Clinical Digest: Recent Clinical Trials on Epilepsy
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Epilepsy. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Epilepsy
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Vagal Autonomic Stimulation Physiotherapy (With Trigger Point Release) As An Adjunct to Personalized Antihypertensive Management of Gestational Hypertension Syndrome and Preeclampsia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Preeclampsia is one of the most common and serious complications of pregnancy, affecting both the mother and baby. It is a condition characterized by high blood pressure and can lead to severe complications, including neurological issues and reduced blood flow to the placenta. Preeclampsia is responsible for a significant number of maternal and perinatal deaths worldwide, with an estimated 14% of maternal mortality in Mexico linked to this condition. Recent research suggests that disruptions in the body’s autonomic nervous system, specifically the balance between the sympathetic and parasympathetic systems, play a role in the development of preeclampsia. The vagus nerve, … |
CARLOS ALBERTO GARCIA BECERRA; | 2025-05-01 |
| 2 | SONATA: Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through A Web-based Music Application PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, placebo-controlled, double-blinded randomized study of self-administered auditory intervention in a naturalistic home environment. |
BRIAN FIDALI; | 2025-05-01 |
| 3 | Epilepsy Cycles Longitudinal Monitoring to Inform Personalized Seizure-risk Estimation, A Double-blinded Study of Seizure Forecasting and Randomized Information Withdrawal in Adults With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The occurrence of seizures in epilepsy is not entirely random. Temporal patterns that organize the occurrence of seizures over weeks and months were previously unraveled using intracranial EEG System (IEEG) that monitors epileptic brain activity chronically. Seizures typically recur with patient-specific periodicity and are preceded by increases of epileptic brain activity over days. Here, the investigators developed new methods to forecast seizure likelihoods at a 24-h horizon. In this trial, participants will be provided with daily estimates about their upcoming risk of seizures. As a primary outcome, … |
INSEL GRUPPE AG UNIVERSITY HOSPITAL BERN | 2025-05-01 |
| 4 | REVEAL – Research Evaluating Vagal Excitation and Anatomical Linkages Gastric Emptying Ancillary Project: Effect of Vagal Nerve Stimulation on Gastric Motor Functions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to the same caloric meal before and three months after activation of left cervical VNS. Our hypothesis is that cervical VNS increases gastric accommodation and accelerates gastric emptying. |
MICHAEL CAMILLERI; | 2025-05-01 |
| 5 | Personalized Risk Assessment of Seizures Sensitive to Poor Sleep: A Longitudinal Study Using Wearable Electroencephalography Devices PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy, a prevalent neurological disorder, affects 40% of patients with uncontrolled seizures despite medications. Sleep disturbance exacerbates epilepsy, and vice versa, but existing literature suffers from limitations. Studies conducted in hospital settings provide only brief observation periods and fail to capture the natural sleep environment. Wearable technology offers a promising solution, providing a nuanced understanding of the relationship between seizures and sleep. The Dreem headband, an EEG-based wearable, is well-suited for such studies, offering ease of use and validated accuracy. This technology enables extended observation periods under stable medication conditions, … |
BIRGIT FRAUSCHER; | 2025-05-01 |
| 6 | Prevalence and Pattern of Comorbid Headache in Pediatric Epilepsy Patients Attending Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine the prevalence and characteristics of headaches in children with epilepsy, aged 5-18 years. Approximately 60 children will participate at Assiut University Children’s Hospital. The research will involve medical history collection, physical and neurological exams, EEG review, and blood tests. The study seeks to improve understanding of the relationship between epilepsy and headaches in children, potentially leading to better treatment strategies. Participation is voluntary, and the risks are minimal. |
SOMIA RASHEED ABDELRASOUL; | 2025-05-01 |
| 7 | Cross-Stroke Therapy Effects With BCI and FES Stimulation: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this neurorehabilitation explorative study is to investigate how a closed-loop Brain-Computer Interface Functional Electrical Stimulation (BCI-FES) therapy, used within the intended purpose for hand rehabilitation, may impact swallowing difficulties (dysphagia) and language disorders (aphasia) in post-stroke patients. |
MICHAEL KNOFLACH; | 2025-05-01 |
| 8 | Alleviating Panretinal Photocoagulation Associated Ocular Pain With Vibratory Stimulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if Vibration Anesthesia Device works to reduce pain during retinal laser for diabetic retinopathy. The main question it aims to answer is: Does the Vibration Anesthesia Device reduces the pain felt by patients during the laser treatment? Researchers will compare the standard method (no vibration device) to the standard method with the Vibration Anesthesia Device to see if the device works to reduce discomfort during treatment. Eligible participants will have both eyes treated as required, … |
MATTHEW TENNANT; | 2025-04-28 |
| 9 | Arterial Spin Label Assessment of Cerebral Blood Flow in Anesthetized Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Children undergoing magnetic resonance imaging (MRI) of the brain often need to be sedated to complete the examination, as it is difficult to remain still for a long period, which is required to obtain usable images. During sedation, most patients typically experience a drop in blood pressure, including children. Maintaining an adequate blood pressure under anesthesia is important, as blood pressure is routinely used as a measure to ensure sufficient blood circulation to the body’s organs, including the brain. Ensuring adequate blood flow to the brain is one of the cornerstones of all anesthesia, including in children. Therefore, … |
JACOB KARLSSON; | 2025-04-15 |
| 10 | Trial Readiness and Endpoint Assessment in Pediatric Myotonic Dystrophy Extension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a natural history study to improve the types of assessments and biological samples that will be used in clinical drug trials in both congenital myotonic dystrophy and childhood myotonic dystrophy. |
NICHOLAS JOHNSON; | 2025-04-14 |
| 11 | The Effect of Dual-tasking Program on Cognitive and Physical Functions and Independence in Activities of Daily Living in Children with Duchenne Muscular Dystrophy: A Single-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and frequent developmental, cognitive and behavioral impairments, occurring in one in 5000 live births of boys. DMD is caused by a deficiency of the protein dystrophin, which maintains the structure and functionality of muscle cells. The absence of dystrophin leads to the weakening and eventual death of muscle cells, resulting in reduced muscle strength and impaired motor function. In early childhood, children with DMD may experience delays in basic motor skills such as walking and standing. Later in life, … |
BAŞAK ÇAĞLA ARSLAN; | 2025-04-14 |
| 12 | CorEvitas Inflammatory Bowel Disease Pregnancy Registry (IBD-PR) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Data collected through the registry may be used to address a range of research questions and objectives, including but not limited to the following: Research question: Is there an increased risk of adverse maternal, fetal, or infant outcomes among individuals who are exposed to Inflammatory Bowel Disease (IBD) treatments during pregnancy? The primary objective of the registry is to estimate the prevalence of major congenital malformations among pregnant individuals with IBD who are exposed to an IBD pharmacotherapy during pregnancy. The secondary objectives of the registry are: To estimate the prevalence of other maternal, fetal, … |
RONNA L CHAN; | 2025-04-01 |
| 13 | A Multicenter Randomized Clinical Trial to Assess The Clinical Efficacy and Cost-effectiveness of Bevacizumab Versus Corticosteroids As First-line Treatment in Patients with Symptomatic Cerebral Radiation Necrosis After Radiation for High Grade Glioma or Brain Metastases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral radiation necrosis (CRN) is a severe complication of high-dose radiation for brain metastases (BM) or glioma, which can potentially cause significant neurologic symptoms leading to serious morbidity and impaired quality of life (QoL). The first-line therapy for symptomatic CRN (sCRN) is corticosteroids, primarily dexamethasone, which often leads to complications, refractory symptoms, and interference with anti-cancer treatment. Since 2017, bevacizumab, an antibody against Vascular Endothelial Growth Factor (VEGF), … |
DIETA BRANDSMA; | 2025-04-01 |
| 14 | Prevalence of Neurodevelopmental Disorders in A Homeless Population – Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction \& Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder). Methods / approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, … |
CAROLINE DEMILY; | 2025-04-01 |
| 15 | In Vitro Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cannabis, in addition to its psychotropic properties, could have anti-inflammatory and immunomodulatory effects. Phytocannabinoids (pCBs) are a group of molecules naturally secreted by the cannabis plant. The major pCBs are cannabidiol (CBD) and Δ9-tetrahydrocannabinol Δ9 (THC). Only THC has psychotropic effects, which CBD does not have. Alongside these two main components, there is a wide variety of other molecules, such as other pCBs and terpenes which could increase the effects on immune system through synergistic interactions between these different compounds (entourage effect).In vivo, pCBs essentially interfere with the endocannabinoid system, acting on many ubiquitous receptors, … |
CARINE PR SALLIOT; | 2025-04-01 |
| 16 | Shared Subcortical Arousal Systems Across Perceptual Modalities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a multi-site study and will be conducted at up to 11 investigative sites in the United States. The study will investigate subcortical arousal circuits in visual perception using techniques with complementary strengths based on promising initial studies. |
HAL BLUMENFELD; | 2025-04-01 |
| 17 | The Research on The Role of Human Chorionic Gonadotropin (HCG) Activation in Vivo on The Dormant Follicles in Patients With Premature Ovarian Insufficiency (POI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to activate dormant follicles in patients with premature ovarian insufficiency by injecting human chorionic gonadotropin (hCG) to explore the feasibility of a treatment plan that stimulates the growth of dormant follicles, not visible to the naked eye, to antral follicles visible under ultrasound, without visible follicle growth. The project also seeks to enable patients to conceive offspring carrying their own genetic material through in vitro fertilization (IVF) technology. |
XIAO CHEN; | 2025-04-01 |
| 18 | CAMSAN: Cognitive Augmentation Via Multimodal Sensing and Auricular Neurostimulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to extend this period of optimal cognitive performance by applying neurostimulation to buffer health volunteers against the effects of increased levels of stress, distraction, and cybersickness. The main questions it aims to answer are: * Can we use OpenBCI’s head-mounted Galea biosensor + eXtended Reality (XR) platform to measure participants’ cognitive state in relation to stress, attention and cybersickness? * How does applying external neurostimulation via Spark Biomedical’s Sparrow Link transcutaneous auricular neurostimulation (tAN) system enhance cognitive performance with a closed-loop interface that automatically applies neurostimulation as a function of physiologically determined stress, … |
MUSA MAHMOOD; | 2025-04-01 |
| 19 | Ferumoxytol Enhanced Hippocampal Vascular Imaging in Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, … |
DONALD GROSS; | 2025-03-31 |
| 20 | Long Term Efficacy and Safety of Transcranial Magnetic Stimulation Targeting Cerebellum to Treat Drug-resistant Epilepsy During Enhanced and Maintenance Phase PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to observe the long term efficacy and safety of cerebellar continuous θ burst stimulation (cTBS) for drug-resistant Epilepsy during enhanced and maintenance phase，in order to provide a new treatment for long-term control of drug-resistant epilepsy and improve the quality of life of those patients. A total of 100 patients with DRE will undergo cTBS treatment by precise navigation to bilateral cerebellar dentate nuclei. The frequency and clinical feature of seizures, scalp EEG，clinical score, MOCA，MMSE，and QOLIE-31 were ssessed at baseline, after 2 weeks of enhanced phase，8 weeks of consolidate phase, and 8 weeks of maintenance phase. |
XIJING HOSPITAL | 2025-03-28 |
| 21 | The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Aim: Carbon monoxide (CO) poisoning is a significant public health issue that can cause delayed neuropsychological sequelae (DNS). DNS mechanisms involve oxidative stress, inflammation, and immune injury. Although hyperbaric oxygen therapy is widely used, … |
CHINA MEDICAL UNIVERSITY HOSPITAL | 2025-03-23 |
| 22 | Study on The Effectiveness and Safety of Temporal Interference Stimulation in Treating Patients with Severe Consciousness Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigating the efficacy and safety of temporal interference stimulation for patients with disorders of consciousness. |
XUEHAI WU; | 2025-03-20 |
| 23 | Investigation of Postural Parameters, Physical Functions, Balance and Quality of Life in Different Hip Pathologies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is known that pelvic parameters affect physical hip functions in hip pathologies. Depending on the type and severity of hip pathologies, posture, muscle strength, balance, and pain parameters may change, thereby impacting an individual’s quality of life. This study aimed to examine the postural parameters, muscle strength, balance, quality of life, pain intensity, and pain localization of individuals with different hip pathologies, including hip osteoarthritis, hip impingement syndrome, hip labrum tear, hip dysplasia, and hip avascular necrosis. |
ESRA ATEŞ NUMANOĞLU; | 2025-03-20 |
| 24 | Child Bipolar Network Ketogenic Diet Approach to Bipolar Disorder in Adolescents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study is an open trial of ketogenic diets for adolescents and young adults (ages 12-21 yrs) in the depressive or mixed phases of bipolar disorder (BD). The investigators aim to determine whether combining standard of care pharmacological treatment for bipolar spectrum disorders with a 16-week ketogenic diet is well-tolerated and associated with improvements in depression, inflammatory and metabolic indicators, and executive functioning over the study period. The experimental treatment in this study is a 16-week full ketogenic diet. Four study sites (UCLA, U Cincinnati, … |
DAVID J. MIKLOWITZ; | 2025-03-19 |
| 25 | Cartography of Social Cognition Network and Their Alterations in Patients with Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Social cognition, which refers to the ability to interpret social information and behave accordingly in a social environment, is crucial in everyday life. But this ability has been shown to be altered in patients with epilepsy, especially in medial temporal lobe epilepsy, which leads to a deterioration in the patient’s quality of life. However, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-03-19 |
| 26 | Effects of Treadmill Training With and Without Compression Stockings on Toe Walking and Balance in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) affects around 1.7% of US children, with co-occurring conditions like ADHD, anxiety, and epilepsy complicating daily functioning. Early intervention strategies, such as sensory-based therapies and physical exercises like treadmill training, are used to improve motor skills and overall functioning in children with ASD. A randomized controlled trial is being conducted to evaluate the impact of treadmill interventions on children with toe-walking behaviors. Participants will be assigned to either Group A or Group B, … |
QUTBIA ABAQ JAVED CHEEMA; | 2025-03-15 |
| 27 | Randomized Phase 2 Study of Valproic Acid Combined with Rechallenge Anti-EGFR Based Regimen Regimens in Pretreated Patients with RAS/BRAF Wild-type Metastatic Colorectal Cancer – VICTORIA Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators hypothesize that the epigenetic agent valproic acid improve the activity of anti-EGFR agents, prevent and revert the emergence of EGFR resistance, in a rechallenge setting. Correlative mechanistic studies on tissue and blood samples, liquid biopsies, could identify potential biomarkers of efficacy and help understanding the evolutionary dynamics of tumors in response to therapy thus optimizing the treatment approach with a personalized anti- EGFR treatment strategy. |
NATIONAL CANCER INSTITUTE NAPLES | 2025-03-01 |
| 28 | Safety and Efficacy of Ventricular Irrigation for Ventriculitis: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Ventriculitis is a severe infectious disease of the central nervous system with diverse etiologies. Currently, the treatment for ventriculitis is challenging, with poor prognosis. The mortality rate of ventriculitis is generally reported to be higher than 30%, with the highest reaching over 75%. Even among survivors, over 60% suffer from a variety of neurological sequelae, including cognitive impairment, gait disturbances, paralysis, behavioral disorders, and epilepsy. Currently, treatments for ventriculitis recommended by guidelines primarily focus on the selection and administration of antibiotics, while the effects of surgical interventions have not been fully elucidated. In recent years, … |
JIYAO JIANG; | 2025-03-01 |
| 29 | Optical Imaging As A Diagnostic Tool for Monitoring Brain Function in X-linked Rare Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fragile X syndrome (FXS, OMIM #300624) and Creatine Transporter Deficiency (CTD, #300352) are the two most common causes of X-linked intellectual disability. FXS and CTD affect hemizygous males and with highly variable severity heterozygous females. Both these neurodevelopmental disorders (NDDs) have a dramatic impact on the family quality of life and the health-care system. These disorders share common clinical traits, including intellectual disability, autistic-like features, behavioural and mood alterations and seizures. Brain anatomy appears largely normal, suggesting that functional deficits result from subtle changes in synaptic connectivity. Moreover, … |
HOSPICES CIVILS DE LYON | 2025-03-01 |
| 30 | Sensory Perception in Children With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a chronic neurological disorder characterized by abnormal neuronal activity, affecting approximately 0.5-1% of children worldwide. It has significant social, psychological, and physical consequences, leading to impairments in cognitive, motor, and behavioral functions. Sensory processing disorders (SPDs) further contribute to these challenges, affecting children’s ability to regulate and interpret sensory information, which impacts learning, daily functioning, and emotional regulation. SPDs are categorized into sensory modulation disorder, sensory-based motor disorder, and sensory discrimination disorder. Dunn’s sensory processing model identifies four sensory profiles: low registration, sensory seeking, sensory sensitivity, and sensory avoidance. Sensory modulation disorders, including sensory over-responsivity, under-responsivity, … |
SEDA AYAZ TAŞ; | 2025-03-01 |
| 31 | Spatial Memory and Temporal Lobe Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Temporal lobe epilepsy (TLE) can cause memory disorders, including long-term forgetfulness due to a failure to consolidate verbal but also spatial information. The forgetting phenomenon presented by these epileptic patients is called accelerated forgetting in the literature and remains difficult to objectify during cognitive assessments. It is indeed particularly complicated to evaluate long-term spatial memory and to account for the topographical complaint, although recurrent, of patients with this TLE. A navigation task being proposed as part of the neuropsychological assessment of patients with a spatial memory complaint, … |
CENTRE HOSPITALIER METROPOLE SAVOIE | 2025-03-01 |
| 32 | Implementation and Cost Evaluation of Project UPLIFT PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study tests Project Using Practice and Learning to Increase Favorable Thoughts (UPLIFT) which is a Mindfulness-based Cognitive Behavioral Therapy program teaching participants with epilepsy methods that include challenging thoughts, behavioral activation, coping, problem-solving, and mindfulness, for well-being and costs. Project UPLIFT is delivered as weekly sessions over 8 weeks. |
NGOC CAM ESCOFFERY; | 2025-03-01 |
| 33 | Effect of Motor Planning Exercises Versus Neurodevelopmental Technique on Gait Pattern in Children with Spastic Diplegic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral palsy is the most common disability in childhood, is a devastating non-progressive ailment of the infants’ brain with lifelong sequelae (e.g., spastic paresis, chronic pain, inability to walk, intellectual disability, behavioral disorders) for which there is no cure at present. Cerebral palsy has different causes such as perinatal asphyxia, stroke and central nervous system CNS infection. Cerebral palsy may have several associated comorbidities, including epilepsy, musculoskeletal problems, intellectual disability, feeding difficulties, visual abnormalities, hearing abnormalities, and communication difficulties. There are different classifications of CP primarily based on motor type and topography one of them is diplegic CP, … |
AHMED MOHAMED ELSAYED SHARAF; | 2025-03-01 |
| 34 | A Multicenter Pilot Clinical Trial to Prevent Infantile Spasms Relapse PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After initially successful treatment, many children with infantile spasms unfortunately have a relapse, and relapse is linked to poor long-term outcomes such as autism and other forms of epilepsy. The aim of this study is to determine if treatment with low-dose prednisolone is safe, well tolerated, and effective in reducing the risk of relapse. |
SHAUN HUSSAIN; | 2025-03-01 |
| 35 | Sensory Modulation in Children With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a neurological condition that can impact cognitive, motor, and behavioral skills, often leading to sensory modulation disorders (SMDs) in children. These disorders impair sensory processing, affecting daily functioning and quality of life. This study aims to explore the sensory profiles of children with epilepsy and identify sensory modulation disorders. The study will include 34 participants: 17 children with epilepsy and 17 healthy controls, aged 3-10 years. Inclusion criteria include at least one seizure in the past year, a diagnosis of epilepsy, and voluntary participation. Children with comorbid conditions such as cerebral palsy, autism, genetic disorders, … |
SEDA AYAZ TAŞ; | 2025-03-01 |
| 36 | Clinical Research on Umbilical Cord Mesenchymal Stem Cells Therapy for Patients with Subacute Intracerebral Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intracerebral hemorrhage (ICH) is a common condition with high morbidity, mortality, and disability. The current treatments for ICH primarily include surgical and pharmacological interventions. For large hematomas, surgical options such as craniotomy, debridement, decompression, and minimally invasive hematoma aspiration may be performed. Pharmacological treatments are mainly symptomatic. Despite timely and standardized surgical or pharmacological interventions, many patients with ICH still experience significant sequelae, which severely affect their quality of life and place a substantial burden on both families and society. Currently, there are limited drugs available specifically for the treatment of ICH. In recent years, … |
TANG ZHOUPING; | 2025-03-01 |
| 37 | Efficacy and Safety of Percutaneous Foramen Ovale Closure in Adult Patients with Drug-resistant Epilepsy and Patent Foramen Ovale: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patent foramen ovale (PFO) is the most common cause of right-to-left shunt (RLS) in the adult heart, with a prevalence of approximately 25% in the general population. Extensive research has demonstrated an association between PFO and neurological conditions such as cryptogenic stroke, migraine, and sleep apnea syndrome, and it is even considered a potential root cause of these disorders. However, the mechanisms by which PFO contributes to neurological diseases remain unclear. In our preliminary clinical work, we have observed a strong correlation between PFO and epilepsy, … |
BO ZHANG; | 2025-02-28 |
| 38 | Insights Into The Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Neurovascular uncoupling (NVU) represents a major source of potential bias for the identification of eloquent brain regions through activation procedures in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Same region shows proper pattern in glucose metabolism in victiny of brain lesions, investigated with positron emitted tomography with radiolabeled glucose (PET-FDG) This research project aims at investigating the mechanisms of NVU by using a multimodal noninvasive imaging approach in neurosurgical patients. |
ERASME UNIVERSITY HOSPITAL | 2025-02-17 |
| 39 | EFFECTS OF BALNEOTHERAPY IN BREAST CANCER PATIENTS UNDERGOING ENDOCRINE THERAPY PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Endocrine therapy is the mainstay of adjuvant therapy in premenopausal women with hormone receptive-positive (HR+) breast cancer as it has been demonstrated that it reduces long-term recurrences and increases survivial. However, this therapy, which suppresses estrogen production and estrogen-induced effects, is associated with the development of joint pain which can significantly reduce quality of life and lead to treatment discontinuation. The main question the study aims o answer is: Can balneotherapy (BT) alleviate muscle-skeletal pain (primary objective) derived from endocrine therapy and improve quality of life (secondary objective) in young women with HR+ breast cancer? |
NATALIA GARCIA GIRALT; | 2025-02-10 |
| 40 | Sleep Architecture & Cognition in Focal Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Focal Epilepsy (FE) patients and healthy controls will wear an actigraph at home for one week and a home sleep study device at home for one night. Participants will then undergo two nights of testing (at least one week apart) at California Sleep Solutions (CSS) in Sacramento, CA. During the overnight stays, participants will have EEG leads placed and possibly a headband. They will undergo cognitive testing before they go to sleep and again in the morning. During one night of testing, sounds will be played in the room (acoustic stimulation). The sounds should not wake the participants. |
UNIVERSITY OF CALIFORNIA DAVIS | 2025-02-01 |
| 41 | The Effect of Epilepsy Management At School Mobile Health Application on Epilepsy Knowledge, Attitudes, and Self-Management of Teachers of Children with Intellectual Disability: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to determine the effects of the training given to the teachers of children with intellectual disabilities with the Epilepsy Management at School Mobile Health Application and the Digital Epilepsy Education Guide on teachers’ epilepsy knowledge, attitudes, and self management levels. This study was planned in a pretest, posttest design, follow-up, randomized controlled study. The sample of the study will consist of 90 teachers. Intervention-1 (Epilepsy Management at School Mobile Health Application, n=30), intervention-2 (Digital Epilepsy Education Guide, n=30) and control group (group without any intervention, … |
ZAHIDE İYİ ALTINIŞIK; | 2025-02-01 |
| 42 | Capturing Autobiographical Memory Formation in People Moving Through Real-World Spaces Using Synchronized Wearables and Intracranial Recordings of EEG PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main questions it aims to answer are: How does the brain encode and retrieve real-world autobiographical memories? Can multimodal data integration enhance our understanding of memory-related cognitive and neural mechanisms? Participants will: * Use a smartphone-based recording application (CAPTURE app) to collect real-world data. * Have their wearable sensor data (e.g., audio-visual, accelerometry, GPS, autonomic physiology, … |
CORY INMAN; | 2025-01-30 |
| 43 | SIMPLIF-AI: SIMPLIFication and Standardization of Care Pathways for Patients with Rare Brain Tumors Through Artificial Intelligence PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study focuses on rare brain tumors, which are heterogeneous entities with different morphological, biological, and clinical characteristics. Due to their rarity, many of these tumors fall under the RARECARE definition of rare tumors. The main objective of the study is to standardize care models and pathways for patients with rare brain tumors, using Artificial Intelligence (AI) and Machine Learning (ML) techniques to identify specific predictors of postoperative outcomes. The study includes both retrospective and prospective phases, with the collection of clinical, cognitive, … |
PAOLO FERROLI; | 2025-01-27 |
| 44 | EPI-NY: Improving Diagnostics and Care After First Seizure PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A first epileptic seizure is a distressing experience, often leading to a complicated and discouraging journey before an epilepsy diagnosis is confirmed. Early diagnostics can help alleviate this uncertainty. It is important to note that seizure mimics and suspected epilepsy are more frequently encountered than an actual first diagnosis of epilepsy or an epileptic seizure. Conversely, delays in diagnosing epilepsy are also common. The current evidence base on first events that may be epileptic remains limited. First seizure clinics, which provide specialized care for these cases, are becoming more common globally, … |
JAN BROGGER; | 2025-01-24 |
| 45 | Study on The Safety, Tolerability, and Preliminary Efficacy of Single Intrathecal Injection of AAV-MECP2 for The Treatment of Rett Syndrome Related Papers Related Patents Related Grants Related Experts View Highlight: Rett syndrome (RTT) is a serious neurodevelopmental disorder that has a significant impact on patients and their families. Patients suffer from severe social dysfunction and poor quality of life, and there is currently no effective treatment available. The MECP2 functional loss mutation is the clear pathogenic factor. In recent years, gene therapy has been applied in neuromuscular diseases such as SMA and has achieved good safety and effectiveness. Professor Qiu Zilong’s self-developed AAV-MECP2 gene therapy product for RTT was found to significantly improve disease symptoms in RTT model mice, … |
GUANGZHOU WOMEN AND CHILDREN’S MEDICAL CENTER | 2025-01-14 |
| 46 | Safety and Efficacy of Prophylactic Tranexamic Acid in Reducing Postpartum Hemorrhage After Cesarean Delivery in Women with Systemic Autoimmune Disease：A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women. Systemic autoimmune diseases are associated with adverse pregnancy outcomes (APOs), including PPH, preeclampsia, thromboembolism, abortion, and intrauterine growth restriction. The incidence of PPH in women with systemic lupus erythematosus has been reported to be as high as 34%. Prevention of PPH is the key to reduce complications in high-risk women. In recent years, a large number of clinical studies have confirmed that the early preventive use of tranexamic acid(TXA) can reduce the amount of blood loss, the need for additional uterine contraction agents, … |
RENJI HOSPITAL | 2025-01-06 |
| 47 | Multicentre, Randomized, Controlled Clinical Trial on 7-day Followed By Maintenance Therapy for 10 Weeks Vs. 14-day and No Maintenance Course of Prednisolone for The Treatment of Infantile Epileptic Spasms Syndrome (IESS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if short courses (7 days) of oral prednisolone are as effective as longer courses (14 days) in treating Infantile Epileptic Spasms Syndrome (IESS) in infants. The main questions it aims to answer are: 1. Does a 7-day course of oral prednisolone result in a similar or better reduction in spasm frequency compared to a 14-day course? 2. Does the duration of treatment (7 vs. 14 days) influence relapse rates and developmental outcomes in infants with IESS? 3. Researchers will compare the effects of the two treatment arms (7-day course vs. 14-day course of oral prednisolone) to see if there is a difference in efficacy and safety. Participants will: 1. Receive either a 7-day or 14-day course of oral prednisolone as part of their treatment 2. Be monitored for spasm frequency and any side effects during hospital observation for the first 48 hours 3. Maintain a spasm diary during the treatment period to track spasm frequency 4. Return for follow-up visits at 7 days, 14 days, 28 days, 42 days, 3 months, 6 months, and 12 months to assess treatment response, relapse, and developmental outcomes |
JITHANGI WANIGASINGHE; | 2025-01-01 |
| 48 | Predict to Prevent PGRN Disease Related Papers Related Patents Related Grants Related Experts View Highlight: Progranulin (GRN or PGRN) mutations are among the most common genetic causes of frontotemporal lobar degeneration (FTLD). With the advent of gene-specific therapeutic interventions, an accurate knowledge of the presymptomatic phase of the disease is of utmost importance. Increases of plasma neurofilament light chain (NfL) levels are good predictors of phenoconversion in presymptomatic carriers. However their increase rates remain partially elucidated insofar, with many confounding factors. Another point which deserves further precision is the definition of the biological onset of the disease, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-01-01 |
| 49 | A Pilot Study to Evaluate The Feasibility and Safety of Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a non-randomized, open label, phase 1 clinical trial to evaluate the fesibility and safety of intrathalamic delivery of MSCs during standard of care DBS surgery for epilepsy. Subjects will be screened at our outpatient clinic and interested qualified subjects will be consented and offered participation in this trial. Once consent has been obtained, patients will undergo a standard preoperative evaluation which includes baseline laboratory values and a high-definition MRI. Patients will then undergo a stereotactic procedure for bilateral thalamic implantation of DBS leads through the ClearPoint® system. After the thalamic target for DBS is identified, … |
SANJEET S. GREWAL; | 2024-12-23 |
| 50 | Retrospective Evaluation of Cenobamate’s Health Care Resources Utilization (HCRU) in The Management of Uncontrolled Focal Onset Seizures- A Retrospective, Chart Review Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Study is an observational, retrospective study which aim is to assess cenobamate’s healthcare resources utilization (HCRU) in the management of uncontrolled focal onset seizures. The amin objective is to compare the resource utilization before and after the use of cenobamate. Data from medical charts will be used and inserted into the eCRF from which the analyses will be conducted. Data from 200 patients from 10 sites in 5 countries are included. |
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S P A | 2024-12-19 |
| 51 | Comparison of The Effect of Low Glycemic Index Diet Compared to The Classical Ketogenic Diet in Reducing The Number of Seizures in Children with Drug Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a common disease among children. Today, treating epilepsy remains a major challenge, with many children affected by this condition. According to reports, 30% of children with epilepsy do not respond well to treatment. Various methods are available for managing epilepsy, one of the most accepted therapies for this condition are dietary therapies. Numerous studies have shown that dietary therapy is an effective and can have reasonable response in treating seizure. The most commonly used dietary intervention is the Classic Ketogenic Diet (CKD). In the CKD, approximately 90% of calories come from fat, … |
SAMAN SEPEHRAR; | 2024-12-05 |
| 52 | Neuroarchitectural Recovery Model of Post-stroke Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The societal burden of stroke patients with persistent neurological deficit is high. It is therefore imperative that the mechanisms of rehabilitation-induced motor recovery be better understood in the hopes of developing more efficacious rehabilitative therapy. The treatment outcomes of people with stroke after rehabilitation vary, with up to 60% of people having residual impairment of the upper limb function. The high variability in rehabilitation-induced recovery prompted researchers and clinicians to develop more efficacious rehabilitative interventions for functional regain in post-stroke patients. However, … |
SAI KAM HUI; | 2024-12-01 |
| 53 | Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the feasibility and acceptability of an online group Neuro-behavioral Therapy (NBT) with text messaging intervention for Veterans with epilepsy and major depressive disorder (MDD). |
MELISSA FADIPE; | 2024-11-21 |
| 54 | A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Temporal Lobe Epilepsy (MTLE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, single arm, open label clinical trial that is designed to test the safety and preliminary efficacy of single administration inhibitory nerve cells called interneurons (NRTX-1001), into both temporal lobes of subjects with drug-resistant bilateral mesial temporal lobe epilepsy. |
NEURONA THERAPEUTICS | 2024-11-14 |
| 55 | Epilepsy Journey 2.0: An Intervention to Improve Executive Functioning in Adolescents With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this multi-site clinical trial is to determine the effectiveness of two components of a web-based intervention (Epilepsy Journey) to improve executive functioning in adolescents with epilepsy. The two components include web-based modules and problem-solving telehealth sessions with a therapist focused on executive functioning. This trial aims to answer the following questions: 1. Which components of Epilepsy Journey (web-based modules or telehealth sessions with a therapist) are essential for improving executive functioning in adolescents with epilepsy? 2. Which components of Epilepsy Journey (web-based modules or telehealth sessions with a therapist) are essential for improving quality of life in adolescents with epilepsy? Participants will be randomly assigned to one of four groups: 1) Epilepsy Journey web-based modules and telehealth sessions, 2) Epilepsy Journey web-based modules only, 3) telehealth sessions with a therapist only, or 4) treatment as usual. Participants will: * Independently review Epilepsy Journey web-based modules focused on executive functioning skills (\~15-30 minutes) and/or have weekly telehealth sessions (\~30-45 minutes) with a therapist for 14 weeks. * Complete measures of executive functioning (parent and teen-report) and quality of life (teen-report) at the start of the study, 14-, 26-, and 66- weeks after randomization. The NIH toolbox will be completed at the start of the study and 26-weeks after randomization. Additional measures will also be collected. |
AVANI MODI; | 2024-11-11 |
| 56 | Evaluation of Sustained Endogenous Attention Deficits in Attention Deficit Hyperactivity Disorder: Validation of A Computerized Neuropsychological Test. PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Subjects with ADHD may exhibit deficits in sustained internal attention. The Sustained-Paced Finger Tapping test was recently developed and experimentally used in international literature to assess sustained internal attention in typically developing children. This clinical study has several objectives: 1) to assess the presence of internal sustained attention deficits in children with ADHD through the Sustained-Paced Finger Tapping; 2) to evaluate the discriminant and ecological validity of the Sustained-Paced Finger Tapping. |
IRCCS EUGENIO MEDEA | 2024-11-11 |
| 57 | A Randomized Controlled Trial Investigating The Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective double blind phase II study seeks to evaluate the safety and efficacy of BRC-003, a high CBD investigational product, in the treatment of refractory PTE (Post-Traumatic Epilepsy). The research is divided into two phases: an open-label dose-finding phase (Part A) and a subsequent randomized controlled phase (Part B). This design aims to provide a thorough understanding of the investigational product’s impact on seizure frequency, seizure severity, mood, anxiety, sleep, and quality of life. |
PAUL LYONS; | 2024-11-01 |
| 58 | Lemborexant Treatment of Insomnia Linked to Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess whether Lemborexant can improve sleep in patients with epilepsy. |
UNIVERSITY OF MANITOBA | 2024-10-29 |
| 59 | Taiwan Post-Stroke Disability Study (T-PODS): A Survey of Multiple Post-Stroke Disability Domains Among Stroke Patients in Taiwan PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke remains a major health issue in Taiwan, being the fourth leading cause of death and the top cause of disability. While past research has focused on functional outcomes at three months post-stroke, stroke can cause a range of disabilities in areas such as motor function, swallowing, cognition, depression, and epilepsy. This study will investigate these disabilities by enrolling 2,000 acute stroke patients (both ischemic and hemorrhagic) from 10 medical centers across Taiwan. Data will be collected at three key points: at enrollment, three months, and twelve months post-stroke, using surveys, assessments, imaging, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2024-10-21 |
| 60 | Investigation of The Effects of Transcutaneous Vagus Nerve Stimulation on Fibromyalgia. A Double Blind, Sham-controlled Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stimulation of the vagus nerve, a parasympathetic nerve that controls the digestive, the vascular and immune systems, produces pain relief in various clinical conditions. Transmission via vagal afferents to the nucleus of the solitary tract has been proposed as the primary physiological mechanism that reduces pain intensity following vagal stimulation. Medication is one of the pillars of dealing with chronic pain, with several benefits, but also side effects. Fibromyalgia is an idiopathic chronic pain syndrome with few, effective and safe treatments. However, … |
MARTINA REKATSINA; | 2024-10-15 |
| 61 | Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cenobamate (YKP3089) is a small molecule approved in the United States (US), Europe and several other countries around the world for the treatment of Partial-Onset (focal) seizures in adult subjects (≥18 years of age). In the US it is approved for use as monotherapy, however, there is little clinical data assessing its use as monotherapy in adults with POS. This study is designed to explore the effectiveness of doses of 100 mg/day and 200 mg/day as monotherapy in adult subjects with newly diagnosed or recurrent POS/focal onset epilepsy. |
REBECCA JONES; | 2024-10-14 |
| 62 | A Phase 2A, Multicenter, Open-label Study Evaluating The Safety and Efficacy of RAP-219 in Adult Participants With Refractory Focal Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a clinical research study for an investigational drug called RAP-219 in patients with Refractory Focal Epilepsy. This study is being conducted to determine if RAP-219 works and is safe in patients with Refractory Focal Epilepsy. |
JAQUELINE A FRENCH; | 2024-10-10 |
| 63 | The Effects of Cognitive Behavioral Play Intervention on The Quality of Life of Children With Childhood-onset Epileptic Syndromes. PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the effectiveness of Cognitive Behavioral Play Therapy interventions in patients with epilepsy. Children with epilepsy will be randomly assigned to one of two intervention conditions: the experimental group will receive cognitive-behavioral play intervention, while the control group will engage in free play. Assessments will be done at the start (T0) and end (T1) of the intervention, measuring behaviors, coping strategies, positive thinking, problem-solving, and quality of life. |
MARTINA PAOLA P ZANABONI; | 2024-10-07 |
| 64 | Barriers Vs. Resources: A Mechanistic Randomized Clinical Trial Comparing Virtue-Based and Cognitive-Behavioral Interventions in Patients With Chronic Medical Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to analyze the specific and common mechanisms of change of two active treatments, one based on reducing barriers -Cognitive Behavioral Therapy (CBT)- and the other based on enhance resources -Virtue-Based Intervention (VBI)- for increasing well-being in patients with chronic medical disease. A mechanistic randomized controlled trial will be conducted with two experimental conditions (CBT and VBI) and four evaluation points (pre- and post-intervention and 6- and 12-month follow-up). |
AUSIAS CEBOLLA; | 2024-10-02 |
| 65 | Investigation of The Effects of Associated Impairments in School-Age Children With Cerebral Palsy on The Child’s Activity and Participation Level and on Their Families PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the effects of associated impairments on the activity levels and social participation of school-aged children with Cerebral Palsy (aged 6-12) and their impact on their families’ quality of life and caregiving burden. |
ESRA ERDINLER; | 2024-10-01 |
| 66 | Comparison of Oxcarbazepine Versus Carbamazepine in The Management of Trigeminal Neuralgia in Patients Presenting in Outpatient Department of Neurology in Jinnah Postgraduate Medical Centre PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Trigeminal neuralgia is a debilitating neurological condition, affecting quality of life in most affected patients. Carbamazepine has traditionally been used for the management of this condition, but it has a moderate effectiveness and a poor side-effect profile. Oxcarbazepine is more tolerable, and has a more favorable side-effect profile. This study aims to compare the effectiveness of oxcarbazepine and carbamazepine in the management of this condition, for improved prescription practices in the future. |
RIZWANA MALAHAT AHMAD; | 2024-09-21 |
| 67 | Investigating The Effect of Different Frequencies of Transcranial Electrical Stimulations Paired With Cognitive Training on The Executive Brain Functions in Dementia Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dementia is a prevalent condition with no known cure. It affects not only the person with dementia but also the family. This study will investigate the effects of applying different transcranial electrical stimulation (tES) waveforms to find the optimal stimulation when paired with cognitive exercise on older adults with dementia. It is a placebo-controlled double-blind study with statistical rigor. In addition, the investigators will investigate technological methods to monitor changes due to the intervention. These include functional near infrared spectroscopy (fNIRS), electroencephalography (EEG), electrovestibulography (EVestG), … |
UNIVERSITY OF MANITOBA | 2024-09-20 |
| 68 | High-resolution Multi-parametric Magnetic Resonance Imaging for Focal Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with focal epilepsy often have diagnostic difficulties as their culprit for seizures are difficult to be picked up using conventional imaging. The current study is to investigate the utility of advanced MRI sequences on detection of subtle lesions accountable for focal epilepsy. |
LEUNG HO SANG; | 2024-09-01 |
| 69 | Exploration and Evaluation of Amygdalo-Hippocampectomy According to Prof. Coubes’ Technique: An Anatomical, Clinical, and Educational Approach PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this retrospective study is to evaluate the long-term clinical outcomes and complications associated with amygdalo-hippocampectomy using the surgical technique developed by Pr. Coubes (Montpellier, FRANCE). The main questions it aims to answer are: * What are the complications and evolution of clinical outcomes in patients treated with this technique for hippocampal sclerosis or other intern temporal diseases ? * What variables are associated with better seizure control following surgery? Participants include 234 patients treated over the last 30 years at the CHU de Montpellier, FRANCE. The study will analyze clinical data, … |
PIERRE-OLIVIER MOSER; | 2024-08-31 |
| 70 | Study to Understand The Diagnostic Measures, Management Options and Long Term Outcomes in A Local Cohort of Patients with Electrical Status Epilepticus in Sleep, Also Known As A Developmental And/or Epileptic Encephalopathy with Spike-Wave Activation in Sleep PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our aims are: 1. To understand the diagnostic practices, treatment and long term management and outcomes for patients diagnosed with ESES locally. 2. To establish a regional and national guideline for the diagnosis and management of patients with ESES. The secondary questions that can be addressed with this case series review include the variability of clinical care given to patients with this condition, and for example, the duration of time it takes to obtain diagnostic tests and assessments by psychologists. |
EAST SUFFOLK AND NORTH ESSEX NHS FOUNDATION TRUST | 2024-08-12 |
| 71 | Effects of Cuevas Medek Exercises on Trunk Control and Balance in Children With Down Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Down syndrome, a genetic condition caused by the presence of an extra copy of chromosome 21. This additional genetic material affects the normal development of the brain and body, leading to intellectual and developmental delays. Individuals with Down syndrome often have distinctive physical features, such as a flat facial profile, almond-shaped eyes, and a short neck. Down syndrome has three types include Trisomy 21 (95% cases, extra chromosome 21), Translocation (3-4%, extra part attached), and Mosaic (1-2%, mixture of normal and trisomic cells). Children with Down syndrome often face challenges in motor development, … |
HAFIZA SARA WAFA; | 2024-08-10 |
| 72 | Natural History with Focus on Oncological Risk Evaluation in Pediatric Patients with PTEN Pathogenic Variants – Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study in pediatric patientis carryng PTEN pathogenic variants aimed to define oncological risk in children and provide a deeper insight of the clinical course, establishing an updated follow-up protocol. |
FONDAZIONE I R C C S ISTITUTO NEUROLOGICO CARLO BESTA | 2024-08-01 |
| 73 | A Randomized, Open-Label, 4-Way Crossover, Pharmacokinetic Study to Compare CBD-NE to Epidyolex in Healthy Adult Volunteers Under Both Fed and Fasted Conditions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cannabidiol (CBD), derived from the Cannabis sativa plant, is being investigated for its potential health benefit without the psychoactive properties and adverse reactions that arise from the use of delta-9-tetrahydrocannabinol (Δ9-THC). Few studies have characterized the pharmacokinetic (PK) effects and safety of oral CBD administration. Epidiolex (Epidyolex), an oil form of CBD, … |
ANTHONY BIER; | 2024-08-01 |
| 74 | A Phase 2, Global, Multicenter, Long-term Safety Study Designed to Assess The Safety and Tolerability of BHV-7000 in Subjects With Refractory Focal Onset Epilepsy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A study to determine if BHV- 7000 is safe and tolerable in adults with refractory focal onset epilepsy |
BIOHAVEN THERAPEUTICS | 2024-07-30 |
| 75 | The Effect of Dual Task on Postural Control in Children Diagnosed with Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An individual’s postural control is often accompanied by other tasks in daily life, such as cognitive tasks. Cognitive dual task (cognitive dual task) is the ability to perform two or more cognitive and motor activities simultaneously. There are studies in the literature that address the postural control of different patient populations and healthy individuals while performing a cognitive task. To our knowledge, there is no study evaluating the postural control skills of children with epilepsy during a cognitive dual task using dynamic posturography (Biodex). In this respect, … |
DENIZ TUNCER; | 2024-07-26 |
| 76 | Characterisation of Skin Microstructure Under Normal and Atrophied States PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Skin dermatoses are a major health concern around the world, with heavy economic, social, and psychological burdens. Due to their chronic and incurable nature, they are serious diseases that cause physical pain in patients and reduced quality of life. Atopic dermatitis is the most common inflammatory skin disease with a prevalence of almost 20% in children and 10% in adults. Current therapies are designed to control the condition rather than cure it. Therefore, these therapies are lifelong and, when the disease is flaring, must be used intensively to achieve control. Despite the emergence of various therapies, … |
MICHAEL J CORK; | 2024-07-16 |
| 77 | A PHASE 1, OPEN-LABEL, RANDOMIZED, SINGLE-DOSE, 2-WAY CROSSOVER, PIVOTAL BIOEQUIVALENCE STUDY COMPARING 50-MG CHEWABLE DILANTIN® INFATABS® MANUFACTURED AT VEGA BAJA (PUERTO RICO) AND ASCOLI (ITALY) IN HEALTHY ADULT PARTICIPANTS UNDER FASTING CONDITIONS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to understand how the different formulation of phenytoin is taken up into the blood in Healthy Adults. This study is seeking healthy adult participants. All the study participants will receive Phenytoin 50 mg chewable tablets manufactured at Ascoli and Vega Baja manufacturing site. We will measure how the phenytoin will be taken up into the blood in Healthy Adults following oral dosing of Phenytoin. This will help us determine if the Phenytoin 50 mg chewable tablets manufactured at Ascoli and Vega Baja manufacturing site are similar or not. |
PFIZER | 2024-07-16 |
| 78 | Effects of A Very Low Carbohydrate Ketogenic Diet Versus Mediterranean Diet on Markers of Bone Health and Muscle Function in Older Adults: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Preclinical data indicate that very low carbohydrate ketogenic diets (KD) may prevent progression of age-related sarcopenia (skeletal muscle decline) but also may disturb bone metabolism. The investigators will pilot test a randomized trial comparing the effects of short-term adaptation to a well-formulated ketogenic diet and Mediterranean diet on markers of bone metabolism and muscle function in older adults. The expected results will help inform the benefit-risk assessment for older patients considering longer term use of KD therapy. |
CORA BEST; | 2024-07-15 |
| 79 | A MULTICENTER, OPEN-LABEL, SINGLE-ARM STUDY TO EVALUATE LONG-TERM SAFETY AND TOLERABILITY OF BRIVARACETAM IN STUDY PARTICIPANTS WITH CHILDHOOD ABSENCE EPILEPSY OR JUVENILE ABSENCE EPILEPSY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to investigate the long-term safety and tolerability of brivaracetam in study participants with childhood absence epilepsy or juvenile absence epilepsy. |
UCB BIOPHARMA SRL | 2024-07-10 |
| 80 | A Phase 2/3 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety, and Tolerability of BHV-7000 As Adjunctive Therapy in Subjects With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures, With Open-label Extension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether BHV-7000 is effective in the treatment of idiopathic generalized epilepsy with generalized tonic-clonic seizures and includes an additional open-label extension (OLE) phase. |
BIOHAVEN THERAPEUTICS | 2024-06-20 |
| 81 | Additional Effects of Functional Muscle Training With Turning Based Specific Training During Turning in Post Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is the leading cause of disability leading to Gait and balance dysfunction leading to decreased Quality of Life. Difficulty in turning is a major target in Gait Rehabilitation. Task specific exercises has proven to be effective in all stages of stroke rehabilitation, therefore Turning based specific training is to be used in order to improve turning and balance in post stroke patients moreover functional strength training of lower extremities prove to be more effective than traditional training. |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-06-20 |
| 82 | Exploring The Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Using Multimodal Imaging Techniques: A Prospective Observational Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Using multimodal imaging technology, this study aims to explore the characteristics of epileptogenic foci in patients with drug-resistant epilepsy and identify key network nodes (such as central nodes) to provide more assistance for the diagnosis of drug-resistant epilepsy. |
XIJING HOSPITAL | 2024-06-11 |
| 83 | A Study on The Efficacy and Mechanism of Targeted Cerebellar Transcranial Electrical Stimulation for The Treatment of Refractory Temporal Lobe Epilepsy: A Single-center, Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study the therapeutic effect and potential neural mechanisms of transcranial electrical stimulation targeting the cerebellum for the treatment of refractory temporal lobe epilepsy through MRI and EEG. |
XIJING HOSPITAL | 2024-06-08 |
| 84 | .An Open-label Clinical Trial Evaluating The ExAblate Model 4000 Type-1 Focused Ultrasound Unilateral Thalamotomy for Patients with Treatment-refractory Focal Onset Epilepsy and Comorbid Anxiety PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the feasibility, safety, and effects on anxiety of high intensity focused ultrasound ablation (FUSA) in patients suffering from treatment-refractory focal epilepsy and anxiety. FUSA is a non-invasive neurosurgical procedure that uses ultrasound waves, sent directly through the scalp and skull, to precisely target small abnormal areas of the brain. For this study, the targeted area of the brain is the anterior nucleus of the thalamus. This brain region may cause seizures and may also be involved in anxiety. The study will test if FUSA is safe and tolerated, … |
TIMOTHY LUCAS; | 2024-06-04 |
| 85 | Beyond Watching and Waiting: A Pilot Study of A Novel Social Emotional Learning Curriculum-Based Intervention Designed for Youth With Epilepsy at Increased Risk of Future Mental Illness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Youth with epilepsy (YWE) are significantly more likely than their peers without epilepsy to experience isolation, interpersonal victimization, and low relationship satisfaction. This is a serious health concern. Poor social support, real or perceived, is consistently correlated to worsened outcomes in every domain of health-related quality of life. As YWE are two to five times more likely than their peers without epilepsy to develop a mental health condition, poor social support is likely a bidirectional risk factor. Currently, … |
LAURIE DOUGLASS; | 2024-06-01 |
| 86 | Italian Cp EArly REhabilitation (iCARE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study aims to investigate the efficacy of play-based rehabilitation delivered as usual care in children with cerebral palsy in a rehabilitation center offering both intensive and extensive care. Up to now, few studies described and examined treatments’ efficacy in this population. Secondary aim of the study will be comparing the efficacy of the two rehabilitation treatment formats (intensive vs. extensive), which will have the same dose (sessions delivered) and ingredients (content). The intervention delivered as extensive care (3 sessions per week per 15 weeks) will be offered in community rehabilitation centers (Centri di Riabilitazione-CDR), … |
SANDRA STRAZZER; | 2024-05-21 |
| 87 | Motor and Sensory Nerve Conduction Studies in Amateur Football, Volleyball and Tennis Athletes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to determine how nerve conduction velocities in the upper and lower extremities of athletes in football, volleyball and tennis branches change. The study was completed with a total of 64 participants in 4 groups, with equal numbers of participants in the groups: football, volleyball and tennis players, and a control group that does not do sports. Nerve conduction studies (ulnar sensory, median motor, tibial motor and sural sensory nerves) with an EMG (electromyography) device were applied to participants in 4 groups. |
UMUT PAKSOY; | 2024-05-15 |
| 88 | Validation of A Clinical Complications Scale (CCS) in Patients with Disorders of Consciousness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The clinical condition of severe cognitive-motor impairment of Disorders of Consciousness (DoC; e.g., Vegetative State – VS, and Minimal Consciousness State – MCS), is characterized by a high risk of developing clinical complications. In this study, the investigators propose a new Clinical Complications Scale (CCS) developed to assess the impact of clinical complications on the long-term evolution of a cohort of patients with DoC. This is a multi-site prospective observational study conducted in patients with Severe Acquired Brain Injury and DoC admitted to six centers of Fondazione Don Gnocchi (Italy), … |
ANNA ESTRANEO; | 2024-05-15 |
| 89 | A Phase 2/3 Multicenter, Randomization, Double-Blind, Placebo-Controlled, Study to Evaluate The Efficacy, Safety and Tolerability of BHV-7000 in Subjects With Refractory Focal Onset Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy. |
BIOHAVEN THERAPEUTICS | 2024-05-13 |
| 90 | The Effect of The Training Programme Based on The Health Promotion Model Given to Parents of Children Diagnosed With Epilepsy on Disease Management: A Randomised Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomised controlled study evaluates the effect of a training programme based on the Health Promotion Model developed for parents of children diagnosed with epilepsy on parents’ level of knowledge about epilepsy, parents’ general self-efficacy level, parents’ health promoting and protective behaviours and the number of hospital admissions of their children. The hypothesis of this study is that education has an effect on these. |
SÜMERYA YASTI; | 2024-05-13 |
| 91 | Assessing The Impact of Brief Cognitive Behavioural Therapy for Insomnia on Sleep Difficulties in A Dissociative Seizure Population, Using A Single-Case Experimental Design Related Papers Related Patents Related Grants Related Experts View Highlight: Some people experience a temporary change in behaviour and consciousness, that often involves a collapse and/or shaking limb movements. These are referred to as ‘Dissociative seizures’. Those who experience such seizures have been found to also display high levels of dissociation, … |
SARAH ADAM; | 2024-05-06 |
| 92 | The Effect of RehaCom Computer-Assisted Rehabilitation Program on Self-Management, Cognitive Function and Quality of Life in Epilepsy Patients: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the effects of the RehaCom Computer-Assisted Rehabilitation Program Applied to Epilepsy Patients on Self-Management, Cognitive Function and Quality of Life. |
ÜLKÜ SAYGILI; | 2024-04-26 |
| 93 | Investigation of The Relationship Between Trunk Somatosensory Function, Trunk Control, and Thoracic Kyphosis in Children With Spastic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational study aims to investigate the relationship between trunk somatosensory function, trunk control, and thoracic kyphosis in children with cerebral palsy. The main questions it seeks to answer are: – Is there a relationship between trunk somatosensory function and trunk control? – Is there a relationship between trunk somatosensory function and thoracic kyphosis? – Is there a relationship between trunk control and thoracic kyphosis? |
GULCE KALLEM SEYYAR; | 2024-04-22 |
| 94 | Investigation of Incidence Rate of Post-stroke Seizure and Post-stroke Epilepsy in Patients Under Treatment With Alteplase and Correlated Factors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This retrospective cohort study was conducted by reviewing the records of consecutive patients referred to Bu Ali Sina Hospital from 2016 to 2023, who were hospitalized with a diagnosis of ischemic stroke. The records of all patients treated with intravenous alteplase during the above period were extracted, and the relevant characteristics were recorded in a questionnaire. In each year, patients with ischemic stroke who were not treated with alteplase but were hospitalized at the Bu Ali Center were selected in a similar number to patients who received alteplase in the same year, … |
NASIM TABRIZI; | 2024-04-14 |
| 95 | Effects of Hand Arm Bimanual Intensive Therapy Including Lower Extremity on Balance and Coordination in Ataxic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ataxic cerebral palsy is an abnormal movement or posture pattern accompanied by a loss of coordinated muscle action, resulting in movements that lack proper force, rhythm, or accuracy. Ataxic CP is classified into cerebellar ataxia and ataxic diplegia. In Cerebellar Ataxia, the cerebellum is hypo-plastic or malformed which impairs the integration of brain signals required for coordinating coordinated movement and balance. This study aimed to determine the effect of HABIT-ILE on the balance and coordination of children with cerebellar ataxic cerebral palsy. |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-04-10 |
| 96 | Evaluation of The Use of Video EEG Examination Extended With Intra-auricular Electrodes in The Assessment of Patients With Drug-resistant Temporal Lobe Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to evaluate the effectiveness of long-term video EEG monitoring using 10-20 electrodes extended with intra-auricular electrodes in locating the seizure onset zone and interictal epileptiform discharges (IEDs) in patients with temporal lobe epilepsy (TLE) and nontemporal lobe epilepsy (non-TLE). |
PRZEMYSLAW KUNERT; | 2024-04-08 |
| 97 | Stellate Ganglion Block Combined With Dexmedetomidine or Subanesthetic Ketamine Infusion for Treatment of Neurostorm After Traumatic Brain Injury in Critically Ill Patients: A Randomized Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Neurostorming is a sudden and exaggerated stress response as a result of damage to the brain. With appropriate treatment and time, there is hope for individuals to overcome storming, regain consciousness, and work towards successfully recovering from brain injury. Most treatments for neurostorming involve the use of medications only such as dexmedetomidine, opioids, gabapentin and propofol to address secondary complications like high blood pressure and fever. These medications focus on slowing the body’s stress response or relaxing the body. Stellate ganglion block (SGB) is a promising therapy for paroxysmal sympathetic hyperactivity (PSH), … |
ESLAM S. ALMAGHAWRY MOHAMED; | 2024-04-04 |
| 98 | Assessing Comorbidities in Epilepsy Using Eye Movement Recordings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study wants to make it easier to find kids with a type of epilepsy called childhood absence epilepsy (CAE) who might have problems with ongoing seizures and thinking. Right now, … |
RACHEL KUPERMAN; | 2024-04-01 |
| 99 | Microelectrode Recordings From The Vagus Nerve in Awake Humans PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Anchillary project uses a refined technique of ultrasound-guided microneurography of the human cervical vagus nerve, an approach developed by Professor Vaughan Macefield and used safely to-date in 44 prior study participants. The overall goal of this project is to build upon prior data obtained using this approach by undertaking a detailed neurophysiological investigation of the human vagus nerve and to identify the nerve fibers activated during vagal nerve stimulation (VNS) in participants with implanted VNS devices in response to different stimulation parameters. In addition to providing data in unprecedented detail into the physiology of the human vagus nerve, … |
VAUGHAN G MACEFIELD; | 2024-04-01 |
| 100 | Open Label, Single-Arm Study of The Safety and Tolerability of A Leucine Enriched Essential Amino Acid Powder As An Add-on to A Classic Ketogenic Diet in Refractory Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the safety and tolerability of a Leucine-Enriched Essential Amino Acid (LEAA) Powder as an add-on to a classic ketogenic diet (KD) in pediatric and adult patients with refractory epilepsy. |
ELIZABETH ANNE THIELE; | 2024-04-01 |
| 101 | Targeting The Gut to Improve Seizure Control in CDD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Standard anti-seizure medications have limited efficacy in seizure control in cyclin-dependent kinase-like 5 deficiency disorder (CDD). The study will investigate whether targeting the gut-microbiota-brain axis in CDD patients can alleviate seizures and ameliorate other comorbidities. |
AGLAIA VIGNOLI; | 2024-04-01 |
| 102 | Intraoperative MRI Prone Position Support Frame Design Feasibility Study Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn if the prototype adjustable prone positioning frame is a feasible design for use during neurosurgical procedures which utilize intraoperative magnetic resonance imaging (iMRI). The main questions it aims to answer are: – Is the prototype prone positioning device design feasible for use during neurosurgical procedures which utilize intraoperative MRI? – … |
MICHAEL KINSMAN; | 2024-04-01 |
| 103 | A Multi-site Feasibility Clinical Trial of Retraining and Control Therapy (ReACT), A Mind and Body Treatment for Pediatric Functional Seizures PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the feasibility of conducting a future fully powered multi-site efficacy Randomized Controlled Trial (RCT) comparing two treatments for pediatric functional seizures (FS). In this study, 11-18-year-olds diagnosed with FS will be randomized to 12 sessions of Retraining and Control Therapy (ReACT) or Competent Adulthood Transition with Cognitive Behavioral, Humanistic, and Interpersonal Training (CATCH-IT) at 3 sites: University of Alabama at Birmingham, … |
AARON FOBIAN; | 2024-03-18 |
| 104 | A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate The Efficacy, Safety and Tolerability of BHV-7000 in Subjects With Refractory Focal Onset Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy. |
BIOHAVEN THERAPEUTICS | 2024-03-14 |
| 105 | Retraining and Control Therapy (ReACT): Sense of Control and Catastrophic Symptom Expectations As Targets of A Cognitive Behavioral Treatment for Pediatric Psychogenic Non-epileptic Seizures (PNES) – R33 Phase PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of pediatric psychogenic non-epileptic seizures (PNES, episodes resembling epileptic seizures but with no correlated epileptiform activity). 11-18-year-olds diagnosed with PNES will engage in twelve sessions of either ReACT or supportive therapy. Sense of control over actions will be measured by the magic and turbulence task, … |
AARON FOBIAN; | 2024-03-09 |
| 106 | The Effect of Web-based Education Provided According to The Health Promotion Model on Self – Management in Epilepsy Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a disease that requires long-term treatment and follow-up. Epilepsy To be successful in management, the educational needs of the patient must first be determined and the individual Treatment compliance should be increased by ensuring self-management of the disease.Interventions planned based on the model in patient education direct caregivers to specific goals and provide more planned, coordinated and safe care. The Health Promotion Model (HGM), developed by Nola Pender, is one of the models used to explain health protection and promotion behaviors. It is not aimed at preventing any disease or disability, but aims to improve health, … |
ŞUHEDA ÜSTÜNDAĞ; | 2024-03-01 |
| 107 | The Effect of Lycra Garments on Balance and Respiratory Functions in Spastic Diplegic Cerebral Palsy Patients With Scoliosis: Single-blinded, Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this study was to investigate the effects of lycra clothing on balance and respiratory functions in individuals with cerebral palsy with scoliosis, and the secondary aim was to investigate the effects of lycra clothing on motor function, activity limitation and quality of life in these individuals. |
FATIH ÇELIK; | 2024-03-01 |
| 108 | The Effect of Progressive Relaxation Exercise and Music Recital on Sleep, Quality of Life and Emotional State in Children With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was planned as a randomized controlled experimental study with a pretest-posttest design to determine the effect of parental supervision and video-guided progressive relaxation exercise (PRE) and music recital on sleep, quality of life and emotional states in children with epilepsy aged 9-16 years. The main questions it aims to answer are as follows: According to the evaluation of children with epilepsy, does the progressive relaxation exercise applied to children have an effect on sleep, quality of life and emotional states? According to the evaluation of children with epilepsy, … |
EMRE USTA; | 2024-03-01 |
| 109 | A Randomised Controlled Trial Evaluating The Efficacy and Mechanisms of A Ketogenic Diet As An Adjunctive Treatment for People With Treatment-resistant Depression PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Depression is a debilitating chronic illness affecting 1 in 6 adults in the United Kingdom (UK) at any one time. Antidepressants and psychological therapy are the main treatments, but some people do not respond to these. Neurons and signals in the brain are greatly disrupted in people with severe depression. A ketogenic diet, a high-fat and very low-carbohydrate diet, … |
MIN GAO; | 2024-02-22 |
| 110 | Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to answer the question: what is the effect of Vagal Nerve Stimulation (VNS) dosing on opioid withdrawal responses in individuals with a history of Opioid Use Disorders (OUDs)? Eligible participants will be in the study for one week in an inpatient research hospital stay, have an MRI scan, and have a follow-up call 1-3 months after their inpatient stay. Participants will complete several psychiatric questionnaires/interviews, physiological monitoring with several devices, brain imaging, and VNS testing. |
JAMES DOUGLAS BREMNER; | 2024-02-20 |
| 111 | Effect of Lidocaine, Dexmedetomidine, Esmolol and Magnesium Use on Optic Nerve Sheath Diameter and Hemodynamic Response After Laryngoscopy: Randomized, Controlled, Double-blind Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to compare the effects of lidocaine, dexmedetomidine, esmolol, and magnesium on optic nerve sheath diameter and hemodynamic response to laryngoscopy. The participants will be patients determined to need intubation and general anesthesia for any elective surgery. Each participant will receive either lidocaine, dexmedetomidine, esmolol, magnesium, or none before anesthesia induction, according to randomization. The investigator will measure the optic nerve sheath diameter by ultrasonography before and after intubation. Researchers will compare the difference between optic nerve sheath diameter, systolic blood pressure, … |
BERNA CALISKAN; | 2024-02-14 |
| 112 | Characterization By Automated System on Infantile Spasmes PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Infantile spasms are defined by the occurrence of epileptic episodes characterized by the appearance of very specific motor seizures, made up of rapid, repeated contractions in flexion or extension known as spasms. This syndrome is of high concern as it will lead to mental retardation if it is not early identified and treated. Most often, spasms are characterized by sudden contractions of the body in flexion. More rarely, spasms occur in extension: the neck and legs suddenly tense, and the arms move upwards or sideways. Spasms may be accompanied by eye revulsion. They are brief, … |
JEAN BERGOUNIOUX; | 2024-02-01 |
| 113 | Efficacy Evaluation and Mechanism Study of Ketogenic Diet on Autism Spectrum Disorder in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, which is characterized by social interaction and communication defects, rigid repetitive behaviors, and often accompanied by speech development retardation. According to the report released by the Morbidity and Mortality Weekly Report (MMWR) of the Centers for Disease Control and Prevention (CDC), according to the statistical data analysis in 2020, one out of every 36 8-year-old children (2.76%) was confirmed to have autism spectrum disorder (ASD). This ratio is higher than that published in December 2021, … |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2024-02-01 |
| 114 | The Effect of Respiratory Muscle Performance on Cognitive Functions in Children With Epilepsy: Monitoring With Glymphatic System Activation and Neuropeptides PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy, one of the most common neurological disorders in childhood, is a chronic brain disease characterised by neurobiological, psychological and cognitive effects. Brain-derived neurotrophic factor (BDNF), neuropeptide-Y (NPY) and neural growth factor (NGF) play a role in different pathological processes seen in epileptogenesis. Neuron-specific enolase (NSE), a quantitative indicator of brain damage, has been shown to exhibit elevated serum levels in individuals with epilepsy and this has been associated with cognitive function. In neurological diseases, … |
MIRAY BASER; | 2024-01-24 |
| 115 | Home Ultra-longterm EEG Monitoring for Rare Epilepsies and Developmental and Epileptic Encephalopathies. An Open Label Nonpharmacological Interventional Prospective Study By Means of Minimally Invasive Wearable EEG Device PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: With this study the Investigator expects to develop a precise patient-centered model of care by means of home ultra-long-term EEG monitoring with a minimally invasive wearable EEG device (sqEEG). The following aims will be pursued: 1. to assess the sensitivity, reliability, and safety of sqEEG to record seizures over prolonged periods; 2. to verify sensitivity and reliability of automated seizure detection algorithms and to assess circadian and ultradian seizure/interictal epileptic discharges; distribution for the development of personalized seizure action plan; … |
STEFANO MELETTI; | 2024-01-17 |
| 116 | Celiac Disease Among Egyptian Children With Unexplained Short Stature PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Detect the prevalence of celiac disease in children with unexplained short stature attended at Assiut University Children Hospital. |
ESRAA ATEF SHEHATAA; | 2024-01-15 |
| 117 | Prevalence of Falls and Associated Factors in Haemodialysis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In France, falls among the elderly lead to more than 100,000 hospitalisations and more than 10,000 deaths each year. A French study published in October 2020 highlighted 5 profiles of older people who fall. However, this study is only based on falls of people over 65 years of age that required hospitalisation. In haemodialysis patients, several studies have shown that the incidence of falls ranges from 1.18 to 1.6 falls/patient/year. This population is more likely to be frail, suffer from sarcopenia, have reduced functional capacity and be polymedicated, … |
UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE | 2024-01-01 |
| 118 | EPIVIEWS: Exploring Patient Impact & Value in Epilepsy Wearables for Seizure Monitoring PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study Is to determine the accuracy and reliability of the wearable device in a controlled environment. This study will inform patients, healthcare professionals, and the wider community of the accuracy of the device in detecting seizures. |
ROYAL COLLEGE OF SURGEONS IRELAND | 2024-01-01 |
| 119 | The Effect of A Low Carbohydrate- High Fat Diet on Clinical Symptoms and Gut Microbiome in M.3243A>G Related Mitochondrial Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In daily practice, doctors and dietitians in the clinic receive many questions in general from patients with a Mitochondrial Disease (MD), and more specific whether nutritional changes can alleviate their symptoms. Mitochondrial Inherited Diabetes and Deafness (MIDD) is due to a mitochondrial mutation at the m.3243A>G locus. Nutrition is known to affect disease burden in MIDD. Which diet does this best is unknown. Very low carbohydrate high fat diets improve mitochondrial function in isolated cells and in mice. Whether it does so in people with MIDD is unknown. Therefore, … |
HEIDI ZWEERS- VAN ESSEN; | 2024-01-01 |
| 120 | Examining The Effect of Metaverse-Based Epilepsy Education on Parents’ Epilepsy Knowledge Level: Randomized Controlled Experimental Research PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The research is a randomized controlled experimental study and was planned to examine the effect of metaverse-based epilepsy education on the epilepsy knowledge level of parents. |
MEHMET DURAY; | 2024-01-01 |
| 121 | Cardiac Injury and It’s Relation to Convulsive Status Epilepticus in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Determine the impact of cardiac injury on clinical profile, cardiac evaluation and outcome in patients hospitalized with convulsive status epilepticus (CSE). 2. Analyze the frequency of cardiac rhythm and conduction abnormalities related to seizures and determine risk factors and associated clinical characteristics. 3. Analyse ECG abnormalities and changes in HR in epileptic seizures since such disturbances might be a factor in SUDEP 4. Assessment of levels of cardiac enzymes in patients with status epilepticus |
CHRISTIN EMAD RAGHEB; | 2024-01-01 |
| 122 | Chronic Neck Pain: A Comprehensive Study of The Relationship Between Cognitive Function and Functional Status PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The aim of this study was to investigate the relationship between cognitive function and pain, functional limitations, and cervical muscle endurance in individuals with chronic neck pain (CNP). Methods: The study included 29 individuals (28F, 1M) aged between 18 and 65 years, with non-specific neck pain lasting for at least 3 months, non-neurological symptoms, and no history of head, neck or upper extremity surgery in the last 6 months. Cognitive functions were assessed using the Montreal Cognitive Assessment (MOCA) and Trail Making Test (TMT), pain level using the Visual Analog Scale (VAS) and Bournemouth Neck Pain Questionnaire (BNPQ), … |
T DERE; | 2024-01-01 |
| 123 | Randomized Controlled Trial Evaluating The Impact of Virtual Reality Exposure Therapy on Epilepsy/Seizure-Specific Interictal Anxiety In People With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this randomized control trial is to evaluate the impact of Virtual Reality (VR) Exposure Therapy (ET) on people with epilepsy who experience epilepsy/seizure-specific (ES) interictal anxiety. The main questions it aims to answer are: 1. Can virtual reality exposure therapy (VR-ET) help reduce ES-interictal anxiety in this population? 2. Are the study procedures sufficiently simple for participants to follow? Study Design Summary: – Fourteen (14) participants will be randomized into either an Experimental arm (receiving VR-ET) or Control arm – … |
ESTHER BUI; | 2024-01-01 |
| 124 | Factors Associated With Successful Completion of MRI in Children Undergoing A Vigil Sedation With Dexmedetomidin: An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective cohort study aiming to determine whether the use of Dexmedetomidine (DEX) to sedate children prior to MRI scanning is more or less effective in children with autism spectrum disorders or other neurodevelopmental disorders compared to other children. |
ANNE CHARLOTTE CULLIER; | 2024-01-01 |
| 125 | Psychiatric Comorbidities in Children With Generalized Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is defined as a chronic disorder that presents with recurrent episodes of unprovoked seizures. Epileptic seizures are caused by excessive excitation of cortical neurons. The condition has various etiologies and comorbidities. Classification; The Classification of Epilepsies includes several diagnostic levels (steps): 1. from seizure type to epilepsy type (generalized/focal/combined generalized and focal/unknown) 2. etiology (genetic/ structural/ infectious/ metabolic/ immune/unknown). A clinician can use any level of the classification |
ASMAA GAMAL HASHEM; | 2023-12-30 |
| 126 | Standardized Evaluation of Long-term Neurocognitive Development of Children from Age 3 with Pyridoxine Dependent Epilepsy By Antiquitine Deficiency PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate with the VINELAND II scale the long-term neurocognitive development of children above age 3 years with pyridoxine dependent epilepsy related to antiquitine deficiency. |
PATRICK VAN BOGAERT; | 2023-12-29 |
| 127 | Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: MD-RING will explore the hypothesis that position effects and TAD alterations act as an unprecedented pathomechanism in r(14)S. This will contribute to a better understanding of genotype-to-phenotype correlations, creating an important scientific resource for the study of this and other ring syndromes, with the ultimate objective to offer improved family counseling , patient care and to identify potential new therapeutic options. |
TOMMASO PIPPUCCI; | 2023-12-15 |
| 128 | Dose Study of Tranexamic Acid in Total Hip Replacement to Reduce Post-operative Hemoglobin Loss: A Phase 2 Randomized Double-blind Monocentric Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A single preoperative dose of tranexamic acid (TXA) reduces blood loss and red blood cell transfusion in primary hip arthroplasty. Numerous regimens have been tested, ranging from 10mg/kg up to 3g. However the optimal dose to administer is unknown. |
JULIEN LANOISELEE; | 2023-12-07 |
| 129 | Comparison of Quality of Life and Changes Experienced By Patients After Epilepsy Surgery, With Long-term Epileptological Objective Results PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is one of the most common chronic neurological diseases. According to data from the World Health Organization (WHO), it affects 0.5 to 1% of the population, or around 70 million people world-wide and around 600,000 in France. There are several more or less severe forms of epilepsy depending on the type of epileptic seizures and the frequency of these seizures. About 30% of epileptic patients respond poorly to well-conducted medical treatment, … |
HELENE MIRABEL; | 2023-12-01 |
| 130 | SCN2A, Rs2304016 Polymorphisms Are Associated With Response to Valproic Acid in Paediatric Epilepsy Patients (Pakistan) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this Observational study was to identify the effect of SCN2A gene polymorphism in the Paediatric epileptic Pakistani population. The main question it aims to answer is: to evaluate the effect of this genetic polymorphism on the clinical efficacy of Valproic acid Participants were prescribed Valproic acid after diagnosis of epilepsy. |
SUGHRA KANWAL; | 2023-12-01 |
| 131 | The Effect of A Program Based on The Family-Centered Empowerment Model on Total Knee Prosthesis Patients and Their Caregivers: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the family empowerment model program given to individuals who underwent Total Knee Prosthesis and their caregivers was examined on the individuals’ physiological function level, self-efficacy, and post-discharge hospital readmission (during the follow-up period); It was aimed to determine the effect of caregivers on their care burden, caregiving competence, … |
YASEMIN SARA; | 2023-12-01 |
| 132 | A Mobile Health Application to Detect Absence Seizures Using Hyperventilation and Eye-Movement Recordings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to find out if a smartphone app can identify absence seizures. Children who have a history of absence seizures, as well as children without any seizure history, will be testing out the app. If participating the child will be guided through hyperventilation, an activity that asks the child to take quick, deep breaths. The app will record video of the child’s face and sounds they make during hyperventilation. Hyperventilation is a safe and established technique frequently used during EEG (electroencephalogram) to encourage seizure occurrence. The App will be used during a regularly scheduled EEG. |
RACHEL KUPERMAN; | 2023-12-01 |
| 133 | The Effect of Vibration Therapy and Mirror Therapy on Upper Limb Function in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Due to lack of evidence about the difference between the effects of Vibration Therapy and Mirror Therapy on stroke patients, this study aims at comparing the two, in the context of hemiparesis, to help patients improve hand motor functioning and gain occupational recovery. This study applies a two-arm parallel group randomized trial with 36 participants aged 30-65, who had sub-acute stroke 6 months before the study recruitment, and upper limb function deficits of Brunnstrom stage ≥ 3, the spasticity of affected upper extremity score ≤ 2 on the modified Ashworth scale. The participants are outpatients from Jazan Region, Saudi Arabia, … |
HASSAN SAROR; | 2023-11-27 |
| 134 | Expanded Access Treatment With LP352 for Patients With Developmental and Epileptic Encephalopathies (DEEs) Who Successfully Completed An LP352 Clinical Trial (Intermediate-Size EAP) Related Papers Related Patents Related Grants Related Experts View Highlight: This is an intermediate-size expanded access program (EAP) study. The purpose of this EAP is to provide continued access to LP352, an investigational drug product being investigated in patients with Developmental and Epileptic Encephalopathies (DEEs). The EAP study will allow continued treatment with LP352 for eligible patients diagnosed with treatment resistant DEEs who successfully completed an LP352 Clinical Trial (Enrollment by Invitation). |
LONGBOARD PHARMACEUTICALS | 2023-11-19 |
| 135 | The Effect of Motivational Interviewıng Technique on Social Anxiety and Quality of Life of Adolescents With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is the most common serious neurodevelopmental disorder of childhood characterized by recurrent seizures, affecting approximately 0.9% of children and adolescents worldwide. Although epileptic seizures are an important element of epilepsy in children, there are many neurological, mental health and cognitive comorbidities in childhood epilepsy that increase the burden of the disease and cause a decrease in quality of life. Motivational interviewing has been found to have a positive effect on the treatment and prevention of chronic diseases; It is a patient-centered counseling that explores, strengthens, and directs the individual’s motivation for change. |
ELİZ GECTAN; | 2023-11-18 |
| 136 | ADIE-FS – Aligning Dimensions of Interoceptive Experience in Patients With Functional Seizures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Functional seizures are common and harmful. They look like epileptic seizures but are not caused by the excess electrical discharges in the brain that arise in epilepsy. Our understanding of the mechanisms that give rise to functional seizures is limited, and for this reason the development of novel treatments for functional seizures is also limited. Recent research by our and other groups has shown that interoception may play an important role in the development of functional seizures. Interoception refers to the process by which the nervous system senses, … |
MAHINDA YOGARAJAH; | 2023-11-10 |
| 137 | Effects of Information-Motivation-Behavioral Skills Model on Disease Management of Adolescents With Epilepsy: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The adolescent’s search for self-discovery and identity in physical, psychosocial, cognitive and emotional areas may become more complex with epilepsy disease management. The adolescent’s burden of treatment compliance may lead to poor adherence to the disease and worsen short- and long-term health outcomes. Disease self-management in epilepsy represents the processes required for disease knowledge, seizure control, medication adherence, increasing social support and quality of life, … |
OZLEM GUZEL POLAT; | 2023-11-01 |
| 138 | The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices individuals make influence what, and how, people remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The researcher developed a dual-task paradigm, probing how decisions in one task affect immediate recognition memory. To examine the neural mechanisms underlying model-free RL’s influence on memory, … |
SALMAN EHTESHAM QASIM; | 2023-10-31 |
| 139 | Efficacy of Non Invasive Vagus Nerve Stimulation on Motor Function of Upper Extremity in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional study is to investigate the therapeutic efficacy of non-invasive vagus nerve stimulation on upper limb function in chronic stroke patients . The main question is: •Is there a significant effect of non-invasive vagal nerve stimulation on upper limb motor function in stroke patients? Participants will be assigned into two groups. They will receive 12 sessions of true or sham transcutaneous auricular vagus nerve stimulation for 30 minutes immediately followed by 30 minutes of selected physical therapy program, three sessions per week for four weeks. |
MARWA MOSTAFA ABDEL MONEIM AFIFI; | 2023-10-01 |
| 140 | A Scoping Study to Evaluate The Potential of An Electronic Medical Device to Treat Anxiety in People Who Experience Breathlessness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this mixed methods study is to learn about cranial electrotherapy stimulation (CES) using Alpha-Stim AID in anxiety related to breathlessness in advanced lung diseases. The main question[s] it aims to answer are: – Is CES using Alpha-Stim AID acceptable and tolerable as a potential treatment in the management of anxiety in patients who experience breathlessness due to advanced chronic respiratory disease? – … |
CHRISTINA FAULL; | 2023-10-01 |
| 141 | A Prospective, Trial About Safety and Efficacy of Combined Treatment With Cerebrolysin in Acute Ischemic Hemispheric Stroke Patients Undergoing EndoVascular Treatment (EVT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is investigate the efficacy of a neuro/vascular-protective treatment with the drug Cerebrolysin in patients with acute ischemic stroke. starting immediately after completion of a EVT therapy. The main question the study aims to answer is: If a 10 days treatment with the neuro/vascularprotective drug Cerebrolysin (30 ml/day as intravenous infusion) is able to increase the overall outcome of EVT therapy? Participants will receive intravenous treatment with Cerebrolysin (30 ml/day) starting immediately after thrombolytic therapy and being continued for 10 consecutive days as one single daily infusion. The modified Rankin Scale (mRS) 90 days after onset of symptoms will be investigated, but also the improvement in other ratings as well as the time course of the improvement. In addition to the clinical outcome measures the study will assess neuroimaging perfusion CT-Perfusion parameters to evaluate possible direct improvement in microcirculation that might be an additional mechanism of action of cerebrolysin. CT-Perfusion being done immediately after EVT will provide ability to stratify the data according to non-favorable CT-Perfusion parameters after EVT versus favoravle. |
RONI EICHEL; | 2023-10-01 |
| 142 | Developing Interoperable Tools for Anxiety and Depression Screening in Epilepsy PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized trial to compare patient-completion success of REDCap and Electronic Health Record (EHR)-based anxiety \& depression instrument delivery methods. Study hypothesis is that the screening completion proportion will vary across the 4 modalities tested. |
HEIDI M. MUNGER CLARY; | 2023-09-20 |
| 143 | Impact of Cognitive Behavioral Intervention on Adherence and Quality of Life of Epileptic Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this interventional study is to assess the impact of pharmacist-led cognitive behavioral intervention in epileptic patients. The main questions are: 1. If pharmacist-led cognitive behavioral therapy can help in improving patient medication adherence? 2. How will the cognitive behavioral therapy impact the quality of life of the patients? Participants of this study will be provided basic or advanced level counselling and educational material as part of their routine pharmacy visit. Researchers will compare the two groups (Basic and advanced) to see which of the two groups are better in term of medication adherence and quality of life. |
MATTI ULLAH; | 2023-09-10 |
| 144 | Effect of A Two-month Carbohydrate-restricted Diet on Energy Metabolism in A Seniors’ Residence: The SAGE Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study will assess the effects on glucose, ketones and other blood biomarkers fuels, cognition, quality of life, physical activity and well-being of a reduced carbohydrate menu (R-CHO) for 2 months in a population living in a residence for the elderly. This intervention study, identified as the SAGE project (phase 2), follows on from the Ketohome project (phase 1) assessing the feasibility of such a project. |
UNIVERSITÉ DE SHERBROOKE | 2023-09-10 |
| 145 | The Effect of Motivational Interviewing Based on The Calgary Family Intervention Model on Care Burden, Self-Efficacy and Coping With Stress in Parents of Children With Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral palsy (CP) is a non-progressive problem that occurs as a result of damage or lesion in the brain tissue in the prenatal, perinatal or postnatal periods for any reason, causing permanent impairment in the development of posture and movement. In addition to the impairments in the motor area in CP; It can be seen in problems such as perception, cognitive, sensory, communication, social, behavioral, musculoskeletal, epilepsy .Parents who are primary caregivers of the child with CP; They have a very important caregiver role in meeting the processes such as the treatment of the child, … |
GÜLÇIN AŞUT; | 2023-09-10 |
| 146 | Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are: * the proportion of MTB infection among school contacts of ATB patients * risk factors related to tuberculosis (TB) infection * health economic evaluation of screening strategy |
WEN-HONG ZHANG; | 2023-09-01 |
| 147 | Sodium Valproate Improves Clinical Outcomes in Patients With Acute Ischemic Stroke: A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective pilot study is intended to clarify whether the use of sodium valproate in patients with acute ischemic stroke can improve clinical outcomes, and to explore the mechanism: whether valproate could increase peripheral anti-inflammatory CD177+ neutrophils levels. Patients with acute ischemic stroke included in the study will be randomly assigned to low-dose sodium valproate group, high-dose sodium valproate group and placebo group. Besides receiving conventional treatment for stroke, 10mg/kg sodium valproate, 20mg/kg sodium valproate or normal saline were given intravenously for 3 consecutive days, … |
PEIYING LI; | 2023-09-01 |
| 148 | Vaping-Related Seizures – A Prospective Case-Crossover Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This case-crossover study evaluates the association between vaping and seizures in patients of a large academic medical center who admits to vaping and hav a planned ambulatory EEG ordered. |
PETER S TATUM; | 2023-09-01 |
| 149 | Taurine Supplementation Improves Core Symptoms in Children With Autism Spectrum Disorders: An Exploratory Randomized, Double-blinded, Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the treatment of autism spectrum disorders (ASD), medication is only an adjunct, and the main treatment modalities are education and behavioral therapy. People with autism incur huge medical and educational costs, which puts a great financial burden on families.Taurine is one of the abundant amino acids in tissues and organs, and plays a variety of physiological and pharmacological functions in nervous, cardiovascular, renal, endocrine and immune systems. A large number of studies have shown that taurine can improve cognitive function impairment under various physiological or pathological conditions through a variety of mechanisms, … |
HAO ZHOU; | 2023-08-18 |
| 150 | Examining The Effect of Foot Reflexology Massage on Seizure Frequency, Fatigue, Stress and Sleep Quality in Epilepsy Patients: Randomized Control Experimental Research PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is among the diseases that cause loss of neurological abilities regardless of any trauma. Reflexology is one of the complementary therapies based on activating the body’s self-healing power through special hand techniques applied to the feet. It is known that there are positive changes in seizure frequency, fatigue, stress and sleep quality in epilepsy patients after reflexology. This study will be conducted to determine the effect of reflexology on seizure frequency, fatigue, stress and sleep quality in epilepsy patients. |
NİHAN TÜRKOĞLU; | 2023-08-15 |
| 151 | Methylphenidate for The Treatment of Epilepsy-related Cognitive Deficits: A Randomized, Double-blind, Placebo-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Methylphenidate (MPH) is a stimulant, FDA-approved for the treatment of attention deficit hyperactivity disorder (ADHD). It is unknown, however, if stimulants would be of benefit for memory and thinking problems due to epilepsy. In this study, participants will be assigned randomly (i.e., by flip of a coin), … |
BETH A LEEMAN-MARKOWSKI; | 2023-08-14 |
| 152 | Effects of Transcutaneous Electrical Nerve Stimulation on Chemotherapy-induced Peripheral Neuropathy Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and debilitating survivorship conditions for patients with cancer, and one of the most common side effects of chemotherapy treatment. Unfortunately, … |
NOUR ALAZAM; | 2023-08-08 |
| 153 | An Open-label, Non-randomized, Single-arm Pilot Study to Evaluate The Safety and Efficacy of Multiple Pulsed Focused Ultrasound Treatment in Patients With Drug Resistant Temporal Lobe Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Participants with drug-resistant epilepsy (DRE) enrolled in this study will receive focused ultrasound (FUS) treatment with the NaviFUS System, guided by the neuronavigation system to evaluate the safety and efficacy of using NaviFUS System. During the treatment, the FUS will electronically scan and target to the assigned zones on one or both of the hippocampi. The study consists of a 60-day screening period for baseline observation prior to treatment, a FUS treatment period of 2 weeks for Cohort 1 or 3 weeks for Cohort 2 with 2 FUS treatments per week using the NaviFUS System, … |
TERRENCE O’BRIEN; | 2023-08-01 |
| 154 | Whole Body Metabolism in Children with Cerebral Palsy with Low Skeletal Muscle Mass PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: At the center of pediatrics in Copenhagen the investigators experience that the children with CP with low skeletal muscle mass have more complications and admission after for example surgery is prolonged due to these complications. In order to prevent malnutrition and energy insufficiency as well as obesity and cardiometabolic disorders in adulthood, and with the aim of defining biomarkers for energy needs, … |
METTE CATHRINE OERNGREEN; | 2023-08-01 |
| 155 | Modified Atkins Diet Versus Topiramate In Children With Epileptic Spasms Refractory To Hormonal Treatment: A Randomized Open-Label Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study has been planned to compare the efficacy and tolerability of topiramate, a commonly used second line agent, with modified Atkins diet in children with epileptic spasms refractory to hormonal treatment, in a randomized open label study. |
SUVASINI SHARMA; | 2023-07-20 |
| 156 | Role of MicroRNAs As Diagnostic and Prognostic Biomarkers of Neonatal Perinatal Asphyxia and Hypoxic Ischemic Encephalopathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypoxic-ischemic encephalopathy is the most common cause of neurological damage in the neonatal period. It has an incidence of about 1.5-2.5% of livebirths in developed countries. It is associated with a high rate of mortality and morbidity. Major neurological outcomes such as cerebral palsy, mental retardation, learning disabilities, epilepsy occur in approximately 25% of survivors. The diagnostic and prognostic tools currently available for enrollment have limitations and additional reliable biomarkers are needed for all phases of clinical management. Sarnat staging has taken on a role in identifying those infants who may benefit from treatment of hypothermia, … |
GIUSEPPE DE BERNARDO; | 2023-07-18 |
| 157 | Investigation of Motor Imaging Skills in Children With Spastic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to investigate implicit and explicit motor imagery skills in children with spastic cerebral palsy and typically developing children. The main questions it aims to answer are: – There is a difference between the implicit motor imagery skills of children with bilateral and unilateral CP. – There is a difference between the explicit motor imagery skills of children with bilateral and unilateral CP. – There is a difference between the implicit motor imagery skills of children with cerebral palsy and typically developing children. – … |
SEDA AYAZ TAŞ; | 2023-07-18 |
| 158 | Multidisciplinary Lifestyle Interventions for Neurological Disorders During The Silent Phase (MINDS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to test the impact of multidisciplinary lifestyle interventions (MLI) in neurologically healthy but at-risk individuals. It aims to find out: – if giving four different kinds of lifestyle intervention and education slows down or reverses the expression of neurological disorder or their biomarkers. – new biomarkers that either help in the early detection of neurological disease or identify the impact of various lifestyle interventions combined. Participants will be randomized to the intervention or observation arm. Various biological samples and tests, along with survey questionnaires, will be performed at the time of entering the study, … |
VINEET PUNIA; | 2023-07-13 |
| 159 | Intracranial Investigation of Neural Circuity Underlying Human Mood PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Depression is one of the most common disorders of mental health, affecting 7-8% of the population and causing tremendous disability to afflicted individuals and economic burden to society. In order to optimize existing treatments and develop improved ones, the investigators need a deeper understanding of the mechanistic basis of this complex disorder. Previous work in this area has made important progress but has two main limitations. (1) Most studies have used non-invasive and therefore imprecise measures of brain activity. (2) Black box modeling used to link neural activity to behavior remain difficult to interpret, … |
SAMEER SHETH; | 2023-07-03 |
| 160 | Treatment of Epilepsy Syndromes of Childhood With Sleep Activation Using Sulthiame: An Exploratory Study of The Short Term Effect on EEG PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively. |
UNIVERSITY HOSPITAL ANGERS | 2023-07-01 |
| 161 | Assessment of Effect of Vagal Nerve Stimulator (VNS) on Electrocorticograms Recorded By Responsive Neurostimulator (RNS) in Patients With Drug Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate whether a Vagal Nerve Stimulator (VNS) causes measurable desynchronization and reduces epileptiform activity, such as spikes and seizures, in electrocorticograms (ECOGs) recorded by a Responsive Neurostimulator (RNS) in patients who have both devices implanted. Specific aims of the study: 1. Evaluate the change in frequency of epileptiform discharges during active VNS stimulation compared to interstimulation baseline periods 2. Evaluate the change in frequency of seizures during active VNS stimulation compared to interstimulation baseline periods 3. Evaluate the change in the number of RNS activations during active VNS stimulation compared to interstimulation baseline periods 4. Evaluate the change in synchronization of background ECoG (electrocorticogram) during VNS stimulation compared to interstimulation baseline periods. |
SAMUEL DESTEFANO; | 2023-07-01 |
| 162 | Yoga for Treatment of Overactive Bladder in Pediatric Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot study is to assess the impact of yoga as a treatment modality in pediatric patients age 8-18 diagnosed with idiopathic overactive bladder as measured by validated questionnaires and urinary biomarkers. The main question it aims to answer is: Does yoga help improve overactive bladder symptoms in this patient population? Participants will take part in a weekly yoga session for a total of 6 weeks with validated questionnaires and urinary samples for biomarkers to be completed at the beginning, … |
DUKE UNIVERSITY | 2023-07-01 |
| 163 | Intravenous VAL-1221 Lafora Expanded Access Protocol (LEAP) Related Papers Related Patents Related Grants Related Experts View Highlight: Only qualified physicians treating a Lafora Disease patient may request VAL-1221 Expanded Access treatment under the Parasail Lafora Expanded Access Protocol (LEAP). According to FDA guidance, this protocol can enroll up to 10 patients. However, individual patient inclusion will ultimately be dependent on protocol eligibility, site geography, treatment requirements, and available supply of the investigational therapy. Inquiring physicians can submit a request by contacting the Central Contact personnel listed below in Contacts/Locations. |
PARASAIL | 2023-06-25 |
| 164 | Children’s Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot Related Papers Related Patents Related Grants Related Experts View Highlight: The CADET Pilot will investigate the safety and feasibility of deep brain stimulation (DBS) to treat children with Lennox-Gastaut syndrome using a novel DBS device (Picostim DyNeuMo-1). Following a 30-day preoperative/baseline assessment phase, all children will have a neurosurgical procedure to implant the device. Implantation will be followed by a 30-day phase of no stimulation (the device is off / inactive) and then a six-month phase of active stimulation (the device is on / active). |
UNIVERSITY COLLEGE LONDON | 2023-06-02 |
| 165 | Intermittent Levetricetam in Treatment of Febrile Convulsions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The American Academy of Pediatrics (AAP) in 2011 published a clinical practice guideline defining a febrile seizure as a seizure accompanied by fever (temperature ≥ 100.4°F or 38°C by any method), without central nervous system infection, that occurs in infants and children 6 through 60 months of age. Febrile seizures are further classified as simple (generalized in onset, last less than 15 minutes, and do not occur more than once in 24 hours.) or complex (FS duration longer than 15 min, repeated convulsions within the same day, and focal seizure activity or focal findings during the postictal period.). |
KARIMAN HUSSEIN TAWFIK; | 2023-06-01 |
| 166 | DataNetCP: Establishing A Hospital-based Cerebral Palsy Registry in Italy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND AND RATIONALE Cerebral Palsy (CP) is the leading cause of childhood disability, with an estimated prevalence of 2 to 2.5 per 1,000 births. This complex clinical condition encompasses motor development disorders as well as sensory, communication, cognitive, and emotional impairments. Despite the significant healthcare impact of CP, standardized guidelines for its study and treatment are lacking both nationally and internationally. Existing literature is limited by small sample sizes, inconsistent assessment tools, and insufficient etiopathogenetic and functional characterizations of different CP types. A national registry, which could offer comprehensive epidemiological data, … |
GIUSEPPINA SGANDURRA; | 2023-06-01 |
| 167 | The Effect of Sleep Hygiene Training on Seizure Frequency and Sleep Quality in Epilepsy Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a disease that can be seen in everyone, including neurological, chronic, elderly and children. An estimated 50 million people in the world have epilepsy, patients have a history of two or more seizures, the exact cause is unknown, it negatively affects home, work and school life, and it directs individuals from their independent roles to semi-dependent and fully dependent roles (Smith & Wagner & Jonathan, 2015). Neuronal networks hypersynchronization develops epileptic seizures, can cause insomnia, and sleep quality may decrease with drug treatment (Sünter and Ağan, … |
MARMARA UNIVERSITY | 2023-06-01 |
| 168 | Study on The Safety and Effectiveness of A Rehabilitation Exercise Program for Community-based Spinal Cord Injury Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In the case of spinal cord injury, patients have shown a passive attitude towards participating in leisure sports or exercise programs, and there is a lack of suitable guidelines or experience in the local community for coaching exercise and sports for spinal cord injury patients, which makes coaches feel burdened when coaching these patients. Therefore, in this study, a suitable comprehensive exercise program will be designed and prescribed for patients who reside in the local community and want to participate in leisure sports, and the effectiveness and safety of the program will be verified. Based on the results, … |
SUNGCHUL HUH; | 2023-06-01 |
| 169 | Low-Carbohydrate Dietary and Lifestyle Interventions for The Management of Long COVID-19 Syndrome: A Prospective and Interventional Randomized Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Hyper-inflammatory responses seen in acute COVID-19 are also a feature of long covid, a condition of long-term consequences that are persisting or appearing after initial infection and recovery from acute COVID-19. Long-standing, often disabling symptoms are common in long covid and can be highly varied. Common symptoms include fatigue, brain fog, muscle and chest pain, migraines, shortness of breath, anosmia, muscle weakness, and cognitive dysfunction. 35% of post-COVID patients were found to have decreased kidney function at 6 months post-discharge. In this study, … |
NURIA M. PASTOR-SOLER; | 2023-06-01 |
| 170 | Open-label Pilot Study to Assess The Efficacy and Safety of Cannabidiol Oral Solution As An Adjunctive Treatment for Children and Young Adults With Rare Disease-associated Severe Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot, open-label, phase II study. The main objective of the study is to demonstrate that Cannabidiol (CBD), used in addition to current anti-seizure medications (ASMs) reduces the number and/or severity of motor (generalized, focal, or both) seizures in children and young adults with rare disease-associated severe epilepsy. Secondary objectives include assessment of safety and tolerability, changes in behaviour, cognition and sleep, pharmacokinetic interaction with concurrent ASMs. |
RENZO GUERRINI; | 2023-06-01 |
| 171 | Onchocerciasis-Associated Epilepsy, An Explorative Case-control Study With Viral Metagenomic Analysis of Onchocerca Volvulus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an exploratory case control study with the aim to compare the Onchocerca volvulus virome between persons with onchocerciasis-associated epilepsy (OAE) and persons with onchocerciasis but without epilepsy. The main question we want to address is: Is there a virus contained in the O. volulus worm that may have a pathogenic role in causing OAE. In Maridi County, South Sudan, 20 persons with OAE with onchocerciasis nodules, and 20 age- … |
ROBERT COLEBUNDERS; | 2023-06-01 |
| 172 | Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is one of the most common serious chronic brain disorders of childhood. The causes of epilepsy include :acquired brain damage, altered metabolic states, inborn brain malformations, and genetic causes. At present, antiepileptic drugs (AEDs) are the first line therapy for resistant epilepsy (RE) , and the second line is surgery , … |
MONA MOHAMMED ABDELLATIEF; | 2023-06-01 |
| 173 | The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations; Does Topiramat or Zonisamide Cause Metabolic Acidosis? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations |
ONUR KUCUK; | 2023-05-22 |
| 174 | Foot Progression Angle in Relation to Spatiotemporal Parameters of Gait in Children with Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study was applied to assess the difference of the foot progression angle and measuring spatiotemporal parameters of gait among the three age groups (five to six, six to seven and seven to eight years), of diplegic cerebral palsied children and to investigate the relation between FPA of right and left lower extremity and spatiotemporal parameters of gait in diplegic cerebral palsied children. Sixty diplegic cerebral palsied children from both sexes with age ranged from five to eight years old were participated in this study. Children were selected from the outpatient clinic of faculty of physical therapy, … |
HISHAM ELSAWY; | 2023-05-15 |
| 175 | A Randomized, Double-blind, Placebo-controlled, Crossover Study of The Effects of Single Doses of AUT00201 in Patients With Myoclonus Epilepsy and Ataxia Due to Potassium (K+) Channel Mutation (MEAK) Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, double-blind, placebo-controlled, crossover study to assess the safety, tolerability, and pharmacokinetics of single doses of AUT00201 at 100 mg or matching placebo in patients with myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK). |
MICHAEL GELFAND; | 2023-05-12 |
| 176 | Virtual Reality’s Impact on Children With Type 1 Diabetes: A Randomized Cross-over Trial on Anxiety, Pain, Adherence, and Glycemic Control PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: For children with type 1 diabetes (T1D), pain and needle phobia can cause postponing of changes in insulin pump infusion sets and continuous glucose monitors, and thus worsen glycemic control. We aim to assess the effectiveness of virtual reality (VR) technology, in reducing pain and anxiety, and improving regimen adherence and glycemic control among children with type 1 diabetes (T1D). Children with T1D, managed with continuous glucose monitoring and insulin pumps, … |
SHEBA MEDICAL CENTER | 2023-05-10 |
| 177 | Collaborative Care to Improve Quality of Life for Anxiety and Depression in Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized effectiveness/implementation trial comparing a 24-week neurology-based collaborative care intervention to usual neurology care among 60 adults with epilepsy. |
HEIDI M MUNGER CLARY; | 2023-05-04 |
| 178 | Interest of A Specific Care Pathway for The Management of Catamenial Epilepsy Catamenial Epilepsy: Status Report and Point of View of A Cohort of Patients Who for Drug-resistant Epilepsy at The TOULOUSE University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study of patients with catamenial epilepsy. Catamenial epilepsies are defined as epileptic seizures during the menstrual cycle. Today, there are no recommendations and no care pathway for these patients. The aim of this study is to assess the number of patients reporting a link between the occurrence of their epileptic seizures and their menstrual cycle. |
ANNA GOSSET; | 2023-05-03 |
| 179 | Discard The Curative Causes of Late Onset Epilepsy: The Role of Brain 18F-FDG PET PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Etiology and cognitive prognosis in late onset epilepsy differ from young adults epilepsy. At the epilepsy onset, this is crucial to detect potential curative/treatable brain disorders. After classical investigation including morphological brain imaging, EEG, clinical assessment, which added value may have brain FDG PET in the diagnosis and prognosis evaluation? |
TYVAERT LOUISE; | 2023-05-02 |
| 180 | Validation of The Mjn-SERAS Solution for The Detection and Prediction of Epileptic Seizures in Epilepsy Drug-resistant Patients, During Their Day-to-day Activity, to Find Out The Impact in A Normalised Environment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, multicentre, postmarketing, pilot clinical study is proposed to validate in the day-to-day life a medical device (mjn-SERAS), which has already been validated and certified in Europe. The patient’s characteristics about epilepsy, drug-resistant epilepsy, inclusion and exclusion criteria for the study. This new validation will take place in the participant’s normalised environment, in individuals between 12 and 65 years of age, … |
ANTONIO GIL-NAGEL; | 2023-05-01 |
| 181 | An Open Label Benzodiazepine Study for The Treatment of Seizure Clusters in A Third Level Mexican Neurological Center PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine the efficacy in seizure reduction when comparing orodispersable clonazepam versus usual treatment (i.e. medication load, intravenous high- dose benzodiazepines) of seizure clusters in a third level center of care in Mexico city. |
ELMA PAREDES-ARAGÓN; | 2023-05-01 |
| 182 | Collaborative Care for Anxiety and Depression in Posttraumatic Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to evaluate a 6 month change in quality of life in subjects who receive collaborative care calls compared to those subjects who receive usual neurology care. This is a 2-site trial comparing a 24 week neurology-based collaborative care program to usual neurology care among a total of 60 adults with post-traumatic epilepsy. |
HEIDI M. MUNGER CLARY; | 2023-04-30 |
| 183 | A Multicenter, Open-label, Long-term, Safety, Tolerability, and Efficacy Study of XEN1101 in Subjects Diagnosed With Epilepsy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the long term safety, tolerability, pharmacokinetics (PK), and efficacy of XEN1101 in subjects with Focal Onset Seizures (FOS) or Primary Generalized Tonic-Clonic Seizures (PGTCS) for the treatment of seizures for up to 3 years. |
XENON PHARMACEUTICALS | 2023-04-25 |
| 184 | An Observational Study of Epilepsy: Biology and Outcomes Using Real-world Data PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn more about phenotypic, genetic, biochemical, neurophysiological and radiological patterns in epilepsy. Participants will be asked to consent to use of clinical and paraclinical data (obtained during standard care) for research, and will be asked to donate blood samples at their routine clinic visits. |
KHALID HAMANDI; | 2023-04-24 |
| 185 | Effects of Recorded Music on Clinical and Electroencephalography (EEG) Seizure Activity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research is being done to determine if Mozart music and/or age-appropriate music can reduce the frequency of seizures and epileptiform discharges. |
SARAH KELLEY; | 2023-04-22 |
| 186 | The Acute Effect of Manual Massage Therapy on Daytime Napping in Poor Sleepers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the quest for optimal physical and mental performance and recovery, people are constantly exploring various strategies to enhance their overall well-being. Daytime napping helps mitigate the effects of inadequate nighttime sleep, allowing people to reduce fatigue and potentially improve physical performance. Research has also shown that strategically timed naps can significantly boost athletic performance, improve cognitive function, and reduce daytime fatigue. Short naps lasting between 10 to 60 minutes are ideal for quickly boosting alertness and cognitive function. Additionally, they can facilitate a complete sleep cycle, including REM sleep, … |
GIORGOS K. SAKKAS; | 2023-04-03 |
| 187 | Cathodal Transcranial Direct Current Stimulation in Patients With Drug-resistant Focal Epilepsy: Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The basis of this project is the application of cathodal tDCS in patients with drug-resistant focal epilepsy including patients whose seizures persist after epilepsy surgery, who rejected epilepsy surgery, and/or who are not suitable for surgery. For this purpose, 5-day consecutive cathodal electrical stimulation sessions will be used with personalized electrode montage according to the patient’s seizure focus. In this context, the changes in seizures frequency and epileptic discharges will be examined for the first week and 12th week after the tDCS sessions through the seizure diary of the patients and the electroencephalogram (EEG) recordings to be taken. In addition, … |
EZGI TUNA ERDOĞAN; | 2023-04-03 |
| 188 | Electro-clinical Features and Functional Connectivity Analysis in SYN1 Gene Mutation-related Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: SYN1 gene mutation is an X-linked gene mutation that causes numerous pathological manifestations such as seizures and neurodevelopmental disorders. A few descriptions of this disease have been published in the last decade, but the electro-clinical features of epilepsy are still largely unknown. No analysis of electroencephalographic connectivity has yet been performed. The aim of this study is to perform a detailed electro-clinical seizure analysis and electroencephalographic analysis in patients with a SYN1 gene mutation, in an attempt to identify a characteristic pattern that would allow earlier diagnosis and better understanding and management of this disease. |
LAURE MAZZOLA; | 2023-04-01 |
| 189 | The Mechanism of Theta Burst Stimulation (cTBS) in The Treatment of Drug-refractory Epilepsy Targeting The Dentate Nucleus of Cerebellum: An Exploratory Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In our previous cross-over study–the continuous θ burst stimulation (cTBS) targeting cerebellum dentate nucleus of 44 drug-refractory epilepsy (DRE) patients, a significant reduction in seizure frequency was observed. However, the mechanism of this target to reduce seizures is still unknown. This study aims to explore the mechanism of cTBS targeting cerebellum dentate nucleus for DRE, in order to provide theoretical support for this treatment method. A total of 25 patients with DRE and 10 healthy volunteers will have 2-week cTBS treatment via accurate navigation to bilateral cerebellar dentate nucleus. Participants will be took TMS-EEG, functional magnetic resonance imaging, … |
XIJING HOSPITAL | 2023-04-01 |
| 190 | Comparison Study of Electrocardiogram Indexes in Patients With Epilepsy, Patients With First Seizure and Normal Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: According to recent advances in epileptic heart and sudden unexplained death in epilepsy, in this study the investigators aimed to compare ECG findings in patients with epilepsy, patients who had experienced their first seizure and patients without history of seizure. |
NASIM TABRIZI; | 2023-03-21 |
| 191 | Utility of A Computational Biomarker (BioEP) in Supporting Clinicians’ Decision Making in Patients Presenting to An Adult Epilepsy Service First-seizure Clinic: A Prospective Diagnostic Belief Updating Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this belief updating study is to assess the utility of BioEP as a complementary support tool in aiding clinical decision making in adults in first seizure clinics. The main outcomes we shall measure are: – Clinicians’ perception of seizure probability. – Clinicians’ decision to recommend commencing or deferring ASM (anti-seizure medications) – Clinicians’ decision to refer for additional investigations/services. Participants will consent to have their EEG (that is taken at their routine care) to be used in the study. There is not extra burden to the participants taking part in the study. |
NEURONOSTICS | 2023-03-01 |
| 192 | The Efficacy and Safety of Minocycline in The Treatment of Drug-resistant Epilepsy in NORSE Patients: An Open-label, One-arm Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Exploring the efficacy and safety of oral minocycline combined with antiepileptic drugs in the treatment of drug-resistant epilepsy in NORSE patients, obtaining preliminary research data, and providing evidence and data support for the next large-scale randomized controlled clinical study. |
LI HUI; | 2023-03-01 |
| 193 | Stimulation-Induced Changes in Fronto-Limbic Connectivity Control Regulation of The Emotional Response to Threat PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, … |
ADAM GOODMAN; | 2023-03-01 |
| 194 | How Would The Creation of A Follow-up Methodology in Consultation Improve The Care of The Epileptic Patient? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observationnal study is to identify the informative and educational needs of epilepsy patients to avoid interrupting the therapeutic pathway. The main question it aims to answer are : – Identify the patient’s expectations of a nurse specializing in epilepsy in the areas of information, predictive elements of good care and adaptation to their state of health – Identify under-addressed or misunderstood themes – Identify patient resources and interventions already in place – Ensuring better continuity of care – … |
HOPITAL NORD FRANCHE COMTE | 2023-02-20 |
| 195 | DigitalEPI – A Prospective Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Not all patients with epilepsy requiring advanced checkups in specialized tertiary centers can be admitted for long-term video EEG monitoring. Home EEG recordings or home EEG monitoring using self-applicable EEG recording systems would therefore help overcome an unmet need in the treatment of such patients. Dry electrode EEG systems are more user-friendly than wet electrode EEG systems. In this study, the quality of EEG recordings with a novel dry electrode EEG system (Atlas with dry electrodes) will be compared with the quality of recordings with a conventional wet electrode EEG system used in clinical practice. Secondly, … |
CHRISTOPH BAUMGARTNER; | 2023-02-15 |
| 196 | A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate The Safety, Tolerability, and Efficacy of XEN1101 As Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of XEN1101 administered as adjunctive treatment in primary generalized tonic-clonic seizures (PGTCS). |
XENON PHARMACEUTICALS | 2023-02-14 |
| 197 | A Feasibility Study of A Step-goal Based Physical Activity Intervention in People With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to evaluate the feasibility of a 12-week, telehealth delivered, step-goal based physical activity intervention in people with epilepsy. The study team will also evaluate the physical activity profiles of people with epilepsy both at rest and when engaged in physical activity and gather information on the effect of the intervention on epilepsy and epilepsy associated comorbidities. |
HALLEY ALEXANDER; | 2023-02-13 |
| 198 | Study of The Determinants of Dream Recall and Content in Patients With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dreaming is a sleep-associated cognitive process whose neural substrates and functions remain poorly understood. In healthy subjects, the frequency of dream recall is influenced by several factors such as age, gender, interest in dreams and sleep quality. The content of dreams mainly depends on waking life experiences, especially when they are recent and have a strong emotional content. The function of dreams remains debated but it is widely accepted that dreams play a role in emotional regulation. Modifications in dreams are observed in several neurological diseases and sleep disorders, due to the modifications of sleep related to these diseases, … |
HOSPICES CIVILS DE LYON | 2023-02-07 |
| 199 | Use of Virtual Reality in Providing Pain Management, Comfort and Satisfaction After Thyroid-Parathyroid Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effect of virtual reality application on pain management, comfort, and care satisfaction in patients undergoing thyroidectomy-parathyroidectomy. The main questions it aims to answer are: 1. Does the use of virtual reality reduce the level of postoperative pain in patients undergoing thyroid and parathyroid surgery? 2. Does the use of virtual reality increase the postoperative comfort level in patients undergoing thyroid and parathyroid surgery? 3. Does the use of virtual reality increase the level of satisfaction after surgery in patients undergoing thyroid and parathyroid surgery? Participants in the experimental group watched a virtual reality video containing nature and sea images and music playing in the background for 15 minutes. Participants in the control group received routine clinical care after thyroidectomy and parathyroidectomy. The pain levels of the patients in the experimental group were lower, and the comfort level was higher than in the control group. There was no difference between the groups in terms of satisfaction level with nursing care. |
SACIDE YILDIZELI TOPCU; | 2023-02-02 |
| 200 | CAUSAL MECHANISMS OF DISTRIBUTED BRAIN NETWORK FUNCTION DURING EPISODIC MEMORY RETRIEVAL PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Brain stimulation is a means to potentially remediate symptoms in a range of neurological and psychiatric diseases, however, precise targeting of stimulation is necessary to ensure efficacy. The proposed project will use recent advances in functional magnetic resonance imaging to delineate distributed brain networks within individuals, and use these network maps to guide selection of intracranial electrodes for stimulation during an episodic memory task. The resulting data will refine the current understanding of the neural systems involved in episodic memory, and provide a proof-of-principle for the use of individual-level network mapping to guide brain stimulation, … |
RODRIGO BRAGA; | 2023-02-01 |
| 201 | Pilot Study of Transcranial Direct Current Stimulation (tDCS) to Treat Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to see to what extent electrical stimulation applied to the scalp (transcranial direct current stimulation or tDCS) can reduce the number and intensity of epileptic seizures. |
BRIAN N. LUNDSTROM; | 2023-02-01 |
| 202 | A Randomised, Placebo-controlled Trial to Investigate The Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Household Contacts of SARS-CoV-2+ Adults and Children PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronavirus-induced disease 2019 (COVID-19) is an infection caused by a virus whose full name is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is a new and rapidly-spreading infectious disease which carries a significant risk of death, has brought massive economic impact globally and has proved hard to contain through public health measures. While we currently have effective vaccines, … |
PAUL MONAGLE; | 2023-01-30 |
| 203 | Retrospective Study on The Use of CENOBAMATE As Adjunctive Treatment in A Cohort of Patients Suffering From Epilepsy With Focal Onset Seizure (FOS) and Enrolled Into The Early Access Program (EAP) in Germany, France and UK PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Cenobamate is a newly-FDA and EMA approved drug used to treat -focal-onset seizures in adult patients. The aim of the current study is to analyse retrospectively the overall effectiveness and tolerability of cenobamate from real-world data collected in patients who partecipated in the Early Access Program (EAP) and were treated with cenobamate as adjunctive ASM. |
SYLVAIN RHEIMS; | 2023-01-27 |
| 204 | Cenobamate in Adults With Focal-Onset Seizures: A Real-World Multicenter Observational Italian PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The BLESS Study contributes to filling this information gap by collecting data from the Italian clinical practice and the Compassionate Use Program, to better characterize the clinical profile of cenobamate describing its effectiveness, safety and tolerability in adult patients diagnosed with uncontrolled focal epilepsy despite the use of at least two antiepileptic medicinal products. |
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S P A | 2023-01-24 |
| 205 | Validation Study for Monitoring of Focal Onset Epileptic Seizures With A Wearable Seizure Monitoring Device, EpiCare@Home PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to validate a wearable seizure monitoring device, EpiCare@Home, as an objective seizure monitoring tool for people with focal onset epileptic seizures. The device continuously records brain, cardiorespiratory, and physical activity data. The study aims to 1) collect benchmark data for seizure detection algorithm development and validation, and 2) evaluate the performance of the device in clinical and at home workflows. Participants will wear the device during a routine Epilepsy Monitoring Unit (EMU) admission. Additionally, they can continue wearing the device at home after the EMU admission. |
BENJAMIN VANDENDRIESSCHE; | 2023-01-23 |
| 206 | Effects of L-Carnitine Supplementation on Gastric Emptying in Children With Drug Resistant Epilepsy on Ketogenic Diet PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was conducted on thirty children aged from12 months to 18 years newly diagnosed with drug resistant epilepsy and following up at Pediatric Nutrition and Neurology Outpatient Clinics assigned randomly into 2 groups, group1: patients who started ketogenic diet with L-carnitine and group2: patients who started ketogenic diet only. |
HAYA ESSAM IBRAHIM; | 2023-01-20 |
| 207 | Effect of The Nutritional Support System (NSS) on Neuromotor Alterations in Patients With Cerebral Palsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study to determine the impact of a nutritional support system (NSS) on neuromotor alterations in patients with cerebral palsy. |
FERNANDO LEAL-MARTINEZ; | 2023-01-16 |
| 208 | Open Label Single Center Trial Evaluating The Efficacy and Safety of Diazepam in GAD65 Associated Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether diazepam reduces the frequency of seizures in GAD65 antibody associated epilepsy. |
KELSEY M. SMITH; | 2023-01-11 |
| 209 | Efficacy of Ketone Esters for Children With Drug Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the efficacy of add-on exogenous ketone esters for treating children with drug-resistant epilepsy |
ELSAYED ABDELKREEM; | 2023-01-10 |
| 210 | Efficacy of Exogenous Ketone Esters for Children With Refractory Convulsive Status Epileptics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the efficacy of add-on exogenous ketone esters for the treatment of children with refractory generalized convulsive status epilepticus |
ELSAYED ABDELKREEM; | 2023-01-10 |
| 211 | Trial of Auricular Vagus Nerve Stimulation in Painful Covid Long PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients infected with Covid 19 suffer from frequent pain (headache, migraines, joint pain, muscle pain) in the acute phase which may persist after a stay in intensive care or in an intensive care unit, in the event of post-traumatic stress syndrome, pre-existing comorbidities. The pain mechanisms observed during the covid epidemic are nociceptive / inflammatory pain, neuropathic pain, … |
STÉPHANIE MAUBOUSSIN CARLOS; | 2023-01-09 |
| 212 | Thalamic Stimulation for Epilepsy Study Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigator aims to perform cortical stereo electroencephalogram (sEEG) recordings during simultaneous anterior nucleus of the thalamus (ANT) recording and stimulation to better understand the following: 1) how the ANT is involved in various seizure types; 2) which cortical regions are modulated by established ANT stimulation patterns; and 3) how novel ANT stimulation patterns modify epileptogenic cortical activity. Together, this knowledge will advance ANT deep brain stimulation (DBS) therapy by providing a physiologic basis for patient selection for ANT DBS, … |
DEREK SOUTHWELL; | 2023-01-07 |
| 213 | Does Levetiracetam and Carbamazepine Impact The Autonomic Activity of Children With Self-limiting Focal Epilepsy? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this cross-sectional study is to learn about autonomic cardiac profile changes in children with self-limiting focal epilepsy using levetiracetam and carbamazepine in children with self-limiting focal epilepsy syndrome. The main questions is it aims to answer are: 1. Are heart rate variability and autonomic tone different among healthy controls and children with epilepsy? 2. Does Levetiracetam and carbamazepine affect autonomic tone differently among children with self-limiting focal epilepsy? |
İPEK DOKUREL; | 2023-01-01 |
| 214 | Evaluating The Feasibility of A Portable Electroencephalogram Device in Diagnosing Transient Ischemic Attack and Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: When an individual experiences a sudden onset of neurological symptoms, such as one-sided weakness, visual abnormalities, and/or slurred speech, there is concern that they are having a transient ischemic attack/stroke. A stroke is a medical emergency that requires immediate treatment and further evaluation to prevent a future stroke. Unfortunately, when a patient presents to the emergency department or a clinic with transient or mildly observable neurological symptoms, it is difficult to diagnose a stroke and many times, … |
MARK BOULOS; | 2023-01-01 |
| 215 | Quantitative EEG Neurofeedback As An Add-on Therapy For Attention-deficit Hyperactivity Disorder (ADHD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Attention deficit/hyperactivity disorder (ADHD) is a common neurological disorder in children, mainly manifesting as attention deficit, excessive hyperactivity, and impulsivity. It is a chronic condition that affects millions of children and often continues into adulthood. The prevalence of ADHD in the worldwide is approximately 5%, predominantly occurring in boys, and more than half of patients continue to experience symptoms into adulthood. Children with ADHD have moral disorders and learning difficulties, and these factors will seriously affect their academic achievements and familial and social relationships; thus, treatment is necessary. Currently, the treatment for ADHD is usually pharmacological intervention, such as methylphenidate, … |
MOHAMED EMAD ELDEEN MAHMOUD; | 2023-01-01 |
| 216 | A Study of The Knowledge and Attitude Towards Epilepsy Among Close Relatives of People With Epilepsy and Their Impact on The Patient’s Quality of Life PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a common neurological condition that affects personal and familial behavior and social support . About 50 million people worldwide suffer from epilepsy and the prevalence of active epilepsy in developing countries is 5 to 10 per 100 persons . Individuals with epilepsy may suffer from psychological issues such as depression, anxiety, and psychosis . Accordingly, living with a person with epilepsy will provide some challenges, … |
MOHAMED ADEL ABDELLAH; | 2023-01-01 |
| 217 | Investigation of The Effects of Transcranial Direct Current Stimulation Combined With Stabilization Exercises on Functional Status, Cognitive Functions, and Sleep Quality in Individuals With Chronic Neck Pain: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of study was to investigate the effect of cervical stabilization exercises (CSE) combined with tDCS on functional status, cognitive functions and sleep quality in individuals with chronic neck pain. A total of 29 individuals with chronic neck pain (33.06±14.81 age) were included in the study. Combined CSE with tDCS (2 mA/20 min) was applied to the experimental group (n=10); only CSE was applied to the control group (n=10); placebo tDCS (0 mA/20 min) and CSE were applied to the sham group (n=9). Before and after the 8-week intervention comprising a total of 16 sessions, … |
TUĞBA DERE; | 2023-01-01 |
| 218 | Bioequivalence Study of Sodium Valproate and Valproic Acid Extended Release Tablets in Healthy Human Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bioavailability is the extent and rate to which the active drug ingredient or active moiety from the drug product is absorbed and becomes available at the site of drug action. Bioavailability of an active substance delivered from a pharmaceutical product should be known and reproducible. In the past, … |
RAJANI SHAKYA; | 2023-01-01 |
| 219 | The Ketogenic Diet for Alzheimer’s Disease: A Randomized Controlled Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The ketogenic diet (KD) is a metabolic shift, which stimulates the liver oxidation of fatty acids to produce ketone bodies. These ketone bodies represent an alternative fuel source for the brain. The benefits of KD in epilepsia have been demonstrated for decades. This diet may also provide benefits in Alzheimer’s disease (AD) where neuronal glucose utilization declines from the early stage. Besides, the KD could decrease neuroinflammation, oxidative stress and enhance mitochondrial biogenesis. In murin models of AD, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-01-01 |
| 220 | Music As An Adjunctive Epileptic Seizure Treatment Option PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mozart’s Sonata for two pianos in D major (K448) has been found to reduce the presence of abnormalities in the electroencephalograms of patients with epilepsy. We will examine the long term effects of listening to the K448 sonata on seizure frequency and cognitive functioning in children with drug resistant epilepsy allocated to either a study group or a control group. Patients’ parents will complete a seizure diary for the whole study period, … |
DOMENICO SERINO; | 2023-01-01 |
| 221 | A Phase 1b Randomized, Double-Blind, Placebo Controlled, Crossover Study to Evaluate The Safety, Tolerability, and Efficacy of Two Doses of RLS103 (Inhaled Dry Powder Cannabidiol [CBD]) in A Clinical Model of Photosensitive Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate RLS103 for safety and suppression of the epileptic photoparoxysmal response compared to placebo. |
RECEPTOR LIFE SCIENCES | 2023-01-01 |
| 222 | Fenfluramine for The Treatment of Refractory Epilepsy in Adult Dravet Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Full Title: Fenfluramine for the treatment of refractory Epilepsy in Adult Dravet patients Short Title: Fenfluramine for Adult Dravet patients Clinical Phase: Phase III Sample Size: A total of 15 participants will be included in the study. Study Population: Adult patients (18 years and older) with drug-resistant epilepsy (maintained on their existing medications, with exception of cannabidiol) and genetically confirmed Dravet syndrome will be recruited to participate in the study. Accrual Period: 12 months Study Design: Open label, non-randomized and uncontrolled add-on trial in adults (18 years of age and older) residing in Ontario, … |
DANIELLE ANDRADE; | 2022-12-10 |
| 223 | Transcutaneous Electrical Auricular Vagus Stimulation and Heart Rate Variability PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcutaneous electrical stimulation of the auricular vagus nerve (TENS) is a promising method of neuromodulation of the autonomic nervous system in patients with various pathologies. The use of this method requires the determination of a reliable biomarker of successful activation of the vagus nerve using TENS. Currently, most studies focus on the assessment of heart rate variability (HRV) as a marker of the functioning of the autonomic nervous system. Despite the physiological justification of HRV as a biomarker for TENS, the data on the effects of TENS on HRV are ambiguous. In some studies, … |
VLADIMIR SHVARTZ; | 2022-12-01 |
| 224 | The Prevalence and Risk Factors of Coagulopathy in Pediatric Patients Undergoing Surgery for Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The hematologic consequences of novel Anti-seizure medications (ASMs) are rarely reported. Whether coagulation dysfunctions increase the risk of peri-operative bleeding remains controversial. The research is performed to investigated the incidence and risk factors of preoperative coagulation dysfunction in children undergoing surgery for epilepsy and their impact on surgery. |
CHILDREN’S HOSPITAL OF FUDAN UNIVERSITY | 2022-12-01 |
| 225 | Association Between PM2.5 Exposure and Nrf2-depended Ferroptosis Changes in Seizures Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This cohort study aims to discover the possible effects of PM2.5 exposures on the Nrf2- dependent ferroptosis pathway in seizure patients. This observational cohort’s main question is whether PM2.5 exposures will affect the Nrf2- dependent ferroptosis pathway in seizure patients. Participants will be divided into two groups: the control group and the air pollution to detect the biomarkers of the Nrf2- dependent ferroptosis pathway in seizure patients |
AFFILIATED HOSPITAL OF JIANGNAN UNIVERSITY | 2022-12-01 |
| 226 | Correlation Between Bruxism And Cervical Function PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Bruxism is defined as an unconscious oral habit of dysfunctional rhythmic pressing, clenching and grinding of the teeth when performing movements that are not part of the … |
OLIVIA IBRAHIM ABDELMESSEH ANGLY; | 2022-12-01 |
| 227 | Impact of COVID-19 Pandemic on Epilepsy Evaluations in The Pediatric Emergency Department PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background. Seizures are a common cause of evaluation in the pediatric emergency department (ED). Several studies about the impact of COVID-19 pandemic on ED attendances report a considerable reduction in general pediatric care. The aim of our study was to evaluate the impact of COVID-19 on the admission to the pediatric ED for seizures. Materials and methods. We performed a retrospective study to assess the rate of ED admission for seizures at the pediatric ED of the Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan between January 2017 and December 2021, … |
ALBERTO CAPPELLARI; | 2022-11-30 |
| 228 | Systematic Evaluation of Vagus Nerve Stimulation Parameters on Cardiac Rhythm, Laryngeal Muscle Electromyography, and Vagus Nerve Activation in Acute and Chronic Implantations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to measure the activation of the vagus nerve and the side effects of vagus nerve stimulation (VNS) (neck muscle contractions, changes in heart rate) across a range of stimulation parameters typically used in VNS therapy for epilepsy (pulse durations, pulse amplitudes, pulse repetition rates). This mapping of the parameter space may inform future device programming to improve electrical activation of the vagus nerve and/or to reduce side effects, … |
WARREN M GRILL; | 2022-11-28 |
| 229 | Comitial Prophylaxis in Neurosurgery in Patients Who Have Undergone Intracranial Surgery Programmed Supratentorial Surgery (Exeresis or Biopsy) Between 2019 and 2022 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: JUSTIFICATION Anti-epileptic prophylaxis has long been a systematic practice for supra-tentorial intracranial surgeries. Since 2021, European guidelines no longer recommend this prophylaxis and practices have evolved. We therefore propose to compare epileptic seizure’s occurrence in the first postoperative month between two groups of neurosurgical patients.The first group consists of patients treated between January 2019 and late 2020 who were given systematic prophylaxis. Patients from the second group were treated between 2021 and 2022 and did not receive any prophylaxis. The secondary objective will consist in identifying the number of patients placed on prophylaxis, the length of prophylaxis, … |
UNIVERSITY HOSPITAL BREST | 2022-11-22 |
| 230 | The Effect of Reiki Applicatıon on Sleep and Qualıty of Life in Epılepsy Patıents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After the general period of positive social adjustments, epilepsy is in a high life cycle to control seizures. During seizures in epilepsy, patients’ quality of life and antiepileptic life span can be seen in daily life such as daily life and daily awakenings. Reiki, which has been proven by studies in health problems such as fatigue and pain; an energy that can be unblocked or applied in a non-applicable way can benefit from a therapy that can be applied by touch or remotely, without negative effects. In the literature, … |
GÜLCAN BAHCECIOĞLU; | 2022-11-11 |
| 231 | Evaluation of Virtual Reality Glasses Use During Inhaler Treatment in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Virtual reality (VR) glasses are technological devices that are often used in medical fields recently and are seen as suitable for distracting children. In the last few years, many studies have been conducted to facilitate pediatric patients against painful or frightening medical procedures. For uncomfortable procedures, distracting the child’s attention is seen as the most important point. VR technology has been used for procedures such as burn cases, tooth extraction, intramuscular injection, intravenous cannula, lumbar puncture, … |
BERKER OKAY; | 2022-11-10 |
| 232 | The Effect of Jigsaw Technique on Childhood Epileptic Seizure Management Knowledge and Attitudes of Nursing Students PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the effect of the education given to nursing students with the Jigsaw technique and traditional method on their knowledge and attitudes about childhood epileptic seizure management. |
AYŞE KAHRAMAN; | 2022-11-02 |
| 233 | A Prospective, Randomized, Double-blind, Placebo-Controlled Phase Ⅱ Study to Evaluate The Efficacy of Adjunctive Everolimus Treatment in Patients With Refractory Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project is a prospective, randomized, placebo-controlled, double-blind study that will evaluate the clinical efficacy of everolimus as an adjunctive treatment in adult patients diagnosed with refractory epilepsy. |
NATIONAL INSTITUTE ON DRUG DEPENDENCE CHINA | 2022-11-01 |
| 234 | High-field MR Imaging in Migraine and Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this project, the aim is to recruit patients with drug resistant epilepsy and those suffering from migraine. Interestingly, patients suffering from epilepsy are also more often reporting to suffer from migraine. The pathobiology is understudied, but it is believed that both etiologies results from brain networks changes. A clinical certified 7T Terra Siemens scanner will be employed to assess in all participants (including healthy controls) how the microstructure differs in disease specific areas. Patients will further be clinically assessed as well as undergo questionnaires. |
PATRICK FREUND; | 2022-11-01 |
| 235 | Vagal Nerve Stimulation in Enhanced Stroke Recovery: The VALOR Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Vagal Nerve Stimulation is a novel proven therapy for patients with chronic ischemic stroke. The primary objective of this registry is to assess the safety of vagal nerve stimulation for stroke recovery through monitoring the occurrence of serious adverse events associated with the surgical procedure or subsequent paired rehabilitation protocol. This registry will monitor patients undergoing VNS for stroke recovery in the Mount Sinai Health System and collect clinical and procedural details, objective outcomes, and patient-reported outcomes associated with vagal nerve stimulation for stroke recovery. |
CHRISTOPHER P KELLNER; | 2022-11-01 |
| 236 | Role of Plasma MiRNA223 and High Mobility Group Box 1(HMGB1) As Predictors of Drug Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of the role of estimation of serum level of miRNAs223 and HMGB1in detection of patient with drug resistant epilepsy. Early detection of the prognosis might help in guiding patients for proper management and treatment strategy. This may open the door for new drug trials. |
SAFAA ALI SAMIR HUSSIEN MOHAMED; | 2022-11-01 |
| 237 | Ketogenic Diet for Status Epilepticus in Infants, Children and Adolescents Aged 6 Months to 18 Years Immediately After Cessation of Convulsive Status Epilepticus; A Randomized Open Labelled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ketogenic diet being started early in those with status epilepticus and frequent or abundant discharges in EEG in comparison to just standard therapy is being evaluated here for efficacy and adverse effects. |
SHEFFALI GULATI; | 2022-11-01 |
| 238 | The Efficacy and Safety of Lamotrigine Versus Carbamazepine in Focal Epilepsy: A Randomized, Open Label Clinical Trial in Dhaka Medical College Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a serious chronic brain disorder that has a tendency towards recurrent seizures. This affects millions of people throughout the world and brings a heavy socioeconomic burden. The treatment of focal epilepsy is more challenging. Selecting an appropriate antiepileptic drug (AED) remains difficult because the chosen drug must be effective, safe and tolerable. It is important to consider the safety and efficacy of an AED for monotherapy separately. The goal of AED therapy is to achieve seizure control with little or no adverse efects, … |
REAZ MAHMUD; | 2022-11-01 |
| 239 | A Randomized, Double-blind, Placebo-controlled, Multisite, Phase 3 Study to Investigate The Efficacy and Safety of Cannabidiol Oral Solution (GWP42003-P) in Children and Adolescents With Epilepsy With Myoclonic-Atonic Seizures Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of Part A of the study to assess the efficacy and tolerability of GWP42003-P compared to placebo as an adjunctive treatment for children with Epilepsy with myoclonic-atonic seizures (EMAS) -associated seizures. Part B of this study will be conducted to evaluate the long-term safety and tolerability of GWP42003-P in participants with EMAS. |
JAZZ PHARMACEUTICALS | 2022-10-31 |
| 240 | Evaluation of The Effectiveness of Dynamic Neuromuscular Stabilization Training in Children With Lower Urinary Tract Dysfunction: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Lower urinary tract dysfunction (LUTD) is present in 2-40% of healthy children. If left untreated, it can lead to health problems such as recurrent urinary tract infections, vesicoureteral reflux and chronic renal failure. Pelvic floor physiotherapy is a globally accepted treatment for adults and children. In addition to locomotor skills, functional exercises such as motor control, core stability and balance training are important to support toilet training. Dynamic Neuromuscular Stabilization (DNS), a current stabilization approach, is a neurophysiological rehabilitation strategy based on developmental kinesiology, … |
EMINE NACAR; | 2022-10-20 |
| 241 | A Single-center, Randomized, Placebo Controlled, Double-blind, Ascending Single-dose and Repeated-dose Trial to Determine The Safety and Pharmacokinetic Profile of NPT 2042 Soft-Gelatin Capsules Administered Orally to Healthy Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study NPT 2042 CL 101 is a first in human (FIH) study to evaluate the safety and pharmacokinetics (PK) of single and repeated ascending doses of NPT 2042 in healthy adult male and female subjects. |
NEUROPRO THERAPEUTICS | 2022-10-20 |
| 242 | Assessment of The Predictive Value of Outpatient Smartphone Videos in Diagnosis of Epileptic Seizures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Accuracy of seizure diagnosis based on smartphone seizure semiology anaysis 2. Assess the factors that affect the diagnostic reliability of smartphone videos |
HEND MOHAMED ABD EL MOEZ; | 2022-10-20 |
| 243 | Aerobic Exercises Versus Laser Puncture Therapy on Immune Response Following Neck Lymph Node Dissection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Group (1): Twenty cases with decreased white blood cell counts after neck lymph nodes and deficient in blood immunological functions made up this group. They underwent aerobic exercise training on a cycle ergometer. The cases received one 15-minute session, three sessions per week, for two months, with follow-up after the course of treatment. Group (2): Twenty cases with underdeveloped blood immune systems; decreased white blood cell counts after having their neck lymph nodes removed, a low-level laser puncture was performed on the Governing Vessel 14 acupuncture point. They received a 15-minute session, three sessions per week, for two months, … |
AYA GAMAL FAWZY EL-SAYED; | 2022-10-15 |
| 244 | Brain Regions and Functional Neuronal Network Characteristics of Dexmedetomidine Analgesia Under Intraoperative FMRI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Dexmedetomidine (DEX) is a highly selective 2-adrenergic receptor agonist with significant analgesia affection. This study is planned to explore the brain regions and functional neuronal network involved in promoting analgesia of Dexmedetomidine. Methods: Select 12 patients with the proposed intraoperative MR-guided radiofrequency ablation of epilepsy. The subjects were randomized into the Dexmedetomidine group (DEX group) (n=6) and the Opioid group (OPI group) (n=6). DEX group: continuous intravenously administered 1.5 µg kg-1 h-1 dexmedetomidine 15min before anesthesia induction, continuous infusion for 15min after anesthesia induction, … |
CHAORAN NIE; | 2022-10-15 |
| 245 | Analysis of Cortical Activity in Individuals With Cybersickness Under The Influence of Multi-sensory Conditions in Virtual Reality: A Randomized Crossover Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cybersickness (CS) is characterized as a type of visually induced motion sickness, similar to traditional motion sickness, with specific clinical presentations such as dizziness, eyestrain, oculomotor disorders, blurred vision and spatial disorientation. It can be triggered when experiencing virtual reality (VR), and it affects approximately 20% to 80% of individuals who use these resources. Furthermore, the underlying mechanisms of CS are not fully understood and the use of virtual environments that have become increasingly recurrent in several sectors deserves attention, as VR is becoming commonplace in methods and techniques of assessment, … |
MARCOS JUNIO DA COSTA SILVA; | 2022-10-08 |
| 246 | Oral Health Status in A Group of Egyptian Children With Cerebral Palsy: A Cross-sectional Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to assess the oral health status in a group of Egyptian children with cerebral palsy. |
SARA KHAIRY MAHMOUD; | 2022-10-06 |
| 247 | Possible Role of Inflammatory Serum Biomarkers in Differentiation Between Epileptic Seizure and Psychogenic Non-epileptic Seizure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Evaluation of the role of TRAIL and MCP-2 in differentiation between epileptic seizure and psychogenic non-epileptic seizure. 2. Possible role to predict the prognosis of patients with epileptic seizure. |
ESRAA MOSTAFA AHMED ABDEL AAL; | 2022-10-01 |
| 248 | A Clinical Study of Epilepsy Localization and Prognosis Based on Positron Emission Tomography and Resting-state Functional Magnetic Resonance Imaging PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. By following up the prognosis of surgical patients, the application value of Cortex ID quantitative analysis in the localization of epilepsy foci was studied. 2. By studying the correlation between autonomic nerve function and epilepsy neural network in epilepsy patients, and analyzing the differences between different epilepsy patients, it can provide more information for judging the prognosis of epilepsy patients. |
LI SHUANGSHUANG; | 2022-10-01 |
| 249 | Clinical Study Evaluating The Safety of Lactobacillus Probiotic in Children With Drug Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Animal and human studies have brought up evidence supporting Gut microbial disbalance, namely dysbiosis, as a causative factor of epilepsy, especially the refractory form. thus, probiotics might constitute a safe, low-cost, and effective supplementary therapy in patients with DRE. The Lactobacillus population is probiotic bacteria that have a beneficial role in epilepsy. Lactobacillus can influence brain function through the modulation of GABA, as shown in rodent models. Moreover, … |
AMIRA ROSHDY; | 2022-09-25 |
| 250 | Fine-scale Mapping of Brain Anatomy and Function With Combined Electroencephalography and 7T Magnetic Resonance Imaging: A Single-center Study on Healthy Participants and on Tremor, Psychosis and Epilepsy Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The human brain presents outstanding challenges to science and medicine. Brain function and structure span broad spatial scales (from single neurons to brain-wide networks) as well as temporal scales (from milliseconds to years). Currently, none of the tools available for studying the brain can fully capture its structure and function across these diverse scales – the neuroimaging puzzle. This poses crucial limitations to understanding how the brain works, and how it is affected by numerous diseases. The central goal of this project is to expand currently available tools for non-invasive human brain imaging, … |
CSEM CENTRE SUISSE D’ELECTRONIQUE ET DE MICROTECHNIQUE SA RECHERCHE ET DEVELOPPEMENT | 2022-09-21 |
| 251 | Effects of 3-month Probiotic Mix Supplementation (L. Helveticus R-0052, B. Longum R-0175) on Gut Microbiota and Metabolome, Endocannabinoid and Immune Systems Activation, Along With Symptoms of Fatigue in Professional Dancers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the planned research is to assess the dynamics of changes in the elements of the gut-brain axis (GBA), the cytokine profile and the endocannabinoid system markers, after dietary supplementation with probiotics Lactobacillus helveticus Rosell-52 and Bifidobacterium longum Rosell-175 by professional dancers. Although in recent years there has been growing interest in the influence of the gut microbiota on the body’s adaptation to stress stimuli and on overall health, there is a lack of information on the influence of probiotics on systems involved in maintaining neuropsychiatric balance, … |
JAKUB WIĄCEK; | 2022-09-21 |
| 252 | Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy: A Case Study Related Papers Related Patents Related Grants Related Experts View Highlight: Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this procedure presents a high risk of increasing cognitive difficulties and may even be contraindicated for this reason alone. The difficulties found are impairments in lexical access (anomia) and verbal memory and affect more than 60% of patients. Preoperative cognitive rehabilitation could influence brain plasticity mechanisms but there are currently no recommendations on this topic. In this context, … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2022-09-20 |
| 253 | Clinic to Community© Program for Adults With Epilepsy Admitted to Emergency Departments: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Analysis of emergency department (ED) visits with a billing code for ‘epilepsy’ or ‘seizure’ found up to 37% are eligible for deferral. This study is a randomized controlled trial (RCT) of the Clinic To Community© program (C2C) as an intervention for adults with epilepsy visiting emergency departments at a mid size hospital in Ontario, Canada. Participants in the intervention arm receive patient education to improve knowledge of epilepsy and access to community-based services. Participants in the control group are wait-listed and receive patient education 12 months later. The study objective is to successfully implement, … |
KATHY N SPEECHLEY; | 2022-09-12 |
| 254 | The Effect of Self Acupressure on Fatigue and Sleep Quality in Epilepsy Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the effect of Self-acupressure application on fatigue and sleep quality in epilepsy patients. |
GÜLCAN BAHCECIOĞLU; | 2022-09-05 |
| 255 | Investigation of Long-term Outcome of Levetiracetam and Valproate in Treatment of Idiopathic Generalized Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to compare the long-term efficacy and safety of levetiracetam and valproate in treatment of idiopathic generalized epilepsy. |
NASIM TABRIZI; | 2022-09-03 |
| 256 | Determining The Effectiveness of Counterpressure Maneuvers in Pediatric Patients Presenting With Syncope to The Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients. Participants presenting to the emergency department (ED) will first provide written informed consent. In stage I, they will be asked to complete a brief survey documenting the presentation of their syncopal episode, and any prodromal symptoms they experienced. Participants that consent to the second stage of the study will either receive usual care (control arm) or training in counter pressure maneuvers alongside usual care (intervention arm; leg crossing, bending, arm tensing). These patients will be followed for one years time, … |
VICTORIA CLAYDON; | 2022-09-03 |
| 257 | Pharmacokinetics Study of Oral 2-Deoxy-D-Glucose (2DG) in Subjects With A Confirmed Diagnosis of Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: This project studies how 2-deoxy-glucose (2DG) pills are absorbed and distributed in people with epilepsy. 2DG is similar to glucose, the main energy source for the brain, but it cannot be used as energy. During seizures, neurons are at a very high metabolic state with huge glucose metabolism as glycolysis is accelerated to supply the high metabolic needs of a seizure. 2DG is taken up by cells but cannot be metabolized by the first enzyme in the glycolytic pathway, thus is stops, or clogs up, glycolysis. Since brain metabolism is almost entirely dependent on glucose as an energy source, … |
NATHAN FOUNTAIN; | 2022-09-02 |
| 258 | Comorbidities of Epilepsy(Cognitive and Psychiatric Dysfunction) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is the second commonest chronic neurological disorder in developed countries ,comorbidity refers to the co-occurrence of two conditions with greater frequency than found in the general population |
HASNAA ABDALLAH; | 2022-09-01 |
| 259 | Integrating An Evidence-based Mental Health Intervention Into Primary Health Care to Improve Outcomes for Refugees With Hypertension, Diabetes, and Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the impact of an evidence-based mental health intervention (Common Elements Treatment Approach) on medication adherence, behavioral improvement and clinical outcomesamong adults taking medication for hypertension, diabetes and epilepsy using a two-arm randomized wait-list controlled trial among adult refugees in Mae La camp, Thailand. |
INTERNATIONAL RESCUE COMMITTEE | 2022-09-01 |
| 260 | RENAISSANCE Study: A Phase 2, Multicenter, Open Label Safety and Tolerability Study of SPN-817 in Adult Patients With Treatment Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the safety and tolerability of SPN-817 in adults with treatment resistant seizures |
SUPERNUS PHARMACEUTICALS | 2022-09-01 |
| 261 | Electrophysiological Evaluation of Autonomic Dysfunction in Persons With Temporal Lobe Epilepsy and Its Relation Ship With Sudden Unexpected Death of Epileptic Patient (SUDEP) Risk Development( PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aimed at detection of autonomic dysfunction among cases with temporal lobe epilepsy; using different electrophysiological techniques. Moreover, it aimed at finding any correlation between electrophysiological tests and SUDEP risk. |
REEM MAHMOUD GABR; | 2022-09-01 |
| 262 | Effects of Sensorimotor Rhythm Neurofeedback on Insomnia in Patients With Benign Brain Tumors Underwent Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Insomnia is the most common sleep disorder in patients with primary brain tumors. In the past, 21.5% to 59.2% of patients with primary brain tumors suffer from insomnia symptoms. In addition to hypnotics, nonpharmacological interventions for insomnia in patients with brain tumors are still lacking. When using hypnotics may cause daytime sleepiness, cognitive impairment, and increase the risk of cancer, seeking an effective intervention is of clinical importance. Sensorimotor rhythm neurofeedback therapy has been shown to improve insomnia in different populations. However, its effect on insomnia has not been explored in patients with brain tumors. We, therefore, … |
HSIAO-YEAN CHIU; | 2022-09-01 |
| 263 | Predicting Delayed Cerebral Ischemia Using Micro- and Macrovascular Parameters in Subarachnoid Hemorrhage Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) results from a complex combination of macro- and microvascular processes. Besides cerebral vasospasms (CVS), DCI is caused by microthrombosis, neuroinflammation, microvascular dysfunction and cortical spreading depolarization.The glycocalyx plays an essential role in regulation of inflammation, oxidative stress and thrombosis, … |
MAASTRICHT UNIVERSITY MEDICAL CENTER | 2022-09-01 |
| 264 | Pilot Study to Evaluate Virtual Reality Exposure Therapy on People With Epilepsy and Related Anxiety Related Papers Related Patents Related Grants Related Experts View Highlight: Over 28% of people with epilepsy (PwE) struggle from at least one anxiety disorder, making anxiety the most common psychiatric comorbidity in this population. Despite the importance of treating anxiety in PwE, it has not received much research attention and is often unrecognized and untreated. Research has suggested that including exposure therapy (ET) as a part of an anxiety treatment may be helpful for decreasing anxiety in PwE. Research has also shown that Virtual Reality (VR) is an effective and helpful tool for delivering ET in a number of different types of anxiety disorders, such as posttraumatic stress disorder, … |
LORA APPEL; | 2022-09-01 |
| 265 | FMRI of Active DBS Stimulation in Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to use functional imaging to study the mechanisms of the anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS). |
STEVEN A. MESSINA; | 2022-09-01 |
| 266 | The Effects of Low Glycemic Index Diet on Epileptic Seizure Frequency, Oxidative Stress, Mental Health, and Health-related Quality of Life in Children With Drug-resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial was to evaluate the effectiveness of a low glycemic index diet (LGID) on seizure frequency, oxidative stress markers and quality of life in children with drug-resistant epilepsy. Based upon the aims, the following hypotheses were tested: 1. LGID reduces seizure frequency in children with drug-resistant epilepsy. 2. LGID improves oxidative parameters in children with drug-resistant epilepsy 3. LGID improves quality of life and mental health in children with drug-resistant epilepsy Participants were prescribed the LGID for 3 months.At baseline and at outpatient clinic follow-ups at 3 months, anthropometric measurements were taken, … |
GAMZE YURTDAŞ DEPBOYLU; | 2022-08-28 |
| 267 | A Pilot Study to Assess The Efficacy of Subanesthetic Doses of IV Ketamine in The Treatment Drug Resistant Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: Ketamine is a medication that came into clinical practice in the 1960’s. Ketamine is used as an anesthetic and to provide pain relief. Recently, Ketamine was approved to treat drug resistant depression using subanesthetic doses. In the hospital setting, intravenous anesthetic dosages are used to treat unrelenting seizures known as status epilepticus in comatose patients. Ketamine in subanesthetic doses has not been tried as a treatment for medication resistant seizures in the outpatient setting. This study would like to examine the effectiveness of subanesthetic ketamine in outpatients who suffer from drug resistant epilepsy. |
MADELINE FIELDS; | 2022-08-26 |
| 268 | The Role of Point-of-care EEG in The Pediatric Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The researchers investigate the use of a simplified electroencephalogram (point-of-care EEG) in the pediatric emergency department for children with impaired consciousness or an ongoing epileptic seizure (status epilepticus). In addition, the researchers will compare the simplified EEG with the conventional EEG in the epilepsy outpatient clinic. |
LEOPOLD SIMMA; | 2022-08-24 |
| 269 | Regenerating The Adult Human Brain Through Exercise PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions. Given this significant burden, effective treatments to prevent dementia and new disease modifying therapies are urgently needed. Regeneration of lost neurons with new ones (i.e., … |
JONATHAN RUSSIN; | 2022-08-20 |
| 270 | Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: About 30% of persons with epilepsy have seizures that do not respond to drugs. The ketogenic diet is an effective treatment option for them, but this high fat diet is strict and difficult to maintain. The properties of gliflozins, which often are used to treat type 2 diabetes, make them a potential replacement for the ketogenic diet. This pilot study will determine whether gliflozins induce ketosis and could be used to treat adults with epilepsy safely. |
KWEE L THIO; | 2022-08-17 |
| 271 | Effects of Oral Motor Therapy in Children With Cerebral Palsy ; A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: : CP is a neurodevelopmental condition. A set of irreversible impairments of movement and posture development, resulting in activity limitation. Acquired CP can be the outcome of a variety of issues that arise after the first 28 days of a baby’s existence. A CP diagnosis can now be made as early as 16 weeks. speech-language pathologists (SLPs) began collaborating with OTs and PTs for Infants and toddlers who also struggle with speech impediments, feeding and swallowing disorder. Oral motor exercises (OMEs), … |
HAFIZA SHABNUM NOOR; | 2022-08-16 |
| 272 | Effects of General Anesthesia on Brain Functional Connectivity and Cognition in Children With Potential Neurological Damage PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Postoperative Cognitive Dysfunction(POCD)is a common postoperative complications, existing clinical research focused on the adult patients, ignoring that the developing human brain with underlying neurological impairments may be at higher risk for cognitive impairment, so we need a prospective study, observe this kind of special groups in the brain structure and function of before and after general anesthesia, To determine the susceptibility to neurotoxicity of general anesthesia drugs. |
LAI JIANG; | 2022-08-15 |
| 273 | The Effect of Application of Vagus Nerve Stimulation on The Treatment Efficiency in Temporomandibular Joint Dysfunction Caused By Myofascial Pain Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Temporomandibular joint dysfunction (TMD) is a broad clinical picture involving the TMJ and its disc, masticatory musculature, ligament tissue, and autonomic nervous system (ANS). TMD symptoms include decrease or excessive increase in joint range of motion (ROM), clicking sound or crepitation in the joint, pain around the joint or muscle group, chewing and swallowing problems. Pain caused by MPS, trigger point, fatigue, limitation of ROM, and ANS dysfunction cause TMD. With the inclusion of habits such as clenching and bruxism, pain, … |
ALPER PERCIN; | 2022-08-15 |
| 274 | The Efficacy of Ketogenic Diet in Treating Pediatric Intractable Epilepsy and Its Relationship With Changes in Inflammatory Markers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the efficacy of a ketogenic diet in treating pediatric intractable epilepsy and to explore its relationship with changes in inflammatory markers. The investigators plan to recruit 59 participants with intractable epilepsy, 39 of whom will receive a combination of ketogenic diet and conventional antiepileptic drugs, while 20 will receive only conventional drugs. The study will assess the impact of the ketogenic diet on epilepsy control and inflammatory markers, hoping to discover new treatment strategies. |
DONGFANG LI; | 2022-08-11 |
| 275 | Neural Mechanisms of Spatial Representations Beyond The Self PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Spatial navigation is a fundamental human behavior, and deficits in navigational functions are among the hallmark symptoms of severe neurological disorders such as Alzheimer’s disease. Understanding how the human brain processes and encodes spatial information is thus of critical importance for the development of therapies for affected patients. Previous studies have shown that the brain forms neural representations of spatial information, via spatially-tuned activity of single neurons (e.g., place cells, grid cells, or head direction cells), and by the coordinated oscillatory activity of cell populations. The vast majority of these studies have focused on the encoding of self-related spatial information, … |
MATTHIAS STANGL; | 2022-08-06 |
| 276 | Effectiveness of An Epilepsy Educational Application for Self-management in Viet Nam: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a common neurological disease which effects all genders, ages and geographic regions. Self-management refers to the ability of the individual, in conjunction with family, community, and healthcare professionals, to manage symptoms, treatments, lifestyle changes, and psychosocial, cultural, and spiritual consequences of health conditions. Optimal self-management may improve self-efficacy, knowledge about epilepsy of people with epilepsy (PWE) and family, medical compliance and avoidance of seizure triggers. This study aims to determine the effectiveness of the epilepsy app for PWE to improve self-management |
MINH-AN THUY LE; | 2022-08-01 |
| 277 | Transcranial Magnetic Stimulation (rTMS) for The Treatment of Focal Refractory Epilepsy: Neuropsychological and Electrophysiological Evaluation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy as a brain disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory focal epilepsy. Today different ways of stimulation were used, the best protocol of rTMS in refractory focal epilepsy is under evaluation. The aim of our study is neuropsychological and electrophysiological evaluation before and after rTMS sessions, the results of rTMS will be compared with VNS outcome in patients, who undergoes VNS implantation after rTMS. |
COMENIUS UNIVERSITY | 2022-08-01 |
| 278 | Measures of Cortical Excitability in Patients With Post-traumatic Epilepsy, Traumatic Brain Injury Patients Without Epilepsy, and Healthy Controls: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To test whether measures of cortical excitability derived from motor cortex transcranial magnetic stimulation (TMS) in patients with traumatic brain injury reflect heightened excitability relative to healthy controls and whether such measures can be used to distinguish patients with post-traumatic epilepsy from patients with head trauma but no epilepsy |
PAVEL KLEIN; | 2022-08-01 |
| 279 | Clinical Interest of A Genetic Diagnosis in Early Infant Epilepsy, Paraclinical and Therapeutic Management, and Psychological Impact of Families PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the paraclinical and therapeutic interest of genetic diagnosis in early onset epilepsy. |
ANAÏS PHILIPPE; | 2022-08-01 |
| 280 | Traditional Healer-initiated HIV Counseling and Testing in South Africa PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this proposal is to conduct a pilot test of a program aimed at training traditional healers to conduct HIV testing and implementing HIV testing among people living in Bushbuckridge, South Africa. Pilot Healer-initiated HIV testing uptake and linkage to prevention services. Trust in allopathic health care and HIV stigma will be measured among participants at study enrollment and at month seven. Hypothesis: Healer-initiated HIV counseling and testing (HICT) will increase trust in allopathic health care and reduce HIV stigma. |
CAROLYN AUDET; | 2022-07-22 |
| 281 | Physiological-based Pharmacokinetics Approach to Determine The Extent of Drug Exposure of Antiseizure Medications During Pregnancy and Breastfeeding PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project focuses on anti-seizure medication (ASM) clearance and physiological factors determining blood concentrations in pregnant adult women with epilepsy and amounts of exposure to their unborn children and nursing infants. |
PAGE B. PENNELL; | 2022-07-20 |
| 282 | Obstetrical & Neurological Outcomes in Individuals With Epilepsy During Pregnancy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the pregnancy, delivery, neonatal, and epilepsy outcomes in individuals with epilepsy undergoing pregnancy at the Maternal and Infant Health Programs at the University Health Network – Sinai Health and followed for epilepsy at the Toronto Western Hospital Epilepsy Clinic. In particular, we are interested in the association between following recommended epilepsy management guidelines for pregnant individuals with epilepsy and those aforementioned outcomes. |
ESTHER BUI; | 2022-07-20 |
| 283 | Getting SMART for Pediatric Epilepsy (Sleep, Melatonin, and Research Trial, SMART) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the effect of melatonin for improving sleep in pediatric epilepsy. |
WANG-TSO LEE; | 2022-07-18 |
| 284 | Study of Neurological Aging Among People Living With HIV (SNAP) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, exposure-control cohort study of older adults living with HIV comparing the neurological status of those who have had HIV infection for a longer period of time (long HIV group) to age, gender, and community-matched comparison group who have had HIV infection for a shorter period of time (short HIV group). |
GRETCHEN BIRBECK; | 2022-07-06 |
| 285 | Comparison of Antidepressants in The Real-World: Retrospective Cohort Study Using Big Data PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to investigate medication utilization pattern and risk of adverse outcomes among commonly used antidepressants by using nationwide claims database, in order to assess overall clinical benefit of antidepressant therapy in real-world practice. |
PFIZER | 2022-07-04 |
| 286 | Clinical Evaluation of Interstitial Laser Thermal Therapy Under Continuous MRI Monitoring As A Minimally Invasive Treatment of Patients With Medically Unbalanced Partial Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Laser Induced Interstitial Thermal Therapy (LITT) is a minimally invasive procedure that uses the heat generated by a laser light (65°) to destroy brain lesions by coagulation leading to lesion necrosis under real-time MRI monitoring. The laser optical fiber is implanted into the lesion using stereotaxy. This technique, which can be performed under local anesthesia and on an outpatient basis, proved its efficacy and safety in the treatment of brain metastases for the first time in the world in 2006 (A. Carpentier et al, 2008, 2011). Since then, more than 5,000 patients have been treated in the USA, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-07-04 |
| 287 | Virtual Reality for Outpatient Cancer Pain Management: A Dosing Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a non-randomized, unblinded dose-titration study to evaluate different doses of virtual reality to impact moderate-to-severe pain in patients living with cancer. After consenting to participate, in addition to usual pharmacologic pain management, participants will receive 1 week of VR daily for 10 minutes per session, then 1 week of VR twice a day for 10 minutes per session, then 1 week of VR use as desired by the participants. |
HUNTER GRONINGER; | 2022-07-01 |
| 288 | Treatment of COVID-19 Post-acute Cognitive Impairment Sequelae (PASC) With Portable Brain Stimulation: A Double-blind, Randomized-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After almost 2 years of pandemic, the consequences of the post-COVID syndrome, or PASC (Post Acute-Sequelae of Sars-CoV-2), have become a major challenge in the management of affected patients, generating costs for health services. and insecurity regarding treatments for the sequelae, given the complex and still poorly understood pathophysiology of COVID-19. This troubling scenario raises important questions about the impact of COVID-19 on central nervous system sequelae, including the risk of cognitive decline in old age and progression to dementia. Therefore, … |
ANDRE R BRUNONI; | 2022-06-30 |
| 289 | An Open-Label, Safety Study for Previously Treated Vatiquinone (PTC743) Subjects With Inherited Mitochondrial Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to assess the safety of vatiquinone in participants with inherited mitochondrial disease who had prior exposure to vatiquinone in a PTC/BioElectron sponsored (previously Edison) clinical study or treatment plan. The study will continue until vatiquinone becomes commercially available or the program is terminated. |
PTC THERAPEUTICS | 2022-06-21 |
| 290 | A Neural Population Model-based Characterization and Modulation of Neural Oscillations Underlying Cognitive Control in Healthy and Depressed/Anxious Human Subjects Related Papers Related Patents Related Grants Related Experts View Highlight: This is a basic neuroscience study of modulating brain oscillations involved in cognitive control. We will record brain signals and stimulate specific regions of the brain in human participants who are undergoing monitoring for epilepsy surgery. It is not a clinical trial for treating any disease. |
ISHITA BASU; | 2022-06-20 |
| 291 | A First-In-Human (FIH) Study of Inhibitory Interneurons (NRTX- 1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective (seizure frequency). NRTX-1001 comprises human interneurons that secrete a neurotransmitter, gamma-aminobutyric acid (GABA). |
NEURONA THERAPEUTICS | 2022-06-16 |
| 292 | TBS Treatment for Treatment-Resistant Depression: A Randomized, Sham-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Depression is a highly disabling disease that is prevalent throughout the world. The treatments proposed and studied to date have shown to be partially effective in treating this condition. Neuromodulation strategies have been used as an alternative, especially for refractory and challenging cases. In this context, studies investigating the effectiveness of transcranial magnetic stimulation, including the theta burst stimulation (TBS) modality, have been increasing in number. However, there is still a lack of information seeking to explore the maximum effectiveness in the TBS modality. Therefore, the investigators developed a new stimulation protocol consisting of 3 TBS sessions per day, … |
ANDRE R BRUNONI; | 2022-06-06 |
| 293 | The Effect of Inspiratory Muscle Training on Respiratory Function, Balance and Functional Capacity in Trainable Mentally Handicapped Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The aim of this study was to examine the effect of inspiratory muscle training on respiratory functions, balance and functional capacity in trainable mentally disabled individuals. Methods: Within the scope of the study, 30 children, aged between 8 and 17 years, diagnosed with educable mental disabilities, were randomly divided into experimental and conventional physiotherapy rehabilitation program (CPRP) groups. Before and after the test, blood pressure, respiratory frequency, pulse oximetry heart rate and arterial oxygen saturation (SpO2) values, and Modified Borg scores for fatigue and dyspnea detection were recorded. Body composition analysis, respiratory function test, … |
HANIFE ABAKAY; | 2022-06-02 |
| 294 | Investigating The Effect Of Cognitive Rehabilitation On Cognitive Impairment Associated With Antiseizure Medications In Patients With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It is clear that studies on cognitive rehabilitation in epilepsy patients mostly focus on patients undergoing epilepsy surgery and are largely classified according to the type of epilepsy. The main purpose of this study is to determine whether cognitive impairments associated with antiepileptic drugs develop in epilepsy patients using neuropsychological tests and event-related potentials, and if such an impairment is present, to investigate whether cognitive rehabilitation is beneficial. |
OMER KARADAS; | 2022-06-01 |
| 295 | Electroclinical Correlation of Anxiety, Evidences From Intracerebral Recordings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anxiety disorders have the highest prevalence among mental disorders and cause considerable individual and financial costs. Current treatments do not relieve mental suffering of many patients. Understanding neurobiological mechanisms involved in pathological anxiety is a major scientific challenge. |
JÉRÔME AUPY; | 2022-06-01 |
| 296 | Metacognitive Therapy and Neuro-physiotherapy As A Treatment for Functional Movement Disorders – A Randomized, Observer-blinded Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with functional movement disorders (FMD) present with abnormal movements incompatible with symptoms of well-defined neurological disorders and are not associated with structural abnormality of the nervous system. FMD are very common. However, the pattern of care of these patients is highly inconsistent and most patients feel dissatisfied with the treatment they receive. One reason for this unsatisfactory scenario is that there are no generally accepted therapeutic guidelines for FMD. Therefore, treatment strategies are urgently needed. Recent neurophysiological studies suggest common underlying disease mechanism across FMD patients, particularly abnormal allocation of attentional resources. Conceptually, this calls for therapeutic approaches, … |
ANNE WEISSBACH; | 2022-06-01 |
| 297 | Intracranial Stimulation Mapping In Epilepsy -The InStim Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single group prospective study to determine the feasibility for generating brain maps that localize cerebral functions and inter-regional information flow in partial epilepsy in adult patients. |
ALEXANDER HERMAN; | 2022-06-01 |
| 298 | Risk Factors and Etiologies of Epilepsy in Urban and Rural Rwanda PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is one of the most common chronic brain disorders. Up to 85% of persons living with epilepsy (PwE) live in the developing world. In sub-Saharan Africa (SSA), … |
IEME GARREZ; | 2022-05-31 |
| 299 | Connectivity Alterations of Brain Network in LGG Patients After Levetiracetam Application at Short Term PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to analyze the connectivity alterations in brain networks of LGG patients with epilepsy who take levetiracetam at short-term preoperatively. |
BEIJING NEUROSURGICAL INSTITUTE | 2022-05-25 |
| 300 | Effects of Sodium Lactate Infusion in Patients With Glucose Transporter 1 Deficiency Syndrome (GLUT1DS) Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the effect of lactate infusion on epileptic discharges on EEG and seizure frequency in glucose transporter 1 deficiency syndrome (GLUT1DS) patients. |
RADBOUD UNIVERSITY MEDICAL CENTER | 2022-05-20 |
| 301 | A Study on The Non-face-to-face Care Using The Phone, Such As Counseling and Prescription, Temporarily Permitted During The COVID-19 Pandemic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study to confirm the non-inferior effectiveness on health outcomes of tele-counseling or tele-prescription, which was the first outpatient system applied to the actual medical sites in Korea during the coronavirus disease 2019 (COVID-19) pandemic. Researchers collect data using electronic medical records and questionnaires to patients and their caregivers who are continuously receiving outpatient treatment for epilepsy at a single center. The results of the study will be presented by comparing the health outcomes between the non-face-to-face care group and the usual care group. |
LEE SEUK; | 2022-05-16 |
| 302 | A Phase 3, Open-label Study of Adjunctive Ganaxolone (GNX) Treatment in Children and Adults With Tuberous Sclerosis Complex (TSC)-Related Epilepsy (TrustTSC OLE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 3, global, open-label extension (OLE) study of adjunctive GNX treatment in children and adults with TSC who previously participated in either Study 1042-TSC-3001 or Study 1042-TSC-2001 |
MARINUS PHARMACEUTICALS | 2022-05-16 |
| 303 | Functional Brain Mapping in Pediatric Neurosurgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We aim to determine the clinical utility of ‘dynamic tractography’: a novel method for visualizing electrical neural transfers that incorporates the underlying white matter tracts and supporting linguistic processing. We will also determine how well objective electrophysiology biomarkers will improve the prediction of language outcomes following epilepsy surgery. This project will ultimately optimize understanding of how the human brain develops its language network dynamics. |
EISHI ASANO; | 2022-05-16 |
| 304 | Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the feasibility and safety of using the ketogenic diet (KD) in children who sustained moderate to severe traumatic brain injury (TBI). The secondary objective is a preliminary evaluation of the outcomes of children who have had the standard of care plus the KD, compared to those with standard of care alone. Outcome measures for the secondary objective will include: need for ventriculoperitoneal shunt, duration of unconsciousness, need for any type of craniotomy, duration of post-traumatic amnesia, acute hospitalization length of stay, … |
LINDA KRACH; | 2022-05-16 |
| 305 | Assessment of Adults Epidemiological Characteristics of Status Epilepticus in The French West Indies and in French Guiana PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The justification of this prospective and multicenter study is based on the absence of published data concerning, status epilepticus (SE), a pathology which seems frequent in the French West Indies (FWI) and French Guiana, and whose etiological and prognostic characteristics are often mentioned or assumed but which remain to be demonstrated. The scientific interest lies both in the knowledge of the epidemiology of this pathology and in the identification of the main etiologies, in particular the underlying brain lesions. The morbidity of SE is significant, associating neurological disorders with impaired consciousness, respiratory, hemodynamic and cardiac rhythm disorders, … |
FLORIAN NEGRELLO; | 2022-05-15 |
| 306 | A Prospective Population-based Longitudinal Observational Cohort Study of Late-onset Epilepsy, and Subsequent Stroke and Dementia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There is not much known about why some people develop seizures in adulthood, but some researchers think that it might be a warning from the body to highlight something may be wrong with the brain. A small number of people with first seizure in adulthood go on to experience problems like stroke or dementia later in life. However, stroke and dementia are common diseases, so it is not know whether there is a real association between these conditions. When people develop their first seizure in adult life, this is sometimes called Late-Onset Epilepsy. The NeuroFrailty study, … |
JASMINE WALL; | 2022-05-05 |
| 307 | Evaluation Of A Mobile Messaging Service (Text And / Or Graphic) In Improving Adherence With Ensured Supply Of Anti-Seizure Medications In People With Epilepsy In Kilifi And Nairobi, Kenya PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This will be a behavioural intervention with no investigational medicinal product. The intervention will be a mobile messaging service that sends short messaging service (SMS) as texts or graphics to people with epilepsy to remind them to take their medication and to refill their prescription and educational messages to share important messages tackling stigma and tips to improve quality of life. The investigators will also engage peripheral health facilities where people with epilepsy (PWE) participating in the study go for ASM refills, in collaboration with the respective county departments of health, … |
SYMON M KARIUKI; | 2022-05-01 |
| 308 | Multicenter Comparison of Interictal High Frequency Oscillations As A Predictor of Seizure Freedom PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In drug-resistant focal epilepsy, interictal high frequency oscillations (HFO) recorded from intracranial EEG (iEEG) may provide clinical information for delineating epileptogenic brain tissue. The iEEG electrode contacts that contain HFO are hypothesized to delineate the epileptogenic zone; their resection should then lead to postsurgical seizure freedom. We test whether our prospective definition of clinically relevant HFO is in agreement with postsurgical seizure outcome. The algorithm is fully automated and is equally applied to all datasets. The aim is to assess the reliability of the proposed detector and analysis approach. |
UNIVERSITY OF ZURICH | 2022-05-01 |
| 309 | Neurocognitive Basis of Attention and Eye Movement Guidance in The Real World Scenes Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine the effects of electrical brain stimulation (EBS) on visual search in natural scenes in humans. |
AVNIEL GHUMAN; | 2022-05-01 |
| 310 | Quantification of The Immediate Impact of Weak Electric Fields on Brain Activity By SEEG Measurements in Drug-resistant Focal Epilepsy Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcranial current stimulation (tCS), a safe, tolerable technique employing weak currents (~ 1 mA) applied to the scalp, has been shown to be a promising technique in alleviating seizures in focal epilepsy patients. Although studies reveal a decrease in the epileptiform activity due to tCS, … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2022-04-26 |
| 311 | Study of Attentional Disorders in Patients Suffering From Idiopathic Generalized Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Attentional disorders have been reported in neuropsychological studies evaluating patients suffering from generalized idiopathic epilepsy, but the data are disparate (in terms of test protocol). We aim to describe attentional and executive function disorder in IGE thanks to the Epitrack scale, validated in this specific population. Our secondary objective is to study the dynamic of cortical activity during an attentional task (the ANT), in order to describe the alteration of cortical networks in epileptic patients presenting with attentional disturbance. |
PHILIPPE DERAMBURE; | 2022-04-26 |
| 312 | Effect of Treating Helicobacter Pylori Infection on Seizure Frequency in Children With Drug-Resistant Idiopathic Generalized Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Helicobacter pylori (H. pylori) infection is associated with several health problems. The role of H. pylori infection in epilepsy has been investigated in a few studies. To the best of our knowledge, there have been no previous studies on the effect of treating H. pylori infection on seizure frequency among children with drug-resistant idiopathic generalized epilepsy. This study aims to evaluate the effect of treating H. pylori infection on seizure frequency among children with drug-resistant idiopathic generalized epilepsy. |
MENA SAMY BASILY; | 2022-04-20 |
| 313 | Study of Maternal Pharmacokinetic and Placental Transfer of Levetiracetam PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypotheses: The treatment of epilepsy during pregnancy is difficult because of the risk of anti-epileptic drugs on the one hand and the risk of destabilization of epilepsy in the mother on the other hand. There is limited data on the pharmacokinetics (concentration study) and pharmacodynamics (efficacy and toxicity effects study) of levetiracetam in pregnant women. The few studies focus on few women and show very strong interindividual variability and a tendency to decrease total concentrations. Main objective: To develop a population pharmacokinetic model of levetiracetam during pregnancy. After the study, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-04-20 |
| 314 | Clinical Trial of Rechargeable Implantable Vagus Nerve Stimulation System for Refractory Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the performance and safety of the rechargeable implantable vagus nerve stimulation system in automatic mode, and the clinical efficacy and safety of the device in the treatment of drug-resistant epilepsy with all modes of stimulation turned on |
YE WU; | 2022-04-17 |
| 315 | Neurophysiological Mechanisms of Language Comprehension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators simultaneously record neural activity through intracranial electrodes that are implanted for clinical purposes (see subject populations). At the end of the sentence, the subjects have to indicate how they comprehended the sentence by selecting which of several pictures matches the sentence they just read. Behavioral measures that the investigators record and analyze are their response times to advance to each next word in the sentence, … |
MATTHEW J. NELSON; | 2022-04-08 |
| 316 | Adaptation of The Motor System to Experimental Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to measure the impact of an experimental pain on electromyography, kinematics of motion and motor cortical excitability. |
UNIVERSITE DU LITTORAL COTE D’OPALE | 2022-04-08 |
| 317 | The Effectiveness of Transcutaneous Electrical Nerve Stimulation of The Auricular Branch of The Vagus Nerve in Loss Weight and Improving The Quality of Life in Patients With Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcutaneous vagus nerve stimulation (TENS) involves stimulation of the left and/or right auricular branch of the vagus nerve with low-frequency electrical impulses. In recent years, the possibilities of using this technology in chronic conditions characterized by immune and metabolic dysregulation have been studied. The aim of this study is to investigate the effectiveness of TENS in reducing weight and improving quality of life in patients with various degrees of obesity. |
OXANA DRAPKINA; | 2022-04-04 |
| 318 | A Phase 3, Double-blind, Randomized, Placebo-controlled Trial of Adjunctive Ganaxolone (GNX) Treatment in Children and Adults With Tuberous Sclerosis Complex (TSC)-Related Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 3, global, double-blind, randomized, placebo-controlled study of adjunctive GNX treatment in children and adults with TSC-related epilepsy. The study consists of a 4-week prospective baseline phase, defined as the first 28 days following screening, followed by a double-blind phase consisting of a 4-week titration period (with 2 additional weeks allowed, if necessary, for tolerance) and a 12-week maintenance period. |
MARINUS PHARMACEUTICALS | 2022-04-01 |
| 319 | Development and Optimization of Transcranial Magnetic Stimulation (TMS) Combined With EEG/EMG As A Biomarker Predicting Response to Antiepileptic Drugs PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ιn the present study (BIOEPI), the following three hypotheses will be investigated: 1. The proposed TMS-EEG / EMG protocol (which includes software for calculating the cerebral cortex stimulation threshold) in combination with advanced signal analysis and data mining methods will allow the detection of the effect of antiepileptic drugs (AED) with different mechanisms of action (lacosamide & brivaracetam) in the Central Nervous System under healthy and pathological conditions (Epilepsy). 2. AED-induced changes in selected TMS-EEG / EMG features predict the clinical response of individual epileptic patients to AED. 3. AED-induced changes in selected TMS-EEG / EMG features may predict cognitive side effects. |
ARISTOTLE UNIVERSITY OF THESSALONIKI | 2022-04-01 |
| 320 | Protective Effects of Pre- and Post-biotics on Gut Inflammation, Microbiota Diversity, Epileptogenesis, and Quality of Life in Rett Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will examine the potential efficacy and safety of two pre- and post-biotics on markers for gut inflammation and intestinal microbiota ecology in patients with Rett syndrome. Moreover, this trial will search for possible effects on epileptogenesis and quality of life. |
CLAUDIO DE FELICE; | 2022-04-01 |
| 321 | Electroclinical Features of Sudden Unexpected Death in Epilepsy (SUDEP) : A Multi-center Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sudden unexpected death in epilepsy (SUDEP) is regarded as a leading cause of premature death in epilepsy patients. We aim to capture the whole process of SUDEP and near-SUDEP occurrence in patients with epilepsy, and expolre video-electroencephalograph (V-EEG) changes and marker. A Chinese multicenter study was carried out to determine electroencephalo-graph marker related to SUDEP to provide a scientific basis for the prevention of SUDEP in patients with epilepsy. |
LIU YONGHONG; | 2022-04-01 |
| 322 | A Multicenter, Open-Label, Single-Arm Study to Evaluate Long-Term Safety, Tolerability, and Efficacy of Brivaracetam in Study Participants 2 to 26 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to investigate the long-term safety, tolerability and efficacy of brivaracetam in pediatric study participants with childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE). |
UCB BIOPHARMA SRL | 2022-03-30 |
| 323 | Effects of Balneotherapy for Patients With Post-COVID Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled study is to evaluate the effects of balneotherapy (BT) and aquatic exercises in patients with post-acute COVID syndrome (PACS). The main question it aims to answer are: • Does BT and aquatic exercises alleviate some of the most prevalent features that characterize post-acute COVID syndrome? Participants allocated to the intervention group will undergo 3 weekly sessions of BT and aquatic exercises on alternate days in groups of 8 during 4 weeks. Prior the beginning of the intervention, … |
XAVIER NOGUÉS SOLAN; | 2022-03-29 |
| 324 | HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) -Post-Traumatic Epilepsy (PTE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-PTE, to improve the quality of life and cognitive function in Service Members, Veterans and civilians with post traumatic epilepsy (PTE). This study will also assess the ability of the HOBSCOTCH-PTE program to improve quality of life in caregivers of PTE patients and to reduce caregiver burden. |
BARBARA JOBST; | 2022-03-21 |
| 325 | AI-assisted CEEG Diagnosis of Neonatal Seizures to Optimize The Administration of Antiseizure Medication: A Multicenter, Randomised, Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective randomised clinical trial study to test an artificial intelligence (AI)-assisted continuous electroencephalogram(cEEG) diagnostic tool for optimizing the administration of antiseizure medication (ASM) in neonatal intensive care units(NICUs). |
CHILDREN’S HOSPITAL OF FUDAN UNIVERSITY | 2022-03-16 |
| 326 | A Multicenter Diagnostic Study on The Utility of AI-assisted Continue EEG Diagnosis of Neonatal Seizures PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A diagnostic accuracy study on Artificial intelligence assisted continue EEG diagnostic tool is to carried out comparing with manually EEG interpretation as the golden standard for neonatal seizure. |
CHILDREN’S HOSPITAL OF FUDAN UNIVERSITY | 2022-03-16 |
| 327 | Validation of An Italian Questionnaire of Adherence to The Ketogenic Diet: IKetoCheck PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The ketogenic diet (KD) represents an effective and safe non-drug treatment for drug-resistant epilepsy in pediatric and adult age based on normocaloric, hyperlipidic (80-90% of the daily energy), normoproteic and hypoglucidic dietary regimen. Adherence to treatment with KD is often difficult in the long term, for the patient and for caregivers, especially in adolescence. There are no tools in the literature other than monitoring ketonemia to measure adherence to the diet. A quality tool, validated by experts, on a large population, would allow for a more solid assessment of adherence to treatment, … |
VALENTINA DE GIORGIS; | 2022-03-16 |
| 328 | A Phase 2A/2B Placebo-controlled Randomised Clinical Trial to Test The Ability of Triheptanoin to Protect Primary Airway Epithelial Cells Obtained From Participants With Ataxia-telangiectasia Against Death Induced By Glucose Deprivation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study design: Parallel group, placebo-controlled, dose-escalation each 2 months for 12 months. Dose based on percent (%) of calculated caloric intake. Thirty participants will be randomised in blocks on a 1:1:1 ratio into one of three groups stratified by age (< 5 years, 5-10 years, > 10 years of age). Group 1: 10%, 20%, 35%, 35%, 35% (no placebo). Group 2: placebo, 10%, 20%, 35%, 35% Group 3: placebo, placebo, 10%, 20%, 35%. Primary endpoint: The percent cell death induced by glucose deprivation in cell culture. Secondary endpoints include: Scales for assessment and rating of ataxia, … |
DAVID COMAN; | 2022-03-15 |
| 329 | Study of The Prevalence of Autistic Traits in Angelman Syndrome, The Correlation With Cognitive Level, Epilepsy, With Socio-communication Skills and Parenting Styles PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational cross-sectional study is to establish the prevalence of autism spectrum disorder in children and adolescents with Angelman syndrome. The main questions it aims to answer are: – which clinical variables differentiate AS patients with and without Autism Spectrum Disorder between genetics, epilepsy, pharmacotherapy, behavioural problems, parenting style and parents’ perceived stress. – which clinical variables differentiate parenting styles and levels of perceived stress. We collect data from neuropsychological, speech therapy and physiotherapeutic assessments, during regular clinical follow-ups, regarding: cognitive development (Bayely Scales of Infant Development-III, Cognitive Scale) and adaptive behaviour; … |
MARTINA BAGGIO; | 2022-03-15 |
| 330 | Volumétrie Optimisée En Radiologie : Intérêt En IRM Cérébrale Pédiatrique Dans L’Exploration De L’épilepsie Focale PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicentre cross-sectional study with prospective recruitment comparing the detection rate of lesions on brain MRI without and with quantitative volumetry and T1 relaxometry information during the management of children with suspected focal epilepsy. |
BAPTISTE MOREL; | 2022-03-14 |
| 331 | Pilot Study of Add-On Fycompa (Perampanel)Treatment for Catamenial Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the proposed investigation is to carry out a pilot study of add-on perampanel (Fycompa) in women with perimenstural (C1) catamenial epilepsy. Perampanel, a noncompetitive AMPA receptor antagonist, is uniquely positioned to decrease progesterone receptor mediated excitotoxicity. This mechanism of action would allow a novel use of perampanel as an effective treatment of C1 catamenial epilepsy. |
KATHERINE ZARROLI; | 2022-03-09 |
| 332 | To Drive or Not to Drive? A Machine Learning Data Analysis Approach Among Stroke Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn more about who can continue driving a car after a stroke. The focus of this study is on the relationship between cognitive abilities and fitness-to-drive. Participants will be asked to perform an extended neuropsychological testing and a real life on-road test, conducted by a professional driving instructor. Feedback will be given to the participants on request. |
GÁBOR FAZEKAS; | 2022-03-01 |
| 333 | Comparison of Efficacy of Ketogenic Diet and ACTH Therapy Among Children With West Syndrome: A Pilot Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Children with West syndrome are prone to refractory seizures with poor neurocognitive outcome overall. The current standard of care consists of treatment with ACTH, but the grade of evidence is not high and not much RCTs are available. Ketogenic diet is an effective and well tolerated treatment option in drug refractory epilepsy and also in refractory west syndrome. In view of minimal side effects, … |
SHEFFALI GULATI; | 2022-03-01 |
| 334 | Add-on Clioquinol in Drug-resistant Childhood Epilepsy: An Exploratory Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this exploratory trial, the potential anti-seizure activity of clioquinol in a small cohort of adolescents with drug-resistant epilepsy will be examined. Subjects will be exposed to clioquinol add-on for a period of maximum 8 weeks (2 weeks low dose, 6 weeks higher dose). The main hypothesis of the study is that 30% of the included subjects will be responders and that the median seizure frequency reduction will be at least 30%. |
LIEVEN LAGAE; | 2022-03-01 |
| 335 | Exploratory Open-Label Study of Effects on Responsive Neurostimulator Activity After Intranasal Administration of Single Dose of Valtoco® to People With Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the magnitude and duration of reduction in RNS recorded Detections and Long Episodes following intranasal administration of Valtoco®. All participants will have been implanted and treated with an RNS system for clinical purposes and regularly upload Detection and Long Episode data on a regular basis as part of regular clinical treatment. Participants will come to the clinic and be administered a single dose of Valtoco® via nasal spray. RNS recorded Detections and Long Episodes before and after Valtoco® administration will be compared. This is a pilot study, so all outcomes are exploratory. |
MICHAEL PRIVITERA; | 2022-03-01 |
| 336 | Therapy of Age-related Macular Degeneration Through Training With The Medical Eye Trainer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: People with the disease age-related macular degeneration (AMD) are treated with the Medical Eye Trainer (MET) system to improve their vision. The training is carried out over 2 months. |
ROBERT HÖRANTNER; | 2022-02-28 |
| 337 | Non-invasive Vagus Nerve Stimulation (nVNS) in Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted at Children’s Healthcare of Atlanta, in Atlanta, Georgia for a total duration of 24 months. The electrical neuromuscular stimulation device used in this study is the VitalStim 400, … |
SUMIT VERMA; | 2022-02-22 |
| 338 | A Comparison Between The Effectiveness of Vestibular Versus Dual Task Training on Balance in Children With Diplegic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the study is carried out to identify If there is any difference between the effectiveness of Vestibular training and Dual task training on balance in children with Diplegic Cerebral Palsy. so in this study the sample will be divided into two equal groups, each group will recieve only one type of training ( vestibular training or dual task training ) the balance of the diplegic children will be assessed before and after using HUMAC balance system and pediatric balance scale , … |
AMIRA ASHRAF MAHMOUD MOHAMED; | 2022-02-20 |
| 339 | The Impact of Coronavirus Disease 2019 (COVID-19) Pandemic on Migraine Disorder, Tension Headache and Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already rapidly spread around the world as a pandemic after its first report in Wuhan, China on December 12th 2019 ( Holshue ML et al .,2019 ). As of December 27th 2020, there were more than 79.2 million confirmed cases and more than 1.7 million deaths caused by COVID-19 worldwide (WHO,2020). Migraine& tension headacheare considered one of the most disabling chronic neurological diseases, and patients with migraine or tension headache are particularly vulnerable to drastic negative impacts of the pandemic. From heightened levels of psychosocial stress, … |
BASTAWY AL FAWAL; | 2022-02-20 |
| 340 | Study Title: Evaluation of The 24/7 EEG™ SubQ System in Subjects With Uncontrolled Genetic Generalised Epilepsy Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a 12 week prospective, comparative investigation in subjects diagnosed with uncontrolled genetic generalised epilepsy (GGE) also known as idiopathic generalised epilepsy (IGE). The purpose of the study is to evaluate whether the 24/7 EEG™ SubQ system, a subcutaneous implantable device, will demonstrate seizure sensitivity approximating that of inpatient video-EEG monitoring with the standard 10-20 electrode system. |
NORMAN DELANTY; | 2022-02-15 |
| 341 | Testing The Efficacy of A Neuro-cognitive and Psychosocial Intervention Module in People With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with epilepsy, especially drug-resistant epilepsy, have a lot of cognitive & psycho-social issues. There is little evidence pertaining to the efficacy of the various cognitive-behavioral interventions and cognitive retraining modules used in epilepsy patients in the Indian context. The real value of these interventions needs further consolidation in terms of its assessment and efficacy. The available literature is scanned and having limitations in terms of assessment tool used, sample size, and also lacks a broader spectrum of psychosocial interventions used. In view of the above limitations, we plan to specially develop & test a Neuro-cognitive and psychosocial intervention module, … |
NEETU CHOUDHARY; | 2022-02-15 |
| 342 | Safety and Efficacy of Stereo-Electroencephalography Guided Thermocoagulation in Drug Resistant Focal Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Therapeutic thermocoagulation will be carried out in patients with drug-resistant focal epilepsy in cases where an epileptogenic zone is found and proven according to stereo-electroencephalography (SEEG) data. |
ANDREY A ZUEV; | 2022-02-07 |
| 343 | Preventive and Personalized Medicine (2021-2023) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a GWAS study that aims to identify possible candidate genes associate to epilepsy by exploring single nucleotide polymorphism (SNP) in a group of epilepsy, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with epilepsy |
ILDAR FAKHRADIYEV; | 2022-02-01 |
| 344 | Clinical Study on The Effect of Improving Sleep Quality on Cognitive Function in Patients With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is one of the common chronic diseases of the central nervous system. 30% to 40% of patients with epilepsy have varying degrees of cognitive impairment, which affects their quality of life. At present, the treatment of cognitive impairment in patients with epilepsy is relatively scarce, and the therapeutic effect is still not ideal. Recent studies have shown that sleep disorder is also an important factor causing cognitive dysfunction, … |
XIJING HOSPITAL | 2022-02-01 |
| 345 | Earbud Electrode Electroencephalography System – Initial Feasibility Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to characterize the ability of the NextSense ear-EEG device to detect pathologic electrographic signatures of epilepsy and physiologic signatures of sleep in subjects undergoing simultaneous inpatient continuous EEG monitoring, polysomnography, or ambulatory EEG monitoring at home. |
DANIEL WINKEL; | 2022-02-01 |
| 346 | Study of Metabolic Connectivity in Drug-resistant Temporal Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 18F-Fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET) has a high sensitivity for temporal lobe epilepsy (TLE), the most common form of focal epilepsy, with a detection range of 86-90% . Therefore, 18F-FDG PET is a useful tool to identify the epileptogenic zone (ETZ) in the inter-ictal phase of drug-resistant temporal epilepsy during pre-surgical evaluation . Based on stereotactic electroencephalography (SEEG) findings, a correspondence between electrical data and metabolic changes on PET was found at the group level by identifying four different patterns of TLE . As expected, hypometabolism was not limited to the EZ defined by SEEG, … |
ANTOINE VERGER; | 2022-02-01 |
| 347 | Use of Immersive Virtual Reality for Laceration Repairs in The Pediatric Emergency Department PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the clinical trial is to compare virtual reality to standard of care for laceration repairs in the pediatric emergency department. The main question it aims to answer is: -Does virtual reality decrease pain and anxiety scores compared to standard of care for laceration repairs in the pediatric emergency department? Participants who meet the age and other inclusion criteria will be enrolled by research staff. They will complete a brief paper survey along with their guardians and the provider doing the laceration repair. The surveys will be completed after the laceration repair is finished. |
EASTERN VIRGINIA MEDICAL SCHOOL | 2022-02-01 |
| 348 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-921352 As Adjunctive Therapy in Subjects With SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to assess the efficacy, safety, and pharmacokinetics of NBI-921352 as adjunctive therapy for seizures in subjects with SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE). |
NEUROCRINE BIOSCIENCES | 2022-01-31 |
| 349 | Evaluation of Episodic Memory and Accelerated Long-term Forgetting in Patients With Drug-resistant Focal Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Drug-resistant focal epilepsy (DRFE) is frequently associated with complications of varying severity that impair patient’s quality of life. Among these complications, cognitive disturbances and especially episodic memory difficulties, play a determinant part. Episodic memory can be defined as a function that allows the mental reconstruction of a past life episode, through complex associative mechanisms that link the vivid experience to its context of occurrence, called encoding context. It is a dynamic cognitive function, which calls on a widely distributed cerebral network, mainly involving the medial temporal lobe, particularly the hippocampus. Epilepsy could have a specific impact on this crucial network, … |
VICTORIA GUINET; | 2022-01-26 |
| 350 | Effects of Pelvic Floor Muscle Training and Electrostimulation on Women’s Quality of Life and Pelvic Floor Muscle Function in Stress Urinary Incontinence PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to evaluate and compare the effects of electrostimulation in addition to pelvic floor muscle training and pelvic floor muscle training alone on pelvic floor muscle (PFM) function, urinary incontinence and quality of life in women with stress urinary incontinence. The main questions are: What is the effect of electrostimulation combined with pelvic floor muscle training on pelvic floor muscle function, symptoms of urinary incontinence and quality of life in women with stress urinary incontinence? What is the effect of pelvic floor muscle training program on pelvic floor muscle function, … |
LITHUANIAN SPORTS UNIVERSITY | 2022-01-15 |
| 351 | SUPER-refractory Status Epilepticus After Cardiac Arrest: A Multicenter, Retrospective, Cohort Study of Dual Anti-glutamate Therapy With Ketamine and Perampanel PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Status epilepticus (SE) is found in 20-30% of patients in coma after cardiac arrest, is often refractory to medical therapy and is considered a negative prognostic factor. Intensity and duration of treatment of refractory and super-refractory post-anoxic SE pose the ethical dilemma between futility of treatments and, conversely, their premature suspension. A recent study by the Epilepsy Center of the San Gerardo Hospital has shown that patients with super-refractory post-anoxic SE and favorable prognostic indicators can achieve a good functional outcome in more than 40% of cases, if treated with intensive and protracted therapy. However, … |
SIMONE BERETTA; | 2022-01-15 |
| 352 | The Effect of Carnitine Supplementation on Cardiac Function and Lipid Profile in Patients With Drug Resistant Epilepsy on Ketogenic Diet PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary aim: Demonstrating the effect of carnitine supplementation on lipid profile and cardiovascular functions in patients with DRE on KD. Secondary aim: To highlight the effect of carnitine supplementation on efficacy of KD in seizure control. |
AIN SHAMS UNIVERSITY | 2022-01-03 |
| 353 | Characterization of Human Olfactory Amygdala Subregions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We aim to better understand the subregions of the human amygdala that receive direct projections from the olfactory bulb |
CHRISTINA ZELANO; | 2022-01-01 |
| 354 | The EAGLET Project: EEG Vs AEEG to Improve The Diagnosis of NeonataL Seizures and Epilepsy – A Randomised Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current project undertakes a prospective multicentre randomised controlled trial to evaluate whether full or continuous electroencephalography (cEEG) is superior to amplitude-integrated electroencephalography (aEEG) in the real time evaluation and diagnosis of neonatal seizures and in reducing time to treatment. At-risk new-born infants will be recruited on the participating neonatal intensive care units (NICUs) by trained specialist staff and will have 24 hours of EEG monitoring. |
RONIT PRESSLER; | 2022-01-01 |
| 355 | Epileptic Seizure in Epilepsy Patients After First-dose Inactivated SARS-CoV-2 Vaccination: A Self-controlled Case Series Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Objectives: Seizure attack is one of adverse effects of vaccination in epileptic patients, the risk of which after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculation was elucidated in the present study. Methods: A self-controlled case series study was designed to examine the association between vaccination and epileptic seizure. A total of 240 epilepsy patients were included who were vaccinated with inactive SARS-CoV-2 vaccines (Sinovac Life Sciences and Lanzhou Institute of Biological Products) and admitted to outpatient clinics from July 2021 to December 2021. Poisson analysis was performed to estimate the relative incidence rate of epileptic seizure in risk periods (day 1-7, 8-21 and 1-21 after first-dose vaccination) compared to basal level in control period. |
LIU YONGHONG; | 2022-01-01 |
| 356 | Investıgatıon Of The Awareness Of The Parents Of The Cerebral Palsy Children About The Disease, Physiotherapy And Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Parents of Cerebral Palsy (CP) children participate in treatments, education services and general medical check-ups; They have many responsibilities such as the use of drugs, devices, educational materials. Therefore, involving parents of CP children in the rehabilitation process provides a stronger rehabilitation service for their children. In the studies, it was stated that the active participation of the parents in the physiotherapy and rehabilitation process increases the success rate of the treatment and the participation of the parents plays a key role for the success of the physiotherapy and rehabilitation. |
HATICE ADIGUZEL; | 2022-01-01 |
| 357 | Clinical Validation of ZEEG, A Wireless EEG Recording System for Pediatric and Adult Patients With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the standard clinical electroencephalography (EEG) device with a new portable wireless EEG device, further referred to as zEEG, made by ZETO®. zEEG was designed to make EEG studies simpler, safer, more comfortable, faster, and less obstructive for the patient, also easier to set up for technicians. Wireless and battery powered, it uses the latest mobile technology. Contrary to the clinical EEG, … |
ZOLTAN NADASDY; | 2022-01-01 |
| 358 | Investigation Of The Effects Of Upper Extremity Robotic Rehabilitation On Upper Extremity Functions And Gait Parameters in Individuals With Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral Palsy is defined as the cause of movement and posture disorders and activity limitation that develops in the fetal or infant brain that has not yet completed its development. When the literature is examined, although upper extremity and lower extremity involvements are common in individuals with hemiparetic CP, treatment programs are mostly aimed at the lower extremities. However, studies report that the upper extremity is more severely affected than the lower extremities in individuals with hemiparetic CP and that upper extremity functions have an effect on walking. Although different treatment methods have positive effects, … |
MUSTAFA BURAK; | 2022-01-01 |
| 359 | Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the proposed study is to assess the feasibility of using the BrainSonix BX Pulsar 1002 low-frequency and Low-Intensity Focused Ultrasound Pulsations (LIFUP) in human subjects suffering from intractable temporal lobe epilepsy. The patients selected will already be scheduled to undergo surgery for resection of the temporal lobe, and the investigational therapy will be applied to the temporal lobe at least one day prior to its scheduled removal. The study is intended to provide preliminary evidence of safety, … |
DARIN DOUGHERTY; | 2022-01-01 |
| 360 | Opioid Based Analgesia Vs Non-opioid Analgesia for Oocyte Retrieval Procedure – A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It is unclear whether routine addition of opioids for analgesia during minor gynecological procedures is beneficial. In this single-center randomized single-blinded trial, the investigators aim to test the primary hypothesis that opioid-sparing anesthesia regimen including intravenous acetaminophen is non-inferior to a similar anesthesia regimen containing fentanyl in providing postoperative analgesia in women recovering from oocyte retrieval procedures for in vitro fertilization. The investigators also aim to assess the difference in incidence of patient-reported opioid related adverse-effects between the two groups, … |
ELENA FARLADANSKY; | 2021-12-05 |
| 361 | Multifocal Theta Burst Transcranial Magnetic Stimulation in Generalized Epilepsy Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to assess the efficacy of multifocal theta burst transcranial magnetic stimulation in the prevention of epileptic seizures in adult patients with generalized epilepsy. The main questions it aims to answer are: – How does multifocal continuous theta burst stimulation (cTBS) impact the frequency and severity of epileptic seizures? – Does cTBS influence the quality of life in patients with generalized epilepsy? – What is the safety and tolerability profile of the experimental multifocal cTBS protocol? |
PAVEL LEAHU; | 2021-12-01 |
| 362 | Electrophysiological Biomarkers During Invasive Monitoring of Mesial Temporal Lobe Epilepsy Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators plan to enroll individuals with medical temporal lobe epilepsy who are undergoing surgical workup with clinically implanted intracranial electrodes. The study intends to administer computerized memory tasks and stimulation during the intracranial Electroencephalography (EEG) monitoring period. |
ROBERT GROSS; | 2021-11-30 |
| 363 | A Single-arm Open-label Study to Investigate The Bioavailability and Skin Absorption of CBD and THC From GT4 Technology in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The bioavailability of cannabinoids differs greatly for different routes of administration. When applied topically to the skin, they are absorbed through the skin or hair follicles while interacting with receptors to provide localized effects. To gain more information on the potential of this route of administration in therapeutic applications, this open-label study will investigate the skin absorption and bioavailability of CBD and THC delivered trans-dermally. |
DAVID CROWLEY; | 2021-11-27 |
| 364 | The Influence of Comorbid Depression on The Prognosis of Patients With Newly-Diagnosed Epilepsy: A Prospective, Multi-center, Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. The prevalence of depression in patients with refractory epilepsy is about 60%. However, the early diagnosis is usually difficult due to the unclear mechanism and untypical clinical symptoms, and there are no extremely effective treatments for depression in patients with epilepsy until now. In this prospective, multi-center, cohort study, … |
SHANGHAI ZHONGSHAN HOSPITAL | 2021-11-24 |
| 365 | The Oslo Study of Visual Impairment After Stroke (StrokeVIS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Longitudinal, prospective, single-center observational study of visual impairment after stroke. Population: Patients admitted with acute ischemic stroke at the Regional Stroke Unit at Oslo University Hospital who are assessed to not have more serious neurological deficits than to be eligible for a prospective observational study of visual impairment. National Institute of Health Stroke Scale (NIHSS) will be used for screening of the patients eligible for the study with cut off of NIHSS 20. Based on the number of patients admitted to our center to include 120 patients in the StrokeVIS study. The study aims are: 1. To determine the prevalence of visual impairment in stroke patients in the acute phase and after 3 months. 2. To compare visual impairment in those treated with EVT and those not. 3. To determine the sensitivity and specificity of the Vision Screening Assessment (VISA) tool for detection of visual impairment in stroke patients. 4. To assess possible association between brain MRI lesions and visual impairment in stroke patients in the acute phase. 6) To assess any cognitive deficits at 3-month follow-up that could impact visual function. Inclusion criteria: 1. Acute ischemic stroke and NIHSS < 20 2. Age ≥18 years. 3. Written informed consent of the patient or oral informed consent witnessed by a doctor. Exclusion criteria: 1. NIHSS < 20 2. No willingness and ability of the patient to participate in all baseline and follow-up examinations. Duration of study participation: 3 months. |
ANNE HEGE AAMODT; | 2021-11-15 |
| 366 | Effect of Interactive Training on Strength and Coordination in Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: ABSTRACT: Purpose: To investigate the effect of interactive training on muscle strength and coordination in children with hemiparesis. Materials and methods: This study involved 30 children of both sexes with unilateral cerebral palsy aged ranged 8 up to 10 years. A designed physical rehabilitation program was given to both groups. furthermore, study group received a wii fit virtual reality-based program. Muscle strength, bilateral coordination, running speed and agility were assessed by using Bruininks-Oseretsky test of motor proficiency, 2nd edition (BOT-2) while hip and knee extensor strength were assessed by lafayette hand-held dynamometer pre and post treatment program. |
SHIMAA MOHAMED REFFAT; | 2021-11-10 |
| 367 | NYU Managing Epilepsy Well (MEW) Study: A Randomized Controlled Trial of Telephone-Based Support for People With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a two-arm randomized controlled trial to compare telephone-based depression self-management (UPLIFT) to telephone-based support groups (BOOST). A sample of 120 English- and Spanish-speaking people with epilepsy (PWE) with elevated depressive symptoms will be enrolled. Both interventions are 8-week programs delivered in one-hour weekly sessions to groups of about 6 participants. Changes in depressive symptoms, quality of life and seizures will be assessed over 12 months. The trial will also examine mediators and moderators of treatment effects. |
TANYA SPRUILL; | 2021-11-09 |
| 368 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study to Investigate Safety, Tolerability, Pharmacokinetics, and Efficacy of NBI-921352 As Adjunctive Therapy in Adult Subjects With Focal Onset Seizures (FOS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the safety, pharmacokinetics, and efficacy of three different doses of NBI-921352 versus placebo in adults with focal onset seizures |
NEUROCRINE BIOSCIENCES | 2021-11-08 |
| 369 | An Open-Label, Single-Dose, Pharmacokinetics Study of VALTOCO® With Open-Label Safety Period in Pediatric Subjects With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1/2a, open-label, single-dose, PK study of VALTOCO with open-label safety period in pediatric epilepsy subjects age 2 to 5 years. |
BEN RENFROE; | 2021-11-08 |
| 370 | Effects of Different Time Period of Standing Frame on Spasticity and Gait in Children With Spastic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral palsy is a neurological disorder with abnormalities in muscle tone, movement disorders and motor incapability. It attributes to harm to the growing brain. Cerebral approach including brain and its palsy referred to weakness and problems while using the muscles. It is characterized by way of the incapability to normally control motor features, and it has. the capacity to have an impact on the general improvement of a child with the aid of affecting the child’s capability to explore, talk, learn, … |
NOUMAN KHAN; | 2021-11-02 |
| 371 | Health, Economic Analysis and Clinical Aspects of A Pediatric Cohort With Severe Motor and Intellectual Disabilities in Enteral Nutrition With Dedicated Formula. A Case-control Retrospective Observational Study for The Management of Gastroesophageal Reflux: The Role of Fundoplication According to Nissen PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Nutritional difficulties are common in children with neurodisabilities and can be associated with malnutrition and gastrointestinal diseases, such as gastro-esophageal reflux disease (GERD) and constipation. Neurological disorders can be divided into two main categories: progressive (neurodegenerative, mitochondrial disease) and non-progressive (cerebral palsy) neurodisabilities; nature of the disorders can impair on the nutritional status of these children. In 2017, ESGHAN published guidelines with specific nutritional claims. Approximately 46%-90% of children with neurodisabilities suffer from malnutrition and an enteral feeding is necessary to reach the nutritional requirements. In addition, a relevant issue for these children is GERD, … |
BAMBINO GESÙ HOSPITAL AND RESEARCH INSTITUTE | 2021-11-01 |
| 372 | The Effect of Progressive Relaxation Exercises Applied to Patients With Epilepsy on Depression, Sleep and Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy; It is a disease characterized by sudden, repetitive, epileptic seizures that are not triggered by an identifiable event and occur as a result of abnormal and excessive electrical discharge in cortical neurons from ancient times to the present. It is known that epilepsy has important social and psychological effects. Seizure recurrence and fear of social exclusion are life-threatening factors for epilepsy patients. These difficulties negatively affect the quality of life of patients by causing high levels of anxiety, depression, sleep disorders and low self-esteem. Many positive effects of progressive relaxation exercises on anxiety, depression, … |
GÜLCAN BAHCECIOĞLU; | 2021-11-01 |
| 373 | Evaluating The Antidepressant Efficacy of Transcranial Magnetic Stimulation (TMS) in Patients With Inflammatory Bowel Disease (IBD) and Effects on IBD-related Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcranial magnetic stimulation (rTMS) has demonstrated diagnostic and therapeutic potential for a number of conditions and is an approved treatment for depression. Inflammatory Bowel Disease (IBD) has a significant impact on mental health, and comorbid maladaptive behaviors and pain are highly prevalent in patients with IBD and are often under-treated. The investigators predict TMS will improve comorbid maladaptive behavior (heightened interoceptive awareness, sleep, fatigue, catastrophizing, anxiety and depression), reduce pain and improve quality of life in persons with inflammatory bowel disease (IBD). Further, TMS benefits will be associated with changes in gut microbiome as measured by stool, … |
UNIVERSITY OF CALGARY | 2021-11-01 |
| 374 | Association of Brain Derived Neurotrophic Factor (BDNF) Rs6265 Gene Polymorphism With Susceptibility to Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a common neurological condition that affects people of all ages.Recent studies found that epilepsy is associated with several chromosomal regions, where mutations in these regions cause neurological dysfunction. BDNF which is the most ample neurotropic factor in the CNS, has survival and growth promoting roles in a variety of neurons. It has been shown to promote excitatory (glutamatergic) synapses while weakening inhibitory (GABAergic) ones. A nonsynonymous G to A single-nucleotide polymorphism (SNP) exists at position 196 of exon 2 (rs6265), which results in valine (val) to methionine (met) substitution. This polymorphism affects intracellular packaging of pro-BDNF, … |
SALMA KHALAF ABDELMAGEED; | 2021-11-01 |
| 375 | Thalamic Stimulation to Prevent Impaired Consciousness in Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: The goal is to provide a novel therapeutic option for temporal lobe epilepsy patients when focal impaired awareness seizures cannot be stopped by medications, surgical or laser ablation, or by neurostimulation. The goal is restore consciousness when seizures cannot be stopped. If successful, addition of bilateral thalamic stimulation to existing responsive neurostimulation to rescue consciousness would greatly alter clinical practice and patient outcomes. Importantly, previous approaches aim to stop seizures, … |
HAL BLUMENFELD; | 2021-10-31 |
| 376 | STARSTIM: SAFETY AND THERAPEUTIC MEASURES OF TRANSCRANIAL CATHODAL DIRECT CURRENT STIMULATION (TDCS) IN PATIENTS WITH REFRACTORY FOCAL EPILEPSY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers transcranial cathodal direct current stimulation (tDCS). Subjects will be treated with STARTSTIM or sham device for 10 sessions over a 2-week period. The subjects will be followed for an additional 10 weeks post treatment. Quality of Life questionnaires and adverse events will be collected and evaluated. |
NEUROELECTRICS | 2021-10-25 |
| 377 | Interest of Speech Therapy in Children With Epilepsy: What Impairments of Cognitive Functions? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Since the proportion of language and attentional difficulties in patients with epilepsy is recognized, both in the literature and in the clinical experience of practitioners, it is appropriate to propose a complete speech-language assessment of oral language and attention.This study investigates these impairments through the taking of specific tests. The general objective of this study is to observe possible oral language and attention disorders in children with epilepsy, … |
MAXIME COLMARD; | 2021-10-15 |
| 378 | Measuring Low-density Lipoprotein Particle Production and Clearance Rates in Response to Diet-induced Ketosis in Humans PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There have been concerning case reports of marked elevations of LDL-c in some individuals consuming a KD and Dr. Lewis has been referred a number of these cases to his lipid clinic, some of whom have had extreme elevations of LDL that mimic familial hypercholesterolemia. These marked elevations of LDLc are unique to a ketogenic diet and far exceed the typical mild elevations seen in those consuming a high fat, … |
GARY F LEWIS; | 2021-10-12 |
| 379 | Deep Brain Stimulation Surgery for The Treatment of Refractory Obsessive-Compulsive Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will include two parts. The first part will include two patients in a non-blinded, non-randomized, open trial. They will undergo Deep Bran Stimulation (DBS) for OCD (targeting the amSTN), as clinically accepted and approved in Israel (by the MOH) and in other countries in Europe and the US. The second part will include eight patients. This part will be an interventional, randomized, double-blinded clinical trial (patient and psychiatrist; … |
IDIT TAMIT; | 2021-10-12 |
| 380 | Community I-STAR Mozambique: Community Implementation of SBIRT Using Technology for Alcohol Use Reduction in Mozambique PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Hazardous drinking (HD) is a major public health burden worldwide with significant morbidity and mortality. To reduce HD, the World Health Organization (WHO) recommends using Screening, Brief Intervention, Referral to Treatment (SBIRT). Mobile health technology (mHealth), such as the mSBIRT app, is a promising tool for widespread cost-effective delivery of evidence-based HDS by community health workers (CHWs) because of its potential to increase fidelity, effectiveness, and sustainability. Community I-STAR Mozambique comprises three phases: 1) mSBIRT adaptation, 2) a cluster-randomized trial, and 3) scale-up of the most cost-effective intervention. Community I-STAR Mozambique will scale-up a cost effective, … |
MILTON L. WAINBERG; | 2021-10-01 |
| 381 | A Feasibility Study of Smartphone-based Brainwave Entrainment (BWE) Technology As A Novel Treatment for Chronic Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Is brainwave entrainment a feasible tool for managing long-term pain in a patient population in the home-setting? Long-term pain affects 4 in 10 people in the UK and can impact on all aspects of life. Many people find that their pain is not well controlled on the treatments that are currently available, or they experience unpleasant side-effects from painkillers. There is therefore an urgent need for new safe and effective treatments for long-term pain. One new approach to treatment is to target alpha brainwaves – … |
HELEN LOCKE; | 2021-10-01 |
| 382 | Investigation of The Effects of Yoga and Aerobic Exercise Training on Physical and Mental Health in People With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years, there is growing interest in illustrating the health benefits of exercise among epilepsy. Although exercise is recommended for patients with epilepsy, there is uncertainty concerning the effects of yoga and aerobic exercise on multiple health outcomes in epilepsy. The aim of this trial is to examine the effects of yoga and aerobic exercise training on physical activity, health-related physical fitness, mental, emotional, and psychological health status, seizure frequency and quality of life. |
BURCIN AKTAR; | 2021-10-01 |
| 383 | Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this project EEG recordings between healthy participants and those with a diagnosed Absence-epilepsy will be compared. The investigators suggest differences in EEG microstate analysis and neuropsychological parameters related to interictal cognitive impairment in these patients. This projects goal is to derive an EEG-based measure of conscious awareness. |
INKEN TOEDT; | 2021-10-01 |
| 384 | The Study on The Еffectiveness of The Integration of A Device Based on A Neural Interface and Neurostimulation of The Spinal Cord in The Rehabilitation of Patients With Upper Limb Movement Impairments Due to Neurological Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate the effectiveness of a new rehabilitation technology for paralysis that occurs after stroke or spinal cord injury. The research will jointly use a prototype neurorehabilitation orthosis, in which a robotic device moves a paralyzed arm at the command of a non-invasive brain-computer interface to perform a game life-like task augmented using a virtual-reality display, … |
MIKHAIL LEBEDEV; | 2021-10-01 |
| 385 | Digital Solution to Improve Cognitive Function in Epilepsy: PRODDIGE Project PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Epilepsy leads to cognitive impairment in 20-50%. Compared to seizures, these cognitive disorders are a major additional factor in occupational, social and family disability. Memory and language skills are most often impaired. These disorders are well described, multifactorial, but no therapy (drug and/or non-drug) has been validated to date. Recently, cognitive remediation techniques have shown benefits in certain neurological pathologies, such as multiple sclerosis. In adult epilepsy, … |
CENTRAL HOSPITAL NANCY FRANCE | 2021-10-01 |
| 386 | The Effect of Virtual Reality Distraction on Anxiety Level During Dental Treatment Among Anxious Pediatric Patients: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: This study evaluated the effect of Virtual Reality Distraction (VRD) on dental anxiety among anxious children undergoing prophylactic dental treatment by utilizing both subjective (Venham Anxiety and Behavioral Rating Scale (VABRS)) and objective (heart rate (HR) and salivary cortisol level (SCL)) measures. Method and Materials: This randomized controlled study included 36 6- … |
OSAMA M FELEMBAN; | 2021-10-01 |
| 387 | Impact of Interictal Epileptiform Activity on Some Cognitive Domains in Newly Diagnosed Epileptic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a common health problem worldwide. In general population, studies in developed countries estimated the annual incidence of epilepsy to be~50 per 100,000 and prevalence to be ~8.2 per 1,000. These figures are higher in developing countries in which prevalence of >10 per 1,000 was reported. In Upper Egypt, Assiut Governorate, the prevalence rate was 12.9 per 1,000. In people with epilepsy there is an associated high rate of cognitive difficulties that compromise educational progress and achievement throughout life. Approximately 1-5% of the population exhibits epileptiform discharges on electroencephalography (EEG). Interictal epileptiform discharges (IEDs), meaning spikes, polyspikes, sharp waves, … |
SHADY MOHAMED SAFWAT HASSAN; | 2021-09-30 |
| 388 | Interventional, Randomized, Double-blind, Crossover, Placebo-controlled, Multiple-dose Lu AG06466 Phase 1 B Study in Patients With Focal Epilepsy Using EEG and PSG to Investigate Its Pharmacodynamic Effects on Prolonged Period of Inter- Icterical Spikes, Sleep and Neuroinflammation Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to investigate effects of Lu AG06466 on seizure activity after increasing daily doses during 4 weeks in participants with an implanted responsive neurostimulation system. |
H LUNDBECK | 2021-09-29 |
| 389 | Postural Stability of Ambulatory Children With Cerebral Palsy After Robotic Assisted Gait Training Versus Body-Weight Supported Treadmill Training Objectives to Compare The Effect of Robotic-assisted Gait Training and Body-weight Supported Treadmill Training on Postural Stability in Ambulatory Children With Cerebral Palsy. Methods: A Randomized Control Study Involved Ambulatory Children With Cerebral Palsy With GMFCS Levels I, II and III. They Were Randomly Allocated to One of Two Locomotor Treadmill Training Groups. Postural Stability Outcomes Will Assessed Before and After The Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to explore the impact of gait training with a robotic device versus treadmill training on enhancing postural stability and walking capabilities in children with cerebral palsy (CP). The main questions to answer are children with CP who receive Robotic gait training will improve more in their postural stability compared with children with CP who received gait training on Treadmill? Are children with CP who receive Robotic gait training will improve more in their gross motor functions compared with children with CP who received gait training on Treadmill Are children with CP who receive Robotic gait training will improve more in their walking distance compared with children with CP who received gait training on Treadmill? Researchers will compare Group A to Group B to see if Robotic gait training has more effect on their outcomes than treadmill. Participants will be randomly allocated to one of two group and will receive gait training for 3 times per week for eight weeks. Outcome measures will be assessed in the base line before starting intervention and after completing intervention. Study Design A randomized control trial (RCT) Participants and Recruitment The trial will be conducted in Pediatric Out-Patient Rehabilitation Services (Clinic 750) at king Abdullah Specialized Children Hospital (KASCH), National Guard Hospital (NGH) in Riyadh, Saudi Arabia. The study populations are ambulatory children who have been diagnosed to have Spastic CP and who are referred and treated in rehabilitation department at KASCH in NGH in Riyadh. Recruitment will be through their medical record number. Inclusion Criteria are Spastic CP diagnosed from a pediatrician’s (Neurology clinic) to have Diplegia, Hemiplegia, or Quadriparesis, Both gender with their age ranged from 5-14 years, independently able to stand and walk or walk with assistance, GMFCS Level I and II, with walking limitations, but able to ambulate without the gait device for most distances and with GMFCS Level III, who have a greater degree of walking limitation and able to use wheelchairs or walkers for short to long distances, Ability to follow instructions, Ability to accurately signal pain and discomfort using verbal or non-verbal signals, Ability to be participated in > 45 minutes of active Physical Therapy treatment, Hip’s and knee’s passive range of motion (ROM) within the minimum range requirement for robotic device (≤10° for hip and knee flexion contracture). Exclusion Criteria are Botox injection in lower limb during the last 6 months, Surgical intervention in lower limb within a 1-year period prior to the examination date (including tendon release, muscle lengthening and bone surgery), Active drug for resisting epilepsy, Anatomical leg length differences larger than 2 cm (due to the limitations of robotic device), Bone-articular instability (joint dislocation), Fixed joint contractures; bone and joint deformities of lower extremities, Baclofen therapy by using an implanted infusion pump, Inhibiting casts for lower limb during 6 months prior to the program, Significant visual and hearing loss, Skin inflammation and open skin lesions around the lower limb or trunk, Any significant impairments in endurance due to limitation in cardiovascular system based on the patient’s history, Cognition (higher mental functions) disorders resulted in lack of patient cooperation, Lack of consent from the parent or guardian. Procedure We will send the invitation letter to the parents of participants. If interested, we will provide their parents with the informed consent (written). We will obtain the Assent from children who are unable to provide independent consent. Then, the participants will complete a basic screening session. If the participant met the eligibility criteria of the screening, he/ she will have a robotic device fitting assessment session to confirm there are no concerns with the participation in the study and to use the robotic device. If the participant met these the fitting criteria, the therapist would review the findings and will confirm (with the family) whether the child is eligible for the study based on their findings. The participants will be divided randomly to enter on of the two treatment groups (robotic or treadmill). Each participant will have a baseline assessment during the first two weeks prior to the beginning of the treatment, treatment program for eight weeks, and post treatment assessment at the last two weeks after completing the program. The duration of the whole program is twelve weeks. All participants will be assessed for their balance and walking parameters. |
MOZAINAH YAHYA ALJOUSH; | 2021-09-25 |
| 390 | The Impact of Sexual Intercourse on Spontaneous Onset of Labor PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Women included in our study were recruited for a randomized trial on the effect of sexual intercourse to promote the onset of spontaneous labor. For this analysis, our sample was divided into two groups by randomization. The first group (experimental) followed the protocol (sexual intercourse 1 day out of 2 alternating with nipple stimulation alone for 15 minutes three times a day) for 2 weeks. In the control group, … |
ACHOUR RADHOUANE; | 2021-09-24 |
| 391 | EpiWatch: Evaluation of A Non-EEG Physiological Signal Based Seizure Monitoring System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To demonstrate the safety and effectiveness of the EpiWatch device in identifying tonic-clonic (TC) seizures, notifying a third-party of TC seizure occurrence, and collecting non-EEG physiological data for subsequent review during patient hospitalization in an epilepsy monitoring unit (EMU). |
GREGORY L KRAUSS; | 2021-09-20 |
| 392 | An Interactive Web-based Decision Aid for Shared Decision Making: Birth Choice After Cesarean in Taiwan PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An interactive web-based decision aid for shared decision making: birth choice after cesarean in Taiwan Background: Taiwan has a high national caesarean rate coupled with a low vaginal birth after caesarean (VBAC) rate. Studies suggest that pregnant women do not receive sufficient information about birth choices after caesarean in Taiwan and shared decision making (SDM) is not an expectation. Chen conducted a pilot study. Improvements in knowledge for the decision aid group were larger than for the usual care group, … |
SHE WEN CHEN; | 2021-09-15 |
| 393 | The Effect of Progressive Relaxation Exercises on Fatigue and Sleep Quality in Individuals With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim: It was conducted to determine the effect of web-based animation supported progressive relaxation exercise on fatigue and sleep quality in individuals with epilepsy. Material and Methods: As a randomized controlled study with a pretest- posttest model, it was conducted with individuals with epilepsy who applied to Giresun University Faculty of Medicine Neurology Outpatient Clinic between February and December 2022.The sample of the study was determined as 60 epilepsy patients, 30 of which were in the control-30 experimental group, using power analysis. The data were collected by face-to-face interview technique using Personal Information Form, Pittsburg Sleep Quality Index, … |
NEŞE İŞCAN AYYILDIZ; | 2021-09-10 |
| 394 | Inhalational Ethanol Therapy (Spray and Nebulized ETHO) in COVID-19 Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cytokine storm is the cause of many deaths in COVID -19. The antiviral in-vitro effects of ethanol with solving the fat layer and destroying the glycoprotein of coronavirus have already been established. Proven antiviral effects of ethyl alcohol on extracellular surfaces have been demonstrated by researchers. Immunological studies have shown that acute administration of ethanol can have immunomodulatory effects on innate immunity system mediated by TNFamRNA protein and mitogen-activated protein kinas and reduce cytokine storm by reducing inflammatory factors such as -TLR, TLR, TL-9, … |
ALI AMOUSHAHI; | 2021-09-02 |
| 395 | Integrating A Stepped Care Model of Screening and Treatment for Depression Into Malawi’s National HIV Care Delivery Platform PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Malawi is a low-income country in sub-Saharan Africa that has limited resources to address a significant burden of disease-including HIV/AIDS. Additionally, depression is a leading cause of disability in the country but largely remains undiagnosed and untreated. Lack of cost-effective, scalable solutions is a fundamental barrier to expanding depression treatment. Against this backdrop, one major success has been the scale-up of a network of more than 700 HIV clinics, with over half a million patients enrolled in ART. As a chronic care system with dedicated human resources and infrastructure, this presents a strategic platform for integrating depression care, … |
RAND | 2021-09-01 |
| 396 | A Study Protocol for An Online Intervention to Promote School Engagement Through Gamification in Children With Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral Palsy (CP) is a neurological, non-progressive, and permanent developmental disorder that mainly affects movement and posture, with a prevalence of 3 to 4 children per 1000 live births. CP’s motor impairments are often accompanied by disturbances of sensation, perception, cognition, communication, and behavior. These impairments echo in the activities of daily life, as well as in the learning process. Importantly, children with CP are especially prone to display working memory and EFs deficits, as well as difficulties in self-regulation, … |
SÍLVIA LOPES; | 2021-09-01 |
| 397 | Acute Recording of Stereotyped High-Frequency Oscillations with A Closed-Loop Brain Interchange System in Drug-Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange – BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, … |
NURI F. INCE; | 2021-09-01 |
| 398 | Efficacy of Melatony Versus Sleep Deprivation for EEG Recordings in Sleep: A Randomized Crossed-over Study in Pediatric Patients With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the pediatric population, electroencephalographic (EEG) recordings are frequently performed in sleep, as it reduces the amount of artifacts and might activate epileptiform discharges. To date, no agreed-upon guidelines are available for hypno-induction for EEG recordings . Among the strategies used, the most commonly used are sleep deprivation, either total or partial, and the use of melatonin, alone or in combination. The investigators proposed a study aiming at evaluating the efficacy of a melatonin-based solution for sleep induction during EEG video recording VS sleep deprivation. In a randomized, crossover study, … |
VALENTINA DE GIORGIS; | 2021-09-01 |
| 399 | A Pilot, Single Blind, Randomized Crossover Study to Evaluate The Safety and Efficacy of NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and efficacy of using NaviFUS™ system in patients with drug resistant epilepsy |
NAVIFUS | 2021-09-01 |
| 400 | A Post Marketing Study to Evaluate The Safety and Efficacy of Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring A Reduction in Ethanol Use Related Papers Related Patents Related Grants Related Experts View Highlight: This is the first clinical trial of Endourage OMD 1200 for persons desiring to reduce their alcohol consumption. |
THOMAS P YOUNG; | 2021-09-01 |
| 401 | A Dose-Ranging Safety, Tolerability, and Exploratory Efficacy Study of Adjunctive EQU-001 for Seizures in Adults With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double-blind, placebo controlled, randomized study of dose-ranging safety, tolerability, exploratory efficacy of adjunctive EQU-001 for seizures using the continuous reassessment method in patients diagnosed with epilepsy. |
EQUILIBRE BIOPHARMACEUTICALS B V | 2021-08-31 |
| 402 | Anti-Seizure Medications Withdrawals After 2 Years of Seizure Remission PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The proper period of anti-seizure medication (ASM) treamtment is important for decreasing side effect of ASM and recurrence of seizure. We evaluate reliable risk factor analysis for safe withdrawal of ASM in children with epilepsy. Futhermore, we develop the scoring system for prediction of seizure recurrence to set the standard for safe withdrawal of ASM. |
MIN-SUN YUM; | 2021-08-30 |
| 403 | A Non-Drug, Longitudinal, Prospective Natural History Study of Individuals With KCNT1-Related Epilepsy (K1Te) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to characterize seizures in participants with KCNT1-related epilepsy. The secondary objectives are to characterize head growth, symptom severity, neurocognitive and social functions, adaptive behavior, sleep, quality of life, caregiver burden, and mood in participants with KCNT1-related epilepsy. |
BIOGEN | 2021-08-17 |
| 404 | Bilateral Continuous Theta Burst Stimulation of Cerebellum for Drug-refractory Epilepsy: A Double Blind, Randomised, Single Centre, Crossover Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to observe the effect and safety of cerebellar continuous θ burst stimulation (cTBS) for drug-refractory epilepsy(DRE), in order to provide a new treatment for DRE and improve the quality of life of those patients. A total of 44 patients with DRE will have cTBS via accurate navigation to bilateral cerebellar dentate nuclei. Patients will be randomised into 2 groups in a crossover trial design to have 2 week periods of cTBS separated by 8 week washout periods, … |
XIJING HOSPITAL | 2021-08-02 |
| 405 | Comparison of The Postoperative Analgesic Effects of Ibuprofen Versus Ketorolac in Patients Undergoing Orthopedic Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: To compare the postoperative analgesic effects of ibuprofen versus ketorolac in patients undergoing orthopedic surgery at Combined Military Hospital, Rawalpindi. Study design: Randomized controlled trial Setting: Department of Anasthesiology, Combined military Hospital, Rawalpindi Duration of study:6 months (01st August 2021 to 31st January 2022) Material and methods: After ethical approval, 100 patients in randomly divided two equal groups (A and B) were selected. In group A, 800 mg IV ibuprofen while in group B, … |
FAZAL HUSSAIN SHAH; | 2021-08-01 |
| 406 | Priming The Epileptic Brain – Determining The Effect of Temporarily Addition of Transcutaneous Vagal Nerve Stimulation When Starting An Add-on AED (in This Case Brivaracetam) in Patients With Refractory Focal Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The most prevalent neurological disorder with also immense burden of disease, epilepsy, is in over 30 percent of patients difficult to treat. The ideal treatment regime would give complete control of disease in an early stage, not only for patient well-being, but also to prevent the onset of persistent pathologic epileptic networks in the brain. The first step in treatment is the trial, and error, of multiple anti-epileptic drugs (AEDs), … |
MARIAN M MAJOIE; | 2021-08-01 |
| 407 | A Randomized, Dose-Finding and Confirmatory, Double-Blind, Placebo-Controlled, Parallel-Group Multicenter Study With A 2 Stage Adaptive Design and Randomized Withdrawal to Evaluate The Efficacy, Safety, and Tolerability of Brivaracetam As Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to test the efficacy, safety and tolerability of brivaracetam monotherapy in study participants 2 to 25 years of age inclusive with childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE). |
UCB BIOPHARMA SRL | 2021-07-29 |
| 408 | Exercise for Memory Rehabilitation in Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine how effective a 6-week exercise program is for improving memory compared to a no-intervention control group, investigate the brain changes that may be responsible for memory improvements, and determine if the memory benefits and brain changes are retained 6 weeks after completing the exercise intervention in people with Idiopathic generalized epilepsy (IGE). |
JANE ALLENDORFER; | 2021-07-21 |
| 409 | Contribution of Genetics, Non-invasive Neurophysiological Methods, Neuroimaging and Neuropsychology in Identifying The Cause and The Epileptogenic Zone in Focal Cryptogenic Epilepsies Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with cryptogenic focal epilepsy (unknown cause) represent about the 30% of the entire population of epilepsy patients. Among them, about 30% are drug-resistant. The implementation of of high-field magnetic resonance imaging resolution, the new Next Generation Sequencing techniques,and innovative non-invasive neurophysiological methods (Electroencephalogram-Functional magnetic resonance imaging and High Density-Electroencephalogram) could provide a superior identification of the epileptogenic zone and therefore an increased access to epilepsy surgery. Despite this, patients with cryptogenic epilepsy require more frequently invasive methods of presurgical study and they have more unfavorable results than patients with lesions detectable on magnetic resonance imaging. Within this context, … |
STEFANIA ZAMBRANO; | 2021-07-15 |
| 410 | Pediatric Language and Memory Mapping in Refractory Epilepsy Using Magnetoencephalography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot research study where language and working memory tasks will be used to study brain activities from children with epilepsy. Specifically for language assessment, a well-known MEG language protocol will be used and novel signal processing techniques will be applied. A widely utilized paradigm will be used to study memory function and adapt signal-processing techniques from previous literature for the processing and analysis of MEG signals collected during memory task. No treatment/intervention will be performed or evaluated in this pilot research study. |
DIANA I ESCALONA-VARGAS; | 2021-07-14 |
| 411 | Gamma Oscillations and Working Memory Following Combined 40Hz TACS and ITBS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the present studies is to develop and validate novel stimulation protocols for the entrainment of gamma oscillations, which are associated with many cognitive functions and critically involved in cognitive impairment such as Alzheimer’s disease. In this proposal, combination of repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS), which has been shown effective for the induction, and stabilisation of alpha and theta frequencies in our forgoing studies, will be adopted to the gamma frequency range and applied on prefrontal regions as well as model-based cortical areas to enhance and stabilize gamma oscillations, thereby facilitating cognition |
MOHAMMAD ALI SALEHINEJAD; | 2021-07-13 |
| 412 | Avaliação Do Desenvolvimento Adaptativo A Longo Prazo Após A Cirurgia De Epilepsia Em Crianças E Adolescentes Farmacorresistentes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Our interest in studying how pediatric patients develop after epilepsy surgery stems from the fact that difficult-to-control epilepsy causes changes in the brain’s formation or functioning, leading some patients to experience slower development compared to others. By gaining a better understanding of how pediatrics patients fare after epilepsy surgery, specifically regarding their independence in daily activities (such as bathing or making the bed), their relationships with family and friends, their mobility, and their speech (whether it is understandable) we can learn more about patient recovery. The goal of this research is to determine whether, 4 years after epilepsy surgery, … |
ANA VALERIA DUARTE OLIVEIRA; | 2021-07-07 |
| 413 | Effectiveness of Functional Magnetic Stimulation and Pelvic Floor Muscle Training on Pelvic Floor Muscle Function, Urinary Incontinence Symptoms and Quality of Life in Women With Stress Urinary Incontinence PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to evaluate and compare the effects of functional magnetic stimulation and pelvic floor muscle training on pelvic floor muscle function, urinary incontinence symptoms and quality of life in women with stress urinary incontinence. The main questions it aims to answer are: – What is the effect of functional magnetic stimulation on pelvic floor muscle function, symptoms of urinary incontinence and quality of life in women with stress urinary incontinence? – What is the effect of pelvic floor muscle training program on pelvic floor muscle function, … |
LITHUANIAN SPORTS UNIVERSITY | 2021-07-07 |
| 414 | A Multi-center, Real-world Clinical Study of Perampanel As An Add-on Treatment for Epileptic Seizures in Chinese Children PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-center, real-word clinical trial. The purpose of this study is to evaluate the safety and effectiveness of perampanel as an add-on treatment for epileptic seizure, and to find the effective maintenance and maximum dose in Chinese children. The enrolled subjects were epilepsy patients between 2 and 12 years of age who had failed clinical treatment with 1-3 anti-epileptic drugs (AEDs) with the optimal dose and course of treatment and needed additional treatment. The study was a real-world prospective clinical study, … |
XIAODAN LI; | 2021-07-02 |
| 415 | Investigation of Serum Antimullerian Hormone Levels in Adolescent Epilepsy Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The production of AMH starts in granulosa cells before birth and the levels within the serum decreases towards the menapouse. The levels of AMH do not change throughout the menstruation cycle hovewer, it can be affected in cases related to body mass index (BMI), polycyctic ovarian syndrome (PCOS). The lower levels of AMH had been documented after ovarian surgery, radiotheraphy and chemotheraphy. AMH is a member of Transforming Growth Faktor β (TGF- … |
ALI CENK; | 2021-07-02 |
| 416 | Clinical Efficacy and Safety of Perampanel Monotherapy in The Treatment of Children With Focal Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project is a multicenter prospective study. By retrieving outpatient medical records and collecting clinical data of epilepsy patients, the efficacy and safety of single-drug perampanel in patients with focal epilepsy were analyzed. |
YANG XINWEI; | 2021-07-01 |
| 417 | Genetics of COVID-19 Risks & Resilience in Bipolar Disorder As Subproject of BIPGEN (Genetic Changes in Bipolar Disorder) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: BIPGEN is a cross-sectional study on the genetics of bipolar disorder. As a subproject of BIPGEN, BIP-COVID is a cross-sectional genetics study about risks & resilience in the COVID-19 (Coronavirus disease) pandemic in bipolar disorder (BD) and healthy controls at the Medical University of Graz. Study participants with BD and controls from the well-established BIPLONG and BIPGEN studies will undergo a special BIP-COVID visit, which will include a COVID-19 specific online Lime survey about the psychological burden in the COVID-19 crisis, a COVID-19 antibody test (IgM and IgG), … |
EVA REININGHAUS; | 2021-07-01 |
| 418 | Treatment of Acute Post-stroke Oropharyngeal Dysphagia With Paired Stimulation Through Peripheral TRVP1 Agonists and Non-invasive Brain Stimulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: According WHO, oropharyngeal dysphagia (OD) is a prevalent post-stroke (PS) condition involving the digestive system (ICD-10: I69.391) and an independent risk factor for malnutrition and pulmonary infection; and leads to greater morbimortality and healthcare costs and poorer quality of life (QoL). Currently, OD therapy is mainly compensatory, with low rates of compliance and small benefit, and there is no pharmacological treatment, so new treatments that improve patients’ condition are crucial. PS-OD patients present both oropharyngeal sensory and motor deficits, … |
PERE CLAVE; | 2021-07-01 |
| 419 | Clinical Trial Data Set Re-use With Statistical Methodologies Tailored for Clinical Trials in Rare Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberous sclerosis complex (TSC), affecting 1 in 6.000 live births, is characterized by the development of multisystem tumors. Seizures are frequent up to 80% of individuals. They usually start in infancy and are often drug resistant, with a high risk of intellectual disability and autism spectrum disorders. In animal models, preventive treatment before seizures onset significantly decreased the risk of epilepsy as well as associated comorbidities. EPISTOP randomized clinical trial (RCT) aimed to validate the effect of preventive therapy in patients with TSC diagnosed before clinical seizures with abnormal EEG, versus late standard therapy of epilepsy, … |
RIMA NABBOUT; | 2021-07-01 |
| 420 | Electrophysiologic Brain Sensing Using Implanted DBS Systems in Neurological and Psychiatric Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: High-frequency deep brain stimulation (DBS) is an effective treatment strategy for a variety of movement disorders including Parkinson’s disease, dystonia and tremor1-5, as well as for other neurological and psychiatric disorders e.g. obsessive compulsive disorder, depression, cluster headache, Tourette syndrome, epilepsy and eating disorders6-11. It is currently applied in a continuous fashion, using parameters set by the treating clinician. This approach is non-physiological, as it applies a constant, unchanging therapy to a dysfunctional neuronal system that would normally fluctuate markedly on a moment-by moment basis, depending on external stressors, cognitive load, … |
PATRICIA LIMOUSIN; | 2021-07-01 |
| 421 | Development of Adaptive Deep Brain Stimulation (aDBS) for The Treatment of Intractable Obsessive-Compulsive Disorder (OCD) Phase II Using Summit RC+S System With ECoG Paddles Related Papers Related Patents Related Grants Related Experts View Highlight: This research study is for participants that have been diagnosed with intractable Obsessive -compulsive disorder (OCD). OCD is a persistent and oftentimes disabling disorder marked by unwanted and distressing thoughts (obsessions) and irresistible repetitive behaviors. OCD affects 2-3% of the US population, … |
WAYNE GOODMAN; | 2021-07-01 |
| 422 | The Effect of Yoga on Sleep and Quality of Life in Epilepsy Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Determining the sleep quality and quality of life of epilepsy patients and offering solutions can be effective in their success both in their professional and social lives. Therefore, in this study, it was aimed to evaluate the effectiveness of yoga therapy on sleep quality and quality of life in epilepsy patients. |
ZÜLFÜNAZ ÖZER; | 2021-06-30 |
| 423 | The Effect of Laughter Yoga on Nurses Psychological Resilience and Sleep Quality During The Pandemic Period PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to determine the effects of laughter yoga on the psychological resilience and sleep quality of active nurses during the pandemic period. Initial stage of labor on randomized controlled birth outcomes and maternal satisfaction. A total of 100 nurses, determined by power analysis, were recruited into the randomized controlled, single-blind clinical study. The study included 2 groups (group A nurses who had active contact with patients diagnosed with or at risk of covid-19, group B: nurses who had active contact with patients diagnosed or at risk of covid-19 and participated in laughter yoga practice. Laughter yoga; … |
SUHEYLA YARALI; | 2021-06-24 |
| 424 | Multimodal Study for The Diagnosis and Treatment of Drug-resistant Focal Epilepsies PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a clinical condition that affects about fifty million people worldwide, with an estimated occurrence of 16-51 new cases per 100,000 people each year. In 60% of these patients, the origin of seizures is due to a localized (focal) alteration of the brain. In about 25 percent of patients with focal epilepsy, drug treatment is ineffective, a condition defined by the International League Against Epilepsy (ILAE) as drug-resistant epilepsy ; … |
FONDAZIONE I R C C S ISTITUTO NEUROLOGICO CARLO BESTA | 2021-06-23 |
| 425 | Effect of The Format of A Video Game on Children’s Experience During Venipuncture PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anxiolysis and analgesia are of paramount importance when conducting medical procedures, particularly in children. Nonpharmacologic techniques such as distraction and hypnosis improve the patient experience when used in the correct setting and may reduce the need for medications and pharmacological sedation. Virtual reality immersion is a novel approach to anxiolysis and analgesia but the content (i.e. games) available on the market are limited in their appropriateness for age, and the lack of specific design for medical procedures. VRelief, designed using a multidisciplinary team of clinicians, hypnosis practitioners, … |
CYRIL SAHYOUN; | 2021-06-21 |
| 426 | Anesthesia of Endolaryngeal Laser Surgery and Perioperative Side Effects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators analyze the anesthesia of the endolaryngeal laser surgery in patients with smoking with or without monitoring of depth of anesthesia (bispectral index) |
TIMEA BOCSKAI; | 2021-06-18 |
| 427 | The Effect of Laughter Yoga on Nurses’ Perceived Stress Burnout and Life Satisfaction During The Pandemic Period: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to determine the effects of laughter yoga on the perceived stress, burnout and life satisfaction of nurses working actively during the pandemic period. A total of 120 nurses, determined by power analysis, were included in the randomized controlled study. The study included 2 groups. (A group of nurses who have active contact with patients diagnosed with or at risk of covid-19, group B: nurses who have active contact with patients diagnosed with or at risk of covid-19 and participate in laughter yoga practice. Laughter yoga; … |
TÜLAY KILINÇ; | 2021-06-15 |
| 428 | Prediction of Recovery in Spastic Cerebral Palsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Until now, for children with cerebral palsy (CP) , diagnostic and some prognostic predictive machine learning studies have been conducted, but prognostic studies targeted specific milestone according to specific gross motor function measure (GMFCS) levels; such as walking and running predictors at GMFCS II and III and GMFCS II respectively, … |
IMRAN AMJAD; | 2021-06-14 |
| 429 | Structural Cartography of The Insula in Temporal Epilepsy Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy. |
TYVAERT LOUISE; | 2021-06-01 |
| 430 | Leveraging The Gut Microbiota in Pediatric Refractory Epilepsy: Safety and Feasibility of Oligofructose-enriched Inulin Supplementation for Dysbiosis and Seizure Control PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Nearly a third of children with epilepsy are refractory to pharmacotherapy. The ketogenic diet (KD) is a highly effective alternative therapy reducing seizure frequency by 50% in more than half of treated children. The exact mechanisms of KD remain poorly understood, and recent studies have implicated the gut microbiota (GM). This pilot study aims to determine the feasibility of a 12-week dietary intervention with prebiotic fiber in children with epilepsy. The investigators hypothesize that consumption of inulin will alter gut microbiota and may have effects on seizure frequency. |
MAKSIM PARFYONOV; | 2021-06-01 |
| 431 | A Feasibility Study to Evaluate PDE MAX, A Food for Special Medical Purposes (FSMP) for Use in The Dietary Management of Pyridoxine Dependent Epilepsy (PDE) With Regards to Acceptability, Tolerability, Adherence and Effect on Metabolic Control PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: PDE MAX is a single arm prospective, feasibility study in up to 15 participants aged one (1) year and over of PDE MAX for the dietary management of Pyridoxine Dependent Epilepsy. |
CLARA VAN KARNEBEEK; | 2021-06-01 |
| 432 | Antidote for Valproic Acid Toxicity: A New Indication for Meropenem Antibiotic. A Randomized Placebo-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute Valproic acid (VPA) toxicity is an emergency condition which may commonly present with central nervous system (CNS) depression(5). In mild poisoning, associated with VPA ingestions of 200 mg/kg, sedation and lethargy commonly occur(6); while in severe VPA poisoning associated with ingestions of 400 mg/kg or more, life threatening events are likely to occur as respiratory depression, metabolic acidosis, encephalopathy, hemodynamic instability, and cerebral edema which may progress to coma and even death -if not treated promptly. Supportive care along with early gastric decontamination using activated charcoal (AC) (which may only be given if patient presented early after ingestion), … |
NANCY MOHAMED; | 2021-06-01 |
| 433 | Darbepoetin in Neonatal Encephalopathy (EDEN) Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypoxic Ischemic Encephalopathy is also known as ‘birth asphyxia related brain injury’ and happens when the brain does not receive enough oxygen or blood flow around the time of birth. Birth asphyxia related brain injury is the most common cause of death and neurodisability in term babies. Cooling therapy has substantially improved the outcomes of babies with HIE. However, … |
THAYYIL SUDHIN | 2021-05-28 |
| 434 | Transcranial Direct Current to Treat Epilepsy at Home PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a placebo-controlled study of the effectiveness of transcranial direct current stimulation (tDCS) at home to reduce seizures and EEG spikes. |
ROBERT S FISHER; | 2021-05-26 |
| 435 | Self-management for People with Epilepsy and A History of Negative Health Events (SMART): Targeting Rural and Underserved People with Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: SMART is a program for adult individuals with sub-optimally controlled epilepsy. It involves educational and behavioral interventions intended to enhance epilepsy self-management. The group sessions are conducted remotely over the teleconferencing application, Zoom. These sessions are held over an 8 week time period and are co-lead by a trained nurse educator and a trained peer educator. The peer educator is someone with epilepsy and a history of NHEs. Educators use a written curriculum delivered online, and the interactive sessions last 60-90 minutes. Groups are limited to about 6 -12 adult participants. After the group sessions are done, … |
MARK A. GRANNER; | 2021-05-19 |
| 436 | Safety and Efficacy of CBD (Epidiolex) in Idiopathic Generalized Epilepsy With Typical Absence Seizures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Pilot study, open-label study consisting of a screening period of up to 4 weeks, a 4-week dose-titration treatment period to dose of up to 20 mg/kg/day BID of CBD (Epidiolex), and a 30 day safety follow-up period following the last dose of study medication. |
SELIM BENBADIS; | 2021-05-11 |
| 437 | A Non-interventional Study Describing The Healthcare Resource Utilisation and Clinical Outcomes Associated With LivaNova Vagus Nerve Stimulation Therapy in The UK PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a UK, multi-center, non-interventional study based on the use of health service administrative and medical records (paper-based and/or electronic, as applicable) along with the use of prospectively collected subject-reported outcomes on experience with use of VNS therapy using validated and bespoke self-completion questionnaires. Data for hospital resource utilisation will be extracted from the Hospital Episode Statistics (HES) database. |
MIKE CARTER; | 2021-05-11 |
| 438 | Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing The Efficacy and Safety of Sialanar Plus OrAl RehabiLitation Against Placebo Plus Oral Rehabilitation for ChIldren and Adolescents With SeVere Sialorrhoea and Neurodisabilties, PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Double blind, placebo-controlled, randomised trial, multicentre in France with open-label tolerability phase. The double-blind placebo-controlled study duration will be scheduled for 3 months with the final visit of the double-blind period at D84. After the D84 assessment, patients will be invited to continue into a 6-month openlabel study extension (OLSE) with ex-Sialanar® patients continuing the treatment and ex-placebo patients starting Sialanar® |
PIERRE FAYOUX; | 2021-05-10 |
| 439 | Testing of Identification Markers for Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is the third leading cause of death and the first cause of physical disability and dementia worldwide. Ischemic stroke caused by large vessel occlusion (LVO) is responsible for the vast majority of deaths and disabilities. A very effective and safe treatment, called mechanical thrombectomy (MT) is available for LVO patients. Nevertheless, no blood biomarkers able to identify LVO patients rapidly and to direct them to CT angiography and thrombectomy currently exist. The TIME study is an observational prospective cohort study. All Patients referred to the emergency department or stroke unit with a suspected stroke as identified by paramedics, … |
SHASHANK SHEKAR; | 2021-05-01 |
| 440 | A Multicenter, Open-Label Study to Evaluate The Pharmacokinetics, Tolerability, and Safety of A Single Dose of Staccato Alprazolam in Adolescent Study Participants With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess the pharmacokinetics (PK), tolerability, and safety of Staccato alprazolam in adolescent study participants with epilepsy following single-dose administration. |
UCB BIOPHARMA SRL | 2021-04-28 |
| 441 | Evaluation of The Effect of Early Administration of Neuroprotective Drug (Cerebrolysin) on The Outcome of Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Stroke is the third major cause of death and disability worldwide. It was shown that combining early reperfusion therapy (thrombolysis and/or thrombectomy) with stroke unit care and immediate rehabilitation have beneficial effects on the patient recovery and outcomes. Cerebrolysin that was proven to have s neuroprotective and neurotrophic effects in vitro and in vivo, … |
KLAUDYNA KOJDER; | 2021-04-27 |
| 442 | Evaluation of The 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients with Epilepsy Involving The Temporal Lobe Region. An Open-label, Prospective, Paired, Comparative Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The 24/7 EEG™ SubQ system will be compared to simultaneously recorded video-EEG in the Epilepsy Monitoring Unit (gold standard) and to self-reported seizure log books throughout 12 weeks of outpatient EEG recording. The present study is a 12-week open-label, prospective study with a paired, comparative design for pivotal evaluation of the safety and effectiveness of the 24/7 EEGTM SubQ system in subjects with epilepsy involving the temporal lobe region . 2-5 sites in Europe Up to 10 sites in US |
MICHAEL GELFAND; | 2021-04-21 |
| 443 | Investigation of Probiotic Effect on Seizure Frequency of Adult Patients With Drug-resistant Epilepsy; A Randomized Double-blind Parallel Placebo-controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, double-blind parallel group placebo-controlled clinical trial with the aim of investigating the effect of probiotic versus placebo on drug-resistant adult patients with epilepsy. |
NASIM TABRIZI; | 2021-04-21 |
| 444 | Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is a common neurological disease, manifested in the sudden abnormal discharge of neurons leading to short-term brain dysfunction, has become the neurology after headache the second most common disease. In China, the prevalence of epilepsy is about 4.7-8.5 per 1,000, and more than 400,000 new cases of epilepsy are developed each year. Of these, 30% of patients were treated with ineffective medication, developing into a drug-incurable epilepsy that required surgery and other treatments. The most common type of epilepsy is temporal lobe epilepsy, while the common complication in temporal lobe epilepsy is hippocampal sclerosis, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2021-04-19 |
| 445 | A Qualitative Study of Contraceptive Choice and Decision-making Among Adolescent and Young Adults Living With Chronic Illness and Medical Complexity: A Focus on Long Acting Reversible Contraception (LARC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators aim to perform a qualitative study exploring attitudes and perceived barriers to Long Acting Reversible Contraception (LARC), both implants and IUDs, among adolescent and young adults (AYA) with chronic illness at CHLA. While the literature examining barriers to LARC uptake is growing, its focus has been on older women and women who are not living with chronic illness. There remains a significant gap in the understanding of: 1. What adolescents and young adults from ethnically diverse, … |
CLAUDIA BORZUTZKY; | 2021-04-16 |
| 446 | Tracking The Efficiency of MyMind BrainHero® Personalised Neurofeedback in Patients With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study investigates the feasibility and the effects of training at home with personalised neurofeedback in children with an autism spectrum diagnosis and comorbidities. The personalisation relies on quantitative electroencephalography recordings performed in a clinic, which are also used to evaluate the efficiency of the home-based training, along with standardized questionnaires. The active phase is expected to last roughly 6 months, during which children are expected to complete multiple hours of training and complete an interim evaluation. Whether the training’s effects are long lasting is evaluated in a follow-up phase, 3 months after the active phase. |
NEDJELJKA BALDASS; | 2021-04-14 |
| 447 | A Telehealth Physical Exercise Intervention for The Treatment of Drug Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to determine whether a 12-week telehealth aerobic exercise intervention is feasible in people with epilepsy. The study team will also gather information on the effect of the intervention on sleep and stress as mediators of seizure frequency, well as effects on epilepsy and epilepsy associated comorbidities. |
HALLEY ALEXANDER; | 2021-04-13 |
| 448 | Effects of Vitamin D Supplementation on Depression and Inflammatory Markers in Adolescent and Youth With Major Depression and Vitamin D-deficiency: A Partially Randomized Preference Trial in Taiwan PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current study is designed as a prospective partially randomized patient preference (PRPP) trial and recruit psychiatric outpatients or inpatients. Participants who agree to receive randomization will be randomly assigned into a supplementation or placebo group, after stratification for pre-intervention vitamin D status (12-20 ng/mL or <12 ng/mL) and depression status (HDRS-17 ≥ 17 or < 17). Participants who decline randomization but agree to receive follow-up in the observational cohort choose their preferred method (either 4800 IU vitamin D3 per day, or usual care without supplementation). Severity of depression, any change of medication, ... |
SHEN-ING LIU; | 2021-04-12 |
| 449 | Transcranial Direct Current Stimulation on Inhibitory Control in Addictions: A Triple-blinded, Sham-controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The research in neuroscience of the last 20 years is defined, in addition to continuing to advance in the field of behavioral and pharmacological therapy, by the birth and development of a new therapeutic category, called neuromodulation. Neuromodulation offers the possibility of producing changes in the Nervous System (SN) and therefore, in behavior, in addition to lasting over time. One of the most used non-invasive neuromodulation techniques is transcranial direct current stimulation (tDCS). The benefits of tDCS are promising and varied, so it is a potential neurorehabilitation tool, … |
FERNANDO SANCHEZ-SANTED; | 2021-04-05 |
| 450 | Evaluation of Genetic Etiology in Patients With Cerebral Palsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral palsy (CP) is a permanent disorder of movement or posture due to non-progressive impairments of the developing brain. Current estimates indicate that as many as 30% of CP cases may be genetic in nature. In our study, the investigators will re-examine the data of children with CP, who are registered in the Slovenian National Registry of Cerebral Palsy. All children will be invited to the University Children’s Hospital, University Medical Centre Ljubljana, where they will be re-examined by a neurologist. Blood for genetic testing will be taken. In the case of confirmed genetic ethiology of CP, … |
DAMJAN OSREDKAR; | 2021-04-01 |
| 451 | NEED: Neuromed Epilepsy EEG Database. A Large Database of Electroencephalographic (EEG) Signals of Epilepsy Patients for Research Community PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: For one-third of patients with drug-resistant epilepsy alternative approaches must be investigated in order to improve the quality of their life. A possible approach is to find automatic methods to detect/predict seizures, in order to adopt interventional actions to stop or abort the seizure or to limit its side effect. The main problem in this case is to evaluate the reproducibility of such methods and to standardize them, because there is a lack of availability of long-term electroencephalography (EEG) data. In this study we want to create a large long-term EEG database, called NEED (Neuromed Epilepsy EEG Database), … |
LUIGI PAVONE; | 2021-04-01 |
| 452 | Multidisciplinary Expert System for The Assessment & Management of Complex Brain Disorders PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through comprehensive, cost-efficient, and fast protocols towards improving diagnostic accuracy and therapeutic outcomes in people with Complex Brain Disorders (CoBraD), as reflected in Neurocognitive (Dementia), Sleep, and Seizure (Epilepsy) disorders and their interdependence. It brings together internationally recognized experts in medicine, engineering, computer science, social health science, law, and marketing and communication from across Europe, and combines clinical information and scientific research in CoBraD with technical innovation in secure data-sharing platforms, … |
NEUROLOGICAL INSTITUTE OF ATHENS | 2021-04-01 |
| 453 | Clinical Audit on Evaluation of Patient With Syncope at Asssiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of commitment of resident physician to the guidelines as regard management of cases of syncope at Assiut University Children Hospital and correction of the defect that will be discovered. |
ASSIUT UNIVERSITY | 2021-04-01 |
| 454 | Prospective Non-randomized Single-arm Trial of Efferent Neuromodulation of Autonomic, Immune and Gastrointestinal Systems By VNS in The Epilepsy Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vagal nerve stimulation is a neurosurgical procedure consisting of implantation of an impulse generator battery with leads placed into the vagus nerve in the neck. This procedure was FDA approved for epilepsy in the 1990s and is commonly performed as an outpatient surgery. The mechanism of efficacy is not well understood; however it is increasingly recognized that electrical stimulation of the vagus nerve may impact other organ systems in the body including the immune, gastrointestinal and autonomic systems. The primary objective of this study is to characterize the pre- … |
IAN MUTCHNICK; | 2021-04-01 |
| 455 | Efficacy of Mefloquine As Prophylaxis Against COVID-19: A Placebo-control, Randomized Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the efficacy and safety of Mefloquine as a prophylaxis against SARS-Cov-2 infection in household contacts of COVID 19 confirmed. This study is an open-label, randomized, placebo controlled trial. A total of 1500 household contacts of COVID-19 confirmed cases who will attend triaging clinic of 5 Egyptian university centers (Helwan university hospital, Ain Shams university hospital, Assiut University Hospital, … |
MOHAMED EL KASSAS; | 2021-03-28 |
| 456 | Adjunctive ES-481 for Uncontrolled Glioma-Associated Epilepsy and Assessment for Potential Anti-Tumorigenic Effect in Patients With Isocitrate Dehydrogenase 1 (IDH1) Mutant Tumors Related Papers Related Patents Related Grants Related Experts View Highlight: Phase 2A single-arm exploratory clinical study in up to 12 adult subjects aged 18 and older with primary glioma, IDH1 mutation, and uncontrolled focal-onset seizure activity to determine the potential efficacy, safety and pharmacokinetics of ES-481 as adjunctive therapy in glioma-associated epilepsy and to assess for potential anti-tumorigenic effects. |
TERENCE O’BRIEN; | 2021-03-25 |
| 457 | Early Feasibility Study on Epios Leads PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Epios early feasibility study aims to explore the uses of novel sub-scalp lead devices in the detection of epileptic seizures. Epios leads are inserted subcutaneously through dedicated tunneling toolkits and have been designed for continuous EEG recording in inpatients. This clinical investigation is part of a stepwise program to validate the entire Epios system and it starts with the validation of the Epios leads alone in this two steps study. |
MAXIME BAUD; | 2021-03-23 |
| 458 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder and Multiple Chemical Sensitivity Compared to Healthy Controls – The Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Functional somatic disorders (FSD) are frequent in all medical settings and characterized by persistent physical symptoms that cannot be explained by other somatic or psychiatric conditions. In recent decades, a number of different types of functional somatic disorders have been defined, but so far there is no clear explanation for the pathophysiology. The high prevalence of olfactory problems in some patients with FSD suggests that olfactory symptoms are a potential diagnostic biomarker, especially in patients with multiple chemical sensitivity (MCS). The olfactory system is a unique sense with direct pathways to the limbic system, … |
LISE GORMSEN; | 2021-03-23 |
| 459 | A Pragmatic Trial of HOme Based Self-management & COgnitive Training CHanges Lives (HOBSCOTCH) in Georgia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to answer the question: Will a home-based self-management program, HOBSCOTCH, be effective in improving quality of life and perceived difficulties in cognitive abilities by teaching problem-solving strategies? The research team is also looking at a new mobile application that was developed to go with the program, and looking at extra booster sessions to improve long-term outcomes. In order to learn about the effectiveness of the program, … |
NGOC CAM ESCOFFERY; | 2021-03-17 |
| 460 | Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Premature Ventricular Contractions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized control trial is designed to explore the effect of low-level tragus stimulation in patients with frequent premature ventricular contractions. |
CHEN MINGLONG; | 2021-03-15 |
| 461 | Dietary Intervention for Psychotic Disorders: A Pilot Intervention Study of Ketogenic Diet for Psychotic Symptoms – PsyDiet Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Disturbances in glucose metabolism and glutamate neurotransmission feature in the pathophysiology of psychotic disorders. Ketogenic diet (KD) is a high-fat, low-carbohydrate diet that restricts glucose and forces metabolism of ketones, which serve as alternative energy substrates for the brain. KD is an established treatment for intractable epilepsy. However, we lack the randomized controlled trials (RCT) evidence regarding potential effects of KD on psychotic symptoms in humans. This randomised, controlled pilot study aims to investigate: 1. feasibility of a Modified Ketogenic Diet (MKD) intervention protocol in psychotic inpatients, 2. potential impact of MKD intervention on psychotic symptoms, depressive and anxiety symptoms, … |
ANU RUUSUNEN; | 2021-03-15 |
| 462 | Personalized Multichannel Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epilepsy: Evaluation of Therapeutic and Neurophysiological Effects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to conduct a pilot study based on the targeting of the epileptogenic zone previously localized very precisely by stereoelectroencephalography (SEEG). SEEG is used as part of the pre-surgical assessment. It consists, thanks to the intracerebral implantation of electrodes in the brain of patients, to perform an intracerebral electrophysiological recording and thus to precisely explore the epileptogenic regions. In order to study the neuromodulatory and therapeutic effects of tDCS on epileptic brains, non-invasive techniques for measuring electrophysiological brain activity such as magnetoencephalography (MEG) and high-resolution electroencephalography (HR EEG) will be used. Finally, … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2021-03-15 |
| 463 | The Effectiveness of The Education Program Based on The Individual and Family Self Management Theory Given For Epilepsy Adolescents and Parents: Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study; to determine the effect of education program given to adolescents diagnosed with epilepsy and their parents based on Ryan and Sawin’s individual and family self-management theory, on adolescents ‘attitudes towards disease, self-efficacy, quality of life and parents’ nurse-parent support levels. |
HILAL KURT; | 2021-03-11 |
| 464 | Open-Label, Single-Arm, Multicenter Study to Evaluate Long-Term Safety and Tolerability of Brivaracetam Used As Adjunctive Treatment in Pediatric Study Participants With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the long-term safety and tolerability of brivaracetam. |
UCB BIOPHARMA SRL | 2021-03-11 |
| 465 | The Epileptic Heart – Multiparametric Cardiac Magnetic Resonance Imaging for Detection and Quantification of Acute and Chronic Cardiac Involvement in Patients With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to use multiparametric cardiac MRI to identify any abnormalities in myocardial structure and function in patients with epilepsy. A two-stage study design is planned as part of the study: 1. In the acute setting, cardiac MRI will be performed in patients before and after a tonic-clonic seizure and compared intraindividually. In this study arm, potential acute seizure-induced myocardial damage will be detected. 2. In the chronic setting, … |
JULIAN ALEXANDER LUETKENS; | 2021-03-07 |
| 466 | Localization of The Reward Positivity to ACC PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The exact function of the anterior cingulate cortex (ACC) is one of the largest riddles in cognitive neuroscience and a major challenge in mental health research. ACC dysfunction contributes to a broad spectrum of neurological and psychiatric disorders, such as depression, ADHD, Parkinson’s disease, OCD and many others, but nobody knows what it actually does. Recently a new theory has been developed about ACC function; the HRL-ACC (Hierarchical Reinforcement Learning Theory of ACC). This theory proposes that the ACC selects and motivates high-level tasks based on the principles of hierarchical reinforcement learning. The ACC associates values with tasks, … |
ALFRED MEURS; | 2021-03-04 |
| 467 | Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Upon successful completion of this study, the investigators expect the study’s contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions. |
KATHRYN A DAVIS; | 2021-03-01 |
| 468 | Randomized Clinical Trial Comparing Efficacy of Optimal Treatment and Conventional Treatment for Major Depressive Disorder in Viet Nam PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparison of efficacy treatment (respond, remission) between the optimized treatment group (dose adjustment or early change other drug based on the change of total score HAM-D 17) and the routine treatment group (start with the lowest effective dose and adjust dose slowly) for depressed patients in Viet Nam |
LE NGUYEN THUY PHUONG; | 2021-03-01 |
| 469 | ‘MindRest: Mindful Network Dynamics Regulation Under Stress PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the effectiveness of Mindfulness Based Stress reduction to reduce perceived stress in a highly stressed student population, while concurrently investigating neural mechanisms of the intervention. The investigators will perform a randomized, wait-list controlled trial assessing clinical and neurocognitive outcomes as well as measures of daily life stress reactivity. |
ERNO HERMANS; | 2021-03-01 |
| 470 | Cannabidiol for Fibromyalgia -The CANNFIB Trial Protocol for A Randomized, Double-blind, Placebo-controlled, Parallel-group, Single-center Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Fibromyalgia is serious chronic pain condition which is often accompanied by sleep disturbances, fatigue and disability and reduced quality of life. There is no cure and treatments are based on reliving symptoms and maintaining function. The currently available medical treatments are not helping many patients, and many get side-effects. Medical cannabis is sought after among patients and many use this medication un-licenced, although it is not properly documented if it works or is safe. Therefore, … |
MARIUS HENRIKSEN; | 2021-03-01 |
| 471 | Development of A Room Temperature Atomic Magnetrode System for Telemetry of Epileptic Seizures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to help scientists learn about the use of a device called an atomic magnetometer. The device uses sensors called optically-pumped magnetometers (OPM) which function at room temperature. This research will compare the non-invasive brain imaging application of the OPM sensors to the present SQUID-based cryogenic sensor technique used in conventional Magnetoencephalography (MEG). This study is being conducted in conjunction with the University of Colorado Boulder’s Mechanical Engineering Department. |
ISABELLE BUARD; | 2021-03-01 |
| 472 | SeizURe Frequency During A Radiotherapy COurse for High-Grade Gliomas PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this trial is to evaluate the seizure frequency during a course of radiotherapy for high-grade (grade III or IV) gliomas. The patients keep a seizure diary during and up to 6 weeks following radiotherapy. Every day, the patients document the number (and type) of seizures and intake of anti-epileptic medication. At the end of radiotherapy, the patients are asked to complete a questionnaire regarding their satisfaction with the seizure diary. Progression of seizure activity compared to baseline is defined as increase of frequency of seizures by more than 50%, increase of severity of seizures, … |
DIRK RADES; | 2021-03-01 |
| 473 | Glycerol Phenylbutyrate for STXBP1 Encephalopathy (STXBP1-E) and SLC6A1 Neurodevelopmental Disorder (SLC6A1-NDD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: STXBP1 Encephalopathy is a severe disease that can cause seizures and developmental delays in infants and children. It occurs when one copy of the STXBP1 gene has a mutation that causes the gene’s protein to not work properly. SLC6A1 neurodevelopmental disorder is characterized by developmental delay and often epilepsy. It occurs when one copy of the SLC6A1 gene has a mutation that causes the gene’s protein to not work properly. Both STXBP1 encephalopathy and SLC6A1 neurodevelopmental disorder cause symptom because there are not enough working proteins made by these genes. It is possible that a medication called phenylbutyrate may help the the remaining proteins work better. This study is to test if phenylbutyrate is safe and well tolerated in children with STXBP1 encephalopathy and SLC6A1 neurodevelopmental disorder. |
ZACHARY GRINSPAN; | 2021-03-01 |
| 474 | Study of The Association Between Burst Suppression During Anesthetic Induction With Propofol in Cardiac Surgery in Patients Over 65 Years of Age With Postoperative Delirium PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The population over 65 years of age will be increasingly exposed to surgical procedures that require general anesthesia. Postoperative delirium is one of the main causes of preventable postoperative morbidity in the elderly population and is a frequent event after cardiac surgery with extracorporeal circulation. The excess administration of anesthetics that potentiate the Gamma Aminobutyric A receptor, such as propofol, … |
JUAN C PEDEMONTE; | 2021-03-01 |
| 475 | Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Some patients with chronic subdural hematomas and transient neurological symptoms do not respond to standard antiepileptic drugs. The investigators think that some of them could have cortical depression rather than epileptic discharges. After an intensive literature review, the investigators found out that some antiepileptic dugs (Lamotrigine, Topiramate) were found to be efficient to treat cortical depression in other conditions (migraine, subarachnoid hemorrhage). In contrast, some other drugs (Levetiracetam) were not proved to be efficient. Knowing that, the investigators want to compare the efficacy of Topiramate against Levetiracetam in two different groups, … |
CHRISTIAN IORIO-MORIN; | 2021-03-01 |
| 476 | Multimodal Profiling of People With Epilepsy to Determine Which Signals Are Clinically Useful for Long-term Home Monitoring PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators plan to determine whether it is possible to use a small, unobtrusive wearable device (the Sensor Dot with Plug ‘n Patch system) to follow-up epilepsy in the home environment through measurement of different biosignals (EEG, ECG, EMG, motion, skin temperature, respiration and oxygen saturation) for prolonged periods in patients with epilepsy. If this is possible, the investigators will study the chronobiology of epilepsy. |
WIM VAN PAESSCHEN; | 2021-03-01 |
| 477 | A Pregnancy Registry to Assess The Safety of Antimalarial Use in Pregnancy PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The MiMBa (Malaria in Mothers and Babies) Pregnancy Registry aims to generate robust evidence on the safety of a range of antimalarials when used in pregnancy, particularly in the first trimester. This will be a multi-country observational study and will be deployed in several field sites in Africa. |
LIVERPOOL SCHOOL OF TROPICAL MEDICINE | 2021-02-22 |
| 478 | Efficacy of New Lenses in Abolishing Photoparoxysmal Responses in Paediatric Patients With Photosensitive Epilepsy (PSE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background. Blue lenses that filter out red light have been proposed as a new therapeutic alternative for patients with PSE, such as the lens Zeiss Clarlet Z1. This lens only allows a small overall quantity of visible light, and particularly a minimum percentage of red light, to pass through. However, these characteristics entail two main pitfalls: reduced applicability in high- latitude regions and lack of transmission for the red and yellow colors. The latter would mainly expose patients to the other colors that compose the visible light, … |
ANA CHECA-ROS; | 2021-02-20 |
| 479 | The Effect of Fine Motor Grip Studies in Virtual Reality Environment on Performance-Based Hand Skills in Children With Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral Palsy (CP) is a neurodevelopmental dysfunction which is permanent, non-progressive, and caused by brain insult or injury.Although the basic finding of CP is having motor function problems, visual, auditory, cognitive and behavioural problems are also seen in CP.Having these problems interfere the functional independence of children with CP, so their daily life of activities is limited.One of the way of increasing the functional independence of these children is providing them hand rehabilitation.In the event of having hand rehabilitation, children would achieve more daily living skills.Although having hand rehabilitation is crucial for these children, … |
AYŞE NERIMAN NARİN; | 2021-02-16 |
| 480 | Advanced EEG Technology in Childhood Epilepsy: A Multimodal Wearable Approach for Long-term Seizure Detection and Sleep Monitoring PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A lot of effort has already been put into the development of smaller, wearable and more user-friendly devices to monitor seizures in patients with epilepsy. The investigators hypothesize that a wearable EEG ( in combination with additional non-EEG biosignals (motion, ECG, EMG, respiration, temperature,…) derived from Byteflies Sensor Dot and new medical patches (Plug ‘n Patch system), … |
UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN | 2021-02-01 |
| 481 | The Effect of Parent-based Occupational Therapy on Parents of Children With Cerebral Palsy: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background/Aims Parents of children with cerebral palsy face higher levels of stress, anxiety and depression, sadness, exhaustion and burnout. Parent-based therapies have been found to increase parents’ satisfaction with therapy, parent-child interactions and reduced parental stress. This study examined the effects of parent-based occupational therapy on stress levels, coping skills, and emotional skills and competencies of parents of children with cerebral palsy. Methods A total of 15 children and their parents who were admitted to the paediatric rehabilitation unit for occupational therapy were divided into two groups (control group: n=7, … |
GOKCEN AKYUREK; | 2021-02-01 |
| 482 | Investigation of Activity and Participation Levels in Children With Down Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the activity participation levels of Down syndrome(DS) children and the restrictive or supportive factors affecting their participation levels and to investigate their effects on quality of life. 35 children diagnosed with DS by a pediatric neurologist and 35 typically developing children are planned to be included in this study. Sociodemographic data of typically developing and DS children who agreed to participate in the study and their families will be questioned. Activity (Gross Motor Function Measurement-GMFM-88) , … |
DUYGU TURKER; | 2021-02-01 |
| 483 | An Initial Clinical Study to Treat Postictal Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy. One group will receive ibuprofen, another will receive nifedipine, and anther placebo. |
PAOLO FEDERICO; | 2021-02-01 |
| 484 | Consequences of Co-Administration of Propofol With Clonidine and Ketamine Throughout Colon Cancer Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Study Showed that combining clonidine and ketamine together can increase the likelihood of achieving a sufficient level of anaesthesia while minimizing post-operative discomfort and inflammation. |
NIRVANA ELSHALAKANY; | 2021-02-01 |
| 485 | A Multi-center,Open-label Real-world Study to Evaluate The Efficacy and Pharmaco-economics of Lacosamide As First Add-on Therapy for Adults and Children With Focal Onset Seizures PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to evaluate the efficacy, safety, and pharmaco-economics of Lacosamide Tablet as first add-on therapy for uncontrolled focal onset epilepsy ,invetigating effects of lacosamide Tablet on cognitive function of children and anxiety and depression of adults with focal onset seizures In real-world clinical setting |
DONG ZHOU; | 2021-01-31 |
| 486 | ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We propose to study approach/avoidance behavior as measured by the Approach Avoidance task in 20 epilepsy patients undergoing implementation of depth electrodes for seizure monitoring in the Epilepsy Monitoring Unit at MGH. We will also study the effects of VC/VS electrical stimulation on approach-avoidance conflict in 20 adult patients who have undergone DBS implantation for severe MDD and/or OCD. There are 100-200 patients in the world with DBS electrodes in the VC/VS, … |
DARIN DOUGHERTY; | 2021-01-23 |
| 487 | The Development of An Algorithm to Detect Sleep Structure With A Wearable EEG Monitor in An Elderly Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate whether it is able to perform sleep staging with EEG data recorded from 2 electrodes behind each ear. |
UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN | 2021-01-21 |
| 488 | Association Between GPX4 Dependent Ferroptosis Pathway and Epilepsy in School-aged Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is one of the most common neurologic disorders seen in children, often characterized by recurring seizures. Nearly 10.5 million children worldwide are estimated to have active epilepsy. Children with epilepsy are more likely to have developmental health and developmental comorbidities such as depression, anxiety, attention deficit hyperactivity disorder, learning disabilities, … |
AFFILIATED HOSPITAL OF JIANGNAN UNIVERSITY | 2021-01-20 |
| 489 | Pulvinar Stimulation in Epilepsy: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Deep brain stimulation (DBS) is one of the neuromodulation techniques that can be indicated in patients suffering from refractory epilepsies, especially when an open resection has failed or is not indicated, and vagal nerve stimulation (VNS) demonstrated no efficacy. Benefits such as reduction of seizure frequency have been shown for thalamic stimulation of the anterior thalamic nucleus (ANT), however it has limited efficacy and non-optimal neurocognitive outcome, … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2021-01-15 |
| 490 | Galactose Supplementation for The Treatment of Patients With Mild Malformation of Cortical Development With Oligodendroglial Hyperplasia in Epilepsy (MOGHE): A Pilot Trial Related Papers Related Patents Related Grants Related Experts View Highlight: Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a new entity frequently associated with refractory epilepsy and neurodevelopmental disorders. Recently, it has been associated to SLC35A2 (Solute Carrier Family 35 Member A2) brain mosaic pathogenic variants. In addition, patients with germline SLC35A2 pathogenic variants improve with galactose supplementation. Therefore, the investigators aim to elucidate whether d-galactose as an add-on treatment might improve epilepsy and developmental outcomes in patients with MOGHE. |
ANGEL ALEDO-SERRANO; | 2021-01-15 |
| 491 | Mindfulness Meditation for Epilepsy: Effect of Mindfulness Meditation Practice on Quality of Life and EEG Activity in Refractory Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In one-third of epileptic patients treated in France, seizures persist despite drug treatment. These so-called refractory epilepsies are among the most severe. Only a minority of patients with refractory epilepsy can undergo surgery. The other options available are based on brain or vagus nerve stimulation interventions which clinical effectiveness is still being studied. Alternative therapies are needed both to decrease the frequency of patients’ seizures and to improve their quality of life. The practice of mindfulness meditation has recently been included in the recommendations of the International League Against Epilepsy in order to alleviate anxiety or depression comorbid symptoms. This study falls within this framework by targeting two aspects of the pathology. |
ANCA NICA; | 2021-01-14 |
| 492 | SLC13A5 Deficiency: A Prospective Natural History Study – Remote Only (International) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: SLC13A5 deficiency (Citrate Transporter Disorder, EIEE 25) is a rare genetic disorder with neurodevelopmental delays and seizure onset in the first few days of life. This natural history study is designed to address the lack of understanding of disease progression and genotype-phenotype correlation. Additionally it will help in identifying clinical endpoints for use in future clinical trials. |
BRENDA E PORTER; | 2021-01-04 |
| 493 | A Real-world Clinical Study to Evaluate The Effectiveness and Safety of Perampanel As An Add-on Treatment for Epileptic Seizure PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a real-word clinical trial. The purpose of this study is to evaluate the effectiveness and safety of perampanel as an add-on treatment for epileptic seizure. The enrolled subjects were epilepsy patients who had failed clinical treatment with 1-3 anti-epileptic drugs (AEDs) with the optimal dose and course of treatment and needed additional treatment. The study was a real-world prospective clinical study, and the initial and maximum doses of perampanel were individualized by neurologists according to the patient’s clinical situation. |
XIAODAN LI; | 2021-01-01 |
| 494 | Evaluation of The Effect of Chloral Hydrate, Hydroxyzine and Melatonin Used As Sedative Drugs in EEG Recording in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Electroencephalogram (EEG) has an important place in establishing the correct diagnosis, providing appropriate intervention, and predicting the prognosis in the long term in children. When the literature is examined, it is seen that different sedative drugs (benzodiazepines, barbiturates, phenothiazine, chloral hydrate, hydroxyzine, melatonin, etc.) and their combinations are used to provide sedation during EEG recordings, but there is no ideal sedative drug. Nurses working in the field of pediatric neurology in EEG recordings; It has important roles in preparing the child and parent for the procedure, applying sedation before the procedure, performing the EEG recording properly, … |
SERIFE TUTAR; | 2021-01-01 |
| 495 | Sleep Problems in Epileptic Children and Their Caregivers: Associations With Psychometric PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the frequency of sleep problems in epileptic children and their caregivers. |
İPEK DOKUREL; | 2021-01-01 |
| 496 | The Predictive Role of Seizures and Anitiepileptic Therapy on Rehabilitation Course of Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: post-traumatic seizures (PTS) are a common and debilitating complication of traumatic brain injury (TBI) and could have harmful impact on patient disabilty and rehabilitation outcome. In this multicentric prospective observational study we aimed to evaluate the role on functional outcome of patients admitted to neurorehabilitation unit afther traumatic brain injury of: – newly occurring seizures – prescription of antiepileptic prophylactic therapy The inclusion criteria were the following: 1) age ≥ 18; 2) diagnosis of TBI on presentation; 3) admission to a hospital emergency department within 24 h of injury; … |
ANTONIO NARDONE; | 2021-01-01 |
| 497 | Clinical Phenotype and Omics Study of KCNQ2-related Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aims of study on KCNQ2-related epilepsy: (1) establish phenotype database and sample database of KCNQ2-related epilepsy; (2) to establish genotype-phenotype association of KCNQ2-related epilepsy; (3) to study the brain network of KCNQ2-related epilepsy based on multi-modal brain image and EEG data; (4) to find prognostic biomarkers of KCNQ2-related epilepsy based on omics study. |
YI WANG; | 2021-01-01 |
| 498 | Microendoscopic Transventricular Deep Brain Stimulation of The Anterior Nucleus of The Thalamus As A Safe and Efficient Treatment in Intractable Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Deep Brain Stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has been proposed in patients with severe intractable epilepsy. When used, the transventricular approach increases the risk of bleeding due the anatomy around the entry point in the thalamus. To avoid such a complication, the investigators used a transventricular microendoscopic technique. |
GAËTAN POULEN; | 2021-01-01 |
| 499 | Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression Related Papers Related Patents Related Grants Related Experts View Highlight: Major depressive disorder (MDD) is common and causes significant disability world-wide. While typically responsive to medications and therapy, there remain a subset of patients who are treatment resistant. Novel approaches are critical to treat these patients. MDD is likely caused by dysfunction in distributed neural networks, a perspective consistent with the etiological and diagnostic heterogeneity of this disorder. While imaging and electroencephalography (EEG) have helped identify MDD circuitry, no consensus has been reached on the identification of diagnostic biomarkers. Furthermore, … |
ANDREW KRYSTAL; | 2021-01-01 |
| 500 | E-MhGAP Intervention Guide in Low- and Middle-income Countries: Proof-of-concept for Impact and Acceptability PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Two strategies will be compared for training and supervising primary care workers delivering mental health services. Both strategies will use the World Health Organization mental health Gap Action Program-Intervention Guide. In the standard strategy, … |
BRANDON A KOHRT; | 2020-12-27 |