Clinical Digest: Recent Clinical Trials on Meningitis
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Meningitis. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Meningitis
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Bacteriological Profile and Antibiotic Sensitivity in Neonatal Intensive Care Unit At Assuit University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to assess the bacteriological profile and antibiotic sensitivity in NICU of pediatric hospital of assuit university. |
MADLEEN THABET HOFNI BASALI; | 2025-05-01 |
| 2 | Risk Factors , Types and Neuroimaging Findings in Patients With Cerebral Palsy at Assiut University Children’s Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral palsy (CP) is the most common motor disorder among children as its worldwide prevalence is ranging from 1.5 to more than 4 per 1000 live births or children of a defined age range. * Pediatric cerebral palsy is a clinical syndrome caused by brain injury or lesions in children from before birth to 1 month after birth, and mainly manifests as non progressive central dyskinesia and abnormal posture. * Research has shown that the prevalence of cerebral palsy in children worldwide is about 3.16% , … |
ASSIUT UNIVERSITY | 2025-05-01 |
| 3 | Ultra-early Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: Feasibility and Potential Benefit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the feasibility and potential benefit of Gamma Knife stereotactic radiosurgery (GK-SRS) as an ultra-early treatment option for trigeminal neuralgia (TN). The main questions it aims to answer are: 1. will earlier GK-SRS provide more durable pain relief compared to later GK-SRS? 2. will earlier GK-SRS reduce or eliminate the need for high-dose medical therapy? 3. will earlier GK-SRS have a lower risk of serious complications compared to other first-line treatments? If participants are assigned to GK-SRS treatment group, they will be asked to: • Undergo a preoperative MRI, … |
TEJAS SANKAR; | 2025-05-01 |
| 4 | Platform Trial For Cryptococcal Meningitis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Cryptococcal meningitis is a fungal infection that causes a severe syndrome of meningitis that is 100% fatal without antifungal therapy. Even with antifungal therapy, mortality rates remain high, especially in low and middle income countries where the ongoing HIV/AIDS pandemic increases the risk of cryptococcosis among persons living with HIV infection. The combination of amphotericin and flucytosine (5-FC) has been the mainstay of therapy for the initial management of cryptococcal meningitis for 4 decades. Indeed, the effective delivery of these first line therapy in Africa can lower mortality to 25%. However, several challenges exist. First, … |
DAVID R BOULWARE; | 2025-04-21 |
| 5 | Seven Day Versus Fourteen-day Corticosteroid in Patients With Severe Alcohol -Associated Hepatitis- A Double Blind Randomized Controlled Trail (STASH II) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Alcohol-associated hepatitis (AAH) is one of the most severe manifestations of the spectrum of alcohol related liver disease (ARLD), with high morbidity and mortality. Currently, corticosteroids are the standard of care for patients with severe AAH, but no consensus exists on the dosing schedule of steroids. The investigators have recently demonstrated that tapering prednisolone over 4 weeks reduces the risk of infections at day 90. However, the investigators wanted to test whether the reduction in the duration of therapy would provide a similar benefit as tapering the dose of prednisolone. Therefore, … |
ANAND KULKARNI; | 2025-04-07 |
| 6 | Comprehensive Outcomes Monitoring for Peri- and Postnatal Invasive Group B Strep Sequelae (COMPPASS) Registry PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this registry is to collect and store important medical and non-health information on children from 0 to 18 years of age affected by early- (up to 24 hours after birth) and late-onset (up to 90 days after birth) invasive Group B Streptococcus (iGBS) and their families. Data collected from families of children affected by perinatal iGBS will support further research to understand the short- … |
DONNA RUSSELL; | 2025-04-01 |
| 7 | Limited Versus Extended Trophic Feeding (LET-FEED) Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study Hypothesis/Question In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis (LOS) without increasing the risk of other adverse outcomes. Study Design Type This is a multi-center, open-label, parallel-group, individual randomized controlled trial comparing two different trophic feeding regimens in preterm infants born between 25w0d and 31w6d. These infants will be randomly assigned to either the intervention group, receiving limited trophic feeding (20 to 25 mL/kg/day for one day) or the control group, … |
GREGORY C. VALENTINE; | 2025-04-01 |
| 8 | A Follow-up Trial to Assess The Persistence of The Immune Response to The Group B Streptococcus Vaccine (GBS-NN/NN2) After A Primary Vaccination of Healthy Pregnant Women, and to Assess Safety, Reactogenicity, and Immunogenicity of The GBS-NN/NN2 Vaccine When Administered During Follow-Up As A 1 Booster Dose During A New Pregnancy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to evaluate the persistence of the immunoglobulin G (IgG) antibody responses, specific to Alpha-like protein CN (AlpCN), Ribosomal Protein N (RibN), Alpha-like protein 1N (Alp1N), and Alpha-like protein 2 and 3 (Alp2-3N), after a primary vaccination with GBS-NN/NN2 in all participants. |
MINERVAX APS | 2025-03-07 |
| 9 | A Phase I/II Clinical Study of An Intrathecal Combination of PD-1/CTLA-4 Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis from Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Leptomeningeal metastasis, characterized by tumor cells infiltrating and proliferating in the subarachnoid space, represents a distinct pattern of central nervous system involvement and is a fatal complication of malignant tumors. This study is a prospective, single-arm phase I/II clinical trial aimed at evaluating the safety and efficacy of intrathecal Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) bispecific antibodies combined with pemetrexed in treating leptomeningeal metastases from solid tumors, with the goal of identifying more effective treatment options. |
ZHENYU PAN; | 2025-03-07 |
| 10 | Nursing Strategies to Increase Vaccination Rates in Adolescents: Education, Video Animation and Games PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose: This study aims to evaluate how immunization education, video animation, and game interventions based on the Health Belief Model (HBM) affect the immunization decisions of late adolescents. The findings could contribute to the development of targeted interventions to increase vaccine acceptance among adolescents. Hypotheses: Does the educational intervention, video animation, and game application affect adolescents’ knowledge of vaccines? Do these interventions influence adolescents’ positive attitudes towards vaccines? Will the interventions lead to significant changes in adolescents’ health beliefs, especially regarding perceived risks, benefits, … |
HAKAN AVAN; | 2025-03-03 |
| 11 | An Observational, Prospective and Retrospective Clinical Study to Evaluate The Performance of QIAstat-Dx® Meningitis/Encephalitis (ME) Panel Plus During Normal Conditions of Use PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Performance evaluation of QIAstat-Dx® ME Panel Plus using the QIAstat-Dx® Analyzer to demonstrate that the QIAstat-Dx® ME Panel Plus achieves its intended performance during normal conditions of use by the intended user in the intended environment |
SARAH JOHNSON; | 2025-03-01 |
| 12 | Molecular Epidemiology of Enteroviruses Detected at The Virology Laboratory of Brest University Hospital During The Period 2018-2024: Retrospective Analysis of An Atypical Meningitis Epidemic in 2024 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to learn more about enterovirus infections detected in the cerebrospinal fluid of patients at CHU de Brest. Researchers will analyze medical records and laboratory data collected between 2018 and 2024. They will look at how these infections present in patients, and whether a specific virus type, called Echo-9, may be associated with different clinical features or represent an emerging variant. |
UNIVERSITY HOSPITAL BREST | 2025-03-01 |
| 13 | Neonatal Comfort Seat Allowing Safe Lumbar Puncture and Minimizing Failure: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A research trial which compares standard of care against employing a novel device for immobilization of babies undergoing upright LP, the present working name for the device is LP Comfort Seat (LPCS). The research question is: P: In late-preterm to term babies who are 0-28 days and undergoing LP for R/O Sepsis I: Is the LPCS more effective C: Than human/RN assisted upright positioning O: In generating a higher rate of first attempt LP success Primary outcome measure is first attempt LP success (any evidence of CSF which is diagnostically useful by content and volume) Secondary outcome measures could include 1. A qualitatively unadulterated tap (no blood) although as you know this is hard to control even with perfect positioning and technique and single pass 2. A difference in FLACC score as measure of overall pain/comfort between test and control |
JOEL COX; | 2025-03-01 |
| 14 | Post-marketing Database Survey: A Cohort Study to Evaluate The Safety of Cuvitru in Patients with Primary Immunodeficiency Using The PIDJ2 (Primary Immunodeficiency Database in Japan) Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a retrospective database study in Japan to evaluate the safety of Immune Globulin Subcutaneous (Human), 20% Solution in participants with primary immunodeficiency disease (PID). This survey will conduct in use of medical database called PIDJ2. |
TAKEDA | 2025-02-17 |
| 15 | A Phase I, Multicentre, Open-label, First-in-Human, Dose Escalation and Expansion Study of DM002 in Patients With Advanced Solid Tumors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of study： The study has two parts: Part 1 Dose Escalation and Part 2 Dose Expansion. In Part 1, a few participants will receive the lowest dose of study drug. The study team will make sure it is safe and tolerated before enrolling new participants at a higher dose of study drug. There will be up to six or more dose levels of study drug tested (called cohorts). Which dose you receive will depend on how many participants have taken part in the study before you. The purpose of Part 1 of the study is to evaluate the safety of the study drug at different dose levels, to understand what your body does to the study drug, and to find the best dose of study drug in people who have advanced solid tumor cancers. In Part 2, participants will receive the best dose level that was determined in Part 1 of the study. The purpose of Part 2 of the study is to evaluate the safety of the study drug at the dose level determined in Part 1, to understand what your body does to the study drug, and to see how your cancer responds to the study drug. Participants will: Participants will have 17 or more visits to the study centre. This study has a screening phase of up to 28 days , and a treatment phase with cycles of 21 days each. Participants will also have an End of Treatment (EOT) visit 21 days after the final study drug treatment, and a Follow-up visit 30 days after the EOT visit . Participants will be contacted by telephone every 3 months after the Follow-up visit to check on the wellbeing and record any new anticancer therapy they may have started. |
XADCERA BIOPHARMACEUTICAL SUZHOU | 2025-02-17 |
| 16 | A Cluster-randomised, Open-label Trial to Compare The Impact of Combined Mass Vaccine and Drug Administrations, Mass Drug Administration, Mass Vaccinations, or No Intervention on Plasmodium Falciparum Malaria Transmission PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open i.e. not blinded, cluster-randomised, controlled intervention study. The study will use a factorial design to estimate the protective effectiveness of mass drug administrations, mass vaccinations, combined mass vaccinations and drug administrations versus the current standard of care. |
LORENZ VON SEIDLEIN; | 2025-02-15 |
| 17 | Parental Stress and Attachment in Premature Infants in Their First Months of Life in Early Months of Life in Child Development and Early Care Centres PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term. Furthermore, previous studies have linked prematurity, as an associated risk factor, with possible alterations in the bonding between the child and his or her mother in the first years of life. The possible impact that the stay in the neonatal unit may have on the mental health of the parents is noted. In fact, … |
JOSE MIGUEL SORIA LOPEZ; | 2025-02-01 |
| 18 | Prospective Ocular Imaging for Intracranial Pressure Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospectively recruiting, database development study collecting images and videos of the spontaneous venous pulsation at the back of people’s eyes – this is a pulse one can see on examination of the back of the eye, originating from the blood vessels around the nerve that connects the eye to the brain (the optic nerve), and is present in most people who have normal pressure around the brain. However, in people with raised pressure in the brain, this pulse disappears as the pressure rises. Many things can cause the pressure around the brain to increase, including tumours, … |
KING’S COLLEGE HOSPITAL NHS TRUST | 2025-01-10 |
| 19 | A Randomized, Blinded, Peer-controlled Clinical Trial to Evaluate The Safety and Immunogenicity of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 7-17 Year Olds PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, blinded, peer-controlled study. There will be 2 treatment groups, screened subjects were given study numbers in the order of enrollment and randomly assigned to the test and control groups in a 1:1 ratio. Subjects were required to complete a 1-dose immunization program with 0.5 ml of vaccine in both the test and control groups, afterwards some subjects entered the immune persistence group. |
ZHIQIANG XIE; | 2024-12-14 |
| 20 | A Phase I, Multicenter, Open-label, First-in-Human, Dose Escalation and Expansion Study of DM001 in Patients With Advanced Solid Tumors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to find out about the safety, efficacy, and tolerability of DM001 for patients with the advanced solid tumors. DM001 is an experimental drug which is not approved by health authorities for the treatment of advanced solid tumors. Participants will have up to 17 visits during the study.There will be up to a 4-week Screening Period followed by a treatment period that will be divided into 3-week cycles/ Participants will have 5 study visits during Cycle 1, 3 visits during Cycles 2 and 3, … |
XADCERA BIOPHARMACEUTICAL SUZHOU | 2024-10-24 |
| 21 | NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Blood Flow in Infants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates. For many years, the ultrasound group in Trondheim has been at the forefront in the development of new ultrasound technology for the diagnosis and monitoring of disease. Several methods previously developed in this research group are today widely used in hospitals around the world. In this project the investigators aim to test a new ultrasound technology that allows continuous monitoring of cerebral blood flow in sick neonates and pre-term children. This technology was CE-certified in October 2022, … |
SIRI ANN NYRNES; | 2024-10-20 |
| 22 | An Open-label Extension Study to Evaluate Rozanolixizumab in Pediatric Study Participants With Generalized Myasthenia Gravis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess the long term safety and tolerability of additional 6-week treatment cycles with rozanolixizumab in pediatric participants with generalized Myasthenia Gravis (gMG) aged ≥2 at the time of the Screening Visit of MG0006. |
UCB BIOPHARMA SRL | 2024-10-08 |
| 23 | A Phase 1, First-in-human, Open-label Study to Evaluate The Safety, Tolerability, PK, and Preliminary Anti-tumor Activity of The Novel Oral CDK2 Degrader NKT3964 in Adults With Advanced/Metastatic Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the Dose Escalation phase of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity to determine the preliminary recommended dose for expansion (RDE) of NKT3964 in adults with advanced or metastatic solid tumors. The goal of the Expansion phase of the study is to evaluate the preliminary anti-tumor activity of NKT3964 at the RDEs based on objective response rate (ORR) and determine the preliminary recommended Phase 2 dose (RP2D). |
NIKANG THERAPEUTICS | 2024-09-19 |
| 24 | Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With Subarachnoid Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs) in patients who have had spontaneous subarachnoid hemorrhage (SAH). Patients with SAH were chosen as the target population because they frequently require prolonged admission to the intensive care unit and drainage of CSF in order to prevent hydrocephalus. The estimated sample size is 20 subjects. This is a prospective cohort of patients with SAH. Patients will be included if they have a spontaneous SAH, aged 18-65 years old, … |
AARON COOK; | 2024-07-02 |
| 25 | Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors： A Phase I/II Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label, single-arm, phase I/II trial of immune checkpoint inhibitor combined with pemetrexed intrathecal injection for leptomeningeal metastasis from solid tumors, to evaluate the safety and efficacy. |
ZHENYU PAN; | 2024-06-30 |
| 26 | Effect of Music Therapy Applied During Lumbar Puncture on Infants’ Pain Perception: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacterial meningitis is a serious infection that is more common in newborns is associated with significant morbidity and mortality. The gold standard for the diagnosis of bacterial meningitis is a positive cerebrospinal fluid (CSF) culture, usually obtained via lumbar puncture (LP). İnfants and children have similar physiological responses to pain as adults has led to greater emphasis on the assessment and management of pain in children. Therefore, … |
AYŞE METIN; | 2024-06-15 |
| 27 | Phase IV Clinical Study of The Safety of Menhycia® in 3-Month-Old Infants PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an open, multicenter Phase IV clinical study to evaluate the safety of vaccination with Menhycia®. The study plan is to enroll approximately 3,000 infants at 3 months of age who have not been vaccinated with any epidemic encephalitis vaccine, and to administer a total of 3 doses of Menhycia®, with a minimum of 1 month between doses, and a booster dose of 1 dose of immunization is allowed at 12 months of age. |
CANSINO BIOLOGICS | 2024-06-01 |
| 28 | Infectious Complications Associated With The Use of Peri-partum Neuraxial Anaesthesia in Patients With Primary Immunodeficiencies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate if neuraxial anesthesia (epidural or intradural anesthesia) used during childbirth is associated with more frequent infectious complications in patients with primary immunodeficiencies (PID). |
CAROLINE CHARLIER-WOERTHER; | 2024-06-01 |
| 29 | A Phase I Randomized, Observer-blind, Placebo-controlled Trial of A Haemophilus Influenzae Serotype A (Hia) Glycoconjugate Vaccine With Alum Adjuvant in Young Adults 18 to 40 Years of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Haemophilus influenzae serotype a (Hia) has emerged as a leading cause of serious illness in Indigenous children in Canada and Alaska in recent decades. In hospital-based surveillance studies, Hia was the most common cause of invasive disease, resulting in morbidity or mortality after Haemophilus influenzae serotype b (Hib). Given the success of the Hib vaccine program and the pathophysiologic similarities between Hib and Hia, immunization is the obvious way to protect Indigenous children living in small and scattered communities. The Public Health Agency of Canada has been working with the National Research Council and other members of the Consortium, … |
BRIAN WARD; | 2024-05-29 |
| 30 | Multiparametric Molecular Panel Evaluation QIAstatDxMeningitis/Encephalitis for Diagnosis of Infections of The Central Nervosous System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Infections involving the central nervous system (CNS), such as meningitis/encephalitis (ME), are serious clinical conditions associated with high morbidity and mortality rates, as well as significant long-term consequences. ME can be caused by a wide variety of pathogenic agents. Clinical symptoms may vary and it has been shown that early identification of the pathogens causing ME allows for timely and appropriate treatment, thus reducing permanent neurological damage. The multiparameter panel QIAstat-Dx®Meningitis/Encephalitis can detect in one hour on a sample of 15 bacterial, viral and fungal pathogens. In the diagnostic routine, … |
LILIANA GABRIELLI; | 2024-04-17 |
| 31 | Optimizing The Dose of Flucytosine for The Treatment of Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cryptococcal meningitis (CM) is a fungal infection that causes a severe syndrome of meningitis that is 100% fatal without antifungal therapy. Even with antifungal therapy, mortality rates remain high, especially in Africa where the ongoing HIV/AIDS pandemic leads to higher prevalence of cryptococcosis. Combination of amphotericin and flucytosine (5-FC) is the mainstay of therapy for the initial management of CM. Indeed, … |
DAVID B MEYA; | 2024-04-09 |
| 32 | A Multicenter, Randomized, Double-blinded, Positive-controlled Phase Ⅲ Clinical Trial to Evaluate Lot-to-lot Consistency, Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blinded, positive controlled study to evaluate the lot-to-lot consistency, immunogenicity and safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in adults aged 18 to 55 years. Subjects will be randomized to receive investigational Lot 1, Lot 2, Lot 3 vaccine or control vaccine in a 1:1:1:1 ratio, with the subjects in experimental group randomly and equally assigned to three different batches of MCV4 for single-dose vaccination. |
ISTI SUHARJANTI; | 2024-03-20 |
| 33 | Comparative Study Between Dexmedetomidine and Fentanyl As Adjuvants to Bupivacaine in Femero Sciatic Block for Below Knee Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post dural puncture headache, hematoma, and neurological deficit |
AIN SHAMS UNIVERSITY | 2024-03-11 |
| 34 | A Randomized, Blinded, Peer-controlled Clinical Trial to Evaluate The Safety and Immunogenicity of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in A Population Aged 18-59 Years PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, observer-blind, peer-controlled study. There will be 2 treatment groups, screened subjects were given study numbers in the order of enrollment and randomly assigned to the test and control groups in a 1:1 ratio. Subjects were required to complete a 1-dose immunization program with 0.5 ml of vaccine in both the test and control groups. |
QING WANG; | 2024-03-01 |
| 35 | Factors Influencing The Mortality of Patients With Subarachnoid Haemorrhage in The Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Spontaneous subarachnoid haemorrhage (SAH) is a serious cerebrovascular disease with high morbidity and mortality.Determining the factors associated with mortality in the ICU follow-up and treatment of patients with spontaneous SAH is very important for clarifying these uncertainties and improving ICU outcomes.In the literature, there are very few studies analysing ICU mortality and mortality-related factors in this patient group.The aim of this study was to determine the demographic/clinical characteristics and factors affecting the mortality of spontaneous SAH patients admitted in the ICU. |
MELIKE CENGIZ; | 2024-03-01 |
| 36 | Drainage Fluid Biomarkers and Postoperative Gastrointestinal Dysfunction in Colorectal Surgery. A Monocentric Prospective Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Postoperative gastrointestinal dysfunction (POGD), often referred to as postoperative ileus (POI) after colorectal surgery, is characterized by symptoms such as nausea, vomiting, abdominal distension, and delayed bowel movements. The incidence of this issue varies among medical institutions, impacting patient nutrition, prolonging hospital stays, and increasing healthcare costs. The complex pathogenesis of POGD involves a brief neurogenic phase (within 3 hours) and a more prolonged inflammatory phase (beginning at 3-4 hours and lasting for days). The inflammatory phase is crucial and is recognized as initiated by mast cells and damage-associated molecular patterns that activate macrophages in the intestinal muscle layer. Subsequently, … |
CHAOYANG HOSPITAL OF CHINA MEDICAL UNIVERSITY | 2024-02-21 |
| 37 | Evaluation of Herpes Zoster Characteristics and Costs in Cancer Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale. Cancer patients are more likely to develop herpes zoster (HZ) and its complications. An acute episode of HZ implies in postponement of current cancer treatments, hospitalization, high risk of development of postherpetic neuralgia and high costs for paying sources. A better understanding of disease incidence, hospitalization, development of postherpetic neuralgia, and costs generated for funding sources may increase awareness of the impact of vaccination on oncology population. Objectives. Obtain HZ incidence and percentage of hospitalization in study population according to cancer type, topography, … |
AC CAMARGO CANCER CENTER | 2024-02-15 |
| 38 | Phase II Clinical Study of Contezolid for The Treatment of Tuberculous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Contezolid is a novel oxazolidinone antibiotic developed by Shanghai Mengke Pharmaceutical Co., Ltd., which successfully went public in 2021. It inhibits bacterial growth by interfering with protein synthesis through its translational inhibitory effect on bacteria. Contezolid has demonstrated promising clinical results in patients with drug-resistant tuberculosis, making it a powerful tool in the fight against drug-resistant tuberculosis. Currently, there is a lack of pharmacokinetic data on contezolid in patients with central nervous system tuberculosis. Some studies have reported the steady-state concentrations of contezolid in the serum and cerebrospinal fluid (CSF) of tuberculous meningitis patients receiving multidrug therapy, … |
NIE WENJUAN; | 2024-02-01 |
| 39 | The Efficacy of High-frequency Short-time Spinal Cord Stimulation in The Treatment of Herpes Zoster-associated Neuralgia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Zoster-associated neuralgia (ZAN) is a type of neuropathic pain caused by the reactivation of the varicella-zoster virus (VZV). The global annual incidence is approximately 3-5 per 1,000 individuals, and in China, the incidence is around 4.89 per 1,000 individuals, increasing with age. The underlying mechanisms of ZAN involve neuroinflammation, peripheral and central sensitization, and other factors, ultimately leading to anxiety, depression, and significant reductions in quality of life. Treating ZAN remains challenging. Spinal cord stimulation (SCS) alleviates pain via multiple mechanisms, including the gate control theory, modulation of neurotransmitters (e.g., gamma-aminobutyric acid), suppression of neuroinflammation (e.g., … |
LI ZHAO; | 2024-02-01 |
| 40 | The Effect of The Anticholinergic Burden on Complications and Mortality Following Elective Coronary Artery Surgery in Patients Over 60 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Many drugs have anticholinergic activity. This means that it blocks the muscarinic binding of the neurotransmitter acetylcholine. In this study, the anticholinergic burden of the patients in the perioperative period will be calculated with the Anticholinergic Cognitive Burden Scale (ACBS) and patients with a score of 1 or above will be included in the study. Anticholinergic load of drugs used in the intraoperative period; Its effect on postoperative hospital stay, morbidity and mortality following elective heart surgery will be investigated. |
MUHAMMED ÇOBAS; | 2024-01-01 |
| 41 | The Effect of Use of Infection Control Precaution Package on The Rate of SSI in Patients Undergoing Craniotomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Surgical site infections (SSI) are the most common complications after surgical operations and are in the top three in Healthcare Associated Infections (HIE). Due to surgical site infections, morbidity, mortality and hospital stay in postoperative patients increase, as well as the cost of treatment. The World Health Organization (WHO) has published a list of infection control measures, including preoperative, intraoperative and postoperative precautions, … |
BIRGÜL BELGIN; | 2024-01-01 |
| 42 | A Phase II, Randomized, Open-Label Trial of A Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus A Standard Nine-Month Regimen for The Treatment of Adults and Adolescents With Tuberculous Meningitis: Improved Management With Antimicrobial AGents Isoniazid RifampiciN LinEzolid for TBM (IMAGINE-TBM) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC) treatment for tuberculosis meningitis (TBM). |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2023-12-07 |
| 43 | Improving Physician Vaccine Recommendation Using Social Norms, Trust, and Presumptive Language PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research examines vaccination recommendation perceptions and behaviors of physicians and advanced practice providers. |
DAN ARIELY; | 2023-08-01 |
| 44 | Effect of Probiotic and Zinc Supplementations on The Clinical Outcome in Pediatric Patients With Ventriculitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate the effect of non-antibiotic-based supplemental interventions in the management of ventriculitis among pediatric patients. The study objective is to detect the efficacy of probiotics and zinc when taken simultaneously with antibiotic treatment as immunomodulatory in increasing the recovery rate in pediatric population affected with ventriculitis. |
AIN SHAMS UNIVERSITY | 2023-07-01 |
| 45 | Epidemiological, Clinical and Biological Caracteristics of Patients Presenting With Invasive Meningococcal Disease in The West of France PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: An unusual increase in cases of invasive meningococcal infection between late 2022 and early 2023. These cases sometimes had atypical presentations (large numbers of bacteremias without meningitis). The distribution of serogroups was also unusual in our center (large number of serotype Y meningococcal IMD). This development comes after three years marked by the Corona-Virus-Disease-19 pandemic, which led to a profound change in the behaviors involved in the transmission of infectious diseases. Barrier measures have considerably reduced the population’s exposure to meningococcus, … |
POITIERS UNIVERSITY HOSPITAL | 2023-06-30 |
| 46 | Specific Use-results Study of IMFINZI Intravenous Infusion 120 Mg,500mg in Patients With Curatively Unresectable Biliary Tract Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate onset of adverse drug reactions in patients with curatively unresectable biliary tract cancer who receive IMFINZI in combination with gemcitabine hydrochloride and cisplatin under actual use in the post-marketing setting. |
ASTRAZENECA | 2023-06-07 |
| 47 | Specific Use-results Study of IMJUDO Intravenous Infusion 25mg / IMFINZI Intravenous Infusion 120mg,500mg All Patient Investigation in Patients With Unresectable Advanced or Recurrent Non-small Cell Lung Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To collect information of safety in patients with unresectable advanced or recurrent non-small cell lung cancer who receive combination therapy of IMJUDO, IMFINZI and other platinum-based anti-cancer agents under actual use in the postmarketing setting. |
ASTRAZENECA | 2023-06-02 |
| 48 | Combined HRC, CT Cisternography and MR Cisternography in Assessment of Active CSF Rhinorrhes Compared to Operative Findings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the diagnostic accuracy of combined high resolution CT, CT cisternography and MR cisternography in pre operative assessment of active CSF leak, compared by endoscopic sinus surgery. |
GHADA ABDELSABOUR MOHAMED; | 2023-05-01 |
| 49 | Modalities of Surgical Treatment of Chiari Malformation Disease : Clinical Study and Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of postoperative outcomes of Chiari type I Malformation Patients at Department of Neurosurgery Assiut University Hospital . |
AHMED HAMDY HUSSEIN; | 2023-04-01 |
| 50 | Retrospective, Single Center, Single Arm Post Market Clinical Follow-Up (PMCF) Study on The Performance and Safety of Lyoplant® Used for The Replacement and Extension of Connective Tissue Structures in Neurosurgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Retrospective, single center, single arm PMCF study on the performance and safety of Lyoplant® used for the replacement and extension of connective tissue structures in neurosurgery. |
AESCULAP AG | 2023-04-01 |
| 51 | Treatment Outcome With Antibiotic Use and Its Resistance Pattern Among Patient With Neonatal Sepsis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Determine Treatment outcome with antibiotic use and its resistance pattern among neonatal sepsis patients |
ASSIUT UNIVERSITY | 2023-03-31 |
| 52 | Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children – An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Autonomic Nervous System (ANS) regulates the inflammatory response in real time, just as it controls heart rate and other vital functions. Many studies have investigated induced stimulation of the vagus nerve and its therapeutic effect in inhibiting TNFα (Tumor Necrosis Factor alpha) secretion, and therefore the risk of hypotension, septic shock, organ dysfunction during inflammation. While the anti-inflammatory effect of the autonomic nervous system on inflammation has been well studied, conversely, … |
HUGUES PATURAL; | 2023-03-29 |
| 53 | Evaluating The Effect of Prophylactic Topical Antibiotic Irrigation on Nasal Packing Colonization Following Endoscopic Skull Base Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an interventional study that will examine the effect of prophylactic topical antibiotics on nasal packing colonization following endoscopic skull base surgery. |
CARL SNYDERMAN; | 2023-03-01 |
| 54 | The Potential Impact of Clindamycin on Neurosurgery Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, open-label, single center, controlled trial. 44 patients that underwent neurosurgery or presented meningitis signs, for whom Clindamycin add-on therapy to assess its effect on neurological complication in relation to Neuron-specific enolase (NSE) and Neurotensin biomarkers levels. |
REHAB WERIDA; | 2023-03-01 |
| 55 | Frequency and Severity of Thrombocytopenia in Neonatal Sepsis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of our study was to find the frequency of thrombocytopenia and its severity in neonates with sepsis |
RAGAB MOHAMED AMIN GHANDOUR; | 2023-03-01 |
| 56 | A Prospective Study to Observe Adverse Effects in Patients Receiving Anti-PD1 Immunotherapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about in the development process of adverse reactions of anti-PD1 immunotherapy. The main question it aims to observe: – The autoantibody profile of patients – The adverse reactions of patients – The changes of immune cells and cytokine in patients |
HONGYAN LI; | 2023-03-01 |
| 57 | Comparison of Duration of CSF Leak in Post Traumatic Patients Managed By Early Lumbar Drain Vs Conservative Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As limited data is available locally and internationally regarding early Lumbar drain and its effect on duration of CSF leak we have decided to compare it conservative treatment. By providing CSF an alternative route for drainage, the fistula site will remain dry. Leakage site won’t be facing CSF pressure, and this will promote early healing of the wound. |
ATIQ UR REHMAN; | 2023-02-21 |
| 58 | ANRS 12404 TIMPANI: Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis MeNIngitis: A Phase II, Multicenter, Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized phase II clinical trial which aims to assess the impact on 3-month mortality and safety of adding adalimumab to standard treatment (anti-tuberculosis drugs and corticosteroids) in HIV patients with tuberculosis meningitis in 3 countries (Brazil, Mozambique, and Zambia). |
NATHALIE DE CASTRO; | 2023-02-15 |
| 59 | The Impact of Postoperative Bed Rest on The Repair of CSF Leakage After Transnasal Transsphenoidal Pituitary Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Postoperative CSF leakage is a well-known complication that might occur after transnasal transsphenoidal adenomectomy at an incidence of 0.5-15% according to different literature reports. Persistent CSF leakage may lead to intracranial hypotension or meningitis, therefore aggressive management is mandatory. The treatment is immediate repair during transsphenoidal surgery once intraoperative CSF leakage is identified, with the adjunct of postoperative bed rest and/or lumbar drainage. However, due to the advances in endoscopic endonasal skull base surgery, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2023-01-01 |
| 60 | Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial 3 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This pivotal, confirmatory trial seeks to independently verify the results observed in the EnACT Phase II Stage 2 trial (MB-70007). |
DAVID R BOULWARE; | 2023-01-01 |
| 61 | Intranasal Dexmedetomidine Versus Intravenous Dexmedetomidine for Improving Quality of The Operative Field in Functional Endoscopic Sinus Surgery: A Randomized Triple-Blind Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: compare intranasal dexmedetomidine versus intravenous dexmedetomidine for improving quality of the operative field in Functional endoscopic sinus surgery |
MOHAMED FOUAD ALGYAR; | 2022-12-20 |
| 62 | Comparison of Analgesic Effects of USG-Guided Caudal Versus Ilioinguinal/Iliohypogastric Nerve Block Techniques for Inguinal Surgeries in Children, A Randomized Controlled Trial. PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to compare the analgesic effectiveness of caudal analgesia to ilioinguinal regional analgesia techniques in children undergoing inguinal surgeries. Both techniques will be done under ultrasound gaudiness, using the same local anesthesia. 128 patients will be included in this study, 64 for each technique. This study aims to know the best regional analgesia technique in children undergoing inguinal surgeries, reduction in rescue analgesia postoperatively, postoperative length of stay, and early resumption of postoperative activity. The patients will be followed up 30 minutes after the end of anesthesia in PACU, postoperatively in Ward at 2 Hours, 3 hours, … |
JYOTI BURAD; | 2022-12-06 |
| 63 | Different Approaches of Spinal Anesthesia in Patients Undergoing Cesarean Section: Midline, Paramedian and Taylors Approach PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare different approaches of spinal anesthesia in pregnant females who are having cesarean section. The main aim is • Which approach is better in terms of avoiding intraoperative and post operative complications Participants will be given anesthesia by 1. Midline approach 2. paramedian approach 3. Taylors approach |
MUHAMMAD ALI FAYYAZ; | 2022-11-22 |
| 64 | Using Share Decision Making With Patient Decision Aids to Help The Infant Family to Decide Whether The Baby Will Receive The Third Primary Dosing Pneumococcal Conjugate Vaccine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococcal infection is one the common infectious disease in the world. Pneumococcal conjugate vaccine may decrease the incidence of pneumococcal infection. In Taiwan, infants usually received 2 primary dosing pneumococcal conjugate vaccines . The third primary dose of pneumococcal conjugate vaccine is still not included in public health insurance. Some infants in Taiwan did not receive the third primary dose of pneumococcal vaccine. Share decision making (SDM) with patient decision aids (PDA) provide information to infant family and to help them in making decisions about their baby’s vaccination. We develop a PDA administered for baby’s family to decide whether the baby will receive the third primary dosing pneumococcal conjugate vaccine. |
TAIPEI MEDICAL UNIVERSITY SHUANG HO HOSPITAL | 2022-10-01 |
| 65 | Investigating Visuo-spatial Abilities and Psychological Effects in West Nile and Multiple Sclerosis Patients with A Focus on A Possible Rehabilitation Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to investigate visuospatial abilities and psychological outcomes in patients with multiple scleroris (MS) and patients with West Nile virus infection (vWN). Patients will undergo a specific neuropsychological and psychological evaluation. Afterwards, patients will receive 10 sessions of cognitive training integrating digital exercises and prismatic lenses. At the end of the treatment, patients will be re-evaluated to explore for potential changes in the cognitive and psychological profile. |
IRCCS SAN CAMILLO VENEZIA ITALY | 2022-09-21 |
| 66 | Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Feto-placental Doppler (Early GRAFD) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicentre, open-label, randomized controlled trial. A total of 598 singleton pregnancies with an EFW ≤10th percentile at <32+0 weeks will be recruited and randomly allocated to either the control or the intervention group. In the control group, standard Doppler-based management will be used. In the intervention group, different soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) cutoffs will be incorporated to the current protocol to adjust the frequency of ultrasounds and to plan elective delivery. |
MANEL MENDOZA; | 2022-09-01 |
| 67 | Clinical Study of Amphotericin B Colloidal Dispersion (ABCD) in The Treatment of Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and safety of ABCD in the treatment of cryptococcal meningitis in non-HIV patients at week 4, the end of induction therapy, week 10 and the end of consolidation therapy. |
LI TAISHENG; | 2022-08-22 |
| 68 | Validating Clinical Decision Aids for The Assessment and Management of Febrile Infants Presenting to Emergency Care in The UK and Ireland PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Febrile infants under 3 months of age represent a high risk group for serious bacterial infection (SBI) with approximately 10-20% having bacteremia, meningitis or urinary tract infection. The assessment of febrile infants is challenging, and current National Institute for Health and Care Excellence (NICE) guidance advocates a cautious approach with the majority of infants requiring a septic screen, parenteral broad-spectrum antibiotics, … |
THOMAS WATERFIELD; | 2022-08-01 |
| 69 | Causes and Management of Aseptic Meningitis : A Retrospective Cohort Study in Strasbourg University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The diagnostic and therapeutic management of patients with aseptic meningitis is a challenge for the practitioner. There are many etiologies of this condition (infectious, inflammatory, neoplastic, drug-induced), which it is necessary to know how to evoke and look for specifically. |
ANNE-SOPHIE KORGANOW; | 2022-05-20 |
| 70 | Observational Pilot Study With TachoSil As A Ventricular Sealant PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The working hypothesis in this study is that after entering the cerebral ventricular system the sealing with TachoSil is effective and safe. A more specific hypothesis is that the use of Tachosil for brain surgery with ventricular entry reduces the number of postoperative complications (hydrocephalus, CSF leak, meningitis and pseudomeningocele). |
PILAR TEIXIDOR RODRIGUEZ; | 2022-05-01 |
| 71 | A Phase 3 Trial to Evaluate The Safety, Immunogenicity, and Non-Interference With Concomitant Routine Vaccines, of A Meningococcal Serogroup ACYWX Conjugate Vaccine (NmCV-5) in Comparison With MenACWY-TT Conjugate Vaccine in Healthy Malian Infants PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Infants aged 9 months will be randomized to receive a meningococcal vaccine at 9 months or 15 months. Infants randomized to the 9-month age group will be further randomized in a 2:1 ratio to receive a single dose of the experimental meningococcal vaccine (NmCV-5) or a single dose of the comparator meningococcal vaccine (MenACWY-TT). Prospectively identified and consented infants randomized to the 15-month age group will return when aged 15 months and will be randomized in a 2:1 ratio to receive a single dose of NmCV-5 or a single dose of MenACWY-TT. |
WILBUR CHEN; | 2022-03-24 |
| 72 | Impact of Post-ARDS Covid Sedation on Persistent Neuroinflammation (PETDEXDOCOVID) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: ICU Patients admitted after ARDS due to COVID infection should be weaned from invasive mechanical ventilation as quickly as possible. 60% of ARDS patient after COVID infection admitted in ICU developp a delirium during mechanical ventilation weaning, serious event that can lead to death or acute and late complications since 30% of patients who had a delirium in ICU develop cognitive sequelae. Based on epidemiological arguments and mouse models, severe neuroinflammation is considered to be one of the physiopathological mechanisms causing delirium during ventilatory weaning. In addition to its sedative properties, dexmedetomidine exhibits neuroprotective effects. In experimental models, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-03-21 |
| 73 | Phase I/II Clinical Trial of Intrathecal Pemetrexed As First Line Intrathecal Chemotherapy in Patients With Leptomeningeal Metastasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intrathecal chemotherapy is one of the most important treatment modalities for leptomeningeal metastasis of solid tumors. In the previous study(Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastasis From Non-small Cell Lung Cancer: A Prospective Pilot Clinical Trial. ClinicalTrials.gov identification number: NCT03101579), pemetrexed presented feasibility of intrathecal administration. Pemetrexed at 10 mg dose level on the schedule of 1-2 times per week was recommended as an intrathecal administration agent for patients with refractory leptomeningeal metastases from non-small-cell lung cancer in the previous study. Moreover, … |
ZHENYU PAN; | 2022-02-21 |
| 74 | Diagnostic Accuracy of Imaging Findings in Tubercular Meningitis/Spinal Tubercular Arachnoiditis and Correlation With Outcomes in Patients With Tubercular Meningitis, Spinal Tubercular Arachnoiditis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this Diagnostic accuracy study is – To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and – To study the correlation of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis with clinical outcomes after completion of therapy – Secondary objectives – To study the proportion of patients having clinical or imaging features of spinal tubercular arachnoiditis – To study the factors determining outcomes in patients with spinal tubercular arachnoiditis – … |
ARUNMOZHIMARAN ELAVARASI; | 2022-01-27 |
| 75 | A Randomized Trial of The Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele Sac Repair PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Meningomyelocele is a common congenital neural tube defect. To reduce complications, early surgery and a multidisciplinary approach is needed. In this study, the investigators administered platelet-rich plasma (PRP) to newborns with meningomyelocele following corrective surgery to minimize cerebrospinal fluid (CSF) leakage and accelerate the healing of the immature pouch tissue. The investigators compared these with a control group that did not receive PRP. Patients and Methods: Of the 40 newborns who were operated on with the diagnosis of meningomyelocele, 20 patients received PRP after surgical repair, and 20 were followed up without PRP. In the PRP group, … |
ÖZKAN ARABACI; | 2022-01-15 |
| 76 | Safety, Tolerability and Effects on The Microbiome of Neonatal Administration of Lactiplantibacillus Plantarum ATCC 202195 With or Without Fructooligosaccharide for One or Seven Days: A Phase II Randomized Placebo-controlled Trial in Dhaka, Bangladesh PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Sepsis is a life-threatening clinical syndrome and a leading cause of neonatal deaths worldwide. The burden of neonatal sepsis and severe infection (SI) is particularly high in areas of South Asia and other resource-limited settings. The goal of the Synbiotics for the Early Prevention of Severe Infections in Infants (SEPSIS) phase II L. plantarum trial is to generate knowledge on the safety, tolerability and effects on the microbiome of Lactiplantibacillus plantarum, with or without fructooligosaccharide, in infants (birth to 60 days of age) in Dhaka, … |
DANIEL ROTH; | 2022-01-07 |
| 77 | Pneumococcal Conjugate Vaccine 13 (PCV13) Schedule Change From 3+0 to 2+1 to Accelerate Reduction in Pneumococcal Vaccine Serotype Carriage in Blantyre, Malawi: An Effectiveness Study PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococcal conjugate vaccines (PCV) have been shown to be effective against invasive pneumococcal disease (IPD; including pneumococcal meningitis and sepsis) and all-cause mortality among young children when introduced into infant expanded programs on immunization (EPI). Colonization of the nasopharynx by Streptococcus pneumoniae is a necessary prerequisite to pneumococcal disease. Critically important to the population impact of PCV is therefore reducing vaccine serotype (VT) carriage prevalence, and therefore reducing both disease and onward transmission to vulnerable individuals. Thus, as well as protecting the vaccinated individual (direct protection), … |
TODD SWARTHOUT; | 2022-01-01 |
| 78 | A Single-center, Randomized, Blind, Positive Control Phase III Clinical Trial to Evaluate Immunogenicity and Safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Healthy Volunteers Aged From 3 to 5 Months PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the immunogenicity and safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in healthy volunteers aged from 3 to 5 months. |
BEIJING ZHIFEI LVZHU BIOPHARMACEUTICAL | 2021-12-18 |
| 79 | Neostigmine and Atropine for The Treatment of Post Dural Puncture Headache After Known Dural Puncture With A Tuohy Needle: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate Neostigmine and Atropine to treat post-dural puncture headache (PDPH) to reduce the proportion of postpartum women with a PDPH requiring epidural blood patch (EBP) who developed a PDPH after accidental dural puncture. |
MARK D. ROLLINS; | 2021-11-19 |
| 80 | The Associations Between Perioperative Depression or Anxiety, Salivary Cortisol and Α-amylase, and Administered Anesthesia Type in Knee Arthroscopy With Anterior Cruciate Ligament Reconstruction (ACLR): Prospective, Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Perioperative depression and/or anxiety play a critical role in patient presentation, satisfaction and outcomes. The aim of this study is to assess the level of perioperative depression and/or anxiety in patients with arthroscopic knee surgery and to evaluate their relationship with anesthesia approach (general anesthesia or non general anesthesia). The perioperative characteristic of depression or anxiety is assessed by Hospital Anxiety and Depression Scale (HADS) questionnaires and the level of salivary cortisol, salivary α-amylase (sAA) and blood glucose. |
CONGCONG HUANG; | 2021-10-20 |
| 81 | Strengthening The Evidence for Policy on The RTS,S/AS01 Malaria Vaccine: Assessment of Safety and Effectiveness Using Case-control Studies Embedded in The Malaria Vaccine Pilot Evaluation PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The ongoing Malaria Vaccine Pilot Evaluation (MVPE) is being conducted in Ghana, Malawi and Kenya through community and sentinel hospital surveillance systems and a series of household surveys (to measure vaccine coverage). The Malaria Vaccine Pilot Evaluation-Case Control (MVPE-CC) registered here as observational study is embedded within MVPE comprising case-control studies of clinical and mortality outcomes. Each case will require four controls, and caregiver informed consent will be required prior to study activities. These observational case control studies will measure as complementary information to what is being collected through MVPE: 1. Safety among children who received the malaria vaccine, … |
KWAKU POKU ASANTE; | 2021-10-18 |
| 82 | COVID-19 Booster Vaccination in Persons With Multiple Sclerosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The success of the U.S. vaccination program against SARS-Cov-2 is shown by a dramatic drop in infection rates, hospitalizations and deaths.However, it appears that many persons who take medications that chronically suppress the immune system do not produce neutralizing antibodies to COVID-19 proteins in response to vaccination. This group includes a significant number of persons with multiple sclerosis (PWMS), … |
JOSEPH B GUARNACCIA; | 2021-10-15 |
| 83 | An Observational, Retrospective, Clinical Performance Study Testing Residual Specimens of Cerebrospinal Fluid Obtained By Lumbar Puncture From Meningitis/Encephalitis Subjects Using The QIAstat-Dx® Meningitis/Encephalitis Panel PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Study for performance evaluation of the QIAstat-Dx® Meningitis/Encephalitis Panel in comparison with other chosen comparator methods. |
QIAGEN GAITHERSBURG | 2021-10-08 |
| 84 | EXtended Use of FOsfomycin for The Treatment of CYstitis in Primary Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cystitis is the most frequent reason for women to visit their general practitioner. More than 600.000 women suffer from urinary tract infections in The Netherlands each year. Currently, the 1st choice treatment for uncomplicated cystitis is nitrofurantoin (NIT) for 5 days. The second choice is 3 gram fosfomycin-trometamol (FT) in a single dose. FT is increasingly prescribed because it has few side-effects and it has a patient-friendly dosing scheme. Previous research did not show significant difference in efficacy between fosfomycin and nitrofurantoin, … |
MJM BONTEN; | 2021-09-06 |
| 85 | Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective randomized controlled study examines whether the type of glove used (sterile vs clean) for cervical examination to assess progression in labor impacts the rates of intrapartum and/or postpartum infection in patients during labor or induction of labor at term. |
STACY SLAT; | 2021-09-02 |
| 86 | Reduction of Adverse Events and Re-Presentation to Medical Care After Intravenous Immunoglobulin Treatment in Children With Immune Thrombocytopenia With A Scheduled Post-Infusion Medication Strategy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a single hospital system, single-arm year-long pilot to evaluate the feasibility of enrolling children with ITP who are receiving IVIG for treatment of disease to a scheduled post-infusion medication for 72 hours following IVIG infusion. This year-long feasibility pilot will test the (1) feasibility of enrollment and the willingness of families to participate in a scheduled medication regimen and (2) adherence of patients and families to the scheduled medication regimen. Clinical outcomes, as defined by rates of headache or nausea/vomiting or other adverse event following IVIG, return to medical care, … |
MEGAN GILBERT; | 2021-09-02 |
| 87 | A Natural History Study to Assess The Clinical Outcomes of Patients With Complement Factor I Deficiency-Mediated Disease Related Papers Related Patents Related Grants Related Experts View Highlight: This study will follow participants with a disease which is associated with an absence or deficiency in Complement Factor I (CFI) as confirmed in the CFI-001 screening study. |
CATALYST BIOSCIENCES | 2021-08-31 |
| 88 | Validation of A Predictive Rule for The Diagnosis of Viral Meningitis in Adult Emergency Departments PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Meningitis is the development of an inflammatory reaction in the meningeal space, most often of infectious origin. Many pathogens can cause meningitis, the severity of which varies greatly. Patients presenting with a febrile meningeal syndrome are most often managed in the emergency room, where the challenge for physicians is to quickly differentiate bacterial and viral meningitis. Viral meningitis is the most common, … |
JEAN-CHRISTOPHE CALLAHAN; | 2021-08-26 |
| 89 | A Phase IV Double Blind Randomised Controlled Trial (DBRCT) to Investigate The Effect of PCV-13 and PPV-23 on Pneumococcal Colonisation Using The Experimental Human Pneumococcal Challenge (EHPC) Model in Healthy Adults PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effect of PCV-13 and PPV-23 vaccination versus control on experimental pneumococcal colonisation of 2 clades of serotypes 3 and 6B at 1 month and 6 months post vaccination respectively, using the EHPC model. |
LIVERPOOL SCHOOL OF TROPICAL MEDICINE | 2021-07-28 |
| 90 | Phase 1/2a Trial of Placental Mesenchymal Stem Cells for Repair of Fetal Myelomeningocele PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Spina bifida, or myelomeningocele (MMC), is a disorder where the lower part of the spinal cord of the fetus is exposed, meaning there is no bone or skin covering it. This is dangerous because the spinal cord contains cells which control one’s ability to move their legs and walk, and also to be able to urinate and have bowel movements normally. One of the current treatments for fetal MMC is to perform a surgery on the fetus before it is born which has many names including in utero surgery, prenatal surgery, … |
DIANA LEE FARMER; | 2021-06-21 |
| 91 | The Role of Serum Procalcitonin in Diagnosis and Detection of Outcome of Acute Bacterial Meningitis in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Meningitis is one of the most common central nervous system (CNS) infections encountered in infants and children. The source of infection in meningitis can be bacterial, viral, fungal, or parasitic in origin . Bacterial meningitis is a paediatric emergency with high mortality and morbidity rate. Hence it must be diagnosed and treated promptly. But the similar clinical presentation often makes it difficult to differentiate bacterial and non-bacterial aetiologies in children . |
MARINA WAHIB SHAWKY; | 2021-06-15 |
| 92 | Early Diagnosis and Treatment Monitoring of Native and Device-associated Meningitis Using D-lactate, A Pathogen-specific Diagnostic Biomarker in Cerebrospinal Fluid PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Device-associated meningitis is a severe complication after implantation of various central nervous system (CNS) devices such as ventriculoperitoneal (VP) and ventriculoatrial (VA) shunts, external ventricular drains (EVD), lumbar drains (ELD) and intrathecal pumps. In contrast to native meningitis, these infections are hard to diagnose both clinically and on the laboratory basis due to (i) atypical clinical manifestation, (ii) overlapping inflammation following surgery, and (iii) common culture negativity due to previous antibiotic therapy and slow growth of low-virulent pathogens. Also, … |
ANDREJ TRAMPUZ; | 2021-06-01 |
| 93 | An Observational Clinical Performance Evaluation Study Testing Residual Specimens of Cerebrospinal Fluid Obtained By Lumbar Puncture From Meningitis/Encephalitis Subjects Using The QIAstat-Dx® Meningitis/Encephalitis Panel PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Study for performance evaluation of the QIAstat-Dx® Meningitis/Encephalitis Panel in comparison with other chosen comparator methods. |
QIAGEN GAITHERSBURG | 2021-05-06 |
| 94 | Pharmacokinetics and Tolerability of Adjunctive Linezolid for The Treatment of Tuberculous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II randomized open-label trial of high versus standard dose rifampin (RIF) with or without linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at Masaka Regional Referral Hospital in Uganda. Initial randomization will be to high (35 mg/kg/day) versus standard (10 mg/kg/day) dose oral rifampin for the first 4 weeks of intensive therapy. Participants will then undergo a second randomization to linezolid 1200 mg daily versus no linezolid for the first 4 weeks of therapy. The primary aims are (1) to determine the cerebrospinal fluid and plasma pharmacokinetics of adjunctive LZD 1200 mg daily in TBM patients receiving high or standard dose RIF and (2) to evaluate the tolerability of a 4-week course of LZD in TBM patients. |
FELICIA CHOW; | 2021-05-05 |
| 95 | BCG Vaccination Scar Formation in Children Under Five Years :Factors Affecting Its Formation and Subsequent Adverse Effects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study of BCG Vaccination scars of under five years old children . Estimation of the frequency of children without BCG scar after BCG vaccine . Evaluation of factors which may affect scar formation . Tuberculin skin test response in children without BCG scar . Frequency of vaccine adverse effects as injection-site abscess, lymphadenitis, severe local reaction, and disseminated BCG infection. |
SHIMAA ABD ELHAMID MAHRAN; | 2021-05-01 |
| 96 | Short Intervention and Measurement of Pharmacokinetics of Linezolid in Tuberculosis Meningitis: A Pharmacokinetics and Safety/Tolerability Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis meningitis (TBM) is the most severe manifestation of TB, resulting in death or neurological disability in up to 50% of affected patients, despite antibacterial treatment. This TBM treatment follows the model for pulmonary TB by using the same first-line TB drugs (a combination of rifampicin, isoniazid, pyrazinamide and ethambutol) and the same dosing guidelines, although it is known that penetration of two of these drugs (rifampicin and ethambutol) into cerebrospinal fluid (CSF) is limited. Improvement of treatment of TBM is urgently needed. To do so, … |
AHMAD RIZAL GANIEM; | 2021-04-21 |
| 97 | Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways. Therefore, we conducted this multicenter, prospective, and randomized controlled study. It was designed to evaluate the diagnostic performance and its impact on the outcomes of the patients enrolled. As such, we came to the results of the optimal process of diagnosis and treatment strategy of encephalitis/meningeal syndromes with improved effective treatments. |
WEN-HONG ZHANG; | 2021-04-14 |
| 98 | Free Middle Turbinate Flap for Repair of Low Flow Cerebrospinal Fluid Leak PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Limited literature has been reported the use of free middle turbinate flap during an endoscopic approach to treat cerebrospinal fluid (CSF) leak, and the results were inconclusive. The overall purpose of this study was to assess the efficacy and safety of free middle turbinate flap in reparing CSF leak during an endoscopic approach. |
QIANGPING WANG; | 2021-04-01 |
| 99 | Analysis of The Cognitive-behavioral Dysfunctions Profile and The Potential of Neuroplasticity in Patients With Brain Tumors Subjected to Selected Radiotherapy Techniques and The Possibility of Their Compensation By Psycho-physical Training PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary and secondary brain tumors are a constant challenge for the medicine. Tissue sensitivity to ionizing radiation differs and depends on numerous factors and the same dose of radiation may produce different effects in particular structures of the CNS. It can also affect the surrounding healthy tissues and lead to adverse effects like the cognitive or physical function impairment. One of brain structures most sensitive to ionizing radiation is the limbic system, especially the hippocampus, because it is here that the postnatal neurogenesis takes place via neural stem cells, … |
KATARZYNA HOJAN; | 2021-04-01 |
| 100 | Study of The Inflammatory Response to Enterovirus Meningitis in Newborns, Infants and Children, As Assessed By Cytokine Levels in Blood and Cerebrospinal Fluid. Case-control Comparison Using An Existing Cohort PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Enteroviruses (EV) are the most frequent cause of acute meningitis in the paediatric population. Detection of enterovirus in cerebrospinal fluid (CSF) specimens by Polymerase Chain Reaction (PCR) is the gold standard diagnostic test. Recently, our laboratory published the BLEDI study which highlighted the interest of detecting EV in the blood of the paediatric population : (i) EV was found in more than a quarter of cases in the blood of infants admitted to hospital with isolated fever and (ii) detection of EV was more frequent in the blood than in CSF in neonates and infants with isolated fever, … |
CHRISTINE ARCHIMBAUD; | 2021-04-01 |
| 101 | A Phase III, Open-label, Prospective, Multicenter Study to Assess Efficacy, Safety, and Pharmacokinetics of Kedrion Intravenous Human Normal Immunoglobulin (IVIg) 10% in Pediatric Patients Affected By Primary Immunodeficiency Disease (PID) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess efficacy, safety and pharmacokinetics of Kedrion Immunoglobulin 10% (KIg10) in pediatric patients with Primary Immunodeficiency Disease (PID). |
CHIARA AZZARI; | 2021-03-31 |
| 102 | Utility of Ultrasound-Guided Site Marking in Pediatric Lumbar Punctures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The standard way to identify landmarks in the spine before inserting a needle for a lumbar puncture is to feel by touch. The purpose of this research is to determine if doing an ultrasound to identify landmarks before performing a lumbar puncture will improve the first-time success rate of the needle insertion in pediatric patients. |
RAHUL PANDEY; | 2021-03-15 |
| 103 | Prospective, Multicentre Evaluation of The Accuracy of CAD4TB and C-reactive Protein Assay As Triage Tests for The Diagnosis of Pulmonary Tuberculosis in Presumptive Adult TB Patients (TB TRIAGE+ Accuracy) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In the TB TRIAGE+ ACCURACY study, the accuracy of the following products will be determined: – CAD4TB (Delft Imaging System, NL), a digital chest x-ray analysis software – Afinion CRP assay (Alere Afinion, USA), … |
KLAUS REITHER; | 2021-02-15 |
| 104 | Intensified Tuberculosis Treatment to Reduce The Mortality of HIV-infected and Uninfected Patients With Tuberculosis Meningitis: A Phase III Randomized Controlled Trial (Acronym: INTENSE-TBM) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: INTENSE-TBM is randomized controlled, phase III, multicenter, 2 x 2 factorial plan superiority trial assessing the efficacity of two interventions to reduce mortality from tuberculous meningitis (TBM) in adolescents and adults with or without HIV-infection in sub-Saharan Africa: – Intensified TBM treatment with high-dose rifampicin and linezolid, compared to WHO standard TBM treatment. – Aspirin, compared to not receiving aspirin. The trial will be open-label for anti-TB treatment and placebo-controlled for aspirin treatment. |
FABRICE BONNET; | 2021-02-07 |
| 105 | Immunisation for Adolescents Against Serious Communicable Diseases PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to implement a targeted 4CMenB immunisation program in young people aged 14-19 years in the Northern Territory (NT). As part of the NT program consenting 14-19 year olds will receive 2 doses of the licensed 4CMenB vaccine. An oropharyngeal swab will be collected on the same day as the first dose of the vaccine and 12 months later to assess carriage of Neisseria meningitidis. The first swab will assess baseline carriage prevalence among 14-19 year olds in the NT. The swab taken 12 months later will provide data on the change in carriage that may occur after implementation of the immunisation program. Emerging evidence suggests that the 4CMenB vaccine may be protective against gonorrhea. Therefore, vaccine effect (impact and effectiveness) against both invasive meningococcal disease (IMD) and gonorrhea in the NT will be assessed using data from the above study comparing notifications between vaccinated and unvaccinated as well as comparing pre and post implementation periods. |
HELEN MARSHALL; | 2021-02-01 |
| 106 | Short- Term Follow Up Of Neonates Born With Neural Tube Defect PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Neural tube defects (NTD), which is the most common anomaly of the central nervous system, which can be diagnosed during antenatal period, brings many problems both in the neonatal period and in advanced ages. Open neural tube defects, in particular, progress with sensory-motor deficits due to the risk of infection and neural tissue loss from birth, and should be followed closely from the neonatal period. Newborns born with a neural tube defect should be operated within the first 72 hours postnatal and the defect should be closed. In this hospital, … |
UMIT AYSE TANDIRCIOGLU; | 2021-02-01 |
| 107 | Long Term Follow Up of Patients With Thoracolumbar Spondylodiscitis Treated Surgically By Posterior Approach in Assiut University Hospitals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the long term outcomes of patients with thoracolumbar spondylodiscitis treated surgically by posterior approach. Outcomes include bony fusion, neurological improvement, pain improvement, implant related complication, recurrence of infection and or reoperation rate |
MICHEAL BASSEM ELIA; | 2021-01-31 |
| 108 | The Effect and Safety of Three Initial Introduction Treatments on HIV-infected Patients With Cryptococcal Meningitis: A Multi-center, Random and Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Three induction treatment strategies [ voriconazole +5FC vs. amphotericin deoxycholate (0.4-0.5 mg/kg/d)+5FC vs. amphotericin deoxycholate (0.7-1.0 mg/kg/d)+5FC ] for HIV-infected patients with cryptococcal meningitis were compared. |
LIJUN XU; | 2021-01-25 |
| 109 | Protecting Brains and Saving Futures – The PBSF Protocol: A Prospective Multicenter and Observational Study on The Use of Telemedicine for Neurocritical Care in High-risk Newborns in Brazil PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care. Such initiative involves the use of standardized protocols, continuous and specialized brain monitoring with electroencephalography (EEG), amplitude integrated EEG (aEEG) and Near Infrared Spectroscopy (NIRS), neuroimaging and training. Brazil is a very large country with disparities in health care assessment; some neonatal intensive care units (NICUs) are not well structured and trained to provide adequate neurocritical care. However, … |
GABRIEL VARIANE; | 2021-01-01 |
| 110 | Central Nervous System Disorders Following Hematopoietic Stem Cell Transplantation: A Prospective Observational Trial From The Infectious Diseases Working Party and The Transplant Complications Working Party of The European Society for Blood and Marrow Transplantation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: All patients undergoing allogeneic or autologous HSCT at the participating centres will be observed. Once a diagnosis of CNS disorder is made, additional data will be reported for these patients. We will identify clinical and diagnostic characteristics such as cerebrospinal fluid (CSF) and neuroimaging patterns, risk factors, response to treatment (including novel antifungal agents such as isavuconazole) and outcome. In addition, risk factors for CNS disorders after allogeneic and autologous HSCT will be analyzed using a prospectively assessed matched control group. In the future, this study might be the basis for an interventional trial (e.g. using a prophylactic approach). |
MARTIN SCHMIDT-HIEBER; | 2021-01-01 |
| 111 | Clinical Study of Individualized Vancomycin Dosing Based on Population Pharmacokinetic Model for Severe Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the clinical efficacy of individualized dosing based on the population pharmacokinetics (PK) model and empirical dosing of vancomycin in participants with severe infections. It aims to answer whether individual vancomycin dosing based on population PK model is superior to empirical dosing in terms of clinical efficacy and safety. Participants will be randomly divided into experimental group and control group. The experimental group will be guided by the population PK model for individual dosing, and the control group will be given empirical dosing. Demographic data, clinical characteristics of participants, … |
HAINAN ZHANG; | 2021-01-01 |
| 112 | Efficacy and Safety of Cyclophosphamide in The Treatment of Refractory Proliferative Arachnoiditis in Central Nervous System Tuberculosis- A Randomized Double Blinded Placebo Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tubercular meningitis occurs in around 10% of those with extrapulmonary tuberculosis and is a major cause of mortality and morbidity. Inspite of effective Anti-tubercular drugs, still around 30% of patients develop complications due to arachnoiditis such as spinal tubercular radiculomyelitis, optico-chiasmatic arachnoiditis, development of new tuberculomas after starting therapy etc. which are probably immune mediated inflammatory responses due to paradoxical reaction to ATT. The management of arachnoiditis is far from satisfactory. High dose methylprednisolone, intrathecal hyaluronic acid, thalidomide have been tried in small case series and case reports. However, … |
ARUNMOZHIMARAN ELAVARASI; | 2021-01-01 |
| 113 | Meningitis Encephalitis: A Metagenomics-Based Etiology & Epidemiology Research (MEMBER Research) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Autoimmune encephalitis (AE) is caused by abnormal immune response mediated by autoimmune antibodies of patients, which can be detected by a serial of autoimmune antibodies[4,5,6,7]. At present, the traditional infection diagnosis mainly relies on microbial culture method, which has the characteristics of long cycle, high cost, low detection rate and complex detection process. About 30-60% of encephalitis have unknown etiology[2,3]. On the other hand, the diagnosis and classification of noninfectious encephalitis mainly depend on the detection of autoimmune antibodies, the scope of diagnosis and differential diagnosis is limited, … |
JIA WEI WANG; | 2020-12-31 |
| 114 | The Evaluation of The Effect of Wharton’s Jelly Mesenchymal Stem Cells (WJMSCs) on The Immune System of Patients With Amyotrophic Lateral Sclerosis (ALS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the safety of intrathecal administration of Wharton’s Jelly Mesenchymal Stem Cells (WJMSC) and the impact on the immune system of patients with Amyotrophic Lateral Sclerosis. |
POLSKI BANK KOMOREK MACIERZYSTYCH JSC PBKM | 2020-12-02 |
| 115 | Pneumococcal Nasopharyngeal Colonization As Predictor of Community-Acquired Pneumonia in Adults With Chronic Diseases: A Real-word Evidence, Prospective, Observational, Multicenter, Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Streptococcus pneumoniae (pneumococcus) is a commensal bacterium, often isolated in the nasopharynx of preschool children and older adults with weakened immune systems, a pathogen that remains the leading cause of Community-Acquired Pneumonia (CAP) and invasive pneumococcal disease (IPD) such as Sepsis and Meningitis. CAP is the sixth leading cause of overall mortality and the first cause of infectious disease in Colombia and the world (Montúfar et al, 2013; GBD, 2016; WHO, 2018), and both its incidence and prevalence have remained stable over the past 3 decades. Likewise, … |
LUIS F REYES; | 2020-12-01 |
| 116 | Predictors Of Stroke Outcome In Children Admitted To Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke can be defined as an abrupt loss of brain function that is caused by decreased cerebral blood flow. Stroke can occur at all stages of life, but presentation is variable depending on age, involved artery, and underlying risk factors. |
AHLAM ABDELBAST MOHAMAD; | 2020-12-01 |
| 117 | A Pivotal Clinical Trial Evaluating The Safety and Effectiveness of Adherus™ AutoSpray and Adherus™ AutoSpray ET Dural Sealant When Used As A Dural Sealant in Spinal Procedures PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test an experimental device, the Adherus AutoSpray and Adherus AutoSpray ET Dural Sealant, in spinal surgical procedures. This study is being done to compare Adherus AutoSpray and Adherus AutoSpray ET Dural Sealant to DuraSeal Exact Spinal Sealant, which has already received Federal Food and Drug Administration (FDA) approval in spinal procedures. |
STRYKER CRANIOMAXILLOFACIAL | 2020-11-19 |
| 118 | Continuous Preperitoneal Analgesia Versus Thoracic Epidural Analgesia After Open Pancreaticoduodenectomy: A Randomized Controlled Open-labeled Noninferiority Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective randomized open-label noninferiority trial that compares thoracic epidural analgesia and continuous preperitoneal analgesia after open pancreaticoduodenectomy. |
JIN-YOUNG JANG; | 2020-11-13 |
| 119 | Evaluating Pneumococcal Conjugate Vaccine (PCV) Impact on Pneumonia and Pneumococcal Carriage Outcomes in India in Children 1-35 Months in India: Pneumonia Research and Vaccine Impact League PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The leading cause of severe respiratory disease and death in young children is Streptococcus pneumoniae (pneumococcus). An estimated one-fifth of global childhood pneumococcal-related deaths occurred in India. The pneumococcal conjugate vaccine (PCV) is a primary prevention tool against pneumococcal disease that is safe and effective and has been in use in many countries. In alignment with the Government of India’s rollout of PCV sub-nationally in selected districts and states, this two-year observational study will use a non-interventional, … |
ANITA SHET; | 2020-10-13 |
| 120 | A Prospective Observational Study on Assessment of The Soluble Urokinase Plasminogen Activator Receptor in Adult Patients With Covid-19 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is the soluble form of the cell membrane-bound protein urokinase plasminogen activator receptor (uPAR), which is expressed mainly on immune cells, endothelial cells, … |
ATHANASIOS CHALKIAS; | 2020-10-11 |
| 121 | Autonomic Functions in Migraine Patients As A Function of Migraine Status and CGRP Inhibition PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e. whether they are between or during attacks) and whether the CGRP monoclonal antibody (mAb) class of drugs affects the autonomic functions. The aim is not to investigate the effect of CGRP-mAb on migraine frequency. Calcitonin gene-related peptide (CGRP) is a neurotransmitter in the nervous system that plays an essential role in the development of migraine headache. Monoclonal antibodies can block the function of this messenger substance. Several studies have shown that this blockade leads to a reduction in the frequency of migraine. In addition to its role in migraine, CGRP also acts on the blood vessels and the autonomic nervous system. The autonomic nervous system is responsible for everything we have no control over in our body. This includes everything from heart rate and blood pressure to our digestion. |
CHRISTIAN WÖBER; | 2020-10-01 |
| 122 | Clinical Effectiveness and Safety of Amphotericin B With Flucytosine-Fluconazole Therapy for Cryptococcal Meningitis in Patients With HIV Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To study the clinical effectiveness and safety of amphotericin B with flucytosine-fluconazole therapy for cryptococcal meningitis in patients with HIV infection. |
ZIN WIN MAY; | 2020-10-01 |
| 123 | The Norwegian Study of Nervous System Manifestations and Sequelae After COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Neurologic, neuropsychological and neuropsychiatric symptoms, signs and diagnoses are increasingly being reported in COVID-19 patients. However, the extent and implications of such NeuroCOVID involvement, as well as blood and MRI biomarkers for neurological and psychiatric COVID-19-affection and treatments, warrants further studies. The investigator will perform a national study with clinical and biomarker assessments of NeuroCOVID in approximately 150 Norwegian patients, recruited from ongoing COVID-studies in Norway as well as from neurological departments in Norway. The investigator will define the burden of neurological, psychological and psychiatric complications of COVID-19 disease and identify clinical characteristics and biomarkers for both short- … |
ANNE HEGE AAMODT; | 2020-09-01 |
| 124 | Role of Montelukast in Modulation of Response to Sepsis in Preterm Infants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will conduct this study to explore the role of Montelukast in treatment of neonatal sepsis and whether it has an effect on inflammatory markers, the duration of antibiotic use, or on the patients´ outcome. |
HANAN EL-HALABY; | 2020-07-24 |
| 125 | Evaluation of Prime-boost Anti-pneumococcal Vaccination in Patients With Diffuse Large B Cell Lymphoma Treated With Rituximab (EVAPOR Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococcal infections remain frequent and potentially fatal. To prevent them, two anti-pneumococcal vaccines exist: a 13-valent conjugate vaccine (Prevenar®) and a 23-valent polysaccharide vaccine (Pneumovax®). For their utilization, several studies approved a prime-boost strategy. It consist two administer Pneumovax® at least two months later than Prevenar®. Patients with diffuse large B-cell Lymphoma (DLBCL) have a higher-risk to develop a pneumococcal infection. The main reason is immunosuppression, induced by rituximab (B cell depletion), chemotherapy and lymphoma. Patients are treated by immunochemotherapy, combining rituximab (anti-CD20 monoclonal antibody) and conventional chemotherapy (CHOP). However, those patients have a low rate of vaccination (about 15%). |
UNIVERSITY HOSPITAL TOURS | 2020-07-03 |
| 126 | Intraspinal Pressure Monitoring for Acute Traumatic Spinal Cord Injury: A Validation Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intraspinal pressure monitoring has been advanced as a potential technique for evaluating spinal cord perfusion after traumatic spinal cord injury. In this study, the investigators aim to validate the technique for insertion of a fiberoptic pressure monitoring device in the subarachnoid space at the site of injury for measurement of intraspinal pressure and spinal cord perfusion pressure. The primary objective of this study is to validate the methodology of invasive intraspinal pressure monitoring to derive parameters for optimal spinal cord perfusion pressure, … |
PERRY DHALIWAL; | 2020-06-23 |
| 127 | A Randomized Placebo-controlled Double-blinded Trial of The Treatment of MRSA Throat Carriage With Either Standard Decolonization Therapy or Standard Decolonization Therapy Combined With Oral Clindamycin PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the optimal way to treat MRSA throat carriers. |
MONA KATRINE ALBERTHE HOLM; | 2020-05-20 |
| 128 | Comparison Between Two Protocols for Management of Prelabor Rupture of The Membranes at Term PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Prolonged rupture of membranes has been associated with increased risk of chorioamnionitis and endometritis. In this study the investigators will investigate whether an early intervention to augment labor with oxytocin is superior to expected management for spontaneous delivery (up to 24 hours). |
GAL BACHAR; | 2020-05-01 |
| 129 | Multicenter, Randomized, Open-label Non-inferiority Trial, Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at The Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Leptospirosis is a globally distributed neglected tropical disease affecting subtropical and tropical areas, such as the Caribbean and the Indian Ocean, with favorable climatic conditions for disease transmission. It shows a strong seasonality, with epidemic potential especially after heavy rainfall. A recent systematic review by Costa et al. (2015) places leptospirosis among the leading zoonotic causes of morbidity and mortality worldwide, with 1.03 million cases and 58,900 deaths each year. Leptospirosis is an important public health problem, … |
FÉLIX DJOSSOU; | 2020-04-01 |
| 130 | Evaluation of New Biomarker-based Approaches for Improving The Diagnosis of Childhood Tuberculous Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The rapid diagnosis of tuberculosis (TB) in children remains a serious challenge owing to limitations in the existing diagnostic tests. TB meningitis (TBM), an extrapulmonary form of TB, is the most severe manifestation of paediatric TB. TBM results in high morbidity and mortality in children, despite the availability of chemotherapy, mainly due to diagnostic delay. Most tests required for proper TBM diagnosis including analysis of cerebrospinal fluid (CSF) and brain imaging are not available in resource-limited settings e.g., … |
VINZEIGH LEUKES; | 2020-04-01 |
| 131 | Phase II Study of Neoadjuvant Chemoradiation for Resectable Glioblastoma (NeoGlio) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Preoperative therapy has not been well studied in resectable glioblastoma. This study attempts to prospectively assess the feasibility and efficacy of preoperative chemo radiation in improving local control, as this is the predominant mode of failure in these patients leading to poor outcomes. This Phase II study design would be used to proceed with the study treatment after meeting pre-specified events in the initial phase, with goal being to determine whether the new treatment paradigm is sufficiently promising to warrant a major controlled clinical evaluation against the standard therapy. |
ANAND MAHADEVAN; | 2020-04-01 |
| 132 | Evaluation of Antisecretory Factor in Treatment of Severe Traumatic Brain Injury With Multimodal Monitoring PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the addition of Salovum, an egg yolk powder enriched for antisecretory factor, to standard care of participants with severe traumatic brain injury. Half of the participants will be administered Salovum while the other half will be given a placebo egg yolk powder, not enriched for antisecretory factor. Intracranial pressure (ICP), partial brain oxygen pressure (PtbO2), microdialysis of metabolites and inflammatory mediators and trauma intensity level (TIL) will be assessed in all patients. |
PETER SIESJÖ; | 2020-03-10 |
| 133 | Prevention of Epilepsy By Reducing Neonatal Encephalopathy PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to examine if a pragmatic, evidenced based and generalisable intrapartum care bundle involving birth companions and empowering mothers will reduce birth injury-related epilepsy at 18 months of age in India. The care bundle will have four key elements (interventions): (1) birth companion providing constant 1:1 care during labour and early perinatal period; (2) fetal surveillance during active labour by a nurse or midwife using a graphic display Doppler; (3) labour management by an electronic partogram with an ‘alert’ and ‘nag’ feature based on the current WHO guidelines; … |
MINI CHENICHERI; | 2020-03-01 |
| 134 | Soliris to Stop Immune Mediated Death In Covid 19 Infected Patients. A Trial of Distal Complement Inhibition Related Papers Related Patents Related Grants Related Experts View Highlight: Covid-19 has spread rapidly throughout the world causing widespread panic, death, and injury. While this virus is the provocateur, it is often the patient’s own disproportionate immune response which deals the most devastating (and often fatal) damage. A specific part of the immune system, known as the complement, has been shown to cause such damage in other types of coronaviruses. In the SOLID-C19 study, Soliris (Eculizumab) will be used to modulate the activity of the distal complement preventing the formation of the membrane attack complex. By modulating this portion of the immune response, … |
THOMAS PITTS; | 2020-02-27 |
| 135 | Severe Infections and The Intestinal Microbiome in Young Infants in Dhaka, Bangladesh: An Observational Cohort Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Globally, infectious diseases such as sepsis, meningitis and pneumonia are among the leading causes of neonatal deaths. A recent observational study in South Asia highlighted the contribution of both bacterial and viral infections to the burden of illness in infants <60 days of age; however, there remains a need to quantify the risk of severe infection (SI) among newborns in a Bangladeshi population. In collaboration with researchers in Bangladesh, investigators aim to generate knowledge regarding the incidence and risk factors of SI, including the composition of the intestinal microbiome, in young infants (birth to 60 days of age) in Dhaka, ... |
DANIEL ROTH; | 2020-02-12 |
| 136 | The Lived Experience of Participants in An African Randomised Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There has been no previous qualitative study conducted in a low-income setting which has aimed to explore the experience of individuals who enrol into a clinical trial for the management of a life-threatening illness. The investigators plan to collect data from trial participants, their next-of-kin, and researchers working on a multi-site randomised controlled trial for the treatment of HIV-associated cryptococcal meningitis. |
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE | 2020-02-05 |
| 137 | Biochemical Role of Nucleotide Protein -3 That Activate The Interleukin-1B in Epileptic Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is one of common serious neurological malfunction, characterized by recurrent unprovoked seizures. It always accompanied with multitude of complications as cognitive, behavioral, and psychiatric disorders. Experimental studies and clinical evidence obtained in animal models of epilepsy and human brain specimen from various drug-resistant forms of epilepsy show the activation of the innate and adaptive immunity mechanisms and the induction of the associated inflammatory processes in the epileptogenic foci. |
REHAM I EL-MAHDY; | 2020-02-01 |
| 138 | Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double-blind randomized placebo controlled trial that will investigate whether the use of three specific species of probiotics taken orally in pregnancy from 25 weeks gestation will reduce the incidence of Group B Streptococcus (GBS) colonization. Participants will take 2 capsules and 1 lozenge per day of either probiotic or placebo from 25 weeks gestation. The primary outcome will be the study-specific vaginal/rectal swab collected after 35 weeks gestation and before delivery. A reduction in women testing positive for GBS would lead to a decrease risk to infants of GBS infection and a reduction in the use of antibiotics leading to less maternal and neonatal antibiotic exposure. |
MICHELLE BUTLER; | 2020-01-16 |
| 139 | Antifungal Treatment of Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cryptococcal meningitis (CM) is one of the leading opportunistic infections and one of the most common causes of death in AIDS patients. Amphotericin B (AmB) is the corner stone in CM treatment. The effect of AmB was dose-dependent. Recent retrospective study indicated that longer duration rather than higher dose of AmB is necessary to reduce the mortality of CM. We aimed to explore the efficacy and safety of small dose but longer duration of AmB for the treatment of HIV-associated CM. |
JUN CHEN; | 2020-01-02 |
| 140 | Pattern of Pediatric Seizures at Al-Arish Central Hospital – North Sinai PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be carried to: 1. Describe the pattern of seizures among cases admitted to Pediatric department at Al-Arish central hospital in North Sinai and compare results with national and international similar studies . 2. Provide the basic descriptive information that is necessary for planning future studies. |
EHSAN M SAIED; | 2019-12-01 |
| 141 | Comparison of The Hypotensive Efficacy of Propofol Infusion Versus Nitroglycerin Infusion in Functional Endoscopic Sinus Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Objectives: FESS is a common minimally invasive surgery that requires a clear field to be performed well. Hypotensive anesthesia is one of the most common maneuvers performed to help in keeping the field clear. An ideal drug for hypotensive anesthesia should be cheap and familial to the anesthesiologist. So being familial with propofol and by using its cardio-depressant action the idea of the research was developed and comparing it with nitroglycerin (a hypotensive agent in our protocol). Methods: The patients agreed to participate in the research were classified into two groups for comparison. Propofol group; … |
RASHA GAMAL ABUSINNA; | 2019-12-01 |
| 142 | OpTImisation of Methods for A Human INfection Model for Group B Streptococcus PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Group B Streptococcus (GBS) is the leading cause of neonatal sepsis and meningitis. In 2015, it was estimated that worldwide there were at least 320,000 infants with invasive GBS disease, 90,000 infant deaths and 10,000 cases of children with disability related to GBS meningitis. Maternal rectovaginal colonization with GBS is the biggest risk factor for neonatal GBS sepsis and meningitis within the first 6 days of life, … |
CATHERINE COSGROVE; | 2019-11-04 |
| 143 | Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed as two sequential trials. The first is a phase I open label trial to evaluate the safety and tolerability of MAT2203. The maximal tolerated and non-toxic daily dose,will then be moved forward into a multi-day safety trial. The Phase II trial will investigate toxicity and early fungicidal activity (EFA) of MAT2203 with flucytosine. |
MATINAS BIOPHARMA NANOTECHNOLOGIES | 2019-10-24 |
| 144 | Prospective Epidemiological Study to Estimate The O-serotype Distribution of Extraintestinal Pathogenic Escherichia Coli (ExPEC) Isolated From Hospitalized Patients Aged 60 Years or Older With Invasive ExPEC Disease (IED) and to Evaluate The Clinical Case Definition and Risk Factors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to collect information from study participants who are hospitalized with an invasive disease caused by Extraintestinal pathogenic E. coli (ExPEC). This information will be used to support the development of a new vaccine to prevent Extraintestinal pathogenic Escherichia coli (ExPEC). E. coli bacteria are a leading cause of serious infections. Especially adults older than 60 years have a higher risk of developing such infections. To date, there is no vaccine available to prevent E. coli infections. To support the development of a vaccine, … |
MJM BONTEN; | 2019-10-22 |
| 145 | Randomized Controlled Trial of Vitamin D Supplementation on Improvement of Pneumonic Children at Tertiary Pediatric Hospital in Egypt PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In Egypt, according to UNICEF 2018, Acute Respiratory Tract Infection (ARTIs)was estimated to account for 11% and 19% of the under-five and post-neonatal mortalities respectively. Despite the well-recognized role of vitamin D in metabolism and homeostasis in the general population, there is now growing interest in its probable association with pneumonia. Globally, about 30% to 90% of Under-5 children experience vitamin D deficiency. This could vary among children, according to the socioeconomic, environmental and behavioral circumstances. Studies evaluating the association of 1,25 (OH)2D deficiency and the severity of respiratory tract infection, are rare and showed controversial findings. However, … |
CAIRO UNIVERSITY | 2019-09-09 |
| 146 | Post-market Clinical Data Collection Plan for The Biodesign® Dural and Duraplasty Grafts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical study is to gather post-market clinical evidence on the use of the Biodesign® Dural and Duraplasty Grafts when used as a dura substitute of the dura mater. |
COOK RESEARCH | 2019-09-03 |
| 147 | Organization of Ambulatory Telemonitoring of People With Hearing Loss and Having A Cochlear Implant Related Papers Related Patents Related Grants Related Experts View Highlight: The number of patients with cochlear implants increases every year, constituting an active queue increasingly important (60 new cases per year in Toulouse, active list in 2013: 380 adult patients). The number of approved cochlear implant centers is limited by guardianships, and corresponds to the Hospitals University. It is not possible to create networks of correspondents. Teams of implantation centers must meet the needs of new patients and ensure continuity of care for patients already implanted: speech therapy monitoring, adjustment and rehabilitation. In case of malfunction of the implant, … |
OLIVIER DEGUINE; | 2019-09-01 |
| 148 | Emergency Department Triage in A Resource Constrained Setting: Application of The World Health Organization Triage Scale in Regional Papua New Guinea PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Triage is an important component of emergency care (EC). It aims to sort patients based on the urgency of their condition such that the highest acuity patients are prioritised for assessment and treatment. Grounded in the ethical principles of equity and justice, triage is necessary whenever there is a mismatch between demand for EC and the availability of resources. Globally, … |
ROB MITCHELL; | 2019-08-30 |
| 149 | Post-authorization Safety Study for Assessment of Pregnancy Outcomes in Patients Treated With Tildrakizumab PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will utilize a prospective, observational, exposure cohort design to examine pregnancy and infant outcomes in women and infants who are exposed to tildrakizumab during pregnancy to treat an approved indication. The pregnancy registry cohort study will be conducted by the Organization of Teratology Information Specialists (OTIS), … |
SUN PHARMACEUTICAL INDUSTRIES | 2019-08-29 |
| 150 | Intraoperative Ultrasound in Patients Undergoing Transsphenoidal Surgery for Pituitary Adenoma: A Prospective Devleopment Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pituitary adenoma can be difficult to cure with approximately a third of patients in contemporary series’ undergoing incomplete resection. Over the last decade or so a handful of groups have described the use intraoperative ultrasound to improve resection. Although limited, these proof-of-concept studies suggest intraoperative ultrasound is a safe and effective technological adjunct to transsphenoidal surgery for pituitary adenoma. In this prospective development study 30 adult patients will undergo transsphenoidal surgery for pituitary adenoma with prototype intraoperative ultrasound devices. The primary outcomes will be technical feasibility and device safety. The secondary outcomes will be complete versus incomplete radiological resection, … |
UNIVERSITY COLLEGE LONDON | 2019-08-07 |
| 151 | Effect of Drinking Water Chlorination on Child Survival in Rural Kenya PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to estimate the effect of community-wide provision of water treatment (chlorine) solution on all-cause child mortality and on infectious disease related child mortality. We will also examine effects on the following secondary outcomes: 7-day diarrhea prevalence, all-cause under-2 mortality, diarrheal disease related child mortality, school attendance, and school enrollment. In addition, and for a subsample of children, we will examine effects on motor development, emergent language and literacy, emergent math/numeracy, and socio-emotional development. |
AMY PICKERING; | 2019-07-26 |
| 152 | Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella Sp Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Klebsiella pneumoniae is implicated in the occurrence of severe pneumonia. Most Klebsiella pneumoniae infections are associated with care and occur in patients with compromised immune defenses. More recently, cases of hepatic abscess and acute community meningitis related to strains of Klebsiella pneumoniae have been reported. The mortality of these infections is important, most often due to a delayed diagnosis. The poor prognostic factors reported in the literature for very low numbers are: advanced age, coma, septic shock, glyceryachia <10mg / dL and proteinuria> 750 mg / dL. In addition, … |
GROUPE HOSPITALIER PARIS SAINT JOSEPH | 2019-07-05 |
| 153 | Characterization of Ceftobiprole’s Cerebrospinal Fluid Penetration in Patients With External Ventricular Derivation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Cerebrospinal fluid penetration of ceftobiprole has been studied in an animal model of meningitidis. Ceftobiprole is bactericidal, well tolerated and it has anti-biofilm activity. Altogether, these pharmacodynamics and pharmacokinetic properties of ceftobiprole are suitable for its use in case of External Ventricular Derivation(EVD)-related ventriculitis. Nowadays there are no human studies on the penetration and efficacy of ceftobiprole in the CSF. The study aims to evaluate characteristics of the CSF penetration of Ceftobiprole after intravenous administration in patients with EVD, that need for a concomitant infection this therapy (prescribed by an Infectious Diseases doctor). |
PIVA SIMONE; | 2019-07-02 |
| 154 | Benefit of Analyzing Exosomes in The Cerebrospinal Fluid During The Medical Care of Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, interventional, prospective study among breast cancer patients with a suspicion of metastatic meningitis. The current study aims to assess the use of proteomic profile issued from cerebrospinal fluid microvesicles for diagnosis of leptomeningeal metastases. |
EMILIE LE RHUN; | 2019-07-01 |
| 155 | The Accuracy of Advanced Probabilistic Diffusion Tensor Tractography (DTT) for The Pre-operative Identification of Facial Nerve Position in Patients With Extrameatal Vestibular Schwannomas PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vestibular schwannomas (VS) arise from the vestibulocochlear (hearing and balance) nerve, located at the base of the brain. Although benign, VS can enlarge over time, resulting in debilitating symptoms; therefore, surgical removal is frequently offered. One significant risk of surgery is inadvertent injury to the facial nerve, which lies adjacent to the vestibulocochlear nerve. Currently, the nerve’s course is only revealed during surgical dissection and injury can cause permanent facial weakness. It would therefore be useful for the surgeon to know the course of the nerve before operating. To this end, … |
STEVE CONNOR; | 2019-06-27 |
| 156 | Evaluation of Xpert MTB/RIF Ultra in Stools and Urine to Improve Tuberculosis Diagnosis in Children PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) diagnosis in children is challenging in low and middle-income countries where access to TB culture and X-ray is limited. More than half cases of childhood TB remain undiagnosed every year. A delay in TB diagnosis can lead to an increase in preventable morbidity and mortality. This study aims to provide evidence on the diagnostic accuracy of Xpert MTB/RIF Ultra in stools and urine for TB diagnosis in children. |
LAURA MORETÓ PLANAS; | 2019-06-26 |
| 157 | Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose is, in patients with aneurysmal subarachnoid haemorrhage in the early phase after ictus, to examine the following: 1. The effect of spontaneous and induced changes on the brain’s static and dynamic autoregulation calculated by transcranial Doppler (TCD), ICP and MAP (primary purposes) and ICP and PbtO2; 2. The effect of mild hyper- and hypocapnia as well as of mild hyper- and hypoxia on the brain’s static and dynamic autoregulation, ICP and PbtO2; 3. The relationship between brain autoregulation, mild hyper- and hypocapnia, as well as of mild hyper- … |
MARKUS HARBOE OLSEN; | 2019-06-15 |
| 158 | Phase IIA Trial of The Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid With or Without Aspirin, for HIV-associated Tuberculous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: LASER-TBM is a parallel group, randomized, multi-arm phase IIa trial evaluating the safety of increased dose rifampicin (RIF) plus linezolid (LZD), with or without aspirin (ASA), for the treatment of HIV-infected adults with tuberculous meningitis (TBM). The study will recruit 100 HIV-infected adults with TBM across four sites in South Africa. The primary endpoint is the occurrence of solicited treatment-related adverse events. Secondary endpoints include death and disability (including neurocognitive impairment), radiological outcomes, … |
ROBERT J WILKINSON; | 2019-06-12 |
| 159 | Inpatient Vs Outpatient Management of Women With Short Cervix: A Randomized Controlled Trial (RCT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The presence of short cervix during pregnancy is a risk factor for preterm birth though in many cases women will eventually deliver at term or near term. While there are proven treatments such as cerclage and progesterone that can improve pregnancy outcomes, many women are advised to limit their activity, are put on bed rest, or admitted to hospital for inpatient management. Presently, … |
ORI NEVO; | 2019-06-06 |
| 160 | An Epidemiological Survey to Establish The Spectrum of Circulating Serotypes of S. Pneumoniae, in Patients Older 18 Years: Healthy Carriage, Patients With Non-invasive and Invasive Pneumococcal Infections in The Russian Federation PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococcal conjugate vaccine was added to the National Immunization Program in Russia in 2014 which could affect the changes in pneumococcal serotypes in growing population. The purpose of this study is to determine the spectrum of serotypes of S. pneumoniae in patients older 18-years: in healthy carriage, in patients with non-invasive and invasive forms of pneumococcal infection. The patients will be divide into several groups: 18-64-years old, 65 years old and older, immunocompromised patients, … |
ROMAN KOZLOV; | 2019-06-01 |
| 161 | Zekai Tahir Burak Women’s Health Research and Education Hospital PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Meningitis, defined as inflammation of the meninges caused by different pathogens, is a serious infection associated with high morbidity and mortality. It occurs more commonly in the neonatal period than in any other age group. Neonatal meningitis is a devastating infection that occurs more commonly in neonates than in any other age group, and is associated with significant morbidity and mortality. In this study, we aimed to evaluate epidemiology, treatment and prognosis of neonatal meningitis in a large-scale retrospective multicenter cohort study. The main objectives of this study were to assess the incidence, temporal trend, risk factors, causative organisms, … |
MEHMET YEKTA ONCEL; | 2019-06-01 |
| 162 | Maternal And Neonatal Screening For Group B Streptococci in Fayoum Governrate: A Follow Up Study Related Papers Related Patents Related Grants Related Experts View Highlight: Group B Streptococcus (GBS), is a facultative gram positive diplococcus originally known for causing bovine mastitis and was not demonstrated to be a human pathogen until 1938. In the 1970s, GBS emerged as the leading cause of neonatal morbidity and mortality, with a frequency of 2-3 cases per 1,000 live births and case-fatality ratios as high as 50% |
SAHAR MY ELBARADIE; | 2019-06-01 |
| 163 | A Prospective Epidemiological Study of Pregnancy Outcomes and of Events of Interest in Pregnant Women, Neonates and Infants (PEPNI) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess pregnancy outcomes, and maternal, as well as neonatal events of interest in healthy pregnant women and their new-borns. The study will also determine incidence of lower respiratory tract illness (LRTI) caused by respiratory syncytial virus (RSV) in the new-borns during their first year of life. |
GLAXOSMITHKLINE | 2019-05-30 |
| 164 | Randomized Clinical Trial to Compare Efficacy and Safety of Repeated Courses of Rituximab to That of Maintenance Mycophenolate Mofetil Following Single Course of Rituximab in Maintaining Remission Over 24 Months Among Children With Steroid Dependent Nephrotic Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the RITURNS II study is to evaluate the efficacy and safety of Repeat courses of Rituximab to that of maintenance Mycophenolate Mofetil following single course of Rituximab in maintaining remission over 24 months among Children with Steroid Dependent Nephrotic Syndrome (SDNS). |
BISWANATH BASU; | 2019-05-15 |
| 165 | A Phase III, Open-label, Prospective, Multicenter Study to Assess Efficacy, Safety and Pharmacokinetics of Kedrion Intravenous Immunoglobulin (IVIg) 10% in Primary Immunodeficiency Disease (PID) Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to assess efficacy and safety of Kedrion Immunoglobulin 10% (KIg10) in participants with Primary Immunodeficiency (PID). |
MEDICAL DIRECTOR; | 2019-04-30 |
| 166 | Neonates and Azithromycin, An Innovation in The Treatment of Children in Burkina Faso PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Although under-5 mortality rates are declining globally, neonatal mortality remains persistently high in many regions of sub-Saharan Africa. Mass azithromycin distribution to children aged 1-59 months has been shown to reduce childhood mortality in Niger, Tanzania, and Malawi. This study did not evaluate the effect of azithromycin administered during the neonatal period. Observational evidence from high income countries has suggested that macrolides, including erythromycin and azithromycin, may be associated with increased risk of development of infantile hypertrophic pyloric stenosis (IHPS). However, these studies are limited by confounding by indication, … |
CATHERINE E OLDENBURG; | 2019-04-11 |
| 167 | Impact of An Early Out-of-bed Paradigm in Postoperative Outcomes of Chronic Subdural Hematomas: GET-UP Randomized Prospective Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Compare rates of medical complications, recurrence and outcome in 2 randomized groups of patients with surgical chronic subdural hematomas. The intervention group will be assigned to early mobilization (within 12 hours of the surgical procedure). The control group will be assigned to bed rest for 48 hours. |
SÉRGIO SOUSA; | 2019-04-07 |
| 168 | Clinical Evaluation of The FilmArray® Meningitis/Encephalitis (ME) Panel PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The FilmArray Meningitis/Encephalitis (ME) Panel (hereinafter referred to as FilmArray ME Panel) is a qualitative multiplexed nucleic acid-based in vitro diagnostic test intended for use with FilmArray systems. The FilmArray ME Panel is capable of simultaneous detection and identification of multiple bacterial, viral, and yeast nucleic acids directly from cerebrospinal fluid (CSF) specimens obtained via lumbar puncture from individuals with signs and/or symptoms of meningitis and/or encephalitis. |
CAO QING; | 2019-04-01 |
| 169 | Paediatric Infections Point-Of-Care: Point-of-care Approach for Rapid and Easy Meningitis Diagnosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to identify the aetiology of childhood meningitis in Southwestern Uganda and develop and evaluate new methods for point-of-care diagnosis of childhood meningitis in a low-income setting. A prospective observational study including 600 children aged 0-12 years will be conducted during 1 year in Mbarara, Uganda. We estimate to recruit about 300 children with suspected meningitis (cases), and 300 with non-severe infection age-matched as controls. |
TOBIAS ALFVÉN; | 2019-04-01 |
| 170 | Phase 3 Study of BK1310 Compared With ActHIB® and Tetrabik in Healthy Infants: A Randomized, Assessor-blind, Active-controlled PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate immunogenicity of BK1310 for all antigens (anti-PRP, diphtheria toxin, pertussis, tetanus toxin, and polio virus), after 3 times of injection, when compared noninferiority with co-administration of ActHIB® and Tetrabik, as well as efficacy and safety, in healthy infants. |
MITSUBISHI TANABE PHARMA | 2019-04-01 |
| 171 | A Phase 2, Randomized, Double Blind, Placebo , Controlled Study To Evaluate The Administration of CN-105 In Participants With Acute Supratentorial Intracerebral Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase 2, randomized, double-blind, placebo controlled study to evaluate the administration of CN-105 in patients with supratentorial intracerebral hemorrhage (ICH). Patients will be evaluated for eligibility within 12 hours of symptom onset. Eligible participants (30 active participants and 30 control participants) will receive CN-105 or placebo administered intravenously (IV) for a 30-minute infusion every 6 hours for up to a maximum of 3 days (13 doses) or until discharge (if earlier than 3 days). Participants will be monitored daily throughout the Treatment phase of the study (up to a maximum of 5 days) and will receive standard-of-care treatment for the duration of the study. Additional protocol assessments will be required during the Treatment phase as outlined in Section 7.5. After discharge from the hospital, participants will enter a 3-month Follow-up phase, with a clinic visit at 30 days and a follow-up telephone interview with telephone-validated mRS at 90 days after first dose of study agent. |
NATIONAL NEUROSCIENCE INSTITUTE | 2019-03-24 |
| 172 | A Prospective Study to Evaluate The Safety, Effectiveness and Impact of The RTS, S/AS01E Vaccine in Young Children in Sub-Saharan Africa PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The RTS, S/AS01E vaccine was developed to protect children in sub-Saharan Africa from malaria as part of routine immunization programs. This study aims to check the vaccine’s safety after it has been introduced. Along with safety, researchers will also assess how well the vaccine works and its overall impact on children’s health. |
KWAKU POKU ASANTE; | 2019-03-21 |
| 173 | Immunisation Status Against Major Communicable Diseases Preventable With Vaccines, and Safety of Vaccines, in A Cohort of MS Patients. An Italian Multicenter Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Multiple sclerosis (MS) patients are more susceptible to infections than the general population in relation to some specific therapies or increasing disability. Clearly, the use of immuno-suppressant/modulatory drugs requires particular attention to the occurrence of infectious events. In this perspective, among still unmet clinical needs in MS patients is a comprehensive picture on the immunisation status against infectious diseases, especially those preventable with vaccines. Despite of the relevance of vaccinations, there are still some concerns about their utilization in MS patients. In literature, … |
MONICA ULIVELLI; | 2019-03-20 |
| 174 | Repeating A Lumbar Puncture at 24 Hours Versus 48 Hours After A Macro-traumatic Lumbar Puncture in Newborn Infants: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Visibly traumatic as well as microtraumatic lumbar punctures (LP) are very common in the neonatal period. The presence of blood makes it difficult to interpret cerebro-spinal fluid (CSF) findings. Clinicians often perform a repeat LP in the hope that some of the red blood cells would have cleared by then, allowing a better interpretation of the CSF findings. There is no published information whether a repeat LP provides any added information to the original traumatic LP, and if so what is the best time to repeat an LP after a traumatic LP. In this randomised controlled trial (RCT), … |
SOURABH DUTTA; | 2019-03-18 |
| 175 | Clinical and Microbiological Analyses of Infections Following NeuroSurgery: A Retrospective, Single-center Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Neurosurgery (NS) is essential for the treatment of various diseases such as malignant tumors, vascular conditions, spinal stenosis or trauma. However, NS can be complicated by the onset of infections, directly related to surgery or to hospitalization. Little is known regarding the epidemiology, the optimal treatment regimens and the outcome of infections following NS (I-NS). The study aims at investigating the clinical and microbiological characteristics as well as the outcomes of I-NS occurring at a single Institution (IRCCS Neuromed, Pozzilli, … |
ALESSANDRA OLIVA; | 2019-03-11 |
| 176 | Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis Based on N-Acetyltransferase Type 2 Genotyping PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The genetically polymorphic N-acetyltransferase type 2 (NAT2) is responsible for isoniazid metabolism, and rapid acetylators were associated with low concentrations of isoniazid based on previous studies. The investigators hypothesize that among rapid acetylators high dose isoniazid would result in lower rates of death and disability in patients with tuberculous meningitis than the rates with the standard regimen. The investigators recruited patients between the ages of 18 and 65 years with newly diagnosed TBM, then NAT2 genotype will be characterized by using High-Resolution Melting Kit (Zeesan Company, … |
HONGFEI DUAN; | 2019-03-04 |
| 177 | Assessment of The Different Etiological and Susceptibility Markers in Patients With Pancreatitis: Investigating IG4, Cytomegalovirus, Coxsackie- Virus, Genetic Polymorphism of Vitamin D Receptor Gene PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute pancreatitis (AP) is a multifactorial disease. AP represents a significant number of hospital admissions. Most of the patients are admitted in an acute setting. Early identification of its etiology is an essential step toward the rational approach, both for its implications in the immediate therapy and the prevention of recurrence. Although often obvious, the etiological workup of acute pancreatitis can be challenging. |
REHAM I EL-MAHDY; | 2019-03-01 |
| 178 | Cluster-randomized Trial to Evaluate The Impact of Ciprofloxacin Prophylaxis As A Response to A Meningococcal Meningitis Epidemic Related Papers Related Patents Related Grants Related Experts View Highlight: The trial is an interventional, cluster-randomized trial to assess the impact of oral ciprofloxacin for household and community contacts of meningitis cases on the incidence of meningitis during an epidemic. The trial contains a nested sub-study (resistance study) to assess the effect of a single dose of ciprofloxacin on the prevalence of fluoroquinolone-resistant enterobacteriaceae in the study area. |
EPICENTRE | 2019-03-01 |
| 179 | Infections of The Central Nervous System – An Observational Cohort Study Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to describe the incidence of infectious meningitis and/or encephalitis, and to analyze clinical, diagnostic and treatment characteristics of patients with suspected (and subsequently verified and not verified) infection. |
RAOUL SUTTER; | 2019-03-01 |
| 180 | An Evaluation of The Pilot Implementation of RTS,S/AS01 Through Routine Health Systems in Moderate to High Malaria Transmission Settings in Africa PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The RTS,S/AS01 malaria vaccine is being introduced sub-nationally in phased pilot introductions through the EPI programmes in Malawi Ghana and Kenya. Vaccine introduction is by the respective MoH in selected areas randomly assigned to receive the vaccine at the beginning of the pilots. In the context of this programmatic activity, the Malaria Vaccine Pilot Evaluation (MVPE) registered here as observational evaluations during early vaccine introduction, include a series of 3 household surveys, and sentinel hospital and community mortality surveillance, building on routine systems. These observational evaluations will measure: 1. The programmatic feasibility of delivering a 4 dose schedule; … |
PATRICIA NJUGUNA; | 2019-02-25 |
| 181 | A Randomized Study to Determine The Efficacy of A Multi-tiered Community- and School-based Approach to Enhance School-aged Children’s Recommended Vaccinations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to understand how improving vaccine education and awareness can impact the number of parents who vaccinate, or intend to vaccine, their middle school-aged children with age-appropriate vaccines, including human papillomavirus (HPV), meningitis (MCV) and tetanus, diphtheria, pertussis (TDap). |
JENNIFER KRASCHNEWSKI; | 2019-02-14 |
| 182 | Urine and CRP Tests at The Point-of-care for The Diagnostic Assessment of Acutely Ill Children: A Diagnostic and Prognostic Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the accuracy of a novel urine test for diagnosing urinary tract infections in acutely ill children presenting to ambulatory care. The accuracy of this novel test will be compared to the accuracy of conventional dipstick testing. In addition, the evidence on urine tests will be added to the existing algorithm for diagnosing serious infections in children. Finally, the study aims to describe the relation between the CRP level at study entry and the duration of symptoms and final diagnosis over the following 30 days. |
ANN VAN DEN BRUEL; | 2019-02-12 |
| 183 | Comparison of Immunofluorescence Assay (IFA) and Chemiluminiscence Immunoassay (LIAISON®) for Diagnosis of Early Disseminated Lyme Borreliosis in Children, Younger Than 18 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to compare two different serological tests, IFA and LIAISON, for detection of Borrelia burgdorferi sensu lato IgM and IgG antibiodies in children with early disseminated Lyme borreliosis. |
MAJA ARNEZ; | 2019-01-29 |
| 184 | Anlotinib Plus Platinum-etoposide in First-line Treatment of Extensive-stage Small-cell Lung Cancer: A Single-arm Phase II Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anlotinib is a novel multi-target tyrosine kinase inhibitor (TKI) for tumor angiogenesis and tumor cell proliferation. The efficacy of Anlotinib as a third-line or beyond therapy for SCLC was confirmed in the ALTER1202 trial. The aim of this trial was to investigate the prognostic value of Anlotinib plus platinum-etoposide in first-line treatment of extensive-stage SCLC patients. |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2019-01-24 |
| 185 | A Phase I Clinical Trial to Compare The Safety and Immunogenicity of Candidate TB Vaccine ChAdOx1 85A Administered By The Aerosol Inhaled Route and The Intramuscular Route in Healthy Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a dose escalating and a paired-placebo design study to describe the safety and immunogenicity profile of candidate TB vaccine ChAdOx1 85A given by aerosol inhaled vaccination versus intramuscular (IM) vaccination in adult healthy volunteers. It is postulated that the aerosol inhaled route is practical and feasible and has an acceptable safety profile, comparable to the systemic safety profile of the IM route of administration of ChAdOx1 85A in adult healthy volunteers, … |
FRANÇOIS SPERTINI; | 2019-01-22 |
| 186 | Comparison of The Efficacy of A 7-day Versus 14-day Course of Intravenous Antibiotics in The Treatment of Uncomplicated Neonatal Bacterial Sepsis: A Randomized Controlled Non-inferiority Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The optimum duration of intravenous antibiotic therapy for culture-proven neonatal bacterial sepsis is not known. Current practices, ranging from 7 days to 14 days of antibiotics, are not evidence-based. This is a randomized, active -controlled, multi-centric, non-inferiority trial to compare the efficacy of a 7-day course of intravenous antibiotics versus a 14-day course among neonates weighing > 1000 g at birth with culture-proven bacterial sepsis that is uncomplicated by meningitis, bone or joint infections deep-seated abscesses. The primary outcome measure is a definite or probable relapse within 21 days after stoppage of antibiotics. |
SOURABH DUTTA; | 2019-01-01 |
| 187 | Propolis As A Treatment Option for Hand Foot and Mouth Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hand foot and mouth disease (HFMD) is a frequently self-limited viral infectious disease in children with no specific antiviral treatment option. There has been an increasing interest in bee products in recent years, and propolis has come to the fore with its high therapeutic and protective effect. Although the inhibitory effect of propolis against enteroviruses (EVs) has been shown in studies, … |
MURAT SUTCU; | 2019-01-01 |
| 188 | Evaluation of Different Methods for Rapid Diagnosis of Meningitis in Assiut University Hospital Related Papers Related Patents Related Grants Related Experts View Highlight: Bacterial meningitis occurs in about 3 people per 100,000 annually in Western countries. . |
DOHA FAHMY; | 2019-01-01 |
| 189 | Maternal Immunization With MenAfriVac™ PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The World Health Organization (WHO) recommends that infants receive a single dose of the meningococcal serogroup A-tetanus toxoid conjugate vaccine, MenAfriVac, when they reach at least 9 months of age. However, this leaves a window of susceptibility in early life when the incidence of invasive serogroup A disease, … |
ED CLARKE; | 2018-12-19 |
| 190 | Is Lidocaine Really Guilty? A Prospective, Randomized, Double Blind Comparison of The Incidence of TNS After Intrathecal Lidocaine Administration Vs. Intrathecal Bupivacaine in Patients Undergoing Spinal Anesthesia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look into the incidence of Transient neurological symptoms (TNS) after the intrathecal use of lidocaine in comparison to intrathecal Bupivacaine. |
JF ASENJO; | 2018-11-01 |
| 191 | Comparison of Constraint-induced Movement Therapy and Its Modified Form on Upper Motor Function Outcomes and Psychosocial Impact in Hemiplegic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research is to compare the effect of classic constraint-induced movement therapy and its modified form on upper extremity motor function outcomes and psychosocial impact in hemiplegic cerebral palsy. Randomized controlled trials with 2-3 weeks follow-up. The sample size is 40. The subjects are divided in two groups, 20 subjects in classical CIMT group and 20 in modified CIMT group. Study duration is of 6 months. Sampling technique applied will be purposive non probability sampling technique. Only 4-12 years individual with hemiplegic cerebral palsy are included. Tools used in the study are Box and Block test, … |
IMRAN AMJAD; | 2018-10-15 |
| 192 | Adherence to Anti-infectious Treatment Protocols in Emergencies and Short-term Hospitalization at The Infectious Disease Department PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Consensual antibiotic protocols have been developed and validated locally by infectious disease specialists, internists and emergency physicians, in order to encourage their compliance. A preliminary study was conducted from June 2015 to February 2016, including 622 patients admitted to the emergency department for infectious syndrome such as / – Pneumoniae – Urinary tract infection – Cellulitis – Meningitis – Malaria – Febrile neutropenia – Febrile acute diarrhea – Fever back to the tropics – Angina – … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2018-09-01 |
| 193 | Outcome Predictors of Non Traumatic Coma in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To catch the high risk comatosed child to improve service and direct the limited resources to those children in countries with limited resources . |
HANAN ZAKA SAIED; | 2018-09-01 |
| 194 | Increasing Healthcare Engagement Via Routine Vaccination Among Young Black Men Who Have Sex With Men Related Papers Related Patents Related Grants Related Experts View Highlight: Vaccine-preventable diseases such as hepatitis A and meningitis, as well as cancers caused by human papillomavirus (HPV) disproportionately impact young Black men who have sex with men (YBMSM). Traditional techniques of vaccination promotion have been unable to address the racial disparities in vaccination rates. One promising method for influencing behavior change within YBMSM networks is diffusion of information through Popular Opinion Leaders (POLs). The POL model engages persons who are leaders within their own networks/communities to promote behavior change. The objective of this project is to develop and pilot test a POL intervention to increase routine HAV, … |
AMY K JOHNSON; | 2018-09-01 |
| 195 | Intravenous and Intraperitoneal Lignocaine for Perioperative Analgesia in Laparoscopic Colon Resections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the analgesic effects of intraperitoneal lignocaine (IPL) compared with intravenous lignocaine (IVL) after laparoscopic colon resections. We plan to run a 2 group randomized, double blind, clinical trial which will look into morphine consumption as the primary outcome. Group 1 (IV lignocaine)- IV bolus of lignocaine and a 3 day post operative IV lignocaine infusion. Intra peritoneal (IP) bolus of normal saline + 3 day post operative IP normal saline infusion Group 2 (IP lignocaine)- … |
ANDREW G HILL; | 2018-08-17 |
| 196 | Application of Image Guidance Technology to Bedside External Ventricular Drain Placement PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: External ventricular drain (EVD) placement is performed very often in neurosurgical practices. EVD’s are most commonly placed at the bedside using external anatomical landmarks to guide the catheter into the frontal horn of the ipsilateral lateral ventricle. EVDs are often placed due to acute neurological compromise and require timely insertion. Accurate catheter placement is essential to achieving effective external CSF drainage without complications or occlusion/failure of the catheter. Catheter placement is most commonly performed via a freehand approach using external anatomical landmarks to help identify the location of the lateral ventricle within the brain without the aid of imaging. Proper identification of the ventricles on pre-procedure imaging, surgeon skill, and estimation of pathologic perturbations to the normal location of the ventricles all factor into the success of catheter placement. Multiple passes are often required. The accuracy rate from the freehand technique has been reported to range from 40 to 98 percent. Current methods for EVD placement do not compensate for superficial brain vessels or pathology that may alter the intracranial anatomy such as trauma, hemorrhage, or mass lesions. Some studies have attempted to use CTA imaging to identify intracranial vessels in an attempt to avoid them during placement. Image guidance is a tool used very commonly for placement of EVD’s and shunts in the operating room. AxiEM Stealth is a noninvasive image localization modality that registers a CT or MRI to the individual patients facial and scalp anatomy. This study will compare the current standard of care of freehand placement of bedside external ventricular catheters to the placement of EVD catheters with AxiEM Stealth image guidance. |
AZAM AHMED; | 2018-08-15 |
| 197 | A Multicenter Double Blinded Randomized Controlled Trial of The Efficacy of The Sphenopalatine Ganglion Block for The Treatment of The Postdural Puncture Headache After Labor Epidural Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess the effectiveness of the SPG block with lidocaine vs. SPG block with placebo on preventing the need for EBP in women who develop PDPH after accidental dural puncture during placement of LEA for labor. |
UNIVERSITY OF UTAH | 2018-07-01 |
| 198 | Adjunction of Daptomycin for The Treatment of Pneumococcal Meningitis: AddaMAP Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococcal meningitis is an infection of the membrane that covers the brain. It is a serious infection which is currently treated with a combination of corticosteroids (dexamethasone) and 3rd generation cephalosporins. Nevertheless, complications associated with meningitis are relatively frequent and severe. Recent animal studies have shown that another antibiotic, daptomycin, can reduce the mortality and long-term effects of pneumococcal meningitis. Daptomycin is widely used worldwide in humans for other diseases, with few side effects. This study aims to evaluate the effect of daptomycin on the proliferation of the bacterial infection, … |
CENTRE HOSPITALIER UNIVERSITAIRE DIJON | 2018-06-07 |
| 199 | Oral Probiotics to Reduce Vaginal Group B Streptococcal Colonization in Late Pregnancy: A Randomized Placebo-controlled Double-blinded Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In the present study, the investigators aim to evaluate the potential of oral probiotics, containing Lactobacillus strains, to eradicate and reduce the vaginal colonization with group B Streptococcus (GBS) during pregnancy. This could help to prevent neonatal morbidity and mortality by reducing the risk for neonatal sepsis, pneumonia, and meningitis, known as early-onset or late-onset GBS infection. |
ALEX FARR; | 2018-06-01 |
| 200 | Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana: A Clinical and Environmental Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hospitals in the French West Indies (Fort-de-France (Martinique); Basse-Terre and Pointe-à-Pitre (Guadeloupe); and French Guiana (Cayenne, Saint-Laurent du Maroni)) have noted the emergence of eosinophilic meningitis cases in recent years. This finding is part os eosinophilic meningitis cases emergence and meningoencephalitis caused by the parasite Angiostrongylus cantonensis on the American continent and in the Greater Antilles. In 2013, the investigation of an eosinophilic meningitis case by the Basse-Terre hospital team with a positive specific PCR in the CSF (CDC, Atlanta, … |
NICOLE DESBOIS; | 2018-04-03 |
| 201 | A Observational Study on Ventilator-associated Pneumonia As A Risk for Nosocomial Infection in Mechanically Ventilated Neonates In NICU of Assiut University Children Hospital PROTOCOL OF THESIS Descriptive Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Abstract Background: Neonatal ventilator associated pneumonia (VAP) is a major hospital-acquired infection in acute care settings, associated with high mortality and poor outcome. VAP is considered a preventable infection if the risk factors are managed effectively. The purpose of this study is to evaluate prevalence of ventilator associated pneumonia, its causative organisms, its risk factors and outcome at our NICU. This study used CDC guidelines for infant’s ≤1 year old to diagnose neonatal VAP, in period from April 2018 to March 2019. |
ABD ELRHMAN FAWZY; | 2018-04-01 |
| 202 | Open and Exploratory Trial to Investigate The Pharmacokinetic of Ceftobiprole Medocaril in Patients With CSF Device Related Papers Related Patents Related Grants Related Experts View Highlight: Ceftobiprole is a very active new cephalosporin on staphylococci resistant to methicillin (SEMR: Staphylococcus epidermidis Resistant to Meticillin, SAMR: Staphylococcus aureus Resistant to Meticillin) and / or vancomycin; it is also very active on pneumococci resistant to penicillin and / or 3rd generation cephalosporins. This new drug has AMM in nosocomial respiratory infections, Animal work shows the efficacy of ceftobiprole in gram negative bacillus meningeal infections. The rationale of this study is based on the antibacterial spectrum of ceftobiprole, … |
CENTRE HOSPITALIER UNIVERSITAIRE DIJON | 2018-03-29 |
| 203 | Tolerability and Acceptability of Fibersol-2 (Resistant Maltodextrin) in Healthy and Diarrheal Children Followed By A Randomized Clinical Trial to Evaluate The Efficacy of Fibersol-2 in Diarrheal Children 1-3 Years Old PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dietary fiber, a non-digestible carbohydrate, used in decades for the beneficial effect on health with physiological importance because such compounds have low energy values. These indigestible carbohydrates generally reach the large intestine undigested and unabsorbed, they are often used in many functional and/or low-calorie food and beverages. Researchers have stated that dietary fiber especially digestive-resistant maltodextrin has innumerable beneficial effects on human health, such as improving intestinal regularity by increasing fecal bulk, stimulating peristalsis and shortening gastrointestinal transit time. Resistant maltodextrin (Fibersol-2) is a low viscosity, water-soluble, indigestible dextrin produced by the treatment of corn starch with acid, enzymes, … |
MOHAMMOD JO CHISTI; | 2018-03-19 |
| 204 | A Study to Assess The Carriage of Pneumococci in Children Aged ≤8 Years, and Their Household Contacts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Since the introduction of pneumococcal conjugate vaccines, this research group has conducted several carriage studies. These were at key points in the evolution of the pneumococcal immunisation schedule, with regard to the introduction of PCV7, the change to PCV13 and the impending change in number of doses of PCV13 given to infants. The last carriage study, conducted in 2015/16 identified interesting changes in carriage patterns which will further be explored by the current planned study. Nasopharyngeal swabs and saliva swabs will be taken from healthy subjects and any pneumococci present will be cultured and serotyped using standard methods, … |
PUBLIC HEALTH ENGLAND | 2018-02-14 |
| 205 | A Randomized Double Blind Placebo Controlled Non-inferiority Trial of Adjunctive Dexamethasone for The Treatment of HIV-uninfected Adults With Tuberculous Meningitis Stratified By Leukotriene A4 Hydrolase Genotype PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone’s clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment of TBM. The investigators will conduct a LTA4H genotype stratified, parallel group, randomised, double blind, placebo-controlled multi-centre Phase III non-inferiority trial evaluating dexamethasone versus placebo for 6-8 weeks in addition to standard anti-tuberculosis drugs. The investigators will take a hybrid trial-design approach which assumes a modest harm of dexamethasone and aims to prove non-inferiority of placebo first but also allows claiming superiority of placebo in case dexamethasone causes substantial harm. Moreover, … |
GUY THWAITES; | 2018-02-08 |
| 206 | Application of Next Generation Sequencing Technique in Pediatric Bacterial Meningitis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Pathogen identification is of paramount importance for bacterial meningitis. At present, the pathogen of bacterial meningitis is still mainly based on Gram stain and bacterial culture. However, cerebrospinal fluid (CSF) culture can be negative in children who receive antibiotic treatment prior to CSF examination.Because of the limitations of clinical laboratory testing, … |
GANG LIU; | 2018-02-01 |
| 207 | A Prospective Pharmacokinetic Evaluation of The Plasma and Cerebrospinal Fluid Concentrations of A Single Dose Ceftolozane/Tazobactam in Infected Critically Ill Patients With An Indwelling External Ventricular Drain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ceftolozane/tazobactam is an emerging newly available antibiotic that has a broad spectrum of activity, and could be potentially useful in the management of central nervous system infections. However, data relating to penetration of ceftolozane/ tazobactam into the central nervous system, where a barrier against drug distribution exists (i.e. blood brain barrier), … |
JASON ROBERTS; | 2018-02-01 |
| 208 | Retrospective Real-word Study of Linezolid for The Treatment of Tuberculous Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculous meningitis (TBM) is the most serious form of Mycobacterium tuberculosis infection, causing mortality and disability in more than half of the patients. Current standard treatment for TBM is based on those developed to treat pulmonary tuberculosis, which does not take into account the differential ability of anti-tuberculosis drugs to penetrate the brain. With both good central nervous system penetrance and anti-tuberculosis efficacy that have been demonstrated in drug-resistant tuberculosis, linezolid may be a promising antimicrobial in TBM treatment. The purpose of this study is to evaluate the effectiveness of linezolid in the treatment of TBM. |
WEN-HONG ZHANG; | 2018-01-01 |
| 209 | Epidemiology of Neonatal Sepsis in Infants Admitted to Neonatal Intensive Care Unit in Assiut University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Neonatal sepsis is an important cause of morbidity and mortality in the pediatric age group . It is one of the leading causes of death in the first 28 days of life both in the developed and developing countries. |
ASSIUT UNIVERSITY | 2018-01-01 |
| 210 | Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Endonasal endoscopic approach to the skull base has been expanded in the last several years owing to advances in the radiological aspect that provided a better evaluation of the lesions and the surrounding structures, technological advances that include angled endoscope, development of high-resolution cameras, … |
AHMED GAMAL SHOLKAMY; | 2018-01-01 |
| 211 | Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Meningitis is one of the major lethal infectious diseases especially for the children in developing countries .It is not always possible and often very difficult to distinguish between bacterial and viral meningitis according to CSF findings, which is not accurate 100% and leads to unnecessary antibiotic usage , So We tried to find a useful ‘bedside’ decision-making tool, based on laboratory results readily available at the emergency department . |
MAHMOUD ABDELFATTAH; | 2018-01-01 |
| 212 | Rapid Triage for Serious Infections in Infants Younger Than 3 Months Using A Novel Heart Rate Variability Tool PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Febrile infants younger than 3 months old present a diagnostic dilemma to the emergency physician. Tension remains between the need for early aggressive intervention among patients with suspected sepsis and the global phenomena of increasing antibiotic resistance. The investigators aim to: (1) To study the association between heart rate variability (HRV) and the presence of a serious infection (SI) among infants younger than 3 months old. The investigators hypothesize that a reduced HRV is associated with the presence of SI. (2) To compare HRV between febrile infants < 3 months with non-febrile infants. The investigators hypothesize that the variability will be reduced in febrile infants with SIs when compared to non-febrile well infants, but not among febrile infants without SIs when compared to non-febrile well infants. (3) To study if HRV will provide incremental diagnostic information over current triage tools. |
KK WOMEN’S AND CHILDREN’S HOSPITAL | 2017-12-11 |
| 213 | A Multicenter Prospective Cohort Study on Neonatal Bacterial Meningitis PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Neonatal bacterial meningitis (BM) is a devastating infection that occurs more commonly in neonates than in any other age group, and is associated with significant morbidity and mortality, especially in developing countries. In this study, we aimed to develop a clinical risk score model, according to the available clinical syndromes and commonly laboratory tests, for screening BM among full-term neonates in a large-scale retrospective cohort, and prospectively validated the risk score in multicenter cohort. |
XINHUA HOSPITAL SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE | 2017-12-01 |
| 214 | CNS Infections Effect on The Inner Ear PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Study on patients with CNS infections. |
ELISA SKOVGAARD JENSEN; | 2017-12-01 |
| 215 | Atosiban Versus Placebo in The Treatment of Late Threatened Preterm Birth PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate if tocolysis with atosiban in late preterm birth (30 to 34 weeks) is (cost-) effective compared with placebo in improving neonatal morbidity and mortality. |
M.A. OUDIJK; | 2017-12-01 |
| 216 | Cryptococcal Antigen Screening Plus Sertraline PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cryptococcal meningitis or Crypto is a life threatening fungal infection around the brain that requires hospitalization for treatment for 14 days and then continued therapy. Crypto causes 15-20% of HIV/AIDS-related deaths worldwide. However, this infection can be detected before one develops symptoms and becomes ill. People can be screened for infection by a blood test to detect cryptococcal antigen, (called CrAg), which is part of the fungus, in blood. The World Health Organization and over 22 countries worldwide recommend CrAg screening of all persons with advanced AIDS entering or re-entering into HIV care. However, … |
UNIVERSITY OF MINNESOTA | 2017-11-15 |
| 217 | Epidemiology and Prognosis of Encephalitis in Intensive Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Acute encephalitis (AE) is a severe neurological disorder associated with significant morbidity and mortality. Approximately 50% of patients with AE require ICU admission because of coma, seizures or acute respiratory failure. Determinants of neurological prognosis in these patients are not known. Objectives: Main objective: To identify determinants of outcome in adult patients admitted to the ICU; Secondary objectives: a) To study the impact of diagnostic studies (Brain MRI, CSF analysis, EEG) on neurologic outcome; b) to describe the epidemiology of patients admitted to the ICU with AE; c) to study the impact of early appropriate therapy on neurologic outcomes; … |
ROMAIN SONNEVILLE; | 2017-10-27 |
| 218 | Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis and Death: A Phase III Double-blind Randomized Clinical Trial PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Though maternal and neonatal health are high priority areas for international development, maternal and neonatal mortality remain unacceptably high. Worldwide there are 1 million maternal and 4 million neonatal deaths every year and half of them occur in sub-Saharan Africa. Post-partum and neonatal severe bacterial infections, namely sepsis, are leading causes of maternal and neonatal deaths in sub-Saharan Africa. Newborns can be infected during labour – when passing through the birth canal – and also during the first days/weeks of life, as a consequence of the close physical contact with the mother, … |
ANNA ROCA; | 2017-10-21 |
| 219 | A Randomized Trial of Tamoxifen Combined With Amphotericin B and Fluconazole for Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop initial efficacy, feasibility, and safety data regarding the use of Tamoxifen in combination with amphotericin B and fluconazole in the treatment of cryptococcal meningitis. The results of the study will inform the design and feasibility of a larger study powered to a survival endpoint. The study hypothesis is that adding tamoxifen to standard antifungal therapy increases the rate of clearance of yeast from cerebrospinal fluid. Increased rates of clearance of yeast from cerebrospinal fluid have previously been associated with improved clinical outcomes, including survival and disability. |
JEREMY DAY; | 2017-10-10 |
| 220 | A Phase 1b Study of ASP8374, An Immune Checkpoint Inhibitor, As A Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to evaluate the tolerability and safety profile of ASP8374 when administered as a single agent and in combination with pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumor malignancies. Also primary purpose is to characterize the pharmacokinetic profile of ASP8374 when administered as a single agent and in combination with pembrolizumab. Last primary purpose of this study is to determine the recommended Phase 2 dose (RP2D) of ASP8374 when administered as a single agent and in combination with pembrolizumab. The secondary purpose of this study is to evaluate the anti-tumor effect (objective response rate \[ORR\], duration of response \[DOR\], persistence of response after discontinuation, and disease control rate \[DCR\]) of ASP8374 when administered as a single agent and in combination with pembrolizumab. NTP: Neutropenia NHAE:Non-haematological AE GBS: Guillain-Barré syndrome IRR: Infusion-related reaction AST: Aspartate aminotransferase ALT: Alanine aminotransferase MS/MG: Myasthenia Syndrome/Myasthenia Gravis TRT: Treatment-related Toxicity TCP: Thrombocytopenia |
ASTELLAS PHARMA GLOBAL DEVELOPMENT | 2017-09-08 |
| 221 | Single-center Phase 2 Open-label Trial Evaluating Efficacy and Safety of Daratumumab in Treatment of Patients With Proliferative Glomerulonephritis With Monoclonal Immune Deposits and C3 Glomerulopathy Associated With Monoclonal Gammopathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to see if daratumumab is safe and effective in the treatment of proliferative glomerulonephritis with monoclonal immune deposits (PGNMID) and C3 glomerulopathy associated with monoclonal gammopathy (C3GN). This is an inflammatory disease in the kidney due to the production of abnormal proteins. There are no known standard effective treatments for patients with PGNMID and C3GN secondary to monoclonal gammopathy. These diseases are caused by abnormal production of proteins (monoclonals) by abnormal clones. Daratumamb has been shown to be effective in treating patients with multiple myeloma a disease which also caused by over production of monoclonal proteins from abnormal clones. Everyone in this study will receive daratumumab. |
FERNANDO FERVENZA; | 2017-09-07 |
| 222 | A Randomized Observer-blinded Controlled Non-inferiority Trial to Evaluate The Immunogenicity of Locally Manufactured Meningococcal ACWY Vaccine ‘Ingovax ACWY’ in Bangladeshi Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be a randomized observer -blinded controlled non-inferiority study to evaluate and compare the immunogenicity of locally produced Ingovax ACWY with Quadri Meningo on a total of 88 healthy adult participants (18-45 years of age). 44 participants will receive locally produced Ingovax ACWY and 44 participants of comparator groups will receive Quadri Meningo which is produced by BiO-MeD Private Limited. Vaccination will be done in Day 0 following the screening and pre-immunization blood sample collection and post-immunization blood will be collected at Study Day 30. Follow- … |
INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH | 2017-08-21 |
| 223 | Treatment of Non-severe Community Acquired Pneumonia With Twice Daily Compared to Thrice Daily Regimen- A Non-inferiority Pragmatic Randomized-controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study will be to evaluate whether a twice-daily antibiotic regimen is non-inferior to a thrice-daily regimen for the treatment of non-severe community acquired pneumonia in children presenting at a paediatric Emergency Department (ED). |
JOCELYN GRAVEL; | 2017-06-11 |
| 224 | Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome. The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016). The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, … |
UNIVERSITY HOSPITAL MONTPELLIER | 2017-06-01 |
| 225 | A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for The Treatment of HIV-infected Adults With Tuberculous Meningitis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will conduct a randomized, double blind, placebo controlled trial of adjunctive dexamethasone in the initial (6-8 weeks) treatment of tuberculous meningitis in Vietnamese adults. The trial will address a primary hypothesis in all enrolled patients, … |
GUY THWAITES; | 2017-05-25 |
| 226 | Cluster-randomized Trial to Evaluate The Impact of Ciprofloxacin for Contacts of Cases of Meningococcal Meningitis As An Epidemic Response PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the effect of antibiotic prophylaxis with ciprofloxacin, given to the contacts of meningitis cases, on the overall attack rate of meningitis during an epidemic. One third of enrolled villages will receive standard care; in one-third of villages, household contacts of meningitis cases will be offered a single dose of oral ciprofloxacin; and in one-third of villages, the entire village will be offered a single dose of oral ciprofloxacin after the notification of the first case in the village. |
EPICENTRE | 2017-04-22 |
| 227 | The Effectiveness of Video Discharge Instructions for Acute Otitis Media on Knowledge Acquisition and Clinical Outcomes: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Thorough, understandable discharge instructions empower caregivers, allowing them to provide optimum care of their children during illness. Unfortunately discharge instructions are often incomplete and difficult to understand. The use of video discharge instructions has been shown to increase patient understanding of their illness. The investigators would like to know if using video discharge instructions for caregivers of children with middle ear infections helps to better understand how to take care of children at home, … |
NAVEEN POONAI; | 2017-03-20 |
| 228 | Clinical Phase 3 Study to Evaluate The Efficacy, Tolerability and Safety of Subcutaneous Human Immunoglobulin (Octanorm) in Patients With Primary Immunodeficiency Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinical phase 3 study to evaluate the efficacy, tolerability and safety of subcutaneous human immunoglobulin (octanorm) in patients with primary immunodeficiency diseases. |
OCTAPHARMA | 2017-03-07 |
| 229 | Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastasis From Non-small Cell Lung Cancer: A Prospective Pilot Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It has been proved that intrathecal chemotherapy is the main treatment strategy for leptomeningeal metastases. At present, the commonly used drugs for intrathecal chemotherapy include methotrexate, cytarabine, and liposomal cytarabine. In recent decades, no new effective drugs have been discovered for intrathecal chemotherapy. The recurrence of leptomeningeal metastases is inevitable even after aggressive treatment. There is no effective treatment for recurrent leptomeningeal metastases after comprehensive treatment which includes intrathecal methotrexate and/or cytarabine, central nervous system radiation therapy, systemic chemotherapy as well as tyrosine-kinase inhibitor drugs. The quality of life is extremely poor, … |
ZHENYU PAN; | 2017-03-01 |
| 230 | Phase I/II Randomized, Open-label Trial to Evaluate The PK, Safety, and Outcomes of Treatment Including High Dose Rifampicin +/- Levofloxacin Vs Standard Treatment for Pediatric Tuberculous Meningitis (TBM) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this open-labeled, randomized clinical trial, the Investigator will assess the safety and pharmacokinetics (PK) of model-optimized doses of rifampicin (RIF) with or without levofloxacin (LEVO) given to children as part of multidrug treatment for tuberculous meningitis (TBM) versus standard treatment. The Investigators will also assess functional and neurocognitive outcomes by treatment group, as measured by the Pediatric Modified Rankin Score (MRS) and the Mullen Scales of Early Learning (MSEL), respectively. |
KELLY DOOLEY; | 2017-02-22 |
| 231 | The Neuro Zti Cochlear Implant System Efficacy and Safety in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess the efficacy and the safety profile of the Neuro Cochlear Implant System (CIS) in adults with severe-to-profound hearing loss. |
DAVID SCHRAMM; | 2017-02-02 |
| 232 | Impact of HIV-infection on Clinical Characteristics and Outcomes on Stroke in Uganda PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will recruit participants from three tertiary care hospitals in Uganda into an observational cohort study of people living with HIV/AIDS (PLWHA) and HIV-uninfected persons matched for gender and residency, presenting with CT-confirmed stroke. We will collect socio demographic, clinical, laboratory, radiologic, cardiac, and clinical neurologic disease measures to investigate the effect of HIV-infection on 1) clinical and radiologic presentation, 2) risk factor profiles; and 3) stroke outcomes (death or disability). |
AMIR ABDALLAH; | 2017-02-01 |
| 233 | A Phase 2b Open-Label Multi-Center Study Assessing The Immunological Persistence of Antibodies at Approximately 2 Years After The Last Meningococcal Vaccination in Study V102_15 (NCT02212457) and The Response to A Booster Dose of GSK MenABCWY or Meningococcal Serogroup B Vaccines, in Healthy Adolescents PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the persistence of 2 or 3 doses of the GSK MenABCWY vaccine, or 2 doses of GSK rMenB+OMV vaccine (Bexsero) administered to healthy adolescents at approximately 24 months after the last meningococcal vaccination in the parent study V102_15(NCT02212457), compared with baseline antibody levels in vaccine naïve subjects at similar age at enrolment. |
GLAXOSMITHKLINE | 2016-11-15 |
| 234 | Sertraline in Addition to Standard of Care Treatment for Coccidioidomycosis Related Papers Related Patents Related Grants Related Experts View Highlight: In this study patients will be randomized 1:2 to receive either standard of care treatment or standard of care + Sertraline 200mg/day for 2 weeks, then 400 mg/day for 50 weeks for treatment of disseminated and meningeal coccidioidomycosis. |
SIMON PAUL; | 2016-11-01 |
| 235 | Comparison of Ringer Lactate and Isotonic Acetate Solution As Maintenance Fluids in Children Undergoing Elective Laparoscopic Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In children fluids are supplemented during surgery to provide volume, to maintain blood glucose levels, electrolyte balance and to meet the ongoing fluid losses during surgery. Fluid replacement during surgery since decades has been based on the Holliday and Segar method.These authors proposed that water maintenance in children includes: 100 millilitre (ml)/100 kilocalorie (kcal) for the first 10 kg of body weight, 50mL/100 kcal for 11-20 kg and 20mL/100 kcal for every kilogram of body weight above 20 kg. The maintenance electrolyte requirements of 3 mEq/100 kcal for sodium and 2 mEq/100 kcal for potassium per day, … |
KARTHIK RAM A; | 2016-09-01 |
| 236 | Impact of The Serratus Plane Block in Pain and The Use of Opioids in Breast PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this project is to evaluate the analgesic efficacy of a regional anesthesia technique ( interfascial block at the serratus muscle) performed in patient undergoing breast surgery and the effect of this technique on postoperative analgesia. |
GUIDO MAZZINARI; | 2016-08-02 |
| 237 | Immunogenicity and Safety of Adjuvant and Adjuvant-Free Meningococcal Groups A and C and Haemophilus B Conjugate Vaccine in Infants 2 to 5 Months of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate Immunogenicity and Safety of Adjuvant and Adjuvant-Free Meningococcal Groups A and C and Haemophilus b Conjugate Vaccine in Infants 2 to 5 Months of Age. Primary objective: – To demonstrate the non-inferiority of the antibody responses to meningococcal serogroups A, C and Haemophilus influenzae type b following the administration of adjuvant-free MenAC-Hib conjugate vaccine compared to those observed following the administration of adjuvant MenAC-Hib conjugate vaccine. – To describe the safety profile of adjuvant-free MenAC-Hib conjugate vaccine compared to that of adjuvant MenAC-Hib conjugate vaccine. Secondary objective: •To compare the antibody level of meningococcal serogroups A, … |
BEIJING ZHIFEI LVZHU BIOPHARMACEUTICAL | 2016-08-01 |
| 238 | Powder Topical Rifampicin on Reducing Infections After Neural Tube Defect Surgery in Infants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The correct timing and technique of neural tube defect (NTD) repairs significantly decreases the morbidity and mortality of NTD cases. However, infections related to the surgery are still common. We investigated the effects of topical rifampicin (RIF) combined with routine prophylaxis in newborns with open NTD. |
NIHAT DEMIR; | 2016-08-01 |
| 239 | A Phase 1, Double Blind, Randomized, Controlled Study to Evaluate The Safety and Immunogenicity of A New Meningococcal Conjugate Vaccine Containing Serogroups A,C,Y,W and X in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the safety of adjuvanted and non-adjuvanted formulations of MCV-5 vaccine. The secondary objective is to assess the immune response of adjuvanted and non-adjuvanted formulations of MCV-5 vaccine. |
WILBUR CHEN; | 2016-08-01 |
| 240 | Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Two innovative approaches, pulsatile orocutaneous entrainment of non-nutritive suck via orosensory entrainment (NTrainer) device technology and serial salivary gene expression analyses, will be merged to examine the relation between gene expression, oral somatosensory stimulation, feeding behavior, and neurodevelopmental outcomes at 18 months corrected age (CA) on 180 extremely preterm infants [EPIs] (24 0/7-26 6/7 GA and 27 0/7 – 28 6/7 GA) enrolled at three neonatal intensive care units: Catholic Health Initiative (CHI) Health St. Elizabeth (Lincoln, NE), Tufts Medical Center (Boston, MA), and Santa Clara Valley Medical Center (San Jose, … |
STEVEN M BARLOW; | 2016-07-13 |
| 241 | Intravenous Immunoglobulin Therapy for Small Fiber Neuropathy: A Randomized, Double-blind, Placebo-controlled Study on Efficacy and Safety PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Small fiber neuropathy (SFN) is the most common cause of neuropathic pain in peripheral neuropathies, with a prevalence of at least 53/100.000. Patients with SFN may have excruciating pain and current anti-neuropathic and other pain drugs do not relief pain substantially. Several studies suggested an immunological basis in SFN and case studies have reported efficacy of treatment with intravenous immunoglobulin (IVIg) in patients with SFN. It is therefore conceivable that immunological mechanisms play a role in idiopathic SFN (I-SFN). However, … |
CATHARINA G. FABER; | 2016-07-01 |
| 242 | Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multimodality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is the proof of concept study with multi-modality approach (using intra-thecal bioactive peptides, stem cells, laser and transcranial IV laser and Median Nerve stimulation as adjuvants) in cases of brain death due to traumatic brain injury having diffuse axonal injury to document possibility of reversal of brain death (BD). |
HIMANSHU BANSAL; | 2016-07-01 |
| 243 | A Single-center, Open, Phase I Clinical Trial to Evaluate Safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Healthy Volunteers Aged Above 3 Months PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate safety of meningococcal ACYW135 polysaccharide conjugate vaccine in healthy volunteers aged above 3 Months |
BEIJING ZHIFEI LVZHU BIOPHARMACEUTICAL | 2016-06-01 |
| 244 | Immunogenicity and Safety of Bivalent Meningococcal Serogroups A and C Tetanus Toxoid Conjugate Vaccine in Chinese Healthy Children Aged 3 Months to 5 Years.: A Randomized, Blinded, Positive Controlled Phase III Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Invasive meningococcal disease and meningococcal meningitis caused by Neisseria meningitidis have their highest incidence in children, with a second peak in adolescents and young adults. The most important disease-causing serogroups are meningococcal serogroups A (MenA) and MenC in Asia, such as China. The specific vaccine use in each country depends on the predominant serogroups, cost, … |
JIANGSU PROVINCE CENTERS FOR DISEASE CONTROL AND PREVENTION | 2016-05-12 |
| 245 | Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis And/or Septic Shock PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether an aggressive strategy of severe sepsis patients since pre hospital care, including early antibiotics administration, hemodynamic optimization, and opotherapy when indicated, could reduce mortality |
ROMAIN JOUFFROY; | 2016-05-09 |
| 246 | Incidence, Risk Factors and Impact on Renal Function of The Appearance of Crystalluria Under High-dose Intravenous Amoxicillin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Intravenous high-dose amoxicillin is a frequently prescribed antibiotic in intensive care units and infectious disease departments, in such indications as meningitis, endocarditis, listeriosis, or documented susceptible osteo-articular infections. Among possible side effects is the occurrence of amoxicillin crystalluria. Its incidence is unknown. It is deemed uncommon but literature is poor and its incidence is probably under-estimated. It can be complicated with hematuria or acute renal failure and may require renal replacement therapy. measures that can limit the impact of this nephrology crystalluria. Since the beginning of 2014, … |
CHU DE REIMS | 2016-05-01 |
| 247 | Diagnostics and Pharmacotherapy for Severe Forms of TB PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Major Research Aim: To study novel molecular diagnostics and the pharmacokinetic variability among a spectrum of TB disease states, including severe forms of TB like disseminated TB, TB meningitis and drug resistant TB, among adults and children from multiple international sites. |
SCOTT HEYSELL; | 2016-04-28 |
| 248 | Integrating The Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The DREAMM project is investigating whether the DREAMM interventions (1) Health system strengthening, 2) Co-designed education programs tailored to frontline healthcare workers, 3) Implementation of a diagnostic and treatment algorithm and, 4) Communities of practice in infectious diseases and laboratory capacity building) when combined reduce two week all-cause mortality of HIV-associated meningo-encephalitis in African LMICs. |
ANGELA LOYSE; | 2016-04-23 |
| 249 | Optimizing Sysmex Technology As An Innovative Tool to Differentiate Between Malaria (PALUdism) and BACterial Infections in A Malaria Endemic Region PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe malaria and bacterial Blood Stream Infections (bBSI) are impossible to differentiate clinically. This poses a particular threat in low resource areas, where bBSI is often not diagnosed due to the unavailability of rapid diagnostic means. Even if used appropriately, the sensitivity of blood culture to diagnose bBSI is estimated to be around 50%. To counter the high mortality rate associated with bBSI, … |
ANDRE VAN DER VEN; | 2016-04-01 |
| 250 | Assessment of The Performance of LYoplant® ONlay for Duraplasty. A Non-interventional, Multi-centre Post Market Clinical Follow-up (PMCF) Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this Post Market Clinical Follow-up Study is to collect clinical data on the performance of Lyoplant® Onlay. To assess the performance of the product, various safety and efficacy parameters have been selected. |
AESCULAP AG | 2016-04-01 |
| 251 | Mortality and Morbidity in A Large Cohort of Asplenic Patients: A Nationwide Survey From The Italian Network on Asplenia PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Spleen is involved in several functions, such as the production of protective antibodies, the removal of unwanted particulate matter from the blood (eg bacteria) and also the storing of blood cells, especially white cells and platelets. Asplenia is a status due to spleen absence or dysfunction, which results from several rare diseases. Congenital Asplenia is a condition with absent or dysfunctional spleen, associated with other congenital abnormalities; functional asplenia is a status with present but dysfunctional spleen, related to many rare diseases, such as sickle cell disease, thalassemia, essential thrombocythaemia, … |
SOCIETÀ ITALIANA TALASSEMIE ED EMOGLOBINOPATIE | 2016-03-01 |
| 252 | Host-pathogen Interactions in Meningococcal Disease: Finding The Key That Fits The Lock Related Papers Related Patents Related Grants Related Experts View Highlight: At any time, around 10% of people carry meningococcal bacteria in the nose and throat, which can cause meningitis, blood poisoning and other serious illnesses. Most people carry these bacteria and never become ill, yet a very small proportion go on to develop these illnesses which can result in life long disabilities or death. The mechanism by which this happens is poorly understood and has been studied in various ways, usually focussing on the bacteria or on the individual, … |
SHAMEZ LADHANI; | 2016-03-01 |
| 253 | Randomized, Double-blind, Multicenter, Phase III Study Comparing The Efficacy and Safety of Retosiban Versus Placebo for Women in Spontaneous Preterm Labor PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study’s primary objective is to demonstrate the superiority of retosiban to prolong pregnancy and improve neonatal outcomes compared with placebo. It is a Phase III, randomized, double-blind, parallel-group, multicenter study and will be conducted in approximately 900 females, aged 12 to 45 years, with an uncomplicated, singleton pregnancy and intact membranes in preterm labor between 24^0/7 and 33^6/7 weeks of gestation. Eligible maternal subjects will be randomly assigned in a 1:1 ratio to receive either retosiban IV infusion or placebo IV infusion over 48 hours. If not previously administered, … |
GLAXOSMITHKLINE | 2016-02-29 |
| 254 | Neurovirus Emerging in The Americas Study (NEAS): Neurologic Manifestations of The Arbovirus Dengue, Chikungunya and Zika Infections in Colombia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center case-control study that aims to define the association between the exposure to an arbovirus infection and the development of a neurological syndrome in patients from Colombia. The study makes part of the Neurovirus Emerging in the Americas Study (NEAS) that is a collaborative effort that looks to combine the efforts of researchers, healthcare providers and patients in Colombia to establish a comprehensive registry of the clinical, radiological and laboratory profile of patients with new onset of neurological diseases associated mosquito-borne viruses, known as arboviruses. |
CARLOS A PARDO-VILLAMIZAR; | 2016-01-01 |
| 255 | Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Without Acquired Immune Deficiency Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to observe the clinical effect of intrathecal administration of liposomal amphotericin B in Cryptococcal Meningitis without Acquired Immune Deficiency Syndrome (AIDS). |
HUI BU; | 2016-01-01 |
| 256 | Rapid Test for Detection of The Focus of Infection in Post Neurosurgical Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Due to anatomical restrictions, the inflammatory response to intra-cerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage. However, diagnosing meningitis in patients after neurosurgery is complicated, due to brain tissue damage and changes in cerebrospinal fluid (CSF) caused by surgery. Hepatocyte growth factor (HGF) is a local, acute-phase protein. Previous studies on community-acquired septic meningitis reported high levels of intrathecal-produced HGF. Aim: The aim of present study is to evaluate a new platform for qualitative determination of HGF in body fluids and revealing the site of injury. Method: Based on a reverse-methachromacy method, … |
FARIBA NAYERI; | 2015-12-02 |
| 257 | The Role of Maternal TB Infection for Adverse Pregnancy and Infant Health Outcomes in Ethiopia – A Long-term Prospective Cohort Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Women living in low-income countries are at elevated risk of death in connection to pregnancy, as well as infants born to women in such settings. It is probable that several factors are involved, such as poverty, lack of education and access to healthcare. Infectious diseases constitute important threats to maternal health in resource-limited settings. Tuberculosis (TB) is reported to be the third leading cause of maternal death globally. Furthermore, TB can be transmitted from mother to child during pregnancy, with high risk of severe consequences for the infant. Despite these data, … |
PER BJORKMAN; | 2015-12-01 |
| 258 | Effectiveness of Maintaining A Prone Position After Use of An Epidural Blood Patch for The Treatment of Post-dural Puncture Headache Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to assess the rate of recurrence of headache following a first blood patch where patients will be positioned in the prone position for an hour after each blood patch needed during this study. |
CENTRE HOSPITALIER UNIVERSITAIRE DE NĪMES | 2015-12-01 |
| 259 | The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients. |
HUI BU; | 2015-11-01 |
| 260 | A Prospective Study to Estimate The Incidence of Diseases Specified As Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Infants and Young Children in Sub-Saharan Africa Prior to Implementation of The RTS,S/AS01E Candidate Vaccine PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pre-licensure cohort study is to estimate the incidence of adverse events of special interest (AESI), other adverse events (AE) leading to hospitalisation or death, meningitis and malaria in sub-Saharan African children under 5 years of age. The outcomes of this study will provide the baseline data for the post-licensure EPI-MALARIA-003 (115056) study that will evaluate the safety, effectiveness and impact of the RTS,S/AS01E vaccine. An interim analysis was performed on a sub-group of study participants enrolled in active surveillance from sites where the vaccine is currently implemented, … |
GLAXOSMITHKLINE | 2015-10-05 |
| 261 | Risk Factors & Outcomes for Clinically Documented Infections in Pediatric Cancer Patients With Fever & Neutropenia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to identify clinical and laboratory parameters, present at the time of initial evaluation that could help predict which children with cancer, fever, and neutropenia will be at risk for developing clinically documented infections and/ or complications. |
AHMED MOHAMMED MORSY; | 2015-10-01 |
| 262 | Valganciclovir for Suppression of HHV-8 Four Weeks Prior to Initiation of CART in Patients With Disseminated Kaposi Sarcoma Compare With Standard Therapy, Its Impact on The Development of IRIS and Attributable Mortality PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Kaposi sarcoma (KS) has an unpredictable course, patients with disseminated KS starting combined Antiretroviral Therapy can develop Immune Reconstitution Syndrome (IRIS), with a severe clinical presentation and high mortality (severe-IRIS-KS). The objective of this study is to evaluate the presence of Severe IRIS-KS and it´s attributable mortality in patients with AIDS and disseminated KS with the use of valganciclovir prior to the initiation of cART compared with the standard management of immediate cART initiation. |
VOLKOW FERNANDEZ PATRICIA AMALIA; | 2015-10-01 |
| 263 | Group B Streptococcal Carrier State Prevalence Among Arab Pregnant Women in Northern Israel District PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The incidence of early neonatal GBS (group B Streptococcus) infection in the Nazareth Hospital through the years 2006-2013 has been higher compared to the national average. On reviewing all the cases of infants with early GBS infection, revealed that some of these infants were born to mothers who are not included in any of the high-risk groups that need to have prophylactic antibiotic treatment before delivery. Therefore, the question was whether pregnant Arab women in the North district of Israel have a higher GBS carrier state rate than the general rate in Israel? |
MARWAN HAKIM; | 2015-09-01 |
| 264 | Multimodal Sonographic Monitoring of Cerebral Perfusion, Ventricle Seize and Optic Nerve Diameter During Weaning of Cerebrospinal Fluid Drainage Catheters: A Single Centre Observational Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As elaborated above only one study reported ultrasonographic changes of the width of the lateral ventricle during clamping of EVD/LD and indicated that ultrasound monitoring might be suitable. No firm data exists about the change of the width of the third ventricle, the diameter of the optic nerve or brain perfusion during clamping of the EVD/LD, … |
WERNER Z’GRAGGEN; | 2015-09-01 |
| 265 | SCD163 As A Potential Biomarker in Guillain- Barré Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Guillain- Barré syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy (AIDP) that often is triggered by an infection. GBS is characterized by progressing weakness and numbness and loss of tendon of reflexes. It can also include tingling sensation in the legs and arms. These symptoms occur due to an autoimmune attack on the myelin resulting in demyelination. The diagnosis is given by electrophysiological examination and clinical presentation. GBS is treated with intravenous immunoglobulin (IVIG) and plasma exchange (PE). Both treatments are equally effective. Most patients recover completely, … |
HENNING ANDERSEN; | 2015-09-01 |
| 266 | SCD163 & CD19 As Candidate Biomarkers in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) – A Study of SCD163 in The Cerebrospinal Fluid PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are characterized by progressive deterioration in muscle strength, loss of sensibility, diminished or absent reflexes and impaired fine motor control. Often it is caused by demyelination which is suitable for treatment but damage to the axons may also occur especially in case of insufficient treatment. CIDP and MMN are immune mediated neuropathies in which first choice of treatment is intravenous immunoglobulin (IVIG), … |
HENNING ANDERSEN; | 2015-09-01 |
| 267 | A Randomised Controlled Trial Comparing Two-Dose Priming With The 10-Valent Pneumococcal Conjugate Vaccine at 6 and 10 Weeks to 6 and 14 Weeks in Nepali Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A single centre open-label, parallel group, randomised controlled trial, recruiting healthy Nepalese infants aged 40-60 days, who present to the immunisation clinic at Patan Hospital, Kathmandu, Nepal, randomised to receive a 10-valent pneumococcal conjugate vaccine (PCV10) at either; … |
UNIVERSITY OF OXFORD | 2015-08-21 |
| 268 | Khushi Baby (KB): Efficacy and Impact Assessment of Novel Mobile Health Solution for Vaccination Record Keeping in Rural Udaipur, Rajasthan, India PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a three arm cluster randomized controlled trial where the unit of randomization is the immunization camp. Immunization camps are the sole provider of vaccinations in our study area and have catchment areas of several villages. The 96 immunization camps will be randomized evenly to one of three arms: 1. control arm; where near field communication (NFC) stickers will be placed on existing immunization booklets. These stickers can be scanned using a mobile phone with an installed application whereby information can be entered onto the phone and then scanned onto the sticker 2. pendant only; … |
MOHAMMAD SHAHNAWAZ; | 2015-08-01 |
| 269 | The Use of Near Infrared Spectroscopy and Magnetic Resonance Imaging Technique in The Evaluation of The Permeability of Blood-brain Barrier in Adults With Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to confirm the applicability and usefulness of the novel method of assessment of the permeability of the blood-brain barrier and in monitoring of the treatment of patients with meningitis. The proposed technique is based on evaluation of the kinetics of the indocyanine green (ICG) outflow from the brain with the use of near-infrared spectroscopy (NIRS). Usefulness of the NIRS-based method will be analyzed in relation to the reference method, which is contrast-enhanced magnetic resonance imaging (MRI). |
NALECZ INSTITUTE OF BIOCYBERNETICS AND BIOMEDICAL ENGINEERING POLISH ACADEMY OF SCIENCES | 2015-08-01 |
| 270 | Implementation and Evaluation of A Screening Strategy to Reduce Morbidity and Mortality Due to Cryptoccocal Meningo-encephalitis in ART Naive AIDS Patients With <100 CD4 Count at The Day Hospital of The Yaounde Central Hospital, Cameroon PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate systematic pre-antiretroviral cryptococcal antigen screening and pre-emptive fluconazole therapy in antigen positive patients, as a strategy to reduce morbidity and mortality due to AIDS associated cryptococcal meningitis in patients starting antiretroviral therapy at <100 CD4 in Cameroon. |
OLIVIER LORTHOLARY; | 2015-07-01 |
| 271 | A Study to Assess The Carriage of Pneumococci in Children Aged 1-5 Years, and Their Household Contacts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococci are bacteria which can cause serious and potentially life threatening illnesses like meningitis and blood poisoning. Pneumococcal vaccines (PCV) have been given in the national immunisation schedule since 2006.Carriage studies allow assessment of how the strains in the nose change over time, in that by clearing some strains away which other strains take up those niches in their place both in children and in their close/household contacts. This helps to inform the best use of the vaccines available and for future vaccine development and which strains would be useful to include. |
ELIZABETH MILLER; | 2015-07-01 |
| 272 | Survey on The Treatment Reality of Patients With EGFR Mutation-positive Non-small Cell Lung Cancer PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: According to the recent report using EGFR tyrosine kinase inhibitors (EGFR-TKI), there is all over survival of the EGFR gene mutation-positive NSCLC in a tendency to extension. However, the real situation and the reason are not clarified.This observational study collects the data of EGFR gene mutation-positive NSCLC approximately 2,000 from the medical record of approximately 20 facilities in Japan and observes the treatment reality of EGFR gene mutation-positive NSCLC. |
ASTRAZENECA | 2015-06-19 |
| 273 | Determination of Plasmatic and CSF Levels of High Doses of Micafungin in Neonates Suffering From Systemic Candidiasis And/or Candida Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to evaluate the pharmacokinetic profile of micafungin administered to neonates suffering from systemic candidiasis. This study will also evaluate the proportion of success and of failure of the therapy with micafungin among treated neonates and will identify a conversion factor to relate plasma levels of micafungin into capillary and venous blood measured through blood samples from the heel and from a peripheral vein, collected simultaneously. Safety of micafungin in neonates will also be assessed. |
ASTELLAS PHARMA GLOBAL DEVELOPMENT | 2015-05-30 |
| 274 | Spinal Infection Management With Structural Allograft PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background. Bone infections can involve the vertebral column, intervertebral disc space, spinal canal and soft tissues, can generate neurological deficit in addition to the destruction of the bone that causes functional disability. Vertebral osteomyelitis is the most frequent, affecting 2 to 7 patients per 100,000 habitants. Management is bone debridement and bone reconstruction. Objective. Demonstrate that the use of bone allograft is a functional method to stabilize the spine after a bone spinal infection Material and methods. Patients with vertebral bone destruction are included in two groups. Bone allograft group will receive bone structural allograft; … |
CARLOS A ACOSTA-OLIVO; | 2015-05-14 |
| 275 | Reduction of Infection in Neonatal Intensive Care Units Using The Evidence-based Practice for Improving Quality: A Cluster Randomised Trial PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This 4-year cluster randomized controlled trial aims to determine whether implementation of Evidence-based Practice for Improving Quality (EPIQ) method can reduce hospital-acquired infection in Chinese Neonatal Intensive Care Units (NICUs). |
YUN CAO; | 2015-05-01 |
| 276 | Infection, Sepsis and Meningitis in Surinamese Neonates PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Suriname is a small developing country in South America with a population of half a million people. Early neonatal death in Suriname is high with 16 per 1000 live births. Unpublished data from the Suriname Perinatal and Infant Mortality Survey estimate contribution of infection to early neonatal mortality at 25% (4 per 1000 live births) of all deaths. In comparison, … |
RENS ZONNEVELD; | 2015-05-01 |
| 277 | Association of Serum 25-hydroxyvitamin D Levels and Outcomes in Children With Bacterial Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis. |
GANG LIU; | 2015-05-01 |
| 278 | Rheolytic Thrombectomy For Adult Intraventricular Haemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intraventricular haemorrhage (IVH) – bleeding into the normal fluid spaces (ventricles) within the brain – is associated with a high risk of death or significant long-term disability. IVH leads to an increase pressure within the head and triggers inflammation and swelling in the surrounding brain. The ideal treatment for IVH would both rapidly relieve pressure and safely remove as much blood as possible to prevent any further injury to the brain. Currently, patients are managed by inserting a tube into the ventricle that drains fluid to the outside and helps reduce pressure, but does not address the blood clot itself, … |
KAROL PALWEL BUDOHOSKI; | 2015-05-01 |
| 279 | Outcome of The Endoscopic Repair of Frontal Sinus Cerebrospinal Fluid Leak PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This retrospective study was conducted on patients with frontal sinus leaks came to ENT departments of Al-Azhar University Hospital, New Damietta, Egypt, for a period of five years. |
ABDULKARIM HASAN; | 2015-05-01 |
| 280 | Effectiveness of Anisodamine for The Treatment of Critically Ill Patients With Septic Shock: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Anisodamine has been widely used in China for its pharmacological effect on improving microcirculation during shock. It has been reported that anisodamine is effective in reducing mortality rate in children with meningitis. however, its effectiveness in patients with septic shock has not been systematically investigated. The aim of the study is to investigate the effectiveness of anisodamine in the treatment of patients with septic shock. |
ZHONGHENG ZHANG; | 2015-04-01 |
| 281 | Investigating Meningococcal Vaccines in Adults – An Exploratory, Open-label, Immunogenicity Study of A Licensed Meningococcal Capsular Group B Vaccine (4CMenB, Bexsero®) in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be an open label, exploratory immunogenicity study conducted by the Oxford Vaccine Group, University of Oxford. This study will investigate the breadth of protective activity of serum anti-FHbp antibody responses of adults immunized with 4CMenB (Bexsero®) vaccine as well as investigating the nature of the B-cell and T-cell responses induced by vaccination. The investigators aim to enroll 15 to 20 healthy adults aged 18 to 60, who will be immunized with two doses of 4CMenB (Bexsero®) two months apart according to the licensed schedule. Blood samples will be obtained at baseline and after each dose of vaccine. |
UNIVERSITY OF OXFORD | 2015-04-01 |
| 282 | Open and Exploratory Trial to Investigate The Pharmacokinetic of Ceftaroline in Patients With CSF Device PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ceftaroline is a piece of new cephalosporin very active on resistant staphylococci in methicillin (SEMR: Staphylococcus Epidermidis Resistant in Methicillin, SMAR: Staphylococcus Aureus Resistant in Methicillin)and/or in vancomycin ; Ceftaroline is also very active on pneumococci resistant in penicillin and/or 3rd generation of cephalosporins. Ceftaroline was approved by the European Medicines Agency for the treatment of complicated skin and soft tissue infections and community-acquired pneumonia. Scientific literature describes a good efficiency in septicemy and/or SAMR endocarditis. Besides, … |
CENTRE HOSPITALIER UNIVERSITAIRE DIJON | 2015-04-01 |
| 283 | Adjunctive Sertraline for The Treatment of HIV-Associated Cryptococcal Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase III trial to determine whether adjunctive sertraline will lead to improved survival 18-week survival. There was an initial phase I/II unmasked dose finding pharmacokinetic study of CSF concentrations in 172 persons conducted from August 2013 to August 2014. See NCT03002012. |
DAVID B MEYA; | 2015-03-09 |
| 284 | Systematic Search for Primary Immunodeficiency in Adults With Unexplained Recurrent And/or Severe Infections With Encapsulated Bacteria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections – especially upper and lower respiratory tract infections and meningitis. The literature data suggest that PIDs are under-diagnosed in adults. The current European and US guidelines advocate screening adults for PIDs if they present recurrent benign especially upper and lower respiratory tract infections, … |
GUILLAUME LEFEVRE; | 2015-03-01 |
| 285 | Continuous Adductor Canal Block (CACB) Vs. Combined Spinal Epidural (CSE) in Total Knee Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose: Compare continuous adductor canal block (CACB) to Combined Spinal Epidural (CSE) for total knee arthroplasty in terms of mobility, post-operative pain, and analgesic use. Hypothesis: CACB will provide better mobility than CSE post operatively. |
CRAIG J DELLA VALLE; | 2015-01-01 |
| 286 | Xpert MTB/RIF Assay for Diagnosis of Tuberculous Meningitis (TBM) in Maharaj Nakorn Chiang Mai Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Early diagnosis and appropriate treatment of tuberculous meningitis (TBM) are crucial steps to reduce morbidity and mortality. The WHO recommended to use Xpert MTB/RIF assay to diagnose pulmonary TB, pediatrics TB, extra pulmonary TB and rifampicin resistance. However, the data of accuracy in diagnosis of TBM is still lacking. This study aimed to find out the diagnostic performance of Xpert MTB/RIF assay for the diagnosis of tuberculous meningitis, especially in patients who presented with subacute lymphocytic meningitis. |
PORAMED WINICHAKOON; | 2015-01-01 |
| 287 | PCR Technique of A Commercial Test and Blood Culture to Early Detect Sepsis in NICU PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Although advances in neonatal care have improved survival and reduced complications in preterm infants, sepsis still contributes significantly to mortality and in Neonatal Intensive Care Units (NICUs), in particular for very-low-birth-weight (VLBW, <1500 g) and extremely-low-birth-weight (ELBW, <1000g). Based on the timing of the infection neonatal sepsis has been classified into early-onset sepsis (EOS) and late-onset sepsis (LOS), ... |
LIDIA DECEMBRINO; | 2015-01-01 |
| 288 | Immunogenicity of A U.S.-Licensed Meningococcal Serogroup B Vaccine (Trumenba) in Adults at Increased Risk of Meningococcal Disease Because of Occupational Exposure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the breadth of protection against meningococcal disease in humans immunized with a newly FDA approved meningococcal B vaccine, trade name Trumenba® manufactured by Pfizer Vaccines. As a secondary goal the investigators will investigate underlying mechanisms by which human anti-FHbp antibodies elicit complement-mediated bactericidal activity. |
DAN GRANOFF; | 2015-01-01 |
| 289 | Open Randomized Trial Evaluating Four Anti-pneumococcal Vaccine Strategies With Fractionated Doses of Non Conjugate Polysaccharide Vaccine to Prevent Hyporesponse in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Immune response analysis after the combination of PCV13 and PPV23 will lead to evaluate if a prime with PCV13 help to obtain a good response to repeated dose of PPV23.The hyporesponsiveness following the unconjugated vaccine is associated with high polysaccharide antigen concentration. Several issues limit the development and recommendation of anti-pneumococcal vaccine in adult’s patients at risk. Reduced doses of unconjugated polysaccharide antigens would bypass the hyporesponsiveness and maintain the expanded coverage serotype. A better knowledge of immune response following the combination of two vaccines in adults is essential. In addition, … |
HÉLÈNE BODILIS; | 2014-12-04 |
| 290 | A Randomized Double Blinded Phase 2b Clinical Trial Comparing Standard Dose With Two Higher Doses of Rifampicin for Treatment of Adults With Tuberculous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculous meningitis (TBM) is the most severe form of tuberculosis infection with high mortality. Current treatment regimens are not based on clinical trials. Rifampicin is a key drug for TBM, but its penetration into the brain is limited, suggesting that a higher dose may be more effective. There are several highly relevant, outstanding questions related to the appropriate dose of rifampicin for TBM, before a multicenter phase 3 trial can be performed. These are: 1. Previous phase 2a randomized clinical trial (done in the same setting as this proposed study) suggests that high doses of intravenous rifampicin (600mg, … |
ROVINA RUSLAMI; | 2014-12-01 |
| 291 | Inflammation in Amyotrophic Lateral Sclerosis – A Study of Soluble Cluster of Differentiation 163 in The Cerebrospinal Fluid PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Amyotrophic lateral sclerosis (ALS) is a fatal disease with progressive muscle weakness leading to severe disability and eventually death.Since the diagnosis relies on clinical features and electromyographic abnormalities, which may occur rather late in the disease course, there is a need to identify diagnostic tests that can confirm or exclude the diagnosis of ALS in the earlier phase of the disease. More recently, there are studies suggesting neuroinflammation to play a role for the development of ALS. Cluster of differentiation 163 is found to be up regulated in a large range of inflammatory diseases. At the investigators lab, … |
UNIVERSITY OF AARHUS | 2014-12-01 |
| 292 | Diagnostic Performance of Clinical Signs Patients Suspected of Meningitis to Emergencies. Prospective and Multicentric Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Meningitis are serious infections. Evidenced by high rates of mortality and sequelae. However, these diseases have a relatively small impact. Also physician services Home Emergencies they must be vigilant, alert, for clinical signs to be suspected meningitis. Indeed, it is only after this essential clinical milestone that will be carried out a lumbar puncture which will confirm the diagnosis and to quickly begin treatment. Unfortunately, if recent studies can improve the therapeutic management of patients with meningitis, … |
CÉDRIC BRETONNIERE; | 2014-11-01 |
| 293 | Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine, in children hospitalized with pneumonia, if an extended duration of oral antibiotics (10 days) will be superior to a shorter duration (3 days) of antibiotics in improving clinical outcomes. Secondary Aims: 1. Describe the prevalence of respiratory viruses and bacteria at presentation. 2. Investigate the depression, anxiety and stress scores (DASS21) and quality of life scored (QOL) by parents of the children during admission, pre-discharge and post discharge and at follow-ups. |
ANNA MARIE NATHAN; | 2014-11-01 |
| 294 | A Pilot Phase II Randomized Controlled Double Blind Trial of 81mg Aspirin Daily Vs. 1000 Mg Aspirin Daily Vs. Placebo As Adjunctive Therapy in HIV Negative Adults With Tuberculous Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculous meningitis is a severe brain infection which often causes disability and death even when treated with the best available treatment. Aspirin is a type of anti-inflammation drug which can reduce the inflammatory response in brains of patients with tuberculous meningitis, … |
GUY THWAITES; | 2014-10-17 |
| 295 | Paediatric Post Pneumococcal Conjugate Vaccine Nasopharyngeal Carriage Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators intend to investigate the carriage of pneumococci and other respiratory microbes since the introduction of pneumococcal conjugate vaccines (Prevenar 7 and Prevenar 13). The principal aim is to gain a collection of samples that can be used to help investigate any changes that might occur in the epidemiology of microbes that are carried in the upper respiratory tract and which may cause respiratory disease, … |
SAUL FAUST; | 2014-10-01 |
| 296 | An Evaluation of The Immune Response to Pentavalent Rotavirus Vaccine After A Supplemental Dose Given at 9 Months of Age With Local EPI Vaccines in Mali PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an evaluation of the immune response to pentavalent rotavirus vaccine (PRV) after an additional fourth dose is given at 9 months of age with local World Health Organization (WHO) Expanded Programme on Immunization (EPI) vaccines in Mali. |
SAMBA O SOW; | 2014-10-01 |
| 297 | A Study of Subcutaneous Immunoglobulin As Chronic Treatment for Patients With Chronic Inflammatory Demyelinating Polyneuropathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are using self administered subcutaneous IG in patients with CIDP who require IVIG. Safety, efficacy, and patient satisfaction will be examined. |
TUAN VU; | 2014-09-01 |
| 298 | A Phase 2b, Randomized, Controlled, Observer-Blind, Multi-Center Study Assessing The Immunogenicity and Safety of GSK Meningococcal ABCWY Vaccine Administered at Different Schedules Compared to GSK Meningococcal Group B Vaccine, in Healthy Adolescents PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purposes for conducting the study are firstly to assess immunological non-inferiority of the MenABCWY vaccine, administered according to 0, 2 month schedule to healthy adolescents 10 to 18 years of age, to those of the licensed rMenB+OMV vaccine (Bexsero™) in terms of hSBA GMTs at one month after the second vaccination, secondly to give the flexibility for the national vaccination program by showing the safety and immunogenicity of MenABCWY administrated according to four different vaccination schedules and additionally to evaluate a potential benefit of the 3-dose vaccination series. |
GLAXOSMITHKLINE | 2014-08-21 |
| 299 | Is Outpatient Management of PPROM Equivalent to Hospital Management PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to compare the maternal and neonatal outcomes in the patients with PPROM who are managed at home versus those managed at hospital, half the patients will be managed at home and the other half will be managed inpatient. |
DINA MOSTAFA IBRAHIM; | 2014-08-01 |
| 300 | The Outcomes of Autologous Bone Marrow-derived Mononuclear Cell Transplantation In-patient With Neurological Sequelae Due to Encephalitis or Meningitis at Vinmec International Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and efficacy of autologous bone marrow-derived mononuclear cell transplantation in-patient with neurological sequelae due to encephalitis or meningitis |
LIEM T NGUYEN; | 2014-06-16 |
| 301 | A Prospective Randomized Controlled Trial to Investigate The Effects of Training Emergency Medical Services (EMS) Personnel in Recognizing and Initiating Treatment in The Prehospital Setting Together With Early Administration of Antibiotics for Patients Suspected of (Severe) Sepsis and Septic Shock PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Sepsis is one of the most frequent reasons for referral to emergency departments (EDs) worldwide. The incidence of sepsis is likely to rise in the upcoming years. Sepsis has a tendency to become more serious when left untreated with a high mortality rate, exceeding even those of myocardial infarction and stroke. Therefore, much effort has been put in to start with appropriate therapy as early as possible. Early goal-directed therapy (EGDT) in the emergency department with fluid resuscitation, … |
PRABATH W.B. NANAYAKKARA; | 2014-06-01 |
| 302 | Prospective Study of The Etiology, Pathogenesis, Clinical Picture and Outcome of Aseptic Meningitis in Slovenia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is: – to establish etiology of acute aseptic meningitis/meningoencephalitis in Slovenia – to assess the clinical course and outcome of tick-borne encephalitis and Lyme neuroborreliosis – to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with tick-borne encephalitis and Lyme neuroborreliosis |
FRANC STRLE; | 2014-06-01 |
| 303 | The Effect of Bedside Ultrasound Assistance on The Proportion of Successful Infant Lumbar Punctures in A Pediatric Emergency Department: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The reported rate of unsuccessful spinal taps in children, especially young infants, is high. Our hypothesis is that ultrasound assistance can improve the success rate of spinal taps. |
AARON E CHEN; | 2014-05-01 |
| 304 | Observation Study on Early Waning of Maternal Measles and Meningitis C Antibodies PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Maternal antibodies (measles and meningitis C) may wane in the first six months after birth. – Geometric mean titers(GMTs) of measles and meningitis C. – Follow-up on 0 month, 3rd month,5th month and 7th month after birth. |
MING WANG; | 2014-05-01 |
| 305 | A New Predictor Marker for Cochlear Implants Infection: Neutrophil/ Lymphocyte Ratio PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Surgical site infections associated with the cochlear implant can have serious consequences. Although advances in surgical techniques reduce these complications, it may be necessary to remove a device that works as a last resort as a result of ongoing infection. The removal of these devices, which are very expensive, increases the cost and takes the chance of hearing patients with this device. Therefore, … |
OZKAN ONAL; | 2014-05-01 |
| 306 | Tissue and Fluid Collection Pilot Study to Develop Circulating Tumor DNA in Cerebrospinal Fluid As An Early Biomarker of LM in Patients With Metastatic Solid Tumor Cancer Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn whether the DNA from cancer tumor cells can be found in the cerebral spinal fluid (CSF) that bathes the brain and spinal cord of patients before malignant the cancer cells themselves are able to be found in the CSF. The researchers doing this study hope this information can be used to develop a way to diagnose LM earlier . |
LARA K. RONAN; | 2014-05-01 |
| 307 | Surveillance of Invasive Pneumococcal Infections in Adults (Excluding Meningitis) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Given the frequency and severity of invasive pneumococcal infections and questions about the place of VPC-13 in the prevention of pneumococcal infections in adults based on the presence of risk factors, current laboratory surveillance should be supplemented with data on the clinical features of adult invasive pneumococcal infections (IPI) cases. In particular it is necessary to collect for these cases, the clinical forms, the severity and the existence of risk factors and to make the link between these characteristics and those strains of pneumococci responsible for the IPI in particular, … |
MARIE PLOY; | 2014-04-01 |
| 308 | A PHASE IIIB, OPEN, MULTI-CENTER STUDY TO EVALUATE THE LONG-TERM ANTIBODY PERSISTENCE AT 6, 7, 8, 9 AND 10 YEARS AFTER THE ADMINISTRATION OF ONE DOSE OF MENINGOCOCCAL CONJUGATE VACCINE MENACWY-TT VERSUS ONE DOSE OF MENINGOCOCCAL POLYSACCHARIDE VACCINE MENCEVAX(REGISTERED) ACWY, AND TO EVALUATE THE SAFETY AND IMMUNOGENICITY OF A BOOSTER DOSE OF MENACWY-TT VACCINE ADMINISTERED 10 YEARS AFTER PRIMARY VACCINATION OF 11-55 YEAR OLD SUBJECTS WITH MENACWY-TT OR MENCEVAX (REGISTERED) ACWY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the long-term antibody persistence from 6, 7, 8, 9 to 10 years post-administration of MenACWY-TT conjugate vaccine as compared to Mencevax ACWY when given to healthy subjects 11 to 55 years of age. In addition, … |
PFIZER | 2014-04-01 |
| 309 | Immunoglobulin for Necrotizing Soft Tissue Infections: A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to estimate the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo (saline) on the patient-reported outcome measure Physical Component Summary Score (PCS) of the SF-36 in patients with necrotizing soft tissue infections (NSTI). |
ANDERS PERNER; | 2014-04-01 |
| 310 | Cross-sectional Study to Establish The Point Prevalence of Serotype 19A Pneumococcal Nasopharyngeal Carriage of Fully Vaccinated Children Aged 13-48 Months Following Introduction of PCV13 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococcus is a bacteria that causes disease of the respiratory tract (pneumonia and middle ear infections), blood poisoning, and meningitis. It is frequently carried by people in back of the throat without symptoms. Pneumococcal carriage in the Thames Valley region has been studied over the last 12 years with carriage rates having been shown to be reflective of disease potential and hence vaccine effect. During this time pneumococcal vaccines have been introduced into the routine immunisation schedules of this community. The PCV7 (A vaccine against 7 types of pneumococcus) vaccine has subsequently been noted to have had a significant impact in reducing vaccine serotype carriage and disease. Herd protection (indirect protection of unvaccinated individuals) has also been implicated with vaccine serotypes not being carried in parents of vaccinated children. The most common serotype carried since the introduction of PCV7 is 19A, which is included in the PCV13 vaccine (A vaccine against 13 types of pneumococcus). PCV13 has superseded PCV7 in the routine immunisation schedule, however its impact on carriage and disease in this community is yet to be evaluated. |
ANDREW J POLLARD; | 2014-03-01 |
| 311 | HPV Vaccination: An Investigation of Physician Reminders and Recommendation Scripts PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary, Secondary, and Exploratory Objective(s): Primary objective: To evaluate the effect of interventions on 1st dose uptake of HPV vaccine. |
GREGORY D ZIMET; | 2014-02-01 |
| 312 | Phase 1 Study of The Safety and Immunogenicity of A 2-Dose Regimen of West Nile/Dengue 4-3´Δ30 Chimeric Virus Vaccine (WN/DEN4Δ30), A Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: West Nile virus (WNV) is considered an emerging virus in the United States, and infection can lead to severe illness in older adults. This study will evaluate the safety of and immune response to a live West Nile virus vaccine (WN/DEN4Δ30) for the prevention of West Nile encephalitis in adults 50 to 65 years old. |
ANNA DURBIN; | 2014-02-01 |
| 313 | Etiology of Orphan Community-based Meningitis and Meningo-encephalitis PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to assess the contribution of a non-invasive sampling (pharyngeal swab) in the diagnosis of community based meningitis or meningo-encephalitis. |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2014-01-01 |
| 314 | Immunogenicity and Safety of Group A, C, Y and W135 Meningococcal Polysaccharide Vaccine in More Than 2 Years Old Children and Adults PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this double-blind study is to evaluate the safety, reactogenicity and immunogenicity of Group A,C,Y and W135 Meningococcal Polysaccharide Vaccine in 2 to 30 years-old Children and Adults. All subjects will receive 1 dose of Group A,C,Y and W135 Meningococcal Polysaccharide Vaccine. |
NIANMIN SHI; | 2013-11-01 |
| 315 | Clinical Outcomes of Cryptococcal Meningitis Among HIV-infected Patients in The Era of Antiretroviral Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cryptococcal meningitis is one of the most common central nervous system infections among HIV-infected patients. The outcome is generally severe. This study aims to determine long-term survival rate among HIV-infected CM patients in the era of antiretroviral therapy (ART). The secondary objectives are to clarify outcomes of CM and determine prognostic factors. |
PUNNEE PITISUTTITHUM; | 2013-11-01 |
| 316 | Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction in Patients Who Underwent Hip Surgery Under Regional Anesthesia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-operative cognitive dysfunction is defined as a decrease in cognitive functions which develop following surgery and anesthesia administration that can last up to weeks or even months after surgery. In this study, our main objective was to investigate the effect of preoperative hospitalisation period on early post operative cognitive dysfunction development and its risk factors in patients who underwent total hip replacement surgery for hip fractures under regional anesthesia. |
BURCU OZALP HORSANALI; | 2013-11-01 |
| 317 | Immunogenicity and Safety of Meningococcal (A, C, Y and W135) Conjugate Vaccine in Healthy Subjects 2 Months to 6 Years of Age in China PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this observer-blind study is to evaluate the safety, reactogenicity and immunogenicity of Meninggococcal (A,C,Y and W135) Conjugate Vaccine in 2 months to 6 years-old children. |
SHENGLI XIA; | 2013-10-01 |
| 318 | CSF Leak Following Microvascular Decompression: The Benefit of Routine Postoperative Lumbar Tap Related Papers Related Patents Related Grants Related Experts View Highlight: Even at centers with very large experience, the risk of cerebrospinal fluid (CSF) leakage in surgery for microvascular decompression is reported up to 3%. Prevention of leakage is important since meningitis may follow. Also, leakage usually means longer hospital stay and increased cost. In case of detected leakage extra sutures may be applied, placement of a lumbar drain may be considered or a revision and improved closure may be attempted. With leakage in the subcutaneous tissue, but not through the skin, … |
ST OLAVS HOSPITAL | 2013-10-01 |
| 319 | Study of The Immunogenicity of A Prime Boost Vaccination Strategy Combining Conjugated Anti-pneumococcal and Polysaccharide Anti-pneumococcal Vaccine Compared to Polysaccharide Anti -Pneumococcal Vaccine Alone in Patients With Sickle Cells Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Streptococcus pneumoniae is the major cause of bacterial infection in patients with sickle cells disease. The 23-valent pneumococcal polysaccharide vaccine (PSV) is supposed to be poorly immunogenic in these patients. We want to evaluate whether a prime with a 13-valent pneumococcal conjugate vaccine (PCV), able to induce immunologic memory, would improve the immune response against SP polysaccharides (SPP). Primary objective: To evaluate and compare the specific antibody response to a prime-boost vaccine strategy combining PCV prime at W0 followed by the administration of PSV boost at W4, … |
YVES LEVY; | 2013-09-16 |
| 320 | A Phase III/IV Randomised Open-label Study and Comparison of The Immunogenicity and Safety of A Single Adolescent Booster Dose of A Meningococcal Group C Conjugate-containing Booster Vaccine (Meningitec™, OR NeisVac-C™ , OR Menitorix™), When Given Concurrently With An Acellular Pertussis-containing Booster Vaccine (Repevax™ or IPV-Boostrix™) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The trial includes groups receiving various combinations of meningitis C and pertussis containing vaccines, to be administered concomitantly in adolescents due their school leaving booster vaccinations (as per UK routine immunisation schedule at 13-17 years of age). Immunogenicity and reactogenicity will be assessed. |
PUBLIC HEALTH ENGLAND | 2013-09-01 |
| 321 | An Open Label Randomized Controlled Phase IIb Trial to Determine The Safety of Oral Fluconazole in Combination With Flucytosine As Compared to Fluconazole Alone Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if treatment with two medicines in combination (fluconazole and flucytosine) is safe as compared with one medicine alone (fluconazole) for the treatment of an early infection with a fungus called cryptococcus. |
ANA-CLAIRE L MEYER; | 2013-09-01 |
| 322 | Preventing Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome in High-risk Patients: A Randomized Placebo-controlled Trial of Prednisone PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is the most common opportunistic infection amongst HIV-infected patients starting antiretroviral therapy (ART) in developing countries and thus the most frequent form of immune reconstitution inflammatory syndrome (IRIS). Paradoxical TB-IRIS occurs in 8- 43% of patients starting ART while on TB treatment and results in morbidity, hospitalisation, consumes health care resources and TB-IRIS may be fatal. We have previously demonstrated in a clinical trial that prednisone reduces morbidity when used for treatment of paradoxical TB-IRIS. This trial is a double-blind placebo-controlled trial of prophylactic prednisone (40mg/day for 2 weeks followed by 20mg/day for 2 weeks, … |
GRAEME MEINTJES; | 2013-08-30 |
| 323 | Quantitative Fluorescence Polymerase Chain Reaction (QF-PCR) in Group B Strep (GBS) Rectovaginal Colonization Diagnosis During Pregnancy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Estimate the sensitivity and specificity of Quantitative Fluorescence Polymerase Chain Reaction (QF-PCR) in diagnosing Group B Strep (GBS) rectovaginal colonization during pregnancy, and follow the outcome of the mothers and infants. According to the outcome of this study,the investigator wish to determine that wether QF-PCR is an appropriate screening method for GBS in primary hospitals in China. |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2013-08-01 |
| 324 | A Phase 2 Double Blind Study to Evaluate Safety and Immunogenicity of Meningococcal Meningitis Serogroups A, C, Y & W-135 Polysaccharide Diphtheria Toxoid Conjugate Vaccine (NmVac4-A/C/Y/W-135-DT™) Compared With A Licensed Vaccine PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the production of antibodies to a new conjugate vaccine, NmVac4-A/C/Y/W-135-DT, as a measure of vaccine effectiveness, compared to the production of antibodies to a similar, licensed meningococcal (Groups A, C, Y, W-135) polysaccharide diphtheria toxoid (DT) conjugate vaccine. The investigators will also evaluate the safety of NmVac4-A/C/Y/W-135-DT™ conjugate vaccine compared to the licensed vaccine. The hypothesis is that the test vaccine is comparable to the licensed active control vaccine. |
ALBERTO YATACO; | 2013-07-01 |
| 325 | Umbilical Cord Care for The Prevention of Colonization PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Umbilical catheters are necessary for many infants admitted to the Newborn Intensive Care Unit (NICU)and utilized when indicated for up to 7 to 14 days. Bacterial colonization can occur at the umbilical stump and potentially lead to serious bloodstream infections (BSIs). This study is a prospective, randomized controlled feasibility trial to evaluate three types of hygiene products on umbilical line stumps, on the effect of line colonization and subsequent infections. Infants admitted to the NICU with an umbilical line(s) will be randomized into one of four study groups, … |
DAVID A KAUFMAN; | 2013-07-01 |
| 326 | Nervous System Infections Among Patients With Febrile Seizure : Retrospective Cohort Review of Consecutive Patients Admitted in 7 Pediatric Emergency Departments in Ile-de-France Between 2007 and 2011 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Few studies dealing with the risk of infectious of nervous system and the utility of lumbar puncture and of emergent neuroimaging among patients with simple febrile seizure between 3 and 11 months age and with complex seizure has been reported. None of these studies was multicentric. Recommendations about management of these children are heterogeneous. The investigators aim to study by an observational retrospective multicentric study the rate of infectious of central nervous system among patients with a complex febrile seizure and among patients between 3 and 11 months age with simple febrile seizure. |
RICARDO CARBAJAL; | 2013-06-01 |
| 327 | A Prospective Cohort Study Evaluating Prognostic Indicators and Sequelae Following Severe Hand Foot and Mouth Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hand Foot and Mouth Disease (HFMD) is a common infectious disease in childhood. Several enteroviruses are associated with the disease. However, since 1997, large outbreaks of HFMD in Taiwan, Malaysia and Vietnam have seen unusual neurological complications such as brainstem encephalitis with rare fatal outcomes. The pathogen associated with this severe disease is Enterovirus 71. In 2011, Vietnam had a large outbreak of Hand Foot and mouth disease resulting in 110,000 cases and 164 deaths. HFMD affects children during their early years of child development, … |
SARASWATHY SABANATHAN; | 2013-06-01 |
| 328 | Explorative PK Study Comparing 600 Mg Rifampicin I.v. With 750 Mg and 900 Mg Rifampicin Oral in Tuberculous Meningitis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculous (TB) meningitis is the most severe manifestation of TB infection, leaving up to 50% of patients dead or neurologically disabled. Current treatment is similar to treatment of lung TB, although penetration of some antibiotics into the brain is poor and the immune-pathology of TB meningitis is very different from pulmonary TB. In a recent phase II clinical trial from the investigators group, the first of its kind globally, intensified antibiotic treatment, with moxifloxacin and high dose rifampicin, … |
ROVINA RUSLAMI; | 2013-06-01 |
| 329 | A New Cochlear Implant Electrode With A Cork Type Stopper For Inner Ear Malformations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The custom made device was produced by Med-El Company. It has a cork like stopper instead of the usual silicon ring to prevent gusher. There are two types of electrodes consisting of different length. Standard one is 25 mm (contact space 1.7 mm) and the short one is 20 mm (contact space 1.3 mm). It was used in 50 patients with different inner ear malformations. Thirteen patients had gusher, … |
MÜNIR DEMIR BAJIN; | 2013-05-01 |
| 330 | Study of The Nucleus 24 and ABI541 Auditory Brainstem Implants in Pediatric Non-Neurofibromatosis Type 2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to determine whether Auditory Brainstem Implant (ABI) can improve hearing in children who are deaf and cannot receive a cochlear implants. |
DANIEL LEE; | 2013-05-01 |
| 331 | A Comparative, Randomised Controlled Trial for Evaluating The Efficacy of Dexamethasone in The Treatment of Patients With Acute Respiratory Distress Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND: Currently, there is no proven pharmacologic treatment for patients with the acute respiratory distress syndrome (ARDS). Great interest remains in the use of corticosteroids for the salvage of patients with severe acute lung injury in the early phase of their disease process, … |
JESUS VILLAR; | 2013-03-28 |
| 332 | Bacterial Meningitis in Adults: Analysis of The Determinants of Mortality and Neurosensory Sequelae PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Major changes in the epidemiological characteristics of bacterial meningitis have been observed as a result of changes in behaviour, human interventions (use of antibiotics, prophylactic vaccinations), as well as poorly elucidated mechanisms responsible for epidemic outbreaks. The objective of this study is to identify the determinants of in-hospital mortality of bacterial meningitis in adults. Hypothesis : the standardized data collection concerning cases of bacterial meningitis in adults with telephone follow-up would allow analysis of the determinants of mortality and neurosensory sequelae, description of the psychosocial impact and proposal of new treatment strategies. |
XAVIER DUVAL; | 2013-03-01 |
| 333 | Improving The Diagnosis of Meningitis in Emergency Rooms PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A point-of-care laboratory (POC) was set at North Hospital, Marseille, France for the diagnosis in less than two hours of meningitis caused by known pathogens, close to the reception of Emergency service. In this instance 30% of patients have no etiological diagnosis after the POC diarrhoea tests . This lab has discovered over 200 new species of bacteria in humans, including vector bacteria and opened the field of large Deoxyribonucleic Acid (DNA ) viruses. Also, the laboratory of emerging viruses discovered many Ribonucleic Acid (RNA) viruses transmitted by arthropods. Based on this collection of new pathogens described in POC laboratory, … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2013-02-01 |
| 334 | A Phase II Study of Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Completely Acute Spinal Cord Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to assess the safety and effect of autologous adipose derived stem cell (ADSCs) transplantation in acute spinal cord injury patients. 1. To assess the safety of autologous ADSCs transplantation in acute spinal cord injury and the complication after ADSCs transplantation. 2. To evaluate the effect of ADSCs isolation and expansion procedure. 3. To determine if functional outcome is improved following ADSCs transplantation in acute spinal cord injury patient, using pre-transplantation spinal cord function as the control. |
PHUC BA DUONG; | 2013-02-01 |
| 335 | A Single-arm, Open-label Study To Describe The Safety, Tolerability, And Immunogenicity Of Bivalent Rlp2086 Vaccine In Laboratory Workers >=18 To < =65 Years Of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the safety, tolerability and immunogenicity of bivalent rLP2086 vaccine in laboratory workers ≥18 to ≤65 years of age administered on a Month 0, 2, and 6 schedule. The study will recruit laboratory personnel (inclusive of Pfizer staff) who work directly with pathogenic Neisseria meningitidis in the context of the bivalent rLP2086 vaccine development program. The study will provide descriptive safety and immunogenicity data following vaccination of these individuals with bivalent rLP2086 vaccine. |
PFIZER | 2013-02-01 |
| 336 | A Phase 3, Randomized, Double-Blind, Multi-Center Study to Compare The Efficacy and Safety of Micafungin Versus Amphotericin B Deoxycholate for The Treatment of Neonatal Candidiasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will evaluate how effective and how safe the drug micafungin is when compared to the drug amphotericin B deoxycholate in treating neonates and young infants with certain fungal infections. |
ASTELLAS PHARMA GLOBAL DEVELOPMENT | 2013-02-01 |
| 337 | Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days of Age (Inclusive) With Probable and Confirmed Meningitis: A European Multicenter Phase I-II Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase I-II multicenter international trial is designed to study the pharmacokinetics of meropenem and to characterize the safety profile of meropenem in the treatment of infants ≤ 90 days of postnatal age with probable or confirmed bacterial meningitis. |
PAUL HEATH; | 2013-02-01 |
| 338 | Validation of A Vital Signs and Symptoms Decision Tree and The Effect of A Point-of- Care CRP Test, Oxygen Saturation, A Brief Intervention and A Parent Leaflet on Diagnosing, Antibiotic Prescribing Rate and Parental Satisfaction in Acutely Ill Children in Primary Care. PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity, mortality, induced fear in parents and defensive behaviour in clinicians). Early recognition and adequate referral of serious infections are essential to avoid complications (e.g. hearing loss after bacterial meningitis) and their accompanied mortality. Secondly, we aim to reduce the number of investigations, referrals, treatments and hospitalisations in children who are diagnosed with a non-serious infection. Apart from the cost-effectiveness, … |
JAN VERBAKEL; | 2013-01-01 |
| 339 | Therapeutic Monitoring of Ceftriaxone, Prescribed at High Doses, in The Treatment of Meningitis and Others Neurological Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to describe the concentrations of Ceftriaxone at the steady state, in patients treated for meningitis, to determine pharmacokinetic parameters at high dose in this population. Additionally, we aimed to detect adverse effect, especially neurological trouble related to Ceftriaxone toxicity. |
NANTES UNIVERSITY HOSPITAL | 2012-12-01 |
| 340 | A Single Centre, Open-label, Randomised Clinical Study to Investigate Meningococcal Serogroup A and C Saccharide Specific B Cell Responses in Adult Volunteers to One of Three Regimens of Meningococcal ACWY Conjugate Vaccine or Meningococcal ACWY Polysaccharide Vaccine Priming Doses Followed By A Booster Dose of The Meningococcal ACWY Conjugate Vaccine PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The bacterium (germ) Neisseria meningitidis causes meningitis and blood poisoning. N meningitidis is classified into different serogroups (types), based on its outer polysaccharide (carbohydrate) capsule. Serogroups A,B,C,W & Y are responsible for the vast majority of meningococcal disease worldwide. Older vaccines against types A,C,W & Y contain part of the polysaccharide capsule of the germ. However, these polysaccharide vaccines do not provide long-term protection against disease and are less effective in young children, the group most at risk of meningococcal disease. Newer conjugate ACWY vaccines attach a polysaccharide to a protein carrier – … |
ANDREW J POLLARD; | 2012-12-01 |
| 341 | Study of The Digestive Colonization of The Newborn Children By The Streptococcus of The Group B PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study : Demonstrate that GBS (group B streptococci) ST-17 colonize and persist to 60 days twice in the digestive tract of newborns that strains of GBS non-ST-17. Secondary objectives:Determine: – The frequency of colonization with GBS ST-17 and GBS non-ST-17 of at risk pregnant women. – The frequency of colonization of neonates by GBS ST-17 at birth. – The preferential site of colonization in the mother (rectum, vagina, breast milk). – The kinetics of colonization after birth in the newborn. – … |
CLAIRE POYART; | 2012-11-12 |
| 342 | Multicenter, Open-label, Historically Controlled, Phase III Study to Assess The Efficacy, Tolerability, Safety and Pharmacokinetics of Kedrion IVIG 10% in Adult and Pediatric Subjects With Primary Immunodeficiency (PID) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether Kedrion IVIG 10% (an immunoglobulin solution) is effective in treating Primary Immunodeficiency (PID). |
KEDRION S P A | 2012-11-12 |
| 343 | Phase I/II Trial Evaluating The Safety and Efficacy of Ruxolitinib in Subjects With Smoldering and Chronic Adult T-cell Leukemia (ATL) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: – The human T-cell leukemia virus 1 (HTLV-1) causes adult T-cell leukemia (ATL). Infection does not immediately cause ATL, but it can develop over time. ATL is a rare and aggressive type of cancer that disrupts the body’s ability to control the HTLV-1 virus. Infected T lymphocytes that are transformed by HTLV-1 into malignant ATL cell have constitutively activated Interleukin-2 (IL-2), IL-9 and IL-15 production pathways that function as autocrine and paracrine stimulators of these cells by stimulating these cells through the Janus Kinase (JAK) 1 and 3/Signal transducer and activator of transcription 5 (STAT5) pathways. – … |
KEVIN CONLON; | 2012-10-26 |
| 344 | Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for The Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The impact of neurological disorders is enormous worldwide, and it is increased in poor settings, due to lack of diagnosis and treatment facilities as well as delayed management. In sub-Saharan Africa, the few observational studies conducted for the past 20 years show that neurological disorders accounted for 7 to 24% of all admissions. Central nervous system (CNS) infections were suspected in one third of all patients admitted with neurological symptoms, with a specific microbial aetiology identified in half of these. Most CNS infections may be considered as severe and treatable diseases, e.g. human African trypanosomiasis (HAT), cerebral malaria, bacterial meningitis, … |
INSTITUTE OF TROPICAL MEDICINE BELGIUM | 2012-09-01 |
| 345 | A Double-Blind, Randomized Controlled Trial of Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the effectiveness of a needle-free jet-injection system with 1% buffered lidocaine for local anesthesia for lumbar punctures compared to a topical anesthetic agent. Our hypothesis is: A needle-free jet-injection system (J-Tip) with 1% lidocaine will provide local anesthesia that is comparable to that of a topical anesthetic agent (EMLA cream) when performing lumbar punctures in children. |
RYAN CALTAGIRONE; | 2012-09-01 |
| 346 | Susceptibility to Infections in Patients With Ataxia Telangiectasia : A Prospective Follow-up Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Death in Ataxia telangiectasia (A-T) is usually due to cancer or chronic lung failure around 20 years of age. Despite low lymphocyte counts (CD3, CD4, CD8 and CD19), IgA and IgG subclass deficiency opportunistic and acute severe respiratory infections are rare. The prevailing wisdom is that an immunoglobulin replacement therapy is not necessary in most of the patients. However no placebo controlled trials have been performed so far. The aim of this trial was to investigate the prevalence of mild and severe respiratory infections and / or chronic cough in classical A-T patients compared to healthy controls. |
STEFAN ZIELEN; | 2012-09-01 |
| 347 | A Phase I, Single Centre, Open-label Dose-escalation Study to Assess The Safety and Immunogenicity of Three Doses of 25µg or 50 Μg of Meningococcal Serogroup B Outer Membrane Vesicle Vaccine MenPF-1 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study the investigators are testing a new vaccine against Neisseria meningitidis, the leading infective cause of childhood death in the UK. This bug (also known as meningococcus) can infect the lining of the brain (meningitis) or the blood stream (septicaemia) and can affect all ages, but especially children, adolescents and young adults. The bug is classified into different groups based on its outer capsule (or shell), and this study will test a new vaccine to protect against group B meningococcus (MenB) disease, … |
ANDREW J POLLARD; | 2012-08-01 |
| 348 | Early Vitamin D Supplementation for Prevention of Respiratory Morbidity in Extremely Preterm Infants: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study hypothesis states that giving early enteral Vitamin D supplementation to preterm infants will decrease respiratory morbidity in extremely preterm infants. |
NAMASIVAYAM AMBALAVANAN; | 2012-06-01 |
| 349 | A Double-blind,Randomized,Parallel,Placebo-controlled Study of Probiotics Capsule As Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: B streptococcal infection and the major cause of death before and after the baby is born. B streptococcus infection the way of the newborn, usually infection from the mother in childbirth, if the pregnant women during pregnancy early diagnosis B streptococcus infection, it can be effective in preventing the risk of neonatal infection. Department of Health in China has been since April 15, 2012, the Scholarship holder at all pregnant women in the 35-37 weeks of pregnancy comprehensive B streptococcus screening. Infection B Streptococcus pregnant women in the labor process, … |
MENG-HSING WU; | 2012-06-01 |
| 350 | Prospective Pilot Study to Evaluate A Standardized Management of Cryptococcal Meningitis in Patients Infected With HIV in Sub-Saharan Africa Involving An Initial Combination Therapy With Fluconazole and Flucytosine in High Doses, Complemented By Repeat Lumbar Punctures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the trial is to demonstrate that in a sub-Saharan African setting, the association of: 1. Oral treatment : high dose of fluconazole (1600mg/d) associated with flucytosine (100 mg/kg/j) as induction therapy 2. lumbar punctures to control intracranial pressure can decrease mortality rate below 35% at 10 weeks. This is a non-randomized open label pilot study, with standardized management of cryptococcoses meningitis and follow-up in Burundi and Ivory Coast. A total of 41 patients will be enrolled. |
AMÉLIE CHABROL; | 2012-05-01 |
| 351 | WEUSKOP6166: Prevalence of Aseptic Meningitis Among Lamotrigine Users Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to quantify the number of cases of aseptic meningitis among users of Lamotrigine. This study is a cross-sectional study design using data on lamotrigine patients within the Thomson Reuters MarketScan® Commercial database (MarketScan database). The MarketScan database is a US-based insurance claims database representative of a US insured population and includes supplemental datao n Medicare patients. This cross-sectional study will evaluate the number of cases of aseptic meningitis among lamotrigine users during the duration of lamotrigine therapy, … |
GLAXOSMITHKLINE | 2012-05-01 |
| 352 | An Alternative Booster Vaccine Against Meningitis and Ear Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to evaluate an alternative booster for pneumococcal conjugate vaccination (PCV) for children at 12 months of age. Currently in the UK, 3 doses of a vaccine called Prevenar 13 (PCV-13), which contains 13 pneumococcal serotypes attached to a carrier protein called CRM197, are given to children at 2, 4 and 12 months of age. There is some evidence that a vaccine called Synflorix (PHiD-CV) may be at least as good as the currently used vaccine when used as an alternative vaccine at 12 months of age. Although PHiD-CV contains only 10 serotypes, … |
ANDREW POLLARD; | 2012-04-01 |
| 353 | Evaluation of Cerebrospinal Fluid Concentration of Daptomycin (Cubicin¬) in Pediatric Patients With Gram-positive Bacterial Meningitis, Concurrently Receiving Standard Antimicrobial Therapy Related Papers Related Patents Related Grants Related Experts View Highlight: 5 Children > 3months and < 16 years with Gram-positive meningitis will receive a single dose of daptomycin 24 hours after the first dose of ceftriaxone. 4-8 hours after daptomycin administration a second lumbar puncture is performed to determine the peak concentration of daptomycin in the cerebrospinal fluid. In parallel peak and trough level of daptomycin will be measured in the plasma. The investigators anticipate that daptomycin penetrates into the cerebrospinal fluid in bactericidal concentrations |
PHILIPP AGYEMAN; | 2012-04-01 |
| 354 | Predictive Biomarkers of Mortality and Morbidity in Children Hospitalized for Acute Febrile Illness PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to identify clinically informative biomarkers of host defense pathways with potential utility as diagnostic and prognostic tools among children hospitalized with acute febrile illness in a resource-constrained sub-Saharan African setting. The working hypothesis is that a panel of biomarkers, readily measurable from a peripheral blood sample, may serve as a clinically useful instrument to distinguish between common pediatric causes of fever, predict those children at greatest need of aggressive supportive care and/or adjunctive therapies, … |
MICHAEL T HAWKES; | 2012-02-01 |
| 355 | Slow Initial Β-lactam Infusion With High-dose Paracetamol to Improve The Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this trial is to test if mortality of childhood bacterial meningitis can be reduced by slow, continuous infusion of cefotaxime initially, instead of the traditional bolus administration four times daily (qid), combined with high-dose paracetamol orally, when both treatments are executed for the first 4 days. The series will be collected at Hospital Pediátrico David Bernardino, Luanda, Angola. The recruitment of patients begins, the conditions permitting, … |
HEIKKI PELTOLA; | 2012-02-01 |
| 356 | A Case-control Study of The Efficacy of A New Serogroup A Meningococcal Conjugate Vaccine (MenAfriVac) in Mali and Niger Related Papers Related Patents Related Grants Related Experts View Highlight: Major epidemics of meningococcal meningitis occur in countries of the African Sahel and sub-Sahel every few years. Most of these epidemics are caused by meningococci belonging to serogroup A. Until recently there has been no serogroup A conjugate vaccine available to prevent epidemics in Africa because none of the major pharmaceutical companies wanted to develop such a vaccine for commercial reasons. For this reason a public private partnership was established in 2001, the Meningitis Vaccine Project (MVP), with support from the Bill and Melinda Gates Foundation, … |
BRIAN GREENWOOD; | 2012-02-01 |
| 357 | Individualizing Duration of Antibiotic Therapy in Hospitalized Patients With Community – Acquired Pneumonia: A Non-inferiority, Randomized, Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess the efficacy of an individualized approach to duration of antibiotic therapy based on each subject’s clinical response compared to a local standard approach in patients coming from the community and who are hospitalized because of a pneumonia. |
FRANCESCO BLASI; | 2012-01-01 |
| 358 | Will The Use of Osteopathic Manipulative Treatments on Patients With Headache in The Emergency Department Result in Decreased Pain on 100 Point Pain Scale? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: PURPOSE The purpose of this research is to determine whether osteopathic manipulative therapy (OMT) is a useful adjunct in evaluation and treatment of headaches. PROCEDURES If a practitioner determines that a patient has a significant headache he/she may order tests. He/ She may give the patient medications to treat the headache. The investigators will also ask permission to evaluate and treat the headache using osteopathic evaluation and Osteopathic Manipulative Treatment (OMT). The bedside evaluation and treatment will be performed by an emergency medicine resident. Osteopathic evaluation and OMT is not standard of care for this condition. The investigators also may call the patient in 7 days to see how they are doing. The investigators wish to see if emergency medicine physicians can use osteopathic evaluation and OMT to reliably treat headaches. The results of the examination and treatment will be recorded, but will not be used to change treatment or to change additional tests. The investigators wish to see whether in the future they can use OMT in certain cases instead of or in conjunction with medications. The investigators plan on asking 50 patients to participate. |
GENEVIEVE MCGERALD; | 2012-01-01 |
| 359 | Efficacy of Phenytoin in The Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. A Multi-center Comparative Randomized Double-blind and Placebo-controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy of the prophylaxis with phenytoin in the prevention of seizures in patients with pneumococcal meningitis. Hypothesis: Administration of prophylactic phenytoin will reduce the incidence of seizures in patients with pneumococcal meningitis older than 50 yrs. |
M. CARMEN CABELLOS MINGUEZ; | 2011-11-01 |
| 360 | A Double-Blind, Randomized, Controlled, Two Arm Phase 1 Clinical Trial of The Safety and Immunogenicity of Group A, C, Y & W-135 Meningococcal Polysaccharide DT Conjugate Vaccine: NmVac4-A/C/Y/W-135-DT™ PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety of a new conjugate vaccine, NmVac4-A/C/Y/W-135-DT, compared to the safety of a similar, licensed meningococcal A/C/Y/W-135-DT conjugate vaccine. The investigators will also evaluate the production of antibodies to of NmVac4-A/C/Y/W-135-DT™ conjugate vaccine compared to the licensed vaccine, as a measure of vaccine effectiveness. |
SUDESH NAGAVALLI; | 2011-11-01 |
| 361 | Safety and Immunogenicity of 23-valent Pneumococcal Polysaccharide Vaccine in 2 to 70 Years Old Healthy People in China PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococcal infection is a leading cause of death throughout the world and a major cause of pneumonia, bacteremia, meningitis, and otitis media. It has been established that purified pneumococcal capsular polysaccharides induce antibody production and such antibody is effective in preventing pneumococcal disease. Clinical studies have demonstrated the immunogenicity of each of the 23 capsular types when tested in polyvalent vaccines. Studies of 23-valent pneumococcal vaccine in children of two years old and older and in adults of all ages have showed immunogenic response. In order to provide more evidence for the immunogenicity and the safety of the vaccine, … |
JIANGSU PROVINCE CENTERS FOR DISEASE CONTROL AND PREVENTION | 2011-10-01 |
| 362 | A Multicenter Study of Long-Term Clinical Outcomes of Immune Globulin Subcutaneous (Human) (SCIG) IgPro20 in Subjects With Primary Immunodeficiency PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the long-term efficacy, tolerability, and safety of IgPro20 in subjects with primary immunodeficiency (PID) as an extension to the preceding follow-up study ZLB07_001CR (NCT01458171). |
CSL BEHRING | 2011-10-01 |
| 363 | A Phase 2, Randomized, Active-controlled, Observer-blinded Trial, To Assess The Safety, Tolerability, And Immunogenicity Of Gardasil (Registered) (Hpv) Vaccine And Bivalent Rlp2086 Vaccine When Administered Concomitantly In Healthy Subjects Aged >=11 To <18 Years PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a clinical study to assess the safety, tolerance and immunogenic response to Gardasil (human papilloma virus (HPV)) and rLP2086 vaccine. Healthy male and female subjects will be randomized into 1 of 3 groups; the trial will be an observer-blinded study to the injection being given; and, vaccinated with either Gardasil and rLP2086 concomitantly, rLP2086 and saline concomitantly, or Gardasil and saline concomitantly. The subjects are adolescent children between the ages of 11 and 17 years old. |
PFIZER | 2011-09-28 |
| 364 | A Phase IV Study to Assess The Safety of Menveo Vaccine Being Used By HMO Subjects Aged 11-21 Years of Age PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this US FDA post-marketing commitment study is to evaluate the safety of MenACWY-CRM among 50.000 vaccinated adolescents within a large US Healthcare Maintenance Organization who received MenACWY-CRM vaccination as part of their routine clinical care. The pre-specified 26 events of interest are events commonly evaluated in vaccine safety studies and include certain neurological, immunological, vascular, musculoskeletal and hematologic disorders. All events are collected retrospectively. |
NOVARTIS VACCINES | 2011-09-01 |
| 365 | Evaluation of A Structured Algorithm for Intrathecal Bolus Doses of Ziconotide (Prialt®)- The Swedish Ziconotide Bolus Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate if the effect of ziconotide can be tested by intrathecal bolus doses. |
EMMANUEL BACKRYD; | 2011-08-01 |
| 366 | Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in The Treatment of Acute Exacerbations of Asthma in Children Who Attend The Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A trial to investigate if a single dose of the oral corticosteroid, Dexamethasone is as effective in treating exacerbations of asthma in children as 3 days of treatment with another oral corticosteroid, Prednisolone |
UNIVERSITY COLLEGE DUBLIN | 2011-07-06 |
| 367 | A Clinical Study of Immune Globulin Subcutaneous (Human) (IGSC), 20% for The Evaluation of Efficacy, Safety, and Pharmacokinetics in Subjects With Primary Immunodeficiency Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to develop a 20% subcutaneous immunoglobulin treatment option for patients with primary immunodeficiency (PID) diseases. |
BAXALTA NOW PART OF SHIRE | 2011-06-20 |
| 368 | Chinese Medicinal Treatment on Mild Hand, Foot, and Mouth Disease: Multicenter, Prospective, Randomized Double-blind, Placebo-controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is aimed to evaluate the effectiveness and safety of Jinlianqingre Effervescent Tablets, a traditional Chinese medicine (TCM), in the treatment of Uncomplicated hand, foot, and mouth disease (HFMD). |
LIYUN HE; | 2011-06-01 |
| 369 | A Randomized, Double-Blind, Multicenter, Parallel-Group Comparative Phase III Study Evaluating The Efficacy and Safety of TAK-816 Compared With ActHIB in Healthy Infants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy (immunogenicity) of TAK-816 when administered to healthy Japanese infants as multiple subcutaneous doses. |
TAKEDA | 2011-06-01 |
| 370 | Phase 1-2 Study of Safety and Efficacy of Intrathecal Trastuzumab Administration in Metastatic HER2 Positive Breast Cancer Patients Developing Carcinomatous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is: Phase I: To determine the Trastuzumab maximum tolerated dose (MTD) when weekly administrated by intrathecal or intraventricular route to reach a intra CSF target concentration (30 µg/mL) near the conventional therapeutic concentration and depending on the dose-limiting toxicity (DLT) Phase II: Determination of antitumor activity trastuzumab when administrated by IT or intra-ventricular in terms of neurological progression-free survival at 2 months |
INSTITUT CURIE | 2011-05-19 |
| 371 | Oral Probiotics Lactobacillus Rhamnosus GR-1 and Lactobacillus Reuteri RC-14 Reduce Group B Streptococci Colonization in Pregnant Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine whether daily use of oral gelatin capsules containing dried viable Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 can reduce the GBS colonization rate of vagina and rectum in pregnant women who present with GBS-positive diagnosed by GBS culture at 35-37 weeks gestation. This study is a prospective double blind randomized clinical trial. Vaginal and rectal GBS screening culture are carried out for all pregnant women at 35-37 weeks of gestation in our out-patient department. Subjects with vagina and rectum GBS colonization are invited to participate in our study after informed consent. A total of 200 pregnant women will participate in the study during the 12-months trial period. They are randomly assigned to one of the two groups. The study group is treated with two oral capsules of probiotics once daily (before sleeping) for 14 days, and the control group will take 2 capsules of placebos. Vaginal and rectal GBS culture is repeated for all participators 2 weeks later. All participators will treated according to GBS guideline by CDC in 2002 during laboring. |
CHINA MEDICAL UNIVERSITY HOSPITAL | 2011-04-01 |
| 372 | Intracranial Hypertension Detection Using Optic Nerve Sheath Diameter Measurement in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Intracranial hypertension (ICH) is a mortality risk factor in severe traumatic brain injury (TBI), in purulent meningitis, in hepatic encephalopathy and in Reye’s syndrome. It is also a risk factor for severe neurologic sequelae in survivors. Intracranial pressure (ICP) monitoring is likely to guide therapeutics, and certain research on adults or on children, suggest that IH therapeutic approach, for instance for bacterial meningitis, would improve the prognosis. Two monitoring techniques are currently recommended. They are reference methods for ICP measure : – monitoring with intraventricular catheter, – intra-parenchymal monitoring using optical fiber catheter. Non invasive methods have been suggested, … |
ETIENNE JAVOUHEY; | 2011-04-01 |
| 373 | Computerized Cognitive Rehabilitation in Children After Severe Malaria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Brain training exercises will be provided to children who survived an episode of severe malaria. These children will be given assessments for cognition, behaviour and executive functions before and after the brain training exercises. |
MICHAEL J BOIVIN; | 2011-04-01 |
| 374 | Continuation of The Costa Rican Epidemiologic Surveillance for Invasive Pneumococcal Disease After Introduction of The Seven Valent Vaccine Into The Universal Vaccination Program PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Streptococcus pneumoniae is a major cause of pneumonia, sepsis, bacteremia and pneumococcal meningitis among infants and children worldwide. Knowledge of the epidemiology of pneumococcal disease is essential to assess the potential usefulness of pneumococcal disease usefulness of pneumococcal conjugate immunization. There is a paucity of information regarding pneumococcal disease burden in children in Latin America. Most studies are based on passive microbiology laboratory surveillance that does not capture all invasive disease, thus underestimating the true disease burden. Data from an active surveillance is available from an specific region in Costa Rica, … |
ARTURO ABDELNOUR; | 2011-03-01 |
| 375 | Overcoming Membrane Transporters to Improve CNS Drug Delivery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall purpose of this research study is to investigate the safety of pharmacological therapies that may potentially improve pediatric outcomes after traumatic brain injury. Traumatic brain injuries are the leading cause of death and disability among children and young adults. Hypothesis: Combinational therapy with a membrane transporter and antioxidant are safe after TBI and can overcome barriers to the brain and synergistically improve bioavailability and efficacy the antioxidant content of the body and CNS after TBI. |
ROBERT CLARK; | 2011-03-01 |
| 376 | Antibiotic Prophylaxis for Early Ventilator-associated Pneumonia in Neurological Patients: A Randomized Trial Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to assess whether coma patients really benefit from the use of antibiotics as a prophylactic for reducing the incidence of early ventilator-associated pneumonia in this population group. For this we consider the use of ampicillin sulbactam antibiotic which has a low ability to induce resistance, efficacy and safety observed during the time that has been used, even in patients with neurosurgical pathology, and to be broadly available in our environment. Our hypothesis is that neurological patients in coma state, requiring mechanical ventilation, the application of antibiotic prophylaxis compared with placebo reduces the incidence of early ventilator-associated pneumonia. |
CARLOS A CADAVID; | 2011-03-01 |
| 377 | Lumbar Drain After Endoscopic Surgery of The Skull Base PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall purpose of this study was to assess the necessity of lumbar drain placement after endoscopic endonasal approach (EEA) surgery in reducing cerebrospinal fluid (CSF) leak postoperatively and promote a standardization of its use. |
PAUL GARDNER; | 2011-02-03 |
| 378 | Validation of Vital Signs and Symptoms for The Diagnosis of Serious Infections in Children in A High Prevalent Setting: The Paediatric A&E PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Validation of Vital Signs and Symptoms for the Diagnosis of Serious Infections in Acutely Ill Children in a High Prevalent Setting: The Paediatric Accidents & Emergencies through prospective observational data collection concerning specific items from the clinical and technical examination in diagnosing serious infections, such as meningitis, sepsis, pneumonia, pyelonephritis, bronchiolitis with hypoxia. Eventually we will attempt to validate a vital signs and symptoms rule derived from multiple low to high prevalent settings of acutely ill children. |
JAN VERBAKEL; | 2011-02-01 |
| 379 | Phase I Randomised Multi-centre Study to Demonstrate The Safety of WBRT Concomitant to Intrathecal Liposomal Cytarabine (DepoCyte®) Versus WBRT & Sequential Intrathecal Liposomal Cytarabine (DepoCyte®) for Treatment of STNM With or Without Brain Metastasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to demonstrate the safety of giving Whole Brain Radiotherapy (WBRT) together with intrathecal liposomal cytarabine (DepoCyte®) for patients with leptomeningeal metastases. The study will compare the safety of giving DepoCyte at the same time as WBRT with giving the drug after WBRT is complete. |
MUNDIPHARMA RESEARCH | 2011-02-01 |
| 380 | A Randomized Study to Evaluate The Safety and Efficacy of Liposomal Amphotericin B and Amphotericin B Deoxycholate With or Without Flucytosine Followed By Fluconazole, for The Treatment of Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and efficacy of liposomal amphotericin B and amphotericin B deoxycholate with or without flucytosine followed by fluconazole for the treatment of cryptococcal meningitis. |
YEE-CHUN CHEN; | 2011-02-01 |
| 381 | New Protocol for Identification of Serious Bacterial Infection in Febrile Newborn PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of present study was to evaluate clinical and laboratory characteristics of febrile neonate and describe the incidence of SBI in febrile neonates. Secondarly investigators aimed to test usefulness of major protocols and new protocol in evaluating only febrile neonate. |
ALI BULBUL; | 2011-01-01 |
| 382 | EARLYdrain – Prospective Outcome Study of Early Lumbar Drainage in Aneurysmal Subarachnoid Hemorrhage PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The intention of the study is to investigate whether drainage of cerebral spinal fluid via a lumbar route (Tuohy-drain) will improve outcome after intracranial aneurysmal subarachnoid hemorrhage (SAH). |
STEFAN WOLF; | 2011-01-01 |
| 383 | Institutional Review Board Application #13373, Entitled A Randomized Clinical Trial of Pediatric Lumbar Puncture Success Using The Compass, A Compact Quantitative Pressure Transducer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: To evaluate pediatric emergency department provider lumbar puncture success with and without the Compass Lumbar Puncture Enhanced, a new pressure transducer, in order to determine: the proportion of lumbar punctures where a) any cerebrospinal fluid is obtained on the first attempt, b) any cerebrospinal fluid is obtained on any attempt, and c) sufficient cerebrospinal fluid is obtained for standard tests (culture, chemistries, cell count); the time to provider success in obtaining a) a drop of fluid from the needle, and b) opening pressure measurement; the proportion of successful lumbar punctures that contain blood; … |
JULIE C. BROWN; | 2011-01-01 |
| 384 | A Randomized, Non-inferiority, Active Controlled Clinical Trial to Evaluate The Safety and Efficacy of Ciprofloxacin Versus Doxycycline in The Treatment of Plague in Humans PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Plague is a severe, life-threatening disease. Plague occurs in focal locations worldwide, but over 95% of human cases reported to WHO are by countries in Africa. The most common clinical manifestations of human infection are bubonic, septicemic, and pneumonic plague. Untreated pneumonic or septicemic plague is fatal in over 90% of cases; untreated bubonic plague is fatal in over 50% of cases. Delayed and ineffectual treatment is a main contributor to elevated case fatality rates, which can be as high as 40%, and to the development of pneumonic plague and plague outbreaks. Streptomycin is considered the treatment of choice, … |
KEVIN S. GRIFFITH; | 2010-12-01 |
| 385 | Phase 2, Observer Blinded, Controlled, Randomized Multi-Center Study in Adolescents, to Evaluate Safety, Tolerability and Immunogenicity of Four Different RMenB Plus MenACWY Formulations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this phase 2 study is to evaluate the safety, tolerability and immunogenicity of two doses of 4 different investigational MenABCWY combination vaccine when administered to healthy adolescents aged 11-18 years. |
NOVARTIS VACCINES | 2010-12-01 |
| 386 | Use of A New Rapid Method, BioNanoPore, for Growth and Detection of Group B Streptococcus in Pregnant Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the use of a new method of growing and detecting Group B streptococcus in pregnant women. This new method utilizes sandwiched-membrane petri technology and has the advantage of detecting GBS in less than 6 hours, with less cost, and the potential of allowing antibiotic sensitivities to be performed. |
JONATHAN P FARO; | 2010-11-01 |
| 387 | Trial for The Optimal Timing of HIV Therapy After Cryptococcal Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Cryptococcal Optimal ART Timing (COAT) trial seeks to determine after cryptococcal meningitis (CM) whether early initiation of antiretroviral therapy (ART) prior to hospital discharge results in superior survival compared to standard initiation of ART started as an outpatient. |
DAVID R BOULWARE; | 2010-11-01 |
| 388 | Copeptin for Risk Stratification in Non-traumatic Headache in The Emergency Setting – The CoHead Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Headache is a common symptom, and patients often seek medical attention at emergency departments due to headaches. The aim of the CoHead Study is to find out if it is possible by measuring copeptin, a marker of stress in the blood, to find out which patients have simple headaches and which patients have dangerous headaches that are the symptom of an underlying disease and need further investigation and treatment. Copeptin is a marker for physical stress and has been tested in patients with stroke, heart attack and pneumonia. In all these illnesses, … |
MIRJAM CHRIST-CRAIN; | 2010-10-01 |
| 389 | Comparison of Intensive Treatment Regimens and Standard Treatment Regimen for Tuberculous Meningitis: Pharmacokinetics, Pharmacodynamics and Tolerability Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculous meningitis (TBM) is the most lethal form of tuberculosis infection, and is diagnosed in approximately 5-10% of TB patients. The incidence of TBM has increased considerably during the last decade, partly due to the HIV epidemic. Without treatment, virtually all patients with TB meningitis will die. With the current treatment regimens, TBM is fatal in approximately 30-50% of cases, and responsible for severe disability in a similar proportion of survivors. Worldwide, Indonesia the third highest case load of tuberculosis with an estimated 500,000 new patients / year. Representative data are lacking, … |
AHMAD RIZAL GANIEM; | 2010-10-01 |
| 390 | Diagnosis of Tuberculous Meningitis By A Secretory Antigenic Target 6 (ESAT-6) in CSF PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Early and reliable diagnosis of tuberculous meningitis (TBM) still poses a great challenge. One of the underlying difficulties is due to the fact that tubercle bacilli are mainly not present in the cerebrospinal fluid (CSF) but in the phagocytotic macrophages. The present study was designed to demonstrate early secretory antigenic target 6 (ESAT-6), a mycobacterium-specific antigens, in the macrophages in infected CSF samples and compare the efficiency of this antigen in the laboratory diagnosis of TBM. |
XIJING HOSPITAL | 2010-09-01 |
| 391 | The Role of Short-course Ceftriaxone Therapy in The Treatment of Severe Nontyphoidal Salmonella Enterocolitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the investigators study is to evaluate if short-course of ceftriaxone therapy could shorten the clinical courses of severe nontyphoidal Salmonella enterocolitis in children and the excretion of Salmonella in feces. |
MING_HAN TSAI; | 2010-08-01 |
| 392 | Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache (PDPH) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: PDPH is a common problem after either intentional or unintentional Dural puncture. It is especially common in young female patients and in patients undergoing Lumbar Puncture using the typical kit containing large 20 gauge needles (1). Hypothesis is that Cosyntropin therapy is at least as effective as current conservative therapy (caffeine/fluid) and/or Epidural Blood Patch. Patients will be randomly assigned to undergo either: (1) EBP with IVF therapy or (2)Cosyntropin IV with IVF therapy. Endpoints will be a pain score that is given prior to the procedure, Emergency Department (ED) discharge pain score and post procedural day (PPD) day 1, … |
STEVEN HANLING; | 2010-08-01 |
| 393 | Prevention of Febrile Neutropenia in Pediatric Cancer Patients By Lactobacillus Rhamnosus GG and Bifidobacterium Animalis Subspecies. Lactis BB-12 in Combination With Inulin and Oligofructose PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Febrile neutropenia (FN) is a major life-threatening treatment complication in cancer patients undergoing intensive chemotherapy. Endogenous flora is considered to be one of the main sources of infections during neutropenia. Competitive inhibition of gut mucosal colonization by pathogenic microorganisms using synbiotics could represent one of the potential options for its prevention. Synbiotics represent combination of two components: probiotics and prebiotics. Probiotics are live microorganisms, … |
VLADIMIR HOLEC; | 2010-07-01 |
| 394 | Effectiveness and Efficacy of Zinc With Probiotics for The Treatment of Acute Diarrhea in Young Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diarrheal disease is one of the major causes of morbidity and mortality in children under five. Disease is treated symptomatically with oral rehydration (ORS) as a basic measure. In children with severe zinc deficiency, diarrhea is common and responds quickly to zinc supplementation. Zinc supplementation may also helpful in diarrheal children without zinc deficiency. Effectiveness of zinc was proven in developing countries but was not in Europe. Objective of our study is to assess whether zinc supplementation given with probiotics and ORS is effective in acute diarrhea in children in Poland. |
LESZEK SZENBORN; | 2010-07-01 |
| 395 | A Pivotal Clinical Trial Examining The Safety and Effectiveness of The Adherus Dural Sealant System When Used As A Dural Sealant in Cranial Procedures PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to demonstrate the safety and effectiveness of the Adherus Dural Sealant System when used as a dural sealant in conjunction with standard methods of dural repair in cranial procedures. |
MARK SMITH; | 2010-06-01 |
| 396 | The Impact of Vaccination With A Serogroup A Meningococcal Conjugate Vaccine on Carriage of Serogroup A Meningococci in Mali and Niger PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Meningococcal disease occurs throughout the world but attack rates in the Sahelian and sub-Sahelian regions of Africa – the African meningitis belt – are many times higher than those seen in any other part of the world. During 2009, over 70,000 meningitis cases and 3,200 deaths were reported in Nigeria, Niger, and Chad alone. In 2001, a public private partnership between WHO and PATH was created, the Meningitis Vaccine Project (MVP). The MVP set out to develop an affordable meningococcal serogroup A conjugate vaccine (MenAfriVac™) for use in the African meningitis belt. This was successfully achieved, and the new vaccine, … |
BRIAN GREENWOOD; | 2010-05-01 |
| 397 | Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis. |
SANG-HO CHOI; | 2010-05-01 |
| 398 | Clinical Features, Microbiological Characteristics, and Differential Diagnosis of Postneurosurgical Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis. |
SANG-HO CHOI; | 2010-05-01 |
| 399 | A Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cryptococcal meningitis (CM) is an infection of the membranes covering the brain and spinal cord, caused by the fungus Cryptococcus neoformans. CM most often affects people with compromised immune systems, like those with advanced HIV infection. This study explored the safety, tolerability, and therapeutic effect of a new treatment regimen with high-dose fluconazole for management of CM in HIV-infected patients. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2010-04-16 |
| 400 | Surveillance of Hospitalised Pneumonia and Bacterial Meningitis in Tône District, Togo, 2010-2013 PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to estimate the burden of disease due to pneumococci, other bacteria and viruses in the African meningitis belt prior to pneumococcal conjugate vaccine introduction and to estimate the population impact of the vaccine after its implementation in 2014. In a defined population of a sanitary district in northern Togo, during the period 2010 to 2017, investigators enroll patients of all ages with suspected pneumonia requiring hospitalization or suspected bacterial meningitis. Patients are evaluated by bacteriology and molecular biology techniques on blood, cerebro-spinal fluid, nasal aspirates and by chest X-ray. |
JENNIFER C MOÏSI; | 2010-04-01 |
| 401 | An Open Randomised Trial of Ceftriaxone V Penicillin and Gentamicin in Infant Severe Sepsis and Bacterial Meningitis in Malawi PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to improve the outcome of infants (<2 months) with severe sepsis and meningitis at the Queen Elizabeth Central Hospital, Blantyre, Malawi. Currently WHO recommends the treatment of infant severe sepsis and bacterial meningitis with 14 to 21 day course of penicillin and gentamicin as first line. The second line treatment is cefotaxime or ceftriaxone. Severe bacterial infections are common in infants under 2 months of age and the mortality is very high (~50%). There are several reasons for this; ... |
ELIZABETH MOLYNEUX; | 2010-04-01 |
| 402 | A Natural History Study of Tuberculosis in China; Correlates of A Successful Response to Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: – In spite of well-researched treatments and therapies, 5 to 10 percent of tuberculosis (TB) patients who have initially successful TB treatments will relapse, usually within a year after completion of therapy. This percentage is even greater for patients who are infected with multi-drug resistant and extensively drug resistant types of TB. Because the People s Republic of China has the second highest number of TB cases in the world, researchers are interested in studying TB patients in China to evaluate their response to treatment on a long-term basis. Objectives: – … |
CLIFTON E BARRY; | 2010-02-02 |
| 403 | FDG-PET/CT: A Tool in Diagnosis and Treatment Response Monitoring of Extrapulmonary Tuberculosis in HIV Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective Prospectively describe the kinetics of 18F-FDG uptake of extrapulmonary TB after two months and at the end of TB treatment in HIV patients. Evaluate 18F-FDG-PET/CT as a TB treatment response monitoring tool. Design The investigators performed baseline FDG-PET/CT, another FDG-PET/CT after 2 months of TB treatment and a PET/CT at the end of treatment in 18 HIV/TB patients. The investigators correlated evolution of FDG uptake with clinical evolution of patients. |
CHARLOTTE MARTIN; | 2010-02-01 |
| 404 | Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to perform a pilot study to assess the potential use of Bevacizumab (a vascular endothelial growth factor (VEGF) inhibitor) in sepsis. |
NATHAN SHAPIRO; | 2010-02-01 |
| 405 | Impact of PCV on Disease and Colonization Among Native American Communities PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the impact of pneumococcal conjugate vaccine on carriage of pneumococcus in the nasopharynx and on the incidence of invasive pneumococcal disease in the community. |
KATHERINE O’BRIEN; | 2010-01-01 |
| 406 | Intrathecal Therapy for Adult Tuberculous Meningitis: Impact on Clinical Outcomes PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculous meningitis (TBM) is the most lethal form of tuberculosis (TB). While anti-TB regimens remain the cornerstone of treatment, spinal injection of dexamethasone is considered a potentially effective adjuvant therapy. However, its impact on mortality and disability remains uncertain. This study analysed all TBM patients admitted to Beijing Chest Hospital affiliated with Capital Medical University from January 1, 2010 to December 31, … |
NIE WENJUAN; | 2010-01-01 |
| 407 | Clinical Study to Evaluate The Efficacy, Pharmacokinetics and Safety of Immunoglobulin Intravenous (Human) 10% (NewGam) in Patients With Primary Immunodeficiency Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to determine the efficacy of NewGam in preventing serious bacterial infections and to determine the pharmacokinetic profile of NewGam. The safety of NewGam and its effect on quality of life were also evaluated. |
OCTAPHARMA | 2010-01-01 |
| 408 | The Impact of A Breastfeeding Support Intervention on Breastfeeding Duration in Jaundiced Infants Admitted to A Tertiary Care Centre: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Breastfeeding decreases the risk of many infantile infectious diseases and certain types of cancers in women. It strengthens the bond between mothers and babies and decreases the health care cost to society by making children healthier. Although it is controversial, breastfeeding has been reported to increase the risk of jaundice in the neonatal period. There is some evidence that mothers of hospitalized jaundiced infants discontinue breastfeeding early, … |
CATHERINE POUND; | 2009-10-01 |
| 409 | OUTCOMES IN CHILDREN WITH DEVELOPMENTAL DELAY AND DEAFNESS: A PROSPECTIVE, RANDOMIZED TRIAL PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Children with special needs require complex, individualized therapy to maximize their long-term quality of life. One subset of children with special needs includes those with both developmental delays and deafness. Currently, there is little compelling evidence supporting the idea that cochlear implantation provides benefit to children that don’t have the cognitive potential to develop normal speech and language. We will perform a prospective, randomized clinical trial to answer the question of which intervention provides more benefit to this population of children using validated, … |
JOHN S. OGHALAI; | 2009-09-01 |
| 410 | A Randomized Clinical Trial of Immediate Versus Standard Antiretroviral Therapy for HIV-infected Adults Presenting With Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to compare early versus standard timing of initiation of antiretroviral therapy (ART) with respect to clearance of Cryptococcus neoformans from cerebrospinal fluid (CSF) among HIV-infected adults with Cryptococcal Meningitis. The investigators hypothesize that early ART mediates more rapid clearance of C. neoformans from CSF, as manifested by a greater rate of decrease in C. neoformans colony forming units (CFUs) during the first 28 days after initiating antifungal treatment. Secondary hypotheses are that recovery of pathogen specific cellular immunity directed at C. neoformans, … |
GREGORY BISSON; | 2009-09-01 |
| 411 | A Phase II, Open Label, Randomised, Single Centre Study To Evaluate The Importance Of Naturally Induced Immune Regulation On The Mucosal Immune Response To Meningococcal Serogroup B Outer Membrane Vesicle (Omv) Vaccine When Administered Intramuscularly To Adults & Adolescents Related Papers Related Patents Related Grants Related Experts View Highlight: Meningitis or septicaemia (blood poisoning) caused by group B meningococcal infection (MenB) is an important cause of death and disability in the UK. Prevention through vaccination therefore remains a key public health priority. Research from national meningitis vaccine programmes against MenC, Hib and Streptococcus pneumoniae show us that their success is in part due to their ability to protect both the vaccinated and the unvaccinated, … |
UNIVERSITY HOSPITALS BRISTOL AND WESTON NHS FOUNDATION TRUST | 2009-09-01 |
| 412 | Baby-Friendly Community Health Services Evaluation: A Cluster Randomised Controlled Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The Norwegian Action Plan on Nutrition aim at increasing the prevalence of breastfeeding. The initiative Baby-Friendly Community Health Services (BFCHS) is an initiative to reach this goal. BFCHS is developed from the concept The Baby-Friendly Hospital Initiative by WHO/UNICEF, and the intention is to increase the quality of breastfeeding counseling at Norwegian well-baby clinics. The purpose of the study The study seeks to answer the following research questions: – What effect does the process of being certified as a BFCHS have on the proportion of mothers who exclusively breastfeed their children for 5 months? – … |
ANNE BERUG; | 2009-08-01 |
| 413 | A Single Arm Pilot Study of Intrathecally Administered DepoCyt® With Systemic Sorafenib in The Treatment of Neoplastic Meningitis From Solid Tumors Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the tolerability and side effects of oral sorafenib in combination with intrathecal DepoCyt. |
EDWARD PAN; | 2009-08-01 |
| 414 | Single Centre Open-Label Randomised Trial of Meningococcal Serogroup ACYW-135 B Cell Response to Primary & Booster Doses of ACWY Conjugate Vaccine & Primary Dose of ACWY Polysaccharide With Booster Dose of ACWY Conjugate in Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate and compare the immune response to two vaccines against 4 related bacteria: meningococcal serogroups A, C, W-135 and Y. These bacteria can cause meningitis and /or septicaemia (blood poisoning). The two vaccines are a protein-polysaccharide conjugate vaccine (MenACWY)and a meningococcal plain polysaccharide vaccine(MenACWY PS). Both vaccines are licensed and are currently used for travellers to areas with a high incidence of invasive meningococcal disease. However, plain polysaccharide vaccines are known to be poorly immunogenic in children and they do not stimulate immunological memory, apart from the serogroup A component. In contrast, … |
ANDREW POLLARD; | 2009-06-01 |
| 415 | Discontinuation of Primary and Secondary Prophylaxis for Opportunistic Infections in HIV-infected Patients Who Had CD4+ Cell Count <200 Cells/mm3 But Undetectable Plasma HIV-1 RNA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the incidence of opportunistic infections between HIV-infected patients who continue and discontinue primary or secondary prophylaxis for opportunistic infections in whom receiving combination antiretroviral therapy and achieve undetectable HIV-1 RNA, but CD4 cell counts are less than 200 cells/mm3. |
ROMANEE CHAIWARITH; | 2009-06-01 |
| 416 | Needle-Free Jet Injection of Lidocaine for Local Anesthesia During Lumbar Puncture: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The J-Tip Device allows an intradermal needle-free jet injection of 1% buffered lidocaine. This study compares needle-free jet injection of lidocaine to saline in reducing pain prior to lumbar puncture in infants. Methods: Randomized, double-blinded, placebo controlled trial involving infants, less than 3 months of age, presenting to the emergency department meeting clinical criteria for a lumbar puncture. All patients were administered the J-tip and randomized to either treatment with 1% lidocaine or an equivalent amount of sterile normal saline prior to lumbar puncture. |
BLAKE BULLOCH; | 2009-06-01 |
| 417 | A Pilot Study of Systemically Administered Bevacizumab in Patients With Neoplastic Meningitis (NM) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical research study is to learn if and how Avastin (bevacizumab) may affect cancer that has spread to the meninges of the brain or the spinal cord. The safety of this drug will also be studied. Objectives: 1. Primary: 1. Determine preliminary response data of intravenous bevacizumab in patients with NM a. As measured by clearance of malignant cells from the Cerebrospinal fluid (CSF) at 2, 4, 6, 12, 18, and 24 weeks, then every 8 weeks up to 54 weeks, … |
IVO D. TREMONT; | 2009-06-01 |
| 418 | Effectiveness Assessment of Vaccinating Schoolchildren Against Influenza The in São Paulo, 2009 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Vaccinating schoolchildren against influenza would prevent the disease among non-vaccinated household members. |
EXPEDITO J LUNA; | 2009-05-01 |
| 419 | Impact of The 7 Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. Pneumoniae in Healthy Jordanian Infants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Nasopharyngeal (NP) colonization of S. pneumoniae in infants is generally acquired at approximately 4-6 months of age. Although there are differences in the prevalence and rank order of serotypes obtained from NP specimens and from those with invasive diseases, … |
ADNAN AL-LAHHAM; | 2009-05-01 |
| 420 | A Randomized Double Blind Placebo Controlled Trial to Assess The Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Japanese encephalitis is caused by a viral infection of the brain transmitted by the bite of an infected mosquito. Patients with Japanese encephalitis can rapidly develop worsening conscious level and seizures. Around a third will die from the infection and half of survivors have serious long-term neurological disability. The majority of those affected are children. There are many causes of viral encephalitis, however Japanese encephalitis virus is the most common cause worldwide with over 60,000 cases annually. It occurs over much of Asia and the geographical range is expanding. There is no specific treatment for Japanese encephalitis virus, … |
AJIT RAYAMAJHI; | 2009-05-01 |
| 421 | Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test a drug called MGAWN1 for the treatment of West Nile infections. |
MACROGENICS | 2009-05-01 |
| 422 | A Phase 1 Randomized, Open-label, Parallel-group, Active- And Placebo-controlled Study To Assess Safety And Tolerability Of 60, 120, And 200 Mcg Meningococcal Group B Rlp2086 Vaccine In Healthy Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and tolerability of an investigational meningococcal B rLP2086 vaccine in healthy adults. |
PFIZER | 2009-04-01 |
| 423 | A Comparison Between A New Experimental Enzymatic Assay to Real Time PCR for The Diagnosing of Central Nervous System Enteroviral Infection Related Papers Related Patents Related Grants Related Experts View Highlight: A new enzymatic assay was developed by NMD Diagnostics for rapid diagnosis of Enteroviral CNS infection. This study will compare this assay to RT-PCR, by testing human CSF samples taken from children at the ER who are undergoing a spinal tap due to suspicion of meningitis. |
YECHIEL SCHLESINGER; | 2009-04-01 |
| 424 | Efficacy of GSK Biologicals’ Candidate Malaria Vaccine (257049) Against Malaria Disease Caused By P. Falciparum Infection in Infants and Children in Africa PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this observer-blind study is to gather key efficacy, safety, and immunogenicity information on GSK’s candidate malaria vaccine in infants and children. |
GLAXOSMITHKLINE | 2009-03-27 |
| 425 | Safety and Efficacy of Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim is to establish the non-inferiority of several simplified, home-based antibiotic regimens compared to the standard course of parenteral antibiotics for the empiric treatment of suspected sepsis in Bangladeshi young infants whose parents refuse hospitalization. Three alternative regimens will be compared with a standard (reference) regimen of injectable procaine-benzyl penicillin and gentamicin once daily each for seven days. Alternative regimens are (1) injectable gentamicin once daily and oral amoxicillin twice daily for seven days; (2) injectable penicillin and gentamicin once daily for two days followed by oral amoxicillin twice daily for five days; … |
ABDULLAH BAQUI; | 2009-03-01 |
| 426 | Mild Induced Hypothermia to Treat Severe Community Acquired Meningitis in Adults Admitted to Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacterial meningitis is a severe infection of the envelope which surrounds the brain. It is sometimes responsible for a cerebral oedema mattering with a loss of consciousness (coma). The usual treatment of this affection is based on the antibiotic therapy, … |
MOURVILLIER BRUNO; | 2009-03-01 |
| 427 | A Randomized, Single-blind, Placebo-controlled, Phase 2 Trial Of The Safety, Immunogenicity, And Tolerability Of Meningococcal Serogroup B (Mnb) Rlp2086 Vaccine At Doses Of 60 Mug, 120 Mug, And 200 Mug In Healthy Adolescents Aged 11 To 18 Years PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and immunogenicity of an investigational meningococcal B rLP2086 vaccine in adolescents aged 11 to 18 years old. |
PFIZER | 2009-02-01 |
| 428 | Comparison of The Immunogenicity of The 3+1 Schedule and The 2+1 Schedule of 7-valent Pneumococcal Conjugated Vaccine in Young Chinese Infants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumonia is one of the most prevalent diseases in infants and children. The incidence of pneumonia in children less than 5 years old is about 34-40 cases per 1000 in Europe and America and more than 2 million children die of pneumonia annually. It was reported that Streptococcus pneumoniae accounted for 13%-53% of lower respiratory tract infections in different age group of infants or children. In addition, 7%-9% of bacterial meningitis was due to Streptococcus pneumoniae infection. In addition, children infected with Streptococcus pneumoniae often transmit the pathogens to adult. As a result, … |
LAU YU LUNG; | 2009-02-01 |
| 429 | An Open Label, Randomized, Phase 1/2 Trial Of The Safety, Tolerability, And Immunogenicity Of Meningococcal Group B Rlp2086 Vaccine In Healthy Infants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to evaluate the safety and immunogenicity of an investigational meningococcal B vaccine in healthy infants. |
PFIZER | 2009-01-01 |
| 430 | Study of Safety, Immunogenicity and Immunological Memory of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether 7-valent pneumococcal conjugate vaccine safely induces immune responses and immunological memory in children with idiopathic nephrotic syndrome in remission. |
CHRISTINA LIAKOU; | 2009-01-01 |
| 431 | A Phase I Open-Label, Dose-Finding Study to Evaluate The Safety and Efficacy of Concurrent Radiosurgery and Erlotinib Administration in Non-Small Cell Lung Cancer Patients With Brain Metastases Related Papers Related Patents Related Grants Related Experts View Highlight: RATIONALE: Erlotinib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. Radiation therapy uses high-energy x-rays to kill tumor cells. Stereotactic radiosurgery may be able to deliver x-rays directly to the tumor and cause less damage to normal tissue. Erlotinib may make tumor cells more sensitive to radiation therapy. Giving erlotinib together with stereotactic radiosurgery may kill more tumor cells. PURPOSE: This phase I clinical trial is studying the side effects of erlotinib when given together with stereotactic radiosurgery and to see how well it works in treating patients with non-small cell lung cancer with brain metastases. |
JAMES L. RUBENSTEIN; | 2009-01-01 |
| 432 | Efficacy, Tolerability and Pharmacokinetic Comparison of Immune Globulin Intravenous (Human), 10% (GAMMAGARD LIQUID/KIOVIG) Administered Intravenously or Subcutaneously Following Administration of Recombinant Human Hyaluronidase (rHuPH20) in Subjects With Primary Immunodeficiency Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to develop a subcutaneous treatment option for participants with Primary Immunodeficiency Diseases (PID) that allows an administration of Immune Globulin Intravenous (Human), 10% at the same frequency as IV administration. |
BAXALTA NOW PART OF SHIRE | 2008-12-18 |
| 433 | An Open-Label Safety And Blood Collection Study In Mnb Rlp2086 Vaccinated Healthy Adult Volunteers For Immunological Assay Development PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety of an investigational meningococcal B rLP2086 vaccine in adults and to obtain blood samples from immunized subjects for use in assay development. |
WYETH IS NOW A WHOLLY OWNED SUBSIDIARY OF PFIZER | 2008-10-01 |
| 434 | Duration of Hypothermia for Neuroprotection After Pediatric Cardiac Arrest PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, children who survive cardiac arrest will be evaluated whether 24 or 72 hours of whole body hypothermia (cooling) during recovery is better to help prevent brain injury and improve outcome. The investigators will also test the safety of cooling patients for 24 and 72 hours. The investigators hypothesize that 72 hours of cooling will be more beneficial than 24 hours without compromising safety. |
ERICKA FINK; | 2008-10-01 |
| 435 | Community Acquired Bacteremic Syndromes in Young Nigerian Children PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: To define the etiologic agents of community acquired bacteremic syndromes (defined as septicemia, bacteremia, pneumonia and/or meningitis) in a malaria endemic setting. |
STEPHEN OBARO; | 2008-09-01 |
| 436 | Post-Licensure Safety Surveillance Study of Routine Use of PENTACEL® Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus B Conjugate (Tetanus Toxoid Conjugate) Vaccine PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective for this study is to characterize the safety profile of PENTACEL® vaccine for identification of potential vaccine-related adverse events not currently associated with PENTACEL® vaccine administration. |
SANOFI PASTEUR A SANOFI COMPANY | 2008-09-01 |
| 437 | A Phase II, Randomized Controlled Trial of Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Growth Hormone (GH) deficiency, defined by insufficient GH response to a variety of stimulating compounds, is found in 20-35% of adults who suffer traumatic brain injuries (TBI) requiring inpatient rehabilitation1. However, there is no accepted gold standard for diagnosing GH deficiency in this population. Further, the major effector molecule of the somatotropic axis, Insulin-Like Growth Factor-1 (IGF-1) has recently been recognized as an important neurotrophic agent. Since most repair and regeneration after TBI occurs within the first few months after injury, … |
RAMON DIAZ-ARRASTIA; | 2008-09-01 |
| 438 | Evaluation of Meropenem Penetration Across Blood-Brain Barrier in Patients With Central Nervous System Infection After Neurosurgery and Optimization of Meropenem Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, open-label study investigated the pharmacokinetic profile of meropenem in patients with post-neurosurgical central nervous system (CNS) infection, especially its BBB penetration into cerebrospinal fluid (CSF). |
JUFANG WU; | 2008-09-01 |
| 439 | Procalcitonin Level As A Prognostic Marker and Its’ Kinetics in Children With Bacterial Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purposes of this study are: 1. To determine whether procalcitonin level at admission of pediatric patients with bacterial infections can be used as a marker for prediction of defervescence and hospitalization length 2. To examine the kinetics of procalcitonin in pediatric patients with bacterial infections and persistent fever |
YECHIEL SCHLESINGER; | 2008-08-01 |
| 440 | Improved Diagnosis of Peritoneal Dialysis Peritonitis By Calorimetry Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to analyze whether calorimetry compared to conventional methods (i.e.blood culture systems)is superior to diagnose peritoneal dialysis related peritonitis. |
MICHAEL MAYR; | 2008-08-01 |
| 441 | A Multi-centric Study on Treatment of Abdominal Tuberculosis (Intestinal or Peritoneal): A Randomized Controlled Trial to Compare The 6 Months of Cat I Treatment With 9 Months of Cat I Treatment (Extension for 3 Months) in Abdominal Tuberculosis Under The Revised National Tuberculosis Control Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Most of the guidelines on the treatment of tuberculosis suggest that 6 months treatment is sufficient for extrapulmonary tuberculosis except for bone tuberculosis and tubercular meningitis. Despite these recommendations, most physicians treating abdominal tuberculosis use antituberculous therapy for 9 months, sometimes even 12 months without any scientific justification. In a randomized controlled trial, Balasubramaniam et al reported no difference in success rate of 6mo (99%) vs 12 months (94%) antituberculous drugs (conventional strategy) in the treatment of abdominal tuberculosis. Although Directly Observed Therapy (DOTs) have been proved to be effective in patients with pulmonary tuberculosis, lymph nodal tuberculosis, however, … |
GOVIND K MAKHARIA; | 2008-07-01 |
| 442 | Pharmacokinetics and Pharmacodynamics of Intravenous Colistin- Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: More than 80 patients at the University of Pittsburgh Medical Center have been infected with Pseudomonas aeruginosa, lacking susceptibility to all commercially available antibiotics except colistin. This antibiotic was developed in the 1960s and preliminary pharmacokinetic studies were performed at that time. Dosing recommendations, on the basis of these pharmacokinetic studies, are listed in the drug’s product information. However, there are no dosing recommendations for patients requiring renal replacement therapy (either intermittent hemodialysis or continuous venovenous hemofiltration). Furthermore, … |
FERNANDA SILVEIRA; | 2008-06-01 |
| 443 | A Multicenter Extension Study of The Efficacy, Tolerability, and Safety of Immune Globulin Subcutaneous (Human) IgPro20 in Subjects With Primary Immunodeficiency (PID) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether a long-term use of a new human immunoglobulin G with proline (IgPro) is safe and effective in the treatment of primary immunodeficiency. |
CSL BEHRING | 2008-06-01 |
| 444 | Evaluation of The Efficacy and Safety of Flebogamma 5% DIF [Immune Globulin Intravenous (Human)] for Replacement Therapy in Pediatric Subjects With Primary Immunodeficiency Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, open-label study to assess the efficacy and safety of Flebogamma 5% DIF in the pediatric population. |
MARK BALLOW; | 2008-05-01 |
| 445 | Interest of The Dosage of CA 15-3 in CSF for Diagnosing Carcinomatous Meningitis in Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: RATIONALE: Studying samples of cerebrospinal fluid from patients with cancer or meningeal syndrome may help doctors identify biomarkers related to cancer. PURPOSE: This clinical trial is studying cerebrospinal fluid samples in diagnosing carcinomatous meningitis in patients with cancer or meningeal syndrome. |
EMILIE LE RHUN; | 2008-04-01 |
| 446 | Benefits and Risks of Early Antiretroviral Therapy in HIV-infected Adults in Abidjan, Côte D’Ivoire: Randomized Controlled Trial (ANRS 12136 TEMPRANO) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The Temprano trial is based on the following assumptions: – ART initiation at CD4 counts <800/mm3 could significantly reduce the probability of severe HIV-related morbidity or death in the medium term. - Tuberculosis and tuberculosis-related deaths are likely to represent a considerable proportion of morbidity and mortality among HIV-infected patients with high CD4 counts in sub-Saharan Africa. Therefore, 6-month Isoniazide Prophylaxis for Tuberculosis (IPT) and early ART could enhance each others efficacy. |
XAVIER ANGLARET; | 2008-03-01 |
| 447 | Oral Glycerol and High-Dose Rectal Paracetamol to Improve The Prognosis of Childhood Bacterial Meningitis – A Prospective, Randomized, and Double-Blind Clinical Study Using A Two-by-Two Factorial Design PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacterial meningitis remains a significant cause of morbidity and mortality in children, especially in countries with limited resources. Efforts to improve the grim outcome have included altering the first line antibiotic therapy, … |
ELIZABETH MOLYNEUX; | 2008-03-01 |
| 448 | Open-label, Randomized, 3-arm, Phase 3B Clinical Study to Investigate The Safety and Immunogenicity of A Concomitant Administration of Group C Meningococcal Polysaccharide-Tetanus Toxoid Conjugate (MenC-TT) Vaccine and 7-valent Pneumococcal CRM197-conjugate Vaccine (PCV7) in Toddlers Previously Immunized During Infancy With PCV7 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study in healthy toddlers who have not previously been immunized against MenC infection and who completed their primary immunization series with PCV-7 (3 vaccinations) during infancy is to demonstrate that the concomitant administration of a single dose of MenC-TT vaccine and a PCV7 booster does not influence the immune response to the seven pneumococcal strains contained in PCV7 as compared to administration of PCV7 alone, and does not influence the immune response to the MenC-TT vaccine as compared to administration of MenC-TT vaccine alone. |
PFIZER | 2008-03-01 |
| 449 | Cerebrospinal Fluid (CSF) Drainage and Cytokine Profiling in The Treatment of Acute Spinal Cord Injury (SCI) – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall purpose of this pilot study is to evaluate CSF drainage as a potential neuroprotective strategy after acute spinal cord injury (SCI). |
BRIAN KWON; | 2008-03-01 |
| 450 | A Randomized Study of Optimal Pain Management: Standard Pain Control Versus Early Intervention With Intrathecal Therapy in Patients With Advanced Pancreatic Cancer Related Papers Related Patents Related Grants Related Experts View Highlight: RATIONALE: Giving medications in different ways may change their effectiveness in controlling pain. It is not yet known whether intrathecal therapy is more effective than standard therapy in controlling pain in patients with pancreatic cancer. PURPOSE: This randomized clinical trial is studying standard pain control to see how well it works compared with intrathecal therapy in controlling pain in patients with locally advanced, unresectable, or metastatic pancreatic cancer. |
MICHAEL ERDEK; | 2008-03-01 |
| 451 | Contamination of Bacillus Species Sepsis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacillus species are ubiquitous gram-positive spore-forming organisms. They rarely cause disease in the immunocompetent and are more frequently isolated as a culture contaminant. However, Bacillus Species can cause severe systemic infections in immunocompromised patients including preterm infants. The purpose of this study is to identify the risk factors of these infections. |
MOHAMED AMINE YANGUI; | 2008-01-01 |
| 452 | Iowa/Nucleus 10/10 Mm and Nucleus Freedom Cochlear Implants Implanted Bilaterally in Children Ages 12-24 Months Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate whether the Iowa/Nucleus 10/10 mm in one ear, in conjunction with a Nucleus Freedom implant in the other ear can provide useful binaural hearing in pediatric subjects who have bilateral severe to profound hearing loss and meet the criteria for cochlear implantation. The Iowa/Nucleus 10/10 mm cochlear implant has a short, 10 mm electrode array that it is inserted only into the more basal region of the cochlea. Unlike a conventional cochlear implant, … |
BRUCE J GANTZ; | 2007-12-01 |
| 453 | Efficacy of A New Hypotonic Oral Rehydration Solution Containing Zinc and Prebiotics in The Treatment of Children With Acute Diarrhea PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypotonic oral rehydration solutions (ORS) containing zinc and/or prebiotics have been proposed for the treatment of pediatric acute diarrhea but conclusive clinical data about their effect are scanty, especially for children living in developed countries. The investigators aim to evaluate the efficacy of a new hypotonic ORS containing zinc and prebiotics in children with acute diarrhea. |
ROBERTO BERNI CANANI; | 2007-11-01 |
| 454 | Hyperphenylalaninemia in Cerebral Malaria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to see if children, who develop coma from malaria, are not making enough of a vitamin-like chemical, tetrahydrobiopterin (BH4), which is required for the brain to function normally. This information may help to identify new ways to treat malaria in the future. Study participants will include 512 children, ages 6 months to 6 years. Participants will be placed into one of 4 groups: well children; children with mild malaria; children without malaria, … |
DONALD L GRANGER; | 2007-10-01 |
| 455 | Evaluation of The Response to A Single Dose of Menactra® in Children Aged 5 to 8 Years Who Had Previously Received Two Doses of Quadrivalent (A, C, Y, W-135) Meningococcal Polysaccharide Vaccine Before Age 2 Years in Saudi Arabia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted among children in Saudi Arabia who previously received two doses of A, C, Y, W-135 polysaccharide vaccine before the age of 2 years, and in meningococcal vaccine-naïve children (Control Group). This study will evaluate the administration of Menactra® in terms of the serum bactericidal antibody it induces in the two study groups. Safety of Menactra® vaccine will be described. |
SANOFI PASTEUR A SANOFI COMPANY | 2007-09-01 |
| 456 | Open Label, Phase III Safety, Efficacy, and Pharmacokinetic Study of NABI-IGIV 10% [Immune Globulin Intravenous (Human), 10%] in Subjects With Primary Immune Deficiency Disorders (PIDD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if NABI-IGIV (10%) [Immune Globulin Intravenous (Human), 10%] is safe and effective in preventing serious bacterial infections (SBIs) in the treatment of patients with primary immune deficiency disorders (PIDD) when compared to historical control data. |
ADMA BIOLOGICS | 2007-09-01 |
| 457 | Characteristics of Cord Blood Immunologic Parameters of Infants < 32 Weeks Gestation Related Papers Related Patents Related Grants Related Experts View Highlight: Infants in the NICU are at high risk for morbidity and mortality from infections of any onset. Diagnosis of these infections is imperfect at best. Patterns of inflammatory and regulatory proteins (cytokines & chemokines, in addition to antigen detection on antibody secreting cells (ASC’s)may provide a more accurate and rapid approach to diagnosis of infections in these high-risk patients. |
JAMES R MURPHY; | 2007-08-01 |
| 458 | COMPAS: A Phase III Study to Demonstrate Efficacy of GSK Biologicals’ 10-valent Pneumococcal Vaccine (GSK1024850A) Against Community Acquired Pneumonia and Acute Otitis Media PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study in a large number of healthy children less than 3 years old to measure the efficacy of GlaxoSmithKline (GSK) Biologicals’ 10-valent pneumococcal conjugate candidate vaccine (Synflorix vaccine, or GSK1024850A) to prevent cases of pneumonia (lung infection) likely caused by bacteria (Streptococcus pneumoniae and Haemophilus influenzae) or cases of otitis media (ear infection) in children under 3 years old. |
GLAXOSMITHKLINE | 2007-06-28 |
| 459 | Phase I/II Study of Safety and Immunogenicity of Quadrivalent Meningococcal Conjugate Vaccine (MCV4) in HIV-Infected Children and Youth And Open Label Immunogenicity Study of A Booster Dose of MCV4 in Previously Immunized HIV-Infected Children and Youth PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacterial meningitis infection is common in youth 2 to 24 years of age in the United States. This disease can be treated by antibiotics, but mortality rates associated with meningitis of up to 53% have been estimated. Vaccination against meningitis may be effective in preventing this disease, especially for HIV-infected youth who have weakened immune systems. The purpose of this study was to determine the safety of and immune response to a preventive meningitis vaccine in HIV-infected youth. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2007-06-01 |
| 460 | A Randomised, Multi-centre, Open-label, Phase III Study of Adjuvant Lapatinib, Trastuzumab, Their Sequence and Their Combination in Patients With HER2/ErbB2 Positive Primary Breast Cancer PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a four-arm (parallel group) randomized, open-label, multicenter Phase 3 study to investigate the use of a combination of Lapatinib and Trastuzumab, a sequence of Trastuzumab followed by Lapatinib, and Lapatinib alone, compared to Trastuzumab alone in the adjuvant treatment of Human Epidermal Growth Factor Receptor 2 (HER2) positive early breast cancer. |
NOVARTIS PHARMACEUTICALS | 2007-05-16 |
| 461 | Pneumococcal Vaccine Response in COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumococcal disease is a serious bacterial infection that can affect different parts of the body, including the lungs. People with chronic illnesses, such as chronic obstructive pulmonary disease (COPD), have a greater risk of developing pneumonia and meningitis as a result of pneumococcal disease. This study will compare the immune response to two types of pneumococcal vaccines in adults with COPD. |
UNIVERSITY OF MINNESOTA | 2007-03-01 |
| 462 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy and Safety of Mycograb® As Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, placebo-controlled, parallel-group, multicenter efficacy and safety trial to evaluate Mycograb®. Subjects will be randomized to receive either Mycograb® (dosed 1 mg/kg) or placebo during the first week of induction therapy (amphotericin B plus 5-flucytosine) via a central line or peripheral venous line twice daily for 7 consecutive days. The total duration of the study will be approximately 24 months. |
NOVARTIS PHARMACEUTICALS | 2007-03-01 |
| 463 | A Randomized, Prospective Double Blind Placebo Control Clinical Trial of Prednisone As Adjunctive Therapy for The Treatment of Hospitalized Patients With Pulmonary TB and HIV Co-infection Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if 30-day survival will be improved with addition of prednisone to standard tuberculosis (TB) therapy. |
OTTAWA HOSPITAL RESEARCH INSTITUTE | 2007-02-01 |
| 464 | Safety, Efficacy, and Pharmacokinetics of Amphotericin B Lipid Complex at 10 Mg/kg/d for 7 Days or 5.0 Mg/kg/d for 14 Days As Induction Therapy for Disseminated Cryptococcosis in Patients With HIV Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if initial therapy with ABLC at 10/mg/kg/d for 7 days are at least effective as ABLC at 5.0 mg/kg/d X 14 days as induction treatment of patients with disseminated cryptococcosis and HIV. |
SHMUEL SHOHAM; | 2007-01-01 |
| 465 | Evaluation of Streptococcus Pneumoniae Nasopharyngeal Carriage Rate in Children Receiving Pneumococcal Conjugated Vaccine (Prevnar®) Under The Auspices of The Taipei City Government Vaccination Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Objective: To evaluate the impact of PCV7 vaccination on NP carriage rate of vaccine serotypes and serotype distribution Secondary Objective: To evaluate the impact of PCV7 vaccination on NP carriage of antibiotic resistant pneumococci and serotype distribution. |
TRIAL MANAGER; | 2006-11-01 |
| 466 | A Phase I Study Evaluating The Safety and Immunogenicity of A New TB Vaccine, MVA85A, in Healthy Volunteers Who Are Infected With HIV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to evaluate the safety of MVA85A in healthy volunteers in the UK who are infected with HIV. In phase I studies, a single vaccination with MVA85A, when administered at a dose of 5 x 10^7pfu intradermally, has been shown to be safe in both mycobacterially naïve individuals, those previously vaccinated with BCG and latently infected individuals. Additionally, 5 x 10^7 pfu MVA containing HIV antigens administered twice, 4 weeks apart, in HIV positive individuals, … |
HELEN MCSHANE; | 2006-11-01 |
| 467 | Infections Caused By Enterobacteriaceae Producing Extended-Spectrum Β-Lactamases in Italy: Molecular Epidemiology, Clinical Impact, Treatment Outcome and Risk Factors PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the molecular epidemiology, clinical impact, treatment outcome and risk factors for infections caused by Enterobacteriaceae producing ESBLs in Italy in a large multicenter observational survey. SPECIFIC OBJECTIVES 1. To collect consecutive nonreplicate isolates of Enterobacteriaceae resistant to expanded-spectrum cephalosporins from clinical specimens from inpatients and outpatients. 2. To characterize the isolates for resistance phenotypes and for β-lactam resistance mechanisms. 3. To investigate the clonality of isolates. 4. To analyse the epidemiology of various resistance mechanisms/resistant clones. 5. To collect clinical and epidemiological data for patients with infections caused by the ESBL producers. 6. To analyse the epidemiology, … |
EVELINA TACCONELLI; | 2006-10-01 |
| 468 | Randomized Control Trial of Early Vs Delayed ART in The Treatment of Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cryptococcal Meningitis continues to be one of the most devastating AIDS defining illness in sub-Saharan Africa. Despite the availability of azoles such as fluconazole for treatment, mortality remains high with some studies showing 100% mortality. The investigators designed a study to determine if timing of the initiation of antiretroviral therapy (ART) in patients with cryptococcal meningitis and HIV would improve survival. The investigators hypothesis was that early initiation of ART result in improved mortality for patients with HIV and cryptococcal meningitis. |
CHIRATIDZO NDHLOVU; | 2006-10-01 |
| 469 | A Phase I Safety and Pharmacokinetic Study of Intravenous RTA 744 Injection in Patients With Recurrent, Progressive or Refractory Neoplastic Meningitis Related Papers Related Patents Related Grants Related Experts View Highlight: This study assesses the tolerability, safety, efficacy and pharmacokinetics of RTA 744 in recurrent neoplastic meningitis. |
REATA PHARMACEUTICALS | 2006-10-01 |
| 470 | Amikacin Penetration Into The Cerebrospinal Fluid: Pharmacokinetic/Pharmacodynamic Analysis in Adults With Hospital Acquired Gram-negative Meningitis Associated With Intracranial Pressure Monitoring and Draining Devices Related Papers Related Patents Related Grants Related Experts View Highlight: The limited available data precludes establishing an antibiotic regimen in patients suffering from bacterial meningitis after head trauma, or spontaneous bleeding Understanding the disposition of Amikacin administered intrathecally will enable to propose rational treatment of these patients. |
YEDIDIAH BENTUR; | 2006-09-01 |
| 471 | A Phase I Safety and Pharmacokinetic Study of Intravenous RTA 744 Injection in Patients With Recurrent, Progressive or Refractory Neoplastic Meningitis Related Papers Related Patents Related Grants Related Experts View Highlight: 1. The primary objectives of this study are: 1. To determine the tolerability of RTA 744 Injection in patients with leptomeningeal disease (LMD) secondary to any type of primary tumor. 2. In a selected group of 6-10 patients who will receive RTA 744 at or near the maximum tolerated dose (MTD), to characterize the multiple-dose pharmacokinetics of RTA 744 in plasma and CSF. 2. The secondary objectives of this study are: 1. To document any potential antitumor activity of RTA 744 in this patient population. 2. To correlate pharmacokinetic information with clinical (efficacy and safety) responses, … |
MORRIS D. GROVES; | 2006-09-01 |
| 472 | Evaluation of The Effect of Tetravalent (A, C, Y, W-135) Meningococcal Conjugate Vaccine on Serogroup-Specific Carriage of Neisseria Meningitidis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether the new meningococcal conjugate vaccine (MCV4) can reduce asymptomatic carriage of meningococcal bacteria, and thus decrease the transmission of these bacteria in the population. |
ERIC STERN; | 2006-08-01 |
| 473 | Comparative Study of Two Antibiotic Regimen – Penicillin G/Gentamicin Versus Ampicillin/Gentamicin in Empirical Treatment of Early Onset Neonatal Septicaemia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective two-center antibiotic regimen switch study will be conducted to compare the clinical efficacy of two antibiotic regimens – penicillin/gentamicin versus ampicillin/gentamicin – in the empirical treatment of early onset neonatal sepsis. The influence of either regimen on bowel colonization pattern and on the development of antibiotic resistance of gut microflora will also be assessed. The primary endpoint is the need for a change in antibacterial treatment within 72 hours of therapy, based on pre-defined criteria. Secondary endpoints will be the incidence rate and etiology of early and late onset neonatal sepsis and susceptibility pattern of causative microorganisms; … |
UNIVERSITY OF TARTU | 2006-08-01 |
| 474 | Relationship Between TLR2 Polymorphism and Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Infection with Mycobacterium tuberculosis remains at epidemic levels globally. Innate and adaptive immune responses evolve as protective mechanisms against mycobacterial infection in humans. Toll-like receptors (TLRs) are transmembrane proteins characterized by an extracellular leucine-rich domain that participates in ligand recognition and an intracellular tail. TLRs are the first defense system to detect potential pathogens, initiate immune responses and form the crucial link between innate and adaptive immune systems. Stimulation of TLR initiates a signaling cascade that involves a number of proteins, such as MyD88 and IL-1 receptor-associated kinase. This signal cascade leads to NF-κB activation, … |
MENG-CHIH LIN; | 2006-08-01 |
| 475 | A Multicenter, Randomized Study to Assess The Efficacy and Safety of Mycograb® As Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, efficacy and safety trial to evaluate Mycograb®. Subjects will be randomized to one of the 3 arms: 1/ Amphotericin B (0.7 mg/kg/d) plus 5-flucytosine (100 mg /kg/d); 2/ Amphotericin B plus Mycograb® (dosed 1 mg/kg via a central line or peripheral venous line twice daily for 7 consecutive days); 3/ Amphotericin B plus 5-flucytosine plus Mycograb® (dosed 1 mg/kg via a central line or peripheral venous line twice daily for 7 consecutive days). After 2 weeks, … |
NOVARTIS PHARMACEUTICALS | 2006-08-01 |
| 476 | Urinary Excretion of Enteroviruses From Children With A Presumed Enteroviral Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. Whether Enteroviruses can also affect the kidneys is not known yet. Therefore we will analyze urine of children with a suspected enteroviral infection for enteroviruses and signs of kidney infection. |
ANDREAS PASCH; | 2006-06-01 |
| 477 | Phase I Study of High Dose Gefitinib (Iressa) for The Treatment of Carcinomatous Meningitis in Adult Patients With Non-Small Cell Lung Cancer and Known or Suspected EGFR Mutations Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purposes of this study are to find out if using high doses of the drug Gefitinib (Iressa) as a way to treat patients with non-small cell lung cancer that has spread to the covering of the brain and/or spinal cord (meninges) results in any bad side effects; and to determine the highest dose that can be given to patients in this setting. |
DAVID M. JACKMAN; | 2006-06-01 |
| 478 | Phase II Study of Intrathecal Therapy With DepoCyt for Active Lymphomatous or Leukemic Meningitis Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the response rate of lymphomatous meningitis or leukemic meningitis to DepoCyt. The safety of DepoCyt, the number of people who respond well to the study drug, and the response of symptoms to the study drug will also be determined. |
DAVID RIZZIERI; | 2006-06-01 |
| 479 | Development and Optimization of A GBS Micro Total Analysis System (µTAS) Prototype for The Direct Detection of Group B Streptococci in Vaginal/Anal Specimens From Intrapartum Maternity Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical study is to develop an easily performed test to detect Group B Streptococcus (GBS) in pregnant women at the time of delivery, which would allow health care providers to make an accurate and rapid decision regarding the administration of antibiotics. Administering antibiotics during delivery reduces significantly the likelihood of transmission of GBS, a bacterium that can cause severe life-threatening disease in newborns. Three hundred and twenty pregnant females between 18 to 44 years of age, who are admitted for delivery at the time of consent, … |
MICHEL G. BERGERON; | 2006-05-01 |
| 480 | An Open-Label, Randomized, Multicenter Study of The Safety, Tolerability, and Immunogenicity of V501 Given Concomitantly With Menactra™ and ADACEL™ in Healthy Adolescents 11-17 Years of Age PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Data from this study are expected to demonstrate that V501 (Human Papillomavirus (HPV) [Types 6, 11, 16, 18] Recombinant Vaccine) , when administered concomitantly with a combined diphtheria, tetanus, pertussis (Tdap) vaccine and a meningococcal conjugate vaccine in adolescents remains immunogenic and well-tolerated and it does not impair the immunogenicity of the concomitant vaccines. |
MERCK SHARP & DOHME | 2006-04-01 |
| 481 | Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: All patients who were alive at the end of the dexamethasone treatment trial conducted by Oxford University CLinical Research Unit from 2001-2005 (n=340) will be eligible to participate in this long-term follow-up study. All eligible and consenting patients will undergo an assesment consisting of a simple questionnaire, a clinical examination and a blood test. Data collected will focus on survival, neurological disability and tuberculosis relapse. Data will be collected in individual case record forms and entered into a computer database. |
ESTEE TOROK; | 2006-04-01 |
| 482 | A Phase IV, Single Centre, Open-label Study to Investigate The Kinetics of The B Cell Response to The C Saccharide Component of Chiron’s Meningococcal C Conjugate Vaccine Administered to Healthy Children at Least 12 Months of Age After Priming With A Commercially Available Men ACWY Conjugate Vaccine at 2, 3 and 4 Months of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Persistence of antibodies and kinetics of B cell response in healthy children after vaccination with MCC vaccine |
NOVARTIS VACCINES – INFORMATION SERVICES; | 2006-04-01 |
| 483 | A Randomized, Placebo-Controlled, Double Blind, Phase 1 Trial of The Safety, Immunogenicity, and Tolerability of Ascending Doses of Meningococcal Group B RLP2086 Vaccine in Healthy Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the safety & immunogenicity of a potential vaccine against meningococcal B disease |
TRIAL MANAGER; | 2006-03-01 |
| 484 | NCCLS Interpretive Criteria for Salmonella PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the clinical significance of gene mutations encoding antibiotic resistance, but not expressed as clinical resistance, in Salmonella bacteria |
DAVID PATERSON; | 2006-03-01 |
| 485 | Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The research project is designed to determine which combination of tests will enable physicians to predict whether a patient with symptoms of normal pressure hydrocephalus (NPH) will improve with a shunt. |
LAURA PARE; | 2006-03-01 |
| 486 | Early-Onset Sepsis: An NICHD/CDC Surveillance Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In this observational study, the NICHD Neonatal Research Network (NRN) is conducting surveillance of all infants born at NRN centers to identify all newborns who are diagnosed with early-onset sepsis (EOS) and/or meningitis. The study will: establish current hospital-based rates of EOS among term and preterm infants in the era of intrapartum antibiotic prophylaxis; monitor the organisms associated with EOS and meningitis; compare asymptomatic and symptomatic infants by gestational age and pathogen; and monitor sepsis-associated mortality rates by pathogen group. |
ABBOT R. LAPTOOK; | 2006-02-01 |
| 487 | Therapy-Optimization Trial and Phase II Study for The Treatment of Relapsed or Refractory of Primitive Neuroectodermal Brain Tumors and Ependymomas in Children and Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to improve overall survival while maintaining a good quality of life in pediatric patients with refractory or recurrent brain tumors (medulloblastomas, supratentorial PNETs, ependymomas WHO grade II and III). Response to different chemotherapy options (intravenous versus oral chemotherapy, intraventricular chemotherapy) as part of a multimodal therapy will be assessed. Progression-free, overall survival and toxicity will be evaluated additionally. |
GUDRUN FLEISCHHACK; | 2006-02-01 |
| 488 | A Phase 2, Single-Blind, Controlled, Randomized Study of The Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine ± OMV When Administered at An 0-2-6-Month Schedule in Healthy Adolescents 11-18 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and immunogenicity of two serogroup B meningococcal vaccines in comparison to placebo administered to healthy adolescents ages 11 to 18 years. |
NOVARTIS VACCINES | 2006-02-01 |
| 489 | Phase I Study of Temozolomide and Intrathecal DepoCyt in Patients With Neoplastic Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: – To determine the safety, tolerability and maximum tolerated dose (MTD) of oral temozolomide using a 7 days on and 7 days off regimen combined with intrathecal liposomal cytarabine (DepoCyt) in patients with neoplastic meningitis from solid tumors and systemic lymphoma. |
MORRIS D. GROVES; | 2006-02-01 |
| 490 | A Randomised Open Label Phase 4 Study to Evaluate The Safety and Immunogenicity of Concomitant Prevenar and Meningitec Compared to Prevenar Alone and Meningitec Alone When Used As Part of The Routine Vaccination Series in Healthy Infants PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and immunogenicity of concomitant Prevenar and Meningitec compared to Prevenar alone and Meningitec alone when used as part of the routine vaccination series in healthy infants |
WYETH IS NOW A WHOLLY OWNED SUBSIDIARY OF PFIZER | 2006-01-01 |
| 491 | A Phase III, Multicenter, Open-Label Study To Evaluate The Efficacy, Safety, and Pharmacokinetics of Gammaplex® in Primary Immunodeficiency Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to see if GAMMAPLEX is efficacious with respect to Food and Drug Administration (FDA) minimal requirements (no more than 1 serious, acute, bacterial infection per subject per year) in subjects with Primary Immunodeficiency Diseases (PID). The secondary objectives are to assess the safety and tolerability of GAMMAPLEX and to determine if GAMMAPLEX has a pharmacokinetic (PK) profile comparable with that of intact Immunoglobulin G (IgG) in subjects with PID. |
MELVIN BERGER; | 2006-01-01 |
| 492 | A Phase II Open and Parallel Safety, Immunogenicity and Reactogenicity Trial of Mencevax ACW135 Polysaccharide Vaccine Comparing Three Groups: 2 – 4 Year, 5 – 14 Year and 15 – 29 Year Old Ethiopians PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary objective: To assess the immunogenicity of the Mencevax ACW135 polysaccharide vaccine at 28 days (+6days) post vaccination in 2-4, 5-14, 15-29 year age groups and compare the immunogenicity between these age groups. Secondary Objectives: – To estimate the incidence of common adverse events following immunization (AEFI) of GSK Nm ACW135 polysaccharide vaccine at 1h, 1d, 2d, 3d, 7d and 28 days post-vaccination – To assess the persistence of antibody against meningitis A, C and W135 at 11 and 23 months post vaccination in 2-4, 5-14, 15-29 year age groups Study site:Two rural communities (Kebele) in Butajira district, … |
ABRAHAM ASEFFA ASEFFA; | 2005-11-01 |
| 493 | A Phase I Pharmacokinetic Optimal Dosing Study of Intrathecal Topotecan for Children With Neoplastic Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To find the optimal dose of topotecan that can safely be given directly into the spinal fluid (called intrathecal administration) of children whose cancer has spread to the lining of the brain and/or spinal cord. 2. To find out what effects (good and bad) topotecan has when given directly into the cerebrospinal fluid in children with neoplastic meningitis (cancer that has spread to the lining of the brain and spinal cord). – … |
SUSAN BLANEY; | 2005-10-01 |
| 494 | A Phase I Study of Intrathecal Rituximab in Patients With Lymphomatous Meningitis Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to define the safety profile of rituximab given intrathecally in lymphomatous meningitis related to CD20+ non-Hodgkin’s lymphomas. |
INTERNATIONAL EXTRANODAL LYMPHOMA STUDY GROUP IELSG | 2005-09-13 |
| 495 | Randomised Controlled Trial of Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than improve outcome, because drug interactiond and toxicities or development of an intracerebral immune reconstitution inflammatory syndrome (IRIS). Conversely, delaying ART may result in increased HIV-related deaths. To answer this question, we are conducting a randomised, double-blind placebo-controlled trial comparing immediate and deferred ART in HIV-infected patients presenting with TBM, to assess effect on survival. |
ESTEE TOROK; | 2005-09-01 |
| 496 | DuraSeal Sealant Post Market Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: DuraSeal Dural Sealant has been approved as a dural sealant by the FDA for use in cranial and spinal procedures. This study was completed to further evaluate the safety of the DuraSeal Sealant in a post-approval setting as compared to control (defined as methods typically employed by surgeons to seal the dura). |
INTEGRA LIFESCIENCES | 2005-09-01 |
| 497 | The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Systemic corticosteroids are considered in patients with an adverse clinical course suffering from conditions like the acute respiratory distress syndrome (ARDS) and septic shock. Treated patients not only show improved respiratory function, but also hemodynamic status and overall multiple organ dysfunction score. Objective: To evaluate the safety and effectiveness of 6-methyl-prednisolone on the clinical course of multiple organ dysfunction syndrome (MODS). Design: Multi-center, double-blind, randomized, … |
RAUL DE PABLO; | 2005-08-01 |
| 498 | A Phase I Study Evaluating The Safety and Immunogenicity of A New TB Vaccine, MVA85A, in Healthy Volunteers Who Are Latently Infected With Mycobacterium Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to evaluate the safety of MVA85A in healthy volunteers in the UK who are latently infected with M.tb. A single vaccination with MVA85A, when administeredat a dose of 5 x 107pfu intradermally, is safe in both mycobacterially naïve individuals and those previously vaccinated with BCG. We will use the same vaccination regime in this study. Subjects will be defined as being latently infected if they have a positive elispot response to ESAT6 or CFP10. Subjects will be identified from TB contact clinics. |
HELEN MCSHANE; | 2005-08-01 |
| 499 | A Phase I Pharmacokinetic Optimal Dosing Study of Intraventricular Topotecan for Children With Neoplastic Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. PURPOSE: This phase I trial is studying the side effects, best way to give, and best dose of topotecan when given by intraventricular infusion in treating young patients with neoplastic meningitis due to leukemia, lymphoma, or solid tumors. |
PEDIATRIC BRAIN TUMOR CONSORTIUM | 2005-08-01 |
| 500 | Parenteral Corticosteroids As Adjuvant Therapy for Migraine Headaches PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Migraines are a specific type of headache that frequently recur and are very painful. Although there are many medications that are effective against migraines, none of these medications cure 100% of migraines. Another problem with migraines is that although many times they get better after intravenous (IV) treatment in the emergency room (ER), about 1/3 of the time migraines recur the next day. The purpose of this research project is to see if adding a medication called dexamethasone to standard ER therapy will help patients get better quicker and stay pain-free more often than if they receive placebo. |
BENJAMIN W. FRIEDMAN; | 2005-07-01 |