Insulin Pump Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this 14-day randomized pilot trial is to assess the accuracy of a continuous ketone monitoring (CKM) system when compared to standard point-of-care capillary ketone monitors in individuals with type 1 diabetes on insulin pump therapy. The main question it aims to answer is: – … |
MELISSA-ROSINA PASQUA; | 2024-04-30 |
| 235 | A Randomized, Open-label, Parallel, Treat to Target Study Comparing The Efficacy and Safety of HR17031 With Insulin Glargine in Chines Subjects With Type 2 Diabetes Inadequately Controlled With Metformin in Combination With or Without Another Oral Antidiabetic Drug (OAD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this trial is to confirm the efficacy of HR17031 in controlling glycaemia in Chinese subjects with type 2 diabetes mellitus inadequately controlled on oral antidiabetic agents |
JIANGSU HENGRUI MEDICINE | 2024-04-29 |
| 236 | HM-002-1005 – A Phase 1, Randomized, Double Blind, Placebo Controlled, Single Dose, Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Subjects With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purposes of this study are to: * Evaluate the safety and tolerability of the study drug. * Measure how much of the study drug (HM-002-1005) and its breakdown product get into the bloodstream, … |
ALEXANDER N PREZIOSO; | 2024-04-25 |
| 237 | Psychological Impact of Armed Conflict on Sudanese Diabetic Patients 2024 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study focused on Sudanese people with diabetes who experienced the ongoing war in Sudan. Some people were displaced and others were not. This would had an impact on their mental health. We have investigated this impact and any complications happened to them through Self-Administered questionnaire. |
RAYAN JAMAL YOUSIF KHIDIR; | 2024-04-21 |
| 238 | Assessing The Risk of Chronic Kidney Disease Associated With Metabolic Dysfunction-Associated Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This cross-sectional study of 300 participants investigates the risk of chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes. By evaluating hepatic measurements and metabolic markers, the study aims to identify key risk factors for CKD in this population, contributing valuable insights to inform targeted interventions. |
AHMED MAHMOUD ISMAIL; | 2024-04-20 |
| 239 | A Study to Evaluate The Efficacy and Safety of Once-weekly Insulin Icodec When Switching From Daily Basal Insulins Compared to Once-daily Insulin Glargine U100 in Adults With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares insulin icodec, a new insulin taken once a week, to insulin glargine, an insulin taken once a day. The study medicine will be investigated in participants with type 2 diabetes. Participants will either get insulin icodec or insulin glargine. Which treatment participants get is decided by chance. Insulin icodec is the new medicine being tested, while insulin glargine is already approved and can be prescribed by doctors. Participants will get one injection of insulin icodec once a week, or one injection of insulin glargine once a day, … |
NOVO NORDISK | 2024-04-19 |
| 240 | Prospective Observational Study on The Predictive Value of Cardiac Damage Markers High-sensitivity Cardiac Troponin I (Hs-cTnI), N-terminal Pro-B-natriuretic Peptide (NT-proBNP) and Soluble Suppression of Tumorigenesis-2 (sST2) for Mortality and The Development of Cardiovascular Events in Patients With Type 2 Diabetes (Diabetes-CV) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The Diabetes-CV study is an observational study designed to assess the prognostic value of serum cardiac damage markers high-sensitivity cardiac troponin I (hs-cTnI), N-terminal pro-B-natriuretic peptide (NT-proBNP), and soluble suppression of tumorigenesis-2 (sST2) in predicting mortality, major adverse cardiovascular events, and diabetic complications in patients with type 2 diabetes. |
ELENA TORTATO; | 2024-04-18 |
| 241 | A 26- Week, Multicenter, Open-Label, Single-Arm, Phase 4 Study to Assess The Safety of Lyumjev in Adult Patients With Type 2 Diabetes Mellitus in India PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety of insulin lispro-aabc in adult participants with Type 2 diabetes mellitus in India. The study will last about 33 weeks for each participant, including screening (1 week), Lead-in period (4 weeks), treatment period (26 weeks) and follow up period (2 weeks). |
RAKESH SAHAY; | 2024-04-18 |
| 242 | Photodynamic Therapy As Adjuvant Therapy to Topical Antifungal Treatments for Onychomycosis in Patients With Diabetes. A Prospective Case Series PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There are different therapeutic alternatives for onychomycosis. Systemic therapy is widely used due to its easy accessibility, low cost and high efficacy, but may be associated with systemic adverse events and drug-drug interactions, so its use in patients with diabetes, immunocompromised and frequently take more than five drugs is not recommended even though these individuals are at serious risk of fungal infection. On the other hand, … |
JOSE LUIS LAZARO MARTINEZ; | 2024-04-17 |
| 243 | The Effect of Motivational Interviewing on Well-being, Stress and Difficulties in Individuals With Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted using a randomized controlled trial design to evaluate the effect of online individual motivational interviewing on well-being, stress and difficulties in individuals with diabetes. The study will be conducted between March 2024 and March 2025 with individuals with Type 2 Diabetes who are followed up in Yozgat Bozok University Health Practice and Research Center Internal Medicine Polyclinic. The motivational interview group will receive a motivational interview once a week, lasting a maximum of 40 minutes, consisting of a total of four sessions. Chi-square (X2), t-test, repeated measures analysis of variance, Pearson correlation coefficient, … |
BETÜL BAL; | 2024-04-15 |
| 244 | A Phase 3, Randomized, Multicenter, Double-Blind Study to Investigate The Efficacy and Safety of Retatrutide Once Weekly Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and inadequate glycemic control. The study will last about 11 months and may include up to 11 visits. |
ELI LILLY | 2024-04-10 |
| 245 | Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema 2.4 Mg/2.4 Mg) Once Weekly Versus Semaglutide 2.4 Mg, Cagrilintide 2.4 Mg and Placebo in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look if CagriSema can lower kidney damage in people with chronic kidney disease (CKD), type 2 diabetes (T2D) and overweight or obesity. CagriSema is a new investigational medicine. CagriSema cannot yet be prescribed by doctors. The study will compare CagriSema to the 2 medicines semaglutide and cagrilintide, when they are taken alone. It will also compare CagriSema to a dummy medicine (also called placebo) without any active ingredient. Participant will either get CagriSema, semaglutide, … |
NOVO NORDISK | 2024-04-01 |
| 246 | Proof of Concept Study: Long-term Benefits of A Blend of Nutritional Ingredients for Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective randomized, double-blinded, parallel design study to evaluate the benefits of long-term consumption of two experimental blends of liquid supplements. |
ABBOTT NUTRITION | 2024-04-01 |
| 247 | Glucose Control With A Next Generation Advanced Insulin Delivery System in Adults With Diabetes and Advanced Renal Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this this randomized, clinical trial is to test an automated insulin delivery system (AID) in people with type 1 or type 2 diabetes who are on hemodialysis, peritoneal dialysis, or have advanced chronic kidney disease (CKD). The main objective is: • To test if the AID is superior in regulating blood sugar levels compared with usual care in patients with advanced renal disease Secondary objectives are: • To evaluate the impact on life quality, incidence of low blood sugar, … |
TOBIAS BOMHOLT; | 2024-04-01 |
| 248 | The Effect of Education Program Supported By Cognitive Exercises in Elderly Individuals With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study was planned as a single-center, prospective randomized controlled study. Individuals over 65 years of age with type 2 diabetes without severe cognitive impairment will be included in the study. The primary aim of the study is to improve the cognitive functions of the patients after the interventions. The secondary aim is to strengthen patients’ diabetes self-management and increase their quality of life, especially by improving their glycemic control. For these purposes, in our study, patients will be randomized into three groups: cognitive exercise and diabetes education, … |
HANDE BULUT CANBAZ; | 2024-04-01 |
| 249 | Community-Based Nutrition-Lifestyle Therapy for Pregnant Latina Women With Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Socioeconomically disadvantaged (SED) pregnant Latina women are disproportionately burdened by type 2 diabetes (T2D). Although lifestyle interventions can help to improve diabetes control, there are barriers to SED, Spanish-speaking pregnant people participating. The purpose of this proposal is to develop and test a culturally tailored, dietary-lifestyle behavioral intervention that supports eating plant-based foods such as fruits, vegetables, nuts and grains instead of processed foods and meat, … |
RACHYL PINES; | 2024-04-01 |
| 250 | Validation of The Accuracy of Continuous Glucose Monitoring Using The Dexcom G7 in Patients with Diabetes in Situations with Circulatory Impairment. A Prospective Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the accuracy of the continuous glucose monitoring (CGM) compared to standard point-of-care (POC) blood glucose measurements in patients with diabetes in patients who during their hospital admission can experience circulatory impairment. The main questions it aims to answer are: • Do CGM measurements have a decreased accuracy compared to standard blood glucose measurements in periods with circulatory impairment? Participants will be asked to wear a blinded CGM device (Dexcom G7, … |
CASPER PEDERSEN; | 2024-04-01 |
| 251 | Improving Recruitment and Retention for Diabetes Self-Management Education and Support By Bridging Clinical-Community Linkages and Supplemental Diabetes Education Technology: A Socio-Ecological Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized clinical trial aims to examine the effectiveness of utilizing CHWs (community health workers) and supplemental diabetes education technology to improve DSMES (diabetes self-management education and support) participation, retention, engagement, and clinical outcomes in adults in Jefferson County, AL living with diabetes. The main questions this study aims to answer are as follows: 1) Is the utilization of a multi-directional recruitment model via partnerships with community health workers and local primary care providers versus traditional recruitment methods (including using flyers, word of mouth, … |
DASHAUNA M BALLARD; | 2024-04-01 |
| 252 | Salivary Signal Molecules Relevant for Neural and Vascular Homeostasis in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Various signal molecules are detected in blood and tissues of patients with T2DM, that are important for the function of neural tissue in diabetic setting. Among them, specifically important are neuroprotective and neurotrophic growth factors such as nerve growth factor (NGF), glial cells – derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Furthermore, several other signal molecules are discovered to affect vascular tissues homeostasis in T2DM, including soluble alpha-klotho (s-Klotho), vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6). Most of these molecules are also detected in saliva in various states and diseases of orofacial system, … |
MARIJA S. MILIC; | 2024-04-01 |
| 253 | Efficacy of FDC Regimen of Dapagliflozin/Metformin Compared to Co-administered Dual Therapy on Glycemic Control, Satisfaction and Adherence in Chinese Patients With T2DM: A 24-Week, Multicentre, Randomized, Parallel, Interventional, Non-inferiority, Open-label Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Study D1690L00149 is a 24-week, multicentre, randomized, parallel, interventional, non-inferiority, open-label study designed to compare the FDC Regimen of Dapagliflozin/Metformin XR with the Dapagliflozin co-administered with Metformin XR in glycemic lowering control, satisfaction and adherence in Chinese patients with T2DM. |
GUANG WANG; | 2024-03-31 |
| 254 | Doxycycline in Combination With Sitagliptin on The Glycemic and Cardiac Indices in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia, weight loss, and cardio-metabolic complications. T2DM develops due to the progression of insulin resistance (IR), impairment of insulin insensitivity, and failure of the pancreatic β-cells to release sufficient amount of insulin in response to glucose burden |
MOSTAFA BAHAA; | 2024-03-30 |
| 255 | Evaluation of The Effect of Stretching Exercises Applied to Diabetes Patients on Physiological Parameters and Compliance to Treatment: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research will be carried out as a pretest-posttest randomized controlled study to determine the effect of stretching exercises performed 2 days a week for 12 weeks for one hour each session on physiological parameters and treatment compliance in individuals with diabetes. |
GÜRCAN SOLMAZ; | 2024-03-30 |
| 256 | Evaluating The Feasibility of Type 1 Diabetes Education and Support (T1DES) Intervention to Improve Diabetes Distress Among Black Young Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes distress has been identified as one of the largest contributors to the racial disparity in glycemic control that disproportionately burdens Black patients ages 18-30 years with type 1 diabetes (T1D). In order to combat this issue, this study assesses the feasibility of the culturally tailored intervention T1DES and evaluates the effect of the T1DES intervention on diabetes outcomes in a pilot randomized clinical trial among Black young adults with T1D. |
TEANIESE L DAVIS; | 2024-03-25 |
| 257 | Effects of Eccentric Training on Glycemic Control and Quality of Life in Patients With Type II Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes is defined by the level of hyperglycemia its a metabolic chronic disorder that furthur lead to life threatning medical conditions however, the prevalence of diabetes is rapidly increasing day by day in both developed and developing countries making it global pandemic and type II is more prevalent. Life dependency is increased due to long term effects of diabetes in specifically older individuals. Physical activity and exercise improves glucose tolerance and also reduces other life threatening diabetic complications, improving the quality of life in diabetic population. |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-03-20 |
| 258 | Investigation of The Safety and Efficacy of Once Weekly NNC0519-0130 in Participants With Type 2 Diabetes – A Dose Finding Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at how well a new medicine called NNC0519-0130 helps people with type 2 diabetes lower their blood sugar and body weight. The study will test up to 7 different doses of NNC0519-0130. Which treatment participant will get is decided by chance. Participants will take 1-3 injections once a week. The study medicine will be injected under skin with a thin needle in the stomach, thigh, or upper arm. The study will last for about 40 weeks. |
NOVO NORDISK | 2024-03-18 |
| 259 | A Multicenter, Prospective, Non-interventional Observation Study to Evaluate The Safety and Effectiveness of OAD Triple Therapy in Korean Type 2 Diabetic Mellitus Patients PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: A multicenter, prospective, non-interventional observation study to evaluate the safety and effectiveness of OAD triple therapy in Korean Type 2 diabetic mellitus patients. |
CHONG KUN DANG PHARMACEUTICAL | 2024-03-16 |
| 260 | A Phase 3, Randomized, Multicenter, Double-Blind Study to Investigate The Efficacy and Safety of Retatrutide Once Weekly Compared With Placebo in Adult Participants With Type 2 Diabetes, Moderate or Severe Renal Impairment With Inadequate Glycemic Control on Basal Insulin With or Without Metformin And/or SGLT2 Inhibitor PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and renal impairment, with inadequate glycemic control on basal insulin alone or a combination of basal insulin with or without metformin and/or sodium-glucose cotransporter-2 (SGLT2) inhibitor. The study will last about 14 months and may include up to 22 visits. |
MICHAEL QUADRINI; | 2024-03-15 |
| 261 | Hybrid Closed Loop Insulin Pump and Bariatric Surgery in Patients With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bariatric surgery is increasingly performed on patients with type 1 diabetes. It exposes these patients to an increased risk of hypoglycemia, including severe hypoglycemia, and of severe episodes of hyperglycemia, beyond the perioperative period. The long-term efficacy and safety of hybrid closed-loop insulin pump in these patients has not yet been published. |
GEOFFREY BOULATE; | 2024-03-15 |
| 262 | The Effect of Healthy Nutrition and Functional Foods Education Based on The Health Promotion Model for Individuals With Type 2 Diabetes on Healthy Lifestyle Behaviors and Self-Efficacy in Diabetes: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-communicable diseases (NCDs) are defined by the World Health Organization (WHO) as slowly progressing and long-lasting diseases, health problems that require continuous care due to the combination of genetic, physiological, environmental, and behavioral factors. (WHO 2023). One of these health issues, Diabetes Mellitus (DM), is one of the chronic and universal health problems affecting many people worldwide (Ministry of Health 2021). When diabetes is not controlled, many acute or chronic complications arise that significantly affect both the individual and society (Üstündağ and Dayapoğlu, 2021). As a result of the complications caused by diabetes, … |
OZNUR GUNGOR; | 2024-03-15 |
| 263 | Access to Clinical Care, Education and Screening for Underserved Children and Adults With Type 1 Diabetes (ACCESS-T1D) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to identify people with T1D or celiac disease (CD) early in the course of their disease and to improve the methods of screening for these diseases. |
ANNA CASU; | 2024-03-11 |
| 264 | Evaluating The Efficacy and Quality of Life Impact of Transitioning to Advanced Hybrid Closed-Loop Insulin Pump Therapy in Romanian Children With Type 1 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study aims to demonstrate the potential benefits of transitioning T1DM children from predictive low glucose suspend insulin pump therapy to advanced hybrid closed-loop insulin pump therapy in Romania. Primary Outcome: Variations in HbA1c between baseline visit (V1 – 740G) and assessment visit following three months of 780G insulin pump therapy (V2 – 780G). Secondary Outcomes: changes in insulin requirements, time in range (TIR) levels, time below range (TBR), coefficient of variation (CV), frequency of severe hypoglycemic and hyperglycemic events requiring hospitalization, and PedsQL SF15 questionnaire scores. |
IOACARA SORIN; | 2024-03-11 |
| 265 | Turning The Tides: Achieving Rapid, Safe and Sustained Glucose Control in Adolescents With Suboptimally Controlled Type 1 Diabetes Using Advanced Hybrid Closed Loop Systems PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The rational of this study is to assess if AHCL systems are able to achieve a better metabolic control (better glucometric data) after 2 weeks, 1 months. 6 months and 1 year after the start, in adolescents in not good glycaemic control. |
GIULIO FRONTINO; | 2024-03-11 |
| 266 | Open, Single Arm, Prospective, Multicenter Study of An Investigational Extended Wear Insulin Infusion Set During Home Use in People With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to collect clinical data to support a 7-day wear of the Extended Wear Infusion Set (EWIS). Participants will be asked to: 1. Wear the EWIS for up to 7 consecutive days for 12 consecutive wear periods 2. Perform blood glucose and ketone measurements if continuous glucose meter is ≥250mg/dL for one hour |
DAVID AHN; | 2024-03-07 |
| 267 | Increasing Uptake of EHR-enabled Population Health Outreach Strategies to Improve Diabetes Screening PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The study team’s central hypothesis is that the Parkland Diabetes Detection Program (PDDP) screening invitations targeted by race/ethnicity with culturally concordant messaging and tailored by glycemic risk (known PDM vs. unknown glycemic state) plus phone-based navigation of non-responders will be more effective at closing screening gaps than PDDP generic screening invitations and usual care, opportunistic screening alone. |
MICHAEL EDWARD BOWEN; | 2024-03-05 |
| 268 | Randomized Cross-over Designed Study of The Physiological Impact of Alpha MSH on Glycemic Response to An Oral Glucose Tolerance Test in Patients With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Alpha-melanocyte stimulatory hormone (α-MSH) is a melanocyte-stimulating hormone produced by the hypothalamus and released from the pituitary gland. It acts as an agonist to the melanocortin 5 receptor (MC5R) in human skeletal muscle, playing a role in glucose uptake and disposal. This study aims to investigate whether α-MSH can enhance glucose tolerance in patients with Type 2 Diabetes Mellitus (T2DM). |
EBAA AL OZAIRI; | 2024-03-04 |
| 269 | Hypoglycemia Biomarkers to Predict Timing of A Hypoglycemic Event PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to obtain a panel of biomarkers from hypoglycemic diabetic patients with either type 1 or type 2 diabetics and from control patients with type 1 or type 2 diabetes who didn’t have hypoglycemia in the last 72 hours. |
NAJI ALAMUDDIN; | 2024-03-03 |
| 270 | Impact of The Menstrual Cycle on The Control of Type 1 Diabetes in Reproductive Aged Women Using An Advanced Closed Loop System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this observational study is to assess the effectiveness of automatic insulin infusion in responding to changes in insulin sensitivity throughout various phases of the menstrual cycle in a cohort of reproductive-aged women with type 1 diabetes, using an advanced closed-loop system. By gaining insights into both the limitations and effectiveness of this adaptation, we aim to inform the enhancement of control algorithms and learning strategies within closed-loop systems. This research is especially vital for addressing the distinct challenges that women commonly encounter in maintaining glycemic control. |
LÍA NATTERO; | 2024-03-03 |
| 271 | Clinical Spectrum of Infants of Diabetic Mothers , in Neonatal Intensive Care Unit of Assiut University Children’s Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Determine spectrum of clinical presentations and complications associated with maternal diabetes mellitus in their newborns attending and admitted to Neonatal Intensive Care Unit of Assiut University Children’s Hospital. |
DINA NASSER MAHROUS DANIAL; | 2024-03-01 |
| 272 | Predictors of Chronic Kidney Disease Among Type 2 Diabetic Patients in Assiut University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Predictors of Chronic Kidney Disease among Type 2 Diabetic Patients in Assiut University Hospitals. |
MUHAMMED ALI ABOALSAUD; | 2024-03-01 |
| 273 | Efficacy and Safety of Incorporating Sodium-glucose Cotransporter-2 Inhibitors to Regimens of Diabetes Patients Already Receiving Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To detect the efficacy of SGLT2i in improving the metabolic parameters in patients with type 2 diabetes. – To detect the side-effects of SGLT2i |
CAROLINE REFAAT LABIB; | 2024-03-01 |
| 274 | A Pivotal Multi-centre, Open-label, Two-part Clinical Investigation Confirming The Safety and Accuracy of The Glyconics-DS in Assessment of Glycated Nail Keratin in Individuals With Unknown Diabetes Status and Performance Evaluation of The Glyconics SW Package Delivering The Dichotomised Results PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main clinical study objective is to confirm the accuracy of the Glyconics-DS spectrometer when used in its intended medical purpose population, i.e., in individuals with unknown diabetes risk. Additionally, … |
DIDAC MAURICIO; | 2024-03-01 |
| 275 | Culturally Tailoring The Delivery of An Evidence-Based Diabetes Self-Management Program for Black Adults to Enhance Its Reach, Adoption, Implementation, and Effectiveness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to conduct the Healthy Living with Diabetes (HLWD) program among Black individuals in a culturally appropriate manner. This study will involve 24-30 participants in total. Participants can expect to be on study for approximately 6 months. |
OLAYINKA SHIYANBOLA; | 2024-03-01 |
| 276 | Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn about how medication that is used to help treat low blood pressure during a Cesarean delivery (CD) can cause changes to the uterine muscle tissue and its ability to contract, in patients with Type II and gestational diabetes. Spinal anesthesia administered during elective CD has been known to cause hypotension (low blood pressure) as a side effect during the procedure, … |
MRINALINI BALKI; | 2024-03-01 |
| 277 | Relation of Helicobacter Pylori Infection in Patients With Impaired Glucose Tolerance and Their Lipid Profile in Upper Egypt PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to : find the relation between H.pylori infection and pre-diabetic patients with lipid profile . Specifically, the study aims to: 1. affect of H.pylori infection in pre-diabetic patients 2. realation between Pre-diabetic patient and lipid profile 3. Risk factor of H.pylori infection in pre-diabetic patients D)HbA1C test measures your average blood sugar level over the past 2 or 3 months. e)Fasting Blood Sugar Test. f) the IgG antibody of h.pylori. |
KHALED MAHMMOUD IBRAHIM; | 2024-03-01 |
| 278 | The Intelligent Diabetes TelemonitoRing Using Decision Support to Treat Patients on Insulin Trial: Study Protocol for A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The trial is an open-label, randomized controlled trial. Patients with T2D on insulin therapy will be randomized to an intelligent telemonitoring group (intervention), a telemonitoring group (control), and a usual care group (control). Both the intelligent telemonitoring group and the telemonitoring group will use various devices at home. Hospital staff will monitor their data for six months. In the intelligent telemonitoring group, hospital staff and participants will be supported by decision-support algorithms in the management of insulin treatment. |
PETER VESTERGAARD; | 2024-03-01 |
| 279 | The Effect of Non Surgical Periodontal Therapy on The Ratio of TNF-α to IL-10 in Periodontitis Patients With Diabetics Mellites PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Periodontitis is a chronic inflammatory disease affecting the periodontium, characterized by irreversible damage to the gingiva, periodontal ligament, and alveolar bone. It is prevalent among adults, significantly impacting oral health and quality of life. This study investigates the effect of non-surgical periodontal therapy (NSPT) on the levels of Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-10 (IL-10) in periodontitis patients with and without diabetes mellitus type II. |
MAHETAB MOHAMED; | 2024-03-01 |
| 280 | The Detection of Chronic Obstructive Pulmonary Disease in Patients With Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Chronic obstructive pulmonary disease (COPD) is an ongoing lung condition caused by damage to the lungs. The damage results in swelling and irritation, also called inflammation, inside the airways that limit airflow into and out of the lungs. Diabetes can worsen the progression and prognosis of COPD. |
MUHAMMAD NAVEED BABUR; | 2024-02-28 |
| 281 | A Parallel-group, Randomized, Prospective, Interventional, Double-blind, Multicenter Global Phase 3 Study to Investigate The Efficacy and Safety of Finerenone Versus Placebo, in Addition to Standard of Care, in Participants With Chronic Kidney Disease and Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Researchers are looking for a better way to treat people with chronic kidney disease (CKD), a progressive decrease in the kidneys’ ability to work properly, and type 1 diabetes. In people with type 1 diabetes, the body does not make enough of a hormone called insulin, resulting in high blood sugar levels that can cause damage to the kidneys. CKD often occurs together with or as a consequence of type 1 diabetes. The study treatment finerenone works by blocking certain proteins, … |
BAYER | 2024-02-26 |
| 282 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 2 Study Evaluating The Safety, Tolerability, and Efficacy of RAY1225 in Participants With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to learn more about the Tolerability of RAY1225 in participants with type 2 diabetes mellitus. The study will also explore the efficacy of RAY1225. The study will last about six months for each participant. |
GUANGDONG RAYNOVENT BIOTECH | 2024-02-26 |
| 283 | Pharmacodynamic Properties of Insulin Icodec During Exercise and Prolonged Fasting in Participants With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will investigate the safety of once weekly insulin icodec subcutaenously (s.c.) during and after exercise and prolonged fasting in patients with type 2 diabetes (T2D). Participants will first receive insulin decludec (Tresiba®, … |
NOVO NORDISK | 2024-02-26 |
| 284 | A Feasibility Study of A Digital Mental Health Intervention (Wysa in Hindi) in Improving Mental Health Distress in Adolescents and Young Adults With Type 1 Diabetes in Low Resource Settings PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The principal objective of this study is to investigate the feasibility of including a digital mental health intervention (Wysa in Hindi) within pre-existing usual care to support adolescents and young adults with Type 1 Diabetes (T1D) who have mild and above mental health distress (operationalized as Patient Health Questionnaire-9: 5-14 scores; … |
TEJASWI SHETTY; | 2024-02-23 |
| 285 | An Exploratory Study to Assess The Accuracy in The Normo- to Hyperglycemic Range of The Spiden Non-invasive Continuous Glucose Monitor Clinical Demo (niCGM), in Trial Participants With Type 1 or Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-centre, multiple sequential-cohort, open study. |
MARC STOFFEL; | 2024-02-23 |
| 286 | A Phase 3, Randomized, Multicenter, Open-label Study to Investigate The Efficacy and Safety of Retatrutide Once Weekly Compared With Semaglutide Once Weekly in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose cotransporter-2 inhibitor (SGLT2i). The study will last about 26 months and may include up to 24 visits. |
ELI LILLY | 2024-02-21 |
| 287 | Correlation Analysis of Type II Diabetes Mellitus on Short-term and Long-term Outcomes of Patients With Esophageal Squamous Cell Cancer Undergoing Minimally Invasive Esophagectomy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To date, there is controversy as to whether type II diabetes mellitus is associated with adverse short- and long-term outcomes in patients with esophageal squamous cell carcinoma undergoing minimally invasive esophagectomy. At the same time, to the best of our knowledge, the impact of metformin use and glycemic control on short- and long-term outcomes in this patient population is also controversial. Therefore, … |
WEI GUO; | 2024-02-20 |
| 288 | A Phase 1, Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled Study to Assess The Safety, Tolerability, and Pharmacokinetics of Multiple Escalating Oral Doses of PF-06954522 in Adult Participants With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple escalating oral doses of PF-06954522 in adult participants with inadequately controlled type 2 diabetes mellitus (T2DM) on metformin (Part A) and optionally in non-diabetic participants with obesity (Part B). |
PFIZER | 2024-02-20 |
| 289 | A 40-week Study Comparing The Efficacy and Safety of Once Weekly IcoSema and Daily Insulin Glargine 100 Units/mL in Participants With Type 2 Diabetes Inadequately Controlled on Oral Anti Diabetic Drugs COMBINE 4 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will compare the new medicine IcoSema, which is a combination of insulin icodec and semaglutide, taken once a week, to insulin glargine (mentioned as insulin glargine in this form) taken daily in people with type 2 diabetes. The study will look at how well IcoSema controls blood sugar levels as compared to insulin glargine in people with type 2 diabetes who do not have their blood sugar properly controlled with other oral diabetes medicines. Participant will either get IcoSema or insulin glargine. Which treatment participants get is decided by chance. IcoSema is a new medicine that doctors cannot prescribe. Doctors can already prescribe insulin glargine in many countries. The study will last for about 11 months (47 weeks). |
NOVO NORDISK | 2024-02-15 |
| 290 | Accuracy and Perspectives of CGM Use During Hospitalization in Youth PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is assessing the accuracy and usability of a continuous glucose monitor during hospital admissions in youth with hyperglycemia due to diabetes or other underlying conditions that requires frequent glucose monitoring. In addition, pediatric patient/family and nursing staff feedback on their perspectives and usability of the system in the hospital will be assessed through surveys. |
UNIVERSITY OF COLORADO DENVER | 2024-02-15 |
| 291 | Research on The Effectiveness of Using Decision Cycle for Person-Centered Glycemic Management on Self-Care Behaviors in Outpatients With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Decision cycle for person-centered glycemic management is a new diabetes decision making .It is defined as a purposefully designed holistic care intervention .The goal is to improve the self-care behavior of patients with type 2 diabetes, thereby improving glycated hemoglobin levels and delaying the occurrence of complications. |
KANG-CHIH FAN; | 2024-02-14 |
| 292 | Comparison of Passive Stretching Versus Electrical Stimulation on Glucose Level, Functional Mobility and Perceived-fatigue in Elderly With Type II Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sixty elderly diabetics (type II) their age ranged from 60-75 years had been divided into two equal groups; group (A) treated by 40-minute passive stretching exercises, while the group (B) treated by 30 minutes electrical stimulation three times per week for 12 weeks. Blood glucose level,Time up and go test (TUG) and Fatigue severity scale were done before and after 12 weeks of the study.Conclusion: Both electrical stimulation and passive stretching are effective to lowering blood glucose level and can be proposed for those people restricted to perform exercise. |
MONA MOHAMED ABDELKHALEK; | 2024-02-10 |
| 293 | Vitamin B12, Vitamin D and Iron Supplementation for Improvement of Nerve Conduction Velocities in Children and Youth With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 1 diabetes can complicate to peripheral neuropathy due to preferential involvement of small unmyelinated nerve fibers (pain and temperature sensation) followed by myelinated nerve fibers (vibration and proprioception). The SEARCH for diabetes in youth study found diabetic neuropathy in 7% of T1D youth. The clinical form of peripheral neuropathy is rare in childhood and pathophysiological changes begin during childhood and accelerate in puberty. Adolescents with these changes can be picked up more reliably by electrophysiological studies than by clinical examination. Nerve conduction studies are the gold standard diagnostic tests for detection of peripheral neuropathy. Role of vitamin B12 in nerve regeneration is well known while causal association of vitamin D deficiency in type 1 diabetes and its role in axonal degeneration is also reported. The previous ongoing studies from authors’ group have shown relationship between poor oral iron intake and subclinical neuropathy in children with type 1 diabetes (manuscript in submission). The present randomised clinical trial is aimed at assessing vitamin B12, vitamin D and iron supplementation for improvement of nerve conduction velocities in children and youth with type 1 diabetes. |
ANURADHA KHADILKAR; | 2024-02-08 |
| 294 | Closed-loop Insulin Delivery Systems (Artificial Pancreas) in Patients With Pancreatitis or Pancreatectomy-induced Diabetes: An Observational Case Series PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the metabolic and the safety outcomes in people living with pancreatic diabetes (pancreatitis or pancreatectomy-induced diabetes) and using a closed-loop insulin delivery systems (artificial pancreas). |
ALFRED PENFORNIS; | 2024-02-06 |
| 295 | Type 2 Diabetes Mellitus and Cancer: Phenotyping of Patients at A Third-level Diabetes Centre PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Recent research has highlighted the significant relationship between type 2 diabetes mellitus and cancer, both prevalent and impactful on global health. The intrinsic correlation arises from shared metabolic processes, particularly a systemic and chronic inflammatory state driven by factors like obesity, dyslipidemia, and hyperglycemia. This leads to the creation of a self-sustaining microenvironment known as meta-inflammation, promoting cancer development through DNA damage, oxidative stress, and the influence of hormones like leptin. The hyperglycemic environment in diabetes contributes to cancer development, … |
FLAVIA PRODAM; | 2024-02-04 |
| 296 | A Multiphase Optimization Strategy to Enhance Diabetes Management Interventions for Black and Hispanic Patients With Uncontrolled Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to learn about the best way to enhance pharmacy-related care for diabetes self-management. This research is being done because we want to improve use of medicines and diabetes management among Black and Hispanic adults with type 2 diabetes and find out which of type of support may improve diabetes self-management for Black and Hispanic adults. Participants will be assigned to one of 4 groups, and will either: * receive care as usual; or, * receive added medicine management support from a pharmacist; or, … |
MICHELLE CHUI; | 2024-02-03 |
| 297 | Personalized Management of Type 2 Diabetes Using AI-Guided (GenAIS TM) Dietary Supplementation: A Randomized Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial investigates the effectiveness of AI-guided dietary supplement prescriptions compared to standard physician-guided prescriptions in managing Type 2 diabetes (T2D). The study includes 160 participants with T2D, aged 40-75, who will be randomly assigned to either the control group (standard physician-guided prescriptions) or the AI-guided group (prescriptions determined by GenAIS, an AI system by Triangel Scientific). The primary objective is to compare the reduction in HbA1c levels between the two groups over 6 months. Secondary outcomes include changes in fasting glucose, lipid profiles, body weight, BMI, hsCRP levels, … |
S LAB SOLOWAYS | 2024-02-02 |
| 298 | Clinical Diagnosis of Diabetes Using Surface-enhanced Raman Spectroscopy Liquid Biopsy and Machine Learning PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to adapt the gold nanoparticle-based surface-enhanced Raman spectroscopy (SERS) technology to clinical application. In this exploratory study, a measurement protocol will be established to investigate whether SERS (combined with multivariate data analysis or machine learning algorithms) allows the diagnosis of patients with diabetes. |
ROGER MOLTO PALLARES; | 2024-02-02 |
| 299 | Effect Of Health Extension Worker-Led Based Interventions on Improving Self-Management Behavior Among Diabetic Patients in Ethiopia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite the existence of lifestyle interventions designed to encourage self-management behaviors, the difficulty of adhering to recommended practices remains a widespread issue globally, including in Ethiopia. Traditional approaches to care have demonstrated limited effectiveness in promoting self-management behavior. As a potential solution, a Health Extension Worker-Led club-based intervention has been implemented. Therefore, the aim of this study is to assess the impact of the Health Extension Worker-Led club-based intervention on improving self-management behaviors and glycemic control. The study will utilize a parallel-group, … |
AKINE ESHETE; | 2024-02-01 |
| 300 | The Prevalence of Non-Alcoholic Fatty Liver Disease in Type 1 Diabetes Mellitus Patients Followed at Ziekenhuis Oost-Limburg, Genk, Belgium PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the prevalence of NAFLD in T1DM patients. |
ZIEKENHUIS OOST LIMBURG | 2024-02-01 |
| 301 | Meals 4 Moms: Development and Feasibility of A Multilevel Community-based Lifestyle Intervention for Gestational Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the project is to conduct a pilot feasibility randomized trial comparing a community-based lifestyle intervention called Meals for Moms (M4M) versus the usual care for pregnant persons diagnosed with gestational diabetes (GDM). Participants will be randomly placed into the usual care (UC) comparison group or the M4M healthy living program, which includes continued GDM education, physical activity level monitoring, and delivery of medically-tailored GDM meals. The trial will assess if M4M is feasible for the management of gestational diabetes in pregnant patients. |
ANDREA SHIELDS; | 2024-02-01 |
| 302 | Evaluating The Feasibility of A Future Trial-based Economic Evaluation of A Multistage Shared Decision-making Program for The Treatment of Type 2 Diabetes Mellitus: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 2 diabetes mellitus is a highly prevalent disease, affecting over a million Dutch citizens, leading to severe micro- and macrovascular complications, reduced quality of life, and high healthcare costs. Clinical guidelines recommend a person-centered approach to improve (health)outcomes. However, with rapidly increasing treatment options, both in terms of medication and lifestyle interventions, shared decision making (SDM) is challenging in practice. Therefore, researchers have developed a multistage SDM program consisting of an online patient decision aid for type 2 diabetes mellitus, training for healthcare professionals in SDM, … |
ARIANNE ELISSEN; | 2024-02-01 |
| 303 | The Effect of Effort During A Resistance Exercise Session on Glycemic Control in Individuals With Prediabetes or Type 2 Diabetes Mellitus: A Randomized-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the degree of effort during a resistance exercise session on blood glucose levels in individuals with prediabetes or type 2 diabetes mellitus. The main questions it aims to answer are: – Do individuals with prediabetes or type 2 diabetes mellitus need to perform resistance exercise with a high degree of effort for their blood glucose to improve? – How do they feel (their enjoyment, discomfort) after the sessions with different degrees of effort? Participants will perform 3 situations separated by at least 4 days, … |
FLAVIO DE CASTRO MAGALHAES; | 2024-02-01 |
| 304 | Prevalence of The Appearance of Diabetic Ulcers, After The Manufacture and Adaptation of Personalized Insoles, With Monitoring of Temperature and Plantar Pressure in Diabetic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes is a serious and chronic disease that affects more than 347 million people in the world. It is the leading cause of death by age and its prevalence is increasing annually throughout the world. Diabetes is a disorder that manifests itself with elevated blood glucose levels that may be the resultof a deficiency in insulin secretion or action, or a combination of both problems. The Diabetic foot includes a number of syndromes in which the interaction of the loss of protective sensation by the presence of sensory neuropathy, the change in pressure points due to motor neuropathy, … |
ESTHER SOLER; | 2024-02-01 |
| 305 | Real-world Use of Hybrid Closed Loop in Adolescents and Young Adults 15-25 Years of Age With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the effect of hybrid closed loop on glycemic outcomes in young patients aged between 15 and 25 years old with type 1 diabetes, whatever is their initial metabolic control. |
JULIETTE EROUKHMANOFF; | 2024-02-01 |
| 306 | The Effect on HbA1c of The Initiation of Continuous Glucose Monitoring in Adults With Type 2 Diabetes Treated With Basal Insulin in Finland PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to determine the impact of starting the use of the FreeStyle Libre 2 glucose monitoring system, over a three month period, on HbA1c in adults with type 2 diabetes treated with a basal insulin regimen. |
HENRI HONKA; | 2024-02-01 |
| 307 | Whole Body Vibration Exercise Intervention for Glycemic Control in Type 2 Diabetes Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes generates a great impact on society, as well as a concern for health professionals due to its high and increasing prevalence; there are more and more studies that demonstrate the effectiveness of vibration platforms and their benefits at a physiological level. The objective is to analyze the decrease in glycosylated hemoglobin and glycemia levels after the use of whole body vibration platforms and the possible inclusion of this therapeutic option within the usual treatments.The sample will be composed of people diagnosed with Type 2 Diabetes Mellitus in the Plasencia area (Cáceres, … |
VICENTE RODRÍGUEZ PÉREZ; | 2024-02-01 |
| 308 | Effect of Heatwaves on Glycemic Control in Adult Patients With Type 1 Diabetes Mellitus Treated With Advanced Hybrid Closed Loop Systems PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To analyze the effect of heatwaves on interstitial glucose in adult patients with type 1 diabetes mellitus treated with artificial pancreas |
PALOMA GONZALEZ; | 2024-01-22 |
| 309 | Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes: A Cross-sectional Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 2 diabetes and metabolic (dysfunction)-associated fatty liver disease (MAFLD) often exist together. The prevalence of MAFLD is about 15-30% in healthy people and around 60-70% in people with type 2 diabetes. Moreover, type 2 diabetes accelerates the progression of liver disease in MAFLD. MAFLD is a spectrum of liver conditions, ranging from simple fatty liver (low risk for progression), progressing to steatohepatitis (MASH) with no or mild fibrosis, advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma. Although diabetes is the strongest predictor of advanced fibrosis in MAFLD, however, … |
MOHAMMAD SHAFI KUCHAY; | 2024-01-20 |
| 310 | Concordance of Hypoglycemia Measurement in People With Type 1 Diabetes, With Simultaneous Use of Two Devices for Continuous Glucose Measurement: Abbott Freestyle Libre 2 and Dexcom G7 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to compare two frequently used sensors for continuous glucose monitoring (CGM); Freestyle Libre and Dexcom G 7. More precisely, the investigators want to investigate if there is any difference in the hypoglycemic range for these two devices. |
KLAVS WÜRGLER HANSEN; | 2024-01-19 |
| 311 | A Multicenter, Randomized, Open-label, Controlled Study on Evaluating The Efficacy and Safety of Switching From Daily DPP-4 Inhibitors to HSK7653 Tablets in Patients With Type 2 Diabetes Mellitus in China PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the effectiveness of HSK7653 tablets following the substitution of daily DPP-4 inhibitor (DPP-4i) over a 24-week treatment period. |
HAISCO PHARMACEUTICAL GROUP | 2024-01-15 |
| 312 | The Effect of Education and Motivational Interviews Conducted Through Tele-Nursing on Diabetes Management in Adolescents With Type 1 Diabetes: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The deterioration of glycemic control in adolescents with Type 1 diabetes (T1DM) is a genuine cause for concern. Possible reasons for worsening glycemic control in youth include lack of monitoring, inadequate self-care, psychosocial factors, lack of family support and parental supervision, non-adherence to treatment, pubertal increases in insulin resistance, and insufficient transition from pediatric to adult care. In adolescents with established T1DM who transition to adult-focused care, … |
PINAR DURU; | 2024-01-15 |
| 313 | A Phase 3, Randomized, Open-Label Study to Investigate The Efficacy and Safety of Once Daily Oral Orforglipron Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin (ACHIEVE-2) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the safety and efficacy of orforglipron compared with dapagliflozin in improving blood sugar control in participants with type 2 diabetes (T2D) with inadequate glycemic control using metformin. The study will last approximately 46 weeks. |
ELI LILLY | 2024-01-10 |
| 314 | Improving Appetite Self-Regulation in African American Adults With Type 2 Diabetes: A Digital Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this 6-month randomized clinical trial is to examine the feasibility of recruitment, attendance, retention, program adherence, and satisfaction of a digital application designed, Centering Appetite to improve glucose scores (HbA1c) and binge eating in African American adults with type 2 diabetes. Intervention participants will receive type 2 diabetes education and web-based lessons on appetite self-regulation. Participants will also receive a Fitbit to monitor daily physical activity. The investigators will follow up with participants at six months. |
RACHEL GOODE; | 2024-01-09 |
| 315 | Intervention for Children With Type 1 Diabetes Targeting Gut Microbes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to evaluate the effect of nutritional intervention program based on dietary products in the clinical treatment of newly diagnosed children with type 1 diabetes. The main question aims to answer is: whether high fiber diet can protect beta-cell function in children with newly onset type 1 diabetes. Participants will take 12 weeks of high fiber diet intervention and beta-cell function and gut microbiota structure will be analyzed. |
FEIHONG LUO; | 2024-01-08 |
| 316 | Glucose Metrics Using Freestyle Libre 3 Real-Time Continuous Glucose Monitor (rtCGM) in Patients With Gastroparesis in Type 1 or Type 2 Diabetes: Investigator Initiated Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A pilot study to evaluate and compare glucose metrics using a real-time continuous glucose monitor (FreeStyle Libre 3 sensor) between patients with diabetes and gastroparesis and those with diabetes without gastroparesis. |
SAMITA GARG; | 2024-01-08 |
| 317 | Feasibility of The FreeStyle Libre Continuous Glucose Monitoring System in Youth With Type 2 Diabetes (FREE CGM) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary scientific question of this proposal is to investigate whether youth with T2D will wear and interact with a continuous glucose monitor (CGM) system and whether this will influence behavior and management decisions. There will be 30 participants enrolled in the study. 20 in the treatment arm and 10 in the control. The length of study participation will be 6 months for each participant. |
SHYLAJA SRINIVASAN; | 2024-01-03 |
| 318 | Real-world Study of CHina Ozempic CLinicAl PRactice in Patients With Type 2 Diabetes (SCHOLAR) PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to describe the real-world use and impact of semaglutide once-weekly (OW) among participants with type 2 diabetes mellitus (T2DM) in China. Participants diagnosed with T2DM who initiated semaglutide OW for the first time between 1 Jan 2022 (the date when semaglutide OW was listed in the National Reimbursement Drug List \[NRDL\] in China\] and 28 Feb 2023 (9 months prior to the data extraction cut-off date of 30 Nov 2023) will be included in this study. The study period will be 36 months prior to the first date of participants identification period. |
NOVO NORDISK | 2024-01-02 |
| 319 | Continuous Glucose Monitoring in The Intensive Care Unit: Validation and Implementation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the proposed clinical trial is to study the use of the Dexcom G7 continuous glucose monitor (CGM) within the intensive care unit (ICU) environment. The overall goal is to validate the accuracy and practicality of the Dexcom G7 when used to assess glycemia in critically ill patients. |
JOHN P MORDES; | 2024-01-02 |
| 320 | Cardiovascular Disease, Mortality and Prognostic Factors in Adult-onset Type 1 Diabetes PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: Scarce evidence is available for prognosis in adult-onset type 1 diabetes (T1D). The aim of this study is to investigate the risk of all-cause mortality, cause-specific mortality, and incident CVD in adult-onset T1D, as compared to type 2 diabetes with comparable age at diagnosis and population controls. We will explore potential modifiable factors including lifestyle and clinical characteristics that contribute to T1D prognosis. In addition, we will estimate the life expectancy associated with different age at T1D diagnosis as compared to population controls. This study will be based on people with diabetes recorded in Swedish National Diabetes Registers, … |
SOFIA CARLSSON; | 2024-01-01 |
| 321 | Empowering Patients With Diabetes and Their Family Members: Assessing The Impact of Free Informative Mobile Messages PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Randomized Control Trial aiming at investigating the feasibility and effectiveness of a WhatsApp-based informative intervention on Diabetes Mellitus care in Lebanon and exploring the impact of this intervention on various aspects of Diabetes management and patient outcomes. Family member caregivers will be also included in this interventional study as the research investigators opt to evaluate their DM related knowledge, personal health practices, their involvement in the care of patients with diabetes, and their impact on the patients’ diabetes control before and after the intervention. |
NAJLA EL LAKKIS; | 2024-01-01 |
| 322 | Serum Zinc Levels and Intake in Type 2 Diabetes: Impact on Pathogenesis and Glycemic Control PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: investigation of the impact of zinc level on the development of DM and to elaborate on whether daily consumption of zinc affects the disease’s evolution. |
SARA MOSTAFA ELADAWY; | 2024-01-01 |
| 323 | Effectiveness of A Multidisciplinary Treatment and Structured Education for Type 1 Diabetes Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial compared an structured education programme and multidisciplinary treatment vs an standard treatment in type 1 diabetes patient, the Primary outcome is glycemic control at 6-month follow up and secondary outcome are cardiovascular risk factors control, diabetes related distress, anxiety and depressive symptoms, hypoglycemia awareness. |
DAVID SANCHEZ GARCIA; | 2024-01-01 |
| 324 | A Randomized, Double-blind, Multi-center, Phase 3 Study to Evaluate The Efficacy and Safety of BR1019A and BR1019B Combination Therapy in Patients With Essential Hypertension and Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this clinical study is to Evaluate the Efficacy and Safety of BR1019A and BR1019B combination therapy in Patients with Essential Hypertension and Type 2 Diabetes Mellitus |
BORYUNG PHARMACEUTICAL | 2024-01-01 |
| 325 | Differences In The Severity Of Diabetic Neuropathy Based On Electromyography In Type 2 Diabetes Mellitus Patients With And Without Comorbidities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn the differences severity level of diabetic neuropathy based on electromyelography in type II diabetic patient with and without comorbidities. The main questions of this study: 1. What is the electromyography result in type II diabetic patient who: has no comorbidities, with hypertension, with hypertension and dyslipidemia? 2. Is there any differences in electromyography result in type II diabetic patient who: has no comorbidities, with hypertension, … |
MARIA WIDIASTUTI; | 2024-01-01 |
| 326 | Medical Nutrition Therapy and Diabetes Self-Management Education for People With Disabilities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this project is to develop, and pilot test an accessible and inclusive medical nutrition therapy and diabetes self-management education program for people with Type 2 Diabetes and physical disabilities. |
MOHANRAJ THIRUMALAI; | 2024-01-01 |
| 327 | Benefit of Using Smart Connected Insulin Pens in Dependent Patients With Diabetes Using Continuous Glucose Measurement PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Insulin-treated diabetes in dependent or institutionalized patients is often poorly balanced and continuous glucose measurement is underused. The purpose of this tudy is to know how smart connected insulin pens and continuous glucose measurement can improve insulin therapy practice in dependent and/or institutionalized patients? |
MARIE BOULY; | 2024-01-01 |
| 328 | Development and Evaluation of A Monocular-Camera-Based Mobile Exergame for At-Home Intervention in Individuals at High Risk of Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Exergames have demonstrated potential as effective interventions for promoting physical activity and preventing type 2 diabetes (T2D), particularly among older adults. Kinect-based exergames, in particular, have been associated with improved adherence to exercise regimens and positive health outcomes. However, widespread implementation is limited by the high cost and reduced accessibility of the required hardware, restricting their use in home-based settings. Recent advances in computer vision have enabled the development of exergames using monocular camera systems, … |
JIANAN ZHAO; | 2024-01-01 |
| 329 | An Integrative Online Diabetes Self-Management Education and Support Intervention Featuring Tai Chi Easy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this project is to increase access to diabetes care and education for adults aged 40-64 years old who are diagnosed with Type 2 Diabetes Mellitus and are unable to attend education and support classes due to their work situation. This project will use an established, well-known program for Diabetes Self-Management Education and Support (DSMES) and combine it with Tai Chi Easy (TCE)™ to enhance physical health, psychological health, … |
RUTH TAYLOR-PILIAE; | 2024-01-01 |
| 330 | Empagliflozin Versus Metformin for Glucose Variability and Metabolic Outcomes in Drug-Naïve Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This multicenter, open-label, prospective study randomized 46 drug-naïve adults with T2D (HbA1c 6.5%-10.0%) to receive empagliflozin (10 mg/day) or metformin (1,000 mg/day) for 12 weeks. |
SOO LIM; | 2024-01-01 |
| 331 | Development of Minimally Invasive Methodology for Diabetyping to Personalise Treatment to Realise Remission and Reversal of Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Lifestyle changes in diet and exercise can reverse type 2 diabetes (T2D), also referred to as T2D remission. Although combined lifestyle interventions for T2D remission are promising, not all persons react similarly to such ‘one-size-fits-all’ interventions. Research has shown that as a result of differences in T2D pathophysiology between individuals, different subgroups of T2D can be identified, that differ in which diet is most beneficial in the recovery of pancreatic beta-cell function. TNO and partners work on the development of the Diabetyping Lifestyle Intervention (DLI) for T2D subtypes that tailors the combined lifestyle intervention based on organ dysfunction (liver, … |
TNO | 2024-01-01 |
| 332 | The Effect of Concurrent Aerobic and Resistance Training and Vitamin D Supplementation on Lipid Profile in Patients With Type 2 Diabetes: A Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study protocol is to assess the effect of concurrent aerobic and resistance training and vitamin D supplementation on lipid profile in patients with type 2 diabetes. |
JOEL MONTANE; | 2024-01-01 |
| 333 | Feasibility Trial Using An Insulin Dosing Calculator for Patients With Type 2 Diabetes Mellitus on Hospital Admission PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this feasibility trial is to test whether a novel insulin dosing calculator can improve blood glucose management for patients with type 2 diabetes mellitus on hospital admission. The main questions it aims to answer are: – Whether using this calculator leads to no excessive hypoglycemia? – Whether using this calculator leads to a decrease of hyperglycemia? Participants will receive initial insulin doses by the calculator on hospital admission, … |
HOU-HSIEN CHIANG; | 2024-01-01 |
| 334 | Effectivity of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this study is to assess the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+Dipeptidyl peptidase 4 (DPP-4) inhibitors in poorly controlled type 2 diabetes mellitus (T2DM) patients. The study seeks to evaluate its effect on achieving glycemic goals in this patient population. |
HINA SHARIF; | 2023-12-31 |
| 335 | The Effectiveness of Diabetic Foot Wound Prevention Training Given With Pecha Kucha (20*20) Presentation Technique: A Randomized Controlled PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to evaluate the impact of diabetic foot care training delivered using the Pecha Kucha (20*20) presentation method on the knowledge, self-efficacy, and behavior levels of patients with Type 2 diabetes. Conducted between December 10, 2023, and October 7, 2024, this randomized controlled experimental study included 125 diabetic individuals, with 62 in the experimental group and 63 in the control group. The experimental group received diabetic foot care education using the Pecha Kucha method, while the control group received conventional education. Data were collected using the Patient Assessment Form, Diabetes Foot Knowledge Questionnaire, Diabetic Foot Care Self-Efficacy Scale, … |
BERNA DINCER; | 2023-12-30 |
| 336 | The Effects of Some Antihyperglycemic Drugs on Cognitive Function and Risk of Depression of Diabetic Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, randomized controlled clinical trial with a parallel-group design conducted at Minia University hospital. |
ASMAA ABDELFATTAH ELSAYED; | 2023-12-30 |
| 337 | Evaluation of Dental Ages of Children With Type I Diabetes Using Different Dental Age Estimation Methods-A Retrospective Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to determine the estimated dental age of children with type 1 diabetes by using Cameriere, Willems and Demirjian methods. |
DENIZ SILA ÖZDEMİR CELİK; | 2023-12-25 |
| 338 | PrevaLence of Albuminuria in Patients With CARdiovascular Disease and Type 2 Diabetes Mellitus in China: A National Cross-sectional Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The association between Cardiovascular Disease (CVD) and Chronic Kidney Disease (CKD) is well established. Traditional risk factors for CVD and CKD are similar, with type 2 diabetes mellitus (T2DM) being the most prevalent risk factor. However, CKD is underdiagnosed and undertreated in patients with CVD. Further understanding of the combination of CKD in CVD patients is important to formulate prevention and treatment strategies for CVD patients and high-risk groups, reduce adverse events in CVD patients, and prevent progression of CKD to End Stage Renal Disease (ESRD). |
CHANG SHENG MA; | 2023-12-21 |
| 339 | Validation of Ipswich Touch Test for Diabetic Peripheral Neuropathy Screening in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to assess the accuracy of screening for diabetic peripheral neuropathy by comparing the Ipswich touch test with the 10-g monofilament test in patients diagnosed with type 2 diabetes. The main question it aims to answer is: How does the accuracy of the Ipswich Touch Test for identifying peripheral neuropathy compare to the traditional 10-g monofilament test? Participants underwent both the Ipswich touch test and the 10-g monofilament test. |
PONLAWAT HANCHANA; | 2023-12-21 |
| 340 | The Effect of Diabetes Complications Education Given With Puzzles on The Knowledge Level of Nursing Students PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, it was aimed to investigate the effect of diabetes complications training on endocrine system diseases and nursing care in the Internal Medicine Nursing course on the knowledge level of nursing students. |
BILECIK SEYH EDEBALI UNIVERSITESI | 2023-12-19 |
| 341 | A Phase 2, Multicenter, Randomised, Paralleled, Placebo-controlled (Double-blind) and Active Drug-controlled (Open) Study to Investigate Efficacy and Safety of HEC88473 Injection in Subjects With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, parallel, placebo- and active comparator-controlled phase 2 trial to evaluate the efficacy, safety, pharmacokinetics and immunogenicity in subjects with T2DM. Patients treated with diet and exercise alone, or in combination with stable metformin monotherapy (≥1500 mg/day or maximum tolerated dose ≥1000 mg/ day.), will be enrolled. Approximately 225 participants will be randomized. The study includes four stages: screening period (up to 2 weeks), lead-in period (2 weeks), treatment period (12 weeks) and safety follow-up period (3 weeks after treatment). |
DONGGUAN HEC BIOPHARMACEUTICAL R&D | 2023-12-10 |
| 342 | A Phase 1, Open-Label, Multiple-Dose Study to Investigate Steady-State Pharmacokinetics and Pharmacodynamics During A Euglycemic Clamp of LY3209590 in Participants With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to measure the activity and insulin time action of LY3209590 at steady state in participants with type 2 diabetes mellitus. The total study duration is approximately 182 days. |
OLIVER KLEIN; | 2023-12-09 |
| 343 | A 42-Day Multiple Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-757 And K-833 in Overweight/Obese Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multiple dose study to evaluate the safety, tolerability, PK, and PD of K-757 and K-833 when co-administered in overweight/obese patients with Type 2 diabetes mellitus (T2DM) |
KALLYOPE | 2023-12-07 |
| 344 | Evaluating The Safety and Tolerability of R-5280 in Mitigating Type 1 Diabetes in Newly Diagnosed Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluating the adverse events and tolerance of R-5280 in Mitigating Type 1 Diabetes in Newly Diagnosed Patients |
RISE THERAPEUTICS | 2023-12-05 |
| 345 | Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients With Gestational Diabetes Mellitus in Second Trimester of Pregnancy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To assess the value of serum Pentraxin-3 and high sensitive CRP in females with normal pregnancy and females with gestational diabetes mellitus in second trimester of pregnancy. 2. To study correlations between serum Pentraxin-3 and High sensitive CRP in gestational diabetes. |
MAI MOHAMMED HOSNY; | 2023-12-05 |
| 346 | A Multi-centre, Prospective, Non-interventional, Single-arm Study Investigating Glycaemic Control Associated With The Use of Dose Check App and Insulin Degludec in Patients With Type 2 Diabetes Mellitus in Saudi Arabia Under Real-world Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study looks at how a mobile based app called ‘Dose Check’ used along with Tresiba helps to control blood sugar level in participants with type 2 diabetes mellitus. Participants will get Tresiba as prescribed by the study doctor or participants will continue already prescribed treatment with Tresiba. Participants will also be prescribed to use Dose Check app by the study doctor and will be asked to install the Dose Check app in their mobile phone, which will support participants with the correct dose of Tresiba. This study will last for about 6 to 7 months. |
NOVO NORDISK | 2023-12-03 |
| 347 | The Effect of Mandala Coloring on Perceived Stress and Anxiety Levels in Type-2 Diabetes Patients: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: THIS RESEARCH was planned to examine the effect of mandala painting on the perceived stress and anxiety levels of type-2 diabetic patients. |
GÜLCAN BAHÇECIOĞLU TURAN; | 2023-12-01 |
| 348 | Technological-based Personalized Care Intervention for Supporting Older People With Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this project are (1) to develop a new model of DM management using non-invasive healthcare technology for continuous glucose monitoring; (2) to use health apps to give timely personalized care intervention for enhancing compliance rate of DM self-management; … |
QUEENIE LAW PUI SZE; | 2023-12-01 |
| 349 | An Exploratory 16-Week Pilot Study of The Effect and Safety of A Novel CGM-Based Titration Algorithm for Basal Insulin, With or Without Non-Insulin Antidiabetic Drugs, in Type 2 Diabetes Mellitus Participants Treated With Basal Insulin PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effect of a continuous glucose monitor (CGM) based titration algorithm to standard titration by self-monitoring blood glucose (SMBG) in participants with Type 2 Diabetes already using long acting insulin. The comparison aims to study the difference in glycemic control between the two therapies. Participants will be followed for 18 weeks and will be provided with Degludec insulin, insulin pen, and a CGM (Dexcom G6). |
MARC BRETON; | 2023-11-30 |
| 350 | Monitoring Effect Of Shock Wave On Microcirculation Changes In Type2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to monitor the effect of low intensity extracorporeal shock wave therapy on impaired nitric oxide synthase and microcirculation changes in type 2 diabetes mellitus with peripheral neuropathy. |
IBRAHIM ABUZAID; | 2023-11-28 |
| 351 | A Phase 3, Randomised, Double-blind, Parallel-group, 76-week, Efficacy and Safety Study of BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity and Type 2 Diabetes Mellitus PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults who are at least 18 years old and have a body mass index of 27 kg/m² or more. People can take part if they have type 2 diabetes and if they are currently being treated only with diet and exercise or with specific diabetes medications. Only people who have previously not managed to lose weight by changing their diet can participate. The purpose of this study is to find out whether a medicine called survodutide (BI 456906) helps people living with overweight or obesity who also have diabetes to lose weight. Participants are divided into 3 groups by chance, like drawing names from a hat. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under their skin once a week for about one and a half years. In addition to the study medicine, all participants receive counselling to make changes to their diet and to exercise regularly. Participants are in the study for about 1 year and 7 months. During this time, it is planned that participants visit the study site up to 14 times and receive 6 phone calls by the site staff. The doctors check participants’ health and take note of any unwanted effects. The study staff also regularly measure participants’ body weight. The results are compared between the groups to see whether the treatment works. |
BOEHRINGER INGELHEIM | 2023-11-27 |
| 352 | A Phase II Trial Comparing Efficacy and Safety of GZR101 and Insulin Degludec/Insulin Aspart in Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drug (OAD) Therapy or OAD Therapy in Combination With Insulin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial is conducted in China. The aim of the trial is to compare the efficacy and safety of GZR101 and insulin degludec/insulin aspart in insulin naïve or insulin treated subjects with type 2 diabetes. |
GAN AND LEE PHARMACEUTICALS USA | 2023-11-27 |
| 353 | Older Adults Using Social Support to Improve Self-Care: Adaptation, Implementation, and Feasibility of Peer Support for Older Adults With T2DM in Appalachia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effects of peer coaching models in older adults with unmanaged type two diabetes. The main questions it aims to answer are: * Are peer coaching models effective at promoting Type 2 Diabetes Mellitus self-management? * If effective, which facets of the peer model are most effective? Peer coaches will * Undergo peer coach training. * Reach out to peer participants on a weekly/biweekly time frame to discuss self-management and goal setting. * Retain records of contact, topics discussed, … |
BRITTANY L SMALLS; | 2023-11-20 |
| 354 | Evaluation of The Effect of Finerenone on Renal Function in Patients With Type 2 Diabetes and Chronic Kidney Disease: A Prospective, Single-Arm, Multicenter Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Research Objectives To evaluate the impact of finerenone on renal function, diabetic complications, and safety in patients with Type 2 diabetes and chronic kidney disease. Study Design Type: Prospective, single-arm, multicenter clinical trial. Sample Size: 300 patients. Intervention: Finerenone added to existing treatment regimen (10-20 mg once daily, dose adjusted based on eGFR), for 48 weeks. Data Collection Time Points: Baseline, 4 weeks, 12 weeks, 24 weeks, 36 weeks, and 48 weeks. Primary Endpoint: Change in urine albumin-to-creatinine ratio (UACR). Secondary Endpoints: Changes in eGFR, 24-hour urine protein, serum uric acid, retinopathy markers, pulse wave velocity (PWV), ankle-brachial index (ABI), … |
XIE YING; | 2023-11-17 |
| 355 | Food and Resources Expanded to Support Health and Type 2 Diabetes (FRESH-T2D) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Food insecurity, poor nutrition, and economic disadvantage are critical social determinants of health that contribute to disparities in type 2 diabetes mellitus (T2DM), a serious diet-sensitive chronic disease affecting more than 20% of food insecure adults. There is a demonstrable need for food-focused interventions to address the diet quality of persons with, or at risk of, T2DM. Completion of the pilot study will produce recruitment, retention, adherence, and cost data for a future definitive randomized controlled clinical trial, bringing us closer to the long-term goal of a tested, … |
UNIVERSITY OF ARIZONA | 2023-11-17 |
| 356 | A Single and Multiple-Ascending Dose Phase 1 Study to Assess The Safety, Tolerability, and Pharmacokinetics of LY3938577 in Healthy Participants and Participants With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the safety and tolerability of a single dose of LY3938577 in healthy participants and participants with Type 2 Diabetes Mellitus (T2DM) (Part A) and multiple doses of LY3938577 in participants with T2DM (Part B). The study will last approximately 6 weeks for Part A and approximately 10 weeks for Part B respectively. |
AMINA HAGGAG; | 2023-11-17 |
| 357 | Detection of Pre-Diabetes in Overweight and Obese Children and Adolescents in Assiut Governorate PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Descriptive cross section study To detect prediabetes in overweight and obese children and adolescents in Assiut Governorate and to find out the possible risk factors. |
MAHMOUD BAKR GABER; | 2023-11-15 |
| 358 | The Impact Of Sodium-Glucose Cotransporter 2 Inhibitors on Metabolic Dysfunction -Associated Steatotic Liver Disease In Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study question 1:Could SGLT2-I improve hepatic fibrosis, steatosis, and inflammatory markers in type 2 diabetic patients with Metabolic associated steatotic liver disease Question 2:Which drug of SGLT2-I group is more effective in improving metabolic associated steatotic liver disease in type 2 diabetic patients? |
GEORGE ESMAT ROSHDY; | 2023-11-15 |
| 359 | Evaluation of Tumor Necrosis Factor-alpha Levels and Cardiac Functions in Pediatric Patients Diagnosed With Type 1 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the effect of type 1 diabetes mellitus on cardiac functions and evaluate the correlation of the dysfunction with the tumor necrosis factor-α (TNF-α) an inflammation-related factor. The study population will be the patients with the diagnosis of type 1 diabetes mellitus and the healthy children es the control group. The main question[s] it aims to answer are: – Is diabetes affecting the systolic and diastolic cardiac functions – Is diabetes affecting the left and the right ventricles equally? – Does diabetes status, as assessed by HbA1c, … |
MERVE MAZE AYDEMIR; | 2023-11-15 |
| 360 | Insulin Modelling Based on Plasma Glucose Measures Via A Minimally-Invasive Glucose Sensor PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to evaluate insulin as a potential biomarker for prediabetes in Singapore Chinese subjects. |
CHUN YIP JAMES CHAN; | 2023-11-15 |
| 361 | TeleCare North Diabetes: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This feasibility study will evaluate the feasibility of two telemonitoring designs for non-insulin treated T2D patients with an eye to identify the most suitable telemonitoring intervention for a future large-scale randomized trial. |
PETER VESTERGAARD; | 2023-11-15 |
| 362 | Postprandial Glycaemic Changes When Patients With Type 2 Diabetes Consume The New KDD Products PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: KDD is developing a new line of no-added-sugar products in line with its metabolic reengineering initiative and its metabolic matrix. The recipes fundamentally do not alter total saturated fat or protein levels and mainly offer the benefit of no added sugar and a significant reduction in net carbohydrates as well glycaemic index. |
EBAA AL OZAIRI; | 2023-11-12 |
| 363 | A Phase 3, Randomized, Double-Blind Study to Investigate The Efficacy and Safety of Once Daily Oral Orforglipron Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin And/or SGLT-2 Inhibitor PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine the safety and efficacy of orforglipron. Participants will have Type 2 Diabetes (T2D) and have inadequate glycemic control with insulin glargine with or without metformin and/or SGLT-2 (sodium-glucose cotransporter-2) inhibitor. The study will last about 46 weeks and may include up to 20 visits. |
ELI LILLY | 2023-11-10 |
| 364 | A Pilot Study to Assess The Feasibility of A Novel Non-Invasive Technology to Measure Glucose Dynamics in Adults Living With Type 1 Diabetes Mellitus: A Single-Arm Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this study is to assess the feasibility of the Lab demo 1.0 and associated computational models to detect and track glucose changes noninvasively and transcutaneously in defined and dynamic states of glycemia. |
MARKUS LAIMER; | 2023-11-08 |
| 365 | Patient Preference Study in Type-2 Diabetes Mellitus: Discrete Choice Experiment (DCE) to Support Novo Nordisk’s Long-Acting Insulin PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this research is to assess T2DM patient preferences for a once weekly insulin treatment. The study involves a qualitative interview phase and quantitative survey phase with a Discrete Choice Experiment (DCE). |
NOVO NORDISK | 2023-11-02 |
| 366 | Self-Administered 2-Hour Oral Glucose Tolerance Test: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to evaluate whether self-administered postpartum diabetes screening tests in patients with gestational diabetes improves screening completion rates. The primary question it aims to answer is: 1. Does a self-administered 75-gram oral glucose tolerance test with virtual follow-up visit increase the rate of postpartum diabetes screening within 12 weeks of delivery? |
AMY CROCKETT; | 2023-11-02 |
| 367 | Depression, Anxiety and Stress Disorders Among Diabetic Patients in Assuit University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Assessment the prevalence of psychiatric disorders in diabetic patient in Assuit University Hospital. 2. Determine the associated factors with the psychiatric disorders. |
ALAA ABDELMOATY MOHAMED; | 2023-11-01 |
| 368 | Effect of Short-term Basal Insulin Initiation in Newly Diagnosed Type 2 Diabetes on 1-year Glycemic Control PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, we aim to explore the beneficial effect of early short-term (two weeks), self-titrated, basal-only insulin therapy on the degree of glycemic control over 1-year follow through a prospective cohort. |
HAIDER AYAD ALIDRISI; | 2023-11-01 |
| 369 | Factors of Control Hypertension or Non-insulin-dependent Diabetes Mellitus Type 2 on The Severity of Stroke and Survival Rates Within 1 Year in Trat Province PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to study factors for controlling hypertension or type 2 diabetes before stroke diagnosis on the severity level when a stroke occurs, NIHSS, … |
PANUWAT SOPONLERTPONG; | 2023-11-01 |
| 370 | A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Therapeutic Exploratory Phase 2 Study to Evaluate The Efficacy and Safety of JP-2266 in Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Abstract: Evaluation of efficacy and safety when administered JP-2266 in type 2 diabetes patients … |
JEIL PHARMACEUTICAL | 2023-11-01 |
| 371 | Effect of A Mobile Application on Blood Sugar Testing Compliance in Pregnant Women With Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effect of using a mobile app versus paper logs on compliance and percentage in range blood sugars in monitoring blood sugar in pregnant women with diabetes. |
CAROLYN ZAHLER-MILLER; | 2023-11-01 |
| 372 | The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in patients with type 2 diabetes. |
UNIVERSITY OF COPENHAGEN | 2023-11-01 |
| 373 | The Effect of Parenterally Administred Semaglutide on Intestinal Iron Absorption in Individuals With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Semaglutide belongs to a group of long-acting glucagon-like peptide 1 receptor agonists (GLP-1). Disorders in iron absorption have been linked to numerous medication, dietary, and nutrient interactions thus far. The study aimed to determine whether there is an effect of concomitant parenteral administration of semaglutide and oral iron preparations on iron absorption in patients with type 2 diabetes (T2DM). |
PETRA MELIŠ; | 2023-11-01 |
| 374 | Can Continuous Glucose Monitors (CGMS) Improve Postpartum (PP) Gestational Diabetes (GDM) Screening for Diabetes? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Among women who experience glucose abnormalities during pregnancy, screening during the postpartum period offers a window of opportunity for early identification of diabetes and prediabetes. The rates of postpartum type 2 diabetes (T2D) screening with an OGTT for women with GDM are not optimal given the majority of women with GDM fail to return for postpartum glucose testing. Continuous glucose monitoring (CGM) systems have been recognized as an ideal method of monitoring glycemic control in diabetic patients. CGM has been used in diabetic patients primarily as a management tool allowing a more acceptable and reliable glucose reading and control than self-monitoring of blood glucose (SMBG). There is a need to improve diabetes testing after childbirth in women who experienced gestational diabetes. This will allow investigators to target their efforts to improve the early diagnosis and treatment of diabetes following GDM. No studies conducted to date have not comprehensively examined whether CGM after delivery can be used in women with a recent history to predict their risk of diabetes. This research study is being done to assess the acceptability, feasibility, and accuracy of using a glucose sensor (also known as a continuous glucose monitor or CGM) after childbirth as a diagnostic test that can help identify women who are at risk of developing diabetes after having gestational diabetes and explore its correlation to the standard postpartum oral glucose tolerance test as well as a HbA1c and fructosamine test. |
KAREN ELKIND-HIRSCH; | 2023-11-01 |
| 375 | Feasibility of Non-invasive Glucose Monitoring By Using Photothermal Deflectometry PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the feasibility of non-invasive glucose monitoring by using photothermal deflectometry in the interstitial fluid of the skin on the wrist of subjects with diabetes mellitus type 1 and 2. |
DIAMONTECH AG | 2023-11-01 |
| 376 | Developing A Diabetes Self-management MHealth Simulation Platform for Youth PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will conduct a 12-week single group feasibility pilot field study among youth who will use a diabetes technology education application in their natural home environment. |
OHIO STATE UNIVERSITY | 2023-11-01 |
| 377 | Exome Evaluation in Patients Living With Diabetes Complicated By Charcot Neuroarthropathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes, like obesity, has reached worldwide proportions such that we’re talking about a pandemic. These two diseases are a major cause of mortality and multiple complications. The medical and financial stakes involved make these two diseases a major public health issue. Two groups of factors contribute to these diseases: the environment and genetics. The use of next-generation sequencing (NGS) is a highly relevant tool for identifying mutations in already known genes, or new genes involved in the disease, … |
CENTRE HOSPITALIER SUD FRANCILIEN | 2023-11-01 |
| 378 | Effect of Cryolipolysis on Insulin Resistance in Type 2 Diabetic Females With Abdominal Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus (DM) is a complex chronic illness associated with a state of high blood glucose level, or hyperglycemia, occurring from deficiencies in insulin secretion, action, or both. Diabetes mellitus is the name given to a wide spectrum group of disorders characterized by raised plasma glucose.Type 1 diabetes is characterized by an absolute insulin deficiency due to autoimmune destruction of insulin producing beta cells in the pancreas. most adults with diabetes have type 2, characterized by a relative insulin secretory defect, and target tissue resistance to the effects of insulin. |
NOURA RAMADAN FAHMY; | 2023-11-01 |
| 379 | A Multi-centre, Prospective, Non-interventional, Single-arm Study Investigating Glycaemic Control Associated With The Use of Dose Check App and IDegLira in Patients With Type 2 Diabetes Mellitus in Italy Under Real-world Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This will study look at how a mobile based app called ‘Dose Check’ used along with Xultophy® helps to control blood sugar level in participants with type 2 diabetes mellitus (T2DM). Participants will get Xultophy® as prescribed by study doctor or will continue already prescribed treatment with Xultophy®. Participants will also be prescribed to use Dose Check app by study doctor. Participants will be asked to install the Dose Check app in their mobile phone, which will support with the correct dose of Xultophy®. The study will last for about 6 to 7 months. |
NOVO NORDISK | 2023-10-30 |
| 380 | Acetylcholine Iontophoresis As A New Challenge With Type 2 Diabetic Peripheral Neuropathy: A Possible New Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators initial study opened the way for randomized trials that monitor the effects of acetylcholine (Ach) iontophoresis vasodilators on endothelial nitric oxide synthetase (NOS) to develop a transdermal treatment that is effective, free from systemic adverse effects. |
REHAM ABDELRAZEK MOHAMED ELLISY; | 2023-10-28 |
| 381 | The Preventive Effect of Probiotics in Pregnant Women With High-risk for Gestational Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Gut microbiota is instrumental in the microbial and metabolic network of pregnant women, and is potentially related with gestational diabetes. Perinatal probiotic intervention contributes to improved glucose regulation during pregnancy. Our randomized, double-centered, placebo-controlled study is planned to recruit 334 pregnant women who is in high risk for gestational diabetes. They will be assumed randomly probiotic powder per day or placebo from 12-16th gestational weeks until Oral Glucose Tolerance Test (OGTT) at 24-28th gestational weeks. Perinatal outcomes about neonatal weight will be registered. |
WOMEN’S HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2023-10-27 |
| 382 | A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate The Efficacy, Safety, Tolerability, and Pharmacokinetics of CT-868 Administered for 16 Weeks to Overweight and Obese Adult Participants with Type 1 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the changes in glycemic control in overweight and obese adults with Type 1 Diabetes Mellitus after receiving CT-868 for 16 weeks. The effectiveness and safety of CT-868 will be compared to placebo. All participants will continue with their standard diabetes care using either an insulin pump (CSII) or multiple daily injections (MDI). Alongside their designated treatment, participants will receive guidance on managing their diabetes, including monitoring blood glucose levels and diet and exercise recommendations. Treatment assignments, either CT-868 plus insulin or placebo plus insulin will be randomly determined. |
CARMOT THERAPEUTICS | 2023-10-19 |
| 383 | Electronic Diabetes Tune-Up Group (eDTU) for African Americans: A Pragmatic Trial Phase 2 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aims of this study are: 1. To test the acceptability and feasibility of the electronic DTU intervention (eDTU) that has been adapted for cultural relevance and online delivery compared to waitlist control and the in-person DTU (iDTU). The hypothesis is that the adapted intervention will be culturally acceptable (by participant satisfaction scores) and well-subscribed (intervention attendance rates). 2. To test differences in diabetes distress and A1c change scores between intervention (changes in T2 to T4) and waitlist control (change in T1 to T2) by intervention group (eDTU vs. waitlist control; … |
MARY DE GROOT; | 2023-10-19 |
| 384 | Relative Hand Grip Strength and Functional Fitness Among Elderly Patients with Type II Diabetes in Egypt: A Cross-sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To show if there is significant relationship between hand grip strength and physical fitness in diabetic type II patients over 60 years old. |
MOHAMMED YOUSSEF ELHAMRAWY; | 2023-10-15 |
| 385 | Novel MHealth Physical Activity Intervention for Youth With Type 1 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this longitudinal cohort study is to learn about a mHealth intervention in Type 1 Diabetes (T1D) The main question[s] it aims to answer are: – Does the intervention increase the amount of text messages between the mHealth software and participants? – Do the text messages from the Nudge software increase moderate to vigorous physical activity (MVPA) in participants? – Does the MVPA encouraged by the Nudge software improve the HbA1c levels of participants? Participants will: – Receive text messages from the Nudge software – Report physical activity goals via the text messages to the Nudge software – … |
MARK CLEMENTS; | 2023-10-01 |
| 386 | Online Diabetes Clinic Support Program for Type 2 Diabetic Individuals New to Insulin Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study highlights the potential of online diabetes clinic support programs in improving treatment adherence, reducing treatment-related anxiety, and enhancing self-management skills in insulin therapy. Telehealth interventions play a crucial role in optimizing diabetes care and supporting patients in managing their insulin treatment effectively. |
DILEK BÜYÜKKAYA BESEN; | 2023-10-01 |
| 387 | Social Media Use in Adolescent Diabetes Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the feasibility of a social media intervention to support diabetes management in adolescents with type 1 diabetes. Adolescent participants will be randomized to receive diabetes education and peer support over Instagram or to usual outpatient diabetes care. Researchers will assess whether the social media intervention is feasible. In addition, the study team will also explore and compare changes in glucose levels and person-reported outcomes between the two groups. |
FAISAL S MALIK; | 2023-10-01 |
| 388 | Molecular Study of Oral Dysbacteriosis in People With Prediabetes and Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the relationship of endocannabinoids in saliva with inflammation and oral dysbacteriosis present in people with periodontal disease and prediabetes/type 2 diabetes |
FRANCISCO J BERMÚDEZ-SILVA; | 2023-10-01 |
| 389 | Informatics-Based Digital Intervention to Promote Safe Exercise in Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes – A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The challenges of living with type 1 diabetes often stand in the way of getting enough exercise. Continuous blood sugar monitoring has revolutionized type 1 diabetes care but remains underutilized to sustainably support exercise and related behaviors. This research will develop a mobile application that delivers personalized encouragement and data-driven health insights based upon patterns in blood sugar, exercise, mood, and sleep, to assist people with type 1 diabetes in exercising more frequently and confidently. |
GARRETT ASH; | 2023-10-01 |
| 390 | Immediate and Prolonged Effects of Self-Thai Foot Massage on Pain, Range of Motion and Functional Disability Among Patients With Type 2 Diabetes Peripheral Neuropathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effect of Self-Thai Foot Massage in type 2 diabetes peripheral neuropathy. The main question is to answer the role of massage in the improvement of peripheral neuropathy. Participants will be taught to perform the Self-Thai Foot Massage at every alternate day for 15 days. Researchers will compare the intervention group with control group (without intervention) to see the improvement in Foot and Ankle Disability Index, Range of Motion and peripheral neuropathy induced Pain. |
AZRA KHANUM; | 2023-10-01 |
| 391 | A Study of Periodontal Health and Its Impact on Oral Health-related Quality of Life Among Diabetes Mellitus Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Periodontal diseases, encompassing a range of inflammatory conditions affecting the supporting structures of the teeth, have long been recognized as a prevalent comorbidity in individuals with diabetes. The severity of periodontal disease is usually documented by research clinicians using clinical parameters such as bleeding on probing (BOP), probing pocket depth (PPD), and clinical. |
NOSHEEN SARWAR; | 2023-10-01 |
| 392 | A Clinical Study Evaluating The Potential Benefit of Nitazoxanide in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus (DM) is a complex metabolic disorder characterized by hyperglycemia and abnormalities in carbohydrate, fat, and protein metabolism. Despite the advancement in anti-diabetic drug therapy, most patients fail to achieve optimal glycemic control. This highlights the need for more effective strategies to control type 2 diabetes mellitus. Nitazoxanide (NTZ), a broad-spectrum anti-infective drug with activity against various protozoa, helminthes, bacteria, and viruses, was identified as peroxisome proliferative activated receptor gamma (PPARγ) agonist using one dimensional drug profile matching. Additionally, it improved insulin sensitivity in insulin-resistant type 2 diabetic rats. Therefore, … |
EMAN GHONAIM; | 2023-10-01 |
| 393 | Effectiveness of Empagliflozin Added to Automated Insulin Delivery (AID) Systems in Adults With Type 1 Diabetes With Sub-optimal Glycemic Outcomes: A Randomized Controlled Parallel Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this 26-week multicenter, randomized, parallel, placebo-controlled trial is to test the effectiveness of empagliflozin use in conjunction with automated insulin delivery (AID) to improve glucose control in individuals with type 1 diabetes who do not meet target recommendations for time in range (3.9-10.0 mmol/L). The main question it aims to answer is: – … |
MELISSA-ROSINA PASQUA; | 2023-10-01 |
| 394 | A Randomized, Crossover, Pilot Trial to Compare Automated Lyumjev Delivery With Carbohydrate Counting, Qualitative Meal-size Estimation, and Meal Detection in Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot trial is to compare three meal strategies using an ultra-rapid insulin (Lyumjev) and an automated insulin delivery system. The meal strategies to be investigated are carbohydrate counting, qualitative meal announcement (e.g., low-carb meal), and meal detection. The investigators are doing this research to evaluate if carbohydrate counting can be simplified in patients with type 1 diabetes. Participants will test each meal strategy in random order, and each meal strategy will be 21 days long. For the duration of each meal strategy, … |
MICHAEL TSOUKAS; | 2023-10-01 |
| 395 | Effect of Buerger Allen Exercise on Peripheral Circulation Among Patients With Type 2 Diabetes Mellitus in A Tertiary Care Hospital, Lahore: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized control trial aims to compare peripheral circulation in type 2 diabetes mellitus. This study aims to determine the effect of the Buerger-Allen exercise (BAE) on peripheral circulation among patients with type 2 diabetes mellitus in a tertiary care hospital, Lahore. Participants will perform the Buerger -Allen exercise with routine care control group: Researchers will compare with routine care |
SANA ZREEF; | 2023-10-01 |
| 396 | A Phase 3, Long-term Safety Study of LY3502970 in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone or in Combination With Oral Antihyperglycemic Medications (ACHIEVE-J) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the long-term safety of the study intervention orforglipron as a monotherapy or in combination with oral antihyperglycemic medication. This study includes 3 periods as follows: * screening and lead-in period: up to 4 weeks * treatment period: 52 weeks, including 20 weeks of dose escalation, and * safety follow-up period: 2 weeks. |
ELI LILLY | 2023-09-28 |
| 397 | Relationship Between Nutritional Status, Hand Grip Strength, and Fatigue in Hospitalized Older Adults With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As the proportion of the elderly population increases, so does the number of people suffering from diabetes mellitus (DM). Fatigue is common in elderly patients with type 2 diabetes, and malnutrition may lead to a decrease in muscle strength, thereby aggravating their fatigue symptoms; however, there is still a lack of relevant research on this group in Taiwan. Therefore, the purposes of this study are to understand the current status and correlation of basic attributes, nutritional status, handgrip strength and fatigue in hospitalized older adults with type 2 diabetes mellitus. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2023-09-26 |
| 398 | A Phase 3, Randomized, Open-Label Study to Investigate The Efficacy and Safety of Once Daily Oral LY3502970 Compared With Oral Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin (ACHIEVE-3) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess efficacy and safety of orforglipron compared with oral semaglutide in participants with Type 2 diabetes and inadequate glycemic control with metformin.The study will last around 61 weeks. |
ELI LILLY | 2023-09-22 |
| 399 | A Phase 2, Randomized, Double-blind, Placebo-Controlled Study to Assess The Efficacy and Safety of Investigational Tirzepatide Doses in Participants With Type 2 Diabetes and Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to learn more about the safety and efficacy of investigational tirzepatide doses in participants with Type 2 diabetes and obesity that are already taking metformin. The study will last for about 89 weeks. |
GILBERT JENOURI; | 2023-09-21 |
| 400 | Risk of Malaria and Other Parasitic Infections in Individuals With Type 2 Diabetes With or Without Metabolic Syndrome in Cameroon PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-communicable diseases (NCDs) such as diabetes are increasing in countries where malaria transmission is common. This study aims to investigate the relationship between NCDs and parasitic infections in Cameroon. The investigators will assess the risk of malaria, as well as other parasitic diseases, in a prospectively followed group of adults with diabetes, compared with those without diabetes. Malaria parasites and intestinal worms will be tested using blood and stool collected at four time points during a one-year follow-up. In addition, this project will investigate how natural protection against malaria is affected by diabetes and other risk factors for heart diseases. |
GEORGE AWUNGAFAC; | 2023-09-21 |
| 401 | A Multicenter, Randomized, Open-label, Parallel-controlled Phase III Clinical Study Comparing The Efficacy and Safety of Semaglutide Injection with Ozempic ® in Patients with Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control with Metformin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 32-week randomized, open-label, parallel-controlled biosimilar comparison study comparing the efficacy, safety and immunogenicity of the investigational drug and the active comparator in patients with type 2 diabetes mellitus who have inadequate glycemic control with metformin. Eligible participants will be screened and randomized to the experimental group and the active comparator group at a ratio of 1:1 , … |
HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL | 2023-09-20 |
| 402 | Green Digital Diabetes Waste Project: Quantifying The Amount of Environmental Waste Associated With Devices and Technology PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine how people with diabetes are disposing of various products and devices and at what rates so that better devices with less waste can be designed in the future. |
JING WANG; | 2023-09-19 |
| 403 | Improving Diabetes Equity and Advancing Care Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized trial is to determine the optimal combination and sequence of three enhancements for a team-based care model for patients living with diabetes in Chicago. The study aim is to determine optimization of intervention components. Participants will be randomly assigned to diabetes self-management training or remote glucose monitoring. After 6 months, participants will be rerandomized to a subsequent study arm (including a CHW support program) depending on a tailoring variable of change in A1c. Researchers will compare the final 6 study arms to see which combination and sequence of enhancements produces the most improvement in A1c. |
SINAI HEALTH SYSTEM | 2023-09-15 |
| 404 | PROmoting Diabetes Education and Management Through Peer Support and Team Referral PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A 3-step project is proposed. Step 1 will test which BPA time point(s) maximize referral rates to DSMES services in the real world clinic setting (Aim 1). Step 2 will utilize that approach within a pilot study of six sites, comparing the effectiveness of peer support to improve attendance to DSMES services (Aim 2). Step 3 will engage stakeholders in designing a future large scale DSMES services trial to improve referral and attendance to DSMES classes. |
LAURA YOUNG; | 2023-09-12 |
| 405 | Investigation of The Influence of Postural Control, Ankle and Trunk Proprioception in Patients With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators aim to assess the postural control, ankle, and trunk proprioception, plantar sensation, and general cognitive status in patients with Type 2 diabetes. |
GÜNSELI USGU; | 2023-09-10 |
| 406 | Using Closed-Loop Artificial Pancreas Technology to Reduce Glycemic Variability and Subsequently Improve Cardiovascular Health in Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes. AP technology is a system of devices that closely mimics the glucose-regulating function of a healthy human pancreas. It includes an insulin pump and a continuous glucose monitor (CGM). In this study, the investigators will research whether improvements in blood glucose levels and blood glucose variability will in turn decrease biomarkers of inflammation and endothelial dysfunction while improving cardiovascular function. |
WILLIAM HORTON; | 2023-09-09 |
| 407 | A Single Arm Study Investigating The Glycaemic Control and Safety of Adding Semaglutide to Insulin Icodec in Participants With Type 2 Diabetes Qualifying for Treatment Intensification PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study looks at how a new medicine insulin icodec helps in reducing blood sugar levels when given along with semaglutide in patients with type 2 diabetes. Participants will get the medicine insulin icodec once a week in the first part of the study (run-in period-26 weeks). Participants will only enter the second part of the study if the blood sugar levels have not reduced to normal. If blood sugar levels are normal after the first 26 weeks, participants will continue in a 5-week follow up period. In the second part of the study (intensification period-26 weeks), … |
NOVO NORDISK | 2023-09-05 |
| 408 | Evaluating Glucose Control Using A Next Generation Automated Insulin Delivery Algorithm in Patients With Type 1 and Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the safety and effectiveness of a next-generation automated insulin delivery algorithm in participants aged 16+ years with type 1 or type 2 diabetes. |
MARTIN DEBOCK; | 2023-09-05 |
| 409 | CloudCare Patient Reported Outcomes in The Treatment of Type 1 Diabetes in Pediatrics A Prospective Cohort Study in Europe PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective cohort study aims to estimate the effect of the CloudCare application in daily practice on treatment satisfaction and emotional burden for pediatric patients and their parents/caregivers, patients’ glycemic control (glucometrics), healthcare professional satisfaction, and the impact on costs. A total of 600 pediatric patients (1-15 years) with type 1 diabetes will be enrolled into the study. |
DIABETER NEDERLAND BV | 2023-09-01 |
| 410 | Transform CV Risk in Diabetes PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This initiative supports a real-world study of practice and physician prescribing patterns and a quality improvement initiative evaluating best practices (including clinical decision support, facilitated referral to cardiometabolic team-based care model, and general educational tools/resources) to im-prove use of guideline-directed therapeutics known to lower cardiovascular risk (CV) in patients with type 2 diabetes (T2D). |
AMERICAN COLLEGE OF CARDIOLOGY | 2023-09-01 |
| 411 | New Markers of Glycation to Predict Gestational Diabetes Mellitus and Macrosomia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Gestational diabetes mellitus (GDM) increases the risk of macrosomia and other adverse pregnancy outcomes. Screening strategies are debated: universal vs. selective, and macrosomia may begin before the time of screening, suggesting that glycation markers may have an interest. The objective of this trail is to compare novel markers: skin autofluorescence and glycated albumin, to HbA1c (reference) as predictors of GDM, macrosomia and other adverse outcomes, in pregnant women. |
SENTILHES LOIC; | 2023-09-01 |
| 412 | Serum Magnesium Level in Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. It may be due to impaired insulin secretion, resistance to peripheral actions of insulin, or both . Chronic hyperglycemia in synergy with the other metabolic aberrations in patients with diabetes mellitus can cause damage to various organ systems, leading to the development of disabling and life-threatening health complications, most prominent of which are microvascular (retinopathy, nephropathy, … |
HASNAA MOHAMED KAMEL; | 2023-09-01 |
| 413 | Continuous Assessment of Risk and Efficacy (CARE) Using Health Coaching, Continuous Glucose Monitoring and AI Mobile App in Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Lifestyle change is key to diabetes management but there are limited resources and time to support patients in improving lifestyle behaviour in the current healthcare system. Currently, health coaching for behavioural chance guided by continuous glucose data, wearable and lifestyle data is not available in primary and tertiary care management of diabetes. This parallel-group randomised controlled trial (RCT) aims to investigate the effectiveness of a novel multi-component model of care comprising interventions including the mobile app EMPOWER and smartwatch, health coaching, and continuous glucose monitoring (CGM). |
SINGAPORE GENERAL HOSPITAL | 2023-09-01 |
| 414 | The Effect of Oral Magnesium Supplementation on The Control and Outcomes of Type II Diabetes Mellitus Guided By Serum Ionized Magnesium Level: A Double-Blind Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Studies have shown that type 2 diabetic patients (T2DM) may have low serum magnesium levels leading to poor control and outcome of the disease. Supplementation with Mg might improve overall diabetic control and disease outcome. However, there is yet no consensus on whether the ionized (iMg) or the total Mg (tMg) level should be used as a basis to determine the status of Mg in the blood. Recently it was shown that iMg may correlate better with diabetes control than tMg. Therefore, Mg supplements to diabetic patients may improve their disease status. Unfortunately, … |
MOHAMMED AL ZA’ABI; | 2023-09-01 |
| 415 | The Effect of Watson’s Human Care Theory-Based Motivational Interviewing on Treatment Adherence, Self-Efficacy, and Satisfaction in Individuals With Diabetic Foot Ulcers: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The rise in diabetes incidence has led to a corresponding increase in diabetes-related complications. Diabetic foot ulcers, a severe consequence of diabetes, have substantial impacts on patients, the social environment, overall well-being, and nursing procedures. Given this context, there is a clear necessity for interventions that motivate patients to adopt beneficial health behaviors and educate them in effectively managing diabetes-related complications. This study seeks to investigate the impact of Watson’s motivational interviewing method, which is grounded in the human care theory, on enhancing treatment adherence, self-efficacy, … |
NIDA EFETÜRK; | 2023-09-01 |
| 416 | Comparison of The Immediate Effects of Soleus Pushup Exercise and Treadmill Walk on Blood Glucose Levels in Type 2 Diabetes Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research is to compare the immediate effects of one hour Soleus Pushup Exercise and treadmill walk in Type 2 Diabetic population on blood glucose level. Randomized controlled trials done at Railway General Hospital and diabetic centers of Rawalpindi and Islamabad.. The sample size was 66. The subjects were divided in two groups, … |
AISHA RAZZAQ; | 2023-09-01 |
| 417 | Integrated Behavioral Healthcare for Low-Income Ethnic Minority Youth With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to understand how behavioral health care that is coordinated with diabetes medical care compared with behavioral care that is provided in the community (and therefore not coordinated with diabetes medical care). |
LUIZA VIANNA MALI; | 2023-09-01 |
| 418 | Grocery Prescription Program for Medicaid Adults With Hypertension or Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the effectiveness of a grocery prescription program in adults diagnosed with either Type 2 Diabetes Mellitus or Hypertension. Participants will enroll in Instacart Fresh Funds program. Once enrolled each week participants will select foods that are eligible in the Fresh Funds Program to be delivered to their home for 12 weeks. Participants will also participate in a survey at the beginning of the study and at the end of the study. |
ALISON GUSTAFSON; | 2023-09-01 |
| 419 | The Effect of Self-Care Disability Theory-Based Web-Based Education for Individuals With Type-2 Diabetes on Care Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Type and Aim of Research This research will be conducted as a randomised controlled experimental study design to test the effect of web-based diabetes education on the quality of life and self-care activities of individuals with Type 2 Diabetes. Place and Time of the Study This research will be conducted between September 2023 and March 2024 with individuals registered to the Cyprus Turkish Diabetes Association. Population and Sample of the Study The population of the study consisted of individuals with Type-2 diabetes who applied to the Cyprus Turkish Diabetes Centre. The sample of the study included individuals with type-2 diabetes who met the inclusion criteria at the Turkish Cypriot Diabetes Centre. Sample size was calculated using G Power statistical programme (n=74). In order to evaluate the effectiveness in the experimental and control groups, simple randomisation was performed to ensure the similarity of the two groups. Randomisation was applied after the pre-tests. The data of the study will be collected by Sociodemographic Data Form, Diabetes Specific Quality of Life Scale, Diabetes Self-Care Activities Questionnaire, Website Analysis and Measurement Inventory and DISCERN Measurement tool. The forms will be applied to the participants face to face. People in the experimental group, whose information was sent to the researcher, will receive reminder messages twice a week (Wednesday-Friday) during the 3-month follow-up period via the website. No intervention will be applied to the control group. The post-test will be applied. |
KEMAL ELYELI; | 2023-09-01 |
| 420 | Role of Adrenaline in The Inflammatory Response in People With Diabetes Mellitus Type 1, and Healthy Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of the present study is to study the effect of adrenaline administration on inflammatory parameters (e.g. leukocyte phenotype, cytokines, inflammatory proteins). Secondary objectives consist of the effect of adrenaline on atherogenic parameters. – All participants will receive intravenous infusion of adrenaline for an hour – We will draw blood at 7 time points, not including screening – Participants will be asked to return for a total of 4 times Researchers will compare 2 groups, healthy individuals versus people with diabetes type 1 to see if the inflammatory reaction to adrenaline differs between these two groups. |
CEES TACK; | 2023-09-01 |
| 421 | A Multi-Center, Randomised, Double-blind, Placebo Parallel Controlled Clinical Study to Evaluate The Efficacy and Safety of Chiglitazar Added to Glargine in Patients With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the Efficacy and Safety of Chiglitazar Added to Patients with type 2 diabetes who do not respond well to metformin combined with insulin glargine. The main question it aims to answer are: • T2DM patients still cannot effectively control their blood sugar with the combination of insulin and metformin. The combination of follow-up treatment and hypoglycemic drugs is worth exploring, … |
YANBING LI; | 2023-08-31 |
| 422 | A Phase 2 Clinical Trial Comparing The Efficacy and Safety of Once-weekly GZR4 Injection Versus Once-daily Insulin Degludec in Subjects With Type 2 Diabetes Mellitus on OAD Therapy or OAD Therapy in Combination With Basal Insulin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares the efficacy, safety, and tolerability of once-weekly GZR4 Injection versus once-daily insulin degludec in patients with type 2 diabetes mellitus in inadquete control on oral antidiabetic drug (OAD) therapy or OAD Therapy in combination with basal insulin. |
GAN AND LEE PHARMACEUTICALS USA | 2023-08-29 |
| 423 | Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes: A Randomized, Double-blind, Placebo-controlled, Investigator-initiated Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to evaluate if colchicine in addition to standard of care improves markers of inflammation and cardiovascular disease in persons with type 1 diabetes. Participants will be assigned to either 0,5 mg colchicine daily or placebo in a 1:1 ratio for 26 weeks with the possibility of an additional 26 week extension of the intervention period. |
ASGER LUND; | 2023-08-29 |
| 424 | Evaluation of Selected Improved Outcomes Among Patients With Diabetes And/or Hypertension in Designated Community Pharmacies in A Metropolitan City – An Intervention Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional study is to compare improved outcomes among diabetes and/or hypertensive patients sequel to educational intervention. The study aims to answer the following questions: – What are the patients’ levels of health literacy, medication adherence, disease knowledge, attitude to disease, physical activity? – Does educational intervention by pharmacists improve health outcomes of patients with diabetes and/or hypertension? – Are there associations between patient-related variables such as health literacy, medication adherence, disease knowledge, attitude to disease? Participants’ anthropometric measurements and point-of-care testing for disease monitoring e.g., blood pressure, … |
AKINNIYI AKINBIYI AJE; | 2023-08-28 |
| 425 | Improving Transition Care for Adolescents and Young Adults With Type 1 Diabetes: A Randomized Controlled Trial of SHIFT2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to evaluate a transition preparation program designed for adolescents and young adults (AYAs) with type 1 diabetes (T1D). This transition program will support AYAs as they prepare to transition from pediatric to adult endocrinology medical care and will also include a caregiver. Results from this study will inform clinical recommendations regarding self-management best practices for AYAs with T1D prior to transitioning to adult medical care. |
LAURA CACCAVALE; | 2023-08-24 |
| 426 | Refinement and Adaption of Reinforcement Learning to Personalize Behavioral Messaging for Healthy Habits PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Reinforcement learning is an advanced analytic method that discovers each individual’s pattern of responsiveness by observing their actions and then implements a personalized strategy to optimize individuals’ behaviors using trial and error. The goal of the proposed research is to refine, … |
JULIE LAUFFENBURGER; | 2023-08-23 |
| 427 | A Randomized, Double-blind, Placebo-controlled Study to Investigate The Efficacy and Safety of Tirzepatide Monotherapy Compared With Placebo in Chinese Participants With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to investigate the efficacy and safety of Tirzepatide monotherapy in Chinese participants with Type 2 Diabetes. |
YIMING MU; | 2023-08-21 |
| 428 | Peer Comparison-based Risk Communication (PRICOM): A Study Protocol to Evaluate The Feasibility of Delivering A Risk Communication Intervention in The Primary Care Setting for Adults with Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study objective is to evaluate the feasibility of delivering a risk communication intervention, Peer comparison-based Risk Communication (PRICOM), in the primary care setting for adults with poor T2DM control. Findings from the study will inform further revisions to PRICOM and provide an estimated effect size to estimate the required sample size for a multi-site trial. |
ONG RUIHENG; | 2023-08-21 |
| 429 | Effectiveness of The Mobile Application-delivered Resistance Program for Children and Adolescents With Type 1 Diabetes (Diactive-1) on Insulin Requirements: Protocol for A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project involves a two-arm randomized controlled trial (RCT) designed to assess the feasibility, acceptability, and preliminary efficacy of a mobile application aimed at prescribing resistance training for children and adolescents with type 1 diabetes (Diactive-1). The program will span 24 weeks, … |
ANTONIO GARCÍA-HERMOSO; | 2023-08-20 |
| 430 | Improving Access to Diabetes Education and Care for Deaf Populations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the feasibility and preliminary efficacy of a 10-week intervention called Deaf Diabetes Can Together. |
MICHELLE LITCHMAN; | 2023-08-17 |
| 431 | Effect of Continuous Glucose Monitoring System Alerts on Diabetes Management in The Hospital: A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Current continuous glucose monitoring (CGM) devices provide features that alert for current and impending adverse glycemic events.This trial aims to examine whether these glucose alerts provided added benefit on glycemic outcomes in patients with type 1 or 2 diabetes who required intensive insulin therapy during hospitalization. |
JIAN ZHOU; | 2023-08-14 |
| 432 | A Multi-center, Randomized, Double-blind, Placebo- Parallel Controlled, Phase II Study to Evaluate The Efficacy and Safety of HRS9531 Injection in Type 2 Diabetes Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and dose-response relationship of HRS9531 injection versus placebo in controlling blood glucose after 20 weeks of treatment in subjects with type 2 diabetes who have suboptimal glycaemic control after conventional lifestyle or metformin intervention. |
FUJIAN SHENGDI PHARMACEUTICAL | 2023-08-12 |
| 433 | Self-Management and Glycemic Control in Adult Haitian Immigrants With Type 2 Diabetes: A Pilot Randomized Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to conduct a pilot randomized study to test feasibility and preliminary efficacy of the developed diabetes self-management education program with 40 adult Haitian immigrants. |
CHERLIE MAGNY-NORMILUS; | 2023-08-12 |
| 434 | Investigating The Relationship Between Triglycerides and Fetal Overgrowth in Gestational Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, observational study which examines the association between maternal triglycerides in the antepartum period and fetal overgrowth in pregnancies complicated by gestational diabetes. Mothers are asked to provide 2 blood samples, undergo fingerstick blood measurements, and to have their newborns measured for body fat composition in the first 6 months of life. |
GENE LEE; | 2023-08-10 |
| 435 | A Phase 3, Randomized, Double-Blind Study to Investigate The Efficacy and Safety of Once Daily Oral LY3502970 Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine safety and efficacy of orforglipron compared with placebo in adult participants with type 2 diabetes and inadequate glycemic control with diet and exercise alone. The study will last approximately 54 weeks. |
ELI LILLY | 2023-08-09 |
| 436 | A Multicenter, Randomized, Controlled Phase II Clinical Trial to Evaluate The Efficacy and Safety of GZR18 Injection in Chinese Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was a multicenter, randomized, parallel and controlled study in adult patients with T2DM to evaluate the efficacy, safety (including immunogenicity) and pharmacokinetics of GZR18 injection in adult patients with T2DM. |
GAN AND LEE PHARMACEUTICALS USA | 2023-08-09 |
| 437 | Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this longitudinal clinical trial is to measure variability of interstitial glucose levels with a user-friendly real-time continuous glucose monitoring (CGM) technology at regular intervals in normo- and dysglycemic multiple autoantibody-positive first-degree relatives (age 5-39 years) of type 1 diabetes patients, in comparison with single autoantibody-positive relatives in the same age range. Participants will asked to undergo repeated oral glucose tolerance tests (OGTTs) (age 5-39 years) and hyperglycemic clamp tests (age 12-39 years) in parallel for a period of at least 2-3 years. In case of confirmed dysglycemia, … |
BART KEYMEULEN; | 2023-08-09 |
| 438 | Treating Early Type 2 Diabetes By Reducing Postprandial Glucose Excursions: A Paradigm Shift in Lifestyle Modification PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Randomized Control Trial (RCT) with 1:1 randomization of adults newly diagnosed with type 2 diabetes (T2D) to Routine Care (RC) and RC + Glycemic Excursion Minimization (RC+GEM); a program that provides RC in addition to continuous glucose monitors (CGM) within a structured, self-directed, and personalized lifestyle program called GEM. Our hypothesis is that RC+GEM will: 1) reduce hemoglobin A1c as much or more, 2) require less diabetes medication, 3) cost less, and 4) have more secondary benefits, (e.g. greater reduction in cardiovascular risk, weight, diabetes distress, depression symptoms), compared to RC alone. |
CHIARA FABRIS; | 2023-08-08 |
| 439 | The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and With Type 1 and 2 Diabetes: An Exploratory Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Exhaled volatile organic compounds will be measured during daytime with the goal to identifying circadian variability. The study incudes three subgroups: people without diabetes, people with type 1 diabetes, and people with type 2 diabetes. A total of 60 people will be recruited for the study. |
LILIAN WITTHAUER; | 2023-08-02 |
| 440 | Establishment and Clinical Application of Pancreatic Endocrine and Exocrine Function Tests PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to improve the epidemiological data of pancreatic exocrine insufficiency in China, determine the FE-1 cut-off value for the classification of PEI, and explore the characteristic differences between T3cDM and type 2 diabetes mellitus in clinical symptoms and laboratory indicators. |
ZHAOSHEN LI; | 2023-08-01 |
| 441 | Sterile Wound Care Liquid Dressing in Treatment of Diabetes Foot Ulcer: A Randomized Control Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized control trial is to test the efficacy and safety of the sterile wound care liquid dressing in patients with diabetes foot ulcer in different stages. The main question it aims to answer are: – Whether the sterile wound care liquid dressing have better efficacy and safety than blank control in treatment of diabetes foot ulcer in infection progressive stage？ – Whether the sterile wound care liquid dressing have better efficacy and safety than blank control in treatment of diabetes foot ulcer in necrosis stable stage？ – … |
LONG ZHANG; | 2023-08-01 |
| 442 | Sleep for Health: A Randomized Clinical Trial Examining The Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study tests whether providing cognitive behavioral therapy for insomnia (CBT-I) to people with prediabetes results in a reduction in glucose levels compared to a patient education control program. |
ERIN LEBLANC; | 2023-08-01 |
| 443 | Polypill Versus Metformin in New Onset Type 2 Diabetes: A Low Dose Triple Therapy Polypill Versus Metformin for Glycaemic Control in Newly Diagnosed Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the effect of the GMRx4 polypill compared to metformin monotherapy on glycosylated haemoglobin (HbA1c) when used as first line therapy in adults with recently diagnosed Type 2 Diabetes. The main question it aims to answer is: That the GMRx4 polypill, compared to metformin, … |
GEORGE MEDICINES PTY | 2023-08-01 |
| 444 | Fresh Carts for Mom’s to Improve Food Security and Glucose Management PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at the benefit of decreasing food insecurity and improving glucose control among women who either report gestational diabetes (GDM) at 20-28-weeks or have type 2 diabetes (T2DM) with a confirmed pregnancy. Participants will receive a grocery prescription with delivery through Instacart at the start of the study or after 12 weeks or frozen medically tailored meals delivered from Door Dash. Researchers will compare the grocery prescription program, MTM (medically tailored meals), … |
ALISON GUSTAFSON; | 2023-08-01 |
| 445 | Improving Glycemic Control Using A Virtual Weight Control Program and Continuous Glucose Monitoring in Adults With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized clinical trial with the primary aim examining the efficacy of a novel integrated solution of a digitally delivered behavioral weight management program tailored for diabetes utilizing a continuous glucose monitor (CGM) built into the WW digital platform for adults with type 2 diabetes (T2D) for the reduction of HbA1c. |
PETER T. KATZMARZYK; | 2023-08-01 |
| 446 | Continuous Glucose Monitor Use for Mayo Clinic Advanced Care at Home Patients With Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to measure differences in diabetes control with the use of continuous glucose monitor (CGM) and diabetes education compared with standard of care for glucose monitoring (glucometer checks) and diabetes education in participants with diabetes mellitus receiving therapy with insulin and being admitted to Mayo Clinic Advanced Care at Home Program (ACH). |
ADRIAN G. DUMITRASCU; | 2023-08-01 |
| 447 | National, Multicenter, Randomized, Double-blind, Triple-dummy, Phase III Clinical Trial to Evaluate The Efficacy and Safety of Egito Association in The Treatment of Type II Diabetes Mellitus and Hypertension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and safety of Egito association in the treatment of type 2 diabetes mellitus and hypertension |
EMS | 2023-08-01 |
| 448 | Construction and Preliminary Verification of InterventionImpact of An IMB Theory-based Health Education Intervention on Hypoglycemic Coping in Patients With Type 2 Diabetes: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: From August 2023 to January 2024, 100 patients with type 2 diabetes who met the inclusion and exclusion criteria were selected from the endocrinology department of The purpose of this study was to construct a hypoglycemia coping intervention program for type 2 diabetic patients based on the IMB theory and to investigate the feasibility, acceptability, and initial effects of the program. |
YATING LIU; | 2023-08-01 |
| 449 | Feasibility Assessment of A Diabetes Specialist Nurse-led Multi-component Smoking Cessation Intervention for Individuals Living With Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the feasibility and acceptability of a multi-component smoking cessation intervention for individuals living with diabetes which is delivered by diabetes specialist nurses. The main question it aims to answer is: Is a diabetes specialist nurse-led multi-component smoking cessation intervention tailored for persons living with diabetes who smoke feasible and acceptable among the providers and the participants, … |
JOSEPH GRECH; | 2023-08-01 |
| 450 | Therapeutic Effects and Effects on Body Fat of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes for 1-4 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The efficacy of long-term treatment with different GLP-1RA (Duragtide, Semaglutide, losenatide, tirzepatide, ebenatide, etc.) was evaluated through 1-4 years of follow-up, and the effects of long-term treatment on blood glucose and body fat of patients. |
NANJING FIRST HOSPITAL NANJING MEDICAL UNIVERSITY | 2023-08-01 |
| 451 | Characteristics of Blood Glucose Variability in Patients With Type 2 Diabetes Mellitus Complicated With COVID-19 and Its Effect on The Prognosis of The Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: using intermittently scanned continuous glucose monitoring (isCGM) to clarify the characteristics of blood glucose variability parameters in T2DM patients with NCP, guide the formulation of reasonable clinical treatment measures and make timely and reasonable adjustments, improve the prognosis of patients, shorten the length of hospital stay, … |
KUANXIAO TANG; | 2023-08-01 |
| 452 | A Pilot Human Investigation of The Safety, Tolerability and Effectiveness of The Aqua Medical Circumferential RF Vapor (RFV) Ablation System for Duodenal Mucosal Ablation for The Management of Type-2 Diabetes Mellitus (STEAM T-2DM Pilot) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical study is to test the hypothesis that RF vapor ablation of the duodenal mucosa will result in improvement in glycemic parameters, without complications (bleeding/ stricture / perforation). The main aims of the study are : 1. Evaluate the safety of the device and procedure based on the reported adverse events that occur. 2. Evaluate the effectiveness of the device and procedure by comparing change in HbA1c from baseline to 168 days post procedure. 3. Evaluate device tolerability based on pain scores reported by patients. The subject population for this study are adults (18-65 years of age) with type-2 diabetes mellitus. Study participation is 6 months for each patient. The study is comprised of 4 phases: Screening, Run-in, RF Vapor ablation procedure, and Post-vapor ablation follow-up (up to 168 days). |
AQUA MEDICAL | 2023-08-01 |
| 453 | Outcome of Complete Pulpotomy in Healthy and Type 2 Diabetic Patients in Permanent Teeth with Irreversible Pulpitis – A Preliminary Prospective Interventional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Endodontic research on the effects of DM on pulp tissues is scarce. Diabetic human and animal histological research demonstrated a decreased reparatory response in the pulp, resulting in chronic pulp inflammation and reduced dentin bridge formation. To date, there is no human clinical trial examining the impact of diabetes mellitus on teeth with irreversible pulpitis. As a result of the paucity of data in the literature, there is a clinical dilemma whether to recommend vital pulp therapy techniques or root canal treatment in diabetic patients with irreversible pulpitis. To the best of our knowledge, … |
KEERTHANA G; | 2023-08-01 |
| 454 | Patient Versus Provider-led Titration of Insulin for Glycemic Control in Gestational Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We propose a pragmatic, unblinded, randomized controlled, single center trial of 56 pregnant individuals with Gestational diabetes mellitus (GDM). Our study proposes a pragmatic randomized control trial of patient led rapid titration of basal insulin compared to standard therapy. There is a planned subgroup analysis of patients with and without concomitant metformin usage. Patients will continue routine clinic visits. Patients who are initiated on basal insulin or started on night-time basal insulin within 7 days will be approached about the study. Patients who agree to be enrolled will sign informed consent. |
KARTIK K VENKATESH; | 2023-08-01 |
| 455 | Examining The Influence of Guided Meditation on Diabetes-related Distress and Glycemic Control: A Randomized Controlled Trial Among Hospitalized Type 1 Adolescent Diabetic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to investigate the effects of Guided Meditation on diabetes-related distress and glycemic control in hospitalized Type 1 adolescent diabetic patients. The study will employ a randomized controlled trial design, with participants randomly assigned to either the intervention group (receiving Guided Meditation sessions) or the control group (receiving standard care). The primary outcomes measured will be diabetes-related distress levels and glycemic control (HbA1c levels). |
SAIMA ABASS TAHAMMAL; | 2023-08-01 |
| 456 | Perspectives on Using A Nutrition-focused Approach When Initiating Continuous Glucose Monitoring in People With Type 2 Diabetes: A Qualitative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the qualitative research is to provide a deeper understanding of the perspectives of people with type 2 diabetes (T2D) who received a nutrition-focused approach (NFA) when initiating continuous glucose monitor (CGM). |
HOLLY WILLIS; | 2023-08-01 |
| 457 | A Phase 2a Randomized, Double-blind, Placebo-controlled, Multiple-dose, Crossover Study of The Effect of ZT-01 on Frequency of Nocturnal Hypoglycemia in Type 1 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the effect of the study drug (ZT-01) on low blood sugar (hypoglycemia) in adults with type 1 diabetes (T1D) who have been having low blood sugars (hypos) at night. ZT-01 increases the amount of a hormone called glucagon during low blood sugar, and this may help prevent the occurrence of hypos. The main questions this trial aims to answer are whether ZT-01 lowers the number of hypos happening at night, … |
ZUCARA THERAPEUTICS | 2023-07-28 |
| 458 | A Multicenter, Prospective, Non-interventional, Observational Study to Evaluate The Efficacy and Safety of Dapagliflozin in Patient With Type 2 Diabetes Mellitus and Hypertension PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to evaluate the efficacy and safety of dapagliflozin in patient with type 2 diabetes mellitus and hypertension |
BORYUNG PHARMACEUTICAL | 2023-07-26 |
| 459 | A Phase 2b, Double-Blind Study to Investigate The Effect of Retatrutide on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to investigate the effect of retatrutide on renal function in participants with overweight or obesity and chronic kidney disease (CKD), with or without Type 2 Diabetes (T2D). The study will last around 31 weeks. |
YESSICA SACHDEVA; | 2023-07-20 |
| 460 | The Effects of Resistance Exercise on Cognition in People With Type 1 Diabetes: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the current study is to determine the effects of resistance exercise on performance of the Paced Auditory Serial Addition Test and the Colour Trails Test. |
EBAA AL OZAIRI; | 2023-07-20 |
| 461 | Istanbul University-Cerrahpasa, Florence Nightingale Faculty of Nursing, Department of Medical Nursing PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the effect of planned education given to individuals with diabetes mellitus who had myocardial infarction on healthy lifestyle behaviors and diabetes self-management. |
ARZU ERKOC; | 2023-07-15 |
| 462 | A Master Protocol to Investigate The Efficacy and Safety of LY3437943 Once Weekly in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight: A Randomized Double-Blind, Placebo-Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of participants who have obstructive sleep apnea (OSA) (J1I-MC-GSA2). The study will last about 89 weeks and will include up to 24 visits. |
ELI LILLY | 2023-07-11 |
| 463 | SKAMo-2: The Real-life Test of Continuous Photoacoustic Signal By Neogly in Patients With Type I Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes is one of the very common and chronic diseases in the present world, which affects children and adults. Diabetes is characterized by hyperglycemia. Hence, diabetic patients need to precisely monitor their blood sugar level regularly a few times a day. Currently, the solutions for self-monitoring blood glucose are invasive (finger prick method, continuous glucose monitoring (CGM) using microneedle).The fully non-invasive CGM approaches still are in high demand. The medical device is developed, ultimately, to continuously measure the blood glucose level from continuous in-vivo photoacoustic signal. For this study, … |
PIERRE-YVES PR BENHAMOU; | 2023-07-06 |
| 464 | To Assess Prevalence of Sarcopenia Using Hand Grip Strength (HGS) As A Marker in Patients With T2DM PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Hand grip strength will be measured for all the type 2 diabetic patients. Measurement of maximal grip strength will be performed using Jamar dynamometers, which estimate the muscle strength primarily generated by the flexor muscles of the hand and the forearm. The Jamar displays grip force in both pounds and kilograms, with a maximum of 200 lb (90 kg). It has a peak-hold needle that automatically retains the highest reading until reset. The Jamar test is isometric, with no perceptible motion of the handle, … |
ANOOP MISRA; | 2023-07-01 |
| 465 | Usefulness of Intermittently Scanned Continuous Glucose Monitoring in The Diagnosis of Maturity-onset Diabetes of The Young (MODY) Patients PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Observational study about usefulness of intermittently scanned continuous glucose monitoring (isCGM) in the diagnosis of maturity-onset of the young (MODY) patients. |
JESUS MORENO-FERNANDEZ; | 2023-07-01 |
| 466 | A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To conduct a pragmatic, non-blinded randomized controlled trial (pRCT) of immediate in-patient postpartum OGTT prior to delivery discharge (intervention) versus 4-12 week outpatient postpartum OGTT (current standard care) to improve the frequency of post-partum diabetes screening among individuals with a pregnancy complicated by GDM. |
KARTIK K VENKATESH; | 2023-07-01 |
| 467 | Association of Xanthelasma With Sub Clinical Atherosclerosis and Hepatic Fat: A Case Control Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with diabetes with clinical feature of Xanthelasma will show increased Atherosclerosis. Objectives: Primary 1. To correlate xanthelasma and its severity to pulse wave velocity and atherosclerosis as see in carotid doppler. Secondary 2. To correlate xanthelasma to liver fat and fibrosis. Methodology: T2DM patient will be recruited from endocrine OPD 1. Clinical History and Examination: a. General Physical Examination: Height, weight, waist circumference, hip circumference, BMI, Blood Pressure, … |
ANOOP MISRA; | 2023-07-01 |
| 468 | Randomized Clinical Trial to Evaluate The Efficacy of A Digital Intervention for Patients With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to perform a digital intervention in patients with type 2 diabetes to analyze the efficacy of the digital intervention Adhera® Fatigue Digital Program in order to improve diabetes self-management and improve clinical outcomes, including chronic condition-related fatigue. This will be done through a randomized clinical trial in 3 of the main health centers in the city of Xalapa, Veracruz, … |
MARIA DEL CARMEN GOGEASCOECHEA TREJO; | 2023-07-01 |
| 469 | Comparison With Observational Methods and Performance Assessment From Real-life Experience of Closed-Loop Insulin Delivery Systems PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare glycemic control obtained under closed loop depending on the system : Smartguard (Medtronic 780) versus Control IQ (Tandem) in patients with diabetes type 1. |
CORALIE AMADOU; | 2023-07-01 |
| 470 | Awareness of Osteoporosis in Diabetes Mellitus Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoporosis is a condition that describes compromised skeletal microarchitecture in general, with clinical signs of decreased bone mineral density. Diabetes mellitus patients are at increased risk for developing osteoporosis. Identifying whether multiple sclerosis patients have information and awareness about this disease is crucial. This study is aimed to investigate awareness and knowledge of osteoporosis in diabetes mellitus patients. |
MUSTAFA HÜSEYIN TEMEL; | 2023-07-01 |
| 471 | The Effect of Home Midwifery Care Given to Pregnant Women Diagnosed With Gestational Diabetes on Attitudes and Self-Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Since gestational diabetes carries the risk of serious complications for the mother and fetus, it is very important to follow up the pregnancy carefully and consciously. Home follow-up and prenatal care of these pregnant women, whose outpatient follow-up is continued without hospitalization, gains great importance. This study was planned as a randomized controlled experimental study to determine the effects of home midwifery care based on the continuous midwifery care model for pregnant women diagnosed with gestational diabetes, on the attitudes and self-care of pregnant women. The universe of this research, … |
CEMILE ONAT KOROGLU; | 2023-07-01 |
| 472 | Noninvasive Characterization of Tissue Changes in Diabetes in Adults and Children Using Multispectral Optoacoustic Tomography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, blood flow and tissue changes in adult and pediatric patients with diabetes mellitus will be characterized by MSOT and compared with existing methods (ABI testing, neurological testing) (method comparison). The aim is to quantify changes and to possibly allow early detection of concomitant diseases. This could, similar to peripheral arterial occlusive disease, lead to a new possibility of non-invasive assessment of disease progression in the future. |
UNIVERSITY OF ERLANGEN NÜRNBERG MEDICAL SCHOOL | 2023-07-01 |
| 473 | Timing of Resistance Exercise, Glucose Control and Exercise Adaptations in People With Type 1 Diabetes: A Randomised-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aims of the current study are 1. to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes. 2. to compare the effects of morning and afternoon resistance exercise training on cardiometabolic health outcomes in people with type 1 diabetes |
EBAA AL OZAIRI; | 2023-07-01 |
| 474 | Sepsis in ICU: Causes and Outcomes in Diabetics and Non Diabetics in Assiut University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Identify prevalence of sepsis in ICU of Assiut university hospital 2.Clarify different causes of sepsis in patients admitted to ICU . 3.Compare causes and outcomes of sepsis between diabetics versus non diabetics . 4.Screening for the co1.mmonest organism causing sepsis in critically ill patients . |
MAI AHMED FATHI MANSOUR; | 2023-07-01 |
| 475 | Physicians Committee for Responsible Medicine, A Randomized, Crossover Trial of The Effect of A Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the effects of a low-fat, plant-based dietary intervention and a portion-controlled dietary intervention (compliant with current American Diabetes Association (ADA) guidelines) on changes in intramyocellular and hepatocellular lipid content in adults with type 2 diabetes. Changes in insulin sensitivity and glycemic control will also be assessed in this study. The study duration is 44 weeks. |
HANA KAHLEOVA; | 2023-07-01 |
| 476 | INHALE-3: A 17-Week Randomized Trial and A 13-Week Extension, Evaluating The Efficacy and Safety of Inhaled Insulin (Afrezza) Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: INHALE-3 is a Phase 4, randomized controlled trial (RCT) that will randomly assign participants ≥18 years of age with type 1 diabetes (T1D) using multiple daily injections (MDI), an automated insulin delivery (AID) system, or a pump without automation, and continuous glucose monitoring (CGM) 1:1 to an insulin regimen of insulin degludec plus inhaled insulin (Afrezza) and CGM or continuation of usual care. The primary outcome of the RCT is at 17 weeks. The RCT will be followed by a 13-week extension phase in which participants in both groups will use the degludec-inhaled insulin regimen. |
KEVIN CORDONIZ; | 2023-06-29 |
| 477 | A Clinical Study Evaluating The Use Od Ursodeoxycholic Acid As Adjuvant Therapy in Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus (DM) is a complex metabolic disorder characterized by hyperglycemia and abnormalities in carbohydrate, fat, and protein metabolism. It is one of the most prevalent metabolic disorders globally. Despite the advancement in anti-diabetic drug therapy, most patients fail to achieve optimal glycemic control. therefore, there is a large unmet need to develop new strategies to improve the therapeutic outcomes in diabetic patients. This study is designed to evaluate the efficacy of ursodeoxycholic acid as adjunctive therapy in patients with type 2 diabetes mellitus. |
EMAN GHONAIM; | 2023-06-28 |
| 478 | Examining The Feasibility of Prolonged Ketone Concentrate Supplement Drink Consumption in Adults With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Brief Summary: Ketones are a source of energy and signaling molecule that are produced by the body when not consuming any food or consistently eating a low-carbohydrate keto diet. Blood ketones can be used as a source of energy by the body, but they may also act as signals that impact how different cells in the body function. Recently, … |
JONATHAN LITTLE; | 2023-06-26 |
| 479 | The Effects of Preoperative Carbohydrate Loading on Perioperative Blood Glucose Levels and Insulin Resistance in Type 2 Diabetes Mellitus Patients Undergoing Elective Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn the effects of preoperative carbohydrate loading on perioperative blood glucose levels and insulin resistance in type 2 diabetes mellitus undergo elective surgery. The main questions it aims to answer are: – Does carbohydrate loading affects perioperative blood glucose and insulin resistance in type 2 diabetes mellitus patients undergo surgery? – How are the incident of perioperative hyperglycemia and hypoglycemia between subjects who receive placebo compared with subjects who receive carbohydrate loading – … |
ARIES PERDANA; | 2023-06-22 |
| 480 | Feasibility of Kanasina Gulabi, A Pilot Peer Support Intervention for Young Adults With Type 2 Diabetes in Mysore District, South India PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate a pilot peer support intervention, entitled Kanasina Gulabi (Translation My Dream Rose in Kannada), designed to improve quality of life and diabetes management among young adults living with type 2 diabetes. The intervention, delivered by non-specialist providers – trained young adult peer navigators who are also managing type 2 diabetes – is expected to improve physical and mental health outcomes among participants. The sample includes young adults aged 18-40 with a diagnosis of type 2 diabetes in Mysore district, … |
EVE S PUFFER; | 2023-06-21 |
| 481 | An Evaluation of Eat Well, A Produce Benefit, for Patients With Diabetes and At-risk for Food Insecurity PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the impact of participation in Eat Well for diabetes patients who are at risk of food insecurity. The main questions it aims to answer are: * whether there is a difference in Haemoglobin (Hb) A1c measurements and emergency department (ED) utilization between the Eat Well and control groups up to 18 months post-program completion. * whether there are differences in cardiometabolic health-related outcomes for Eat Well participants. Participants in the program will receive gift/debit cards for fruits and vegetables and educational nutrition materials. Researchers will compare Eat Well participants with those only receiving educational materials to see if there are differences in cardiometabolic health outcomes. |
DUKE UNIVERSITY | 2023-06-20 |
| 482 | An Observational Study of Adults With Type 2 Diabetes Using The Community-Derived Open-Source Automated Insulin Delivery Loop System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: An observational study to collect data on the efficacy, safety, usability, and quality of life/psychosocial effects of the community-derived OS-AID Loop System on adults with type 2 diabetes. |
COLLEEN BAUZA; | 2023-06-20 |
| 483 | The Impact of Oral Glutathione on Oxidative Damage and Glycated Hemoglobin (HbA1c) Levels in Type 2 Diabetes Patients: A Randomized, Double-Blind, Placebo-Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial aims to assess the effectiveness of L-glutathione, supplemented with bioavailability boosters (tannin, low molecular weight chitosan, and polyethylene glycol), on improving antioxidant levels and glycemic control in patients with type 2 diabetes (T2D). The study is designed as a randomized, double-blind, placebo-controlled trial intending to enroll 240 T2D patients. The primary objective is to measure changes from baseline to 180 days in several key biomarkers, including endogenous reduced glutathione (GSH), oxidized glutathione (GSSG), 8-hydroxydeoxyguanosine (8-OHdG), and glycated hemoglobin (HbA1c), … |
S LAB SOLOWAYS | 2023-06-20 |
| 484 | Glucagon Enhanced Insulin Absorption in Diabetes Mellitus Type 1 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will study the effect of microdoses of glucagon at the site of subcutaneous insulin injection. The investigators have unpublished data from anesthetized pigs indicating a major enhancement of insulin absorption. |
SVEN M CARLSEN; | 2023-06-20 |
| 485 | Comparison of Histamine and Local Heating for Evoking The Axon-reflex Flare Response in Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetic peripheral neuropathy is the most common complication to diabetes mellitus affecting as much as 50% of the population with diabetes. Symmetrical sensory neuropathy is by far the most common pattern, which often progress slowly over many years, although some individuals experience faster and more severe courses. Despite the frequent occurrence, the causes of diabetic peripheral neuropathy are largely unknown, which is reflected in the fact that no disease-modifying treatments are available for preventing, treating or even halting the progression of the disease. The consequences can be dire, as neuropathy frequently leads to foot ulcers, … |
JOHAN BOVBJERG RØIKJER; | 2023-06-17 |
| 486 | A First in Human, Single Center, Single Dose, Randomized, Placebo-controlled, Dose, Escalating Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneously Administered ENT-03S for The Treatment of Obesity and Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Single center, single-dose, randomized, placebo-controlled, dose-escalating study to evaluate, safety, tolerability, pharmacokinetics, and pharmacodynamics of escalating doses of ENT-03S in obese but otherwise healthy subjects and in subjects with obesity and Type 2 diabetes. |
ENTERIN | 2023-06-13 |
| 487 | Evaluation of The Association Between Depression and Glycemic Control in People With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Single-center prospective observational pilot study The aim of the study is to evaluate the potential association between the percentage of time spent in the optimal glycemia range and the score obtained in the questionnaires used to screen for depression. The study involves only one visit for each participant. Each participant will be asked to sign the informed consent to the study and, during the visit, the following information will be acquired: parameters, history of diabetes, concomitant diseases and medications, and CGM metrics. The participant will be administered the following questionnaires for the evaluation of depression, … |
FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS | 2023-06-12 |
| 488 | The Effect of Education Given to Diabetes Patients According to The Planned Behavior Theory on Patient Empowerment and Self-Efficacy: A Single-Blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is essential to manage the disease to prevent and reduce complications and mortality in patients with diabetes. Adequate information and options should be provided to patients by healthcare providers so that patients can make informed choices. Patient education is a patient empowerment process designed to enable patients to be responsible for their health. With this study, it is considered essential to educate diabetic patients according to the theory of planned behavior and to develop self-efficacy by contributing to patient empowerment in this way. |
SAKARYA UNIVERSITY | 2023-06-12 |
| 489 | A Phase 1, Randomized, Placebo-Controlled, 2-Period, Cross-over, Double- Blind, Single-Dose Study to Evaluate The Effects of LY3532226 on Insulin- Induced Hypoglycemia in Participants With Type 1 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the response of glucagon to insulin-induced low blood sugar after administration of the study drug LY3532226 in participants with type 1 diabetes mellitus (T1DM). The study will also evaluate if LY3532226 helped participants to recover from insulin-induced low blood sugar condition compared to placebo. The study will last approximately 16 weeks excluding screening period. |
VICTORIA MIRZA; | 2023-06-12 |
| 490 | Evaluation of Some Biochemical Markers of Bone Turnover in Childern and Adolescents With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 1 diabetes is associated with many longterm complications as retinopathy,neuropathy and nephropathy. Recently, several studies have linked type 1 diabetes to bone fragility.Studies conducted on patients with type 1 diabetes have concluded that bone is negatively affected in type 1 diabetes with impaired bone density,increased fracture risk and impaired bone turnover markers. |
HAGER MOMEN ISMAIL; | 2023-06-10 |
| 491 | Efficacy of Glucagon-like Peptide-1 Receptor Agonists According to Type 2 Diabetes Subtypes: An Italian Monocentric Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational retrospective study is to understand whether glucagon-like peptide-1 receptor agonists (GLP-1RA), which are a group of antidiabetes drugs, may act differently in different subtypes of patients with type 2 diabetes. The main questions it aims to answer are: – people with type 2 diabetes belonging to specific subtypes respond better (or worse) to GLP-1RA? – the beneficial effect of GLP-1RA may last longer in people with type 2 diabetes belonging to specific subtypes? – … |
FRANCESCO GIORGINO; | 2023-06-10 |
| 492 | Evaluating The Clinical Impact of A PCP Developed Diabetes Education Mobile Web Application on Patients With Uncontrolled Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the use and effectiveness of a mobile web application (app) that is designed to educate and allow patients to manage diabetes and make sustainable lifestyle changes, … |
LUIS MURILLO; | 2023-06-10 |
| 493 | Combined Effects of Balance Training With Moderate Intensity Aerobic Versus Resisted Training on Glycemic Control, Cardiorespiratory Fitness , and Quality of Life in Patients With Type 2 Diabetes Milletus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized control trail will be conducted at Social Security Teaching Hospital, Multan Road, Lahore. Social Security Teaching Hospital Shah rah, Lahore. Non -probability Convenient Random Sampling Technique will be applied on patients who will be allocated through simple random sampling into group A and group B. Group A received moderate intensity aerobic exercises which include walking, cycling, with each session lasting 15 minutes for 3-5 days per week in combination with balance training which include heel raise, standing march with 10 repetitions each for 3-5 days per week. Group B receive moderate intensity resistance exercises which include biceps curls, … |
RIPHAH INTERNATIONAL UNIVERSITY | 2023-06-10 |
| 494 | Short-term Impact of A Low Carbohydrate/High Unsaturated Fat Diet on Hepatic Transcriptomics and Lipidomics in Individuals With Pre-diabetes – A Pilot Study Related Papers Related Patents Related Grants Related Experts View Highlight: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, affecting 25% to 30% of the global population and nearly one third of the population in North America. NAFLD is defined as an excessive accumulation of lipids within hepatocytes in the absence of significant alcohol consumption or other causes of chronic liver disease. These patients usually present with hepatic steatosis observed on imaging studies and elevated liver enzymes with clinical features of insulin resistance (IR), including pre-diabetes, type 2 diabetes mellitus (T2DM), arterial hypertension, dyslipidemia, … |
PATRICK COUTURE; | 2023-06-09 |
| 495 | The Effect of Peripheral Protective Sensation on Peripheral Muscle Strength, Functional Capacity, Balance and Physical Activity Level in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of our study was to investigate the effect of sole sensation on peripheral muscle strength, functional capacity, balance and physical activity level in individuals with Type 2 Diabetes Mellitus. |
MELIS USUL; | 2023-06-06 |
| 496 | A Phase 3, Randomized, Double-Blind Study to Investigate The Efficacy and Safety of Once-Daily Oral LY3502970 Compared With Placebo in Adult Participants With Obesity or Overweight and Type 2 Diabetes (ATTAIN-2) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the safety and efficacy of once daily oral treatment with orforglipron compared with placebo on body weight in adult participants with obesity or overweight and type 2 diabetes. The study will last about 77 weeks and may include up to 22 visits. |
ELI LILLY | 2023-06-05 |
| 497 | How Type I Diabetes Responds to Different Diets (Normoglucidic or Ketogenic) During Physical Activity at Altitude Related Papers Related Patents Related Grants Related Experts View Highlight: To date, no study has shown the effects of diets (normoglucidic or ketogenic) on type I diabetes during physical activity (hiking, ski touring) at altitude. The ketogenic diet in the general population is increasingly studied scientifically, but no clinical trial has studied it in type I diabetic patients during physical activity at altitude. Similarly, no study has investigated the effects of this diet on ketone and blood glucose levels in athletes during physical activity at altitude. Therefore, … |
MAXIME MOULIN; | 2023-06-02 |
| 498 | Title: Closed-loop Medtronic 780G System in Youth With Type 1 Diabetes: AWeSoMe Study Group Prospective Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to describe data on Israeli children and youth using the 780G system including data regarding glycemic control parameters, various questionnaires, sleep data, bioimpedance measures, and dietary parameters. The main questions it aims to answer are: • whether the 780G system will improve glycemic control • whether the psychosocial aspects will improve. Participants will be followed once connected to 780G, at baseline, one, three, and six months after the connection. |
NOAH GRUBER; | 2023-06-01 |
| 499 | Dando Pasos Juntos: An Integrative Group Program for Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open, randomized, controlled trial to determine the impact of an integrative group program on metabolic control and wellbeing perception of patients with T2DM. The integrative group program consists of 6 in-person sessions directed by a health coach and occurring every other week, and 6 asynchronous educative sessions during a period of 12 weeks. |
TANIA ZERTUCHE; | 2023-06-01 |
| 500 | Identifying Barriers to and OptiMizing In-hosPitaL UsE of Evidenced-based Medical ThErapies for PatieNTs With Cardio-Renal-Metabolic Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be a prospective randomized implementation trial for patients hospitalized with heart failure, chronic kidney disease, and/or type 2 diabetes mellitus within Duke University Medical Center. The primary hypothesis is that a virtual quality improvement-based consult intervention will improve the rate of in-hospital evidence-based cardio-renal-metabolic medication use, particularly SGLT2 inhibitor therapy. Approximately 200 patients meeting eligibility criteria will be included in the study. Patients will be assigned into study groups, as defined by randomization of their treating clinician team to receiving the virtual consult versus not. |
STEPHEN J GREENE; | 2023-06-01 |