Clinical Digest: Recent Clinical Trials on Heart Disease
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Heart Disease. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Heart Disease
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Evaluation of A POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The EPOCA study (Evaluation of a POlypill and Colchicine for risk reduction in patients with established Atherosclerotic cardiovascular disease) will be a randomized, superiority, parallel, 2×2 factorial, multicenter clinical trial which will include at least 7713 and up to a maximum of 10797 participants with established atherosclerotic cardiovascular disease. |
LUCAS TRAMUJAS; | 2025-05-01 |
| 2 | Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study, entitled Psychological trauma, post-traumatic stress disorder, and resilience in adults with congenital heart disease in a large population sample, is to evaluate for exposures during a lifetime with congenital heart disease that may be associated with higher likelihood of developing PTSD. Primary aim: – Identify individual patient characteristics (medical, psychosocial, socioeconomic, etc.) that are associated with a diagnosis of PTSD. Secondary aims: * Calculate the prevalence of those meeting PTSD criteria in the ACHD population using the gold standard diagnostic clinician interview, … |
DAVID J. HARRISON; | 2025-05-01 |
| 3 | Pregnancy Outcomes in Patients With Adult Congenital Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if a biomarker assay obtained peripartum (1st-3rd trimester and post-partum) in patients with adult congenital heart disease can predict future risk of cardiovascular adverse events and determine if temporal changes in biomarkers levels throughout the peripartum period can provide a better risk prediction compared to samples taken at a single time-point. |
ALEXANDER C. EGBE; | 2025-05-01 |
| 4 | Feasibility and Pilot Testing of The My Heart and CKD Online Shared Decision Aid PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Many people with kidney disease also have heart disease. The procedures used to diagnose and treat heart disease (e.g., angiograms, angioplasty, or surgery) can improve symptoms and cardiovascular outcomes, … |
MATTHEW T JAMES; | 2025-05-01 |
| 5 | RestoratIon of Myocardial Function By PeRcutaneous COronary InterVEntion in Patients With Ischemic CardioMyoPathy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the effects of physiology- and imaging-guided PCI combined with optimal medical therapy (OMT) versus OMT alone on the recovery of left ventricular systolic function in patients with ischemic cardiomyopathy and multivessel coronary artery disease. |
SEOUL NATIONAL UNIVERSITY HOSPITAL | 2025-05-01 |
| 6 | Prenatal Maternal Mental Health and Neurodevelopment in Children With An Antenatal Diagnosis of Congenital Heart Disease: The Neuro-Moms CHD Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart disease (CHD) is the leading cause of congenital malformations, representing 1% of live births. Progress in surgical care have led to the dramatic increase in the population of children and adults living with heart disease. As survival is no longer a concern, long-term outcomes have become the major public health issue. Prenatal diagnosis of CHD requiring open-heart surgery can be a traumatic event for expecting mothers and fathers. In the general population, maternal mental health distress is associated with fetal disturbances in the hypothalamic-adrenal-pituitary system axis, … |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE FRANCE | 2025-05-01 |
| 7 | Cardiovascular Effects of SGLT2 Inhibitors in Hemodialysis Patients: A Phase 2 Randomized Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with end-stage kidney disease (ESKD) on hemodialysis face an unacceptably high rate of cardiovascular complications, including heart failure, arrhythmias, and sudden cardiac death. Many of these outcomes are driven by diastolic dysfunction and cardiac fibrosis-conditions that are not adequately addressed by current therapies. SGLT2 inhibitors, originally developed for the treatment of type 2 diabetes, have demonstrated cardiovascular and renal protective effects across multiple patient populations, independent of glycemic control. This Phase 2, randomized, … |
MAXIMO AGUSTIN SCHIAVONE; | 2025-05-01 |
| 8 | Effects of Age, Sex and Isometric Exercise on Ventricular-Vascular Interactions During Cardiac Unloading PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As people get older, especially women, they often feel dizzy or even faint when they go from sitting or lying down to standing up. This happens because their blood pressure (BP) drops, which can lead to falls, heart problems, and even death in older adults. When BP changes, it affects how well the heart works and how it talks with blood vessels. However, little research has been done on how the heart and blood vessels talk during times of low BP. The crosstalk between the heart and blood vessels is important, … |
TRACY BAYNARD; | 2025-05-01 |
| 9 | Redefining BMI: The Body, Mind, and Inflammation Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Emerging adulthood (18-25 years of age) is a critical developmental window to promote weight management and cardiometabolic health, particularly for emerging adult women. The primary purpose of this study is to test the preliminary efficacy of the intensive lifestyle intervention for EA women in reducing adiposity, as well as improving biomarkers of inflammation and metabolic risk over 12 months compared with a traditional behavioral weight loss intervention. This treatment program will be tested in emerging adult (EA) women ages 18-25 years old with a BMI of 25-50 kg/m\^2. |
JESSICA LAROSE; | 2025-05-01 |
| 10 | Inorganic Nitrate As A Treatment for ANOCA: NO-ANOCA Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to see if inorganic nitrate in the form of beetroot juice helps blood flow and physical fitness in women with ANOCA and CMD. The main questions it aims to answer are: AIM 1: Test the hypothesis that fourteen days of nitrate rich beetroot juice will increase cardiac perfusion and improve quality of life compared to placebo. AIM 2: Test the hypothesis that fourteen days of nitrate rich beetroot juice will increase physical fitness and reduce angina and dyspnea symptoms compared to placebo. Exploratory AIM 3: Test the hypothesis that fourteen days of nitrate rich beetroot juice will improve vascular health and function. Participants will: * Take study beverage for 4 weeks total. * Stress Cardiac magnetic resonance imaging and 12 lead electrocardiograms * Complete questionnaires * Cycling exercise test * Non invasive vascular testing * Blood draws |
PATRICIA RODRIGUEZ LOZANO; | 2025-05-01 |
| 11 | Effectiveness of Inclisiran for Patients With Coronary Heart Disease in China: A Multicenter, Standard of Care-Controlled Pragmatic Randomized Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The current study will be conducted to evaluate the real-world effectiveness of inclisiran relative to standard of care (SoC) in Chinese patients with coronary heart disease (CHD), not only with the low-density lipoprotein cholesterol (LDL-C) change in 1 year, but also the LDL-C Test on Target for 1 year. This study further aims to assess the adherence, treatment patterns and satisfaction, and safety of inclisiran among Chinese patients. |
NOVARTIS PHARMACEUTICALS | 2025-04-30 |
| 12 | The Impact of Cognitive Behavioral Intervention On Postoperative Delirium In School-aged Children With Sleep Disorder Undergoing Congenital Heart Surgery: A Multicenter, Randomized Controlled Clinical Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered school-aged children undergoing congenital heart surgery. The study will include infants and toddlers undergoing elective cardiac surgery with sleep disorders, assessed by the Children’s Sleep Habits Questionnaire (CSHQ). All participants will be randomly assigned to the intervention group and Controll group in a 1:1 ratio. The intervention group received a short intensive cognitive-behavioral intervention 7-14 days before surgery, … |
YAN FUXIA; | 2025-04-28 |
| 13 | Comparison of Transcatheter Aortic Valve Replacement With Surgical Aortic Valve Replacecment: A Prospective, Multicenter, International, Randomized Controlled, Non-inferiority Study for Bicuspid Aortic Valve Stenosis (PROMIS-BAV) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and effectiveness of the Transcatheter aortic valve and retrievable delivery system (VitaFlow Liberty®) for the treatment of severe bicuspid aortic valve (BAV) stenosis. |
MAO CHEN; | 2025-04-21 |
| 14 | Improving Cardiovascular Health in Veterans With PTSD By Treating Trauma-Related Nightmares With NightWare PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD). The investigators also want to learn whether it improves cardiovascular health among this population. |
KERRIE L MOREAU; | 2025-04-21 |
| 15 | Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery: Prospective, Randomized, Double-blinded, Placebo-controlled, Multi-centre Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery. However, research in recent years has yielded limited preventive and therapeutic measures for myocardial injury/MACE. Recent studies in patients with chronic and acute coronary artery disease have shown that colchicine administration can reduce the risk of cardiovascular events. These encouraging results in non-surgical patients ask for a similar investigation in patients undergoing major non-cardiac surgery. The aim of the proposed study is to investigate the effects of perioperative colchicine administration on the incidence of myocardial injury/MACE. |
TIMUR YURTTAS; | 2025-04-20 |
| 16 | Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the control effect of smart wearable devices on key risk factors in the high-risk populations for stroke |
AFFILIATED HOSPITAL OF NANTONG UNIVERSITY | 2025-04-20 |
| 17 | Exploring Precision Medicine in The CICU: Feasibility of Proteomic Biomarkers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital Heart disease (CHD) is a leading cause of childhood death. Substantial morbidity and mortality relates to the postoperative course. For example, only 70% of neonates survive to hospital discharge after their first complex surgery for single ventricle heart disease. Adverse systemic inflammatory responses are highly exaggerated in some children postoperatively. This inflammation is pathological, results in leaky blood vessels and fluid overload, toxin release as well as cell damage contributing to lung, … |
KATIE MOYNIHAN; | 2025-04-15 |
| 18 | Optimised Decrement Evoked Potential (DeEP) Mapping to Guide Ventricular Tachycardia (VT) Ablation in Patients With Structural Heart Disease VT PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder. Special pacemakers called implantable cardiac defibrillators (ICDs) help treat VT episodes, however they do not prevent the VT episodes from occurring. Catheter ablation for VT is a minimally-invasive and established procedure for preventing VT recurrence. This involves placing wires in the heart to find the diseased areas that are responsible for the VT episodes. The diseased areas are shown on computer-generated maps and are later removed via controlled tissue heating (ablation). A major challenge during the VT ablation procedure is locating the diseased area responsible for the VT episodes. Several methods have been described to locate the diseased heart area, however these methods are not always effective. In this study, we aim to improve the identification of the diseased heart areas responsible for the VT episodes using a novel method. Our research group have developed, tested and peer-reviewed this improved method of locating diseased areas by looking for signals called decrementing evoked potentials (DeEPs). Ablation will target DeEPs shown on the computer-generated maps. We will assess if VT can be triggered at the end of the procedure. Patients will be monitored over 12 months to see if ablation of DeEPs leads to a reduction in VT episodes. We aim to recruit 77 patients with established heart disease of any cause, who have suffered VT episodes with ICDs. Suitable patients will be identified and recruited from inpatient and outpatient settings. A quality-of-life questionnaire will be completed by patients before and after the ablation procedure. The procedure will be performed as routine standard of care, in the cardiac catheter laboratory across multiple recruiting cardiac centres in the UK providing well established VT ablation service. Overall, this study will contribute towards developing refined VT ablation techniques, aiming to improve patient outcomes. |
UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST | 2025-04-11 |
| 19 | Tulane IPredict, Prevent (TiPP) Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the progression of atrial myopathy through wearable devices and cardiac imaging. |
NASSIR F MARROUCHE; | 2025-04-08 |
| 20 | The Pragmatic EE-PRS Trial Assessing Polygenic Risk Driven Statin Therapy for Cardiovascular Disease Prevention PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This research investigates the potential advantages of intensive preventive statin treatment for healthy men aged 45-80 and women aged 55-80 who possess a high genetic predisposition to coronary artery disease (CAD). By specifically targeting the top 20% of individuals with elevated CAD polygenic risk scores (PRS), the study seeks to find out whether this tailored approach can notably decrease the occurrence of cardiovascular disease and mortality over a five-year period when compared with usual care. Despite the potential of PRS in pinpointing individuals at heightened risk for cardiovascular disease, … |
MIKK JÜRISSON; | 2025-04-01 |
| 21 | Discontinuation of Antiplatelet Agent After Drug-Coated Balloon Angioplasty in Stabilized Patients With High Bleeding Risk and Coronary Artery Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, multi-center, open-label, randomized controlled, and superiority trial. The trial will compare clinical outcomes between discontinuation of antiplatelet agent and continuation of antiplatelet agent in HBR patients with chronic coronary syndrome treated by DCB angioplasty and standard duration of DAPT, followed by maintenance of single antiplatelet agent without clinical event for at least 1 year from the index procedure. |
JOO MYUNG LEE; | 2025-04-01 |
| 22 | Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study design is a prospective registry including asymptomatic and symptomatic patients who carry a pathogenic TTR mutation. The study will enroll patients who meet the inclusion criteria and none of the exclusion criteria until 1000 patients are enrolled, at which point in time the study investigators will evaluate whether further patient accrual is meaningful. |
KEYUR SHAH; | 2025-04-01 |
| 23 | Clinical Features, Current Treatment and Clinical Outcomes in Patients with Inflammation-associated Non-rapidly-progressive Coronary Artery Disease (INR-CAD): A Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a cohort study to investigate the clinical features, current treatment and clinical outcomes in patients with inflammation-associated non-rapidly-progressive coronary artery disease (INR-CAD). |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2025-04-01 |
| 24 | Treatment of Moderate Ischemic Mitral Regurgitation in Patients With Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effect of angiotensin receptor/neprilysin inhibitors (ARNI) on improving ischemic mitral regurgitation (IMR) in patients with coronary artery disease undergoing isolated coronary artery bypass grafting (CABG) through a randomized controlled clincial trial. |
CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES | 2025-04-01 |
| 25 | Sedation of Remazolam in Combination With Afentanil in Non-intubated Thoracoscopic Pulmonary Surgery: A Single-blind, Randomized, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-intubated Thoracoscopic surgery (NITS) is a newly emerging minimally invasive surgical technique in recent years . Compared with traditional intubation general anesthesia, it has the advantages of less trauma, faster recovery and fewer complications . This surgical method allows patients to perform under local anesthesia or regional block and moderate sedation, providing a physiologic ventilation method , reducing the intervention on the respiratory system and conducive to rapid postoperative recovery. The importance of sedative drugs in non-intubated thoracoscopic surgery Successful implementation of non-intubated thoracoscopic surgery requires sound regional block, airway management, … |
JIANBO WU; | 2025-04-01 |
| 26 | Innovative Therapy to Treat Women with Angina with Nonobstructive Coronary Artery Disease (ANOCA) and Coronary Microvascular Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to that Sodium-glucose cotransporter 2 inhibitors treatment will improve Coronary Microvascular Disease with anginal symptoms associated with non-obstructive coronary disease in women. The main questions it aims to answer are: Aim 1: Test the hypothesis that Sodium-glucose cotransporter 2 inhibitors treatment improves coronary microvascular disease in women with no evidence of epicardial obstructive coronary artery disease. Aim 2: Test the hypothesis that Sodium-glucose cotransporter 2 inhibitors treatment improves angina symptoms and other quality of life measurements associated with the improvement of CFR. AIM 3: Identify the effect of Sodium-glucose cotransporter 2 inhibition on inflammation pathways and markers of systemic Research will compare Dapagliflozin to placebo Participants will: * Take study drug or placebo for 12 weeks * Stress Cardiac magnetic resonance imaging * 12 lead electrocardiograms * Complete questionnaires |
PATRICIA RODRIGUEZ LOZANO; | 2025-04-01 |
| 27 | Atrioventricular (AV) Node Ablation and Conduction System Pacing in Patients with Well Controlled Permanent Atrial Fibrillation (AF), Heart Failure and Preserved Ejection Fraction: Heart Rate Regularization Vs. Medical Rate Control PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the clinical efficacy of physiological pacing combined with atrioventricular node ablation, in patients with Heart Failure with preserved Ejection Fraction (HFpEF) and well controlled permanent atrial fibrillation.The main question it aims to answer is that heart rate regularization added to physiological pacing – preventing the deleterious effect of right ventricular apical pacing – … |
FRÉDÉRIC ANSELME; | 2025-04-01 |
| 28 | Dietary Fish Oil and Metformin Intervention for Heart Health in PCOS PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes. |
UNIVERSITY OF ALBERTA | 2025-04-01 |
| 29 | Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure (HF) is a severe cardiovascular disease with extremely high morbidity and mortality rates worldwide, and ischemic cardiomyopathy is an important cause of heart failure. Vericiguat is a soluble guanylate cyclase stimulator which has been verified to improve the cardiovascular outcomes in heart failure patients. The VICTORIA trial excluded patients with acute coronary syndrome in 3 months prior to the study start, so it is still unclear about the efficacy and safety of vericiguat in heart failure after acute myocardial infarction. So we conducted this multi-center, prospective, … |
DONGYING ZHANG; | 2025-04-01 |
| 30 | Antenatal Investigation of Fetuses With Complex Congenital Heart Defects Using MultiOMICS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will use multiOMICS study on fetuses with complexe congenital heart defects (CHD) to identify etiological epigenetic factors of these cardiac malformations, related to environmental factors during pregnancy. |
CAROLINE ROORYCK-THAMBO; | 2025-04-01 |
| 31 | Assessment of Atrial Cardiomyopathy Using MRI As A Predictor of Cardiac Post-Operative Atrial Fibrillation After Cardiac Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After cardiac surgery, there is a high prevalence of postoperative atrial fibrillation (POAF). However, its diagnostic and therapeutic management is poorly codified. This pathology is caused by atrial abnormalities which form the concept of atrial cardiomyopathy. New tools affording to itemize the atrial cardiomyopathy are needed. Indeed, current tools, as echocardiography and electrocardiogram are relevant but only lead to a raw evaluation of the atrial cardiomyopathy. MRI, because of the assessment of the atrial fibrosis by late gadolinium assessment (LGE) and 4D flow magnetic resonance imaging (MRI) could be relevant to specify the atrial cardiomyopathy. |
JEAN-BAPTISTE GUICHARD; | 2025-04-01 |
| 32 | Short-term Exposure to High Altitude in Patients With Asymptomatic Aortic Stenosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aortic stenosis is a common disease with increasing prevalence due to an aging population. Aortic valve replacement is indicated for symptomatic severe aortic stenosis. Leisure activities and tourism at high altitude destinations are popular but may impose a higher risk to patients with aortic stenosis. Pathophysiological considerations led to an expert consensus to avoid high altitude exposure, though there is no robust scientific evidence. Hence, … |
THOMAS PILGRIM; | 2025-04-01 |
| 33 | Postpartum Cardio-obstetric Rehabilitation After Hypertensive Pregnancy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Some women who develop high blood pressure during pregnancy, such as gestational hypertension or preeclampsia, may continue to have slightly or moderately high blood pressure after giving birth. This can increase their risk of heart disease later in life. Managing blood pressure and adopting a healthy lifestyle after pregnancy could help lower this risk. Right now, the investigators don’t know much about how postpartum rehabilitation programs focused on heart and pregnancy-related health could help women with these conditions. However, … |
MARIANE BERTAGNOLLI; | 2025-04-01 |
| 34 | The Brain-heart-gut Connection (BHG-CONNECT): Targeting The Frontal-vagal Pathway to Personalize Noninvasive Brain Stimulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Major Depressive Disorder (MDD) often co-occurs with cardiovascular and gastrointestinal symptoms, highlighting the importance of the brain-heart-gut connection in developing comprehensive treatments. Previous research suggests that key hubs in the depression network, such as the dorsolateral prefrontal cortex (DLPFC) and the subgenual anterior cingulate cortex (sgACC), overlap with structures that are involved in autonomic control, particularly the vagus nerve. Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC is an established treatment for MDD; however, antidepressant efficacy varies greatly across individuals, … |
JESSICA JACOBS; | 2025-04-01 |
| 35 | Phase 1 Feasibility and Safety of Whole Heart Radiotherapy for End-stage Heart Failure: First In-human Treatments Related Papers Related Patents Related Grants Related Experts View Highlight: End-stage heart failure (ESHF) causes recurrent hospitalizations, cardiac arrhythmias, and intolerance to standard HF therapies are common as the disease progresses. Management focuses on controlling symptoms, correcting precipitants, avoiding triggers, and improving quality-of-life. The combination of recent preclinical and clinical data suggests that localized cardiac RT is relatively safe and has positive conductive and anti-proliferative effects in the sick heart. In this Phase 1 study, … |
TAREK HIJAL; | 2025-04-01 |
| 36 | Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study has the purpose to answer how the Lipoprotein(a) (Lp(a)) level is distributed among Atherosclerotic cardiovascular disease (ASCVD) patients in Russia, and what is the connection between elevated levels of this parameter and the cardiovascular disease (CVD) risk. |
NOVARTIS PHARMACEUTICALS | 2025-03-31 |
| 37 | Effects of Home-based Respiratory Muscle Training By Telerehabilitation on Quality of Life, Cardiopulmonary Function, Physical Status and Psychological Status in Individuals with Ischemic Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the present study is to verify whether respiratory muscle training programme (IMT+EMT; included both inspriratory and expiratory muscles), applied by telerehabilitation, is an effective intervention (versus placebo and versus inspiratory muscle training in isolation (IMT)) in improving quality of life, cardiopulmonary function and physical and psychological state in people with ischemic heart disease. In addition, the aim is to determine whether respiratory muscle training (IMT or IMT+EMT) is effective in enhancing the results obtained by a conventional cardiac rehabilitation programme on the aforementioned variables. |
IBAI LÓPEZ DE URALDE VILLANUEVA; | 2025-03-31 |
| 38 | Heart Evaluation of Acute Ischemic Stroke with Reperfusion Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart Evaluation of Acute ischemic stroke with Reperfusion Therapy (HEART) is a single-center observational registry evaluating the heart of patients hospitalized for acute ischemic stroke with reperfusion therapy. This registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies. |
JIANQIANG NI; | 2025-03-31 |
| 39 | Sodium-Glucose Cotransporter 2 Inhibitors for Repaired Tetralogy of Fallot Patients for Enhancement of Cardio-Pulmonary Status Trial (STEPS Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Repaired Tetralogy of Fallot (rTOF) is the leading cause of congenital cyanotic heart disease worldwide, involving up to 7-10% of congenital heart disease. With advances in open-heart surgical repair techniques and medical therapies, there is a significant increase in patients with rTOF surviving till late adulthood. One sequalae that nearly all rTOF patients develop during their lifetime is significant pulmonary regurgitation. Pulmonary regurgitation causes progressive right ventricular dilatation and systolic dysfunction, which in turn impairs cardio-pulmonary function and overall survival. There is currently no pharmacological therapy proven to improve cardio-pulmonary function in rTOF patients. In a double-blind, placebo controlled, … |
WONG CHUN KA; | 2025-03-31 |
| 40 | The Effect of Cardiac Rehabilitation on Oxidative DNA Damage and Inflammation in Patients with Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study was to determine the levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), an indicator of oxidative stress, and to demonstrate oxidative DNA damage in cardiac rehabilitation treatment in patients with coronary artery disease. Additionally, proinflammatory cytokines TNFα, IL-1β, and IL-6 levels were measured to evaluate the significance of cardiac rehabilitation treatment in patients with coronary artery disease and to assess the correlation between cytokine levels and 8-OHdG levels. |
HASAN KARA; | 2025-03-31 |
| 41 | Redirecting Poor Sleep Drivers of Early Cardiovascular Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Sleep health is a critical component of cardiovascular well-being, and poor sleep has been linked with increased risk for all-cause mortality including cardiovascular disease (CVD). Moreover, many individuals within a population may have underlying, subclinical cardiovascular conditions, such as hypertension and arterial stiffness, and these may risk progressing to advanced CVD when coupled with inadequate sleep duration and quality. Given that Singapore ranks as the third most sleep-deprived city globally, understanding the relationship between sleep health and the prevalence and progression of CVD becomes increasingly important for population health. In addition, … |
MICHAEL W.L. CHEE; | 2025-03-24 |
| 42 | Dual Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Large vessel vasculitis is a disease that causes damage to blood vessels. This damage to blood vessels can increase the risk of patients with LVV developing cardiovascular disease, including heart attacks and strokes. A chemical produced in the body called endothelin may contribute to this increase in cardiovascular disease risk by causing the vessels to stiffen and blood pressure to increase. It has previously been shown that by blocking the effects of endothelin, … |
UNIVERSITY OF EDINBURGH | 2025-03-21 |
| 43 | Effects of Vitamin D3 and Yeast Beta-Glucan Supplementation on Cardiovascular Disease in Patients with Type 2 Diabetes: A Randomized Double-Blind Controlled Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, double-blind, placebo-controlled trial involving 8,000 individuals aged 40-79 with type 2 diabetes. The trial includes a 2-year intervention period followed by 3 years of follow-up. The primary objective is to investigate whether daily dietary supplementation with vitamin D3 (1600 IU) or yeast β-glucan (600 mg) reduces the risk of major cardiovascular diseases, including myocardial infarction, stroke, treated or hospitalized heart failure, and cardiovascular deaths. The secondary objectives include evaluating the effects of vitamin D3 or yeast β-glucan supplementation on all-cause mortality, microvascular disease, cognitive function, and other outcomes. |
AN PAN; | 2025-03-20 |
| 44 | A Healthy Nordic Diet to Reduce The Progression of Atherosclerosis in Individuals with Coronary Heart Disease: A Secondary Prevention Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear. The investigators will investigate if a healthy Nordic diet (HND) reduces plaque volume, coronary artery calcification (CAC), and plaque inflammation (FAI) in CHD, … |
ULF RISÉRUS; | 2025-03-20 |
| 45 | Vitamin K Supplementation to Improve Cognition of Patients With Coronary Heart Disease: A Randomized Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pilot study is to obtain a preliminary assessment of the effect of VK supplementation on cognitive performance and vascular function in adults with stable Coronary Heart Disease (CHD) |
GUYLAINE FERLAND; | 2025-03-17 |
| 46 | Coronary Angioplasty With Sirolimus Drug-coated Stent System to Treat Patients With Symptomatic Ischemic Coronary Heart Disease: A PMCF Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To collect post marketing surveillance data on consecutive patients with coronary heart disease intended to be or treated by the Eucalimus sirolimus eluting PTCA stent when used according to the Instructions for Use. Data will be collected in order to assess the long term safety and performance of the Eucalimus PTCA stent in routine clinical practice. |
JOSEP GOMEZ-LARA; | 2025-03-14 |
| 47 | Circadian Mechanisms of Glycemic Control and Cardiovascular Risk in Adults With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. The investigators propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance the understanding of mechanisms by which improving sleep regularity influences glycemic control and cardiovascular risk in T1D. |
PAMELA MARTYN-NEMETH; | 2025-03-13 |
| 48 | Youth-onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases. Rates of type 2 diabetes have tripled in children and young adults over the last 40 years. Vascular diseases are also increasing in young people. Objective: To learn more about factors, including type 2 diabetes, that may cause vascular disease in young people. Eligibility: People aged 12 to 25 years who (1) have type 2 diabetes; (2) are overweight but not diabetic; … |
STEPHANIE T CHUNG; | 2025-03-12 |
| 49 | Evaluation of Valvular Heart Disease: Multicenter Registry of Noninvasive Imaging Modalities By Cardiac CT PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The EVIDENTIA Registry is a multicenter study designed to evaluate valvular heart disease (VHD) using cardiac CT. It aims to assess cardiac valve anatomy, function, and myocardial characteristics through detailed CT analysis. 1. Assessing the accuracy of cardiac CT in evaluating cardiac structure, volume, function, and myocardium in VHD patients. 2. Comparing the severity, classification, and etiology (primary vs. functional) of VHD. 3. Monitoring serial changes in VHD severity via echocardiography. 4. Investigating the relationship between echocardiographic and CT-derived parameters. 5. Examining the correlation between imaging findings, VHD interventions, and patient prognosis. |
HIDEKI KOIKE; | 2025-03-12 |
| 50 | Randomized Trial of Coronary Artery Disease Assessment Strategies in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronary artery disease (CAD) and aortic stenosis frequently coincide. Before valve intervention, invasive coronary angiography is routinely performed to assess coronary status. As the impact of percutaneous revascularization on clinical outcomes beyond symptom improvement is subject to debate and treatment of aortic stenosis itself reduces ischemic burden and symptoms, the benefit/risk balance of routine invasive coronary angiography prior to transcatheter aortic valve implantation (TAVI) is unclear. The CAT Trial aims to compare a non-invasive risk management strategy to routine invasive coronary angiography for the assessment of coronary artery disease in patients with severe, … |
JONAS LANZ; | 2025-03-11 |
| 51 | Effect of Point-of-care Analysis of Ultrasensitive Troponin I on Length of Hospital Stay in Patients With Cardiac Chest Pain: A Randomized Study (POC Troponina) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study aims to compare two different methods for measuring high-sensitivity troponin I, a key biomarker used to diagnose heart attacks. The primary research question is: Does the use of the Atellica VTLi kit from Siemens for high-sensitivity troponin I (hs-cTnI) testing at the point of care (POC) significantly reduce the average time from admission to hospital discharge compared to the conventional laboratory methodology using the Alinity i kit from ABBOTT? Participant will: * Patients aged ≥ 18 years. * Patients arriving in the emergency room with symptoms suggestive of ACS, … |
LUDHMILA ABRAHÃO HAJJAR; | 2025-03-10 |
| 52 | Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: A Randomised, Placebo-controlled, Mechanistic Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA). The main questions it aims to answer are: * Do beta-blockers improve coronary blood flow in patients with ANOCA? * Do beta-blockers reduce coronary microvascular resistance in these patients? Researchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation. Participants will: * Receive a beta-blocker or a placebo * Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment. |
VZW CARDIOVASCULAR RESEARCH CENTER AALST | 2025-03-10 |
| 53 | Mitral Valve Lithotripsy Using The SMARTWAVE Balloon for Severe Mitral Annular or Valvular Calcification (SMART-MAC): First in Human Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mitral stenosis (MS) is a heavily symptomatic valvular heart disease. Common causes of MS included chronic rheumatic heart disease (CRHD) and mitral annular calcification (MAC). Current guideline recommends percutaneous balloon mitral valvuloplasty (PBMV) being the first line intervention for rheumatic MS with favorable anatomy. However, severely calcified mitral valve (i.e. those with Wilkins scores\>8) makes the mitral valve non-pliable and carries high risk of severe mitral regurgitation (MR) (4-19%) with conventional balloon valvuloplasty. MAC is an increasingly recognized disease associated with atherosclerotic risk factors, and a well-recognized valve morphology that responses poorly with PBMV. Besides, … |
SO CHAK YU KENT; | 2025-03-08 |
| 54 | Study on The Efficacy and Safety of Metformin Hydrochloride Dicarboxylate Sustained-release Tablets (Ⅲ) in Patients With Type 2 Diabetes Mellitus Complicated With Coronary Heart Disease: An Open, Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is1. Compare the differences in the changes of glycated hemoglobin after 24 weeks of treatment between the new metformin sustained-release tablets (Ⅲ) group and the metformin ordinary tablets group. 2. Compare the differences in the changes of fasting blood glucose, gastrointestinal adverse reactions of the drug and compliance after 24 weeks of treatment between the new metformin sustained-release tablets (Ⅲ) group and the metformin ordinary tablets group. |
KEFEI DOU; | 2025-03-04 |
| 55 | The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in The United States (SPINS2) Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, … |
RAYMOND Y. KWONG; | 2025-03-01 |
| 56 | An International Multicenter Study on Transcatheter Device Closure of Perimembranous Ventricular Septal Defects PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The international multicenter registry aims to gather real-world data on patient outcomes and assess the procedural success and performance of various device occluders used in the transcatheter treatment of pediatric and adult patients with perimembranous ventricular septal defects (PmVSD). |
RAYMOND N. HADDAD; | 2025-03-01 |
| 57 | The Influence of Probiotics on Metabolome and Heart Rate Variability in Heart Failure of Structure Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Poor body weight gain and failure to thrive is a very common condition in patients with congenital heart disease (CHD) with advanced HF and/or cyanosis, which are considered a predictor of morbidity and complicate the prognosis of CHD. Studies have been carried out an attempt to discover the mechanisms to improve the therapies and the prognosis of these patients. Some of these studies give the hypothesis that the gastrointestinal tract, more precisely the intestine, … |
CHANG GUNG MEMORIAL HOSPITAL | 2025-03-01 |
| 58 | PMCF Registry Study Paclitaxel-eluting Balloon Catheter Support C PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To collect post marketing surveillance data on consecutive patients with coronary heart disease intended to be or treated by the drug eluting Support C PTCA balloon catheter when used according to the Instructions for Use. Data will be collected in order to assess the long term safety and performance of the Support C Drug Coated Balloon (DCB) in routine clinical practice. |
FERNANDO ALFONSO; | 2025-03-01 |
| 59 | Early Cardiovascular Risk Assessment of Patients With COPD During Respiratory Exacerbation for The Identification and Treatment of Cardiovascular Comorbidity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a research study involving patients hospitalized for COPD flare-ups. Patients will be randomly assigned to two groups: one group will only see a pulmonologist (lung doctor), and the other group will also be seen by a cardiologist (heart doctor) during their hospital stay. Both groups will fill out a questionnaire, and the pulmonologist will review their lung disease, adjust their treatment, and recommend follow-up care. The cardiologist will also assess the second group for heart diseases (like high cholesterol, diabetes, heart disease, high blood pressure, … |
TEL AVIV SOURASKY MEDICAL CENTER | 2025-03-01 |
| 60 | Clinical Application Study of Wearable Multi-channel Electrocardiogram Acquisition Equipment in The Diagnosis of Myocardial Ischemia in Patients with Suspected Coronary Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Backgroud: With the widespread application of artificial intelligence, sensor technology, and wearable technology in clinical and daily life, wearable devices have shown a promising application prospect and tremendous potential. Currently, both domestic and international clinical applications of wearable ECG devices for the diagnosis and treatment of coronary heart disease are mostly single-lead ECG wearable devices or simulated multi-lead wearable ECG monitoring devices, … |
YONG HE; | 2025-03-01 |
| 61 | Inhibition of Small Conductance Calcium-Activated Potassium Current: A New Therapeutic Approach for Atrial Fibrillation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Afib is a common irregular heartbeat. Afib can cause stroke, blood clots, dementia and death. Medicines used to treat Afib often do not work well and can cause serious side effects. Clinicians need medicines that work better for Afib. Medicines for Afib work by blocking a current in the heart called a potassium current. There is a newer potassium current called IKas that can contribute to Afib. A medicine called ondansetron is used to keep people with cancer from getting sick to their stomach and throwing up. The investigators have found that ondansetron blocks IKas, … |
JAMES E. TISDALE; | 2025-03-01 |
| 62 | Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease: A Randomised Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate whether a management strategy based on coronary computed tomography angiography (CCTA) for patients with non-obstructive coronary artery disease can improve the LDL-C target achievement rate compared to a traditional management strategy without follow-up CCTA, thereby reducing the incidence of major adverse cardiovascular and cerebrovascular events over a 3 years period, including all-cause mortality, myocardial infarction, ischemia driven revascularation and stroke. |
ZHANG LONGJIANG; | 2025-02-28 |
| 63 | High Flow Nasal Cannula and Non-Invasive Positive Pressure Ventilation Following Extubation in Infants After Cardiac Surgery for Congenital Heart Disease: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study has the goal to determine the best method of respiratory support following extubation after cardiac surgery (CS). After cardiac surgery for Congenital Heart Disease (CHD), … |
ASAAD BESHISH; | 2025-02-27 |
| 64 | Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This will be an observational study to explore differences in pathophysiology between groups of people with and without heart failure (HF) (reduced and preserved ejection fraction) and with and without diabetes mellitus (DM) with a particular focus on cross-talk (fat, muscle, vascular tissue and the heart). The investigators will invite 600 people to partcipate (100 with HFrEF+DM, 100 with HFpEF+DM, 100 with HFpEF-DM, 100 with HFrEF-DM, 100 with DM, 100 without either HR or DM). Special heart scans, exercise testing, blood testing, testing of the automatic nervous system will be performed and in some, … |
KLAUS K WITTE; | 2025-02-26 |
| 65 | The CACHE Study: Coronary Artery Care in HaEmophilia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will use state-of-the-art imaging to look at heart disease in people with haemophilia. Haemophilia is an inherited disorder in which blood does not clot properly because of lack of a key ‘glue’ blood component (chemicals known as factor VIII or IX). People with haemophilia are 40% less likely to die of heart disease, but it is not known exactly why this is. Understanding heart disease in people with haemophilia is important because better treatments for haemophilia mean that these patients are now living longer, … |
SUSIE SHAPIRO; | 2025-02-25 |
| 66 | Clinical Implications of Three-vessel Ultrasonic Flow Ratio Measurement in Patients with Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, observational, single-center study. The main purpose of this study is to evaluate the diagnostic accuracy of offline computational ultrasonic flow ratio (UFR) in predicting functionally significant three coronary stenosis with conventional pressure wire-based fractional flow reserve (FFR) as the standard reference. The study will be conducted in Fuwai Hospital, … |
CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES | 2025-02-22 |
| 67 | Implementation of Heart Matters Evidence-based Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this non-randomized, propensity-matched-controlled study is to assess the effectiveness of the Heart Matters evidence-based program — previously evaluated for feasibility and efficacy in NCT02707432 — in improving cardiovascular health outcomes (change in systolic and diastolic blood pressure, primary outcomes) when implemented by community-based facilitators. |
GAURAV DAVE; | 2025-02-22 |
| 68 | Prospective Cohort Study of Prior Myocardial Infarction Identification on Electrocardiogram: The PRIME Cohort Study PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Abstract Background: Chronic myocardial infarction (MI) is a serious cardiovascular disease associated with high mortality rates, making early diagnosis and timely intervention essential for improving patient outcomes. However, some patients may present without clear symptoms or relevant medical histories, complicating the diagnostic process. Currently, diagnosis predominantly relies on electrocardiograms (ECGs) and imaging tests. Although cardiac magnetic resonance imaging (MRI) is regarded as the gold standard, its high cost and complexity hinder its clinical application. Consequently, … |
HANXIONG LIU; | 2025-02-20 |
| 69 | Reduce Tobacco Use in People Living With HIV in Switzerland: A Pragmatic Randomized Trial Within The Swiss HIV Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to test the effectiveness of offering a menu of different tobacco smoking substitutional products (e-cigarettes, nicotine pouches, nicotine patches in addition to usual of care) for smokers in the SHCS (Swiss HIV Cohort Study) in achieving self-reported 7-day tobacco cigarette abstinence at 6 months. |
MATTHIAS BRIEL; | 2025-02-20 |
| 70 | Assessing The Prevalence and Severity of Depression Among Coronary Artery Diseases Patients in Baghdad Using The PHQ-9: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational study aims to estimate the prevalence and severity of depression among patients with coronary artery disease (CAD) in Baghdad, Iraq, using the self-administered PHQ-9 questionnaire. The study seeks to answer the following questions: What is the prevalence of depression among CAD patients? How is the severity of depression distributed within this group? Are specific demographic, clinical, or environmental factors associated with higher levels of depression? Participants will: Complete the PHQ-9 to assess the severity of depressive symptoms at a specific point in time. Provide demographic and clinical information, including age, gender, socioeconomic status, comorbidities, … |
ABDUL-ILAH R. KHAMIS; | 2025-02-20 |
| 71 | Impact of Vitamin C Supplementation on The Hospital Length Stay in Children Undergoing Corrective Heart Surgery for Congenital Heart Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vitamin C will be given before admission in the immediate preoperative preceding 7 days (the dose 30 -45 mg per day ) in oral drops preparations Inflammatory markers including CRP , TLC ,PNI , GPS NLR will be checked on admission and on discharge and compared between cases and controls Hospital length stay will also be compared between the two groups |
HODA ATEF ABDELSATTAR IBRAHIM; | 2025-02-19 |
| 72 | Effectiveness of Self-Management of Blood Pressure on The Management of Resistant Hypertension PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The trial is a 12-month randomized, parallel-group study comparing three arms: (1) HBP self-management with AI chatbot support, (2) HBP self-management without AI chatbot support, and (3) usual care. The primary objective is to evaluate differences in blood pressure changes and medication compliance between groups at 6 and 12 months. |
TAICHUNG VETERANS GENERAL HOSPITAL | 2025-02-16 |
| 73 | Patients with Coronary Artery Disease or At High Cardiovascular Risk: Measuring Compliance with Treatment for Obstructive Sleep Apnea Syndrome (OAM or CPAP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obstructive sleep apnea (OSA) is a sleep disorder characterised by partial or total obstruction of the oro-pharyngeal carrefour during sleep. It is found in between 4% and 25% of the general population and in 40 to 80% of patients with cardiovascular diseases. Continuous positive airway pressure (CPAP) is the standard treatment for OSA and its efficacy has already been demonstrated in this particular population. However, this treatment is not always accepted or sufficiently tolerated. The mandibular advancement device (MAD) is therefore an alternative treatment for OSA, … |
UNIVERSITY HOSPITAL MONTPELLIER | 2025-02-14 |
| 74 | The Effect of Emotional FreedomTechnique on Postoperative Pain, Pain Belief and Anxiety in Coronary Artery Bypass Graft Planned Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: When the literature is examined, there is almost no application of EFT on surgical patients. In a quasi-experimental study conducted by Kalroozi et al. (2022) with 70 women who underwent breast cancer surgery and received complementary treatment, … |
ÖZGE İŞERI; | 2025-02-12 |
| 75 | Efficacy Comparison Between Primary Care Physicians’ Independent Auscultation and AI-assisted Auscultation for Congenital Heart Disease Screening in Patient-enriched Populations: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years, the application of artificial intelligence (AI) in the healthcare domain has witnessed a significant surge, with deep learning emerging as a potent force in the medical field. Deep learning algorithms possess the remarkable ability to automatically extract intricate features and patterns, thereby facilitating highly accurate heart sound recognition. Drawing on this technological advancement, Professor Sun Kun and his research team from Xinhua Hospital, in collaboration with numerous centers spanning across China, … |
KUN SUN; | 2025-02-10 |
| 76 | Invasive Hemodynamic Cardiopulmonary Exercise Testing for Assessment of Patients with Congenital Heart Disease (Cath CHD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between invasive hemodynamic assessments performed at rest versus exercise, to assess the correlation between invasive and noninvasive (Doppler-derived) rest-exercise hemodynamic indices and to compare the association between indices of disease severity and hemodynamic abnormalities identified at rest versus exercise. |
ALEXANDER C. EGBE; | 2025-02-10 |
| 77 | Clinical Classification and Prediction System of MAFLD Based on Liver Biopsy PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Metabolic dysfunction-associated Fatty Liver Disease (MAFLD), also known as Non-Alcoholic Fatty Liver Disease (NAFLD), is the most common chronic progressive liver disease in China. It is closely related to the high incidence of cardiovascular-renal-metabolic syndrome and both liver and non-liver malignancies, posing a serious threat to public health. However, the diagnostic criteria for MAFLD are not unified globally, and the classification and staging still rely on liver biopsy for pathological assessment. The characteristics, mechanisms, and predictive indicators of liver and extrahepatic disease outcomes in MAFLD patients are not yet clear. The severe form of MAFLD, metabolic dysfunction-associated steatohepatitis (MASH), … |
HONG YOU; | 2025-02-08 |
| 78 | Evaluation of Remnant Cholesterol Levels and Monocyte-to-HDL-cholesterol Ratio As Predictors of Coronary Artery Disease Severity in Patients with Acute Coronary Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Evaluation of serum level of remnant cholesterol and monocyte/HDL ratio as predictors of severity of coronary artery disease in patients with acute coronary syndrome. 2. Evaluate predictive value of remnant cholesterol serum level and monocyte/HDL ratio to detect in-hospital worse clinical outcomes and 45 days major adverse cardiac events (MACE) after acute coronary syndrome. |
ISAAC GHALY TAWFIK GIRGIS; | 2025-02-08 |
| 79 | Evaluation of The Feasibility of Support for The Management of Parental Stress in Surgical Resuscitation of Congenital Heart Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Half of children with congenital heart disease develop specific neurodevelopmental disorders. Neurodevelopmental disorders are the leading cause of morbidity in these children. They can be increased by perioperative complications, the family and economic socio-economic environment and the level of parental stress. The stress perceived by parents of children with congenital heart disease varies depending on the time of diagnosis, the organization of care inherent in neonatal management and the type of pathology diagnosed. The main objective is to evaluate the feasibility of a multidisciplinary and personalised model of support for parental stress, from the ante-natal period, … |
UNIVERSITY HOSPITAL BORDEAUX | 2025-02-06 |
| 80 | An Observational Study to Collect High Resolution 12-Lead Electrocardiogram (ECG) Data for The Development of An ECG Library to Support The Development of A Tool to Monitor Disease Progression, Gather Patient Perspectives on Standard of Care Heart Failure Procedures and Facilitate Familiarity with The Clinical Trial Environment in Patients with Heart Failure with Mildly Reduced or Preserved Ejection Fraction PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to establish an electrocardiogram (ECG) data library to facilitate future studies on heart disease. Additionally, the study will be used to monitor changes in the patient’s standard of care throughout the study period and gather patient perspectives on routine diagnostic procedures and disease monitoring and feedback on the design of heart failure trials. |
RICHMOND RESEARCH INSTITUTE | 2025-02-05 |
| 81 | Individually Tailored Digital Secondary Prevention After Hospitalization for Atherosclerotic Cardiovascular Disease: A Randomized Proof-of-concept Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality worldwide and in Norway. Approximately 50% of the patients admitted to hospitals with an acute ASCVD event has had a previous event. The high number of patients being readmitted to hospitals with new ASCVD events is to a large degree explained by poor control of established risk factors such as high LDL-cholesterol, high blood pressure (BP), diabetes, obesity, smoking, and lack of physical activity, as well as poor adherence to evidence-based medication. This pragmatic, … |
VESTRE VIKEN HOSPITAL TRUST | 2025-02-03 |
| 82 | Chronic Remote Ischemic Conditioning Combined With Mindfulness Therapy for Cardiovascular Adverse Events in Patients With Incomplete Revascularization of Coronary Artery Disease: A Multicenter, Double-blind, Randomized Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to demonstrate whether the combination of chronic remote ischemic conditioning and mindfulness therapy can reduce cardiovascular adverse events in patients with incomplete revascularization of coronary artery disease. |
MUWEI LI; | 2025-02-01 |
| 83 | EFFECT of PYRAMIDAL TRAINING on EPICARDIAL FAT for CORONARY ARTERY DISEASE PREVENTION PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To show the effect of pyramidal training for coronary artery disease prevention on: -Epicardial fat, BMI, Waist circumference (WC), Lipid profile, Quality of life and Mediterranean Diet Adherence. |
CAIRO UNIVERSITY | 2025-02-01 |
| 84 | Assessment of Depression, Anxiety and ADHD Among Children and Adolescents with Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart disease (CHD) is the most common birth defect, affecting ∼1% of all live births.The spectrum of CHD is wide, ranging from simple (not requiring immediate or possibly any surgical intervention) to severe or complex (typically defined as CHD requiring surgical intervention within the first month to year of life). |
SAMIA ASHRAF ABBDELGAWAD; | 2025-02-01 |
| 85 | Inflammation: A Key Contributor to Heart Disease and Diabetes? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate the inflammatory response associated with cardiometabolic diseases, and whether these can be reduced by ex vivo treatment with therapeutic agents. Briefly, … |
EMMA BÖRGESON; | 2025-01-30 |
| 86 | Effect of Hyperbaric Oxygen Therapy on Insulin Resistance in Postmenopausal Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: In postmenopausal females, Insulin resistance is commonly encountered in clinical setting. Hyperbaric oxygen therapy have been proposed effective in lowering blood glucose level and improving function. Identification of clinical examination variables as predictors to blood glucose levels and dysfunction would offer therapists the chance to undertake clinical decisions and consequently improve treatment efficiency. Objectives: This Predictive validity, diagnostic study conduct to examine the effect of hyperbaric oxygen therapy on insulin resistance in postmenopausal women. |
CAIRO UNIVERSITY | 2025-01-28 |
| 87 | Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in Steep Trendelenburg Position During Robot-assisted Prostatectomy, and Its Effect on Postoperative Cognition – A Clinical Blinded Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients scheduled for robot-assisted prostatectomy will be randomized to either high or low concentrations of carbon dioxide in the blood. This will be managed by applying different ventilation strategies during anesthesia.The levels will be distinctly different. The investigators will assess whether different concentrations of carbon dioxide in blood results in different brain blood flow levels and different intracranial pressure during laparascopic surgery in the head-down tilted position. The investigators also will assess if different carbon dioxide level will manifest in different cognitive abilities in the two study groups, measured on day 1 post-surgery. |
SIGNE SØVIK; | 2025-01-24 |
| 88 | Prospective Observational Multicenter Study of Patients With Arterial Hypertension and Chronic Kidney Disease Markers in Kazakhstan (PROGRESS-CKD) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicenter, non-interventional PRospective Observational study with retrospective analysis to describe the rate of CKD diaGnosis in patients with aRtErial hypErtenSion and CKD markerS in Kazakhstan |
ASTRAZENECA | 2025-01-20 |
| 89 | The Effect of Colchicine on The Occurrence of Atrial Fibrillation After Cardiac Surgery (CAFE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Development of a new comprehensive method for perioperative prevention of atrial fibrillation paroxysms in cardiac surgery patients at the hospital stage. It is planned to recruit 70 patients who will undergo pericardial fenestration during the operation using the original technique during coronary artery bypass grafting (Patent No. 2647626 C1 Russian Federation), and will be prescribed colchicine (the drug Colchicum-dispert) in the perioperative period in order to prevent the development of paroxysms of atrial fibrillation in the postoperative period, and 70 cardiac surgery patients operated on using the standard technique (without performing the pericardial fenestration procedure intraoperatively), … |
YURI Y VECHERSKY; | 2025-01-20 |
| 90 | Anatomical, Physiological and Inflammatory Characterization of The Non-Culprit Vessels in Patients Undergoing Primary PCI for ST-Elevation Myocardial Infarction in The Presence of Multivessel Disease Toward A Personalised Approach to Complete Revascularisation After Primary PCI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Most heart attacks occur because a clot forms in a coronary artery blocking blood flow. Without blood heart muscle dies. Untreated, clots can cause a specific type of heart attack -ST-elevation myocardial infarction (STEMI). STEMI patients are treated immediately by finding the blocked artery (culprit lesion) using a dye injected into the coronary arteries and then by unblocking the artery using balloons and stents. This procedure – primary angioplasty – … |
NICK CURZEN; | 2025-01-20 |
| 91 | Utilizing Exercise Cardiovascular and Skeletal Magnetic Resonance Imaging to Evaluate Factors Associated With Cardiorespiratory Fitness in Children With Acquired and Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function. |
MICHAEL KHOURY; | 2025-01-20 |
| 92 | Effects of ENavogliflozin on Coronary MicroVascular and Cardiac Function in Patients with ObesitY (ENVY) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to analyze the effects of enavogliflozin on heart function and coronary microvascular function in obese patients compared to a placebo, and to evaluate the improvement in cardiopulmonary exercise capacity in these patients. |
SEONG-MI PARK; | 2025-01-20 |
| 93 | Natural Heart Health Supplement Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We are running a 3-month trial of an experimental natural heart health supplement. Participants will take a daily dose of an experimental natural heart health supplement in powdered format, chocolate flavor. The trial will assess changes in heart biomarkers such as Total Cholesterol, HDL-C, LDL-C, Triglycerides, and High-Sensitivity C-reactive protein (hs-CRP). |
EFFORIA | 2025-01-15 |
| 94 | Tampere Coronary Artery Disease and Sudden Cardiac Arrest Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to recognize clinical and genetic risk factors for sudden cardiac arrest (SCA) and death (SCD) in patients with coronary artery disease (CAD). The main questions it aims to answer are: Are we able to recognize clinical or treatment-related risk factors for SCA or SCD? Can we identify new genetic risk factors for SCA or SCD in patients under 75 years? Participants diagnosed with CAD answer a short survey about their medical history and socioeconomic status. A standard ECG addition to a five (5) minute ECG recording is taken from all the study subjects. In addition to a few short physiological tests (e.g. blood pressure, height, weight, grip strength), a blood sample is withdrawn from a selected group of study subjects. Medical healthcare records are used to follow all study subjects, and no follow-up visits are required. |
JUSSI HERNESNIEMI; | 2025-01-13 |
| 95 | Performance Evaluation of Artificial Intelligence Screening Model in Coronary Heart Disease Detection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine whether an integrated AI decision support can save time and improve accuracy of assessment of obstructive coronary heart disease (CHD), the investigators are conducting a randomized controlled study of AI guided measurements of obstructive CHD probability compared to clinical assessment in preliminary evaluations by physicians. |
TIEN YIN WONG; | 2025-01-10 |
| 96 | Should We Avoid Performing Invasive Coronary Angiography Before Cardiac Surgery in ACHD (Adult Congenital Heart Disease) Patients? The SPARE Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare two pre-operative methods, that is the Invasive Coronary Angiography (ICA), an actual standard diagnostic method, with the Coronary Computer Tomography (CCT) to undestand if the only CCT is sufficent to confirm the presence of a significative coronary disease and so to identify possible lesions in the coronary ematic circle, for example: stenosis and narrowing of coronary vessels. This observational study included people who have a congenital heart desease with indication of cardiac surgery and, why this disease, … |
GABRIELE EGIDY ASSENZA; | 2025-01-08 |
| 97 | Cera™ ASD Occluder Post-Market Clinical Follow-Up Study：A Multi-Center, Single-arm, Ambispective Post-Market Follow-Up Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this post-market study is to: * collect real-word clinical data and confirm the long-time safety and performance of the Lifetech Cera™ ASD Occluder * identify previously unknown side-effects |
LIFETECH SCIENTIFIC SHENZHEN | 2025-01-03 |
| 98 | Combined Coronary CT Angiography and CT Perfusion in Coronary Artery Disease: Integrating Plaque Morphology, Hemodynamics, and Perfusion for Precision Management PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronary computed tomography angiography (CTA) provides high-resolution imaging of coronary artery disease (CAD), revealing stenosis, plaque characteristics, and hemodynamic markers like CT-derived fractional flow reserve (CT-FFR), axial plaque stress (APS), and wall shear stress (WSS). However, CTA alone has limitations in evaluating the functional significance of lesions, especially in cases with borderline stenosis, severe calcification, or coronary microvascular dysfunction (CMD). CT myocardial perfusion (CTP) complements CTA by directly assessing myocardial blood flow (MBF) and perfusion reserve (MPR), enhancing diagnostic accuracy. Despite its promise, … |
SHANGHAI ZHONGSHAN HOSPITAL | 2025-01-01 |
| 99 | A Prospective Trial to Assess Clinical Utility and Effectiveness of MyOme’s Polygenic Risk Score for Coronary Artery Disease (COMPASS-CAD) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to assess the benefit to physicians and patients of adding an integrated risk score (IRS) to existing coronary artery risk tools by conducting a randomized prospective study. IRS combines both an individual’s coronary artery disease (CAD) polygenic risk score (PRS) and clinical risk factors, like cholesterol levels and age. This study will examine to what extent IRS knowledge impacts physician/provider behavior as well as clinical outcomes including cholesterol levels and incident heart disease. |
MYOME | 2025-01-01 |
| 100 | Using Retinal Photograph Based AI to Predict Incident Coronary Heart Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine whether an integrated retinal AI decision support can improve predictive accuracy of coronary heart disease (CHD), the investigators are conducting a randomized controlled study of AI guided prediction of CHD compared to clinical prediction by physicians (e.g., usingPCEs), both using clinical intuition as baseline. |
TIEN YIN WONG; | 2025-01-01 |
| 101 | Predictive Value of Serum Albumin in Patients with Acute Coronary Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study aims to investigate the predictive value of serum albumin and short-term mortality in patients with Acute Coronary Syndrome (ACS) |
MAGDY ADEL ZAKI; | 2025-01-01 |
| 102 | Evaluation of The Efficacy (QCA) and Safety of The BioFreedom™ Ultra Drug Coated Stent in Patients with High Bleeding Risk and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to demonstrate that the BioFreedom™ Ultra Drug Coated Stent (DCS) is non-inferior to the BioFreedom™ DCS, with respect to in-stent late lumen loss, and that it has safety characteristics similar to the BioFreedom™ DCS. |
KAMARAJ A/L SELVARAJ; | 2024-12-18 |
| 103 | Using CTA Measures to Define Cardiac Risk In NFL Alumni PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The GAMEFILM Registry is a post-market, multi-center, data collection study assessing the presence of CAD in NFL alumni. |
JEFFREY BOONE; | 2024-12-17 |
| 104 | A Non-interventional, Prospective, Cross-sectional Study of The Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associated with The Post-acute Phase of The Infection By Sars-Cov-2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: More than 660 million cases of COVID-19 have been reported worldwide, with 183 million cases in the EU alone. In several people, after recovery, the effects of the first waves of COVID-19 persisted beyond the acute phase and increased the risk of chronic multiorgan symptoms and disease. Up to 70% of people affected by COVID-19 showed reduced organ function even four months or more after COVID-19 diagnosis. Such a functional decline is associated with an increased risk of the development of non-communicable diseases (NCDs). Thus, there is an essential need for a better knowledge, tools, … |
HELLENIC INSTITUTE FOR THE STUDY OF SEPSIS | 2024-12-10 |
| 105 | Genetic Characterization of Patients With Arrhythmia-Induced Left Ventricular Dysfunction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the genetic insights of arrhythmya-induced cardiomyopathy and its clinical prognosis. The main questions it aims to answer are: I. Does patients with arrhythmia-induced cardiomyopathy have a greater proportion of genetic mutations compared with other types of cardiomyopathy or general population? II. Have the genetics any prognostic impact in patients with arrhythmia-induced cardiomyopathy? |
MARTÍN NEGREIRA-CAAMAÑO; | 2024-12-01 |
| 106 | Effect of Ice-Bag Pressure, Transparent Radial Artery (TR) Band Compression Device-Screw, and Air Types on Early Complications and Patient Comfort After Radial Arterial Line Removal in Open Heart Surgery: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to find the different effects of applying an ice-bag pressure, TR radial band compression device-screw type, and TR radial band compression device-air type on early complications and comfort among patients undergoing radial arterial line removal after open heart surgery. |
ALI ABDUL-RASOOL ABBAS; | 2024-11-25 |
| 107 | Predictive Modelling of Clinically Significant Depressive Symptoms After Coronary Artery Bypass Graft Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of this project is to develop a predictive model for clinically significant depressive symptoms (CSDS) in patients undergoing coronary artery bypass graft (CABG) surgery, using pre- and perioperative data. CSDS occur in about 30 percent of CABG patients, which is four times higher than in the general population. These symptoms are linked to poor quality of life and increased morbidity and mortality. The aim is to create a model that can identify patients at risk for postoperative depression. This tool could help clinicians make informed decisions and take preventive measures to manage depression after surgery. |
ROLAND VON KÄNEL; | 2024-11-25 |
| 108 | A Single-Center, Open-Label, Randomized, Parallel Controlled Trial Evaluating The Effectiveness of Artificial Intelligence-Enhanced Management for Coronary Heart Disease (AIM-CHD) Delivered Via Mobile Application PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to find out if an artificial intelligence (AI)-enhanced mobile app can help people with coronary heart disease (CHD) better manage their health after being discharged from the hospital. The main questions it aims to answer are: 1. Does the AI-enhanced app help lower bad cholesterol (LDL-C) levels within 3 months after leaving the hospital? 2. Does the app improve other health measures, like blood pressure, blood sugar control, weight, medication adherence and cardiac events? Researchers will compare the AI-enhanced app to usual care, … |
CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES | 2024-11-23 |
| 109 | Registry Based Randomized Controlled Trial of Multiple Combination Strategies of Intensive Glycemic Control to Reduce A Composite of Macrovascular and Microvascular Events in Type 2 Diabetes With Cardiovascular Risk Factors (REMATCH Study) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Glycemic control is a mainstay of diabetes management to reduce the risk of microvascular complications and cardiovascular outcomes in people with type 2 diabetes (T2D). However, intensive control to near-normal glycated hemoglobin (HbA1c) yielded complex results in previous landmark trials. Potential risks of intensive glycemic control, such as hypoglycemia and weight gain, may partly contributed to the possible harms associated with this approach. Recent advances in diabetes management with development of newer antidiabetic drugs which minimize possible harms of intensive glycemic control as well as reduce cardiorenal risks enabled safer glycemic reduction. Thus, … |
KYU CHANG WON; | 2024-11-21 |
| 110 | Personalized Evaluation of Suspected Myocardial Ischemia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess whether the use of clinical risk models, known as Clinical Likelihood (CL) models, can reduce the need for diagnostic examinations without negatively impacting quality of life or prognosis after 12 months in patients with stable new onset chest pain. Additionally, the project will evaluate a newly developed method called Laser Speckle Contrast Imaging for measuring function and oxygen content in the smallest blood vessels (microvasculature) of the hand, which may also reflect blood flow and oxygen content in the microvasculature of the heart. |
GØDSTRUP HOSPITAL | 2024-11-20 |
| 111 | Role of Spectral CT in The Diagnosis of Myocarditis/MINOCA in Patients Undergoing CardioCT Investigations for Acute Chest Pain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It is a spontaneous, observational cross-sectional and single-center imaging (CT and MRI) study, coupled with clinical-laboratory data. Patients with acute chest pain with low/intermediate probability of coronary artery disease, ECG and/or troponin not diagnostic or altered according to the current standards of care used in the ED/Department (ESC Guidelines 2020), will be enrolled consecutively and will undergo CT examinations by means of Spectral CT technology. CT investigation will allow to identify any non-myocarditis causes of acute chest pain and by means of spectral analysis of CT images it will try to identify signs suggestive of damage myocardial (such as ECV, … |
VINCENZO RUSSO; | 2024-11-18 |
| 112 | Application of A Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate the impact of a clinical decision support system (CDSS) in children receiving mechanical ventilation (MV) after surgery for congenital heart disease (CHD). The main question it aims to answer is: -What is the impact of a CDSS designed to facilitate weaning and discontinuation of MV on the duration of MV in post-operative congenital cardiac surgery patients? Participants will be identified as eligible to initiate weaning from mechanical ventilation. Providers will decide whether or not to initiate weaning based on recommendations provided by the CDSS. Researchers will compare patients exposed to the CDSS with a historical cohort to see if the CDSS facilitated a decrease in MV duration. |
DANIEL HAMES; | 2024-11-18 |
| 113 | Telehealth-Enhanced Assessment and Management After Stroke-Blood Pressure (TEAMS-BP) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: TEAMS-BP is a Patient-Centered Outcomes Research Institute (PCORI)-funded trial under the Phased Large Awards for Comparative Effectiveness Research (PLACER) funding mechanism to evaluate two comprehensive and evidence-based strategies for managing blood pressure (BP) following stroke. |
CHERYL BUSHNELL; | 2024-11-15 |
| 114 | A Prospective, Multicenter, Self-controlled Clinical Trial to Validate Optical Ultrasonic Flow Ratio (OUFR) Based on Intravascular Imaging PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of is study is to validate a novel computational Fractional Flow Reserve (FFR) index method, termed Optical Ultrasonic Flow Ratio (OUFR), based on intravascular imaging including intravascular optical coherence tomography (OCT) and intravascular ultrasound (IVUS), using wire-based FFR as the gold standard. This is a prospective, multi-center, self-controlled clinical trial involving at least four medical centers and recruiting at least 114 subjects based on statistical power analysis. Participants undoing anticipated percutaneous coronary intervention will be performed: 1. Wire-based FFR measurement 2. Intravascular imaging, … |
YU BO; | 2024-11-10 |
| 115 | Seniors Integrated Longitudinal CardioVascular Evaluation of Coronary Heart Disease: A Multicenter, Prospective Registry in China (SILVER-China) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to establish a nationwide cohort and biobank of elderly patients with coronary heart disease (CHD) and to develop risk prediction models and clinical treatment optimization plans based on this data. The specific research content is as follows: The Study plan to continuously enroll hospitalized elderly CHD patients across 50 centers nationwide. Using networked electronic data collection technology, standardized methods and protocols will be used to gather demographic information (such as age, gender, education level, income, etc.), clinical information (medical history, past treatment records, current treatment plans, surgical records, medication use, etc.), lifestyle information (dietary habits, exercise frequency, … |
FUSUI JI; | 2024-11-06 |
| 116 | Sapphire 3 – A Prospective, Open Label, Multi-center, Single Arm, Observational Study Designed to Evaluate The Acute Safety and Device Performance of The Sapphire 3 0.85-1.25 Mm Coronary Dilatation Catheter in Predilatation of Chronic Total Occlusion (CTO) Lesions During Percutaneous Coronary Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, open label, multi-center, single arm, observational study designed to evaluate the acute safety and device performance of the Sapphire 3 0.85, 1.0 and 1.25mm diameter coronary dilatation catheter in predilatation of Chronic Total Occlusion (CTO) lesions during percutaneous coronary intervention. One hundred seventy (170) subjects will be enrolled with a target of one hundred fifty-three (153) evaluable subjects by the angiographic core laboratory at up to 15 clinical sites with the Sapphire 3 0.85, … |
DAVID KANDZARI; | 2024-11-06 |
| 117 | Evaluation of The Safety and Clinical Performance of The Biodegradable Polymer-Coated Sirolimus-Eluting Stent in All-Comer Patients With Multivessel Coronary Artery Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this registry is to evaluate the safety and clinical performance of the biodegradable polymer-coated Supraflex Cruz Sirolimus-eluting Stent (SES) in an unselected, all-comer patient population with multivessel disease. This population represents daily clinical practice and includes patients requiring coronary revascularization with drug-eluting stents (DES). |
NADHEM HAJLAOUI; | 2024-11-01 |
| 118 | The Modified Pills-in-the-Pocket Strategy -The Combined Effect of Amiodarone, Bisoprolol and Digoxin in The Treatment of Recurrent Atrial Arrhythmia for Non-Paroxysmal Atrial Fibrillation After Catheter Ablation: A Multicenter, Prospective, Randomized, Open-Label, Blinded Endpoint Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicentre, prospective, randomised controlled study of 328 patients with non-paroxysmal AF (within 5 years of first diagnosis of AF) with recurrent atrial arrhythmias after first catheter ablation, … |
YUMEI XUE; | 2024-10-23 |
| 119 | NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Blood Flow in Infants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates. For many years, the ultrasound group in Trondheim has been at the forefront in the development of new ultrasound technology for the diagnosis and monitoring of disease. Several methods previously developed in this research group are today widely used in hospitals around the world. In this project the investigators aim to test a new ultrasound technology that allows continuous monitoring of cerebral blood flow in sick neonates and pre-term children. This technology was CE-certified in October 2022, … |
SIRI ANN NYRNES; | 2024-10-20 |
| 120 | Using Life’s Essential 8 to Lower Heart Disease Risk in Midlife Black Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research seeks to improve the Midlife Black Women’s Stress Reduction and Wellness Intervention (B-SWELL), a program designed to lower heart disease risk in midlife Black women. The B-SWELL leverages stress reduction to facilitate the adoption and adherence to healthier lifestyle behaviors. This research study will use choice to increase engagement and minimize the effect of social determinants of health on research participation among midlife Black women. A comparative clinical trial will be conducted. Midlife Black women (ages 45-64) who reside in the Greater Cincinnati area will be recruited for participation. Women are eligible if they self-identify as Black/ African American, are between the ages of 45-64, and are willing to commit to the requirements of the study (e.g., attend 8 weekly sessions and 4 phone interviews). Participants will be randomly placed (like the flip of a coin) into either the B-SWELL or WE group. Both the B-SWELL and WE groups are 8-week programs that focus on healthy lifestyle behaviors and heart disease awareness. Women will have the choice to participate in person or virtually. Survey phone interviews will be conducted at baseline, 8-, 12-, and 16-weeks. Data collected will provide information about adherence, healthy lifestyle behaviors, and cardiovascular health. Heart health will be measured using the American Heart Association’s Life’s Essential 8 metric. Outcome measures include heart disease awareness, Life’s Essential 8 score, stress, self-efficacy, depressive symptoms, and symptoms. |
HOLLY JONES; | 2024-10-11 |
| 121 | Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting – A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to gain a better understanding of the association between brain changes and cognitive deficits in coronary heart disease (CHD) patients undergoing coronary artery bypass grafting (CABG) and whether a low-cost thiamine intervention can be used to reduce post-CABG cognitive issues in CHD subjects. |
RAJESH KUMAR; | 2024-10-10 |
| 122 | ICardia4HF: A Multi-component MHealth App and Tailored Text-messaging Intervention to Promote Self-care Adherence and Improve Health Outcomes in Patients with Chronic Heart Failure PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this factorial randomized trial is to examine the independent and synergistic efficacies of two mobile health technology interventions in people with chronic heart failure. The first intervention involves the use of multiple consumer mHealth apps and sensor devices (MyApps) for heart failure self-care (maintenance, monitoring, … |
SPYROS KITSIOU; | 2024-10-04 |
| 123 | Development and Clinical Application of A Foundational Model for Cardiovascular Disease Diagnosis and Prediction Based on Multimodal Medical Big Data PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to develop and evaluate the efficacy of a foundational model that integrates multimodal medical data to improve the diagnosis and prediction of cardiovascular diseases in patients aged 18 and older, including those with various heart conditions such as coronary artery disease, heart failure, and arrhythmias. The main questions it aims to answer are: Can a multimodal data-based diagnostic model match or exceed the accuracy of traditional gold-standard methods like coronary angiography, MRI, and echocardiography? Does integrating different types of data (ECG, imaging, … |
SHANGHAI ZHONGSHAN HOSPITAL | 2024-10-01 |
| 124 | The Prognostic Value of Positive Stress Echocardiography and Its Relationship with Invasive Coronary Angiography: The AMPHIPOLIS Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, multicenter, observational study of patients with recent stress echocardiography positive for myocardial ischemia. Up to now 25 echocardiography labs form Greece and Cyprus have declared their intention to participate. The investigators will enroll 390 patients with a positive stress echo, … |
NIKOLAOS KADOGLOU; | 2024-10-01 |
| 125 | A Multicenter, Prospective, Single-arm, Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this PMCF study is to: – confirm the safety and performance of the AcuMarkTM Sizing Balloon – identify previously unknown side-effects – monitor the identified side-effects (related to the procedure or to the medical devices) |
LIFETECH SCIENTIFIC SHENZHEN | 2024-09-24 |
| 126 | Effects of Wild Blueberry Consumption on Gut, Brain, and Cardiovascular Health in Non-Hispanic Black and White Adults with High Blood Pressure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure. |
RAFAELA G. FERESIN; | 2024-09-17 |
| 127 | Improving Care for Adults With Congenital Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The theory-informed digital health intervention, called as Empower My Congenital Health (EmpowerMyCH) aims to activate and engage ACHD patients in building confidence toward navigating the adult healthcare system. This tool is built after incorporating the theories of behavior change, gathering inputs from target patients in all stages of its design and implementation. The key features of the tool include a digital medical passport, updated congenital information, community support, and patient stories and advice. The investigators aim to test the acceptability, feasibility, efficacy, and effectiveness of the intervention. |
ANUSHREE AGARWAL; | 2024-09-05 |
| 128 | The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD). CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the progression of CKD so that fewer people develop kidney failure. CAPTIVATE provides a research platform that allows many treatment-related questions to be answered within a common trial set-up. |
THE GEORGE INSTITUTE | 2024-09-04 |
| 129 | Perioperative Interdisciplinary, Intersectoral Process Optimization in Heart Failure: A Multicenter, Prospective-randomized Intervention Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic heart failure affects up to three million people in Germany, with prevalence increasing with age. It is a leading cause of cardiovascular disease-related deaths. Patients with heart failure undergoing non-cardiac surgery face higher risks of complications and death compared to those with coronary artery disease. Despite guidelines recommending comprehensive preoperative evaluation, there is no systematic risk assessment structure in place, leading to inadequate perioperative care. This study aims to evaluate a multidisciplinary approach for high-risk patients aged 65 and above, regardless of prior heart failure diagnosis, … |
UNIVERSITY OF GIESSEN | 2024-09-01 |
| 130 | Distraction Therapy Using Virtual Reality in Patients Undergoing Cardiac Rehabilitation: Effects on Cardiac Efficiency, Anxiety and Exercise Tolerance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The European Society of Cardiology has been putting forward the need for new adjuncts or models that optimise outcomes from CR programmes. Immersive virtual reality (IVR) is one of the newest technologies whose input in CR is currently being investigated. It is a technology which helps simulate the real environment through a virtual one, allowing for interaction with the environment and to carry out exercise with variability, where intensity, repetition and feedback are key elements. It is reported that immersion in VR environments diverts the attention of the patient from unpleasant bodily sensations, … |
ANABEL SCIRIHA; | 2024-09-01 |
| 131 | NUTRITION MATTERS: A Food Is Medicine Intervention for African-American Adults With Multiple Chronic Conditions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: African Americans have higher rates of diabetes, obesity, heart disease, and high blood pressure. In addition, middle-aged non-Hispanic Black adults develop multiple chronic conditions (MCCs) at an earlier age, which share most of the same risk factors, including poor diet and physical inactivity. The major goal of the proposed project is to develop a culturally tailored intervention focused on improving awareness, knowledge, diet quality, and physical activity in a cohort of AA adults with MCCs. |
KRISTA D. SOWELL; | 2024-09-01 |
| 132 | Anesthetic Management in Patients Undergoing Epicardial Ablation for The Treatment of Ventricular Tachycardia; Retrospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a retrospective study and is descriptive in nature. In this study, the investigators aimed to emphasize the importance of anesthesia management by cardiac risk assessment of patients undergoing epicardial ablation under general anesthesia and analysis of complications that developed during the procedure. |
FERDA YAMAN; | 2024-08-30 |
| 133 | The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad and Tobago. The Pilot ECLIPSE Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties. This present study aims to explore the effects of colchicine on platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy. |
NAVEEN SEECHERAN; | 2024-08-21 |
| 134 | Potential Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patients With Structural Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective comparative study, conducted at Cardiology Department, Aswan University Hospital on AF patients with structural heart disease. Eplerenone 25 mg daily will be given and searching for AF recurrence among study population. |
AHMED ABDELGALEEL; | 2024-08-10 |
| 135 | Safety, Efficacy and Tolerability of Bowel Preparation and Colonoscopy in Patient With Chronic Heart Disease, Chronic Kidney Disease and Chronic Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Consecutive eligible patients will be enrolled and written informed consent will be obtained from all participants. Routine blood investigations will be sent. Patients with chronic heart failure will be classified based on ejection fraction into 2 groups (EF \ 40%), patients with chronic kidney disease will be classified based on KDIGO classification system into grade I-V. Patients with chronic liver disease will be classified according to the child pugh scoring system into three groups (Child A, B and C). All patients will be undergo bowel preparation under supervision. The patients will be given 10 mg of bisacodyl, … |
MOHAN RAMCHANDANI; | 2024-08-10 |
| 136 | Multimodal Omics and Imaging Study on The Mechanisms of Brain-heart Injury in Patients With Intracranial Hemorrhage PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia, brain edema, and hydrocephalus. Complications such as cardiac injury may also arise, categorizing them within the cerebrocardiac syndrome (CCS). The clinical spectrum of CCS encompasses acute myocardial injury, acute coronary syndrome, left ventricular systolic and diastolic dysfunction, cardiac arrhythmias, and sudden cardiac death, all of which are associated with increased mortality and deterioration in patient status. The precise pathophysiological mechanisms underlying both cerebral and cardiac injuries remain enigmatic, … |
YONG CAO; | 2024-08-01 |
| 137 | Promoting Cardiovascular Disease Awareness and Cardiovascular Health Among Minnesota State Fair Attendees: The Great Minnesota Heart Health Check PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective is to increase awareness of various cardiovascular diseases (CVDs) through an interactive, educational experience to promote cardiovascular health (CVH) via an inflatable heart model exhibit and assess community CVD knowledge and whether this experience is an acceptable tool to promote and provide education on CVH. |
LAPRINCESS C. BREWER; | 2024-08-01 |
| 138 | Breathing New Life: The Impact of Incentive Spirometer Training on Rehabilitation and Health in Type 2 Diabetes With Sarcopenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In patients with Type 2 diabetes, the risk of developing sarcopenia is three times higher compared to individuals with normal blood sugar levels. Sarcopenia is often accompanied by reduced physical activity, immobility, slow gait, and poor endurance. More importantly, previous studies have shown that sarcopenia leads to a decrease in mobility, which in turn results in reduced cardiopulmonary function, difficulty in breathing, and subsequently even less activity. In diabetic patients, this can cause poor control of blood sugar and lipids, as well as sarcopenic obesity, creating a vicious cycle. Therefore, … |
YU-SHAN HSIEH; | 2024-08-01 |
| 139 | Cross-sectional Cohort Analysis of Plasma Proteomics in Coronary Artery Disease and Plasma Metabolomics in Coronary Artery Disease: Comparative Study Between Patients with Obstructive (≥ 50%), Non-obstructive (< 50%) and No Lesions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The presence and clinical evolution of coronary atherosclerosis depend on various classic risk factors and biomarkers. However, the search for more specific markers is necessary, especially for individuals with non-obstructive coronary artery disease, lesions \< 50%. In this regard, the field of plasma proteomics could enable the discovery of these novel biological indicators. To evaluate and compare the differences in the proteomic profile among three groups of individuals, namely those without atherosclerotic lesions, those with non-obstructive lesions in coronary flow (\< 50%), and those with obstructive lesions (e 50%), ... |
PROTASIO DA LUZ PHD; | 2024-08-01 |
| 140 | Comorbidities and The Management of Hypertensive Heart Disease in A Low-Resource Setting: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this Cross-sectional study, we will analyzed data from a tertiary referral Congolese hospital to find whether or not Congolese patients with hypertensive heart disease have multiple comorbid conditions. Will report on the management and outcomes of the patients. |
RAÏSSA K KONGUE; | 2024-07-26 |
| 141 | Neutrophil-to-Lymphocyte Ratio AND C-REATIVE PROTEIN Useful As Cost-Effective Preliminary Prognostic Markers in ST-Elevation Myocardial Infarction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute myocardial infarction (AMI) is a serious and fatal cardiovascular emergency and considered the leading cause of mortality worldwide. Atherosclerosis of coronary arteries which takes decades to manifest clinically, is the primary predisposing pathologic factor responsible for the development of coronary heart disease It has been shown that A complex immune and inflammatory pathophysiological process is thought to be crucial for in the initiation and progression of atherosclerotic plaques. Inflammation is one of the main mechanisms in the pathogenesis of atherosclerosis , Destabilization of chronic artery plaques and development of thrombosis, … |
ALBIER YOUSSEF KAISER; | 2024-07-01 |
| 142 | The Role of Colchicine As Anti-Inflammatory Treatment in Patients With HFpEF: A Prospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure with preserved ejection fraction (HFpEF) is a condition associated with high morbidity and mortality. Chronic low-grade inflammation plays a key role in its progression, yet few treatments specifically target this pathway. This clinical trial aims to evaluate the effectiveness of colchicine, a well-tolerated anti-inflammatory drug, in reducing inflammation in HFpEF patients. The study will assess whether colchicine lowers levels of soluble ST2 (sST2), a biomarker linked to inflammation and cardiac stress in HFpEF. Participants will take colchicine daily for three months, … |
SHAIMA MOHAMMED ABDULLAH ZEYAD; | 2024-07-01 |
| 143 | Development and Polit Study of An Intervention Program to Enhance The Transition Readiness of Adolescents With Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if the Get Ready with my Heart Program developed based on SMART theory is applicable for AYAs with CHD to enhance their Transition Readiness. The main questions it aims to answer are: 1. Is the Get Ready with my Heart Program clinically feasible？ 2. Does the Get Ready with my Heart Program improve participants’ Transition Readiness? Participants will: 1. The intervention group will receive interventions according to the Get Ready with my Heart Program, … |
CHILDREN’S HOSPITAL OF FUDAN UNIVERSITY | 2024-06-26 |
| 144 | Special Drug Use Investigation of Rivaroxaban in Pediatric Patients With Congenital Heart Disease (CHD) Who Had Undergone The Fontan Procedure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study in which the data from children with congenital heart disease will be collected and studied. These children will include those who are prescribed rivaroxaban by their doctors after a heart surgery called the Fontan procedure. Congenital heart disease (CHD) is a heart problem that some children are born with. It sometimes requires a surgery called the Fontan procedure to improve the blood flow in the body. The Fontan procedure can increase the risk of the formation of blood clots in the blood vessels (called thrombosis), which might lead to death. The study drug, rivaroxaban, … |
BAYER | 2024-06-18 |
| 145 | Effectiveness of Smartphone Based Tele-rehabilitation on Cardiovascular Functional Capacity and Sleep Quality Among Coronary Heart Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effectiveness of smartphone based tele-rehabilitation on functional capacity and sleep quality among coronary heart disease patients. |
MUHAMMAD IQBAL TARIQ; | 2024-06-15 |
| 146 | Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus Histidine, Tryptophan and Ketoglutarate Solution Cardioplegia Solution in Cardiac Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Low chloride solutions were proved to be better in resuscitation of emergency cases and decrease the resulting hyperchloremic metabolic acidosis in the last decade. In ringers’ acetate solutions, there is acetate, which is metabolized in muscles to produce bicarbonate molecules, so neutralizing the ongoing lactic and hyperchloremic metabolic solutions. Both solutions were proved to be superior to normal saline as a fluid therapy plan in most studies with much less ongoing hyperchloremic metabolic acidosis and inflammatory response. In this protocol, … |
AYMAN ABD EL-KHALEK MOHAMMED GLALA; | 2024-06-01 |
| 147 | The Effect of The Combination Therapy of Statin and SGLT2i in The Treatment of Ischemic Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: correlate the serum level of statin and SGLT2i when given as polytherapy with HPLC in ischemic heart failure patients and their laboratory tests (cholesterol, LDL, HDL and TG…) |
ASMAA MOHAMED ABDELKADER; | 2024-06-01 |
| 148 | Risk of Falling Assessment in A Population of Patients With Cardiovascular Diseases Undergoing Cardiac Rehabilitation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Rationale Cardiac rehabilitation (CR) is a key intervention for patients with chronic heart disease or recent acute cardiovascular events. In elderly and frail patients, CR aims not only to improve functional capacity but also to maintain or recover independence in daily activities. Hospitalization following an acute event often leads to bed rest, which-even after just 2-3 days-can cause hypokinetic syndrome, characterized by loss of muscle tone, orthostatic hypotension, decreased mobility, and psychological decline, including depression. Moreover, immobility increases thrombotic risk and vascular complications. To mitigate these effects, … |
IRCCS SAN RAFFAELE ROMA | 2024-05-31 |
| 149 | Effect of Xuesaitong Soft Capsules on Major Risk Factors in Patients With Coronary Heart Disease: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This trials aims to assess, in 240 eligible patients with coronary heart disease, the effects on level of high-sensitivity C-reactive protein (hsCRP) changes from baseline to 12 weeks of Xuesaitong Soft Capsules. |
JING LI; | 2024-05-31 |
| 150 | CSP #2026 – Beta Blocker Dialyzability on Cardiovascular Outcomes (BRAVO) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability. |
VA OFFICE OF RESEARCH AND DEVELOPMENT | 2024-05-22 |
| 151 | Normothermic Versus Hypothermic Cardiopulmonary Bypass in Adult Cardiac Surgery: A Multicentre Feasibility Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In order to perform heart surgery, a machine called cardiopulmonary bypass (CPB), or more commonly known as a heart-lung machine, is used to maintain the circulation of oxygenated blood needed by the rest of the body and its organs. Historically, when a patient is connected to CPB, their body is cooled below the normal body temperature. This is known as hypothermia. This is because scientific studies have previously shown that reduced body temperature lowers metabolism and therefore offers more protection to the brain and other organs due to the reduced oxygen requirement. The evidence supporting this practice, however, … |
UNIVERSITY OF LEICESTER | 2024-05-20 |
| 152 | Finerenone Research of Outcomes and Drug Utilization PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study, in which data from people in Japan and in the United States with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied. The participants in this study are already receiving the study treatment finerenone as part of their regular care from their doctors. In observational studies, only observations are made without specified advice or interventions. CKD is a long-term progressive decrease in the kidneys’ ability to work properly. In people with T2D, the body does not make enough of a hormone called insulin, … |
BAYER | 2024-05-15 |
| 153 | Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease. |
ANAND VAIDYA; | 2024-05-15 |
| 154 | Evaluation of The Validity and Reliability of The BETY-Biopsychosocial Scale in Individuals With Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Scales for biopsychosocial assessment of coronary artery disease patients are limited. The aim of this study was to evaluate the validity and reliability of the Cognitive Exercise Therapy Approach-Biopsychosocial Questionnaire (BETY-BQ) in patients with CAD. |
EBRU CALIK KUTUKCU; | 2024-05-10 |
| 155 | Detection of Valvular Heart Disease Using Artificial Intelligence-based Stethoscope PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to develop a deep learning-based application of heart sounds in the diagnosis of valvular heart disease, which can be used to screen patients with valvular heart disease and promote earlier clinical monitoring and intervention. |
XIAO-DONG ZHUANG; | 2024-05-01 |
| 156 | Alabama Womb 2 Heart Solution (AW2H): A Community Health Worker Intervention to Improve Short- and Long-term Outcomes in Black Patients With Preeclampsia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: United States maternal mortality and preterm birth rates are among the highest among high-income countries due in part to a combination of racial, regional and socioeconomic disparities in access to care and overall health. The research proposed focuses on adapting and expanding a perinatal community health worker intervention for Black postpartum patients with preeclampsia (PE). Investigators will partner with a community-based organization that trains and deploys community health workers. Investigators will test an intervention for urban and rural Black postpartum patients with PE to 1) enhance blood pressure control postpartum and 2) promote long-term cardiovascular disease prevention for this underserved population. This pilot study will determine if randomizing and implementing a community health worker intervention tailored to pregnant people experiencing preeclampsia is feasible and found to be acceptable by participants. |
JESSE RATTAN; | 2024-05-01 |
| 157 | A Comparative Study Between General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present study is to compare between general anesthesia versus sedation with dexmedetomidine and ketamine with local infilteration at the catheter insertion site in pediatric patients undergoing transcutaneous closure of atrial septal defect on hemodynamic changes. |
AYA EBRAHIM ABDELHAFEZ MASHAL; | 2024-05-01 |
| 158 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate The Effect of Retatrutide on The Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 Kg/m2 and Atherosclerotic Cardiovascular Disease And/or Chronic Kidney Disease PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor. |
PHILLIP MADONIA; | 2024-04-30 |
| 159 | A Randomized Double-blind, Placebo-controlled, Multicenter Study to Evaluate The Efficacy, Safety and Tolerability of Pelacarsen (TQJ230) in US Black/African American & Hispanic Patient Populations With Elevated Lp(a) and Established Atherosclerotic Cardiovascular Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study CTQJ230A12303 is a randomized, double-blind placebo-controlled, Phase IIIb study to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) 80 mg s.c. QM compared with placebo s.c. QM in US Black/African American and Hispanic participants with established ASCVD and elevated levels of Lp(a) who are treated for cardiovascular (CV) risk factors according to local practice/guidelines for the reduction of cardiovascular risk. |
WILLIAM KIRBY; | 2024-04-24 |
| 160 | The Effect of Early Cardiopulmonary Telerehabilitation on Exercise Capacity, Cardiac Function, Quality of Life and Emotional Status in Coronary Bypass Surgery Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to investigate the effects of phase I and early phase II rehabilitation with telerehabilitation method and sleep hygiene training on physical capacity, cardiac functions, anxiety level, quality of life and sleep quality in patients undergoing coronary artery bypass graft surgery. |
MUAMMER CORUM; | 2024-04-20 |
| 161 | Observational Cohort Study of Adult Patients With Congenital Heart Disease PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this retrospective and prospective single-center observational study is to evaluate the correct management of adult patients with congenital heart diseas (ACHD), based on the experience of a reference center such as the Institute of Pediatric Cardiology at Policlinico Sant’Orsola Malpighi. The patients participating in this study will not be subjected to any procedures beyond normal daily clinical practice; likewise, … |
GABRIELE EGIDY ASSENZA; | 2024-04-18 |
| 162 | MagicTouch Sirolimus-coated Balloon for Treatment of In-Stent Restenosis in Coronary Artery Lesions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Superiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus- Coated Balloon in the Treatment of Coronary Drug-Eluting Stent In-Stent Restenosis. Subjects with prior DES implantation presenting with ISR lesions undergoing PCI will be randomized into two groups: treatment with the MagicTouch™ sirolimus-coated balloon or POBA on a 2:1 basis. Approximately 492 subjects will be enrolled in the randomized study in a maximum of 50 study sites located in the United States. The goal is to establish the safety and efficacy of the MagicTouch™ sirolimus- … |
CONCEPT MEDICAL | 2024-04-16 |
| 163 | Technical Development of Cardiovascular MRI PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: In the U.S., over 6.5 million people have heart failure. Researchers want to develop new testing methods for cardiovascular problems using magnetic resonance imaging (MRI) to improve the clinical diagnosis and management of people with heart failure. Objective: To develop and test new methods for imaging the heart and blood vessels using MRI. Eligibility: People ages 18 years and older who are having an MRI of their heart or blood vessels. Healthy volunteers are also needed. Design: Participants will be screened with a medical history. Participants will have a physical exam and blood tests. They will have an electrocardiogram (ECG) to measure the heart s electrical activity. Then they will have their scheduled MRI scan. The MRI scanner is a large, hollow tube. Participants will lie on a table that moves in and out of the tube. During the MRI, they may have contrast dye injected through an intravenous line inserted into their arm or hand. ECG may be used to monitor their heartbeat or coordinate pictures with their heartbeat. A flexible belt may be used to monitor their breathing. A finger probe may be used to track their heart rate and/or oxygenation level. Their blood pressure may be measured. Pictures may be taken of their blood vessels, heart, and lungs before, during, and after they get medicine to increase blood flow. They may lie flat and pedal a stress bicycle to increase their heart rate. Participation will last for 5 years. During that time, participants may receive a yearly survey about their health. They may be contacted for an optional follow-up MRI within 2 years of their MRI. |
ERIC E MORGAN; | 2024-04-08 |
| 164 | Association Between Triglycerides Glucose Ratio With HOMA -IR As Indicators of Insulin Resistance in Obese Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present study was to investigate the correlation between the triglyceride/glucose index (TyG index) and homeostasic model assessment of insulin resistance (HOMA-IR) to predict insulin resistance (IR) in obese adults |
AYAT ESMAT MOHAMED KOTB; | 2024-04-01 |
| 165 | Effectiveness of Chronic Self-management Education on Behavioral and Clinical Outcomes of Patients With Rheumatic Heart Disease at Jimma Medical Center (JMC): A Pseudo Quasi Experimental Design PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study Design, Setting, and Period A one-group quasi-experimental study using a pre-test and post-test will be implemented on a convenient sample design to examine the effectiveness of chronic disease self-management education in improving clinical outcomes and decreasing depression and anxiety among patients under medical follow-up at Jimma Medical Center cardiac clinic. A comprehensive evaluation of both clinical and laboratory measurements will be conducted before and after the education intervention. Education will be provided monthly, four times (at 30, 60, 90, and 120 days), with data collection occurring over four months. Sample Size, Sampling Technique, … |
HIWOT BERHANU; | 2024-04-01 |
| 166 | Clinical Audit on The Use of Antiarrhythmic Drugs in Pediatric Age Group PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A study on the use of antiarrhythmic drugs in pediatric age group, in Assiut University Children’s Hospital, a clinical audit |
REHAM ABDEL-AZIZ MOHAMED; | 2024-04-01 |
| 167 | Study of Percutaneous Coronary Intervention in Left Main Coronary Artery Disease in Patients With Acute Coronary Syndrome at Sohag University Hospitals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute coronary syndromes (ACS) encompass a spectrum of cardiovascular disorders characterized by the sudden onset of myocardial ischemia. They are primarily caused by atherosclerotic plaque rupture or erosion, leading to partial or complete occlusion of the coronary arteries. Among the various coronary arteries affected, left main coronary artery disease (LMCAD) is of particular concern due to its high anatomical significance and potential for adverse outcomes The left main coronary artery (LMCA) is responsible for supplying a substantial portion of the left ventricular myocardium, … |
MOHAMMED BAHAA ELDEEN ELSAYED; | 2024-04-01 |
| 168 | Development of A Culturally Tailored Resilience-Building Intervention to Facilitate Advance Care Planning Discussions Between Chinese American Patients and Their Family Caregivers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Less than 15% of Chinese Americans complete advance directives. That is less than half of the 37% completion rate in the US general population. This disparity in the use of advance care planning between White Americans and Chinese Americans may extend to disparities in end-of-life care. To address such disparities in end-of-life care, we will develop and assess the acceptability of a culturally tailored resilience-building intervention to help Chinese Americans with cancer or heart disease and their family caregivers engage in advance care planning discussions. |
UNIVERSITY OF ILLINOIS AT CHICAGO | 2024-04-01 |
| 169 | Efficacy and Safety of Echocardiography-guided Percutaneous Intraventricular Septal Radiofrequency Ablation for Obstructive Hypertrophic Cardiomyopathy After Alcohol Septal Ablation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After alcohol ablation, some HOCM patients have serious clinical symptoms and adverse complications, and need to undergo invasive surgery again when adequate drug therapy is not effective or cannot tolerate the side effects of drugs. Liwen surgery is a safe and effective new minimally invasive treatment for HOCM patients, so the purpose of this study was to evaluate the safety and efficacy of Liwen surgery in HOCM patients who failed alcohol ablation and provide new treatment methods for patients. |
LIU LIWEN; | 2024-03-26 |
| 170 | A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess The Efficacy and Safety of A 12-week Administration of OATD-01, An Oral Inhibitor of Chitinase-1 (CHIT1), for The Treatment of Active Pulmonary Sarcoidosis (the KITE Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2, randomized, double-blind, placebo-controlled, adaptive, multicenter study to evaluate the efficacy, safety, tolerability, Pharmacodynamics (PD), and Pharmacokinetics (PK) of OATD-01 in the treatment of subjects with active pulmonary sarcoidosis. |
MOLECURE S A | 2024-03-21 |
| 171 | Middle-aged Women With Adverse Pregnancy Outcomes and Heart Failure With Preserved Ejection Fraction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Due to the steady increase in the burden of HFpEF, especially in women, it is an important task to search for new markers and early predictors associated with the development of this disease. Nowadays, the relationship of adverse pregnancy factors with the development of long-term cardiac pathology, in particular, HFpEF, … |
MAX SHPERLING; | 2024-03-18 |
| 172 | Potential Effect of Niacin on Lipoprotein (a) Concentration and Hyperphosphatemia in End-Stage Renal Disease Patients Undergoing Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if Niacin has an effect on lipoprotein (a) concentration and hyperphosphatemia, which represent strong risk factors for cardiovascular diseases, in End-stage renal disease (ESRD) patients undergoing hemodialysis. It will also learn about the safety of Niacin. The main questions it aims to answer are: – Does Niacin lower lipoprotein (a) concentration? – … |
AMIRA REDA MUHAMMAD GALAL; | 2024-03-15 |
| 173 | Using OFR Software to Observe The Effects of Inclisiran Combined with Statins on The Morphology and Vascular Function of Coronary Vulnerable Plaques PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Effects of inclisiran + statins vs. statins on the morphology and vascular function of coronary vulnerable plaques, in order to provide a better treatment and more detailed imaging basis for the treatment of coronary vulnerable plaques. |
CHINA JIANGSU; | 2024-03-15 |
| 174 | VIsualization of Coronary Artery Disease for Modification of RISK Factors. Prevention of Disease Progression in Patients With Non-Obstructive Coronary Atherosclerosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol lowering medications, and modify the coronary artery disease phenotype over 12 months. |
BJARNE LINDE NØRGAARD; | 2024-03-12 |
| 175 | A Randomized Comparison of Cleerly Coronary Artery Disease Stage-Based Care Versus Risk Factor-Based Care for Primary Prevention of Cardiovascular Events PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease (CAD) Staging System-based care strategy reduces CV events compared with risk factor-based care. |
STEVE SIMON; | 2024-03-06 |
| 176 | Coated or Chewable Aspirin in Patients with Established Atherosclerotic Disease and A Hybrid Strategy to Mitigate The Adverse Effects of Air Pollution: The COATED-AIR Randomized Clinical Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Although both enteric-coated and plain formulations of aspirin are being used commonly, there are no high-quality comparisons between these formulations with respect to clinical efficacy outcomes in patients with atherosclerotic cardiovascular diseases (ASCVD). Air pollution is also a major contributor to the excess risk of cardiovascular events in many regions of the world. However, … |
PARHAM SADEGHIPOUR; | 2024-03-06 |
| 177 | Myocardial Perfusion Quantification With Single Photon Emission Computed Tomography Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary Computed Tomography Angiography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective study aims to compare functional abnormalities detected using myocardial perfusion SPECT imaging (MPI SPECT) with the extent and severity of anatomical findings on coronary computed tomography angiography (coronary CTA). Additionally, … |
MAUROVICH-HORVAT PÁL; | 2024-03-06 |
| 178 | Artificial Intelligence-enhanced Electrocardiogram Diagnoses and Predicts Future PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective study to establish models for the prediction of future valvular heart diseases with artificial intelligence-enhanced electrocardiogram (ECG). |
SHANGHAI ZHONGSHAN HOSPITAL | 2024-03-01 |
| 179 | A Comparison of Multidetector Computed Tomography and Transthoracic Echocardiography in The Diagnosis of Congenital Cyanotic Heart Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multi-detector computed tomography angiography (MDCTA) provides high-resolution images of the heart and its vasculature, allowing for accurate anatomical assessment, detection of complex cardiac morphology, |
MUHAMMAD NAVEED BABUR; | 2024-03-01 |
| 180 | A Prospective, Multicenter, Open-label, Randomized, Comparative Clinical Trial to Verify The Effectiveness, Safety, and Cost-effectiveness of AI-Gatekeeper, A Multimodal AI Software, in Assisting The Screening of Coronary Artery Stenosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the efficacy, safety, and cost-effectiveness of AI-Gatekeeper software to assist clinicians in the diagnosis of coronary artery disease by predicting coronary artery stenosis (≥50%) from a multimodal AI technology that integrates clinical risk factors and baseline blood tests, including chest X-ray, electrocardiogram, and echocardiogram, in patients with suspected coronary artery disease (coronary stenosis). |
IN HYUN JUNG; | 2024-03-01 |
| 181 | Using The Visualization for Lifestyle Change in Patients at Risk of Cardiovascular Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In the framework of PhD research, we will present a visualization of estimation of CVDs risk and the possibility of monitoring blood glucose levels in real-time. Based on the results, we will assess the association of these with lifestyle change. The findings highlight the need for sufficiently reliable and high-quality evaluations of visualizations, technologies or applications used in the family medicine. |
ADRIJANA SVENSEK; | 2024-03-01 |
| 182 | Relation of Helicobacter Pylori Infection in Patients With Impaired Glucose Tolerance and Their Lipid Profile in Upper Egypt PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to : find the relation between H.pylori infection and pre-diabetic patients with lipid profile . Specifically, the study aims to: 1. affect of H.pylori infection in pre-diabetic patients 2. realation between Pre-diabetic patient and lipid profile 3. Risk factor of H.pylori infection in pre-diabetic patients D)HbA1C test measures your average blood sugar level over the past 2 or 3 months. e)Fasting Blood Sugar Test. f) the IgG antibody of h.pylori. |
KHALED MAHMMOUD IBRAHIM; | 2024-03-01 |
| 183 | Effects of Aerobic Exercise on Kinesiophobia, Functional Capacity and Quality of Life in Obese Patients With Atherosclerotic Cardiovascular Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is classified using body mass index (BMI) (BMI ≥25 overweight, BMI ≥30 obese, BMI ≥40 morbidly obese). Obese patients are Class 1 according to BMI; BMI:30-34.9 and Class 2; BMI: It is classified as 35-39.9. Patients with classes 1 and 2 will be included in the study. Obesity can be accompanied by comorbidities such as atherosclerotic vascular and cardiac pathologies, hyperlipidemia, hypertension, coronary artery disease, diabetes mellitus, so obesity treatment should be managed multidisciplinary. The basic approach to obesity treatment is diet, exercise, medical treatment, treatment of comorbid conditions and surgery. Aerobic exercise therapy, … |
HAVVA TALAY ÇALIŞ; | 2024-03-01 |
| 184 | Effect of Acupressure on Anxiety, Pain and Vital Signs in Individuals Diagnosed With Acute Coronary Syndrome: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to examine the effect of acupressure on physiological parameters and anxiety levels in individuals diagnosed with Acute Coronary Syndrome (ACS). H1-1: Acupressure applied to individuals diagnosed with ACS has an effect on the level of anxiety. H1-2: Acupressure applied to individuals diagnosed with ACS has an effect on blood pressure. H1-3: Acupressure applied to individuals diagnosed with ACS has an effect on heart rate. H1-4: Acupressure applied to individuals diagnosed with ACS has an effect on respiratory rate. H1-5: Acupressure applied to individuals diagnosed with ACS has an effect on the pain level. H1-6: Acupressure applied to individuals diagnosed with ACS has an effect on cortisol levels. |
SAADET CAN ÇIÇEK; | 2024-03-01 |
| 185 | The Role of Thiamine on Left Ventricular Structure and Function After Transcatheter Closure Through The Examination of MMP-9 Dan TIMP-1 in Children With Left-to-Right Shunt Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Currently, research on the effect of thiamine administration during transcatheter closure on the structure and function of the left ventricle by examining levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in children with left to right shunt congenital heart disease has never been carried out in Indonesia, so it is necessary carried out this research. This research was carried out by administering 100 mg of thiamine once per day to patients post transcatheter closure for 28 days. The parameters assessed were MMP-9, TIMP-1, … |
PUTRI AMELIA; | 2024-03-01 |
| 186 | Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP) Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the role of coronary CT angiogram (CCTA) as a superior guide for the assessment of coronary artery plaque and guiding treatment decisions. The investigators also assess the impact of preventive cardiovascular drugs on the plaque to improve patient outcomes. Participants aged 18-80 years, at intermediate or high-risk for coronary artery disease, with non-obstructive plaque on initial CCTA, … |
DINESH KALRA; | 2024-03-01 |
| 187 | PREVAIL Paclitaxel-coated Balloon in Small Coronary Disease and High-bleeding Risk Patients PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-market, prospective, observational, multicenter, non-intervention study, to demonstrate the effectiveness of drug-coated ballon (DCB)therapy in real-world patients with small native vessel coronary artery disease, and to demonstrate the safety of short dual antiplatelet therapy (7 days) in high-bleeding risk patients with native small vessel coronary artery disease treated with DCB therapy. A percutaneous coronary intervention (PCI) with DCB will be performed in patients with native vessel coronary artery disease based on the criterion of the treating physician. |
FUNDACIÓN EPIC | 2024-02-26 |
| 188 | The Efficacy of Recto-intercostal Fascial Plane Block and Pecto-intercostal Fascial Plane Block for Postoperative Analgesia Management After Cardiac Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In cardiac surgeries performed with median sternotomy, mediastinal and thoracic tube placement sites are outside the area of effect of parasternal blocks, and sometimes the sternotomy incision extends below the T6 dermatome. Recto intercostal fascial plane block (RIFPB) has been defined as a complementary block for analgesia of this region. This study aims to evaluate the effectiveness of the combination of ultrasound-guided recto-intercostal fascial plane block and pectointercostal fascial block for postoperative analgesia management after open heart surgery (coronary artery bypass) with median sternotomy. |
BAHADIR CIFTCI; | 2024-02-25 |
| 189 | Ultrasound-guided Bilateral Two Levels Serratus Anterior Plane Block in Pediatric Cardiac Surgery With Median Sternotomy : A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The serratus anterior plane block (SAPB) is an anterolateral thoracic wall block that was described in 2013 by Blanco et al. who presented it as an alternative to other regional anesthetic techniques. It has been described in adults as an adjunct to general anesthesia or as a primary anesthetic technique for breast surgery, … |
MAI MADKOUR; | 2024-02-20 |
| 190 | Stepped-Care Online Parent Support Following Congenital Heart Disease: A Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate a virtual mental health parenting stepped-care intervention (I-InTERACT-North) to determine if the program works to improve positive parenting skills and child behaviour among families with children born with Congenital Heart Disease (CHD). Recruitment will target children ages 3-9 years old from SickKids. We will also evaluate the acceptability and feasibility of the program among children and families to inform future delivery and multi-site trials. Results will evaluate whether I-InTERACT-North can improve parenting and child behaviour in these families and inform future best clinical practices for this population. |
TRICIA WILLIAMS; | 2024-02-15 |
| 191 | Cross-Talk Between Arterial Calcifications PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Potential Cross-Talk Between Arterial Calcifications Background Vascular calcification is a key component of atherosclerosis. This study investigates the potential correlations between aortic and coronary calcifications detected via abdominal CT, considering age-related variations, to explore the possibility of cross-talk. Method A total of 921 patients (n=921) \[male: 508 (55%), female: 413 (44.7%)\] were divided into three age groups: 40-49, 50-69, and 70-90 years. Non-contrast abdominal CT scans were evaluated for calcifications in the coronary arteries, thoracic aorta, abdominal aorta (AA(1): suprarenal, AA(2): renal, AA(3): infrarenal), iliac arteries, and femoral artery. Aortic branches were categorized by calcification levels: none, \<25%, 25-50%, ≥50% |
ŞAHBENDER KOÇ; | 2024-02-02 |
| 192 | Effect of Maternal Voice and Music Therapy on Pain and Physiological Parameters During The Suction Procedure in Intubated Children: Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Children on mechanical ventilation are given painful stimuli an average of 10-14 times a day, and endotracheal aspiration is one of the procedures that causes the most pain in these children. Effective pain control not only improves the quality of life of children undergoing cardiothoracic surgery, but can also improve clinical outcome. If pain is not alleviated or eliminated with effective interventions during this period, it may cause neurological and behavioral disorders in the future. Excessive and long-term pain, especially as a result of applied interventions, … |
FULYA KOS; | 2024-02-02 |
| 193 | To Develop A Walking Exercise Program for Non-ambulatory Stroke Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test a gait (walking) training program in non-ambulatory (unable to walk) chronic stroke survivors. The main question it aims to answer is: • Will gait training improve the cardiovascular system in non-ambulatory chronic stroke survivors better than a sitting leg cycling exercise? Participants will walk on a treadmill with a partial body-weight support system and the gait training device. Researchers will compare with a leg-cycling exercise to see if there are significant differences in resting heart rate, systolic blood pressure (SBP), and A1c levels in the blood. |
WEN LIU; | 2024-02-02 |
| 194 | Clinical Comparison of Low-dose Rosuvastatin Plus Ezetimibe Combination Therapy and High-dose Rosuvastatin Monotherapy in Patients with Minimal to Intermediate Coronary Artery Disease Without Percutaneous Coronary Intervention : A Prospective, Multicenter, Randomized, Open-label Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: \[Purpose of the Clinical Study\]:The purpose of this study is to conduct a clinical comparison of low-dose rosuvastatin plus ezetimibe combination therapy and high-dose rosuvastatin monotherapy in patients with minimal to intermediate coronary artery disease without percutaneous coronary intervention to confirm non-inferiority in the reduction of key cardiovascular events. \[Hypothesis\]:In patients who have not undergone percutaneous coronary intervention for minimal to moderate coronary artery disease, low-dose rosuvastatin and ezetimibe combination therapy are non-inferior in terms of reducing major cardiovascular events compared to high-dose rosuvastatin monotherapy. |
SUNG-HO HER; | 2024-02-01 |
| 195 | Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II (STLEUISII) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: AliveCor (www.alivecor.com) has developed several electrocardiogram (ECG) devices that interface with iOS and Android smartphones and tablets via various Kardia apps. The current Kardia family of devices can measure single lead and six limb-lead ECGs, depending on the device. KardiaMobile, KardiaMobile 6L, and KardiaMobile Card have FDA clearance for ECG rhythm recording. A modified single-lead Kardia smartphone 12-lead ECG was previously validated in the multicenter ST LEUIS study for the diagnosis of ST-Segment Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI). Recently, … |
GREGORY BARSNESS; | 2024-02-01 |
| 196 | Clinical Evidence Based and TCM Phenotype Group Study of Zhilong Huoxue Tongyu Capsule in The Treatment of Stable Angina Pectoris of Coronary Heart Disease (Qi Deficiency and Blood Stasis Syndrome) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study intends to prove the clinical effect of Zhidong Huoxue Tongyu capsule in the treatment of stable angina pectoris with qi deficiency and blood stasis syndrome from the perspective of TCM syndrome differentiation and treatment. To detect metabolites in serum, urine and feces of patients with stable angina pectoris syndrome of qi deficiency and blood stasis by LC-MS metabolomics technology. Compared with normal control group, differential metabolites were found to provide molecular basis for the diagnosis of the disease. Metabolomics technology based on LC-MS was used to analyze the metabolites in serum, … |
JIANG HANMEI; | 2024-02-01 |
| 197 | Regulation of Cardiac Function After TAVR in Patients With Severe Aortic Stenosis Combined With Cardiac Insufficiency: A Prospective, Single-center, Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with severe aortic stenosis combined with severe heart failure often miss the opportunity for surgery, and the prognosis is poor with drug therapy alone.In recent years, the emergence of transcatheter aortic valve replacement (TAVR) has brought new hope for these patients, and since its birth in 2002, TAVR has been widely used internationally, and its safety and efficacy have been confirmed by several large, prospective, randomized controlled studies. Levosimendan is a new type of positive inotropic drug. It not only enhances myocardial contractile force through calcium sensitization, … |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2024-02-01 |
| 198 | The Effect of Fetal Heart Sound Played By Parents Diagnosed with Risky Pregnancy on Attachment and Anxiety PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The research was designed as a randomized controlled experimental type to determine the effect of fetal heart sound played to parents diagnosed with risky pregnancies on attachment and anxiety. With the results obtained from this study, … |
HILAL DINCER; | 2024-02-01 |
| 199 | Evaluation of The Effectiveness of Modern Technologies in Psychologically-enhanced Rehabilitation in Patients With Cardiovascular Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study evaluates how various therapeutic approaches perform in addressing depression, anxiety symptoms, and stress levels among patients in the second stage of cardiac rehabilitation. This study aims to evaluate the influence of the used therapeutic approaches on psychological outcomes and to compare the effectiveness of these therapies. |
ADAM WRZECIONO; | 2024-02-01 |
| 200 | Web-based Nursing Intervention to Promote Physical Activity Among Older Adults With Coronary Heart Disease: Protocol for A Mixed Method Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop and evaluate a web-based nursing intervention aimed at increasing physical activity in people aged 65 years and older with coronary heart disease. This study aims to answer the following questions: 1. What are the needs of older adults living with coronary heart disease in terms of a web-based nursing intervention to help them increase their level of physical activity? 2. What is the acceptability (content, structure, usefulness) and feasibility (recruitment, retention, adherence, … |
CENTRE HOSPITALIER DE L’UNIVERSITÉ DE MONTRÉAL CHUM | 2024-02-01 |
| 201 | A 6-Month, Double-Blind, Placebo-Controlled Pilot Study of High-Dose Resveratrol in Patients With Stable Ischemic Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This 6-month, randomized, double-blind, placebo-controlled pilot study investigates whether high-dose resveratrol (500 mg/day), when added to standard therapy, can improve endothelial function and reduce inflammation in patients with stable ischemic heart disease. While preclinical data and small trials have shown promising effects on vascular health and inflammation, larger studies have lacked consistent results. This study aims to provide more robust clinical evidence by assessing flow-mediated dilation (FMD) and high-sensitivity C-reactive protein (hs-CRP) as primary outcomes in a well-defined patient group. |
S LAB SOLOWAYS | 2024-02-01 |
| 202 | A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Study The Effect of G1899 (Korean Red Ginseng Extract Powder) on Blood Flow in Healthy Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this clinical trial are to 1) determine the effect of the TP compared to placebo on blood flow and platelet aggregation, 2) to determine the effect of the TP on cardiovascular health compared to a placebo and 3) to assess the safety and tolerability of the TP in healthy adults. |
AMIR H.S. RAFIE; | 2024-01-31 |
| 203 | Clinical Validation of A Novel Ultrasound Probe (RescueDoppler) During Physiological Perturbations and Initiation Of- and Weaning from Cardiopulmonary Bypass in Adult, Cardiac Surgery Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate a new device called RescueDoppler (RD), which measures continuous blood flow in the common carotid artery. The device is handsfree and operator- independent. The research will involve adult participants who are undergoing cardiac surgery at St. Olavs Hospital in Trondheim, Norway. The aim of the first part of the study is to evaluate the RescueDoppler system in comparison to conventional Doppler ultrasound, which is commonly used to assess blood flow in carotid artery. The researchers will measure blood flow in the left common carotid artery in three different reversible situations: – … |
ST OLAVS HOSPITAL | 2024-01-28 |
| 204 | Feasibility of A Multifaceted Intervention to Mitigate The Cardiovascular Adverse Effects of Air Pollution: The COATED-AIR Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main goal of this clinical trial is to evaluate the feasibility of conducting a large-scale clinical trial testing a program containing several aspects for reducing the effects of air pollution on cardiovascular health (which is named the hybrid program hereafter) in adult patients (18 years or older) with atherosclerotic cardiovascular disease. Furthermore, we seek to answer how much patients adhere to and are satisfied with implementing the hybrid program, and what problems executing this program will bring for patients. |
PARHAM SADEGHIPOUR; | 2024-01-28 |
| 205 | Cardiovascular Risk Assessment For Kidney Transplantation – Utility of Computed Tomography Coronary Angiography in The Assessment of Patients Awaiting Kidney Transplantation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause of death in patients following transplantation. Current strategies to assess patient’s cardiovascular risk prior to kidney transplantation do not identify those at highest risk and do not improve outcomes. This study will use a heart scan known as computed tomography coronary angiography (CTCA) to see whether this scan can identify patients at highest risk of future cardiovascular disease prior to transplantation. Studies have shown it is able to do this in patients with normal kidney function. The aim of this study is to develop CTCA as an effective tool to risk stratify patients prior to kidney transplantation. |
NEERAJ DHAUN; | 2024-01-24 |
| 206 | Targeting Trimethylamine N-Oxide for Cardiovascular Health In Liver Transplant Recipients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite medical and surgical advances, long-term survival in liver transplant (LT) recipients is compromised by an increased risk of cardiovascular disease (CVD) after transplant, the mechanisms of which are still not fully understood. TMAO is an attractive therapeutic target to improve vascular health and diastolic function toward preventing CVD in LT patients. Therefore, the purpose of this study is to better understand the role of TMAO in cardiovascular dysfunction patients with chronic kidney disease. |
DANIELLE KIRKMAN; | 2024-01-18 |
| 207 | Impact Du Bilan Et De La Prise En Charge Des Comorbidités En Médecine Interne Sur Le Risque Cardiovasculaire PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of assessing and managing cardiovascular risk is to avoid, limit or delay cardiovascular morbidity and mortality. Planned internal medicine hospitalization is developed around the management of cardiovascular risk in patients at high cardiovascular risk, whether in primary prevention or secondary prevention. During planned hospitalization, patients benefit from comprehensive, personalized and adapted care for their comorbidities and their CVRF (cardiovascular risk factors). This study will make it possible to evaluate this overall course of multidisciplinary management of comorbidities of patients at high cardiovascular risk. |
CAMILLE ROUBILLE; | 2024-01-15 |
| 208 | Multiparametric Cardiac Positron Emission Tomography for Cardiac Allograft Vasculopathy Surveillance After Heart Transplantation PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiac allograft vasculopathy (CAV) is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. Surveillance for CAV is vital; however an ideal approach has not been established. The goal of this study is to assess whether noninvasive positron emission tomography (PET) based surveillance is non-inferior to invasive coronary angiography (ICA) surveillance. |
SHARON CHIH; | 2024-01-08 |
| 209 | Impact of A Cardiac Rehabilitation Program in Patients With Cardiovascular Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This protocol study aims to evaluate the effectiveness of a cardiac rehabilitation intervention program in patients with cardiovascular diseases to improve both anthropometric and biochemical data, as well as other variables related to cardiovascular disorders (cardiorespiratory fitness, muscle strength, …), and emotional aspects (anxiety, depression). Additionally, this study aims to evaluate the effectiveness of the cardiac rehabilitation program in improving body composition (waist circumference and body fat percentage), blood pressure and health-related quality of life. Objectives: i) To assess the functional capacity of patients with a recent cardiovascular event (acute coronary syndrome, onset heart failure, … |
SUSANA PRIEGO-JIMÉNEZ; | 2024-01-08 |
| 210 | Absence of Standard Modifiable Risk Factors Among 5000 Middle Eastern Patients With Atherosclerotic Cardiovascular Disease: Clinical Profiles and Prevalence of Other Risk Factors and Comorbidities PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: A growing number of patients develop atherosclerotic cardiovascular disease (ASCVD) despite the absence of standard modifiable risk factors (SMuRF-less). There is scarcity of studies that address this issue in the Middle Eastern population. |
JORDAN COLLABORATING CARDIOLOGY GROUP | 2024-01-01 |
| 211 | Risk Factors and Novel Biomarkers Associated With In-stent Restenosis After Percutaneous Coronary Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To study the relation between ISR and neutrophil-to-lymphocyte ratio (NLR), novel biomarkers (high-sensitivity CRP (hs-CRP), bone morphogenetic protein-2 (BMP-2) and other risk factors (age, sex, smoking, hypertension, diabetes, obesity, chronic kidney disease (CKD; creatinine clearance). |
ELHUSSEIN AHMED MOHAMED; | 2024-01-01 |
| 212 | Polyamine Treatment in Elderly Patients with Coronary Artery Disease – A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study. |
HENRIK WIGGERS; | 2024-01-01 |
| 213 | Relation of Laboratory Indices to Left Ventricular Thrombus Formation in Patients With Acute Anterior ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention or Thrombolytic Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: • to find the relationship between the different hematological indices including platelet indices, and blood cell ratios, to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary intervention (PPCI) , or thrombolytic therapy . |
AL ZAHRAA SAYED MAHMOUD MOHAMED; | 2024-01-01 |
| 214 | Effects of Rehabilitation Programme on Respiratory Function in Patients With Acquired and Intervened Congenital Heart Disease: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart defects (CHDs) are heart malformations that occur before birth, and they represent one of the leading causes of neonatal morbidity and mortality. they occur in approximately 1% of newborns and are associated with high morbidity and mortality rates. The etiology of these cardiac anomalies is mostly unknown. around 70-80% of cases are generated by the involvement of multiple affected genes combined with an environmental trigger that, when acting on a susceptible individual, promotes the expression of the damaged genome. maternal diseases during pregnancy or exposure to teratogenic substances are also implicated in the etiology. |
JUAN LUIS SANCHEZ GONZALEZ; | 2024-01-01 |
| 215 | Concealed Myocardial Abnormalities By Cardiac Magnetic Resonance Imaging in Idiopathic Ventricular Arrhythmias PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Idiopathic Ventricular arrhythmia (VAs) refers to VAs that occur in the absence of clinically apparent structural heart disease. The outflow tracts (OTs) are the most common origin of idiopathic VAs and PVCs, accounting for approximately 10% of all patients referred for evaluation of VAs with the RVOT being the origin of about 70-80% of these arrhythmias. Studies have shown that increased PVC burden was associated with reduced LV function, a higher incidence of heart failure, and a higher risk of death. The diagnosis, … |
EMAN ABDALLAH HASABALLAH FARAG; | 2024-01-01 |
| 216 | Predictors of Aortic Root Dilatation in Tetralogy of Fallot Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: – To predict vulnerable patients for aortic root dilatation in TOF patients using CT as a reliable imaging modality, thus aiding early intervention, and identifying those who will require strict follow-up. – To assess the prevalence of TOF patients who developed aortic root dilatation, and those who were complicated with dissection, AR, and aneurysm, through collecting data from a large center (Aswan Heart Centre). – To investigate the relationship between age at repair and the diameter of aortic root. |
ABDELRAHMAN GAMAL AHMED RAMADAN; | 2024-01-01 |
| 217 | Early Feasibility Study of The Supira System in Patients Undergoing High-Risk Percutaneous Coronary Intervention (HRPCI) – The SUPPORT I Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to assess the feasibility and safety of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing HRPCI. The clinical data may be used to support subsequent regulatory applications and further evaluation of the Supira System. |
SUPIRA MEDICAL | 2024-01-01 |
| 218 | Emergency Resuscitative Endovascular Balloon Occlusion of The Aorta in Out of Hospital Cardiac Arrest PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the feasibility of performing pre-hospital resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to conventional Advanced Life Support (ALS) in patients suffering from non-traumatic out of hospital cardiac arrest (OHCA). As well as providing valuable insights into the technical feasibility of performing this procedure as part of a resuscitation attempt, the study will also document the beneficial physiological effects of REBOA in this group of patients. |
PAUL REES; | 2024-01-01 |
| 219 | Is Reducing Flow in Affected Branch Pulmonary Arteries in Patients With Partial Anomalous Pulmonary Venous Drainage Using A Percutaneous Approach Safe and Efficacious? – A Pilot Study Related Papers Related Patents Related Grants Related Experts View Highlight: Partial anomalous pulmonary venous drainage (PAPVD) occurs in around 1 in every 1000 people. Blood from part of the lung returns to the wrong side of the heart, causing the heart to stretch. This causes breathlessness and heart rhythm problems in later life. PAPVD can currently only be fixed by open heart surgery, and when the abnormality affects the right lung, even this can be impossible. This study is designed to examine whether a new keyhole procedure to limit blood flow through the affected lung segments can be safely used to reduce the impact of PAPVD on the heart, … |
THE LEEDS TEACHING HOSPITALS NHS TRUST | 2024-01-01 |
| 220 | IMPACT of Nebilet in Blood Pressure Control in Patients With HYpertension: An Observational, Longitudinal Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The HYIMPACT study (IMPACT of Nebilet® in Blood Pressure Control in Patients with Hypertension) is a multinational, multicenter, observational, prospective, longitudinal real-world evidence study designed to assess the effectiveness and safety of Nebilet® (nebivolol) in hypertensive patients. The study aims to evaluate changes in systolic and diastolic blood pressure from baseline to 12, 24, and 36 months, as well as treatment adherence, quality of life, prescription patterns, and cardiovascular outcomes. A total of approximately 5,000 hypertensive patients with or without cardiovascular comorbidities will be enrolled across seven Asian countries (Malaysia, Indonesia, the Philippines, Korea, Vietnam, Thailand, … |
A MENARINI ASIA PACIFIC HOLDINGS PTE | 2023-12-20 |
| 221 | Application of A Multimodal Large Language Model to Assist Diagnosis for Heart Failure With Preserved Ejection Fraction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will validate the effectiveness of a multimodal large language model to screen for heart failure with preserved ejection fraction (HFpEF), comparing it with the traditional clinical standardized assessment process. |
TANG YIDA; | 2023-12-20 |
| 222 | The Feasibility and Triability of A Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries/Procedures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop and evaluate a frailty-specific prehabilitation program for patients awaiting cardiac surgeries/procedures. The program aims to improve functional capacity, frailty level, cardiac-related physical functioning, health-related quality of life (HRQoL), psychological distress, major adverse cardiovascular and cerebral events (MACCE), hospital length of stay, and readmission rates. Cardiovascular disease is a leading cause of disability and morbidity globally, particularly in older adults. Frailty, a geriatric syndrome commonly seen in cardiac patients, complicates their perioperative care and leads to worse outcomes. Prehabilitation, which optimizes patients’ physiological and functional capacities before surgery, … |
POLLY WAI-CHI LI; | 2023-12-18 |
| 223 | A First-in-Human Feasibility Study to Evaluate The Safety (and Short Term Effectiveness) of The Autologous GrOwnValve Transcatheter Pulmonary Heart Valve [GECT] Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of this study is to investigate the clinical safety of a novel pediatric heart valve. |
UNIV.-PROF. DR. MED. FRANK EDELMANN; | 2023-12-18 |
| 224 | Effect of Educational Program on Parental Stress of Parents of Children With Congenital Heart Disease Undergoing Cardiac Surgery: Quasi Experimental Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital Heart disease accounts for about one third of the all congenital anomalies. In last decades’ huge advancements occurred in treatment and diagnosis. More and more surgeries are being done which causes stress in parents and affects their mental health. Some studies have reported that about one third of the parents of children with CHD remain in stress even after surgery is being done. The goal of this trial is to evaluate effect of educational intervention on mental health of parents of children with congenital heart disease undergoing cardiac surgery compared to the parents who get usual care and pamphlets of the same information. The investigators are including parents of children with CHD who are already diagnosed with CHD and are undergoing cardiac surgery. |
HAMAYUN KHAN; | 2023-12-15 |
| 225 | The Effect of Health Education Based on Health Belief Model and Text Messages Given to Firefighters on The Level of Knowledge, Awareness and Quality Of Life About Cardiovascular Disease Risk Factors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was planned to evaluate the effect of a health education program based on the health belief model and text messages on the level of knowledge, awareness and quality of life regarding cardiovascular disease risk factors in firefighters. A total of 160 firefighters, 84 in the intervention group and 76 in the control group, … |
ZEHRA KARTOĞLU; | 2023-12-04 |
| 226 | Study of The Effect of Eicosapentaenoic Acid (EPA) on Markers of Atherothrombosis in Patients With Type-2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigation of the efficacy and safety of an Eicosapentaenoic acid (EPA) supplement versus a placebo supplement on plasma triglyceride levels as well as inflammatory, thrombotic, endothelial and platelet activation markers, in patients with type-2 diabetes mellitus (DM-2). |
ALEXANDROS TSELEPIS; | 2023-12-01 |
| 227 | The Impact of Perioperative Neurovascular Coupling on Outcome in Infants With Congenital Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Infants with congenital heart disease (CHD) are at increased risk for delayed neurodevelopment. Multiple etiological explanations have been proposed, as there seems to be a multifactorial interplay of both prenatal and perioperative factors. The main goal of this research project is to focus on peri-operative physiological risk factors in infants with CHD which impair functional brain maturation or elicit brain injury, and subsequently creating a risk model and guidelines for standardized developmental follow-up in this population. PART 1: investigation of cerebral autoregulation and neurovascular coupling The homeostasis in cerebral blood supply regardless of perfusion pressure, … |
UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN | 2023-12-01 |
| 228 | The Effect of Nursing Approach Based on MELEIS Transition Theory on Cardiac Quality of Life and Adaptation to Disease in Patients With Acute Myocardial Infarction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The effect of nursing approach based on Meleis’s transition theory on cardiac quality of life and adaptation to disease in patients with acute myocardial infarction. This research was planned with the idea that the approach developed based on Meleis’s Transition Theory could facilitate the illness-health transition process in patients, increase their healthy behavioral gains, increase the quality of care, reduce rehospitalizations, reduce the mortality rate due to MI, and contribute to the nursing literature. |
SERDAR ZENGIN; | 2023-12-01 |
| 229 | Effect of Gliflozins on Heart Failure Due to Regurgitant Rheumatic Valve Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this trial is to detect impact of Gliflozin on patients with heart failure due to reurgitant rheumatic valve disease |
AHMED YOUSSEF DANDRAWY; | 2023-12-01 |
| 230 | A Randomized, Controlled Trial in Patients With Suspected Coronary Artery Disease Based on Acute or Chronic Atypical Angina Pectoris – EXTEND PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: CAD-Man Extend is the long-term follow-up (clinical, laboratory, and computed tomography (CT) imaging) of a single-center, randomized, controlled CAD-Man trial comparing a CT-first strategy with a direct- invasive coronary angiography (ICA) diagnostic and management strategy, in 329 patients clinically referred for ICA with atypical angina or chest pain. Overall goal: The extension of CAD-Man follow-up (clinical, laboratory, and CT imaging) to approximately 10 years will provide the opportunity to compare plaque burden with CT-guided management versus direct-ICA at long-term and other endpoints. |
MARC DEWEY; | 2023-12-01 |
| 231 | Assessment of Right Ventricular Function Among Children With Chronic Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Pediatric Chronic lung disease (CLD) is an abroad term that encompasses a heterogeneous group of different clinicopathological disorders that advance slowly over months or years. They can broadly be divided into two groups: those with a known cause and those without. Cystic fibrosis, broncho-pulmonary dysplasia or lung of prematurity, asthma, chronic gastro esophageal reflux/aspiration pneumonitis, and constrictive obliterative bronchiolitis, chronic infection, and hypersensitivity pneumonitis are all included in the first group. The second group is subdivided into primary pulmonary diseases (idiopathic interstitial pneumonia, persistent tachypnea of infancy associated with neuroendocrine cell hyperplasia, pulmonary lymphatic and vascular disorders, … |
ASSIUT UNIVERSITY | 2023-12-01 |
| 232 | Effect of Milrinone on The Right Ventricular Strain in Cardiac Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to analyze the changes in right ventricular strain before and after milrinone administration in order to find out whether milrinone improves RV systolic performance in patients undergoing cardiac surgery. |
TAE-YOP KIM; | 2023-12-01 |
| 233 | The Influence of Cardiovascular Risk Factors on Electrocardiographically and Hemodynamics Responses to Treadmill Exercise Test in Asymptomatically Subjects: A Clinical Perspective (ERGO-RISC) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational cross-sectional study is to analyze the effect of cardiovascular risk factors in healthy and asymptomatic populations. The main questions it aims to answer are: – Does the combination of the presence of different risk factors increase the risk for abnormalities appearing on electrocardiograms, such as ischemia, arrhythmia, and hemodynamics effects during and at the peak of effort of treadmill exercise test? – What are the main differences observed in the recovery period? Participants will answer an anamnesis of risk factors such as sex, race, age, familiar history of coronary artery disease, overweight or obesity, smoking, … |
PEDRO GABRIEL SENGER BRAGA; | 2023-11-30 |
| 234 | Magnetocardiography As A Noninvasive Diagnostic Strategy for Suspected Myocardial Ischemia With The Absence of Obstructive Coronary Artery Disease As Confirmed By Thermodilution-Derived CFR PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be an observational registry to investigate the ability of magnetocardiography (MCG) in determining the presence of myocardial ischemia with the absence of obstructive coronary artery disease, by using an invasive reference standard coronary flow reserve (CFR) measured using thermodilution for diagnosis. Up to 200 participants in a 1:1 ratio of CMD positive to CMD negative will be enrolled. The device is a magnetocardiography (MCG) scanner named CardioFlux, which is paired with cloud processing software. A CardioFlux scan appointment shall last approximately 15 minutes in duration and include a patient questionnaire following the scan. |
ODAYME E QUESADA; | 2023-11-21 |
| 235 | A Phase 3, Randomised, Double-blind, Parallel-group, Event-driven, Cardiovascular Safety Study With BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity With Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, And/or at Least Two Weight-related Complications or Risk Factors for CVD PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults who are at least 18 years old and have a body mass index (BMI)bof 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related to their weight or risks of cardiovascular disease can participate. Participants must have previously tried to lose weight by changing their diet. The purpose of this study is to find out whether people with overweight or obesity who take a medicine called survodutide (BI 456906) are less or more likely to develop serious cardiovascular problems. It also aims to find out whether health parameters like blood pressure improve. Overweight and obesity are linked to cardiovascular disease. Survodutide is a medicine that is developed to help people with obesity or overweight to lose weight. Participants are divided into 3 groups of almost equal size. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under the skin once a week. All participants also receive counselling on diet and physical activity. Participants are in the study for up to 2 years and 3 months. During this time, it is planned that participants visit the study site up to 21 times and attend remote visits by video calls. During these visits, the doctors check participants’ cardiovascular and overall health. The results are compared between survodutide and placebo groups. The study staff also takes note of any unwanted effects. |
BOEHRINGER INGELHEIM | 2023-11-20 |
| 236 | The Effect of Kangaroo Care on Vital Signs of Infants After Cardiac Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to investigate the effects of kangaroo care on the vital signs of infants undergoing cardiac surgery. Hypothesis 1 (H1): Oxygen saturation levels of babies who are given kangaroo care are higher than babies who are not given kangaroo care. Hypothesis 2 (H2): The peak heart rate of infants who receive kangaroo care is lower than infants who do not receive kangaroo care. Hypothesis 3 (H3): The respiratory rate of infants who receive kangaroo care is lower than infants who do not receive kangaroo care. Hypothesis 4 (H4): The arterial blood pressure of infants who receive kangaroo care is lower than infants who do not receive kangaroo care. Hypothesis 5 (H5): The pain score of infants who received kangaroo care is lower than infants who did not receive kangaroo care. |
DILARA CENGIZLI; | 2023-11-19 |
| 237 | Clinical Presentation, Coronary Angiographic Findings and Extent of Atherosclerotic Disease in Patients With Acute Coronary Syndrome Associated With Cocaine Use PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cocaine use has increased in our country in recent decades. It is associated with cardiovascular events and early atherosclerotic disease. Acute coronary syndrome (ACS) is one of its most frequent and serious manifestations. There is a lack of scientific information on ACS associated with acute and chronic cocaine use in Argentina. This study aims to describe the socioeconomic, clinical, and coronary angiographic characteristics, as well as the extent of atherosclerotic disease in patients with ACS associated with cocaine use, and to compare them with ACS not associated with cocaine use. Methods: We propose an observational, analytical, single-center, two-phase study, … |
MAXIMILIANO DE ABREU; | 2023-11-17 |
| 238 | The Outcome of Interventional Cardiac Catheterization In Pediatric Cardiology Unit, Assiut University Heart Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Describe demographic and clinical data of infant and pediatric with cardiac catheterization who admitted to cardiology unit of Assiut university children hospital Asses outcome of cardiac catheterization in pediatric and infant at AUCH |
AYA ZIDAN SAYED GOMAA; | 2023-11-17 |
| 239 | Prevalence of Systemic Inflammation in Patients With Atherosclerotic Cardiovascular Disease and Heart Failure PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will collect medical and background information from participants with diseases that affect the heart and blood vessels (cardiovascular disease). Participants will continue their normal care and will not get any treatment other than those the study doctor has prescribed. |
NOVO NORDISK | 2023-11-15 |
| 240 | ChAracterization of Patients and Treatment OUtcomes in Severe Tricuspid Regurgitation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to characterize the population of patients qualified for transcatheter tricuspid valve interventions (TTVI). It is expected to: * Describe the profile of patients qualified for TTVI * Establish the most common causes for disqualification from TTVI * Evaluate the immediate and long-term efficacy of TTVI * Evaluate TTVI safety Participants will undergo a standard qualification procedure for TTVI and then will be subject to a follow-up consisting of clinical examination, echocardiography and laboratory testing. |
MARIUSZ TOMANIAK; | 2023-11-14 |
| 241 | Digital Monitoring for Patients Post Coronary Interventions to Reduce Risk for Recurrent Adverse Cardiovascular Events PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to support patients immediately after PCI by implementing a telemonitoring program. Eligible patients have coronary heart disease and undergo PCI. The intervention group receives remote monitoring and text-based follow-up, with established health goals and education on using the telemonitoring application, along with necessary devices. The control group gets standard care. Outcomes measured include blood pressure, LDL levels, patient satisfaction, revascularization, and mortality. The study findings will enhance patient care after PCI and contribute evidence for widespread telemonitoring implementation in healthcare systems, aiding medical therapy and lifestyle modifications. |
UNIVERSITY OF CALIFORNIA DAVIS | 2023-11-10 |
| 242 | Evaluation The Efficacy and Safety of An Interventional Left Ventricular Assist System for Hemodynamic Support in Patients With Cardiogenic Shock: A Prospective, Multicenter, Single-group Target Value Study of Sustained PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Imported Impella The price is relatively expensive and difficult for ordinary patients to afford. In order to better meet the growing clinical needs in China, Anhui Tongling Bionic Technology Co., Ltd. has developed an interventional left ventricular assist system. The test device was tested in preclinical animals It has shown good effectiveness and safety. Through the implementation of this clinical trial, the interventional left ventricular assist system The safety and effectiveness of the system for hemodynamic support in patients with cardiogenic shock have led to further development of this product in the country. |
LIANG-WAN CHEN; | 2023-11-08 |
| 243 | Leveraging Wearable Technologies for Arrhythmia Detection in Children – The PAW (Pediatric Apple Watch) Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Specific Aim #1 – To determine the accuracy of Apple Watch ECG tracings heart rate in children. Specific Aim #2 – To determine if extended monitoring with the Apple Watch can identify arrhythmia events that were not detected by short term clinical monitoring. |
SCOTT CERESNAK; | 2023-11-01 |
| 244 | The Effect of Neural Therapy on Heart Rate Recovery, Cardiac Parameters and Pain in Fibromyalgia: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Autonomic dysfunction has been observed in patients with fibromyalgia and is associated with symptoms and arrhythmia development in such patients.The investigators can analyze dysautonomia using heart rate recovery (HRR). Studies have reported that impaired HRR improves after exercise in fibromyalgia patients. Although previous theories have suggested that neural therapy benefits fibromyalgia patients by regulating autonomic dysfunction, there are no studies in the literature reporting that neural therapy improves autonomic dysfunction. Aims: The purpose of the present study was to compare whether neural therapy + exercise therapy provided more improvement in impaired HRR, cardiac parameters, … |
SEBAHAT TEKELI SENGUL; | 2023-11-01 |
| 245 | Is Sacubitril-valsartan Superior to Dapagliflozin in Improving Myocardial Function and Performance in Patients With Ischemic Cardiomyopathy Undergoing Coronary Artery Bypass Grafting Post-operatively in The Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess whether sacubitril-valsartan is more effective than dapagliflozin in improving function, myocardial performance in patients undergoing CABG operation or not |
AMR GABER; | 2023-11-01 |
| 246 | Effectiveness of A+AVD Vs ABVD Regimens in Advanced Classical Hodgkin’s Lymphoma Patients: A Retrospective, Multicentre, Medical Chart Review Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of this study conducted in Brazil is to understand if there is a difference in the length of time that Classical Hodgkin’s Lymphoma (cHL) does not grow or spread further (also called progression free survival or PFS), and in the length of time that participants live with cHL if they are treated with Brentuximab Vedotin in combination with chemotherapy (A+AVD) or chemotherapy alone (ABVD). A+AVD includes Brentuximab Vedotin + Doxorubicin + Vinblastine + Dacarbazine; ABVD includes Doxorubicin + Bleomycin + Vinblastine + Dacarbazine. The study will be conducted by reviewing and collecting already existing medical records. |
MARCO AURÉLIO SALVINO; | 2023-10-31 |
| 247 | Effects of Relaxation Breathing Exercises on Cardiovascular Parameters Among Hypertensive Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study will be to compare the effects of Relaxation Breathing Exercises on Cardiovascular Parameters among Hypertensive patients. This study will be a Randomized Clinical trial. Data will be collected from Allied and DHQ hospital Faisalabad. One group will receive Breathing Exercises and other group will receive usual care. All subjects will receive a total of three treatment sessions per week over the period of 12 weeks. Outcome will be measured at baseline, 6th and 12th week of treatment. |
DANISH HASSAN; | 2023-10-30 |
| 248 | The Effect of Slow Breathing Exercise Applied to Patients After Primary Percutaneous Coronary Intervention on Pulse, Blood Pressure and Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was designed as a randomized controlled experimental type in order to determine the effect of slow breathing exercise applied after the procedure on heart rate, blood pressure and quality of life in patients who underwent Primary Percutaneous Coronary Intervention (PCI) I after the diagnosis of ST Elevation Myocardial Infarction (STEMI). Patients who underwent primary PCI due to STEMI in a Training and Research Hospital in Istanbul will constitute the study population. A sample will be formed with a total of 80 patients, 40 experimental and 40 control groups, … |
MELIKE ÇELIK; | 2023-10-23 |
| 249 | The Prospective, Multi-center, Single-arm Clinical Evaluation Trial of The CorVad Percutaneous Ventricular Assist System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the safety and effectiveness of the CorVad Percutaneous Ventricular Assist System for short-term ventricular support during high-risk percutaneous coronary intervention (HRPCI) in non-emergent, hemodynamically stable coronary artery disease patients via a prospective, multicenter, single-arm clinical trial. |
KE FEI DOU; | 2023-10-19 |
| 250 | Invasive Hemodynamic Control Cohort for The Mayo Clinic Adult Congenital Heart Disease (MACHD) Registry PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research study is being done to provide comparative data to the Mayo Clinic Adult Congenital Heart Disease Registry. |
ALEXANDER C. EGBE; | 2023-10-16 |
| 251 | Effects of Mindfulness-based Interventions on Psychophysiological Recovery and Physical Functioning in Patients After Coronary Heart Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to explore the effect of mindfulness on the physical and mental recovery and physical function of patients after coronary heart surgery. Methods: Convenience sampling was adopted, and patients in the cardiology ward of a northern medical center were selected as the research subjects. Eligible subjects were assigned to the experimental group (mindfulness treatment) and the routine care group. The subjects were tested on the day before surgery and on the seventh day after intervention. Physical and mental recovery (awareness of inner feelings, anxiety, depression, sleep quality, pain) and physical function (vital capacity, cardiorespiratory endurance, … |
MACKAY MEMORIAL HOSPITAL | 2023-10-15 |
| 252 | Experimental Validation of The Long-term Accuracy of Blood Pressure Measurement Using A Smartwatch PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to perform an experimental validation of the long-term accuracy of blood pressure measurement using the Samsung Galaxy Smartwatch |
JAKUB RAFL; | 2023-10-13 |
| 253 | Phase 3 Randomized, Placebo-Controlled Clinical Study to Evaluate The Efficacy and Safety of MK-0616 in Reducing Major Adverse Cardiovascular Events in Participants at High Cardiovascular Risk PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 3, randomized, placebo-controlled study of the efficacy and safety of enlicitide decanoate, an oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, in participants with high cardiovascular risk. The primary objective is to evaluate the efficacy of enlicitide decanoate compared with placebo in increasing the time to the first occurrence of major adverse cardiovascular events (MACE) including coronary heart disease (CHD) death, ischemic stroke, myocardial infarction (MI), acute limb ischemia or major amputation, or urgent arterial revascularization. |
MERCK SHARP & DOHME | 2023-10-09 |
| 254 | The Effect of Modified Supine Position on Urinary Elimination After Percutaneous Coronary Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Urinary retention is also a frequent complication after percutaneous coronary intervention applied via the femoral artery. The inability to manage this situation effectively leads to serious complications in the long term, prolonging the length of hospital stay and increasing the cost, as well as impairing the participants’s comfort. In the investigators’s country, … |
ESRA KARAGOZ; | 2023-10-09 |
| 255 | A Longitudinal Open-Label Multi-center Single-Arm Phase I/IIa Study to Evaluate The Safety and Preventive Effect on Cardiovascular Events of Human Allogenic Bone-Marrow-Derived Mesenchymal Stromal Cell Product, StromaForte, in Study Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this phase I/II clinical trial is to evaluate the safety and preventive effect of intravenous infusion of human allogeneic bone-marrow-derived mesenchymal stromal cell product StromaForte in study participants. The main questions it aims to answer are: To assess the safety and tolerability after 28 days of injection by reporting the number of adverse events assessed by Common Terminology Criteria For Adverse Events (CTCAE) To evaluate the effects of Mesenchymal stem cells on Prevention of Cardiovascular Events by following the reported incidence of cardiovascular events amongst study participants up to five year post-injection Participants will receive 100 x 106 allogeneic bone marrow (BM)-derived Mesenchymal Stromal Cell (MSC) formulated in sodium chloride supplemented with human serum albumin to be given via slow intravenous infusion 100 million cells in approximately 30 min |
CELLCOLABS CLINICAL | 2023-10-07 |
| 256 | Hyperpolarized 129-Xenon MRI in Fibrosing Interstitial Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to investigate the potential of non-invasive imaging to identify and monitor the earliest signs and physiological effects of pulmonary fibrosis and resulting cardiac dysfunction in patients with fibrosing interstitial lung disease. Second, to evaluate baseline risk factors the progression and therapeutic responses to anti-fibrotic drugs. |
ELISABETH BENDSTRUP; | 2023-10-05 |
| 257 | A Non-interventional Study to Assess The Impact of Clinical Decision Support Systems Included in Electronic Health Records on Compliance With Guidelines PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A non–interventional study to assess the impact of clinical decision support systems included in electronic health records on compliance with guidelines, including routing of patients with CHF, follow-up care, prescription and dose titration of medicinal products. |
SERGEY NIKOLAEVICH TERESCHENKO; | 2023-10-01 |
| 258 | Safety and Efficacy of The GUIDEX® Versus Launcher™ Guiding Catheter in Adults’ Patients With Coronary Artery Disease (CAD) Requiring Percutaneous Coronary Intervention (PCI): A Non-inferiority and Randomized, Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare two guiding catheters in patients with coronary artery disease during a percutaneous coronary intervention between Guidex® Guiding catheter (DEMAX) and Launcher™ coronary guide catheters (Medtronic). The main question[s] it aims to answer are: – Aren’t the safety of medical devices inferior to each other? – Aren’t the efficacyof medical devices inferior to each other? Participants will be randomized (1:1) and have a percutaneous coronary interventionwith one of the two guiding catheters. |
CLEMENT SERVOZ; | 2023-10-01 |
| 259 | Prevalance of Cardiovascular Complications in Children With COVID 19 in Assuit University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Abstract: In December 2019, coronavirus disease 2019 (COVID-19) was first described in Wuhan, China, in patients complaining of flulike symptoms.1 The virus was isolated and identified as a … |
OMAR ATIF ABD ELHALEEM; | 2023-10-01 |
| 260 | Angiotensin Converting Enzyme Rs (1799752) Gene Polymorphism and Development of In-Stent Restenosis in Patients With Stable Coronary Artery Diseases in Sohag Hospital University PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: One of the most common medical approaches to the treatment of coronary artery disease (CAD) is the percutaneous coronary intervention (PCI) which became frequent due to high efficiency and safety of this procedure. Modern-day advances in pharmacotherapy and the device innovations over the last thirty years enhanced the benign outcomes of patients with unstable or multivessel CAD, and multiple co-morbidities, … |
ZAINAB MAHMOUD KADRY; | 2023-10-01 |
| 261 | Obesity Phenotypes and Its Relation to Cardiovascular Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the association between obesity phenotypes with cardiovascular diseases. – Primary Outcomes: 1- To examine the association between different obesity phenotypes and cardiovascular diseases.by using echocardiography, lipid profile – Secondary Outcomes: 1. frequency of obesity phenotypes on our locality 2. Correlation between each type of obesity phenotypes and other metabolic disturbances (e.g. DM, dyslipidemia, NASH) 3. Correlation between epcardial fat, carotid intimal thickness and different obesity phenotypes. |
ASMAA KHALED SAYED; | 2023-10-01 |
| 262 | Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This multicenter clustered randomized prospective study will be managed by the American College of Radiology Center for Research and Innovation (ACR CRI). The research team aims to test the efficacy of a patient-centered educational intervention based on coronary artery calcification (CAC) information in cardiovascular risk factor modification of a cohort of patients enrolled in lung cancer screening (LCS) programs across the country. |
AMERICAN COLLEGE OF RADIOLOGY | 2023-09-30 |
| 263 | Determining The Effect of Care Package Implementation in Preventing Delirium in Patients Undergoing Coronary Artery Bypass Graft Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research investigates the effectiveness of a care package used in the care of patients undergoing coronary artery bypass graft (CABG) surgery in preventing postoperative delirium. CABG surgery is a common procedure used to increase blood flow to the heart and is typically applied in patients with severe cardiac diseases. However, this procedure can increase the risk of postoperative delirium, especially among elderly and critically ill patients. In this study, the goal is to reduce this risk by implementing a care package. The care package includes optimal pain management, sleep regulation, mobilization, ensuring patient orientation, … |
İSLAM ELAGÖZ; | 2023-09-30 |
| 264 | The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: End-stage heart failure (HF) is a progressive illness with a mortality rate similar to most advanced cancers.Roughly 5% of patients with HF have end-stage disease that is refractory to medical therapy (stage D heart failure). When patients reach this point in their disease, the only treatments known to prolong life are cardiac transplantation or left ventricular assist devices. In patients who do not qualify for these options, or elect a palliative approach, inotropes are frequently used to improve hemodynamics through an increase in cardiac output and reduction in filling pressures. While inotropes provide profound symptomatic relief, … |
AZITA TALASAZ; | 2023-09-30 |
| 265 | Perception of Cardiovascular Risk: Description of The Phenomenon in Primary Prevention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to describe the association between the perception of cardiovascular (CV) risk and the actual CV risk and, secondarily, to detect the actual CV risk to assess the prevalence of clinical risk factors, determined by means of appropriate instruments. |
NICCOLÒ SIMONELLI; | 2023-09-29 |
| 266 | Hyperpolarized MRSI in Ischemic Heart Disease: Metabolic Profiling of The Myocardium PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the potential of using hyperpolarized [1-13C]-pyruvate magnetic resonance imaging (MRI) to assess metabolic alterations in patients with ischemic heart disease (IHD). Altered myocardial metabolism is recognized as a crucial factor in heart failure and IHD, and modulating cardiac metabolism offers a new approach to treatment. However, current diagnostic modalities use ionizing radiation and have shown limited prognostic value. Hyperpolarization through dynamic nuclear polarization (DNP) enables highly sensitive in vivo detection of metabolic processes. Hyperpolarized [1-13C]-pyruvate allows visualization of glycolysis-related metabolism, providing insights into the breakdown of glucose and its derivatives. By using this technique, … |
HENRIK WIGGERS; | 2023-09-26 |
| 267 | Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As compared to the general population, those living with a spinal cord injury (SCI) are at a greater risk of cardiovascular (CV) diseases.The investigators know that regular exercise can help lessen the risk of CV diseases. However, those with higher level SCI have a limited ability to exercise due to their loss of function. Heat therapy has been shown to promote significant health benefits in populations with health challenges and has demonstrated a mild exercise like response. The investigators aim to extend these findings and develop a practical passive heat therapy program appropriate for safe home use. |
JAMES LASKIN; | 2023-09-15 |
| 268 | Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing Vs Biventricular Pacing With A Left Ventricular Epicardial Lead in Patients With Heart Failure (HF) With Left Ventricular Ejection Fraction (LVEF)≤50% and With Either A Wide QRS Complex (>130 Ms) or With/Anticipated >40% Pacing Randomized Clinical Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g., lead dislodgement, infection) relative to standard of care biventricular pacing in patients with heart failure due to left ventricular systolic dysfunction (LVEF≤50%) and with either a wide QRS (≥130 ms) or with/anticipated \>40% pacing who are already receiving current standard heart failure pharmacological therapy. |
MIHAIL GABRIEL CHELU; | 2023-09-13 |
| 269 | Feasibility Study SA of The Supira System for HRPCI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective is to assess the feasibility and safety of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing high-risk percutaneous interventions (HRPCI). |
RODOLFO STAICO; | 2023-09-13 |
| 270 | Using Closed-Loop Artificial Pancreas Technology to Reduce Glycemic Variability and Subsequently Improve Cardiovascular Health in Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes. AP technology is a system of devices that closely mimics the glucose-regulating function of a healthy human pancreas. It includes an insulin pump and a continuous glucose monitor (CGM). In this study, the investigators will research whether improvements in blood glucose levels and blood glucose variability will in turn decrease biomarkers of inflammation and endothelial dysfunction while improving cardiovascular function. |
WILLIAM HORTON; | 2023-09-09 |
| 271 | A Pilot Study to Examine Feasibility of A Patient Directed Tool to Assess Heart Health Among Endometrial Cancer Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators are conducting this study to find out more about what heart health means to participants and how healthcare providers can best help to manage heart health. Participants will be asked to view an electronic tool designed to promote heart health awareness and help to manage heart health outside of the clinic. This study will provide important information to help investigators develop future programs that improve cancer patient’s heart health after they complete their treatment. |
KATHRYN E WEAVER; | 2023-09-07 |
| 272 | Cardiac Biomarkers for The Quantification of Myocardial Damage After Cardiac Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to clarify whether the perioperative release of the cardiac biomarkers troponin I, troponin T and CK-MB consistently correlate with visualizable myocardial damage, and to what extent these biomarkers are comparable by means of their kinetics and dynamics. Due to the uncertainty regarding the validity of cardiac biomarkers in the diagnosis of myocardial infarction, the answer to these questions could have a considerable influence on internationally valid guidelines and definitions. International studies, especially in the field of coronary surgery and coronary artery disease treatment refer to these definitions, in particular, … |
ULRICH SCHNEIDER; | 2023-09-05 |
| 273 | Effects of Electrical Nervous Stimulation Transcutaneous Analysis on Blood Pressure of Patients Hypertensive: Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Systemic arterial hypertension is a disease characterized by high blood pressure levels. It has a high prevalence, is a precursor of cardiovascular diseases, resulting in high costs to the health system and increased mortality. Transcutaneous electrical nerve stimulation (TENS) is a low-frequency pulsed electrical current widely used for analgesia. Recently, it has been proposed as a non-pharmacological strategy for blood pressure control. The aim of this study is to verify the effect of low-frequency TENS when applied in different anatomical sites on blood pressure, autonomic control and endothelial function in hypertensive patients. |
JOCIANE SCHARDONG; | 2023-09-04 |
| 274 | Prevalence of Obesity Among Adult Patients With Congenital Heart Disease: A Population-based Study PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The study was conductede to examined the prevalence of obesity in a large Danish ACHD cohort, stratified according to age, sex and disease severities. To do so, ACHD patients were matched by age and sex with controls from the contemporary Copenhagen General Population Study |
ANNETTE SCHOPHUUS JENSEN; | 2023-09-01 |
| 275 | Predictors of Hospital Readmission for Patients Undergoing Cardiac Surgeries PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to identify the predictors of hospital readmission for patients undergoing cardiac surgeries. |
MAHMOUD FATHY ABDELHAFEEZ SOLIMAN; | 2023-09-01 |
| 276 | Nutritional Assessment in Children With Congenital Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart disease (CHD) defined as anatomic malformation of the heart and great vessels which occurs during intrauterine development irrespective of the age of presentation(1) It is classified into acyanotic and cyanotic depending upon whether the patients clinically exhibit cyanosis(2) . It is the most common human developmental anomaly with a reported prevalence of between 4 to 10 per 1000 live birth (3-6). The variety and severity of clinical presentation depend on the cardiac structures involved and their functional impact (7). Previous studies have found that, … |
HANAA ATIA MOHAMED HASANIN; | 2023-09-01 |
| 277 | The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surgery Involving A Sternotomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Patients awaiting cardiac surgery can experience pre-procedural anxiety. This anxiety is associated with increased analgesic needs, increased risk of mortality and prolonged recovery time. Adequate patient education can help diminish pre-procedural anxiety and minimize postoperative complications. Recent studies have demonstrated that Virtual Reality (VR) can function as a useful tool to diminish pre-procedural anxiety in several medical fields. Especially 360 degree VR could familiarize patients with their clinical pathway. Nevertheless, … |
JOLANDA KLUIN; | 2023-09-01 |
| 278 | Pre-procedural Assessment of Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI) – Comparision of Pre-TAVI CTA Vs. Pre-TAVI ICA PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ICA is not always required for a pre-TAVI workup of octogenarians and can be substituted by CTA resulting in a streamlined pre-procedural workup of patients without compromising patient safety. |
JULIA MASCHERBAUER; | 2023-09-01 |
| 279 | Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study Aim is creation of the Hospital Register of patients with heart failure with preserved ejection fraction (HFpEF) for a comprehensive assessment of the influence of gender characteristics, clinical and anamnestic factors, body composition, topical characteristics of congestion, instrumental data and markers of cellular inflammation and stress on immediate and long-term outcomes in patients with acute decompensated heart failure with preserved ejection fraction. During the study it is planned to assess gender, clinical and anamnestic indicators preceding hospitalization of patients in the hospital; characterize the features of comorbid status in the studied group of patient; … |
YURY TIMFEEV; | 2023-09-01 |
| 280 | Predictive Value of NT-proBNP on Major Adverse Cardiovascular Events in Patients With Acute Coronary Syndrome During A 6-month Follow-up PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as a cardiac biomarker in predicting short-term major adverse cardiovascular events (MACEs) in patients with Acute coronary syndrome (ACS) has been insufficiently reported and remains poorly understood. Additionally, the relationship between NT-proBNP levels and specific ACS subtypes has not been thoroughly examined. Therefore, our study investigated the predictive value of high-sensitivity cardiac troponin (hs-cTn) and NT-proBNP levels on admission for 6-month MACEs in patients who presented to the emergency department (ED) with ACS and subsequently underwent percutaneous coronary intervention (PCI). Furthermore, … |
ADEM AZ; | 2023-09-01 |
| 281 | Interstitial Lung Disease Is A Risk Factor for Cardiovascular Disease; Potential Role for Systemic Biomarkers (Krebs Von Den Lungen-6 (KL-6)) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A group of Interstitial pulmonary fibrosis will be recruited from Assiut university hospital outpatient clinic. Evaluation will be done regarding cardiovascular comorbidities (Cardiovascular comorbidities will be evaluated with thorough assessment including; history, ECG, Lipid profile and echocardiography). Lipid profile, CRP and KL-6 level will be assessed for recruited personnel. Regression analysis will be used to identify risk factors for cardiovascular comorbidities among IPF patients. |
WALEED GAMAL ELDDIN KHALEEL; | 2023-09-01 |
| 282 | Characteristics and Outcomes of Heart Failure-Related Intensive Care Unit Admissions in Adults With Cardiomyopathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To study the outcome of the cardiac function, and clinical status of the patiants with cardiomyopathy who are admitted in the I.C.U. |
MOHAMMED AHMED ABD-ELHMIED MOHAMMED; | 2023-09-01 |
| 283 | Impact of A Standing Desk Converter Intervention on Habitual Posture, Cognition, and Cardiovascular Health PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will determine the short-term impact of a standing desk converter on: 1) objectively measured physical activity and posture levels, and 2) brain (cognition) and heart (blood pressure regulation) function. The main outcome is habitual activity patterns, assessed by the thigh-worn inclinometer (activPAL). All participants will be equipped with an activPAL and have their cardiovascular and cognitive function assessed at baseline and 4 weeks. Participants in the intervention group will use a standing desk converter for 4 weeks, … |
OLGA THEOU; | 2023-09-01 |
| 284 | The Effect of Massage Applied After Open Cardiovascular Surgery on Patients’ Pain, Sleep Quality and Serum Cortisol Level PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The patient in the surgical treatment and care process has difficulty in meeting the need for sleep in the hospital, and accordingly, their habits, attitudes and behaviors regarding sleep and rest change (Yılmaz et al. 2008). Studies have shown that hospitalized patients experience sleep deprivation (Aksu and Erdoğan 2017). The decrease in sleep duration and quality is an important component affecting recovery after surgery. Studies have reported that massage reduces physical and emotional stress and increases sleep quality, while back massage reduces pain, anxiety and sleep disorders (Dreyer et al. 2015; Boitor et al. 2017; … |
YASEMİN ÖZHANLI; | 2023-09-01 |
| 285 | Validation of A Magnetic Sensor for The Non-invasive Measurement of Jugular Venous and Radial Arterial Pressure in Patients During Cardiac Catheterization PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Follow-up of patients with complex congenital heart disease (CHD) usually involves ultrasound imaging or even MRI or CT scans of the heart and stress testing. But these examinations can be challenged in terms of their sensitivity. Thus, the development of non-invasive jugular venous and radial arterial pressure sensors, reflecting the hemodynamic function of the right heart, would be very useful to the clinician responsible for early detection of a deficit in right ventricular function. |
UNIVERSITY HOSPITAL MONTPELLIER | 2023-09-01 |
| 286 | Surrogating Physician-recorded SCORE2 Risk Calculator Inputs By Using Auxiliary Data – A Cross-sectional Study in Apparently Healthy Women Aged 40 to 69 Years (Frauenherzen) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the clinical trial is to assess whether the data collected from wearable devices can reduce the uncertainty in predicting the cardiovascular disease (CVD) risk in women aged 40-69 years in a situation where information about the blood pressure and blood lipids are unavailable. Participants will: * Complete a screening and baseline assessment, including blood sample collection and vital parameter measurement. * Wear a wearable device for one week. * Fill in a work and sleep journal. * Complete a last visit assessment. |
PETRA STUTE; | 2023-08-24 |
| 287 | Impact of Percutaneous Intramyocardial Septal Radiofrequency Ablation in Obstructive Hypertrophic Cardiomyopathy on Arrhythmias PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the occurrence of various arrhythmias ( tachyarrhythmia and bradyarrhythmia ) during or after Percutaneous Intramyocardial Septal Radiofrequency Ablation. The main questions it aims to answer are: – To investigate the occurrence of various arrhythmias ( tachyarrhythmia and bradyarrhythmia ) during procedure and its relationship with clinical characteristics and procedural parameters – To analyze the changes of 12-lead electrocardiogram and 24-hour dynamic electrocardiogram before and after Percutaneous Intramyocardial Septal Radiofrequency Ablation and their relationships with clinical characteristics and procedural parameters |
LIU LIWEN; | 2023-08-22 |
| 288 | Prognostic Modeling of Heart Failure Risk in A Large-Scale Asian Cohort With Chronic Kidney Disease: The CKD-Heart Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Among patients with known chronic kidney disease (CKD) who are free from diagnosed heart failure (HF), some may be classified as stage A-B HF based on the contemporary 2022 ACC/AHA Guideline for Heart Failure Classification. Several key clinical features and risk factors have been shown to serve as predictors for future HF development. Importantly, compared to white populations, … |
CHUNG-LIEH HUNG; | 2023-08-21 |
| 289 | Impact of Colchicine on Peri-Operative Major Adverse Cardiovascular Events in Patients With Prior Coronary Revascularization PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death. Patients with heart disease undergoing major surgery are at increased risk of complications after surgery, including heart attack, stroke, and death. The proposed research seeks to better understand the role of inflammation in the damage to the heart and blood vessels after major surgery. This research also seeks to identify the potential beneficial role of a safe medication, colchicine, … |
BINITA SHAH; | 2023-08-21 |
| 290 | Effects of Increasing Anthocyanin Intake on Cardiometabolic Biomarkers in Patients With Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Flavonoids are one of the main groups of polyphenols. Anthocyanins, which are a subgroup of the flavonoid family, are found in a number of fruits and some vegetables. In epidemiological studies, high dietary intake of polyphenols has been associated with improvement of some cardiometabolic risk factors in high-risk individuals. Furthermore, in controlled studies, consumption of polyphenol-rich food sources or anthocyanin extract supplementation has improved some cardiometabolic factors. In the present study, the effect of diet enriched with anthocyanin-rich food sources on cardiometabolic factors will be studied in coronary artery disease patients. |
JAVAD NASROLLAHZADEH; | 2023-08-21 |
| 291 | Associations Between The Microbiome, Skeletal Muscle Perfusion, and Fitness Status PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: – A mouth swab to assess the bacteria in their mouths. – Produce a saliva sample into a tube. – Cycle on a bike until you reach maximum effort. – … |
JASON ALLEN; | 2023-08-14 |
| 292 | Partial Heart Transplantation for Severe Pediatric Semilunar Valve Dysfunction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if a partial heart transplantation in patients with congenital heart disease is safe and feasible. Participants will have a partial heart transplant involving surgical replacement of the pulmonary valve with the heart valve and supporting blood vessels from an organ donor. The procedure, tests, medications, and follow-up visits will all be done per standard of care. Medical data will be collected to look at outcomes after surgery. |
JOSEPH TUREK; | 2023-08-04 |
| 293 | Clinical Outcomes of Dapagliflozin in Acute Heart Failure, A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the short-term clinical outcomes of starting Dapagliflozin on the same day of hospital admission in patients with acute decompensated heart failure (ADHF). The main questions it aims to answer are: – Does early initiation of Dapagliflozin improve the length of hospital stay and in-hospital mortality in patients with ADHF? – Does early initiation of Dapagliflozin enhance the diuretic response, weight reduction and pro-BNP reduction in the acute stage of HF? – … |
HOSSAMELDIN ELSAYED KHALIFA HUSSEIN; | 2023-08-01 |
| 294 | A MHealth Intervention to Reduce Perceived Stress in Patients With Ischemic Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stress is highly prevalent in patients with ischemic heart disease (IHD) and is associated with lower health-related quality of life and worsened cardiovascular outcome. The importance of stress management is now recognized in recent cardiovascular guidelines. However, effective stress management intervention are not implemented in clinical routine yet. The development of easily disseminated eHealth interventions, particularly mHealth, may offer a cost-effective and scalable solution to this problem. The aim of the proposed trial is to assess the efficiency and cost-effectiveness of the mHealth intervention ‘mindfulHeart’ in terms of reducing stress in patients with IHD. |
JULIA LORTZ; | 2023-08-01 |
| 295 | Study on The Construction and Application of Breastfeeding Behavior Intervention Program for Mothers of Infants With Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized block trial designed to evaluate the effectiveness of a breastfeeding behavioural intervention program for mothers of infants with congenital heart disease (CHD). The purpose of this study is to compare exclusive breastfeeding rates, changes in weight-for-age z-scores (ΔWAZ) and height-for-age z-scores (ΔHAZ), and maternal breastfeeding behaviour between the intervention group and the control group at 1, 3, and 6 months of age. |
CHILDREN’S HOSPITAL OF FUDAN UNIVERSITY | 2023-08-01 |
| 296 | Psychosocial Support for Patients With Takotsubo Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study hypothesis is that participants enrolled in a virtual Takotsubo support group will have significantly less anxiety at one year. |
JIM CHEUNG; | 2023-08-01 |
| 297 | Artificial Intelligence for Preventing Heart Disease: Observational, Single Center, Prospective and Retrospective Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronary artery disease (CAD) is a leading cause of mortality in western countries. Coronary computed tomography angiography (cCTA) is the first-line imaging test in patients with suspected obstructive CAD. However, in most patients, … |
ANTONIO ESPOSITO; | 2023-07-31 |
| 298 | Prognostic Value of The Atherogenic Index of Plasma（AIP）for Cardiovascular Outcomes in Patients With Atrial Fibrillation PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about The Atherogenic Index of Plasma(AIP) in patients with atrial fibrillation(AF). The main questions it aims to answer are: (1)To investigate the correlation between AIP and the occurrence rate of AF. (2) To investigate the correlation between AIP and the occurrence rate of cardiovascular outcome events (MACE events, heart failure, embolism events) in patients with AF. Patients’s clinical data including medical history, laboratory tests, and imageological examination will be collected and further analysed. |
SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY | 2023-07-30 |
| 299 | Establishing Efficacy for The Congenital Heart Disease Physical Activity Lifestyle Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Congenital Heart Disease Physical Activity Lifestyle Intervention Study (CHD-PALS) V.2 seeks to determine the efficacy of a lifestyle intervention program for adolescents and young adults (AYAs) with congenital heart disease (CHD). This trial was adapted from the original CHD-PAL trial to continue improving cardiovascular outcomes for transition-aged CHD survivors. |
JAMIE JACKSON; | 2023-07-18 |
| 300 | Istanbul University-Cerrahpasa, Florence Nightingale Faculty of Nursing, Department of Medical Nursing PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the effect of planned education given to individuals with diabetes mellitus who had myocardial infarction on healthy lifestyle behaviors and diabetes self-management. |
ARZU ERKOC; | 2023-07-15 |
| 301 | Polish Registry of Coronary Artery Aneurysms and Ectasias. Coronary ARtery Ectasia Database – Poland (CARED-POL) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to comprehensively investigate the current prevalence, morphological characteristics, risk factors for the development, complications as well as long-term prognosis of coronary artery aneurysm and ectasia (CAAE) in the Polish population. Data obtained from the CARED-POL Registry will enable the selection of morphological risk factors for the unfavorable course of CAAE, including the progression and development of giant aneurysms, aneurysm clotting with vessel occlusion, and thromboembolic complications. Comparing the safety and effectiveness of available CAAE treatment methods in individual patient subgroups will allow individualization of treatment, including anticoagulant therapy. |
SYLWIA IWANCZYK; | 2023-07-14 |
| 302 | HEARTPrep: A Virtually-delivered Psychosocial Intervention for Mothers Expecting A Baby With Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart disease (CHD) is the most common birth defect and is increasingly diagnosed prenatally. Mothers describe their prenatal experiences as highly stressful and traumatic after a diagnosis of CHD. Maternal stress during pregnancy exerts a powerful influence on birth outcomes and developmental trajectories, particularly for children in underserved populations. In partnership with diverse parent and clinician stakeholders, our team designed HEARTPrep, an innovative, … |
ERICA SOOD; | 2023-07-14 |
| 303 | The Effect of Eye Mask Applied on Patients Undergoing Coronary Artery Bypass Graft Surgery on Sleep Quality and Pain: Double-Blind Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Coronary Artery Bypass Graft (CABG) performed with open heart surgery technique is a successful operation in the treatment of cardiovascular diseases. Incision of the sternum region, saphenous vein graft, sternal retraction, presence of chest and mediastinal tubes cause pain. The pain experienced by the patients, the complications related to the disease they have, and the stress they experience cause an increase in sleep problems. In addition, the increase in sympathetic activity after surgery and nursing care interventions also affect sleep quality. The literature reports that sleep disorders affect the working physiology of the heart in patients with cardiac disease, … |
NECIBE DAĞCAN; | 2023-07-10 |
| 304 | The Efficacy of Three Doses of Live Attenuated, Oral Rotavirus Vaccine 116E (ROTAVAC 5D) in Chilean Infants PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, phase 3 study to evaluate the Efficacy,Safety, and Immunogenicity of ROTAVAC 5D, a live attenuated rotavirus vaccine in healthy infants aged 6-8 weeks. A total of 5800 healthy Chilean infants will be recruited in this study and randomized to receive either vaccine or placebo in 1:1 ratio. Among these participants 300 will be categorized to immunogenicity cohort, 150 from each group, and blood samples will be collected to assess the immune response. |
BHARAT BIOTECH INTERNATIONAL | 2023-07-07 |
| 305 | Combined Effects of Active Cycle of Breathing Technique and Autogenic Drainage in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomised controlled trial will be conducted with COPD patients as its target population. There will be 40 individuals for both the control group and the intervention group. Group A is a control group while Group B is an experimental group (20 participants on Group A and 20 on group B). The baseline treatment for both groups were pursed lip breathing and ACBT. On the other hand, … |
SIDRA AFZAL; | 2023-07-05 |
| 306 | Early-phase Exercise-based Comprehensive Cardiac Rehabilitation Program After Myocardial Infarction: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to investigate the effects of early-phase exercise-based supervised cardiac rehabilitation on functional exercise capacity, grip strength, fatigue, sleep quality, and health-related quality of life. |
OZGE OCAKER AKTAN; | 2023-07-03 |
| 307 | Digital Intervention for School-going Adolescents: A Serious Games Approach for Cardiovascular Health Promotion in Nepal PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this HRIDAYA project is to see if a digital mobile game can improve knowledge about heart disease among school-going adolescents. The researchers will divide adolescents of public and private schools into two groups. Each group will contain adolescents from both the school types. Knowledge, attitude and practice (KAP) of adolescents will be tested before intervention. One group will receive a mobile game and the other will not receive the game. After two weeks of game play, … |
DAYANA SHAKYA; | 2023-07-02 |
| 308 | The Application of Enhanced Recovery After Surgery (ERAS) for Cardiovascular Surgery in The Correction of Complex Congenital Heart Disease: A Stepped Wedge Cluster Randomized Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter, stepwise design, cluster randomized controlled trial. Random sequence is generated by computer, and each center enters the intervention expectation (Phase I) in random order to implement ERAS strategy. If it does not enter the intervention expectation (Phase C) center, clinical diagnosis and treatment will be completed according to the traditional scheme. Among children, patients aged 28 to 6 who underwent cardiac surgery were included in the ERAS strategy intervention plan, which mainly includes preoperative education, preoperative comfort for the patient, preoperative oral sugary beverage, continuous infusion of dexmedetomidine, multimodal analgesia, blood protection strategies, … |
YAN FUXIA; | 2023-07-01 |
| 309 | A Multi-center, Single Arm, Real-World Registry Assessing The Clinical Use of The Cera™ VSD Occluder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this post-market registry is to assess the safety and performance of the Lifetech Cera™ VSD occluder in a real-world and on-label fashion. |
JOU-KOU WANG; | 2023-07-01 |
| 310 | A Study on The Impact of Bivalirudin Usage During Percutaneous Coronary Intervention for High-risk Plaques in The Coronary Artery on Post Percutaneous Coronary Intervention Coronary Microcirculation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, investigators enrolled patients with coronary heart disease who were scheduled to undergo percutaneous coronary intervention (PCI) and had high-risk plaques according to computed tomography angiography (CTA). During the PCI procedure, patients will be randomly assigned to receive either bivalirudin or standard heparin anticoagulation therapy. Investigators will compare the post-PCI coronary angiography-derived index of microcirculatory resistance (CaIMR), thrombolysis in myocardial infarction (TIMI) blood flow grade, CTFC (corrected TIMI frame count), TIMI myocardial perfusion grading(TMPG), levels of troponin, … |
ZHENG BO; | 2023-07-01 |
| 311 | The Effect of 3D Modeling on Family Quality of Life, Surgical Success and Patient Outcomes in Congenital Heart Diseases: A Randomized Controlled Trial Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction and Objective: In recent years, 3D (three-dimensional) modeling has been added to traditional and effective diagnostic methods such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI), … |
AYLIN AKÇA; | 2023-07-01 |
| 312 | Effect of Propionic Acid Supplementation on Endothelial Function in Patients With Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronary Artery Disease (CAD) remains a leading cause of morbidity and mortality worldwide despite improved mitigation of traditional risk factors. Large association studies have linked the gut microbiome alterations with inflammation, CAD, and traditional CAD risk factors. Subsequent studies have shown concomitant improvements in gut dysbiosis, inflammation, and cardiometabolic diseases using probiotics and other gut-modulating therapies. To date, many studies have shown a correlative relationship between intestinal bacteria composition and the presence of CAD, or severity of heart attacks, … |
MICHAEL E. WIDLANSKY; | 2023-07-01 |
| 313 | Can Resistance Training Bring Additional Benefits to A Cardiac Surgery Exercises Based Prehabilitation Program? Protocol for A Non-randomized Controlled Clinical Study of Valvular Heart Disease Patients. Cardiac EBPrehab PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiovascular diseases (CVD) are a group of illnesses that include coronary heart disease, cerebrovascular disease, congenital heart disease, and deep vein thrombosis. CVD is the leading cause of mortality worldwide, representing 31% of deaths. In Spain, … |
JORGE MONTERO CÁMARA; | 2023-07-01 |
| 314 | Support Tool for Families of High-Risk Children With Heart Disease During Hospital Admission and After Discharge Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to pilot the support tool in the Nemours Cardiac Center to assess acceptability and feasibility. This tool will be offered to 5 high-risk families, and they will be asked to complete a survey. In addition, healthcare providers including bed-side nurses and cardiologists will be asked to complete a survey to assess the feasibility of the tool. |
DEEPIKA THACKER; | 2023-07-01 |
| 315 | International Cardiac Amyloidosis Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiac amyloidosis is a relatively rare disease. However, with the newer imaging techniques that have become available to us in recent years, determining the diagnosis is becoming more common. There are several variants. Each variant involves protein accumulation between heart muscle cells. This leads to the heart stiffening and, as a result, the heart has a hard time filling. This can lead to heart failure with complaints such as fluid retention, cardiac arrhythmias such as atrial fibrillation, conduction abnormalities that sometimes require a pacemaker, … |
NINA AJMONE MARSAN; | 2023-06-30 |
| 316 | The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether CABG compared to PCI is associated with a reduction in all-cause death, stroke, spontaneous myocardial infarction (MI), urgent repeat revascularization (RR), … |
STEPHEN E. FREMES; | 2023-06-22 |
| 317 | Exploratory Analysis of Enhanced Liver Function (ELF) Test to Detect Early Fatty Liver in High Risk Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this initial investigator-initiated retrospective study, aim to analyze the enhanced liver fibrosis (ELF) scores in this high-risk population for NAFLD/nonalcoholic steatohepatitis(NASH)-related fibrosis. Study define ‘high-risk’ to include metabolic syndrome, which can be further defined by an atherosclerotic cardiovascular disease (ASCVD) score >7.5, any diagnosis of hyperlipidemia, history of coronary artery disease, history of heart failure, hypertension and/or type 2 diabetes. Study would also like to compare the performance of this score with historical methods of fibrosis assessment, where applicable, including vibration-controlled transient elastography, magnetic resonance elastography, … |
PARVEZ MANTRY; | 2023-06-20 |
| 318 | Effects of Multicomponent Training Versus Cardiovascular Training As A Treatment for Hypertension in Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypertension is the most prevalent risk factor and the third leading cause of death worldwide, responsible for an increase in cardiac events. International guidelines on cardiology and hypertension recommend the practice of regular physical exercise for the control and treatment of this disease. The main objective of the study will be to determine the effect of a Multicomponent Training programme versus a Cardiovascular Training programme on blood pressure levels in hypertensive adults. The work methodology will consist of a controlled, randomised, longitudinal and prospective clinical trial, with several simultaneous study branches; on the one hand, the interventions with Multicomponent Training; … |
NOELIA GONZÁLEZ-GÁLVEZ; | 2023-06-20 |
| 319 | Effect of High-intensity Intermittent Rehabilitation Training on Cardiopulmonary Function After PCI in Patients With Coronary Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Both the gut microbiome and exercise are closely related to human health, but the understanding of the effect of high-intensity interval training (HIIT) on cardiopulmonary function and human intestinal flora is still further study. |
CHEN LEILEI; | 2023-06-17 |
| 320 | Health Monitoring of Elderly Hypertensive Patients in Tianjin, China PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to monitor the health of elderly hypertensive patients in Tianjin. |
TIANTIAN LI; | 2023-06-15 |
| 321 | A Health-risk Early-warning Intervention for Heat Waves and Cold Spells in Older Hypertensive Patients in Tianjin, China: An Open, Cluster-randomised Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was designed to explore the impact of health-risk early-warning interventions for heat waves and cold spells on older hypertensive patients. |
TIANTIAN LI; | 2023-06-15 |
| 322 | Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Basic Autonomic Nervous System Activity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There are no generally accepted values for transcutaneous vagus nerve stimulation (taVSS application parameters (amplitude, frequency, intensity, duration, side) yet, therefore there are heterogeneous applications in studies. Although positive effects have been shown in different neurological, psychiatric and musculoskeletal diseases, taVSS treatment is not available yet. It is not clear which parameters are important in patient selection.In this study, it was aimed to investigate the change of taVSS effect in healthy individuals according to the level of autonomic nervous system activity before stimulation. |
ALPER PERCIN; | 2023-06-15 |
| 323 | The Effects of Dexmedetomidine on Thiol/Disulphide Homeostasis in Coronary Bypass Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dexmedetomidine (DEX) is a sedative and anesthetic drug with known antioxidant properties.In this study, it was aimed to investigate the oxidative stress levels in patients undergoing on-pump CABG by measuring the thiol/disulfide levels and to investigate the effects of dexmedetomidine infusion used in Coronary Bypass Surgery on dynamic Thiol/Disulphide Homeostasis. |
YUSUF ÖZGÜNER; | 2023-06-05 |
| 324 | Surgical Ablation of AF Efficacy Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: SAFE is an international multicentre RCT of concomitant surgical atrial fibrillation (AF) ablation in patients with paroxysmal or persistent AF undergoing cardiac surgery. |
RICHARD WHITLOCK; | 2023-06-01 |
| 325 | The Efficacy And Safety Of Metformin For The Treatment Of Atrial Fibrillation PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this multicenter, pragmatic, open-label, randomized, placebo-controlled clinical trial is to test whether repurposing metformin for the treatment of atrial fibrillation will be effective in decreasing patients’ hospitalization, adverse major cardiovascular events, and non-cancer death. Participants will be randomized into 2 study arms (385 participant each), whereby: – The Metformin Group (MG): will receive metformin oral tablets in addition to the standard rate/rhythm control strategy and anticoagulation. – … |
ESLAM ABBAS; | 2023-06-01 |
| 326 | A Prospective Single-Arm Multicenter Study Evaluating Use of The CORA Catheters for The Crossing of Coronary Chronic Total Occlusions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the safety and effectiveness of the coraFlex, coraForce, and coraCross catheters for crossing chronic total occlusions of the coronary arteries. The study will compare the rate of procedure success to success rates from previous trials. Participants will undergo percutaneous coronary intervention (PCI) for a chronic total occlusion and be followed for 30 days post-procedure. |
LORENZO AZZALINI; | 2023-06-01 |
| 327 | Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases (Including Pediatric Inflammatory Multisystemic Syndromes Related to Covid 19, Kawasaki Disease and Myocarditis) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS). These 3 inflammatory cardiac diseases have clinical, biological, and echographic similarities and differences. Nevertheless their modalities of monitoring, management and evolution are different. The investigators wish to retrospectively analyze biological and echocardiographic data of Kawasaki disease, myocarditis, PIMS patients managed at Nancy Children Hospital from January 1, 2017 to June 31, 2023. The primary objective of this study is to identify, for these 3 pathologies, … |
BOSSER GILLES; | 2023-06-01 |
| 328 | Cardiac Risk Assessment Using Standard of Care Versus CTA and Heart Flow FFRct in Patients With End-Stage Liver Disease Under Consideration for Liver Transplant PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronary Artery Disease (CAD) is the narrowing or blockage of the artery of the heart and is prevalent in end-stage liver disease. Consultation with cardiologist and stress tests are recommended to patients under consideration for liver transplant. The purpose of this study is to evaluate if Computed Tomography Angiogram (CTA) and CTA-derived Fractional Flow Reserve (FFRct) procedure influences decisions about further cardiac testing compared with Standard of Care (SOC) such as consultation by a cardiologist, Echocardiogram (ultrasound of the heart), Electrocardiogram (ECG) and stress tests. |
ROBERT SAFIAN; | 2023-06-01 |
| 329 | Evaluating A Preventive Heart Health Programme for Perimenopausal Women – Empowering Sustainable Healthy Habits Through Behaviour Change Strategy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines the factors that limit or support the implementation of a pilot heart health program for perimenopausal women. The investigators evaluate the effectiveness of this program in raising awareness and promoting behavior change to maintain cardiovascular health. |
ALEXANDRA HOSPITAL | 2023-06-01 |
| 330 | Prevalence of Aspirin Resistance in Ischemic Stroke Patients at Assiut University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: – This study aims to assess the prevalence of aspirin resistance in patients with acute ischemic stroke and its importance in secondary stroke prevention. – Effect of aspirin resistance on short and long term mortality and detection of its relationship with recurrence of stroke. |
AHMED SAEED MOSTAFA; | 2023-06-01 |
| 331 | Strong Hearts: A Remote, App-Enabled, Exercise Program for Patients With Congenital Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this program is to create a remote, mobile application enabled exercise program for patients with CHD (Congenital Heart Disease). Pilot trials will consist of a remote exercise program with app-embedded exercise modules designed to promote and encourage safe and healthy exercise habits across a range of CHD anatomies. This app-enabled program will allow for real time data collection integrating wearable devices, as well as compliance and safety monitoring to enhance research capabilities. The app-enabled program will be versatile and may be applied in the future to patients with non-cardiac conditions. |
REID C CHAMBERLAIN; | 2023-06-01 |
| 332 | A Longterm Follow-up and Comparison of Morbidity and Heart Health Between Patients With Pulmonary Atresia With Intact Ventricular Septum and Uni- or Biventricular Circulation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare patients with pulmonary atresia with intact ventricular septum (PA-IVS) with univentricular circulation to patients with the same heart defect but that has a biventricular circulation in regards to mortality, quality of life, comorbidity, cardiac function, and work capacity. The main questions the study aims to answer are: • Do mortality, quality of life, comorbidity, cardiac function, … |
STINA MANHEM; | 2023-06-01 |
| 333 | The Effects of Ketone Ester Supplementation on Nocturnal Blood Pressure in Middle-Aged and Older Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiovascular disease (CVD) is the number one cause of death globally and high blood pressure (i.e., hypertension) is the leading modifiable risk factor for CVD and all-cause mortality. Advancing age is the primary risk factor for hypertension and CVD. Moreover, compared to younger adults, older adults exhibit reduced nocturnal dipping of blood pressure resulting in elevated nighttime blood pressure values, which are a better predictor of cardiovascular outcomes than daytime blood pressure. Intriguingly, recently published rodent data suggests that ketone supplementation protects against hypertension, blood vessel dysfunction, … |
GREGORY J GROSICKI; | 2023-06-01 |
| 334 | Prevalence of Cusp Asymmetry , Coronary Ostial Eccentricity in Patients Undergoing Trans Catheter Aortic Valve Implantation and Their Impact on Coronary Ostial OverlaP Risk Assessment: An Egyptian CO-OPRA Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to measure the prevalence of Cusps asymmetry, coronary Ostial eccentricity in patients with severe aortic stenosis undergoing Trans-catheter Aortic Valve Implantation (TAVI) and measure the degree of coronary ostia overlap with trans-catheter neo-commissure. The main question it aims to answer is: Do coronary ostial eccentricity or cusp asymmetry have impact on coronary ostia overlap with trans-catheter neo-commissure? Participants already taking TAVI as part of their regular medical care for severe symptomatic aortic stenosis will do post procedural ECG-gated non contrast Multi-detector Computed Tomographic Angiography (MDCTA). |
AIN SHAMS UNIVERSITY | 2023-06-01 |
| 335 | Association Between Coronary and Peripheral Vascular Injury in Heart Failure Patients With Preserved Ejection Fraction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure with preserved ejection fraction (HPEF, defined as LVEF ≥50%) represents 50% of hospital admissions for heart failure. Although its morbi-mortality is similar to that of heart failure with reduced ejection fraction (HFPEF), it remains an unknown disease with limited data especially from an etiological point of view. The underlying causes are imperfectly understood, and more than half of the patients have HPEF labeled idiopathic. A non-hierarchical clustering study of HPEF patients led to the identification of a subgroup of patients (25%) with a predominant coronary vascular phenotype (i.e., … |
ROXANE GAÏSSET; | 2023-06-01 |
| 336 | The Effects of A Psychosocial Dyadic Intervention on The Mutuality, Psychological and Quality of Life Outcomes of Patients With Heart Failure and Their Family Caregivers: A Mixed-methods Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aim of the study is to evaluate the effects of a psychosocial dyadic intervention on mutuality, psychological strengths (i.e., resilience and self-compassion), psychological distress (i.e., anxiety and depression), and QoL outcomes of HF patients and caregivers. The HF patient-caregiver dyads will be randomly allocated to the intervention group to receive a 12-week relationship-focused psychosocial dyadic intervention, or to the control group to receive the usual care provided by the clinical team in the hospital. |
CAN XIONG; | 2023-05-30 |
| 337 | Dongzong Cardiovascular Bio-imaging Registry Study PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The DAILY project is a large-scale, multicenter, prospective initiative designed to establish a comprehensive bio-imaging database that integrates multidimensional data, including living environments, psychosocial and cognitive assessments, advanced lung and cardiovascular imaging, multi-omics profiles, clinical medication and surgical records, and health outcomes. Leveraging this extensive, multiscale dataset, the project aims to elucidate the intricate interplay between genetic biology and environmental factors in driving downstream biological alterations, thereby shaping lung and cardiovascular structural and functional phenotypes, and ultimately influencing the onset and progression of cardiovascular diseases (CVD). Through a systematic exploration and understanding of this complex network, … |
ZHANG LONGJIANG; | 2023-05-24 |
| 338 | Middle East African Registry Women CardioVascular Disease PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The MEA cardiology societies have joined forces to tackle the issue by establishing a tangible real-world data registry in every MEA country. This endeavor has resulted in the development of a multicenter registry called MEA-WCVD, which is being sponsored by each national cardiology society from participating countries. All data gathered will be consolidated into a singular registry for thorough analysis. Country specific analysis will be performed. |
TUNISIAN SOCIETY OF CARDIOLOGY AND CARDIOVASCULAR SURGERY | 2023-05-10 |
| 339 | Online Group Therapy to Improve Depression, Anxiety and Psychological Well-being in Mothers of Babies With Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Mothers of babies with congenital heart disease tend to have higher levels of depression, stress and anxiety. Currently, psychological support group technology has been a resource increasingly used by health professionals, with a therapeutic objective as an instrument to promote care. Objective: The aim of this study is to evaluate the effectiveness of a group intervention in improving depression, anxiety and the psychological well-being of mothers of babies with congenital heart disease. Methods: Randomized, parallel clinical trial, in which the factor under study will be online group therapy and the outcome the level of depressive symptoms, … |
MARCIA M SCHMIDT; | 2023-05-10 |
| 340 | A CCTA Image Assisted Triage Software for The Assessment of Patients With Suspected Coronary Artery Disease: A Retrospective, Multi-center, Blind-evaluation Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trail is to evaluate the effectiveness and accuracy of the CCTA image assisted triage software(DeepVessel® Cardisight, Keya Medical.) for the triage of patients with suspected coronary artery disease. |
BIN LU; | 2023-05-09 |
| 341 | The Effect of Psychosocial Nursing Interventions on Sleep, Anxiety and Delirium in Patients Undergoing Open Heart Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to determine the effects of psychosocial nursing interventions applied to a patient with cardiac surgery on sleep quality, anxiety and delirium. Are psychosocial nursing interventions applied to a patient with cardiac surgery effective in preventing delirium? Are psychosocial nursing interventions applied to a patient with cardiac surgery effective on sleep quality? Are psychosocial nursing interventions applied to a patient with cardiac surgery effective on the level of anxiety? |
FİRDEVS EBRU ÖZDEMİR; | 2023-05-09 |
| 342 | Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-market, prospective, multi-center, single-arm observational study to generate real-world clinical evidence associated with coronary IVL in a population of female subjects with calcified coronary artery disease. |
SHOCKWAVE MEDICAL | 2023-05-03 |
| 343 | Risk Stratification of Ischemic and Non-ischemic Cardiomyopathies in Racial and Ethnic Minority Groups in The Bronx – Cardiovascular Multimodality Imaging Study PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Determining the etiology of cardiomyopathy is of high clinical importance for optimal treatment strategy and prediction of prognosis. There is increased risk for cardiovascular disease and higher propensity for cardiovascular related mortality among Black and non-Hispanic White patients. Recently, advanced cardiac imaging has become a vital tool in diagnosis and risk stratification of cardiovascular disease. Very limited data is available on the prevalence and characteristics of different cardiovascular diseases in Hispanic and African American minority groups, therefore, … |
LEANDRO SLIPCZUK; | 2023-05-01 |
| 344 | Chronic Coronary Syndrome in Swedish Primary Care PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about a new procedure for investigation of possible coronary heart disease and to see if it is faster, cheaper or more expensive, promotes healthier behavior, mental well-being, adherence to drugs for heart protection and the risk for cardiac events like acute myocardial infarction over years to come. The novelty in the procedure is that a myocardial perfusion scan to assess blood flow to areas of the heart muscle, echocardiography i.e., heart ultrasound and heart CT scan comes as a package investigation performed on the same day. According to existing routines, … |
STAFFAN NILSSON; | 2023-05-01 |
| 345 | Nasal Intermittent Positive Pressure Ventilation (NIPPV) During Neonatal Endotracheal Intubation: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to determine whether the use of nasal intermittent positive pressure ventilation (NIPPV) during neonatal endotracheal intubation increases the rate of successful intubation without physiological instability during all intubation attempts. The present study was designed as a prospective, multicenter, randomized, controlled study conducted with neonates undergoing endotracheal intubation. The infants were assigned randomly to either the NIPPV group or the standard care group. |
OZKAN ILHAN; | 2023-05-01 |
| 346 | Determination of Dickkopf-3 Rs11544814 and Complement Factor H Rs10737680 Genetic Polymorphism and Change in Their Protein Levels Before and After Non Surgical Periodontal Therapy in Periodontitis Patients With and Without Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Untreated periodontal infection may result in transient bacteremia and toxaemia which may be the cause of adverse systemic events, leading to various systemic disorders. Amongst all the systemic diseases, … |
JAIDEEP MAHENDRA; | 2023-05-01 |
| 347 | Impact of Rotational Atherectomy on Coronary Microvascular Function in Patients With Stable Angina and Calcified Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this observational study is to compare the impact of rotational atherectomy to conventional stenting and to investigate how it may affect coronary microcirculation in patients with calcified coronary artery lesions and stable CAD. The study’s objectives are to: – investigate the impact of rotational atherectomy on the prevalence of post-percutaneuos coronary intervention coronay microvascular dysfunction; – investigate the impact of conventional stenting on the prevalence of post-percutaneuos coronary intervention coronay microvascular dysfunction; and – … |
ALI ALDUJELI; | 2023-05-01 |
| 348 | Efficacy of A Novel Web-based Physical Activity Intervention Designed to Promote Adherence to Physical Activity Guidelines in Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study insufficiently active adults with obesity will be assigned to either the Physical Activity for The Heart (PATH) intervention or an attention control group. |
JACOB KARIUKI; | 2023-05-01 |
| 349 | Safety and Efficacy of Pediatric Cardiac Telerehabilitation in Adolescents with Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiac telerehabilitation is a much-needed pediatric therapy; however, a lack of randomized controlled trials has limited the development of and reimbursement for this valuable service. Through this prospective, randomized controlled trial, the investigators aim to demonstrate the safety and efficacy of PCTR in a clinically diverse population of children and adolescents with heart disease. |
AIMEE LAYTON; | 2023-05-01 |
| 350 | Evaluation of Risk Factors, Clinical Pattern and Outcome of Thrombosis in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pediatric thrombosis is multifactorial, and usually risk factors either congenital or acquired are present. Patient may has one risk factor or more such as sepsis, cancers, congenital heart disease, post surgery , central venous catheter insertion, nephrotic syndrome, systemic lupus erythromatosis and inflammatory bowel disease. If there’s no obvious risk factor for thrombosis, hereditary thrombophilia is suspected which results when an inherited factor, such as antithrombin , protein C or protein S deficiency. |
HAIDY ABDELAZIM YOUSSIF; | 2023-05-01 |
| 351 | AnGiographic Performance Following PCI With A Sirolimus-elutiNG Balloon in The TrEatment of De Novo CoronaRy Artery Disease: GINGER Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate angiographic performance in long lesions of Sirolimus Eluting Balloon Magic Touch by Concept Medical |
FONDAZIONE EVIDENCE PER ATTIVITÀ E RICERCHE CARDIOVASCOLARI ONLUS | 2023-05-01 |
| 352 | Common Cases in Pediatric Intensive Care in Assuit University Cardiology Institute, A Clinical Audit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1Evaluation of the management methods according to guidelines for cardiac patients admitted to Intensive care in pediatric Assuit university cardiology institute and the effectiveness and outcome of following of these medications comparing them with international advanced centers. Types of shocks in cardiac patients and management of cardiogenic shock needs especial concern. |
MARTINA THARWAT ATTIA SALAMA; | 2023-05-01 |
| 353 | Predictors Of Chronic Thromboembolic Pulmonary Hypertension Following Acute Pulmonary Embolism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Identify risk factors for developing chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Determine echocardiographic predictors of chronic thromboembolic pulmonary hypertension. Determine the radiological predictors of chronic thromboembolic pulmonary hypertension in CT pulmonary angiography. |
ASMAA GAMAL ABD ELHAMIED; | 2023-05-01 |
| 354 | Impact of The Whole Food Plant-Based Diet in HIV-Associated Reduction in Cardiovascular Risk PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the impact of using a whole food plant-based diet in the reduction of cardiovascular risk related to HIV in people who live with HIV infection. The main questions it aims to answer are: – Does a whole food plant-based diet, nonrestrictive in calories and low in fat, reduce the cardiovascular risk associated with HIV infection in people with HIV infection? – Does the whole food plant-based diet permit achievement goals in specific metabolic markers of cardiovascular risk (such as Cholesterol, C Reactive Protein)? Participants will follow a non-calorie restricted, low fat, … |
CAROLINA MARTÍNEZ LOYA; | 2023-05-01 |
| 355 | The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus people have a higher incidence of cardiovascular disease, and the results of cardiovascular events are worse. Heart failure and diabetes both have a worse prognosis, with a 1.5-2 times increased risk of death. Data from the literature have shown that MET lowers mortality by 14-35% in this patient population, which represents one-third of all HF patients with no increases in lactic acidosis incidence. |
SARA ELADAWY; | 2023-05-01 |
| 356 | An Open-Label, Non-randomized, Multi-center Pilot Study to Evaluate The Safety and Efficacy of 4-week, Daily Oral Use of Dapagliflozin 10mg Tablet in Adults With A Fontan Circulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to study if an investigational study drug called Dapagliflozin could prevent heart failure from getting worse in adults with Fontan circulation. The main questions it aims to answer are: 1. Does Dapagliflozin decrease Fontan pressure? 2. Does Dapagliflozin improve exercise capacity and heart failure symptoms? Participants will have 4 study visits and 2 follow-up phone calls. The total duration of participation in the study will be up to 5 weeks from the time of screening to the completion of the final safety evaluation. Study procedures include the collection of study-related health information and blood samples, physical examination, exercise testing, total body water assessment, blood laboratory testing, health status survey, safety evaluation phone calls, and home blood pressure monitoring. |
ARI CEDARS; | 2023-05-01 |
| 357 | A Post-Market Clinical Follow-up Study With Ultimaster Nagomi™ Sirolimus Eluting Coronary Stent System in Complex PCI Subjects PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The NAGOMI COMPLEX PMCF (Post-Market Clinical Follow-up) study has been designed to expand the knowledge about outcomes with the Ultimaster Nagomi™ sirolimus eluting coronary stent system (Ultimaster Nagomi™) in complex PCI subjects. The features for a complex PCI are based upon subgroup analysis of earlier published studies. |
HANNES ALBER; | 2023-04-25 |
| 358 | Impact of Stress on Cardiovascular Events in Patients with Peripheral Arterial Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality worldwide. Patients with peripheral arterial disease are at increased risk suffering from major adverse cardiac and limb events. Acute and chronic stress affect the cardiovascular system. Long-term negative stressors lead to cardiovascular diseases and can aggravate already existing cardiovascular diseases. However, … |
UNIVERSITY HOSPITAL ESSEN | 2023-04-21 |
| 359 | The Effects of Dietary Supplementation Allicor on Patients With Multifocal Atherosclerosis After Peripheral Artery Revascularization Treatment During A Year PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A significant challenge in medical care is atherosclerotic occlusion of peripheral arteries, such as lower extremities and brachiocephalic arteries, which can eventually lead to loss of limbs or fatal ischemic strokes. Revascularizing surgical interventions can restore the lumen of the arteries and provide an effective way to treat such patients. However, … |
NIKOLAY K SHAKHPAZYAN; | 2023-04-20 |
| 360 | Investigation of Activities of Daily Living, Cognition and Muscle Strength in Individuals With Frailty and Non-Fragile Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart disease (CHD) is defined as congenital functional or anatomical abnormalities of the heart and intrathoracic great vessels. This study, which is planned to be carried out, will enable people with CHD to present a holistic perspective when planning rehabilitation programs and to create a common language for all health professionals. |
CEYHUN TOPCUOGLU; | 2023-04-20 |
| 361 | The Clinical Application of Magnetocardiography (MCG) As A Non-invasive Diagnostic Tool for Evaluating Myocardial Ischemic Function in Patients With Stable Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this observational study is to evaluate the diagnostic effectiveness of magnetocardiography (MCG) in patients with stable coronary artery disease (SCAD) and compare it with coronary CTA (CCTA). Additionally, the study aims to determine the most suitable diagnostic index for MCG. The primary question it seeks to address is whether MCG or MCG combined with CCTA can be utilized to guide the clinical application of percutaneous coronary intervention (PCI) for coronary heart disease. |
NANHAI HOSPITAL GUANGDONG PROVINCIAL PEOPLE’S HOSPITAL | 2023-04-19 |
| 362 | An Open-Label, Two-Part Sequential Study Designed to Assess The Mass Balance Recovery, Absorption, Metabolism, Excretion of [14C]AZD0780 and The Absolute Bioavailability of AZD0780 in Healthy Male Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Sponsor is developing a new test medicine, AZD0780, with the aim to lower low-density lipoprotein cholesterol (LDL-C, fatty deposits) levels and cardiovascular (heart disease) risk, when given on top of standard care. This two-part healthy volunteer study will try to identify how the test medicine is taken up, broken down and removed from the body. To help investigate this, the test medicine is radiolabelled, which means that the test medicine has a radioactive component (carbon-14; … |
SOMASEKHARA MENAKURU; | 2023-04-19 |
| 363 | Venous Ethanol for Ischemic Left Ventricular Tachycardia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparative effectiveness randomized clinical trial, comparing endocardial radiofrequency ablation alone vs radiofrequency ablation combined with venous ethanol in patients with ischemic ventricular tachycardia -Venous Ethanol for Left Ventricular Ischemic Ventricular Tachycardia -VELVET clinical trial |
MIGUEL VALDERRABANO; | 2023-04-12 |
| 364 | A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method） PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate diagnostic performance of N-terminal Brain natriuretic Peptide (NT-proBNP) in acute heart failure among Chinese population. Further, it sought to explore the optimal cut-off point fitting Chinese patients. |
BECKMAN COULTER | 2023-04-10 |
| 365 | Prognostic Significance of Inflammatory Biomarkers and LV Functionin Patients With Coronary Heart Disease and Heart Failure PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The association of novel inflammatory biomarkers with cardiovascular diseases is still obscure. The present study aimed to investigate the relationship of various inflammatory biomarkers with the existence as well as the extent of heart failure (HF) and coronary artery disease (CAD), suggesting a link between inflammation and cardiovascular diseases and all-cause 30- and -90 day of hospital readmission. Methods: We enrolled a total of 120 patients with HF, asymptomatic CAD and 60 healthy controls (HC) without cardiovascular diseases. |
REHAB WERIDA; | 2023-04-10 |
| 366 | Impact of A Neuro-cardiac Rehabilitation Program on The Quality of Life of Children, Adolescents, and Young Adults With Congenital Heart Disease: The Multicentre Randomized Controlled QUALINEUROREHAB Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Neurodevelopmental impairments and physical deconditioning are the leading causes of long-term morbidity in patients with congenital heart disease (CHD). These public health issues worsen during school age and adolescence and have major consequences on the quality of life (QoL) of children and their families. A holistic rehabilitation program, using a combined neuro-cardiac intervention, has the potential for the long-term improvement of their physical and mental health outcomes. A novel neuro-cardiac rehabilitation program is proposed, in a multicentre randomized controlled trial, measuring the impact of a holistic heart-brain intervention on the quality of life, … |
UNIVERSITY HOSPITAL BORDEAUX | 2023-04-01 |
| 367 | Randomized Controlled Trial for Evaluating CYP2C19 Allele Genotype-guided Clopidogrel Treatment Outcomes in Real-world Practice After The EPCI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study purposed to learn how clopidogrel-based antiplatelet treatment for preventing adverse cardiovascular events after ePCI works in chronic coronary artery disease when guided by personal genetic characteristics for drug metabolism. The study aimed to answer two research questions: – Does CYP2C19 genotype-guided clopidogrel treatment provide better clinical outcomes when compared with conventional treatment selection led without CYP2C19 genotyping? – Can CYP2C19 genotype-guided antiplatelet treatment be beneficially applied in real-world clinical practice? After obtaining the informed consent eligible study participants screened by inclusion and exclusion criteria were randomized and allocated into two groups: – … |
KONSTANTINE LILUASHVILI; | 2023-04-01 |
| 368 | Ambulatory Leadless Electrocardiogram Recorder Trial (ALERT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to compare the heart signals that are received by a new heart monitoring device called the HeartWatch to heart signals that are recorded by existing monitors used in cardiology clinics today. The main question[s] it aims to answer are: 1. Does the HeartWatch recording allow characterization of tagged and abnormal arrhythmia events that are equivalent to the existing Event Recorder and Holter devices? 2. Does the HeartWatch recording allow for detection of QRS complexes that are equivalent to the predicate Holter lead I reference signal? Participants who have been recommended to receive a heart monitor for heart rhythm assessment will asked to wear the HeartWatch armband monitor at the same time as the standard heart monitor. They will be asked to flag symptoms (if they occur) on either the HeartWatch or on the Helpwear Smartphone. When their monitoring session for the standard heart monitor is complete, then the monitoring session for the HeartWatch armband is also complete. |
HELPWEAR | 2023-04-01 |
| 369 | The Use of Electrocardiography-based Estimation of Heart Age to Improve Blood Pressure in A Primary Care Setting – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Successfully communicating cardiovascular risk to patients is essential for achieving compliance to medication and lifestyle changes. An intuitive way to translate cardiovascular risk is to present a Heart Age; an ECG-based age-estimation from ECG changes which can be contrasted to a patient’s chronological age. In this pilot study, the feasibility of a randomized controlled study (RCT) in which hypertensive patients in primary care will receive information about their ECG-based Heart Age in addition to standard care, or standard care alone, will be assessed, in preparation for a larger RCT. |
THOMAS LINDOW; | 2023-04-01 |
| 370 | Targeting The Brain-heart Axis With TMS Among Reproductive Aged Women With PTSD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this randomized clinical trial, we will test the short and longer term effects of repetitive transcranial magnetic stimulation (TMS) on blood pressure among reproductive aged female participants with elevated symptoms of post-traumatic stress disorder and hypertension. |
MARGARET BUBLITZ; | 2023-04-01 |
| 371 | Observational Study on Cardiac Biomarkers Testing in Patients With Muscular Dystrophy Cardiomyopathy and Assessing The Feasibility of Serial Cardiac Troponin Testing at 0 Hour and 1 Hour, As Well As The Mid-term Biovariability of Cardiac Troponin PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate acute changes of cardiac troponin (and other cardiac biomarkers) and mid-term biovariability in patients with cardiomyopathy associated with chronic skeletal muscle disease. The specific aims of the study are: Firstly, to evaluate the feasibility of the ESC 0/1 hour protocol for rule-in and rule-out of a non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Secondly, a) to determine reference change values (RCV) to characterize physiological biovariability, b) to differentiate acute from chronic high-sensitivity cardiac troponin T (hs-cTnT) elevations. |
MUSTAFA YILDIRIM; | 2023-04-01 |
| 372 | Outcomes of Transcatheter Cardiac Interventions in Neonates With Congenital Heart Disease at Sohag University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is performed to assess the safety, efficacy and outcome of transcatheter cardiac interventions in neonates with critical congenital heart disease at Sohag University Hospital |
SOMIA SABRY MAHMOUD; | 2023-04-01 |
| 373 | Long Term Cardiovascular Disease Event Risk for Patients Undergoing Major Non-Cardiac PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn whether the healthy lifestyle choices made around surgery can influence an individual’s long term risk of developing cardiovascular disease. Patients will be observed 1-month prior to and 3-months following surgery to assess their risk of developing cardiovascular disease. |
WILTON VAN KLEI; | 2023-04-01 |
| 374 | Improving Physical Activity and Cardiac Rehabilitation Attendance Using Technology and Behavioral Economics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to test the feasibility of using behavioral economic interventions (gamification with and without loss-framed financial incentives) targeting daily steps counts to improve cardiac rehabilitation attendance. |
SRINATH ADUSUMALLI; | 2023-04-01 |
| 375 | Prospective Measurement of Impedance During Cardiac Catheterization to Build A Non-Invasive Cardiac Output Algorithm PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospectively measure impedance during cardiac catheterization to build a cardiac output algorithm. |
DANIELLE GOTTLIEB SEN; | 2023-03-30 |
| 376 | Safety and Engagement in Cardiac Rehabilitation With The RecoveryPlus Telerehabilitation Platform: A Prospective, Single-arm, Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this prospective, single-arm study, we will look at the initiation, participation, sustained engagement, and safety of 100 adult subjects (ages 45 years or older) with recent (within the past 60 days) clinician referral to CR who are offered CTR via the RecoveryPlus platform. We want to understand the effectiveness of the RecoveryPlus platform in engaging participants in CR while remaining a safe alternative for the delivery of evidence-based CR content. The primary hypothesis of this study is that the RecoveryPlus CTR platform and patient-facing mobile application provide a safe alternative to traditional in-person CR, … |
NITIN G VASWANI; | 2023-03-27 |
| 377 | Effect of Heart-Protecting Musk Pill on Diabetic Microangiopaemia in Type 2 Diabetes Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study mainly investigates the therapeutic effect of Heart-Protecting Musk Pill (HMP) on patients with diabetic microangiopathy. According to the indicators of diabetic nephropathy (DN), diabetic retinopathy (DR), oxidative stress and inflammatory factor in patients with diabetic microvascular disease after using HMP, the investigators aim to evaluate the effect of HMP on diabetic microangiopathy, oxidative stress and inflammation. |
AFFILIATED HOSPITAL OF NANTONG UNIVERSITY | 2023-03-20 |
| 378 | Mind The Heart – Mental Health in Children and Adolescents With Congenital Heart Defects in Denmark PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the Mind the Heart study is to document the feasibility of an online parent/child administered screening model for mental disorders (MDs) in Danish children and adolescents with congenital heart disease (CHD). As MDs in children and adolescents with chronic somatic health issues are frequently underdiagnosed and undertreated, we further aim to develop a website with evidence based information on mental health in children and adolescents with CHD in order to promote knowledge and awareness among families and health professionals across sectors. |
SARA HIRANI LAU-JENSEN; | 2023-03-17 |
| 379 | High Risk Population of Cardiovascular Disease in Hubei Province (Coronary Heart Disease With Diabetes) Screening and Intervention Program PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: High Risk Population of Cardiovascular Disease in Hubei Province (Coronary Heart Disease With Diabetes) Screening and Intervention Program（CCDInT）is a randomized controlled study to verify that protocol treatment group is more effective than the conventional treatment group in reducing the incidence of composite cardiovascular disease (cardiovascular death, non fatal myocardial infarction, non fatal stroke, hospitalization for heart failure, and readmission for acute coronary syndrome) in patients with coronary heart disease and type 2 diabetes. |
WUHAN UNION HOSPITAL CHINA | 2023-03-15 |
| 380 | China Elderly Comorbidity Medical Database PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this observational cohort study is to provide comprehensive evaluation and early warning for elderly patients with chronic diseases. The main question it aims to answer is: How to explore effective evaluation methods for diseases in elderly patients based on the coexistence of multiple diseases and high individual heterogeneity? How to explore the key indicators and influencing factors of adverse events in elderly patients.. Participants will be followed up at 1, 3, 6, 9, and 12 months to obtain adverse event information. |
HONGWEI LI; | 2023-03-01 |
| 381 | Effect of The Screenning With Coronary Computed Tomography Angiography on Lipid-lowering Treatment Adherence and Risk Factor Control in An Asymptomatic Chinese Population: A Community-based, Prospective Randomised Controlled Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot-study of the Role of Screening With Coronary Computed Tomography Angiography in Primary Prevention of Coronary Heart Disease (RESPECT [NCT05431309]) trial. The primary objective of this study is to determine whether coronary computed tomography angiography (CCTA) -based coronary heart disease(CHD) prevention strategy improves lipid-lowering treatment adherence and risk factor control compared with traditional CHD prevention strategy, guided by a cardiovascular risk score. |
ZHANG LONGJIANG; | 2023-03-01 |
| 382 | Multicenter Registry on Robotically Assisted Percutaneous Coronary Interventions – TESLA Registry PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: MulTicenter rEgiStry on RoboticalLy Assisted percutaneous coronary interventions- TESLA registry is a retrospective registry evaluating the safety and efficacy of robotically assisted PCI with the CorPath GRX System (Corindus Vascular, Siemens Healthineers, Germany) in real-world interventional cardiology practice. |
DARIUSZ DUDEK; | 2023-03-01 |
| 383 | Association of Triglyceride-glucose Index With Cardiac Hemodynamics and Cardiovascular Risk Assesment in Obese Patient PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1) To estimate the prevelance of IR in obese patients based on TYG index . 2) To screen early cardiovascular abnormalities in obese asymptomatic patients using conventional echocardiography and electrocardiogram . 3) To detect association of cardiovascular hemodynamics with TyG index . Assess cardiovascular risk in obese patients . |
MICHAEL HANY; | 2023-03-01 |
| 384 | Impact of Fast Gantry Rotation Cardiac CT Angiography on Coronary Motion Artifacts in The Absence of Β-Blocker Premedication in Patients Undergoing Aortic Stenosis Workup: A Single-centre Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the clinical value of a novel CT gantry supporting a .23 second rotation time and systematically compare it with 0.23 second rotation time, in patients with clinically indicated aortic CTA in the workup of aortic stenosis. Patients will be randomly assigned .23 or .28 sec rotation time CTA. Coronary artery interpretability rates will be determined in both groups. |
DAVID C. ROTZINGER; | 2023-03-01 |
| 385 | Rate Control Efficacy in Atrial Fibrillation With Rheumatic Mitral Stenosis: Assessing Clinical Outcomes of Lenient Versus Strict Heart Rate Control in Reducing Hospitalizations, Improving Quality of Life, and Enhancing Functional Capacity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if different types of heart rate control work to improve the clinical outcomes of patients with atrial fibrillation related to rheumatic mitral stenosis in terms of reducing hospitalizations, improving quality of life, and enhancing physical functional capacities. The two types of heart rate (HR) control are strict (resting HR of 60-80 bpm) versus lenient (resting HR of 81-110 bpm) rate control strategies. The main questions it aims to answer are: – Can lenient versus strict heart rate control reduce rehospitalization in patients with atrial fibrillation and rheumatic mitral stenosis? – … |
ARDIAN RIZAL; | 2023-03-01 |
| 386 | Effectiveness of A Cardiac Rehabilitation Program on Biomechanical, Imaging, and Physiological Biomarkers in Elderly Patients With Heart Failure PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to assess the effectiveness of a cardiac rehabilitation program on functionality, measured by kinematic analysis, cardiorespiratory capacity, and ventricular ejection fraction in elderly patients with heart failure (HF). Other objectives will be; 1) to validate the kinematic analysis as an objective functional assessment that allows performing a functional stratification based on the severity of impairment (kinematic phenotypes), as well as to identify those patients who responders or are not responders to the cardiac rehabilitation program; 2) to develop a functional index that includes objective functional parameters, … |
ANTONIO I CUESTA-VARGAS; | 2023-03-01 |
| 387 | The Outcome of Percutaneous Balloon Pulmonary Valvuloplasty in Pediatrics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: evaluation the outcome of percutaneous balloon pulmonary valvuloplasty in children with valvular pulmonary stenosis at the Pediatric Cardiology Unit. |
MOHAMMED TAREK MOHAMMED HAFEZ; | 2023-03-01 |
| 388 | Comparison of Hemodynamic Performance of Transcatheter Aortic Valve Replacement With Supra-Annular Self-Expanding Versus Balloon-Expandable Valves Assessed By Exercise Cardiovascular Magnetic Resonance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The hypothesis is that SEV result in superior valvular hemodynamics (more pronounced during exercise) and exercise capacity relative to BEV. Furthermore, the hypothesis is that stress CMR will be able to demonstrate differences in these hemodynamic parameters. CMR will also provide refined assessment of paravalvular leak and its impact on ventricular function and on clinical outcomes. |
GUILHERME ATTIZZANI; | 2023-03-01 |
| 389 | Effects of Pre-operative Exercise Therapy on Postoperative Outcomes in Children With Corrective Cardiac Surgeries PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effects of preoperative exercise therapy on postoperative cardiopulmonary outcomes and quality of life in children with corrective cardiac surgeries.Within literature there is limited evidence on preoperative exercise therapy in the pediatric population, positive results of the study can introduce a new tradition of preoperative exercise therapy and significantly reduce post-operative complications. Secondary complications would also be addressed in the study, a positive result can reduce the total costs by reducing hospital stays and improving the quality of life of child. |
MEHWISH WASEEM; | 2023-03-01 |
| 390 | The Cardio-protective Effect of Cardiomyopeptidin on Myocardial Injury in ICU Patients With Non-organic Heart Disease: A Prospective, Single-blind, Randomized Controlled Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study was a single-center, randomized controlled pilot study. To explore the cardioprotective effect of cardiopeptidin on non-heart disease patients with severe cardiac injury by comparing whether cardiopeptidin was used. |
ZHENHUA ZENG; | 2023-02-27 |
| 391 | A Randomized Controlled Trial of Rivaroxaban Combined With Dual Antiplatelet Therapy Versus Dual Antiplatelet Therapy Alone 1 Month After Drug-coated Balloon Angioplasty in Patients With Acute Coronary Syndrome Without High Bleeding Risk PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The target population of this interventional study was ACS patients with drug-coated balloons. The main discussion : 1.1 months of rivaroxaban combined with dual antiplatelet therapy compared with dual antiplatelet therapy alone, late lumen loss at 6 months. 2. To determine the safety of the regimen with bleeding events as the end point. Subjects were randomly assigned to two groups, one receiving routine DAPT for six months and one receiving DAPT plus one month of rivaroxaban 2.5 mg bid |
HENAN INSTITUTE OF CARDIOVASCULAR EPIDEMIOLOGY | 2023-02-20 |
| 392 | Comparison of Drug-coated Balloon and Drug-eluting Stent for Severe Calcification of De Novo Lesion in Elderly Coronary Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial was to compare the effectiveness of drug balloons versus drug-coated stents in calcified lesions in elderly coronary artery disease. The main question it aims to answer is whether the application of DCB is non-inferior to DES for in situ large vessel calcified lesions in the elderly coronary arteries. And to develop a method to precisely identify the nature and extent of calcified lesions and to rationalize the choice of pretreatment. |
HENAN INSTITUTE OF CARDIOVASCULAR EPIDEMIOLOGY | 2023-02-20 |
| 393 | The Effect of Brief Versus Individually Tailored Dietary Advice on Change in Lipids, Blood Pressure, and Diet in Patients With Inflammatory Joint Disease The Diet Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized controlled study comparing brief dietary intervention with a personal, tailored dietary advice (60 min) on change in LDL-c and change in diet. |
DIAKONHJEMMET HOSPITAL | 2023-02-20 |
| 394 | Impact of Lactobacillus Plantarum 299v Probiotic Supplementation on Vascular Function and Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to determine the impact of 12 weeks of Lp299v supplementation (20 million cfu/day vs. placebo) on exercise capacity, circulating biomarkers of cardiac remodeling, quality of life, and vascular endothelial function in humans with heart failure and reduced ejection fraction (HFrEF) who have evidence of residual inflammation based on an elevated C-reactive protein level. This will be done in the setting of a randomized, double-blind, placebo-controlled trial. |
MICHAEL E. WIDLANSKY; | 2023-02-20 |
| 395 | FAPO-X: Assisted Digital Telemonitoring With Wearables in Patients After Cardiovascular Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to develop a digitally assisted telemonitoring platform using the Samsung TM Galaxy Watch5 smartwatch, validating the applicability of the solution in patients with POAF (Postoperative Atrial Fibrillation), … |
FABIO BISCEGLI JATENE; | 2023-02-17 |
| 396 | Functional ComprEhensive AssessmenT By Intravascular UltrasoUnd Reconstruction in Patients With Suspected IschEmic Coronary Artery Disease (FEATURE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigating the diagnostic accuracy of online Ultrasonic Flow Ratio (UFR) assessment to identify hemodynamically significant coronary stenosis in patients with suspected ischemic heart disease using angiography-derived fractional flow reserve (FFR) as a reference standard. |
FENGHUA DING; | 2023-02-17 |
| 397 | Understanding Patterns of Deprescribing Antithrombotic Medication During End-of-Life Care in Cancer Patients Across The European Union PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite the fact that antithrombotic therapy (ATT) has little or even negative effects on the well-being of cancer patients during their last year of life, stopping ATT is rare in clinical practice. In contrast, ATT is often continued until death, resulting in excess bleeding, higher healthcare costs, and increased disease burden. SERENITY aims to develop an information-driven, palliative care shared decision-making process enabled by a user-friendly, easily accessible, … |
STAVROS KONSTANTINIDES; | 2023-02-15 |
| 398 | An Open-label, Randomized, Single-dose, 2-way Crossover Study to Establish Bioequivalence of 1 × 15-mg Mavacamten Capsule to 3 × 5-mg Mavacamten Capsules in Healthy Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the effect between two different single doses of mavamten in healthy participants. |
BRISTOL MYERS SQUIBB | 2023-02-15 |
| 399 | Circuit Weight Versus Aerobic Training on Selected Cardiovascular Indices and Functional Capacity in Patients With Ischemic Cardiomyopathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare between the effect of circuit weight and aerobic training on selected cardiovascular indices and functional capacity in patients with ischemic cardiomyopathy. |
SAMIRA SHUKREY SHAFFIK ESHAK; | 2023-02-15 |
| 400 | Single-center Evaluation of Sleepiz One+ in Measuring Respiration Rate and Heart Rate Compared to Gold Standard PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: EtCO2, or exhaled carbon dioxide, is a non-invasive and commonly used measure for respiratory rate and function. It can be easily monitored using a device called a capnograph, which consists of a sensor that is placed near the patient’s mouth or nose and a monitor that displays the concentration of carbon dioxide in the respiratory gases in real-time. EtCO2 capnography is generally considered a reliable and accurate method for monitoring respiration and is often used as a gold standard for comparing the performance of other methods for measuring respiration. Therefore, … |
SLEEPIZ AG | 2023-02-13 |
| 401 | Theophylline Effects in The Fontan Circulation (THIEF Pilot Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A single group treatment phase 2 single-arm no-masking study to assess safety and efficacy of a short-term oral treatment with theophylline (ATC-no. R03D A04) in terms of improvements in cardiorespiratory fitness, health-related quality of life, cardiac performance and respiratory function in male and female adolescents aged 16 to 25 years with a Fontan-type surgical palliation of univentricular congenital heart disease. |
THOMAS MÖLLER; | 2023-02-09 |
| 402 | The Effects of Menaquinone-7 Supplementation in Patients With Severe Coronary Calcifications PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Abstract Introduction Coronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction and cardiovascular mortality. A substudy in the recent Danish study, AVADEC, suggested a protective role of supplementation with vitamin K2 and D in the development of CAC. This finding should be interpreted with caution, but the perspective is very interesting. In this study, … |
AXEL DIEDERICHSEN; | 2023-02-08 |
| 403 | An Open-label Clinical Trial to Evaluate The Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan in Adult Patients With Chronic Heart Failure With Reduced Ejection Fraction Associated With Congenital Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The treatment of adult patients with congenital heart disease (ACHD) and heart failure (HF) represents a great challenge since, to date, there is no standardized guideline for this specific population. Although new treatments for HF have been proposed, such as Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors and neprilisin and angiotensin receptor inhibitors, the benefit of these drugs in patients with HF associated with congenital heart disease in adults has not yet been demonstrated. For this reason, this study pretends to evaluate the efficacy of empagliflozin and sacubitril/valsartan in this population. |
EDGAR GARCIA-CRUZ; | 2023-02-06 |
| 404 | A Randomized-controlled Trial Evaluating A Digital Care Solution (Sidekick, SK-121) for Coronary Artery Disease Patients at Landspítali University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center, randomized clinical trial (RCT), recruiting 200 patients with coronary artery disease (CAD) who are currently receiving standard care treatment at the cardiology department of Landspítali University Hospital in Reykjavik, … |
DAVID O ARNAR; | 2023-02-06 |
| 405 | Safety and Feasibility of Autologous Induced Pluripotent Stem Cells of Cardiac Lineage in Subjects With Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test the safety of lab-grown heart cells made from stem cells in subjects with congenital heart disease. The main questions it aims to answer are: * Is this product safe to deliver to humans * Is the conduct of this trial feasible Participants will be asked to: * Agree to testing and monitoring before and after product administration * Receive investigational product * Agree to lifelong follow-up Researchers will compare subjects from the same pool to see if there is a difference between treated and untreated subjects. |
REBECCA K AMEDURI; | 2023-02-03 |
| 406 | Reexamining Her Cardiovascular Risk – Ottawa WomeN’s Longitudinal Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary revascularization, stroke, total and cardiovascular mortality). This future study will be the first longitudinal cohort study, to our knowledge, that is focused entirely on researching the pathophysiology and natural history of cardiovascular disease in women with known female-specific risk factors. Further, … |
OTTAWA HEART INSTITUTE RESEARCH | 2023-02-01 |
| 407 | Integrated Silicon Photonics for Cardiovascular Disease Monitoring InSiDe-CC Clinical Validation of The Diagnostic Device (LDV) for The Measurement of Heart-carotid Pulse Wave Velocity (PWV) By Magnetic Resonance Imaging (MRI) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Aortic stiffness is an important imaging biomarker of vascular aging. The ascending aorta is the most elastic segment, and it is excluded by reference non-invasive method carotid to femoral pulse wave velocity (PWV). We propose to use laser-doppler vibrometry (LDV) to record superficial vibrations generated by cardiac activity and arterial pulses for measuring heart carotid PWV, a surrogate for ascending aorta. The trial aims to demonstrate the equivalence between heart-carotid PWV made by laser-doppler vibrometry (LDV) with the reference MRI measurement (4D-FLOW MRI). As secondary objectives, A) we aim to assess the reproducibility of LDV, compared with MRI, … |
PIERRE BOUTOUYRIE; | 2023-02-01 |
| 408 | Clinical Usefulness of Virtual Antiarrhythmic Drug Test in Patients With Recurred AF After Catheter Ablation(CUVIA-AF3) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Catheter ablation for atrial fibrillation (AF) is an effective rhythm control method that shows superior rhythm outcome than antiarrhythmic drug (AAD) treatment in drug-resistant AF. However, AF catheter ablation still has a substantial recurrence rate. The current AAD use guidelines for AF management focus on the safety of drug use. However, if the AAD efficacy evaluation system using computer modeling reflecting the individual anatomy, electrophysiology, and histological characteristics of patients is practical, … |
YONSEI UNIVERSITY | 2023-02-01 |
| 409 | Evaluation Par Gating Respiratoire 4D Vs Scanner 3D De La Dosimétrie Cardiaque Chez Des Patientes Traitées Pour Un Cancer Du Sein Gauche PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To establish if the cardiac radiation dose assesment is well aproximated with routine 3D CT scan compared to 4D CT experimental scan with respiratory gating (breath motion monitoring). The study population relates to left side breast cancers female patients that require a radiation therapy treatment. |
CENTRAL HOSPITAL SAINT QUENTIN | 2023-02-01 |
| 410 | Microcirculation and Vascular Function After Fontan Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fontan Surgery is done for children with only one working lower chamber of the heart called the ‘Single Ventricle’. This surgery involves making connections between the two big veins that drain oxygen deficient blood to the heart and the lung artery directly. Fontan patients may develop long-term complications such as reduced heart function or oxygen levels, increased pressure in the veins, … |
IAIN SQUIRE; | 2023-02-01 |
| 411 | The Effect of Lavender Inhalation on Sleep Quality in Individuals With Coronary Heart Disease: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is planned to be conducted as a two-group randomized controlled trial to determine the effect of lavender inhalation on individuals with coronary heart disease. Research data will be collected at Çukurova University Medical Faculty Balcalı Hospital Cardiology Clinic between January-June 2023. In the study, at least 56 samples were found to be sufficient for the sample size. The data of the study will be collected using the Personal Information Form and the Pittsburg Sleep Quality Index. |
SEVGI DENIZ DOGAN; | 2023-02-01 |
| 412 | Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients (ASSERT-AF) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with heart failure (HF) represent a large population of patients who are at high risk for complications related to undiagnosed atrial fibrillation (AF). However, currently there are limited modalities for early AF detection and subsequent stroke prevention in this high-risk population. An implantable cardiac monitor (ICM) is inserted subcutaneously and can provide long term arrhythmia information via remote monitoring. The ASSERT-AF study seeks to accurately define the burden of AF and other arrhythmias in high-risk HF patients using an ASSERT ICM. |
ILAN GOLDENBERG; | 2023-01-31 |
| 413 | De-Adoption Βeta-Blockers in Patients With Stable Ischemic Heart Disease Without REduced LV Ejection Fraction, Ongoing Ischemia, or Arrhythmias: A PragmaTic RandomizEd Trial With Blinded Endpoints PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with heart disease are often prescribed many medications and these patients may experience drug interactions or negative drug related side effects. With newer medications and treatments available, it is not well known whether older drugs, such as beta-blockers, are still an effective and safe option for treating heart disease. Some evidence suggests beta-blockers should be continued, whereas other evidence suggests beta-blockers might cause unnecessary harm. The study hopes to determine whether continuation or discontinuation of beta-blockers will affect long term cardiovascular outcomes. The study investigators will also examine how beta-blockers continuation or discontinuation affects several quality of life measures. |
SEAN VAN DIEPEN; | 2023-01-30 |
| 414 | A Prospective, Single-arm, Multi-center, Feasibility First-in-human Study to Evaluate Safety and Performance of The SirPlux Duo™ Dual-API Coated PTCA Balloon Catheter to Treat De-novo Lesions in Patients With Symptomatic Stable Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective, single-arm, multi-center, safety and feasibility first-in-human study will evaluate the safety and feasibility of the SirPlux™ Duo Dual-API Coated PTCA Balloon Catheter to treat de-novo lesions between ≥2.25 and ≤4.0 mm in patients with stable symptomatic coronary artery disease. |
ADVANCED NANOTHERAPIES | 2023-01-30 |
| 415 | Resolving Unsolved Rare Diseases : Functional Tests and New Diagnosis Strategy to Study Genetic Variants From High-throughput Sequencing (RID) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rares diseases are a heterogeneous group of conditions which need important tools for diagnosis. The use of high-throughput sequencing is able to diagnose half of the patients. For the other part it is impossible to conclude due to the presence of variants of unknown significance (VOUS). Functional analysis are needed to bring strong argument to reclassify variants as pathogenic or benign. The main objective is to evaluate the diagnosis yield of this strategy. |
VINCENT MICHAUD; | 2023-01-30 |
| 416 | Progression of The Ascending Aorta Diameter After Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement in Patients With Bicuspid Aortic Valve PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this prospective, non-randomized, single-center, observational study is to assess whether there is a progressive dilation of ascending aorta after surgical or transcatheter aortic valve replacement (TAVR) in patients who underwent elective aortic valve replacement or TAVR for stenotic bicuspid aortic valve (BAV) at our institution from 2015 to June 2022. Participants will undergo both a CT and an echocardiographic assessment at least 90 days after surgery. |
GIOVANNI A CHIARIELLO; | 2023-01-20 |
| 417 | Evaluation of Long Coronary Artery Stents With Third-generation Dual-source Computed Tomography Angiography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess third-generation dual-source coronary computed tomography angiography (CCTA) performance in the evaluation of long coronary stents in patients with coronary artery chronic total occlusions. The main questions it aims to answer are: – Can patency of long coronary artery stents be assessed with third generation CCTA? – What are the factors affecting the assessability? – What is the radiation exposure of third generation CCTA? |
LAURI MANSIKKANIEMI; | 2023-01-16 |
| 418 | Determination of The Relationship Between Red Cell Distribution Width, NT-proBNP and CTnT in Acute Myocardial Infarction Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the study is to investigate the relationship of several parameters of complete blood count (CBC) including RDW with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in a cohort of acute myocardial infarction (AMI) patients. |
HEMAT KAMEL MAAROUF; | 2023-01-15 |
| 419 | The Effects of 8 Weeks Post Exercise Hot Water Immersion on Vascular and Cardiometabolic Health in Physically Inactive Middle-aged Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research project aims to determine whether post exercise hot water immersion can improve vascular and cardiometabolic health to a greater extent than post exercise thermoneutral water immersion in healthy middle-aged adults. The study will take place over an 8 week period where participants will do a combination of aerobic exercise and water immersion 3 times per week. The study will be a randomised controlled trial comparing 8-weeks of post exercise hot water immersion (EX+HWI) to post exercise thermoneutral water immersion (EX+TNWI). |
CHARLES STEWARD; | 2023-01-13 |
| 420 | Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes: THE STENO INTEN-CT STUDY PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators intend to perform a landmark study to answer whether a combined CVD screening and treatment strategy is beneficial for patients with type 2 diabetes (T2DM) without known cardiovascular disease (CVD) The investigators aim to answer the following main research questions: Do screening detected high-risk patients benefit of intensified medical treatment? Is it safe to de-intensify medical treatment among patients with a screening detected low risk of CVD? Does a CVD screening and treatment program improve patient reported health status? Cardiovascular risk remains high in patients with T2DM but unevenly distributed. Our current risk stratification strategies are far from optimal leading to both under- and over-treatment of patients. In recent years, noninvasive imaging of subclinical coronary artery disease by cardiac CT has improved considerably. This allows for easily accessible evaluations of coronary atherosclerosis burden and composition – exceptionally strong imaging biomarkers of future cardiovascular disease. An increasing amount of data suggests that cardiac CT may permit better risk stratification in patients with T2DM. At the same time, the pharmaceutical treatment of T2DM has changed with several new and expensive drug classes, each individually documented to reduce the risk for new or recurrent cardiovascular events. Thus, these new drugs may improve outcome in high-risk patients, whereas they may be wasteful and only lead to side effects in low-risk patients. In the Inten-CT study, the investigators combine these two pivotal developments. The investigators intend to improve risk stratification of patients with T2DM by use of cardiac CT and, based on this knowledge, the investigators wish to investigate if upgraded medical treatment in the high-risk population is beneficial and if de-intensified treatment in the low-risk population is safe. As a secondary aim, the investigators wish to investigate if such a strategy improves patient reported health status. These aims are in agreement with one of the important health indicators from The Danish College of General Practitioners: We find and treat the patients and let the healthy stay healthy. The investigators intend with this strategy to improve not only cardiovascular outcome among patients with T2DM, but also their quality of life. The Inten-CT study is an investigator-initiated open-label event-driven randomized controlled trial including patients with T2DM stratified according to screen detected coronary artery calcification. The investigators expect inclusion of 7300 patients in 2 years and a mean follow-up period of 5 years. |
PER LØGSTRUP POULSEN; | 2023-01-12 |
| 421 | A Study to Compare The Effects of Sarpogrelate Sustained Release /Aspirin Combination Therapy Versus Aspirin on Blood Viscosity in The Patients With Peripheral Arterial Disease and Coronary Artery Disease; A Prospective, Randomized, Parallel, Open-Label, Single-center, Phase IV Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to compare the effects of sarpogrelate sustained release /aspirin combination therapy versus aspirin on blood viscosity in the patients with peripheral arterial disease and coronary artery disease |
KEUNSANG YUM; | 2023-01-11 |
| 422 | Nutrition In Preoperative Pediatric Congenital Heart Disease: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: The use of a nutritional protocols provides the standardization of assessment procedures and the optimization of nutritional status recovery of pre-surgical infants with Congenital Heart Disease (CHD). However, to our knowledge there are no validated instrument for presurgical nutritional support for infants with congenital heart disease (CHD) in Brazil. Objective: Assess the clinical effectiveness of the translated and cross-culturally adapted protocol, Nutritional Pathway for Infants with Congenital Heart Disease before Surgery (Marino et al., 2018), … |
FERNANDA LUCCHESE; | 2023-01-09 |
| 423 | The Heart Priority Programme for Patients at Risk of Dropout From Cardiac Rehabilitation – A Development- and Feasibility Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to develop The Heart Priority programme, a supplement to standardised cardiac rehabilitation (CR) aimed at identifying and supporting cardiac patients at risk of dropout due to being in a vulnerable situation. Additionally, … |
CHARLOTTE IBSEN; | 2023-01-08 |
| 424 | The Role of Multislice Computed Tomography in Congenital Heart Diseases in Paediatric Age Group PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the added value of cardiac multislice Computed Tomography in assessment of CHD in pediatrics as a non-invasive presurgical planning method |
MOHAMED AHMED ABDELGHANY ELSHERIF; | 2023-01-03 |
| 425 | London Valvular Heart Disease and Reduced Ejection Fraction Detection in A Multi-ethnic Community Using Cardiac Ultrasound PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart Valve Disease and Heart failure contribute to 25% of hospital emergency admissions while heart failure alone has become one of the most common causes for hospitalisation in people over the age of 65. The burden of disease is likely to be high in a multi-ethnic community but there is a paucity of data. Management of heart valve disease requires appropriate surveillance and timely surgery. Similarly heart failure management requires treatment with medications aimed at slowing prevention of symptoms and preventing premature death. The NHS long term plan priorities early detection and treatment of valve disease and heart failure in order to reduce the burden on emergency services and improve the health of the population. Diagnosis is made using cardiac ultrasound, however staff with the required skills-set are critically limited in the community. The investigators will train non-expert staff within primary care to perform abbreviated cardiac ultrasound to detect heart valve disease or heart failure. This will be opportunistic scanning to reduce healthcare footfall. All scans will be reviewed by an expert and the investigators will use the anonymised data to develop machine learning tools to begin working with academic partners to develop tools that can improve the reliability of diagnosis from ultrasound. The investigators hope to identify the proportion with the above conditions in a multi-ethnic community and assess the feasibility of developing a program where staff can be trained for community detection, streamlined referrals can be created bridging the gap between primary and secondary care, reducing hospital emergency admissions, while ensuring patients are managed optimally. |
GUY LLOYD; | 2023-01-01 |
| 426 | Long-term Follow-up of A Randomized Comparison of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Surgery in Unprotected Left Main Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a long-term follow-up of a completed clinical trial which compared percutaneous coronary intervention (PCI) using sirolimus-eluting stents and coronary artery bypass grafting (CABG) in patients with unprotected left main coronary artery disease. The purpose of the study is to obtain retrospective long-term data on clinical outcome of the study population. |
HEART CENTER LEIPZIG UNIVERSITY HOSPITAL | 2023-01-01 |
| 427 | Adult Congenital Heart Disease International EValuation of The Effectiveness of SGLT2i (ACHIEVE-SGLT2i) Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This real-world, international registry aims to evaluate the current experience with sodium-glucose cotransporter 2 inhibitors (SGLT2i) in adult congenital heart disease (ACHD) patients by investigating the prescription patterns, safety, tolerability, and potential beneficial effects on heart failure-related outcomes. |
ANASTASIA D. EGOROVA; | 2023-01-01 |
| 428 | Mechanism of Cardiac and Cerebral Function Injury in Patients With Coronary Heart Disease Caused By Intraoperative Limb Ischemia-reperfusion and Perioperative Organ Function Protection Strategy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: As a simple auxiliary tool for lower extremity orthopedic surgery, tourniquet can effectively reduce intraoperative bleeding and ensure the clarity of the operative field, effectively shorten the operation time and improve the operation efficiency. The extensive use of tourniquets in lower extremity surgery will not only cause local paralysis, pain and other complications, but also bring about postoperative complications such as large drainage volume and deep vein thrombosis. Recent studies have found that tourniquet induced ischemia-reperfusion injury not only affects the local tissue structure and function of skeletal muscle, but also causes reperfusion injury in distant organs (such as heart, … |
HEBEI MEDICAL UNIVERSITY THIRD HOSPITAL | 2023-01-01 |
| 429 | Valuation of Maternal Fetal Cardiac Structure and Function in Pregnancies With Cardiovascular Disease：a Prospective, Multicenter, Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The First Affiliated Hospital of China Medical University initiated a multi-center study to evaluate the changes of maternal fetal heart structure and function in pregnancies with cardiovascular disease by echocardiography, to explore the impact of cardiovascular disease on maternal fetal heart, so as to provide an important reference for obstetric pregnancy risk stratification and management. |
CHUNYAN MA; | 2023-01-01 |
| 430 | Cardiac Structure and Function in Patients with Cystic Fibrosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these are prognostic markers of heart disease in patients suffering from cystic fibrosis (CF). |
TOR BIERING-SØRENSEN; | 2023-01-01 |
| 431 | Assessing and Promoting Resilience in Patients With Adult Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the feasibility and preliminary efficacy of the Promoting Resilience in Stress Management (PRISM) intervention in patients with adult congenital heart disease. |
JILL STEINER; | 2023-01-01 |
| 432 | Effect Of Non Surgical Therapy On Vitronectin And Fetuin-A Levels In Patients With Periodontitis And Coronary Artery Disease- An Interventional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Periodontitis is a chronic inflammatory disease mainly caused by the oral microbial biofilm. It involves the periodontal supporting tissues mainly features gum inflammation, alveolar bone resorption, periodontal pocket formation, and tooth loosening but also induces various systemic diseases, … |
JAIDEEP MAHENDRA; | 2023-01-01 |
| 433 | Mobile Advanced Multi-Parameter Reporting in Patients Wearing A Novel Device: Utilization During Cardiac Rehabilitation Related Papers Related Patents Related Grants Related Experts View Highlight: Advanced remote multi-parameter reporting during cardiac rehabilitation (MAPS-III). The primary purpose of this observational study is to collect baseline information of cardiac rehabilitation usage in the US for post-myocardial infarction (MI) patients with EF > 35% while wearing the ZOLL AMS device for 30 to 60 days. Secondary data on biometrics, arrhythmias, symptoms, and healthcare utilization will provide additional background information on this population during the early post-MI cardiac rehabilitation period. |
ZOLL MEDICAL | 2023-01-01 |
| 434 | Oxygen-enhanced Magnetic Resonance Imaging (OE-MRI) of The Heart: A Feasibility Study Related Papers Related Patents Related Grants Related Experts View Highlight: This exploratory pilot study aims to set up cardiac oxygen enhanced magnetic resonance imaging (OE-MRI). It will involve 10 healthy volunteers and 10 patients with known coronary artery disease (CAD) having a MRI scan. If positive, this data would be used to power an appropriately sized study assessing the utility of cardiac OE-MRI in CAD and other cardiac pathologies. |
CHRIS MILLER; | 2023-01-01 |
| 435 | Pulmonary Determinants of Cardiorespiratory Fitness in Patients With Fontan Procedure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine and record the patient’s medical information and medical records (patient files, computer records, etc.). Physical examination, echocardiographic, electrocardiographic, laboratory, radiological, etc. evaluations are made during the routine controls of the patients. Within the scope of this study, no attempt will be made on the patients, no additional tests will be performed, or treatment changes will not be made in the patients because they are included in this study. After these records, … |
HALUK TEKERLEK; | 2022-12-26 |
| 436 | Metabolomics, Genomics and Nutrition for Cardiovascular Disease Precision Medicine PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this project is to validate, through high-throughput advanced metabolomics techniques, the nutritional assessment tools to be used in the IMPaCT cohort. At the same time, the ability of metabolomics fingerprints of nutritional patterns to discriminate between patients with and without major cardiovascular disease will be identified. Finally, the modification of these predictions will be evaluated based on the genetic profiles. The main hypothesis holds that the integration of metabolomics, genomic and nutritional information will serve to personalize the approach to cardiovascular disease, both in prevention and treatment, and that these tools, in turn, … |
PILAR BUIL- COSIALES; | 2022-12-19 |
| 437 | Assessing The Impact of Aminophylline in The Reversal of Complete Heart Block Secondary to Inferior Wall MI in Atropine Resistant Patients: An Open Label Non-randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study we will evaluate the rate of reversal of complete heart block with aminophylline in atropine resistant patients with inferior wall myocardial infarction (MI) |
NATIONAL INSTITUTE OF CARDIOVASCULAR DISEASES KARACHI | 2022-12-19 |
| 438 | Colchicine in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure with preserved left ventricular ejection fraction (HFpEF) is a syndrome associated with high morbidity and mortality rates. Systemic low-grade inflammation is acknowledged to be a fundamental pathophysiological mechanism of HFpEF. Interventions targeting inflammatory pathway is understudied in HFpEF. Colchicine is a safe and well tolerated anti-inflammatory drug, which interferes with several steps in the inflammatory process. The drug has been extensively studied in different cardiovascular pathologies except HFpEF. We assume that colchicine decreases inflammation and reduces sST2 levels in HFpEF. |
ANASTASIA SHCHENDRYGINA; | 2022-12-15 |
| 439 | A Double-blind Randomized, Parallel-group Study to Evaluate The Impact of Pre-procedural Intracoronary Nicorandil Injection to PREVENT ReductioN Of DecREased TIMI FLOW in Patients Who Undergoing Percutaneous Coronary Intervention for The Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to determine the effect of intra-coronary administration of nicorandil on the prevention of lowering of coronary blood flow for high-risk plaque lesions defined as the high value of lipid core burden index in patients with coronary artery disease who require stent treatment. |
JUNG-JOON CHA; | 2022-12-14 |
| 440 | A Single Centre, Prospective, Feasibility Study of The IKOs™ Coronary Pressure and Flow Rapid-exchange Microcatheter and IKOr™ Console in Patients With Coronary Heart Disease Undergoing Coronary Physiology Investigations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this investigation is to see if the newly developed iKOs™ microcatheter can safely and accurately measure flow and pressure within the heart arteries of 10 patients undergoing angiogram and pressure wire tests. |
ANTHONY MATHUR; | 2022-12-14 |
| 441 | Feasibility and Preliminary Efficacy of High-intensity Interval Nordic Walking in Patients With Coronary Artery Disease: A Pilot Randomized Clinical Trial (HIIT-NoW) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronary revascularization, such as heart bypass surgery (CABG) and percutaneous coronary intervention (PCI [inserting a stent to open up blood vessels]) improve survival for people with coronary artery disease. Yet, many patients suffer from poor physical and mental health after coronary revascularization. Traditional cardiac rehabilitation involving moderate-to-vigorous intensity continuous training (MICT) improves physical and mental health. However, alternative exercise programs, such as high-intensity interval training (HIIT) and Nordic walking may provide superior benefits. Nordic walking is like Nordic skiing but uses specifically designed poles for walking. Nordic walking involved core, upper and lower body muscles, … |
JENNIFER REED; | 2022-12-09 |
| 442 | A Multicenter, Randomized, Controlled Study to Evaluate The Safety and Efficacy of The Adhesion Prevention Device BAX602 in Preventing The Adhesion Around Great Cardiac Vessels in Pediatric Patients With Congenital Heart Disease Undergoing Re-do Open Heart Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart disease occurs in about 1% of live births and can range from (1) naturally curable conditions that require no treatment to (2) conditions that require multiple immediate operations or refractory severe conditions. In the course of a staged surgical intervention, adhesion formation around the heart and large vessels can occur, and dissection of the adhesion site is required at the time of reoperation. There is a concern that dissection may markedly increase the risk of operation such as prolonged surgical time, cardiovascular injury, and increased blood loss, … |
BAXTER HEALTHCARE | 2022-12-08 |
| 443 | Investigation of The Protective Effects of Cardioplegia Solutions Used in Open Heart Surgery on Myocardial Redox Homeostasis at The Level of Redox System and Antioxidant System Related Papers Related Patents Related Grants Related Experts View Highlight: Cardioplegias are different pharmacokinetic solutions routinely used in cardiac surgery to protect the heart from ischemia and induce arrest. Various cardioplegia solutions (such as Bretschneider, del Nido, blood cardioplegia, crystalloid cardioplegia, St. Thomas) are used in clinical practice. There is no clear scientific data in the literature that demonstrates the superiority of one cardioplegia over the others. The choice of the appropriate cardioplegia depends on the surgeon’s clinical experience and preference. In this study preferred the blood cardioplegia and del Nido cardioplegia, … |
TAMER CEBE; | 2022-12-08 |
| 444 | The Role of Colchicine in Reducing The Rate of Myocardial Reperfusion Injury in Patients With ST-Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention: Study on NLRP3, ASC, Caspase, and Troponin PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the role of colchicine in reducing the rate of myocardial reperfusion injury in patients with ST-elevation myocardial infarction after primary percutaneous coronary intervention. The main questions it aims to answer are: – Does colchicine reduce the rate of myocardial reperfusion injury ? – Does colchicine reduce the concentration of markers of myocardial reperfusion injury (NLRP3, ASC, caspase, and troponin) ? Participants will – … |
BIRRY KARIM; | 2022-12-04 |
| 445 | Safety and Efficacy of Drug Coated Balloon Therapy for Coronary In-stent Restenosis in Patients With Coronary Heart Disease Under The Guidance of QFR (UNIQUE-DCB-II Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In 1970, the first percutaneous balloon coronary angioplasty opened a new chapter of interventional therapy. However, the incidence of intracoronary restenosis was about 30%. Subsequently, bare metal stents and drug-eluting stents (DES) reduced the incidence of in-stent restenosis (ISR) to 5%-10% and it was still a bottleneck treated by percutaneous coronary intervention (PCI). Currently, ISR is mainly treated by balloon angioplasty, stent implantation and coronary artery bypass grafting. In 2014, the guidelines of the European Society of Cardiology recommended that drug balloon therapy (DCB) and new generation DES should be the preferred strategies for ISR treatment. Compared with DES, … |
FEI YE; | 2022-12-01 |
| 446 | Safety and Efficacy of Drug Coated Balloon Therapy for De Novo Lesions in Patients With Coronary Heart Disease Under The Guidance of QFR (UNIQUE-DCB-I Study ) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Since Gruntzig successfully performed percutaneous coronary balloon angioplasty in 1977, percutaneous coronary intervention has developed rapidly. From bare metal stents to drug-eluting stents (DES), the symptoms and prognosis of patients with coronary heart disease (CHD) have been greatly improved. Although DES has reduced the probability of in-stent restenosis (ISR) and thrombosis compared with BMS since its clinical application, it can not completely solve this problem. Even if the new generation of DES requires revascularization, the incidence of ISR is still as high as 5%-10%. DES treatment is associated with delayed endothelial healing, late acquired poor stent adherence and new atherosclerosis, … |
FEI YE; | 2022-12-01 |
| 447 | Balloon Dilatation Catheter for The Dilation of Stenotic Atherosclerotic Lesions in Coronary Artery or Bypass Grafts: Evaluation of Safety and Performance in Everyday Clinical Practice. The INVADER™ Percutaneous Transluminal Coronary Angioplasty (PTCA) Post Market Clinical Follow-up (PMCF) Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present observational study is to collect clinical data on the non-implantable medical device INVADER™ PTCA in the daily use in an unselected population. |
ALVIMEDICA | 2022-12-01 |
| 448 | Prospective, Multi Center, Single Group Target Value Study to Evaluate The Safety and Effectiveness of Endovascular Interventional Device Control System and Supporting Consumables for Coronary Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate the safety and effectiveness of endovascular interventional surgery instrument control system （ALLVAS®robot）and supporting consumables for coronary artery interventional surgery. Participants will will complete coronary intervention surgery with the assistance of robot system（ALLVAS®robot）, and evaluate the effect of the use effect of robots and clinical treatment after surgery |
SHANGHAI OPERATION ROBOT | 2022-12-01 |
| 449 | In-hospital Clinical Outcome of Deferred Stenting Versus Immediate Stenting in The Management of Acute STEMI Presenting With High Thrombus Burden: A Randomized Control Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the in hospital clinical outcomes in terms of efficacy and safety of deferred stenting versus non-deferred stenting in STEMI patients with high thrombus burden undergoing primary percutaneous intervention. |
YOMNA MAHMOUD SHOKRY ABDELREHIM; | 2022-12-01 |
| 450 | The Effect of Foot Reflexology on Pain Severity Associated With Mediastinal Chest Drain Removal in Patients Undergoing Open-Heart Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiovascular diseases (CVDs) remain the leading cause of death worldwide and significantly affect patient quality of life and socioeconomic status. The care of CVD patients in Egypt is very complex and sensitive because of the high incidence and high mortality rate. The burden of CVD and the high prevalence of CVD risk factors in Egypt are alarming. Despite great evidence of adverse clinical impact, the pain remains infrequently assessed and poorly managed in ICU. Pain has serious physical and psychological effects which can impair patient recovery and discharge. Moreover, … |
AFNAN ATTIA IBRAHIM MOHAMED; | 2022-12-01 |
| 451 | Intra-Coronary Administration of MCRcI® (Myo-Cardial Regenerative Cellular Injection) Improves Left Ventricular Function in Patients With Diffuse Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Safety evaluation of Intra-Coronary Administration of MCRcI® stem cells in Patients with Diffuse Coronary Artery Disease. |
FANG Y LEE; | 2022-12-01 |
| 452 | Addiction and Correlation With in Hospital Outcomes of Patients Presenting With Acute Coronary Syndrome Regarding to TIMI Flow and LV Function PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the study aims to 1. identify the effect of addiction on TIMI flow in patients presented with acute coronary syndrome. 2. identify the effect of addiction on outcomes of medical treatment of patients presenting with acute coronary syndrome. 3. identify the relation between addiction and LV function. 4. detect the effect of duration of addiction on myocardial infarction lesion and outcomes of pci. |
MINA AMIR ZAKY HABIB; | 2022-12-01 |
| 453 | Investigation of Adults With Congenital Heart Disease in The Scope of The International Classification of Functioning, Disability, and Health PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart disease (CHD) is one of the common birth defects with a prevalence of approximately 1 in 1000 live births worldwide. While 15% of patients with CHD reached adulthood in the past, this rate is close to 90% today thanks to advancing medicine and technology.As individuals with CHD age, they may be affected by acquired cardiovascular risk factors common in the general population in addition to heart diseases such as arterial hypertension, obesity, and diabetes, increasing the risk of metabolic disease, stroke, and coronary artery disease. In addition to these risk factors, … |
TUĞBA SIYAH; | 2022-12-01 |
| 454 | Polypill Strategy for Evidence-Based Management of Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention in An Underserved Patient Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute coronary syndromes (ACS) represent a major contributor to mortality, morbidity, and healthcare costs. Effective therapies are widely available; however, adherence is low. This contributes to worse patient outcomes and increased risk of morbidity and mortality. The once-daily polypill leverages a population-based strategy that has previously demonstrated efficacy in improving adherence and access to therapy in low-resource settings, making it an innovative approach for improving post-ACS care. This study aims to investigate the utility of a polypill-based strategy for patients with ACS with drug eluting stent (DES) placement. The polypill will consist of a high-intensity statin (rosuvastatin 40 mg daily), … |
AMBARISH PANDEY; | 2022-11-30 |
| 455 | Attention Training Technique in Treatment of Anxiety and Depression in Coronary Heart Disease Patients -a Randomized Controlled Trial With 6 Months Follow-up PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anxiety and depression are associated with work disability, lower participation rate in cardiac rehabilitation and unfavourable life style changes following a coronary heart disease (CHD) event. The prevalence of clinically significant symptoms of depression and anxiety in CHD patients has been estimated to 30-50%. Furthermore, depression and anxiety are associated with a significant increased risk of subsequent major adverse cardiovascular events and mortality in CHD patients. Psychological interventions for anxiety and depression in CHD patients have demonstrated small and uncertain effects of symptoms, and no effect on cardiovascular outcomes. Therefore, … |
VESTRE VIKEN HOSPITAL TRUST | 2022-11-30 |
| 456 | Detection and Quantification of Atrial Fibrillation in High-risk Patients Using A Smartwatch Wearable (Apple Watch) With A Photoplethysmographic Sensor and ECG-functionality PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Randomized Controlled trial to evaluate if continuous heart rate and -rhythm monitoring with a photoplethysmography (PPG) smartwatch wearable (Apple Watch series 5) can detect atrial fibrillation at an early stage in cardiac patients with a known high risk of developing AF (ChadsVasc score ≥ 2 men; ≥3 women; age ≥ 65). In this monocenter, single arm, prospective randomized controlled trial the investigators will enroll 306 patients (153 per arm). An absolute in between-group difference of 8.5% in diagnosing patients with new AF in favor of the interventional group during a six month study period is hypothesized. |
ARTHUR A. M. WILDE; | 2022-11-28 |
| 457 | A Multidomain Intervention Program for Older People With Dementia: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study to assess the feasibility of a multidomain intervention for older people with dementia in nursing homes. Participants will be randomized into two equal groups, to receive either an intensive multidomain intervention (intervention group) or regular health advice (control group). The intervention will include physical, cognitive, and social interventions and management of metabolic and vascular risk factors. We hypothesize that the multidomain intervention will be feasible in Vietnam, and participants who receive the intervention will show improvement in cognitive function, quality of life, behaviors, functional ability, sleep, and in reduction of falls, use of healthcare services, … |
NGUYEN XUAN THANH; | 2022-11-24 |
| 458 | Hematological Abnormalities In Children With Congenital Cyanotic Heart Disease Attending Assiut University Hospitals: A Prospective Hospital- Based Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the aim of the study is to determine Hematological abnormalities in Congenital Cyanotic Heart Disease |
MAHMOUD ABDELSHAKOUR; | 2022-11-20 |
| 459 | Metabolic Syndrome and Its Related Diseases in Healthcare Workers: Incidence, Prevalence, and Risk Factors PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the incidence and prevalence of metabolic syndrome and metabolism-related diseases among healthcare workers, identify potential risk factors for these diseases, evaluate the control status of these conditions, and explore the significance of annual regular check-ups in improving metabolic-related health outcomes. All data for the study subjects are sourced from anonymized continuous records in hospital physical examinations and medical case files. The study does not involve any interventions. Upon obtaining the study data, researchers will use retrospective analysis methods to identify possible associations between risk factors and diseases. |
TENGDA XU; | 2022-11-18 |
| 460 | Effect of Short Term Time Restricted Eating on Innate Immunity in Patients With Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this cross over study is to investigate the effect of short term time restricted eating (TRE) on the innate immune system in patients with a history of myocardial infarction. |
NIELS P. RIKSEN; | 2022-11-17 |
| 461 | Detrmination of The Relationship Between Red Cell Distribution Width ,NT-proBNP and CTnT in Acute Myocardial Infraction Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the study is to investigate the relationship of several parameters of complete blood count (CBC) including RDW with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in a cohort of acute myocardial infarction (AMI) patients. |
HEMAT KAMEL MAAROUF; | 2022-11-13 |
| 462 | Development and Translation of Generator-Produced PET Tracer for Myocardial Perfusion Imaging PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A single center, phase 0/1 clinical imaging study designed to assess the role of [68Ga]Galmydar PET/CT imaging in human subjects. |
PAMELA WOODARD; | 2022-11-11 |
| 463 | Dexamethasone, Olanzapine, Flow-targeted Versus Pressure-targeted Hemodynamic Management, and Low Tidal Volume Ventilation in Patients Undergoing On-pump Cardiac Surgery – A Multifactorial Design Randomized Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Open heart surgery, including coronary artery bypass grafting (CABG) and/or aortic valve replacement (AVR) is associated with a significant risk of mortality. This study is a randomized clinical trial with the purpose of investigating four different interventions on the primary endpoint ‘days alive and outside of hospital within 90 days’. The interventions are: * Dexamethasone vs. placebo administered after induction of anesthesia. * Olanzapine vs. placebo administered prior to anesthesia. * A blood-flow targeted vs. a blod-pressure targeted hemodynamic strategy while the patient is on cardio-pulmonary bypass (CPB) * Low-tidal volume ventilation vs. no ventilation of the lungs while the patient is on CPB |
SEBASTIAN WIBERG; | 2022-11-10 |
| 464 | BE-PHIT: A Behavioral Science-Enhanced PHysician-led Remote Group Exercise InTervention for Women With Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ischemic heart disease is the leading cause of death in the United States and worldwide (Nowbar et al., 2019). Exercise has been shown to be effective in preventing repeat heart attacks, hospitalizations and death among heart attack survivors (Lawler et al., 2011). But, few heart attack survivors — particularly women — get the recommended amount of physical activity (Minges et al., 2017; Gorczyca et al., … |
SIMIN G. LEE; | 2022-11-02 |
| 465 | Multicentered Observational Cohort Study on The Efficacy, Safety and Durability of The UniLine Epoxy-treated Xenopericardial Prosthesis in The Treatment of Isolated Aortic and Mitral Valve Disease (UniLine RetroFit) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Acquired heart diseases continue to remain one of the most common causes of cardiac mortality and morbidity. In Russia, heart valve diseases account for 7 to 25% of all cardiovascular diseases, moreover, they rank third as the cause of heart failure. Prosthetic heart valves commonly used as an effective treatment of acquired valvular heart diseases (AVHD). In the Russian Federation, open surgery treatment of AVHD is performed in more than 40 regions by specialists from 92 healthcare organizations. Surgeries on heart valves, being high-tech care, … |
CLOSED JOINT STOCK COMPANY NEOCOR | 2022-11-01 |
| 466 | Accuracy of Apple Watch to Measure Cardiovascular Indices in Patients With Cardiac Diseases: Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Apple Watch validity to measure the heart rate (HR) and oxygen saturation (Spo2) in healthy subjects has been investigated, but its accuracy and validity for patients with cardiac diseases is still unclear. The HR is an important measure to determine the recommended exercise training intensity and to monitor the training intensity in patients with cardiac diseases. The target exercise training intensity during cardiac rehabilitation is between 40% to 70% of heart rate reserve (HRR). Also, cardiac patients who have hypoxemia are advised to continuously monitor their Spo2. Therefore, … |
ALAA KHUSHHAL; | 2022-11-01 |
| 467 | Prediction of Outcomes in Patients With Chronic Heart Failure Based on Tissue Raman Spectroscopy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic heart failure (CHF) is a syndrome complicating heart disease, the prevalence of which has reached epidemic levels. According to global statistics the most common causes of CHF are coronary heart disease (CHD): 26.5%, arterial hypertension (AH):26.2% . The category of patients with CHD complicated by CHF prevails in clinical practice, requiring an optimized approach to determining prognosis in order to improve the effectiveness of therapy. In the literature, this issue has been studied with the use of general clinical, biochemical, instrumental criteria. Nevertheless, … |
PETR A LEBEDEV; | 2022-11-01 |
| 468 | 10 Years Cardiovascular Risk Score Among Primary Health Care Centre Attendees, Assiut Governorate PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aim to assess cardiovascular risk score among patients of AlHadary primary health care centre in Waldeya, Assiut governorate. And to determine the awareness about cardiovascular risk among these patients as well. |
ASMA AHMED RAFAT NAJEEB; | 2022-11-01 |
| 469 | Problem-Solving Therapy for Patients With Chronic Disease and Poor Mental Well-being in General Practice PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In Denmark the vast majority of patients with chronic ischemic heart disease and/or type 2 diabetes are managed in general practice. 20% of the patients suffer from poor mental health. Problem-solving therapy (PST) is a psychotherapeutic method that is proven effective in adults with poor mental health. PST can be provided in general practice. The main objective of this study is to test effectiveness of providing PST to this group patients. |
UNIVERSITY OF AARHUS | 2022-11-01 |
| 470 | Effect of Endodontic Treatment on Serum High Sensitivity C-reactive Protein and Complete Hemogram Indices in Patients With Cardiovascular Disease With and Without Apical Periodontitis: A Prospective Interventional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary Artery Disease without chronic pulp exposure. |
POSTGRADUATE INSTITUTE OF DENTAL SCIENCES ROHTAK | 2022-11-01 |
| 471 | Evaluation of A Novel Remote Vital Sign Monitor Compared to Traditional Inpatient Monitoring in Cardiac Shunt-Dependent Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We are seeing how well a remote monitoring device that looks like a sticker placed on the chest, under the arm can monitor a child’s vital signs including oxygen levels compared to the way that we usually get these measurements. The goal of this study is to see if the new sticker can be used for monitoring patients with cardiac shunt dependent heart conditions from home once they are discharged home. Participating children will be monitored for 6-72 hours with the new sticker in addition to his/her usual hospital monitors so the new sticker device can be compared to our hospital monitors. |
PAMELA CAROL PETERSEN; | 2022-10-26 |
| 472 | Effects of Exercise Training on Ankle-brachial Index and Quality of Life in Coronary Artery Disease Patients After Stenting PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effects of exercise training on ankle-brachial index and Quality of Life in coronary artery disease patients after stenting. There is a need to develop strategies, not only to prevent restenosis but also to improve patients’ functional status and perception of well-being. In particular, it is not well defined whether exercise training can reduce the restenosis rate and improve the outcome after percutaneous intervention (PCI), and its effects on the Ankle-brachial index are not yet well known. |
MEHWISH WASEEM; | 2022-10-18 |
| 473 | The Effect of Continued Mechanical Ventilation on The Occurrence of Myocardial Ischemia in Patients Undergoing Totally Endoscopic Coronary Artery Bypass Grafting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to examine the influence of mechanical ventilation on the occurrence of myocardial ischemia in patients undergoing endo-CABG. |
ABDULLAH KAYA; | 2022-10-17 |
| 474 | Left Bundle Branch Pacing As Initial Therapy in Patients With Non-ischemic Heart Failure and Left Bundle Branch Block (LIT-HF Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study will recruit 50 symptomatic non-ischemic cardiomyopathy (NICM) patients with left ventricular ejection fraction (LVEF) below 35% and complete left bundle branch block (CLBBB), who have not received complete guideline-directed medical therapy (GDMT). Each patient was randomized to 2 groups, GDMT or left bundle branch pacing combined with GDMT (LBBP+GDMT) as initial therapy and was followed up for 2 phases: 0-6 months (phase I), 7-18 months (phase II). The primary objective is to compare the LVEF change , syncope and malignant ventricular arrhythmias between GDMT group and LBBP+GDMT group, … |
JIANGANG ZOU; | 2022-10-14 |
| 475 | A Prospective, Non-Randomized Pivotal Clinical Investigation to Demonstrate The Safety and Performance of The TrueCross Single-Use Microcatheter PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The trial is a pivotal clinical investigation, which is a prospective, non-randomized pivotal clinical investigation to demonstrate the safety and performance of the TrueCross Single-use Microcatheter. |
INSIGHT LIFETECH | 2022-10-13 |
| 476 | Comparison of The Point-of-care Coagulation Device Quantra With The TEG for Congenital Cardiac Surgery – A Pilot Validation Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Congenital heart surgery on cardio-pulmonary bypass (CPB) is associated with impacted coagulation quality and increased bleeding after separation of CPB. The current testing device used at our institution is the TEG 5000 (Haemonetics Corporation). The novel coagulation testing device Quantra System (Hemosonics) has favorable properties (result within 20 minutes) allowing for a quicker identification of the coagulation problem and hence faster administration of the correct coagulation products, potentially leading to better coagulation quality and possibly reducing the need of additional blood products. The aim of this prospective observational (non-interventional, … |
ALEXANDER SCHMIDT; | 2022-10-13 |
| 477 | Detection of Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors Exposed to Cisplatin-based Chemotherapy and Bone Marrow Transplant PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant |
SUPARNA C. CLASEN; | 2022-10-11 |
| 478 | VRAP-Heart – Virtual Reality Assisted Patient Empowerment for Interventions in Structural Heart Disease – A Randomized-Controlled Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective, randomized-controlled multicenter study investigates whether virtual reality-assisted patient education in patients undergoing transfemoral transcatheter aortic valve implantation (TAVI) can improve patient understanding and simulative orientation, thereby reducing postinterventional complications, resulting in significantly shorter length of stay. |
CHRISTIAN JUNG; | 2022-10-05 |
| 479 | Strategies to Increase Adherence to Physical Activity in A Phase III Cardiac Rehabilitation Program PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study consists of a randomised clinical trial of two parallel groups conducted in patients with ischaemic heart disease after completing phase II of Cardiac Rehabilitation (RHBC) at the Centro de Especialidades Mislata (CEM),Hospital Manises. The objective is to assess adherence to structured and unstructured physical activity in the long term (6 and 12 months). In addition to the usual recommendations in the Control Group (CG), a motivational programme will be added to the Intervention Group (IG), which will consist of establishing an individualised exercise plan reviewed monthly, in addition to maintaining continuous contact with the physiotherapist. |
HOSPITAL DE MANISES | 2022-10-04 |
| 480 | Analyzing The Association Between Cardiovascular Diseases and Mental Illness Considering Environmental Risk Factors PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiovascular diseases (CVD) are important public health concerns around the world and closely associated with the development and progression of mental illness, which in turn increases the risk of developing cardiovascular diseases. This study aimed (1) to explore the known or unknown protective and risk factors underlying this comorbidity using questionnaires; (2) to study the biomarkers (body fluid, imaging) of the participants, and to find the influence on the relationship between CVD and mental health; (3) to identify high-risk populations for mental disorders in CVD patients and to establish prediction models. (4) to establish a specialized medical database. |
NINGBO NO 1 HOSPITAL | 2022-10-01 |
| 481 | A Prospective, Multicentric, Randomized Controlled Clinical Trial of Drug-coated Balloons in The Treatment of Big De Novo Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, multicenter, randomized controlled, open-label, non-inferiority trial. Plan to recruit 240 patients whose lesions are de novo coronary artery disease (reference vessel diameter ≥ 3.0 mm), diameter stenosis ≥ 75% with ischemic symptoms or objective evidence of ischemia (ECG, cardionuclide, or FFR), and are suitable for implantation DES or DCB. After successful preconditioning, … |
XUE YU; | 2022-10-01 |
| 482 | Scoring-Balloon Angioplasty and Sirolimus-Eluting Balloon Angioplasty for The Treatment of Diffuse, Small Vessel Coronary Artery Disease (SCA-DEB Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, single-center, single-arm study to evaluate the feasibility and safety of the combination of Scoring-Balloon Angioplasty and Sirolimus-Eluting Balloon Angioplasty for the treatment of diffuse, small vessel coronary artery disease. The objective of the study is to demonstrate the feasibility and safety of the combination of scoring-balloon angioplasty (SBA) plus sirolimus-eluting balloon angioplasty (SEBA) for diffuse (lesion length ≥20 mm), small vessel (diameter 1.5 mm -2.75 mm) coronary disease. |
DOBRIN VASSILEV; | 2022-10-01 |
| 483 | Effect of Multielectrode Versus Point-by-Point Mapping on Recurrence of Ventricular Tachycardia in Ischemic Heart Disease – A Prospective, Randomised Single Centre Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: VT ablation is a frequently performed intervention in patients with symptomatic ventricular tachycardia, electrical storm due to monomorphic VT and appropriate ICD shocks, primarily aiming at reducing the burden of complaints, and ICD shocks. The recommendations for its use were described in the ESC guideline for ventricular arrhythmias and the prevention of sudden cardiac death. To visualize the arrhythmogenic substrate leading to ventricular tachycardia complex mapping techniques are currently used in clinical routine, including conventional Point-by-Point mapping or Multielectrode Mapping. The latter is associated with shorter Mapping and overall procedure times, … |
LEIPZIG HEART INSTITUTE | 2022-10-01 |
| 484 | Relationship of Arterial Stiffness Value With Hemodynamic Parameters in Patients Undergoing Cardiac Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Hypotension during the induction of anesthesia is a significant clinical condition associated with increased perioperative morbidity and mortality. This study aims to evaluate whether hypotension occurring during anesthesia induction can be predicted using arterial stiffness and stiffness index parameters measured by ultrasonography. Additionally, the study investigates potential associations between arterial stiffness parameters and intraoperative hemodynamic variables, vasoactive drug use, length of stay in the hospital and intensive care unit (ICU), and mortality. Methods: This prospective study was conducted in patients scheduled for elective open cardiac surgery. The predictive value of arterial stiffness, measured by ultrasonography, … |
MUSTAFA AYDEMIR; | 2022-10-01 |
| 485 | Validity of SeismoFit VO2max Estimation in Patients With Heart Failure or Ischemic Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Measurement of cardiorespiratory fitness (VO2max) is considered an important tool in risk prediction of cardiovascular disease and overall patient management. The gold standard method for determining VO2max is a maximal cardiopulmonary exercise test (CPET). This requires time, … |
JØRN WULFF HELGE; | 2022-10-01 |
| 486 | Clinical Study Evaluating The Gastroprotective Effect of Carvedilol in Patients With Ischemic Heart Disease on Aspirin Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the possible efficacy of Carvedilol as gastroprotective agent against aspirin-induced upper gastro-intestinal complications in patients with ischemic heart disease (IHD). |
SARAH MOHAMED ELKABLAWY; | 2022-10-01 |
| 487 | Effects of Mindfulness Based Therapy on Patients Perception of Illness and Depression in Cardiac Rehabilitation Phase-i PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomize controlled trial will be conducted at Punjab institute of cardiology hospital Lahore, through convenience sampling technique on 48 patients which will be allocated through simple random sampling through sealed opaque enveloped into group A and Group B. Pretreatment values of patients’ blood pressure, RR, HR, will be recorded. And patient’s perception of illness through Illness Perception Questionnaire (IPQ), … |
WAJEEHA ZIA; | 2022-10-01 |
| 488 | Effect of Ketamine Versus Sevoflurane On The Right Ventricular Pressure During Congenital Pulmonary Stenosis Balloon Dilatation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to compare the effect of different anesthetic drugs used for induction of anesthesia ketamine versus sevoflurane on the RV pressure in pediatrics undergoing balloon dilatation for congenital pulmonary stenosis. |
AMR GABER; | 2022-10-01 |
| 489 | Lymphatic Function in Patients With Fontan Circulation: Effect of Physical Training PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The Fontan operation has been used to treat complex cardiac anomalies with a single-functioning ventricle. A study performed by Instituto do Coracão-Hospital das Clínicas-Universidade de Sao Paulo (InCor/HCFMUSP)-Brazil, Hospital das Clínicas of Ribeirão Preto-Brazil, department of the University of Aarhus, and Rigshospitalet, Denmark demonstrated an impairment peripheral lymphatic function in Fontan patients compared with healthy controls. However, the ability to increase the frequency of contractions is impaired when stressed by hyperthermia. Lymph vessels in Fontan patients were unable to respond usually. The participants were only able to increase the frequency of contraction twice during stress, … |
AIDA LUIZA R TURQUETTO; | 2022-09-26 |
| 490 | Evaluation of Cognitive Status, Kinesiophobia, Physical Activity Level, and Functional Performance in Coronary Intensive Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of our study is to evaluate cognitive status, kinesiophobia, physical activity level, and functional performance in coronary intensive care. |
DILARA SAKLICA; | 2022-09-23 |
| 491 | Evaluation of Respiratory Parameters and Functional Capacity in Coronary Artery Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate respiratory parameters and functional capacity in coronary artery patients. |
DILARA SAKLICA; | 2022-09-23 |
| 492 | Video Laryngoscopy Versus Direct Laryngoscopy for Nasotracheal Intubation in Neonates and Infants With Congenital Heart Disease Less Than 1-year of Age Prior Cardiac Surgery: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to perform a pilot study investigating the first attempt intubation success rate differing between video laryngoscope nasotracheal intubation and direct laryngoscope nasotracheal intubation. The study population will consist of 60 neonates and infants with congenital heart disease less than 1 year of age who need nasotracheal intubation during general anesthesia for cardiac procedures. Standard nasotracheal intubation will be performed using either a video laryngoscope or direct laryngoscopy. Neonates and infants will be randomly assigned (1:1) to standard video laryngoscopy (with one of the following systems: Storz C-MAC Miller Video Laryngoscope, Karl Storz, Tuttlingen, … |
EVA M. BASE; | 2022-09-21 |
| 493 | Association of PeRiODontal Disease and GUt Microbiome With Coronary ArtEry Disease (PRODUCE Study) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to explore the relationship between periodontal disease and coronary artery disease through changes in the gut microbiome. In addition, the investigators aim to find possible periodontal pathogens that have association with cardiovascular disease. |
JONG-WON HA; | 2022-09-20 |
| 494 | Feasibility and Effectiveness of A Real-time Heart Team Approach in Complex Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is aimed to evaluate the feasibility and clinical outcomes of the real-time heart team approach and the conventional heart team approach. |
ZHE ZHENG; | 2022-09-20 |
| 495 | Rethinking Post-acute Cardiac Care: Pilot Randomized Clinical Trial of Live-streamed Cardiovascular Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiovascular Rehabilitation (CR) programs are designed to help people recover following a heart attack, heart surgery, or diagnosis of heart disease. Counseling, education, risk factor management, and efforts to increase levels of MVPA constitute the largest components of CR programs. Technological advances in video-conferencing and video-streaming are affording new opportunities to increase access to CR services and supervised exercise sessions for patients who are social distancing, or who face access issues (e.g., time, mobility, … |
THAIS COUTINHO; | 2022-09-20 |
| 496 | Comparison of Center-Based and Tele Cardiac Rehabilitation on Functional Capacity, Quality of Life, and Fear of Activity in Coronary Artery Disease: A Patient-Preferred, Controlled, Prospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to compare the effects of tele-cardiac rehabilitation (TCR) and hospital-based cardiac rehabilitation (HBCR) on functional capacity (maximum oxygen consumption), fear of activity and quality of life in patients with coronary artery disease. CAD). The rehabilitation program included patient-specific aerobic and peripheral muscle strengthening exercises for four weeks and 3 sessions per week. While the HBCR group performed the exercise program under supervision in the cardiac rehabilitation (CR) unit, the TCR group performed the exercise program at home/outdoors using a Polar H9 heart rate monitor and elastic band. |
LEVENT KARATAŞ; | 2022-09-19 |
| 497 | Determining The Cause of Coronary Vasomotor Disorders in Patients With Ischemia and No Obstructive Coronary Artery Disease PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott Coroventis Coroflow Cardiovascular System, and to determine long-term outcomes. |
SAMIT SHAH; | 2022-09-14 |
| 498 | Feasibility of BIOchemical Urine Analysis of Adherence to Statins and Associated FACTorS in Coronary Artery Disease: The BIO-FACTS Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Feasibilty study of biochemical urine analysis of adherence to high intensity statin therapy in outpatients with coronary artery disease |
MAXIMILLIAN BROCKMEYER; | 2022-09-14 |
| 499 | Reducing Sedentary Time in Patients With Cardiovascular Disease: A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop and test a 12-week sedentary behavior reduction intervention (Sit Less program) for patients with cardiovascular disease. The program aims to reduce and break sitting times among this population using an objective activity monitor and mHealth. The investigators will test the program to help cardiovascular disease patients break up sitting time, reduce daily sitting time, and move more. The investigators will also study whether the program leads to improvements in heart disease risk factors, and whether cardiovascular disease patients like the program and can follow it. |
CHORONG PARK; | 2022-09-13 |
| 500 | Genomic Study of Young-Onset Diabetes Mellitus PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes Mellitus (DM) has been a major contributor to health burden in Indonesia and currently its burden still continues to rise. This is a result of increasing DM prevalence in the country as well as high rates of chronic complications from DM. Findings in Indonesia show that there is a high proportion of young people with diabetes, and also a high risk of therapeutic failure and complications from DM occurring in the younger population. Young-onset DM has a wide clinical spectrum, including autoimmune DM, polygenic DM, … |
DICKY L TAHAPARY; | 2022-09-12 |