Clinical Digest: Recent Clinical Trials on MRSA
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to MRSA. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on MRSA
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Infectious Complications, Associated Factors, and Prognosis After Esophagectomy for Cancer: A French, Multicenter, Retrospective Study – CIFO-study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Infectious complications represent the most common postoperative adverse events following esophagectomy for cancer, such as pneumonia (15% of cases). These complications increase immediate risks, lengthen hospital stays, and worsen patient quality of life. The population includes patients admitted to intensive care after esophagectomy for cancer between January 1, 2017, and December 31, 2024. The study focuses on this population due to the increasing incidence of esophageal cancer, the increased use of surgery for these indications, and the importance of postoperative infections in these complex procedures, … |
FRANÇOIS DEPRET; | 2025-04-15 |
| 2 | Phase 2 Study to Evaluate The Efficacy and Safety of TRL1068 for The Treatment of Chronic Prosthetic Joint Infection of The Knee or Hip Without Exchange Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making pathogens substantially more susceptible to established antibiotic treatment regimens. This Phase 2 study is designed to assess efficacy and safety of TRL1068 in combination with a DAIR (debridement, antibiotics, and implant retention) procedure for chronic prosthetic joint infections of the knee and hip, specifically, eliminating the need for the standard of care 2-stage exchange surgery, so that the original prosthesis can be retained. |
TRELLIS BIOSCIENCE | 2025-04-08 |
| 3 | Steriwave ICU Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, non-blinded, prospective, pilot study enrolling patients admitted to the critical care unit at Royal Columbian Hospital. This study investigates the effects of universal nasal decolonization using antimicrobial photodynamic therapy (aPDT) on the prevention of hospital-acquired pneumonia (HAP), ventilator-acquired pneumonia (VAP), and hospital-acquired bloodstream infection (BSI) in this patient population. Main Objectives include: * To determine whether a large, multi-center RCT of this protocol is feasible * To determine baseline rates of VAP, HAP, and ICU-acquired BSI * To gather preliminary efficacy data regarding VAP, HAP, … |
STEVE REYNOLDS; | 2025-03-31 |
| 4 | A Prospective Interventional Randomized Placebo-controlled Multicenter Clinical Trial of The Efficacy, Tolerability and Safety of Phage Therapy in Combination with Standard Antibiotic Therapy in Patients with Infective Endocarditis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Infective endocarditis (IE) is an endocardial lesion caused by bacterial and/or fungal infection that most commonly affects the heart valves and/or the endocardium around implanted intracardiac devices. In general, IE is classified as a rare disease, but there has been a steady increase in incidence, … |
UNIVERSITY CLINICAL HOSPITAL NA V V VINOGRADOV BRANCH OF RUDN UNIVERSITY NA PATRICE LUMUMBA | 2025-02-05 |
| 5 | A Multi-national, Prospective, Randomized, Double Blinded, Placebo-controlled Trial to Evaluate Cyclical Topical Wound Oxygen Therapy (TWO2) in The Treatment of Chronic Venous Leg Ulcers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy, safety and economic benefits of Cyclical Pressure Topical Wound Oxygen (TWO2) Therapy in the treatment of venous leg ulcers. Participants will utilize standard of care (SOC) multilayer compression dressings with an inactive wound contact layer. Following a 2-week run-in period with SOC and after meeting all eligibility criteria, subjects will be randomized in a 1:1 ratio with TWO2 therapy or sham control therapy plus SOC. Participants will enter the intervention period of up to 16-weeks, followed by a long-term follow-up period of 52 weeks post randomization. |
ANIL HINGORANI; | 2025-01-01 |
| 6 | Gut Microbiome in Orthopaedics: Effect of Probiotics on Initial Implant Migration and Joint Inflammation After Total Knee Replacement Related Papers Related Patents Related Grants Related Experts View Highlight: Patients having knee replacement surgery regularly experience joint pain and compromised bone quality leading to implant loosening and periprosthetic fractures. The role of the gut microbiome, which is the collection of bacteria and other microbes within the human gastrointestinal tract, is just beginning to be recognized, including its potential effects on pain, infection, and loosening after total joint replacement. Antibiotics are regularly used in orthopaedic surgery to reduce the risk of infection, … |
BRENT LANTING; | 2025-01-01 |
| 7 | Evaluation of The Decolonization Rate and Acceptance of A Complete Nasal Decolonization Kit With Povidone Iodine for MRSA Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphylococcus aureus (S. aureus) is a leading cause of healthcare-associated infections worldwide. S. aureus colonizes several body sites, including the nose, throat, and perineum. Colonization by methicillin-resistant S. aureus (MRSA) increases the risk of infection by up to 27%, with infecting strains matching colonizing strains in up to 86% of cases. Decolonization, the goal of which is to decrease or eliminate bacterial load on the body, … |
DIDIER LEPELLETIER; | 2024-11-21 |
| 8 | Adjunctive Fosfomycin for Treatment of Staphylococcus Aureus Bacteraemia: Protocol for A Pooled Post-hoc Analysis of Two Randomised Clinical Trials PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphylococcus aureus bacteraemia is a frequent and life-threatening infection, despite current standard antibiotic monotherapy. This study aims to clarify the role of fosfomycin as an adjunctive therapy for improving outcomes in patients with this serious infection. Two clinical trials suggested that adjunctive fosfomycin therapy might offer a clinical benefit in certain cases, but the results are inconclusive. We aim to analyse pooled data from these trials in order to identify subgroups of patients that might benefit most from this therapy. |
FRANCESC ESCRIHUELA-VIDAL; | 2024-11-01 |
| 9 | Preventive Antibiotic Treatment Before Insertion or Exchange of Tunneled Cuffed Catheters in Hemodialysis Patients to Prevent Early Catheter-Related Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine if prophylactic antibiotic treatment can reduce the incidence of early catheter-related infections in hemodialysis patients at high risk, including those with femoral catheter placement, atrial fibrillation, or heart failure. The main questions it aims to answer are: 1. Will prophylactic antibiotic administration reduce catheter-related infections by 50% within 45 days of catheter insertion? 2. Will this intervention decrease the rate of secondary complications such as metastatic infections, cardiovascular morbidity, and mortality? Researchers will compare patients receiving prophylactic antibiotics (e.g., cefamezine and gentamicin, … |
ETTY KRUZEL-DAVILA; | 2024-10-28 |
| 10 | Effectiveness of Local Instillation of Antibiotics Compared to Systemic Antibiotics, As Adjunct to Ultrasound Guided Aspiration in The Management of Breast Abscess; A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Breast abscess, marked by localized collection of pus, frequently follows mastitis. Its prevalence soars up to 16% in the developing world. It usually presents in lactating mothers but also develops in prepubertal females as well. Conventionally it has been treated by surgical incision and drainage with antibiotic coverage, whether oral, intramuscular or intravenous. This approach requires hospital stay and general anesthesia but also have complications like scarring and disfigurement. With the financial and emotional impacts of this technique , … |
ARSLAN ANWAR; | 2024-10-01 |
| 11 | Influencing Factors of Vancomycin Trough Level in Critically Ill Children With Sepsis: A Single-Center Experience PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the work will be to measure the vancomycin trough concentration in critically ill children with sepsis in pediatric intensive care unit and its influencing factors. |
AMANY MOHAMMED EL-REBIGI; | 2024-06-01 |
| 12 | Boosting Knowledge, Attitudes, and Practices: An Experimental Study Evaluating The Effectiveness of MHealth Training on Antimicrobial Resistance for Hemodialysis Nurses PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: To evaluate the impact of an m-health training program on nurses’ knowledge, attitudes, and practices concerning antimicrobial resistance (AMR) within hemodialysis units. Design: This study utilized a controlled experimental design with cluster random assignment, adhering to the Consolidated Standards of Reporting Trials (CONSORT) guidelines. Method: A convenience sample of 64 nurses was cluster-randomized into either an experimental group (n = 32) or a control group (n = 32). The experimental group received AMR education via WhatsApp using Chabot software, while the control group received the same content through leaflets. The nurses’ knowledge, attitudes, … |
HOSSAM NAJJEM ALHAWATMEH; | 2024-06-01 |
| 13 | Swab Testing to Optimize Pneumonia Treatment with Empiric Vancomycin (STOP-Vanc) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for critically ill adults with community-acquired pneumonia when compared with usual care. |
JEFFREY A FREIBERG; | 2024-04-03 |
| 14 | False Positive Peripheral Blood Culture in Children With Leukaemia: A Prevalence Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chemotherapy, the main treatment for childhood leukemia, has side effects on healthy cells. One of the most important of these side effects is the risk of infection due to neutropenia. In clinics, blood culture is the gold standard for the detection of possible infection risk (bacteremia, fungemia, etc.). During the diagnosis and treatment process in children with leukemia, a large number of peripheral or catheter blood cultures are performed. When the culture results are positive, it is accepted that the infection has grown. In some cases, … |
SEDA ARDAHAN SEVGİLİ; | 2024-03-15 |
| 15 | A Clinical Data-Based Model for Drug Concentration Prediction of Vancomycin in Critical Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: This study aims to use machine learning methods to establish an optimal model for predicting serum vancomycin trough concentrations in critically ill patients. Methods: This is a single-center, retrospective study. Data on serum vancomycin concentration in the Critical Care Database of Peking Union Medical College Hospital were screened and extracted to construct a prediction model using machine learning methods. The MIMIC-IV (Medical Information Mart for Intensive Care) database will be further used for external verification of the constructed model. The study has been approved by the Medical Ethics Committee of Peking Union Medical College Hospital (K24C1161). |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2024-03-01 |
| 16 | Rapid De-escalation of Anti-MRSA Therapy Guided By S. Aureus Nares Screening in Case of Pneumonia (SNAP Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The current IDSA/ATS guidelines recommend Linezolid and Vancomycin for MRSA coverage in hospitalized patients with pneumonia, which is common clinical practice in Italy. However, a nasal PCR-assay for MRSA has a high negative predictive value and can facilitate rapid antibiotic de-escalation, thereby avoiding unnecessary anti-MRSA treatments. The indiscriminate use of these drugs has contributed to the emergence of resistant S. aureus strains and has led to significant adverse effects, without providing any survival benefits. Additionally, … |
FRANCESCO VLADIMIRO SEGALA; | 2024-02-10 |
| 17 | Impact of Nasal Antisepsis on Candida Auris Colonization PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, controlled, open-label trial of effect of 10% povidone iodine intranasal antisepsis on the detection of Candida auris. |
MARY K HAYDEN; | 2024-01-29 |
| 18 | Prevalence and Associated Mortality of Infections By Multidrug-Resistant Organisms in Adults Intensive Care Units in Argentina (PREV-AR) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Observational 24-hr point prevalence study with longitudinal follow-up at 164 ICUs in Argentina. All adult patients (aged ≥18 years) at a participating ICU on November 24-28, 2023 with 60- day follow-up, were included. Epidemiological variables, sites of infection, isolated microorganisms, CPE colonisation, and hospital characteristics were collected. Main outcome measure was ICU mortality. |
MARIA INES STANELONI; | 2023-11-24 |
| 19 | Efficacy & Health Economics of Antimicrobial-impregnated Central Venous Catheters (CVCs) Compared to Non-impregnated CVCs in Central Line-associated Bloodstream Infection Prevention in A Malaysia University Hospital Adult ICU PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Central venous catheters (CVCs) are indispensable in modern critical care. However, CVC usage is associated with complications, including central line-associated bloodstream infections (CLABSIs), which in turn, is translated to higher healthcare costs and mortality. The use of antimicrobial-impregnated CVCs is one of the strategies to reduce CLABSI. Nevertheless, its’ efficacy and beneficial effects, particularly in terms of patients’ outcome had not been homogeneously demonstrated across literature. Moreover, antimicrobial-impregnated CVCs are more expensive compared to conventional non-impregnated ones, and hence its cost-effectiveness remains doubtful. To date, … |
TAN KAI MING; | 2023-07-01 |
| 20 | A Randomized Trial Investigating The Superiority of TDM-optimized Teicoplanin Dosing Versus Standard of Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Value of TDM for teicoplanin is not well defined. In this single-center low-interventional randomized trial the investigators aim to investigate the superiority of teicoplanin TDM-optimized using Model-Informed-Precision-Dosing (MIPD) of unbound concentrations versus the standard of care (dosing based on antibiotic guidelines) in target attainment. |
NYNKE JAGER; | 2023-07-01 |
| 21 | Don’t Treat Ghosts: Anti-MRSA Antibiotics in Osteomyelitis Without Identified MRSA PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteomyelitis is described as infection and inflammation of the long bone or bone marrow, often due to an open wound, operation, or invasive trauma.1 It is invasive and involves hematogenous seeding or contiguous spread of the infectious organism |
MATTHEW CROTTY; | 2023-06-23 |
| 22 | Effect of IN Hospital PCR Based Assessment of Patients With Lower Respiratory Tract Infections on LEngth of Stay – INHALE Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Does the use of the BIOFIRE® FILMARRAY® Pneumonia Panel plus in hospitalized patients with lower respiratory infections lead to a reduction in length of hospital stay (LOS) and customized antibiotic treatment (higher amount of specific vs empiric treatment, shorter treatment duration, less antibiotic treatment, lower incidence of side effects) compared to the standard of care? |
ALEXANDER ZOUFALY; | 2023-05-10 |
| 23 | Clinical Study to Improve The Quality of Care in Critically Ill Patients With Suspected Sepsis Through Early Molecular Diagnosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Single-center, retrospective observational study to evaluate the implementation of early molecular diagnosis of sepsis using SeptiCyte and BCID2 in 120 critically ill patients with suspected sepsis without clear focus and requiring antimicrobial treatment. The main objective is to evaluate the performance of these molecular techniques with respect to routine clinical practice and their impact on the optimization of antimicrobial treatment in this group of patients. |
ALEJANDRO RODRIGUEZ OVIEDO; | 2023-04-12 |
| 24 | Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Intravenous vancomycin is considered first line therapy for serious methicillin-resistant Staphylococcus aureus (MRSA) infections including bacteremia, central nervous system infection, pneumonia, pleural space infection, bone or joint infection, prosthetic joint infection and deep abscesses. The effectiveness and toxicity of vancomycin depend on its dosing and chosen target. The most recent guidelines suggest targeting area under the curve over 24 hours over minimum inhibitory concentration (AUC/MIC) of 400 to 600. Implementation of AUC/MIC requires Bayesian software that can be variable, costly, complicated and time consuming. Ideally, AUC/MIC dosing would also require susceptibility testing by broth microdilution, … |
ANTHONY D BAI; | 2023-03-20 |
| 25 | Cost-effectiveness Analysis of An Antimicrobial Stewardship Program in Regione Lombardia: Finalizzata Di Rete 2018 PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Cost-effectiveness analysis of an Antimicrobial Stewardship program in Regione Lombardia: RF-net2018 is a prospective, experimental, multicenter, pre-post study, whose objectives are the evaluation of the efficiency of economic resources allocated to the antimicrobial stewardship program (AMS) in patients with infection and in patients with infections caused by carbapenem-resistant gram-negative (CR-GN) bacteria, identified in a network of 18 hospital facilities participating in our study. Moreover, … |
ANDREA GORI; | 2023-03-01 |
| 26 | Skin Immunity Sample Collection Involving Blisters and Biopsies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The way the body heals and protects itself from getting sick is called the immune response. Some people with weak immune systems get sick often or get rashes and skin infections. Researchers want to find out how the immune system and skin problems are related so they can help these people. Objective: To learn about how immune response and skin healing are related to each other. Eligibility: People ages 18-65 with hyper IgE syndrome or Job syndrome or people ages 7-65 with chronic granulomatous disease. Healthy volunteers ages 18 65 are also needed. Design: Participants will be screened with: Medical history Physical exam Possible urine tests Participants will have 1 to 3 visits within about a week. Visits will include the following: Participants will have a wells device strapped to the inside of the forearm. It will suction the skin and pull the top layer away to form 8 blisters. The skin over the blisters and the liquid inside will be collected. Participants will have up to 4 skin biopsies. A sharp tool will remove a small plug of skin from the forearm. Participants may have blood and urine tests. The skin on participants skin will be rubbed with a cotton swab. Some participants will have an overnight visit. They will have the blister device placed back on the arm. The wells will be lined up over the blister wounds. The wells will be filled with either saline or the participant s blood serum. The device will be covered and left on the arm for up to 24 hours. Doctors will periodically remove some liquid from the wells. |
IAN A MYLES; | 2023-02-21 |
| 27 | Determining The Impact of Enhanced Daily Disinfection on Environmental Contamination in Acute Care Hospital Rooms: A 3-arm Multicenter Blinded Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if enhanced daily application of disinfectant with persistent 24-hour activity decreases the environmental bioburden compared to standard practice. |
DEVERICK ANDERSON; | 2023-02-13 |
| 28 | The Use of Steri3X for Prevention of Post-operative Wound Infections in Cesarean Sections PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Postpartum infection if a major cause of maternal morbidity and mortality and surgical site infections are some of the common complications following cesarean section. This study aims to determine the effect of Steri3X on the incidence of cesarean section SSI at Regional One Hospital. |
RAMONA PHINEHAS; | 2023-02-07 |
| 29 | Effect of Using of Ozone-based Eye Drops As Adjuvant Therapy in The Management of Microbial Keratitis in Comparison to The Conventional Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the therapeutic effect of ozone-based eye drops as an adjuvant therapy to that of the conventional topical antimicrobial agents in patients with microbial keratitis . The therapeutic response will be evaluated with clinical examination follow up . |
ABEER ABDEL-FATTAH MOHAMMED ALI; | 2023-01-01 |
| 30 | Safety and Efficacy of An Oral Penicillin Challenge in Low Risk Hospitalized Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Penicillin allergy is the most common drug allergy reported by patients. Approximately 10% of the population and 20% of inpatients carry a label of penicillin allergy. However, … |
ANDREA FONG; | 2022-12-01 |
| 31 | Prospective Evaluation of Xerava™ (Eravacycline) Prophylaxis in Hematological Malignancy Patients With Prolonged Neutropenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Antibacterial prophylaxis is recommended in patients at high risk of infection, specifically patients undergoing acute leukemia induction therapy or hematopoietic stem cell transplant (HSCT) who are expected to have profound neutropenia (ANC<100 neutrophils/milliliter) for more than seven days. Xerava™ (eravacycline) has a broad spectrum of activity including many multi-drug resistant strains of bacteria. It is not an agent used for treatment of febrile neutropenia, making eravacycline a very attractive alternative to consider in this prophylactic setting. Eravacycline has activity against MRSA, VRE, and Clostridioides difficile, ... |
AARON CUMPSTON; | 2022-10-01 |
| 32 | A Prospective Single-blind Placebo-controlled Trial to Establish The Efficacy and Tolerability of 10% Povidone-Iodine for Nasal S. Aureus and Methicillin Resistant Staphylococcus Aureus (MRSA) Decolonization Among Patients Undergoing Same-day Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and tolerability of 10% povidone-iodine in eliminating nasal carriage of Staphylococcus aureus and MRSA. To determine whether a more convenient, single-dose, pre-operative 10% povidone-iodine (PI) application is effective in reducing nasal carriage of S. aureus and MRSA. We expect a statistically significant decrease in S. aureus/MRSA colonization in nasal cultures taken perioperatively after intervention in patients who received pretreatment with PI as compared to patients who received normal saline (NS). |
DENNIS GRECH; | 2022-09-06 |
| 33 | Efficacy and Safety of Hemp-derived, Full Spectrum Cannabigerol (CBG) in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to provide exploratory research into the in vivo physiological and psychological effects, if any, of cannabigerol (CBG) in healthy human adults age 21 or over. The main questions it aims to answer are: * What effect, if any, does daily oral consumption of 50mg of full spectrum CBG have on the mental, physical, and emotional wellbeing of healthy individuals, as measured by self-report Medical Symptom Questionnaire and 36-Item Short Form Health Survey scores? * Is CBG effective at reducing inflammation in the body, as measured by HSCRP, ESR, … |
CORY RICE; | 2022-08-01 |
| 34 | MRSA Decolonization in Complicated Carriage – Cluster Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicenter open-label cluster randomized controlled trial determining the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRSA carriership. |
MEREL LAMBREGTS; | 2022-07-25 |
| 35 | Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia (CERT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is a variety of in vitro, in vivo (animal model), and human case series data which suggests that the addition of ertapenem to cefazolin could improve outcomes in methicillin-susceptible S. aureus bacteremia. No randomized controlled trial has been performed. |
TODD C LEE; | 2022-07-01 |
| 36 | Efficacy of Infection Control Program on Reducing Tracheostomy Tube Colonization With Biofilm Producing Antimicrobial Resistant Bacteria PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Healthcare-associated infections are infections that patients acquire during the course of receiving treatment for other conditions within a healthcare setting and are not present at the time of admission. Medical instrumentation increases the risk of development of HAIs. Such devices include, venous and urinary catheters, and ventilators. Most ventilator-dependent patients undergo respiratory stabilization with an endotracheal tube in a critical care setting. Later on, translaryngeal tubes are converted to a tracheostomy to provide long-term airway access for ventilatory support. Tracheostomy is a commonly performed airway surgery for critically ill patients. It has variable complications, … |
HANAA AREF; | 2022-06-01 |
| 37 | Evaluation of The Tolerability, Safety of Use, and Efficacy of Cosmetic Products for The Oral Care. In Use Test Under Dentist Control PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this open-label, randomized controlled clinical trial, is to provide preliminary clinical data (efficacy on plaque and gingival sensitivity, and safety and tolerability of two types of toothpaste, a mouthwash, and a specifically custom-designed toothbrush used for 28 days), … |
DARIO CATTANEO; | 2022-05-17 |
| 38 | A Multicenter, Double-blinded, Randomized, Parallel Design, Phase IIa Clinical Trial to Evaluate The Efficacy, Safety and PK of LCB01-0371 With Vancomycin Versus Vancomycin Monotherapy in Patients With MRSA Bacteremia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this study is to exploratory whether vancomycin + delpazolid is more effective to the standard of treatment (vancomycin)/ for hospitalised adults with MRSA bacteraemia. |
LEGOCHEM BIOSCIENCES | 2022-04-26 |
| 39 | Effect of Expanding Barrier Precautions for Reducing Clostridium Difficile Acquisition in VA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Clostridium difficile (C. difficile) is a major pathogen causing serious healthcare-associated diarrheal illness in patients. Prevention of healthcare facility-onset C. difficile infection (CDI) is essential. Many CDI cases are caused by the transmission of the pathogen from patients who carry the bacteria, but do not have symptoms. However, there are limited data on how to prevent the transmission of C. difficile from patients who do not have symptoms. Universal gloving practices – the use of gloves by all healthcare workers for all patient contacts – may reduce CDI cases. In this study, … |
NASIA SAFDAR; | 2022-03-29 |
| 40 | The Impact of Hospital Care for COVID-19 on The Prevalence of Multidrug-resistant Microorganisms Among Patients Compared to Non-COVID-19 Hospital Care in Limited-resource Hospitals in Indonesia PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The effect of the COVID-19 pandemic on the emergence and spread of antibiotic-resistant bacteria is largely unknown, especially in low-resource settings. We aim to investigate the prevalence and relatedness of multidrug-resistant bacteria among patients in both COVID-19 and non-COVID-19 wards in two hospitals in Indonesia. Bacterial isolates will be collected from clinical sample and by screening of patients at discharge followed by 30 days after discharge. Aspects of hospital care that may be different in COVID-19 wards versus non-COVID-19 wards and that are considered important determinants for antimicrobial resistance (AMR) will be measured: hand hygiene compliance, … |
JULIËTTE SEVERIN; | 2022-03-07 |
| 41 | A Phase 1, Open-Label, Randomized, Crossover Study to Assess The Safety and Pharmacokinetics Following Single Doses of Oral and Intravenous Xenleta (Lefamulin) in Adult Patients With Cystic Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is intended to assess the PK and safety of a single dose of IV and oral formulations of lefamulin in adults with CF. |
NABRIVA THERAPEUTICS AG | 2022-03-01 |
| 42 | Improving Carbapenemase-Producing Organism (CPO) and Vancomycin-Resistant Enterococcus (VRE) Management With BD Solutions PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Emergence of vancomycin-resistant enterococci (VRE) and carbapenemase-producing enterobacteria (CPE) is nowadays a major public health concern worldwide. VRE and CPE are referred to as Emerging eXtensively Drug Resistant bacteria (eXDR). A better, faster and more accurate identification of VRE and CPE would allow faster appropriate therapy for patients and/or infection control strategies. Faster appropriate therapy could improve mortality rates, length of stay, and other patient outcomes as well as hospital costs. BD offers a variety of products, services and solutions designed to increase efficiency, streamline processes, … |
SANDRINE BOISSET; | 2022-02-18 |
| 43 | Bacterial Eradication of The Nasal Epithelium From Infectious Toxins With PDT (BENEFIT-PDT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2 single-center, open-label, single-arm, study of a microbiological endpoint using antimicrobial photodynamic therapy (aPDT) for nasal disinfection in all patients (universal) presenting for surgery at an acute care hospital for a wide range of surgical procedures. |
STEPHEN A. THACKER; | 2022-02-04 |
| 44 | Nasopharyngeal Bacterial Carriage and Antibiotic Resistance in Children With Sickle Cell Disease in Ile-De-France PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to to determine the rate of nasopharyngeal carriage of Streptococcus pneumoniae (Sp) in children with sickle cell disease over 6 months and under 15 years of age over a 9-month period in Ile-De-France. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-02-01 |
| 45 | Prevalence of Multidrug Resistant Micro-organism Carriage in Patients Undergoing An ERCP in Four Different Countries PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The duodenoscopes currently used for ERCP (Endoscopic Retrograde Cholangio – and Pancreaticography) examinations are reusable and are therefore washed and disinfected after each use. Despite this, these endoscopes sometimes remain contaminated with bacteria. Several reports of outbreaks linked to contaminated duodenoscopes have been published worldwide. Recently, the FDA advised manufacturers and health care professionals to transition away from fixed endcap duodenoscopes and instead focus more on the use of duodenoscopes with disposable components or fully disposable duodenoscopes. Single-use endoscopes have been developed, but they are not yet widely used, … |
MARCO J. BRUNO; | 2022-01-31 |
| 46 | Microbiological Assessment of Air and Surfaces of Operation Rooms in Assuit University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To determine the bacteriological load on air and surfaces within the ORs. 2. To isolate and identify pathogenic strains of bacteria on equipments and contact surfaces. 3. To compare between adenosine triphosphate bioluminescence assay and the ordinary cultures in order to verify whether the methods of hygienization and disinfection implemented were in fact effective. |
ESRAA HUSSIEN MAHRAN SHEHATA; | 2021-12-01 |
| 47 | Comparative Efficacy of Intravenous Cefuroxime and Ceftriaxone in Preventing Surgical Site Infection After Neurosurgical Procedures PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay. The appropriate and timely use of prophylactic antibiotics is found to reduce the prevalence of SSIs. At present, several regimen of antimicrobial agents are used in neurosurgical procedures since the choice of appropriate antibiotic agent is not fully established. Cephalosporins are among the frequently used antibiotics for prophylaxis in neurosurgical procedures, with studies comparing first and second generation Cephalosporins to third generation in neurosurgical prophylaxis, … |
PROMISE TAMUNOIPIRIALA JAJA; | 2021-12-01 |
| 48 | A Randomized Double-blind Controlled Clinical Trial Comparing A Synergistic Antimicrobial Cleanser and Gel to Normal Saline and An Amorphous Gel in Reducing Bioburden and Promoting Healing in Chronic Lower Extremity Ulcers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a randomized double-blind controlled clinical trial designed to compare healing rates between normal saline wash in combination with an amorphous gel (NSS-HG) versus the grouping of a synergistic antimicrobial cleanser (AMC) and antimicrobial gel (AMG) in chronic lower extremity ulcers. After consenting, the ulcers of eligible subjects are measured, … |
SERENAGROUP | 2021-12-01 |
| 49 | Effect of Antibiotic Choice On ReNal Outcomes (ACORN) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Sepsis is one of the most common causes of acute illness and death in the United States. Early, empiric broad-spectrum antibiotics are a mainstay of sepsis treatment. Two classes of antibiotics with activity against Pseudomonas, anti-pseudomonal cephalosporins and anti-pseudomonal penicillins, are commonly used for acutely ill adults with sepsis in current practice. Recent observational studies, however, have raised concern that anti-pseudomonal penicillins may cause renal toxicity. Anti-pseudomonal cephalosporins, by comparison, may be associated with a risk of neurotoxicity. Rigorous, … |
EDDIE QIAN; | 2021-11-10 |
| 50 | NAsal MEthicillin-resistant Staphylococcus (NAMES): A Prospective Study to Assess The Impact of Antibiotic Therapy on Nasal Colonization with Methicillin-resistant Staphylococcus Aureus (MRSA) in Hospitalized Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Antimicrobial resistance (AMR) is recognized as one of the major threats to global health \[1\], causing up to 25.000 deaths in the European Union every year, longer hospitalizations and increased healthcare costs. It is well known that antimicrobial use is the main driving force towards AMR and up to 50% of antimicrobial prescriptions are either inappropriate or unnecessary \[2\]. It is then important to understand how to optimize antimicrobial usage not only in adults but also in infants, … |
ALESSANDRA RICCIARDI; | 2021-11-06 |
| 51 | A Study on Plasma and Pulmonary Pharmacokinetics of High-dose Ceftobiprole Given By Continuous Infusion in Mechanically-ventilated Adult Patients With Severe Community-acquired Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the study is to describe plasma pharmacokinetics (PK) and pulmonary diffusion of high-dose ceftobiprole (500 mg loading dose followed by 2.5 g under continuous infusion for 24h) for mechanically-ventilated adult patients with severe community-acquired pneumonia, using population PK modelling. The secondary aims are : A- To determine whether the pharmacokinetic / pharmacodynamic (PK/PD) targets can be achieved in the plasma and epithelial lining fluid with the recommended doses of ceftobiprole. B- To define the optimal dose regimen for ceftobiprole in this population. C- … |
CENTRE HOSPITALIER UNIVERSITAIRE DE NĪMES | 2021-09-01 |
| 52 | Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to find out how Avenova (0.01 % hypochlorous acid) works compared to Betadine (Povidone iodide) for reducing bacteria and patient discomfort in the eyes. |
JORGE FORTUN; | 2021-08-06 |
| 53 | What Happened? Antimicrobial Resistance During The SARS-CoV-2 (COVID-19) Pandemic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Assess the incidence and rates of resistant pathogens prior to and during the COVID-19 pandemic. |
MATHEW CROTTY; | 2021-07-06 |
| 54 | Pharmacokinetics of Omadacycline in Patients With Cystic Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to characterize the pharmacokinetics of intravenous and oral omadacycline in patients with cystic fibrosis. |
PAUL BERINGER; | 2021-07-01 |
| 55 | The Pattern of Antibiotic Prescription for Children Among A Group of Pediatric Dentists PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine the pattern of antibiotic prescription for children among a group of pediatric dentists |
AHMED MOSTAFA ABDO ELGENDY; | 2021-06-01 |
| 56 | A Prospective Cohort Study to Investigate The Transmission and Burden of PVL-MRSA in Households in Sri Lanka PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will determine the frequency of Staphylococcus aureus carriage in household contacts of individuals with clinical infection due to this pathogen. It will also assess the frequency of transmission events over the following three months. Finally it will aim to identify predisposing characteristics both on a demographic/social level as well virulence characteristics of the identified strains. |
THOMAS DARTON; | 2021-05-01 |
| 57 | Vancomycin Monitoring: Is AUC Monitoring Appropriate for More Than Just Serious MRSA Infections? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Vancomycin, a glycopeptide antibiotic, is commonly prescribed as initial therapy for hospitalized patients due to its broad gram-positive coverage. Vancomycin is used for the treatment and prevention of a variety of bacterial infections ranging from streptococcal to methicillin-resistant Staphylococcus aureus (MRSA) infections.1 Notable adverse effects of intravenous vancomycin include nephrotoxicity, ototoxicity and hypersensitivity reactions. Given its pharmacokinetic profile, therapeutic drug monitoring is essential in determining the therapeutic efficacy of vancomycin as well as for avoiding nephrotoxicity. |
AKINS RONDA; | 2021-04-08 |
| 58 | Aged European Population QUality of Life in Infectious Diseases PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The increasing number of persons >65 years of age form a special population at risk for nosocomial and other health care-associated infections. The vulnerability of this age group is related to impaired host defenses such as diminished cell-mediated immunity. Lifestyle considerations, e.g., travel and living arrangements, and residence in nursing homes, … |
UNIVERSITY HOSPITAL GRENOBLE | 2021-04-01 |
| 59 | Pharmacokinetics of New Licensed Antibiotics in Critically Ill Patients Receiving Continuous Venovenous Haemofiltration: An International Collaborative Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The mortality in patients with sepsis and severe acute kidney injury requiring continuous renal replacement therapy (CRRT) remains high. Antibiotic therapy is a key treatment of these patients and in recent years new antibiotics have been licensed. However, data is lacking to determine the optimal dosing regimens of these antibiotics for high (Australia and other countries) and low intensity (Japan) of CRRT. Aim To establish the appropriate dosing regimens of newly available antibiotics during CRRT can applied globally. |
OSAKA UNIVERSITY | 2021-04-01 |
| 60 | A Phase I/IIa, Randomised, Double-blind, Placebo-controlled Study to Evaluate The Safety and Exploratory Efficacy of 3% LTX-109 Compared to Placebo for Nasal Decolonisation of Staphylococcus Aureus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase I/IIa, double-blind, placebo-controlled, randomised study designed to evaluate the safety, tolerability, exploratory efficacy and exposure of LTX-109 administered topically to the anterior nares in subjects with persistent carriage of S. aureus (methicillin-susceptible S. aureus [MSSA] and/or methicillin-resistant S. aureus [MRSA]). |
JOHAN NILSSON; | 2021-02-22 |
| 61 | A Phase 1, Blinded, Single Ascending Dose Study to Evaluate Safety, Pharmacokinetics, and Activity of TRL1068 in Subjects With Prosthetic Joint Infection of The Knee or Hip, Undergoing Primary Two Stage Exchange Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making these pathogens substantially more susceptible to established antibiotic treatment regimens. This initial study is designed to assess overall safety and pharmacokinetics (PK) of TRL1068. The overall goal of the development program is to demonstrate that TRL1068 can facilitate effectiveness of a single stage joint replacement or preservation of the original infected prosthetic joint in a substantial proportion of patients with PJI. |
NICHOLAS BERNTHAL; | 2021-02-08 |
| 62 | Expanded Access Study of A Single Dose of Exebacase in Addition to Antistaphylococcal Antibiotics for The Treatment of Persistent Methicillin-Resistant Staphylococcus Aureus (MRSA) Bloodstream Infections (Including Right Sided Endocarditis) in Patients Who Are Hospitalized With Coronavirus Disease 2019 (COVID-19) Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label, expanded access study of exebacase used in addition to antistaphylococcal antibiotics in adult patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI), including right-sided endocarditis (R-IE), who are hospitalized with coronavirus disease 2019 (COVID-19). Patients with left-sided endocarditis (L-IE) are excluded. Patients will receive a single dose of exebacase. Patients will continue to receive antistaphylococcal antibiotics as prescribed by the treating physician. Exebacase Phase 3 study sites (Study CF-301-105) may participate in this Expanded Access study (Study CF-301-107). Exebacase, a direct lytic agent, … |
CONTRAFECT | 2020-10-20 |
| 63 | CleanHands Sensor Based System to Improve Hand Hygiene and Reduce Infection Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if use of the CleanHands system can improve hand hygiene/personal protective equipment (PPE) compliance and reduce infections in the hospital ICUs through reminders to wash hands and use PPE as appropriate. |
JIAPENG HUANG; | 2020-10-07 |
| 64 | MSSA and MRSA Screening in Patients Undergoing Elective TJA: The Benefits of Next-generation Sequencing PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aims of this study were to evaluate the diagnostic performance of molecular and culture techniques in S. aureus screening using paired nasal and groin swabs, to determine, if any, discrepancy between the diagnostic techniques and to model the potential effect of different diagnostic techniques on S. aureus detection in orthopaedic patients |
ROTHMAN INSTITUTE ORTHOPAEDICS | 2020-08-30 |
| 65 | Non-interventional Observational Study of Daptomycin in The Treatment of Gram-positive Bacterial Infections PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to collect and analyze clinical data of daptomycin to explore the efficacy and safety of daptomycin in the treatment of Gram-positive bacterial infections. And optimize the dosing regimen based on these data. |
XIAOJUN X MA; | 2020-08-25 |
| 66 | Skin Closures at Cesarean Delivery, Glue Vs Subcuticular Sutures: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The optimal choice of skin closure at cesarean delivery has not yet been determined. This study will compare wound complications and scar healing following cesarean delivery between 2 methods of skin closure: glue (Dermabond®; Ethicon, Somerville, NJ) and monofilament (Monocryl®; Ethicon) epidermal sutures. |
AHMED MOHAMMED ELMARAGHY; | 2020-08-25 |
| 67 | Dalbavancin in Real Clinical Practice in Spain: A Two-year Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to describe the real clinical use of Dalbavancin in Spain between January 2018 and December 2019. |
BENITO ALMIRANTE; | 2020-07-15 |
| 68 | Interplay Between Gut Microbiota and Adaptive Immunity in Amyotrophic Lateral Sclerosis: A Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Given the role of adaptive immunity in ALS, the pathogenicity of some clostridial strains on motorneurons, the putative role of cyanobacteria in ALS development, and the increasing interest for microbiota in neurodegenerative disorders, the modification of intestinal microbiota might affect ALS at its core. This interventional study aims at evaluating the biological and disease-modifying effects of Fecal Microbiota Transplant (FMT) in patients affected by Amyotrophic Lateral Sclerosis. As a primary aim of the study, the investigators postulate ALS patients treated with FMT compared to the control arm will display increased Tregs number, … |
JESSICA MANDRIOLI; | 2020-07-01 |
| 69 | Retrospective Effectiveness Study of Dalbavancin and Other Standard of Care of The Same Class (i.v. Lipo and Glyco-peptides) in Patients With ABSSSI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to collect the data on the effectiveness of dalbavancin in terms of save of hospitalization days on patients treated between June 2017 and June 2019 in two countries (Italy and Greece) vs the other Standards of care of the same class (SoC; i.v. lipo and glycopeptides) in a real-life context. Time to discharge from the start of therapy for ABSSSI in the hospital context will be assessed and all relevant data available on patient management, clinical, … |
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S P A | 2020-06-18 |
| 70 | Bactericidal Effect of Silver Nanoparticles on Methecillin and Vancomycin Resistant Staphylococcus. Aureus (MRSA) Isolated From Critically Ill Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Recently, silver nanoparticles (AgNPs) have been widely used in various applications as antimicrobial agents, anticancer, diagnostics, biomarkers, cell labels, and drug delivery systems for the treatment of various diseases. The present study investigated the bactericidal effect of AgNPs against Methecillin Resistant Staph. aureus (MRSA) and Vancomycin resistant Staph aureus (VRSA) |
RASHA HAMED; | 2020-06-01 |
| 71 | A Randomized Placebo-controlled Double-blinded Trial of The Treatment of MRSA Throat Carriage With Either Standard Decolonization Therapy or Standard Decolonization Therapy Combined With Oral Clindamycin PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the optimal way to treat MRSA throat carriers. |
MONA KATRINE ALBERTHE HOLM; | 2020-05-20 |
| 72 | Topical Gentamicin and Vancomycin for Surgical Site Infection Prophylaxis in Patients Undergoing High-Risk Vascular Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Many patients who undergo vascular surgery to improve the blood flow to their legs are at risk of developing an infection in the surgical site and are then at risk of serious complications such as hospital readmission, failure of the surgical procedure and lower limb amputation. Surgical site infections may be reduced in high-risk patients by applying two commonly used antibiotics (gentamicin and vancomycin) into the surgical incision at the end of the surgical procedure. This will be compared to the standard of care treatment at London Health Sciences Center. |
LUC DUBOIS; | 2020-05-01 |
| 73 | Povidone-Iodine Intranasal for Prophylaxis in Front-line Health-care Personnel and Inpatients During The Sars-CoV-2 Pandemic PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Povidone-iodine (PVP-I) is a broad-spectrum antiseptic with activity against bacteria, fungi, and viruses. It has been previously used in both intranasal preparations against Methicillin Resistant Staphylococcus Aureus (MRSA) as well as oral preparations in in-vitro studies of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), influenza H1N1, and rotavirus with good efficacy. This study will evaluate the efficacy of PVP-I as prophylaxis in Coronavirus Disease 2019 (COVID19)-negative front-line health care workers, hospital patients, and community members. |
NIKITA GUPTA; | 2020-04-29 |
| 74 | Cluster Randomized Trial With Cross-over of Targeted Gown and Glove Intervention to Prevent Staphylococcus Aureus and Carbapenem-resistant Gram-negative Bacteria Acquisition in Community-based Nursing Homes Related Papers Related Patents Related Grants Related Experts View Highlight: This project will assess the feasibility of a cluster-randomized trial with crossover of our intervention, targeted gown and glove use, among high-risk residents of community nursing homes to prevent Staphylococcus aureus and carbapenem gram negative bacteria acquisition and infection. |
MARY-CLAIRE ROGHMANN; | 2020-03-01 |
| 75 | Probiotic Bacillus for Decolonization of Methicillin-resistant Staphylococcus Aureus (MRSA) in Patients Undergoing Total Joint Arthroplasty: A Randomized, Prospective, Placebo-Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot study is designed to determine if ingestion of Bacillus probiotics can cause alteration in levels of S. aureus colonization in the nose and intestine in preoperative orthopedic patients undergoing elective primary TJA. |
ROTHMAN INSTITUTE ORTHOPAEDICS | 2020-02-12 |
| 76 | Povidone-Iodine Rinses As An Adjuvant Therapy Post-Operatively: A Double-Blind Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Povidone Iodine solution is a nasal antiseptic. Its application has been shown to be clinically safe, tolerable and effective against bacteria and fungi associated with chronic rhinosinusitis. The purpose of this study is determining the effectiveness of PVP-I in comparison to a placebo for post-operative refractory CRS patients in a randomized controlled trial. |
AMIN JAVER; | 2020-02-10 |
| 77 | Evaluation of The Tolerance of Anti-MRSA Betalactamines (Ceftaroline / Ceftobiprole) in The Management of BJI / PJI: A Retrospective Study in A Reference Center PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphyloccous aureus and coagulase negative staphylocci are responsible of a large marjority of PJI. Regarding the high rate of methicillin resistance, current guidelines recommend the use of a glycopeptide, and most frequently vancomycin, as the anti-gram positive agent in empirical therapy, while awaiting the microbiological results. Vancomycin is not considered as a safe antibiotic, and daptomycin is frequently an alternative option. Ceftaroline and ceftobiprole are the only betalactam active on methicillin-resistant staphylococci. As some data report a synergistic activity with daptomycin, they could be an option in pandrug-resistant staphylococci BJI, but their use if off label in this indication. |
HOSPICES CIVILS DE LYON | 2020-02-01 |
| 78 | A Population PK Study Into Teicoplanin in Intensive Care and Haematology Patients – A Strategy Towards Model Informed Precision Dosing PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Characterize teicoplanin PK in critically ill patients with a specific focus on alterations of exposure due to variability in renal function. In a prospective, observational, open-label study the investigators aim to define PK of free drug concentrations of teicoplanine in ICU and heamatology patients and define a PK model for Bayesian dose individualization. |
RADBOUD UNIVERSITY MEDICAL CENTER | 2020-01-15 |
| 79 | Can Intraosseous Antibiotics Improve The Results of Irrigation & Debridement and Prosthetic Retention for PJI? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose of Study: In order to improve upon the variable results seen in irrigation and debridement for periprosthetic infection, we ask if the use of intraosseous regional administration of antibiotics at the time of irrigation and debridement will improve the modest success of standard irrigation and debridement. We will use the existing literature on standard irrigation and debridement procedures to compare with the results of the irrigation and debridement with the use of intraosseous antibiotics. Impact Question: How will this study benefit the patient? Currently when an I\&D fails, … |
THOMAS FEHRING; | 2020-01-14 |
| 80 | Relation Between Adherence to Hand Hygiene Practices By Healthcare Providers Working in Intensive Care Unit and Microbial Contamination on Feeding Tubes and Other Components of Feeding Systems PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Enteral feeding tube (EFT) and component of feeding systems can serve as a reservoir of microorganisms, and the main reason is inappropriate hand hygiene practices. The aim of the project is to determine colonization of microorganisms on the EFT and other components and assess the relation between colonization and adherence to hand hygiene practices by healthcare workers in the intensive care unit. This prospective, … |
NURTEN OZEN; | 2020-01-02 |
| 81 | Tracing MRSA in Households With Patients Infected With CA-MRSA By WGS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: From the 1980s to the late 1990s, highly toxic methicillin-resistant Staphylococcus aureus (MRSA) strains (called community-associated [CA] MRSA) appeared in the community. Although the prevalence of HA-MRSA (health-related MRSA) infection remained stable between 1998 and 2008, the CA-MRSA (community-related MRSA) infection rate increased. By far, the most common manifestations of CA-MRSA related diseases are skin and soft tissue infections. Skin and soft tissue infections (SSTIs) account for at least 90% of CA-MRSA infections. CA-MRSA strains also cause bone and joint infections, such as osteomyelitis and respiratory infections, such as pneumonia, sepsis, … |
JIAN-CANG ZHOU M.D.; | 2019-11-15 |
| 82 | Investigator Driven Randomized Controlled Trial of Cefiderocol Versus Standard Therapy for Healthcare Associated and Hospital Acquired Gram-negative Blood Stream Infection: Study Protocol (the GAME CHANGER Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of care. |
DAVID PATERSON; | 2019-10-28 |
| 83 | An Open-label, Dose-escalation Study to Evaluate The Pharmacokinetics of Inhaled Teicoplanin in Cystic Fibrosis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cystic Fibrosis (CF) is the most common autosomal recessive lethal disorders affecting 1:2.500 newborns among Caucasians. CF patients are peculiarly susceptible to infection and colonization of the respiratory tract with pathogens. In particular, Methicillin-resistant Staphylococcus aureus (MRSA) has become the third most prevalent bacterium in CF in the U.S. and has been increasing in other countries. Apart from the difficulty of treating the infection because of its antimicrobial resistances, MRSA is transmissible between individuals with and without CF. Chronic MRSA infection is associated with worse outcomes, … |
GIULIA PAIOLA; | 2019-10-25 |
| 84 | Double-blind Clinical Trials of Probiotic Products in Oral Health PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In order to evaluate the effects of supplementary probiotics and their metabolites on oral environment and oral microbiota, Taiwan FDA No. 88037803 will be used to evaluate the effects of oral probiotic candidate strains from previous research results and develop oral probiotic products. |
HSIEH-HSUN HO; | 2019-10-21 |
| 85 | Efficacy of An Antimicrobial Stewardship Intervention for Early Adaptation of Empirical Antibiotic Therapy in High-risk Neutropenic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Febrile neutropenia (FN) is a frequent and serious complication in patients with hematological malignancies undergoing intensive chemotherapy. The growth of antibiotic resistance is a major threat in high-risk neutropenic patients given that delay in introduction of appropriate empirical antibiotic therapy (EAT) in this population is associated with increased morbidity and mortality. In 2013, the 4th European Conference on Infections in Leukaemia (ECIL-4) group published new guidelines, promoting early adaptation of EAT in stable afebrile patients, regardless of neutrophil count and expected duration of neutropenia. Despite these evidence-based guidelines, discontinuation and de-escalation strategies are not widely implemented in hematology departments. However, … |
CENTRE HOSPITALIER UNIVERSITAIRE DE NICE | 2019-10-01 |
| 86 | Measuring The Impact of An Enhanced Strategy for Daily Disinfection in Acute Care Hospital Rooms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effectiveness of an enhanced strategy for daily disinfection in acute care hospital rooms comparing the addition of sani24 to routine daily cleaning versus the control of routine daily cleaning. |
NICK TURNER; | 2019-08-22 |
| 87 | Dissemination and Resistance Mechanisms of Carbapenem-resistant Gram-negative Bacilli and Methicillin-resistant Staphylococcus Aureus in Intensive Care Units in China PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Carbapenem-resistant Gram-negative bacilli [Carbapenem-resistant Acinetobacter baumannii (CRAB), Carbapenem-resistant Klebsiella pneumoniae (CRKP), and Carbapenem-resistant Pseudomonas aeruginosa (CRPsA) ] and methicillin-resistant Staphylococcus aureus (MRSA) is prevalent around the world, and the isolation rate and resistance rate has increasing in China. The limited treatment and high mortality rate of these pathogens infections has resulted in difficulty in clinical anti-infection treatment, so it is urgent to illustrate the transmission mechanism, resistance mechanism and horizontal transfer mechanism of resistance genes in intensive care unit (ICU). Furthermore, this study was aimed to investigate the epidemiology and risk factors, … |
JIAN-CANG ZHOU M.D.; | 2019-08-06 |
| 88 | Remote Physician Care for Home Hospital Patients: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits. |
DAVID LEVINE; | 2019-08-03 |
| 89 | Effect of PCR-CRISPR/Cas12a on The Early Anti-infective Schemes in Patients With Open Air Pneumonia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter randomized controlled trial. The purpose of this study is to assess the efficacy of the combination of PCR and CRISPR/Cas12a in alveolar lavage fluid for early targeted anti-infective therapy for patients with severe pneumonia. Hosted by the Department of Critical Care Medicine, Affiliated Drum Tower Hospital of Nanjing University Medical College, 5 adult ICU units participate in 3 hospitals. All patients are randomly assigned to the experimental group and the control group. For experimental group, the combined detection of PCR and CRISPR/Cas12a in the alveolar lavage fluid was carried out in the early stage, … |
CHINESE MEDICAL ASSOCIATION | 2019-08-01 |
| 90 | Surveillance of Community-Associated MRSA and Treatment Outcomes of Skin and Soft Tissue Infections in The Ambulatory Setting PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to obtain information from patients diagnosed with a skin and soft tissue infection (also known as an abscess or ‘boil’ or ‘rising’) and determine whether or not MRSA is present in the child’s different surface skin areas or nose. We also plan to compare how these infections look in the lab, by identifying in detail parts of the germ that caused the infection or is found on the skin/nose areas |
CHILDREN’S HEALTHCARE OF ATLANTA | 2019-07-14 |
| 91 | Characterization of Ceftobiprole’s Cerebrospinal Fluid Penetration in Patients With External Ventricular Derivation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Cerebrospinal fluid penetration of ceftobiprole has been studied in an animal model of meningitidis. Ceftobiprole is bactericidal, well tolerated and it has anti-biofilm activity. Altogether, these pharmacodynamics and pharmacokinetic properties of ceftobiprole are suitable for its use in case of External Ventricular Derivation(EVD)-related ventriculitis. Nowadays there are no human studies on the penetration and efficacy of ceftobiprole in the CSF. The study aims to evaluate characteristics of the CSF penetration of Ceftobiprole after intravenous administration in patients with EVD, that need for a concomitant infection this therapy (prescribed by an Infectious Diseases doctor). |
PIVA SIMONE; | 2019-07-02 |
| 92 | Peri-operative Application of EYEPROTX General Anesthesia Protective Goggles As An Effective Modality to Reduce The Incidence of Corneal Injury Post-Intubation Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled trial that seeks to examine the effectiveness of Eyeprotx™ protective goggles in comparison to traditional methods against ocular injury that can occur perioperatively under general anesthesia. |
LEO KLEYMAN; | 2019-06-01 |
| 93 | Randomized Trial of Fast Bacterial Identification and Phenotypic Antimicrobial Susceptibility Testing in Patients With Positive Blood Cultures Using The Accelerate PhenoTest™ BC Kit, Performed on The Accelerate Pheno™ System As Compared With The Verigene® BC-GP/GN PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed as a prospective, randomized, open-label trial evaluating antimicrobial utilization, clinical outcomes, and healthcare costs among patients with positive blood cultures. Patients will be randomized to one of the following FDA-cleared devices that will be used to assess the workflow impact of fast identification (ID) and antimicrobial susceptibility testing (AST) in the microbiology lab and in the quality of care in patients: 1) Standard culture and AST of positive blood culture bottles plus the Verigene® Blood Culture Gram-positive/Gram-negative kit (BC-GP/GN); … |
ACCELERATE DIAGNOSTICS | 2019-05-23 |
| 94 | Does The Use of Topical Otic Drops at The Time of Tympanostomy Tube Placement Improve Outcomes When No Middle Ear Effusion Is Present at The Time of Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine whether the use of topical otic drops intra-operative and post-operative during tympanostomy tube placement reduces the rate of tympanostomy tube occlusion and post-operative otorrhea (ear drainage) during the initial 4-week post-operative period in subjects with no middle ear effusion (fluid behind the ear drum) present at the time of surgery. A within subject controlled study design will be utilized to study this effect. Subjects with absent middle ear effusion who are receiving tympanostomy tube placement will receive a standard protocol of Floxin topical drops during surgery and after surgery in one ear. Selection of ear (right ear or left ear) will be randomized. The primary measured outcome will be the rate of tympanostomy tube occlusion within first 4 weeks postoperatively. The secondary measured outcome is the rate of tympanostomy tube otorrhea (drainage) within first 4 weeks postoperatively. |
KENNETH WHITTEMORE; | 2019-05-16 |
| 95 | Incidence and Outcome of Sepsis in Respiratory Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Sepsis is the most common cause of death in non coronary intensive care units (ICUs). In the past 2 decades, the world has witnessed significant increase in the occurrence rate of sepsis (1). In the ICU, sepsis maybe community acquired (already present on admission) or hospital acquired (obtained during ICU stay). This study will add adequate data about incidence and outcome of sepsis in Respiratory Intensive Care Unit. |
ASHRAF A ELMARAGHY; | 2019-05-01 |
| 96 | Evaluation of The Impact of Ascorbic Acid in The Prevention of Vancomycin Induced Nephrotoxicity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Randomized controlled trial aiming to investigate whether ascorbic acid has a role in preventing vancomycin induced nephrotoxicity or not in critically ill patients. |
NOURAN HESHAM ALI; | 2019-01-17 |
| 97 | Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination By Healthcare-Associated Pathogens PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Extended-spectrum beta-lactamase producing Enterobacteriaceae (EPE), vancomycin-resistant enterococci (VRE) and Clostridium difficile have become a major threat to hospitalised patients worldwide. We hypothesize that receiving inappropriate antibacterial treatment places patients at high risk of intestinal domination and subsequent infection by these bacteria. Further analyses will address cost-effectiveness of specific interventions, behavioural analyses of the decision process leading to inappropriate antibacterial treatment, and the rate of undetected colonization with EPE/VRE/C. difficile on admission. |
MED. JÖRG JANNE VEHRESCHILD; | 2019-01-01 |
| 98 | Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Treatment of Uncomplicated Skin and Soft Tissue Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare how well two different antibiotics, doxycycline (DOXY) and trimethoprim/sulfamethoxazole (TMP/SMX), work at curing uncomplicated skin and soft tissue infection (uSSTI) such as 1.Boils (pus in the skin, also known as abscesses and furuncles) or 2. Infections that appear only on the skin surface (called cellulitis and erysipelas) that have pus. |
LOREN G MILLER; | 2018-11-26 |
| 99 | Preoperative Application of Low-level Microcurrent Dressing (Jumpstart) for Decolonization of P. Acnes Before Shoulder Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to evaluate the efficacy of preoperative treatment with a novel, wireless, low-level microcurrent-generating antimicrobial device (brand name: JumpStart) in preventing the spread of Propionibacterium acnes in patients receiving open or arthroscopic shoulder surgery. |
H MIKE KIM; | 2018-11-01 |
| 100 | Anti-Microbial Effect of Titanium Dioxide Nano Particles Incorporated Acrylic Resin Denture Base Materials in Completely Edentulous Patients: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Although cleaning dentures by immersion in chemical denture cleaning solutions is effective in reducing the number of bacteria, a large number remains adhering to the denture surface. Thus, the mechanical cleansing of dentures is imperative to remove adherent microbes, and prevent diseases. This is not always easy to achieve, due to un-compliant patients, or patients with diminished manual dexterity (e.g. Mani phalanx dysfunction or Rheumatoid Arthritis) that often require assistance in cleaning their dentures, which may not always be available. Therefore, the modification of denture base materials to provide them with antibacterial properties to control oral biofilm formation, … |
MONA MOHAMED IBRAHIM BADRAN; | 2018-10-15 |
| 101 | Longitudinal Changes in Intestinal Microbiota and Its Association With Acquisition of Antimicrobial Resistance in A Cohort of Stroke Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Antimicrobial resistance is regarded as one of the major global public health threats, causing at least 700,000 deaths per year. It has been estimated that if the current problem of antimicrobial resistance is not effectively tackled, it would cause the death of 10 million people worldwide by 2050. Multi-drug resistant pathogen is the single most important contributing factor for inappropriate antibiotics therapy, and this in turn lead to higher mortality in patients with sepsis. The slow pace of development of new classes of antimicrobial agents limits the availability of effective therapy for multi-drug resistant organisms, … |
GRACE LUI; | 2018-08-06 |
| 102 | Investigation Into The Infectivity Levels of Human Papilloma Virus (HPV) in Tonsillar Tissue PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human Papilloma Virus (HPV) has been shown to be a cause of Head & Neck Squamous Cell Carcinoma (HNSCC) and the majority of current studies focus on what is happening in patients with a HPV HNSCC. But there is limited investigation into HPV infection in the oropharynx of patients who do not have HNSCC. The current incidence of oral HPV infection is not known in the general population locally and there is also limited information on what particular localities within the mouth that patients’ harbour HPV infection what strains are present and if there are any differences in viral load. Therefore the aim of this project is to investigate within patients that undergo tonsillectomies the rate of HPV infection in tonsils to determine the amount of HPV present within the community. |
RAGUWINDER SAHOTA; | 2018-07-01 |
| 103 | Use of Disposable Stethoscope Covers for Reduction of Stethoscope MRSA Contamination Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective pilot study using a randomized, controlled, single blinded, crossover trial design, evaluating the effect of daily antimicrobial stethoscope diaphragm covers versus uncovered stethoscope. Stethoscopes will be cleaned Sani-cloth germicidal disposable wipes which are effective against MRSA. Each participant will then be randomly assigned to 7 days in either the intervention or the control arm. At the end of the 7 days participants stethoscopes will be cleaned again. This will be followed by another 7 days in the arm that they are not in during the first 7 days. The primary endpoint is MRSA colony count from stethoscope diaphragms cultures at 7 days, focusing on the difference between the intervention and the control periods. The secondary endpoint is the rate of hospital acquired MRSA infection in patients treated by residents during each period. |
MARWA MOUSSA; | 2018-06-08 |
| 104 | The Effect of Bathing With Chlorhexidine on MRSA and VRE Colonization in Hematology and Oncology Inpatients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hospital-acquired infections (HIs) are defined as an infection developed within 48-72 hours of admission to hospital in whom the infection was not incubating at the time of admission to the hospital or an infection acquired in the hospital but appearing 10 days after discharged. Hospital infections threaten patient safety due to the complications they cause, even if they are preventable problems. Staphylococcus aureus and enterococci which cause hospital infections are among the important pathogens in terms of antibiotic resistance development (MRSA: Methicillin-resistant Staphylococcus aureus, … |
GUL HATICE TARAKCIOGLU CELIK; | 2018-06-01 |
| 105 | Risk-factors for Multidrug-resistant (MDR) and Extensively Drug-resistant (XDR) Bacteria Colonization Among Patients at High Risk of STIs PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to identify risk factors and prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria colonization among patients at high risk of STIs |
LAURE SURGERS; | 2018-05-11 |
| 106 | Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients: Randomized and Controlled Multicenter Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, controlled multicenter clinical trial. The purpose of this study is to compare the continuous infusion of vancomycin with intermittent infusion regarding the effectiveness to reach the target serum level and the relationship between infusion type and nephrotoxicity in critically ill patients. |
JULIANO P ALMEIDA; | 2018-04-28 |
| 107 | The Effect of Polyvalent Mechanical Bacterial Lysate on The Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study assesses the effectiveness of Polyvalent Mechanical Bacterial Lysate (PMBL-Ismigen) in reducing nasal methicillin-resistant Staphylococcus aureus (MRSA) colony growth in children with pollen allergic rhinitis (AR) aged 5 to 17. Half of the participants received PMBL and the other half received a placebo. |
KAMIL JANECZEK; | 2018-04-22 |
| 108 | STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the micro-biologic efficacy and safety of a streamlined treatment for early onset methicillin-resistant staphylococcus aureus (MRSA) in patients with cystic fibrosis. |
MARIANNE MUHLEBACH; | 2018-04-03 |
| 109 | Improving Preoperative Screening and Postoperative Nutrition in Trauma Patients: Does It Decrease Muscle Wasting or Complications PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the proposed study is twofold: 1) The investigators will evaluate ultrasound imaging to screen trauma patients to identify patients at increased risk of postoperative complications associated with sarcopenia. 2) The investigators will evaluate a commercially-available oral nutritional supplement that has previously been evaluated in critically-ill intensive care patients and shown benefit for decreasing complications including decreased wound healing complications, decreased pressure ulcers, decreased skeletal muscle loss due to immobilization, and decreased one-year mortality. |
MICHAEL C WILLEY; | 2018-04-01 |
| 110 | Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis: A Prospective Randomized Placebo-controlled Double-blind Multicenter Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Antimicrobial treatment could be beneficial in patients with ventilator-associated tracheobronchitis (VAT). The hypothesis of this study is that antibiotic treatment for VAT (3 or 7 days), compared with no antibiotic treatment, would reduce the incidence of transition from VAT to ventilator-associated pneumonia (VAP). |
SAAD NSEIR; | 2018-02-08 |
| 111 | Vancomycin De-escalation Therapy in Patients With Pneumonia and Negative MRSA Nasal Swab PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a non-inferiority study evaluating clinical improvement rate when using MRSA nasal swabs to guide discontinuation of vancomycin for empiric coverage for MRSA pneumonia. |
RAYAN IHLE; | 2018-02-08 |
| 112 | Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Because of its prolonged terminal half-life, dalbavancin is an extremely attractive option in treating Gram-positive infections caused by S. aureus including MRSA, and streptococcal species. Systemic bacterial infections due to Staphylococci such as osteomyelitis and septic arthritis, are conditions which require prolonged IV therapy, typically for at least 3-6 weeks, though sometimes more. Due to dalbavancin’s prolonged terminal half-life, it may offer the opportunity to substantially reduce costs and morbidity in native joint and prosthetic joint infections with one infusion every fourteen days until completion of therapy. |
DONALD PORETZ; | 2018-01-25 |
| 113 | Use of Aaerosol Combined With Intravenous Antibiotics for The Treatment of Multidrug Resistant GNB Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate use of aerosol combined with intravenous antibiotics for the treat of multi-drug resistance gram negative bacterias diagnosed ventilator-associated pneumonia in intensive care unit in a hospital. |
SHENG WANG MD PHD; | 2018-01-01 |
| 114 | A Randomized, Double-Blind, Placebo-Controlled Trial of The Efficacy of Retapamulin As A Topical Decolonizing Agent for Mupirocin Resistant Methicillin Resistant Staphylococcus Aureus (MRSA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the efficacy of retapamulin to reduce carriage of MRSA via a randomized, double-blind, placebo-controlled clinical study testing retapamulin among patients with confirmed mupirocin-resistant nasal and/or rectal MRSA colonization. The sample size will include 27 subjects in each of the two arms of the study (retapamulin versus placebo) for a total of 54 subjects. Participants who are found to be nasal and/or rectal colonized with MRSA will be randomized to receive either retapamulin or placebo applied nasally and rectally for a total of 5 days. Nasal and rectal swabs will be collected at pre-defined time points during study duration (screening swab, swab one week after completion of topical therapy, swab 4 weeks after completion of topical therapy) to assess MRSA colonization status. The colonization rates of both groups will be assessed via Fisher’s Exact Test. |
JENNIFER LIGHTER; | 2017-12-01 |
| 115 | Lipidome and Microbiome Profile of The Eye in Rosacea PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The question that the investigators aim to address in this proposal is how the local lipid mediator profiles of ceramides and eicosanoids are altered in cutaneous and ocular rosacea and how antibiotics alter the lipidome. The investigators also seek to understand how the microbiome is changed in those with and without rosacea, and how the microbiome is altered in those with rosacea. Understanding how the lipidome is modulated in rosacea with antibiotic treatment will serve as the first step in targeting therapies toward directly altering the lipidome to reduce inflammation and ultimately reduce the use of antibiotics. |
RAJA SIVAMANI; | 2017-11-02 |
| 116 | Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia (RAPIDS-GN) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: RAPIDS-GN is a multi-center, prospective, randomized, controlled trial to evaluate the following strategies for patients with confirmed gram-negative bacillus bacteremia (GNB): 1. Standard culture and antimicrobial susceptibility testing (AST); or 2. Rapid identification and AST using the Accelerate PhenoTest™ BC Kit, performed on the Accelerate Pheno™ System (AXDX) |
DUKE UNIVERSITY | 2017-10-09 |
| 117 | A Phase III, Randomized, Double-blind, Placebo-controlled Study of AeroVanc for The Treatment of Persistent Methicillin-resistant Staphylococcus Aureus Lung Infection in Cystic Fibrosis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized phase III study to evaluate the clinical effectiveness of AeroVanc in persistent methicillin-resistant Staphylococcus aureus (MRSA) infection in patients with cystic fibrosis (CF). |
PATRICK FLUME; | 2017-09-20 |
| 118 | Comparison of Standard Isolation With Targeted Isolation for Preventing Nosocomial Transmission of MRSA and VRE: A Pilot Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Hospital-acquired infections are common and frequently lead to poor outcomes, including death, in affected patients. Two common organisms that cause infections in the hospital are methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). One strategy used to prevent these infections is contact isolation of hospitalized patients with MRSA and/or VRE. It is unclear whether contact isolation decreases the rate of infection with MRSA and/or VRE. The CONTACT-PILOT study is designed to test the hypothesis that contact isolation decreases the rate of infection with MRSA and/or VRE in patients in the intensive care unit (ICU). The study will enroll all adults in the Medical ICU and will run between September 2017 and April 2018. During some months, all patients in the Medical ICU patients will be placed in isolation for MRSA or VRE if they have a current infection or colonization with either organism, or a recent history thereof. During other months, patients will only be placed in isolation for MRSA or VRE if they have an active, highly-transmissible infection with either organism, such as a pneumonia or an open, draining wound. |
TODD RICE; | 2017-09-01 |
| 119 | Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label, single center, prospective study of patients with a diagnosis of cystic fibrosis (CF) and a history of methicillin-resistant Staphylococcus aureus (MRSA), also known as oxacillin-resistant Staphylococcus aureus (ORSA), … |
ALEXANDER VINKS; | 2017-09-01 |
| 120 | Burst Abdomen in Emergency Midline Laparotomy: Incidence and Risk PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study was conducted in 250 patients who underwent midline Laparotomy at Kasr Al-Ainy emergency department, Cairo University from August 2017 until March 2018. Factors such as age ,sex, body mass index, substance abuse, previous laparotomy, malignancy, diabetes mellitus , ascites, albumin, renal functions, bilirubin, hemoglobin, intra-abdominal pathology, suture material, creation of stoma, post-operative chest infection, , post-operative paralytic ileus, leakage and wound infection were observed and analyzed with odds ratio and P value |
AHMED MAGED; | 2017-08-05 |
| 121 | The Efficacy of Topical Povidone – Iodine Rinses in The Management of Biofilm-associated Chronic Rhinosinusitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Povidone Iodine solution is a nasal antiseptic. Its application has been shown to be clinically safe, tolerable and effective against bacteria and fungi associated with chronic rhinosinusitis. This study will evaluate the effectiveness of Povidone Iodine in this hard-to-treat patient group. Furthermore, the study will also further evaluate any side effects that may occur with the use of Povidone Iodine. |
AMIN JAVER; | 2017-07-28 |
| 122 | Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated Infection PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective is to conduct a prospective, sham controlled, double-blinded, interventional crossover trial to compare standard terminal cleaning plus PX-UV (intervention) with standard terminal cleaning plus sham PX-UV (control) with crossover at 12 months, following a 6-month washout period. Outcome measures include the rates of HAIs, … |
KEITH KAYE; | 2017-07-07 |
| 123 | A Multi-level Antimicrobial Surface Coating for A Healthier Environment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aimed to study the use of the multi-level antimicrobial coating in a working hospital environment. Patient privacy curtains from a public sector hospital were coated and installed in rehabilitation ward in comparison of normally washed curtains in the same setting and compared the mean reduction on both control and treatment end to assess the effectiveness of coating against hospital acquired infections including multidrug resistant organisms (MDROs). |
KING LUN YEUNG; | 2017-06-01 |
| 124 | Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) – Point-of-care-testing (POCT) in Clinical Decision Making PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study EPICS-6 consists of three study phases. Emergency Department patients are screened for nasal and pharyngeal colonisation with Methicillin sensitive and Methicillin resistant Staphylococcus aureus (MSSA/MRSA) using a point-of-care (POC)-PCR-testing method (cobas®LIAT®-System, Roche Molecular Systems Inc.) The first aim of this study is to describe the prevalence of MSSA/MRSA-colonisation in a routine cohort of Emergency Department patients. The second aim is to determine the impact of POC-guided decolonisation as compared to conventional laboratory testing on in-hospital infection rates with MSSA/MRSA in a pre-post-comparison study. |
MARTIN MOECKEL; | 2017-05-01 |
| 125 | Cluster-randomized Non-inferiority Trial Comparing Mupirocin Vs Iodophor for Nasal Decolonization of ICU Patients to Assess Impact on S. Aureus Clinical Cultures and All-cause Bloodstream Infection During Routine Chlorhexidine Bathing PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the non-inferiority of two decolonization regimens: Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that enrolled subjects represents 137 individual HCA Hospitals (representing ~235 ICUs) that have been randomized. |
RICHARD PLATT; | 2017-05-01 |
| 126 | Randomized Clinical Trial to Assess Whether The Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL By Antiretroviral Treatment Influences The Rate of Carriage of Multidrug-resistant Bacteria PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis pneumonia and other infections in HIV positive patients with low immunity. Common clinical practice is to start CPT in any patient with CD4 counts below 200/µL, and, conversely, to stop CPT when immunity has been restored by antiretroviral treatment to CD4 counts above 200/µL or when viral suppression has been documented for 3 months. However, the latest WHO guidelines widely expands the indication for CPT by advocating for settings with high prevalence of malaria and bacterial infections, … |
JOEL MANYAHI; | 2017-03-30 |
| 127 | Derma-Stent Novel Abscess Packing Device (Pilot Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this research study, a device called the Derma-Stent will be tested. The sponsor of the study, Mar-Med Company, will supply the device. This device is used to drain a cutaneous abscess, which is a skin infection that results in buildup of pus under the skin. Currently, the normal treatment for this abscess is to cut and drain and the wound, and later pack the wound with gauze. Packing is done to prevent the pus to accumulate again. But regular gauze is difficult for patient to remove themselves, … |
AARON BRODY; | 2017-03-27 |
| 128 | Randomized Study Comparing Different Durations of Antibiotic Treatment for Diabetic Foot Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, unblinded, single-centre study. After eventual surgical debridement (not amputation), patients will be randomized to receive 1 of 2 targeted antibiotic regimens, in the ratio 1:1. For diabetic toe osteomyelitis, the patients will be randomized between a 3 and a 6 week’s arm, for soft tissue infections between 10 and 20 days. The final assessments used in the primary efficacy analysis will be obtained at the test-of-cure (TOC) visit approximately 60 days after treatment is stopped. |
ILKER UCKAY; | 2017-02-16 |
| 129 | Tolerability, Safety, and Efficacy of Tedizolid As Oral Treatment for Bone and Joint Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The problem of interest is that doctors are looking for new antibiotic treatments for bone and joint infections. Treatment for bone and joint infection is not standardized, which allows a wide range of antibiotic therapy to potentially be given. A type of bacteria called S. aureus is the most common cause of bone and joint infection. Methicillin resistant S. aureus (MRSA) is a type of bacteria that is not killed by some antibiotics, and it is increasingly common in U.S. and non-U.S. medical centers. This problem will be studied by investigating whether an antibiotic called tedizolid is tolerable, … |
LOREN G MILLER; | 2017-02-06 |
| 130 | Community-associated Staphylococcus Aureus Infections in China: Epidemiology, Molecular Characteristics, Treatment, and Outcome PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), strains of MRSA that are able to infect otherwise healthy people outside of hospital settings, emerged in the late 1990s and have recently arisen in many countries around the globe. CA-MRSA strains are usually distinguished from their HA-MRSA counterparts by the following characteristics: Firstly, CA-MRSA strains are usually susceptible to non-lactam antibiotics. Secondly, CA-MRSA harbors type IV and V SCCmec elements, which are shorter than the traditional type I, II, and III SCCmec elements found in HA-MRSA strains. Thirdly, … |
JIAN-CANG ZHOU M.D.; | 2016-12-15 |
| 131 | A Phase 3, Multicenter, Randomized, Double-Blind, Comparator-Controlled Study to Evaluate The Safety and Efficacy of Intravenous to Oral Delafloxacin in Adult Subjects With Community-Acquired Bacterial Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and efficacy of delafloxacin compared to moxifloxacin in the treatment of adult patients with community-acquired pneumonia. |
MELINTA THERAPEUTICS | 2016-12-14 |
| 132 | A Prospective, Single Center, Randomized, Double-blind, Placebo Controlled Study in Two Phases to Evaluate The Safety and Efficacy of ATx201 As A Topical Antibiotic Agent PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: AntibioTx is developping ATx201 as a topical product for treatment of skin infections, including infected atopic dermatitis. |
MARKUS ZEITLINGER; | 2016-12-01 |
| 133 | The First in The World Human Proof-of-concept Study on Disinfection and Healing Acceleration Capabilities of 222nm Wave Length Narrow Band Ultraviolet Lighting Device PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The threat of MRSA and multi-drug resistant pathogens have been growing in recent years. A new means of countering the infectious threat is required and one such modality is the use of UV light for disinfection. The aim of the study is to proof the efficacy of the 222nm UV light in disinfection on patients with sacral sores. This is a first in human proof-of-concept study |
NATIONAL UNIVERSITY HOSPITAL SINGAPORE | 2016-12-01 |
| 134 | Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery: A Double Blinded Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. With the increasing rate of identified P. acnes shoulder surgery infection despite the use of recommended skin preparation and preoperative prophylactic antibiotics, a question arises; Is Cefazolin the most effective prophylactic antibiotic for shoulder surgery? The objective of this study is to determine if Ceftriaxone is superior to Cefazolin as a prophylactic antibiotic for skin colonization with P. acnes in primary shoulder surgery |
DOMINIQUE ROULEAU; | 2016-12-01 |
| 135 | Evaluation of The Effect of Platelet Rich Plasma (PRP) on The Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair By Modified Millard Cheiloplasty: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate effect of platelet rich plasma on scar formation of unilateral cleft lip repair. |
SHAIMAA MOHSEN; | 2016-12-01 |
| 136 | Investigation of The Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Linezolid is the second line agent in the treatment of MRSA and PRSP infections, and it is also the drug of choice for VRE infections. It can be an alternative option against multidrug resistant tuberculosis and non-tuberculosis mycobacterium. However, Patients who receive more than 2 weeks of treatment duration and who have renal dysfunction or severe cirrhosis may prone to experience anemia, thrombocytopenia, and leukopenia. Long-term use may also result in lactic acidosis, peripheral neuropathy and optic neuropathy due to mitochondrial toxicity. Thus, … |
SHU-WEN LIN; | 2016-11-01 |
| 137 | The Use of Clinell Universal Wipes, Clinell Sporicidal Wipes, and Clinell EvaluClean Fluorescent Marker System, in Reducing Environmental Contamination and Acquisitions of Multidrug Resistant Organisms and Hospital Acquired Infections PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Multidrug resistant organisms (MDRO) are prevalent in hospitals and are associated with hospital-acquired infections (HAI). High-touch surfaces serve as reservoirs and fomites for MDRO transmission. The investigators quantified the impact of hanging single-use cleaning/disinfecting wipes in patients’ immediate environment within multi-patient rooms. Pre-specified outcomes were: 1) HAI rate, 2) cleaning frequency, 3) MDRO room contamination, 4) new MDRO acquisitions, and 5) in-hospital mortality. |
DROR MARCHAIM; | 2016-10-20 |
| 138 | Randomized Controlled Trial of Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in A Neonatal Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether or not mupirocin treatment results in S. aureus decolonization in affected NICU patients. |
MELISSA NELSON; | 2016-10-01 |
| 139 | A Comparative Efficacy Study of Vancomycin Dosage Adjustment By Equation-based Method and Vancomycin Trough Concentration Method for Treatment of Infections Caused By Methicillin Resistant Staphylococcus Aureus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: An open-label randomized controlled trial to compare two vancomycin dosage adjustment methods |
PINYO RATTANAUMPAWAN; | 2016-10-01 |
| 140 | Therapeutic Monitoring of Vancomycin in Critical Ill Patients: A Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Vancomycin is a glycopeptide antibiotic that is the first line antibiotics for the treatment of serious gram-positive infections involving methicillin-resistant Staphylococcus aureus (MRSA). Its therapeutic window is narrow, so there is a need to monitor serum vancomycin concentration in clinical practice, especially in the critically ill patients. So far, few studies have investigated the clinical outcomes of the dosage strategy that vancomycin dosage is administered and adjusted individually using PPK and Bayesian methods based on observed concentrations. The objective of this study is to investigate the effectiveness, safety and economics of the vancomycin individualized dosing service provided by pharmacists. |
QINGGANG GE; | 2016-10-01 |
| 141 | Evaluation of The Effectiveness of Chlorhexidine Bathing in Reducing Nosocomial Infections in The Neonatal Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, controlled; crossover study of daily bathing with no-rinse, 2% chlorhexidine gluconate (CHG) impregnated washcloths versus bathing with water/soap or water according to gestational age and weight (e.g. standard bathing). The trial will take place in the Neonatal intensive care unit (NICU). Baseline data ragarding bloodstream infections (BSI) and colonization with multidrug resistant orgnisms (MDRO) will be collected for 3-6 months prior to patient enrollment. In the preliminary phase of the study we will establish the safety of chlorhexidine bathing using Clinell ® Chlorhexidine wash cloths on three groups of patients: term infants admitted to the NICU; … |
MASKIT BAR-MEIR; | 2016-09-01 |
| 142 | A Phase 3, Randomized, Double-Blind, Double-Dummy Study to Compare The Efficacy and Safety of Oral Lefamulin (BC 3781) Versus Oral Moxifloxacin in Adults With Community-Acquired Bacterial Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the safety and efficacy of lefamulin, a pleuromutilin, for the treatment of adults with moderate community-acquired bacterial pneumonia |
NABRIVA THERAPEUTICS AG | 2016-08-01 |
| 143 | Impact of Daily Bathing With Chlorhexidine in The Critical Patient: Colonization and Environment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The search for preventive measure with daily bathing with chlorhexidine in the critical care patient will result in a reduction in patient colonization with multidrug resistant pathogens. Thus, preventing healthcare associated infections. The aim of this study was to determine the impact of daily bathing with chlorhexidine in patient colonization, environment and healthcare workers in the medical intensive care unit (MICU). The study will be conducted at the University Hospital Dr. José Eleuterio González, a 450-bed teaching hospital in Monterrey, northeast Mexico. This is a prospective, experimental, randomized, open-label, … |
MICHEL FERNANDO MARTINEZ-RESENDEZ; | 2016-08-01 |
| 144 | Admission Toxigenic C. Difficile Surveillance to Reduce Hospital Onset C. Difficile Infection (CDI) PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Clostridioides (formerly Clostridium) difficile Infection (CDI) is a persistent healthcare issue. In the US, CDI is the most common infectious cause of hospital-onset (HO) diarrhea. Objective: Assess the impact of admission testing for toxigenic C. difficile colonization on the incidence of clinical disease. Design: Pragmatic stepped-wedge Infection Control initiative. Setting: NorthShore University HealthSystem (NorthShore) is a four-hospital system near Chicago, … |
NORTHSHORE UNIVERSITY HEALTHSYSTEM | 2016-07-01 |
| 145 | Staphylococcus Aureus Resistant to Methicillin (MRSA) Screening in Trauma Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study and to know the incidence of healthy carriers of Staphylococcus aureus resistant méti- patients supported for fracture of the proximal femur . This assessment will be made preoperatively by a nasal sampling and analysis through it by rapid Polymerase Chain Reaction method GeneXpert® . |
NICOLAS REINA; | 2016-06-04 |
| 146 | Does UROSHIELD® Influence Bacterial Growth On Endotracheal Tubes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the effect of UROSHIELD® (a device which generates low energy ultrasound waves) on development of bacterial colonies on endotracheal tubes, in patient receiving mechanical ventilation, and to determine whether this device lowers the rate of bacterial resistance to antibiotics. |
REUVEN FRIEDMANN; | 2016-04-01 |
| 147 | Safety and Tolerability Study of Antimicrobial TheraGauze for Skin Abscess Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to demonstrate safety and tolerability of a novel antimicrobial wound dressing, Antimicrobial TheraGauze. The unique microvillous structure of TheraGauze is ideal for the development of an antimicrobial wound dressing. In vitro testing has demonstrated that tobramycin is an ideal compound for integration into TheraGauze providing excellent killing of MRSA and other organisms that commonly cause wound infections. Tobramycin is a non-absorbable aminoglycoside that will be contained solely to the wound bed preventing any potential for systemic toxicities. In vivo testing of tobramycin-impregnated TheraGauze used in mouse wound models has confirmed no systemic absorption of tobramycin as demonstrated by undetectable blood levels. TheraGauze has been commercially available for 10 years as a wound dressing. Tobramycin has been available for many years as a topical antibiotic as eyedrops and as an inhaled antibiotic for patients with cystic fibrosis, demonstrating excellent safety in both cases. This Phase I trial will test Antimicrobial TheraGauze (ATG) as an antimicrobial wound packing for patients presenting to an Emergency Department with skin abscess (furunculosis). Subjects will either receive ATG or standard of care wound packing (cotton wick or iodoform wick). Subjects will return to the ED in 2 days for wound packing removal and reassessment of their wounds and symptomatology. A final followup will be performed by a physician and study coordinator in an outpatient setting on day 7. |
KENJI CUNNION; | 2016-04-01 |
| 148 | Swiss PACK-CXL (Photoactivated Chromophore for Infectious Keratitis Cross-linking) Multicenter Trial for The Treatment of Infectious Keratitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the safety and efficacy of PACK-CXL (photoactivated chromophore for infectious keratitis cross-linking) as a firstline treatment for infectious corneal infiltrates and early corneal ulcers, and compare it to the current standard of care, antimicrobial therapy. |
FARHAD HAFEZI; | 2016-03-01 |
| 149 | Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Vancomycin is the standard first-line treatment for MRSA infections and a first-line empiric therapy. The relationship between exposure to vancomycin and efficacy is admitted but because of an important intersubject variability, therapeutic exposure isn’t usually achieved. The primary aim of this randomized controlled trial is to evaluate a new early dosage adjustment strategy of vancomycin in children, comparing it to the usual treatment strategy. Using a bayesian approach, … |
JEAN-MARC TRELUYER; | 2016-02-23 |
| 150 | MRSA Eradication and Decolonization in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators intend to compare therapies (abscess surgery and hygiene education compared to abscess surgery and hygiene education followed by decolonization) for Methicillin-Resistant Staphylococcus Aureus skin and soft tissue infections (MRSA SSTI) to determine which is the more effective treatment. The investigators focus on patient centered outcomes as described by the families of MRSA infected patients. Such outcomes are likely to include quality of life, side effects, … |
PAUL MUSEY; | 2016-02-01 |
| 151 | Comparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA Related Papers Related Patents Related Grants Related Experts View Highlight: To determine if routinely available 10% povidone-iodine swabs are more effective than saline and 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP for decolonizing MRSA. |
ROTHMAN INSTITUTE ORTHOPAEDICS | 2016-01-06 |
| 152 | An Innovative Approach to Understanding and Controlling Transmission of HAIs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the impact of copper linens on hospital acquired infections and drug resistant bacteria. |
EBBING LAUTENBACH; | 2016-01-01 |
| 153 | Rapid Diagnostic Testing to Guide Antibiotic Therapy in Drug Resistant Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to conduct a randomized clinical trial to compare an antibiotic strategy based on a novel diagnostic test, polymerase chain reaction (PCR) to usual care, in critically ill adults with pneumonia suspected to be caused by methicillin resistant staphylococcus aureus (MRSA). The investigators hypothesize that when automated PCR is used to guide antibiotic therapy, antibiotic exposure will be reduced in critically ill subjects with pneumonia. |
RICHARD WUNDERINK; | 2016-01-01 |
| 154 | Ultra Violet-C Light Evaluation As An Adjunct to Removing Multi-Drug Resistant Organisms (UVCLEAR-MDRO) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines the impact of UV-C light disinfection as an adjunct to routine daily and discharge patient room cleaning on patient infection and colonization with hospital associated bacteria. Patient rooms are counted as enrolled since consent was waived and the number of participants is unknown. Total of 83 rooms. |
LISA MARAGAKIS; | 2015-12-01 |
| 155 | Randomized, Double Blind, Placebo-controlled Study of The Safety, Tolerability and Pharmacokinetics After Single Ascending Doses or Multiple Ascending Doses of OSCN-, BLF or ALX-009 in Healthy Male and CF and Non-CF Bronchiectasis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability and pharmacokinetics of a single ascending doses (SAD) and multiple ascending doses (MAD) of Hypothiocyanite (OSCN-), bovine lactoferrin (bLF) and their combination (ALX-009) in healthy male volunteers and patients suffering from cystic fibrosis (CF) and non-CF bronchiectasis (NCFBE). |
ISABELLE DURIEU; | 2015-11-01 |
| 156 | A Multi-center Prospective Randomized Open Label Study of Utilizing Interleukin 10 (IL-10) Levels As A Guide for Antibiotic Selection for Methicillin Resistant Staphylococcus Aureus Bacteremia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with MRSaB have high therapeutic failure rates and mortality rates. Recent studies have shown that an elevated IL-10 level is an independent risk factor of mortality. It may also serve as biomarker for very early risk stratification. The aim of this study is to compare the outcomes for patients with elevated IL-10 levels (≥8 pg/ml) when treated with standard antibiotic therapy (daptomycin or vancomycin) versus early aggressive therapy (daptomycin with ceftaroline) for the treatment of MRSaB. |
MATTHEW GERIAK; | 2015-11-01 |
| 157 | Integrating Personal and Household Environmental Hygiene Measures to Prevent Methicillin-Resistant Staphylococcus Aureus Infection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators propose a pragmatic comparative effectiveness trial evaluating several decolonization strategies in patients with Staphylococcus aureus infection, their household contacts, and household environmental surfaces. The central hypothesis of this proposal is that an integrated approach of periodic personal and household environmental hygiene will reduce S. aureus transmission in households and subsequently decrease the incidence of skin and soft tissue infections (SSTI). |
STEPHANIE A. FRITZ; | 2015-10-01 |
| 158 | Prophylactic Negative Pressure Wound Therapy in Obese Women After Cesarean: A Pilot Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Surgical site infections (SSIs) complicate 5 – 12% of cesareans. Negative pressure wound therapy (NPWT) – a closed, sealed system that applies negative pressure to the wound surface – has been used to treat open wounds since the late 1990s. Experimental evidence suggests NPWT promotes wound healing by removing exudate, approximating the wound edges, and reducing bacterial contamination. Although effectiveness of prophylactic NPWT is biologically plausible and non-randomized studies suggest benefit in reducing SSIs, … |
METHODIUS G TUULI; | 2015-10-01 |
| 159 | Patient-Centered Comparative Effectiveness Research (CER) Study of Home-based Interventions to Prevent CA-MRSA Infection Recurrence PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of the project is to develop and evaluate a home-based intervention to prevent re-infection and transmission of Community-Acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA) in patients presenting to primary care with skin or soft tissue infections (SSTIs). Centers for Disease Control (CDC) CA-MRSA guidelines include incision and drainage, antibiotic sensitivity testing and antibiogram-directed prescribing. Re-infections are common, ranging from 16% to 43%, and present significant challenges to clinicians, … |
JONATHAN N TOBIN; | 2015-10-01 |
| 160 | Decolonization of The Oropharynx, An Important and Neglected Reservoir of S. Aureus Colonization PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The problem of interest is the high rate of recurrent SSTIs in children caused by S. aureus despite the use of systemic antibiotic treatment, due to difficulties in decolonization and the prevalence of antibiotic-resistant strains such as MRSA. This problem will be studied through a randomized, double-blind, placebo-controlled clinical trial of the use of a 0.12% clorhexidine gluconate (CHG) oral rinse in decolonizing S. aureus in the oropharynx in children 5-17 years old. CHG is an excellent candidate for use in children as its safety has been widely established, and it is readily commercially available. Eligible, … |
LOREN G MILLER; | 2015-10-01 |
| 161 | A Phase 3, Randomized, Double-Blind, Double-Dummy Study to Compare The Efficacy and Safety of Lefamulin (BC 3781) Versus Moxifloxacin (With or Without Adjunctive Linezolid) in Adults With Community-Acquired Bacterial Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the safety and efficacy of lefamulin, a pleuromutilin, for the treatment of adults with moderate to severe community-acquired bacterial pneumonia. |
NABRIVA THERAPEUTICS AG | 2015-09-01 |
| 162 | Besifloxacin Ophthalmic Suspension in Patients With Bacterial Keratitis: A Prospective, Randomized Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study comparing a new treatment for bacterial keratitis (also known as corneal ulcers) with the current standard of care. It is a randomized trial, and the investigators plan to test whether besifloxacin (a new antibiotic) in comparison to the current standard of treatment, fortified antibiotic drops (cefazolin and tobramycin). |
JEAN DESCHENES; | 2015-09-01 |
| 163 | Prevention of Healthcare Associated Infections in Bone Marrow Transplant Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study involves sampling bone marrow transplant patients, hospital workers and the patient room for microbes using swabs and other techniques. We send these samples to the laboratory, where they will use state-of-the art technology to identify and relate the microbes to each other. This study also involves putting copper, nickel, or titanium into some hospital rooms, and seeing whether these metals influences the growth of microbes. Some equipment in the hospital room, such as faucets and soap dispensers will be replaced by sensor-based (e.g. touchless) controls. |
LINDA HOANG; | 2015-09-01 |
| 164 | CAMERA 2 – Combination Antibiotic Therapy for Methicillin Resistant Staphylococcus Aureus Infection – An Investigator-initiated, Multi-centre, Parallel Group, Open Labelled Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to determine whether a novel combination antibiotic treatment (vancomycin/daptomycin + beta-lactam) is superior to the standard antibiotic treatment (vancomycin/daptomycin) for hospitalised adults with Methicillin Resistant Staphylococcus aureus bacteraemia. The hypothesis is that the addition of beta-lactam antibiotics (these are antibiotics from the penicillin family) to the standard therapy will lead to more efficient bacterial killing and hence lead to faster clearance of bacteria from the blood stream and other areas of infection, thereby reducing the risk of the spread of infection and death. The study design is an investigator-initiated, multi-centre, open-label, … |
JOSHUA DAVIS; | 2015-08-26 |
| 165 | Molecular Epidemiology and Phylodynamic and Phylogeographic Analysis of Community-associated Methicillin-resistant Staphylococcus Aureus (CA-MRSA) Transmission: An Emergency Department Population Sampling Strategy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Given that the Emergency Department (ED) has become the entry way for large populations of patients into the health care system, a strategy of sampling MRSA isolates in ED populations and merging this information with patient-level data may present a window to hypothesize and investigate CA-MRSA transmission within the community and its impact on hospital-acquired infections. |
JOSEPH A TYNDALL; | 2015-08-01 |
| 166 | Impact of The Introduction in A Heart Surgery ICU of A PCR Technique (Cepheid Xpert® SA Nasal Complete Assay) to Identify Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus in Nasal and Respiratory Tract Samples PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In patients on mechanical ventilation, it is not known whether the identification of S. aureus in LRT samples improves the performance of its nasal detection. To assess the MSSA or MRSA carrier status of patients requiring mechanical ventilation for more than 48 hours after major heart surgery: comparing the performance of the diagnostic technique Xpert® SA Nasal Complete assay in nasal swab and LRT samples. |
EMILIO BOUZA; | 2015-07-01 |
| 167 | Antimicrobial Activity of A Quaternary Ammonium Methacryloxy Silicate-containing Acrylic Resin: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One of the major challenges in orthodontic treatment is long-term stability. Because removable retainers are worn for at least one year, bacteria and fungi may accumulate on the retainers in the form of multi-species plaque biofilms. This may result in increased incidence of proximal dental caries or oral candida infection. Thus, … |
FRANK TAY; | 2015-07-01 |
| 168 | TRI-STAR: Initial and Chronic MRSA Infection in CF (TRanslational Investigation of STaph. Aureus Resistance) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to examine features of MRSA that are associated with chronic MRSA infection and bacterial persistence despite IV antibiotic therapy. Subjects are asked to expectorate sputum and complete CF symptom diaries both at beginning and end of IV therapy. |
MARIANNE S MUHLEBACH; | 2015-07-01 |
| 169 | Steady-State Pharmacokinetics of Tedizolid in Plasma and Sputum of Patients With Cystic Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study is designed to characterize the pharmacokinetics of intravenous and oral tedizolid in patients with Cystic Fibrosis. |
PAUL BERINGER; | 2015-07-01 |
| 170 | Phase 2 Study Evaluating The Kinetic Properties of An Autologous Microbiome Transplant in Adult Atopic Dermatitis Patients Related Papers Related Patents Related Grants Related Experts View Highlight: Unlike healthy control skin, the skin of patients with atopic dermatitis (AD) is frequently colonized by Staphylococcus aureus (S. aureus), putting these patients at increased risk of S. aureus skin infections. In addition, research in the investigator’s lab has shown that these patients have fewer protective Staphylococcal species such as Staphylococcus epidermidis (S. epidermidis) that are known to produce antimicrobial peptides that play a role in protecting the skin from invading pathogens. In this study, … |
RICHARD GALLO; | 2015-07-01 |
| 171 | ANti-infective Stewardship Using The Wisca Tool in The Electronic Medical Record PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Beginning in the mid-to late 1980s and accelerating through the 1990s and 2000s the shield of antibiotic invincibility began to crack sufficiently so that it was apparent to everyone we faced a serious problem. The investigators will demonstrate and expand the use of information technology based on the ingenious weighted-incidence, syndromic, combination antibiogram (WISCA) tool for the widespread use of automated clinician prompts enhancing empiric antibiotic therapy as part of a comprehensive infection control stewardship program that reduces antibiotic resistance. This research program will demonstrate that use of such a tool lowers mortality, improves outcome, … |
LANCE R PETERSON; | 2015-06-15 |
| 172 | Prevalence of S. Aureus Among Patients Presenting With Skin and Soft Tissue Infections: A Multi-centre Pilot Study in Europe PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Methicillin-resistant Staphylococcus aureus (MRSA) is reported as one of the main causative pathogen of community acquired SSTIs. In the USA, high prevalence of MRSA among Skin and soft tissue infections (SSTIs) is known to be due to the spread of the USA300 clone [Moran et al. 2006]. Among S. aureus SSTIs infections in Europe, data regarding the prevalence of MRSA in SSTIs and the causative genotypes remain scarce. The paucity of literature on the prevalence of MSSA, … |
FRANÇOIS VANDENESCH; | 2015-06-01 |
| 173 | Effect of Antibiotics on Community-Associated Staphylococcus Aureus Colonization and Recurrent Infection in Patients With Uncomplicated S. Aureus Skin Abscesses PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Infections due to S. aureus are a major healthcare burden. Currently there is not an effective way to prevent S. aureus infection. Treatment failure can happen in up to 20% of patients with SSTI and mean additional cost per patient can be over $1500. Antibiotics are often prescribed for the treatment of CA-S. aureus SSTI. Current IDSA CA-MRSA guidelines suggest that incision and drainage alone may be adequate for management of uncomplicated CA-S. aureus skin abscesses and there is uncertainty about the need of antibiotics. It is not known whether antibiotics are helpful in decreasing S. aureus colonization rates or preventing future S. aureus infections. Though resolution of acute abscess after drainage may be unchanged by antibiotic administration, the impact of managing S. aureus abscess without antibiotics on ongoing S. aureus colonization and recurrent infection requires further study. This study seeks to examine whether the management of initial S. aureus abscesses with incision and drainage in addition to antibiotic therapy is an effective means of preventing recurrent infection. The prolonged longitudinal follow-up of this study is another unique characteristic that will enable the investigators to capture data about recurrences of infections. |
MARCELA RODRIGUEZ; | 2015-06-01 |
| 174 | DExterous Hand Control Through Fascicular Targeting (DEFT) – (Human Subjects) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our goal is to temporarily implant the following groups for 540 +/- 30 days: 1. Forearm FAST electrodes 1. Five human partial hand amputees (amputated at the level of the hand) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve. 2. Five human hand and forearm amputees (amputated at the level of the forearm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve . 2. Arm FAST electrodes 1. Five human partial hand amputees (amputated at the level of the hand) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve. 2. Five human hand and forearm amputees (amputated at the level of the forearm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve. 3. Five human hand, forearm and arm amputees (amputated at the level of the arm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve. |
JONATHAN CHENG; | 2015-06-01 |
| 175 | A Randomized, Multicenter, Double-Masked, Placebo-Controlled, Phase 3 Study to Evaluate The Safety and Efficacy of Vancomycin Hydrochloride Ophthalmic Ointment 1.1% in Patients With Moderate to Severe Bacterial Conjunctivitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 3 study to evaluate the safety and efficacy of a vancomycin hydrochloride ophthalmic ointment dosed 4 times daily for 7 days compared to placebo (vehicle) in patients with moderate to severed Gram-positive bacterial conjunctivitis. |
KUROBE | 2015-05-01 |
| 176 | Effect of MVX (Titanium Dioxide) on The Microbial Colonization of Surfaces in An Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Environmental cleanliness As antimicrobial resistance is a major and overall deteriorating public health problem international cooperation is necessary. Continued progress is needed to implement and improve programmes for the prevention and control of antimicrobial resistance and HAIs. Environmental cleanliness might be one of the most important initiatives to reduce HAIs. Hospital surfaces are heavily contaminated with bacteria with the highest numbers on surfaces closest to the patients. Bed rails, nurse call buttons, curtains, towel dispensers, door handles, sinks, floors, clinical information stations, medical devices, stethoscopes, staff toilets etc. Actually, … |
DRS. B. DE JONG; | 2015-03-01 |
| 177 | A Retrospective Study of Relationships Between Loading Regimen，Serum Trough Concentrations，Efficacy and Safety in Pneumonia Patients With Gram-positive Infections Treated With Teicoplanin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a retrospective study that all teicoplanin-treated adult patients with Gram-positive infections admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University from February 2015 to August 2016. |
LIJUAN ZHOU; | 2015-02-01 |
| 178 | IDC 56: A Randomized Double-blinded Study Comparing Ceftaroline to Standard of Care Therapy With Cefazolin and Vancomycin As Surgical Prophylaxis for High Risk Orthopedic and Cardiac Surgeries PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a randomized double-blinded study comparing ceftaroline to standard of care therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and cardiac surgeries. Study participants will be enrolled from those undergoing cardiothoracic surgery involving sternotomy and those undergoing prosthetic joint replacement of either hip or knee. Consenting patients will be randomized 2:1 to receive either ceftaroline or cefazolin/vancomycin. This study will be blinded by the use of placebo vancomycin infusions and placebo cephalosporin infusions. The primary end point will be the development of a surgical site infection within 30 days of surgery. |
GEORGE SMULIAN; | 2015-01-01 |
| 179 | A New Method for Detection of Bacteria in The Bloodstream PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim is to determine if this new technique will detect and identify bacteria in the blood sooner than standard blood cultures or identify patients who may be septic without growing bacteria in their cultures. These will be correlated with the data collected from medical records on presumed sepsis. These results will be linked to data concerning infection that will be available as part of routine care including blood counts and other laboratory values that would be part of the routine medical care such as a white blood cell count. The earlier the bacteria are identified and the appropriate antimicrobials are administered the better the patient outcome. |
BRENDA FAHY; | 2015-01-01 |
| 180 | The Pharmacokinetics and Pharmacodynamics of High-dose Daptomycin in Patients With Septic Shock PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The first objective of this study was to characterize the pharmacokinetics and pharmacodynamics of daptomycin with a daily dose of 12mg/kg in septic shock patient; the second objective is to identify the optimal dosing scheme for daptomycin among patients with septic shock and to enhance therapeutic outcomes. |
YINGZI HUANG; | 2015-01-01 |
| 181 | Vitamin D Supplementation to Persistent Carriers of MRSA – A Double Blind, Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to treat persistent MRSA carriers with vitamin D supplementation during a 12 month to see if the number of MRSA positive patients can be reduced. |
PETER BERGMAN; | 2014-12-01 |
| 182 | Human Immunity Against Staphylococcus Aureus Skin Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: – Staphylococcus aureus, or staph, is commonly found on the skin and in the respiratory system. Sometimes people who get sick with staph infection do not get better with standard treatment. These staph infections can be serious and even deadly. Researchers want to find out why some people are more likely to get the infection. Objectives: – To look at the immune response of the skin when it is exposed to bacteria. Eligibility: – People age 2 65 with hyper IgE syndrome (HIES) and those with recurrent staph infections. – Healthy volunteers. Design: – … |
IAN A MYLES; | 2014-10-10 |
| 183 | Topical Vancomycin for The Reduction of Surgical Site Infections in Neurosurgery PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures. Adult patients undergoing neurosurgery at either institution will be eligible for participation in this randomized control trial. Patients randomized to the treatment group will receive 2g of vancomycin applied as a powder or paste to the wound site and/or bone flap. Subjects in the control group will receive the current standard of care without topical vancomycin. All subjects will undergo swabbing of the anterior nares and the surgical site prior to surgery, once 10-14 days following the operation and 90 days following the operation. The primary outcome measure will be surgical site infection, assessed daily throughout the hospital stay, at the first follow-up visit, and by telephone at 14-30 days and 90 days (+/- 7 days). Secondary outcomes will include length of hospital stay, length of intensive care stay, rate of reoperation and patient mortality. In addition, systemic vancomycin levels will be assessed at 6 hours and 20 hours postoperatively in each patient. Patients who have an external ventricular drain in place will have vancomycin levels assessed daily. In patients who have cranial drains placed, vancomycin concentrations will be analyzed from daily in wound drainage. Skin and nasal flora will be analyzed to assess the impact of topical vancomycin on the patient microbiome. Although there has been a decrease in the incidence of infections following craniotomy secondary to prophylactic intravenous antibiotics, proper sterile techniques, and other interventions, SSIs continue to significantly impact morbidity, mortality, and cost burden. Although never studied in neurosurgical procedures other than instrumented spine, the application of topical vancomycin to the surgical site prior to wound closure has demonstrated a reduction in SSIs in spine, cardiac and ophthalmologic procedures. The benefits of using prophylactic vancomycin topically, as opposed to intravenously, include reduced systemic levels of the drug, and therefore, a decreased probability of adverse events related to the drug, such as inducing resistance among the native flora. The investigators propose a single-blinded randomized control trial to evaluate the effectiveness of topical vancomycin in reducing SSIs rates following neurosurgical procedures. |
E. SANDER CONNOLLY; | 2014-10-01 |
| 184 | A Randomized Double-Blind, Placebo-Controlled, Crossover to Open Label, Phase 2 Study of Aerosolized Amikacin and Fosfomycin Delivered Via The Investigational EFlow® AFIS Inline System in Mechanically Ventilated Patients With Gram-negative And/or Gram-positive Bacterial Colonization Related Papers Related Patents Related Grants Related Experts View Highlight: To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin Fosfomycin Inhalation System (AFIS) versus aerosolized placebo in mechanically ventilated patients with Gram-negative and / or Gram-positive bacterial colonization. |
CARDEAS PHARMA | 2014-10-01 |
| 185 | A Randomized Comparison Study of Minimally Invasive Loop Drainage Versus Standard Incision and Drainage for Skin Abscesses in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare abscess drainage utilizing the vessel loop technique in children to the standard incision and drainage technique with the endpoint to determine if rates of treatment failure are non-inferior. |
LOGAN R RENCHER; | 2014-09-01 |
| 186 | Effectiveness of Screening and Decolonization of S. Aureus in Surgery Outpatients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphylococcus aureus (SA) healthcare-associated infections (HAI) cause significant morbidity and mortality. SA causes 15% of all HAI and 30% of surgical site infections (SSIs). Each year over 40 million Americans undergo operations, 1-10% of whom will acquire SSIs. Such infections double the length of hospitalization and risk of dying, … |
SUSAN E KLINE; | 2014-07-01 |
| 187 | Comparison Between Two Different Antibiotic Regimens for The Placement of Dental Implants: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In order to prevent infections and complications, it has been initially established with the dental implant placement protocol that pre- and post-operative antibiotics should be prescribed to the patient receiving dental implants. There have been many antibiotic regimens used in the attempt to minimize the risks of infections and consequently, increasing the survival rate of dental implants placement procedures. However, … |
ROBERT DURAND; | 2014-07-01 |
| 188 | Knowledge and Perception of Resistance to Antimicrobials in French Healthcare Facilities PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this survey are to determine the level of antimicrobial resistance knowledge and perception of health care workers (HCW) in France, to measure the impact of health care facilities (HCF) and to identify the drivers and barriers to change. To achieve this goal, a cross-sectional survey on one day with a self-administered questionnaire and semi-structured interviews with HCWs is proposed. This study will be planned in 60 different HCFs randomly selected and expected to include of 2,100 to 10,000 respondents. |
JEAN CHRISTOPHE LUCET; | 2014-06-01 |
| 189 | A Multicenter, 3-Stage Cluster Randomized Historically-Controlled Crossover Trial to Determine The Feasibility and Outcomes From Two Antimicrobial Stewardship Interventions in Community Hospitals PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The Infectious Diseases Society of America (IDSA) guidelines recommend two core strategies for Antibiotic Stewardship (AS): 1) antimicrobial restriction and preauthorization and 2) prospective audit with intervention and feedback. Community hospitals have limited or no resources and staff dedicated to AS. Thus, understanding which of the core strategies is most feasible and effective in this practice setting would assist in appropriate allocation of limited resources. The purpose of this study is to evaluate the feasibility of implementing antimicrobial restriction and preauthorization vs. post antibiotic prescription review in resource-limited community hospitals. |
DEVERICK J ANDERSON; | 2014-05-01 |
| 190 | Safety and Efficacy of Intranasal and Topical Mupirocin in Eradicating Colonization With Staphylococcus Aureus (SA) in Critically Ill Infants – A Phase 2, Multi-Center, Open Label, Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this trial is 1) to evaluate the safety and clinical acceptability of a 5-day course of mupirocin applied every 8 hours (± 2 hours) to the nares, umbilical and perianal areas of infants residing in the ICU. 2) to examine the efficacy of mupirocin in eradicating SA colonization of infants in the ICU, defined as the absence of SA in cultures of the nares, umbilical, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2014-04-30 |
| 191 | Checklist to Prevent MRSA Surgical Site Infections PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goals of this project are 1) to assess the effectiveness and cost-effectiveness of the checklist to prevent MRSA SSIs among Veterans undergoing TJA or cardiac surgery, … |
ELI N. PERENCEVICH; | 2014-04-01 |
| 192 | ADRN Barrier/Immunoprofiling Exploratory Pilot Study (ADRN-04) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to look at how defects in the skin barrier and immune response affect risk for skin infections. Participants will be classified into 4 groups based on Atopic Dermatitis (AD)/Non-Atopic (NA) status and Staphylococcus aureus (S. aureus) colonization (negative or positive): – AD S. aureus negative – AD S. aureus positive – NA S. aureus negative and – NA S. aureus positive. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2014-04-01 |
| 193 | Cluster-Randomized Controlled Trial of Hospitals to Reduce Healthcare-Associated Infections and Readmissions Through Routine Bathing With Antiseptic Soap and Targeted Use of Nasal Antibiotic Ointment (ABATE Infection Trial) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The ABATE Infection Project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. The two strategies to be evaluated are: – Arm 1: Routine Care Routine policy for showering/bathing – Arm 2: Decolonization Use of chlorhexidine as routine soap for showering or bed bathing for all patients Mupirocin x 5 days if MRSA+ by history, culture, or screen Note that enrolled subjects represents 53 individual HCA Hospitals (representing ~190 non-critical care units) that have been randomized. |
SUSAN HUANG; | 2014-04-01 |
| 194 | A Comparison of Medihoney® Gel With Active Leptospermum Honey and Santyl® in The Treatment of Partial Thickness Burns PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to assess the efficacy of MEDIHONEY® Gel with Active leptospermum honey dressing relative to SANTYL® ointment dressing on time to heal, bacterial growth in the wound, patient satisfaction, and treatment costs in patients with partial thickness burns. The study has four hypotheses: 1. It is hypothesized that MEDIHONEY® Gel with Active leptospermum honey will result in significantly faster wound healing (i.e., … |
CHRISTINA DUNCAN; | 2014-03-15 |
| 195 | Impact MRSA -PCR on Patient Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphylococcus aureus represents one of the most met germs, with Escherichia coli, during bacteremia. Microbiologist distinguish at aureus S. two profiles of resistance in beta-lactamines: S. aureus sensitive to the methicillin ( SASM) and the S. aureus resistant to the methicillin ( SARM). With the implementation of the MALDI-TOF, it is now possible to identify the origin responsible of the bacteremia the day of the positivity of the hemoculture ( J0) and to set up a treatment with adapted antibiotic, which, in the case of a sepsis to aureus S., is the vancomycine. Ye it was demonstrated, … |
MIZRAHI ASSAF; | 2014-02-01 |
| 196 | Effect of Copper Impregnated Textiles on Healthcare Associated Infections and Antibiotic Use in A Single Intensive Care Unit PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective Infection Control study comparing rates of antibiotic usage and infections in the General Intensive Care Unit (GICU) in beds with copper impregnated linens versus regular linens. |
SHIVANJALI SHANKARAN; | 2014-01-01 |
| 197 | Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin in The Treatment of Methicillin-resistant Staphylococcus Aureus（MRSA） Blood Stream Infection (Septicemia) and Endocarditis in Chinese Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Drug resistance of G+ cocci is a severe healthcare problem. According to the Ministry of Health National Antimicrobial Resistant Investigation Net (mohnarin) surveillance report, the isolation rate of MRSA is some 60% in China. MRSA infection has become a serious clinical problem; 2. Vancomycin is a bactericidal glycopeptide antibiotic which inhibits bacterial growth by hindering the synthesis of cell wall in bacteria. It exerts strong antibiotic effect to Gram+ bacteria. It is indicated for serious staphylococcus infections especially MRSA infection and has become the gold standard agent in MRSA treatment; 3. Vancomycin is a time-dependent antibiotic, … |
YONG-HONG XIAO; | 2014-01-01 |
| 198 | Controling Intestinal Colonization of High Risk Patients With Extended Spectrum ß-Lactamase Producing Enterobacteriaceae (ESBL-E) – A Randomized Trial (CLEAR) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rapid and rational health-care interventions are of great importance to efficiently combat the emergence of resistant and virulent bacteria. In recent years, spread of ESBL-E on a global level has been observed. For ESBL-E, effective eradication regimens are not yet available. The current study therefore aims to assess a new approach to ESBL-E eradication. To avoid administration of the eradication regimen to patients at low risk of subsequent BSI with ESBL-E, the study population will be restricted to immunocompromised high-risk patients. |
MARIA J.G.T. VEHRESCHILD; | 2014-01-01 |
| 199 | Stop Community MRSA Colonization Among Patients (SUSTAIN) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research is being done to learn more about an approach to remove Methicillin resistant Staphylococcus aureus (MRSA) in patients who are carriers of the bacteria in outpatient settings and among their household members and sexual partners. MRSA is a type of bacteria or germ that can cause bad infections of the skin that can make people very sick. The bacteria have been seen in a high number of persons in the Baltimore area and in hospitals throughout the country. MRSA can be spread from person to person, … |
JASON E FARLEY; | 2014-01-01 |
| 200 | A Multi-centre Open Label Randomized Controlled Phase IIB Trial Comparing Vancomycin Versus Daptomycin for The Treatment of MRSA Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to compare the efficacy of daptomycin treatment versus vancomycin treatment in the treatment of methicillin resistant staphylococcus aureus (MRSA) bloodstream infections (BSI) due to isolates with high vancomycin minimum inhibitory concentrations (MIC) (i.e. > or equal to 1.5 ug/ml) in terms of reducing all-cause mortality. Our secondary aim is to compare clinical failure rates of daptomycin treatment versus vancomycin treatment and to compare time to microbiological clearance in patients treated with daptomycin versus those treated with vancomycin. Our primary hypothesis is that Daptomycin treatment is superior to vancomycin treatment in reducing mortality from BSIs due to MRSA with high vancomycin MIC from 25% to 10%. |
THUAN TONG TAN; | 2014-01-01 |
| 201 | Clinical and Economic Impact of A Rapid Test for Detection of Methicillin-resistant Staphylococcus Aureus (MRSA) From Sterile Sites (the Alere™ PBP2a) Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the impact of the Alere™ PBP2a test combined with pharmacist review of antimicrobial therapy, on clinical outcomes and cost in hospitalized patients with sterile site S. aureus infection. |
RITU BANERJEE; | 2014-01-01 |
| 202 | RGNOSIS: Ecological Effects of Decolonisation Strategies in Intensive Care PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Previous research has shown that applying certain treatments can reduce both the number of infections and the presence of resistant bacteria in the intensive care (ICU) and its patients. These treatments have been used as standard care throughout the world for many years, … |
MJM BONTEN; | 2013-12-01 |
| 203 | Early Oral Switch Therapy in Low-risk Staphylococcus Aureus Bloodstream Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Increasing resistance to antibiotic agents has been recognized as a major health problem worldwide that will even aggravate due to the lack of new antimicrobial agents within the next decade [1]. This threat underscores the need to maximize clinical utility of existing antibiotics, through more rational prescription, … |
ACHIM J KAASCH; | 2013-12-01 |
| 204 | Randomized Multicenter Study to Assess Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin Monotherapy for Treatment of Methicillin Resistant Staphylococcus Aureus Bacteremia in Hospitalized Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To demonstrate that the combination of daptomycin and fosfomycin is superior to daptomycin alone in the treatment of methicillin resistant Staphylococcus aureus (MRSA) bacteremia. |
MIQUEL PUJOL; | 2013-12-01 |
| 205 | A Prospective, Randomized, Open-label, Active-controlled, Multicenter Study to Evaluate The Efficacy and Safety of BAY 1192631 in Japanese Patients With MRSA Infections (Skin and Soft Tissue Infection [SSTI] and SSTI-related Bacteremia) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to see the efficacy and safety of BAY1192631 in Japanese patients with methicillin-resistant staphylococcus aureus (MRSA) (skin and soft tissue infections (SSTI) and SSTI-related bacteremia). |
BAYER | 2013-11-23 |
| 206 | Impact of Cleansing With Chlorhexidine Gluconate (CHG) on Reducing Central Line Associated Bloodstream Infection (CLABSI) and Acquisition of Multi-drug Resistant Organisms (MDRO) in Children With Cancer or Those Receiving Allogeneic Hematopoietic Cell Transplantation (HCT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized phase III trial studies chlorhexidine gluconate cleansing to see how well it works compared to control cleansing in preventing central line associated bloodstream infection and acquisition of multi-drug resistant organisms in younger patients with cancer or undergoing donor stem cell transplant. Chlorhexidine gluconate may help reduce bloodstream infections and bacterial infections associated with the central line. |
DANIELLE M ZERR; | 2013-11-04 |
| 207 | A Pragmatic Crossover Cluster Randomised Study of Electronic Compliance Monitoring of Staff Hand Sanitisation in Critical Care (HANDS Study) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: If patients acquire a new infection whilst in hospital this can cause significant morbidity, prolonged hospitalisation and even death. Indeed, there is much public concern about infections such as MRSA. Patients who require intensive care are probably at the greatest risk. Appropriate hand hygiene by healthcare workers can reduce infection rates and is a key goal of many patient safety initiatives. Worldwide, hand hygiene compliance has been estimated at only 38.7% despite the intervention being simple and cheap. Reasons for poor compliance include lack of time, skin irritation, lack of facilities, intensity of workload and forgetfulness. Furthermore, … |
PATRICIA CATTINI; | 2013-11-01 |
| 208 | Impact of Mupirocin Decolonization on The Nasal Microbiome Related Papers Related Patents Related Grants Related Experts View Highlight: The normal bacteria that inhabit the human nose, also known as the nasal microbiome, may serve as a host defense mechanism against colonization and infection by Staphylococcus aureus, including methicillin resistant S. aureus (MRSA). Mupirocin is a topical antibacterial agent that may be used to clear nasal colonization with S. aureus, and reduce risk of S. aureus infection. The impact of mupirocin on the normal nasal microbiome is not known. We hypothesize that the nasal microbiome is changed by mupirocin. Our study aims to define the nasal microbiome before and after decolonization therapy with mupirocin. |
MARY T BESSESEN; | 2013-10-01 |
| 209 | A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate The Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine whether daptomycin is effective and safe in the treatment of pediatric participants with AHO when compared to vancomycin (or equivalent) or nafcillin (or β-lactam equivalent). The primary hypothesis is that daptomycin is non-inferior compared with vancomycin (or equivalent) or nafcillin (or β-lactam equivalent) with respect to improvement in Pain, Inflammation, and Limb Function on or before study Day 5. |
CUBIST PHARMACEUTICALS | 2013-09-13 |
| 210 | Randomized Controlled Clinical Trial of 2% Chlorhexidine Gluconate-Impregnated Bath Cloths to Prevent MRSA Colonization on Complex Continuing Care Units of Baycrest Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether daily bathing with 2% chlorhexidine gluconate-impregnated antiseptic cleanser (CHG) significantly reduces incidence of colonization of hospitalized patients with methicillin-resistant Staphylococcus aureus (MRSA). Investigators postulate that daily bathing with CHG significantly reduces incidence of colonization of hospitalized patients with MRSA. |
CHINGIZ AMIROV; | 2013-08-01 |
| 211 | Optimal Two-Stage Phase 2 Study of Efficacy and Pharmacokinetics of Aerosolized Vancomycin in Methicillin-Resistant Staphylococcus Aureus Pneumonia Under Mechanical Ventilation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether aerosolized vancomycin is effective in the treatment of methicillin-resistant staphylococcus aureus pneumonia under mechanical ventilation. |
SEOUL NATIONAL UNIVERSITY HOSPITAL | 2013-08-01 |
| 212 | Fecal Microbiota Transplantation Restores Dysbiosis in Patients With Methicillin Resistant Staphylococcus Aureus Enterocolitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major sources of nosocomial infection. Along with the widely application of antibiotics around perioperative period, MRSA infection is increasing by years.Fecal microbial transplantation (FMT),infusion of fecal preparation from a healthy donor into the GI tract of a patient is being proposed as a novel therapeutic approach to modulate diseases associated with pathological imbalances within the resident microbiota, termed dysbiosis.It has been used to treat intestinal disease such as inflammatory bowel diseases and Clostridium difficile infection, … |
JINLING HOSPITAL CHINA | 2013-07-01 |
| 213 | Simplified Selective Digestive Tract Decontamination for The Prevention of ICU Infections in The Setting of High-level Antibiotic Resistance PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A simplified graded gut decontamination protocol combined with rigorous bi-weekly screening and appropriate bacterial prophylaxis, will lead to a 25% reduction in the acquisition of blood stream infections and to a 25% reduction in lower airway colonization with multi drug resistant organisms. There will be no concomitant rise in gram-positive or fungal infection or a surgency of new resistance patterns. |
MICAL PAUL; | 2013-06-01 |
| 214 | Individualized Vs. Household Eradication of MRSA in Households With Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to compare the effectiveness of commonly used decolonization treatments (application of mupirocin antibiotic ointment to the nose and bleach baths) when performed by individuals with a history of skin and soft tissue infection (SSTI) in the prior year (individualized approach) in comparison to decolonization of all household members (household approach) in an attempt to prevent Staphylococcus aureus skin infections. The investigators hypothesize an individualized decolonization approach will be equally as effective as a household approach to prevent SSTI. |
STEPHANIE A. FRITZ; | 2013-04-01 |
| 215 | New Mexico Honey Wound Treatment Research Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In a time of emerging bacteria that are resistant to antibiotics, honey offers an alternative that has potential to reduce the heavy reliance on pharmaceutical antibiotics. We will be evaluating the effectiveness of a locally produced New Mexico Honey against the standard of care Bactrim antibiotic on Community Acquired MRSA. |
R. STEPHEN RANKIN; | 2013-03-01 |
| 216 | A Phase 2, Randomized, Double Blind, Placebo-controlled Study of AeroVanc for The Treatment of Persistent Methicillin-resistant Staphylococcus Aureus Lung Infection in Cystic Fibrosis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether AeroVanc treatment is safe and effective in reducing the number of MRSA colony forming units in the lungs of cystic fibrosis patients. |
ELLIOTT DASENBROOK; | 2013-03-01 |
| 217 | Clinical Characteristics and Microbiology of Healthcare Associated Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Background The prediction of multi-drug resistant (MDR) pathogens is a key issue in the management of health-care associated pneumonia (HCAP). Multiple risk factors have been proposed, some of which overlap with items of the pneumonia severity index (PSI). The aim of this study was to investigate the relationship between PSI and presence of MDR pathogens. Methods Patients who were admitted to a tertiary-care hospital from January 2005 to December 2010 were screened by a discharge diagnosis of pneumonia. Patients were enrolled if they fulfilled the definition of HCAP by 2005 ATS/IDSA guideline. |
PING-HUAI WANG; | 2013-02-01 |
| 218 | Pharmacokinetic and Pharmacodynamic Evaluation of Linezolid Administered Intravenously in MRSA-positive, Morbidly Obese Patients With Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of the study are: (i) to evaluate the proportion of patients who attain a T>MIC (Minimum Inhibitory Concentration) of 100% and the time frame in which they do so. The investigators therefore plan to measure unbound linezolid trough concentrations before administration of the second, third, fourth and fifth dose. Furthermore, the investigators will assess the AUC0 – 24h/MIC in all study subjects. Therefore, multiple plasma samples will be drawn after the fourth or fifth dose, … |
DIRK VOGELAERS; | 2013-02-01 |
| 219 | A Multicenter, 2-Cohort Study to Describe The Safety and Efficacy of Ceftaroline Fosamil in Subjects With Staphylococcus Aureus Bacteremia or With Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study of safety and efficacy of ceftaroline fosamil in Subjects with Staphylococcus aureus Bacteremia or with Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia persisting after at least 72 hours of vancomycin and/or daptomycin treatment. |
FOREST LABORATORIES | 2013-01-01 |
| 220 | Clinical Outcomes Among A National Veterans Affairs Methicillin Resistant Staphylococcus Aureus (MRSA) Pneumonia Cohort Treated With Linezolid Or Vancomycin PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this non-interventional, retrospective study of existing data is to evaluate clinical outcomes related to Methicillin-resistant Staphylococcus aureus hospital based pneumonia by treatment and among subpopulations. |
PFIZER | 2012-12-01 |
| 221 | Uncontrolled, Open-label, Phase II Pilot Study to Evaluate The Efficacy, Tolerability and Acceptability of 200mg/g Tea Tree Oil Gel Applied Topically Twice Daily for The Treatment of Mild to Moderate Facial Acne PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild to moderate facial acne is an extremely common disease of teenagers and young adults. This pilot study will investigate whether treatment with a gel containing tea tree oil reduces numbers of acne lesions and improves acne in twenty otherwise healthy consenting participants. The hypothesis is that treatment with tea tree oil gel will result in a significant improvement in acne after 12 weeks of treatment. |
KATHERINE HAMMER; | 2012-12-01 |
| 222 | A Case Series of Ceftaroline-treated Patients With Infections Caused By MRSA That Are Susceptible to Ceftaroline, Compared to Vancomycin-treated Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the time to pathogen eradication, and the relationship to the time to clinical improvement, between ceftaroline and case-matched vancomycin treated controls in the treatment of adults with serious infections caused by Methicillin-Resistant Staphylococcus aureus (MRSA). |
JEROME SCHENTAG; | 2012-12-01 |
| 223 | A Randomized Double-Blind Placebo-Controlled Study to Determine Safety of P128 Applied to Nares of Healthy Volunteers and Safety And Efficacy of Any Patient Including Chronic Kidney Disease Patients Who Are Nasal Carriers of S.Aureus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether the antibacterial protein P128 is (i) safe and well tolerated in healthy volunteers and in chronic kidney diseases patients on dialysis, (ii) is it effective in reducing the nasal carriage of pathogen (Staphylococcus aureus) in humans. |
DALE A FISHER; | 2012-12-01 |
| 224 | A Comparative Evaluation of The Safety and Efficacy of Daptomycin Versus Standard of Care in Pediatric Subjects One – Seventeen Years of Age With Bacteremia Caused By Staphylococcus Aureus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The intent of this study is to describe the safety and efficacy of daptomycin versus standard of care (SOC) in pediatric participants aged 1-17 years with bacteremia caused by Staphylococcus aureus (S. aureus). |
CUBIST PHARMACEUTICALS | 2012-11-29 |
| 225 | Efficacy of Copper in Reducing Health-Acquired Infections and Microbial Burden As Measured on High Touch Surfaces in A Pediatric Intensive Care Unit. A Controlled Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Healthcare-acquired infections (HAI) cause substantial patient morbidity and mortality. Commonly touched items in the patient care environment harbor microorganisms that may contribute to HAI risk. The purpose of this study is to assess whether placement of copper-alloy surfaced objects in a pediatric intensive care unit (PICU) reduce risk of HAI in comparison with non-copper surfaced objects. |
BETTINA VON DESSAUER; | 2012-11-01 |
| 226 | Gown and Glove Use to Prevent The Spread of Infection in VA Community Living Centers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Methicillin-resistant S. aureus (MRSA) infections are a common cause of morbidity and mortality in nursing home residents. MRSA is predominantly spread from patient-to-patient by health care workers. The use of gowns, gloves and hand washing prevents this spread; however, their use detracts from a patient-centered, home-like environment which is an important priority for nursing homes. The goal of this project is to determine when it is most important for health care workers to wear gowns and to wash their hands when caring for MRSA colonized Veterans in community living centers. |
MARY-CLAIRE ROGHMANN; | 2012-10-01 |
| 227 | Persistent MRSA Eradication Protocol (PMEP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The prevalence of methicillin resistant Staphylococcus aureus (MRSA) respiratory infection in Cystic Fibrosis (CF) has increased dramatically over the last decade. Evidence suggests that persistent infection with MRSA may result in an increased rate of decline in Forced Expiratory Volume (FEV)1 and shortened survival. Currently there are no conclusive studies demonstrating an effective aggressive treatment protocol for persistent MRSA respiratory infection in CF. Data demonstrating an effective and safe method of clearing persistent MRSA infection are needed. The purpose of this study is to evaluate the safety and efficacy of a 28-day course of vancomycin for inhalation, … |
MICHAEL P BOYLE; | 2012-10-01 |
| 228 | A Multicenter, Multinational, Randomized, Double-blind Study to Evaluate The Efficacy and Safety of Ceftaroline Fosamil Versus Ceftriaxone Plus Vancomycin in Adult Subjects With Community-acquired Bacterial Pneumonia at Risk for Infection Due to Methicillin-resistant Staphylococcus Aureus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether ceftaroline is effective and safe for the treatment of patients with Community-acquired Bacterial Pneumonia (CABP) at risk for infection due to Methicillin-resistant Staphylococcus aureus (MRSA). |
FOREST LABORATORIES | 2012-10-01 |
| 229 | A Multicenter, Randomized, Observer-Blinded, Active-Controlled Study Evaluating The Safety, Tolerability, Pharmacokinetics, and Efficacy of Ceftaroline Versus Ceftriaxone Plus Vancomycin in Pediatric Subjects With Complicated Community-acquired Bacterial Pneumonia (CABP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study of safety and effectiveness of ceftaroline fosamil in children with Complicated Community-acquired Pneumonia receiving antibiotic therapy in the hospital. |
FOREST LABORATORIES | 2012-10-01 |
| 230 | Comparison of Contamination Rates of Medication Storage Cabinets Between Isolation and Non-isolation Rooms With Methicillin-resistant Staphylococcus Aureus (MRSA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to determine if medication cabinets located outside of isolation rooms in hospitals and their contents, particularly medications and the delivery folders are at a higher risk of having harmful bacteria on them. |
MICHAEL SWEET; | 2012-08-01 |
| 231 | Retapamulin for Reducing MRSA Nasal Carriage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will conduct a randomized placebo-controlled double-blinded study of nasal decolonization with retapamulin vs. placebo for the eradication of MRSA nasal carriage among adult carriers with low-level (MIC 8-256) and high-level mupirocin resistant (MIC >256) strains. Objectives: 1. To determine the percent of intervention vs. control patients with successful MRSA nasal decolonization as determined by bilateral nares swabs following a 5-day twice-a-day regimen of retapamulin. 2. To determine the time to decolonization based upon interim and final bilateral nares swabs. 3. To determine the acceptability of retapamulin by surveying participants about their experience and adverse events experienced during this study. The duration of participant follow-up is expected to last up to 7 weeks. This study will evaluate the safety and effectiveness of Altabax (retapamulin) during decolonization of MRSA carriers with mupirocin-resistant strains, stratified by low-level and high-level resistance to mupirocin. Mupirocin resistance is increasingly common and there is no approved substitute topical agent for decolonization of the MRSA nasal reservoir. |
SUSAN HUANG; | 2012-07-01 |
| 232 | A Two-Part Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Repeat IV Doses of GSK2140944 in Healthy Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: GSK2140944 belongs to the Bacterial Type II Topoisomerase Inhibitor (BTI) class of antibiotics. GSK2140944 has demonstrated in vitro and in vivo activity against Gram positive pathogens including methicillin resistant Staphylococcus aureus (MRSA) and Gram-negative pathogens associated with respiratory tract, skin and soft tissue infections including isolates resistant to existing classes of antimicrobials. |
GLAXOSMITHKLINE | 2012-06-04 |
| 233 | Prospective Study Into The Performance of The KeyPathtm MRSA/MSSA Blood Culture Test – BTA PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In vitro identification of S. aureus,methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA)from positive blood culture using MicroPhage’s bacteriophage-based diagnostic platform. |
DIPANKAR MANNA; | 2012-06-01 |
| 234 | Phase 2a, Repeated-dose, Open-label, Single-arm Study of CG400549 for The Treatment of Complicated Acute Bacterial Skin and Skin Structure Infection (cABSSSI) Caused By Methicillin-resistant Staphylococcus Aureus (MRSA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Objective: To make a preliminary assessment of the efficacy of CG400549 (960 mg daily) in subjects with cABSSSI (major cutaneous abscesses) due to MRSA. Secondary Objective(s): – To assess the pharmacokinetics of CG400549 (960 mg daily) in subjects with cABSSSI due to MRSA – To explore the in vitro susceptibility of cABSSSI-related bacteria to CG400549. – To assess the safety of multiple doses of CG400459 |
JEFFREY S. OVERCASH; | 2012-06-01 |
| 235 | Effectiveness of Vancomycin Loading Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of tish clinical research study is to identify that loading of vancomycin can facilitate rapid attainment of target trough serum vancomycin concentration. |
KYONG RAN PECK; | 2012-06-01 |
| 236 | A Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study to Assess The Safety, Pharmacokinetics, Efficacy and Pharmacodynamics of KBSA301 in Severe Pneumonia (S. Aureus) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this study are to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical outcome of patients who have severe pneumonia caused by Staphylococcus aureus (S. aureus) after a single intravenous administration of KBSA301 in addition of standard of care antibiotic treatment. |
PIERRE-FRANÇOIS M LATERRE; | 2012-05-01 |
| 237 | A Randomized, Multicenter Trial of Daptomycin Versus Vancomycin in The Treatment of Nosocomial or Healthcare-associated Methicillin-resistant Staphylococcus Aureus Bacteremia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypothesis: The use of daptomycin to treat nosocomial or healthcare-associated bacteremia due to methicillin-resistant S. aureus (MRSA) would increase the proportion of patients whose blood cultures are sterilized after 72 hours by 15% relative to vancomycin and would improve treatment safety. Hypothesis: for MRSA nosocomial or healthcare related bacteriemia treatment, the use of daptomycin versus vancomycin would increase by 15% the proportion of patients with sterilized blood cultures at 72 hours and would increase the treatment safety. Primary objective: To study the efficacy of daptomycin compared to vancomycin on the sterilization of blood cultures after 72 hours of therapy. |
BRUNO FANTIN; | 2012-05-01 |
| 238 | A Four-arm Prospective, Multicenter Study to Assess The Efficacy, Effectiveness, and Feasibility of Enhanced Terminal Room Disinfection With Chlorine and UV Light Using Clinical and Microbiologic Outcomes PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Enhanced terminal room disinfection is a novel, promising, but still unproven strategy for the prevention of healthcare-associated infections (HAIs) due to selected multidrug-resistant (MDR) bacterial pathogens. The investigators will perform a large prospective, multicenter study enhanced terminal room disinfection to 1) determine the efficacy and feasibility of enhanced terminal room disinfection strategies to prevent HAIs and 2) determine the impact of environmental contamination on acquisition of MDR-pathogens among hospitalized patients. |
DANIEL J SEXTON; | 2012-04-01 |
| 239 | The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract (PFE) for Patients With Chronic Rhinitis, Chronic Sinusitis With or Without Nasal Polyps PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: An explosion of interest in the numerous therapeutic properties of Punica granatum over the last decade has led to numerous in vitro, animal, and clinical trials. Pomegranate is a potent antioxidant, superior to red wine and equal to or better than green tea. In addition, anticarcinogenic and anti-inflammatory properties suggest its possible use as a therapy or adjunct for prevention and treatment of several types of cancer and cardiovascular disease. Because of pomegranate’s antimicrobial properties, it may aid in preventing infection by dental pathogens, pathogenic E. coli O157:H7, … |
ITZHAK BRAVERMAN; | 2012-04-01 |
| 240 | Evaluation of A Multi-modal Network to Spread An Enhanced SSI Prevention Bundle PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In 2011, IHI designed a new campaign to accelerate uptake of evidence-based practices that had been shown to prevent surgical site infections (SSI) associated with hip and knee arthroplasty. Project JOINTS (Joining Organizations IN Tackling SSIs was a multi-faceted, disciplined initiative that used the Rapid Spread Network (defined above), methods and tools developed during previous IHI campaigns to influence orthopedic practices and hospitals performing hip and knee arthroplasty. Rather than launch nationally as other campaigns have done, Project JOINTS was introduced in a cluster-randomized fashion to enable a rigorous, … |
ERIC C SCHNEIDER; | 2012-02-01 |
| 241 | Effect of Pre-operative Prophylaxis With Vancomycin on Rate of Cefazolin Non-susceptible Gram Positive Surgical Site Infections in Cardiovascular Surgery Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators hope to learn 1) if the addition of prophylaxis with vancomycin will decrease the rate of cefazolin non-susceptible surgical site infections (SSI), in high risk population 2) to develop better understanding of vancomycin and cefazolin pharmacokinetics in children undergoing cardiopulmonary bypass (CPB) 3) to assess the barriers to vancomycin dosing peri-operatively 4) to assess side effects and risks associated with peri-operative vancomycin administration. This will allow us to improve patient care by better understanding the benefits or the risks of peri-operative vancomycin administration and potentially decrease cefazolin-resistant surgical site infections. In addition, … |
CHANDRA RAMAMOORTHY; | 2012-02-01 |
| 242 | The Use of Diluted Povidone Iodine Irrigation in Spine Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine whether diluted Povidone Iodine solution used to irrigate surgical wounds during spine surgery decreases the incidence of surgical site infections. |
NAJMEDDEN ATTABIB; | 2012-01-01 |
| 243 | Methicillin-resistant Staphylococcus Aureus in A Trauma Population: Does Decolonization Prevent Infection? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: All trauma patients admitted to certain Intensive Care Units (ICU) will have Methicillin-resistant Staphylococcus aureus (MRSA) nasal swabs performed to determine MRSA colonization status. Only those patients who are determined to be colonized with MRSA at admission will be included in the study. All patients must be age 18 and older, admitted directly to the ICU from either the Emergency Department or the operating room with trauma-related injuries, and must not have active or recent known history of MRSA infections. Once patients have been determined to be colonized with MRSA, … |
LAURA BROWN; | 2012-01-01 |
| 244 | Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the pharmacokinetics and safety of inhaled vancomycin in patients with cystic fibrosis. |
ELLIOTT DASENBROOK; | 2012-01-01 |
| 245 | Bacterial Contamination of Healthcare Worker Uniforms: A Study of Antimicrobial Uniforms on Occupationally Acquired Bacterial Contamination: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Healthcare worker uniforms are frequently contaminated with bacteria known to cause infections in humans. These bacteria are acquired during the workday. A new technology of antimicrobial textiles have been developed and incorporated into the fabric of health care worker uniforms, reportedly with effectiveness rates of > 99% but there is little literature describing the effectiveness of Healthcare worker (HCW) uniforms with antimicrobial properties in the clinical setting. Because of the potential benefit that such uniforms could offer HCWs and patients alike, further investigation into whether these fabrics are effective is warranted. Up to 140 physicians, nurses, … |
MARISHA A BURDEN; | 2011-11-01 |
| 246 | Bacterial Phenotype of Staphylococcus Aureus Has No Effect on Patients’ Clinical Outcome in Orthopedic Device Related Bone Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a prospective study performed between November 2011 and September 2013. Patients with a confirmed S. aureus infection after fracture fixation or prosthetic joint infection were included. Exclusion criteria included infections involving external fixation pins, infections without any implanted hardware and culture positive patients not displaying any clinical sign of infection. The following surgical parameters were documented: affected bone or joint; type of implant; … |
MARIO MORGENSTERN; | 2011-11-01 |
| 247 | IMpact of PRObiotics for Reducing Infections in VEterans: The IMPROVE Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators have two hypotheses: (1) The probiotic L. rhamnosus HN001, when compared to placebo, will reduce S. aureus nasal colonization when taken for four weeks. (2) The probiotic L. rhamnosus HN001, when compared to placebo, will reduce S. aureus gastrointestinal colonization when taken for four weeks. |
NASIA SAFDAR; | 2011-10-01 |
| 248 | A Randomized, Single Blind, Placebo Controlled Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Escalating Oral Doses of GSK2140944 in Healthy Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: GSK2140944 belongs to the Bacterial Type II Topoisomerase Inhibitor (BTI) class of antibiotics. GSK2140944 has demonstrated in vitro and in vivo activity against Gram positive including methicillin resistant Staphylococcus aureus (MRSA) and Gram-negative pathogens associated with respiratory tract, skin and soft tissue infections including isolates resistant to existing classes of antimicrobials. This is a First Time in Human (FTIH) study to assess the safety, tolerability, and pharmacokinetics of single oral doses of GSK2140944 in healthy volunteers. This study will be a single-blind, randomized, placebo-controlled, … |
GLAXOSMITHKLINE | 2011-09-26 |
| 249 | A Randomized Study to Evaluate Comparative Effectiveness, Inpatient Resource Utilization, and Cost of Daptomycin Vs. Vancomycin in The Treatment of Patients With Complicated Skin and Skin Structure Infections Due to Suspected or Documented Methicillin-resistant Staphylococcus Aureus (MRSA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a real-world, prospective, open-label, multicenter study in which participants were randomized (1:1) to receive intravenous (IV) vancomycin or IV daptomycin. The purpose of this study is to compare infection-related hospital length of stay, along with a number of participant-reported outcomes, between participants with complicated skin and soft tissue infection treated with daptomycin and vancomycin. |
CUBIST PHARMACEUTICALS | 2011-09-09 |
| 250 | A Randomized Trial to Evaluate A Staphylococcus Eradication Protocol for Patients Who Present to The Emergency Department With Cutaneous Abscess PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators will enroll patients who present to the emergency department with abscesses to the study. The patients will be randomly selected to either have the standard of care, which includes the standard drainage of the abscess and then usually a follow-up visit to recheck the wound, … |
SCOTT G WEINER; | 2011-09-01 |
| 251 | Registry for The Atopic Dermatitis Research Network (ADRN-02) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this multi-center, clinical registry study is to determine genetic markers associated with susceptibility of AD patients to infections and to also serve as a potential participant database for future studies. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2011-08-01 |
| 252 | Use of An Enhanced Room Cleaning Protocol in The Intensive Care Unit to Reduce Contamination of Disposable Isolation Gowns and Gloves With Methicillin-resistant Staphylococcus Aureus and Multi-drug Resistant Acinetobacter Baumannii PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether extra cleaning of frequently-contaminated surfaces in intensive care rooms is effective in preventing contamination of disposable isolation gowns and gloves with multi-drug resistant bacteria. |
ANTHONY HARRIS; | 2011-08-01 |
| 253 | Understanding Hand Hygiene Behavior at Unidad Nacional Oncologia Pediatrica: A Focus Group Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Healthcare associated infections increase morbidity and mortality among all hospitalized patients, especially in those who are immunocompromised, in both developed and in countries with limited resources. However, when resources are limited, infection prevention and control measures are often overlooked by personnel and institutions. Hand hygiene has been shown numerous times to be the most effective way to prevent infections in the healthcare setting. In Unidad Nacional de Oncologia Pediatrica (UNOP) in Guatemala City, Guatemala, there have been several infrastructural improvements and periodic education and promotion activities. Still, … |
ST JUDE CHILDREN’S RESEARCH HOSPITAL | 2011-08-01 |
| 254 | A Phase 3, Multicenter, Randomized, Double-Blind Study To Evaluate The Safety And Efficacy Of Tigecycline Versus Comparator (Clindamycin Or Vancomycin) For The Treatment Of Complicated Skin And Skin Structure Infections, Including Those Due To MRSA, In Pediatric Subject Ages 8 To 17 Years Old Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to compare the safety and efficacy of tigecycline versus clindamycin (including subjects treated with vancomycin) in pediatric subjects (aged 8 to 17 years) with complicated skin and skin structure infections (cSSSI), including those caused by methicillin-resistant staphylococcus aureus (MRSA). |
WYETH IS NOW A WHOLLY OWNED SUBSIDIARY OF PFIZER | 2011-08-01 |
| 255 | Topical MRSA Bactericidal Gel to Eliminate MRSA and Promote Accelerated Healing of CSSTI of Open Wounds PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Based on personal experience and the literature it is reasonable expectation that Vancomycin is a viable treatment in a direct contact form to eliminate MRSA from open wounds in order to heal the wounds by conventional means. The key question in my research has been to measure the effectiveness of my Vancomycin Gel by culturing the wound, applying the Gel in a controlled manner and then culturing the wound after one week. The end point to achieve in the process, … |
ROBERT S BERMAN; | 2011-07-15 |
| 256 | Epidemiological Study of Methicillin-resistant Staphylococcus Aureus (MRSA) Isolated From Infected Patients During A Hospital Surveillance Period PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project has as general objective to determine if there is any Methicillin-resistant Staphylococcus aureus (MRSA) strain disseminating in the hospital of Belo Horizonte. If this is the case, the investigators will determine if this is an international known strain by typing it by PFGE and MLST. The detection of mecA gene will be performed by PCR. Their susceptibility profile to several drugs will also be accessed and it will be possible to compare the response to those drugs commonly in use to that of Daptomycin, … |
ILANA L B CAMARGO; | 2011-07-01 |
| 257 | Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatment Related Papers Related Patents Related Grants Related Experts View Highlight: Objective of the study is to test whether Daptomycin (6 mg/kg bodyweight) is non-inferior in treatment of severe diabetic foot infections (MRSA) in comparison to antibiotic treatment with Vancomycin (effective blood-plasma concentration of 15 mg/l). In case of microbiologically confirmed gram-negative co-infection effective antibiotic treatment according to microbiologic analysis will be administered upon medical decision in both therapy groups. The study will be carried out as a randomized, open label study. |
DIETHELM TSCHOEPE; | 2011-07-01 |
| 258 | Epidemiology of Rural MRSA : Is Livestock Contact A Risk Factor? PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: – MRSA is a type of bacteria that causes serious health problems. It can cause severe infections and is difficult to treat. MRSA has been found in a high number of people who work with some kinds of livestock, such as pigs. Researchers want to study people in rural areas, where more people work with or around livestock. They want to see if MRSA is more common or causes more serious infections in these areas. Objectives: – To look at the relationship between livestock handling (especially pigs) and MRSA bacteria in people in rural areas. Eligibility: – … |
LAURA BEANE-FREEMAN; | 2011-06-01 |
| 259 | Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Vitro and in Ventilator-associated Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As previous studies showed that the synergy between linezolid and carbapenem in vitro and in vivo (animal studies), our study is aim to investigate the activity of linezolid, alone and in combination with carbapenem against methicillin-resistant Staphylococcus aureus (MRSA) in ventilator-associated pneumonia (VAP) patients. |
HONG-PING QU; | 2011-06-01 |
| 260 | A Systematic Oral Care Program in Post-Mechanically Ventilated, Post-Intensive Care Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to see if a 4 day oral care program in patients who have been on a breathing machine results in better oral health, reduces the amount of certain bacteria in the mouth and reduces infection while in the hospital. The plan is to test the specific hypotheses that a standardized oral care protocol: 1. Results in improved oral health compared to standard care, 2. Reduces the rate of Staphylococcus aureus / methicillin resistant Staphylococcus aureus, and 3. Reduces the risk of healthcare-associated infections. |
ESTHER CHIPPS; | 2011-06-01 |
| 261 | Vancomycin Versus Daptomycin for The Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations (MICs) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is an increased failure rate for the treatment of Staphylococcus Aureus Bacteremia (SAB) with traditional doses of vancomycin, the standard of care for patients with MRSA bacteremia over the last 40 years. This has been largely attributed to isolates with increased resistance to vancomycin (increased MIC). Daptomycin is an antibiotic that was approved several years ago for the treatment of SAB and is being increasingly used for MRSA bacteremia due to isolates with increased MIC. Increased doses have been recommended for both of these drugs in the treatment of this infection without a trial demonstrating their relative efficacy or safety at higher doses. This study will randomize patients with SAB due to MRSA with an increased MIC to determine the relative efficacy and safety of vancomycin and daptomycin used at higher than traditional doses. |
LEONARD B. JOHNSON; | 2011-06-01 |
| 262 | Double Blinded Prospective Randomized Controlled Trial Comparing Cefazolin Plus Vancomycin Versus Cefazolin Plus Daptomycin for Vascular Surgery Prophylaxis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current recommended antibiotic, Cefazolin, treatment for vascular surgery, provides coverage only for Methicillin-Sensitive Staphylococcus Aureaus (MSSA), other gram-positive bacteria, and some gram-negative bacteria which may not be adequate antibiotic treatment at the time of vascular surgery and result in an increased hospital length of stay, increased cost of care, and an increased risk of morbidity and mortality as a consequence of surgical site infections. Thus, … |
PATRICK STONE; | 2011-05-01 |
| 263 | Early MRSA Therapy in CF – Culture Based Vs. Observant Therapy (Treat or Observe) (Star-TOO – STaph Aureus Resistance – Treat or Observe) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose: There has been a recent, rapid increase in prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) among patients with Cystic Fibrosis (22% across US CF centers in 2009). Some epidemiologic studies suggest possible worse outcomes, a recent analyses showing this with chronic but not intermittent MRSA. Given the chronic difficult to treat lung infections in CF it is unclear how the onset of MRSA should be approached. This randomized, controlled, … |
MARIANNE MUHLEBACH; | 2011-04-01 |
| 264 | Observational Study to Assess Clinical Management Patterns in Patients With Hospitalised Community-Acquired Pneumonia (CAP) or Complicated Skin and Skin Structure Infections (cSSSI) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will collect real-life data from patients with community acquired pneumonia (CAP) OR complicated skin and skin structure infections (cSSSI) to assess the burden of the disease, review the treatment pathways, evaluate how health resources are used and identify any areas of unmet medical needs. The aim of the study is to compare how patients who are admitted to hospital with CAP or cSSSI are managed across Europe. This will be done by collecting data to understand the patient and disease characteristics, current practice of treatment, … |
ASTRAZENECA | 2011-03-01 |
| 265 | MESS- MRSA Eradication Study Skåne. A Comparison Between Systemic Antibiotic Treatment in Combination With Topical Mupirocintreatment With Only Topical Mupiroicintreatment to Eradicate MRSA in Throat Carriers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether systemic antibiotic treatment with rifampicin and clindamycine or trimethoprim-sulfa in addition to topical treatment with mupirocin is more effective than only topical treatment to eradicate MRSA in throatcarriers |
EVA MELANDER; | 2011-03-01 |
| 266 | Prospectively Observational Evaluation of Clinical Outcomes in Two-stage Reimplantation for Infected Knee Arthroplasty Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Total knee arthroplasty (TKA) infection is a complication requiring multiple hospitalizations, operations, and outpatient visits placing a significant burden on both patient and treating surgeons. When revision surgery is needed, two kinds of treatment can be applied—-one-stage and two-stage reimplantation procedure. The two-stage reimplantation procedure is considered the gold standard for treatment of subacute and chronic deep periprosthetic infections. Placement of antibiotic-loaded spacer is a standard procedure for eradication of peri-prosthetic joint infection. For better patient outcome, the purpose of this study was to determine the success rate of total knee infection patients treating with two-stage reimplantation procedure. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2011-03-01 |
| 267 | Bacterial Contamination of Critical Care Observation Charts: A Randomized Trial Comparing Matt and Antimicrobial Cellomed Laminates PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Sepsis contributes to nearly 20% of all hospital deaths and is the leading cause of death on non-coronary intensive care units. Contamination of the patient environment is common with organisms such as MRSA, VRE and C.difficile remaining viable for days or weeks on a variety materials and surfaces. Up to 90% of patient notes and charts on critical care may be contaminated with potential pathogens including MRSA and it has been shown that healthcare workers may contaminate hospital paperwork with organisms originating from patients. Cellomed is a triclosan based laminate which has been shown to possess antimicrobial activity against MRSA, … |
RICHARD C HIXSON; | 2011-02-01 |
| 268 | Project CLEAR – Changing Lives By Eradicating Antibiotic Resistance PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial will compare strategies to reduce the risk of methicillin-resistant Staphylococcus aureus (MRSA) infection and re-hospitalization in MRSA carriers. This trial will provide critical answers about the role of decolonization versus standard-of-care education in preventing MRSA infections in the large group of high risk MRSA-positive patients being discharged from hospitals. Findings could potentially impact best practice for the 1.8 million MRSA carriers who are discharged from US hospitals each year. |
SUSAN HUANG; | 2011-01-01 |
| 269 | Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphylococcus aureus, the most virulent of the many staphylococcal species, has been recognized as one of the most important and lethal human bacterial pathogens. With the increased incidence of methicillin-resistant staphylococcus aureus (MRSA) infection in community and hospitalized patients, MRSA infections are associated with greater lengths of stay, higher mortality, and increased costs. Vancomycin and teicoplanin, are the two most commonly used glycopeptides and are the first-choice of treatment for MRSA infection. Vancomycin-induced nephrotoxicity is still a point of controversy. Teicoplanin is not known to have any nephrotoxicity. Acute kidney injury is a common complication of critical illness, … |
YUH-MOU SUE; | 2011-01-01 |
| 270 | Community-acquired Methicillin-Resistant Staphylococcus Aureus Carriage Among Athletes: A Study in Limousin. : CA-MRSA PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There are only very few data about the prevalence of CA-MRSA in France and no in athletes. In USA, the clone USA300 is widely disseminated and in Europe the clone ST80 predominates. The aim of the study was to study the carriage of S. aureus in athletes in a French county (Limousin) and to evaluate the proportion of CA-MRSA. The athletes will be met during their training, each one will fill-in a clinical information questionnaire. Nasal, throat, … |
UNIVERSITY HOSPITAL LIMOGES | 2011-01-01 |
| 271 | Effect of The Use of Universal Glove and Gowning on Healthcare Associated Infection Rates and Antibiotic Resistant Bacteria PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test if doctors, nurses and other people who take care of patients in hospitals wearing gloves and gown for all contact with patients in an intensive care unit (ICU) will: – Decrease the chance of patients getting an infection while in the hospital – Decrease the chance of patients picking up bacteria as a result of being in the hospital – Decrease the time a patient spends in the ICU or in the hospital – Increase the frequency of adverse events The study will also look at whether making doctors, … |
ANTHONY HARRIS; | 2010-12-01 |
| 272 | A Novel Approach to MRSA Screening of Colonized Patients and Impact on Hospital Resource Allocation and Patient Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in hospital settings. Colonization with MRSA puts patients at increased risk for invasive infections, and MRSA infections have been associated with high costs and adverse clinic outcomes. Patients can clear MRSA spontaneously. Improved approaches for identifying patients who are no longer colonized are needed; we hypothesize that more sensitive nucleic acid amplification can be used to improve identification of patients who are no longer colonized. |
ERICA S. SHENOY; | 2010-12-01 |
| 273 | Pharmacokinetics of Linezolid in Children With Cystic Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the pharmacokinetic profile of IV (intravenous) and PO (oral) formulations of linezolid among children with cystic fibrosis and establish a dose regimen that will be safe and effective. |
JANE SIEGEL; | 2010-12-01 |
| 274 | Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion Related Papers Related Patents Related Grants Related Experts View Highlight: This study focuses on a new drug delivery system (Direct Antibiotic Delivery) to treat soft tissue infections. In this study, cefazolin is delivered directly to the target tissues using subcutaneous injection of antibiotic solution and then dispersed using high-frequency external ultrasound. Using this system, a much higher concentration of antibiotic can be achieved than through traditional treatment methods. Unlike traditional delivery methods, Direct Antibiotic Delivery does not rely on blood supply and is beneficial for subjects with Diabetes or subjects who have received radiation therapy and blood supply is limited. |
BARRY N SILBERG; | 2010-11-08 |
| 275 | Impact of Specific Antibiotic Therapies on The Prevalence of Human Host Resistant Bacteria in Hospitalised Patients (SATURN 04) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is the WP4 of the EU-funded (7th FW) project SATURN (Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria). A total of 6 surgical and 6 medical wards will participate in the study. Sites of the study are located in 3 countries (Italy, Serbia, Romania). This WP will compare nosocomial acquisition rates of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing gram-negative bacteria (E.coli, Klebsiella spp. and Proteus spp.) among different treatment groups and define the temporal relationship between the start of antibiotic therapy, the acquisition of new colonisation in patients previously not colonised, … |
CATHOLIC UNIVERSITY OF THE SACRED HEART | 2010-11-01 |
| 276 | A Randomised Controlled Trial of Atorvastatin As An Anti-Inflammatory Agent in Non-Cystic Fibrosis Bronchiectasis in Patients With Pseudomonas Aeruginosa PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Statins are a class of drug used to prevent heart attacks and strokes by lowering blood cholesterol levels. They have also been found to have a beneficial side effect of lowering the level of inflammation in the body. This is thought to be one of the reasons they are effective in treating heart attacks and strokes. Laboratory experiments have shown that statins reduce lung inflammation in response to bacteria and this is a promising development for the treatment of chest infections. Bronchiectasis is a chronic disabling lung disease characterised by chronic sputum production and recurrent chest infections. 2/3 of patients are chronically colonised with bacteria (normally the lungs are sterile) and this leads inflammation in the lung and in the rest of the body. There are no effective treatments for bronchiectasis other than antibiotics for chest infections. With increasing antibiotic use, there is increasing antibiotic resistance and new treatments for this disease are needed. The investigators intend to study Atorvastatin in patients with bronchiectasis with colonization with pseudomonas aeruginosa. The investigators will give Atorvastatin to 16 patients with this disease while 16 patients will receive placebo. This will be a crossover study where patients will receive atorvastatin or placebo for 3 months, followed by a statin wash out period of 6 weeks. Thereafter the groups will cross over and the group receiving atorvastatin will now receive placebo and those receiving placebo will receive atorvastatin for 3 months. The investigators will measure inflammation in their lungs and in the rest of their body before and after treatment with atorvastatin. The investigators will also assess their quality of life and number of chest infections over a 7.5 month period. This pilot study will determine if there is any role for statins are an anti-inflammatory agent in patients with bronchiectasis. |
ADAM T HILL; | 2010-11-01 |
| 277 | A Randomised Controlled Trial of Atorvastatin As An Anti-Inflammatory Agent in Non-Cystic Fibrosis Bronchiectasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators hypothesise that long term statin treatment will improve patients’ symptoms through its anti-inflammatory effect. The beneficial effects on patient symptoms (cough, sputum volume, bacterial load, airway function, exercise tolerance, exacerbation frequency and health related quality of life) will be consequent on reduced neutrophilic airways inflammation. |
ADAM T HILL; | 2010-11-01 |
| 278 | Detection, Education, Research and Decolonization Without Isolation in Long-term Care to Control(DERAIL)MRSA PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Our hypothesis for the DERAIL MRSA program is that one can safely remove the colonization risk from nearly all residents (patients) in a way that does not interfere with the desired life-style for persons in these facilities and thereby reduce the risk of infection and lower the cost of care by avoiding preventable disease. |
LANCE R PETERSON; | 2010-10-01 |
| 279 | Randomized, Dose Ranging, Active Controlled Efficacy and Safety Evaluation of PMX-30063 As Initial Treatment for Acute Bacterial Skin and Skin Structure Infections (ABSSSI) Caused By Staphylococcus Aureus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study investigates the safety and efficacy of PMX-30063 in patients treated for acute bacterial skin and skin-structure infection (ABSSSI). |
POLYMEDIX | 2010-10-01 |
| 280 | Nurse-initiated Cryotherapy Intervention for Docetaxel-induced Nail Toxicities: Case-control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Between 30% and 88% of chemotherapy patients receiving docetaxel experience side effects of the hand ranging from skin and nail disfigurement, blistering, desquamation, pain, infection, and impaired treatment-related quality of life and function. Preliminary data indicate that nurse-initiated cryotherapy during treatment may lower the incidence and severity of these side effects, but several issues should be addressed before this intervention is implemented in hospital settings. These include more rigorous study design, larger sampling frames, and consideration of infection control concerns. This study will address these issues, thereby rigorously evaluating the safety and efficacy of nurse-initiated cryotherapy at Princess Alexandra Hospital. |
ALEXANDRA MCCARTHY; | 2010-10-01 |
| 281 | Daptomycin Use For Prophylaxis In Prosthetic Joint Surgery, A Randomized Prospective Study Comparing The Efficacy Of Daptomycin Versus Vancomycin For Peri-Operative Antibiotic Prophylaxis In MRSA Colonized Adult Patients Undergoing Primary Elective Hip, Knee or Shoulder Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the safety and effectiveness of daptomycin, an antibiotic compared to another one which is vancomycin when given around the time of joint replacement surgery. Vancomycin is recommended for perioperative prophylaxis in methicillin resistant Staphylococcus aureus (MRSA) colonized patients undergoing primary total joint arthroplasty. Daptomycin has not been recommended for this indication but it is FDA approved for treatment of MRSA blood stream and skin and soft tissue infections. Data collected during this study may support the use of daptomycin for this indication and may also be used for other research purposes that have not yet been specified. |
WAEL E SHAMS; | 2010-10-01 |
| 282 | Bovine Lactoferrin As A Natural Regimen of Selective Decontamination of The Digestive Tract in Patients With Prolonged Mechanical Ventilation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Nosocomial infection with antibiotic-resistant strains is a major threat to critical care medicine. Selective decontamination of the digestive tract (SDD) is one of the strategies to reduce ventilator associated pneumonia and sepsis in critically ill patients. Lactoferrin (LF) is a natural multifunctional protein with antimicrobial, anti-tumor, antioxidant, and immunomodulatory effects. It has been shown to inhibit the growth of a number of pathogenic bacteria including antibiotic-resistant strains, fungi and even viruses in both in vitro and in vivo studies. In a recent study, … |
CHIH-CHING YEN; | 2010-09-01 |
| 283 | A Randomised, Double-blind, Placebo-controlled, Phase IIa Pilot Study to Evaluate The Safety, Tolerability and Efficacy of Lytixar™ (LTX-109) in Patients With Uncomplicated, Gram-positive, Skin Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and tolerability of Lytixar™ applied topically to uncomplicated skin infections. Three dose levels of Lytixar™ (1%, 2% and 5%) versus placebo will be tested. |
LAJOS KEMENY; | 2010-09-01 |
| 284 | Copper Antimicrobial Research Program: Environmental and Patient Sampling For Indicator Organisms To Determine The Efficacy Of Copper To Reduce Acquisition Of Microbes From The Patient Care Environment PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: CONTEXT: Healthcare-acquired infections (HAI) cause substantial patient morbidity and mortality. Commonly touched items in the patient care environment harbor microorganisms that may contribute to HAI risk. Thus, reduction in the surface bioburden may be an effective strategy to reduce HAI. Inherent biocidal capabilities of copper surfaces offer a theoretical advantage to conventional cleaning, … |
MICHAEL G SCHMIDT; | 2010-07-01 |
| 285 | Testing Spread and Implementation of Novel MRSA-Reducing Practices PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to implement strategies for improved efficiency and waste reduction (Toyota Lean) and positive deviance, a social behavioral change process, utilizing frontline healthcare personnel to reduce infection bloodstream infection and MRSA infection in outpatient dialysis care. In two outpatient dialysis units, … |
MARK PARKER; | 2010-07-01 |
| 286 | Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus in The Outpatient Setting: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community. We hypothesize that a greater proportion of those who receive intervention will eliminate MRSA carriage compared to those who do not receive any intervention. |
JOSEPH KIM; | 2010-07-01 |
| 287 | Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) colonization and infections have been increasing in the general population, including the pediatric population. It has been reported that MRSA colonization persists for up to four years, and therefore the youngest pediatric patients, specifically those who are less than 2 years of age, have a high risk of prolonged colonization during a period of time when they are susceptible to significant skin and soft tissue infections (SSTIs) attributable to MRSA. Once prolonged colonization takes place, recurrent SSTIs are commonplace, resulting in substantial morbidity and in some cases mortality, … |
STEPHEN PELTON; | 2010-06-01 |
| 288 | Universal Screening and Decolonization Vs Standard Precautions for Control of Methicillin-resistant Staphylococcus Aureus (MRSA) in Nursing Homes: A Cluster, Randomised Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the better approach between the currently procedure (i.e. standards precautions) and a reinforced strategy to control MRSA transmission in the institutionalized population of nursing homes in Canton of Vaud, Switzerland. |
BELLINI CRISTINA; | 2010-06-01 |
| 289 | Rapid, Quantitative, PCR-Based Detection Of Staphylococcus Aureus in Burn Sepsis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if rapid early detection of the bacteria causing sepsis in burn patients improves patient outcomes. |
NAM TRAN; | 2010-05-30 |
| 290 | Evaluating Strategies to Prevent Methicillin-resistant Staphylococcus Aureus Skin and Soft Tissue Infections in Military Trainees PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This cluster-randomized prospective study will evaluate the effect of hygiene-based intervention strategies on the incidence of overall SSTI and MRSA-associated SSTI among military trainees. The proposed interventions used singly or in combination include standardized training and education, and weekly chlorhexidine showers. |
MICHAEL ELLIS; | 2010-05-01 |
| 291 | A Randomised, Double-blind, Placebo-controlled, Ascending Dose Phase I/IIa Study to Evaluate The Safety, Tolerability and Efficacy of Topical LTX-109 in Subjects Nasally Colonized With Methicillin-resistant/-Sensitive Staphylococcus Aureus (MRSA/MSSA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study conducted to evaluate the safety, local tolerability and efficacy of LTX-109(Lytixar™), a lytic peptide designed to kill bacterias quickly and efficient. LTX-109 (Lytixar™)will be applied in the anterior nares in subjects who are carriers of nasal colonies of MRSA/MSSA. The extent of systemic absorption of LTX -109 when applied to the anterior nares will be evaluated and the effect of Lytixar™ as to clear colonies of MRSA/MSSA during the the observation period and Week 2 to Week 9 after treatment. |
ANNA NILSSON; | 2010-05-01 |
| 292 | A Randomized Trial of Daily Chlorhexidine Care at The Exit Site in Peritoneal Dialysis Patients for Bacterial Decolonization and Prevention of Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chlorhexidine is used in central line dressing changes and is effective in reducing line infections. It is unclear if daily chlorhexidine care at the exit site in peritoneal dialysis (PD) patients can reduce the risk of Staphylococcus aureus (SA) colonization or exit site infection. |
E DA HOSPITAL | 2010-05-01 |
| 293 | The Causes and Interpretation of Low-level Resistance in Staphylococcus Aureus to Vancomycin Among A Network of Academic Medical Center Hospitals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The hypothesis of this investigation is that rate of isolation of resistant nosocomial pathogens can be explained by a combination of measures that include, among other things, antimicrobial drug use, infection control efforts, patient mix and antimicrobial stewardship efforts. The short term goal of this investigation is to improve our understanding of the relationships between antimicrobial stewardship program efforts (and actual antimicrobial drug use), and infection control efforts to the incidence rates of MSSA, MRSA, … |
VIRGINIA COMMONWEALTH UNIVERSITY | 2010-04-01 |
| 294 | Impact of Ambulatory Antibiotics Use on Nasal Carriage of Methicillin-resistant Staphylococci in Community Patients : The StaphMRG Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In this prospective, observational, multicentric open study, the investigators will compare the acquisition rates of methicillin-resistant staphylococci (coagulase-negative staphylococci and Staphylococcus aureus) nasal carriage in community patients receiving an ambulatory antibiotic treatment by either a β-lactam (amoxicillin-clavulanate or penicillins M), a macrolide, a synergistin or a fluoroquinolone. |
RAYMOND RUIMY; | 2010-03-01 |
| 295 | Randomized Non-inferiority Trial of 3 Versus 10 Days of Trimethoprim-Sulfamethoxazole in Community-Associated Skin Abscesses After Surgical Drainage PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine if there is a difference in treatment failures and recurrent skin infections when patients are given 3 or 10 days of antibiotics for uncomplicated skin abscesses after they have been surgically drained. |
LUCY HOLMES; | 2010-02-01 |
| 296 | Clinical Trial to Compare The Effectiveness of Two Protocols for Corporal Decolonization in Patients Colonized By MRSA (Methicillin Resistant Staphylococcus Aureus) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicenter Clinical Trial, experimental, randomized and prospective study to determine the effectiveness of two protocols addressing the Corporal Decolonization in patients colonized by Methicillin Resistant Staphylococcus Aureus (MRSA). PRIMARY END POINT The aim of this trial is to evaluate the effectiveness of the protocol Prontoderm® in the decolonization of MRSA patients, compared with the protocol of the Consensus Document and GEIH-SEIMC SEMPSPH (see attached extract from the document, Annex 7). Prontoderm ® is a Class III Medical Device with CE mark owned by B.BRAUN Medical SA, and currently available in Spain for the same indications proposed in this trial. |
RAFAEL ORTÍ; | 2010-02-01 |
| 297 | Randomized Controlled Trial of Antibiotics in The Management of Children With Community-Acquired Skin and Soft Tissue Abscess Undergoing Incision and Drainage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to better understand why children develop methicillin-resistant Staphylococcus aureus (MRSA) skin infections that require surgical drainage and whether antibiotics are helpful after the infection is drained in the operating room. |
KATHERINE BARSNESS; | 2010-02-01 |
| 298 | Use of Altabax Ointment (Retapamulin 1%) BID for 7 Days in Treatment of Secondary Infection With Staphylococcus Aureus (MRSA and MSSA) and Streptococcus Pyogenes in Atopic Dermatitis Patients – Open Label Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Skin infections may complicate the treatment of atopic dermatitis.The use of topical ointments has become very important to avoid the use of oral antibiotics. There is little supporting literature regarding the use of topical antibiotics in secondarily infected atopic dermatitis. This study will investigate the safety and effectiveness of Altabax ointment use in treating secondarily infected atopic dermatitis caused by Staphylococcus aureus and Streptococcus pyogenes. |
LEON KIRCIK; | 2010-02-01 |
| 299 | Evaluation of A Novel Solution, IrriSept, A New Delivery System, Containing A Long-acting Antimicrobial Agent for Irrigation of Skin and Soft Tissue Infections, in The Form of An Abscess in The Emergency Department: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to determine whether Irrisept can effectively prevent the progression of skin and soft tissue infections (SSTIs) as compared to treatment by the current Standard of Care. |
DAVID WEIN; | 2010-01-01 |
| 300 | A Pilot Randomized Trial to Determine The Efficacy of A Probiotic, Lactobacillus Rhamnosus for Reducing Colonization By Methicillin-resistant Staphylococcus Aureus (MRSA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the feasibility, safety and efficacy of oral probiotic, Lactobacillus rhamnosus versus oral placebo for reducing colonization by MRSA. |
NASIA SAFDAR; | 2010-01-01 |
| 301 | The Effect of Wound Irrigation With Irrisept Delivery System on Abscess Healing in Patients Presenting to The Emergency Department PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to evaluate the safety and effectiveness of Irrisept compared to standard of care treatment of skin and soft tissue infections in the form of abscesses. |
RICHARD PETRIK; | 2010-01-01 |
| 302 | Antimicrobial Drug Use and Resistant Staphylococcus Aureus in A Network of Academic Medical Center Hospitals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this investigation is to study the relationships between antimicrobial stewardship program efforts, antimicrobial drug use, and infection control efforts to the incidence rates of hospital acquired infections with Staphylococcus aureus in a sample of US academic medical center hospitals. |
RON E POLK; | 2010-01-01 |
| 303 | A Single Center, Double-Blind, Randomized, Placebo-Controlled Study Evaluating The Efficacy of Bio-K+ Cl-1285® In The Nasal Decolonization of Methicillin Resistant Staphylococcus Aureus (MRSA) Carrier Patients Related Papers Related Patents Related Grants Related Experts View Highlight: Trial Objectives: Primary objective: – To evaluate the efficacy of Bio-K+CL1285® in patients with Methicillin-Resistant S. aureus (MRSA) nasal colonization by comparing the MRSA decolonization following either Bio-K+CL1285® or placebo treatment. Secondary objective: – To evaluate the safety profile of Bio-K+CL1285®. |
PIERRE-JEAN PM MAZIADE; | 2010-01-01 |
| 304 | Risk of Methicillin-resistant S.Aureus (MRSA) Infections in MRSA Carrier Under Introduction of Rapid MRSA Screening PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was designed to evaluate the effect of a targeted preoperative Methicillin-resistant Staphylococcus aureus (MRSA) detection by polymerase chain reaction (PCR) on either endogenous or exogenous postoperative MRSA infections in a high risk population undergoing gastroenterological surgery. The primary endpoint was to investigate whether the potentially high incidence of MRSA infections in patients with MRSA nasal colonization before surgery can be prevented with a PCR-based strategy. The second endpoint was to investigate the impact of acquisition of MRSA colonization after surgery on the occurrence of MRSA infections. Investigators hypothesize that postoperative MRSA infection is prevented by a targeted screening strategy in preoperative MRSA carrier, and there is limited effect in patients with postoperative MRSA acquisition. |
CHIKARA TASHIRO; | 2009-11-01 |
| 305 | A Randomized, Double-blind, Placebo-Controlled, Ascending Single-Dose Safety, Tolerability, and Pharmacokinetics Study of EDP-322 in Healthy Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a randomized, double-blind, placebo-controlled, ascending single dose safety, tolerability, and pharmacokinetic study of orally administered EDP-322. This study was conducted at a single site. EDP-322 has a benefit to risk profile that supports testing in target patient populations. |
THOMAS L HUNT; | 2009-10-05 |
| 306 | Management By Primary Care Clinicians of Patients Suspected of Having Community-Acquired, Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Infections PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to further the investigators’ understanding of community acquired methicillin-resistant Staph Aureus (CA-MRSA) and treatment of it by developing real-world sustainable strategies consistent with existing guidelines on treatment of CA-MRSA from the Centers for Disease Control and Prevention (CDC) and test these strategies in busy primary care settings. |
DAVID R WEST; | 2009-10-01 |
| 307 | Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant Staphylococcus aureus (MRSA) in intensive care units. The three strategies to be evaluated are: – screening on admission followed by isolation of MRSA+ patients – screening on admission followed by isolation and decolonization of MRSA+ patients – … |
RICHARD PLATT; | 2009-09-01 |
| 308 | Epidemiology and Prevention of MRSA Transmission in The Community PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this project is to elucidate the epidemiology of MRSA transmission in the community and test an intervention to prevent MRSA transmission in this setting. |
EBBING LAUTENBACH; | 2009-09-01 |
| 309 | Prospective Study Into The Performance of The MicroPhage S. Aureus/MSSA/MRSA Test Direct From Blood Culture Positives PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Direct in-vitro identification of S. aureus, methicillin-sensitive S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA) from positive blood cultures by MicroPhage’s bacteriophage-based diagnostic platform, two gold-standard reference methods, and two predicate devices with similar indications for use. |
THOMAS KIRN; | 2009-08-01 |
| 310 | A Phase 2, Randomized, Double-blind, Multi-center Study to Evaluate The Safety and Efficacy of CEM-102 Compared to Linezolid in The Treatment of Acute Bacterial Skin Structure Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the safety and efficacy of CEM-102 compared to Linezolid in the treatment of acute bacterial skin structure infections (ABSSIs). |
ARREVUS | 2009-08-01 |
| 311 | Detection of Methicillin Resistant Staphylococcus Aureus Colonization Using The ZNose®, An Ultra-fast Gas Chromatograph PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The zNose® MRSA test is a non-invasive breath test for markers of Staphylococcus aureus, which may predict the probability of bacterial organisms in the anterior nares, throat and respiratory tract, wounds, and anus and therefore be able to replace or supplement current active Methicillin Resistant Staphylococcus Aureus (MRSA) surveillance efforts. It consists of: – A collection apparatus for collection of volatile compounds from suspected infection sites onto a sorbent trap or Tedlar bag, as well as for the collection of a separate sample of room air. – … |
CHRIS LANDON; | 2009-08-01 |
| 312 | Treatment of Patients Colonized With Methicillin-Resistant Staphylococcus Aureus Prior to Bone and Joint Surgery (TOPS-MRSA) Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators anticipate that utilization of retapamulin preoperatively will eliminate MRSA colonization among patients who are colonized in their nares. |
BAY PINES VA HEALTHCARE SYSTEM | 2009-08-01 |
| 313 | Evaluation of The Efficacy and Safety of Fosfomycin Plus Imipenem for The Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study evaluates the efficacy and safety of fosfomycin and imipenem for the treatment of methicillin-resistant staphyloccocus aureus infective endocarditis in comparison to vancomycin, the standard therapy. |
JUAN A. ARNAIZ; | 2009-07-01 |
| 314 | Comparison of Elution Swab (ESwab) and Amies Transport Swabs for Screening Patients for Methicillin Resistant Staphylococcus Aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) Colonization PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1.To assess whether the Elution swab (ESwab) is superior to Amies transport swabs for the detection of Methicillin Resistant Staphylococcus aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) in colonized patients and to determine whether nasal cultures alone is sufficient for detection of MRSA isolates in hospitalized patients. 2.To assess patient comfort in the use of the ESwab vs. Amies Transport swab for screening patients for methicillin resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. |
CHRISTINE LEE; | 2009-07-01 |
| 315 | Relationship of Staphylococcal Colonization to Infection Related Papers Related Patents Related Grants Related Experts View Highlight: Inpatients will be prospectively have nares screened and MRSA strains collected. All clinical MRSA strains of patients will also be prospectively collected. A sensitive strain discrimination test of spa typing will be used to determine if the strains are related. Hypotheses are 1. Strain colonization durations vary and may be very short in days to weeks. 2. Colonizing strains rarely infect 3) Both 1 and 2 may be affected by the patient’s co-morbidity. |
VETERANS BIOMEDICAL RESEARCH INSTITUTE | 2009-07-01 |
| 316 | Prevention of Recurrent Infections Caused By Community-Acquired Staphylococcus in Children 3 Months to 18 Years PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to determine if adding bleach baths to routine ways for prevention of Staph infections is helpful. The amount added is a very weak amount. This would provide a relatively inexpensive method to help prevent recurrent skin infections caused by the Staph germ. The investigators will also be studying how often Staphylococcus aureus lives in the nose, throat, and groin area. |
SHELDON KAPLAN; | 2009-06-01 |
| 317 | The Incidence of Methicillin Resistant Staphylococcus Aureus (MRSA) Nasal Carriage Among Resident Physicians PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One hundred new residents will be recruited prior to the start of residency and followed prospectively for a year. Monthly nasal swabs will be performed to identify colonization with methicillin resistant staphylococcus aureus (MRSA).The proportion of study subjects colonized with MRSA at the end of 1 year will be calculated. |
GARY KINASEWITZ; | 2009-06-01 |
| 318 | Host Factors in Invasive and Recurrent Staphylococcus Aureus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The incidence of community-associated (CA) staphylococcal infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA), has increased dramatically in recent years. Although the majority of these infections are limited to the skin and soft tissue and thus not life threatening, the number of invasive cases in otherwise healthy individuals is increasing and some are fatal. As a first step toward understanding pathogenesis, there has been significant focus on elucidating the key CA-MRSA virulence factors. The relative significance of these factors is still being delineated. By comparison, … |
STEVEN M HOLLAND; | 2009-05-28 |
| 319 | Prevalence of Methicillin-resistant Staphylococcus Aureus (MRSA) in A Medical Center and Efficacy of Altabax in Clearing MRSA Nasal Colonization Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine whether Altabax (retapamulin ointment, 1%) is effective in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization. The hypothesis is that the prevalence of MRSA increases as a function of increasing clinical exposure and that the topical antibiotic Altabax is efficacious in clearing MRSA nasal colonization. The prevalence of MRSA nasal colonization among Tulane University medical students and residents and physicians of Tulane Medical Center and Ochsner Medical Center will be investigated. A total of 300 subjects will be recruited for the study. After giving informed consent, … |
RUSSELL W STEELE; | 2009-05-01 |
| 320 | The Use of Adjuvant Antibiotic Therapy After Incision and Drainage for Pediatric Abscess: A Prospective, Randomized, Double-blinded, Placebo-Controlled Trial Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Skin abscesses are a growing problem in the general pediatric population around the world. While the standard treatment for an abscess/boil is incision and drainage, many physicians also prescribe antibiotics, despite the lack of evidence that antibiotics are necessary to help the wound heal. The purpose of this research study is to determine whether antibiotics are necessary after incision and drainage of a skin abscess in children. This is an important question because medical evidence has shown that using antibiotics when they are not needed has contributed to the increase of bacterial antibiotic resistance. In fact, … |
THOMAS PRANIKOFF; | 2009-05-01 |
| 321 | Strategies Using Off-Patent Antibiotics for Methicillin-Resistant Staphylococcus Aureus (STOP MRSA) – A Phase IIB, Multi-Center, Randomized, Double-Blind Clinical Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the optimal outpatient treatment strategy of uncomplicated skin and soft tissue infection (SSTI) in areas of the United States where the prevalence of Community-Acquired Methicillin-Resistant Staphylococcus (S.) aureus (CA-MRSA) is high. Infection with the S. aureus bacteria that is resistant to antibiotics is a cause of SSTIs. Three oral antibiotics will be tested for off patent treatment. Patients will receive Trimethoprim/Sulfamethoxazole (TMP/SMX), placebo (substance containing no medication), clindamycin, or cephalexin or some combination of these. The study population will include 2,235 volunteers, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2009-04-01 |
| 322 | Randomized, Double-Blind Trial of Clindamycin, Trimethoprim-Sulfamethoxazole, or Placebo for Uncomplicated Skin and Soft Tissue Infections Caused By Community-Associated Methicillin-Resistant Staphylococcus Aureus PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to evaluate 2 different antibiotics, drugs that fight bacteria, [clindamycin (CLINDA) and trimethoprim-sulfamethoxazole (TMP-SMX)] and wound care for the outpatient management of uncomplicated skin and soft tissue infections (uSSTIs) in children and adults. The study will occur in areas where community associated methicillin-resistant Staphylococcus (S.) aureus are common. S. aureus is a type of bacteria. A total of 1310 volunteers, greater than or equal to 6 months of age and adults 85 years or younger, non-immunocompromised, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2009-04-01 |
| 323 | A Randomized, Double-Blind, Double Dummy, Comparative, Multicenter Study to Assess The Safety and Efficacy of Topical Retapamulin Ointment, 1%, Versus Oral Linezolid in The Treatment of Secondarily-Infected Traumatic Lesions and Impetigo Due to Methicillin-Resistant Staphylococcus Aureus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to provide further evidence of the clinical and bacteriological efficacy of retapamulin in the treatment of subjects with SITL or impetigo due to MRSA. Subjects aged 2 months and older will be treated with either topical retapamulin for 5 days or oral linezolid for 10 days. The primary endpoint is the clinical response at follow-up (7-9 days after the end of therapy) in subjects who have a MRSA infection at baseline. The primary population is the per-protocol MRSA population. It is anticipated that approximately 500 subjects may be enrolled in order to obtain approximately 105 subjects who have a baseline MRSA infection. |
STIEFEL A GSK COMPANY | 2009-04-01 |
| 324 | Immunologic Predisposition of HIV Patients to Develop Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization and Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the role of T helper 17 cells (Th17) in the pathogenesis of MRSA infections. |
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE | 2009-03-01 |
| 325 | Two-Center Intervention Study to Evaluate The Impact of Rapid Molecular Screening on Nosocomial Transmission of Methicillin-Resistant Staphylococcus Aureus (MRSA) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of a novel PCR-based laboratory test for rapid detection of MRSA carriers to prevent transmission of MRSA in the Belgian acute care hospital setting. |
MARC J STRUELENS; | 2009-02-01 |
| 326 | Pilot Study To Determine The Underlying Mechanisms For Infection And Colonization By Staphylococcus Aureus Of The Skin Of Atopic Dermatitis Subjects With And Without A History Of Eczema Herpeticum (ADVN MRSA 10) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphylococcus aureus (S.aureus) is a bacterium that causes many painful skin and soft tissue conditions, such as scalded-skin syndrome, boils, or impetigo. Serious cases may result in deadly complications but S.aureus can usually be treated successfully with antibiotics. There are, however, certain strains which cannot be treated with standard antibiotics. Methicillin-resistant staphylococcus aureus (MRSA) is one such strain. MRSA is increasingly being seen in both hospital and community settings, making it a serious public health issue. People with Atopic Dermatitis (AD), particularly those with a history of Eczema Herpeticum (EH), … |
DONALD LEUNG; | 2009-02-01 |
| 327 | A Phase-IIa, Double-blind, Randomized, Controlled Study on The Tolerability and Early Efficacy of HLF1-11 in Hospitalized Patients With Bacteremia Due to Staphylococcus Epidermidis Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to establish the tolerability of treatment with human lactoferrin 1-11 peptide (hLF1-11) administered intravenously as a single dose given for 10 consecutive days, to patients with bacteremia due to staphylococcus epidermidis. |
P.E. VERWEIJ; | 2009-02-01 |
| 328 | MRSA Colonization and Control in The Dallas County Jail PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this 3-year project is to control the spread of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in the Dallas County Jail. CA-MRSA is a bacterium spreading rapidly through healthy populations and becoming an epidemic in many regions of the U.S. Many people in the community are asymptomatically colonized by MRSA. There have been outbreaks of MRSA infections at prisons and jails. We will study the spread of MRSA in the jail to better understand how the bacteria are transmitted from person to person there and how we can prevent their transmission. All detainees asked to participate must give informed consent to do so; their privacy will be carefully protected. Detainees with a history of allergy to CHG will be excluded. Seventeen objects in the jail will be sampled for contamination with MRSA. Bacteria will be collected from all cultures obtained from patients with bacterial skin infections for 18 months in a part of the jail in order to determine how frequently these infections are caused by MRSA relative to other bacteria. A group of about 1500 adult detainees will be tested for colonization with MRSA in order to determine how commonly detainees carry the bacterium. A cluster-randomized 6-month study will be undertaken among these detainees and those who take their places when they leave the jail to determine if chlorhexidine (CHG)-containing disposable wash cloths for skin cleaning can decrease the prevalence of MRSA skin or nose colonization. Detainees receiving CHG cloths (about 500 detainees) will be compared to detainees receiving water-soaked cloths for skin cleaning (about 500 detainees) or no intervention (about 500 detainees). The primary outcome will be a difference in average colonization prevalence in detention tanks, which are discrete detention units housing detainees, comparing the usual care to the CHG-exposed tanks after 6 months of CHG cloth use. A secondary outcome will be a decrease in skin infections from any cause in the tanks receiving CHG compared with usual care. All of the MRSA isolates and a sample of the S. aureus isolates susceptible to methicillin from specimens colonizing or infecting detainees, as well as those contaminating surfaces and objects in the jail will be tested genetically in order to determine which strains of MRSA are present in the jail. This study may identify ways to stop the spread of MRSA among people in jails and prisons, as well as other places. |
ROBERT S DAUM; | 2009-01-01 |
| 329 | Randomized Clinical Trial to Compare A Regimen of Trimethoprim-sulfamethoxazole (TMP-SMX) Plus Rifampicin With A Regimen of Linezolid in The Treatment of Infections Caused By Methicillin-resistant Staphylococcus Aureus (MRSA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: MRSA infections often require systemic antibiotic therapy and represent an important healthcare burden. Currently available treatment options are either only available in parenteral form (vancomycin) or expensive (linezolid). Thus, there is an urgent, unmet need to better investigate in-expensive but highly active alternatives to currently recommended standard treatment options. The purpose of the proposed study is to test the hypothesis that a combination of TMP-SMX and rifampicin is not inferior to linezolid for treatment of MRSA infections. |
STEPHEN HARBARTH; | 2009-01-01 |
| 330 | The Effects of Linezolid and Vancomycin on Inflammation and Cellular Signaling Vents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We will determine if linezolid inhibits cellular activation and production of pro-inflammatory cytokines, providing mechanistic rationale for its clinical efficacy and the justification for further investigations in S. Aureus sepsis. |
GUY ZIMMERMAN; | 2009-01-01 |
| 331 | A Clinical Trial on The Reduction of Bacteria (Including MRSA) in MRSA Positive Ulcers and Lesions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if gaseous nitric oxide is effective in the treatement of bacteria in MRSA positive ulcers |
NITRIC BIOTHERAPEUTICS | 2009-01-01 |
| 332 | A Phase II Trial on The Reduction of Methicillin Resistant Staphylococcus Aureus in MRSA Positive Ulcers Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine if topically applied nitric oxide gas is effective in reducing the quantity of bacteria (including MRSA)in a wound. |
KEITH HARDING; | 2009-01-01 |
| 333 | Multicenter, Retrospective, Observational Study to Evaluate Clinical and Economic Outcomes of Patients With MRSA Hospital-Acquired Pneumonia Treated With Linezolid Or Vancomycin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to review the local management of patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia treated with vancomycin or linezolid with the goal to define if any difference exists among these antimicrobials in regard to clinical and economic outcomes. |
PFIZER | 2008-11-01 |
| 334 | Mastering Hospital Antimicrobial Resistance and Its Spread Into The Community- The Role of Healthcare Workers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Medical staff will be screened for MRSA and ESBL (including: doctors, nurses, nurse aids, physical therapists, dietitians, Janitors and other medical staff). PURPOSE: To define the carriage of, and risk factors for carriage of resistant organisms among healthcare employees of carriers of resistant bacteria. To define activities of healthcare employees who likely to lead to dissemination of resistant bacteria in rehabilitation centers. |
YEHUDA CARMELI; | 2008-10-01 |
| 335 | Mastering Hospital Antimicrobial Resistance and Its Spread Into The Community:the Role of Family Members and Caregivers in Dissemination of MDR in Rehabilitation Centers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Detailed activity: – Family members and caregivers of carrier residents will be screened for ESBL and MRSA. Screening will be performed by obtaining nares and perirectal cultures. Nares cultures will be obtained by ward staff or research personnel who are experienced in performing this activity: a moisture swab will be applied gently to the distal part of both nares. Perirectal cultures, will be taken by swab, who will be applied to the perirectal area, either by staff as mentioned above, or will be given to the participants to perform by himself (with explanation on how to perform it). – … |
YEHUDA CARMELI; | 2008-10-01 |
| 336 | A Phase 2 Multicenter, Randomized, Double-blinded, Study to Describe The Safety, Efficacy, and Pharmacokinetics of Daptomycin 10 Mg/kg/Day and Vancomycin for The Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goals of this study are to compare the safety and efficacy of daptomycin monotherapy 10 mg/kg/day and vancomycin monotherapy dosed to achieve vancomycin trough levels of 15 to 20 μg/mL for the treatment of methicillin-resistant S. aureus bacteremia (MRSA), including right-sided infective endocarditis (RIE). |
CUBIST PHARMACEUTICALS | 2008-09-17 |
| 337 | Prospective Evaluation Of Protected Alveolar Lavage (PAL) Staphylococcus Aurues Resistance Patterns PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the prevalence of MRSA isolates with marginal susceptibility to vancomycin or heteroresistance. |
ANDREW C. BERNARD; | 2008-09-01 |
| 338 | A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused By MRSA PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study investigates the efficacy and safety of MK-3009 in participants with skin infections, septicemia and right-sided infective endocarditis (RIE) caused by methicillin-resistant Staphylococcus aureus (MRSA). |
MERCK SHARP & DOHME | 2008-09-01 |
| 339 | A Phase IV Pharmacovigilance, Post-Authorization Clinical Trial To Evaluate And Assess The Safety Of Tigecycline In The Approved Indications In The Usual Health Care Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to evaluate the safety of tigecycline in patients with complicated intra-abdominal infections (cIAI) and complicated skin and soft tissue infections (cSSTI) under real practice in the usual hospital setting and patients’ conditions, in order to assess the real incidence of adverse events related with tigecycline in these patients. |
PFIZER | 2008-08-01 |
| 340 | Randomized Controlled Trial of Chlorhexidine Gluconate, Intranasal Mupirocin, Rifampin and Doxycycline Versus Chlorhexidine Gluconate and Intranasal Mupirocin Alone for The Eradication of Methicillin-resistant Staphylococcus Aureus Among An Ambulatory Patient Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: MRSA decolonization may reduce the risk of subsequent MRSA infection and further transmission. A recent randomized controlled trial demonstrated that systemic decolonization may be safe and effective among hospitalized patients when compared to no treatment. As a large number of the investigators patients require re-admission and further transmission may take place in the community, the investigators are comparing the standard decolonization protocol for MRSA eradication to the systemic decolonization protocol among an ambulatory population. Standard decolonization protocols, which use only topical agents, … |
DUNCAN WEBSTER; | 2008-08-01 |
| 341 | Kerlix AMD Gauze Study In A Burn Trauma Unit and Its Effect on Healthcare Associated Infections in Burn Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether Kerlix AMD gauze will decrease the incidence of healthcare associated infections in burn patients. Kerlix AMD gauze will be applied to all patients with open wounds admitted to the burn unit during the prospective portion of the study. All consenting patients will be assessed for hospital associated infections and outcomes. We hypothesis that burn patients will have a decreased number of hospital associated infections compared to historical controls. |
LUCY A WIBBENMEYER; | 2008-08-01 |
| 342 | Primary Investigation Into The Performance of The MicroPhage S. Aureus / MSSA / MRSA Test Direct From Blood Culture PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In-vitro identification of S. aureus, methicillin-sensitive S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA) from positive blood cultures by MicroPhage’s bacteriophage-based diagnostic platform. |
J D SMITH; | 2008-07-01 |
| 343 | Household Vs. Individual Approach to Decolonization of Community-acquired Methicillin-resistant Staphylococcus Aureus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether measures to eliminate the Staph germ from the skin of the index patient (with a special ointment and soap) are more effective when performed by everyone in the household rather than the patient alone, and whether these methods are effective in preventing future Staph infections. The investigators hypothesize that there will be a greater number of households who are successful in eradicating the staph germ from the index patient when all members of the household participate than households where only the index patient is treated. |
STEPHANIE A. FRITZ; | 2008-07-01 |
| 344 | Epidemiology of Extended-spectrum ß-lactamase (ESBL)-Producing Enteric Gram-negative Bacilli in Swiss Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: The aim of the study is to determine the molecular epidemiology and genetic variability of ESBL-producing enterobacteriaceae (E-ESBL) among children in Switzerland and to estimate the associated clinical burden of disease. The investigators’ hypotheses are: 1. The genetic variability (and especially the distribution of strains harbouring the CTX-M genes) among children is similar to that observed in adults; 2. The overall burden of disease is still low in Switzerland compared to neighbouring countries. However, treatment of severe E-ESBL infections is challenging; … |
UNIVERSITY HOSPITAL GENEVA | 2008-07-01 |
| 345 | Emergency Bedside Ultrasound for The Evaluation of Soft Tissue Infections in The Pediatric Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if soft tissue infections in pediatric patients can be more accurately diagnosed (i.e. the presence of a drainable abscess) with the addition of bedside ultrasound to the clinical examination compared to the clinical examination alone. |
ELIZABETH ALPERN; | 2008-07-01 |
| 346 | Prevalence of MRSA in Skin and Soft Tissue Infections in Two Ontario Emergency Departments PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphylococcus aureus is the most common bacteria responsible for skin, bone, and muscle infections. Recent studies from the United States have suggested that a type of this bacterium called methicillin resistant S. aureus (MRSA) has become dramatically more common, especially the community strain. However, Canadian data is still largely lacking. This study aims to determine the prevalence of community acquired (CA) MRSA among patients presenting with skin and soft tissue infections to the Urgent Care Center and Emergency Departments in London, Ontario. This will be determined by taking swabs at enrollment from patient’s noses, throats, … |
CHRISTOPHER MB FERNANDES; | 2008-07-01 |
| 347 | Prospective Randomized Double Blind, Placebo-Controlled Trial of Septra for Uncomplicated Skin Abscesses in Patients at Risk for Community Acquired Methicillin-Resistant Staphylococcus Aureus Infection on 30 Day Recurrence Rates PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients will be enrolled in a multi-center study (Wilford Hall Medical Center and Brooke Army Medical Center) to prospectively evaluate outcome after treatment for an uncomplicated skin abscess. |
GILLIAN SCHMITZ; | 2008-07-01 |
| 348 | Mastering Hospital Antibiotic Resistance, A Cluster Randomized Intervention Study in Intensive Care Units Throughout Europe (Work Package 3) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Colonization of patients with Antimicrobial Resistant Bacteria (AMRB) like Methicillin Resistant Staphylococcus Aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Extended-Spectrum Beta-Lactamases (ESBL) enterobacteriaceae leads to infections; and ultimately to adverse outcomes (eg prolonged hospital stay, death). This is an urgent problem in Europe, especially in Intensive Care Units (ICUs). In this trial, colonization of patients with these AMRB will be assessed in the baseline period (6m). In phase 2 the effect of a Hygiene Improvement Program, including Chlorhexidine body washings and a Hand Hygiene training program, … |
MJM BONTEN; | 2008-06-01 |
| 349 | Cost-Effectiveness of Chlorhexidine Bathing Vs. Active Surveillance Cultures to Prevent Acquisition of Methicillin-resistant Staphylococcus Aureus and Other Hospital-Acquired Infections: A Pilot Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot study in our medical intensive care unit will evaluate the clinical and cost-effectiveness of an active surveillance program for methicillin-resistant Staphylococcus aureus (MRSA), compared to routine daily bathing with chlorhexidine gluconate (CHG)-impregnated cloths. Outcomes include rate of MRSA acquisition, and of other hospital-acquired infections (e.g., catheter-associated bloodstream infections). |
MARCI DREES; | 2008-06-01 |
| 350 | Prospective Randomized Controlled Trial of Antibiotic Treatment for Uncomplicated Skin Abscess in Patients at Risk for Community Acquired Methicillin-Resistant Staphylococcus Aureus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients will be enrolled in a multi-center study to prospectively evaluate outcome after treatment for an uncomplicated skin abscess. All patients will receive incision and drainage and wound cultures. Patients will then be randomized to 1)no antibiotic or 2) bacterium double strength (DS) (800/160) two tablets per oral (PO) twice a day x 7 days. This is the dose recommended for treating skin and soft tissue infections. (Ellis et al. Current Opinion in Infectious Diseases. 18(6):496-501, … |
GILLIAN SCHMITZ; | 2008-06-01 |
| 351 | An Interventional Study to Evaluate The Impact of Two Innovative Strategies in Preventing Nosocomial MRSA Infection in Surgical Patients PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level. A total of ten adult surgical departments with at least 3 surgical subspecialties each will participate in the study. Sites of the study are located in 9 countries (UK, France, Spain, Germany, Switzerland, Italy, Serbia, … |
STEPHEN HARBARTH; | 2008-05-01 |
| 352 | A Phase II Randomized, Observer-Blind, Multi-Center Study to Evaluate The Safety, Potential Efficacy, and Pharmacokinetics of Two Dosing Regimens of Intravenous PZ-601 and Standard of Care in The Treatment of Complicated Skin and Skin Structure Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the potential effect and safety of two different doses of PZ-601 and to compare this with another antibiotic that is approved by the US Food and Drug Administration (also known as FDA) to treat adults with skin and skin structure infections. |
PROTEZ PHARMACEUTICALS | 2008-05-01 |
| 353 | Changes in Adherence to Diet, Treatment and Medication in The Cystic Fibrosis Patient As A Result of Participation in A Simulation Game PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Nonadherence to treatment regimes among patients with cystic fibrosis (CF) is well documented in the literature. Unfortunately, few interventions have been successful at improving adherence rates in this patient population. Within the pediatric population, specifically adolescents, … |
CRAIG A. FRIESEN; | 2008-05-01 |
| 354 | GeneXpert in Studying Staphylococcus Aureus Infections at The Michael E. DeBakey Medical Center, Houston, Texas PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether the Cepheid GeneXpert system accurately detects Methicillin-Resistant and -Susceptible Staphylococcus aureus in blood cultures and wound swabs. |
DANIEL M MUSHER; | 2008-04-01 |
| 355 | Physician Dress Code And Microbial Colonization Of The White Coat: Does Physician Dress Code Alter Bacterial Colonization Rate On The Clothing Of Physicians? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Governmental agencies in the United Kingdom and Scotland have recently instituted guidelines banning physicians’ white coats and wearing of long-sleeved garments to decrease hospital transmission of bacteria. The purpose of this study is to compare the bacterial contamination of physicians’ white coats with that of newly laundered, standardized short-sleeved uniforms after an eight-hour workday and to determine the rate at which bacterial contamination of the uniform ensues. Our hypothesis was that the physician white coat would have more bacterial contamination at the end of the work day. |
MARISHA BURDEN; | 2008-04-01 |
| 356 | Microbiology and Clinical Outcome of Community Acquired Pneumonia and Health-Care-Associated Pneumonia in Taiwan: A Multi-Center Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. BACKGROUND Pneumonia occurring outside of the hospital setting is regarded as community acquired pneumonia. However, pneumonia occurring in non-hospital long-term care facilities constituted a distinct type of pneumonia from CAP. Kollef et al has justified health care associated pneumonia (HCAP) as a new category of pneumonia [1]. The HCAP patients are associated with severe disease, higher mortality rate, and greater length of stay and increased cost [1]. HCAP are often at risk for multi-drug resistant bacterial pathogens such as Pseudomonas aeruginosa, extended-spectrum beta-lactamase Klebsiella pneumoniae, Acinetobacter baumannii, … |
CHIEH-LIANG WU; | 2008-03-01 |
| 357 | Aquacel Vs. Iodoform Gauze for Filling Abscess Cavity Following Incision and Drainage: A Randomized Control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares Aquacel against routine Iodoform packing for packing abscess cavities after incision and drainage. It is hypothesized that Aquacel will produce speedier healing of the abscess. |
MADHUMITA SINHA; | 2008-03-01 |
| 358 | Comparison of Decolonization of MRSA Using Theraworx Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine treatment method of Methicillin-resistant Staphylococcus aureus (MRSA) decolonization in patients. |
ROGER E HUCKFELDT; | 2008-03-01 |
| 359 | Evaluation of The Prevalence of Methicillin Resistant Staphylococcus Aureus Colonization in Pre-Surgical Patients and Post-Operative Infection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the prevalence of pre-surgical patients who are MRSA carriers. From an evidence-based practice perspective, findings from this study can be considered in the evaluation of the hospital SOP mandating pre-surgical MRSA screening requirements for patients with scheduled surgeries. The central hypothesis to be addressed in this study is whether the MRSA colonization and subsequent post-operative infection are the equivalent in these populations. |
CYNTHIA HACK; | 2008-02-01 |
| 360 | A Prospective Cohort Pilot Study of The Clinical and Molecular Epidemiology of Staphylococcus Aureus in Pregnant Women at The Time of Group B Streptococcal Screening in A Large Urban Medical Center in Chicago, IL USA PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen of the 21st century whose incidence as a cause of local and invasive infections has significantly increased, … |
TINA Q. TAN; | 2008-02-01 |
| 361 | A Pilot Study of Daptomycin for Antimicrobial Prophylaxis in Patients Undergoing Cardiac Valve Replacement and Coronary Artery Bypass Grafting (CABG) Who Are at Increased Risk for Infection Due to Methicillin-resistant Staphylococcus Aureus (MRSA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goals of the study are to evaluate the feasibility of using daptomycin as a prophylactic antimicrobial agent in patients undergoing cardiac surgery, to determine the rates of surgical site infection, and to evaluate the occurrence of adverse events. |
KEITH S KAYE; | 2008-01-01 |
| 362 | Population Pharmacokinetics of Linezolid in Intensive Care Units Patients Treated for Methicillin-Resistant Staphylococcus Aureus (MRSA) Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Linezolid is the first of a new class of antibacterial drugs, the oxazolidinones. It has a specific inhibitory activity against Gram positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Dosage of 600 mg discontinuous administration twice a day was about studies in safety volunteers. The intensive care units patients, with mechanical ventilation, and with severe sepsis, represent highly heterogeneous population responsible of hight variability in pharmacokinetics parameters (augmentation in total volume of distribution, modification in glomerular filtration) wich can lead to antibiotic inefficacy. In a first time, … |
BERNARD GEORGES; | 2007-11-01 |
| 363 | Early Infectious Disease Consultation for Better Outcomes From Staphylococcus Aureus Bacteremia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective is to determine if early infectious disease (ID) consultation (defined as within 48 hours of a positive blood culture) will reduce mortality rates from Staphylococcus aureus bacteremia (SAB). This study will also determine if such consultations could reduce the duration of hospitalisation, recurrence and financial costs in patients with this infection. |
PAUL A TAMBYAH; | 2007-10-01 |
| 364 | Efficacy of Alcohol Hand-rubbing Covering All Hand Surfaces in Reducing Bacterial Hand Contamination of Healthcare Staff PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled trial comparing the effectiveness of three hand hygiene protocols, during routine inpatient clinical care: Protocol 1: handrubbing with alcohol covering all hand surfaces in no particular order; Protocol 2: handrubbing with alcohol using the WHO standard 7-step technique; and Protocol 3: handwashing with chlorhexidine using the WHO standard 7-step technique. The main study hypothesis is that alcohol hand-rubbing covering all hand surfaces is not less effective in reducing bacterial hand contamination of healthcare staff than alcohol hand-rubbing using 7-step technique; … |
ANGELA LP CHOW; | 2007-10-01 |
| 365 | BacLite Rapid MRSA Clinical Performance Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the performance of the 3M(TM) BacLite (TM) Rapid MRSA test system to traditional culture methods in detecting the presence of Methicillin Resistant Staphylococcus aureus (MRSA) directly from nasal samples. |
WERNER E BISCHOFF; | 2007-10-01 |
| 366 | Multicenter, Randomized, Double-Blind Study of Ceftobiprole Versus Comparators in The Treatment of Patients With Fever and Neutropenia Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety and efficacy of ceftobiprole versus a comparator in patients with fever and neutropenia |
BASILEA PHARMACEUTICA | 2007-10-01 |
| 367 | Randomized, Double-blind, Placebo-controlled Study to Evaluate The Safety, Tolerability, Pharmacokinetics (PK) and Efficacy of Retapamulin Ointment, 1% Applied Twice Daily for 3 or 5 Days to The Anterior Nares of Healthy Adult Subjects Nasally Colonized With Staphylococcus Aureus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase I/IIa randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and efficacy of Retapamulin ointment, 1% applied twice daily for 3 or 5 days to the anterior nares of healthy adult subjects who are nasally colonized with S. aureus. Approximately 57 healthy subjects who are nasal carriers of S. aureus will be enrolled and stratified in a 2:1 ratio so that at least 38 persistent carriers and 19 intermittent carriers complete the study. Each eligible subject will participate in three screening visits, a treatment period, … |
GLAXOSMITHKLINE | 2007-09-01 |
| 368 | Multicenter Evaluation of The Effectiveness of Source Control With Daily Chlorhexidine Skin Preparation in Reducing Nosocomial Infections Including MRSA and VRE PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine if daily bathing with chlorhexidine impregnated washcloths will reduce the incidence of MRSA and VRE within an Intensive Care Unit (ICU) or ward setting. |
EDWARD S WONG; | 2007-08-01 |
| 369 | Vancomycin and Daptomycin Plus Cefazolin for Preoperative Vascular Surgery Prophylaxis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study prospectively selects the patients to examine the effectiveness of the investigators’ current standard of prophylaxis prior to vascular surgery and to compare the effectiveness of vancomycin and daptomycin plus cefazolin in reducing infections in vascular surgical patients. |
PATRICK STONE; | 2007-08-01 |
| 370 | Randomized, Open-Label Study Evaluating The Safety and Rate of Bacterial Clearance of Ceftobiprole 500 Milligram Every 8 Hours Compared to Conventional Therapy in The Treatment of Hospitalized Subjects With Staphylococcus Aureus Bacteremia Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety and efficacy of ceftobiprole versus a comparator in hospitalized patients with bacteremia. |
BASILEA PHARMACEUTICA | 2007-07-19 |
| 371 | Physical Plant Design and Engineering Controls and The Prevention of Nosocomial Infections and Antibiotic Resistant Organism Colonization Events – A Proposal for A Prospective Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: With the construction of a new medical teaching ward with features designed to reduce hospital-acquired infections, we hypothesized that the design of the new ward was the major factor that contributed to the improved outcomes and designed a prospective, controlled study to examine this hypothesis. |
JOHN CONLY; | 2007-06-01 |
| 372 | Treatment With Cotrimoxazole Vs. Vancomycin for Infections Caused By Methicillin-resistant Staphylococcus Aureus: Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Methicillin-resistant Staphylococcus aureus (SA) is a major pathogen causing mainly health-care associated infections and, lately, also community acquired infections. Few treatment choices exist to treat these infections. The currently recommended antibiotics for these infections are glycopeptides (vancomycin or teicoplanin). Glycopeptide treatment hs several disadvantages. It is a last resort antibiotic family that should be reserved for the future; Vancomycin is less effective that beta-lactam drugs for SA infections susceptible to both agents; treatment can only be given intravenously; … |
MICAL PAUL; | 2007-06-01 |
| 373 | A Double-Blind, Placebo-Controlled, Randomized, Dose-Escalating Study of Single (Part A) and Multiple (Part B) Intravenous Doses of Friulimicin B in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to study the safety of single doses and multiple doses of Friulimicin B in healthy volunteers. The level of Friulimicin B will be measured in the subjects blood and urine. One part of the study will assess if Friulimicin B in the plasma of subjects has activity against bacteria. |
MICHAEL SIEBERLING; | 2007-06-01 |
| 374 | The Efficacy of SinoFresh Nasal and Sinus Care Nasal Spray in Eliminating MRSA From The Nasal Cavity Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to assess the ability of SinoFresh Nasal & Sinus Care, an FDA approved over-the-counter nasal spray, to eliminate the bacteria in your nose. |
IRSK ANDERSON; | 2007-06-01 |
| 375 | Chlorhexidine Impregnated Cloths to Prevent Skin and Soft Tissue Infections in Marine Officer Candidates: A Randomized, Double-Blind, Placebo-Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Outbreaks of skin and soft tissue infections (SSTI) related to community associated Methicillin-resistant Staphylococcus aureus (MRSA) have become increasingly common in military training units. Risk factors for MRSA related SSTI such as crowding, poor hygiene and shared equipment are often hard to avoid in a military training environment, … |
TIMOTHY J WHITMAN; | 2007-05-01 |
| 376 | Prospective Study on The Incidence, Predictors, and Characteristics of Methicillin-Resistant Staphylococcus Aureus Infections and A Randomized, Double-Blind Study on Decolonization Procedures for Prevention of MRSA Infections Among HIV-Infected Persons PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will prospectively evaluate the prevalence and incidence (over a two year period) of MRSA colonization and infection among HIV-infected military beneficiaries to determine predictors for the development of MRSA colonization and infection. This study will also investigate the utility of decolonization procedures for clearance of MRSA carriage and prevention of MRSA infections. Finally, the molecular characteristics and the antimicrobial sensitivities of isolates in this population will be determined. |
BRIAN AGAN; | 2007-05-01 |
| 377 | Carriage and Transmission of Methicillin-Resistant Staphylococcus Aureus (MRSA) in Patients Admitted to Home Care Related Papers Related Patents Related Grants Related Experts View Highlight: Methicillin resistant Staphylococcus aureus (MRSA) which is one of the principal multidrug resistant organisms found in the hospitals all over the world, has recently emerged in the community. However, for the moment (2002), … |
MARIE-HÉLÈNE NICOLAS-CHANOINE; | 2007-04-04 |
| 378 | A 2X2 Phase III Open-label Clinical Trial of Therapy for Patients with Recurrent Methicillin Resistant Staphylococcus Aureus Infections: Topical Nasal & Body Decolonization And/or Environmental Decontamination Vs. Standard of Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial tests the hypotheses that 1) body decolonization of patients with recurrent community-associated (CA) MRSA infections and their household members and 2) environmental decolonization of the patients’ households will significantly reduce the likelihood of recurrent CA-MRSA infection. |
LOREN G MILLER; | 2007-04-01 |
| 379 | The Natural History of Community-Associated Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Infections and An Evaluation of Decolonization Strategies PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the natural history of community-associated Staphylococcus aureus infections in both adult and pediatric patients by monitoring the rate of recurrent infections in those colonized with S. aureus. In addition, this study will evaluate the efficiency of commonly prescribed decolonization measures in patients presenting with S. aureus skin and soft tissue infections. |
STEPHANIE A. FRITZ; | 2007-03-01 |
| 380 | Early Administration of Bifidobacterium Bifidum to Very Low Birth Weight Infants: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the effects of early administration of probiotics on acceleration of enteral feeding, and on growth of very low birth weight infants, newborn infants with birth weight less than 1500g are administered Bifidobacterium bifidum twice a day. |
TOKYO WOMEN’S MEDICAL UNIVERSITY | 2007-03-01 |
| 381 | Cluster Randomized Controlled Trial of A Multifaceted Intervention to Improve Hand Hygiene Among Healthcare Workers PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial will evaluate the effect of a multifaceted intervention including performance feedback on adherence to hand hygiene among healthcare workers. A key component of the study is to demonstrate whether improved adherence to hand hygiene leads to a reduction in rates of infection. |
MARK B LOEB; | 2007-01-01 |
| 382 | Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sternal or mediastinal infections after heart operation occurs infrequently but carries a high cost in money, morbidity, and mortality. At our hospital, Staphylococcus species cause most of these infections and is uniformly sensitive to vancomycin. However, the relative low concentration of vancomycin in sternal bone was noted given intravenously. Topical vancomycin was therefore considered to apply on the cut edege of sternal bone before closure in patients receiving coronary artery bypass graft to evaluate the effect on reducing the infection rate of staphylococcus related mediastinitis (6). In addition, … |
FAR EASTERN MEMORIAL HOSPITAL | 2007-01-01 |
| 383 | A Multicentre, Open Label, Uncontrolled Clinical Trial to Evaluate Efficacy and Safety of Daptomycin for The Treatment of Complicated Skin and Skin-Structure Infections (cSSTI) Caused By Methicillin-resistant Staphylococcus Aureus (MRSA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the safety and efficacy of daptomycin against complicated skin and skin-structure infections in adults |
NOVARTIS | 2007-01-01 |
| 384 | Infections Caused By Enterobacteriaceae Producing Extended-Spectrum Β-Lactamases in Italy: Molecular Epidemiology, Clinical Impact, Treatment Outcome and Risk Factors PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the molecular epidemiology, clinical impact, treatment outcome and risk factors for infections caused by Enterobacteriaceae producing ESBLs in Italy in a large multicenter observational survey. SPECIFIC OBJECTIVES 1. To collect consecutive nonreplicate isolates of Enterobacteriaceae resistant to expanded-spectrum cephalosporins from clinical specimens from inpatients and outpatients. 2. To characterize the isolates for resistance phenotypes and for β-lactam resistance mechanisms. 3. To investigate the clonality of isolates. 4. To analyse the epidemiology of various resistance mechanisms/resistant clones. 5. To collect clinical and epidemiological data for patients with infections caused by the ESBL producers. 6. To analyse the epidemiology, … |
EVELINA TACCONELLI; | 2006-10-01 |
| 385 | Randomized, Multi-Center, Comparative Trial of Short-Course Empiric Antibiotic Therapy Versus Standard Antibiotic Therapy for Subjects With Pulmonary Infiltrates in The Intensive Care Unit (ICU): Impact on Antimicrobial Resistance, Superinfections, Length of ICU Stay and Hospitalization, and Mortality PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will enroll 460 subjects who have new pulmonary infiltrates during their ICU stay and who are at low risk of having pneumonia, as determined using the Clinical Pulmonary Infection Score (CPIS). The study is designed to determine whether 3 days of antibiotic treatment with meropenem (with or without coverage for MRSA) for ICU subjects diagnosed with new pulmonary infiltrates can reduce the emergence of anti-microbial-resistant organisms and the isolation of a potential pathogen compared to a standard course of antibiotic therapy (minimum of 8 days of therapy with antibiotics of the primary care team’s choosing). Subjects will be randomly placed in either the meropenem group or standard antibiotic therapy group. The study will also examine whether short-course therapy reduces hospital length of stay and hospital cost, without having a negative effect on subject morbidity and mortality. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2006-10-01 |
| 386 | Comparison of Cephalexin Versus Clindamycin in The Empiric, Outpatient Treatment of Suspected Staphylococcal Cutaneous Infections in The Era of Community-associated Methicillin-resistant Staphylococcus Aureus (CA-MRSA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). The investigators hypothesize that treatment with cephalexin, a penicillin-like antibiotic to which CA-MRSA would be expected to be resistant, does not result in poorer outcomes than treatment with clindamycin, an antibiotic to which CA-MRSA is most often susceptible. |
AARON CHEN; | 2006-09-01 |
| 387 | Randomized, Multi-Center, Comparative Trial of Short-Course Empiric Antibiotic Therapy Versus Standard Antibiotic Therapy for Subjects With Pulmonary Infiltrates in The Intensive Care Unit (ICU) Related Papers Related Patents Related Grants Related Experts View Highlight: This study will compare two treatment strategies (standard versus short-course antibiotic therapy) for preventing resistant bacterial infection in patients in the intensive care unit (ICU). ICUs are the most frequently identified source of hospital-acquired infections. This study will examine the effectiveness of 3 days of antibiotic treatment in reducing the risk of developing antimicrobial-resistant bacteria as compared with standard antibiotic therapy of at least 8 days. It will also determine whether short-course therapy can reduce the duration and costs of ICU and hospital stays, of antibiotic treatment, … |
NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER CC | 2006-08-11 |
| 388 | A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial tests the hypothesis that body decolonization of patients with recurrent community-associated (CA) MRSA infections will significantly reduce the likelihood of recurrent CA-MRSA infection. |
ALLEN RADNER; | 2006-08-01 |
| 389 | A Randomized, Double-Blind, Multicenter Study of Ceftobiprole Medocaril Versus Placebo in The Treatment of Subjects Hospitalized With Community-Acquired Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the clinical cure rate (ratio of clinically cured patients to the total number of patients) of ceftobiprole medocaril versus a comparator in the treatment of patients with community-acquired pneumonia. |
BASILEA PHARMACEUTICA | 2006-06-01 |
| 390 | A Randomized Single Blind Parallel Control Trial to Evaluate The Loading Dose Required to Achieve Therapeutic Serum Teicoplanin Concentration Timely PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether the standard dosage of teicoplanin is adequate to produce timely the trough level > 10 mg/L, which is considered to be effective in the treatment of methicillin-resistant Staphyllococcus aureus (MRSA) bacteremia. |
SHAN-CHWEN CHANG; | 2006-06-01 |
| 391 | A Prospective, Randomized Trial Comparing Vancomycin With Trimethoprim/Sulfamethoxazole for The Treatment of MRSA Osteomyelitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary question of this study is to understand if trimethoprim-sulfamethoxazole (TMP-SMX) is as effective as vancomycin for treating methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. |
TIMOTHY H. DELLITT; | 2006-05-01 |
| 392 | Retrospective Chart Review of The Outcome of Treatment for Staphylococcus Aureus Bacteremia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to review medical records at MEDVAMC in order to relate the outcome of bacteremic MRSA infection to the antibiotics selected for treatment. |
DANIEL M MUSHER; | 2006-02-01 |
| 393 | Effective Duration of Antibiotic Treatment of Community-Acquired Methicillin-Resistant Staphylococcus Aureus (MRSA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the effective duration (in days) to clinical improvement of outpatient antibiotic regimens in the treatment of superficial abscesses caused by MRSA in patients that present to the emergency department. |
BRIAN LEVINE; | 2006-02-01 |
| 394 | Vancomycin Versus Vancomycin Plus Gentamycin For Treating Bacteremic Infection Due to Methicillin-Resistant Staphylococcus Aureus (MRSA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the outcome of treatment for bacteremic MRSA infection with vancomycin alone, vancomycin plus gentamicin, vancomycin plus rifampin, and vancomycin plus gentamicin and rifampin. |
DANIEL M MUSHER; | 2006-01-01 |
| 395 | Experimental Phage Therapy of Drug-resistant Bacterial Infections, Including MRSA Infections Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this experimental therapy is to treat, with the aid of bacteriophages, patients with non-healing postoperative wounds or bone, upper respiratory tract, genital or urinary tract infections in whom extensive antibiotic therapy failed or the use of the targeted drug is contraindicated. |
ANDRZEJ GÓRSKI; | 2005-12-01 |
| 396 | Microbiologic Effect of Selective Decontamination of The Digestive Tract With Colistin, Gentamicin and Nystatin PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Selective decontamination of the digestive tract (SDD) is a prophylactic measure aimed at reducing Gram negative flora in the gut with an aim to reduce nosocomial infections such as ventilator-associated pneumonia. A recent large randomized trial in the Netherlands showed that SDD use was associated with reduced mortality in the ICU. Theoretically, SDD may select for Gram positive organisms such as MRSA or VRE. This was not observed in the Dutch study, … |
DAVID L PATERSON; | 2005-11-04 |
| 397 | A Phase 3 Randomized Double-Blind Study Of Ceftobiprole Medocaril Versus Linezolid Plus Ceftazidime In The Treatment Of Nosocomial Pneumonia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril (the water-soluble prodrug [form] of ceftobiprole) referred to as ceftobiprole versus a comparator in the treatment of patients with nosocomial pneumonia. |
BASILEA PHARMACEUTICA | 2005-11-01 |
| 398 | The Prevalence of Panton Valentine Leukocidin, Exfoliative Toxin and Agr Genotypes in Staphylococcus Aureus Nasal Colonization in Vancouver’s Eastside Community PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: We plan to compare data from 300 nasal swab in Vancouver’s Downtown Eastside taken in 2001 to data obtained in 2005. The nasal carriage rate of MRSA and the specific characteristic of each MRSA found will be analyzed. A limited amount of associated information will be obtained |
STEVE REYNOLDS; | 2005-10-01 |
| 399 | Prospective Study of Drug Resistant Pathogens Among Liver, Intestinal and Multivisceral Transplant Recipients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Infections caused by multidrug resistant bacteria have become more prevalent at many tertiary care and academic centers. These infections are associated with increased morbidity and mortality. The initial empiric antibiotic choice may not be adequate and delay in initiating appropriate therapy is a reason for poorer outcomes. Furthermore, not uncommonly the only therapeutic options available are associated with significant toxicity. This is a particular challenge for solid organ transplant recipients, … |
DAVID L PATERSON; | 2005-10-01 |
| 400 | A Phase III, Randomized, Double-Blind Study of Ceftobiprole Versus Comparator in The Treatment of Complicated Skin and Skin Structure Infections PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril versus a comparator in the treatment of patients with complicated skin and skin structure infections. The study will also characterize the safety and tolerability of treatment with ceftobiprole medocaril in patients with complicated skin and skin structure infections. |
BASILEA PHARMACEUTICA | 2005-09-01 |
| 401 | A Prospective Study of MRSA Colonization in Peripartum Women and Their Offspring PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: We hypothesize that pregnant women are at baseline risk for carrying community-acquired MRSA, but also have frequent contact with healthcare workers which may put them at risk for hospital-acquired MRSA carriage. Our study aimed to identify the colonization rate of women in active labor and whether transmission to infants may occur. |
MARGRET G REUSCH; | 2005-09-01 |
| 402 | A Prospective Implementation of An IV-oral Switch Policy to Treat Proven or Suspected Infections Due to Resistant Gram Positive Bacteria in A London Hospital Trust PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to find out whether changing the hospital policy to allow switch from glycopeptide antibiotics (given by intravenous drip), to an equally effective oral antibiotic (linezolid) will enable patients who are otherwise well enough to be discharged from hospital sooner. The secondary objectives are 1. To identify those patients who could potentially be discharged on an oral agent from those being treated with a glycopeptide, … |
KATHLEEN B BAMFORD; | 2005-09-01 |
| 403 | The Impact of Treating Staphylococcus Aureus Infection and Colonization on The Clinical Severity of Atopic Dermatitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Staphylococcus aureus (S. aureus) infection is perceived not only as a common secondary complication of atopic dermatitis (AD), but also as a culprit in the worsening of this condition. In addition, the recent development of community acquired methicillin-resistant S. aureus (CA-MRSA) has presented a new challenge to our management of AD, … |
AMY PALLER; | 2005-09-01 |
| 404 | Empiric Therapy With Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in An Area of High MRSA Prevalence: A Prospective Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: In many communities, skin and soft tissue infections (SSTI) with MRSA have become more prevalent than infections with β-lactam susceptible bacteria. This has necessitated altered empiric antimicrobial therapy of SSTI to cover MRSA. Objective: To evaluate empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient SSTI in an area of high MRSA prevalence. Design: Randomized, prospective, open-label investigation. Setting: Emergency Department of Parkland Hospital in Dallas, Texas. Patients: Adults with SSTI. Intervention: Empiric oral therapy with trimethoprim-sulfamethoxazole (160 mg/800 mg, twice daily) or doxycycline (100 mg, … |
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2005-08-01 |
| 405 | A Prospective Randomized Double-Blind Trial of A Polyhexamethylene Biguanide (PHMB) Impregnated Gauze Dressing for The Prevention of Chronic Wound Colonization With Resistant and Prevalent Microorganisms PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if a new antimicrobial gauze dressing is better than the current method of dressing open wounds with plain sterile gauze. It is hoped that the antimicrobial gauze will reduce the number of germs in the open wound and even improve the rate of healing. |
TYCO HEALTHCARE GROUP | 2005-06-01 |
| 406 | Open Label, Single Center Study to Evaluate Higher Doses of Daptomycin in The Treatment of Patients With Severe Necrotizing Skin and Soft Tissue Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Daptomycin is a new antimicrobial agent which has activity against resistant Gram positive cocci including MRSA. The phase 3 clinical trials for skin and soft tissue infections (SSTI) with Staphylococci and Streptococci have already demonstrated that daptomycin was noninferior to the comparator agent (vancomycin or beta-lactams) (10). Although this clinical trial did not include any patients with clostridial infection, there is in vitro data to support the activity of daptomycin against a variety of clostridial species(11) ( Clostridium perfringens) Therefore, for this trial we will include patients with clostridial infections with this species. Additionally, … |
DENISE RUDELL; | 2005-06-01 |
| 407 | Association of Antibiotic Measures and Control of Bacterial Resistance PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Assess efficacy of piperacillin/tazobactam in reducing the cases of colonization and infection of bacteria. |
WYETH IS NOW A WHOLLY OWNED SUBSIDIARY OF PFIZER | 2005-05-01 |
| 408 | A Phase III Randomized Double-Blind Study Of Ceftobiprole Versus Linezolid Plus Ceftazidime In The Treatment Of Nosocomial Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril (the water-soluble prodrug [form] of ceftobiprole) referred to as ceftobiprole versus a comparator in the treatment of patients with nosocomial pneumonia. |
BASILEA PHARMACEUTICA | 2005-04-01 |
| 409 | Intermittent Mupirocin to Prevent Staphylococcal Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if mupirocin 2% in polyethylene glycol (PEG) ointment [Treatment Arm] is effective in preventing moderate to severe re-infection with Staphylococcus aureus compared with treatment with polyethylene glycol (PEG) ointment [Placebo Arm]. |
SUZANNE BRADLEY; | 2005-04-01 |
| 410 | Strategies to Reduce Transmission of Antimicrobial Resistant Bacteria in Intensive Care Units (STAR*ICU) Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Outcome Measures:Incidence density of colonization with MRSA or VRE (number of new colonization events per 1000 patient days at risk) during the intervention phase. Secondary Outcome Measures:The effect of the 2 strategies on the incidence density of colonization with MRSA and VRE individually will be determined and compared descriptively. The effect of the strategies on the cumulative incidence of bacteremia caused by MRSA and VRE will be determined to assess the clinical relevance of the strategy in preventing infection. The trial will evaluate the frequency of hand hygiene and the use of gloves and gowns by healthcare workers to substantiate whether the effect of the intensive control strategy is mediated, as expected, by an increase in the use of gloves and gowns due to an increase in the number of patients cared for using Contact Precautions. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2005-03-01 |
| 411 | A Phase 3, Randomized, Double-Blind, Multinational Trial of Intravenous Telavancin Versus Vancomycin for Treatment of Complicated Gram Positive Skin and Skin Structure Infections With A Focus on Patients With Infections Due to Methicillin-resistant Staphylococcus Aureus PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Study 0018 (NCT00107978) compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin structure infections. |
G. RALPH COREY; | 2005-02-01 |
| 412 | A Phase 3, Randomized, Double-Blind, Parallel-Group, Multinational Trial of Intravenous Telavancin Versus Vancomycin for Treatment of Hospital-Acquired Pneumonia With A Focus on Patients With Infections Due to Methicillin-Resistant Staphylococcus Aureus PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Study 0015 (NCT00107952) compares the safety and effectiveness of an investigational drug, telavancin, with vancomycin for the treatment of hospital-acquired pneumonia. |
G. RALPH COREY; | 2005-02-01 |
| 413 | An Attempt to Reduce Community-Acquired Methicillin-Resistant Staphylococcus Aureus Infection in Soldiers: A Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine if applying mupirocin into soldiers noses who are colonized with methicillin-resistant Staphylococcus aureus (MRSA) will reduce infections in them and their cohort of fellow soldiers. |
MICHAEL W ELLIS; | 2005-01-01 |
| 414 | A Phase 3, Randomized, Double Blind, Multinational Trial of Intravenous Telavancin Versus Vancomycin for Treatment of Complicated Gram Positive Skin and Skin Structure Infections With A Focus on Patients With Infections Due to Methicillin-resistant Staphylococcus Aureus PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Study 0017 compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin structure infections. |
G. RALPH COREY; | 2005-01-01 |
| 415 | Colonization, Infection, and Molecular Typing of Methicillin-Resistant Staphylococcus Aureus (MRSA) in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The intent of this study is to: 1. Define the prevalence of MRSA carriage in the pediatric population in Kansas City. 2. Systematically define patient risk factors for MRSA carriage and infection. 3. Characterize the unique genetic characteristics of MRSA strains, both community acquired (CA) and healthcare associated (HCA) that are present in the different pediatric populations. |
EMILY A THORELL; | 2005-01-01 |
| 416 | Analysis of Methicillin Resistant Staphylococcus Aureus (MRSA) Obtained Through The Emergency Department in A Tertiary Care Hospital in Vancouver Canada From 2001-2005 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To analyze microbiological data from MRSA samples obtained through the emergency department from 2001-2005. There is a strong clinical suspicion that we are now seeing an outbreak of a new strain of MRSA and we plan to better characterize the Vancouver population and complete a chart review to assess specific associated factors. |
STEVE REYNOLDS; | 2005-01-01 |
| 417 | The Impact of The Use of Chlorhexidine-Based Bathing System in The Hospital to Reduce The Incidence of MRSA/VRE Infection or Colonization and Nosocomial Bloodstream Infections (BSI) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to determine if the use of daily chlorhexidine bathing would decrease the incidence of MRSA and VRE colonization and healthcare associated Bloodstream Infections (BSI) among Intensive Care Unit (ICU) patients. |
EDWARD W WONG; | 2004-11-01 |
| 418 | A Placebo Controlled, Randomized, and Blinded Study of Antibiotic Treatment of Patients With Uncomplicated Soft Tissue Infection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to determine whether antibiotic therapy is needed for patients with non-life threatening soft tissue infections. Most patients with these soft tissue infections are presently treated with antibiotics. Many of these infections resolve without proper antibiotic treatment. Treatment of patients with antibiotics after surgical drainage of an abscess may not be necessary and indiscriminate use of antibiotics may lead to colonization by drug-resistant organisms. Subsequent infection by drug resistant organisms may limit the choice of antibiotics in more complicated infections. A comparison between antibiotic treatment and no antibiotic treatment in surgically treated, … |
DAVID M YOUNG; | 2004-11-01 |
| 419 | Linezolid in The Treatment of Subjects With Complicated Skin and Soft Tissue Infections Proven to Be Due to Methicillin-Resistant Staphylococcus Aureus PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine if linezolid is superior to vancomycin in the treatment of complicated skin and soft tissue infections due to MRSA in adult subjects |
PFIZER | 2004-10-01 |
| 420 | Linezolid In The Treatment Of Subjects With Nosocomial Pneumonia Proven To Be Due To Methicillin-Resistant Staphylococcus Aureus PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine if linezolid is superior to vancomycin in the treatment of nosocomial (acquired in the hospital) pneumonia due to Methicillin Resistant Staphylococcus Aureus (MRSA) in adult subjects. Subjects entered in to the study will have proven healthcare-associated methicillin-resistant Staphylococcus aureus pneumonia which will be treated with either linezolid or vancomycin. |
PFIZER | 2004-10-01 |
| 421 | A Phase III, Randomized, Double-Blind Study of Ceftobiprole Versus Comparator in The Treatment of Complicated Skin and Skin Structure Infections PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril versus a comparator in the treatment of patients with complicated skin and skin structure infections. |
BASILEA PHARMACEUTICA | 2004-10-01 |
| 422 | Vancomycin for Prophylaxis of PEG-Related Wound Infection in MRSA-Positive Patients: A Double-Blind, Randomized, Placebo-Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine whether vancomycin with cefazoline is superior to vancomycin with placebo in preventing gastrostomy-related wound infection in carriers of methicillin-resistant staphylococcus aureus (MRSA). |
ALAIN VONLAUFEN; | 2004-09-01 |
| 423 | A Multi Centre, Double-Blind, Randomised, Placebo Controlled Prospective Study on The Safety and Efficacy of Aurograb in Patients With Severe, Deep-Seated Staphylococcal Infections Receiving Vancomycin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study hypothesis is that the addition of Aurograb to standard vancomycin therapy will improve outcome in MRSA infection. |
MARK H WILCOX; | 2004-01-01 |
| 424 | A Clinical Research Study to Evaluate The Safety and Efficacy of Tigecycline in The Treatment of Selected Serious Infections Caused By Vancomycin-Resistant Enterococcus (VRE) or Methicillin-Resistant Staphylococcus Aureus (MRSA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and efficacy of tigecycline in the treatment of selected serious infections caused by VRE. The primary efficacy endpoint will be the clinical response for all subjects. |
WYETH IS NOW A WHOLLY OWNED SUBSIDIARY OF PFIZER | 2003-10-01 |
| 425 | New Introducer PEG-Gastropexy Does Not Need Prophylactic Antibiotics: Prospective Randomised Double Blind Placebo Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Peristomal infections are the commonest complications of PEG despite prophylactic antibiotics which may result in emergence of resistant micro-organisms like Methicillin resistant Staphylococcus aureus (MRSA). Introducer PEG technique avoids the sojourn of PEG catheter through the oropharynx so chances of infectious complications are negligible. It was not popular because of associated risks and complications. However the new introducer PEG gastropexy has been recently proved to be safe. To determine the incidence of peristomal wound infections during the immediate 7 day post procedure follow up period after the new introducer PEG gastropexy |
YOGESH M SHASTRI; | 2003-10-01 |
| 426 | Linezolid (PNU-10766/PNU10766SS) in The Treatment of MRSA Infections in Patients Whose Conventional Therapy Has Failed, or Who Are Intolerant to Conventional Therapy; An Open-label, Multi-center Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Use of linezolid in patients with methicillin-resistant Staphylococcus aureus infections in Japan |
PFIZER | 2003-01-01 |
| 427 | Diagnosis of Ventilator- Associated Pneumonia in Children: A Comparative Study of Bronchoscopic and Non-Bronchoscopic Methods Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Objectives: There is a need to validate and suggest easy and less costly diagnostic method for diagnosis of ventilator-associated pneumonia in developing country. The study was performed to compare available methods for the diagnosis and to characterize the organisms causing VAP. Design and Methods: All patients on mechanical ventilation for more than 48 hours and simplified CPIS ≥ 6 were enrolled prospectively. Four diagnostic procedures, endotracheal aspiration (ETA), blind bronchial sampling (BBS), … |
ANIL SACHDEV; | 2003-01-01 |
| 428 | Evaluation of Two Protocols to Prevent The Acquisition of Methicillin-Resistant Staphylococcus Aureus in Intensive Care Units PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Nosocomial infections is a major problem in intensive care units due to both growing incidence and pathogens implicated which become increasingly resistant to antibiotics. According to the Center for Disease Control (USA), Staphylococcus aureus is responsible for approximately 10% of cases. In Europe, 79% of the S.aureus strains are resistant to methicillin, … |
CHRISTOPHE CAMUS; | 2002-12-01 |
| 429 | Investigation of The Influence of Intranasal Mupirocin on The Prevalence of S. Aureus Nosocomial Infections By Eradication of Intranasal S. Aureus PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on subsequent Staphylococcus aureus infection, a prospective randomized trial was performed particularly including patients with predisposing risk factors for S. aureus infections. |
CHRISTOF VON EIFF; | 2002-11-01 |
| 430 | A Randomized, Open Label, Multi-Center Clinical Trial, Comparing Microbiologic Response To Linezolid And Vancomycin In Ventilator-Associated Pneumonia (VAP) Due To Methicillin Resistant Staphylococcus Aureus (MRSA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Ventilator-associated pneumonia (VAP) is a commonplace complication of intensive care patients ventilated for longer than 48 hours. Methicillin-resistant Staphylococcus aureus (MRSA) is the cause of late onset VAP in up to about 30% of cases in US hospitals. Ineffective treatment of MRSA VAP clearly leads to prolonged mechanical ventilation and is probably associated with higher mortality. The purpose of this protocol is to directly compare linezolid and vancomycin specifically for MRSA VAP. |
PFIZER | 2002-11-01 |
| 431 | Can Change in Physicians’ Prescribing Habits Decrease Carriage of Resistant Bacteria in The Community? PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to implement judicious antibiotic prescription habits to primary care pediatricians using a multifacet educational intervention and assess two main outcomes: 1) Direct outcome – prescription rates of the physicians. 2)Indirect outcome – carriage of antibiotic resistant bacteria by the treated population, specifically nasopharyngeal S. pneumoniae, nasal S. aureus and rectal E.coli. |
SHEBA MEDICAL CENTER | 2002-02-01 |
| 432 | The Value of Whole Body Washing With Chlorhexidine for The Eradication of MRSA – A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether whole body washing with chlorhexidine in combination with mupirocine nasal ointment is effective in the eradication of meticillin-resistant Staphylococcus aureus (MRSA). |
CONSTANZE WENDT; | 2001-01-01 |