Clinical Digest: Recent Clinical Trials on Hepatitis
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Hepatitis. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Hepatitis
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | A Multicenter, Prospective, Real-World Study of Antiviral Therapy in Children With Chronic Hepatitis B PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, prospective, real-world study. The study plans to include a total of 2000 patients who meet the inclusion and exclusion criteria, consisting of 1600 treatment-naive patients and 400 treatment-experienced patients. The effectiveness and safety of different treatment strategies will be evaluated in children aged 1-12 years with treatment-naive and treatment-experienced chronic hepatitis B (CHB) and chronic HBV infection. |
FU-SHENG WANG; | 2025-05-01 |
| 2 | A Multicenter, Prospective, Open-label, Non-inferiority Randomized Controlled Study on The Efficacy of Tenofovir Alafenamide Fumarate Vs. Tenofovir Disoproxil Fumarate in Preventing Mother-to-Child Transmission of Hepatitis B Virus in Pregnant Women With High Viral Loads PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to compare the mother-to-infant transmission rates of hepatitis B between pregnant women receiving treatment with tenofovir alafenamide and those receiving treatment with tenofovir disoproxil fumarate, after administering the hepatitis B vaccine and hepatitis B immunoglobulin to their infants at birth. Investigators define the mother-to-infant transmission rate of hepatitis B as the proportion of infants who are HBsAg positive and have serum HBV DNA \>20 IU/mL at 28 weeks of age among all live births in the experimental group. Additionally, … |
CALVIN Q.PAN; | 2025-05-01 |
| 3 | Methylene Blue Treatment of Chronic Hepatitis B Virus Infection: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: HBV infection is a global public health problem. It is estimated that there are more than 250 million HBV carriers worldwide, of whom approximately 600,000 die each year from HBV-related liver disease. Diagnosis and treatment depend on the stage of infection, the degree of liver inflammation, and the progression of fibrosis. Patients with HBeAg-positive or -negative hepatitis are usually treated with nucleos(-t)ide analogues. This treatment inhibits HBV reverse transcriptase and reduces viral replication, … |
ANDREAS CERNY; | 2025-05-01 |
| 4 | A Phase 1/2, Dose-finding Study Investigating The Safety and Efficacy of Pirtobrutinib in Adults With Immune Thrombocytopenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the phase 1 part of this study is to evaluate how well pirtobrutinib is tolerated and what side effects may occur. The phase 2 part of the study will further investigate efficacy and safety of multiple pirtobrutinib dosages versus placebo. The study drug will be administered orally in participants with Primary Immune Thrombocytopenia (ITP). Blood tests will be performed to check how much pirtobrutinib gets into the bloodstream and how long it takes the body to eliminate it. The study will last up to approximately 16 weeks for phase 1 dose-escalation and 28 weeks for phase 2 dose-optimization, excluding screening. |
ELI LILLY | 2025-05-01 |
| 5 | A Single-arm, Multicenter, Prospective Phase II Clinical Study of Anlotinib Combined With Benmelstobart in The First-line Treatment of Advanced Pheochromocytoma/Paraganglioma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is currently no standard first-line treatment for stage PPGL, and the 5-year survival rate of patients with advanced pheochromocytoma/paraganglioma (PPGL) is low, ranging from 30% to 60%. At present, several domestic teams have carried out clinical studies on the treatment of advanced PPGL with good efficacy. In the early stage, our center used anrotinib to treat advanced PPGL, and the overall effective rate reached 44%. In the early stage, our team used anrotinib combined with PD-1 monoclonal antibody to treat advanced PPGL patients. The effective rate reached 66% (2/3). Therefore, … |
ZHOU FANGJIAN; | 2025-05-01 |
| 6 | Constitutive IL7R (C7R) Modified Banked Allogeneic CD30 Chimeric Antigen Receptor Epstein-Barr Virus-Specific T Lymphocytes (CD30.CAR-EBVSTs) in Patients with Relapsed or Refractory CD30-Positive Lymphomas PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study involves patients that have a cancer called diffuse large B cell lymphoma (DLBCL), Natural killer/T-cell lymphoma (NKTL), or classical Hodgkin lymphoma (cHL) (referred to collectively as lymphoma). Patients’ lymphoma has come back or not gone away after treatment. A previous research study at Baylor combined two ways of fighting disease: antibodies and T cells. Antibodies are proteins that bind to bacteria, viruses and other foreign substances to prevent disease. T-cells are special infection-fighting white blood cells that can kill tumor cells or cells infected with bacteria and viruses. Both have shown promise treating cancer, … |
PREMAL LULLA; | 2025-05-01 |
| 7 | PREVENTION of RECURRENCE of CLOSTRIDIOIDES DIFFICILE COLITIS with URSODEOXYCHOLIC ACID (UCDA) AS A SUPPLEMENT to STANDARD THERAPY PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine whether Ursodeoxycholic Acid (UDCA) can help prevent recurrence of Clostridioides difficile (C. diff) colitis when used along with standard antibiotic treatment. C. diff colitis is a serious infection that can return after treatment, and researchers want to see if UDCA can reduce this risk. This study aims to answer three main questions. First, can UDCA help prevent C. diff from returning after standard treatment? Second, does adding UDCA to treatment lower the need for repeated antibiotic use? Third, … |
DANIEL STEIN; | 2025-05-01 |
| 8 | Efficacy and Safety of Pegylated Interferon Therapy in Chronic Hepatitis B Patients After Discontinuation of Antisense Oligonucleotide or Small Interfering RNA: A Prospective, Adaptive, Open-label, Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare sequential PEG-IFNα therapy strategies in chronic hepatitis B (CHB) patients previously treated with ASO/siRNA. The main questions it aims to answer are: 1. Does sequential PEG-IFNα therapy (vs. deferred/no treatment) improve HBsAg clearance rates? 2. What are the HBsAg clearance and relapse rates after 24 weeks of PEG-IFNα therapy? 3. Is intermittent PEG-IFNα therapy as effective and safe as continuous therapy? Researchers will compare: • Group A (immediate 24-week PEG-IFNα + 24-week follow-up) vs. Group B (24-week observation + 24-week PEG-IFNα) in Phase 1 to see if sequential PEG-IFNα therapy will improve HBsAg loss rate . Researchers will describe: * The response rate of IFN treatment in non-responders (HBsAg-positive) in Phase 2. * The relaspe rate of responders (HBsAg-negative). Participants will: Phase 1 (0-48 weeks): * Group A: Receive PEG-IFNα for 24 weeks, followed by 24-week treatment-free follow-up. * Group B: Undergo 24-week observation, then receive PEG-IFNα for 24 weeks. Phase 2 (48-96 weeks): * HBsAg-positive at week 48 patients either from group A or group B : Receive 24-week PEG-IFNα therapy, followed by 24-week follow-up. * HBsAg-negative at week 48 patients either from group A or group B: Enter 24-week follow-up without treatment. All participants will undergo: • HBsAg quantification, HBV DNA, liver function, and safety monitoring (every 12 weeks). |
WEN-HONG ZHANG; | 2025-05-01 |
| 9 | Clinical Relevance of Drug-drug Interactions (DDI) With The Currently Used Direct-acting Antiviral Therapy (DAA) Against Hepatitis C Virus (HCV) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Currently used direct-acting antivirals (DAA) share pharmacokinetic pathways with many comedications commonly used in patients with chronic hepatitis C virus (HCV) infection, therefore drug-drug interactions (DDI) might exist. Although extensive (DDI) verification is recommended by most clinical practice guidelines, real-world studies have shown that approximately one-tenth of patients on DAA therapy also take concomitant medication with the potential for significant interactions. Despite the risk of significant DDI when patients are administered DAA and a concomitant medication, to date, … |
JUAN MACÍAS; | 2025-04-30 |
| 10 | Terapias Complementares No Processo De Envelhecimento De Pessoas Vivendo Com HIV: Uma Abordagem Multi-design Sobre O Efeito Da Massoterapia, Aromaterapia E Do Exercício Físico PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: PROBLEM DELIMITATION AND JUSTIFICATION Complementary therapies, including physical exercise and massage therapy, are ways to mitigate the side effects of aging, HIV infection and ART. In parallel, there are studies that seek to propose a way to analyze muscle strength and endurance, balance, walking ability, body composition, immunological, metabolic and biochemical parameters, sarcopenia, frailty syndrome, sleep quality, self-perception of health, self-esteem, perception of body image, anxiety, depression, cognitive function, medication adherence, quality of life, diet and level of physical activity in people living with HIV (PLWH). However, the impact of concurrent training, … |
ANDRE PEREIRA DOS SANTOS; | 2025-04-30 |
| 11 | The Epidemic Status and Development Trend of Hepatitis C Virus Infection in Pregnant Women in Xi’an: A 10-Year Retrospective Study PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this study are to improve HCV linkage-to-care in Chinese women and provide theoretical basis for the scientific formulation of HCV prevention and control strategies for pregnant women. To understand the epidemiological changes and status of hepatitis C virus (HCV) infection in pregnant women in Shaanxi province in recent 10 years, and to analyze the main influencing factors of hepatitis C infection in pregnant women. |
HE YINGLI; | 2025-04-25 |
| 12 | An Exploratory Clinical Study Evaluating The Impact of Interferon Consolidation Therapy on Intrahepatic CccDNA Levels in Chronic Hepatitis B Patients Who Achieved Clinical Cure With Peginterferon Α-2b Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, prospective, exploratory clinical study. The study plans to enroll 30 chronic hepatitis B (CHB) patients which achieved HBsAg clearance based peginterferon α-2b treatment. Eligible subjects will receive either 12-24 weeks interferon consolidation therapy (180μg administered subcutaneously in the abdomen or thigh once weekly) or not according to physician’s recommendation and patient’s preference, with regular follow-up for HBV recurrence. Patients will be followed up every 12 weeks. The study will evaluate changes in intrahepatic covalently closed circular DNA (cccDNA) and peripheral blood HBV pregenomic RNA (pgRNA) levels after achieving HBsAg clearance. |
LIANG HUIQING; | 2025-04-20 |
| 13 | Postoperative EGFR-TKI Therapy for High-Risk Synchronous Resectable Contralateral Pulmonary Nodules in Patients With EGFR-Mutant Non-Small Cell Lung Cancer（ARMOR2501） PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background Synchronous multifocal primary lung cancer (sMPLC) presents a therapeutic challenge, particularly for bilateral lesions. While surgical resection is standard for unilateral sMPLC, bilateral surgery carries high perioperative risks. This study evaluates postoperative adjuvant therapy with almonertinib, a third-generation EGFR-TKI, to reduce secondary surgery rates by targeting residual contralateral lesions in EGFR-mutant NSCLC patients. Objective * Primary: Assess the secondary surgery rate within one year after three months of almonertinib therapy. * Secondary: Evaluate tumor response (ORR, EGFR-TKI response rate), survival outcomes (DFS, OS), treatment safety, and surgical feasibility post-therapy. Study Design * Phase: Single-arm, open-label, … |
YANG HONG; | 2025-04-20 |
| 14 | Effect of Long-Term Use of Tenofovir (TDF) on Renal Function in Patients With Chronic Hepatitis B PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Effect of Long-Term Use of Tenofovir (TDF) on Renal Function in Patients with Chronic Hepatitis B Over a Five-Year Period |
NOUR SHAABAN MOHAMED ABD ELRASOUL; | 2025-04-10 |
| 15 | Seven Day Versus Fourteen-day Corticosteroid in Patients With Severe Alcohol -Associated Hepatitis- A Double Blind Randomized Controlled Trail (STASH II) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Alcohol-associated hepatitis (AAH) is one of the most severe manifestations of the spectrum of alcohol related liver disease (ARLD), with high morbidity and mortality. Currently, corticosteroids are the standard of care for patients with severe AAH, but no consensus exists on the dosing schedule of steroids. The investigators have recently demonstrated that tapering prednisolone over 4 weeks reduces the risk of infections at day 90. However, the investigators wanted to test whether the reduction in the duration of therapy would provide a similar benefit as tapering the dose of prednisolone. Therefore, … |
ANAND KULKARNI; | 2025-04-07 |
| 16 | Lymphatic Osteopathic Manipulative Treatment Protocol for Healthy Individuals: A Crossover Self-Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine whether osteopathic manipulative treatment (OMT) enhances immune system readiness in healthy adults compared to exercise or sham light treatment. Specifically, the goal of this study is to assess circulating immune cells and signaling molecules in the blood in response to these various treatments. It aims to compare: Complete Blood Counts (CBC) and blood immune signaling molecule levels in healthy adults in response to OMT, sham light touch, and exercise, … |
BRIAN LOVELESS; | 2025-04-05 |
| 17 | GPC-3 Chimeric Antigen Receptor T Cells for Recurrent GPC-3 Positive Glioblastoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancers. This research study combines two different ways of fighting cancer: antibodies and T cells. Antibodies are types of proteins that protect the body from infectious diseases and possibly cancer. T-cells, also called T lymphocytes, are special infection-fighting blood cells that can kill other cells, including cells infected with viruses and tumor cells. Both antibodies and T cells have been used to treat participants with cancers. They have shown promise, … |
BAYLOR COLLEGE OF MEDICINE | 2025-04-03 |
| 18 | HEPATITIS C SCREENING in ADULTS with RISK FACTORS in FIVE CITIES of COLOMBIA’S CARIBBEAN COAST PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C virus (HCV) infection is a significant cause of chronic hepatitis, cirrhosis, and liver cancer (1). The risk of developing cirrhosis in people with chronic HCV infection ranges between 15% and 30% over a period of 20 years (2). In 2016, the World Health Organization (WHO) defined the global strategy for eliminating viral hepatitis (Hepatitis C and Hepatitis B). The goals for hepatitis C include a 90% reduction in new cases of infection and a 65% reduction in mortality (3). To achieve this target by 2030, 90% of people living with hepatitis C need to be diagnosed, … |
DIANA ROCIO CHAVEZ BEJARANO; | 2025-04-01 |
| 19 | Acceptability and Feasibility of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users and Vulnerable Populations, in Non-conventional Structures Outside The Walls By Dual Screening Method RTDs and FibroScan® PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The Scanvir concept aims to achieve barriers to HCV screening and treating of marginalized patients. The concept is applicable to other various populations and territories and should effectively improve HCV patient’s health outcomes. The main objective of the SCANVIR project was to evaluate the feasibility, acceptability and reproducibility of a test, treat and cure strategy for PWIDs and vulnerable populations during dedicated days in addiction care centers. |
VÉRONQIUE LOUSTAUD-RATTI; | 2025-04-01 |
| 20 | Phase 3, Randomized, Controlled, Open-label Study to Compare The Efficacy and Safety of Bemnifosbuvir-Ruzasvir Fixed-dose Combination (BEM/RZR FDC) Versus Sofosbuvir-Velpatasvir Fixed-dose Combination (SOF/VEL FDC) in Subjects With Chronic Hepatitis C Virus (HCV) Infection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the efficacy and safety of BEM/RZR to SOF/VEL in adults with chronic HCV. |
ATEA PHARMACEUTICALS | 2025-04-01 |
| 21 | Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell Deregulation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Natural Killer (NK) and B cell immune responses occur during the early stages of infection and are essential to eradicate it. Yet, chronic hepatitis B (CHB) infection occurs because the antiviral immune response is insufficient. In both NK and B cell studies we will explore the genetic alterations that occur during the varied chronic stages of the disease. We believe that our findings will allow us to understand the molecular signature of NK and B cells in the context of HBV infection. |
VÉRONQIUE LOUSTAUD-RATTI; | 2025-04-01 |
| 22 | Exploring The Knowledge, Attitudes, Behaviors and Perceived Barriers of Hepatologists Towards Non-invasive Hepatocellular Carcinoma Prediction Models in Hepatitis C Patients Who Achieved Sustained Virological Response Following Direct Acting Antivirals Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the knowledge, attitudes, and behaviors (KAB) of hepatologists regarding different models used to predict hepatocellular carcinoma (HCC) in patients with chronic hepatitis C (HCV) who achieved sustained virological response (SVR) after direct-acting antiviral (DAA) therapy. The study will use a structured questionnaire targeting hepatologists globally to evaluate their familiarity with, confidence in, and clinical application of various predictive models. The primary outcome is the proportion of hepatologists who incorporate prediction models in clinical practice, while secondary outcomes include the level of knowledge about different models, perceived reliability, … |
AALAA MAHMOUD YOUNIS; | 2025-04-01 |
| 23 | Is There A Need for Luteal Support in Modified Natural Cycle Frozen Embryo Transfer Cycles: A Prospective, Multicenter, Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Without progesterone there is no pregnancy. Following ovulation, the endocrine function of the follicle changes and progesterone replacing estradiol becomes its main secretory product. In the follicular phase the increasing amount of estradiol secreted by the growing follicle builds up the endometrium, while in the luteal phase progesterone, the main product of the corpus luteum, prepares the endometrium for implantation. This process is called decidualization. If implantation occurs, … |
PETER KOVACS; | 2025-04-01 |
| 24 | Hepatitis Elimination and Liver Care in South-East Austria (HEAL-S) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The HEAL-S study is a non-interventional study with retrospective data analysis. It consists of two parts. First a retrospective analysis based on nucleic acid testing (NAT) results will be performed. Two cohorts (HCV) and (HBV) will be established. Patients falling into one (or both) of the two cohorts will be invited to a prospective linkage-to-care study. In this part, patients are invited to the clinic, where the possibility of hepatitis treatment will be discussed. |
VANESSA STADLBAUER-KOELLNER; | 2025-04-01 |
| 25 | Characteristic and Survival Outcomes in Hepatocellular Carcinoma Patients: on Top of Viral Hepatitis Versus Combined Viral and Metabolic-Associated Steatotic Liver Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers globally and ranks as the third leading cause of cancer-related deaths . It primarily arises in patients with chronic liver disease and liver cirrhosis, which can result from various etiologies, including viral hepatitis and metabolic disorders. Viral hepatitis, especially Hepatitis B virus (HBV) and Hepatitis C virus (HCV), is well-established as a major risk factor for HCC. Chronic HBV infection is associated with a higher risk of HCC, particularly in areas with high endemicity . Similarly, HCV is linked to significant liver-related morbidity and mortality, … |
ASSIUT UNIVERSITY | 2025-04-01 |
| 26 | Seroprevalence and Vaccination Rate of Hepatitis B Virus and Varicella-zoster Virus Among Medical Students Under Immunizing Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a cross-sectional study. The study aims to determine the levels of immunity against hepatitis B virus and varicella-zoster virus in medical students. |
NARONGKORN SAIPHOKLANG; | 2025-04-01 |
| 27 | A Prospective, Open-Label, Randomized, Controlled, Multicenter Clinical Study of Pegylated Interferon Alfa-2b in Reducing Relapse Rates After Nucleos(t)ide Analogue Withdrawal in HBeAg-Negative Chronic Hepatitis B Patients with Low-Level HBsAg PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: All enrolled patients must meet the European Guidelines for the Prevention and Treatment of Chronic Hepatitis B (EASL, 2017) recommended discontinuation criteria, that is, HBeAg-negative chronic hepatitis B patients without fibrosis or cirrhosis who have undetectable HBV DNA for more than 3 years after receiving NUC treatment can attempt to discontinue the drug. At the same time, the patient’s HBsAg level will not be higher than 1000 IU/mL. The study will set up three groups, group A directly stopped nucleoside analogues, follow-up to 96 weeks; Group B received PegIFNα-2b monotherapy for 48 weeks, … |
JIMING ZHANG; | 2025-04-01 |
| 28 | Effect of Alpha-1 Antitrypsin Supplementation on Alcohol-Associated Hepatitis – A Prospective Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The trial is designed as a prospective, single center, open label, randomized controlled pilot study evaluating the effect of A1AT (Alpha 1 Antitrypsin) on inflammation in patients with severe AAH (alcohol-associated hepatitis). The objective is to evaluate the safety and the effect of intravenous A1AT on the systemic inflammation in patients with severe AAH. The objectives also include the assessment of A1AT on clinical outcomes including the incidence of adverse events (AEs) and serious adverse events (SAEs) and the cytokine. |
MEDICAL UNIVERSITY INNSBRUCK | 2025-04-01 |
| 29 | TRIPL: Thoracic Radiotherapy and Inhibition of PD-1 and LAG-3 for Locally Advanced Non-Small Cell Lung Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Determine anti-tumor efficacy by characterizing response rates on positron emission tomography (PET) following three cycles of induction immunotherapy with cemiplimab and fianlimab without chemotherapy for locally advanced non-small cell lung cancer (LA-NSCLC). |
NITIN OHRI; | 2025-04-01 |
| 30 | Multicenter Retrospective Study on Hepatitis B Virus Protein X (HBx) Screening in Patients with Colitis-associated Cancer (CAC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It was recently discovered that a protein from the Hepatitis B Virus (HBV), called HBx, is highly present in patients who were recently diagnosed with Ulcerative Colitis (UC). This was more common in UC patients than in healthy individuals or those with Crohn’s Disease. About 45% of the UC patients studied had this protein, possibly due to a virus jumping from animals to humans. In experiments with mice, … |
SILVIO DANESE; | 2025-04-01 |
| 31 | Investigating The Metabolic and Lipidomic Profiles That Are Associated With Varying Grades of Diabetic Maculopathy and Retinopathy in South Wales PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus is a disorder of sugar and fat metabolism which results in damage to the small blood vessels in various organs, this includes the retina – the part of the eye that processes light into a nerve impulse. This leads to damage and blindness via various different mechanisms that are not fully understood. In this study the objective is to recruit people with diabetes and various stages of diabetic eye disease and measure a large number of different chemicals within the blood that might be associated with damage and dysfunction within the retina. Additionally, … |
FRANK SANDERS; | 2025-03-31 |
| 32 | A Global, Randomized, Open-label, Multicenter, Phase 2b/3 Trial Evaluating BJT-778 Vs Delayed Treatment for The Treatment of Chronic Hepatitis Delta Infection (AZURE-1) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2b/3 study designed to evaluate the safety and efficacy of chronic treatment with brelovitug (a.k.a BJT-778; BTG) for chronic hepatitis delta virus (HDV) infection. The comparator in this study will be 24-weeks of delayed treatment. During the 24-weeks of delayed treatment, participants will complete the same visits and assessments as those randomized to initiate brelovitug immediately. At the completion of 24-week delayed treatment period, all participants will start treatment with brelovitug. |
BLUEJAY THERAPEUTICS | 2025-03-25 |
| 33 | Description, Course and Treatment of Immune Checkpoint Inhibitor-induced Hepatitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Study Rationale Immune checkpoint inhibitors (ICI) are a breakthrough cancer treatment that boosts the immune system to fight tumors. While effective, they can cause immune-related side effects, including liver inflammation (ICI-induced hepatitis or CHILI), which affects up to 25% of patients. Severe cases requiring treatment discontinuation are rare but challenging to manage. Study Objective This multicenter prospective study aims to better understand CHILI, its clinical patterns, treatment response, and risk of recurrence. It will focus on different types of liver injury (cholestatic, hepatocellular, or mixed) to guide better treatment decisions. Innovation and Approach Currently, … |
UNIVERSITY HOSPITAL MONTPELLIER | 2025-03-25 |
| 34 | Evaluation of Patient Care Support for Cirrhosis And/or Liver Transplants at Pitié Salpêtrière University Hospital PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Cirrhosis is a major challenge in France, with a growing prevalence of 1,500 to 2,500 cases per million inhabitants, and the discovery of 150 to 200 new cases per million inhabitants each year. The main causes are alcohol, hepatitis B and C, and metabolic syndrome. Severe complications of cirrhosis, such as digestive hemorrhage, ascites, hepatic encephalopathy, infections and primary liver cancer, require frequent hospitalization and are more common in advanced stages of the disease. Around 15,000 deaths occur each year, affecting relatively young patients with an average age of 55. At the moment, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-03-19 |
| 35 | A Phase 3 Randomized, Open-Label Study to Evaluate The Efficacy and Safety of Tobevibart + Elebsiran Combination Therapy in Participants With Chronic HDV Infection (ECLIPSE 1) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, open label, randomized Phase 3 clinical study to evaluate the efficacy and safety of the combination of tobevibart + elebsiran for the treatment of chronic hepatitis delta in comparison to delayed treatment. |
VIR BIOTECHNOLOGY | 2025-03-12 |
| 36 | Correlation Between Serum Albumin Level and Severity of Hepatic Encephalopathy in Patients With Chronic Liver Disease in Sohag University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: assess the correlation between serum albumin levels and the severity of hepatic encephalopathy in patients with chronic liver disease. assess the impact of albumin level on clinical course and outcomes of HE. |
KERELOS LATIF SWEHA; | 2025-03-12 |
| 37 | Efficacy and Safety of Ivonescimab (AK112) in Combination with Chemotherapy for The Treatment of Pretreated Pleural Mesothelioma: A Phase II Multicenter, Single-Arm Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective, multicenter, single-arm, Phase II clinical trial evaluating the efficacy and safety of ivonescimab (AK112) combined with chemotherapy in patients with pleural mesothelioma who failed prior immunotherapy, anti-angiogenic therapy, or chemotherapy. The regimen consists of a treatment phase (ivonescimab 20mg/kg combined with pemetrexed 500mg/m²/gemcitabine 1000mg/m²/vinorelbine 25mg/m² every 21 days for 4 cycles) followed by a maintenance phase (ivonescimab monotherapy 20mg/kg every 21 days until disease progression, intolerance, or up to 2 years).The trial plans to enroll 25 patients, with the primary endpoint being objective response rate (ORR). Secondary endpoints include progression-free survival (PFS), overall survival (OS), … |
KEWEI MA; | 2025-03-08 |
| 38 | Efficacy and Implementation Considerations for A Peer-led Motivational Interviewing Intervention to Promote Uptake of Drug Checking Services and Safe Drug Use Behaviors to Reduce Overdose PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A hybrid type 1 study will be conducted to evaluate efficacy and preliminary implementation considerations for a novel intervention to promote uptake of drug checking services (DCS) and safer drug use behaviors among people who use drugs (PWUD) to reduce incidence of overdose (OD) and HIV and Hepatitis C virus (HCV) infections in San Diego County. Along with \~50 other syringe services programs (SSPs) in the US, the Harm Reduction Coalition San Diego (HRCSD), a local SSP, recently launched CheckSD (San Diego), … |
STEFFANIE STRATHDEE; | 2025-03-03 |
| 39 | Seroprevalence of Zoonotic and Arboviral Emerging Infections in Exposed Agents from The City of Montpellier: A Transversal Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments). Most of these diseases are found in certain tropical zones, but global warming and increased international trade are modifying their geographical distribution, with a gradual trend towards temperate regions. A number of these pathogens have already been detected in Occitania, including dengue fever, West Nile, leishmaniasis and Q fever. Given the region’s high mosquito population and favorable climatic conditions, other zoonoses have a strong potential to appear in the region, … |
CHARLOTTE BOULLE; | 2025-03-03 |
| 40 | Efficacy and Safety of Therapeutic Plasma Exchange Vs Standard Medical Therapy in Severe Autoimmune Hepatitis: A Pilot Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that can lead to cirrhosis and liver failure. AIH can present in all ages, races, and ethnicities, but it mostly affects women. As a heterogeneous disease, AIH presents variably in different patients, making diagnosis and treatment a challenge.It is associated with varied clinical presentations and natural history and somewhat unpredictable treatment responses. Steroids and immunosupressants are main stay of treatment.In acute severe presentations corticosteroid response rates are more variable.According to treatment guidelines if patients fail to respond to corticosteroids, … |
INSTITUTE OF LIVER AND BILIARY SCIENCES INDIA | 2025-03-03 |
| 41 | Serum Sialic Acid As A Novel Biomarker in The Diagnosis of Hepatocellular Carcinoma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatocellular carcinoma (HCC) accounts for approximately 90% of the cases of liver cancer and is associated with high morbidity and mortality. The increased sialic acids(SAs) in tumor cells are mainly caused by the special metabolic flux and aberrant expression of sialyltransferases/sialidases, The high sensitivity of sialic acids in or plasma as a tumor marker has been reported in various cancerous conditions the level of sialic acid(SA) activity was found to offer highly specific and sensitive tumor biomarker for diagnosis and follow up of HCC post-therapy. |
EMAN KHALIFA ELSAYED; | 2025-03-01 |
| 42 | Effects of GPS Tracking on Patient Adherence to Hepatitis C Treatment Among People Experiencing Unsheltered Homelessness PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to determine if GPS tracking can enhance adherence to hepatitis C treatment among patients diagnosed with hepatitis C infection who are also experiencing unsheltered homelessness and receiving street medicine. Research will compare medication adherence among participants randomly assigned to receive standard medical care for Hepatitis C versus the standard medical care for Hepatitis C along with GPS tracking assistance. |
CAMILLO ZAKS; | 2025-03-01 |
| 43 | Childhood Obesity Is A Global Health Issue, Especially in Children with Trisomy 21 (T21), Who Face Higher Risks of Non-alcoholic Fatty Liver Disease (NAFLD). Early Detection Using Non-invasive Tools Like Liver Elastography Is Key. Evaluating Dietary Patterns with The 24-hour Food Recall and KIDMED Helps Guide Personalized Interventions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood obesity is a growing public health issue affecting millions of children worldwide, increasing the risk of metabolic and cardiovascular diseases in adulthood. This problem is particularly concerning in children and adolescents with Down syndrome (trisomy 21, T21), who have a higher predisposition to fat accumulation due to genetic, metabolic, and behavioral factors. However, assessing their nutritional status and body composition is challenging, … |
LORENA LOPEZ LORA; | 2025-03-01 |
| 44 | Safety and Efficacy of Akkermansia Probiotics Combined with Anti-PD-1 Monoclonal Antibody in MSS/pMMR Advanced Colorectal Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators propose to conduct a single-center, single-arm, Phase I clinical study to explore the safety and efficacy of Akkermansia probiotics combined with anti-PD-1 monoclonal antibody in patients with MSS/pMMR advanced colorectal cancer, as well as its impact on gut microbiota and the immune microenvironment. |
MENG QIU; | 2025-02-21 |
| 45 | Universal Screening for Hepatitis Delta Virus (HDV) in Individuals Living with HIV/HBV Coinfection and HBV-related HCC PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a territory-wide cross-sectional study of all individuals living with HIV/HBV coinfection and HBV-related HCC. |
GRACE LAI HUNG WONG; | 2025-02-15 |
| 46 | Mesenchymal Stem Cells Infusion in Patients With Autoimmune Diseases – A Phase II Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn if mesenchymal stem cell therapy (treatment group) can effectively treat autoimmune diseases, when compared to normal saline (given to placebo group). The primary outcome measures will be clinical improvement based on the respective disease specific clinical scores, normalization of T-lymphocyte subsets and \> 50% reduction in disease specific antibody titres. The study will also document the type and frequency of any adverse event or side effects, … |
NATIONAL INSTITUTE OF BLOOD AND MARROW TRANSPLANT NIBMT PAKISTAN | 2025-02-01 |
| 47 | Holmium-166 Transarterial Radioembolization for The Treatment of Hepatocellular Carcinoma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effectiveness and safety of Holmium-166 (Ho-166) transarterial radioembolization (TARE) for treating patients with locally advanced hepatocellular carcinoma (HCC), a common type of liver cancer. HCC is often linked to conditions like liver cirrhosis and viral hepatitis, with a poor prognosis for advanced stages. TARE involves delivering radioactive particles directly to liver tumors, sparing healthy tissue and providing targeted radiation. This study will include patients diagnosed with HCC who have received Holmium-166 TARE treatment between January 2010 and December 2024. Researchers will look at patient and tumor characteristics, side effects, how well the treatment works, … |
UNIVERSITAIR ZIEKENHUIS BRUSSEL | 2025-02-01 |
| 48 | Branch Chain Amino Acids Vs. Rifaximin in Patients with Cirrhosis for Secondary Prophylaxis of Hepatic Encephalopathy: Double-blind Placebo-controlled Multicentric Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale * Patients who recover from an episode of overt HE(OHE) are at risk of recurrent episodes of HE and persistent minimal hepatic encephalopathy, impacting their daily functioning and mental health. * A multicentric pan-India team will evaluate the role of oral branched-chain amino acids (BCAA) vs Rifaximin as secondary prophylaxis following overt HE as compared with improvement in cognitive function. Novelty: * This study is intended to investigate the role of BCAA vs rifaximin as the ideal second-line therapy for HE management, recurrence, and overall health, including cognitive function, … |
MADHUMITA PREMKUMAR; | 2025-02-01 |
| 49 | A Pilot Study of The Combination of VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Chronic hepatitis B virus (HBV) infection affects 292 million people worldwide; 887,000 die each year from cirrhosis, liver cancer, and related issues. Treatment options are limited. Objective: To test 2 drugs (VIR-2218 and peginterferon) in people with mild or inactive HBV infection. Eligibility: People aged 18 to 65 years with mild or inactive HBV infection. Design: Participants will be screened. They will have blood tests and an eye exam. They will have imaging scans of the liver to check the health of the liver. Participants will be in the study for over 2 years. VIR-2218 is an injection given under the skin of the stomach, upper arm, or thigh. Participants will come to the clinic to receive this injection once a month for 6 months. Peginterferon is also injected under the skin. Participants will have this shot once a week for 6 months. They may either inject themselves at home or come to the clinic to get the injections. Participants will get just the VIR-2218 for 3 months, then both shots for 3 months, then just the peginterferon for 3 months. Participants will have two 3-day stays in the hospital. Tests will include: Liver biopsy. A sample of tissue will be taken from their liver. After the procedure, participants will lie on their right side for 2 hours and then on their back for 4 hours. Fine needle aspiration. A small needle will be used to collect cells from the liver. After the last injection of peginterferon, follow-up visits will continue in the outpatient clinic every 4 to 12 weeks. |
MARC G GHANY; | 2025-01-31 |
| 50 | A Phase 1a, Blinded, Placebo-Controlled Study of The Safety, Tolerability and Pharmacokinetics of Single- and Multiple-Ascending Doses of ABI-6250 in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to assess safety, tolerability, and pharmacokinetics of single ascending doses (SAD) and multiple-ascending doses (MAD) of ABI-6250 in healthy participants. Effect of food will also be evaluated in Part A. |
ASSEMBLY BIOSCIENCES | 2025-01-31 |
| 51 | Dried Blood Spot Testing in Peer-assisted Telemedicine for Hepatitis C Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the rate of treatment initiation achieved by peer-assisted telemedicine contingent on phlebotomy (usual care) versus that achieved with a new protocol, called Dried Blood Spot Test and Treat (DBS TaT). DBS TaT includes DBS testing to diagnose hepatitis C (HCV), utilizes a novel clinical decision aid that identifies patients who are low risk for hepatic (liver) fibrosis, … |
HUNTER SPENCER; | 2025-01-22 |
| 52 | Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute liver failure (ALF) is a serious condition in which the liver suddenly stops working, often leading to life-threatening complications. While N-Acetylcysteine (NAC) is widely used to treat ALF caused by acetaminophen overdose, its benefits in ALF due to other causes, such as viral infections or drug reactions, remain uncertain. This study is a randomized controlled trial designed to investigate whether NAC can improve survival rates and reduce hospital stays in patients with non-acetaminophen-induced ALF. Participants will be randomly assigned to receive either NAC along with standard supportive care or standard supportive care alone. The study will measure survival rates, … |
MUHAMMAD IRFAN JAMIL; | 2025-01-15 |
| 53 | Expanded Access Treatment Protocol for Bulevirtide Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to provide access to bulevirtide (BLV (GS-4438), Hepcludex®) to eligible participants with chronic hepatitis delta virus infection (CHD). |
GILEAD SCIENCES | 2025-01-13 |
| 54 | Intestinal Microbiota Transplant As A Strategy to Enhance The Resilience Capacity of The Elderly Aiming to Retain Muscular, Cognitive, and Metabolic Functions in A Stressful Environment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sarcopenia, characterized by the progressive loss of muscle mass and strength in older adults, is a key factor in health deterioration. It affects 15% of people between 65 and 80 years old and over 50% of those over 80, compromising autonomy and increasing the risk of diseases. Sarcopenia not only impacts muscle function but also bone health, mobility, and is associated with cardiometabolic diseases and cognitive decline. It has been proposed that changes in the gut microbiota in aging individuals, known as gut dysbiosis, contribute to sarcopenia. Species diversity decreases, and bacterial representation is altered, … |
GONZALO JORQUERA; | 2025-01-10 |
| 55 | Safety and Efficacy of Hepatitis B Virus (HBV)-Specific T Cell Receptor (TCR)-T Cell Therapy Combined with Nucleos(t)ide Analogues (NAs) in HBeAg-Positive Chronic Hepatitis B Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a open-label study to evaluate the safety and efficacy of autologous T-cells transfected with messenger ribonucleic acid (mRNA) encoding Hepatitis-B virus (HBV) antigen specific T cell receptor (TCR) in combination with nucleos(t)ide analogues (NAs) in HBeAg-positive chronic hepatitis B patients. |
CHANGHAI HOSPITAL | 2025-01-01 |
| 56 | Effect of Cırcadıan Feedıng on Growth Parameters of Preterm Newborn PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was planned as a randomized controlled experimental study to determine the effect of circadian feeding on the growth parameters of preterm newborns. The data of the study were collected from patients aged 32-34 in the Neonatal Intensive Care Unit (NICU) of Selçuk University Faculty of Medicine. It will consist of premature babies and mothers born during the first week of gestation. The sample size was planned to include 48 preterm newborns and their mothers. Mother-Preterm Introductory Information Form, Breast Milk Feeding Follow-up Form, Breast Milk Content Parameters Follow-up Form, Newborn Baby Follow-up Form, … |
AYSE SONAY TURKMEN; | 2025-01-01 |
| 57 | Assessment of Interleukin 8 and 10 Level Changes Before and During Root Canal Treatment for Necrotic Pulp with Apical Periodontitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate changes in interleukin 8 (IL-8) and interleukin 10 (IL-10) levels in gingival crevicular fluid (GCF) and periapical fluid during root canal treatment in patients with necrotic pulp and apical periodontitis. The main question it aims to answer is: How do IL-8 and IL-10 levels in GCF and periapical fluid change over the course of treatment? Participants will: Provide samples of GCF and periapical fluid at two different time points during their root canal treatment. Undergo treatment based on standard clinical protocols for necrotic pulp and apical periodontitis. |
ESRAA MOHAMED ELSAGHEER HASSAN; | 2024-12-15 |
| 58 | Belimumab in The Management of Autoimmune Hepatitis: A Multi-centre, Open-label Trial of Add-on Belimumab Therapy to Standard of Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Autoimmune hepatitis (AIH) is a rare chronic and lifelong liver disease. Untreated, disease progresses to end-stage cirrhosis and the focus of therapy is with immunosuppression. Current therapies are limited, not targeted, and associated with side effects that patients report reduce quality of life. AIH is believed to arise as a consequence of genetic \& environmental risks. Disease is characterised by impaired immunoregulation, that favours a chronic and relapsing hepatitis. As well as recognising an important role for cytotoxic T cells and regulatory T cells, it has become apparent that in AIH, as well as other related autoimmune conditions, … |
GIDEON HIRSCHFIELD; | 2024-12-11 |
| 59 | A Parallel-group, Randomized, Open-label Clinical Trial of Hepalatide for Injection in Patients With Chronic Hepatitis D PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the efficacy and safety of L47 in the treatment of chronic hepatitis D. Patients with compensated CHD who satisfy the eligibility criteria are stratified by the presence or absence of liver cirrhosis and randomized into three groups at a 1:1:1 ratio. The subjects will receive continuous L47 (2.1 mg/d and 4.2 mg/d, s.c.) treatment for 48 weeks (groups A and B), or delayed treatment for 48 weeks (group C). Primary endpoint evaluation will be performed after the subjects complete the 48-week treatment. |
OYUNBILEG JANCHIV; | 2024-12-11 |
| 60 | A Multicenter, Prospective, Cohort Study Evaluating The Efficacy of Trop-2 ADC Combination Therapy in Advanced Triple-Negative Breast Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Research purposes: the research design in the late more than 2 lines TNBC prospective, multicenter, cohort study, respectively to observe Trop2 – ADC joint PD – 1 single or combined anti-angiogenesis drugs (macromolecular single bevacizumab or small molecules TKI resistance, for, as the default layered) the efficacy and safety. Indications: Trop2 – ADC joint PD – 1 single or combined anti-angiogenesis drugs (macromolecular single bevacizumab or small molecules TKI resistance, for, as the default layered) treat above 2 late three negative breast cancer (TNBC). |
CHUNFANG HAO; | 2024-12-06 |
| 61 | Evaluate TQ-A3334 Tablets Combined Nucleoside (Acid) Analogs in The Initial Treatment/Chronic Hepatitis B Virus (HBV) Infection Subjects of Chronic HBV Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study uses random, double -blindness, placebo control, and phase multi -center test design. All subjects who meet the standards receive TQ-A3334 per tablet/placebo nucleoside (acid) analog. A total of 116 subjects are needed. |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2024-12-04 |
| 62 | The Benefits of Improving Self-care Ability for Farmers and Fishermen With Existing Cardiometabolic Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will be based on nursing scholar Dorothea Orem’s self-care theory, integrating the concept of the \[life essential 8, LE8\] proposed by the American Heart Association, as well as our team’s recent research findings. We aim to develop educational materials and tools tailored for this group, termed \[Self-Care Eight Essentials\] aligning with these theories and previous research outcomes. This study aims to present an overview of self-care abilities among farmers and fishermen with cardiovascular and metabolic diseases, … |
MEI-YEN CHEN; | 2024-12-02 |
| 63 | Admission to The Kangaroo Mother Care Ward and Maternal Postpartum Depression: A Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if extended admission to the Kangaroo Mother Care (KMC) ward helps to prevent postpartum depression in mothers of low birthweight infants in a low-resource setting whose newborns were admitted to the neonatal intensive care unit (NICU) more than standard of care KMC. The main questions it aims to answer are: * Does longer KMC decrease the incidence of postpartum depression in mothers of low birthweight infants in a low-resource setting? * Does longer KMC improve neurodevelopmental outcomes of low birthweight infants at 6, 12, … |
ALBERT MANASYAN; | 2024-12-01 |
| 64 | The Impact of Hepatitis B Virus Infection on The Clinical Course of Inflammatory Bowel Disease in Egyptian Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational retrospective study is to assess the impact of hepatitis B virus (HBV) infection on the clinical course and outcomes of inflammatory bowel disease (IBD) in Egyptian patients. Researchers will compare the IBD extent, location, severity, and behavior between IBD patients with and without HBV infection. Participants will be subjected to history-taking (history of hospital admission and disease flare, surgical history, medication history, follow-up duration, and mortality), clinical examination, laboratory investigations, abdominal ultrasonography, and endoscopic examination. |
RANIA MAMDOUH ELKAFOURY; | 2024-12-01 |
| 65 | Recompensation in Alcohol Related Hepatitis- A Prospective Cohort with Alcohol Cessation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Genetic activity and metabolic changes may be part of the pathogenesis in alcohol related hepatitis. We do not know exactly how alcohol cessation affects liver functions and metabolism. The aim of this study is to assess the impact of alcohol cessation in patients with alcohol related hepatitis and gain knowledge of the metabolic and genetic functions of the liver during remission and recompensation from alcohol related hepatitis. The study will assess 1. The effect of alcohol cessation on the liver. 2. The biological mechanisms involved in healing after alvohol-cessation 3. The effect of motivational enhcament therapy in alcohol cessation after alcohol related hepatitis. 4. The metabolic changes of lipids and proteins in the liver Participants are offered motivational enhancement therapy and standard of care. |
NINA KIMER; | 2024-11-25 |
| 66 | A Phase 1, Open-Label, First-in-Human, Dose Escalation (Part 1) and Expansion (Part 2) Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of PBGENE-HBV in Participants with Chronic Hepatitis B (ELIMINATE-B) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1, open-label, dose escalation and dose expansion study to evaluate the safety, tolerability, PK, and antiviral activity of PBGENE-HBV in adult participants with chronic hepatitis B. |
PRECISION BIOSCIENCES | 2024-11-14 |
| 67 | A Phase 2 Clinical Trial Investigating The Safety and Efficacy of ADX-629 in Subjects with Alcoholic Hepatitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase 2 Clinical Trial Investigating the Safety and Efficacy of ADX-629 in Subjects with Alcoholic Hepatitis (Part 1) |
ALDEYRA THERAPEUTICS | 2024-11-04 |
| 68 | Hepatitis Delta Virus Infection: Cross-sectional Study in Patients With Chronic Hepatitis B Virus Infection PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to determine the prevalence of hepatitis D virus (HDV) and the distribution of the HDV genotype in patients with chronic hepatitis B infection. It will also identify factors related to hepatitis D virus infection, such as characteristics of the study sample, vaccination history, drug use affecting hepatitis, family factors, environment, and lifestyle. This study will be conducted at Tam Anh General Hospital, … |
TAM ANH RESEARCH INSTITUTE | 2024-11-01 |
| 69 | Nomogram for Predicting Postoperative Early Biliary Complication in Adult Patients Following Liver Transplantation: A Retrospective Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to develop a nomogram model to predict biliary complications within 90 days in adult patients after liver transplantation. The main questions it aims to answer are: Can the nomogram predict biliary complications within 90 days in adult patients after liver transplantation? What about the performance of the nomogram? Researchers will compare patients’ preoperative variables, intraoperative factors, and postoperative outcomes to see what factors are associated with biliary complications.Subsequently, multivariable logistic regression analysis was conducted to evaluate the factors associated with biliary complications occurring within 90 days post-liver transplantation. Finally, a nomogram was developed. |
ZEPENG LIN; | 2024-11-01 |
| 70 | Comparison Between Conventional Ultrasound and Remote Ultraportable UlTrasound for Abdominal Examination in The Context of Viral Hepatitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparison of abdominal US exam in patients with viral hepatitis between ultraportable US with teleradiology capacities (TUP) versus conventional ultrasound (CUS) |
NAIK VIETTI VIOLI; | 2024-11-01 |
| 71 | A Phase 2 Multicenter, Randomized, Double-Blind Study to Evaluate The Efficacy and Safety of Combination Therapy of BRII-179, BRII-835 and Pegylated Interferon Alpha (PEG-IFNα) in Participants With Chronic Hepatitis B Virus (HBV) Infection (ENHANCE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase 2, randomized, double-blind study will evaluate the clinical efficacy and safety of the combination therapy of BRII-179, BRII-835, plus PEG-IFNα compared to PEG-IFNα in adult participants with chronic HBV infection without cirrhosis receiving neucloes(t)ide reverse transcriptase inhibitors (NRTIs) as background therapy. |
BRII BIOSCIENCES | 2024-10-31 |
| 72 | Clinical Study Evaluating The Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this clinical trial is to Evaluate the Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate. Methodology: This is a randomized, double blind placebo controlled parallel study that will be conducted on 44 patients with active rheumatoid arthritis. Group1 (placebo group; n=22) which will receive IM or SC Methotrexate plus placebo tablet once daily for 3 months. Group2 (Empa group; … |
NEHAD WALEED KARAM; | 2024-10-15 |
| 73 | Study on The Effectiveness and Safety of Topical Human Granulocyte Macrophage Stimulating Factor Gel in The Treatment of Diabetic Wounds During The Granulation Growth Phase PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: With the aging of the population, the incidence of diseases such as diabetes, chronic atherosclerotic occlusion, cerebrovascular disease, and cancer is increasing year by year, and has led to an increasing incidence of chronic wounds such as diabetic foot, ischaemic ulcers, venous ulcers, pressure injuries, and radiation ulcers. In addition to the high age and chronic diseases that make the treatment of wounds difficult and long, chronic wounds remain in the proliferative stage, unable to carry out normal repair, which is also an important reason for the prolonged healing of wounds, … |
LONG ZHANG; | 2024-10-12 |
| 74 | Effect of Propofol and Sevoflurane Anesthesia on HSP70 Expression in Tumor Cells. A Prospective, Single-center, Pilot, Randomized Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if sevoflurane-based inhalational anesthesia (s-IA) and propofol-based total intravenous anesthesia (p-TVA) have different effects on HSP70 expression in different types of tumour cells. The main questions it aims to answer are: – if p-TVA/s-IA increase or suppress HSP70 expression in tumor cells in comparison with a pre-anesthesia level; – does this change in HSP70 expression cause any difference in vital characteristics of tumor cells, such as proliferation, apoptosis, … |
EFREMOV SERGEY; | 2024-10-10 |
| 75 | Lay User Evaluation of The Panbio™ HCV Self Test: A Prospective, Multi-centre Observed Untrained User Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, multi-centre study designed to evaluate the usability of the Panbio™ HCV Self Test, when performed by untrained lay users in an observed study setting. The Panbio™ HCV Self Test detects antibodies to Hepatitis C Virus (HCV). The study validation will be conducted in accordance with the World Health Organisation’s technical guidance on Hepatitis C rapid diagnostic tests for professional use and/or self-testing (TSS-16). |
HUMA QURESHI; | 2024-10-01 |
| 76 | Accupower ® HBV Performance Evaluation Quant Kit Bioneer Existation™FA 96/384 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As part of the CE marking of a hepatitis B diagnostic kit, the South Korean manufacturer Bioneer wishes to set up a performance study in France in accordance with the IVDR (RE 2017/746). Cerba Xpert CRO of the Cerba Healthcare group promoted this performance study by setting up a prospective collection of blood samples from patients with hepatitis B virus and whose viral load is positive. This prospective collection will be carried out in 3 laboratories of the Cerba Healthcare group. |
CERBAXPERT | 2024-10-01 |
| 77 | A Phase 1, First-in-human, Open-label Study to Evaluate The Safety, Tolerability, PK, and Preliminary Anti-tumor Activity of The Novel Oral CDK2 Degrader NKT3964 in Adults With Advanced/Metastatic Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the Dose Escalation phase of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity to determine the preliminary recommended dose for expansion (RDE) of NKT3964 in adults with advanced or metastatic solid tumors. The goal of the Expansion phase of the study is to evaluate the preliminary anti-tumor activity of NKT3964 at the RDEs based on objective response rate (ORR) and determine the preliminary recommended Phase 2 dose (RP2D). |
NIKANG THERAPEUTICS | 2024-09-19 |
| 78 | A Multicenter, Randomized, Double-Blind, Placebo-controlled Study to Assess The Efficacy and Safety of Treatment With Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection on Antiretroviral Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the efficacy and safety of bepirovirsen compared to placebo in participants with human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infection. |
MAURIZIO BONACINI; | 2024-09-17 |
| 79 | Phase 2 Dose-Ranging and Interception Study of Linvoseltamab in Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of the study is to understand how well the study drug can eliminate abnormal plasma cells and laboratory signs of high-risk monoclonal gammopathy of undetermined significance (HR-MGUS) and non high-risk smoldering multiple myeloma (NHR-SMM). This requires understanding the safety and tolerability of the study drug (how the body reacts to linvoseltamab) as well as the effectiveness of the study drug (how well linvoseltamab eliminates plasma cells). All participants will start treatment with gradually increasing doses of linvoseltamab (step-up doses) before they start receiving the assigned full dose. The study is split into 2 parts: * In Part 1, separate groups of 3-6 patients will receive different full doses of linvoseltamab to evaluate the short-term side effects (safety) and tolerability of the study drug within the first 5 weeks after starting treatment. The data collected will help to make a decision about the dosing regimens chosen for Part 2. * In Part 2, a larger number of participants will be randomized to different dosing regimens to further assess the side effects of linvoseltamab, and to evaluate the ability of linvoseltamab to eliminate abnormal plasma cells in HR-MGUS and NHR-SMM. The study is looking at several other research questions, including: * How many participants treated with linvoseltamab have improvement of their HR-MGUS or NHR-SMM? * What side effects may happen from taking the study drug? * How much study drug is in the blood at different times? * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects). |
REGENERON PHARMACEUTICALS | 2024-09-16 |
| 80 | Phase I/II Trial of Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Chronic Lymphocytic Leukemia (CLL) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are blood cancers that affect certain white blood cells. Advanced forms of these diseases are difficult to treat. CD19 is a protein often found on the surfaces of these cancer cells. Researchers can modify a person’s own immune cells (T cells) to target CD19. When these modified T cells are returned to the body-a treatment called anti-CD19 chimeric antigen receptor (CAR) T cell therapy-they may help kill cancer cells. Objective: To test anti-CD19 CAR T cell therapy in people with CLL or SLL. Eligibility: People aged 18 years and older with CLL or SLL that has not been controlled with standard drugs. Design: Participants will be screened. They will have imaging scans and tests of their heart function. If a sample of tissue from their tumor is not available, a new one may be taken; the sample will be tested for CD19. Participants will receive a drug to reduce the leukemia cells in their blood. Then they will undergo apheresis: Blood will be taken from the body through a needle. The blood will pass through a machine that separates out the T cells. The remaining blood will be returned to the body through a different needle. The collected T cells will be gene edited to make them attack cells with CD19. Participants will take drugs to prepare them for treatment for 3 days. These drugs will start 5 days before the treatment. Then their own modified CAR T cells will be returned to their bloodstream. Participants will stay in the hospital for at least 9 days after the treatment. Follow-up visits will continue for 5 years. |
JENNIFER N BRUDNO; | 2024-09-03 |
| 81 | Clinicopathological, Endoscopic and Serological Patterns of Celiac Disease in Children at Sohag University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim is to study the clinical, serological, endoscopic and histopathological characteristics and treatment outcome of children diagnosed with celiac disease in Sohag University Hospital |
AHMED ALI ABDELRAHEEM; | 2024-08-25 |
| 82 | Lay User Evaluation of The Panbio™ HCV Self Test in An EU Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is part of the performance evaluation to support the conformity assessment procedure for the use of fingerstick whole blood samples with Abbott’s Panbio™ HCV Self Test device, as performed by lay users. The study will be conducted in accordance with the Commission Implementing Regulation (EU) 2022/1107 of 4 July 2022 laying down common specifications for certain class D in vitro diagnostic medical devices in accordance with Regulation (EU) 2017/746 of the European Parliament and of the Council and, to provide data to demonstrate the product is safe and effective for its intended use. |
PABLO RYAN; | 2024-08-01 |
| 83 | Phase I Clinical Study to Evaluate The Safety and Tolerability of A Monovalent Influenza A (H7N9) Vaccine Delivered Intradermally By High-density Microarray Patch (HD-MAP) in Healthy Adults Aged 18 to 50 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study SP-1219-007 is a multi-centre, randomised, study designed to access the safety and tolerability of two doses of monovalent Influenza A (H7N9) vaccine delivered intradermally by a microarray patch delivery system in healthy adults aged 18 to 50 years. |
VAXXAS PTY | 2024-07-31 |
| 84 | Intra-Hepatic Microbiota in Alcoholic Hepatitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Alcoholic hepatitis (AH) is a serious complication of alcoholic liver disease (ALD). The histological presentation of AH is characterized by neutrophilic lobular inflammation, macrovesicular steatosis, hepatocyte ballooning and necrosis and the presence of Mallory bodies. In cases of severe HA, defined by a modified Maddrey score of 32 or above, mortality at 1 month is estimated at between 10 and 50%. The only treatment to reduce early mortality is corticosteroid therapy. However, only 60% of patients respond to corticosteroids, … |
HOSPICES CIVILS DE LYON | 2024-07-23 |
| 85 | Effectiveness and Safety of Atezolizumab and Bevacizumab Plus Transarterial Chemoembolization As Conversion Therapy Among Patients With Initially Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice in China PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, retrospective, observational cohort study to describe the effectiveness and safety of Atezo+Bev plus Transarterial Chemoembolization (TACE) among adult patients with unresectable hepatocellular carcinoma (HCC) in real-world clinical practice in China. Eligible patients diagnosed with unresectable HCC initiating the Atezo+Bev and TACE between 28 October 2020 and 31 December 2023 will be included in this study. |
HOFFMANN LA ROCHE | 2024-07-19 |
| 86 | A Phase 1, Randomized, Double-Blinded, Placebo-Controlled, Parallel Group Study to Evaluate The Effect of Bepirovirsen on Cardiac Conduction As Assessed By 12-lead Electrocardiogram in Healthy Volunteers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effect of a single dose of bepirovirsen on the QT interval corrected by Fridericia’s formula (QTcF) as compared to placebo. The data generated will be used to model the relationship between bepirovirsen concentration and QTcF. |
BRIAN SPEARS; | 2024-07-18 |
| 87 | Specific Biomarkers of Immune-mediated Hepatitis Secondary to Immune Checkpoint PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Identify specific blood biomarkers for hepatitis induced by immune checkpoint inhibitors in comparison to idiopathic autoimmune hepatitis. |
LUCY MEUNIER; | 2024-07-17 |
| 88 | The Effect of Mechanical Vibration and Helfer Skin Tap Technique on Procedural Pain in Healthy Infants During Intramuscular Vaccination: A Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to determine the effect of mechanical vibration and Helfer Skin Tap technique applied during intramuscular Hepatitis B vaccination on procedural pain level, crying time and procedure time in healthy infants. |
AYNUR AYTEKIN OZDEMIR; | 2024-07-15 |
| 89 | Open-labeled, Randomized, Controlled Phase IV Clinical Trial to Evaluate The Immunogenicity and Safety of Booster Dose of SIPV Co-administered With MMR and HepA-I PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an Open-labeled, Randomized, Controlled Phase IV Clinical Trial to Evaluate the Immunogenicity and Safety of Booster Dose of Sabin Strain Inactivated Poliovirus Vaccine (Vero cell) (sIPV) Co-administered with Measles, Mumps, Rubella (MMR) Combined Live Attenuated Vaccine and Inactivated Hepatitis A (Hep-A) Vaccine. |
PAN HONGXING; | 2024-07-10 |
| 90 | Analysis of Liver Injury Risk Factors in A Multiethnic Population Treated With Antituberculosis Drugs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is the world’s second leading cause of death from a single infectious agent after COVID-19. In 2022, TB was estimated to have affected 10.6 million people, of whom 1.3 million died because of it, despite the WHO’s implementation of the End TB program. Although the gold standard therapy is effective, it may lead to adverse events, among which hepatotoxicity is the most common. Due to its frequency, severity, and potential outcome, anti-TB drug-induced liver injury (DILI) is extremely concerning. Despite decades of use and the large number of patients exposed to anti-TB drugs worldwide, … |
STEFANIA CHELI; | 2024-07-05 |
| 91 | Randomized, Multi-center Phase II Study to Evaluate The Efficacy and Safety of AHB-137 in HBeAg-negative CHB Subjects Under Stable Nucleos(t)Ide Analogue (NA) Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: AB-10-8003 is a randomized, multi-center phase II study to evaluate the efficacy and safety of AHB-137 in subjects with HBeAg-negative CHB under stable NA treatment. |
JUNQI NIU; | 2024-07-05 |
| 92 | IMplementation of CAB+RPV LA for People With HIV in Non-Metropolitan Areas: Addressing Adherence Barriers Through Learning and Evidence-Informed Strategies (IM-CAPABLE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this implementation science study is to learn about the experience of receiving and providing cabotegravir + rilpivirine long-acting (CAB+RPV LA) injections as treatment for human immunodeficiency virus (HIV) for people who live a significant distance from an HIV provider. The main questions it aims to answer are: * Is CAB+RPV LA feasible and acceptable to patients and staff? * What barriers and supports exist and have the most impact on receiving and providing CAB+RPV LA? * How does CAB+RPV LA affect HIV stigma, treatment satisfaction, … |
NADA FADUL; | 2024-07-01 |
| 93 | A Phase I, Double-blind, Randomized, Placebo-controlled, Dose Escalating Study to Evaluate The Safety, Immunogenicity and Efficacy of YS-HBV-002 in The Treatment of Chronic Hepatitis B (CHB) Infection in Adults ≥ 18 Years Old PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is the first-in-human Phase I, double-blind, randomized, placebo-controlled, dose escalating study to evaluate the safety, immunogenicity and preliminary efficacy of the YSHBV-002 in the treatment of CHB in adults ≥18 years old. There will be 3 escalating doses of YS-HBV-002 to be administered intramuscularly: 0.5mL, 1.0mL, and 2.0mL. |
IKE MINERVA; | 2024-07-01 |
| 94 | Feasibility Pilot Study to Evaluate The Safety and Performance of The MEX-CD1 Medical Device in Acute on Chronic Liver Failure (ACLF) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test the MEX-CD1 hemodialysis medical device in patients suffering from ACLF. The main questions it aims to answer are: * Is the device safe when used according to the instructions for use? * Does the device work as expected by removing the excess of free iron from the blood? Patients will receive 3 MEX-CD1 Slow Low volume CVVHD within 1 week. |
CÉLINE GUICHON; | 2024-06-21 |
| 95 | Screening for Hepatitis C in People Who Inject Drugs in Armenia-Colombia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C virus infection is a major cause of chronic hepatitis, cirrhosis, and liver cancer. The risk of developing cirrhosis for people with chronic infection with the virus ranges from 15% to 30% over 20 years. Despite undeniable advances in the treatment of hepatitis C infection and the WHO strategy to eliminate hepatitis C by 2030, this infection continues to be a major public health problem globally and many HCV-positive individuals are unaware of their HIV status. People who inject drugs (PWID) are at increased risk for HCV. Several studies have reported high HCV prevalence rates, … |
DIANA ROCIO CHAVEZ BEJARANO; | 2024-05-20 |
| 96 | Study Of Patients With Obstructive Jaundice In Sohag University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study of patients with obstructive jaundice in Sohag university hospital study the clinical, laboratory and imaging charachteristics in patients with obstructive jaundice admitted to sohag university hospital, and to study the available therapeutic options which meight improve patient’s quality of life and increase survival rates. |
AL SHAIMAA IBRAHIM HAMDY; | 2024-05-20 |
| 97 | Increasing The Feasibility, Impact, and Equity of The Medicare Annual Wellness Visit (AWV) PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to improve the use of preventive health services by implementing a multilevel intervention to stimulate Annual Wellness Visit use in diverse practices across the United States. This is a stepped wedge cluster randomized controlled trial. The intervention will be implemented in a total of 24 primary care practices over 24 months. Every 3 months, … |
DERJUNG TARN; | 2024-05-01 |
| 98 | Implementation of A Re-engagement Program for Hepatitis C Patients Lost to Follow-up in Argentina PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C virus (HCV) is a leading cause of morbidity and mortality worldwide. This infection continues to represent a major global public health concern. This is why the introduction of potent antivirals for the treatment of HCV has been one of the major breakthroughs of the current medical era. From a public health perspective, HCV prevalence will be eliminated if the available treatment also targets those most likely to transmit the virus. Despite this scientific advance, a systematic review from the U.S. described that of the 43% of patients aware of their HCV diagnosis, only 16% started treatment. Clearly, … |
FERNANDO MARIO CAIRO; | 2024-05-01 |
| 99 | Effectiveness of Brahma Kumaris Raja Yoga Meditation on Quality of Life of Youth Residing in The Deaddiction Center of Biratnagar PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Drug addiction is a public health problem, mainly youths are involved in the addiction and the major reason were due to peer pressure. Spiritual meditation is thought to foster a deeper sense of meaning, which creates new sources of positive reinforcement, increasing motivation for alternative behavior patterns, such as entering treatment or maintaining abstinence. Cluster Randomized Control Trial will be performed for 1-year period where mixed method study design will be performed. The major variables will be Anxiety and depression score, Happiness index, Quality of life, Rate of Relapse, Age, Gender, Occupation, Education, Income, Family Size, Family Income, Family support, … |
RAJIV RANJAN KARN; | 2024-05-01 |
| 100 | The Effect of Facilitated-tucking, ShotBlocker, and The Combination of The Facilitated-tucking and ShotBlocker on Pain Caused By Hepatitis-B Vaccination in Healthy Term Infants: Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be investigated the effects of facilitated tucking, ShotBlocker and combined facilitated tucking and ShotBlocker methods on procedural pain, crying time and duration of the procedure during Hepatitis B vaccine administration in healthy term infants. |
AYNUR AYTEKIN OZDEMIR; | 2024-05-01 |
| 101 | The Link Between Human Cytomegalovirus Gene Expression and Glutamate Levels in Migraine :Relationship to The Vit D Deficiency PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To correlate serum 25(OH)-vitamin D level with duration, frequency, and severity of migraine headache attacks 2. To evaluate the relationship between the serum level of vitamin D and other indices in patients with migraine. 3. To correlate the serum level of glutamate with gene expression of in migraine |
AHMED MOHAMED OMAR ALI; | 2024-05-01 |
| 102 | Hepatitis C Lab Testing Comparison Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C (HCV) HCV antibody assays are the standard of care test used to screen for HCV, but confirmation of acute infection is relegated in the current US guidelines to polymerase chain reaction (PCR) which often takes multiple days and may result in a loss to follow up and treatment, especially in high prevalence populations. HCV core antigen is a new, research use only immunoassay intended for use on the Abbott Alinity i system, … |
IAN GUNSOLUS; | 2024-05-01 |
| 103 | Ending HIV and Taming Hepatitis C Virus and Overdose Among Puerto Rican People Who Inject Drugs in New York City: The Ganchero Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot clinical trial is to learn if an intervention that trains Gancheros (people who provide injection services in exchange for drugs or money) to conduct risk-reduction outreach could help lower risk for human immunodeficiency virus (HIV), … |
NORTH JERSEY AIDS ALLIANCE DBA NORTH JERSEY COMMUNITY RESEARCH INITIATIVE NJCRI | 2024-05-01 |
| 104 | A Randomized, Blinded, Placebo-Controlled Dose-Ranging Phase 1b Study of The Safety, Pharmacokinetics, and Antiviral Activity of ABI-4334 in Subjects With Chronic Hepatitis B Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, blinded, placebo-controlled, dose-ranging Phase 1b study of the safety, PK, and antiviral activity of ABI-4334 in treatment-naïve or off-treatment chronic Hepatitis B virus (cHBV) subjects that are Hepatitis B e antigen (HBeAg) positive or negative. The study will enroll up to 5 sequential cohorts of 10 subjects each, for a total of up to 50 subjects, randomized 8:2 to receive ABI-4334 or placebo. |
ASSEMBLY BIOSCIENCES | 2024-04-30 |
| 105 | Efficacy of Plasma Exchange Therapy Vs Standard Medical Therapy in Severe Alcoholic Hepatitis With High Discriminant Function : A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Alcoholic hepatitis, the most florid form of alcoholic liver disease, has a very high short-term mortality of up to 50% and no specific therapies are available other than steroids. Steroids also only show a limited utility in improving the short-term survival and boast no evidence of any long-term benefits. Additionally, only a small proportion of patients with alcoholic hepatitis are eligible to receive steroids. Thus, a large number of patients are either not eligible or do not respond to steroids and this group outnumbers those who do respond to steroids, … |
INSTITUTE OF LIVER AND BILIARY SCIENCES INDIA | 2024-04-15 |
| 106 | Comparative- and Cost-effectiveness Research Determining The Optimal Intervention for Advancing Transgender Women Living With HIV to Full Viral Suppression PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Text Me, Alexis! is a three-arm randomized controlled trial (RCT) to determine the optimal and most cost-effective intervention for advancing trans women living with HIV to full viral suppression. Participants will be randomized (1:1:1) to Peer Health Navigation (PHN) alone, SMS (text messaging) alone, or PHN+SMS. Participants in the PHN alone and PHN+SMS arms will receive unlimited navigation sessions over 3 months. Participants in the SMS alone and PHN+SMS arms will receive 3 daily theory-based text messages for 90 days for a total of 270 unique scripted messages. |
CATHY J REBACK; | 2024-04-11 |
| 107 | Fecal Transplantation in Patients With Colonic Diverticulitis: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the safety and effect of fecal microbiome transplantation (FMT) in patients with a former episode of acute colonic diverticulitis. The main question[s] it aims to answer are: – Is FMT in patients with a former episode of acute colonic diverticulitis a safe procedure without severe adverse events – What is the impact of FMT on patient-reported outcomes and re-admission rate Participants will be asked to: – to ingest either 25-30 capsules with FMT or placebo capsules – Fill-in GI-QLI questionnaire prior to treatment/placebo and 3 months post baseline – … |
THOMAS BJØRSUM-MEYER; | 2024-04-01 |
| 108 | The Effect of Maternally Scent-digested Blanket on The Stress Level, Crying Duration and Physiological Parameters of Premature Newborns PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Olfaction is a highly developed and crucial sensory modality that connects the infant and the mother, facilitating the infant’s ability to locate and reach the mother’s breast. the olfactory important sensory ability develops during intrauterine life . By the 11th week of pregnancy, human embryos have completely developed olfactory cells, indicating the complete formation and functionality of the olfactory sensory system during the first trimester . Hence, the olfactory sense undergoes development between the 26th and 28th weeks of pregnancy and, like other senses, … |
SHAHLA SHAFAATI LALEH; | 2024-04-01 |
| 109 | The Ameliorative Effect of C-Kit (+) Hepatic Endothelial Cells With Mertk Deficiency on Nonalcoholic Steatohepatitis Related Papers Related Patents Related Grants Related Experts View Highlight: The prevalence of non-alcoholic fatty liver disease (NAFLD) has been steadily increasing, with 10-20% of affected individuals progressing to non-alcoholic steatohepatitis (NASH). NASH is pathologically characterized by hepatic inflammation, steatosis, and hepatocyte injury. Furthermore, this condition carries a significant risk of progression to advanced hepatic fibrosis (pathological Scheuer fibrosis stage F≥3), cirrhosis, and even hepatocellular carcinoma (HCC). In recent years, NASH has emerged as the leading contributor to the growing burden of cirrhosis worldwide, representing a major public health challenge. Despite the high incidence and clinical severity of NAFLD, there are currently no FDA-approved therapeutic agents for its management. Therefore, … |
SHANGHAI EAST HOSPITAL | 2024-04-01 |
| 110 | Probiotic Supplementation With BLa80, BL21, and LRa05 Stabilizes Lipid Metabolism in Chronic Hepatitis B Patients Receiving Tenofovir Alafenamide: A Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this is to verify the clinical efficacy of compound probiotics in reducing HBV infection levels and regulating intestinal flora in patients with chronic hepatitis B. The main question it aims to answer is: • Conventional antiviral therapy combined with a 3-month probiotic intervention was used to evaluate the clinical efficacy of reducing HBV infection levels (HBeAg, HBsAg, and HBV DNA levels) and regulating gut microbiota. |
WECARE PROBIOTICS | 2024-03-30 |
| 111 | SENOVIE France – Therapeutic Mobility and Breast Cancer PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background In France, there were 61,214 new cases of breast cancer in France in 2023 with an estimated prevalence in 2017 of 913,089 people. It is thus the most common cancer in women, with an incidence that has been increasing since 1990, due both to changes in screening but more recently to a moderate increase in relation to changes in risk factors. Social inequalities in breast cancer are documented, but there are no data on immigrant women, … |
CLÉMENCE SCHANTZ; | 2024-03-25 |
| 112 | Randomized, Double-blind, Placebo-controlled Phase IIa Trial to Evaluate The Efficacy and Safety of Combined/Uncombined Nucleoside (Acid) Analogues of TQA3810 Tablets in Primary/Treated Patients With Chronic Hepatitis B PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and safety of combined/uncombined nucleoside (acid) analogues of TQA3810 tablets. |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2024-03-20 |
| 113 | A Prospective Cross-Sectional Study to Evaluate Diagnostic Sensitivity and Specificity of IStatis HBsAg Test at The Point-Of-Care Site Settings PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective cross-sectional study in which surgically non-invasive sample-taking is done only for the purpose of testing the samples on iStatis HBsAg Test at the point of care. |
BIOLYTICAL LABORATORIES | 2024-03-19 |
| 114 | Re-linking People With Diagnosed But Untreated HCV to Care in A Community-based Substance-use Telemedicine Program PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational, retrospective & prospective cohort study. The retrospective element of the study is a chart review to identify people with diagnosed but untreated HCV and re-link them to care. The observational prospective cohort element of the study will examine the HCV linkage to care, treatment initiation, treatment completion & cure rates of these HCV clients achieved through this chart review and re-linking approach. |
CHRIS CAVACUITI; | 2024-03-12 |
| 115 | Gene-guided N-acetyl Cysteine for Prophylaxis of Anti-tuberculous Drug- Induced Hepatitis: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) remains a significant public health concern in Thailand and globally, especially in tropical regions, with pulmonary TB being predominant. Besides affecting the lungs, TB can also impact extrapulmonary organs. Standard TB treatment involves a combination of drugs administered for at least 6 months, but it can cause adverse effects such as hepatitis. Hepatotoxicity, occurring in 20-60% of patients, is commonly linked to isoniazid, rifampicin, and pyrazinamide. Slow acetylators of the NAT2 gene are particularly susceptible. Previous research suggests N-acetylcysteine (NAC) may mitigate hepatotoxicity, … |
WATCHARASAK CHOTIYAPUTTA; | 2024-03-12 |
| 116 | Quality of Sexual Life of PrEP Users PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will recruit participants on the occasion of their visit in a sexual health center or another HIV pre-exposure prophylaxis (PrEP) facility in France. PrEP users will be proposed to fill a self-administered, online, anonymous questionnaire regarding how they perceive different fields of their sexual life, and how they perceive that PrEP has an impact on the quality of sexual life. |
UNIVERSITY HOSPITAL GRENOBLE | 2024-03-06 |
| 117 | Euro-HDV:Epidemiology and Clinical Course in Patients With HIV and Hepatitis B/D -Coinfection PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this project is to set up a cross-sectional cohort study (France, Germany, The Netherlands, Poland, Spain, Switzerland, Italy, United Kingdom and Portugal) to assess the implementation of EACS guidelines for HDV-testing among PLWH with positive HbsAg and thereby evaluate the prevalence of HDV infection among HIV/HBV-coinfected in 2023, as well as corresponding risk factors. In addition to the testing itself, this study will also set up a cohort and databasee for future HDV studies among PLWH, including clinical, … |
JÜRGEN ROCKSTROH; | 2024-03-01 |
| 118 | Low-Dose Albumin Infusion for The Prevention of Paracentesis Induced Circulatory Dysfunction (PICD), After Large Volume Paracentesis in Decompensated Cirrhosis of Liver PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Abstract for thesis protocol. Background: Paracentesis induced circulatory dysfunction (PICD) is a common complication of large volume paracentesis in cirrhotic patients, which can lead to renal impairment, hyponatremia, and increased mortality. Albumin infusion is recommended to prevent PICD, … |
ABU MD ASADUZZAMAN; | 2024-02-02 |
| 119 | Establishment and Application of A Non-Invasive Dynamic Model for Fibrosis Regression in Patients with Chronic Hepatitis B PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A total of 1000 chronic hepatitis B (CHB) patients with liver biopsy performed at least 1 year after antiviral therapy are retrospectively enrolled. All the patients received NAs treatment. Blood count, liver function test, alpha fetoprotein (AFP), prothrombin time, liver ultrasonography, liver stiffness measurement (LSM), Hepatitis B virus (HBV) DNA and HBV serological markers were collected. HBV-related endpoint events, including cirrhosis decompensations (ascites, esophageal variceal bleeding and hepatic encephalopathy), hepatocellular carcinoma (HCC), … |
SUN YAMENG; | 2024-02-01 |
| 120 | An Outcome Study of Conventional Steroids Vs. Steroids Combined With Mycophenolate for The Management of Newly Diagnosed Immune Thrombocytopenia Purpura: A Cost Effective Measure in Developing Nations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Immune thrombocytopenia Purpura (ITP) is an autoimmune condition delineated by humoral as well as cell mediated immune response against thrombocyte surface proteins GPIIb/IIIa receptors, affecting primary homeostasis leading to mucocutaneous bleeding.ITP is characterized by platelet count <100 x 109/L. The conventional line of treatment for newly diagnosed ITP is steroids but significant disadvantages have been associated with long term use and a high risk of relapse when reducing the dose. The addition of MMF to the first line treatment of ITP resulted in substantial response and a lower risk of refractory ITP with decreased financial burden and improved outcome. |
RUKH-E- ZAINUB; | 2024-02-01 |
| 121 | Safety and Effectiveness of Sulfasalazine in The Treatment of Liver Fibrosis/Cirrhosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a controlled, observational clinical study initiated by investigators to investigate the efficacy and safety of sulfasalazine in the treatment of cirrhosis in patients with cirrhosis. Four cohorts were planned: primary biliary cirrhosis, hepatitis B and C cirrhosis, and alcoholic cirrhosis. The four groups were divided into experimental group and control group, and the experimental group: each group of patients was orally treated sulfasalazine for 12 months, taken three times a day, each time taking 0.5g. The control group did not take sulfasalazine. After 12 months, Observe changes in patients’ biochemical and imaging indicators, liver stiffness values, fecal microbiota, … |
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY | 2024-02-01 |
| 122 | Effect of Gentle Human Touch and Kangaroo Care Applied During Hepatitis-B Vaccination in Newborns on Pain, Crying Duration and Physiological Parameters: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many short- and long-term consequences, including altered physiological parameters, issues with feeding and sleep, chronic pain syndrome, difficulty focusing, anxiety, cognitive behavioral disorders, adjustment disorders, and growth retardation, have been linked to pain in neonates. Each and every newborn is entitled to pain relief and reduction. Avoiding painful interventions is the most crucial tactic in the management of newborn pain. However, it is impossible to ignore the necessity of therapeutic and diagnostic interventions. As such, pain reduction and elimination are crucial. Non-pharmacological techniques used on infants undergoing invasive operations have been shown in studies to be successful in reducing discomfort, … |
ELIF TUBA KOC; | 2024-02-01 |
| 123 | Integrated Precision Imaging for Immune-related Adverse Events: Hyperpolarized 13C-MRI and Metabolomics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project investigates immune-related adverse events (irAEs) in cancer patients treated with immune checkpoint inhibitors (ICIs), focusing on metabolic changes. It explores how glucose metabolism in the spleen, which mirrors immune activity, might predict irAEs. Using advanced imaging like hyperpolarized (HP) 13C-MRI and metabolomics, the study aims to detect metabolic flux in the spleen, potentially offering early prediction and risk categorization of irAEs. The 3-year study will involve 30 cancer patients on ICIs, comparing those with and without irAEs. It hypothesizes that splenic metabolic alterations seen in HP 13C-MRI can forecast and categorize irAE severity, … |
YING-CHIEH LAI; | 2024-02-01 |
| 124 | Efficacy and Safety of Avatrombopag Vs. Avatrombopag Combined With RhTPO in The Treatment of Patients With Severe Aplastic Anemia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Title: Efficacy and safety of Avatrombopag VS Avatrombopag combined with rhTPO in patients with severe aplastic anemia: a single-center, controlled study Observation group: Patients with severe aplastic anemia who did not respond to initial treatment (unconditional HSCT or ATG) or other treatments (except HSCT) Objective: To evaluate the efficacy and safety of Avatrombopag and rhTPO in the treatment of patients with severe aplastic anemia, to provide more treatment options for patients with severe aplastic anemia who are unable to undergo transplantation /ATG or have failed previous treatment, … |
INSTITUTE OF HEMATOLOGY & BLOOD DISEASES HOSPITAL CHINA | 2024-02-01 |
| 125 | Find HDV and Determıne Its Status in Turkey SITU(HD)VATION PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of these study to determine the prevalence of HDV infections and the prognosis of HDV patients in Turkey’s southeast. We intend to arrange training sessions for 250 family physicians in Diyarbakır, Batman, Mardin, and Şanlıurfa in order to determine those goals. We will talk about diagnosing HBV, HDV, HCV, and HIV infections during these events. To ensure that patients with simultaneous HDV infection are evaluated for HIV/HCV and to detect liver fibrosis with a non-invasive method. |
YASAR BAYINDIR; | 2024-01-31 |
| 126 | TherVacB_Phase1a: Open Phase 1a Trial to Assess The Safety and Immunogenicity of A Heterologous Protein Prime/MVA Boost Therapeutic Hepatitis B Vaccine Candidate in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an open-label, ascending dose phase 1a trial to assess the safety and immunogenicity of a heterologous protein prime/MVA boost therapeutic hepatitis B vaccine |
MARYLYN M ADDO; | 2024-01-23 |
| 127 | Characteristics and Risk Factors for Invasive Fungal Infection in Hospitalized Patients With Acute-on-chronic Hepatitis B Liver Failure: A Retrospective Cohort Study From 2010 to 2023 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center retrospective study. The clinical data of patients with Acute-on-chronic Hepatitis B liver failure who were hospitalized in the Department of Hepatology, Qilu Hospital of Shandong University from January 2010 to July 2023 were collected. |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2024-01-20 |
| 128 | The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia (A Randomized Controlled Clinical Trial With A Biochemical Assessment) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is designed to evaluate the clinical efficacy of thyme honey as a mouth rinse in the management of polypharmacy-induced xerostomia concerning the unstimulated whole salivary flow rate and quality of life of patients along with a biochemical assessment of salivary nitric oxide levels. |
NEVEN NABIL TADRY BANOUD; | 2024-01-15 |
| 129 | Using Shared Decision Making to Improve Kidney Transplantation Rates PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to increase shared decision-making between dialysis providers and patients in order to increase patients’ probability of transplantation and to reduce socioeconomic/racial disparities in access to kidney transplantation. Participants will receive educational material over the course of 4-6 months about different aspects of the kidney transplant and waitlisting process. |
SUMIT MOHAN; | 2024-01-12 |
| 130 | A Multi-center, Randomized, Double-blind, Placebo-controlled Phase Ib Clinical Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 162 With A Single Ascending Dose in Subjects With Chronic Hepatitis B Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this intervention research is to learn about the safety and tolerability of 162 with a single ascending dose in subjects with chronic hepatitis B virus (HBV) infection. |
YANGSHENGTANG | 2024-01-12 |
| 131 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Study to Evaluate The Efficacy and Safety of RZ358 in Patients with Congenital Hyperinsulinism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Phase 3 pivotal study is designed to evaluate the efficacy and safety of RZ358 for the treatment of congenital hyperinsulinism (HI) as add-on to standard-of-care (SOC) therapy compared to SOC alone over 24 weeks and to evaluate the longer-term safety and efficacy of RZ358 during a subsequent open-label extension (OLE) period. |
REZOLUTE | 2024-01-11 |
| 132 | Comparing Nutritional Interventions in Patients With Alcohol-associated Hepatitis: A Randomized Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Alcohol-associated hepatitis (AH) is a life-threatening condition with high 90-days mortality (up to 40%) and limited treatment options. Previous studies have shown that decreased nutritional intake (less than 21 kcal/kg/day) is associated to a higher mortality compared to patients with a higher caloric intake. Additionally, it has been suggested that subjects with severe AH, should receive a high-protein diet, however, no specific trials have been carried out to address these questions. Thus, … |
JUAN-PABLO ARAB; | 2024-01-01 |
| 133 | A Multicenter, Double-blind, Placebo-randomized Controlled Clinical Study on The Treatment of Non-alcoholic Steatohepatitis With Tibetan Drug Langqing Atar PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: non-alcoholic steatohepatitis (NASH) is an inflammatory liver disease caused by the accumulation of fat in liver cells. With the change of living habits and diet, the incidence of Nash continues to increase. In the early stage, NASH generally has no obvious symptoms. With the progression of the disease and the aggravation of liver damage, it may induce fatigue, loss of body mass, and pain in the right upper abdomen, which seriously affects the health of patients. There are no specific drugs to treat NASH in clinical practice. Increasing exercise, taking drugs to avoid liver damage, … |
SHUPEI LI; | 2024-01-01 |
| 134 | Bloody or Well Done. How Would You Like Your Liver Biopsy, Sir? Post Liver BIopsy AbdoMinal PaIn As Predictive Factor for Liver BleeDing (LIMPID) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized comparative trial between percutaneous liver biopsy and EUS FNB guided liver biopsy in patients with parenchymal liver disease. Studies so far have been shown that EUS FNB guided liver biopsy is non inferior to percutaneous liver biopsy in terms of efficacy, provided several conditions are met (type of needle, wet suction, actuations). În terms of safety, it may be that EUS FNB have an advantage, as needle diameter is slightly smaller, … |
MIHAI CIOCIRLAN; | 2024-01-01 |
| 135 | A Study on The Relative Bioavailability of HR19042 Capsules in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, randomized, open-label, three-period, dual Latin square crossover study. Primary Objective： 1. To evaluate the oral relative bioavailability of HR19042 Capsules compared with budesonide delayed-release capsules (Tarpeyo®) and budesonide enteric-coated capsules (Budenofalk®). Secondary Objective 2. To assess safety following administration. |
JIANGSU HENGRUI MEDICINE | 2023-12-27 |
| 136 | National Liver Cancer Screening Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible patients will be randomized in a 1:1 fashion to Arm A using semi-annual ultrasound and AFP-based screening or Arm B using semi-annual screening using GALAD alone. Randomization will be stratified by sex, enrolling site, Child Pugh class (A vs. B), and HCC etiology (viral vs. non-viral). Patients will be recruited from 15 sites (mix of tertiary care and large community health systems) over a 3-year period, … |
AMIT SINGAL; | 2023-12-26 |
| 137 | A Randomized, Double-blind, Placebo-controlled Phase IIa Clinical Study to Evaluate The Safety and Efficacy of GST-HG131 Tablets in Patients With Chronic Hepatitis B PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Change from Baseline in HBsAg levels Number of participants with adverse events (AEs), serious adverse events (SAEs), and withdrawals due to AEs … |
FUJIAN AKEYLINK BIOTECHNOLOGY | 2023-12-26 |
| 138 | Immunogenicity and Safety of Inactivated Hepatitis A Vaccine in HIV-infected People Aged 1-40 Years: A Phase IV Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Approximately 400 HIV-infected participants aged 1-40 years old will be recruited according to the inclusion and exclusion criteria. Among them, more than 180 participants will be recruited in the immunogenicity and safety study. Each of them will receive 2 doses of HAV vaccines with a 6-month interval. Blood samples will be drawn before and 1 month after each dose to detect the HAV anitibodies to evaluate the immunogenicity of the vaccines. Other people will be recruited in the safety study and receive at least one dose of HAV vaccine. All the participants will report the adverse events within one month after each dose. |
ZHONGSHENG JIANG; | 2023-12-19 |
| 139 | Randomized Controlled Trial of Glecaprevir/Pibrentasvir for The Treatment of Post-traumatic Stress Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A double-blind randomized placebo-controlled trial to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with posttraumatic stress disorder (PTSD) symptom improvement when prescribed for the treatment of chronic hepatitis C viral infection (HCV). |
BRADLEY WATTS; | 2023-12-18 |
| 140 | Determination of HEV Seroprevalence Among Blood Donors in Occitania PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the proposed work is to determine the seroprevalence of HEV in 2023 in a population of blood donors living in Occitania. Compare the current frequency of anti-HEV IgG and IgM markers with that of 2011. The serological techniques used and the questionnaires will be similar |
JACQUES IZOPET; | 2023-12-15 |
| 141 | Adult Screening for Hepatitis C and Linkage to Treatment in Hospitals in Colombia PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Hepatitis C virus infection is a major cause of chronic hepatitis, cirrhosis, and liver cancer. The risk of developing cirrhosis for people with chronic infection with the virus ranges from 15% to 30% over a 20-year period. According to 2019 data from the World Health Organization there are 58 million people living with chronic hepatitis C infection. Three-quarters of those infected live in low- to middle-income countries, some of which lack budgets for screening, diagnosis and treatment campaigns. While good progress has been made in several countries, … |
DIANA ROCIO CHAVEZ BEJARANO; | 2023-12-11 |
| 142 | A Clinical Trial to Evaluate The Safety and Immunogenicity of A Single Dose of Adsorbed Tetanus Vaccine in A Population Aged 18 Years and Over PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, observer-blind, positive-controlled study. There will be 2 treatment groups, Subjects who gave informed consent and passed the questioning screen were randomly assigned 1:1 to be immunized with 1 dose of Tetanus Vaccine, Adsorbed (TTVA) or control vaccine. |
SHIGUANG LEI; | 2023-12-01 |
| 143 | Risk Factors of Thrombocytopenia In Chronic Kidney Disease And Hemodialysis Patients In Assiut University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: factors contributing to thrombocytopenia in ESRD include uremia, blood loss, sepsis, and heparin treatment (2). Haemodialysis (HD) has been also identified as a potential cause of thrombocytopenia due to the interaction of dialysis membranes with platelets, triggering adhesion, aggregation, and activation. Renal replacement therapy has improved in recent decades, particularly with the use of synthetic and highly biocompatible dialyzer membranes. During hemodialysis treatment, patients are exposed to a variety of components of the dialysis circuit and thrombocytopenia is not uncommon |
AYA ATA KAMEL; | 2023-12-01 |
| 144 | A Study to Evaluate The Safety and Immunogenicity of A Single Dose of Adsorbed Tetanus Vaccine in A Population Aged 18 Years and Over PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, observer-blind, positive-controlled study. There will be 2 treatment groups, Subjects who gave informed consent and passed the questioning screen were randomly assigned 1:1 to be immunized with 1 dose of Tetanus Vaccine, Adsorbed (TTVA) or control vaccine. |
SHIGUANG LEI; | 2023-12-01 |
| 145 | Efficacy of Manuka Honey Oral Rinse in Treatment of Xerostomia in Elderly: A Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Xerostomia causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food thus may affect the individual’s quality of life, therefore this study aimed to evaluate the clinical effectiveness of Manuka honey mouth rinse using the subjective dry mouth score, and patient satisfaction as primary objectives and to assess the effect of Manuka honey on the salivary flow rate, and objective dry mouth score as secondary objectives. |
BRITISH UNIVERSITY IN EGYPT | 2023-12-01 |
| 146 | New Biomarkers of HBV Infection: Clinico-Biological Characterization and Impact on Infection Management PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Hepatitis B Virus (HBV) infection affects nearly 300 million people worldwide and is a leading cause of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). In France, it affects around 0.3% of the population. Current clinical practice relies on traditional biomarkers, such as HBV DNA and HBsAg, to monitor viral replication and disease progression. However, these biomarkers do not fully capture the viral activity or predict clinical outcomes. Recently, new biomarkers like HBcrAg and HBV RNA have emerged, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-11-28 |
| 147 | Role of Extended Low Dose Prednisolone in Achieving Clinical and Biochemical Remission in Steroid Responsive Severe Alcoholic Hepatitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Severity of alcoholic hepatitis is defined by Maddrey’s discriminant function, value of 32 or higher indicates severe alcoholic hepatitis that carries an adverse prognosis with one month mortality of 30%-50%. Prednisolone (40 mg/day) given orally should be considered to improve 28-day mortality in patients with severe AH. Abstinence is key to long-term survival. According to current protocol, … |
INSTITUTE OF LIVER AND BILIARY SCIENCES INDIA | 2023-11-25 |
| 148 | A Phase IIc, Open-Label, Randomized Controlled Trial of Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible Tuberculosis (PRESCIENT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The PRESCIENT trial is a Phase IIc, open-label, randomized trial that will compare a 12-week regimen of bedaquiline (BDQ), clofazimine (CFZ), pyrazinamide (PZA), and delamanid (DLM) with standard treatment for drug-susceptible pulmonary tuberculosis. Eligible participants will be randomized in a 1:1 ratio to BDQ, CFZ, PZA, … |
SERENA PATRICIA KOENIG; | 2023-11-24 |
| 149 | The Impact Of Sodium-Glucose Cotransporter 2 Inhibitors on Metabolic Dysfunction -Associated Steatotic Liver Disease In Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study question 1:Could SGLT2-I improve hepatic fibrosis, steatosis, and inflammatory markers in type 2 diabetic patients with Metabolic associated steatotic liver disease Question 2:Which drug of SGLT2-I group is more effective in improving metabolic associated steatotic liver disease in type 2 diabetic patients? |
GEORGE ESMAT ROSHDY; | 2023-11-15 |
| 150 | Prevalence of Depressive Disorders and Anxiety Disorders Among Sample of Patients With Chronic Liver Disease Attending Assiut University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this observational study is to learn about the prevalence of depressive and anxiety disorders among patients with chronic liver diseases |
SALMA ASHRAF MOHAMED BADR; | 2023-11-01 |
| 151 | The Value of CircRNAs (hsa_circ_0004001) in Early Diagnosis of HCC PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To evaluate the clinical utility of plasma circRNAs (hsa_circ_0004001) as a non invasive diagnostic biomarker for HCC patients and to differentiate between malignant and nonmalignant hepatic disorders. 2. To study the relation of circRNAs (hsa_circ_0004001) to HCC staging. 3. To compare between circRNAs (hsa_circ_0004001) and the routine marker (AFP) as biomarkers for HCC diagnosis. |
MARWA ABOELIM SHAFEIK; | 2023-11-01 |
| 152 | Continuous Glucose Monitoring As A Strategy to Optimize Metabolic Control in Patients With Diabetes on Peritoneal Dialysis Therapy Entitled to The IMSS PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The patient presenting Chronic Kidney Disease, with etiology of diabetes mellitus (DM), has a metabolic alteration characterized by an elevation of glycemia and accompanied by cardiovascular complications, this increases the morbidity and mortality associated with the disease. Therefore, it is necessary to maintain adequate metabolic control to reduce the incidence of these complications. This task is extraordinarily difficult without the use of Icodextrin due to the optimal adjustment of insulin, due to the additional supply of glucose contained in the Dialysis Bosas and which is absorbed through the peritoneum. Under this premise, … |
COORDINACIÓN DE INVESTIGACIÓN EN SALUD MEXICO | 2023-11-01 |
| 153 | Improving Vaccine Counseling Skills Among Pediatric, Medicine/Pediatric and Family Medicine Residents Pilot Study: Evaluation, Education, and Promotion of Vaccine Confidence Using Educational Modules and Standardized Patient Encounters PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Unfortunately, only 40% of US pediatric residency programs reported in a survey that vaccine safety and counseling training is provided to residents. The success of a residency curriculum focused on communication strategies with patients hesitant to receive the influenza vaccine has been demonstrated, finding a decreased rate of vaccination refusal in the post curricular period. In a recent 2020 study, … |
ANDREA HERNANDEZ-TROYA; | 2023-11-01 |
| 154 | Single-cell Landscape of Immunological Responses in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to profile the peripheral blood immune cells of patients with HBV related acute-on-chronic liver failure using single-cell RNA sequencing to reveal the immunopathological mechanisms of HBV related acute-on-chronic liver failure. |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2023-11-01 |
| 155 | Randomized, Double-blind, Placebo-controlled Phase Ib/IIa Clinical Trial to Evaluate The Efficacy and Safety of TQA3605 Tablets Monotherapy or in Combination With Nucleoside (Acid) Analogues in Treatment-naïve Patients and Treated Patients With Chronic Hepatitis B PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind Phase Ib/IIa multicenter trial. All eligible subjects will receive TQA3605 tablets or placebo in combination with nucleoside (acid) analogues. A total of 64 subjects will be enrolled. |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2023-11-01 |
| 156 | Hepatitis A Virus Induced Acute Acalculous Cholecystitis Diagnosed Postoperatively: Case Report Related Papers Related Patents Related Grants Related Experts View Highlight: 41-year-old previously healthy patient presented with right upper quadrant abdominal pain. Pain started two days prior to presentation when an abdominal ultrasound in a peripheral hospital showed a 10 mm gallbladder stone with normal laboratory tests; however, her pain was resolved on analgesics. Now the pain was persistent and associated with vomiting and laboratory tests showed elevated bilirubin. Laparoscopic cholecystectomy with intraoperative cholangiography was done that showed inflamed gallbladder but with no stones and normal cholangiography. Day one post-operation, while the pain resolved, … |
OMAR TABBIKHA; | 2023-11-01 |
| 157 | Prevalence of Seroconversion of Hepatitis C Virus Among Children With Chronic Kidney Disease on Regular Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: observational cross sectional study for children with chronic kidney disease who on regular hemodialysis in assiut univeristy children hospital at dialysis unit, observe prevalence of serological seroconversion of hepatitis c virus and associated risk factors |
MAHMOUD MOHAMED ZEAWELA; | 2023-10-26 |
| 158 | Randomized Crossover Diet Study Comparing Impact of Mediterranean Diet to Western Diet on Fatigue in Autoimmune Hepatitis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, proof-of-concept pilot study which uses a cross-over design to compare two dietary interventions/treatments: Western Diet (WD) vs Mediterranean (MD) and impact on quality-of-life parameters in AIH. Participants will receive both treatments through two phases and will be divided into two groups. |
CRAIG LAMMERT; | 2023-10-23 |
| 159 | A Descriptive Study on Patterns of Persistent Neonatal Jaundice on Neonates and Children at Assiut University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Describe demographic and clinical data of neonates & childern with (PNNJ) admitted to neonatology , hepatology & hematology units of Assiut university children hospital(AUCH). Describe the distribution of etiologies of (PNNG) in neonates & children at AUCH. Assess the outcome of (PNNJ) in neonates & childern admitted to AUCH . |
ELHAM ALLAM AHMED ABD ELKARIM; | 2023-10-13 |
| 160 | A Controlled, Observed Trial of Hepatitis C Self-Testing in The Hands of Untrained Lay Users PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a controlled study intended to evaluate the usability, label comprehension and performance of the INSTI® HCV Self Test in the hands of untrained lay users using fingerstick blood, with instructions for use specifically designed for a lay person who has not used any hepatitis C rapid self test prior to the study and to assess lay users ability to comprehend key concepts and information provided on the outside of the pouch and in the accompanying Instructions for Use. Comprehension will be assessed without product familiarization (demonstration/training) by a healthcare professional. |
MOHAMMED MAJAM; | 2023-10-12 |
| 161 | INSTI® HCV (Hepatitis C Virus) Antibody Self-Test Contrived Result Interpretation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this Interpretation Assessment was to document if lay people, non-professional and inexperienced in self-testing, were able to successfully perform the steps to use a Hepatitis C Virus (HCV) Self-Test (HCVST) device, without product familiarization [demonstration]. |
BIOLYTICAL LABORATORIES | 2023-10-12 |
| 162 | The Role Of Laserpuncture For Prevention Of Nausea And Vomiting Post Strabismus Surgery With General Anesthesia In Adult Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study to determine the effectiveness of a combination of pre-surgical laserpuncture with standard anti-emetic therapy for PONV symptoms in adult patients after strabismus surgery under general anesthesia compared to a combination of pre-surgical placebo laserpuncture with standard anti-emetic therapy. Research design using a double blinded randomized controlled trial (RCT) where research subjects and data takers who will be disguised. The research will be carried out in the Operation and Inpatient Room, Kirana Building, … |
YOSSIE FAUDINA PUTRI; | 2023-10-09 |
| 163 | An Implementation Trial of Continuous Quality Improvement for Antenatal Syphilis, HIV and Hepatitis B Detection and Treatment in Indonesia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Elimination of mother-to-child-transmission (EMTCT) of HIV, syphilis and hepatitis B are key priorities in Indonesia, the fourth most populous country in the world. Despite national guidelines and strong antenatal care attendance, … |
YANRI WIJAYANTI SUBRONTO; | 2023-10-01 |
| 164 | A Non-invasive Model to Predict Antiviral Therapy in Patients With Gray Zone of Chronic Hepatitis B: A Multi-center, Retrospective Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Establishment and validation of the non-invasive model to predict antiviral therapy in the gray zone of chronic hepatitis B |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2023-10-01 |
| 165 | A Prospective, Trial About Safety and Efficacy of Combined Treatment With Cerebrolysin in Acute Ischemic Hemispheric Stroke Patients Undergoing EndoVascular Treatment (EVT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is investigate the efficacy of a neuro/vascular-protective treatment with the drug Cerebrolysin in patients with acute ischemic stroke. starting immediately after completion of a EVT therapy. The main question the study aims to answer is: If a 10 days treatment with the neuro/vascularprotective drug Cerebrolysin (30 ml/day as intravenous infusion) is able to increase the overall outcome of EVT therapy? Participants will receive intravenous treatment with Cerebrolysin (30 ml/day) starting immediately after thrombolytic therapy and being continued for 10 consecutive days as one single daily infusion. The modified Rankin Scale (mRS) 90 days after onset of symptoms will be investigated, but also the improvement in other ratings as well as the time course of the improvement. In addition to the clinical outcome measures the study will assess neuroimaging perfusion CT-Perfusion parameters to evaluate possible direct improvement in microcirculation that might be an additional mechanism of action of cerebrolysin. CT-Perfusion being done immediately after EVT will provide ability to stratify the data according to non-favorable CT-Perfusion parameters after EVT versus favoravle. |
RONI EICHEL; | 2023-10-01 |
| 166 | Comparison of Biofilm Accumulation on The Surface of Zirconia Versus Titanium Implants. Randomized Controlled Pilot Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized clinical trial is to compare the amount and type of biofilm formed on the surface of zirconia implants compared to titanium implants. A pilot randomized clinical trial will be conducted in which 15 zirconia and 15 titanium single implants will be placed in different patients and the amount of total biofilm and different bacterial species will be evaluated at 3, 6 and 12 months after placement, in addition to bleeding on probing, plaque index, amount of keratinized gingiva, … |
UNIVERSIDAD COMPLUTENSE DE MADRID | 2023-10-01 |
| 167 | A Pilot / Feasibility Study of Autologous CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine in Patients With Intermediate or High Grade B-Lineage Non-Hodgkin Lymphoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase I trial studies the safety and feasibility of cytomegalovirus (CMV) specific CD19-chimeric antigen receptor (CAR) T cells in combination with the CMV-modified vaccinia Ankara (MVA) triplex vaccine following lymphodepletion in treating patients with intermediate or high grade B-cell non-Hodgkin lymphoma (NHL) that has come back after a period of improvement (relapsed) or that does not respond to treatment (refectory). CAR T cells are a type of treatment in which a patient’s T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added in the laboratory. The special receptor is called CAR. Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion. Vaccines such as CMV-MVA triplex are made from gene-modified viruses and may help the body build an effective immune response to kill cancer cells. Giving CMV-specific CD19-CAR T-cells plus the CMV-MVA triplex vaccine may help prevent the cancer from coming back. |
LESLIE L POPPLEWELL; | 2023-09-29 |
| 168 | Pattern of Autoimmune Hepatitis in Children In Sohag University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder of unknown etiology. If left untreated, it progresses to liver cirrhosis and liver failure. Diagnosis of AIH relies on the exclusion of other causes of liver disease and the presence of positive clinical, biochemical, and histological criteria. AIH has a very wide spectrum of clinical presentations ranging from being asymptomatic to an acute severe fulminant disease. It may be associated with other autoimmune disorders such as thyroiditis, type 1 diabetes, vitiligo, inflammatory bowel disease, or juvenile idiopathic arthritis. Biochemical features of AIH include elevation of serum alanine aminotransferase (ALT), … |
FATHY MOHAMED ABDELHAKAM; | 2023-09-10 |
| 169 | Integrated Antenatal Screening for HIV, Syphilis, and Hepatitis B Virus (HBV) in Pregnant Women in Burkina Faso and The Gambia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The TRI-MOM program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple elimination of HIV, syphilis and HBV mother-to-child transmission (MTCT) in nine maternal and child health services, 5 in Burkina Faso and 4 in The Gambia. The TRI-MOM program has two components: 1. an intervention component consisting of a pilot study to reinforce the antenatal screening and prevention of MTCT (PMTCT) capacities for the 3 targeted infections through the implementation of a simplified, … |
SYLVIE BOYER; | 2023-09-01 |
| 170 | Efficacy of Accelerated Versus Standard Regiment of Hepatitis B Virus Vaccine Among Inflammatory Bowel Disease Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that includes ulcerative colitis (UC) and Crohn’s disease (CD) . They mainly affect young populations, altering their quality of life and increasing morbidity, compared to the general population . The etiology and pathogenesis of IBD are still poorly understood. Inflammatory bowel disease (IBD) patients are at an increased risk of contracting and developing complications from hepatitis B virus (HBV) due to their weakened immune systems and frequent use of immunosuppressive medications. The traditional HBV vaccine regimen requires three doses over six months to achieve full immunity, … |
MARIA SABRY; | 2023-09-01 |
| 171 | Patient Knowledge, Beliefs and Barriers to Hepatitis D Care; Single Site Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A project to understand the determinants of health behaviour among those with chronic hepatitis D virus (HDV) infection, under the care of the viral hepatitis service at Kings College Hospital (KCH). This is to improve and implement pathways and patient information distribution to improve access to care in an ethnically diverse population living with HDV in the UK. Kings college hospital NHS Foundation Trust is uniquely placed and serves a large diverse population from areas such as pan pacific Asia, Eastern Europe and regions in Africa, … |
KING’S COLLEGE HOSPITAL NHS TRUST | 2023-09-01 |
| 172 | Pulmonary Function Tests Study in Cirrhotic Patients With and Without Hepatocellular Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cirrhosis is a terminal image of chronic liver disease. During the progression from the compensation period to the decompensation period, various complications occur, and the life prognosis is significantly reduced. In recent years, medical treatment for liver cirrhosis has made marked progress. Liver cirrhosis may occur as an end result of manifold infectious, toxic, metabolic, or autoimmune conditions such as viral hepatitis, alcoholism, non-alcoholic steatohepatitis, autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), or a variety of storage disorders such as hemochromatosis, Wilson’s disease, and alpha-1-antitrypsin deficiency. Worldwide, … |
YOUSSEF MOHAMED MAHMOUD; | 2023-09-01 |
| 173 | A Prospective, Observational Clinical Study to Evaluate The Incidence of Viral Hepatitis D Relapses Upon Discontinuation of Antiviral Therapy With Bulevirtide in Patients With Chronic Hepatitis D and Negative HDV RNA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational study will be conducted in patients with chronic co-infection with hepatitis B and D viruses, with negative PCR for HDV RNA in peripheral blood and no signs of active liver inflammation according to blood chemistry parameters, receiving background therapy with bulevirtide for more than 48 weeks and liver biopsy performed or prescribed to be performed as part of routine practice. After the patient has signed the Informed Consent, a portion of the liver biopsy collected as part of routine practice will be sent to the laboratory for PCR testing for HDV RNA, … |
CENTER OF TARGET THERAPY | 2023-09-01 |
| 174 | Patterns of Hemophilia Care in Patients Admitted in Assiut Children University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hemophilia A and B are congenital, recessive X-linked disorders caused by lack or deficiency of clotting factor VIII (FVIII) or IX (FIX), respectively. The severity of the disease depends on the reduction of levels of FVIII or FIX, which are determined by the type of the causative mutation in the genes encoding the factors (F8 and F9, respectively). The hallmark clinical characteristic, especially in untreated severe forms, is bleeding (spontaneous or after trauma) into major joints such as ankles, knees and elbows, … |
SARA AHMED ABD EL-BARY; | 2023-09-01 |
| 175 | Efficacy and Safety of Switching to Vemliver (Tenofovir Alafenamide) From Entecavir in Chronic Hepatitis B: A Multi-Center, Phase IV, Open-Label, Randomized, Active-Controlled, Non-Inferiority Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Enroll patients who are pre-treated with Entecavir at least 24 weeks and confirmed HBV antiviral (HBV DNA \<69 IU/mL) effects. Subjects are given one test drug or comparator once a day for 48 weeks according to the results of random assignments, and their HBV antiviral inhibitory effect and safety are evaluated at 24 and 48 weeks visits. |
YOON JUN KIM; | 2023-08-28 |
| 176 | A Phase I Trial of Anti-CD19 and Anti-CD20 Bicistronic Chimeric Antigen Receptor T- Cells for Treating B-cell Malignancies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: About 23,000 people die from B-cell cancers in the US each year. These cancers, often called leukemia or lymphoma, affect a type of white blood cell called B cells. These cancers are difficult to treat, and the therapies used can have bad side effects. Researchers want to try a new type of treatment. This new treatment uses a patient s own immune cells (T cells) that are modified to carry genes (chimeric antigen receptor, … |
JAMES N KOCHENDERFER; | 2023-08-28 |
| 177 | A Randomized, Double-Blind, Placebo-Controlled, Safety, and Efficacy Study of Plant Based Biotin and Plant Based Biotin with Silica in Healthy Adult Human Subjects with Complaints of Hair Fall Thin, Dry, & Brittle Hair, and Dry Skin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, double-blind, three-arm, placebo-controlled, safety, and efficacy study of plant-based Biotin and plant-based Biotin with Silica in healthy adult human subjects with complaints of hair fall, thin, dry, and brittle hair, and dry skin. A sufficient number (maximum of 105 (35 subject/test treatment)) of female/male adult subjects will be recruited/enrolled to ensure a total of 96 subjects (32 subjects/test treatment) complete the study. |
NAYAN PATEL; | 2023-08-22 |
| 178 | Key Population-Led Same Day Test and Treat for Hepatitis C in Community-Based Organizations in Bangkok, Thailand: A Demonstration Project PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Hybrid design to primarily assess effectiveness, and to secondarily observe and collect data on the implementation of the service. This will allow the assessment of health-related outcomes and implementation outcomes to facilitate dissemination and replication if proven to be successful in other CBOs in Thailand, regionally, and globally. |
INSTITUTE OF HIV RESEARCH AND INNOVATION FOUNDATION THAILAND | 2023-08-17 |
| 179 | Effects of Phytosterol Supplementation on Serum Lipid Profile, Liver Enzymes, Insulin, Adiponectin, and Inflammatory Status in Patients with Nonalcoholic Fatty Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-alcoholic fatty liver disease (NAFLD) is considered one of the most common chronic liver diseases worldwide, it recently became a worldwide problem with high morbidity which requires further attention. The use of natural bioactive products such as phytosterols have shown anti-NAFLD effect with little to no side effects when used as a supplement in the therapeutic protocol of NAFLD, in many animals, and In vitro studies. Although the positive impacts of phytosterols on the prevention of hypercholesterolemia and improving liver functions have been reported in previous studies, further clinical experiments, … |
SHATHA HAMMAD; | 2023-08-15 |
| 180 | Acalabrutinib Real World Italian ObSErvational Secondary Data Collection Study of Acalabrutinib in The Treatment of Patients With Chronic Lymphocytic Leukemia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the adults in the Western world, with an annual incidence of approximately 5 cases per 100,000 inhabitants in Italy. Acalabrutinib (CalquenceTM), a selective second-generation Bruton Tyrosine Kinase (BTK) inhibitor developed by AstraZeneca, has been assessed for the treatment of CLL in three phase III clinical trials, ELEVATE-TN (treatment-naïve CLL), … |
CAROLA BOCCOMINI; | 2023-08-08 |
| 181 | A Phase 3, Open-Label Extension Study to Evaluate The Long-Term Safety and Efficacy of Fazirsiran in Participants With Alpha-1 Antitrypsin Deficiency-Associated Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of this study is to learn if fazirsiran is safe during long-term use in people with liver disease caused by the abnormal Z-alpha-1 antitrypsin (Z-AAT) protein. People who have taken part in previous fazirsiran studies (AROAAT2001 \[NCT03945292\] or AROAAT2002 \[NCT03946449\]) can continue to receive fazirsiran every 3 months as long as they participate in this study, … |
TAKEDA | 2023-08-08 |
| 182 | National Prisons Hepatitis Education Project: Research Evaluation PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The National Prisons Hepatitis Education Program (HepPEd Program) is a national, prison-based hepatitis C health literacy education program for healthcare providers, correctional officers, and people in prison. The HepPEd Program aims to improve the public health literacy of the prison sector regarding hepatitis C in prisons. The HepPEd: Research Evaluation aims to evaluate the impact of the HepPEd Program on HCV testing and treatment uptake amongst people incarcerated in Australian prisons, as well as changes in knowledge, attitudes, and capabilities of healthcare providers, correctional officers, … |
KIRBY INSTITUTE | 2023-08-01 |
| 183 | Effect Of Reusing The Operative Supplies On Cataract Surgery and Climate Change PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Although postoperative infectious endophthalmitis and toxic anterior segment syndrome (TASS) rarely happen, they can threaten sight and are considered complications of intraocular and cataract surgery1. Reusing surgical supplies during cataract surgery, especially in developing countries, will have a treble impact in lowering the financial costs of surgery, the emissions of greenhouse gas, and environmental waste. Nearly half the waste of cataract surgery is recyclable, as reported by a prospective Malaysian study 8. Despite the increasing evidence of reusing the operative supplies, … |
HANY MAHMOUD; | 2023-08-01 |
| 184 | Improving Physician Vaccine Recommendation Using Social Norms, Trust, and Presumptive Language PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research examines vaccination recommendation perceptions and behaviors of physicians and advanced practice providers. |
DAN ARIELY; | 2023-08-01 |
| 185 | A Randomized, Double-blind, Placebo-controlled Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses of CB06-036 in Subjects With Chronic Hepatitis B PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: CB06-036 is an investigational drug developed by Shanghai Zhimeng Biopharma Inc. for the treatment of Chronic Hepatitis B. |
SHANGHAI ZHIMENG BIOPHARMA | 2023-08-01 |
| 186 | A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-designed Phase II Study to Evaluate The Efficacy and Safety of HRS9950 Tablets in Chronic Hepatitis B Patients Who Are Virologically Suppressed on Nucleoside or Nucleotide Analogues (NAs) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and safety of HRS9950 tablets in chronic hepatitis B patients who are virologically suppressed on nucleoside or nucleotide analogues (NAs). |
CHENGDU SUNCADIA MEDICINE | 2023-08-01 |
| 187 | Pilot/Feasibility Study of CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Following Autologous Hematopoietic Stem Cell Transplantation for Patients With Intermediate or High Grade B-Lineage Non-Hodgkin Lymphoma (B-NHL) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase I trial studies the safety and side effects of cytomegalovirus (CMV) specific CD19-chimeric antigen receptor (CAR) T-cells along with the CMV-modified vaccinia Ankara (MVA) triplex vaccine following a stem cell transplant in treating patients with high grade B-cell non-Hodgkin lymphoma. CAR T-cells are a type of treatment in which a patient’s T-cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T-cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T-cells are grown in the laboratory and given to the patient by infusion. Vaccines such as CMV-MVA triplex are made from gene-modified viruses and may help the body build an effective immune response to kill cancer cells. Giving CMV-specific CD19-CAR T-cells plus the CMV-MVA triplex vaccine following a stem cell transplant may help prevent the cancer from coming back. |
ALEX HERRERA; | 2023-08-01 |
| 188 | Study IL- 35 Level and Fibronectin Type Ⅲ Domain Containing Protein 5 \ Irsin (FNDC5 Rs3480) Gene Variations in Chronic Hepatitis B PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Find a possible association between Fibronectin type Ⅲ domain containing protein 5 \ Irsin (FNDC5 rs3480) gene single nucleotide polymorphism with chronic hepatitis B and the distribution of its alleles, in relation to many clinical parameters of the chronic hepatitis B group. – Asses the correlation between IL-35 serum level and the risk of chronic hepatitis B. – Asses the correlation between SOD serum level and the risk of chronic hepatitis B. |
SHIMAA BADWAY HEMDAN; | 2023-07-20 |
| 189 | Social Determinants of Health in Hepatobiliary Cancer Patients PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates barriers to receiving care and risks associated with developing cancer among patients diagnosed with hepatobiliary cancer. |
NGUYEN H. TRAN; | 2023-07-17 |
| 190 | A Single-center, Randomized, Active-controlled, Parallel-group, Double-blind, Phase I Clinical Trial to Evaluate Safety and Immunogenicity of Hexavalent Vaccine (APV006) in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, randomized, active-controlled, parallel-design, double-blind, phase I study to evaluate the safety and immunogenicity of a single dose of APV006 in healthy adults. |
NAM JOONG KIM; | 2023-07-17 |
| 191 | A Phase Ib Multi-stage Plasmodium Falciparum Malaria Vaccine Study to Assess The Safety and Immunogenicity of The Blood-stage Vaccine Candidate RH5.2 Virus-like Particle (VLP) in Matrix-M and The Pre-erythrocytic Stage Vaccine Candidate R21 in Matrix-M, Both Alone and in Combination, in Adults and Infants in The Gambia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase Ib multi-stage Plasmodium falciparum malaria vaccine study to assess the safety and immunogenicity of the blood-stage vaccine candidate RH5.2 virus-like particle (VLP) in Matrix-MTM and the pre-erythrocytic stage vaccine candidate R21 in Matrix-MTM, both alone and in combination, in adults and infants in the Gambia |
UMBERTO D’ALESSANDRO; | 2023-07-10 |
| 192 | Effect of Sugarcane Juice on Liver Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the potential benefits of sugarcane juice on liver health in patients who are suffering from liver-related conditions. We hypothesize that regular consumption of sugarcane juice may improve liver function and alleviate symptoms in patients with liver disease. Patients participating in this study will consume a specified amount of sugarcane juice daily for 90 days, and their liver health will be monitored to assess any improvements. This study could help identify a natural, accessible treatment option to support liver health in patients with liver disease, potentially improving their quality of life. |
NAEEM MUJAHID; | 2023-07-10 |
| 193 | MEXWILS – Performance and Safety of MEX-CD1 Low-volume Continuous Veno-venous Haemodialysis Medical Device for Copper-extraction in Patients With Wilson’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test the MEX-CD1 hemodialysis medical device in patients suffering from Wilson’s Disease. The main questions it aims to answer are: – Does the device work as expected by removing the excess of free copper from the blood? – Is the device safe when used according to the instructions for use? Depending on the severity of their symptoms, patients will receive either 5 or 10 treatments on consecutive days with the MEX-CD1 hemodialysis medical device. |
EDOUARDO COUCHONNAL-BEDOYA; | 2023-07-01 |
| 194 | Establishment of Rapid Diagnostic Procedure of HCV Single-sample Detection Platform in China PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study aims to establish a one-sample testing platform and assess the prevalence of hepatitis C in individuals taking routine physical examination or outpatient visit in mainland China. |
WEN-HONG ZHANG; | 2023-06-30 |
| 195 | Effect Of Scaling and Root Planning on Alkaline Phosphatase in Saliva and Gingival Crevicular Fluid in Periodontitis Patients Compared With Healthy Subjects Before and After Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this [interventional clinical trial] is to test effect of scaling and root plaining on Alkaline phosphatase in Saliva and Gingival crevicular fluid in periodontitis patients compared with healthy subjects The population from periodontitis patients compared with healthy individuals It aims to answer are: • 1_Alkaline phosphatase level in saliva and GCF. 2_Scaling and root plaining effect on Alkaline Phosphatase level. 0 participants will be asked to maintain their oral hygiene instructions. Researchers will compare [periodontitispatientsto healthyindividuals] to see if [AlkalinePhosphatase level]. |
AZZAHRAA ABDEL FATTAH ABDELRAHIM; | 2023-06-15 |
| 196 | Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of HT-102Injection in Healthy Subjects and Hepatitis B E Antigen-Negative Patients with Chronic Hepatitis B Virus Infection: A Randomized, Double-blind, Placebo-controlled, Single and Multiple Subcutaneous Injections, and Dose Escalation Phase 1 Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of HT-102 (BM012) Injection in Healthy Subjects and Hepatitis B e Antigen-Negative Patients with Chronic Hepatitis B Virus Infection: A Randomized, Double-blind, Placebo-controlled, Single and Multiple Subcutaneous Injections, and Dose Escalation Phase 1 Clinical Study |
SUZHOU HEPATHERA BIOTECH | 2023-06-12 |
| 197 | Relapse Prevention in Stimulant Use Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the relationship between bupropion, stimulant use and relapse, ADHD (Attention Deficit Hyperactivity Disorder), and measures of mood, drug craving, … |
EDYTHE LONDON; | 2023-06-11 |
| 198 | A Phase 2, Multi-country, Randomized, Double-blind, Placebo-controlled Trial to Evaluate Safety and Immunogenicity When HIL-214 Is Concomitantly Administered With Routine Pediatric Vaccines in Healthy Infants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2, multi-country, randomized, double-blind, placebo-controlled trial to evaluate the immune response to routine pediatric vaccinations when co-administered with HIL-214 or placebo in healthy infants. This trial will also evaluate the safety profile of a 2-dose regimen of HIL-214 co-administered with routine pediatric vaccines. |
HILLEVAX | 2023-06-10 |
| 199 | Efficacy and Safety of Hepatitis B Virus Vaccine(HBV) in Treatment of Cutaneous Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of the work: 1. Evaluate efficacy and safety of Intralesional HBV vaccine injection as a treatment of plane and genital warts. 2. Evaluate efficacy and safety of Intramuscular HBV vaccine injection as a treatment of plane and genital warts. 3. Compare the efficacy of different doses(0.3ml vs 0.5ml )of intralesional HBV vaccine injection for treatment of plane and genital warts. 4. Compare the efficacy of intralesional HBV vaccine injection vs Intramuscular HBV vaccine injection in treatment of plane and genital warts. |
MARIA AWNY ARMIA; | 2023-06-10 |
| 200 | Specific Use-results Study of IMJUDO Intravenous Infusion 25mg / IMFINZI Intravenous Infusion 120mg,500mg All Patient Investigation in Patients With Unresectable Advanced or Recurrent Non-small Cell Lung Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To collect information of safety in patients with unresectable advanced or recurrent non-small cell lung cancer who receive combination therapy of IMJUDO, IMFINZI and other platinum-based anti-cancer agents under actual use in the postmarketing setting. |
ASTRAZENECA | 2023-06-02 |
| 201 | Delivering An Innovative Multi-disease Screening Tool to High-risk Migrant Populations PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Migrants’ overall health status may be improved by increasing the detection of certain infectious diseases and other conditions for which effective care is available. This can be achieved through a systematic screening of these conditions using innovative and digital solutions implemented in routine health care. This study aims to evaluate the implementation of a screening programme for migrants at primary care level in two different settings of Spain (Catalonia and Andalusia) using an innovative digital and user-friendly software tool (ISMiHealth). In Catalonia, … |
ANA REQUENA MÉNDEZ; | 2023-06-01 |
| 202 | A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (Sustained HBsAg Loss) (B) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis B virus (HBV) infection is a major public health threat in China. At present, a functional cure, also known as clinical cure or sustained Hepatitis B surface antigen (HBsAg) loss, is recommended as the ideal endpoint of HBV treatment. However, HBsAg loss can be achieved in less than 10% of chronic hepatitis B (CHB) patients treated with current available antiviral drug interferon (IFNα) or nucleos(t)ide analogues (NAs) monotherapy. With the support of the national major special funding for infectious diseases from 11th Five-Year Plan to 13th Five-Year Plan, … |
HONG REN; | 2023-06-01 |
| 203 | Prospective Multicenter Study: PredIcting SterOid DepeNdEnt LivEr Injury (PIONEER) With Polyreactive Immunoglobulin G PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators identified polyreactive immunoglobulin G (pIgG) in adults (published in Hepatology: https://doi.org/10.1002/hep.32134) and children (in preparation). Quantification of these pIgG using a home-made ELISA facilitates the diagnosis of autoimmune hepatitis (AIH) as compared to non-AIH liver diseases and healthy controls. Positivity for pIgG was independent from ANA/SMA positivity and equally diagnostic for AIH even when conventional autoantibodies (ANA/SMA/SLA/LKM) were negative. Additionally, the frequency of pIgG was lower than conventional autoantibodies (ANA, … |
BASTIAN ENGEL; | 2023-06-01 |
| 204 | Color Doppler Ultrasound and Transient Elestoghraphy As Predictors for Presence of Gastroesophageal Varices and Variceal Bleeding in Patients With Liver Cirrhosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate the ability of Doppler ultrasonography of the portal vein and liver stiffness measurement using Transient Elestoghraphy in predicting prescence of gastroesophageal variceal and variceal bleeding in patients with liver cirrhosis |
REHAM MAMDOUH KEMALY; | 2023-06-01 |
| 205 | Double-blinded, Placebo-controlled, Munticenter, Phase IIa Clinical Trial of Hepalatide in Patients With Chronic Hepatitis D PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A phase 2a clinical Study of Hepalatide for Injection in Subjects with Chronic Hepatitis D |
JUNQI NIU; | 2023-06-01 |
| 206 | The Effect of Foot Massage Applied Before and After Cholecystectomy Surgery on Anxiety, Pain and Comfort Level PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim and objectives:The aim of this study is to examine the effect of foot massage on reducing pain and anxiety and increasing the comfort level in patients undergoing laparoscopic cholecystectomy. Design:The study is a randomized controlled experimental study with a pretest posttest control group. Methods:This study will be carried out in Niğde Ömer Halisdemir University Training and Research Hospital General Surgery Clinic. Participants were divided into massage group and control group. Vital signs of the massage group will be taken 2 hours before the operation and Surgical Anxiety Scale will be applied to adult patients (n=40). At this stage, … |
NESIBE SULTAN ÇINAROĞLU; | 2023-06-01 |
| 207 | Clinical Study of Allogeneic Adipovarian Active Protein in The Treatment of Severe Idiopathic Pulmonary Fibrosis Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trail is to study the efficacy and safety of allogeneic adipocyclical active protein in the treatment of severe idiopathic pulmonary fibrosis. The main questions it aims to answer are: 1. Efficacy of allogeneic adipromic active protein in the treatment of severe idiopathic pulmonary fibrosis 2. Safety of allogeneic adipovularic active protein in the treatment of severe idiopathic pulmonary fibrosis. A total of 7 participants will be enrolled. Participants will be asked that they will receive 2ml of each nebulized inhalation Cell Free Fat Extract (CEFFE), inhaled every 3 days, … |
SHANGHAI NINTH PEOPLE’S HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY | 2023-06-01 |
| 208 | A Phase 2, Open-label Study to Assess The Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects with Chronic Hepatitis C Virus (HCV) Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label trial to evaluate safety and efficacy of treatment with BEM + RZR in subjects with chronic HCV infection. |
ATEA PHARMACEUTICALS | 2023-05-30 |
| 209 | Effects of Hepatic Fibrosis on Quantifying Hepatic Steatosis Using The Ultrasound Attenuation Imaging in Patients With Chronic Hepatitis B: A Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigator aimed to prospectively study the effect of the hepatic fibrosis on quantifying hepatic steatosis using ultrasound attenuation imaging (ATI value) in patients with chronic hepatitis B. |
SO YEON KIM; | 2023-05-20 |
| 210 | A Novel, Potent and Non-addictive Analgesic of Combinations for Knee Replacement Moderate to Severe Pain Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the safety, efficacy, and pharmacokinetics of oral SafeTynadol, Naldebain and Naldebain combine with SafeTynadol in the treatment of moderate to severe pain following knee replacement. |
CHENG-FONG MR CHEN; | 2023-05-18 |
| 211 | A Single-center, Single-arm, Open-label Phase IIA Clinical Trial to Investigate Efficacy and Safety of Ritlecitinib (PF-06651600) in Patients With Cutaneous T Cell Lymphomas Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to evaluate the effectiveness and safety of Ritlecitinib in skin and blood in persons with Cutaneous T-Cell Lymphoma (CTCL). CTCL is a rare type of cancer that starts in the white blood cells and eventually can result in rashes or tumors in the skin. This study includes a 24 week Treatment Period and a 24 week Follow-up Period. This study will involve physical examinations, visual assessments, laboratory tests, PET-CT scans, electrocardiograms, photographs of your skin, skin biopsies, and hearing tests. |
PATRICK BRUNNER; | 2023-05-17 |
| 212 | Investigation of The Passage of Antiviral Antibodies From Mother to Child PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Infections remain a major cause of neonatal morbidity and mortality worldwide. At birth, multiple microorganisms, to which they are particularly vulnerable given the immaturity and naïve nature of their immune system, … |
CHRISTELLE VAULOUP FELLOUS; | 2023-05-15 |
| 213 | Observational Study of The Interaction Between Hepatitis C Virus Infection and Pregnancy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about he effects of hepatitis C virus on pregnancy. The main question[s] it aims to answer are: Effect of hepatitis C virus on liver function in pregnant women Mother-to-child transmission rate in pregnant women with hepatitis C |
YAO XIE; | 2023-05-09 |
| 214 | Safety, Tolerability, and Impact of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants With Both Chronic Hepatitis B and HIV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to assess safety and tolerability of oral toll-like receptor (TLR) 8 agonist Selgantolimod (SLGN) administered for 24 weeks in participants with both CHB and HIV who have been receiving suppressive antiviral therapy for both viruses for ≥5 years and have qHBsAg level \>1000 (3 log10) IU/mL at screening. The study will also evaluate if TLR8 stimulation with SLGN will reduce hepatitis B surface antigen (HBsAg) titers in the blood. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2023-05-05 |
| 215 | A Feasibility Study of Controlled Human Infection With Intradermal Bacillus Calmette-Guérin Injection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is a disease that usually causes an infection in the lungs. The only vaccine to prevent TB is called BCG (Bacillus Calmette-Guérin). BCG contains a live germ similar to Mycobacterium tuberculosis, the germ that causes TB. BCG does not work very well, … |
BEN MORTON; | 2023-05-02 |
| 216 | Evaluation of Tasso+ Capillary Blood Self-Collection for Clinical Diagnostic Assessment of Various Biomarkers PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the effectiveness and reliability of the Tasso+ capillary blood self-collection device in the clinical diagnostic assessment of various biomarkers. The study will collect blood specimens using both the Tasso+ self-collection device and traditional venipuncture. The biomarker analysis results from both specimen types will be compared for correlation. |
SRI BHARAT MADIREDDY; | 2023-05-01 |
| 217 | A Phase II, Randomized, Observer-blinded, Placebo Controlled Trial to Evaluate The Safety and Immunogenicity of Hecolin® in Healthy Pregnant Women Between Gestational Age 14-34 Weeks and Non-Pregnant Women of 16-45 Years Old PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II randomized, observer-blinded, placebo-controlled study with 3 arms enrolling a total of 2,358 participants. The arms are composed of Arm 1, pregnant participants receiving Hecolin® (N=1,104) with immunogenicity subset (n=150), Arm 2, pregnant participants receiving placebo (N=1,104) with immunogenicity subset (n=150), and Arm 3, non-pregnant participants receiving Hecolin® (N=150) of which all participants in this arm will be included in the immunogenicity subset. |
INTERNATIONAL VACCINE INSTITUTE | 2023-05-01 |
| 218 | A Multi-country, Multi-center, Open-labelled, Randomized, Controlled, Extended Phase Ⅲ Clinical Trial to Evaluate The Immunogenicity and Tolerability of Sabin Strain Inactivated Poliovirus Vaccine Administered With or Without Routine Infant Vaccines PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to study the immunogenicity and safety of sIPV co-administered with other routine infant vaccines. According to the national immunization schedule of Bangladesh and Pakistan, sIPV was administered concomitantly with PCV10, DTP-HeB-Hib and other vaccines at 6, 10 and 14 weeks old. Thus, this study set up the concomitant vaccination schedule according to the real practice in study area. The primary hypothesis of this study is the seroconversion rate of polio vaccination when administered concomitantly with routine vaccines, is non-inferior to that when administered alone; the secondary hypothesis of this study is the seropositivity rate of diphtheria, … |
WASIF A KHAN; | 2023-05-01 |
| 219 | Effectiveness and Safety of Bulevirtide (BLV) Therapy in Patients With Chronic Hepatitis Delta (CHD) in Italy: A Multicenter Prospective Real Life Data Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicenter pharmacological observational prospective, no-profit, study. This study was designed to get a real-life snapshot across several Italian Hepatology centers. All HDV patients are followed up according to EASL 2017 guidelines. This allows uniformity on the indication for antiviral treatment and management of that antiviral therapy. No off-label medications are used. All data are retrievable from the patient’s medical record. In addition, clinical and biochemical data from patients at month 0, 1, 2, 4, 6 and 12 of treatment, and otherwise within the study period, … |
FONDAZIONE IRCCS CA’ GRANDA OSPEDALE MAGGIORE POLICLINICO | 2023-05-01 |
| 220 | Targeted Focus Groups Discussions (FGDs) and Cross-sectional Questionnaire to Address Questions Regarding Telemedicine Concept and Knowledge, and Social Media Usage Among People Who Inject Drugs (PWID) in Greece PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current study seeks to address questions regarding internet and social media usage as well as telemedicine concept and knowledge, by conducting targeted focus group discussions (FGDs) and administering cross-sectional questionnaires among PWID in Greece. Further parameters, such as perceptions for high-quality healthcare access, confidentiality, privacy, and security, will also be explored. |
ANDREW TALAL; | 2023-05-01 |
| 221 | Hellenic Multicenter Real-life Clinical Study for Bulevirtide Therapy in Chronic Hepatitis D: HERACLIS-BLV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the efficacy and safety of bulevirtide (BLV) in chronic hepatitis D patients treated in Greek liver centers. |
GEORGIOS PAPATHEODORIDIS; | 2023-05-01 |
| 222 | Development of Point-of-care and Wearable Sensors for Hepatitis C Diagnostics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C diagnostic devices have been developed at the University of Hull to detect and quantify the Hepatitis C virus in patients’ plasma and serum samples. This study aims to test the new point-of-care devices that are designed to be low cost and user-friendly. Excess, stored, HCV patients’ plasma, serum and blood samples will be supplied by the Virology laboratory (Hull University Teaching Hospital’s Trust; HUTH). These samples were taken and analysed as part of patients’ clinical monitoring, and are stored prior to disposal in the Virology laboratory. The proposed study will use the samples in a fully anonymised manner. |
MOHAMMAD IBRAHIM; | 2023-05-01 |
| 223 | Multicenter, Randomized, Double-blind, Placebo / Positive Control Evaluation of The First Safety, Pharmacokinetic and Pharmacodynamic Phase I Clinical Trial of Rabies Monomab CBB 1 in Healthy People PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: rabies mab CBB 1 is mainly used for passive immunization of patients bitten or scratched by rabies or other animals carrying rabies virus, this study mainly studies the safety, tolerability, pharmacokinetics, neutralizing antibody activity and immunogenic characteristics of rabies mAb CBB 1 in healthy adults |
CHANGCHUN BCHT BIOTECHNOLOGY | 2023-04-30 |
| 224 | Phase I Clinical Study to Evaluate The Safety, Tolerance and Pharmacokinetic Characteristics of Single Administration of HRS-5635 Injection in Chinese Healthy Subjects and The Safety, Tolerance, Pharmacokinetics and Antiviral Effect of Multiple Administration in Patients With Chronic Hepatitis B PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-5635 in healthy adults and chronic hepatitis B. To explore the reasonable dosage of HRS-5635. |
FUJIAN SHENGDI PHARMACEUTICAL | 2023-04-30 |
| 225 | Prophylaxis With Direct-acting Antivirals for Kidney Transplantation From Hepatitis C Virus-Infected Donors to Uninfected Recipients: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to find out the best time to start medication for Hepatitis C Virus (HCV) in HCV-negative recipients of HCV-positive (HCV D+/R-) kidney transplants. Participants will be randomized into one of two groups: Arm 1 – Prophylaxis: This group will start the HCV medication before transplant and will take a shorter course of HCV medication for 2 weeks. Arm 2 – Transmit and Treat: This group will start the HCV medication after transplant and will take the full course (12 weeks) of HCV medication. |
CHRISTINE DURAND; | 2023-04-19 |
| 226 | Early Detection of Advanced Liver Disease Via Artificial Intelligence-Enabled Electrocardiogram (Advance): A Pragmatic, Cluster-Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall objectives of this study are to determine the effectiveness of ACE 2.0 model in early detection of advanced liver fibrosis, and to determine the acceptance and barriers for use of an AI-enabled algorithm for prediction of liver disease in primary care. |
DOUGLAS (DOUG) A. SIMONETTO; | 2023-04-18 |
| 227 | Clinical Efficacy and Safety of Tenofovir Disoproxil Fumarate and Entcavir in Treatment of Chronic Hepatitis B Patients in Upper Egypt PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic hepatitis B (CHB) is one of the major causes of chronic liver diseases worldwide. Around 296 million people were living with chronic hepatitis B infection, with 1.5 million new infections each year and more than 820 thousand people die because of hepatitis B virus (HBV) related complications |
REHAB ABDELRAOF MOHAMED; | 2023-04-15 |
| 228 | Assessment Of Gene Expression Of Suppressor Of Cytokine 3, Interferons Alpha And Beta In Cutaneous Warts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Warts are common epidermal growths caused by various strains of human papilloma virus (HPV). Viral warts are common with a prevalence rate of 7-12%. Human papilloma virus is small non enveloped viruses that contain a double-stranded DNA genome. There are more than 200 HPV genotypes are reported, however, the high-risk types, including HPV genotype-16 (HPV16), 18, 31, and 45, are the causes of 80% of cervical cancers. |
REHAM HELAL ABOELHAMD; | 2023-04-15 |
| 229 | Immunogenicity of COVID-19 Vaccines Against Coronavirus Disease (COVID-19) Among Tuberculosis (TB) Patients in Thailand-Myanmar Border PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a non-randomized observation and comparison of immune response between bacteriologically confirmed TB patients under treatment cohort who received COVID-19 vaccine (n=54) vs healthy individuals (n=54). Each participant will receive single or double doses of one of COVID-19 vaccines (Pfizer-BioNTech COVID-19 vaccine, … |
FRANÇOIS NOSTEN; | 2023-04-15 |
| 230 | Sociodemographic and Clinical Characteristics of Patients Admitted to The Addiction Management Unit of Assiut University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Substance use disorder (SUD) is a dynamic process that changes constantly over time with new trends of drug dependence emerge every now and then, thus timely information about trends in psychoactive substance use could yield tailored interventions and reduce potential harms. Identifying personal, social, and demographic characteristics of patients with this disorder at the local, regional, and national levels helps physicians, health authorities, and policy-makers detect early emerging trends and enable them better plan and implement prevention, treatment, and rehabilitation programs. This study aims to identify sociodemographic, personal characteristics, … |
MENA FAHY RIZQ FARAG; | 2023-04-13 |
| 231 | Epidemiology of Occult Hepatitis C Virus Infection in Patients Born Before 1969 in The Hospital Setting: A Spontaneous Opportunistic Screening Initiative PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this monocentric prospective observational study is to evaluate the prevalence of unknown hepatitis C virus chronic infection in general population born before january 1st 1968 in Italy. The main questions it aims to answer are: what is the prevalence of hepatits C virus infection in general population born before January 1st, … |
PONZIANI FRANCESCA ROMANA; | 2023-04-10 |
| 232 | Incidence, Severity, and Determinants of Upper Back, Lower Back, and Pelvic Girdle Pain in The Late Postpartum Period PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Upper back, lower back and pelvic girdle pain significantly affect women’s lives, especially in the postpartum period. This study aimed to characterize the frequency and severity of upper back, lower back and pelvic girdle pain in the 0 to 2 months postpartum period. The study will be conducted as a cross-sectional and correlational study. Data will be collected using the Information Form and Brief Pain Inventory designed by the researchers. Data will be collected face to face with the participants at the end of the first week, … |
SENA DILEK AKSOY; | 2023-04-03 |
| 233 | A Phase 1a/1b Study to Evaluate The Safety and Tolerability of Repeated Doses of Nonreplicating Arenavirus Vector Therapeutic Vaccines GS-2829 and GS-6779 in Healthy Participants and Participants With Chronic Hepatitis B (CHB) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to learn more about GS-2829 and GS-6779 in healthy participants and participants with CHB. |
GILEAD SCIENCES | 2023-04-03 |
| 234 | Expanding Donor Liver Utilization: A Case Series Study of Triple Recipient Strategy Using Split, Domino, and Auxiliary Techniques Related Papers Related Patents Related Grants Related Experts View Highlight: We report a case of the simultaneous use of split liver transplantation (SLT), domino liver transplantation (DLT) and auxiliary liver transplantation (ALT) to achieve one donor for three recipients. |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2023-04-02 |
| 235 | Prevalence of Sub-clinical Hypothyroidism Among Pregnant Women During First Trimester: Cross Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: this study may help the physicians to evaluate the practice of universal screening of sub-clinical hypothyroidism and thyroid-stimulating hormone level. Detection of sub-clinical hypothyroidism early in pregnancy through thyroid-stimulating hormone sampling in the first trimester will allow achieving proper management and better maternal and neonatal outcome of these patients. |
AMIRA MOSTAFA MAHMOUD; | 2023-04-01 |
| 236 | The Prevalence of Oral HPV Infection and Oral Lesions in People Living With HIV in A HIV Primary Care Clinic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will evaluate 300 people living with HIV that attend the Vivent Clinic for HIV care. We will characterize our population and include age, race/ethnicity, sex at birth, tobacco use, alcohol use, other comorbidities, HPV vaccination status, other HPV disease, and lab values such as CD4 count and HIV viral load. We will compare results between participants who are HPV positive and negative. We will also evaluate the relationship between HPV oral infections and lesions and the variables above to better understand possible predictors of HPV infections and lesions. |
CINDY FIRNHABER; | 2023-04-01 |
| 237 | Awareness of Osteoporosis in Patients With Hepatitis C Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoporosis is a condition that describes compromised skeletal microarchitecture in general, with clinical signs of decreased bone mineral density. Patients with hepatitis c virus infection are at increased risk for developing osteoporosis. Identifying whether patients with hepatitis c virus infection have information and awareness about this disease is crucial. This study is aimed to investigate awareness and knowledge of osteoporosis in patients with hepatitis c virus infection. |
MUSTAFA HÜSEYIN TEMEL; | 2023-04-01 |
| 238 | Awareness of Osteoporosis in Patients With Hepatitis B Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoporosis is a condition that describes compromised skeletal microarchitecture in general, with clinical signs of decreased bone mineral density. Patients with hepatitis b virus infection are at increased risk for developing osteoporosis. Identifying whether patients with hepatitis b virus infection have information and awareness about this disease is crucial. This study is aimed to investigate awareness and knowledge of osteoporosis in patients with hepatitis b virus infection. |
MUSTAFA HÜSEYIN TEMEL; | 2023-04-01 |
| 239 | Efficacy and Safety of Bulevirtide (BLV) Therapy in HDV Chronic Hepatitis (CHD) Patients in Italy: A National Real Life Data Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Spontaneous, pharmacological observational, no-profit, retrospective, multi-center. This study was designed to get a real-life snapshot across several Italian Hepatology centers. All HDV patients are followed up according to EASL 2017 guidelines. This allows uniformity on the indication for antiviral treatment and management of that antiviral therapy. No off-label medications are used. All data are retrievable from the patient’s medical record. In addition, clinical and biochemical data from patients at month 0, 1, 2, 4, 6 and 12 of treatment, and otherwise within the study period, … |
FONDAZIONE IRCCS CA’ GRANDA OSPEDALE MAGGIORE POLICLINICO | 2023-04-01 |
| 240 | Effect on Non-Alcoholic Fatty Liver Disease With Advanced Fibrosis in Patients With Type 2 Diabetes Mellitus on Treatment With Gastric Inhibitory Polypeptide / Glucagon Like Peptide-1 Analogue (Tirzpatide) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity and type 2 Diabetes Mellitus prevalence has doubled in the last 30 years and nearly one fifth of UAE population has Type 2 Diabetes while more than quarter has obesity. Non-alcoholic fatty liver disease is present in more than 30% of patients with type 2 diabetes and in > 50% patient with obesity 20% of patients with Non-alcoholic fatty liver disease progress to develop non-alcoholic steatohepatitis which can lead to liver failure and hepatocellular carcinoma. This study aims to use GLP-1 analogue to see effects on liver fat deposition after six months of treatment There is no current randomised study on treatment of non-alcoholic steatohepatitis in United Arab Emirates population; so once completed this will the first study. This study will pave the way for developing a treatment pathway for patients with non-alcoholic fatty liver disease. |
ADNAN AGHA; | 2023-04-01 |
| 241 | Efficacy of The Hepatitis B Vaccination Post Hypothermia for Hypoxic Ischemic Encephalopathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the research is to determine if the Hepatitis B vaccine after birth provides enough protection after cooling for Hypoxic Ischemic Encephalopathy (HIE). To do this, Hepatitis B titers (blood sample) would be taken before, during, and after administering of the Hepatitis B vaccine series to measure efficacy of the vaccine. |
FLORIAN CAPOBIANCO; | 2023-04-01 |
| 242 | Treating Donors With Intravenous Immunoglobulin to Reduce Donor-Derived Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the benefit of IVIG in donor-derived infections and the potential immunomodulatory effect on transplanted organs. The main questions it aims to answer are: 1. How effective IVIG is in preventing donor-derived infections 2. Does IVIG has potential immunomodulatory effect on transplanted organs |
SHANGHAI CHANGZHENG HOSPITAL | 2023-04-01 |
| 243 | Comparison Between Thromboelastography and Conventional Coagulation Tests in Pediatrics With Chronic Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: – Compare between thromboelastography (TEG) and conventional coagulation tests (CCT) in children with chronic liver disease who admitted to Assiut University Children Hospital. – Detect the advantages of TEG in predicting the risk of bleeding, assessing haemostasis and guiding blood product transfusion for each coagulation defect . |
MENNAT-ALLAH HESHAM ABDELRAHEEM; | 2023-04-01 |
| 244 | A Phase 3, Open Label, Single-Arm Clinical Trial to Evaluate The Efficacy and Safety of MK-8228 (Letermovir) for The Prevention of Clinically Significant Cytomegalovirus (CMV) Infection in Chinese Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and safety of a once-a-day oral or intravenous (IV) dose of Letermovir (MK-8228) in Chinese adult hematopoietic stem cell transplant (HSCT) recipients for the prevention of clinically significant cytomegalovirus (CMV) infection. |
MERCK SHARP & DOHME | 2023-03-24 |
| 245 | A Randomized, Double-blind, Active Comparator Clinical Trial to Evaluate Safety and Immunogenicity of Thiomersal-free Recombinant Hepatitis E Vaccine (Escherichia Coli) in People Ages 16 Years and Above PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and non-inferior immunogenicity of thiomersal-free Recombinant Hepatitis E Vaccine (Escherichia Coli) compared with licensed Recombinant Hepatitis E Vaccine (Escherichia Coli) when administered in participants ages 16 years and above. |
DONGJUAN ZHANG; | 2023-03-22 |
| 246 | A Multicenter, Double-blind, Active-controlled, Randomized, Parallel Clinical Study to Evaluate The Efficacy and Safety of DA-2803 in Chronic Hepatitis B Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-center, double-blind, active-controlled, randomized, parallel clinical study to evaluate the efficacy and safety of DA-2803 in chronic hepatitis B subjects |
DONG A ST | 2023-03-20 |
| 247 | Prospective Cohort Study to Determine The Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The COVID-19 global pandemic killed more than 6 million people worldwide. Several vaccines have been developed against the virus that causes this disease. These vaccines are effective at preventing severe symptoms and death from COVID-19. Some people with chronic liver disease, especially those with an advanced condition called cirrhosis, … |
MARC G GHANY; | 2023-03-15 |
| 248 | Acceptance and Feasibility of Hepatitis C Screening Strategies in Social Insertion Centers With Alternative Sentences to Prison and Open System PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver disease worldwide. It is a progressive disease that without treatment leads to the development of cirrhosis in approximately 10-20% of patients. With this study the investigators intend to evaluate the efficacy defined as the rate of HCV diagnostic tests performed within a decentralized diagnostic strategy by means of home self-testing compared to the one performed in situ in the population served in Social Insertion Centers (CIS) with alternative prison sentences, in order to study the prevalence and characteristics associated with HCV infection in this population, … |
MANUEL HERNANDEZ-GUERRA; | 2023-03-10 |
| 249 | Simplifying Hepatitis B Care in Pregnancy By Combining Birth-dose Vaccine and Tenofovir: The COMBAT HBV Feasibility Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double-blind, randomized placebo-controlled trial (RCT) of a prophylaxis-for-all approach to prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in the Democratic Republic of Congo (DRC). HBV-infected pregnant women will be randomized to either receive tenofovir or placebo beginning at 28-32 weeks’ gestation and continuing through 12 weeks’ postpartum. Women will be followed every 4-6 weeks throughout the prenatal and postpartum period to evaluate for side effects related to the medication. Infants will receive a birth-dose of HBV vaccine, ideally within 24 hours. Participants will be followed longitudinally through 6 months’ postpartum. |
PEYTON THOMPSON; | 2023-03-01 |
| 250 | A Prospective, Observational, Parallel Control, Multicenter Study to Evaluate The Efficacy and Safety of Tenofovir Amibufenamide in The Treatment of Chronic Hepatitis B Patients With Low-level Viraemia (Power Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to explore the efficacy and safety of Tenofovir Amibufenamide (TMF) in Entecavir (ETV) treated chronic hepatitis B patients with low-level viraemia. The main question it aims to answer is: – The efficacy and safety of TMF in chronic hepatitis B patients with low-level viraemia. – … |
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY | 2023-03-01 |
| 251 | Prospective Analysis of Pharmacokinetic Infliximab Data in Pediatric CD Patients (ProRAPID) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Crohn’s disease (CD) is a chronic, debilitating inflammatory bowel disease (IBD) which is diagnosed during childhood in up to one in ten patients. The use of anti-tumor necrosis factor (TNF)-α agents has significantly ameliorated CD management. Infliximab (IFX) is the first anti-TNF-α agent registered for pediatric CD. The current dosing recommendation of IFX is extrapolated from adult studies, and it is a weight-based dose (5 mg/kg) delivered during induction (infusion at weeks 0, 2, and 6) and maintenance (every 8 weeks). However, pediatric patients have a 25-40% lower drug exposure compared to adults, … |
LISSY DE RIDDER; | 2023-03-01 |
| 252 | Proteinuria As An Early Prognostic Factor for Detecting Possible Renal Affection After Liver Transplantation, A Single Egyptian Center Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Proteinuria has been suggested to be a predictive factor and an important tool for differentiating the etiology of renal dysfunction in various clinical scenarios .The good predictive performance of preoperative proteinuria utilized for the development of renal failure after operation has been reported . In the literature, prognostic significance of several scoring systems for end-stage liver disease has been validated . The Sequential Organ Failure Assessment (SOFA) system was found to be superior to ChildPugh points (CP points) and Model for End-Stage Liver Disease (MELD) score, … |
MARWA M.ABOKRESHA; | 2023-03-01 |
| 253 | A Randomized, Double-blind, Placebo-controlled Study to Evaluate The Safety, Tolerability, and Pharmacokinetics of AHB-137 with Single Ascending Doses and Multiple Doses in Healthy Volunteers and Initial Efficacy in Chronic Hepatitis B Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of AHB-137 subcutaneous injection in healthy volunteers and in chronic hepatitis B (CHB) patients after single and multiple doses. In addition, the study will evaluate the initial antiviral efficacy of AHB-137 in CHB patients following a multiple dosing regimen. |
ED GANE; | 2023-02-28 |
| 254 | Use of Blood Biomarkers for The Early Diagnosis of Hepatocellular Carcinoma (HCC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this observational study is to evaluate the clinical utility of the combined assay of 3 biomarkers: α-FP, α-FP-L3 and DCP (simultaneously measured by µTASWakoTM i30 automated in vitro diagnostic system) in high-risk subjects to develop this neoplasm. In particular, it aims to: – Evaluate the clinical utility of the combined use of α-FP, α-FP-L3 and DCP in predicting the onset of HEPATOCARCINOMA (HCC); – Evaluate the performance of GALAD and GALADUS scores in the early diagnosis of HCC; – … |
ENDRIT SHAHINI; | 2023-02-24 |
| 255 | D-SOLVE Cohorts (Cohort A and B) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis D is by far the most severe form of chronic viral hepatitis, frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection Hepatitis D is caused by co-infection with hepatitis B virus (HBV) and hepatitis D virus (HDV). This multicenter cohort should enable a comprehensive and unbiased biomarker screening of well-defined HDV-infected patients, followed by mechanistic studies to determine the functional role of distinct molecules. Patient surveillance strategies and antiviral treatment approaches could be personalized which should reduce clinical and social disease burden, … |
MARKUS CORNBERG; | 2023-02-22 |
| 256 | A Phase I Study of MRNA Vaccine for Patients With HBV-positive Advanced Hepatocellular Carcinoma Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and safety of mRNA vaccine for HBV-positive Advanced Hepatocellular Carcinoma. |
XINGCHEN PENG; | 2023-02-15 |
| 257 | A Registry Study of Treatment With Bulevirtide in Participants With Chronic Hepatitis D Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main goal of this study is to collect post marketing data from patients with chronic hepatitis D virus (HDV) infection who are treated with bulevirtide to describe the long-term effects of bulevirtide treatment and evaluate the safety of participants treated with bulevirtide. |
GILEAD SCIENCES | 2023-02-07 |
| 258 | The Gut Virome As A Trigger for IBD: From Metagenomics to Pathogenesis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Alterations in the composition of the intestinal microbiota (dysbiosis) are well known involved in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD). While bacteria have always gotten the most attention in gastrointestinal disorders, the viral component of the human gut microbiome, called the gut virome, is underestimated. In addition to bacteriophages, the gut virome also harbors viruses that infect eukaryotic cells, capable of transferring their information directly to host cells, … |
SILVIO DANESE; | 2023-02-07 |
| 259 | A Randomized, Controlled, Partial-Blind, Crossover Study to Characterize The Nicotine Pharmacokinetics and Subjective Effects of Five Oral Nicotine Products Relative to Moist Smokeless Tobacco (MST) in Adult MST Users PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to obtain information on nicotine exposure following the use of five oral tobacco-derived nicotine (OTDN) products relative to subjects’ own brand moist smokeless tobacco (OBMST) product in adult moist smokeless tobacco (MST) users, as well as to characterize subjective effects under controlled use conditions. Male and female adult MST users between the ages of 22 to 65 years were recruited. The total duration of participation for each subject was approximately 34 days including screening and a 6-day in-clinic study confinement period. |
ALTRIA CLIENT SERVICES | 2023-02-06 |
| 260 | A Retrospective Study of Chronic Hepatitis C Patients Treated With SOF/VEL/VOX: Real Life Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective, non-interventional study. Investigators from infectious diseases and gastroenterology departments will participate this study. Patients data will be collected from hospital medical records. |
FEHMI TABAK; | 2023-02-01 |
| 261 | PrEP Rapid Access: An Open Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to determine the feasibility and acceptability of an intervention (Rapid PrEP Access) providing people who inject drugs (PWID) immediate access to PrEP prescriptions through same-day human immunodeficiency virus (HIV) self-testing, … |
SABRINA ASSOUMOU; | 2023-02-01 |
| 262 | Comparison of The Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this prospective, double blind randomized clinical trial is to compare the effectiveness of two interventions in improve frailty (measured by Liver Frailty Index) and quality of life (measured by Chronic Liver Disease Questionnaire – CLDQ) in listed patients with cirrhosis. The main questions it aims to answer are: – if the intervention group (physical and nutritional therapy) could improve LFI over control group (physical and nutritional counseling). – if the intervention group could improve secondary outcomes as CLDQ, hand grip and gait velocity. Participants will be evaluated in a registry of basal variables such as demographic factors, … |
DIEGO REYES; | 2023-02-01 |
| 263 | Study on The Treatment of COVID-19 Infection By UDCA in Patients With Autoimmune Liver Disease and Its Clinical Prognosis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a two-way (retrospective+prospective) cohort study of patients with primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) infected with COVID-19. Enrolled PBC and AIH patients in clinical diagnosis and treatment at Beijing Ditan Hospital affiliated with Capital Medical University from January 2021 to December 2023. After enrollment, collect the demography data of patients, the treatment information of PBC and AIH patients, the use of ursodeoxycholic acid (UDCA) and immunosuppressants, COVID-19 vaccination, COVID-19 infection and incidence, clinical symptoms, clinical biochemistry, liver imaging, lung imaging, COVID-19 nucleic acid, COVID-19 antibody, … |
YAO XIE; | 2023-01-30 |
| 264 | Integrating Addiction and Infectious Diseases Services Into Primary Care in Rural Settings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate an intervention strategy in introducing screen/evaluate/treat (SET) procedures for HIV/ hepatitis C/ and Opioid Use Disorder in Primary Care Clinics in West Virginia. The main questions it aims to answer are: * What are the barriers and facilitators to integrating evidence based practices for screening and treatment of HIV, hepatitis C, and Opioid Use Disorder into primary care clinics in West Virginia? * To assess the extent to which our SET processes are achieved through enhanced EHR tools, … |
FREDERICK L ALTICE; | 2023-01-24 |
| 265 | Prospective Clinical Performance Evaluation of The In-Vitro Diagnostics Medical Device MaGIA IBC for The CombIned ScreENing of HIV, Hepatitis B and Hepatitis C PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective, cross-sectional, adaptative study to evaluate the clinical performance of the In-Vitro Diagnostics Medical Device MagIA IBC (a Multiplex Point-of-Care Test for the detection of HIV, HBV and HCV) in detecting anti-HIV antibodies (HIV-Ab), anti-HCV antibodies (HCV-Ab), and HBs antigens (HBs-Ag) in serum, plasma, venous blood and capillary blood. If not prescribed for the patient care, blood drawings, … |
MAGIA DIAGNOSTICS | 2023-01-23 |
| 266 | Small Volume Blood Testing Validity and Acceptability for HIV-1 and Hepatitis B PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: During the Covid-19 pandemic era, patients indicated that they find a model of care incorporating remote consultations to be acceptable [1-3]. Remote accessibility to care can be enhanced by using new technology to allow small volume testing for routine blood samples. This study aims to prospectively validate the use of small volume blood sampling for routine HIV-1 and Hepatitis B Virus (HBV) viral load (VL), liver function tests (LFTs) and creatinine, … |
STUART FLANAGAN; | 2023-01-23 |
| 267 | Hepatitis C Screening: HCV Risk Score Alerts in CHORUS™ PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate whether alerts that identify patients without hepatitis C infection to healthcare providers and clinic staff can increase the uptake of screening for hepatitis C. A period of time without alerts will be compared to a period of time with alerts. |
DOUGLAS DIETERICH; | 2023-01-16 |
| 268 | The National Australian HCV Point-of-Care Testing Program: An Observational Cohort Study to Evaluate The Use of Finger-stick Point-of-care Hepatitis C Testing to Enhance Diagnosis and Treatment of HCV Infection – Minimal Dataset PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The National Australian HCV Point-of-Care Testing Program will establish an observational cohort to evaluate whether scale-up of finger-stick point-of-care HCV testing increases diagnosis and treatment for HCV infection. Participants will be recruited from settings providing services to people with a risk factor for the acquisition of HCV infection (including drug treatment clinics, needle and syringe programs, homelessness settings, mental health services, prisons, … |
KIRBY INSTITUTE | 2023-01-16 |
| 269 | Efficacy of TDF and Entekavir Prophylaxis at Hepatitis B Reactivation: Multi Center Retrospective Study PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a non-interventional retrospective multi-center study for the patients received Entekavir or TDF for Hepatitis B prophylaxis. |
FEHMI TABAK; | 2023-01-15 |
| 270 | Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in Zimbabwe PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective interventional study to evaluate a strategy of point-of-care testing for sexually transmitted infections including chlamydia, gonorrhoea, trichomoniasis, syphilis, and Hepatitis B with comprehensive case management including partner notification in antenatal settings in Harare province, Zimbabwe. |
KEVIN MARTIN; | 2023-01-12 |
| 271 | Hepatitis C Disease Management: Diagnosis to Treatment Alerts in CHORUS™ PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate whether sending alerts to healthcare providers and clinic staff to identify patients with untreated hepatitis C infection can increase the uptake of hepatitis C treatment. A period of time without alerts will be compared to a period of time with alerts. |
MICHAEL WOHLFEILER; | 2023-01-09 |
| 272 | The Effect of Skin-to-Skin Contact After Elective Cesarean Section on Pain and Stress Levels of The First Intramuscular Injection of The Newborn PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is carried out to examine the effect of skin-to-skin contact on the pain and stress level of the first intramuscular injection after elective cesarean section. The universe of the research will be women who have had elective cesarean section at Darıca Farabi Training and Research Hospital. The sample size of the study was calculated using the G*Power 3.1.9.2 program. The minimum number of individuals to be included in the sample of this study was calculated by taking G*Power 3.1.9.2, effect size: 1.42 α= 0.05, power: 0.95, … |
SENA DILEK; | 2023-01-06 |
| 273 | Compassionate Use Access to REP 2139-Mg for The Treatment of Chronic HBV Infection or Chronic HBV / HDV Co-infection Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this compassionate access program is to provide early access to REP 2139-Mg for patients with HBV mono-infection or HBV / HDV co-infection who either have advanced (decompensated) cirrhosis or who have failed to response to other other antiviral agents either approved or under development and who are in danger of progressing to decompensated cirrhosis. This compassionate access program will provide access to a once weekly regimen of subcutaneously (SC) administered REP 2139-Mg for a period of 48 weeks with the goal of achieving functional cure of HDV and or HBV, … |
REPLICOR | 2023-01-04 |
| 274 | A Randomized, Double-blind, Placebo-controlled and Multicenter Phase Ⅱ Clinical Trials To Evaluate The Safety, Efficacy and Pharmacokinetics of GST-HG141 Tablets in Treated Chronic Hepatitis B (CHB) Patients With Low Viremia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Randomized, Double-blind, Placebo-controlled and Multicenter Phase Ⅱ Clinical Trials To Evaluate the Safety, Efficacy and Pharmacokinetics of GST-HG141 Tablets in Treated Chronic Hepatitis B (CHB) Patients With Low Viremia. |
FUJIAN AKEYLINK BIOTECHNOLOGY | 2023-01-03 |
| 275 | The Value of Fibroscan® in Assessing The Liver Status and Presence of MASLD/MASH in Patients With Chronic Hepatitis B and Monitoring Changes By Antiviral Therapy: Faraday Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to evaluate the consistency between liver biopsy and Liver Stiffness Measurement (LSM) for fibrosis and controlled attenuation parameter (CAP) for steatosis in FibroScan® in patients with chronic hepatitis B. The secondary aim of the study was to demonstrate the efficacy of FibroScan® for following the CHB patients at 12th month of antiviral therapy. The study was prospectively planned in four different centers. Patients with HBsAg positivity for more than six months and HBV-DNA>2,000 IU/mL, underwent liver biopsy and FibroScan® together within two week. FibroScan® was performed twice, … |
YAŞAR BAYINDIR; | 2023-01-02 |
| 276 | Glecaprevir/Pibrentasvir for The Treatment of PTSD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An open-label pilot study to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with posttraumatic stress disorder (PTSD) symptom improvement when prescribed for the treatment of chronic hepatitis C viral infection (HCV). |
BRADLEY WATTS; | 2023-01-01 |
| 277 | Evaluation of The Safety and Efficacy of Combination of Cryoablation and Dendric Cell/Cytokine-induced Killers Cells Treatment for Advanced Liver Cancers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The treatment of liver cancer needs integrated medical strategies, including surgery, chemotherapy, target therapy, radiotherapy, and immunotherapy. According to the patient’s condition to develop a personalized and best treatment plan. Cryoablation can produce osmotic shock through repeated freeze-thaw to cause tumor cell necrosis, and release tumor antigens to activate anti-tumor immune responses. Immune cell therapy is an emerging field across cancer types in current cancer treatment. This study desired to combine cryotherapy and cellular immunotherapy to achieve the effect of tumor control. In recent years, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2023-01-01 |
| 278 | The Dynamic Change of Fecal Calprotectin From Day 1 to Day 3 Was Associated With Sepsis-associated Liver Dysfunction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As defined by sepsis 3.0, sepsis is a clinical syndrome caused by disordered host response to serious infection，leading to multiple organ dysfunction1. Sepsis-associated liver dysfunction (SALD) is one of the most frequently complication in sepsis, possessing high morbidity and mortality2. A close relationship exists between the gut and the liver, … |
CHINESE MEDICAL ASSOCIATION | 2023-01-01 |
| 279 | A Randomized, Double-blind, Placebo-controlled, Phase 2a Study to Evaluate The Safety and Efficacy of Zetomipzomib (KZR-616) in Patients With Autoimmune Hepatitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2a, multi-center, placebo-controlled study in which patients with autoimmune hepatitis will receive zetomipzomib or placebo in addition to standard-of-care for 24 weeks. |
CRAIG LAMMERT; | 2023-01-01 |
| 280 | The Impact of Hepatic Steatosis on Chronic Hepatitis B Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the prevalence and severity of hepatic steatosis in CHB and investigate the relationship between hepatic steatosis and viral load, liver biochemistry, liver fibrosis, and inflammation in CHB |
MONA MOHAMMED ABDELRHMAN; | 2023-01-01 |
| 281 | Impact of Hepatitis B Immunoglobulins in Patients With Chronic Hepatitis B on Hepatocellular Carcinoma Related Papers Related Patents Related Grants Related Experts View Highlight: In the current literature, infection with the hepatitis B virus (HBV) is described as one of the main risk factors for the development of hepatocellular carcinoma (HCC). According to the current study situation, the Hepatitis B surface antigen (HBsAg) is considered as an important marker, since low levels and sero-clearance of HBsAg are both correlated with a lower risk of HCC development / recurrence.Currently there is no treatment option available that efficiently targets HBsAg. Besides neutralizing infectious HBV virions, Hepatitis B immunoglobulins (HBIG) can directly bind and neutralize extracellular HBsAg/SVPs, and even intracellular HBsAg targeting is reported. In addition, … |
MEDICAL UNIVERSITY OF GRAZ | 2023-01-01 |
| 282 | Single-Cell Profiling of Liver-infiltrating Immune Cells of Patients with NASH- and Virus-related HCC: Implications for Immunotherapy Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the the immune landscape of HCC arising from different etiology, such as MASLD and viral hepatitis, at single cell level. The main question it aims to answer is: Which are the immune signatures and pathways linked to MASLD- or virus-related HCC and what could be the best targets for immunotherapy? |
STEFANIA MANTOVANI; | 2023-01-01 |
| 283 | Comparison of Hepatus and FibroScan for Evaluation of Fibrosis and Steatosis in Chronic Hepatitis B or NAFLD Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Totals of 400 chronic hepatitis B or non-alcoholic fatty liver disease (NAFLD) patients with or without cirrhosis will be enrolled. Patients’ clinical characteristics, including alanine aminotransferase, aspartic aminotransferase, total bilirubin, direct bilirubin, indirect bilirubin, triglyceride and total cholesterol, hepatitis B surface antigen, steatosis, and liver stiffness measurement will be collected. The consistence of liver fibrosis and steatosis assessment between Hepatus and FibroScan will be evaluated in this study. |
HONG YOU; | 2022-12-29 |
| 284 | Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules As Enhancers of Bone Formation in Bone Grafting PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate bone formation in grafts in terms of its quality (density), quantity (volume) and maturation obtained with the application of a tissue-engineered bone grafting compound containing concentrated autogenous cell-culture medium (CM) and a synthetic bone substitute. The present study was designed as an experimental prospective split-mouth randomized controlled clinical trial. After protocol approval by the Research Ethics Committee, a total of 20 consecutive participants in need of maxillary reconstruction aiming implant-supported oral rehabilitation will be invited to join the study. To collect autogenous adipose tissue-derived mesenchymal stem cells (hASCs), … |
EDUARDO ROLIM TEIXEIRA; | 2022-12-15 |
| 285 | A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-escalation, Proof-of-Concept Study Evaluating The Safety, Tolerability, Efficacy and Pharmacokinetics of INT-787 in Subjects With Severe Alcohol Associated Hepatitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to assess dose related safety, early efficacy, pharmacokinetics and pharmacodynamics of INT-787 in patients with severe alcohol-associated hepatitis (sAH). |
PAUL THULUVATH; | 2022-12-15 |
| 286 | A Single-center Study of The Synergistic Effect of Portal Venous Supply Control and Immunotherapy in Hepatocellular Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatocellular carcinoma is one of the most common solid malignant tumors. The prognosis of unresectable hepatocellular carcinoma is very poor. According to the current literature and the clinical practice of our center, portal vein blood supply control may have great potential in the synergistic treatment of unresectable hepatocellular carcinoma. Thus, we hope to study the safety and efficacy of portal blood supply control +TACE+ Camrelizumab + Apatinib combined therapy in initial unresectable hepatocellular carcinoma through a single-center clinical trial, and explore the synergistic effect of portal blood flow control in target immune therapy of hepatocellular carcinoma. |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2022-12-14 |
| 287 | Building Up The Vaginal Flora Using Multistrain Probiotics in Patients with Bacterial Vaginosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of the study is to clarify whether and to what extent the consumption of the multistrain probiotic OMNi-BiOTiC® FLORA plus+ has a positive effect on the vaginal flora and reduces BV. This is determined using the Nugent score and the blackbird criteria. In one subgroup, the composition of the vaginal microbiome is analysed using 16S rRNA gene sequencing. |
DORIS MARIA GRUBER; | 2022-12-12 |
| 288 | Phase 3 Multicenter, Randomized, Double-Blind, Study to Assess The Efficacy and Safety of Treatment With Bepirovirsen in Nucleos(t)Ide Analogue-treated Participants With Chronic Hepatitis B Virus (B-Well 1) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is intended to confirm the efficacy, safety, pharmacokinetic (PK) profile, and the durability of hepatitis B virus surface antigen (HBsAg) suppression observed with bepirovirsen for 24 weeks (with loading doses) as compared to the placebo arm. This study will have 4 stages: a) Double-blind treatment (bepirovirsen or placebo) for 24 weeks. b) Nucleos(t)ide analogue (NA) treatment for 24 weeks. c) NA cessation stage OR Continue NA for 24 weeks. d) Durability of response and follow up for further 24 weeks for participants who stopped NA treatment at Week 48. The arms will be stratified based on HBsAg level (HBsAg greater than or equal to \[≥\] 100 international unit per milliliter \[IU/mL\] to less than or equal \[≤\]1000 IU/mL or greater than \[\>\] 1000 IU/mL to ≤3000 IU/mL) at screening. The total duration of the study, including screening (up to 60 days), the double-blind treatment stage (24 weeks), the On NA only stage (24 weeks), and the NA cessation and durability stages (48 weeks) is up to approximately 104 weeks at maximum for each participant. |
GLAXOSMITHKLINE | 2022-12-07 |
| 289 | A Randomized, Crossover Study Comparing Adherence, Preference + Acceptability of A Dual Prevention Pill (DPP) Capsule Containing PrEP + An Oral Contraceptive Versus Two Separate Pills in Women at Risk of HIV in Harare, Zimbabwe PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study design is a single-site, two-arm, randomized, open-label crossover trial in 30 AGYW aged 16-24 in Chitungwiza (Harare), Zimbabwe. The aim of the study is to assess the acceptability of, preference for, and adherence to a single DPP capsule containing one PrEP tablet and one COC tablet compared to two separate tablets (FTC/TDF and EE/LNG), each taken for three consecutive menstrual cycles for a total of 24 weeks among current COC users. |
NYARADZO M MGODI; | 2022-12-07 |
| 290 | Establishment of A Clinical Diagnostic Model GAMAD for Early-stage HCC Based on A Multilocus Blood-based Assay Targeting Circulating Tumor DNA Methylation: A Case-control Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Most hepatocellular carcinoma (HCC) cases were at advanced stage when diagnosis established. This study is intended to establish a clinical diagnostic model GAMAD for early-stage HCC and evaluate the diagnostic efficiency the same time. This study is a multicenter case control study. Participants including healthy control,HCC, liver cirrhosis, hepatitis and benign tumor-like lesions are consecutively recruited into the cohort. All the blood samples are collected before any treatments and will be tested in single center in order to decrease bias. |
GUOYUE LV; | 2022-12-01 |
| 291 | APPROACH 2.0: HIV, HCV and Syphilis Testing Through Pharmacies PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Human Immunodeficiency Virus (HIV), hepatitis C (HCV), and syphilis are sexually transmitted and blood borne infections (STBBI) that affect millions of people worldwide and rates are rising in Canada. HCV and syphilis are curable, and HIV is treatable with virtually no risk of transmission to sexual partners when the infection is controlled, however, these outcomes require adequate testing. Unfortunately, an estimated 44% of Canadians living with HCV and 13% living with HIV are not diagnosed. These undiagnosed cases are the source of over half of new HIV infections. Furthermore, … |
DEBORAH KELLY; | 2022-12-01 |
| 292 | A Randomized, Double-blind, Multicenter, Multinational, Active-controlled, Parallel-designed Phase 3 Clinical Trial to Evaluate The Immunogenicity and Safety of Inactivated Hepatitis A Vaccine in Healthy Children Aged From 24months to 15yrs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate immunogenicity and safety of inactivated hepatitis A vaccine in healthy children aged from 24 months to 15 years when administered an initial dose followed by a booster dose (a total of 2 doses administered with 6 months interval). |
BORYUNG BIOPHARMA | 2022-12-01 |
| 293 | Prospective Observational Immunogenicity Trial of Gardasil-9 HPV Vaccine in People Living With Adequately Managed HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to determine the magnitude and breadth of the serum antibody response to the nonavalent HPV vaccine (Gardasil-9) in adults with well-controlled HIV infection. The secondary objectives of the study are to observe short term clinical outcomes of prevalent HPV genotype-specific anogenital infections in adults living with HIV who complete the three-dose Gardasil-9 vaccine series, … |
JENNIFER CAMERON; | 2022-11-30 |
| 294 | Health Systems Innovations for Supporting Transitions of Care for Incarcerated People Living With HIV, Hepatitis C, and Substance Use Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to enroll 220 incarcerated individuals living with HIV, Hepatitis C (HCV), or history of substance misuse preparing for release into a pilot implementation study to test the feasibility and acceptability of an adapted Coordinated Transitional Care intervention in a Criminal Justice setting (CJC-TraC). Participants can expect to be on study for up to 6 months. |
RYAN WESTERGAARD; | 2022-11-29 |
| 295 | Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of HT-101 Injection in Healthy Subjects and Patients with Chronic Hepatitis B Virus Infection: A Randomized, Double-blind, Placebo-controlled, Single and Multiple Doses, and Dose Escalation Phase 1 Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase 1 Study of HT-101 in Healthy Subjects and Patients With Chronic Hepatitis B The trial consisted of two components. Part A involved a single ascending dose study where healthy participants were administered one dose of HT-101 or placebo subcutaneously (SC). Part B involved a multiple ascending dose study where participants with chronic hepatitis B virus infection were administered two dose of HT-101 or placebo every 4 weeks subcutaneously (SC). |
SUZHOU HEPATHERA BIOTECH | 2022-11-22 |
| 296 | Evaluation of Novel Hepatitis B DNA Test from Capillary Blood At The Point-of-care As A Tool to Enhance Clinical Management PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a cross sectional observational study to asses the performance of two novel HBV DNA testing methodologies; a) dried blood spot sampling and b) fingerstick capillary blood using the Xpert® Hepatitis B Virus viral load assay. Both novel testing methodologies will be compared with venous blood tested using a gold standard HBV DNA assay. The sensitivity and specificity of the two novel testing will be evaluated. HBV viral load tests are essential to guide antiviral treatment eligibility and effectiveness. However, many people are unable to access these tests, … |
GAIL V MATTHEWS; | 2022-11-17 |
| 297 | Eliminación De La Infección Por El Virus De La Hepatitis C En PWID En Los Estados Del Norte De México PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Substance users are a vulnerable group that should be prioritized in HCV (Hepatitis C Virus) elimination efforts in Mexico and in which it is feasible to carry out micro-elimination programs. It is an important group to treat both because of its high prevalence and because of the dynamic spread of infection among the general population. HCV seropositivity has not been documented in this group of people in Mexico City, the metropolitan area and the northern states of the country, nor has the sustained viral response been evaluated in this group of patients in the Mexican population. |
GRACIELA ELIA CASTRO NARRO; | 2022-11-15 |
| 298 | A Phase IIa Study to Evaluate The Efficacy and Safety of ZM-H1505R in Combination With Entecavir (ETV) Compared With ETV Monotherapy in Patients With Chronic Hepatitis B Who Have Received ETV Monotherapy for at Least 12 Months PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled phase IIa study, designed to evaluate the efficacy and safety of ZM-H1505R in combination with Baraclude versus Baraclude monotherapy in adult CHB subjects with HBV DNA <2000 IU/mL but ≥ 50 IU/mL and who have received ETV (0.5 mg, once daily [QD)] monotherapy for at least 12 months. The study is planned to enroll 90 adult CHB subjects who have received ETV monotherapy for at least 12 months and are still receiving ETV monotherapy (0.5 mg, ... |
JUNQI NIU; | 2022-11-15 |
| 299 | A Phase 1, Blinded, Placebo-Controlled Study of The Safety, Tolerability, Pharmacokinetics of Single and Multiple Ascending Doses of ABI-4334 in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to assess safety, tolerability, and PK of single ascending doses (SAD) of ABI-4334 in Part A and multiple-ascending doses (MAD) of ABI-4334 in Part B in healthy subjects. Effect of food will also be evaluated in Part A. |
EDWARD GANE; | 2022-11-11 |
| 300 | HCV Test and Treat Utilizing Simplified HCV Patient Education Related Papers Related Patents Related Grants Related Experts View Highlight: The study hypothesis is that the test and treat model utilizing video-based patient education will have higher rates of hepatitis C virus (HCV) treatment initiation and treatment completion. |
ROBERT S BROWN; | 2022-11-11 |
| 301 | ABO Blood Group Type Association With COVID-19 Severity – A Single Center Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic has caused a significant healthcare burden and remains a heavily researched disease entity. Originating in Wuhan, China in late 2019, SARS-CoV-2 has infected over 600 million individuals worldwide. ABO blood groups have been known to increase the human body’s susceptibility to different pathogens, such as hepatitis B virus, MERS-COV, SARS-COV, norovirus, and malaria, to name a few. As such, the association of ABO blood groups and COVID-19 infection and disease severity has come into question. |
ARROWHEAD REGIONAL MEDICAL CENTER | 2022-11-10 |
| 302 | Prevalence and Burden of Hepatitis D Virus Infection in China Through Preoperative Examination Test (Predict Study) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: In China, there is no recommendation for Hepatitis D virus (HDV) screening, but the fact is estimated that one-third of the world’s population of individuals with chronic Hepatitis B virus (HBV) infection live in China while we do not know the prevalence of co-infection of HBV/HDV in China. So far, no nationwide study has been undertaken to evaluate the epidemiology of hepatitis D, on the other hand, reports of HDV infection rate in different regions of China are not consistent because of the different detection methods and detection objects. Here, … |
THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY | 2022-11-01 |
| 303 | A Randomized, Open-Label Study to Evaluate Potential Pharmacokinetic Interactions of Orally Administered Artemether-lumefantrine and Amodiaquine in Healthy Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label pharmacokinetic study in 16 healthy Thai subjects. To assess the safety and tolerability and pharmacological interactions of the combination of artemether-lumefantrine and amodiaquine. This study is funded by Prof White’s WT PRF. The grant reference number is B9R04920. |
UNIVERSITY OF OXFORD | 2022-11-01 |
| 304 | Discontinuation of Antiviral Therapy As A Strategy to Cure Hepatitis B PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cirrhosis or cancer of the liver caused by hepatitis B virus (HBV) are major global health problems. Chronic HBV infection has become more common in Sweden with immigration. The risk of cancer and the availability of effective antivirals has led to more and more people receiving long-term treatment with antiviral drugs. The disadvantages of this treatment are that it does not have a defined duration and that it very rarely leads to the cure. Several published studies suggest that a large proportion of patients who discontinue antiviral therapy after at least three years may achieve lasting cure of the infection or at least do not need to resume treatment. The mechanism of this effect is not known, but it is thought to be due to the fact that the immune response, which is activated when the amount of virus increases after the end of treatment, becomes more effective in eradicating infected liver cells than it was before starting treatment. As a consequence of these findings updated guidelines for treatment of hepatitis B state that for patients that have received nucleoside analogue treatment for \> 3 years, discontinuation is an accepted therapeutic alternative. The purpose of the planned study is to investigate the results of discontinued treatment, in terms of clinical outcome as well as immunological and virological mechanisms. The aim is to include 120 patients at four regional infectious diseases clinics (in Gothenburg, Borås, Skövde and Trollhättan), of which 90 will be randomized to discontinue and 30 to continue antiviral treatment. Blood samples will be taken regularly to monitor the outcome and for detailed studies of viral antigens and nucleic acid in the blood and for specific analyzes of the cells of the immune system. The goal is to understand why the discontinued treatment in some patients activates an effective immune response and how such an effect can be predicted even before or early after the treatment is stopped. |
GÖTEBORG UNIVERSITY | 2022-11-01 |
| 305 | Feasibility Study of The Kronos Electrocautery Device PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a clinical study designed to evaluate the performance of the Kronos Electrocautery Device used to reduce or prevent bleeding following a biopsy procedure in the liver and kidney. |
SINGLE PASS | 2022-11-01 |
| 306 | Pain and Crying Time in Hepatitis B Vaccine in Preterm Infants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many painful interventions that cause pain and stress are applied to preterm babies in the neonatal intensive care unit for diagnosis and treatment. In neonatal care and reduction of acute interventional pain; Non-pharmacological methods including behavioral, psychological and environmental regulations should be used. In the hepatitis B vaccine administered to preterm babies, stimulating the grasping reflex can make the preterm baby feel safe and calm. In the literature, there are many studies aimed at reducing pain in preterm newborns. However, … |
TÜRKAN KADIROĞLU; | 2022-11-01 |
| 307 | Dried Blood Spot Testing for At Home Health PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: DBS (Dried blood spot) is the collection of a small volume of blood on paper cards and subsequent transport to an analytical laboratory. This method is widely used for newborn screening programs around the world to identify inborn errors of metabolism where early diagnosis and treatment can be lifesaving. The World Health Organization and World Anti-Doping Agency (WADA) have independently endorsed DBS as an alternative to conventional testing methods due to its lessened invasiveness, lower collection and transport cost, reduction in sample storage needs, and for some analytes, … |
CHRISTOPHER MCCUDDEN; | 2022-10-31 |
| 308 | The Effect of High Oral Loading Dose of Cholecalciferol in Non-Alcoholic Fatty Liver Disease Patients. A Randomized Placebo Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of work The aim of our study is to assess the effectiveness and safety of high oral loading dose of inactive vitamin D supplementation on the clinical parameters related to liver steatosis, glycaemic control, insulin resistance and metabolic profile in NAFLD patients |
RADWA EL BOROLOSSY; | 2022-10-31 |
| 309 | Clinical Correlation of Alpha-Fetoprotein in Hepatocellular Carcinoma: A Cross-Sectional Study from Southeast Asia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to explore the levels of alpha-fetoprotein (AFP), a protein often elevated in liver cancer, in patients with hepatocellular carcinoma (HCC). The goal is to determine whether AFP levels vary based on the size of the liver tumor or other health conditions like hepatitis B, hepatitis C, and obesity. By analyzing data from 94 patients, the study seeks to identify factors that influence AFP levels, which may help in understanding liver cancer progression and improving diagnosis and treatment approaches. |
MARYAM ABBASI; | 2022-10-30 |
| 310 | Validation of The New Vibration-guided FibroScan Examination PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an European, prospective, interventional, multicenter clinical investigation that will take place in 2 French sites. 100 adults patients will be included. The study objective is to compare the applicability between the Research FibroScan and the reference FibroScan examination performed on the liver. |
LAURENT CASTERA; | 2022-10-26 |
| 311 | A Phase 1/ 2a, Multicenter Study of SCG101 in The Treatment of Subjects With Hepatitis B Virus-Related Hepatocellular Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase 1/ 2a study is a multicenter study to evaluate the safety, tolerability and efficacy of SCG101 in subjects with hepatitis B virus-related hepatocellular carcinoma |
SCG CELL THERAPY PTE | 2022-10-26 |
| 312 | The Effect of Two Different Methods on Infant Pain During Vaccination and Maternal Anxiety: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research was planned to determine the effect of two different methods on infant pain during vaccination and mother anxiety.The study was planned as a randomized controlled trial. The universe of this research consists of parents and their babies who come to Hocabey Family Health Center in Erzincan Center to receive the hepatitis B dose between these dates according to the vaccination calendar. In this study, it is planned to apply shotblocker and lullaby. |
ARZU SARIALİOĞLU; | 2022-10-25 |
| 313 | Platelets Indices and Its Role to Predict Liver Fibrosis in Patients With Chronic Hepatitis B Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Patients with chronic Hepatitis B infection will be collected and will do liver fibroscan to predict the degree of liver Fibrosis and correlate between the role of platelets count … |
WAFAA ADEL ABDELGHANY; | 2022-10-20 |
| 314 | Is There A Response of Hepatic Enzymes, Psychological Measures, and Sexual Dysfunction to Aerobic Exercise in Men With Sexual Dysfunction Complaint and Hepatitis C PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic hepatitis C virus (HCV) infection is a systematic disease that affects several aspects of patients’ well-being, including physical, mental, social, and sexual quality of life. In recent years, this clinical trial aims to search the Response of Hepatic Enzymes, Psychological Measures, and Sexual Dysfunction to Aerobic Exercise in Hepatitis Men With Sexual Dysfunction Complaint |
ALI MOHAMED ALI ISMAIL; | 2022-10-15 |
| 315 | SIRI Checklist: An Integrated Hospital Model to Optimize HIV Prevention in Persons Who Inject Drugs PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop and test a serious injection-related injections (SIRI) checklist aimed at increasing evidence-based treatment for rural people who use drugs (PWUD) including innovative, long-acting injectable agents. The central hypothesis is that hospital-based care models can successfully engage rural and Southern (PWUD) in effective addiction treatment and infection prevention. The activities in this study will be foundational to Ending the HIV epidemic in rural states. |
ELLEN EATON; | 2022-10-11 |
| 316 | Viral Hepatitis and Gallstone Disease Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to investigate possible associations between ongoing viral hepatitis (i.e. hepatitis A, B, C or E virus infection) and ultrasound or computed tomography-verified gallstone disease. |
MARTIN LAGGING; | 2022-10-07 |
| 317 | A Randomized, Open-label, Multicenter, Phase II Clinical Trial to Evaluate The Efficacy and Safety of HR19042 Capsules in The Treatment of Autoimmune Hepatitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the efficacy and safety of HR19042 capsules for the treatment of autoimmune hepatitis. It will also explore the optimal frequency and dosage of HR19042 capsules administration for the treatment. |
JIANGSU HENGRUI MEDICINE | 2022-10-06 |
| 318 | Non-invasive Prediction of Esophageal Varices in Patients With Non-Alcoholic Fatty Liver Disease With Advanced Fibrosis; A Single Centre United Arab Emirates Experience PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-alcoholic fatty liver disease (NAFLD) is defined as accumulation of fat in the liver which is not related to either alcohol excess or other causes such viral infection, immune-mediated, or medication related which can lead to fibrosis and later-on, cirrhosis. Over the last years NAFLD related liver cirrhosis has become the commonest cause of chronic liver disease worldwide. Portal hypertension is the major complication caused by increased splanchnic blood flow which leads to development of oesophageal varices (OV). Almost all of the patients with portal hypertension can develop OV sometime in their life and one third of those will bleed, … |
ADNAN AGHA; | 2022-10-05 |
| 319 | A Phase I/IIa, Open-label, Randomised, Controlled, Multi-country, Dose-escalation Study to Assess The Safety and Immunogenicity of AS37 in Combination With The Hepatitis B Surface Antigen (HBsAg), According to A 0-1 Month Schedule, in Healthy, HBs Naïve, Adults Aged 18-45 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is conducted to assess safety and immunogenicity of GSK’s HBsAg vaccine adjuvanted with GSK’s AS37 adjuvant system in healthy, HBs naïve, adults aged 18-45 years and to differentiate GSK’s AS37 adjuvant system from other approved adjuvant systems and from an aluminum-based adjuvant. |
GLAXOSMITHKLINE | 2022-10-04 |
| 320 | Immunogenicity and Safety Following In-House Recombinant Hepatitis B (Bio Farma) Vaccine Compared to Hepatitis B (Bio Farma)® Vaccine in Indonesian Population PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 3 study, experimental, randomized, double blind, four arm parallel group study, lot to lot consistency. |
TRISNA WINDIANI; | 2022-10-01 |
| 321 | Comparison of Immunogenicity and Safety of DTP-HB-Hib Using New Hepatitis B Bulk (Bio Farma) With Pentabio® Vaccine Primed With Recombinant Hepatitis B at Birth Dose Using New Hepatitis B Bulk (Bio Farma), in Indonesian Infants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This bridging study is a randomized, double-blind, two arms parallel group, prospective intervention study. The primary objective of this study is to evaluate protectivity of DTP-HB-Hib Vaccine (Bio Farma) using new Hepatitis B bulk (Bio Farma). |
EDDY FADLYANA; | 2022-10-01 |
| 322 | A Pilot Two-arm, Individual-level, Randomised Controlled Trial to Assess The Effect of An Intervention Integrating Contingency Management (Financial Incentives) to Enhance Hepatitis C Treatment Uptake Following Dried Blood Spot Hepatitis C RNA Testing Among People With Recent Injecting Drug Use Attending Needle and Syringe Programs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A pilot two-arm, individual-level, randomised controlled trial to assess the effect of an intervention integrating contingency management (financial incentives) to enhance hepatitis C treatment uptake following dried blood spot hepatitis C RNA testing among people with recent injecting drug use attending needle and syringe programs: the AMPLIFY study |
KIRBY INSTITUTE | 2022-10-01 |
| 323 | Association of Serum Interleukin -6 and Transforming Growth Factor Beta Levels With Response to Antiviral Therapy for Chronic Hepatitis C Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C virus (HCV) infection is associated with significant morbidity and mortality owing to progression of a high percentage (85%) of HCV infected patients to chronic hepatitis, which might lead to the development of liver cirrhosis or hepato cellular carcinoma.. Egypt has possibly the highest HCV prevalence in the world, 10-20% of the general population . |
HAYAM HAMDY MAHMOUD; | 2022-10-01 |
| 324 | Safety and Efficacy of TRPP Therapy in Glioblastoma Multiforme PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the safety of an innovative integrated treatment regimen for recurrent glioblastoma , including patients with recurrent glioblastoma multiforme. |
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIVERSITY | 2022-10-01 |
| 325 | Role Of Serum Adiponectin In The Ealy Detection Of Renal Impairment In Patients With Non Alcoholic Fatty Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Early detection of renal impairment in patients with Non-alcoholic fatty liver disease and its correlation with serum Adiponectin level. |
MUSTAFA ABDELRAFE SAYED; | 2022-10-01 |
| 326 | A Multi-Site Leukopak Repository Providing Annotated Biospecimens for Approved Investigator-Directed Biomedical Research Initiatives PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: To collect, preserve, and distribute annotated leukopak biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and preventative methods for specific and complex conditions. This protocol will be utilized to collect research grade products that are not meant for transfusion. |
TIMOTHY TRICHE; | 2022-09-28 |
| 327 | A Phase 2b, Open-label Study to Evaluate The Efficacy, Safety, Tolerability, Immunogenicity and Treatment Regimens of VTP-300 Combined With Low-dose Nivolumab in Chronic Hepatitis B Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label study to determine the efficacy, safety, tolerability and immunogenicity of ChAdOx1-HBV and MVA-HBV, together VTP-300, in combination with low-dose nivolumab, in patients with chronic HBV who are virally suppressed with oral anti-viral therapies. |
VACCITECH UK | 2022-09-21 |
| 328 | Non-invasive Diagnosis of Portal Hypertension in Cirrhosis Based on Metabolomics Technology(CHESS2207): A Prospective, Multicenter Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Portal hypertension (PH) is a group of syndromes characterized by abnormal changes in the portal blood flow system, mostly caused by cirrhosis. It is an important factor affecting the clinical prognosis of cirrhotic patients, and its severity determines the occurrence and development of cirrhotic complications. Clinically, measurement of portal venous pressure directly is highly invasive, and factors such as intra-abdominal pressure changes can interfere with the results, limiting its clinical application. Hepatic venous pressure gradient (HVPG) is the gold standard for assessing PH in cirrhosis. The normal range of HVPG is 3~5 mmHg, … |
XIAOLONG QI; | 2022-09-15 |
| 329 | A Randomized, Crossover Study Comparing Adherence, Preference + Acceptability of A Dual Prevention Pill (DPP) Capsule Containing PrEP + An Oral Contraceptive Versus Two Separate Pills in Women at Risk of HIV in Johannesburg, South Africa PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, crossover study to compare adherence, preference and acceptability of an over-encapsulated dual prevention pill (DPP capsule) containing oral pre-exposure prophylaxis (PrEP) and a combined oral contraceptive (COC) versus two separate tablets (PrEP and COC) among women at risk of HIV and unintended pregnancy in Johannesburg, South Africa |
THESLA PALANEE-PHILLIPS; | 2022-09-13 |
| 330 | CRIBADO DE VIRUS DE LA HEPATITIS C En Hombres Que Tienen Sexo Con Hombres (HSH) Sitges PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study aimed at determining the prevalence of hepatitis C in a specific population: men who have sex with men. |
SONIA ALBERTOS; | 2022-09-09 |
| 331 | Efficacy of N-acetylcysteine to Prevent Anti-tuberculosis Drug-induced Liver Injury: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the efficacy of NAC to prevent clinically significant anti-TB drugs induced liver injury (AT-DILI). |
WATCHARASAK CHOTIYAPUTTA; | 2022-09-09 |
| 332 | Prevalence of Significant Liver Fibrosis and Inflammation in Chronic HBV Infected Patients in Grey Zone PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To explore whether normal alanine aminotransferase (ALT) is associated with liver injury in a cohort of hepatitis B virus (HBV) infected patients in grey zone |
WANG HUI; | 2022-09-01 |
| 333 | The Observational Study of COVID-19 Infection and Its Clinical Prognosis in Chronic Hepatitis B Patients With Antiviral Therapy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a two-way (retrospective and prospective) study of COVID-19 infection in an observational cohort of patients with chronic hepatitis B treated with antiviral therapy. Patients with chronic hepatitis B who received anti-HBV treatment in the Second Department of Hepatology, Beijing Ditan Hospital Affiliated to Capital Medical University from February 2022 to December 2023 were enrolled. After enrollment, demographic data of patients, information on antiviral treatment of chronic hepatitis B, COVID-19 vaccination, COVID-19 infection and COVID-19 incidence and treatment from January 2022 to pre enrollment, and data on HBV virus and serology, clinical biochemistry, liver and lung imaging, … |
YAO XIE; | 2022-09-01 |
| 334 | Efficacy and Safety of Sofosbuvir/Velpatasvir Plus Ribavirin for 12 Weeks or Sofosbuvir/Velpatasvir/Voxilaprevir for 12 Weeks in DAA Treatment Naïve HCV Subjects With GT3b, Compensated Cirrhosis in China PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Direct-acting antiviral agents (DAAs) targeting HCV have revolutionized the treatment of HCV. The efficacy of DAA-based therapy can depend on patient-related factors such as treatment experience, cirrhosis, but also on viral genotype. The high prevalence of genotype 3, which is considered difficult to cure, remains a challenge because many oral DAAs are less effective for this genotype, particularly subtype 3b than for others. Current guidance generally recommends sofosbuvir (SOF)/velpatasvir (VEL) ± ribavirin (RBV), glecaprevir/pibrentasvir and SOF/VEL/voxilaprevir (VOX) as first-line therapy for genotype 3, and an interferon-based regimen – … |
HUIYING RAO; | 2022-09-01 |
| 335 | A Spectrum of Hematological Disorders in Children Presented With Pancytopenia at Assiut University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the spectrum of pancytopenia with its frequency and etiology in children presenting to Assiut University Children Hospital during one year |
ZAKRIA YOUNES MOHAMMED ESSEMY; | 2022-09-01 |
| 336 | Efficacy of Serious Game Interventions on Hepatitis C Education for HIV-Positive Men Who Have Sex With Men: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C transmission has a high rate of infection and re-infection among PLWH men who have sex with men (MSM), and co-infection increases liver and HIV morbidity. The MSM group has a low level of awareness and perception of hepatitis C, and lacks health beliefs and prevention behaviors about hepatitis C. In the absence of hepatitis C cognition and health belief, it should be possible to use the health belief model to intervene and design teaching programs to improve the effectiveness of hepatitis C prevention and treatment. In the past, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2022-09-01 |
| 337 | Adherence to Guidelines VAccination in Type 1 DIabetes Mellitus Patients (AVADI-2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Observational study about adherence to guidelines for Covid-19, Influenza, Pneumococcal and Hepatitis B Vaccination in adult patients with type 1 Diabetes mellitus. |
CASTILLA LA MANCHA HEALTH SERVICE | 2022-09-01 |
| 338 | Peginterferon Alfa-2b Combined With Tenofovir Alafenamide Improves The Functional Cure Rate in Patients With HBeAg Negative Chronic Hepatitis B: An Open-labeled, Multicenter, Randomized and Controlled Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is aimed to explore the safety and efficacy of the pulse usage , comparing to continuous usage, of Peginterferon alfa-2b Injection (PEG IFN α-2b) Combined With tenofovir alafenamide (TAF) in treatment of naive chronic hepatitis B patients with HBeAg negative. |
JIMING ZHANG; | 2022-09-01 |
| 339 | Intrafamilial Transmission of Hepatitis B Virus: Frequency, Risk Factors, and Role of Hepatitis B Vaccination PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of the study is to accomplish two major tasks: the first is to determine the frequency of intra-familial transmission of HBV; the second is trying to explore the potential risk factors of such a transmission .As a secondary aim, immunologic status of the household contacts vaccinated for hepatitis B will be evaluated to assess the efficacy of hepatitis B vaccination and its role in prevention of intra-familial transmission of HBV |
MOHAMED FAIK HAMED AHMED; | 2022-09-01 |
| 340 | Human Leucocytes Bank From COVID-19 Cured Patients With A Cellular Immunity Against SARS-CoV-2 :Raw Material for The Preparation of An Anti-SARS-CoV-2 Cellular Immunotherapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The SARS-CoV-2 identified in China in January 2020 is the cause of an unprecedented pandemic. The SARS-CoV-2 and each viral variant are responsible of a respiratory infectious disease, which can be asymptomatic. Nevertheless, … |
LEFEVRE BENJAMIN; | 2022-09-01 |
| 341 | Impact of Early Antibiotic Therapy on Vaccination Response in Preterm Infants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Since the neonatal sepsis is still one of the most common causes of death in preterm infants up to 80% receive an perinatal antibiotic treatment. It is also known that an antibiotic treatment is one of the most important influences for the establishment of the intestinal microbiome. This again is important for the development of an healthy neonatal immunosystem. A pilot study showed that an antibiotic therapy in the first week of life had a negative influence on the vaccine titers of preterm infants. In this study it will be further investigated if an early antibiotic treatment influences the development of the adaptive immunosystem in preterm infants and if this antibiotic treatment effects the development of the intestinal microbiome. |
UNIVERSITY HOSPITAL TUEBINGEN | 2022-09-01 |
| 342 | A Randomised Controlled Phase 1 Study of Vaccine Therapy for Control or Cure of Chronic Hepatitis B Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study to determine the safety and efficacy of a novel adjuvanted hepatitis B virus (HBV) vaccine formulated as a potential therapeutic vaccine against chronic HBV infection. An ongoing human clinical trial of this HBV vaccine in a prophylactic setting has confirmed this vaccine to be more effective at inducing seroconversion as measured by development of Hepatitis B surface antibody (HBsAb) in poor responder subjects than the standard alum-adjuvanted HBV vaccine, providing promise that this new vaccine may also be able to induce HBV viral control and/or seroconversion in chronically infected subjects |
KATE MULLER; | 2022-09-01 |
| 343 | The Efficacy of Laser Acupuncture on The Diabetes-induced Peripheral Neuropathy: Basic and Clinical Research PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetic peripheral neuropathy (DPN) is one of the microvascular complications of diabetes mellitus. This can lead to painful and costly clinical sequelae such as foot ulcers, amputation, and neuropathic pain. There are several novel diagnostic methods available for complementary to clinical assessment and may help in the early detection of DPN. However, treatments for DPN and painful DPN are limited. We will conduct a pilot, single-center, randomized controlled trial in patients with DPN to verify the effect of the laser acupuncture on DPN. With designed inclusion and exclusion criteria, … |
YU CHEN; | 2022-08-31 |
| 344 | Burden of Hepatitis D Virus (HDV) Infection in Italy: A Prospective/Observational Multicenter Study to Define Demographic, Clinical and Virological Features PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The circulation of the Hepatitis D Virus (HDV) has considerably diminished in Italy, secondary to the control of the Hepatitis B Virus (HBV) with vaccination; this has led to the perception that HDV is vanishing and has reduced attention to the diagnosis of Hepatitis D. However, migratory fluxes from HDV endemic areas, fostered by labour-forces globalization, … |
MARIO RIZZETTO; | 2022-08-24 |
| 345 | Prospective Cohort Study to Determine Effectiveness of Telemedicine-based on Site Hepatitis C Management in Probation and Parole Office PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective cohort study compares aims to determine the efficacy and effectiveness of telemedicine-supported on-site linkage to care and treatment in a community probation and parole office (P\&P office) setting and compare the results with a historic control with referral to care. Research participants will be followed in the P\&P office when they report to their officer during regularly scheduled appointments. Participants will receive treatment without having to travel to a specialist’s office. The telemedicine visit will include a consultation with an experienced HCV provider such as a hepatologist or an advanced practice provider and a specialty pharmacist who will educate about and monitor HCV treatment. The UK specialty pharmacy will be available to participants and the HCV management team through a 24-hour support line. Participants will be treated per HCV guidelines and insurance preference. |
JENS ROSENAU; | 2022-08-23 |
| 346 | A Phase II of Randomized, Double-blind, Placebo-controlled, Multi-center Study of Hepalatide for Injection Combined With Pegylated Interferon and TAF As Finite Treatment in Chronic Hepatitis B Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is designed to assess efficacy of a finitie treatment in Chronic Hepatitis B patients who had stable treatment of NAs for ≧ 2 years， which is compared hepalatide in combination with Pegylated Interferon + TAF with Pegylated Interferon +TAF. Subjects will be randomly assigned to the hepalatide or placebo groups , 15 subjects in each group . Subjects will receive hepalatide+Pegylated Interferon +TAF treatment for 48 weeks or placebo +PegylatedInterferon +TAF treatment for 48 weeks , Then, stopping all treatments and followed with further 24 weeks follow-up. |
QIN ZHANG; | 2022-08-23 |
| 347 | Three-dimensional MR Elastography and Two-dimensional MR Elastography for Assessing Cirrhosis and Portal Hypertension：A Prospective Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: How to construct a novel, non-invasive, accurate, and convenient method to achieve prediction of hepatic venous pressure gradient (HVPG) is an important general problem in the management of portal hypertension in cirrhosis. We plan to compare the ability of three demensional-magnetic resonance elastography (3D-MRE) to two demensional-magnetic resonance elastography (2D-MRE) to establish a risk stratification system and perform tailored management for portal hypertension in cirrhosis. |
YU SHI; | 2022-08-16 |
| 348 | Three-dimensional MR Elastography for Assessing Cirrhosis and Portal Hypertension (CHESS2206): A Prospective Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: How to construct a novel, non-invasive, accurate, and convenient method to achieve prediction of hepatic venous pressure gradient (HVPG) is an important general problem in the management of portal hypertension in cirrhosis or advanced chronic liver disease. We plan to investigate the ability of three demensional-magnetic resonance elastography (3D-MRE) to establish a risk stratification system and perform tailored management for portal hypertension in cirrhosis or advanced chronic liver disease. |
YU SHI; | 2022-08-16 |
| 349 | RegoFlex EU/Real World Evidence on Stivarga Flexible Dosing in Patients With Metastatic Colorectal Cancer in Europe PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study in which data from patients with metastatic colorectal cancer in three European countries who received STIVARGA® (regorafenib), are collected. In observational studies, only observations are made without specified advice or interventions. Metastatic colorectal cancer (mCRC) is a cancer that starts in the large bowel or the rectum (the lowest part of the gut) and has spread to other parts of the body. Regorafenib is an anti-cancer drug that blocks several proteins called enzymes, … |
BAYER | 2022-08-15 |
| 350 | Hepatitis B Immunoglobulins to Induce HBsAg Clearance in Patients with Chronic Hepatitis B (HBIG for Cure) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label, single arm (two cohorts), single-center, phase II pilot-study to provide preliminary evidence whether hepatitis B immunoglobulins (HBIG) are efficacious and can be safely used in patients with chronic Hepatitis B Virus (HBV) infection. A total of 20 patients (male or female adults aged ≥ 18 years) will be enrolled in the study and receive hepatitis B immunoglobulins Hepatect®CP and Zutectra®. |
HEINER WEDEMEYER; | 2022-08-15 |
| 351 | Nasal Immune Challenge Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Respiratory viral infections cause significant illness, especially in vulnerable individuals and is a topic of immense significance during the current COVID-19 global pandemic. Respiratory diseases such as asthma involve inflammation of the airways and viruses are a major cause of asthma attacks. The nose is easier to access than the lungs but has similar cells and is therefore useful to study immune responses throughout the respiratory tract. Rather than study the effects of a live virus on the immune system, … |
AKHILESH JHA; | 2022-08-09 |
| 352 | Immune Function and Response to Vaccination Following Completion of Cancer Directed Systemic Therapy in Pediatric Patients With Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pediatric cancer survivors have increased infection-related morbidity and mortality. This study will evaluate immune dysfunction following cancer directed systemic therapy completion, with attention to clinical relevance and infection rate in this population compared to healthy siblings, when applicable. The investigators will also restart vaccinations at earlier time points than previously studied, at 3 months post therapy, and will assess whether boosters or revaccination schedules are superior for regaining immunity against potentially serious infections in survivors. |
ASHLEY HINSON; | 2022-08-08 |
| 353 | A Randomized, Blinded, Placebo-Controlled, Dose-Ranging Phase 1b Study of The Safety, Pharmacokinetics, and Antiviral Activity of ABI-H3733 in Subjects With Chronic Hepatitis B Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, blinded, placebo-controlled, dose-ranging Phase 1b study of the safety, PK, and antiviral activity of ABI-H3733 in treatment-naïve or off-treatment chronic Hepatitis B virus (cHBV) subjects that are Hepatitis B e antigen (HBeAg) positive or negative. The study will enroll up to 5 sequential cohorts of 10 subjects each, for a total of up to 50 subjects, randomized 8:2 to receive ABI-H3733 or placebo. |
ASSEMBLY BIOSCIENCES | 2022-08-07 |
| 354 | Evaluation of Risk Factors for MASLD and Probability of Advanced Liver Disease in A The Romanian Arm of The The European Health Examination Survey (EHES) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the presence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) risk factors and estimate the probability of advanced liver disease in a Romanian cohort from the European Health Examination Survey (EHES). Using standardized clinical, anthropometric, and laboratory data, the study will assess metabolic and alcohol-related contributors to liver disease. The primary focus is to identify an at-risk MASLD population, characterize associated metabolic risk factors, … |
INTERNIST RO | 2022-08-01 |
| 355 | Relationship Between Different Types of COVID-19 Vaccine and Development of Immune Thrombocytopenic Purpura PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Detect development of immune thrombocytopenic purpura (ITP) after different types of (COVID-19) vaccination |
SHYMAA MOHAMED ISMAIL; | 2022-08-01 |
| 356 | Omics-based Predictors of NAFLD/Potential NASH: A New Era Towards Valid and Reliable Non-invasive Diagnosis and Personalized Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The cascade of care for the non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) requires crossing the barriers for their diagnosis and treatment. The multifactorial nature of NAFLD/NASH limits their diagnosis by a single factor solely. This project aimed at developing a powerful composite marker panel based on multi-omics technologies to detect NAFLD without or with fibrosis (potential for NASH) in high-risk populations (obesity, type 2 diabetes, hypertensive, … |
PROF.DR. AMMAL MOKHTAR METWALLY; | 2022-08-01 |
| 357 | Serum Levels of Some Trace Elements in Hepatocellular Carcinoma Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatocellular carcinoma (HCC) is the sixth most frequent malignancy worldwide, with an estimated 906,000 new cases and 830,000 deaths in 2020. It is also the third leading cause for cancer deaths, with 15% 5-year survival rate . Diagnosis of HCC in cirrhotic patients is mainly based on non-invasive imaging techniques. Multiphasic computed tomography (CT) and dynamic contrast-enhanced magnetic resonance imaging (MRI) are the most sensitive imaging techniques for diagnosis of HCC. While the most common serologic marker for early screening of HCC is alpha-fetoprotein (AFP) . Liver is the main site of trace elements metabolism, … |
AHMED ATEF FADEL IBRAHEM; | 2022-08-01 |
| 358 | The Importance of Bilirubin Molecular Species in Patients With Liver Cirrhosis Who Develop Hepatic Encephalopathy and Patients With Acute-on-chronic Liver Failure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It has been identified that impaired liver function, as occurs in patients with liver cirrhosis, prevents proper conjugation of glucuronic acid with bilirubin; as a result, unconjugated bilirubin accumulates in the blood, and conjugated bilirubin is markedly altered to form diglucuronides or monoglucuronides. However, in the development and progress of acute-on-chronic liver failure (ACLF) there is not enough information about these processes and the possible concentration levels that they can take. Also Hepatic encephalopathy (HE) is a reversible complication, but with a high mortality rate in patients with acute or chronic liver failure, … |
NAHUM MÉNDEZ-SÁNCHEZ; | 2022-08-01 |
| 359 | Atorvastatin Use and Portal Hypertension in Patients With Hepatitis B Virus-related Liver Cirrhosis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate whether atorvastatin can improve portal hypertension in patients with chronic hepatitis B related compensated cirrhosis with portal hypertension |
DONG HYUN SINN; | 2022-08-01 |
| 360 | Study to Evaluate The Possible Antifibrotic Effect of Zinc Sulphate in Chronic HCV Patient Receiving Direct Acting Anti-viral Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the possible antifibrotic effect of zinc sulphate in chronic HCV patient receiving direct acting anti-viral therapy |
DINA SAMIR AHMED ATTALLA; | 2022-08-01 |
| 361 | Efficacy and Safety of Artificial Liver Support System Treatment for Immune Checkpoint Inhibitors Related Liver Failure in Patients With Hepatocellular Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the efficacy and safety of artificial liver support system treatment for immune checkpoint inhibitors related liver failure in patients with hepatocellular carcinoma. |
WENXIONG XU; | 2022-08-01 |
| 362 | Fecal Microbiome Changes Characterization and Safety Evaluation After Oral Administration of Lyophilized Capsules Containing Microbiota Suspension in Severe Alcoholic Hepatitis Patients: Double Blinded, Randomized, Placebo-Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center, randomized, parallel assignment, and double-blind placebo-controlled pilot study to characterize the intestinal microbiome in patients with severe Alcoholic Hepatitis (SAH) and evaluate the safety and the trends in improvement of diversity of intestinal microbiome following administration of lyophilized capsules containing microbiota suspension from well screened health donors. The study aims to enroll 50 patients with SAH who will be randomly assigned in 1:1 where 25 patients will be assigned to receive orally administered lyophilized PRIM-DJ2727 and Standard of Care (SOC) and the other 25 patients will be assigned to receive placebo and SOC for 4 weeks. |
PRASUN KUMAR JALAL; | 2022-07-25 |
| 363 | Evaluation of Lipid Profile in Different Grades of Non-alcoholic Fatty Liver Disease Diagnosed By Ultrasound PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Liver cells play a major role in the regulation of lipid metabolism. They are the principal location for lipoprotein and cholesterol synthesis. In healthy individuals an equilibrium is preserved between utilization, biosynthesis and transfer of lipid fractions. Many diseases that affect the parenchyma of liver can lead to changes in the structure of lipoprotein and transport through blood. Non – alcoholic fatty liver disease (NAFLD) is an abnormal accumulation of fat in the liver in the absence of secondary causes of fatty liver, such as significant alcohol use, … |
NASHWA KHALAF REFAIE; | 2022-07-20 |
| 364 | A Multicenter, Randomized, Controlled Phase IIa Study to Evaluate The Antiviral Activity and Safety of HH-003 in Nucleos(t)Ide Analogues-treated Chronic Hepatitis B Subjects With Low-Level Viremia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, controlled Phase IIa study of HH-003 to evaluate the antiviral activity and safety in nucleos(t)ide analogues-treated chronic hepatitis B subjects with low-level viremia. HH-003 is a human monoclonal antibody targeting the pre-S1 domain of the HBV large envelope protein. It blocks engagement of preS1 with sodium taurocholate co-transporting polypeptide (NTCP), the cellular receptor for HBV. |
HUAHUI HEALTH | 2022-07-20 |
| 365 | Alpha -1- Microglobulin (α1M) As An Early Biomarker in Renal Extrahepatic Manifestations of HCV-infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: find the role of alpha one microglobulin (as an early renal tubular biomarker) to identify and evaluate the prevalence of early renal manifestations among patients with chronic HCV and compared these patients with HCV-negative healthy individuals |
GHADA SAFWAT; | 2022-07-15 |
| 366 | Follow-up of People at Risk of Monkeypox Infection: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Since one month (first case confirmed the 05/06/2022), some cases of non-imported were reported by Portuguese and British authorities then in several Europeans countries, the US and the Canada. The 05/19/2022, a first case of Monkeypox was confirmed in France. The 06/01/2022, Santé Publique France (SPF) declared 33 confirmed cases of Monkeypox without a direct interaction with people returning from endemic area. No deaths are currently recorded. Currently, … |
LIEM BINH LUONG NGUYEN; | 2022-07-12 |
| 367 | Implementation of Low Cost Solutions to Help Facilitate Linkage to Care for Persons with Hepatitis C Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C Virus (HCV) infection is an ongoing challenge in the United States, with an estimated 2.4 million individuals living with HCV in 2016. According to the Virginia Department of Health, over 11,500 people were living with HCV infection in 2017 with a rate of 170 reported cases/100,000 adults. This same year, the situation was even more dire in Roanoke City which had a rate of 524/100,000 adults. Treatment with antiviral medication is curative and well tolerated. However, … |
MARIANA GOMEZ; | 2022-07-12 |
| 368 | Randomized Controlled Trial Of A Health Belief Model-Based Intervention To Prompt To Take Up The Childhood Vaccines And Effect On Vaccination Attitudes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine the effect of pregnant women aged 18 years and older who have completed their 28th week of pregnancy and received intervention based on the Health Belief Model, on encouraging childhood vaccinations and influencing their vaccination attitudes, compared to pregnant women who receive standard care group. The 12-month vaccination rate of newborns and the change in their attitudes will be determined according to the Public Attitude Towards Vaccination Scale – Health Belief Model. |
KÜBRA SULTAN DENGIZ; | 2022-07-04 |
| 369 | HIV Transmission in The Era of Scaling Up Access to Antiretroviral Therapy in Ethiopia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to understand patterns of HIV transmission in a high-prevalence area in Ethiopia, and to compare viral genetic information in people with HIV who are newly diagnosed and have not been exposed to antiretroviral therapy with persons receiving antiretroviral therapy without viral suppression. The main questions it aims to answer are: * Do people with HIV who fail to achieve viral suppression contribute to the ongoing spread of HIV in Ethiopia, … |
PER BJÖRKMAN; | 2022-07-01 |
| 370 | Development and Validation of A Machine Learning Model to Differentiate Drug-induced Liver Injury and Autoimmune Hepatitis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A retrospective, multi-center, non-interventional cohort study has been going to explore whether artificial intelligence can discriminate Drug-induced liver injury and Autoimmune hepatitis. A machine learning-based tool will be developed and validated to help clinicians to differentiate between Drug-induced liver injury and Autoimmune hepatitis |
YING SUN; | 2022-07-01 |
| 371 | Efficacy, Tolerability and Acceptability of The Single Table Regimen (STR) Biktarvy® By Trans People Living With HIV (TPLWH) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a clinical trial for TPLWH (Trans People Living with HIV) who are stable on cART with an undetectable viral load or a detectable viral load but no resistance to NRTIs and InSTI. Following written consent and screening procedures, study subjects will undergo a switch (or will restart) of their combination antiretroviral therapy (cART) to Biktarvy. The goal of this research project is to recruit an understudied population into a controlled clinical trial aimed at optimizing TPLWH cART. This will be demonstrated by measuring viral load outcomes at regular intervals, … |
CHELSEA AND WESTMINSTER NHS FOUNDATION TRUST | 2022-07-01 |
| 372 | Augmentation of Humoral Immunity Using Toll-Like Receptor (TLR) 9 Adjuvanted HBV Surface Antigen to Enhance Anti-HBSAg Response Related Papers Related Patents Related Grants Related Experts View Highlight: Unmethylated cystine-guanosine dinucleotide (CpG) motifs are pathogen-associated molecular patterns (PAMPs) associated with bacterial and viral-derived DNA that activate the innate and humoral immunity via toll-like receptor 9. This is a randomized controlled pilot study evaluating the clinical and immune correlates of a seroprotective immune response against a CpG-adjuvanted vaccine for hepatitis B. |
LYDIA TANG; | 2022-07-01 |
| 373 | A Phase 2 Open-label Trial to Evaluate Safety, Efficacy, Tolerability, and Pharmacodynamics of A Combination of JNJ-73763989, Nucleos(t)Ide Analogs, and A PD-1 Inhibitor in Chronic Hepatitis B Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate efficacy of the study intervention, based on hepatitis B surface antigen (HBsAg) levels at follow-up (FU) Week 24. |
JANSSEN RESEARCH & DEVELOPMENT | 2022-06-30 |
| 374 | Efficacy and Safety of Avatrombopag Combined With IST for The Treatment of HAAA and SAA With Abnormal Liver Function PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, single-arm clinical study. The objective was to evaluate the efficacy and safety of Avatrombopag combined with IST in very/sever aplastic anemia patients with abnormal liver function or HAAA patients treated for the first time. The design was: Patients received p-ATG for 5 consecutive days (day 1-5), at a dose of 20 mg/kg/day. Cyclosporine 3 mg/kg orally in two divided doses, with cyclosporine trough concentrations maintained at 200-250 ng/ml for 3 months to achieve maximum efficacy, and Avatrombopag, … |
INSTITUTE OF HEMATOLOGY & BLOOD DISEASES HOSPITAL | 2022-06-28 |
| 375 | A Prospective, Randomized, Blank Control, Multicenter Study to Evaluate The Efficacy and Safety of Alanine Aminotransferase（TMF）in The Treatment of Chronic Hepatitis B Patients With Normal Alanine Aminotransferase PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, open, blank controlled trial ，in order to evaluate the effectiveness and safety of Amibufenamide（TMF） in the treatment of chronic hepatitis B virus infection patients with normal ALT at week 48. |
RUIJIN HOSPITAL | 2022-06-23 |
| 376 | Characteristics of Hepatitis B HBsAg & HBsAc Carriers Simultaneously PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: HBV infection is a dynamic process with complex interactions between virus replication and the host’s immune response. The appearance of anti-HBs after HBV infection generally indicates recovery and immunity to HBV1 infection. However, there are several published studies that describe the coexistence of the marker of chronic infection (HBsAg +) and the marker of functional cure (HBsAc +). There are contradictory studies on whether the coexistence of HBsAg/HBsAc implies a different clinical course. |
MIREIA MIQUEL-PLANAS; | 2022-06-15 |
| 377 | Simplified Model of Linkage and Retention to Healthcare System, Using A Mobil Unit and A Same-day Test and Treat Approach Among Excluded Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Implementation of a model for access and retention of HIV care for vulnerable and excluded population using a mobile screening unit and a strategy of diagnosis and initiation of treatment with Bictegravir (BIC) 50 mg/ Emtricitabine (FTC) 200 mg / Tenofovir Alafenamide (TAF) 25 mg. |
FUNDACION SEIMC GESIDA | 2022-06-15 |
| 378 | Prevalence of Hepatitis B Virus Infection in Pregnancy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The most common mode of HBV transmission is materno-fetal transmission mainly during labor. This study aims to estimate the seroprevalence of HBV infection and the possible risk factors of HBV acquisition in pregnant women in Upper Egypt and to evaluate the predictive value of HBeAg and quantitative HBsAg as surrogate markers for high viremia in pregnant women. |
AMIRA MAHER; | 2022-06-15 |
| 379 | Multi-parametric Magnetic Resonance Imaging for The Precise Diagnosis and Quantitative Study of Liver Steatosis, Inflammation, and Fibrosis in Chronic Liver Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To construct a novel, non-invasive, accurate, and convenient method to achieve the degree of liver damage is an important general problem in the management of patients with chronic liver disease. The investigators would like to develop non invasive advanced Magnetic Resonance Imaging (MRI) techniques (MR elastography, MRI-PDFF) to assess the degree of liver damage in patients with chronic liver disease. These techniques could reach high diagnostic performance for detection of liver fibrosis, inflammation and liver fat content; and could decrease the number of liver biopsies, which have risks and sample only a small portion of the liver. |
YU SHI; | 2022-06-14 |
| 380 | Safety Observation of Sabin Inactivated Poliovirus Vaccine (Vero Cell) in Primary Immunization, Booster Immunization and Simultaneous Vaccination With Other Vaccines in Infants PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety of Sabin Inactivated Poliovirus Vaccine (Vero cell)(sIPV)in the primary immunization of infants at the age of 2 months and booster immunization of children at the age of 18 months, and the simultaneous immunization with other vaccines of children at the age of 2 months and older, so as to provide reference for the improvement of immunization strategy. |
SHICHENG GUO; | 2022-06-13 |
| 381 | Pharmacokinetics, Safety, Efficacy and Acceptability Study of Daclatasvir/Sofosbuvir in Children Weighing 14-35 Kilograms With Chronic Hepatitis C Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an interventional, single center, single arm clinical trial to assess the pharmacokinetics, safety, efficacy, and acceptability of daclatasvir plus sofosbuvir in treatment-naïve children weighing between 14 and 35 kg with chronic HCV GT 1-6 infection. |
MANAL HAMDY EL-SAYED; | 2022-06-05 |
| 382 | Screening for Hepatitis B, Hepatitis C and AIDS Viruses Using Dried Blood Spot PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to screen for hepatitis B, hepatitis C and AIDS viruses using a Dried Blood Spot in drug users |
GHASSAN RIACHI; | 2022-06-01 |
| 383 | Assessing The Feasibility and Preliminary Impact of A MHealth App on Reducing STI Risk in Black MSM PrEP Users PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will recruit 120 Black men who have sex with men (BMSM) from the local area, New Orleans. The main purpose of this research study is to test the effect of a new smartphone application, PCheck, on reducing the incidence of STIs, compared to routine care through the LSU-Crescent Care Sexual Health/PrEP Clinic. |
MEREDITH CLEMENT; | 2022-06-01 |
| 384 | Alterations of Gut Microbiota and Metabolites in Asian Patients With Alcohol-associated Liver Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Alcohol-associated liver disease is one of the most prevalent liver diseases worldwide, and the leading cause of liver transplantation in the U.S. Alcohol-related liver disease is associated with changes in the intestinal microbiota and metabolites. |
WUHAN UNION HOSPITAL CHINA | 2022-06-01 |
| 385 | Characteristics and Predictors of Chemotherapy-induced Liver Injury in Advanced Breast Cancer Patients Treated With Cyclin-dependent Kinase Inhibitors CDK4/6 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to evaluate the presence of predictors (single characteristics at the baseline and / or a combination of two or more parameters) useful for predicting the development of Drug-Induced liver Injury (DILI) during treatment with cyclin-dependent kinase inhibitors (CKI) with the possibility of obtaining a pre-treatment prognostic score that can assist the clinician in pre-therapy decision making. |
ANTONIO CIACCIO; | 2022-06-01 |
| 386 | Ablation of Hepatocellular Carcinoma: A Nationwide Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background Hepatocellular carcinoma (HCC) is the most common primary malignancy in the liver. Chronic infection with hepatitis C virus (HCV) is a significant risk factor and may be associated with inferior outcome. According to the Danish national guidelines, ablation should be offered patients with early HCC (tumor < 3 cm) in a cirrhotic liver, who are not transplant candidates. However, ... |
HANS-CHRISTIAN POMMERGAARD; | 2022-06-01 |
| 387 | Prevalence and Clinical Characterization of Hepatitis D Virus (HDV) Infection Among Sudanese Patients With Hepatitis B Virus (HBV), A Cross-Sectional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Sudan has a high prevalence of hepatitis B surface antigen (HBsAg), exceeding 8%. The prevalence of hepatitis B varies across different regions of Sudan, ranging from 6.8% in central Sudan to as high as 26% in southern Sudan. Hepatitis B virus (HBV) infection can lead to various complications, including cirrhosis, liver failure, and hepatocellular carcinoma (HCC). Hepatitis D virus (HDV) relies on HBV for replication and can accelerate the progression of HBV-related liver diseases, … |
NATIONAL CENTER FOR GASTROENTESTINAL AND LIVER DISEASE | 2022-06-01 |
| 388 | A Randomized, Multicenter, Double Blind, Phase II Study of Neoadjuvant Nivolumab or Placebo Plus Chemotherapy Followed By Surgery and Adjuvant Treatment in Subjects With Resectable Esophageal Squamous Cell Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Esophageal cancer, the 7th most common cancer globally, accounts for more than half a million deaths each year. The incidence of ESCC, the most common histologic type, has been stable, whereas the incidences of esophageal and gastroesophageal junction adenocarcinomas continue to increase in Western countries. Neoadjuvant chemoradiotherapy followed by surgery has become a standard of care for patients with locally advanced resectable esophageal or junctional cancer, especially in western countries. In Asia, nCT is considered as the standard of care for Stage II/III ESCC based on JCOG9204 and JCOG9907 trials. The superiority of nCRT/nCT, in terms of long-term survival, … |
SHANGHAI ZHONGSHAN HOSPITAL | 2022-06-01 |
| 389 | Efficacy of Tofacitinib in Vitiligo-a Randomized Controlled Trial in A Selected Tertiary Level Hospital in Dhaka PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Standard treatment for vitiligo often has unsatisfactory outcomes. With a new understanding of pathogenesis, novel drugs have been introduced which have shown to be effective in small-scale studies. Tofacitinib, a Janus kinase(JAK) inhibitor-2 has shown promising results in the treatment of vitiligo. However, … |
PI RESEARCH CONSULTANCY CENTER BANGLADESH | 2022-05-30 |
| 390 | Medical Practices and Representations of People From Haiti Living With or Without HIV or Chronic HBV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational, cross-sectional, qualitative study of the population of Haitian origin living in French Guiana and the professionals working with them |
CENTRE HOSPITALIER DE CAYENNE | 2022-05-30 |
| 391 | Preparing for The Final Phase of Hepatitis C Elimination in Cairns: An Implementation Trial of A Test and Treat Approach to Reach The Final 30% PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to assess the impact of models of HCV care on HCV testing, treatment uptake and cure within Cairns. Point of care testing for HCV , with test and treat strategies will be offered within a primary care service. |
MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH | 2022-05-25 |
| 392 | Safety and Tolerability Study of Redirected HBV-Specific T Cells in Patients With Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (SAFE-T-HBV) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center, single arm and open-label study to determine the safety of mRNA modified HBV-TCR redirected T-cells and to analyze the changes in tumor microenvironment caused by these HBV-TCR redirected T-cells in subjects with HBV-related HCC who are not amenable to/failed conventional treatment. |
THINESH L KRISHNAMOORTHY; | 2022-05-20 |
| 393 | Nonalcoholic Fatty Liver Disease In Persons Living With HIV Database Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions associated with fat accumulation that ranges from benign, non-progressive liver fat accumulation to severe liver injury, cirrhosis, … |
TINSAY A WORETA; | 2022-05-12 |
| 394 | Clinical Intervention Strategy for High-risk Hepatitis B Related Hepatocellular Carcinoma Based on Liquid Biopsy Screening Technique PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to explore whether there is difference in the incidence rate and incidence rate of HCC in patients with chronic hepatitis B who are screened for high risk of liver cancer. Whether the timely intervention can be used to reduce the incidence of HCC for the early screening and early warning patients can provide evidence-based medical evidence for the selection or adjustment of anti HBV drugs in high-risk patients with liver cancer. To provide evidence for whether patients with liver nodules at high risk of liver cancer need to deal with liver nodules in advance. |
ZHANG DAZHI; | 2022-05-10 |
| 395 | Exploratory Study on Antiviral Therapy for Patients With Chronic Hepatitis B Virus Infection (Immune Tolerance Period) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to demonstrate that antiviral therapy for patients with immune tolerance of CHB. On the basis of the original antiviral therapy of entecavir, further clarify the safety and effectiveness of entecavir combined with tenofovir amibufenamide.The investigators plan to enroll about 328 hepatitis B patients,. who are in the stage of immune tolerance. These participants will be devided into two groups randomly .Group A will receive the treatment of entecavir. Group B will be treated with entecavir and tenofovir amibufenamide. The participants in both groups will be followed up for 96 weeks. The primary endpoint is to compare the inhibition rate of HBV-DNA between two groups. The secondary endpoint includes: (1) Comparing the decrease of HBV DNA at 48 weeks between the two groups. (2) Comparing the HBeAg seroconversion rates at 48 weeks and 96 weeks between the two groups. (3) The changes of HBsAg at 48 weeks and 96 weeks between the two groups. (4) Comparing adverse side effects between the two groups. |
LIN BINGLIANG; | 2022-05-10 |
| 396 | The Occurrence of HCC and Possible Differences in Its Course Depending on DAA Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND It is estimated that around 71 milion people live with chronic hepatitis C virus (HCV) infection. This may lead to the development of liver cirrhosis and hepatocellular carcinoma (HCC). Liver cirrhosis is considered as one of the most common risk factors of hepatocellular carcinoma (HCC). HCC is seventh most common cancer worldwide. The treatment of HCV with direct-acting antivirals (DAAs) has led to the increase of sustained virological response (SVR) rates to more than 90%. It is suggested that the virus eradication reduces, … |
MEDICAL UNIVERSITY OF WARSAW | 2022-05-10 |
| 397 | Evaluation of The Effect of Direct-Acting Antiviral Agents on Melatonin Level in Chronic Hepatitis C Patients in Egypt PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with hepatitis c showed increased level of oxidative stress. Increased level of serum lipid peroxidation leads to the production of toxic mediators as malondialdehyde (MDA) which lead to disease progression. Chronic stress shunt tryptophan which is essential amino acid toward kynurenic pathway leading to lower level of serotonin and melatonin level. Currently, direct-acting antivirals (DAAs) show well-established efficacy against hepatitis C virus (HCV). |
HEBA MOHAMMED HASHEM ALI; | 2022-05-06 |
| 398 | Prevalence, Risk Factor and Clinical Significance of Hepatitis D Virus Infection Among Targeted High Risk Population in Thailand: Nationwide Survey 2022-2024 PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: There is very limited data of HDV in Thailand. As both HDV and HIV can accelerate the HBV course and increased the risk of death, particularly, among those with low CD4 cells/count, therefore, HDV burden in this special population is unmet need. Therefore, this study plans to perform a nationwide survey of the prevalence and predictor of HDV among people uses drugs (PWID) with and without HIV, HBV/HIV (MSM vs non MSM), HBV related cirrhosis. Findinds from this study will provide the scientific community to understand how important HDV is among HBV patients, … |
ANCHALEE AVIHINGSANON; | 2022-05-01 |
| 399 | Inhaled Interferon Α2b Treatment in Mild-to-moderate COVID-19 Infected Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In the COVID-19 pandemic era, a convenient and effective treatment for pediatric patients is unavailable. A multi-center Chinese clinical trials with the aim to using Interferon-α2b spray inhalation to develop new treatment strategies for the treatment of pediatric patients with mild or moderate type of COVID-19. The purpose of this study is to determine the safety and efficacy for Interferon α2b spray inhalation as first line treatment. |
CHILDREN’S HOSPITAL OF FUDAN UNIVERSITY | 2022-05-01 |
| 400 | Fibrin Sealant to Reduce Postoperative Bleeding After Blepharoplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is looking at the effect of Tisseel in eyelid surgery. Fibrin sealants (Tisseel) cause there to be less bleeding during surgery. Surgeons have used Tisseel for over two decades to reduce bruising. Ophthalmologists use it during surgery. Yet, there are no studies confirming the effect of Tisseel during eyelid surgery. Unpublished work suggests that it is effective in decreasing postoperative bruising. This study will confirm the effect of Tisseel on postoperative bruising in blepharoplasty. |
KARIM PUNJA; | 2022-05-01 |
| 401 | The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With Tenofovir Disoproxil Fumarate PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Nucleot(s)ide is an antiviral drug that can reduce the number of viruses, reduce the risk of HCC, regress hepatic fibrosis and reduce death from Hepatitis B viral infection. Tenofovir disoproxil fumarate (TDF) is one of nucleotide analogue that is recommended to treated patients with Hepatitis B viral infection. However, long-term TDF therapy may have side effects especially nephrotoxicity and bone toxicity. Previous studies in human immunodeficiency virus (HIV) infected patients who treated with TDF containing regimen antiretroviral therapy, … |
WATCHARASAK CHOTIYAPUTTA; | 2022-05-01 |
| 402 | A Single-center, Single-arm, Open-label, Fixed-sequence, Self-controlled Study of The Effects of HRS5091 on The Pharmacokinetics of Midazolam, S-warfarin, Omeprazole, Digoxin and Rosuvastatin in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a drug-drug interaction study conducted in healthy volunteers to evaluate the effect of HRS5091 on CYP3A4, CYP2C9, CYP2C19, P-gp, BCRP and OATP1B1, using midazolam, s-warfarin, omeprazole, digoxin and rosuvastatin as probe drugs. |
JIANGSU HENGRUI MEDICINE | 2022-04-29 |
| 403 | Australian Hepatitis and Risk Survey in Prisons PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The Australian Hepatitis and risk survey in prisons (AusHep) is a national prison-based blood-borne virus (BBV) surveillance study. This biobehavioural survey involves point-of-care testing for hepatitis C (HCV) antibodies and RNA (if antibody positive), hepatitis B surface antigens, hepatitis B surface antibodies, and HIV surface antibodies, and an interview-style survey on prior testing and treatment history and engagement in risk behaviours. The study will recruit approximately 2400 prisoner participants from 25 representative prisons across Australia, annually. |
KIRBY INSTITUTE | 2022-04-27 |
| 404 | Efficacy and Safety of Avatrombopag for Treating Thrombocytopenia in Hepatitis B Virus Related Acute-on-chronic Liver Failure Patients Receiving Artificial Liver Support System Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the efficacy and safety of avatrombopag for treating thrombocytopenia in hepatitis b virus related acute-on-chronic liver failure patients receiving artificial liver support system treatment. |
LIANG PENG; | 2022-04-27 |
| 405 | Pharmacokinetic and Bioequivalence Comparison of Baclofen and Chlorzoxazone When Administered Individually or Concurrently PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Combination treatment with baclofen and chlorzoxazone (CHZ) is under investigation for the treatment of spinocerebellar ataxia types 1 and 2. Achievement of therapeutic benefit with this combination approach requires that effective concentrations of both agents reach the systemic circulation, and ultimately reach the intended pharmacologic target. This in turn requires understanding of the clinical pharmacokinetic properties of both drugs when administered individually, as well as knowledge of the extent to which the agents might interact when given concurrently. Study Objectives: 1. To evaluate the pharmacokinetic properties of baclofen and CHZ when administered as individual entities at separate times, … |
VIKRAM SHAKKOTTAI; | 2022-04-27 |
| 406 | Immunogenicity，Safety and Cross – Immune Response With Mutant Strains of The Third Dose Using Inactivated COVID-19 Vaccine in Population Aged 18 Years and Above PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase Ⅳ follow-up clinical trial based on the previous Phase Ⅳ clinical trial of an inactivated COVID-19 vaccine (CoronaVac) manufactured by Sinovac Life Sciences Co., Ltd.The purpose of this study is to evaluate the immunogenicity,safety and cross-immune response of booster immunization using COVID-19 vaccine,to compare the similarities and differences of immune responses between primary immunization and booster immunization and to detect antibody against hepatitis A and evaluate the immune persistence of the one dose immunization schedule of hepatitis A vaccine in healthy population aged 18 years and older. |
LI ZHANG; | 2022-04-19 |
| 407 | A Randomized, Double-blind, Placebo-controlled Study to Evaluate The Pharmacokinetics, Pharmacodynamics, and Safety of Single Doses of Cetrelimab (JNJ 63723283), An Anti-PD-1 Monoclonal Antibody, in Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to characterize the pharmacokinetic (PK) profile of cetrelimab administered subcutaneous (SC) and optionally intravenous (IV) in chronic hepatitis B (CHB) participants. |
JANSSEN RESEARCH & DEVELOPMENT | 2022-04-19 |
| 408 | The Effect of Education on Oral Antiviral Use on Medication Compliance and Quality of Life in Patients With Hepatitis-B Diagnosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine the effect of the education given to patients with CHB who use oral antiviral drugs on oral antiviral drug use on drug compliance and quality of life. |
SENGUL KORKMAZ BINAY; | 2022-04-15 |
| 409 | Four-part, Randomized, Double-blind (Parts 1, 2A, 3 and 4), Multi-center, Placebo-controlled Study to Assess The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK3965193 Monotherapy in Healthy Participants and in Participants Living With Chronic Hepatitis B Infection; and GSK3965193 in Combination With Bepirovirsen in Participants Living With Chronic Hepatitis B Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase 1/2a multiple part study is a first time-in-human (FTIH) study designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of single (Part 1) and repeat doses (Part 2) of GSK3965193 in healthy participants. Part 3 will evaluate the ability of GSK3965193 to lower hepatitis B virus surface antigen (HBsAg) in participants living with chronic hepatitis B infection (PLWCHB) and will be given the option to subsequently receive treatment with open label bepirovirsen. Part 4 will evaluate the safety and tolerability of combination therapy with GSK3965193 and bepirovirsen and the potential to effect sustained virologic response in PLWCHB. |
CARLA COFFIN; | 2022-04-14 |
| 410 | Pharmacist-led Hepatitis C Diagnosis and Rapid Management – in Community PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C virus (HCV) continues to disproportionately affect vulnerable and marginalized persons in Canada. During the interferon treatment era, certain circumstances precluded individuals from receiving treatment, most notably mental health concerns or active substance use. In addition to the tolerability and efficacy of all-oral direct acting antivirals (DAAs), novel diagnostic strategies have also increased engagement in the care cascade. Point-of care and/or dried blood spot antibody as well as RNA testing allow for diagnosis without the need for phlebotomy, … |
UNIVERSITY HEALTH NETWORK TORONTO | 2022-04-13 |
| 411 | From Fungus to Virus, A Phase 1b Clinical Trial Investigating The Safety and Efficacy of Terbinafine in Chronic Hepatitis B Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Currently, there is no curative therapy available for patients that are chronically infected with the hepatitis B virus (HBV). Especially the presence of a viral reservoir of stable episomal, covalently closed circular DNA (cccDNA) in the nucleus of infected hepatocytes poses a great challenge for the development of curative therapies. HBV cccDNA acts as the template for production of viral proteins and HBV genomes. In a preclinical study, … |
ULRICH BEUERS; | 2022-04-13 |
| 412 | A Phase 2a Randomized, Double-blinded, Placebo-controlled, Multi Center, Dose Ranging Study of The Safety and Efficacy of ATI-2173 and Vebicorvir in Combination With Tenofovir Disoproxil Fumarate in Subjects With Chronic Hepatitis B Virus Infection Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blinded, placebo-controlled, multi center, dose ranging study of safety and efficacy in volunteers with chronic hepatitis B virus infection. Volunteers will be administered multiple oral doses of ATI-2173 vebicorvir in combination with tenofovir disoproxil fumarate and assessed for safety and efficacy including blood tests to show how the body metabolizes and eliminates the investigational drug as well as how the drug effects the virus infection. |
ANTIOS THERAPEUTICS | 2022-04-11 |
| 413 | Performance of Novel Simplified Score for Chronic Hepatitis B Treatment Eligibility in Thailand PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: International and national guideline for chronic hepatitis B (HBV) infection treatment recommend initiated antiviral in high HBV viral loads patients with significant liver inflammation and significant liver fibrosis. In Thailand, HBV viral loads and liver elastography are limited available in seconds to tertiary care hospital. Recently, many of simplified scoring system (TREAT-B score, WHO (World Health Organization)-simplified score and REACH-B score) were developed for assessment of antiviral initiation. This study aim to evaluate the performance of simplified score for chronic HBV treatment compare to Thailand and international standard guideline. |
WATCHARASAK CHOTIYAPUTTA; | 2022-04-10 |
| 414 | Safety, Tolerability, and Outcomes of Velpatasvir/SofosbuviR in Treatment of Chronic Hepatitis C Virus During Pregnancy (STORC) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, single arm study of Sofosbuvir/Velpatasvir (SOF/VEL) for treatment of chronic hepatitis C infection during pregnancy. Treatment will be initiated during the second or third trimester in approximately 100 pregnant people. Maternal participants will take one SOF/VEL tablet once daily for 12 weeks (84 days) and followed until 12 weeks after treatment completion (postpartum). Infants will be followed from birth until one year of age. The primary objectives are to evaluate the sustained virologic response 12 weeks after completion of SOF/VEL treatment (SVR12) in participants treated during pregnancy and to evaluate impact of antenatal treatment with SOF/VEL on the gestational age at delivery. |
CATHERINE ANNE CHAPPELL; | 2022-04-04 |
| 415 | Utility of The Use of N-acetylcysteine Associated With Conventional Treatment in Patients With Severe Acute Alcoholic Hepatitis (Maddrey> 32) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to evaluate the hypothesis that patients with severe acute alcoholic hepatitis have lower morbi-mortality if the patients receive treatment with corticosteroids + NAC, compared to patients that only receive corticosteroids. |
ANA BELÉN FERNÁNDEZ LASO; | 2022-04-01 |
| 416 | Effectiveness and Safety of Synovial Tissue and Fat Pad Stromal Vascular Fraction Bioengineering in Patients With Knee Articular Cartilage Injury, Clinical Study Phase I/II PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A phase I/II clinical trial (first in human) to assess the effectiveness and safety of the treatment of cartilage injury with a tissue engineering construct composed of stromal vascular fraction collected from the synovial membrane and infrapatellar fat of the injured knee, submitted to enzymatic processing in a single surgical time, associated with a collagen scaffold. The primary outcomes will be assessed by 3T magnetic resonance imaging, quality of life and knee function questionnaires, in addition to perioperative and post-operative complications. Secondary outcomes will be evaluated by measuring the health resources used to ensure compatibility, … |
UNIVERSITY OF SAO PAULO GENERAL HOSPITAL | 2022-04-01 |
| 417 | Fecal Microbiota Therapy in Steroid Ineligible Alcoholic Hepatitis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Alcoholic hepatitis, the most florid form of alcoholic liver disease, has a very high short-term mortality of up to 50% and no specific therapies are available other than steroids. Steroids also only show a limited utility in improving the short-term survival and boast no evidence of any long-term benefits. Additionally, only a small proportion of patients with alcoholic hepatitis are eligible to receive steroids. Thus, a large number of patients are either not eligible or do not respond to steroids and this group outnumbers those who do respond to steroids, … |
INSTITUTE OF LIVER AND BILIARY SCIENCES INDIA | 2022-04-01 |
| 418 | Relationship Between The Development of Impaired Glucose Tolerance, The Phenotype of CFLD, and The Risk of Liver Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study proposes to examine the relationship between the development of impaired glucose tolerance, the phenotype of CFLD, and risk of liver fibrosis. |
MARY C. DRINANE; | 2022-03-31 |
| 419 | A Phase 1, Open-Label, 3-Cohort, Parallel, Single Dose Study of The Safety, Tolerability, and Pharmacokinetics of A Single Oral Dose ATI-2173 50 Mg in Healthy Japanese, Chinese, and Non-Asian Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center, open-label, 3-Cohort, parallel, single-dose, study to evaluate the PK, safety, and tolerability of ATI-2173 50 mg administered orally in Japanese, Chinese, and Non-Asian healthy subjects incorporating a food effect analysis in Non-Asian healthy subjects. |
ANTIOS THERAPEUTICS | 2022-03-29 |
| 420 | Screening for The Hepatitis C Virus By TROD Paired With Mammography and Management of Chronic Hepatitis C in Women Aged 50 to 74 in The Agglomeration of Montpellier PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In France, a breast cancer screening is organized since 2004 for women aged 50-74. On the other hand, even though the seroprevalence of hepatitis C in the general French population is less than 1%, it is estimated that more than 75,000 people live with the virus without knowing it. To answer the WHO objective of eliminating hepatitis C by 2030 and in France by 2025, the investigators need to organize targeted screening. Women aged more than 50 years old, by their possible antecedents in life, … |
HÉLÈNE DONNADIEU RIGOLE; | 2022-03-23 |
| 421 | A Prospective and Retrospective Observational Study of Multidrug-Resistant Patient Outcomes With and Without Ibalizumab in A Real-World Setting: United States PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The virological efficacy of ibalizumab has been clearly demonstrated in multiple clinical trials. This study will expand ibalizumab’s clinical data set and allow a better understanding of the virologic response durability on ARV regimens with or without ibalizumab in a heterogeneous real-world patient population. Additional data on the efficacy and safety of ibalizumab and its impact on patient reported outcomes will be captured until study end. Primary Objective: To evaluate the long-term efficacy, safety, and durability of ibalizumab in combination with other ARVs by comparing the virologic, … |
PRINCY N KUMAR; | 2022-03-22 |
| 422 | A Phase 2, Single-blinded, Randomised, Controlled Multi-country Study to Evaluate The Safety, Reactogenicity, Efficacy and Immune Response Following Sequential Treatment With An Anti-sense Oligonucleotide (ASO) Against Chronic Hepatitis B (CHB) Followed By Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the safety, efficacy and immune response following the sequential treatment of GlaxoSmithKline’s (GSK) ASO compound (GSK3228836) and CHB-TI (GSK3528869A) in participants 18 to 65 years stable on NA treatment for CHB. The aim is to quantify the efficacy of sequential therapy as well as to determine an added value of sequential therapy over GSK3228836 therapy in CHB patients treated with NAs. In addition, the study will assess the effect of different treatment durations of GSK3228836 (12 or 24 weeks) prior to initiating GSK3528869A treatment. |
GLAXOSMITHKLINE | 2022-03-22 |
| 423 | A Single-center Pilot Study Evaluating A Preemptive Short Course of Glecaprevir/Pibrentasvir in Hepatitis C Positive to Negative Kidney Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to evaluate the feasibility of a 2 week course of glecaprevir/pibrentasvir (Mavyret) starting immediately prior to transplantation to treat hepatitis C virus (HCV) in kidney transplant recipients who receive a kidney from a donor with HCV. |
BONNIE LONZE; | 2022-03-20 |
| 424 | Implication of Long Non-coding RNA HOTTIP Haplotype PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatocellular carcinoma (HCC) represents the fourth common cancer and the most common cause of mortality-caused and morbidity-related cancer. Different reports implied several lncRNAs role in the progression and metastasis of HCC such as Homeobox A (HOXA) transcript at the distal tip (HOTTIP). Dysregulation of HOTTIP is associated with various malignancies including HCC, affecting survival and prognosis of cancer patients. HOTTIP promoted HCC cell proliferation/metastasis and might act as an oncogenic-lncRNA in HCC. Genetic variations such as single-nucleotide polymorphisms (SNPs), when inherited together, as a group, … |
NADIA M. HAMDY; | 2022-03-16 |
| 425 | Difference in Patterns of Liver Diseases Related Admissions in Sohag University Hospital After The Era of Direct Acting Antiviral Drugs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due to complications of cirrhosis and 1 million due to viral hepatitis and hepatocellular carcinoma Hepatitis is defined as inflammation of the liver that can result from a variety of causes such as heavy alcohol use, autoimmune, drugs, or toxins In the United States, the most common types of viral hepatitis are Hepatitis A, Hepatitis B, and Hepatitis C The other types of viral hepatitis are hepatitis D and E and are less frequently encountered Cirrhosis results from chronic liver disease, and is characterized by advanced fibrosis, … |
MOMENA HASSAN AHMED; | 2022-03-15 |
| 426 | A Prospective, Multi-Centre, Propensity Score Based Matched Pair Controlled, Study of Standard Medical Care Plus CytoSorb® 300 ML Device Compared to Standard Medical Care Alone in Patients With Acute on Chronic Liver Failure Due to Severe Alcoholic Hepatitis in Combination With Systemic Hyperinflammation and Acute on Chronic Liver Failure Score ≥2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to assess the safety and performance of the CytoSorb® therapy in patients with Acute on Chronic Liver Failure (ACLF) grade ≥ 2 due to a severe alcohol induced hepatitis (Maddrey DF > 32) and a severe inflammatory response. |
CYTOSORBENTS EUROPE | 2022-03-15 |
| 427 | Effect of Aerobic Exercise Training on Fat-fraction of The Liver in Patients With Chronic Hepatitis B and Hepatic Steatosis: A Randomised Controlled Intervention Trial. The Fit Liver Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomised, controlled, unblinded, clinical intervention trial consisting of 12 weeks of aerobic exercise training. Thirty persons with chronic hepatitis B (CHB) and hepatic steatosis are randomised to either aerobic exercise training (intervention group, n=15) or no intervention (control group, n=15). The study will investigate the effects of the exercise intervention on the liver and the hypothesis is that the exercise group will reduce the fat-fraction of the liver after the intervention. |
SOFIE JESPERSEN; | 2022-03-14 |
| 428 | Same-visit Hepatitis C Testing and Treatment to Accelerate Cure Among People Who Inject Drugs: A Cluster Randomised Control Trial (The QuickStart Study) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The QuickStart study aims to assess the impact of three models of HCV care on HCV treatment uptake and cure among people who inject drugs. Rapid point-of-care (POC) HCV testing and test-and-treat strategies will be utilised in primary health care settings across Australia. |
JOSEPH DOYLE; | 2022-03-09 |
| 429 | Leptospirosis, Tularaemia and Hepatitis E in A Rural Mountain Valley in The Alpine Region of Switzerland – A Cross-sectional Exploratory Seroprevalence Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human leptospirosis is a zoonotic disease caused by bacteria of the genus Leptospira. Due to its frequent inapparent course or mild severity with unspecific symptoms and limited availability of diagnostic laboratories the incidence of leptospirosis is likely to be underestimated. The hospital of Val Müstair is the major healthcare provider of a rural mountain valley in the canton of Graubünden/ Switzerland with approximately 1500 inhabitants. A relevant prevalence of Leptospira spp. antibodies in the population of the Val Müstair due to its geographic and social risk profile for Leptospira infection, … |
MICHAEL OSTHOFF; | 2022-03-03 |
| 430 | Impact of Dietary Assessment and Intervention on Outcomes in Liver Cirrhosis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Malnutrition and reduced muscle mass have been associated with poor outcomes in many disease conditions including severe inflammatory bowel disease, liver failure and cancers. Studies have shown that use of an amino acid supplement can specifically support muscle and nutritional health of patients with liver cirrhosis and malnutrition in general. The investigators will perform new novel non-invasive measurements of muscle mass and strength as well as inflammatory markers and record food diaries in the investigators patients with inflammatory bowel disease, … |
KAREN BOLAND; | 2022-03-02 |
| 431 | Collection of Blood to Evaluate Epigenomics and Protein Biomarkers for The Detection of Hepatocellular Carcinoma PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is the acquisition of whole blood samples and serum samples from participants with untreated Hepatocellular Carcinoma (HCC) and subjects undergoing Hepatocellular Carcinoma (HCC) surveillance. These samples will be used for research purposes to develop and validate the Helio multi-analyte blood test. |
DILPIRT BAGGA; | 2022-03-01 |
| 432 | Relationship Between Metabolic Dysfunction Associated Fatty Liver Disease and Liver Fibrosis Progression in Patients With Chronic Hepatitis B: A Multicenter Retrospective Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This multicenter retrospective study aims to study the association between the presence of MAFLD and change in liver stiffness over time in untreated and treated patients with chronic hepatitis B |
MILAN SONNEVELD; | 2022-03-01 |
| 433 | Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C virus is commona viral infection. Direct-acting antiviral (DAA) oral drugs has been used in treatment of HCVs. the effect of these drugs on male infertility is still under investigation. |
ESSAM MOHAMED EL-SAYED AKL; | 2022-03-01 |
| 434 | A Pilot, Randomized, Open-label, Single Dose Study to Evaluate The Safety and Efficacy of Celecoxib Plus Nucleos(t)Ide Analogues on The Hepatitis B Surface Antigen of Virally Suppressed Subjects With Chronic Hepatitis B(a Multicenter, Open-labelled, Randomized Controlled Trial) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the globe, about 33% (2 billion) of population has ever been infected with hepatitis B virus (HBV), and about 5% (350-400 million) were chronical HBV infection. In areas with high prevalence of hepatitis B, up to 80% of primary liver cancers are associated with HBV infection. About 25% of chronic hepatitis B virus carrier (more than 1 million people per year) eventually die of end stage liver disease associated with HBV infection, such as liver failure associated with cirrhosis and hepatocellular carcinoma. HBV replicates in the liver, … |
LAI WEI; | 2022-02-24 |
| 435 | The Study on The Immunogenicity and Persistence of Booster Dose With Hepatitis B Vaccine in College Students PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The anti-HBs produced after hepatitis B vaccination will decrease over time. College students are vaccinated with hepatitis B vaccine at birth, and their antibodies may have decreased significantly. In addition, college students are sexually active population, which has a high risk of HBV infection. It is necessary to study the anti-HBs level of college students, and analyze the strengthening immunization for this special group. This study will analyze the immunogenicity, immune persistence, and safety of booster dose of intramuscular 20 µg recombinant hepatitis B vaccines. Different booster vaccination including one-dose (0 month), two-dose (0, 1 months), or three-dose (0, 1, … |
SUPING WANG; | 2022-02-20 |
| 436 | Providing A Resource: Telemedicine at Needle Exchanges to Reach Under-served Populations – Greensboro PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to provide medication for opioid use disorder (MOUD) with buprenorphine and naloxone, or bup/nx, pre-exposure prophylaxis (PrEP) for HIV prevention, and/or hepatitis C treatment for persons who inject opioids accessing syringe services programs (SSPs), as part of a comprehensive harm reduction program, and assess the acceptability and feasibility of using telemedicine to implement the program. The initial visit will be conducted in person or remotely via telemedicine given COVID-19 protocols at the SSP site in Greensboro, North Carolina (NC); follow-up visits will be conducted via telemedicine. |
MEHRI MCKELLAR; | 2022-02-17 |
| 437 | PrEPTECH Phase 2 Study: Randomized-Controlled Trial of A Telehealth Intervention Delivering PrEP to Young Men Who Have Sex With Men and Transgender Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PrEPTECH Phase 2 is a 2-arm randomized controlled trial to assess the effectiveness of a telehealth intervention in increasing PrEP uptake among cisgender men and transgender women who have sex with men over six months. Participants (N = 400) will be randomized equally into one of two study conditions, treatment with a telehealth intervention called PrEPTECH or a control condition consisting of treatment as usual plus access to a listing of online and local PrEP resources, … |
REBECCA BRAUN; | 2022-02-12 |
| 438 | A Randomized, Prospective Study of A Behaviorally-based Tailored Disease Management Intervention Vs Control in Patients With Risk Factors for Liver Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effectiveness of a behaviorally-based tailored disease management intervention in patients with fibrosis or steatosis and risk factors for cirrhosis. |
KAREN BASEN-ENGQUIST; | 2022-02-11 |
| 439 | An Observational Study of Mother-Infant Outcomes Following Antenatal Exposure to Direct-Acting Antivirals: The Treatment in Pregnancy for Hepatitis C (TiP-HepC) Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinical interventions to reduce the risk of vertical transmission of hepatitis C virus (HCV) infection from mother to infant are highly limited. Direct-acting antiviral (DAA) medications have demonstrated excellent safety and efficacy in non-pregnant individuals, but there is a lack of data regarding the safety of these medications in pregnant women and the effectiveness of these medications in reducing mother-to-child transmission. Therefore, although HCV screening during pregnancy is now recommended in many countries, … |
JOHN WARD; | 2022-02-11 |
| 440 | Continuing Medical Education (CME) Intervention to Improve Knowledge About Viral Hepatitis B-C: A Randomized Controlled Trial Pilot at Primary-level Hospitals in Ho Chi Minh City PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of study is identifying the effectiveness of ‘continuing medical education’ (CME) to primary healthcare worker to improve knowledge about viral hepatitis B-C |
LE HONG DUC; | 2022-02-10 |
| 441 | Estimation of The Prevalence of HIV, Hepatitis C and Hepatitis B Infection Among Detainees in The Nîmes Administrative Detention Center PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: People in Administrative Detention Centers often come from areas of medium or high HIV, hepatitis C \& B endemic, and are often unaware of their serological status. Currently, HIV, hepatitis C \& B screening is not systematically performed at the CRA of Nîmes, and when performed, serological tests are used. The main disadvantage of this method is the length of time it takes to obtain the results, with subjects frequently discharged before receiving their results. To improve the care of these vulnerable persons, the aim of this study is to estimate the prevalence of HIV, … |
MÉLANIE KINNE; | 2022-02-08 |
| 442 | Utility of Abbreviated Magnetic Resonance Imaging As A Screening Tool for Hepatocellular Carcinoma in Cirrhotic Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is Utility of abbrevational magnetic resonance imaging as a screening tool for hepatocellular carcinoma in cirrhotic patients. The primary objective of the study is: • HCC detection rate of US vs AMRI in cirrhotic patients The secondary objective of the study are: – False referral rate of US vs AMRI: false referral will be defined as lack of HCC on complete MRI despite a positive US or AMRI. – … |
PANKAJ GUPTA; | 2022-02-08 |
| 443 | The Effect of Using Musical and Lighted Baby Crib Mobile on Newborns’ Pain and Stress During Blood Draw: Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is widely recognized that the use of non-pharmacological methods in neonatal pain management is low both globally and in our country. Nurses play a crucial role in managing pain through various techniques and in preventing its negative effects on newborns. Toys with sounds, lights, and different features have been found to effectively capture infants’ attention. Consequently, it is anticipated that baby crib mobiles, which combine these attention-grabbing features, could serve as effective distractions during needle interventions, potentially reducing pain and stress. However, there is a lack of research on this specific application. |
EYSAN HANZADE UMAC; | 2022-02-04 |
| 444 | A Phase II, Observer-blind, Randomized, Controlled Study to Evaluate The Immunogenicity and Safety of A Varicella Vaccine at Various Potencies Compared With Varivax, As A First Dose, Administered in Healthy Children in Their Second Year of Life PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess immune response and safety of various potencies of an investigational chickenpox vaccine given to healthy children 12 to 15 months of age. |
GLAXOSMITHKLINE | 2022-02-03 |
| 445 | Phase 2a, Randomized, Doubleblind, Placebo-controlled Trial Evaluating The Antiviral Activity, Safety and Pharmacokinetics of Repeated Oral Doses of JNJ-64281802 Against Dengue-3 Infection in A Dengue Human Challenge Model in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigational study drug, JNJ-64281802, is being developed for the prevention and treatment of dengue infection. This study is hypothesizing that the highest dose of the investigational study drug is superior to receiving a placebo with respect to its antiviral activity in healthy adult participants inoculated with Dengue Serotype 3. |
ANNA DURBIN; | 2022-02-03 |
| 446 | Acceptance of Hepatitis C Screening By Self-testing in High Risk and General Population PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of the study is to evaluate the acceptance and viability of self-testing using dried blood spot (DBS) testing assisted by center of origin or referral hospital, as a strategy for screening for hepatitis C virus (HCV) in high risk population (ex-users of drug dependence centers) compared to the general population assisted by primary care centers. |
MANUEL HERNANDEZ-GUERRA; | 2022-02-01 |
| 447 | Switching Virally Suppressed HIV-1 Infected Elderly Adults (Age ≥ 60 Years) Without Prior Confirmed Virological Failure From Current Anti-retroviral Regimen to Bictegravir, Emtricitabine and Tenofovir Alafenamide (B/F/TAF) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND: Current Kenya National Anti-retroviral (ARV) Guidelines and World Health Organization (WHO) Guidelines recommend first-line therapy of tenofovir disoproxil fumarate (TDF), lamivudine (3TC) and dolutegravir (DTG) for adult people living with HIV (PLHIV). This regimen has limitations, particularly for the aging PLHIV who are more likely to have pre-existing comorbidities and higher risk of developing comorbidities, including osteopenia, osteoporosis, and renal insufficiency. Abacavir, the preferred alternative nucleoside reverse transcriptase inhibitor (NRTI) in Kenya, is associated with increased cardiovascular risk that also limits its use in elderly populations. B/F/TAF is highly efficacious, well tolerated, co-formulated in a small pill, … |
LOICE ACHIENG; | 2022-02-01 |
| 448 | ANRS HB07 IP-Cure-B Proof of Concept (PoC) Clinical Trial. Educating The Liver Immune Environment Through TLR8 Stimulation Followed By NUC Discontinuation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The ANRS HB07 IP-cure-B study is a proof of concept Phase II clinical trial in HBeAg negative virally suppressed non-cirrhotic CHB patients. It will explore whether stopping NUC or stopping NUC after SLGN administration can increase the rate of HBsAg decline compared to standard of care CHB treatment. |
FABIEN ZOULIM; | 2022-02-01 |
| 449 | The Impact Of Choline Administration On Oxidative Stress And Clinical Outcome Of Patients With Non-Alcoholic Fatty Liver Disease NAFLD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be assessing the impact of choline supplementation in Non-alcoholic fatty liver disease patients using ultrasonography to show change in liver echogenicity, various laboratory tests as liver function, lipid profile and glucose control tests and finally on markers of oxidative stress as Thiobarbituric acid reactive substances and Leptin. |
AMAL A. ELKHOLY; | 2022-02-01 |
| 450 | Comparative Study of The Effect of Entecavir Versus Tenofovir on The Presence of HBV DNA in The Peripheral Blood Mononuclear Cells in Chronic Hepatitis B Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Liver disease associated with persistent hepatitis B virus (HBV) infection remains an important public health problem with significant morbidity and mortality. In spite of the existence of an effective vaccine, worldwide approximately 260 million people are chronic HBV surface antigen (HBsAg) carriers and current treatment with interferon and/or nucleoside analogues (NA) is not able to achieve a complete cure. The key obstacle to HBV eradication is the persistence of HBV DNA in the nuclei of infected hepatocytes, … |
ASSIUT UNIVERSITY | 2022-02-01 |
| 451 | Alterations of The Brain-Gut-Microbiome Axis Modulates Sex Differences in Outcomes of Alcohol-Related Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Significant sex differences exist in regard to alcohol use disorder (AUD) and alcoholic liver disease (ALD). To date, no studies have examined the brain-gut-microbiome (BGM) axis (which is the relationship between the gut, brain, and the bacteria within the gut) and sex-differences in AUD and ALD. Aims: 1) Demonstrate baseline sex differences in the microbiome and metatranscriptome of AUD and ALD and correlate those differences to severity, 2) determine if these baseline sex differences predicts abstinence or ALD related outcomes, … |
TIEN S. DONG; | 2022-01-31 |
| 452 | ENvarsus for Impaired Glucose Tolerance Post REnal TransplAnT Related Papers Related Patents Related Grants Related Experts View Highlight: Our hypothesis is that switching from the current standard of care twice daily Adoport (Tacrolimus) to once daily Envarsus (tacrolimus) in patients who have impaired glucose tolerance post-transplant will lead to an improvement in their glucose tolerance, and may reduce the subsequent incidence of PTDM. |
BARTS & THE LONDON NHS TRUST | 2022-01-31 |
| 453 | Immunogenicity of H. Influenzae Type B PRP-OMP Vaccines in American Indian and Alaska Native Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main goal of this study is to compare the Haemophilus influenzae type b antibody response in American Indian / Alaska Native (AI/AN) infants to two licensed vaccines: Vaxelis and PedvaxHIB. |
LAURA HAMMITT; | 2022-01-27 |
| 454 | Retrospective Study on Prolonged Sedation Effects With Inhaled Agents in Pediatric Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to evaluate the effects of halogenated gases on sedation and analgesia, to describe the tolerance and to determine the risk factors for failure, in pediatric intensive care patients during prolonged sedation. This study will be based on the medical records of patients hospitalized between 2015 and 2020. |
PIERRE-LOUIS LÉGER; | 2022-01-26 |
| 455 | Screening for Hepatitis C Using A Rapid Diagnostic Orientation Test (TROD) in Patients Over 50 Years Old in The Digestive Endoscopy Department of The Europeen Hospital Marseille PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic viral hepatitis C is a public health problem and several management recommendations are available. According to the French High Authority of Health, hepatitis C screening consists of a targeted screening of people at risk of infection by the virus, in particular drug users, people from countries with a high prevalence of the virus or who have received care in those countries, people transfused before 1992, … |
PATRICK DUKAN; | 2022-01-24 |
| 456 | Prospective, Randomized, Comparative, Non-inferiority, Multicentre Trial of Quality of Samples Obtained By Percutaneous Liver Biopsy Versus Endoscopic Ultrasound-guided Liver Biopsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Although the use of liver biopsy (LB) has decreased with the emerging non-invasive markers and techniques to evaluate liver fibrosis, histopathologic examination of liver tissue is necessary to confirm the type of liver injury. The aim of our study is to compare two methods for obtaining histological material from the liver: the percutaneous liver biopsy (PLB) and the Endoscopic ultrasound (EUS) guided liver biopsy (EUS-LB) |
J. ENRIQUE DOMÍNGUEZ-MUÑOZ; | 2022-01-19 |
| 457 | TAILOR Study: Tacrolimus Versus Mycophenolate for Autolmmune Hepatitis Patients With IncompLete Response On First Line Therapy: A Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: The combination of azathioprine and prednisone is the first-line treatment for autoimmune hepatitis (AIH), a chronic inflammatory disease of the liver. Complete biochemical remission (CR) is the first treatment goal in autoimmune hepatitis. CR is determined by AST and ALT and IgG within the reference range. CR is not reached in a substantial proportion of AIH patients: after one year 50%, … |
BART VAN HOEK; | 2022-01-19 |
| 458 | A Phase IIa Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy and Safety of Oral Antiviral Agents/hzVSF-v13 Combination Therapy Vs Oral Antiviral Monotherapy in Chronic Hepatitis B Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, parallel group, 48-week follow-up, Phase IIa clinical study. This study has been designed to evaluate the change in HBsAg (log10 IU/mL) after administration of hzVSF-v13 50 mg/dose and hzVSF-v13 200 mg/dose in combination with an oral antiviral agent (Tenofovir or entecavir, including salt-free or salt-modifying drugs) compared to an oral antiviral agent in combination with a placebo (normal saline) in patients with chronic hepatitis B who are stably receiving an oral antiviral agent (Tenofovir or entecavir, including salt-free or salt-modifying drugs) for at least 24 weeks. |
JOON HYEOK LEE; | 2022-01-11 |
| 459 | BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effect of low dose azacitidine therapy on tumor infiltrating lymphocytes (TILs) in primary tumors from patients with high-risk early stage breast cancer, paired t-tests will be first used to compare TIL count in pre- and post-treatment specimens. |
VIJAYAKRISHNA KRISHNAMURTHY GADI; | 2022-01-10 |
| 460 | A Phase II Multi-center, Randomized, Single-blind, Placebo-controlled to Evaluate Safety and Efficacy of ASC42 Tablets in Combination With Entecavir and Pegylated Interferon Α-2a in Subjects With Chronic Hepatitis B Virus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase2, randomized, single-blind, placebo controlled and multi-center study in adults with chronic hepatitis B virus. The study is aimed at evaluating efficacy and safety of ASC42 in combination with entecavir and pegylated interferon α-2a in subjects with chronic hepatitis B virus. |
ASCLETIS PHARMACEUTICALS | 2022-01-10 |
| 461 | Real World Study of Peginterferon Alpha-2b Treatment for Inactive Chronic Hepatitis B Patients: E-Cure Study PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: There are about 400 million chronic hepatitis B virus (HBV) infection patients worldwide, posing a serious threat to global public health security. In China, HBV infection occured mainly in the perinatal period or infants, and about 10% of patients in the immune tolerance stage spontaneously transit to the immune clearance stage every year and become HBeAg-negative chronic HBV infection, resulting in a significant increase in the number of inactive chronic hepatitis B (CHB) patients. In recent years, … |
ZHILIANG GAO; | 2022-01-08 |
| 462 | Well Baby, Well Family Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND: The Defense Health Agency (DHA) and the Office of Military Community and Family Policy (MC\&FP) requested assistance in evaluating the effectiveness of a military pilot implementation of a civilian program designed to assist families with infants called HealthySteps (HS; HealthySteps National Office, 2018). HS is a unique pediatric primary care-based program that helps families identify and manage parenting challenges. The program interweaves the medical support of the pediatrician’s office with the resources and services of a HS Specialist trained to help parents understand their infants’ needs (e.g., feeding, behavior, … |
JESSICA REDDING; | 2022-01-05 |
| 463 | Testing and Epidemiology of Delta Hepatitis Among Asian Americans PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Study is to 1. Understand the pattern of hepatitis delta screening among medical providers for Asian patients with chronic hepatitis B 2. Determine the proportion of Asian hepatitis B patients who have been screened and who have chronic hepatitis delta 3. Determine the pattern of hepatitis delta screening after education of medical providers on hepatitis delta |
ASIAN PACIFIC LIVER CENTER AT COALITION OF INCLUSIVE MEDICINE | 2022-01-03 |
| 464 | Gut Microbiota Analysis With Next-generation 16S RRNA Gene Sequencing in IAI Patients With Sepsis-associated Liver Dysfunction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: With the rapid development of intensive care medicine, the mortality of patients with sepsis has decreased over the past decade, but it is still the leading cause of death in intensive care unit (ICU). As an important immune and metabolic organ, the liver plays a crucial role in host defense against invading pathogens and endotoxins, as well as maintenance of metabolic and immunological homeostasis. Some studies indicate that sepsis-associated liver dysfunction (SALD) has a substantial impact on the severity and prognosis of sepsis. Intra-abdominal infections (IAI) are the second leading source of infection for sepsis after pneumonia in ICU, … |
CHINESE MEDICAL ASSOCIATION | 2022-01-03 |
| 465 | The Guidance on The Gravitationally Assisted Lactation Influences The Occurrence of Lactational Mastitis: A Clinical Cohort Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Lactation is the instinct of almost all mammals, including human beings. With the development of human society, the function of lactation has gradually deviated from nature instinct. Breastfeeding related industries, such as milk bottles, formula and breast pumps, have formed a vast consumer market, leading to a transition from breastfeeding mothers’ individual instinct to the social division of labor. Previous studies found that the incidence of lactational mastitis remains largely unchanged post World War II with some reporting an increase, … |
JIANYI LI; | 2022-01-01 |
| 466 | Evaluation of Orthohepevirus C Infection As An Emerging Cause of Zoonotic Origin Disease PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to evaluate the prevalence and the clinical impact of Orthohepevirus C infection in different human populations, and to determine its zoonotic origin comparing the sequences obtained in both human and animal populations. This is an ambispective study where Orthohepevirus C infection will be evaluated in four high risk human population: i) patients with acute hepatitis, ii) patients with positive IgM antibody against Hepatitis E virus infection with undetectable viral load, iii) HIV infected individuals, and iv) solid organ transplant recipients. Furthermore, we will analyze three animal populations: i) suburban rodents, ii) domestic rodents, … |
ANTONIO RIVERO ROMÁN; | 2022-01-01 |
| 467 | The Clinical Outcomes of Optimize Treatment of Chronic Hepatitis B Patients With Low-level Viremia Undergoing Nucleoside Treatment PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic hepatitis B seriously endangers the health of our people, especially the occurrence of HCC, which brings huge economic burden and life threat to our people. 84% – 92% of HCC in China is related to chronic HBV infection. How to further reduce the risk of liver cancer is an urgent problem to be solved in clinical research and an important direction. Although NAs treatment can make patients achieve the negative transformation of virus, it can not effectively reduce the level of virus antigen, and it also lacks the ability to improve the immune clearance of virus. As a result, … |
YAO XIE; | 2022-01-01 |
| 468 | The Clinical Outcome of Inactive HBsAg Carrier Patients With Low HBV DNA Levels and Normal ALT By Antiviral Therapy PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic hepatitis B seriously endangers the health of our people, especially the occurrence of HCC, which brings huge economic burden and life threat to our people. 84% – 92% of HCC in China is related to chronic HBV infection. How to further reduce the risk of liver cancer is an urgent problem to be solved in clinical research and an important direction. Although NAs treatment can make patients achieve the negative transformation of virus, it can not effectively reduce the level of virus antigen, and it also lacks the ability to improve the immune clearance of virus. As a result, … |
YAO XIE; | 2022-01-01 |
| 469 | The Role of Immune Semaphorins in Steatotic Liver Disease and Sepsis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The impact of the complex liver immunological network on sepsis outcome is largely unknown. Steatotic liver disease (SLD) is the most common chronic liver disease with prevalence of 25% in European countries. The question remains whether patients with SLD are more prone to bacterial infections and what is the impact of persistent liver inflammation to the systemic response to infection, sepsis course and outcomes. Semaphorins are a large family of secreted and membrane-bound biological response modifiers present in many organ systems that are associated with SLD and development of fibrosis, … |
NEVEN PAPIC; | 2022-01-01 |
| 470 | Molecular Characteristics and Prevalence of Viral Hepatitis E in Human Tissue and Cell Donors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the researchers want to focus on the prevalence of anti-HEV antibodies by a new generation test, direct detection of HEV RNA, and its genotypic analysis in a group of human tissue and cell donors. |
HANA SLEPČANOVÁ; | 2022-01-01 |
| 471 | The Use of Novel Hepatitis B Virus (HBV) Biomarkers to Detect Occult HBV Infection in Liver Donors Positive for Antibody to Hepatitis B Core Antigen (Anti-HBc) in Liver Transplantation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: After LT, long-term immunosuppressive therapy is required to prevent organ rejection. Therefore, for organs which may harbour OBI, there is a risk of reactivation which may result in liver graft failure. As a consequence, all patients who receive an anti-HBc positive graft will receive antiviral prophylaxis. Currently, all such patients will be commenced on life-long entecavir, which is highly effective in preventing reactivation.2 One major disadvantage of using such a blanket approach is that a significant proportion of anti-HBc donors may not actually have underlying occult HBV infection, … |
JAMES YAN YUE FUNG; | 2022-01-01 |
| 472 | An Experimental Study on The Effect of Tenofovir Amibufenamide on Blood Lipid During Anti-HBV Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In June 2021, Chinese Food and Drug Administration approved the launch of the self-developed new drug Tenofovir Amibufenamide(TMF). TMF is a new second generation of tenofovir(TFV) and its effect on blood lipids is unclear. Our study aims to figure out the effect of TMF on serum lipid level in the process of antiviral therapy for chronic hepatitis B patients. |
JIN YE; | 2022-01-01 |
| 473 | Disease Loads and Status of Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of study is to evaluate the current prevalence of HDV infection, and comprehensively analyze the interaction between HDV and HBV infections in the era of NAs in Taiwan. Investigators plan to set up a platform for HDV positive patients in Taiwan to invite sites or hepatologists who are interested in this field. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2022-01-01 |
| 474 | Vascular Invasion Signatures in CfDNA Support Re-staging of Small Liver Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tumor staging system based on clinicopathological charactertics has been used to guide treatment decisions. However, therapeutic outcomes of early-stage hepatocellular carcinoma (HCC) differs significantly, which strongly suggests the requirement for a re-staging of early HCC to inform treatment selection more precisely. Microvascular invasion (MVI) reflects malignant biological characteristics of early HCC, and has a potential role of guiding treatment selection. As such, … |
SHEN FENG; | 2022-01-01 |
| 475 | Assessment of The Efficacy of Lenvatinib Versus Sorafenib in The Management of Advanced Hepatocellular Carcinoma – An Open-label Randomized Clinical Control Trial in A Tertiary Care Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatocellular carcinoma is the most common type of liver cancer, which is the 3rd leading cause of cancer deaths worldwide. The incidence is expected to increase as a consequence of chronic liver disease with its multiple risk factors, including chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, excessive alcohol consumption, nonalcoholic fatty liver disease, hemochromatosis, and aflatoxin B1.It is estimated that 70%-90% of patients with HCC have chronic liver disease and cirrhosis, … |
MD. FAZAL KARIM; | 2022-01-01 |
| 476 | A Clinical and Pharmacokinetic Study of The Effectiveness of Hepatitis C Treatment (Sofosbuvir+Daclatasvir) in HIV Co-infected and Non HIV Co-infected Patients at The Level of Non-hospital Based Management in Myanmar Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatitis C is an important health problem in Myanmar affecting around 3% of the population. New drugs have been developed which have transformed the treatment of this disease around the world with very high success rates. Two of these drugs are now registered for use in Myanmar. In this study 200 patients with chronic hepatitis C(100 with HIV co-infection) will be assessed and started on the new treatment. We will observe them and measure treatment effectiveness and tolerability. In 24 patients extra blood samples will be taken for drug measurements to describe the effect of the drugs on patients in Myanmar in more detail. |
NI NI TUN; | 2022-01-01 |
| 477 | Evaluation of Novel Point of Care Hepatitis B Diagnostic Assays Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of novel point of care Hepatitis B diagnostic assays. |
GAIL MATTHEWS; | 2022-01-01 |
| 478 | An Open Label, Randomised Phase 2 Study to Evaluate The Safety and Efficacy of MTL-CEBPA Administered in Combination With Sorafenib or Sorafenib Alone in TKI Naïve Participants With Previously Treated Advanced Hepatocellular Carcinoma (HCC) and Hepatitis B or Hepatitis C Virus (OUTREACH2) Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase II study in patients with advanced liver cancer (hepatocellular carcinoma) as a result of hepatitis B and/or C infection. Participants will be dosed with either MTL-CEBPA (an experimental treatment) and sorafenib or sorafenib alone. The MTL-CEBPA is administered once every 3 weeks via intravenous infusion. Sorafenib is taken orally from Day 8 for the combination group or Day 1 for the sorafenib alone group at a dose of 400 mg twice a day. Participants will receive 3 week cycles of treatment until disease progression, unacceptable toxicity, … |
MINA ALPHA | 2022-01-01 |
| 479 | Effectiveness of Mesenchymal Stem Cell in Patients With COVID-19 Associated SARS-CoV-2, Retrospective Clinical Study: When to Apply to Which Patient? Related Papers Related Patents Related Grants Related Experts View Highlight: Mesenchymal stem cell (MSC) therapy is among the promising treatments for acute respiratory distress syndrome (ARDS). Our study aimed to investigate the clinical efficacy of MSC treatment in COVID-19 patients, to determine when this treatment can be applied to which patient, and to evaluate its contribution to prognosis. |
SEYFI KARTAL; | 2022-01-01 |
| 480 | Prospective Observational Study of Primary Sclerosing Cholangitis (PSC) in Children PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary sclerosing cholangitis (PSC) is a rare liver disease that damages the liver’s bile ducts. Bile ducts are tiny tubes that carry bile from the liver to the small intestine. Bile is a liquid produced by the liver that helps us absorb and use the nutrients in the food we eat. In people with PSC, the bile backs up into the liver and will damage it, causing scarring of the liver. The purposes of this study are to: – Collect medical and other data to learn more about PSC, how it progresses, … |
JOHN MAGEE; | 2021-12-30 |
| 481 | Hydronidone for The Treatment of Liver Fibrosis Associated With Chronic Hepatitis B:Randomized,Double-blind,Placebo-controlled,Entecavir Basic Treatment,Multicentre Phase 3 Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was a randomized, double-blind, placebo-controlled, entecavir basic treatment, multicentre clinical study. The main objective of this study was to confirm the efficacy and safety of hydronidone in the treatment of chronic hepatitis B liver fibrosis. |
LUNGEN LU; | 2021-12-30 |
| 482 | Efficacy and Safety Study of Peginterferon Alfacon-2 to Treat Chronic Hepatitis B Virus Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Current clinical practices has shown promising prospects of the therapy strategy of interferon combined with nucleos(t)ides in patients with chronic hepatitis B, but the safety and efficacy has not been fully studied. This study is aimed to exploit the safety and efficacy of the study drug, Peginterferon Alfacon-2 injection, with nucleos(t)ide (NAs), Tenofovir alafenamide Fumarate Tablets (TAF), in the patients with hepatitis B virus infection. |
JUNQI NIU; | 2021-12-28 |
| 483 | The Effects of Probiotic Against Reducing Abundance of Human Papilloma Virus (HPV) in Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of oral administration of probiotic at 9 log colony forming unit (CFU)/day to reduce vaginal abundance of HPV in women compared to placebo via the use of vaginal self-swab. |
MIN-TZE LIONG; | 2021-12-27 |
| 484 | Interest of Plasma Exchange in Patients With Anti-interferon Type 1 Autoantibodies With Severe COVID-19 – PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: COVID-19 associated mortality remains high despite the advances in therapeutics such as dexamethasone. The severity of COVID-19 results from direct viral cytotoxicity, and the inflammatory response, which is associated with a hypercoagulable state, contribute to lethal hypoxemic pneumonia. During the SARS-CoV-2 replication phase, infected cells secrete chemokines and die by activating the immune system locally. A local inflammatory loop induces tissue destruction, which activates the immune system’s circulating cells, leading to another amplifying loop called the cytokine storm. In these phenomena, … |
MAZERAUD AURÉLIEN; | 2021-12-22 |
| 485 | Saphnelo for Intravenous Infusion 300 Mg Specific Use Result Study All Patient Investigation in Patients With Systemic Lupus Erythematosus PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To collect information on and evaluate the long-term safety and effectiveness of Anifrolumab in patients with systemic lupus erythematosus in the real-world post-marketing setting. |
ASTRAZENECA | 2021-12-21 |
| 486 | Phase 3, Randomized, Open-Label, Parallel Arm Study to Evaluate The Efficacy and Safety of 180 Mcg Peginterferon Lambda-1a (Lambda) Subcutaneous Injection for 48 Weeks in Patients With Chronic Hepatitis Delta Virus (HDV) Infection (LIMT-2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Phase 3 LIMT-2 study will evaluate the safety and efficacy of Peginterferon Lambda treatment for 48 weeks with 24 weeks follow-up compared to no treatment for 12 weeks in patients chronically infected with HDV. The primary analysis will compare the proportion of patients with HDV RNA < LLOQ at the 24-week post-treatment visit in the Peginterferon Lambda treatment group vs the proportion of patients with HDV RNA < LLOQ at the Week 12 visit in the no-treatment comparator group. |
HO BAE; | 2021-12-21 |
| 487 | HBV Reactivation in Anti CD20 Treatment PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to test and describe the frequency of hepatitis B virus reactivation in patients who received anti-CD20 drugs for a wide variety of autoimmune and hemato-oncological diseases in order to find out whether a group of patients from a certain field was more sensitive to treatment in this respect than patients from other fields. |
RAWI HAZZAN; | 2021-12-16 |
| 488 | A Prospective, Multi-Centre Study (B-Sure) to Evaluate Long-Term Durability of Treatment Response in Chronic Hepatitis B Participants With and Without Nucleos(t)Ide Therapy Who Have Participated in A Previous Bepirovirsen Treatment Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a global multi-center, long-term follow-up study to assess durability of efficacy, as measured by maintenance of treatment response from the parent study, in participants who participated in a previous bepirovirsen study and achieved a complete or partial response. Eligible participants will be enrolled in this study after completing the end of study (EoS) visit in the respective parent bepirovirsen studies (studies B-Clear \[209668: NCT04449029\], B-Together \[209348: NCT04676724\], B-Fine \[212602: NCT04544956\], B-Well 1 \[202009: NCT05630807\], B-Well 2 \[219288: NCT05630820\], and TH HBV ASO-001 \[217023: NCT05276297\]). Participants will be categorized as Not-on-NA, NA-cessated, … |
ERIC CHAK; | 2021-12-14 |
| 489 | A Prospective Study for Effectiveness of 18F-FAPI PET in The Diagnosis of Liver Fibrosis: Comparison With Liver Biopsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is an open label observation clinical trial, all participants are chronic liver disease. The investigators deem to make a novel evaluate criteria to hepatic fibrosis. The point of the clinical trial is to evaluate the novel biomaker 18F-FAPI-04 by PET-CT scan in the evaluation of the hepatic fibrosis. |
THE AFFILIATED HOSPITAL OF QINGDAO UNIVERSITY | 2021-12-12 |
| 490 | Randomized Control Trial of Home-based Hepatitis C Self-testing in Key Populations in Georgia PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Self-testing with easy-to-use rapid diagnostic tests has been successfully used for diseases such as HIV. The availability of self-testing has been shown to increase testing rates and testing acceptability in diverse populations around the world, in large part due to its convenience and privacy advantages.7 Self-testing has also been effectively used to reach key populations who may not be covered by traditional healthcare programs, such as persons who inject drugs (PWID) and men who have sex with men (MSM). In Georgia, … |
KETEVAN STVILIA; | 2021-12-10 |
| 491 | A Multi-center, Open-label Study to Elucidate The Efficacy and Safety of Peginterferon Alpha-2b Therapy in The Initial Treatment of Chronic Hepatitis Patients With Normal ALT Level and Low Viremia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To date, antiviral treatment is not recommended for chronic hepatitis B patients with a normal ALT level and low viremia. The strategy is to closely monitor the patients. However, evidence suggests that these group are at risk of gradual disease progression and development of hepatocellular carcinoma. Peginterferon eliminates the hepatitis B virus through immune regulation and induction of antiviral protein expression. For patients with low viral load, the clinical cure rate is potentially promising. In this study, … |
DONGLIANG LI; | 2021-12-10 |
| 492 | Interleukin-15 Armored Glypican-3-specific Chimeric Antigen Receptor Expressing Autologous T Cells As Immunotherapy for Children With Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients may be considered if the cancer has come back, has not gone away after standard treatment or the patient cannot receive standard treatment. This research study uses special immune system cells called AGAR T cells, a new experimental treatment. The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancers. This research study combines two different ways of fighting cancer: antibodies and T cells. Antibodies are types of proteins that protect the body from infectious diseases and possibly cancer. T cells, also called T lymphocytes, … |
ANDRAS HECZEY; | 2021-12-08 |
| 493 | A Phase 1b, Open-label, Single-arm, Multicenter Study to Assess Efficacy, Safety, and Tolerability of Treatment With JNJ-73763989, JNJ-64300535, and Nucleos(t)Ide Analogs in Virologically Suppressed, HBeAg-negative Participants With Chronic Hepatitis B Virus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of the study intervention based on hepatitis B surface antigen (HBsAg) levels. |
JANSSEN RESEARCH & DEVELOPMENT | 2021-12-06 |
| 494 | Cumulative Pregnancy Rate With Lower and Higher Dose of Gonadotropin During Controlled Ovarian Hyperstimulation During IVF Among Expected Poor Responders: A Prospective, Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Controlled ovarian hyperstimulation (COH) is an important step during in vitro fertilization (IVF). Its aim optimally is to recruit 10-15 oocytes. When deciding on the actual treatment, different stimulation protocols, various stimulating agents and wide range of gonadotropin dose can one choose from. Prior to the decision on the actual stimulation protocol and gonadotropin (Gn) dose the patient’s expected response to stimulation is assessed primarily using ovarian reserve markers. Most medications used during stimulation exert their effect in a dose-dependent manner hence with a higher Gn dose one would expect a better response, … |
PETER KOVACS; | 2021-12-02 |
| 495 | Shandong Provincial Integrated Traditional Chinese and Clinical Medicine(Chronic Hepatitis B and Its Complication) Prevention and Treatment Project PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hepatic encephalopathy is the most common complication after TIPS, and hepatic encephalopathy occurs in almost all portosystemic shunts. For patients with severe upper gastrointestinal bleeding or refractory ascites in the decompensated chronic hepatitis B, transjugular intrahepatic portosystemic shunt (TIPS) is a very effective treatment. However, due to the severe complications such as hepatic encephalopathy after TIPS, the clinical application of TIPS is limited. Literature studies have shown that the incidence of encephalopathy after TIPS is about 35%. TIPS reduces the portal vena blood flow into the liver by establishing a new channel. But at the same time, … |
LILI CAO; | 2021-12-01 |
| 496 | A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Proof-of-Concept, Phase 2a Study to Evaluate The Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Intravenous TAK-242 in Subjects With Acute Alcoholic Hepatitis Causing Decompensation of Alcohol-related Cirrhosis and Acute-on-Chronic Liver Failure PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A phase 2a double-blind, randomized, placebo-controlled, multicenter, proof-of-concept study to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of TAK-242 in subjects with acute decompensation of alcohol-related cirrhosis due to alcoholic hepatitis resulting in acute-on-chronic liver failure. |
AKAZA BIOSCIENCE | 2021-12-01 |
| 497 | Asia-Pacific Multi-Centre Randomized Trial of Laparoscopic Versus Open Major Hepatectomy for Hepatocellular Carcinoma (AP-LAPO Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Hepatocellular carcinoma (HCC) is the sixth most common malignancy in the world. Major hepatectomy (resection of > 3 liver segments) is needed if tumor is close to major blood vessels within liver. Despite low mortality, open major hepatectomy (OMH) is associated with high tumor recurrence rate, and short survival. Immunosuppression due to surgical stress and blood transfusion, and dissemination of tumor cells because of tumor manipulation all contribute to tumor recurrence. Laparoscopic major hepatectomy (LMH) is a newly developed minimally invasive technique for HCC. Apart from less wound problems and shorter recovery time than open surgery, … |
KELVIN K.C. NG; | 2021-12-01 |
| 498 | A Phase Ib, Open Label Study to Assess The Safety and Efficacy of Sequential Administration of P1101 and Anti-PD1 in Interferon-Naive Adults With Chronic Hepatitis B or D Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary objective: To evaluate the safety and tolerability of sequential administration of P1101 and anti-PD1 in patient with chronic hepatitis B or D infection Secondary objectives: 1. To explore HBsAg loss and kinetics during the study period 2. To assess the anti-viral effect during the study period 3. To evaluate the rate of ALT normalization |
PHARMAESSENTIA | 2021-12-01 |
| 499 | Cluster Randomized Controlled Study of Home-based Hepatitis C Self-testing in Karachi, Pakistan PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: To achieve the goal of elimination of hepatitis C infection in Pakistan, the strategy of elimination needs to be increasingly directed towards case finding through mass screening in rural or peri-urban communities to identify and treat those not yet aware of their infection. Self-testing (ST) with easy-to-use rapid diagnostic tests has been successfully used for diseases such as HIV. The availability of self-testing has been shown to increase testing rates and testing acceptability in diverse populations around the world, … |
SAEED HAMID; | 2021-11-29 |
| 500 | Prevention of HCC Using Mobile Phone Applications: A Disease Management Project Based on CR-HepB Platform PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective cohort study is initiated to evaluate the compliance improvement to the standardized follow-up and clinical management in the population of compensatory hepatitis B cirrhosis with a mobile health application (APP). Patients were enrolled and divided into APP self-management group (APP only ) and APP intelligent-management group (APP and online interaction). The compliance to the standardized follow-up and clinical management (every six months) under the two clinical management modes would be evaluated and compared with the history data extracted from the platform of China Registry of Hepatitis B (CR-Hep B). |
JIDONG JIA; | 2021-11-15 |