Clinical Digest: Recent Clinical Trials on Overweight (Obesity)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Overweight (Obesity). These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Overweight (Obesity)
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Engagement of CoMmunity Through Participatory Learning and Action for COntrol and PreVEntion of Type II Diabetes and Its Risk Factors [EMPOWER-D]: Cluster Randomized Controlled Trial PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to adapt, implement, and evaluate Participatory Learning and Action (PLA) based intervention in rural areas of KPK, Pakistan which includes Peshawar and Swabi for TIIDM prevention and control. The pivotal components of this approach include adapting, implementing, and evaluating the PLA-based intervention for the prevention and control of Type II diabetes. These components will be tailored to meet the specific needs of two different settings in Peshawar and Swabi, Pakistan. Type II Diabetes Mellitus (TIIDM) is considered the fastest-growing health emergency, … |
DR ZIA UL HAQ; | 2025-05-01 |
| 2 | Implementation of The New Pediatric Obesity Clinical Practice Guideline in Rural Families and Clinics: A Randomized Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The current study is a multilevel factorial design RCT with interventions at the clinic (Healthy Clinic intervention period vs. Control period) and individual patient levels (iAmHealthy vs. Newsletter). |
ANN DAVIS; | 2025-05-01 |
| 3 | A Master Protocol to Investigate The Efficacy and Safety of Orforglipron Once Daily in Participants With Hypertension and Obesity or Overweight: Randomized, Double-Blind, Placebo-Controlled Trials (ATTAIN-HYPERTENSION) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: GZL2 is an independent study conducted under the GZPL master protocol. GZL2 study will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight. |
JOSEPH LILLO; | 2025-05-01 |
| 4 | Nutritional Approach for The Transformation and Reduction of Chronic Disease Indicators in Middle-aged Adults at High Risk PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effect of a multifactorial lifestyle intervention combining Mediterranean diet, energy reduction and physical activity on weight loss in middle-aged adults (men and women 30-50 years old) with metabolic syndrome. The main questions it aims to answer are: Is a multifactorial intervention based on Mediterranean diet, … |
LIDIA DAIMIEL RUIZ; | 2025-05-01 |
| 5 | Open Trial of A Technology-Based Intervention for Dysregulated Eating in Adolescents With or At Risk for Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this project is to pilot test a novel mobile app intervention for adolescents with dysregulated eating behaviors and elevated weight status. This intervention will incorporate evidence-informed strategies targeting self-regulation into cognitive-behavioral treatment for maladaptive eating. Adolescents will use the app for 16 weeks and provide feedback on its usability and effectiveness in managing dysregulated eating. |
ANDREA GOLDSCHMIDT; | 2025-05-01 |
| 6 | Effectiveness of A Role-play Based School Intervention in Primary School Students: A Non-randomized Cluster Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 235 / 5.000 Investigators aimed to reduce the risk of obesity by trying a new intervention method that is role-play based, interactive and fun with age-appropriate play materials, considering that learning through play is more efficient. |
LACIN AKSOY; | 2025-05-01 |
| 7 | OneSTOP (One-Stop Telehealth Obesity Program): The Use of Telecare and Digital Platforms for Multidisciplinary Management of Weight Management and Related Comorbidities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if the use of a care model including teleconsults and the EMPOWER app can induce clinically significant weight loss and metabolic improvements in obese adults with diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will compare this model with the conventional standard of care of physical visit-based weight management program to see if this model is non-inferior to the standard of care for inducing weight loss, and if there is greater patient convenience with telehealth and more frequent self-monitoring, … |
JOAN KHOO JOO CHING; | 2025-05-01 |
| 8 | Metabolic Health, Bones and Nuts Sources of Fatty Acids During Weight Loss in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain, and several dietary pattern studies indicate that nuts and legumes are associated with better bone health. In addition, … |
SUE A. SHAPSES; | 2025-05-01 |
| 9 | Assessing Better Bottles for Babies (AB3) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will use a 2 x 2 factorial design to test impact of two intervention strategies (bottle size and bottle opacity) on infant weight gain. |
CHARLES T WOOD; | 2025-05-01 |
| 10 | Effect of Dietary Energy Restriction on Reversing Isolated Impaired Fasting Glucose: A Proof of Concept Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the preliminary efficacy of a low-calorie diet (LCD) intervention in addressing the underlying pathophysiological abnormalities and improving fasting hyperglycemia among individuals with isolated impaired fasting glucose (i-IFG). Additionally, it seeks to assess the feasibility and acceptability of the LCD intervention. |
SATHISH THIRUNAVUKKARASU; | 2025-05-01 |
| 11 | WIN: A Feasibility Study of A Weight-Neutral Health Intervention. Lighthouse Consortium on Obesity Management (LightCOM) Trial No 1 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The WIN intervention aims to improve the mental, social and physical health as well as quality of life of participants with BMI≥30 without focusing on their weight, and with no aim of weight loss. The WIN 6 months intervention is based on the principles and methods of the weight neutral movement Health at Every Size (HAES). The content is developed in a co-design process that involved Danish participants who have lived or professional experiences with such approaches. The intervention uses the method of intuitive eating to align eating behaviours with internal cues of hunger and fullness rather than rules, … |
CARSTEN DIRKSEN; | 2025-05-01 |
| 12 | Effects of Tirzepatide on Fat-Free Mass, Bone and Physical Function in Older Adults – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to examine how tirzepatide affects body composition, bone health, and physical performance in older adults over a nine-month period. Participants will take tirzepatide weekly, have clinic visits every 4 weeks, meet study doctor and registered dietitian every 4 weeks in person or video conference, attend group intervention sessions twice a month via video conference, weigh daily with a study-provided smart scale, keep a record of all foods and beverages consumed, and use a study-provided activity tracker to keep track of daily step counts. |
DENISE HOUSTON; | 2025-05-01 |
| 13 | Adapting An Adolescent Weight Management Program for A Type 1 Diabetes Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Before the 1990s, obesity was rare among young people with type 1 diabetes (T1D), but now it is more common. Recent studies show that over 50% of young people with T1D will have overweight or obesity within five years of being diagnosed with T1D. Both obesity and T1D increase the risk of heart disease, and combined, these risks are even higher. Intensive health behavior and lifestyle treatments (IHBLTs) are proven to be effective for treating childhood obesity. However, managing T1D creates unique challenges that require adjustments to these treatments. For example, … |
JENNY WARNICK; | 2025-05-01 |
| 14 | Cerebral Lactate Uptake and Transport in Obese and Non-Obese Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity. Reduced CBF can impair the brain’s ability to meet its metabolic demands, leading to deficits in cognitive ability. Impairments in CBF are associated with cognitive decline and neurodegenerative disease such as Alzheimer’s and dementia. Many factors influence CBF, but recently lactate has emerged as a key player. Blood glucose has long been considered the primary fuel for the brain, but emerging evidence indicates that lactate may be the preferred fuel for neurons, … |
JILL KANALEY; | 2025-05-01 |
| 15 | Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health in Postmenopausal Women Living With Overweight and at Moderate Risk for Cardiovascular Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In a single-blind, randomised, placebo-controlled crossover manner, this study aims to assess the impact of a high-fat mixed meal containing a whey protein (WP)-enriched milk fat globule membrane (MFGM) powdered ingredient on markers of heart and brain health in the fed state among middle-to-older-aged, postmenopausal women living with overweight and at moderate risk for cardiovascular disease. Participants will attend two \~8 hour study visits, where they will consume a high-fat meal containing a WP-enriched MFGM powdered ingredient or a placebo WP-based powdered ingredient. Each visit will involve anthropometric measurements and periodic assessments of heart health, … |
OONAGH MARKEY; | 2025-05-01 |
| 16 | Effects of Antagonizing The Ghrelin Receptor on Brain Food Cue Reactivity in Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The naturally occurring peptide hormone liver-expressed antimicrobial peptide 2 (LEAP2) in an antagonist/inverse agonist towards the ghrelin receptor. Ghrelin administration has previously been shown to increase food cue reactivity in brain regions related to appetite and reward using functional MRI scans. The aim of this clinical study is to investigate the effects of LEAP2 infusion on food cue reactivity in brain regions related to appetite and reward. Since LEAP2 is an antagonist/inverse agonist towards the ghrelin receptor we hypothesize, … |
ANDERS ENGLUND; | 2025-05-01 |
| 17 | Effect of Tirzepatide on Markers of MASLD in Patients With Obesity: A Pilot Study Related Papers Related Patents Related Grants Related Experts View Highlight: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is the most common cause of chronic liver disease worldwide and predominately affects individuals with overweight and obesity, as well as those with type 2 diabetes and cardiovascular disease. Tirzepatide is a medication used to treat type 2 diabetes and obesity. It has also been shown to help with MASLD. The purpose of this study is to study how tirzepatide affects the liver in patients with MASLD. Participants will be asked to: * Take tirzepatide for 12 months. * Come in for clinic visits every 3 months. * Have blood drawn at baseline, 6, … |
ELISEO CASTILLO; | 2025-05-01 |
| 18 | Mechanisms of Deep Transcranial Magnetic Stimulation Enhances The Efficacy of Cognitive-behavioral Therapy (CBT) By Modulating Anterior Cingulate Cortex in Patients With Anorexia Nervosa PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if dTMS targeting the ACC can be used to rapidly and effectively treat AN. A randomized controlled study design is adopted, in which patients with AN are divided into the CBT+dTMS treatment group and CBT+pseudostimulation group by 1:1 randomization, followed by a 6-week intervention and a half-year follow-up to clarify whether CBT combined with dTMS is superior to single CBT treatment for AN. |
JUE CHEN; | 2025-04-30 |
| 19 | A Phase 3, Double Blind, Randomized, Placebo-Controlled Trial to Evaluate The Efficacy and Safety of Setmelanotide in Patients With Acquired Hypothalamic Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a sub-study of Study RM-493-040 (NCT05774756). The goal of this sub-study is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years of age and older with congenital Hypothalamic Obesity (cHO). To determine how well setmelanotide works and how safe it is, patients with cHO will take a daily injection of either setmelanotide or placebo and complete trial assessments for up to 26 weeks on a therapeutic regimen. |
RHYTHM PHARMACEUTICALS | 2025-04-30 |
| 20 | Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators hypothesize that combined treatment with the GLP-1R agonist semaglutide 2.4 mg and levonorgestrel intrauterine device (LNG-IUD), compared to LNG-IUD alone, will result in improved likelihood of uterine preservation, sustained weight loss, improved endometrial and metabolomic response to progestin, and improved quality of life in premenopausal women with endometrial hyperplasia who desire uterine preservation. |
ANDREA R HAGEMANN; | 2025-04-30 |
| 21 | Investigation of Factors That May Affect Headache in Individuals with Juvenile Onset Systemic Lupus Erythematosus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of our study was to compare individuals with juvenile onset systemic lupus erythematosus with and without headache in terms of pain, pain catastrophizing behavior, demographic and individual disease-related factors that may affect headache and temporomandibular joint dysfunction. |
ZÜLAL TATAR; | 2025-04-24 |
| 22 | Cities for Better Health Childhood Obesity Prevention Initiative: A Multi-country Community-based Prevention and Intervention Project Targeting Childhood Obesity Through Diet and Physical Activity Interventions in Disadvantaged Communities of Urban Areas PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This research project is part of the ‘Cities for Better Health Childhood Obesity Prevention Initiative’ (CBH COPI), which aims to understand how interventions designed to improve diet and physical activity can impact children’s health. |
NOVO NORDISK | 2025-04-22 |
| 23 | A Phase I, Randomised, Investigator- and Participant-blinded, Placebo-Controlled, Study to Assess The Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the safety and tolerability, and pharmacodynamics (PD) of AZD4144 administered as repeated daily oral dosing. |
ASTRAZENECA | 2025-04-22 |
| 24 | A Randomized, Double-Blind, Phase 2 Trial of Once-Weekly Petrelintide Compared With Placebo in Participants With Overweight or Obesity and Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to investigate efficacy and safety of three doses of petrelintide versus placebo in participants with overweight or obesity and type 2 diabetes. |
ZEALAND PHARMA | 2025-04-21 |
| 25 | Breastmilk Composition in Response to A Bout of Exercise PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to unveil the mechanistic benefits of a bout of postpartum maternal exercise on infant health that are provided by breastmilk. |
MARK PATAKY; | 2025-04-21 |
| 26 | Empowering Healthy Lifestyle Behaviour Through Personalized Intervention Portfolios to Prevent and Control Obesity in Young Adults – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This human study will be a pilot trial that will precede a planned more long-term intervention trial. It will focus on young adults (age 18 to 25 y). The main purpose is to study whether the healthy lifestyle recommender solution, reflecting a multi-portfolio intervention and developed within this project, is well accepted by the participants, has a decent adherence (i.e. user time of the app), and whether the overall design is well suited to the participants, in order that they will improve dietary habits. This study will be of longitudinal design without a control group. At present, … |
ELSA LAMY; | 2025-04-21 |
| 27 | Impact of Maternal Body Mass Index on Infant Hypoxic Events at Time of Delivery ,Cross-sectional Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Offspring from overweight or obese mothers appear to be at up to 38% increased risk of being admitted to the neonatal intensive care unit than the offspring of mothers with a normal BMI. In terms of Apgar scores at birth, babies of obese mothers have been reported to have a 31% excess risk of having a low Apgar score (defined at \<7 at 1 minute) . Infants born to obese mothers demonstrate a spectrum of outcomes, ... |
AIN SHAMS UNIVERSITY | 2025-04-20 |
| 28 | Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the control effect of smart wearable devices on key risk factors in the high-risk populations for stroke |
AFFILIATED HOSPITAL OF NANTONG UNIVERSITY | 2025-04-20 |
| 29 | An Active-comparator-controlled, Open-label, Parallel Group Study to Evaluate The Effect of Survodutide on Energy Expenditure and Fatty Acid Oxidation in Subjects With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults between 18 and 65 years of age who have obesity. People can join the study if they have a body mass index (BMI) between 30 and 45 km/m². The purpose of this study is to find out whether a medicine called survodutide improves how the body uses energy and breaks down fat. This study compares survodutide with another medicine called semaglutide. Survodutide is being developed to treat people with obesity. Semaglutide is already used to treat people with obesity. Participants are put into 2 groups by chance. One group gets survodutide and the other group gets semaglutide. Participants get survodutide or semaglutide as an injection under the skin once a week. Participants are in the study for 8-10 months depending on how long the treatment is given. During this time, they visit the study site weekly. Some of the visits may also be done at the participant’s home instead of the study site. At some of the visits, doctors test how much energy a participant’s body uses. This is done in a special room where they measure the oxygen that is breathed in and the carbon dioxide that is breathed out by the participant. The results are compared between the 2 groups to see whether the treatment works. The doctors also regularly check participants’ health and take note of any unwanted effects. |
BOEHRINGER INGELHEIM | 2025-04-18 |
| 30 | Utilizing Dietician-guided Intervention to Combat Neurogenic Obesity in People With Spinal Cord Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the effects of a 9-week dietician-guided program modified from the National Diabetic Prevention Program (modified DPP-diet) in people with spinal cord injury on body composition and insulin sensitivity. The main question it aims to answer is: Does 9 week modified DPP-diet reduce body fat percentage and insulin resistance? Participants will: Have 9 weeks of Telehealth visit with dietician certified in providing DPP. Visit the laboratory before, … |
YI-TING TZEN; | 2025-04-16 |
| 31 | New Dietary Intervention Strategies on The Intestinal Microbiota to Improve Mental Health Subjects With Obesity: Therapeutic Potential of A Synbiotic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Obese individuals are a particularly vulnerable population for mental health problems, especially depression and anxiety. The aim of this study is to evaluate whether the intake of a synbiotic, composed of prebiotics and beneficial intestinal bacterial strains, is capable of producing changes in the gut microbiota and its functionality, improving metabolic and inflammatory parameters, intestinal function and appetite control in patients with obesity and psychological disorders. In addition, the production of neurotransmitters at the level of the gut-brain axis will be studied, as well as mood and quality of life. For this purpose, a prospective, randomized, doubleblind, … |
CELIA BAÑULS; | 2025-04-15 |
| 32 | Effects of Low-intensity Blood Flow Restriction Exercise on Aerobic Capacity, Muscle Strength, Muscle Size, Biochemical-hormonal Parameters and Antioxidant Parameters in Overweight and Obese Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Participants will be selected from sedentary men aged 18-30 and over with a body mass index of 25. First, an informed consent form will be signed by the individuals. The ‘International Physical Activity Questionnaire’ will be applied to the participants and it will be ensured that the participants have not participated in vigorous and moderate activities and therefore are inactive or minimally active individuals. The study will consist of an intervention group and a control group, … |
YASIN ATAY; | 2025-04-15 |
| 33 | Comparison of Aerobic Training and Circuit Training on Body Mass Index, Physical Fitness, and Quality of Life in Healthy Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood obesity is a growing concern, with potential consequences for long-term health. The number of obese children has increased more than tenfold in the last forty years. Over the course of their lifetimes, more and more young people worldwide will be exposed to obesity, which will hasten the onset of type 2 diabetes, fatty liver, … |
ANIQA ASIF; | 2025-04-15 |
| 34 | Dietary Modification Intervention Involving Family Support (FamNUTRI) for Managing Sarcopenic Obesity Among Community-dwelling Older Adults: A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot RCT is to examine the feasibility and preliminary effects of a dietary modification intervention involving family support (FamNUTRI) on the management of sarcopenic obesity among older people living in the community. The main questions it aims to answer are: 1. Is the intervention feasible and acceptable for community-dwelling older people with sarcopenic obesity? 2. What are the preliminary effects of the intervention on managing sarcopenic obesity in this population? Researchers will compare the FamNUTRI group, the NUTRI group, … |
JUSTINA LIU YAT WA; | 2025-04-15 |
| 35 | Emotion Regulation Intervention to Improve Neural Responsiveness and Health PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if an emotion regulation and self-monitoring intervention can help treat overweight and obesity in teens. The main question it aims to answer is: * Does emotion regulation and self-monitoring help reduce biases in teens with overweight and obesity? * Do changes in biases relate to changes in health functioning and health behavior? Researchers will compare the intervention to the provision of educational handouts about overweight and obesity to see if the intervention is more effective. Participants will: * Complete self-report questionnaires, an fMRI scan, … |
CAROLINE CUMMINGS; | 2025-04-15 |
| 36 | Decentralised Observational Disease Area Study Exploring Remote Collection of Data in Adult Participants With Overweight Condition or Obesity Undergoing Weight Management Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to collect health data related from participants living with an overweight condition in a decentralised clinical study set-up. All data will be collected remotely using an app downloaded on your personal smartphone and devices (watch and scale). Participants will participate in this study for 24 weeks. The study does not include any study medicine. |
NOVO NORDISK | 2025-04-14 |
| 37 | Empowering Healthy Lifestyle Behaviour Through Personalised Intervention Portfolios to Prevent and Control Obesity in Children – UEV Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being performed under the European Consortium HealthyW8 that has the main objective of developing a digital tool for personalized recommendations for healthy lifestyle and prevention of obesity. This human study will be a pilot trial that will precede a planned more long-term intervention trial. It will focus on children (age 5 to 12 y) and parents. The main purpose is to study whether the healthy lifestyle recommender solution, reflecting a multi-portfolio intervention and developed within this project, is well accepted by the participants, has a decent adherence (i.e. user time of the app), … |
ELSA LAMY; | 2025-04-14 |
| 38 | Combined Effect of High Intensity Interval Training and Ultrasound Cavitation on Lipid Profile in Type 2 Diabetes Patients With Abdominal Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aim to find out the combined effect of high intensity interval training and ultrasound cavitation on lipid profile in type two diabetic patient with abdominal obesity. |
MAHMOUD AWAD RAMADAN ELKHOLY; | 2025-04-11 |
| 39 | A Phase 3 Clinical Study to Evaluate The Efficacy and Safety of HRS-7535 Tablets in Subjects With Overweight or Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being conducted to evaluate the efficacy and safety of HRS-7535 in subjects with overweight or obesity. |
YIMING MU; | 2025-04-09 |
| 40 | Self-administered Auricular Acupressure Integrated With A Smartphone Application for Weight Reduction in Patients With Obesity Accompanied With Obesity-related Comorbid Illness: A Randomised Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn whether self-administered auricular acupressure integrated with a smartphone application works to reduce weight in patients with obesity accompanied with obesity-related comorbid illness. The main questions it aims to answer are: * Is there significant difference in the Body Mass Index (BMI) between the self-administered auricular acupressure integrated with a smartphone app (Version 2) group (experimental group) and the usual care group, in people with obesity accompanied with metabolic syndrome? * Are there significant differences in other anthropometric parameters between the two groups? These parameters include waist circumference, body fat percentage, … |
TUNG WAH COLLEGE | 2025-04-09 |
| 41 | Controlled Feeding With 24 Hour Recall PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines how accurately adults report their food intake using a common self-report method called the 24-hour dietary recall. While this method is widely used in nutrition research, it often leads to underreporting, especially among individuals with overweight or obesity. However, it is unclear if specific foods are more likely to be misreported. To address this, participants will be served a controlled meal containing both simple foods (e.g., fruit snacks, saltine crackers, cookies, and a coke soft drink) and mixed dishes (e.g., chicken salad, … |
SHANNON GALYEAN; | 2025-04-09 |
| 42 | A Phase II, Randomized Open-label, Multicenter Study to Evaluate The Efficacy and Safety of BGM0504 Compared to Tirzepatide in Adults Who Have Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and safety of BGM0504 compared with Tirzepatide in adult participants who have obesity without diabetes after 26 weeks of treatment. |
BRIGHTGENE BIO MEDICAL TECHNOLOGY | 2025-04-08 |
| 43 | Optimizing Care for Diabetic Patients in Hospitalized Rehabilitation Through Structured Education PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A large number of patients at the Neurological and Functional Rehabilitation Centre of the University Hospital of Liège have associated pathologies, including diabetes. These patients may have diabetes-related complications that require recurrent hospitalizations in an acute structure or in rehabilitation. One of the ways to limit complications is to set up patient education. 1. Objectives * To compare the impact of management through formal education with that of awareness. * To evaluate the impact on knowledge of structured education. * To evaluate the impact of structured education on the quality of life experienced by diabetic patients. * Identify the patient’s level of satisfaction with the education sessions. * To evaluate the impact of structured education on the biological improvement of glycated hemoglobin. * To evaluate the impact of structured education on diabetes-related complications. 2. Working Hypothesis The implementation of structured diabetes education allows patients to acquire, or maintain, the skills they need to manage their lives as well as possible despite the constraints of chronic disease… . 3. Study population All diabetic patients hospitalized in all care units. 4. Collection tools and techniques Collection tools 1. Diabetes Knowledge Questionnaire. 2. SF-36 Health Questionnaire. 3. Satisfaction questionnaire for structured sessions on diabetes. 4. Questionnaire to identify complications and/or re-hospitalizations after your stay in rehabilitation. Collection technology At admission (D+1) * Validation of inclusion and exclusion criteria. * Submission and distribution of the information and consent form. * Obtaining informed consent from the patient. * Distribution of collection tools 1 and 2 (collection on D+2). * Control of glycated hemoglobin. At the end of hospitalization (D-2) * Distribution of collection tools 1, 2 and 3 on D-2 before the release (collection on D-1). * Control of glycated hemoglobin. 3 months after the end of hospitalization * Sending collection tools 1, 2 and 4 by post. The patient will be invited to complete them and return them by post. * The patient will be invited to take a blood test for glycated hemoglobin. |
HELENA CASSOL; | 2025-04-07 |
| 44 | Personalized Metabolic Responses to Rapid, Slow and Resistant Starch (PerStarch) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to investigate how individuals with varying gut microbiota composition and AMY1 gene copy number respond to three different types of starch. A 12-week trial will therefore be conducted, where all participants will go through three different 17-day interventions in a randomized order. Each intervention will contain a different type of starch: A) Resistant starch B) Slow digestible starch C) Rapid digestible starch Each intervention will contain a preparation day, a meal challenge test day at clinic, … |
RIKARD LANDBERG; | 2025-04-07 |
| 45 | A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Evaluating The Efficacy and Safety of Tirzepatide Once Weekly Compared to Placebo in Adult Participants With Type 1 Diabetes and Obesity or Overweight PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to find out how well and how safely tirzepatide works in adults who have type 1 diabetes and obesity or overweight. Participation in the study will last about 49 weeks. |
KRISTIN CASTORINO; | 2025-04-01 |
| 46 | Level Up! (The Combined and Independent Effects of Exercise Training and Dietary Enhancement on Cardiometabolic Health in Adolescents with Obesity) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn how exercise and diet quality affect the health of adolescents with obesity. The main questions it aims to answer are: * Does exercise improve cardiometabolic health in adolescents with obesity? * Does enriching the diet with fruits and vegetables (FV) improve cardiometabolic health in adolescents with obesity? * Do exercise and FV diet together provide greater health benefits than either alone in adolescents with obesity? Researchers will compare four groups to see how exercise and diet impact health: * Standard Care Group: Receives the usual care for obesity. * Exercise Group: Receives weekly exercise coaching and participates in a 12-week exercise program. * Diet Group: Receives weekly dietary coaching and eats a diet enriched with fruits and vegetables for 12 weeks. * Combined Exercise and Diet Group: Receives both exercise and dietary programs, namely weekly exercise and dietary coaching, participation in a 12-week exercise program, and daily consumption of fruits and vegetables for 12 weeks. During the 12-week study, participants will attend three study visits to: * Provide blood, stool, and urine samples. * Answer questions about health, sleep, diet, and physical activity. * Undergo body scans to measure fat, lean, and bone mass. * Complete blood vessel function and liver fat content assessments. * Assess resting exergy expenditure. * Complete fitness tests. * Wear a fitness tracker to monitor physical activity and sleep patterns. |
ELISABET BORSHEIM; | 2025-04-01 |
| 47 | A Single-Dose and Multiple-Ascending Dose Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the safety, tolerability of LY4086940 and how it is processed in the body. Participation in Part A of the study will last about 10 weeks and may include up to 6 visits. Participation in Parts B, C, D will last approximately 15 weeks and may include up to 9 visits. |
HUGH COLEMAN; | 2025-04-01 |
| 48 | A Phase 1, Open-Label, Single and Multiple Dose Study to Investigate The Safety, Tolerability, and Relative Bioavailability of Single and Multiple Weekly Subcutaneous Doses of Eloralintide, and Single and Multiple Weekly Subcutaneous Doses of Eloralintide With Tirzepatide in Participants With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate how well eloralintide and eloralintide with tirzepatide is tolerated and what side effects may occur in participants with overweight or obesity. The study drug will be administered subcutaneously (SC) (under the skin). Blood tests will be performed to check how much eloralintide and eloralintide with tirzepatide get into the bloodstream and how long it takes the body to eliminate it. There will be 6 cohorts. The study will last up to approximately 26 weeks, excluding screening for Cohorts A and B, 11 weeks for Cohorts C and D, … |
ELI LILLY | 2025-04-01 |
| 49 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Study To Evaluate The Efficacy And Safety Of DA-302168S Tablets In Overweight/Obese Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It is a multicenter, randomized, double-blind, placebo-controlled phase II clinical trial to evaluate the safety and efficacy of DA-302168S tablets in overweight and obese adults. |
CHENDU DIAO PHARMACEUTICAL GROUP | 2025-04-01 |
| 50 | Dietary Fish Oil and Metformin Intervention for Heart Health in PCOS PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes. |
UNIVERSITY OF ALBERTA | 2025-04-01 |
| 51 | Exploring The Interplay Between Gut Barrier and Blood-Brain Barrier Integrity, Systemic Inflammation, and Cognitive Function in Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to understand how obesity affects the function of the gut and blood-brain barriers in adults. These barriers protect the body and brain from harmful substances, … |
ASGER LUND; | 2025-04-01 |
| 52 | Pylorus Distensibility Measurement in Overweight and Obese (BMI 27-40) Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study aims at characterizing the pylorus functionality in overweight and obese patients (BMI 27-40) using a systematic measurement approach by using an impedance planimetry technology. |
BARIATEK MEDICAL | 2025-04-01 |
| 53 | An Open-Label, Single-Dose, Pharmacokinetic Study of Vancomycin Dosed By Weight or Kidney Function in Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn how to optimize vancomycin dosing in obese adults based on weight and kidney function. It will also assess the safety of different vancomycin dosing strategies. The main questions it aims to answer are: Does dosing vancomycin based on kidney function provide better drug exposure than dosing based on weight? What medical or safety issues arise when vancomycin is dosed according to weight versus kidney function? Participants will be randomized into two groups. One group will receive vancomycin doses based on their weight, … |
MANJUNATH PRAKASH PAI; | 2025-04-01 |
| 54 | Evaluation of A Digital Treatment Tool in Combination with Anti-Obesity Medications PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effect of adding a digi-physical treatment tool as a complement to the local treatment with anti-obesity medication in adolescents with obesity. The main question it aims to answer is: – Can a combination of a digi-physical treatment tool and anti-obesity medication improve treatment outcomes for patients with obesity compared to patients treated with anti-obesity medications alone? This is a randomized controlled two-arm multicenter study where participants will be randomized to the intervention group (digi-physical treatment+medication) or control group (medication only). Participants will be followed for six months. |
PERNILLA DANIELSSON; | 2025-04-01 |
| 55 | A Phase Ⅰ Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-5817 Injection in Healthy Adult Volunteers With or Without Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-5817 when administered subcutaneously (SC) as single ascending doses in adults who are affected by obesity. |
WEI HU; | 2025-04-01 |
| 56 | Effect of Tirzepatide-Induced Weight Loss on Adipose Tissue in Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is testing whether a new anti-obesity medicine called tirzepatide can increase the activity of special fat cells in the body that help burn energy. These fat cells are known as brown and beige fat. The study includes women with obesity and will last 24 weeks. Participants will receive either tirzepatide or a placebo (a look-alike injection with no active drug). Researchers will measure the amount and activity of brown fat using medical imaging (PET/CT, MRI, and thermal camera), … |
UNIVERSITY MEDICAL CENTRE LJUBLJANA | 2025-04-01 |
| 57 | Efficacy of Probiotics on Postprandial Energy Metabolism of Adults with Overweight or Obesity: An EXploratory Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This exploratory, double-blinded clinical trial on 66 randomized adults aged 50 to 70 years with moderate overweight or obesity but considered metabolically healthy will consist of comparing metabolic and microbiota parameters before and after 3 months of consumption of a probiotic or a placebo. |
LALLEMAND HEALTH SOLUTIONS | 2025-04-01 |
| 58 | A Phase 1, Investigator- and Participant-Blinded, Placebo Controlled, Randomized, Single Dose Study to Investigate The Safety, Tolerability, and Pharmacokinetics of Eloralintide (LY3841136) in Chinese Participants With Obesity or Overweight PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate how well Eloralintide (LY3841136) is tolerated and what side effects may occur in overweight and obese Chinese participants. The study drug will be administered subcutaneously (SC) (under the skin). Blood tests will be performed to check how much Eloralintide gets into the bloodstream and how long it takes the body to eliminate it. The study will last approximately 10 weeks excluding a screening period. |
ELI LILLY | 2025-04-01 |
| 59 | Impact of A Structured Physical Exercise Program on Body Composition in Morbid Obesity: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to determinate whether a structured exercise program, supported by telerehabilitation, can help individuals with severe obesity who are going to undergo bariatric surgery. The main objective of this study is whether a structured exercise program, including both supervised and home-based workouts, leads to greater body fat loss and improved strength compared to usual care. Furthermore, it also aims to evaluate other potentially affected aspects, such as body composition and functionality, quality of life, cardiovascular fitness, … |
PAOLO ROSSETTI; | 2025-04-01 |
| 60 | A Phase 2, Double Blind, Randomized, Placebo-controlled Crossover Trial to Evaluate The Efficacy and Safety of Atomoxetine in Adults with Melanocortin Obesity Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2 randomized placebo-controlled crossover trial to determine the safety and efficacy of atomoxetine for treating obesity caused by loss-of-function variants in the melanocortin-4 receptor (MC4R), the most common cause of genetic obesity disorders. Atomoxetine was selected for this pilot trial because it has been shown to increase brain-derived neurotrophic factor (BDNF) within the central nervous system and in peripheral circulation. Targeting BDNF is a specific strategy for treating MC4R abnormalities because BDNF functions as a downstream mediator of MC4R signaling. |
JOAN HAN; | 2025-04-01 |
| 61 | Fostering Patient-oriented Research in Cardiometabolic Disease Pathogenesis and Prevention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to 1) use magnetic resonance imaging (MRI) to evaluate the effect of nutritious foods on inflammation in the human hypothalamus of children and 2) assess the feasibility and acceptability of nutritious food feeding intervention strategies in children with overweight or obesity. |
ELLEN SCHUR; | 2025-04-01 |
| 62 | Exploring The Effects of Time-restricted Feeding on The Immune Function of Obese Individuals: Multi-omic Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized trial is to: 1) investigate the immunological landscape of patients with obesity and conduct an in-depth functional characterization of their immune system; and 2) precisely define the effects of time-restricted feeding (TRF) on immune function in patients with obesity; 3) define the immunomodulatory properties of white adipocytes in response to TRF, … |
LIONEL REBIBO; | 2025-04-01 |
| 63 | Effect of Increased Physical Activity and Stopping Evening Snacking in Metabolic Health in Youth With Prediabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-healthy eating habits and a lack of exercise contribute to prediabetes and type 2 diabetes (T2D). Evening snacking is linked to abnormal weight gain in adults and healthy adolescents. Most adolescents do not get enough exercise. This study aims to look at the benefits of more exercise and stopping evening snacking in youth with prediabetes. The study lasts 8 weeks, and participants will be randomly assigned to either an intervention group or a standard of care group. |
MUSTAFA TOSUR; | 2025-04-01 |
| 64 | Effects of HIIT and Concurrent HITT/Plyometric Training on Muscle-tendon Structure, Function and Metabolism in Pediatric Population with Obesity At Different Biological Maturation States (HIIT-PRO Kids): A Study Protocol of Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The randomized controlled trial will compare the effects of a High-intensity interval training (HIIT) protocol versus a HIIT plus plyometric training in the muscle-tendon structure function and metabolism of the pediatric population with obesity at different biological maturational stages (pre-to-age peak velocity \[APHV\] and post-APHV). Both groups perform baseline evaluations of the main and secondary outcomes and receive the intervention for twelve weeks, three times per week. Once the interventions are completed, the participants undergo the same evaluations they performed at baseline. |
RODRIGO RAMIREZ; | 2025-04-01 |
| 65 | Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will investigate the effects of alternative nicotine products on smoking, weight gain, and related outcomes. |
BROWN UNIVERSITY | 2025-04-01 |
| 66 | A Double-Blind, Randomized Placebo-Controlled Study to Evaluate A Postbiotic Supplement in Supporting Weight Loss and Metabolic Health PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the impact of a specific oral postbiotic supplement on metabolic health in overweight adults. |
AHMED ABDELGAWAD; | 2025-04-01 |
| 67 | Adaptive Behavioral Intervention Application for Weight Control in Obese/Overweight Endometrial Cancer Patients in Fertility Preservation:A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a single-center, prospective, randomized controlled trial targeting endometrial cancer (EC) patients undergoing fertility-sparing treatment at Peking University People’s Hospital from March 2025 to March 2027. The aim is to evaluate the efficacy of an intelligent mobile application (APP) based on the Adaptive Behavioral Intervention (ABI) framework in weight management for obese or overweight endometrial cancer patients receiving fertility preservation therapy. Additionally, the study seeks to explore its potential advantages in improving body mass index (BMI), tumor regression, and glucose and lipid metabolism profiles. |
XIAODAN LI; | 2025-03-31 |
| 68 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase IIb Clinical Trial to Evaluate The Efficacy and Safety of Efsubaglutide Alfa Injection in Overweight and Obese Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter, randomized, double-blind, placebo-controlled Phase IIb clinical trial aimed at evaluating the efficacy, safety, pharmacokinetics (PK), and immunogenicity profile of Efsubaglutide Alfa injection in overweight and obese subjects. The primary endpoint is the percentage change in body weight from baseline after 18 weeks of treatment. |
WEIPING JIA; | 2025-03-31 |
| 69 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Clinical Study Evaluating The Efficacy and Safety of HRS-7535 in Subjects With Heart Failure With Preserved Ejection Fraction and Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled, parallel design phase II clinical trial, including a screening period of up to 2 weeks, a 40-weeks’ treatment period, and a 1-week safety follow-up visit period. |
YUHUI ZHANG; | 2025-03-31 |
| 70 | TIRO-AF: TIRzepatide for The Treatment of Obesity in Patients With Atrial Fibrillation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center randomized double blind controlled study of patients (BMI\> 30 kg/m2) with obesity and Atrial Fibrillation (AFIB) randomized to Tirzepatide vs. placebo. It is expected that the significant weight loss with Tirzepatide will result in improved control, management, symptom severity, and burden of AFIB at 12 months. |
LESLIE CHO; | 2025-03-31 |
| 71 | A Multicenter, Randomized, Open-label Phase III Study to Compare The Efficacy and Safety of IBI362 and Semaglutide in Chinese Overweight or Obese Subjects With Metabolic Dysfunction-associated Fatty Liver Disease (GLORY-3) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, open-label Phase 3 clinical study comparing the efficacy and safety of IBI362 9 mg QW versus Semaglutide 2.4 mg QW in overweight or obese (BMI≥27kg/m2) MAFLD subjects. Subjects will be randomly assigned to IBI362 9 mg and Semaglutide 2.4 mg groups. All study treatment will be administered once-weekly and subcutaneously. The entire trial cycle includes a 4-week screening period, a 48-week open-label treatment period, and a 12-week drug withdrawal safety follow-up period. |
LIXIN GUO; | 2025-03-31 |
| 72 | Families in Balance: Enhancing Household Routines and Reducing Early Childhood Obesity Among Families With Low-income PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effects of two different approaches to support healthy family mealtime, sleep, and screentime routines: A parent leader-guided online program that promotes parent and child self-regulation as a means to improve healthy family routines versus an asynchronous program that provides parents information about healthy family routines. Families will be randomly assigned to either of these programs and changes in parent and child outcomes will be evaluated. |
KATHERINE BAUER; | 2025-03-31 |
| 73 | Utilization of Airway Stabilizing Rod to Assist With Laryngeal Mask Airway Guided Fiberoptic Intubation in Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The FASTER stabilizing rod offers the distinct advantage of intubating through the laryngeal mask airway with a fiberoptic scope via the FASTER stabilizing rod. The device allows for the provider to insert the endotracheal tube (ETT) with visual confirmation using the fiberoptic scope into the trachea. The device then allows for the laryngeal mask airway to be removed while stabilizing the ETT to ensure the ETT does not get dislodged. The purpose of this protocol is to clinically test the validated prototype that the investigators have built and previously tested in adults with obesity. The primary aims are to evaluate 1) the time to intubation and 2) the number of intubation attempts. The secondary aim is to note any complications from time to intubation to PACU discharge. These complications include: Hypoxemia (10% decrease from baseline for 45 seconds)1 Airway trauma (minor) Esophageal intubation Laryngospasm Bronchospasm Oro-pharyngeal bleeding Arrythmia Emesis Epistaxis Dental damage Post-operative sore throat Post-operative hoarseness Accidental extubation during removal of the LMA. |
KEVIN W DUONG; | 2025-03-31 |
| 74 | Effects of Ultra Processed Food on Intestinal Energy Harvest PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ultra processed food is everywhere in modern society and may contain multiple ingredients that affect the way participants’ bodies store energy. Some studies have shown that eating a diet high in ultra processed foods leads to weight gain, but these foods have not been studied enough to understand why. Recently, the gut microbiome has become a potential way to measure energy balance in the human body; … |
KATHRYN J. WHYTE; | 2025-03-30 |
| 75 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Trial to Evaluate The Safety and Efficacy of HDM1002 Tablets in Chinese Overweight and Obese Adults PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase 3 Trial to Evaluate the Safety and Efficacy of HDM1002 Tablets in Overweight and Obese Adults |
HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL | 2025-03-28 |
| 76 | A Parallel-Group Treatment, Phase 2, Double-Blind Study of Once-Weekly Subcutaneous LY3457263 Compared to Placebo in Participants With Type 2 Diabetes Mellitus on A Stable Dose of Semaglutide or Tirzepatide Who Failed to Achieve HbA1c Goal PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months. |
ELI LILLY | 2025-03-28 |
| 77 | A Single Center, Open-label, Fixed Sequence Trial, Investigating The Influence of BGM0504 Injection on Gastric Emptying and Pharmacokinetics of Metformin and Warfarin in Overweight or Obese Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the influence of BGM0504 injection on gastric emptying and Pharmacokinetics of metformin and warfarin in overweight or obese participants |
BRIGHTGENE BIO MEDICAL TECHNOLOGY | 2025-03-24 |
| 78 | Whole Foods for Teens: A Pilot Dietary Intervention to Reduce Body Adiposity in Adolescents With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will address the following aims: Aim 1: Conduct an 8-week pilot RCT to examine the effects of a whole foods diet intervention on body adiposity in adolescents with obesity. Aim 1a (Primary): Evaluate intervention effectiveness on total fat mass following the 8-week intervention. Hypothesis 1a: Adolescents randomized to the whole foods intervention will have lower total fat mass (kg) at the 8-week follow-up than those in the control group. Aim 1b: Evaluate intervention effectiveness on anthropometric changes following the 8-week intervention. Hypothesis 1b: Adolescents randomized to the whole foods intervention will have lower weight, … |
NADIA MARKIE SNEED; | 2025-03-24 |
| 79 | A Phase 4, Prospective, Open-Label, Single Arm Study to Assess The Effectiveness of Tirzepatide After Initiation of Ixekizumab in Adult Participants With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight in Clinical Practice PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe plaque PsO and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months. |
LINDSAY ACKERMAN; | 2025-03-19 |
| 80 | Exploratory Evaluation of The Effect of Cholestyramine on Serum Levels of Persistent Organic Pollutants in Obese Female Patients – OBESE (OBesity, CholEStyramine, WomEn) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Environmental endocrine disruptors (EDCs) represent a major problem for human health.Some PEEs can accumulate in the fatty tissue of the human body thanks to their lipophilic nature, and are known as persistent organic pollutants (POPs). To assess the benefit of cholestyramine treatment on POPs blood levels in obese patients of childbearing age undergoing bariatric surgery, in order to reduce their preoperative POPs load more rapidly. Indeed, the investigators hypothesize that cholestyramine is capable, outside of acute exposure accidents, of promoting the elimination and release of POPs in the human population. Given this hypothesis, … |
NICOLAS CHEVALIER; | 2025-03-19 |
| 81 | A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight (MARITIME-2) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight. |
AMGEN | 2025-03-17 |
| 82 | Breastfeeding Intervention to Prevent Obesity Among Latine Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn how to improve exclusive breastfeeding rates in the Latine community. Breastfeeding initiation is high in this community, but many people ultimately do not breastfeed for as long as they would like to. The main questions it aims to answer are: Do Latine mothers benefit from peer counseling support from peer counselors who can speak Spanish and share their cultural background? Are mothers more likely to continue exclusive breastfeeding if additional funds are given so that the WIC exclusive breastfeeding package has the same cash value as the WIC formula feeding package? Researchers will compare participants in the intervention group (who receive peer counseling and additional funds) to a control group (who do not receive peer counseling or additional funds) to see if the intervention package improves breastfeeding rates. All participants (intervention and control) will complete weekly surveys about their feeding experiences ($8 per week). Members of the research team will also take infant weight/length measurements at home (twice during the first month and then at 2, 4, and 6 months). Participants will be recruited during pregnancy and the study will last for the first 6 months after their babies are born. Participants in the intervention condition will also be matched with Spanish-speaking Latine peer counselors who will visit mothers at home regularly (weekly at the beginning of the study, monthly at the end of the study) and receive $150 for every month they select the WIC exclusive breastfeeding package. Mothers can choose to receive an electric breast pump instead of one $150 payment. |
JASMINE M DEJESUS; | 2025-03-17 |
| 83 | Maintenance-phase PROtein Requirements After RouX-en-Y-gastric Bypass Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study investigates protein requirements at least 1 year after gastric bypass surgery in adult males, to investigate whether protein requirements are elevated compared to protein requiremens for the general populaiotn. The main study outcome is the estimated average protein requirements for the study populaiton. |
BART VAN DER SCHUEREN; | 2025-03-17 |
| 84 | Intensive Dietary and Activity Counselling PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this intervention study is to investigate if a intensive dietary and physical activity counselling during the first two years of life in children with increased (genetically) risk for Type 1 Diabetes (T1D) can promote a healthy beta-cell environment, … |
HELENA ELDING LARSSON; | 2025-03-15 |
| 85 | A Randomized, Double-blind, Placebo-controlled Phase II Clinical Study to Evaluate The Efficacy and Safety of IBI362 in Subjects with HFpEF（heart Failure with Preserved EjectIon Fraction）or HFmrEF（heart Failure with Mildly Reduced Ejection Fraction）combined with Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of IBI362 in Chinese subjects with heart failure with ejection fraction retention/mild ejection fraction reduction (HFpEF/HFmrEF) combined with obesity (BMI≥28kg/㎡). This study will enroll about 141 NYHA Class II-III HFpEF/HFmrEF subjects combined with obesity. Eligible participants will be randomly assigned to IBI362 4 mg, IBI362 6 mg, or placebo at a ratio of 1:1:1, randomized by concomitant atrial fibrillation during screening (history/screening ECG). The trial period includes a 2-week screening period, a 52-week double-blind treatment period, and a 4-week safety follow-up period. |
INNOVENT BIOLOGICS SUZHOU | 2025-03-15 |
| 86 | A Phase 2b, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight, and Type 2 Diabetes Mellitus (VESPER-2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to test how well once-weekly MET097 (an ultra-long-acting GLP-1 receptor agonist) works to treat adults with obesity or overweight and type 2 diabetes mellitus (T2DM) compared to placebo. MET097 or placebo will be administered to individuals via subcutaneous injection once weekly for 28 weeks. If an individual is randomly assigned to MET097 they will receive one of four different dose regimens. |
METSERA | 2025-03-14 |
| 87 | The Impact of Low Glycemic Index Nutritional Shake on Glucose Regulation in Overweight and Obese Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Low glycemic index nutritional shakes have clinically shown to improve post-prandial glycemic responses in acute laboratory control studies. However, there is limited information on how replacing meals with low-glycemic index shake could impact glucose regulation in free-living adults consuming their own diets. The present study aims to examine the impact of adding the SP Glucose-Assist shake to the breakfast of non-diabetic overweight and obese adults. Subjects: 40 non-diabetic adults aged 25-65 years and body mass index ranging between 25-39 . Protocol: This is going to be a three-week study that will include a one-week self-selected diet, … |
STAVROS KAVOURAS; | 2025-03-14 |
| 88 | A PHASE 1, OPEN-LABEL, FIXED-SEQUENCE STUDY TO EVALUATE THE PHARMACOKINETIC INTERACTIONS BETWEEN PF-07976016 AND PF-06882961 IN OTHERWISE HEALTHY ADULT PARTICIPANTS WITH OVERWEIGHT OR OBESITY PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to see how two study medicines, PF-07976016 and danuglipron, taken together affect the level of each other in the blood of participants who have overweight or obesity. The total number of weeks of the study is up to approximately 22 weeks (5.5 months). |
PFIZER | 2025-03-13 |
| 89 | A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight. |
AMGEN | 2025-03-12 |
| 90 | Youth-onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases. Rates of type 2 diabetes have tripled in children and young adults over the last 40 years. Vascular diseases are also increasing in young people. Objective: To learn more about factors, including type 2 diabetes, that may cause vascular disease in young people. Eligibility: People aged 12 to 25 years who (1) have type 2 diabetes; (2) are overweight but not diabetic; … |
STEPHANIE T CHUNG; | 2025-03-12 |
| 91 | A School-Based Partnership with Rural Tribal Schools for The Primary Prevention of Obesity Among American Indian Youth (P2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn if a culturally relevant health promotion curricula prevents obesity among 4th graders in rural tribal schools. The main questions it aims to answer are: 1) Does the health promotion curricula intervention increase diet and physical activity behaviors in 4th grade students? Researchers will compare to 3rd grade classes who will not receive the intervention. All participants will have their skin carotenoids assessed using Veggie Meter, complete 24-hour diet recall via telephone, height and weight measured, answer two surveys about perceptions of their school environment practices and diet patterns at school. |
REGINA EDDIE; | 2025-03-12 |
| 92 | A Phase II Randomised, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Overweight or Obesity With Type 2 Diabetes Who Are on A Stable Dose of GLP-1 Receptor Agonist PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase II study is a randomized, parallel group, double blinded, placebo-controlled, multicenter to evaluate the efficacy, safety, and tolerability of AZD6234 in adults with overweight or obesity and type 2 diabetes on stable GLP-1 RA therapy. |
ASTRAZENECA | 2025-03-12 |
| 93 | The Impact of Time Restricted Eating on Type 2 Diabetes Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Time-restricted feeding limits caloric intake to active daytime hours with fasting for 14 to 16 hours. It has shown great promise as a novel intervention for stabilizing blood glucose, reducing weight, and improving cardiovascular disease outcomes. However, this approach has not been tested on people with diabetes, … |
JOSE O. ALEMAN; | 2025-03-10 |
| 94 | A Phase 2 Study to Evaluate The Efficacy, Safety, and Tolerability of TERN-601 in Adults With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2a multicenter, randomized, double-blind, placebo-controlled clinical trial studying the efficacy, safety, and tolerability of orally administered TERN-601 in adults with overweight or obesity. |
TERNS | 2025-03-07 |
| 95 | Advancing ADPKD Treatment With GLP-1RA: A Study of Glucagon-Like Peptide-1 Receptor Agonists’ Efficacy, Safety, and Mechanism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed clinical trial aims to assess if a year of treatment with a glucagon-like peptide 1 receptor agonist, a medication approved for weight management that also improves the body’s response to glucose and insulin, can slow kidney growth in adults with autosomal dominant polycystic kidney disease who are overweight or obese. The study will also evaluate changes in abdominal fat and kidney metabolism using cutting-edge images techniques. Blood and urine samples will provide further insight into biological changes that may be linked to the benefits of the intervention, while ensuring careful monitoring of safety and tolerability. |
KRISTEN NOWAK; | 2025-03-06 |
| 96 | A Phase 4, Prospective, Open-Label, Single-Arm Study to Assess The Effectiveness of Tirzepatide After Initiation of Ixekizumab in Adult Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe PsA and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months. |
ANDREW SHAROBEEM; | 2025-03-06 |
| 97 | A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Retatrutide Treatment in The Maintenance of Weight Reduction in Individuals With Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss. The study will have two treatment phases: an 80 week lead-in phase in which all participants will take retatrutide dose 1 and a 36 week randomized, double-blinded phase in which participants will either take retatrutide dose 1, retatrutide dose 2, or switch to placebo. Participation in the study will last around 125 weeks. |
WAYNE HO; | 2025-03-05 |
| 98 | A Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending and Multiple Ascending Dose Study to Assess The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HCR-188 in Overweight or Obese Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a first-in-human study evaluating the safety, tolerability, pharmacokinetics, immunogenicity and pharmacodynamics of single and multiple doses of HCR-188 administered as subcutaneous injection(s). |
HELICORE BIOPHARMA | 2025-03-04 |
| 99 | A Phase 1 Randomized, Double-Blind, Placebo Controlled. Single and Multiple Ascending Dose Study to Investigate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MET233 Co-administered With MET097 in Adult Participants With Obesity or Overweight Including Participants With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to test how well the combination of MET233 with MET097 works to treat individuals with obesity or overweight with or without diabetes. |
METSERA | 2025-03-03 |
| 100 | Exploring The Effects of Time-Restricted Feeding on The Immune Function of Obese Individuals: A Multi-Omic Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized trial is to: 1) investigate the immunological landscape of patients with obesity and conduct an in-depth functional characterization of their immune system; and 2) precisely define the effects of time-restricted feeding (TRF) on immune function in patients with obesity; 3) define the immunomodulatory properties of white adipocytes in response to TRF, … |
HOSPITAL UNIVERSITARI VALL D’HEBRON RESEARCH INSTITUTE | 2025-03-03 |
| 101 | Hyperglycemia Induced Hyperexcitability: A Novel Role for KATP in The Progression of Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Insulin is a hormone that is made by β-cells in the pancreas and when released into the bloodstream helps control blood sugar levels. Insulin release is regulated by electrical activity in the β-cell which is generated by the ATP-sensitive potassium (KATP) channel. While reduced KATP activity is associated with increased insulin secretion, animals lacking KATP exhibit reduced secretion. This crossover from hypersecretion to undersecretion with KATP loss mirrors insulin secretion during type 2 diabetes. Intriguingly, … |
NATHANIEL YORK; | 2025-03-03 |
| 102 | A Phase 1, Randomized, Double-blind, Placebo-controlled Study of The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Dose ALN-4324 in Overweight to Obese Adult Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and tolerability of single ascending doses of ALN-4324 in healthy volunteers and to characterize the single-dose PK of ALN-4324. |
ALNYLAM PHARMACEUTICALS | 2025-03-03 |
| 103 | Sarcopenic Obesity: Estimation of Prevalence and Identification of Clinical and Biological Determinants in A Cohort of Adult Obese Patients and Longitudinal Follow-up PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Context: Obesity, defined as excessive body fat, can lead to disability and loss of autonomy. If there is concomitant quantitative and qualitative muscle loss, sarcopenic obesity (SO) is suspected in this context. Although this clinical entity was defined several years ago, it is only very recently that precise assessment criteria have been established for screening and diagnosing this pathology (Donini et al. 2022). Defined by the ESPEN/EASO consensus, SO has various consequences for health, particularly in terms of mobility and worsening of co-morbidities. It is therefore necessary to screen for SO, … |
YVES BOIRIE; | 2025-03-01 |
| 104 | Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to learn how a weight loss medication called semaglutide, which is used to treat obesity, in addition to standard AF treatment might affect AF, atrial fibrillation severity, and whether it changes the risk of atrial fibrillation recurring after standard AF treatments. |
SILVANA PANNAIN; | 2025-03-01 |
| 105 | The Role of Perirenal Fat As Predictor in Diabetic Nephropathy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1 detect the relationship between perirenal fat thickness (PrFT) and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes (T2DM). 2)Explored the relationship between PRF thickness and the onset and progression of albuminuria in patients with diabetes 3)Evaluate associations between obesity-related markers with albuminuria and advanced kidney disease in patients with type 2 diabetes mellitus (DM) |
MARINA SOBHY GERGES; | 2025-03-01 |
| 106 | Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, pragmatic, 21 month, single-center, randomized, 2-phased, open-label, parallel-group trial comparing the use of enhanced lifestyle changes (ELC) in two different sequential anti obesity medication (AOM) therapies. The ELC consists of a medically-supervised and comprehensive weight loss program (Cleveland Clinic’s Department of Endocrinology, Diabetes and Metabolism’s Integrated Weight Management Program). In the first phase (9 months) of the study, all participants will receive tirzepatide 15 mg (option #1) or semaglutide 2.4 mg if tirzepatide is not tolerated. In the second phase, after completing 9 months of tirzpeatide or semaglutide, … |
BARTOLOME BURGUERA; | 2025-03-01 |
| 107 | Prevalence, Determinants and Consequences of Dyspnea During Weaning in Critically Ill Obese Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: ICU patients encounter numerous discomforts, with dyspnea (the sensation of breathlessness) being among the most distressing and impactful. Unlike pain, dyspnea in ICU settings has historically received limited attention, despite its severe psychological impact. ICU clinicians often use assessment tools like the simple numerical dyspnea scale (Dyspnea-VAS) and the Respiratory Distress Observation Scale (MV-RDOS) to measure dyspnea. These scales are also utilized during the weaning process, an essential phase when patients attempt to breathe independently without ventilator assistance. Weaning is crucial for ICU patients, as delayed or unsuccessful extubation increases the risk of complications and mortality. Obese ICU patients, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-03-01 |
| 108 | COMPARISON OF THE EFFICACY OF ONE LEVEL AND TWO LEVEL OF BILATERAL THORACIC ERECTOR SPINAE PLANE BLOCK COMBINED WITH GENERAL ANESTHESIA IN LAPAROSCOPIC BARIATRIC SURGERY FOR OBESE PATIENTS: RANDOMIZED CONTROLLED TRIAL PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is to evaluate effectiveness of one-level versus two-level thoracic ESP block on intraoperative and postoperative analgesia in bariatric surgeries and to compare total opioid consumption of both groups. |
BELAL GALAL MOSTAFA MOHAMMED KHATER; | 2025-03-01 |
| 109 | The Effects of Tirzepatide Use on Muscle and Vascular Function Among Obese Older Hispanic Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity and type 2 diabetes mellitus (T2DM) represent major public health concerns in the aging Hispanic community. Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist recently approved for the treatment of T2DM and obesity has been shown to be effective at reducing weight, improving markers of T2DM control, and improving cardiovascular health. Utilization of tirzepatide in the Hispanic community has been on the rise since FDA approval was issued, … |
SHREYA RAO; | 2025-03-01 |
| 110 | CHOICE to AVOID or RESIST: Evaluating Participants’ Choice of Self-regulatory Strategy on Weight Management Outcomes: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trials will formally test whether participants’ active choice of self-regulatory strategies (AVOID or RESIST) leads to greater adherence to weight management strategies by comparing the CHOICE arms to the randomized arms of the parent intervention, AVOID/RESIST (IRB STUDY00001652: AVOID-RESIST). |
SARAH SALVY; | 2025-03-01 |
| 111 | Effect of Nutrigenetic Intervention on Cardiovascular Biomarkers, Oxidative Stress and Antioxidant Capacity in Subjects with Abdominal Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Abdominal obesity (AO) is a multifactorial disease that affects 81.6% of the Mexican population; it is characterized by the excessive accumulation of adipose tissue in abdominal region. Scientific evidence suggest that regional fat distribution plays a critical role in the development of cardiovascular diseases (CVD). The main processes involved in the increased risk of developing CVD in the presence of AO are alterations in insulin signaling, dyslipidemias, atherosclerosis, inflammation, and oxidative damage. On the last years has been reported genetic variations associated with AO and dyslipidemia. In addition, … |
ERIKA MARTINEZ-LOPEZ; | 2025-03-01 |
| 112 | Efecto De La Suplementación De Vitamina D En La Resistencia A La Insulina En Escolares Y Adolescentes Con Obesidad PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Vitamin D deficiency is commonly observed in patients with obesity, primarily due to sequestration by adipose tissue. Recent research highlights the importance of this deficiency, showing a correlation between low vitamin D levels and mechanisms contributing to insulin resistance. Objectives: This study aims to compare the effects of supplementing with 4,000 IU of vitamin D versus 1,000 IU over six months on insulin resistance and the leptin/adiponectin ratio in school-aged children and adolescents with obesity. Materials and Methods: A controlled clinical trial will be conducted involving 40 children with obesity aged 10 to 18 years (BMI \>95th percentile). Participating children and their parents will undergo measurements such as weight, height, BMI, body fat, and Tanner stage. All participants will receive dietary and physical activity recommendations based on WHO guidelines. After initial assessments, participants will be randomly assigned to receive either 4,000 IU or 1,000 IU of vitamin D. They will be monitored monthly for capsule intake and adverse effects, with follow-up measurements of anthropometry, leptin, adiponectin, insulin \& lipid profile. Statistical Analysis: Baseline characteristics will be compared using t-Student or U-Mann Whitney tests, depending on variable distribution. The intervention’s impact will be assessed by calculating deltas for body fat and biochemical measurements, with significance tested using paired t-tests or Wilcoxon tests. Covariance analysis (ANCOVA) will be used to adjust for confounding variables. |
COORDINACIÓN DE INVESTIGACIÓN EN SALUD MEXICO | 2025-03-01 |
| 113 | The Efficacy and Safety of Herbal Medicine Treatment for Obese Patients with Spinal and Joint Pain: A Pragmatic Randomized Controlled Pilot Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a pragmatic pilot randomized controlled trial aimed at investigating the effectiveness of herbal medicine treatment for obese patients with spinal and joint pain, using a control group receiving lifestyle guidance. |
IN-HYUK HA; | 2025-03-01 |
| 114 | Childhood Obesity Is A Global Health Issue, Especially in Children with Trisomy 21 (T21), Who Face Higher Risks of Non-alcoholic Fatty Liver Disease (NAFLD). Early Detection Using Non-invasive Tools Like Liver Elastography Is Key. Evaluating Dietary Patterns with The 24-hour Food Recall and KIDMED Helps Guide Personalized Interventions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood obesity is a growing public health issue affecting millions of children worldwide, increasing the risk of metabolic and cardiovascular diseases in adulthood. This problem is particularly concerning in children and adolescents with Down syndrome (trisomy 21, T21), who have a higher predisposition to fat accumulation due to genetic, metabolic, and behavioral factors. However, assessing their nutritional status and body composition is challenging, … |
LORENA LOPEZ LORA; | 2025-03-01 |
| 115 | JOULE – Metabolic Adaptation to Weight Loss in Response to A Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity – A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity. Behavioural lifestyle intervention with and without a pharmacological intervention – semaglutide- will be studied. Study participants will be randomized to one of two groups. Group A will follow a behavioral lifestyle program (BLP) alone for 6 months, followed by BLP and treatment with semaglutide for six months. Group B will be enrolled in BLP and semaglutide from baseline to 6 months. The primary research question will assess, … |
KATHERINE M MORRISON; | 2025-03-01 |
| 116 | The Effects of Tirzepatide in Young Adults With Prader-Willi Syndrome, Hypothalamic Obesity and General Non-Syndromic Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research study is comparing the effectiveness of a weight loss medication called Tirzepatide in young adults with Prader-Willi Syndrome and/or hypothalamic obesity, as compared to young adults with obesity that is unrelated to a genetic syndrome or underlying medical cause. These groups will be given medication for 1 year to see how weight and other health factors are effected by the medication. |
GRACE KIM; | 2025-03-01 |
| 117 | Sulforaphane-Smart® on Lipid and Glucose Metabolism, Inflammation, Adiposity and Microbiome of Overweight Adults SANO PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Sulforaphane-Smartt® formula is a pill, patented by the company INGREDALIA, prepared with broccoli by-products which have been concentrated and enriched in glucosinolates/isothiocyanates (GLS/ITCs). The goal of this intervention study with the Sulforaphane-Smartt® formula is to study the bioavailability of the bioactive compounds in normal weight and overweight adults. The main questions it aims to answer are: * Determine the absorption curve of the bioactive compounds (GLS/ITCs). * Analyze the metabolites in plasma and urine of the GLS/ITCs to know the bioavailability. This acute intervention is designed to take a single fasting dose of Sulforaphan-Smart®, … |
Mª JESÚS PERIAGO; | 2025-03-01 |
| 118 | Intervention INC: An Interactive Family-centered MHealth Tool to Reduce Obesity Risk in Urban Minority Preadolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Using a two-group randomized study design, this study aims to evaluate the effectiveness of the adapted family-centered mHealth tool on child BMI z-score (primary outcome), child dietary behaviors, and parental feeding practices, from baseline to 12-month follow-up, among 200 child-parent dyads. It is hypothesized that children in the experimental group will demonstrate larger BMI-z score improvements between baseline and 12-month follow-up compared to children in the comparison group. |
TUFTS UNIVERSITY | 2025-02-27 |
| 119 | The Effect of Symbiotic Beverage Consumption on Lipid Profile and Nutritional Status in Overweight and Hypercholesterolemia Adults Aged Above 18 Years PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate whether the synbiotic beverage Daygurt can improve lipid profiles, blood sugar levels, blood pressure, and body weight in individuals diagnosed with dyslipidemia. The main questions it aims to answer are: Does Daygurt significantly reduce total cholesterol and LDL levels compared to nutrition counseling alone? Does Daygurt increase HDL levels and reduce triglycerides more effectively than nutrition counseling? Does Daygurt lead to greater improvements in fasting blood sugar, blood pressure, … |
POLITEKNIK KESEHATAN KEMENKES PADANG | 2025-02-27 |
| 120 | A Phase I Clinical Trial to Evaluate The Safety, Tolerability, and Pharmacokinetic of SYH9017 in Chinese Participants With Overweight and Obesity Following Single and Multiple Doses PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, single-center, dose-escalation, single ascending dose and multiple ascending dose study of SYH9017 in Chinese participants with overweight and obesity. |
CSPC BAIKE SHANDONG BIOPHARMACEUTICAL | 2025-02-27 |
| 121 | Evaluation of The Achievement of A Pharmacodynamic Target of Piperacillin-Tazobactam for The Population with Obesity: An Open Randomized Controlled Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the feasibility of an open randomized controlled study which would assess the proportion patients with obesity who will have a favorable pharmacodynamic parameter (i.e. fT\> 100% MIC) after 24 hours of piperacillin-tazobactam administered as a prolonged intermittent infusion compared to a standard infusion. |
BENOIT CREVIER; | 2025-02-26 |
| 122 | A Study on Application of Adjustable Headrest in Painless Curettage Surgery for Overweight and Obese Patients: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to observe the effect of adjustable headrests on ventilation function in overweight and obese patients through clinical experiments, and to explore the impact on the incidence of hypoxemia during painless curettage in overweight and obese patients. Participants will be randomly allocated to three groups: the supine head-straight position group(Group A), the supine head-lateral position group(Group B), and the adjustable headrest group(Group C). These three groups of patients underwent painless curettage surgery in the daytime operating room and the occurrence of hypoxemia will be observed. |
LI NA; | 2025-02-25 |
| 123 | A Proof of Concept, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Effects of Tradipitant on Nausea and Vomiting After GLP-1R Agonist Administration in Healthy Overweight Class I or Class II Obese Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to measure the effects of using Tradipitant after GLP-1R agonist use on nausea and vomiting in healthy overweight, class I, or class II obese volunteers. The study is placebo-controlled with two treatment arms. |
VANDA PHARMACEUTICALS | 2025-02-25 |
| 124 | Pennington Generation Cohort PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The Pennington Generation Cohort is an observational study comprised of Louisiana families. Families will be assessed at baseline for a variety of traits and behaviors, and then followed up over time to try to understand the role of lifestyle and the environment on the risk of developing obesity and other health outcomes. |
PETER T. KATZMARZYK; | 2025-02-24 |
| 125 | Effects of Exercise Snacks and Sprint Interval Training on Cardiovascular Function in Overweight Adults: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Exploring the efficacy and acceptability of exercise snacks (ES) and sprint interval training (SIT) could provide time-efficient, low-barrier alternatives for individuals, especially those who, due to ‘lack of time, environment, and equipment,’ struggle to meet traditional physical activity recommendations. This research aims to investigate the effects of ES and SIT, of equal exercise volume, on overweight adults. |
BEIJING SPORT UNIVERSITY | 2025-02-24 |
| 126 | The Dose Trial: Dose Intensity of Behavioral Interventions for Childhood Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The research team is recruiting 900 children between the ages 5-17 with obesity from Tennessee and Louisiana. The team is assigning children and their caregivers by chance to one of five groups. In the first group, 300 children and their caregivers receive 26 hours of IBT. In the second group, 300 children and their caregivers receive 13 hours of IBT. The remaining three groups of 100 children and their caregivers receive 16, 19, or 22 hours of IBT. Children’s healthcare providers, nutritionists, … |
BILL HEERMAN; | 2025-02-20 |
| 127 | A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety and Tolerability of Co-administration of AZD9550 and AZD6234 in Participants Living With Obesity or Overweight With Co-morbidity (ASCEND) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether treatment with AZD9550 when given in combination with AZD6234 as once weekly subcutaneous (SC) injections is superior to placebo or either agent administered as monotherapy for weight loss in participants living with obesity or overweight with at least one weight-related co-morbidity. |
ASTRAZENECA | 2025-02-18 |
| 128 | Effect of Low Valine Diet on Body Weight and Metabolic Parameters PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to explore the effects of ordinary meal replacements and low-valine meal replacements on the weight and risk of related metabolic diseases in overweight/obese patients through a randomized double-blind controlled clinical trial. |
SHANGHAI ZHONGSHAN HOSPITAL | 2025-02-18 |
| 129 | A Phase 1, Double-blind, Two-arm, Mechanism of Action Study to Investigate The Effect of Orforglipron on Body Composition in Adult Participants With Obesity or Overweight, Without Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to see how orforglipron affects the amount of body fat compared with placebo in participants with obesity or overweight. Participation in the study will last approximately 8 months. |
ELI LILLY | 2025-02-17 |
| 130 | Hepatic Elastography-Enhanced Lifestyle Modification in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The 2022 National Health Survey in Thailand revealed a substantial rise in obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The prevalence of MASLD was 19.7%, with higher rates observed in individuals with metabolic syndrome and diabetes. Effective management of MASLD primarily involves lifestyle modifications, including dietary adjustments and increased physical activity. Evidence suggests that patients unaware of their liver fibrosis status are less likely to adhere to these interventions. This study aims to evaluate the impact of hepatic elastography monitoring on lifestyle modification adherence and health outcomes in patients with MASLD over 48 weeks. |
PHUNCHAI CHARATCHAROENWITTHAYA; | 2025-02-17 |
| 131 | A Novel Precision Medicine Approach for Obesity: A Randomized, Multi-Center Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to assess the efficacy of a saliva- based biomarker to predict response to semaglutide for the treatment of obesity. |
ANDRES J. ACOSTA; | 2025-02-15 |
| 132 | Effects of Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Overweight and Obese Children With Down Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Down syndrome (DS) is caused by trisomy 21, or the presence of an extra copy of chromosome 21. A calibrated weight scale is used to measure participants’ weight accurately. A stadiometer measures participants’ height to the nearest millimeter. A flexible non-stretchable waist circumference tape is used to assess abdominal obesity. Body mass index (BMI, ratio of height and weight, expressed as kg/m2 6-Min Walk is a test to evaluate aerobic fitness level. Brisk Walk, … |
JANNAT ARSHAD; | 2025-02-15 |
| 133 | Mothers and CareGivers Investing in Children: MAGIC 2.0 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will use a longitudinal, randomized control trial design to determine intervention impact on parent and child behaviors, and infant health. The two intervention groups include: 1) MAGIC-FEED+; and 2) MAGIC-SAFE. This trial is an efficacy trial of the MAGIC-FEED and MAGIC-SAFE program that has been successfully implemented with families as part of the MAGIC 1.0 program trial (IRB#: 2015040017). * The primary aim is to investigate each intervention’s impact on infant BMIZ at 13 months. * The investigators will also assess the effect of MAGIC-FEED on caregiver nutrition knowledge and feeding practices, responsive feeding, infant diet, … |
ELIZABETH WIDEN; | 2025-02-13 |
| 134 | The Impact of Pre-Pregnancy Weight Loss on Infant Sucking Behavior in Response to A Challenging Nipple PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will help researchers learn more about how babies respond to bottle nipples with larger or smaller holes. Researchers guess that infants of mothers with obesity who did not lose weight prior to pregnancy will have the greatest Suck Effect on the challenging compared with the typical nipple. |
AMANDA KINNEY CRANDALL; | 2025-02-13 |
| 135 | EFFICACY and SAFETY of GZR18 INJECTED EVERY 2 WEEKS (Q2W) in PARTICIPANTS WITHOUT TYPE 2 DIABETES, WHO HAVE OBESITY or ARE OVERWEIGHT: A RANDOMIZED, TIRZEPATIDE- and PLACEBO-CONTROLLED STUDY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2 study to evaluate the safety and efficacy of 24, 36, and 48 mg GZR18 (Q2W) compared with placebo and 15 mg tirzepatide (QW). The study will evaluate weight management in participants with obesity (BMI ≥30 kg/m2) or who are overweight (BMI ≥27 kg/m2) with weight-related comorbidities (excluding type 2 diabetes mellitus). |
GAN AND LEE PHARMACEUTICALS USA | 2025-02-12 |
| 136 | The PILI ‘Āina Project PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Native Hawaiians’ traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators will adapt and test an evidence-based multilevel intervention entitled PILI ‘Āina to improve the self-management of prevalent cardiometabolic diseases and reduce risk factors for developing new diet-related illnesses and implement and evaluate the impact and sustainability of community-wide cooking demonstrations. The objectives of this project are to optimize the effectiveness and sustainability of PILI ‘Āina, improve diet quality, cardiometabolic markers, … |
CLAIRE ING; | 2025-02-12 |
| 137 | The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF. |
UNIVERSITY OF LEICESTER | 2025-02-12 |
| 138 | Cissus Quadrangularis (CQR-300®) and Dichrostachys Glomerata (Dyglomera®) Extracts Increase GLP-1 Levels and Inhibit Dipeptidyl Phosphate-4 Activity in Healthy Overweight and Obese Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is a global health crisis affecting over 2.3 billion individuals worldwide. This prospective study aims to evaluate the comparative effects of Cissus quadrangularis (CQR-300) and Dichrostachys glomerata (Dyglomera™) extracts on obesity-related parameters, focusing on their impact on glucagon-like peptide-1 (GLP-1) levels and dipeptidyl peptidase-4 (DPP-4) enzyme activity in obese subjects. Parameters such as GLP-1 levels, DPP-4 activity, food intake, body weight, blood lipids, fasting blood glucose, and visceral fat mass will be measured at baseline and various intervals. In our previous pre-clinical trial involving 18 adult male Wistar rats (150-200 g), … |
JULIUS OBEN; | 2025-02-12 |
| 139 | Investigation of Safety, Tolerability and Pharmacokinetic Properties of Multiple Oral Doses of NNC0487-0111 in Chinese Participants With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is testing a new study medicine called NNC0487-0111 for weight control in Chinese people with Body mass index (BMI) greater than or equal to (\>=) 24 kilogram per square meter (kg/m\^2). The aim of this study is to find out how safe the study medicine is and how it behaves in your body. Participants will either get NNC0487-0111 or placebo. Which treatment participants will get is decided by chance. Oral NNC0487-0111 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. The study will last for about 60 days. |
NOVO NORDISK | 2025-02-09 |
| 140 | BfedBwell: Multiphase Optimization Strategy Pilot Trial of A Nutrition Intervention for Cancer Survivors With Overweight and Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Using the Multiphase Optimization Strategy (MOST) framework, an engineering-based approach to efficiently and systematically develop, optimize, and evaluate behavioral interventions, this study will test three components: (1) 1:1 counseling with a registered dietitian, (2) behavioral skills development, and (3) group support for delivery alongside a core nutrition curriculum within a clinical exercise oncology program. |
EMILY B HILL; | 2025-02-05 |
| 141 | Tirzepatide for Individuals With Comorbid Obesity and Methamphetamine Use Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label pilot study to evaluate the feasibility and preliminary efficacy of using tirzepatide when prescribed for its United States (US) Food and Drug Administration (FDA)-approved weight-related indication in individuals with comorbid methamphetamine use disorder. |
MANISH JHA; | 2025-02-03 |
| 142 | Carotid Atherosclerosis Screening: Epidemiological Profile and Preventive Intervention PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Title of the study: Carotid Atherosclerosis Screening: Epidemiological Profile and Preventive Intervention. Objective: The main objective of this study is to characterize and identify the prevalence of carotid atherosclerosis in adults who are still asymptomatic for vascular disease and to evaluate the impact of detecting carotid atherosclerosis on preventive strategies. The study covers a population of approximately 4,780 patients. Estimated Duration of the Project: The estimated duration of the project is 36 months, starting in February 2025, … |
UNIVERSIDADE DO PORTO | 2025-02-01 |
| 143 | A Single-center, Single-dose, Randomized, Open-label, Single-period, Parallel Bioequivalence Study of HRS9531 Injection Solution in Multi-dose Pens and Single-dose Pens in Overweight/Obese Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being conducted to evaluate the bioequivalence between a single-dose pen and a multi-dose pen of HRS9531 injection solution. |
QING WEN; | 2025-02-01 |
| 144 | Obesity Prevention Program for Overweight and Obese Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood overweight and obesity are defined as crises that adversely affect health and well-being, pave the way for various health problems in the future, and are increasingly prevalent worldwide. Obesity is a significant public health issue as it predisposes children and adolescents to lifelong diseases and contributes to increased mortality and morbidity in adulthood. Eating behavior irregularities and excesses during childhood and adolescence lead to deteriorating health and rising obesity incidence. This condition causes significant issues in the respiratory, endocrine, cardiovascular, digestive, and orthopedic systems while also creating psychological effects, … |
ADEM SÜMEN; | 2025-02-01 |
| 145 | Acute Physiological Responses to Isoenergetic High-Intensity Interval Vs. Moderate-Intensity Continuous Exercise in Overweight or Obese Young Females: Focus on Catecholamines, Oxygen Consumption, Lipid Utilization, and Appetite Regulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases. Managing obesity effectively requires lifestyle and dietary modifications, including increased physical activity. Among the various exercise strategies, Moderate-Intensity Continuous Training (MICT) and High-Intensity Interval Training (HIIT) are widely recommended for reducing FM. Compared to MICT, HIIT is a time-efficient approach, often perceived as more enjoyable, and has been shown to promote greater total and abdominal fat loss in a shorter period. However, … |
LABORATOIRE DES ADAPTATIONS MÉTABOLIQUES À L’EXERCICE EN CONDITIONS PHYSIOLOGIQUES ET PATHOLOGIQUES | 2025-02-01 |
| 146 | Comparison Between The Effects of Low-Dose Semaglutide With Metformin Vs. Metformin Alone Over Metabolic Profile in Obese Polycystic Ovary Syndrome: A Phase II Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that is frequently associated with metabolic features, including obesity. Improvement of metabolic manifestations helps in the control of symptoms, including subfertility. Metformin has been commonly used to decrease insulin resistance and weight in PCOS patients suffering from obesity. Glucagon-like peptide (GLP-1) agonist semaglutide is also effective in managing different metabolic features, … |
MA HASANAT; | 2025-02-01 |
| 147 | EFFECT of PYRAMIDAL TRAINING on EPICARDIAL FAT for CORONARY ARTERY DISEASE PREVENTION PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To show the effect of pyramidal training for coronary artery disease prevention on: -Epicardial fat, BMI, Waist circumference (WC), Lipid profile, Quality of life and Mediterranean Diet Adherence. |
CAIRO UNIVERSITY | 2025-02-01 |
| 148 | Comparative Study Between Efficacy of Ultrasound-Guided Bilateral Erector Spinae Plane Block and Thoracic Paravertebral Block on Perioperative Analgesia and Fast Recovery of Patients Undergoing Laparoscopic Sleeve Gastrectomy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to compare the efficacy of ultrasound-guided bilateral erector spinae plane block and thoracic paravertebral block on perioperative analgesic control for 24 hours postoperative and fast recovery of patients undergoing laparoscopic sleeve gastrectomy using the Visual Analogue Scale. |
ALAA MOHAMED AHMED AHMED; | 2025-02-01 |
| 149 | Observational Study of Patients Being Treated With Anti-obesity Medication PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the real-world effects of selected obesity medications in adults undergoing medical weight management. The main outcomes of interest are changes in body composition, routine clinical markers, muscular performance, and nutritional intake over the course of treatment. Additionally, the influence of lifestyle factors on changes in these outcome variables will be examined. Participants beginning treatment with selected obesity medications will undergo periodic body composition and muscular performance testing, as well as complete online surveys about their nutritional intake and physical activity and exercise participation. Additionally, … |
TEXAS TECH UNIVERSITY | 2025-01-31 |
| 150 | A Phase 1, Randomized, Double-blind, Placebo-controlled Study of Ascending Doses of WVE-007 to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Adults Living with Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of WVE-007 when administered subcutaneously (SC) as single ascending doses in adults who are affected by overweight or obesity. |
WAVE LIFE SCIENCES | 2025-01-31 |
| 151 | ABC (Additional Betaine and Choline) Study: Effect of Betaine and Choline Intake on Biomarkers of Metabolic Health in Humans PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to determine whether extra betaine and choline influence metabolic health in adults with overweight and obesity. |
CLARA CHO; | 2025-01-31 |
| 152 | Inflammation: A Key Contributor to Heart Disease and Diabetes? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate the inflammatory response associated with cardiometabolic diseases, and whether these can be reduced by ex vivo treatment with therapeutic agents. Briefly, … |
EMMA BÖRGESON; | 2025-01-30 |
| 153 | Tailoring One-Anastomosis Gastric Bypass Based on Total Small Bowel Length – A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Scientific Background and Rationale One-Anastomosis Gastric Bypass (OAGB) is the most common bariatric surgery in Israel, demonstrating effective and sustained weight loss, improvement in obesity-related comorbidities, and a relatively low failure rate. The procedure involves creating a long gastric pouch and an anastomosis with a segment of the small intestine, bypassing a portion of the digestive tract. The length of the biliopancreatic limb (BPL) significantly influences metabolic outcomes, with a longer BPL associated with greater weight loss and metabolic improvements. However, the optimal BPL length remains debated, as excessive length can lead to malabsorption, … |
SHMUEL KIVITY; | 2025-01-29 |
| 154 | MOnitoring NUtritional COnsequences of Obesity Treatment on Women’s Health and Transgenerational Effects for Healthier Future Generations: A Multicentre Prospective Observational Cohort Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the long-term effect of obesity treatments on the health of women. This study will specifically focusses on the effects on nutritional intake, nutritional status, musculoskeletal health and reproductive health. Additionally, this study will also investigate the effect of obesity treatment on pregnancy outcomes and child development. To achieve the goal of this study, participants already receiving either surgical treatment for obesity or treatment with anti-obesity medication as part of their regular medical care will fill in additional questionnaires, provide blood, urine and feces samples, … |
AGNES BERENDSEN; | 2025-01-28 |
| 155 | A Phase 2 Study of Once-Daily RGT001-075 Compared With Placebo in Participants Who Have Obesity or Are Overweight With Weight-Related Comorbidities (COMO-1) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2, 36-week randomized, double-blind, placebo-controlled, parallel arm study that will evaluate the safety, tolerability, weight loss efficacy, pharmacodynamic effects, and pharmacokinetics of RGT001-075 in adults who are obese (BMI ≥30 kg/m²) or who are overweight (BMI ≥27 kg/m²) with at least one weight-related comorbidity. RGT001-075 or matching placebo will be administered once daily. |
REGOR PHARMACEUTICALS | 2025-01-24 |
| 156 | Additional Daily Intake of Eggs for Improving Metabolic Outcomes and Choline Levels in Individuals with Obesity: Phase I Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to determine the effect of additional daily egg intake on metabolic phenotypes and metabolism in the context of obesity. |
CLARA CHO; | 2025-01-24 |
| 157 | Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop an evidence-based precision medicine approach for obesity that enhances weight loss and promotes weight loss maintenance. |
ANDRES J. ACOSTA; | 2025-01-22 |
| 158 | F!reF!ghterF!t: A Randomized Controlled Trial of Lifestyle Coaching Interventions for Obese Firefighters PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our goal is to explore the effectiveness of 9- month lifestyle medicine based coaching intervention (individual and group coaching) versus control (usual care/ written health instructions). The primary study outcomes will be mean changes in body composition metrics . Secondary outcomes will be the prevalence of metabolic abnormities, progression/regression of Metabolic Syndrome, push-up \& sit/stand capacity, self-reported physical activity, and quality of life/diet/sleep measures. |
CAMBRIDGE HEALTH ALLIANCE | 2025-01-21 |
| 159 | Effects of ENavogliflozin on Coronary MicroVascular and Cardiac Function in Patients with ObesitY (ENVY) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to analyze the effects of enavogliflozin on heart function and coronary microvascular function in obese patients compared to a placebo, and to evaluate the improvement in cardiopulmonary exercise capacity in these patients. |
SEONG-MI PARK; | 2025-01-20 |
| 160 | A Randomized, Double-Blind, Dose-Escalation, Placebo-Controlled Phase I Clinical Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Subcutaneous Injections of HRS-4729 Injection in Healthy Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-4729 injection in healthy subjects. |
QING WEN; | 2025-01-16 |
| 161 | INTERMEDIATE-SIZE PATIENT POPULATIONS EXPANDED ACCESS to TREATMENT for SARCOPENIC OBESITY Related Papers Related Patents Related Grants Related Experts View Highlight: The expanded access is designed for patients requesting the treatment, and whose medical condition may benefit from treatment, but are unable to participate in any other IMM01-STEM clinical trial in their physician’s opinion for reasons that include: (1) They do not meet enrollment criteria, or (2) They cannot perform the assessment of outcomes, or (3) The trial site is not geographically accessible. |
IMMUNIS | 2025-01-14 |
| 162 | Effectiveness of Tailored Multichannel Interventions on Weight Loss Among Adolescents: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: overweight among adolescents is a public health issue. However, several weight loss interventions were developed and conducted for adolescents. These interventions are often not adequately tailored to the needs of this vulnerable target group. Besides, these interventions proposed one channel is adequate to deliver the message to adolescents. The proposed study aims to evaluate the effectiveness of tailored multichannel interventions on weight loss among adolescents. The proposed study is a prospective, … |
MAHMOUD AHMED AHMED AHMED ELSHEIKH; | 2025-01-12 |
| 163 | Effects of D-Chiro-Inositol Combined with Metformin on Insulin Resistance in People with Overweight or Obesity and Type 2 Diabetes Mellitus: A Placebo-controlled Randomized Double-Blind Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the efficacy of D-Chiro-Inositol (DCI) as an add-on therapy to metformin in improving insulin resistance, measured by the HOMA index, in people with overweight or obesity and type 2 diabetes mellitus (T2DM). Secondary outcomes include glycemic variability, indirect calorimetry, respiratory quotient, and other metabolic parameters. |
SILVIA MANFRINI; | 2025-01-10 |
| 164 | A Randomized Pilot Study of Produce Prescription Programs in Adults With Overweight or Obesity Experiencing Nutrition Insecurity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to understand the best practices for implementing produce prescriptions among adults with overweight or obesity experiencing nutrition insecurity. Enrolled participants will receive an 8-week intervention aimed at increasing nutrition knowledge, self-efficacy for healthy eating, and barriers to healthy food access. Participants will be randomly assigned to one of two produce prescription implementation strategies: Program 1: Participants will receive weekly produce vouchers that are redeemable at a local vendor. Program 2. Participants will receive fresh produce delivered directly to the participant’s home. These boxes will be tailored based on household size, cooking and preparation preferences, … |
HAILEY MILLER ASSISTANT PROFESSOR; | 2025-01-08 |
| 165 | A Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VTX3232 Alone or in Combination With Semaglutide in Participants With Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to understand if taking VTX3232 alone or in combination with semaglutide is safe in participants diagnosed with Obesity. Approximately 160 patients will take VTX3232 Dose A, Placebo, VTX3232 Dose A in combination with semaglutide, or Placebo in combination with semaglutide. This study consists of a 30-day Screening Period (to see if a participant qualifies for a study), a 12-week double-blind treatment period (a participant receives VTX3232 Dose A, Placebo, VTX3232 Dose A in combination with semaglutide, or Placebo in combination with semaglutide), … |
ZOMAGEN BIOSCIENCES | 2025-01-07 |
| 166 | Optimizing Fitness: Post Bariatric Surgery With Modified Qigong Breathing Exercise PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bariatric surgery has been reported to be the most effective treatment option for losing and maintaining body weight and improving comorbidities and mortality associated with morbid obesity. Nevertheless, even though physical activity is recommended to optimize bariatric surgery results. Very little is known, about whether engaging in an exercise program after surgery can provide additional improvement in health outcomes. While to date there are relatively few researches studied the effect of exercise in patients who have undergone bariatric surgery. This study was conducted to explore the influence of Modified Qigong Breathing Exercise on pulmonary function, … |
MTI UNIVERSITY | 2025-01-05 |
| 167 | Effectiveness of The Addition of Yoga to A Behavioral Weight Loss Intervention for Adults With Overweight or Obesity (MOVE for Health) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn whether adding yoga exercise to a behavioral weight loss intervention improves weight loss in adults with overweight or obesity. It will also provide information about whether this approach to weight loss has additional benefits on other health and fitness measurements. The main questions it aims to answer are: * Is there a difference in weight loss between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in how much physical activity is completed between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in the change in body composition (fat mass, lean body mass) between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in the change in cardiorespiratory fitness the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in the change in muscle strength between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in the change in resting blood pressure between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in the change in food intake or eating behaviors between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in the change in feelings of stress or mood between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in the change in sleep between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? * Is there a difference in the change in mindfulness between the behavioral program that includes aerobic exercise plus yoga compared to the behavioral program that includes only aerobic exercise? Participants will: * Participate in a weight loss program for a period of 12 months that involves attending behavioral weight loss sessions. This involves coming to a session at the research center weekly for the initial 6 months and then every other week for the remaining 6 months. * Attempt to reduce the amount of food that they eat to reduce the calories they consume. * Participate in a combination of aerobic exercise plus yoga or just aerobic exercise. * Keep a record of the food they consume, use a digital scale provided to them, and wear an activity tracker provided to them for the period of 12 months. * Visit the clinical before starting the weight loss program, after 3 months, 6 months, 9 months, and 12 months to complete measurements of their weight and other measurements to monitor their progress. * Complete exercise sessions in the clinic between weeks 2-6, at month 6, and at month 12 to provide information about how they response to a single session of exercise. |
JOHN M. JAKICIC; | 2025-01-03 |
| 168 | A Multiple Dose, Randomized, Placebo-controlled, Dose-escalating Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered MD-18 for Healthy Subjects with Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: This study will be conducted as a single center study, at the Sheba Medical Center, Israel. Escalating daily doses of MD-18 or placebo will be administered subcutaneously to each … |
COHEN GLOBAL | 2025-01-02 |
| 169 | Efficacy and Safety of Tirzepatide for Weight Management in Overweight or Obese Adult Individuals With or Without Type 2 Diabetes Mellitus: A Real-World Study in Bangladesh PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn if tirzepatide helps people manage their weight safely. It will include adults in Bangladesh who are overweight or obese, with or without type 2 diabetes. The main questions it aims to answer are: Does tirzepatide help people lose weight? What side effects do people experience while taking tirzepatide? All participants will: Receive tirzepatide as a weekly injection, starting at 2.5 mg and gradually increasing to 15 mg. Continue the treatment for 52 weeks (12 months). Visit the clinic for regular checkups and tests. Researchers will measure changes in body weight, BMI, … |
FAHMIDA ISLAM CHOWDHURY; | 2025-01-01 |
| 170 | Workplace Weight Control Program: Combating Obesity in A Multinational Factory in Egypt PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of the work: to assess the impact of 3-months workplace weight control program on both work ability and the severity of Metabolic Syndrome. |
NOHA MOHAMMED ELGHAZALLY; | 2025-01-01 |
| 171 | Evaluation of The Risk of Developing Disordered Eating Behaviors or Eating Disorders in Children and Adolescents with Obesity Using A Digi-Physical Treatment Tool PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate the risk of developing disordered eating behavior or an eating disorder among children and adolescents with obesity who have used a digi-physical treatment tool with daily measurements conducted at home. The primary outcomes are to: * Evaluate the proportion of patients exhibiting documented signs of disordered eating behaviors during or after treatment (e.g., caloric restriction, skipping meals, binge eating). * Evaluate the proportion of patients diagnosed with an eating disorder (e.g., anorexia nervosa, bulimia nervosa, binge eating disorder) during or after treatment. Patients at Martina Childrens Hospital, Stockholm, Sweden, … |
PERNILLA DANIELSSON; | 2025-01-01 |
| 172 | Gastric Fundal Mucosal Ablation for Weight Management in Patients Stopping Glucagon-like Peptide-1 Receptor Agonists PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the effect of gastric fundal mucosal ablation (GFMA) on weight trajectory following discontinuation of once-weekly semaglutide or tirzepatide in adults with obesity. In this study, GFMA will be performed on patients who have experienced \> 10% weight loss with GLP-1 therapy and who plan to discontinue use of GLP-1 medications for the duration of the study. |
CHRISTOPHER MCGOWAN; | 2025-01-01 |
| 173 | Evaluation of Upper Extremity Functions in Patients with Obesity Hypoventilation Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity Hypoventilation Syndrome (OHS) is a disease characterized by daytime hypercapnia and sleep-related respiratory disturbances in individuals with a body mass index (BMI) greater than 30 kg/m², without any other condition that could lead to hypoventilation. Although various mechanisms play a role in the pathogenesis of OHS, the most significant one is the altered respiratory system mechanics due to obesity. Obesity also leads to a decrease in peripheral muscle strength and exercise capacity. It has been reported that in obese individuals, not only general body movements and lower extremities but also upper extremity movements are negatively affected. Specifically, … |
NILGÜN YILDIZ; | 2025-01-01 |
| 174 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study to Evaluate The Efficacy and Safety of VCT220 Tablets in Overweight or Obese Participants PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess how VCT220 tablets affect the bodyweight in obese or overweight adult participants. Participant will be randomly assigned to the high-dose group, low-dose group, or placebo group. Each participant will take the study drug orally once daily for 12 months. |
VINCENTAGE PHARMA | 2024-12-24 |
| 175 | An Open-label, Randomized, Parallel-group, Single-center Trial to Compare Pharmacokinetics of Dapiglutide After A Single Subcutaneous Dose of The Drug Product Concentrations 10 Mg/mL or 25 Mg/mL in Participants with Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 1, open-label, single-center, randomized, parallel-group trial designed to investigate the pharmacokinetic profiles, safety, and tolerability of a single dose administration of 7.5 mg dapiglutide administered s.c. with two drug product concentrations, 10 mg/mL and 25 mg/mL. The trial will be conducted in participants with a BMI ≥ 27.0 kg/m2. |
ULRIKE HOEVELMANN; | 2024-12-23 |
| 176 | A Phase 1/2a Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ARO-INHBE in Adult Volunteers With Obesity With and Without Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1/2a double-blind dose-escalating study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single and multiple doses of ARO-INHBE in adult participants with obesity (Part 1), and the safety, tolerability and PD of multiple doses of ARO-INHBE in adult participants with obesity with and without type 2 diabetes mellitus receiving tirzepatide (Part 2). |
ARROWHEAD PHARMACEUTICALS | 2024-12-21 |
| 177 | Community Engagement ALliance Against Disparities – Washington District of Columbia (DC), Maryland, and Virginia (CEAL-DMV) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The Community Engagement Alliance against Disparities – Washington District of Columbia, Maryland, Virginia (CEAL DMV), is a multi-community and multi-university consortium. Through collaboration and shared leadership, the CEAL-DMV the consortium- comprising five institutions: George Washington University, Howard University, Johns Hopkins University, Morgan State University, and the University of Maryland, Baltimore-has established a regional structure for bi-directional community involvement to engender trust and foster communication. Each site builds on thriving community partnerships, which have been instrumental in enhancing trust, community capacity, and readiness to reduce health disparities. |
CHERYL HIMMELFARB; | 2024-12-20 |
| 178 | A Phase 2, Randomized, Double-blind, Placebo-controlled, Study of The Safety, Tolerability, and Efficacy of Increasing Optimal Doses of GSBR-1290 in Participants Living With Obesity (Body Mass Index ≥ 30 Kg/m2) or Overweight (Body Mass Index ≥ 27 Kg/m2) With at Least One Weight-related Comorbidity (ACCESS II) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase 2 clinical study will evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of various GSBR-1290 dose regimens compared with placebo in participants living with obesity or overweight with ≥ 1 weight-related comorbidity, in addition to diet and exercise, over a 36-week period. |
GASHERBRUM BIO INC A WHOLLY OWNED SUBSIDIARY OF STRUCTURE THERAPEUTICS | 2024-12-20 |
| 179 | Response Of Metabolic Syndrome Severity Score To High Intenisty Interval Training In Women With Central Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to investigate any significant effect of high intensity interval training on metabolic syndrome severity score in women with central obesity. |
SOMA ADEL GABER ABD EL-GHANY; | 2024-12-20 |
| 180 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled, 13-week Dose Finding Study of VK2735 Oral Formulation for Weight Management in Subjects Who Are Obese, or Overweight With at Least One Weight-related Comorbid Condition PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2, 13-week randomized, double-blind, placebo-controlled, parallel arm dose-finding study that will evaluate the safety, tolerability, weight loss efficacy, pharmacodynamic effects, and pharmacokinetics of VK2735 Oral Formulation in adults who are obese (BMI ≥30 kg/m2) or who are overweight (BMI ≥27 kg/m2) with at least one weight-related co-morbid condition. VK2735 or matched placebo will be administered once daily. |
VIKING THERAPEUTICS | 2024-12-18 |
| 181 | Effects of A Culturally Significant Cardiovascular Dance-based Intervention in Obese Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to analyze a culturally relevant cardiovascular dance-based intervention called Fitfolk in overweight or obese Mapuche women from a rural community in Padre las Casas. Participants will be randomly assigned to two groups: an experimental group that will receive a culturally relevant cardiovascular dance program (EG, n=11), and a control group that will receive a conventional physical exercise program (CG, n=11). Both groups will be trained at a community center in the same rural area, led by a physical education professional. The principle of training progression will be followed, … |
UNIVERSIDAD CATOLICA SILVA HENRIQUEZ | 2024-12-16 |
| 182 | Metabolic Dysregulation As The Underlying Principle of Integrated Pathophysiology of Obesity-associated Chronic Diseases: Molecular Landscape of Complex Lifestyle Modification PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to detect the impact of the 3-month complex lifestyle intervention, consisting of dietary counselling, supervised exercise training and cognitive-behavioural intervention in middle-aged sedentary individuals with obesity, specific questions are: * What is the adaptive response to exercise training on the whole-body and skeletal muscle energy metabolism, insulin sensitivity, metabolic flexibility, … |
JOZEF UKROPEC; | 2024-12-15 |
| 183 | The Role of Microbiome in Recurrent Obesity Before and After Antibiotic/Placebo Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This past century witnessed a significant increase in the prevalence of obesity. Successful weight loss maintenance is defined as losing at least 10% of the initial body weight and maintaining it for at least one year. However, keeping a low body weight is rarely maintained, as 80% of people who lost 10% of their body weight will return to their initial weight within a year. Although there is no agreement as to what contributes to the recurrent weight regain phenomenon (also known as ‘weight cycling’ or ‘yo-yo diet’), … |
HILA ELINAV; | 2024-12-11 |
| 184 | A Randomized, Double-blind, Phase 2, Dose-finding Trial of Once Weekly Petrelintide Compared With Placebo in Participants With Obesity or Overweight With Weight Related Comorbidities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to compare dose levels of petrelintide versus placebo with regards to effect on body weight, safety, and tolerability. |
ZEALAND PHARMA | 2024-12-09 |
| 185 | Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity in The Real World PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective database study which includes administrative medical and pharmacy claims linked with clinical and laboratory measurements for patients in the US, to evaluate the effectiveness of once-weekly semaglutide 2.4 mg in reducing the risk of CV and other obesity-related clinical outcomes. |
NOVO NORDISK | 2024-12-06 |
| 186 | A Phase 1B, Randomized, Open-label, Active-controlled, Parallel, Multiple-dose Study Comparing The Safety, Pharmacokinetics and Efficacy of Dehydratech Cannabidiol and Glucagon-like Peptide 1 Agonists Alone and in Combination, in Overweight or Obese, Pre-and Type 2 Diabetic Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1b, randomized, open-label, active-controlled, parallel, multiple-dose study comparing the safety, pharmacokinetics and efficacy of DehydraTECH Cannabidiol and Glucagon-like Peptide 1 (GLP-1) agonists alone and in combination, in overweight or obese, pre- and type 2 diabetic participants. |
LEXARIA BIOSCIENCE | 2024-12-04 |
| 187 | Early Brain Development and Child Nutrition and Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity. |
SUSAN CARNELL; | 2024-12-02 |
| 188 | Efficacy, Safety and Pharmacokinetics of NNC0519-0130 Once Weekly S.c. Versussemaglutide 1.0 Mg and Placebo in People With Chronic Kidney Disease, With or Without Type 2 Diabetes, and With Overweight or Obesity: A Proof-of-concept and Dose-finding Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study evaluates the safety of different doses of a new medicine called NNC0519 0130. It also looks into how the medicine may improve kidney function in participants with chronic kidney disease with or without type 2 diabetes, living with overweight or obesity. The participants will either get NNC0519-0130 (a new medicine), semaglutide (a medicine that doctors can already prescribe), or placebo (a dummy substance). Which treatment the participant will get is decided by chance. The study will last for up to 43 weeks. |
NOVO NORDISK | 2024-12-02 |
| 189 | Comparing The Pharmacokinetics of Cagrilintide and Semaglutide Following Single Subcutaneous Doses of Different CagriSema Presentations, in A Crossover Manner in Adult Participants With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will compare the blood levels of cagrilintide and semaglutide when the same dose is given in two different versions of CagriSema. CagriSema is a medicine that combines two medicines called cagrilintide and semaglutide. It is still being tested in studies and is not yet available for doctors to prescribe. Participants will get an injection with each of the two versions of CagriSema at two different times at the clinic. Like all medicines, the study medicine may have side effects. The study will last for about 18 weeks. |
NOVO NORDISK | 2024-12-02 |
| 190 | Clinical Study Evaluating The Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy (LSG) for Morbid Obese Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Assessment of the effect of gabapentin as an analgesic replacement on the Kidney function following Laparoscopic sleeve gastrectomy for Morbid Obese Patients by measuring two biomarkers: NGAL (Neutrophil gelatinase-associated lipocalin)and DKK3 (Dickkopf-3) |
KHOLOUD SALAH IBRAHIM AMIN; | 2024-12-01 |
| 191 | An Observational, Multicenter, National Study with Real-life Retrospective Data Collection on The Combined Use of Sibutramine and Topiramate As Anti-obesity Treatment in Overweight Patients with Comorbidity(ies) or Obesity Related Papers Related Patents Related Grants Related Experts View Highlight: An observational, multicenter, national study with retrospective real-life data collection on the combined treatment of sibutramine and topiramate (off-label use) for the treatment of overweight with comorbidity(ies) or obesity. Data from all adult patients, of both sexes, for whom combination treatment with sibutramine and topiramate, both at any dose/dosage, were prescribed between the year 2011 and the beginning of the study will be included in the study. |
EUROFARMA LABORATORIOS S A | 2024-12-01 |
| 192 | Experimental Approach to Test Predictions of Body Weight Regulation Models PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The regulation of human body weight and fatness is not fully understood. Although some models of regulation have been proposed (set point, dual-intervention point, others), no studies have been designed to test their predictions. In this pilot and feasibility study, the investigators will implement an experimental approach to test the predictions of models of body weight regulation in humans. Men and women with either low body weight or obesity will be exposed to a 2-day fasting followed by a 2-day ad-libitum refeeding. During the entire fasting-refeeding period, … |
RODRIGO FERNANDEZ-VERDEJO; | 2024-11-26 |
| 193 | Beta-Cell – Liver Interactions in Situations of Modified Beta-Cell Function: From Mice to Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will measure blood levels of 1,5-anhydroglucitol in obese children with or without type 2 diabetes and correlate them with parameters related to functional beta-cell mass and glucose metabolism. The values will be compared to those obtained in healthy volunteers. The aim of the study is to test the validity of 1,5-anhydroglucitol as a novel biomarker of beta-cell mass and function in children with obesity with or without type 2 diabetes. |
PHILIPPE KLEE; | 2024-11-22 |
| 194 | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Phase 2 Study to Evaluate The Efficacy, Safety, and Tolerability of Once-Weekly CT-388 Administered Subcutaneously for 48 Weeks to Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of CT-388 at low, middle, and high doses in participants who are overweight or obese with Type 2 diabetes mellitus (T2DM). |
CARMOT THERAPEUTICS | 2024-11-21 |
| 195 | Effect of Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA): A Randomized, Double-Blind, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a trial of tirzepatide in people with obesity and knee osteoarthritis. The main purpose of this study is to see if tirzepatide can reduce number of these participants who require a knee replacement. Participants will be randomized to take a weekly injection of tirzepatide or a placebo for a total of 72 weeks. |
MICHELLE M DOWSEY; | 2024-11-19 |
| 196 | A Master Protocol for A Randomized, Controlled, Clinical Platform Trial to Investigate The Efficacy and Safety of Interventions for Chronic Weight Management in Pediatric Participants With Obesity or Overweight PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pediatric, chronic weight management, Phase 3 Master Protocol (PWMP) is to create a framework to evaluate the safety and efficacy of pharmacologic agents for the treatment of obesity or overweight in pediatric participants. |
CAREY CHRONIS; | 2024-11-18 |
| 197 | Efficacy, Safety, and Pharmacokinetics of Orforglipron Once Daily Oral Versus Placebo in Adolescent Participants Who Have Obesity, or Overweight With Weight-Related Comorbidities: A Randomized, Double-Blind Trial (ADVANCE-ATTAIN-ADOLESCENTS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study, performed under Master Protocol J4M-MC-PWMP, is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with obesity, or overweight with related comorbidities. Participation in the study will last about 18 months. |
CAREY CHRONIS; | 2024-11-18 |
| 198 | A Phase 2, Parallel-Group, Double-Blind Study to Investigate Weight Management With LY3549492 Once Daily Compared With Placebo in Adult Participants With Obesity or Overweight PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to evaluate the effects of LY3549492 in adults with obesity or overweight. Participation in the study will last about one year. |
ELI LILLY | 2024-11-13 |
| 199 | Multinational Cross-sectional Review of Diabetes and Obesity Management in Hospitals Across Europe: The DIABESITY Survey PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes related to obesity (diabesity) is becoming increasingly prevalent. Hospitalizations among people with diabetes are frequent and glycaemic control is often suboptimal during these stays. However, the pharmacological treatment of diabesity has made significant progress in recent years. The objective of this study is to assess the management of diabesity in the international hospital setting. Aims include: 1. to determine the prevalence of causes and duration of hospitalization 2. to investigate the treatments used 3. to determine individual metabolic control achived This is a cross-sectional multi-centre study in which researchers will conduct a one-day point prevalence assessment in internal medicine wards. |
ANN-KRISTIN PORTH; | 2024-11-13 |
| 200 | A Randomized, Double-blind, Placebo-controlled Phase Ⅲ Clinical Study to Evaluate The Efficacy and Safety of HS-20094 in Overweight and Obese Subjects PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the Efficacy and safety of HS-20094 in overweight and obese patients. The study will last up to approximately 52 weeks. |
JIANGSU HANSOH PHARMACEUTICAL | 2024-11-11 |
| 201 | A Study to Evaluate The Efficacy, Safety & Tolerability of Maridebart Cafraglutide in Adults With T2DM PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the dose-response relationship of maridebart cafraglutide on glucose control compared with placebo. |
AMGEN | 2024-11-07 |
| 202 | The Effect of Mediterranean Diet and Mindfulness Eating on Depression Severity in People With Obesity and Major Depressive Disorder – A Randomized Controlled Study With Mulitfactorial Design PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study investigates the effect of Mediterranean Diet and Mindful Eating on depression severity in people with obesity and major depressive disorder. The factorial design allows to investigate potential synergistic effects of the interventions. Participants will be randomized to one of the four intervention groups (mediterranean diet, mindful eating, their combination and a befriending control group). The intervention consists of a 12-week period, followed by a 12-week follow up. The primary outcome is depression severity. |
UNIVERSITY HOSPITAL TUEBINGEN | 2024-11-05 |
| 203 | Ultrasound Lipolysis Versus Cryolipolysis On Lipid Profile Levels In Centrally Obese Middle Aged Men PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study compares the effects of ultrasound lipolysis and cryo lipolysis on cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, body mass index, skin thickness, waist circumference, and waist hip ratio in centrally obese middle aged men. It also investigates the impact of ultrasound lipolysis on skin thickness, waist circumference, and waist hip ratio. |
MUSTAFA AWAD ALI AWAD; | 2024-11-05 |
| 204 | Psychoneuroimmunology As A Framework for Studying The Effects of Chiropractic Care in A Population with High Central Adiposity: A Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Since 1980, the global prevalence of obesity, commonly defined as a body mass index (BMI) of 30 or higher, has doubled. Importantly, high levels of central adiposity (i.e., abdominal fat) is associated with numerous PNI-related sequelae, including increased levels of psychological distress, cognitive deficits, ANS dysfunction, and immune marker abnormalities. To our knowledge, rigorous investigation of chiropractic’s impact on psychoneuroimmunological (PNI)-related outcomes in people with high central adiposity is lacking. Based on limited evidence to date, it is plausible that clinically important PNI-related dysfunctions (e.g., heightened stress levels, executive function impairments, dysautonomia, … |
TYSON PEREZ; | 2024-11-04 |
| 205 | A Phase 3, Randomized, Double-Blind Study to Evaluate The Efficacy and Safety of Retatrutide Compared to Tirzepatide in Adults Who Have Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the efficacy and safety of retatrutide compared to tirzepatide in adults who have obesity. The study will last about 89 weeks. |
ELI LILLY | 2024-11-01 |
| 206 | The Physiological Responses of Muscle Strengthening Training with Pilates Reformer in Overweight-obese Women and Women with Normal Body Weight PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the physiological responses and the metabolic burden of a Pilates Reformer strength training session in physically inactive premenopausal women with a body mass index of 18-24.9 and 25.01-39.9. The sample included 20 women divided into two groups: 10 with normal weight (NW) and 10 with overweight/obesity (OB). In a non-randomised control design, the participants will perform a 60-minute muscle-strengthening session with Pilates Reformer equipment. |
SYROU NIKI; | 2024-11-01 |
| 207 | CRAVE Study: Comparing Craving Responses and Diet Quality of GLP1 Receptor Agonist Users Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the impact of GLP-1 receptor agonists, semaglutide and tirzepatide, on food cravings and diet quality in individuals with overweight or obesity. Over 24 weeks, up to 150 adult participants will be monitored using questionnaires and dietary records at 0, 12, and 24 weeks to measure changes in diet quality, disordered eating, food cravings, and hunger. This research, conducted with Seen Medical Group at Knownwell Health Clinic, seeks to fill the gap in literature on the dietary quality effects of GLP-1RAs. |
UNIVERSITY OF CALIFORNIA DAVIS | 2024-11-01 |
| 208 | To Explore The Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Multiple Doses of HRS-7535 in Obese Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being conducted to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple doses of HRS-7535 tablet in obese subjects. |
SHANDONG SUNCADIA MEDICINE | 2024-10-30 |
| 209 | GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot clinical trial is to determine the effectiveness of Tirzepatide in patients with persistent obesity (BMI \> 30) 12 months after bariatric surgery (Roux-en-Y Gastric Bypass). The investigators also aim to determine the frequency of side effects with Tirzepatide in this patient population. Patients who take tirzepatide 12 months after bariatric surgery will be compared to patients who continue with the current standard of care for patients who have previously undergone Gastric Bypass Surgery. |
JASON SAMUELS; | 2024-10-30 |
| 210 | A Phase I, Open-label, Fixed-sequence Study to Evaluate The Effect of Repeated Subcutaneous Injections of GZR18 Injection on The Pharmacokinetics of Oral Metformin Hydrochloride Tablets in Overweight/Obese Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, open-label, fixed-sequence phase I clinical study to evaluate the effect of multiple subcutaneous injections of GZR18 Injection on the pharmacokinetics of multiple oral doses of metformin hydrochloride tablets. |
GAN AND LEE PHARMACEUTICALS USA | 2024-10-30 |
| 211 | Acute Effects of Ultra-processed Versus Unprocessed Foods on Glucocorticoid Secretion in Healthy Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators aim to understand whether the acute cortisol response to food differs between differently processed foods. In this monocentric, randomized, cross-over, open-label study, 20 healthy volunteers will receive two differently processed meals of similar caloric content and composition. The study will primarily focus on changes in blood cortisol levels, but other metabolic parameters will also be compared. |
ELEONORA SEELIG; | 2024-10-30 |
| 212 | Investigating The Effect of The Combination of L-carnitine Tartrate, Dihydrocapsiate and Protein Yeast Hydrolysate (DNF10) for 12 Weeks on Energy Intake and Energy Expenditure in Overweight and Obese Adults: A Randomised Controlled Trial- (SPICE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-centre, double-blind, randomised, placebo-controlled, 2-arm, parallel-design trial. This trial will examine the impact of a combined treatment of L-carnitine tartrate, dihydrocapsiate and protein yeast hydrolysate (otherwise known as the study product) over 12 weeks on energy intake and expenditure in overweight and obese adults. Approximately 44 participants will be recruited to this trial. Participants will give consent to investigator sites to collect their data. The participants will either be randomised to take the study product or placebo. The main question that this trial aims to answer is: The effect of the study product (L-carnitine tartrate, … |
EDWARD CHAMBERS; | 2024-10-30 |
| 213 | A Phase 2b, Multi-Center, Randomized, Placebo-Controlled Double-Blind Study to Investigate The Safety and Efficacy of Once-Weekly MET097 in Participants with Obesity and Overweight (VESPER-1) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to test how well MET097, an active drug, works to treat individuals with obesity or overweight when compared to placebo. MET097 or placebo will be given to individuals weekly for 28 weeks. If an individual is assigned to MET097 they will receive one of four different dose levels. |
METSERA | 2024-10-24 |
| 214 | A Master Protocol to Investigate The Efficacy and Safety of Orforglipron Once Daily in Participants Who Have Obstructive Sleep Apnea and Obesity or Overweight: A Randomized, Double-Blind, Placebo-Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Study GZRA is a master protocol that will support 2 independent studies, GZ01 and GZ02. Participants will be assigned to the appropriate study prior to randomization. The purpose of the studies is to evaluate the efficacy and safety of orforglipron in participants who have moderate-to-severe OSA and obesity or overweight. Study GZ01 will include participants who are unable or are unwilling to use PAP therapy. Study GZ02 will include participants who are on PAP therapy for at least 3 months at time of screening and plan to continue PAP therapy during the study. |
APINYA VUTIKULLIRD; | 2024-10-22 |
| 215 | A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study of Bimagrumab and Tirzepatide, Alone or in Combination, to Investigate The Efficacy and Safety in Adult Participants With Obesity or Overweight Without Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the efficacy and safety of Bimagrumab and Tirzepatide, alone or in combination, in adults with obesity or overweight, with at least one obesity related comorbidity, without Type 2 Diabetes. The study will last about 70 weeks. |
ALMENA FREE; | 2024-10-21 |
| 216 | A Phase 1, Double-Blind, Parallel-arm, Placebo-Controlled, Multiple-dose Study to Evaluate The Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BGM0504 Injection Administered Subcutaneously in Non-diabetic Overweight or Obese Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1, double-blind, parallel-arm ,placebo-controlled study. The study will evaluate the pharmacokinetics (PK), pharmacodynamic (PD), safety and tolerability of BGM0504 following multiple subcutaneous (SC) administrations in non-diabetic overweight or obese adult subjects. |
BRIGHTGENE BIO MEDICAL TECHNOLOGY | 2024-10-21 |
| 217 | Effect of Akkermansia Muciniphila Akk11 on Metabolic and Gut Health in Overweight and Obese Subjects: A Randomized, Double-blind, Placebo-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the efficacy and safety of the use of probiotics as a food supplement compared to placebo in regulating body metabolism and gut microbiota in overweight or obese subjects. |
WECARE PROBIOTICS | 2024-10-20 |
| 218 | Effects of High Intensity Interval Training Vs. Moderate Intensity Continuous Training on Fat Loss,Serum Adiponectin,Leptin,Omentin Level,Sleep and Quality of Life in Young Females With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is one of the most common preventable public health problems. Diet regulation and exercise practices are the most commonly used methods in reducing fat tissue. There are various exercise methods applied in the weight loss process and the effects of different types of exercise modalities on body fat rate and metabolic status.The aim of our study is to determine the effects of high intensity interval exercise and moderate intensity continuous exercise on serum , omentin, leptin and adiponectin levels, anthropometric measurements used in obesity follow up, … |
FIGEN TUNCAY; | 2024-10-18 |
| 219 | A Phase 2b, Randomized, Double-blind, Placebo-controlled, Dose-range Finding Study of The Efficacy and Safety of Multiple Doses of GSBR-1290 in Participants Living With Obesity (Body Mass Index ≥ 30 Kg/m2) or Overweight (Body Mass Index ≥ 27 Kg/m2) With at Least One Weight-related Comorbidity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, double-blind, placebo-controlled, dose-range finding study of the efficacy, safety, tolerability, PK, and PD of multiple doses of GSBR-1290 in participants living with overweight or obesity with at least one weight-related comorbidity. Participants will be randomized to GSBR-1290 or placebo in a ratio of 3:1 within each Cohort receiving multiple-ascending, QD doses of GSBR-1290 or placebo in titration steps of 4 weeks duration for a total of 36 weeks of treatment. |
GASHERBRUM BIO INC A WHOLLY OWNED SUBSIDIARY OF STRUCTURE THERAPEUTICS | 2024-10-17 |
| 220 | Investigation of Pharmacokinetics of 2 Different Formulations of NNC0519-0130 in Adult Participants With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look into a new study medicine called NNC0519-0130 to improve the treatment option for people living with excess body weight or type 2 diabetes or both. The purpose of this study is to compare the amount of NNC0519-0130 in the blood of participants who have excess body weight. The study comprises two parts and the participants will receive both preparations NNC0519-0130 B and NNC0519-0130 C, which treatment the participants get is decided by chance. The study will last for about 24 weeks. |
NOVO NORDISK | 2024-10-15 |
| 221 | Effects of Synbiotics on Obesity and Obesity-related Parameters PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Synbiotics are a combination of probiotics and prebiotics that can promote the survival of probiotics in the gut. Probiotics utilize prebiotics to produce various metabolites beneficial to human health, such as short-chain fatty acids. The purpose of this trial is to evaluate the impact of a synbiotics product developed by Leewenhoek Laboratories Co., Ltd., on human obesity and its related biomarkers. Participants will be randomly assigned to either the experimental group or the control group in a double-blind trial. The intervention involves the experimental group taking the synbiotics product twice daily, two capsules per dose, … |
LEEUWENHOEK LABORATORIES | 2024-10-15 |
| 222 | Creation of Side-to-Side Compression Anastomosis Using The GT Metabolic Solutions Magnet System, DI Biofragmentable (MagDI System) in Chile to Achieve Duodeno-Ileostomy Diversion in Adults With Obesity and With or Without Type 2 Diabetes Mellitus (MagDI Chile Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the MagDI Chile Study is to evaluate the feasibility / performance, safety, and initial efficacy of the MagDI System in eligible participants who are indicated for a duodeno-ileal (small bowel) side-to-side anastomosis procedure for partial intestinal diversion (e.g., one example of a small bowel clinical procedure requiring a side-to-side anastomosis). |
GT METABOLIC SOLUTIONS | 2024-10-14 |
| 223 | Randomized Controlled Pilot Clinical Study Including Kombucha in The Diet of Individuals with Overweight and Class 1 Obesity: Comparative Assessment Between Live and Pasteurized Kombucha and Its Effects on Gut Microbiota, Metabolic Parameters, and Liver Function [FUSILLI Project -H2020] PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Kombucha, a fermented beverage made from Camellia sinensis tea (black, oolong, or green) with sugar and a symbiotic culture of bacteria and yeast (SCOBY), has gained global attention for its potential health benefits. Factors like the type and amount of sugar substrate, fermentation time, and temperature significantly influence its organic compounds, total phenolics, vitamin content, and alcohol levels. In a previous study, kombucha’s impact on glucose tolerance, insulin sensitivity, body composition, … |
INÊS BRANDÃO; | 2024-10-11 |
| 224 | A Phase IIb Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety and Tolerability of AZD5004 in Participants Living With Obesity or Overweight With Comorbidity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase IIb, global, randomized, parallel-group, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of AZD5004 compared with placebo, given once daily as an oral tablet(s) for 36 weeks, in male and female participants at least 18 years of age who are living with obesity (body mass index \[BMI\] ≥ 30 kg/m2), or overweight (BMI ≥ 27 kg/m2) who have at least 1 weight-related comorbidity |
MELANIE DAVIES; | 2024-10-08 |
| 225 | Sustainable Eating for A Healthy Tomorrow – Effectiveness of Digital Nutrition Workshops to Implement The Planetary Health Diet for Hospital Employees PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will explore the effect of digital media on communicating a planetary diet and invite participants to change dietary habits. Standardized questionnaires, physical examinations, and qualitative interviews will be used to obtain data on the effectiveness of the intervention. Once initial assessments are complete, a blinded researcher will randomly assign participants to one of two groups, without influence from either participants or study coordinators. Both groups will participate in a nutrition course over a 13-week period, followed by a booster session five months after randomization, … |
HEIDEMARIE HALLER; | 2024-10-07 |
| 226 | An Open-label, Non-randomised, Fixed-sequence, Two Period, Phase I Trial to Evaluate The Effect of Different Doses of BI 456906 (Survodutide) on The Single Dose Pharmacokinetics of Bupropion, Caffeine and Midazolam on Otherwise Healthy Volunteers With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults with overweight or obesity who are otherwise healthy. People can join the study if they have a body mass index of 27 to 39.9 kg/m2 and a body weight over 70 kg. The purpose of this study is to find out whether taking multiple doses of BI 456906 influences the amount of bupropion, caffeine, and midazolam in the blood. The study has 2 treatment periods. In Period 1, participants take 1 dose each of midazolam, caffeine, and bupropion as tablets or oral solution on separate days. In Period 2, … |
BOEHRINGER INGELHEIM | 2024-10-03 |
| 227 | A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Obesity or Overweight With Comorbidity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of AZD6234 compared with placebo, given once a week as subcutaneous injection for 36 weeks, in male and female participants of at least 18 years of age who are living with obesity (body mass index \[BMI\] ≥ 30 kg/m2), or overweight (BMI ≥ 27 kg/m2) and at least one weight-related comorbidity |
ASTRAZENECA | 2024-10-01 |
| 228 | Effect of Brain Gym Exercises on Risk of Fall, Balance and Quality of Life in Obese Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be done to answer the following question: Do brain gym exercises have an effect on risk of fall, static balance, dynamic balance and risk of fall and quality of life in obese subjects? |
AYA ABDELHADY AHMED ALI ELERIAN; | 2024-10-01 |
| 229 | A Phase I, Open-Label, Single-Arm, Fixed-Sequence Study to Evaluate The Effect of Repeated Administration of HDM1002 on The Pharmacokinetics of Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy and Overweight Adult Chinese Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to characterize the effect of HDM1002 on the PK of single dose of repaglinide, atorvastatin, digoxin and rosuvastatin in healthy adult subjects. The safety and tolerability of HDM1002 with repaglinide, atorvastatin, digoxin and rosuvastatin when given separately or together will also be evaluated. |
CUI CHENG; | 2024-10-01 |
| 230 | A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study Evaluating The Efficacy, Safety, and Pharmacokinetics of Daily Administrations of The GLP-1 Analogue ROSE-010 on Appetite and Food Intake in Overweight and Obese Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to assess the efficacy of ROSE-010 on food intake in female subjects with overweight and obesity. The secondary objectives of this study are the following: – To assess the efficacy of ROSE-010 on hunger; – To assess the efficacy of ROSE-010 on satiety; – To assess the efficacy of ROSE-010 on prospective consumption; – To assess the efficacy of ROSE-010 on desire to eat; – To assess the efficacy of ROSE-010 on palatability; – To characterize the pharmacokinetics (PK) of ROSE-010 following subcutaneous (SC) administration on Day 1 and Day 7; and – … |
ROSE PHARMA | 2024-10-01 |
| 231 | Efficacy and Safety of Ixekizumab or Ixekizumab Concomitantly Administered With Tirzepatide in Adult Participants With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight: A Phase 3b, Randomized, Multicenter, Open-Label Study (TOGETHER-PsO) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to demonstrate that when participants with moderate to severe plaque psoriasis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in their psoriasis and achieve weight reduction compared to when receiving ixekizumab. Participation in this study includes up to 12 visits and could last up to 61 weeks including screening, open label treatment period, and post-treatment follow-up period. |
JAMES KRELL; | 2024-09-30 |
| 232 | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of RDX-002 on Postprandial Triglycerides in Patients Discontinuing The Glucagon-like Peptide-1 (GLP-1) Agonists, Semaglutide or Tirzepatide, for The Treatment of Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if drug RDX-002 works to treat high levels of fat (known as triglycerides, or TGs) in the blood in adults. It will also learn about the safety of drug RDX-002. The main question it aims to answer is if treatment with RDX-002 will lower triglycerides after a high-fat meal in patients who have recently stopped treatment with semaglutide or tirzepatide for obesity. The trial will also examine the effect of RDX-002 on body weight and fasting levels of cholesterol. Researchers will compare RDX-002 to a placebo (a look-alike substance that contains no drug) to see if RDX-002 works to reduce triglycerides. Participants will: Take drug RDX-002 or a placebo every day for 12 weeks Visit the clinic once every 4 weeks for checkups and tests |
TRISHA STAMP; | 2024-09-27 |
| 233 | Efficacy and Safety of Ixekizumab or Ixekizumab Concomitantly Administered With Tirzepatide in Adult Participants With Active Psoriatic Arthritis and Obesity or Overweight: A Phase 3b, Randomized, Multicenter, Open-Label Study (TOGETHER-PsA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to demonstrate that when participants with psoriatic arthritis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in their psoriatic arthritis and achieve weight reduction compared to when receiving ixekizumab. Participation in this study includes up to 12 visits and could last up to 61 weeks including screening, open label treatment period, and post-treatment follow-up period. |
ELI LILLY | 2024-09-24 |
| 234 | A Phase 2, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With LY3841136 and Tirzepatide, Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate the safety and efficacy of LY3841136 for chronic weight management alone or in combination with Tirzepatide across a wide dose range in participants with Type 2 Diabetes. Participation in the study will last about 64 weeks. |
YESSICA SACHDEVA; | 2024-09-20 |
| 235 | Creation of Side-to-Side Compression Anastomosis Using The GT Metabolic Solutions Magnet System, DI Biofragmentable (MagDI System) in Italy to Achieve Duodeno-Ileal Diversion in Adults With Obesity and With or Without Type 2 Diabetes Mellitus (MagDI Italy Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the MagDI Italy Study is to evaluate the feasibility / performance, safety, and initial efficacy of the MagDI System in eligible participants who are indicated for a duodeno-ileal (small bowel) side-to-side anastomosis procedure for partial intestinal diversion (e.g., one example of a small bowel clinical procedure requiring a side-to-side anastomosis). |
GT METABOLIC SOLUTIONS | 2024-09-20 |
| 236 | Weight Maintenance in Adolescents With Obesity; Long-Term Treatment With Semaglutide S.c.2.4 Mg Once-weekly PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is testing how well semaglutide can help adolescents with excess body weight to lose weight and to maintain weight loss. All participants in the study will receive semaglutide as a weekly injection. The study medicine is injected with a thin needle in the stomach, thighs or upper arms. All participants will get semaglutide treatment for a minimum of 3 years. |
NOVO NORDISK | 2024-09-17 |
| 237 | A Phase I, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study to Evaluate The Safety, Tolerability, and Pharmacokinetics of ASC30 Injection, for Subcutaneous Use in Participants With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 1 randomized, double-blind, placebo-controlled single ascending dose (SAD) study designed to evaluate the safety and tolerability of ASC 30 injection, for subcutaneous use in participants with obesity. |
ASCLETIS PHARMA CHINA CO | 2024-09-16 |
| 238 | A Randomized, Single-centre, Double-blind, Placebo-controlled Proof-of-concept Parallel Group Clinical Trial to Investigate The Efficacy, Safety and Tolerability of Weekly Subcutaneous Dosing of CK-0045 in Participants with Overweight/obesity and Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if treatment with CK-0045 improves blood sugar control after a meal in participants with type 2 diabetes mellitus (T2DM) and overweight/obesity. It also aims to learn if CK-0045 can reduce body weight in these patients. The main question it aims to answer is: • Does 16 weeks of treatment with CK-0045 improve blood sugar control after a meal in participants with overweight or obesity and T2DM? Researchers will compare two dose levels of CK-0045 to a placebo arm (a look-alike substance that contains no drug) to see if CK-0045 improves blood sugar control. Participants will: * Have CK-0045 or placebo injected subcutaneously (under the skin) once weekly over a period of 16 weeks. * Visit the clinic 24 times and stay overnight at 2 of the visits. * During the visits blood samples will be collected and several other assessments/examinations will be performed to learn about the effects (and potential side effects) of CK-0045. |
MARC STOFFEL; | 2024-09-16 |
| 239 | Pilot Study on The Analysis of The Metabolic Phenotype in Individuals With Difficulties in Losing and Gaining Weight PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines why some individuals with obesity have difficulty losing weight, whereas some lean individuals struggle to gain weight. The investigators will measure how the human body uses energy during a fasting period and after consumption of a specially designed, low-protein meal. By comparing these responses, the investigators aim to identify different metabolic phenotypes that affect weight control. Findings from this research may lead to more personalized treatments for managing weight. Participation in this study involves simple tests and basic body measurements. |
TIM HOLLSTEIN; | 2024-09-16 |
| 240 | Effects of Intrinsic Foot Muscle With and Without Hip Abductor Muscle Strengthening Training in Overweight Females With Pronation Distortion Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: pronation distortion syndrome is a common postural distortion of the lower extremity, involving the anterior part of the leg. It may cause pain in the leg and disturbances in the tarsal part, in addition to distal and proximal parts. In this deformity, the head of the talus and navicular bones are rotated inward and downward, and the body’s center of gravity shifts inward, … |
RABIYA NOOR; | 2024-09-15 |
| 241 | A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of Orforglipron Once Daily Versus Placebo for Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the efficacy and safety of orforglipron on maintenance of body weight reduction. |
ELI LILLY | 2024-09-13 |
| 242 | A Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose and Multiple Ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 513 in Participants With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses. |
AMGEN | 2024-09-09 |
| 243 | In-depth Survey for The Reasons of Weight Control Difficulties PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to investigate the causes of weight control difficulties in overweight or obese patients .Overweight or obese Chinese patients were enrolled. According to their age, 3 males and 3 females (24 in total) aged 14-20 years, 21-40 years, 41-60 years and 61-80 years were included for interview for about 1 hour. The interview included demographic basic information and other characteristics, time and results of weight control, and causes of weight control difficulties. After collecting the information, classification and summary analysis were performed. |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2024-09-07 |
| 244 | A Multiple-Ascending Dose Study to Investigate The Safety, Pharmacokinetics, and Pharmacodynamics of LY3537031 in Overweight and Obese Participants and Healthy Volunteers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 3-part study that includes a Part A, Part B, and Part C. Part A will study the safety and tolerability of the study drug known as LY3537031 in participants who are overweight and obese. Part B and Part C will study the safety and tolerability of LY3537031 in healthy participants. Part C will contain only Japanese and Chinese healthy participants. Blood tests will be performed to check how much LY3537031 gets into the bloodstream and how long it takes the body to eliminate it. Body weight will be measured. The study will last approximately 20 weeks excluding a screening period. |
STEVEN REYNOLDS; | 2024-09-05 |
| 245 | Functional Cereal Products and Contribution to The Regulation of Metabolism and Obesity-induced Chronic Low-grade Inflammation-MetaflammationBread PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to find out the possible beneficial effects of a white wheat bread enriched with oat beta-glucans on mildly hypercholesterolemic subjects with overweight/obesity. The main questions it aims to answer are: Does the enriched bread lower total and LDL-cholesterol levels as well as the levels of inflammatory factors of the participants? Does the enriched bread positively change the composition of gut microbiota? Researchers will compare the enriched bread to a common white wheat bread to see if the enriched bread provides additional effect beyond a hypocaloric dietary plan that the participants of both groups are going to follow. Participants will: Take the enriched or the common bread every day for 8 weeks. Visit the clinic once every 2 weeks for checkups and tests. |
AMALIA YANNI; | 2024-09-02 |
| 246 | Peau O Le Vasa: Accelerating The Currents of Health Equity for Pasifika People PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Native Hawaiians and Pacific Islanders (NHPIs) are defined as the descendants of the original peoples of Polynesia (e.g., Hawai’i, Sāmoa, and Tonga), Melanesia (e.g., Fiji), and Micronesia (e.g., Guam, Chuuk, and Marshall Islands). Their history with the U.S. parallels that of American Indians and Alaska Natives. Before Western contact, NHPIs had thriving societies with rich cultural traditions. After contact, NHPI communities were decimated to near extinction by infectious diseases, exploited for their cultural and natural resources, displaced from their ancestral lands, forced to assimilate to Western ways, and marginalized through legislative acts and compulsory assimilation policies (i.e., … |
JOSEPH K KAHOLOKULA; | 2024-09-01 |
| 247 | A Randomized Study to Investigate The Effect of Low-calorie Diets With Different Macronutrient Composition and Macronutrient Distribution in Shift Workers With Prediabetes or Type 2 Diabetes and Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Aims: Shift work, particularly involving night shifts, is associated with increased risk of metabolic disturbances such as type 2 diabetes mellitus (T2DM). Thus, it is important to explore mechanisms underlying this deleteroius effect and strategies that could prevent or mitigate it. The aim of the study is to investigate the effect of three low-calorie diets with different macronutrients composition and distribution along day on glucose metabolism and other health outcomes in overweight or obese shift workers with prediabetes or T2DM. Methods: In this randomized controlled trial, … |
ROCIO MATEO-GALLEGO; | 2024-09-01 |
| 248 | Metabolic Features Effect on FibroScan-AST (FAST) Score in Egyptian Patients with Metabolic-Associated Steatotic Liver Disease (MASLD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational cross-sectional study is to evaluate the effect of metabolic features on Fibroscan-AST (FAST) score stratification in metabolic dysfunction-associated steatotic liver disease (MASLD) patients in Egypt. Researchers will identify the metabolic risk factors in patients with MASLD. evaluate the effect of metabolic features on stratifying MASLD patients by predicting higher FAST score. Participants will be subjected to history taking, clinical examination, laboratory investigations, abdominal ultrasonography, and transient elastography (Fibroscan) to measure liver stiffness (LSM) and controlled attenuation parameter (CAP). The Non-alcoholic fatty liver disease (NAFLD) fibrosis score and FAST score will be calculated. |
RANIA MAMDOUH ELKAFOURY; | 2024-09-01 |
| 249 | A Prospective, Randomized, Double-Blind, Sham-Controlled, Multicenter, Pivotal Study to Assess The Efficacy of Revita® Duodenal Mucosal Resurfacing (DMR) on Body Weight Maintenance in Participants With Obesity and Who Have Achieved at Least 15% Weight Loss on Tirzepatide Obesity Pharmacotherapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The REMAIN-1 clinical trial is a prospective, pivotal, double-blind, randomized, sham-controlled trial that will investigate the superiority of Revita DMR compared with sham on the maintenance of weight loss after successfully losing at least 15% total body weight on an open-label, dose escalation, tirzepatide run-in period of approximately 16-20 weeks. Study participants are male and non-pregnant, non-lactating females, aged 21 -70 years, who do not have type 1 or type 2 diabetes mellitus, with a BMI ≥30 kg/m2. The REMAIN-1 study will consist of 4 periods: * A screening period of 1 week * An approximately 16-20-week, dose-escalation, … |
PAUL HELLSTERN JR.; | 2024-09-01 |
| 250 | Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake: A Double-blind, Randomized, Placebo-controlled, Cross-over Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigator aim to understand whether food-induced glucocorticoids influence fat mass in overweight and obese people. In a randomized, cross-over study, 23 overweight and obese volunteers will receive a block and replace therapy that mimics physiological glucocorticoid (GC) rhythm (metyrapone plus hydrocortisone) or placebo. Participants will undergo two identical overfeeding periods with each treatment. With the block and replace therapy food-induced GC peak will be suppressed. Metabolic and immunological parameters will be compared to reveal the effects of GCs during excessive overfeeding, particularly to understand changes in body fat. |
ELEONORA SEELIG; | 2024-09-01 |
| 251 | Effects of Competitive Exergame on Weight Loss, Mental Health, and Social-emotional Among Overweight and Obese Male Adolescents in China PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Overweight and obesity are prevalent, especially among adolescents. By 2016, over 124 million children and adolescents, comprising 6% of girls and 8% of boys, were classified as obese. Over the past century, childhood obesity has transitioned from a symbol of prosperity and well-being to being acknowledged as a significant health concern. Furthermore, according to the World Health Organization, it is now considered one of the most serious challenges of the 21st century. Overweight and obese adolescents have serious problems with weight loss, … |
LIU CHUNQING; | 2024-09-01 |
| 252 | A Randomized Crossover-Controlled Trial Investigating The Epigenetic Impact of A Greens-Based Supplement in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to assess changes in epigenetic markers of aging and physiological parameters in overweight older adults consuming a mixed greens-based supplement over a 30-day period in a randomized crossover design. |
ANDREW FRUGE; | 2024-09-01 |
| 253 | Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome: A Prospective Comparative Randomized Blinded Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In PCOS (Polycystic Ovary Syndrome), studies have found impaired incretin secretion and activity, particularly in overweight/obese individuals. Conflicting results exist regarding glucagon-like peptide-1(GLP-1) levels in PCOS patients, with studies reporting reduced, normal, or increased levels. Incretin-based therapy has been suggested as a potential treatment to reverse prediabetes risk by preserving β-cell function in patients with impaired fasting glucose(IFG and impaired glucose tolerance(IGT). The study aims to compare the efficacy of Dapagliflozin to Metformin for the treatment of non-diabetic patients with polycystic ovary syndrome (PCOS). |
NOURAN OMAR EL SAID; | 2024-09-01 |
| 254 | The Effect of Diet Intervention on Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity has become a global epidemic, with more than 4 billion people expected to be overweight/obese by 2035, accounting for more than half of the world’s population. Currently, there are sixteen recognized complications directly related to obesity, including gastroesophageal reflux disease. In recent years, people have increasingly paid attention to the damage caused by obesity to the stomach. In addition to gastroesophageal reflux disease, obesity also leads to various forms of gastric mucosal damage related diseases, such as gastric ulcers, chronic gastritis, intestinal metaplasia, and so on. This stuty aimed to observe the diet intervention on obesity related stomach. |
ZHANG MANNA; | 2024-09-01 |
| 255 | Effects Of Isometrics and Dynamic Handgrip Exercise Training On Cardiovascular Parameters In Hypertensive Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Essential hypertension accounts for 13 percent of total deaths worldwide, accounting for one of the major risk factors. Hypertension (high blood pressure) is when the pressure in your blood vessels is too high (140/90 mmHg or higher). Dynamic exercises, sustained hand grip contractions elicit lower systolic blood pressure and heart rate responses. So for patients undergoing exercise therapy, … |
ARISHA NOOR; | 2024-08-30 |
| 256 | A Phase Ic Clinical Study Evaluating The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DA-302168S Tablets in Overweight/Obese Subjects After Multiple Oral Administration PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of continuous oral administration of DA-302168S tablets for 28 days in overweight/obese subjects. |
WEI HU; | 2024-08-30 |
| 257 | A Randomised, Double-blind, Placebo-controlled Trial to Assess Safety, Tolerability and Pharmacokinetics of IBI362 in Chinese Obese Adolescent Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a first-in-pediatric assessment of the safety, tolerability, and pharmacokinetic characteristics of multiple doses of IBI362 in Chinese adolescent subjects with obesity. It employs a multicenter, randomized, double-blind, and placebo-controlled trial design. The study plans to enroll 36 adolescents (aged ≥12 years and \<18 years) with obesity who have experienced less than a 5% decrease in Body Mass Index (BMI) after at least 12 weeks of diet and exercise control. |
INNOVENT BIOLOGICS SUZHOU | 2024-08-30 |
| 258 | Diet Order Effects of Low Fat Vs. Low Carb Diets on Body Fat Change PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: In a previous study, participants were lived at the NIH and randomly received either a low-fat or a low-carbohydrate diet for 2 weeks and then switched to the other diet for 2 more weeks. Participants who received the low-carbohydrate diet first lost more body fat at the end of the study than those who received the low-fat diet first. Researchers want to see if they can repeat that result in a longer weight loss study when participants live at home. Objective: To test the effects of diet order in people receiving either a low-fat or low-carbohydrate diet first for 4 weeks and then immediately switched to the other diet for another 4 weeks. Eligibility: Adults aged 19 to 50 years with a body mass index of 25 or more. Design: Participants will complete the study at their homes, but there will be 3 required visits to the NIH. Participants will drink a special type of water 2 weeks before the baseline NIH visit and collect urine samples at home to measure how many calories they burn. Before the diets begin, participants will visit the NIH for baseline testing when they will have a metabolism test while relaxing in a bed with a plastic hood over their head to collect the air they breathe out. They will have scans to measure their bone density and how much muscle and body fat they have. They will give stool, blood, and urine samples. Participants will be asked to eat a specific diet for 4 weeks followed by a different diet for 4 weeks. All meals will be delivered to the participants homes. They will eat only the foods delivered. Participants will weigh themselves daily. They will wear a monitor to track their physical activity and a sensor to measure their glucose levels. They will prick their finger each morning to test a drop of blood for ketones. Participants will meet virtually as a group with the study team weekly. Participants will have two more NIH visits towards the end of each diet period…. |
VALERIE L DARCEY; | 2024-08-28 |
| 259 | A Two-Part Phase 1, Open-Label, Fixed-Sequence Study to Evaluate The Multiple Dose Pharmacokinetics of Danuglipron Following Oral Administration and The Effects of Steady-State Danuglipron on The Pharmacokinetics of Single Oral Dose of Atorvastatin and Rosuvastatin in Otherwise Healthy Adult Participants With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn the following about the study medicine, danuglipron, after multiple days of dosing in healthy adults who are overweight or obese: * how the study medicine, danuglipron, is taken up into the blood * if the study medicine, danuglipron, changes how the body processes other study medicines (Atorvastatin and Rosuvastatin) * about the safety and tolerability of danuglipron The study will take place in 4 Cohorts (groups). The total number of weeks of the study is about 23 (about 6 months) for Cohort 1 and 22 weeks (about 5.5 months) for Cohort 2, … |
PFIZER | 2024-08-28 |
| 260 | The Effect of Nutritional Counseling on Knowledge, Attitude, Health Behavior, Anthropometry, Body Composition, Lipid Profile, Uric Acid Levels, Blood Glucose, and HbA1c in Obese Female Employees At Adam Malik Hospital, Indonesia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this quasi-experimental study is to determine if nutritional counseling can improve health outcomes in obese female employees at Adam Malik Hospital in Medan. Specifically, the study aims to assess the impact of nutritional counseling on participants' knowledge, attitudes, and health behaviors, as well as on various health indicators such as anthropometric measurements, body composition, lipid profile, uric acid levels, blood glucose, and HbA1c. The main questions it aims to answer are: – Does nutritional counseling lead to improved knowledge about nutrition among participants? – … |
HILNA KHAIRUNISA SHALIHAT; | 2024-08-26 |
| 261 | A Phase I Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Study to Evaluate The Safety, Tolerability, and Pharmacokinetics of ASC30 Tablets in Participants With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase I, randomized, double-blind, placebo-controlled, single and multiple ascending dose study to evaluate the safety, tolerability, and pharmacokinetics of ASC30 Tablets in participants with obesity. |
ASCLETIS PHARMA CHINA CO | 2024-08-26 |
| 262 | A PHASE 1, OPEN- LABEL STUDY TO EVALUATE THE MULTIPLE DOSE PHARMACOKINETICS OF DANUGLIPRON FOLLOWING ORAL ADMINISTRATION IN OTHERWISE HEALTHY ADULT PARTICIPANTS WITH OVERWEIGHT OR OBESITY PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn the following about the study medicine, danuglipron, after multiple days of dosing in healthy adults who are overweight or obese: – how the study medicine, danuglipron, is taken up into the blood – about the safety and tolerability of danuglipron The total number of weeks of the study is about 15 (about 4 months). |
PFIZER | 2024-08-23 |
| 263 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled, 13-week Study of NA-931 for Weight Management in Subjects Who Are Obese or Overweight With at Least One Weight-related Comorbid Condition PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2 randomized, double-blind, placebo-controlled, parallel arm study of NA-931 in adults who are obese (BMI ≥30 kg/m2) or who are overweight (BMI ≥27 kg/m2) with at least one weight-related co-morbid condition. |
LLOYD TRAN; | 2024-08-19 |
| 264 | A Dose-Escalation Phase 1, Investigator- and Participant-Blind, Placebo-Controlled Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of LY3532226 in Participants With Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY3532226 in participants with obesity. Blood tests will be performed to check how much LY3532226 gets into the bloodstream and how long it takes the body to eliminate it following weekly or monthly administration. Part A of the study will last approximately 16 weeks, excluding screening period. Part B of the study will last approximately 20 weeks, excluding the screening period. |
HUGH COLEMAN; | 2024-08-16 |
| 265 | Effect of A Structured School-based Health Intervention for Obesity Prevention In Children Aged 5-12 Years PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed research aims to assess how well a structured intervention is intended to reduce childhood obesity. The intervention addresses food and physical activity behaviors, important determinants of obesity, by concentrating on these elements. The goal of nutritional and physical education is to raise knowledge about the negative effects of obesity and encourage healthy eating habits in children and their caregivers. These educational campaigns will be delivered primarily through schools, guaranteeing a wide audience and consistent messaging. |
ARSHED MUHAMMAD; | 2024-08-15 |
| 266 | Effectiveness of ResArgin on Adult’s Body Composition and Health: A Randomized Double-Blind Placebo-Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if the supplement ResArgin (a reservatrol-based supplement) works to slow down muscle loss during a period of fat loss. Other related health outcomes such as sleep, mood, and activity will be assessed. The main questions it aims to answer are: Does ResArgin improve muscle loss? Does ResArgin improve sleep quality, activity, mood, … |
HEATHER HAUSENBLAUS; | 2024-08-15 |
| 267 | Validation of Cuffless Blood Pressure Measurements Using The Perin Health Patch PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to validate a proprietary cuffless blood pressure algorithm using measurements from a multi-modal chest-worn medical device, the Perin Health Patch (PHP). |
IAN M MCLANE; | 2024-08-15 |
| 268 | Creation of Side-to-Side Compression Anastomosis Using The GT Metabolic Solutions Magnet System, DI Biofragmentable (MagDI System) in Australia to Achieve Duodeno-Ileostomy Diversion in Adults With Obesity and With or Without Type 2 Diabetes Mellitus (MagDI Australia Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the MagDI Australia Study is to evaluate the feasibility / performance, safety, and initial efficacy of the MagDI System in eligible participants who are indicated for a duodeno-ileal (small bowel) side-to-side anastomosis procedure for partial intestinal diversion (e.g., one example of a small bowel clinical procedure requiring a side-to-side anastomosis). |
GT METABOLIC SOLUTIONS | 2024-08-13 |
| 269 | Safety, Tolerability and Pharmacokinetics Study of Multiple Rising Subcutaneous Doses of Survodutide in Chinese Participants With Overweight or Obesity (BMI 24.0 to 40.0 Kg/m2) (Non-randomization, Open Label, Parallel Group Design) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to Chinese adults aged 18 to 60 with overweight or obesity. People can join the study if they have a Body Mass Index from 24 to 40.0 kg/m2. Survodutide is a medicine being developed to help people with overweight or obesity. The purpose of this study is to find out how different doses of survodutide are taken up in the body. Other goals are to test if participants can tolerate different doses of survodutide and whether survodutide helps people with overweight or obesity. Participants receive survodutide as an injection under the skin once a week for 7.5 months. During this time, participants visit the study site 33 times. 4 of the visits require a stay in the hospital. At the visits, doctors take blood samples to measure the levels of survodutide in participants’ blood. The doctors also check participants’ health and take note of any unwanted effects. |
BOEHRINGER INGELHEIM | 2024-08-12 |
| 270 | Effect of Consuming Flavanol-rich Cocoa on Biomarkers Associated With Digestive and Cerebrovascular Health in The Colombian Adult Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the effects of consuming flavanol-rich cocoa on biomarkers associated with digestive and cerebrovascular health in a group of adults. |
JELVER SIERRA; | 2024-08-12 |
| 271 | Investigation of The Safety, Tolerability, Pharmacokinetics and Efficacy of Subcutaneous Weekly Doses of NNC0519-0130 in Participants With Obesity and in Participants With Type 2 Diabetes With Either Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A new study medicine called NNC0519-0130 to improve treatment options for people living with excess body weight, with or without type 2 diabetes. The purpose of the study is to investigate potential side effects and blood levels of NNC0519-0130, as well as changes in body weight, blood sugar levels, and heart activity. The study consists of two groups, with participants receiving either the study medicine (NNC0519-0130) or a placebo. Which treatment participants get is decided by chance and they can only participate in one group. Participants will be given the study medicine once weekly, … |
NOVO NORDISK | 2024-08-07 |
| 272 | A Phase II, Randomized, Double-Blind, Placebo-Controlled, Clinical Study Investigating The Safety, Tolerability, and Effectiveness of The Co-Administration of Bremelanotide with Tirzepatide (GLP-1/GIP) for The Treatment of Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, randomized, double-blind, placebo-controlled study designed to assess the safety and efficacy of bremelanotide (BMT) used in combination with tirzepatide therapy in the treatment of obesity in subjects with a BMI ranging from 30.0 to 45.0 kg/m2 (inclusive). |
PALATIN TECHNOLOGIES | 2024-08-05 |
| 273 | DECIDE: A Comparative Effectiveness Trial of Oral Metformin Versus Injectable Insulin for The Treatment of Gestational Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 individuals with gestational diabetes mellitus (GDM) randomized to oral metformin versus injectable insulin. This study will determine if metformin is not inferior to insulin in reducing adverse pregnancy outcomes, is comparably safe for exposed individuals and children, and if patient-reported factors, including facilitators of and barriers to use, … |
KARTIK K VENKATESH; | 2024-08-01 |
| 274 | The Study of Association Between Obesity and Iron Deficiency Anaemia in Nonpregnant Indonesian Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to learn if there is a relationship between OWT/OB and IDA in nonpregnant women of reproductive age and its impact on iron supplementation. The main questions it aims to answer are: – Is there any independent association between overweight/obesity and iron deficiency anemia in nonpregnant women after controlling for potential confounding factors? – … |
QONITA RACHMAH; | 2024-08-01 |
| 275 | Comparing The Effect of Metformin Vs. Pep2dia As An Adjunct to Letrozole on Ovulation Induction and Pregnancy Outcomes in Overweight Women With PCOS; A Randomized Controlled Open-Label Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effects of Metformin versus Pep2dia as adjunct treatments to Letrozole on ovulation induction and pregnancy outcomes in overweight women with polycystic ovary syndrome (PCOS). The main questions it aims to answer are: Does Metformin improve ovulation rates more effectively than Pep2dia when used alongside Letrozole? Does Pep2dia enhance pregnancy outcomes compared to Metformin in this patient population? Participants will: Receive either Metformin or Pep2dia in addition to Letrozole. Undergo regular monitoring for ovulation and pregnancy outcomes. Researchers will compare the Metformin group to the Pep2dia group to see if there is a significant difference in ovulation and pregnancy rates between the two treatments. |
MUHAMED AHMED ABDELMOATY MUHAMED ALHAGRASY; | 2024-08-01 |
| 276 | Evaluating The Efficacy and Use of The Bouquet Speculum for Cervical Cancer Screening in A Diverse Population of Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The specific aim of this research is to determine if the Bouquet Speculum TM , compared to the existing 2-bladed vaginal speculum, provides better visualization of the cervix, is easier for the provider to use and is more comfortable for the patient. Additionally, the clinician’s experience with vaginal speculum exams and the patient’s last vaginal speculum exam, parity and self-reported weight classification will be surveyed to see what effect, if any, it has on visualization of the cervix, ease-of use, and comfort level for the patient. The objective of this project is to investigate the use of a novel, FDA-cleared, … |
JEAN BOUQUET; | 2024-08-01 |
| 277 | The Effect of Body Composition on Respiratory Parameters, Functional Capacity and Sleep in Healthy Young Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Body composition has a significant effect on the respiratory system. Both respiratory prediction of function and a prognostic tool evaluated in the cardiopulmonary system factor. Respiratory function, which directly affects respiratory muscle strength and respiratory muscle endurance covers a range of data. In the literature, the relationship between body composition and respiratory function. Although there are studies examining body composition in healthy young adults, the relationship between them has not been clearly demonstrated. The aim of the study was to investigate the effects of body composition on respiratory function, respiratory muscle endurance, functional capacity and sleep quality. For this purpose, … |
MELIS USUL; | 2024-08-01 |
| 278 | Effects of Aerobic Exercise on Executive Function Among Obese Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if aerobic exercise improves executive functioning in obese children. It will also understand the effects of aerobic exercise on executive functioning in obese children. The main questions it aims to answer are: 1. What are the levels of executive functioning(inhibitory function, working memory, and cognitive flexibility) in normal-weight and obese children aged 8-10 years? 2. What are the differences on executive function before and after aerobic exercise intervention among obese children? 3. Do factors of health, gender and ages influence students’ executive functioning (inhibitory function, working memory, … |
JING XIN; | 2024-08-01 |
| 279 | A Randomized, Crossover Trial to Assess The Effects of Acute Intake of Meals Containing Higher Vs. Lower Energy From Protein on Diet Induced Thermogenesis in Adults With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this trial is to assess the effects of acute intake of mixed meals containing higher vs. lower energy from protein on diet induced thermogenesis (DIT) in adults with overweight or obesity. |
MIDWEST CENTER FOR METABOLIC AND CARDIOVASCULAR RESEARCH | 2024-08-01 |
| 280 | The Impact of Dietary Protein Sources on Glycemic Variability in Overweight or Obese Individuals: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This goal of trial is to evaluate the effects of plant-based vs. animal-based diets on glycemic variability in overweight or obese adults through a 3-week dietary intervention. The main question it aims to answer is: Will a plant-based diet be able to reduce glycemic variability in overweight or obese adults compared with an animal-based diet? Participants will strictly follow a designated plant-based or animal-based dietary regimen throughout the duration of the 3-week study. They will wear a Continuous Glucose Monitor (CGM) throughout the study, engage in weekly clinical assessments, and record their daily dietary intake. |
JIE LI; | 2024-08-01 |
| 281 | A Randomized, Double-blind, Parallel Study to Examine The Effects of N-trans-caffeoyl Tyramine and N-trans-feruloyl Tyramine Bioactives on Fat Oxidation in Adult Women With Overweight and Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pilot study is to evaluate the effects of 4 weeks of daily consumption of encapsulated N-trans-caffeoyl tyramine (NCT) and N-trans-feruloyl tyramine (NFT) at a dose of 120 mg/d on measures of fat oxidation in women with overweight or obesity. The hypothesis is that fat oxidation at rest (measured via indirect calorimetry) and over a 24 h period (measured via d31-palmitic acid stable isotope tracer) will be higher in the group receiving the active study product compared to the control product at the end of the 4-week consumption period. |
BRIGHTSEED | 2024-07-31 |
| 282 | A Randomized, Double-blind, Placebo-controlled Phase I Clinical Study to Evaluate The Safety, Efficacy, and Pharmacokinetics of Multiple Oral Administration of HDM1002 Tablets in Chinese Overweight and Obese Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: • To assess the safety of multiple oral doses of HDM1002 tablets under different titrations in Chinese overweight and obese adult subjects. |
XIAOYING LI; | 2024-07-28 |
| 283 | Effect of Ultrasound Cavitation Versus Whole Body Vibration on Abdominal Fat in Obese Adolescent Females: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine the differences between the effect of ultrasound cavitation and whole-body vibration on abdominal fat in obese adolescent females |
CHRISTINA SAMIR HARMAKES; | 2024-07-22 |
| 284 | Misinterpretation of ILD In Obese Patients With OSA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Assess the impact of obesity and OSA on the interpretation of high-resolution computed tomography (HRCT) findings in patients with ILD. Identify specific challenges or confounding factors that may contribute to the misinterpretation of HRCT findings in this population. Evaluate the potential consequences of misinterpretation, including delayed or inaccurate diagnosis, inappropriate treatment decisions, and suboptimal patient outcomes. |
HEND MOHAMED SAYED MOHAMED; | 2024-07-20 |
| 285 | Multiple Dose Study to Investigate The Safety, Tolerability, Pharmacokinetics, and Efficacy of THDBH120 in Chinese Patients With Obesity: A Randomized, Bouble-Blind, Placebo-Controlled Phase Ib Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this trial is to investigate the safety, tolerability, pharmacokinetics, and efficacy of THDBH120 injection in participants with obesity. This study includes three multiple-ascending dose cohorts. |
TONGHUA DONGBAO PHARMACEUTICAL | 2024-07-18 |
| 286 | Aerobic Versus Resistance Exercises on Insulin Sensitivity in Obese Patients Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of study is to compare the effect of different exercise modes on insulin resistance and body composition in obese patients. |
EL-SAYED ESSAM; | 2024-07-18 |
| 287 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate The Safety and Efficacy of HDM1002 Tablets in Overweight and Obese Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It is a multicenter, randomized, double-blind, placebo-controlled phase II clinical trial to evaluate the safety and efficacy of HDM1002 tablets in overweight and obese adults. |
XIAOYING LI; | 2024-07-15 |
| 288 | A Randomized, Placebo-controlled, Double-Blind Phase 2 Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity, With An Open-Label Extension PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to determine how well LB54640 works and how safe it is in patients with Hypothalamic Obesity (HO). The study will evaluate the effect of LB54640 on safety, weight reduction, hunger, and quality of life in patients 12 years of age and older with HO. Patients will take an oral daily dose of either LB54640 (low, middle, or high dose) or placebo through Week 14. Eligible patients who consent to continue in the study after Week 14 will take an oral daily dose of LB54640 through Week 56. |
RHYTHM PHARMACEUTICALS | 2024-07-11 |
| 289 | Effect of Ultrasound Cavitation Versus Electrolipolysis on Obese Infertile Women With Polycystic Ovarian Syndrome: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine the difference between the effect of ultrasound cavitation and electrolipolysis on obese infertile women with polycystic ovarian syndrome. |
HEND AHMED HASSAN; | 2024-07-10 |
| 290 | The Effects of Kefir on Pediatric Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Kefir, a traditional fermented dairy product in the North Caucasus region, is produced through the fermentation of milk by lactic acid bacteria and yeast. In murine studies, it has been observed that consumption of kefir by obese mice resulted in significantly reduced body weight compared to non-kefir-consuming obese mice. Furthermore, insulin resistance and fatty liver conditions showed improvement in the kefir-fed obese mice. Kefir was found to have its effects on obesity-related conditions through the inhibition of lipid synthesis, stimulation of fatty acid oxidation, elevation of basal metabolic rate, … |
CHINA MEDICAL UNIVERSITY HOSPITAL | 2024-07-06 |
| 291 | The Influence of Acute Continuous Exercise and Adiposity on Appetite Hormones and Neural Correlates of Visual Food Cues PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Exercise increases energy expenditure and impacts appetite and energy intake. Some appetite-related hormones such as oxyntomodulin suppress appetite whilst other hormones such as ghrelin stimulate appetite. This study will investigate whether acute continuous walking/jogging influences these hormone concentrations, and whether exercise-induced changes in the hormones correlate with perceptions of appetite, nutritional intake and brain activity in individuals varying in weight status. |
DAVID STENSEL; | 2024-07-05 |
| 292 | Acute Effects of Ketone Monoester Supplementation on Brain Function in Older Men with Overweight PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Disturbances in brain insulin-sensitivity are not only observed in obesity and type 2 diabetes (T2D), but also during brain aging and in dementia. Ketone monoester supplements may improve brain insulin-sensitivity, which can be quantified by measuring the gray-matter cerebral blood flow (CBF) response to intranasally administered insulin. We hypothesize that acute ketone monoester supplementation increases (regional) brain vascular function and insulin-sensitivity thereby improving cognitive performance and appetite control. The primary objective is to evaluate in older men the acute effect of ketone monoester supplementation on (regional) brain vascular function and insulin-sensitivity, … |
PETER J JORIS; | 2024-07-03 |
| 293 | Mobile Apps for Preschool Parents (MAPP) Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of Mobile Apps for Preschool Parents (MAPP) Study is to test the effectiveness of two mobile applications for parents of preschool aged children: 1) an app focused on child and family nutrition and wellness, and 2) an app focused on parents reading to their children. |
PAMELA HULL; | 2024-07-01 |
| 294 | The Impact of Changes in Body Composition on The Retina and Choroid PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to examine the effects of body composition differences on retinal and choroidal structures. The study aims to investigate how variations in fat distribution and body composition parameters influence ocular microvascular structures. The main questions it aims to answer are: * How do differences in body composition (BMI, waist circumference, bioelectrical impedance parameters) affect retinal and choroidal microvascular structures? * Are there significant structural changes in the retina and choroid among individuals with different body composition profiles? Participants will: * Be classified into five groups based on their Body Mass Index (BMI) (underweight, … |
BAYRAM MEYDAN; | 2024-07-01 |
| 295 | Polycystic Ovary Syndrome and Urinary Tract Stones: A BMI-Adjusted Analysis in Iraqi Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational case-control study is to find out the impact of PCOS as a risk factor for the presence of urinary tract stones taking into account the BMI of women aged 18-40 years consulting the gynecology and obstetrics outpatient clinic at Al-Elwiya Maternity Teaching Hospital. The study aims to collect information from approximately 200 women with polycystic ovary syndrome and 200 volunteers who do not have PCOS. A written consent was obtained from all the participants. The information collected included age, weight, and height. In addition, focused history and clinical examination were conducted for all patients, … |
HARTH MOHAMED KAMBER; | 2024-07-01 |
| 296 | ALTERNATE DOSING PROTOCOL FOR MAGNESIUM SULFATE IN OVERWEIGHT AND OBESE WOMEN WITH PREECLAMPISA: A RANDOMIZED CONTROLLED TRIAL PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There is still no evidence of the appropriate dose to be used. Serum magnesium sulfate concentration is not measured regularly, thus we may be using sub-therapeutic level or reaching a toxic level.Overweight and obese women have different pharmacokinetics and different drug distribution, therefore, they may need higher doses of magnesium sulfate to reach therapeutic level. |
AIN SHAMS UNIVERSITY | 2024-07-01 |
| 297 | Effect of A Concurrent Physical Exercise Program on Quality of Life in Hemodialysis Patients: Uncontrolled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Concurrent physical exercise is the method of combining strength and endurance that can be worked with in one session or in an exercise program. Therefore, the researchers seek to implement it in patients suffering from chronic renal failure with hemodialysis therapy and see if concurrent physical exercise improves quality of life levels and at the same time see the response of physical fitness, body composition and biochemistry. |
PEDRO JULIAN FLORES MORENO; | 2024-07-01 |
| 298 | Investigating The Exposure of NNC0487-0111 in Different Oral Formulations and The Effect of Food Intake on Pharmacokinetics of NNC0487-0111 in Participants With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study consists of two phases: Phase A and Phase B. Participants are being asked to participate in both phases. Phase A of this study is comparing two formulations of a study medicine called NNC0487-0111 for weight control in people with overweight or obesity. Phase B of this study is testing how taking NNC0487-0111 at the same time as a meal affects the way NNC0487-0111 works in participants body. The aim of this study is to compare how two different formulations of NNC0487-0111 behave in the body, … |
NOVO NORDISK | 2024-06-27 |
| 299 | A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Proof-of-Concept Study to Investigate Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared with Tirzepatide Alone in Participants with Obesity Aged 55 Years and Over (STRIDES) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to find out how well a combination of oral azelaprag taken once a day (QD) or twice a day (BID), along with a weekly injection of tirzepatide, works for weight management in adults 55 years and older. The researchers are also looking at safety. Estimated Study Length: * with the optional prescreening, the study duration may be up to 48 weeks. * the treatment duration will be 24 weeks followed by 12 weeks follow-up. * the visit frequency will be every 2 weeks for the first 8 weeks of the treatment period and every 4 weeks thereafter. |
BIOAGE LABS | 2024-06-27 |
| 300 | A Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Dose Escalation Phase I Study to Evaluate The Safety, Tolerability, and Pharmacokinetics of LAE102 Injection in Healthy and Overweight/Obese Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of LAE102 injection in healthy and overweight/obese participants, and also evaluate the preliminary pharmacodynamic effect of multiple dose injections in overweight/obese participants. |
XUENING LI; | 2024-06-25 |
| 301 | Evaluation of The Acceptability and Usability of A Point-of-care-in-vitro Diagnostic Micro-sampling Device for Micronutrient Measurement PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood obesity is a global health crisis with 1.2 million children in England severely obese, predisposing them to multiple health risks which decrease lifespan and compromise health. Children suffering from obesity experience a state of paradoxical malnutrition; despite excessive calorie intake they have high rates of micronutrient deficiencies rates due to consumption of energy dense, nutrient poor diets. Around 70-80% of obese children are Vitamin D deficient, … |
EMMA WEBB; | 2024-06-25 |
| 302 | A Multiple-Dose Study to Investigate The Bioequivalence of Orforglipron (LY3502970) Capsules and Orforglipron Tablets in Participants With Obesity or Overweight Who Are Otherwise Healthy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to see how much of orforglipron (study drug) gets into the bloodstream and how long it takes the body to get rid of it when given as capsules compared to tablets in healthy overweight and obese participants. The safety and tolerability (side effects) of orforglipron when given as capsules and tablets will also be evaluated. The study will be conducted in two parts, with part A and B lasting up to approximately 25 and 22 weeks each respectively, including the screening period. |
ELI LILLY | 2024-06-24 |
| 303 | Efficacy and Safety of Cagrilintide S.c. in Combination With Semaglutide S.c.(CagriSema S.c. 1.0 Mg/1.0 Mg and 1.7 Mg/1.7 Mg) Once-weekly in Participants With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at how well CagriSema helps people with excess body weight lose weight. CagriSema is a new medicine developed by Novo Nordisk that combines cagrilintide and semaglutide. CagriSema cannot yet be prescribed by doctors. In the study, participant will either get CagriSema or dummy medicine and which treatment participant get is decided by chance. The study will last for about 1½ years for each participant. |
NOVO NORDISK | 2024-06-24 |
| 304 | Energy Expenditure Induced By Football Training in Overweight Middle-aged Males PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims at investigating the energy expenditure following a single Football trainning session in middle aged males. The participants will perform a soccer training session [A single training session including 60 minutes of warm up, soccer technical exercises and small-sided game] and a cotrol trial (No intervention included, only daily measurements) in randomized, repeated measures, crossover design. |
IOANNIS G. FATOUROS; | 2024-06-23 |
| 305 | A Randomized, Double-blind, Placebo-controlled, Phase Ib Clinical Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Subcutaneous (SC) Doses of HDM1005 Injection in Overweight or Obese Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, double-blind, placebo-controlled, multiple-dose, dose-escalation study in overweight or obese subjects to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) characteristics of HDM1005 injection in overweight or obese subjects. |
WEI HU; | 2024-06-20 |
| 306 | Effectiveness of A Telehealth Medical Weight Management Program Prescribing Anti-obesity Medications Paired With A Digital Behavioral Weight Management Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study compares the effectiveness of adults living with overweight or obesity taking weight management medications alone vs taking them with behavioral and lifestyle support. The primary outcome is percent body weight lost at 12-weeks. |
MICHELLE CARDEL; | 2024-06-17 |
| 307 | A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate The Efficacy, Safety, and Tolerability of Treatment With DD01 for 48 Weeks in Overweight/Obese Subjects With MASLD/MASH PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2 Study to evaluate the effect of DD01 treatment in overweight/obese patients with metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH). |
NEURALY | 2024-06-13 |
| 308 | COMPARATIVE EFFECTS of REDUCED EXERTION HIGH INTENSITY TRAINING (REHIT) VERSUS HIGH INTENSITY INTERVAL TRAINING (HIIT) on ANTHROPOMETRIC MEASURES in OVERWEIGHT and OBESE ADULTS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is a global health concern associated with an increased risk of cardio-metabolic diseases and reduced overall health. Exercise is a proven modality for managing obesity, with current focus of researches on identifying more time-efficient modes of exercise training. REHIT and HIIT have proven benefits but comparative effects of REHIT and HIIT in overweight and obese adults is yet to be determined. Hence the objective of this study is to compare the effects of reduced exertion high intensity training (REHIT) versus high intensity interval training (HIIT) on anthropometric measures (weight, waist circumference, hip circumference, waist-to-hip ratio), … |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-06-10 |
| 309 | Evaluating The Feasibility of A Dietary Weight Loss Program to Overcome Obesity and Its Comorbidity Among Arab Populations: Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to develop and test a culturally tailored online weight loss program for the Saudi population. Building upon the success of a previous program in the United States, the research team will adapt educational materials and conduct a pilot study to assess the feasibility and initial outcomes of the program among Arab participants. The study seeks to answer questions about the program’s acceptability, effectiveness, and scalability, with the ultimate goal of combating obesity and its related health issues in Saudi Arabia. |
ASMA YAHYA; | 2024-06-10 |
| 310 | Intensive Weight Loss Intervention Versus Usual Care for Adults With Obesity: The LightCARE Randomised Trial. Lighthouse Consortium on Obesity Management (LightCOM) Trial No 2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with existing weight management programmes within primary care for people with obesity class I or uncomplicated obesity class II or higher. |
CARSTEN DIRKSEN; | 2024-06-05 |
| 311 | Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo for The Treatment of Obesity and Weight-Related Comorbidities in Adolescents: A Randomized, Double-Blind, Placebo- Controlled Trial (SURMOUNT-ADOLESCENTS-2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to assess how tirzepatide impacts bodyweight and cardiovascular risk factors when used in conjunction with healthy nutrition and physical activity in adolescents with obesity and multiple weight related comorbidities. The study will last approximately 76 weeks and may include up to 23 visits. |
ALAINA VIDMAR; | 2024-06-03 |
| 312 | Effect of The 4-7-8 Breathing Technique on Pain and Nausea-Vomiting in Patients After Bariatric Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is planned as a randomized controlled trial to determine the effect of the 4-7-8 breathing technique applied to patients after bariatric surgery on pain and nausea and vomiting. The research will be conducted on 60 patients who underwent bariatric surgery between 05.2024-12.2024. Randomization will be ensured for students who meet the inclusion criteria, and they will be divided into two random groups: the experimental group (n=30) and the control group (n=30). After obtaining consent with the Informed Consent Form, patients who agree to participate in the study will have the Patient Introduction Form filled out by researchers, … |
EDA ÖZYÜREK; | 2024-06-03 |
| 313 | A Multi-site, Prospective Registry of Patients Undergoing Gastric Fundal Mucosal Ablation at True You Weight Loss PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to construct a multi-site, prospective registry to evaluate the clinical outcomes of patients who have undergone gastric fundus mucosal ablation at True You Weight Loss. |
TRUE YOU WEIGHT LOSS | 2024-06-01 |
| 314 | ESPEN-EASO Sarcopenic Obesity (OS) Diagnostic Criteria Application in A COPD Cohort and OS Correlation to Diaphragmatic Thickness and Mobility for Determination of Tailored Pulmonary Rehabilitation Program: An Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to the purpose is to apply of ESPEN/EASO criteria for the diagnosis of sarcopenic obesity and calculation of OS prevalence in a sample of COPD patients. In addition, this study want to evaluate the impact of sarcopenic obesity on the respiratory function of COPD patients and the degree of severity of respiratory disease, assessed by spirometric examination; diaphragm thickness and excursion, by ultrasonographic study; performance, assessed by six-minute walk test (6-MWT); quality of life and degree of dyspnea (mMRC, Barthel dyspnea, S. George Respiratory Questionnaire); … |
IRCCS SAN RAFFAELE ROMA | 2024-06-01 |
| 315 | Effect of Soleus Muscle Push Ups on Oxidative Stress and Inflammatory Markers, Soleus Endurance, and Adipocytokines Between Type 2 Diabetic, Overweight/Obese and Normal Weight Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to investigate the impact of Soleus Push Ups (SPU) on Soleus Muscle endurance, Oxidative Stress Markers, Inflammatory markers and Adipocytokines among people in the United Arab Emirates. This will be a pre-post intervention study with participants divided into three groups: Lean normal metabolic profile, metabolically healthy overweight/obese, and patients with Type 2 Diabetes Mellitus. Assessment of anthropometry and body composition, Soleus Muscle Endurance, blood tests for Inflammatory Markers, Oxidative Stress Markers, and Adipocytokines will be conducted pre and post-intervention. |
AMENAH HISHAM ABDELAZIM; | 2024-06-01 |
| 316 | A Phase 1b, Randomized, Double-Blind, Parallel, Placebo-Controlled Study to Evaluate The Effects of XEN-101 on Safety, Tolerability, and Pharmacodynamics in Subjects With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase 1b study will evaluate the effects of XEN-101 in subjects with obesity |
XENO BIOSCIENCES | 2024-06-01 |
| 317 | Changes in The Lipidomic, Immunological and Circulating MicroRNA Profile in Patients With Hepatobiliary Pathology, Suffering From Morbid Obesity Undergoing A Dietary Program or Bariatric Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is a chronic disease characterized phenotypically by an increase in body weight (BMI\>30 kg/m2) and by a series of associated pathologies, such as hypertension, diabetes, hepatic steatosis. The association of these pathologies compromises the patient’s survival and quality of life. The multifactorial origin of obesity makes its etiopathology difficult to manage. It is often possible to follow only one therapeutic strategy, especially after the so-called standard treatments, such as dietary intervention and physical activity, have not brought benefit to the patient. In these cases, … |
ROSSELLA DONGHIA; | 2024-06-01 |
| 318 | The Effect of Preoperative Subcutaneous Trochanteric Fat Thickness and Trochanteric Soft Tissue Thickness on Postoperative Infection Risk in Patients Undergoing Hemiarthroplasty for Femoral Neck Fracture PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Obesity is a growing problem for healthcare systems and orthopaedic surgeons, with 29% of the adult population in the UK and 40% in the US affected by obesity. The most commonly … |
ANKARA CITY HOSPITAL BILKENT | 2024-05-30 |
| 319 | Relationship of Motor Competence, BMI and Physical Fitness of School Going Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The term physical fitness in youngsters describes their general health and capacity for movement. It consists of elements including flexibility, muscular strength and endurance, cardiovascular endurance, and body composition. Children that are physically fit can run, jump, climb, and play without becoming fatigued easily. The body mass index is a metric used to determine how much a person weighs in connection to their height. Motor competence assesses an individual’s ability to accomplish various motor skills and movements. The project aims to study the development and competency of motor skills, as well as factors influencing them, … |
RIMSHA MAJID; | 2024-05-28 |
| 320 | Effect of Plant Sterols on Inflammatory, Endothelial Function and Oxidative Stress Markers, Microbiota and Sterol Metabolism in A Cardiovascular Risk Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Potential cholesterol-lowering effect of a regular intake of a plant sterol (PS)-containing food supplement, in overweight/obese type 1 or 2, normoglycemic/pre-diabetic, with LDL-cholesterol values > 115 mg/dl and not pharmacologically treated participants treated with the PS-containing food supplement or placebo supplement. |
GUADALUPE GARCÍA LLATAS; | 2024-05-21 |
| 321 | The Usefulness of Circulating Microvesicles (Host and Bacterial) in Regulating Metabolic Homeostasis in Obesity Randomized Study of Parallel Arms in Obese Patients Undergoing Caloric Restriction Diet Vs. Early Time-restricted Eating PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the present study is to evaluate the effectiveness of two dietary protocols: Daily Caloric Restriction (DCR) and Early Time-Restricted Feeding + DCR (eTRE) on metabolic homeostasis and the influence of circulating extracellular vesicles (EVs) as inter-organ communication elements in obese patients. |
JUAN JOSÉ VENDRELL ORTEGA; | 2024-05-20 |
| 322 | Impact of Different Interval Training Protocols on Physical, Cardio-metabolic, Lipidomic, Hematological and Psychological Parameters in Young Overweight/Obese Girls PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to compare the impact of 12-week moderate-intensity interval training (MIIT) versus combined MIIT with high-intensity interval training (HIIT) on physical fitness, cardio metabolic, lipidomic, hematological and psychological characteristics in young overweight/obese girls. |
ASSOCIATION TUNISIENNE D’ETUDE & DE RECHERCHE SUR L’ATHÉROSCLÉROSE | 2024-05-20 |
| 323 | THE EFFECTS OF 8-WEEK HYDROGEN-RICH WATER CONSUMPTION ON BODY COMPOSITION, APPETITE AND OBESITY-SPECIFIC QUALITY OF LIFE, AND CIRCULATING GLUCAGON-LIKE PEPTIDE-1 IN OBESE MEN AND WOMEN (HYDRAPPET): A RANDOMIZED CONTROLLED TRIAL PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main goal of this study is to investigate how dihydrogen supplementation impacts body composition, appetite, quality of life specific to obesity, and levels of the hormone GLP-1 in men and women with obesity. This randomized controlled trial aims to explore whether dihydrogen can improve these health indicators. |
SERGEJ OSTOJIC; | 2024-05-15 |
| 324 | Futuros Fuertes 2.0 A Primary Care Based Intervention to Prevent Obesity Among Low-income Latino Children PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate the impact of a primary care based intervention to promote optimal feeding, screen time and sleep practices among low-income Latino infants and toddlers. Infants and caregivers will receive brief health education and coaching sessions from health educators at primary care visits in the first two years of life as well as two text messages per week with health information and tips. Half of the participants will receive the Futuros Fuertes 2.0 intervention that includes health coaching and education on infant feeding, … |
AMY BECK; | 2024-05-13 |
| 325 | A Phase I Clinical Trial in Healthy and Overweight/Obese Subjects to Investigate The Safety, Tolerability and Pharmacokinetics of Mulberry Twig Alkaloids PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial is conducted in China. The aim of the trial is to investigate safety, tolerability, and pharmacokinetics of the Mulberry Twig Alkaloids tablets (WH006) in healthy ，overweight and obesity subjects. |
YING GAO; | 2024-05-13 |
| 326 | Creation of Side-to-Side Compression Anastomosis Using The GT Metabolic MagDI System in Canada to Achieve Duodeno-Ileal Diversion in Adults With Obesity and With or Without Type 2 Diabetes Mellitus (MagDI Canada Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the MagDI Canada study is to evaluate the performance and safety of the MagDI System in eligible participants who are indicated for a duodeno-ileal (small bowel) side-to-side anastomosis procedure for partial intestinal diversion as one example of a small bowel clinical procedure requiring a side-to-side anastomosis. The secondary objective includes initial efficacy of the duodeno-ileal diversion using the MagDI System. |
GT METABOLIC SOLUTIONS | 2024-05-10 |
| 327 | Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: The LightBAR Randomised Trial. Lighthouse Consortium on Obesity Management (LightCOM) Trial No 4 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: With this trial, the aim is to assess the benefits and harms of a non-surgical intensive weight loss intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with bariatric surgery for people with severe and complex obesity. The interpretation of the results will help inform future care pathways for people with obesity in whom bariatric surgery is currently the only available effective treatment option. |
CARSTEN DIRKSEN; | 2024-05-08 |
| 328 | A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of NA-931 in Overweight/Obese Participants and in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, double-blind, placebo-controlled, dose escalation, first in human study designed to assess the safety and tolerability, pharmacokinetics, and pharmacodynamics of NA-931 when administered as single and multiple-ascending doses in overweight/obese participants and as multiple doses in patients with T2DM. |
BIOMED INDUSTRIES | 2024-05-06 |
| 329 | Liraglutide for Management of Obesity in People Living With HIV on Dolutegravir-based Antiretroviral Therapy: A Single-arm Acceptability Study in South Africa PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this single-arm, open label pilot study is to evaluate liraglutide at the recommended dosage administered subcutaneously + lifestyle counselling for the management of people living with HIV (PLWH) with obesity defined by a BMI ≥30 kg/m2 who are on dolutegravir-based ART. Following individual informed consent, all participants will undergo a series of basic cardiometabolic labs. They will then be initiated on liraglutide 0.6 mg administered subcutaneously, and this dose will be gradually increased over a period of 4 weeks to a dose of 3.0 mg daily. Alongside drug administration, … |
JENNIFER M. MANNE-GOEHLER; | 2024-05-02 |
| 330 | Impact of FTO Gene Variation on Body Composition, Lipid Profile, Insulin Resistance, Advanced Glycation End-Products and Ghrelin Levels in Response to Hypocaloric, Protein Rich-Diet PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is a widespread disease that basically develops from unhealthy lifestyle and genetics. The Fat-mass and obesity associated (FTO) gene affects appetite and energy intake of the body, thus elevating fat mass and body weight. The single nucleotide polymorphism (SNP) rs9939609 of the FTO gene is a common variant in different ethnic groups, and its A allele is associated with increased body mass and waist circumference. Hence, the carriers of rs9939609 SNP are prone to weight gain if a healthy diet and lifestyle are not maintained. Similarly, high levels of serum cholesterol and triglycerides, … |
BIBI HAJIRA; | 2024-05-01 |
| 331 | Serum YKL-40 Levels Is Associated With Nutritional and Oxidative Status of Hemodialysis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background YKL-40 is a glycoprotein that had been reported to be associated with inflammation atherosclerosis and endothelial dysfunction. The objective is to explore the association of serum YKL-40 levels with nutrition status, inflammation, and body composition in a cohort of hemodialysis patients Methods We plan to recruit 400 prevalent HD patients. Their baseline serum YKL-40 levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, and nutritional indices will be measured. |
PAIK SEONG LIM; | 2024-05-01 |
| 332 | Using Digital Health Technologies to Prevent Obesity Among Infants of Parents Receiving Nutrition Assistance Benefits PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this research is use digital health to augment the clinical encounter with Women, Infants, and Children (WIC) clinicians and prevent rapid infant weight gain among children living in low-income households. Intervening on weight gain during infancy offers an opportunity to influence lifelong obesity risk. Using personalized motivational messages and targeted skills-training resources, the intervention will support parents and caregivers in adopting responsive feeding strategies. Knowledge gained from this project will be used to develop a future, larger grant submission focused on developing healthy feeding and eating habits among mother-infant dyads. |
MELISSA C KAY; | 2024-05-01 |
| 333 | Effect of 4 Weeks of Oral D. Piger on Safety, Pharmacokinetics and Ethanol Metabolism in Overweight Individuals (2023) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to determine the effect of supplementation of the d piger strain on intestinal ethanol production in individuals with overweight. The investigators will perform a randomized trial in 2×10 participants to measure effects on ethanol in blood, and perform fecal analyses. |
MAX NIEUWDORP; | 2024-05-01 |
| 334 | Non-invasive Brain Stimulation to Prepare The Patient for Bariatric Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is a chronic metabolic condition characterized by excessive accumulation of body fat, which triggers physiological mechanisms that increase the risk of a wide range of health problems. The most effective treatment for severe obesity is metabolic-bariatric surgery, which can lead to a 15-20% weight reduction, significantly lowering the risks of illness and death. However, the success of this surgery can be threatened by poor eating habits after the procedure. The main goal of this study is to enhance the long-term effectiveness of bariatric surgery by combining it with non-invasive brain stimulation (tDCS) targeting inhibitory centers before the operation. Additionally, … |
IRENA REKTOROVÁ; | 2024-05-01 |
| 335 | Diabetes Prevention Program Feasibility Study of Breastfeeding – Electronic Monitoring of Mom’s Schedule 2.0 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the impact of a comprehensive intervention that combines breastfeeding support with a diabetes prevention-based program (DPP) on postpartum weight retention and lactation duration among women with pre-pregnancy overweight or obesity. This intervention, named eMOMS, is delivered by a certified health coach via a mobile health (mHealth) application. |
LISETTE JACOBSON; | 2024-04-30 |
| 336 | Effect of Rotator Cuff Training on Hand Grip Strength and Endurance in Adults With Different Body Mass Index PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose of the study: – To investigate the effect of rotator cuff training on hand grip strength in adults with different body mass index. – To investigate the effect of rotator cuff training on hand grip static endurance in adults with different body mass index. – To investigate the effect of rotator cuff training on hand grip dynamic endurance in adults with different body mass index. – To investigate the effect of rotator cuff training on upper limb function in adults with different body mass index. |
NADA ATEF MOHAMMED MOHAMMED; | 2024-04-30 |
| 337 | A Single-dose, Randomized, Placebo-controlled Phase I Study on The Effects of A Subcutaneous Dose of BI 1820237 and BI 456906, and Combination Thereof on Functional MRI Measurements in Otherwise Healthy Male and Female Individuals With Obesity/Overweight (Single-blind, Cross-over Design) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this trial is to investigate the effect of BI 1820237 alone, BI 456906 alone, combination of BI 1820237 and BI 456906 versus placebo on brain activity. |
BOEHRINGER INGELHEIM | 2024-04-30 |
| 338 | Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity: The LightWAY Randomised Trial: Lighthouse Consortium on Obesity Management (LightCOM) Trial No 3 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with existing weight management programmes within primary care for people with severe and complex obesity. |
CARSTEN DIRKSEN; | 2024-04-29 |
| 339 | Movement Behaviours Among Bahraini Type 2 Diabetic Adults: A Cross-sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational study aims to measure movement behaviours and explore factors influencing these among Bahraini patients with type 2 diabetes. The main objectives are: (i) Measure free-living physical activity and sedentary behaviour with an accelerometer device (ii) Examine associations between movement behaviours and anthropometric and diabetes-related biochemical/clinical parameters (iii) Examine associations between movement behaviours and psychological and environmental determinants that influence movement behaviours (iv) Assess the feasibility and acceptability of the physical activity assessment tools as part of routine clinical practice with clinicians and diabetic patients Participants will be invited to wear an accelerometer device for seven days. |
EBRAHIM RAJAB; | 2024-04-24 |
| 340 | A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study of Once-Weekly Tirzepatide Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine if combining tirzepatide with mibavademab will result in more weight loss in adult participants than tirzepatide alone. The study will last about 74 weeks and may include up to 19 visits. |
ELI LILLY | 2024-04-24 |
| 341 | A Phase 1, Open-label, Randomized, Parallel-group, Single-dose Study to Evaluate The Pharmacokinetics, Safety, and Tolerability of AMG 133 Administered Subcutaneously in Chinese Subjects With Obesity or Overweight PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to assess the pharmacokinetics (PK) of AMG 133 after a single subcutaneous (SC) administration in overweight or obese Chinese participants. |
AMGEN | 2024-04-24 |
| 342 | The Effect of Sodium Glucose Co-transporter 2 Inhibitor (dapagliflozin) on Weight Loss in Non-diabetic Adults with Obesity: Triple-blinded, Randomized, Placebo-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effectiveness of a drug named dapagliflozin (tested drug) on weight loss in young adults aged between 18 and 40 years with obesity who are not diagnosed with diabetes. The main questions this study aims to answer are: * How much weight in average can people loose with the use of tested drug compared to 2 other comparator drugs: metformin and placebo (non-medicated pill)? * What is the effect of using tested drug on other parameters used to assess metabolic disease including blood pressure, cholesterol and sugar levels, … |
THURAIYA MALIK AL HARTHI; | 2024-04-22 |
| 343 | A Randomized, Double-Blind, Placebo-controlled Study of Efsubaglutide Alfa on Weight Management in Subjects With Overweight or Obesity to Evaluate The Safety, Pharmacokinetics and Pharmacodynamics, and Efficacy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of Efsubaglutide Alfa at difference dose range once-weekly in patients with Overweight or Obesity. |
WEIPING JIA; | 2024-04-21 |
| 344 | High Intensity Interval Exercise Versus Focused Ultrasound on Insulin Resistance in Diabetic Female Patients With Abdominal Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity and diabetes share a common insulin resistance pathway and contribute to chronic hyperglycemia. Both high-intensity interval exercise (HIIE) and focused ultrasound (FUS) have been explored in the context of managing insulin resistance in diabetic individuals with abdominal obesity, though they operate through different mechanisms and have different implications. |
NOHA AHMED FOUAD ABD-ELRAHMAN; | 2024-04-16 |
| 345 | A Multiple-Ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3841136 Monotherapy, and LY3841136 in Combination With Tirzepatide, in Japanese Participants With Obesity or Overweight PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to learn about the side effects of LY3841136 alone and in combination with tirzepatide, when given to Japanese participants with obese or overweight. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. Part A of the study will last about 28 weeks and may include up to 17 visits. Part B of the study will last about 40 weeks and may include up to 29 visits. |
ELI LILLY | 2024-04-15 |
| 346 | Effect of Consumption of Pep19 on Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pep19 is a naturally occurring peptide (protein) that triggers loss of body fat. It has been certified Generally Recognized as Safe (GRAS) at up to 3.8 grams per day and may be included in various foods. Pep19 has no effect on the brain, heart, pancreas or skeletal muscle. It is highly purified, not allergenic or mutagenic, and free of microbes, metals and other contaminants. Preliminary, open-label, uncontrolled studies have shown that Pep19 is well tolerated in rodents, dogs, and humans. This placebo-controlled study will evaluate the effects of two doses of Pep19™ — 2 mg and 5 mg – … |
JASON HAFFIZULLA; | 2024-04-15 |
| 347 | A Pilot Randomized Clinical Trial of Walking, Dance, and Abdominal Core Workouts to Improve Adipocytokines Among Insufficiently Active Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The phenomenon of physical activity (PA) avoidance in obesity has been detailed in the literature, but there is a lack of programs designed to address the root causes. In addition to common PA barriers such as lack of time, individuals with obesity face weight-related impediments, including stigma, shame, poor fitness, and low exercise self-efficacy, which reduce their engagement in PA. These impediments have been observed in white and minoritized populations. Numerous studies have suggested that individuals with obesity prefer activities that are enjoyable, less exhausting, … |
JACOB KARIUKI; | 2024-04-11 |
| 348 | Effects of The EatWelLog App on Enhancing Daily Diet Management for Community-dwelling Older Adults With Sarcopenic Obesity: A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sarcopenic obesity, characterised by concurrent reduced muscle mass and excess body fat, affects 11% of older adults worldwide, rising to 23% in those over 75. Considering the negative synergistic impact on health, promoting muscle mass gains while reducing fat mass remains a significant challenge, necessitating urgent and effective intervention strategies for managing SO. Exercise and nutrition are the primary interventions recommended for SO. This project aims to evaluate the effects of the EatWellLog App developed by the investigators’ team for local older adults, in improving: * their sarcopenic obesity status, measured by all four diagnostic criteria, including grip strength, … |
JUSTINA LIU YAT WA; | 2024-04-08 |
| 349 | Effects of Single-dose Semaglutide on Cognition and Energy in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1RA). It is a safe medication approved for use in type-2 diabetes mellitus (T2DM) and obesity. Primarily, it works by counteracting insulin-resistance and inducing weight loss. It also acts on several other interconnected neurobiological, immunological (esp. inflammatory), endocrine-metabolic, and gut-brain axis processes that play a role in depressive symptoms. Its effects on cognition and energy are currently unknown. In this study we are using semaglutide as an experimental tool to further investigate these relationships. |
UNIVERSITY OF OXFORD | 2024-04-08 |
| 350 | Nutritional Intervention to Evaluate The Effectiveness of The Consumption of Dehydrated Olive Pulp in Reducing Total Cholesterol Levels in Subjects With Overweight-obesity and High Total Cholesterol Levels PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this nutritional intervention is to assess the efficacy of polyphenol-rich capsules on reducing metabolic syndrome traits, mainly cholesterol levels. For this purpose, a double blind, placebo controlled study of 12 weeks will be carried out. The target population is women and men with overweight or obesity. Researchers will compare the experimental capsules with placebo capsules, but will be blinded during the intervention and results analyses. Only after analysing the parameters, the groups will be revealed. |
CLINICA UNIVERSIDAD DE NAVARRA UNIVERSIDAD DE NAVARRA | 2024-04-03 |
| 351 | Addressing Appetitive Traits to Promote Weight Management in Children Who Overeat PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this proposed study is to compare Regulation of Cues (ROC), Family-Based Treatment (FBT), ROC+ nutrition education and reducing energy intake (ROC+) and a health education comparator (HE) for children with overweight or obesity who are high on food responsiveness (FR). |
KERRI BOUTELLE; | 2024-04-03 |
| 352 | A Multiple Dose Combination Study to Evaluate The Safety and Tolerability of Tirzepatide and LY3841136 in Overweight and Obese Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the safety and tolerability of LY3841136 when administered in combination with tirzepatide in overweight and obese patients. The study will last up to approximately 42 weeks. |
ELI LILLY | 2024-04-03 |
| 353 | Multicentre, Randomised, Double-blind, Placebo-controlled, 48-week, Phase III Trial to Evaluate The Efficacy and Safety of Survodutide Administered Subcutaneously in Participants With Overweight or Obesity and Presumed or Confirmed Nonalcoholic Steatohepatitis (NASH) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults who are at least 18 years old and have * presumed or confirmed NASH together with overweight or obesity and * a body mass index (BMI) of 30 kg/m² or more, … |
BOEHRINGER INGELHEIM | 2024-04-02 |
| 354 | Development and Evaluation of Nutritional Strategies to Reduce and Prevent Obesity in Shiftworkers PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Shift work is a well-known risk factor for the development of overweight and obesity, which may lead to downstream effects such as increased risk of cardiometabolic diseases and cancer. However, the biological and behavioral mechanisms underlying the obesogenicity of night shift work are not well understood. Population-based mechanistic studies in real life shift workers are needed to address how night shift work impacts metabolic health. The investigators aim to characterize the behavioural, environmental, … |
KARL-HEINZ WAGNER; | 2024-04-01 |
| 355 | Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema 2.4 Mg/2.4 Mg) Once Weekly Versus Semaglutide 2.4 Mg, Cagrilintide 2.4 Mg and Placebo in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look if CagriSema can lower kidney damage in people with chronic kidney disease (CKD), type 2 diabetes (T2D) and overweight or obesity. CagriSema is a new investigational medicine. CagriSema cannot yet be prescribed by doctors. The study will compare CagriSema to the 2 medicines semaglutide and cagrilintide, when they are taken alone. It will also compare CagriSema to a dummy medicine (also called placebo) without any active ingredient. Participant will either get CagriSema, semaglutide, … |
NOVO NORDISK | 2024-04-01 |
| 356 | Effects of Time-Restricted Eating With Lactobacillus Plantarum LP-KFY04 Supplementation on Overweight / Obese Individuals : A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: With the improvement of the quality of life, multi-nutritional dietary intake today has provided people with a solid foundation for their health profiles. Time-restricted eating is found to be an effective method to prevent and control obesity, helping obese patients to lose weight in a way of reshaping the gut microbiota. Regulation of gut microbiota, as a valid weight-loss strategy, can be achieved by oral supplementation of probiotics. This study aims to evaluate the effectiveness of time-restricted eating combined with Lactobacillus Plantarum LP-KFY04 on overweight/obese population through a multi-center, randomized and double-blind clinical trial. |
HONG CHEN; | 2024-04-01 |
| 357 | A Phase 1/2 Randomized Placebo-Controlled Double-Blind Study to Investigate The Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Doses of MET097 in Adult Participants With Obesity and Overweight But Otherwise Healthy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this Phase 1/2 clinical trial is to assess the safety, tolerability, pharmacokinetics, and efficacy of once-weekly subcutaneous injections of MET097 in otherwise healthy adults with overweight or obesity. The trial will be conducted in three parts. Part A consists of single ascending dose (SAD) cohorts of MET097 or placebo. Part B consists of multiple ascending dose (MAD) cohorts, with participants treated with five once-weekly doses of MET097 or placebo. In Part C, participants will receive once-weekly doses of MET097 or placebo for 12 weeks, … |
METSERA | 2024-04-01 |
| 358 | Association Between Triglycerides Glucose Ratio With HOMA -IR As Indicators of Insulin Resistance in Obese Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present study was to investigate the correlation between the triglyceride/glucose index (TyG index) and homeostasic model assessment of insulin resistance (HOMA-IR) to predict insulin resistance (IR) in obese adults |
AYAT ESMAT MOHAMED KOTB; | 2024-04-01 |
| 359 | The Effects of Combined Energy and Carbohydrate Restriction on Exercise Capacity and Health in Overweight Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The effect of calorie restriction combined with low or moderate carbohydrate availability on exercise capacity, metabolism and metabolic health indicators will be measured in a randomized parallel group design. Forty overweight (BMI 25-30) and relatively inactive women (20-35 of age) will be included. These will be randomized into one of two experimental groups both receiving a calorie-restricted diet (-1000 kcal) combined with either low carbohydrate availability or moderate carbohydrate availability across a 10 day period. Laboratory-based physical capacity tests and blood and muscle sampling will be performed before and after the intervention. In addition, … |
UNIVERSITY OF AARHUS | 2024-04-01 |
| 360 | Obiasity Study: Evaluation of Body Composition in Pediatric Patients With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent decades, the prevalence of obesity and overweight has dramatically increased globally, representing a serious problem for society and for the health system of many countries, estimating an impact of 2-8% on global health spending. Obesity and overweight represent a problem not only for adults but also for children and adolescents: the latest data from the WHO estimate that about 340 million children and adolescents between 5 and 19 years are overweight or obese, … |
SIMONETTA BELLONE; | 2024-04-01 |
| 361 | SENSing Inner BodiLy State: Understanding The Role of Interoception in ObEsity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Successfully perceiving the flow of interoceptive cues and integrating them with exteroceptive information are fundamental aspects of countering the body’s inherent instability and guaranteeing homeostatic regulation. This process deeply affects cognitive/emotional functioning and general health. Recently, it has been suggested that an important signature underpinning obesity might be an interoceptive dysfunction in perceiving internal body signals and/or integrating them with information from the external environment. There is evidence that interoceptive deficits correlate with Body Mass Index (BMI), … |
FEDERICA SCARPINA; | 2024-04-01 |
| 362 | An Imaging-based Quantitative Biomarker Assay for Non-alcoholic Fatty Liver Disease (NAFLD) in Children: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will validate recently developed Magnetic Resonance Imaging (MRI) and Ultrasound (US) based methods for liver fat quantification in children with obesity and healthy range of body mass index (BMI). |
IVAN ROSADO-MENDEZ; | 2024-04-01 |
| 363 | Acute Changes in Cardiometabolic and Neurocognitive Outcomes in Response to Exercise Combined With Ketone Ester Supplement in Overweight/Obese Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine the acute changes in cardiometabolic and neurocognitive outcomes in response to exercise combined with ketone ester supplement in overweight/obese adults. |
ZHAOWEI KONG; | 2024-04-01 |
| 364 | The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults: A Neurophysiological and Resting Functional Magnetic Resonance Study (rfMRI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to compare the effect of a ketogenic diet versus ketone ester supplementation on motor cortex plasticity, resting brain function and structure, and metabolic and neuroendocrine responses. |
ZHAOWEI KONG; | 2024-04-01 |
| 365 | Postprandial Inflammation and PeaNuts in Older Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice, but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain and inflammation. Given these findings, this study will examine the postprandial effects of meals with 2 levels of saturated fatty acids (SFA) on metabolic endotoxemia, inflammation and satiety, … |
SUE A. SHAPSES; | 2024-03-25 |
| 366 | An Investigation of The Effect of Cagrilintide and Semaglutide Combination Treatment(CagriSema) on Energy Intake, Appetite and Gastric Emptying in People With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research study tests if CagriSema influences food intake, appetite and emptying of the stomach in people with excess body weight. Participant will either get CagriSema (active medicine) or placebo (a dummy medicine), which has no effect on the body. The treatment participants get is decided by chance. The study will last for about 32 weeks. |
NOVO NORDISK | 2024-03-23 |
| 367 | Can Hazelnut Flour Added to Gluten-free Corn Flour in Different Amounts Cause Differences in Blood Glucose Fluctuations? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One of the factors affecting human health is nutrition. The effects of foods on blood glucose are still under investigation. The Glycemic Index (GI), which is associated with many diseases today, is a value that measures the rate at which carbohydrate-containing foods raise blood glucose. It is thought that the loaves of bread produced will be a product with low GI value and can be consumed by celiacs and diabetics. It is aimed to investigate the effect of adding different amounts of hazelnut flour to bread recipes using gluten-free corn flour on blood glucose. |
FATIH CESUR; | 2024-03-21 |
| 368 | An Integrative Study of The Role of The Microbiome, Metabolome, Transcriptome and Chronobiology in The Context of Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this descriptive clinical study is to investigate daily oscillations in glycaemic control between healthy adults and adults with excess weight and who have early-stage prediabetes or T2D and are not taking medications for glycaemic control. The study also explores how these differences relate to changes in daily patterns in oral microbiome and metabolome, circadian markers, and lifestyle factors such as eating, physical activity, light exposure and appetite. The main questions to answer are: 1. Do adults with excess weight and prediabetes/T2D exhibit a disruption of the circadian system compared to healthy individuals? If so, … |
PEDRO GONZÁLEZ-MUNIESA; | 2024-03-21 |
| 369 | The Efficacy and Safety of A Probiotic in Reducing Body Fat and Blood Lipids Among Overweight and Obese Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the effects of Bifidobacterium breve BBr60 on key health indicators in overweight and obese adults. Specifically, it will assess the probiotic’s impact on body composition metrics such as BMI, body fat percentage, WHR, and BMR. The inclusion criteria for participants are a BMI of ≥28 kg/m^2, targeting individuals who stand to benefit significantly from metabolic and body composition improvements. |
WECARE PROBIOTICS | 2024-03-20 |
| 370 | A Randomized, Double-Blind, Phase 1 Study to Investigate The Effect of LY3437943 Versus Placebo on Calorie Intake and Energy Expenditure in Participants With Obesity Under Calorie Restriction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of the study is to look at the effect of the study drug compared to placebo on calorie intake, energy metabolism, and appetite. The study will last up to 6 months and may include up to 20 visits. |
ELI LILLY | 2024-03-20 |
| 371 | Investigation of The Safety and Efficacy of Once Weekly NNC0519-0130 in Participants With Overweight or Obesity – A Dose Finding Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at how a new medicine called NNC0519-0130 helps people with excess body weight lose weight. The study will test up to 6 different doses of NNC0519-0130. Participants will take 1-2 injections once a week. The study medicine will be injected under skin with a thin needle in the stomach, thigh, or upper arm. The study will last for about 42 weeks. |
NOVO NORDISK | 2024-03-18 |
| 372 | Impact of Front-of-package Labels on Weight Bias Among Latine and Limited English Proficiency Populations PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this experiment is to examine the effects on explicit weight bias of a selection task using 4 different types of front-of-package food labels to select healthy or unhealthy foods among a sample of Latine and low English proficiency adults. The main questions this experiment aims to answer are: – Does the use of different front-of-package label designs in a selection task lead to different effects on explicit weight bias among Latine and low English proficiency consumers? – … |
ALINE D’ANGELO CAMPOS; | 2024-03-15 |
| 373 | Effect of Obesity on Extracellular Matrix Composition in Healthy Males With Normal and High BMI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The experiment is a simple cross-sectional study with three groups (n=10) in each group, young and old healthy men and obese young men. The study will investigate the composition of the adipose tissue extra cellular matrix. The main questions to answer, – is there differences in the adipose tissue extracellular matrix in obese compared to young men is there differences in the adipose tissue extracellular matrix in old compared to young men |
JØRN WULFF HELGE; | 2024-03-15 |
| 374 | Implementing Strategies for Eating Behaviour Modification Based on Portion Control: Methodological Development and Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pre-post intervention study designed to evaluate the feasibility of a self-applied weight management intervention based on portion control. A total of 40 healthy volunteers with overweight/obesity will take part in a 6-month intervention featuring 4 components: a portion control toolset; a manual including instructions for the use of the tools, dietary and activity recommendations, and behavioural strategies; a mobile app to motivate intervention engagement; and biweekly telephone support. The primary outcome will be Intervention adherence, assessed as the change in dietary energy density, … |
EVA ALMIRON-ROIG; | 2024-03-14 |
| 375 | A Double-blind, Randomized, Placebo-controlled, Multiple-dose, Parallel Group With Nested Crossover Design Trial With Moxifloxacin As Positive Control to Evaluate The Effects of Multiple Subcutaneous Doses of BI 456906 in A Titration Scheme on Cardiac Safety Parameters in (Otherwise) Healthy Male and Female Subjects With Overweight/Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults between 18 and 55 years of age with overweight or obesity. The purpose of this study is to find out whether a medicine called survodutide (BI 456906) has an effect on cardiac safety. When a new medicine is developed, it is important to check whether it affects the heart. Moxifloxacin is a medicine that is known to change the heart rhythm. In this study, … |
BOEHRINGER INGELHEIM | 2024-03-13 |
| 376 | Ultrasound-guided Erector Spinae Plane Block Versus Transversus Abdominis Plane Block for Pain Control After Cesarean Section in Obese and Morbidly Obese Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present stratified randomized study aimed to compare the analgesic efficacy and safety profile of ESPB and TAPB used for postoperative pain management in obese and morbidly obese women undergoing CS. |
WARDA DEMERDASH KHALIFA ALI; | 2024-03-10 |
| 377 | The Effects of Psychosocial Factors in Physical Activity Promotion Among Overweight and Obese Children in Yunnan Province, China Using Youth Physical Activity Promotion Model PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to evaluate the effectiveness of an intervention program based on the Youth Physical Activity Promotion Model (YPAP) in increasing physical activity levels among overweight and obese children in China. |
HAN MINGXUE; | 2024-03-10 |
| 378 | A Study of RM-718 Weekly Formulation in Healthy Subjects With Obesity and in Patients With Hypothalamic Obesity (HO) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with hypothalamic obesity (HO). |
RHYTHM PHARMACEUTICALS | 2024-03-05 |
| 379 | Gut Microbiota Profile Analysis and Randomized Controlled Trials (RCT) Study of The Effect of Synbiotics on Insulin and TNF-α in Metabolic Dysfunction -Associated Fatty Liver Disease (MAFLD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Objective: To analyze the effect of synbiotic supplementation on metabolic profile, insulin and TNF-α and gut microbiota changes in patients with Metabolic dysfunction-Associated Fatty Liver Disease (MAFLD). Research question: Are there any changes in metabolic profile, Insulin and TNF-α and gut microbiota changes in MAFLD patients after synbiotic supplementation Participants will: – Treatment group given supplementation and the control group will be given placebo at a dose of 2×1 tablet for 12 weeks. – Patients will visit the hospital every 28 days for up to 4 months for control and follow-up supplementation. – … |
ADRIYAN PRAMONO; | 2024-03-04 |
| 380 | Does Deciding Not to Participate in A Lifestyle Intervention Affect The Long-term Change in Psychosocial Well-being for Children With Obesity? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood obesity has been associated with an increased risk of impaired psychosocial well-being and the development of depression and anxiety. However, little is known about the long-term psychosocial impact on children with obesity who decided not to participate in lifestyle interventions, representing a critical gap in literature. This study includes approximately 400 children with obesity aged 5-10 years living in Aarhus municipality in the time-period 2014-2020, who either decided not to participate in a lifestyle intervention, … |
UNIVERSITY OF AARHUS | 2024-03-01 |
| 381 | A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of RGT001-075 Compared With Placebo in Adult Patients With Obesity or Overweight PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being conducted to evaluate RGT001-075 to help people who are above a healthy weight range to lose weight. In this study participants will either get RGT001-075 or a dummy medicine (placebo). Which treatment participants get is decided by chance. Participants need to take RGT001-075 or placebo once every day for 12 weeks. |
REGOR PHARMACEUTICALS | 2024-03-01 |
| 382 | Effectiveness of Two Different Body Positions During Facemask Ventilation in Class 3 Obesity Patients: A Randomized Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is important to provide enough oxygen to the patients who are asleep during surgery. One way to do this is by using a mask placed over the face to help them breathe. When it becomes difficult getting enough oxygen into the patient’s body using the mask, it’s called difficult mask ventilation. There can be different reasons for this, … |
FABRICIO ZASSO; | 2024-03-01 |
| 383 | The Effect of Turnip Consumption and Qigong Exercise Program on Weight Loss Among Female Students: Clinical Trail PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity and weight-related issues are prevalent concerns affecting individuals worldwide, with particular significance among the younger demographic, such as female students. As lifestyles evolve and dietary habits play a pivotal role in overall well-being, exploring innovative approaches to weight management becomes imperative. Thus, obesity is a huge public health importance with economic emotional and social consequences. |
SAFAA RABEA OSMAN; | 2024-03-01 |
| 384 | The Effect of Laparoscopic Sleeve Gastrectomy on The Change in Carotid Intima-media Thickness in Patients With Obesity: Prospective Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to compare carotid intima-media thicknesses in laparoscopic sleeve gastrectomy patients preoperatively and at the end of the first postoperative year. |
MUHAMMED TAHA DEMIRPOLAT; | 2024-03-01 |
| 385 | Effects of Aerobic Exercise on Kinesiophobia, Functional Capacity and Quality of Life in Obese Patients With Atherosclerotic Cardiovascular Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is classified using body mass index (BMI) (BMI ≥25 overweight, BMI ≥30 obese, BMI ≥40 morbidly obese). Obese patients are Class 1 according to BMI; BMI:30-34.9 and Class 2; BMI: It is classified as 35-39.9. Patients with classes 1 and 2 will be included in the study. Obesity can be accompanied by comorbidities such as atherosclerotic vascular and cardiac pathologies, hyperlipidemia, hypertension, coronary artery disease, diabetes mellitus, so obesity treatment should be managed multidisciplinary. The basic approach to obesity treatment is diet, exercise, medical treatment, treatment of comorbid conditions and surgery. Aerobic exercise therapy, … |
HAVVA TALAY ÇALIŞ; | 2024-03-01 |
| 386 | Effects of Time-restricted Eating Combined With Aerobic Exercise Training on Body Composition and Cardiometabolic Parameters in Women With Overweight and Obesity: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Time-restricted eating (TRE) is a dietary approach that aims to increase fasting time and decrease the eating window. Promising TRE effects on weight loss and improvements in some cardiometabolic risk factors have been reported in studies in animals and humans. However, the impacts of TRE combined with aerobic exercise training in individuals with overweight and obesity have been insufficiently investigated. Additionally, … |
ALVARO REISCHAK-OLIVEIRA; | 2024-03-01 |
| 387 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy, Safety, and Tolerability of GLY-200 in Participants With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the efficacy, safety, and tolerability of GLY-200 in participants with obesity. |
SUREKA BOLLEPALLI; | 2024-03-01 |
| 388 | Examining The Effect of Role-playing Exercise By Utilizing An Obesity Suit in A Simulation Scenario on Weight Bias and Empathy Levels Among Nutrition Sciences Students PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A quasi-experimental design (i.e., One-Group Pretest-Posttest Design) will be applied among 40 convenient samples of undergraduate students in their first year of nutrition sciences program at Ariel University and Tel-Hai College. The intervention will take place at the simulation centers of the institutions. All participants will be asked to wear an obesity simulation suit (Unisex obesity Simulation suit, Erler-Zimmer, … |
SHIRI SHERF DAGAN; | 2024-03-01 |
| 389 | An Open-label, One-sequence Cross-over, Single-centre Trial, Investigating The Influence of CagriSema on Pharmacokinetics and Pharmacodynamics of Warfarin and Pharmacokinetics of Atorvastatin in Participants With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at how CagriSema affects the blood levels of atorvastatin and warfarin. The study will look at the levels of warfarin and atorvastatin in the blood before the participant starts taking CagriSema and if this changes after the participant has taken CagriSema. The study will also investigate the effect of warfarin before and after the participant takes CagriSema and assess if the injection site affects the level of CagriSema in the blood. The study will last for about 8 months. |
NOVO NORDISK | 2024-02-27 |
| 390 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 2 Study Evaluating The Safety, Tolerability, and Efficacy of RAY1225 in Participants With Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to learn more about the Tolerability of RAY1225 in participants with Obesity. The study will also explore the efficacy of RAY1225. The study will last about six months for each participant. |
GUANGDONG RAYNOVENT BIOTECH | 2024-02-21 |
| 391 | Prelimenary Observational Study of The Influence of Adherence to The Recommandations Issued By The National Nutrition and Health Program on The Risk of Overweiht and Obesity in Children : The Case of A Municipality That Has Signed The Ville Active PNNS Charter PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood obesity has been rising steadily over the past 40 years. In 2016, the World Health Organization (WHO) observed around 340 million overweight or obese children and adolescents worldwide, including one in five in France. The causes are complex, both individual (genetic, biological, behavioral) and collective (social, economic, cultural). Childhood obesity encourages the development of chronic diseases such as diabetes and hypertension, and can affect mental health. Without early treatment, the risk of obesity persisting into adulthood is high. In the Alpes-Maritimes region, … |
KEVIN LEGUEULT; | 2024-02-20 |
| 392 | Assessment of Therapeutic Potential of Stigma Maydis (Cornsilk) on Metabolic Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Over the past two decades, there has been an increase in the number of people with nutrition related maladies due to changes in their dietary habits and lifestyle. Cardiovascular disease, type 2 diabetes, metabolic syndrome, obesity, and cancer have emerged as prominent contributors to both illness and death, particularly as the population continues to age. The mortality figures for cardiovascular disease and diabetes varied between 179.8 to 765.2 per 100,000 individuals, with the most elevated rates observed in poor nations. The occurrence of metabolic syndrome was markedly prevalent, … |
M. ASIF ALI; | 2024-02-20 |
| 393 | A Phase 1, Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled Study to Assess The Safety, Tolerability, and Pharmacokinetics of Multiple Escalating Oral Doses of PF-06954522 in Adult Participants With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple escalating oral doses of PF-06954522 in adult participants with inadequately controlled type 2 diabetes mellitus (T2DM) on metformin (Part A) and optionally in non-diabetic participants with obesity (Part B). |
PFIZER | 2024-02-20 |
| 394 | Feasibility of A Physical Activity Program in Patients With Metastatic Breast Cancer and Overweight: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test a physical activity program in patients with metastatic breast cancer and overweight receiving endocrine-based treatment. The aim of the study is to assess the feasibility and metabolic efficacy of a 12-week physical activity program in this patient group. The hypothesis is that improving metabolic health through physical activity can optimize cancer care. Participants will randomized 2:1 to either a physical activity program or care as usual. |
SIGNE BORGQUIST; | 2024-02-19 |
| 395 | Effect of Low-Volume High-Intensity Training Vs. Moderate Intensity Continuous Exercise on Rate Pressure Product and Functional Capacity in Individuals With Increased BMI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the effect of low volume high intensity training and moderate intensity continuous exercise on Rate Pressure Product (RPP) and functional capacity. Limited literature available on effectiveness of Low-volume HIIT in comparison of other Aerobic interventions in obese individuals. In our community, people are sedentary and not involved in routine exercise because of increased weight, so Low volume HIIT would be safe and convenient for such individuals to perform. There is also limited studies available on female gender so both genders are included in this study. |
MEHWISH WASEEM; | 2024-02-15 |
| 396 | The Effect of Mobile Application Supported Health Promotion Program on Obesity, Physical Activity and Stress Levels of Adolescents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate the effectiveness of the Child Obesity Program (COP), which is a school-based, parent-based, weight management program aimed mobile application at preventing overweight and obesity in childhood. |
CUMALI YILDIZDAL; | 2024-02-14 |
| 397 | Creation of Side-to-Side Compression Anastomosis Using The GT Metabolic Solutions DI Biofragmentable Magnetic Anastomosis System (Magnet System, DI Biofragmentable) to Achieve Jejuno-Ileal Diversion in Adults With Obesity and Type 2 Diabetes Mellitus: MJI Study Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical research study is to evaluate the feasibility/performance, safety and initial efficacy of the GT Metabolic Solutions DI Biofragmentable Magnetic Anastomosis System (Magnet System, DI Biofragmentable and hereafter referred to as the DI Magnet System) for creation of a side-to-side jejuno-ileal anastomosis in adults with obesity and type 2 diabetes mellitus (T2DM). |
GT METABOLIC SOLUTIONS | 2024-02-13 |
| 398 | Lifestyle Intervention With Physical Activity and Diet for Precision Health in Individuals With Overweight: A 6-month Pilot Randomized Controlled Trial (LI-PAD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this pilot randomized controlled trial LI-PAD is to identify whether a 6-month intervention approach to individually optimize lifestyle behavior, physical activity, and diet, is feasible and leads to larger improvements in body weight, cardiovascular disease risk factors, and health-related quality of life compared to simple written lifestyle advice, in individuals with overweight or obesity. The intervention group will be offered individual support for lifestyle behavioral change (precision health) and the control group will be offered written lifestyle advice, following national recommendations. In total, 60 population-based participants and 60 controls from the Gothenburg area, aged 45-65 years, … |
MATS BÖRJESSON; | 2024-02-12 |
| 399 | Reprogramming Energy Homeostasis in Overweight Children and Adults Trough Exercise, Cognitive Training and Social Interaction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The RESILIENT project is a clinical trial investigating leptin sensitivity in both children and adults with overweight or obesity. The study examines the additive effects of Cognitive Training (CT) and Social Training (ST) on leptin sensitivity, compared to stand-alone Intensive Health Behaviour Treatment (IHBT), which includes diet and Physical Activity (PA). The intervention will last for 8 weeks, followed by a 12-week washout period. A multilevel assessment will be conducted, … |
MELANIA MANCO; | 2024-02-08 |
| 400 | A Phase 2, Parallel-Group, Double-Blind Study to Investigate Weight Management With LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate weight management efficacy and safety with LY3841136 compared with placebo in adult participants with obesity or overweight. The study will last about 64 weeks and may include up to 17 visits. |
ELI LILLY | 2024-02-05 |
| 401 | Design and Integration of A Survivorship Nutrition Intervention Into An Established Exercise Oncology Program: The BfedBwell Pilot Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This single-arm proof-of-concept pilot will assess the feasibility and acceptability of integrating a survivorship nutrition intervention (BfedBwell) into an existing clinical exercise oncology program (BfitBwell). |
EMILY B HILL; | 2024-02-05 |
| 402 | Effects of Antagonizing The Ghrelin Receptor on Total-body Glucose Metabolism in Obesity Related Papers Related Patents Related Grants Related Experts View Highlight: The naturally occurring hormone LEAP2 is proposed to have opposite effects to that of the ‘hunger hormone’ ghrelin. Other that appetite regulation, LEAP2 is involved in glucose metabolism through mechanisms yet not fully understood. With two experimental days; one recieving LEAP2 and one recieving placebo infusion in a randomized order, the study will explore the effect of LEAP2 (vs. placebo) on glucose metabolism through total-body PET/CT-scans and thereby gain a deeper understanding of the ghrelin/LEAP2 system and its interaction with glucose metabolism. Furthermore, the project will generate scanning references in individuals with obesity that are usable in forthcoming research projects. |
FILIP KRAG KNOP; | 2024-02-05 |
| 403 | The Effect of A Machine Learning-Based Mobile Application on Physical Activity in Overweight and Obese Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effect of an algorithm-driven mobile application that provides personalized recommendations for increasing physical activity, which is an important health behavior, in the prevention of obesity and many other related non-communicable diseases in overweight and obese women. Hypotheses of this study are: – The physical activity level of overweight and obese adult women in the intervention group increases. – Body Mass Index decreases in overweight and obese adult women in the intervention group. – … |
EZGI HASRET KOZAN CIKIRIKCI; | 2024-02-04 |
| 404 | Role of Insulin Action in Psoriasis Pathogenesis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to collect more information from people with plaque psoriasis and to determine if insulin plays a role in the pathogenesis of psoriasis. The main question it aims to answer is if insulin action is preserved or even enhanced in psoriatic lesions despite insulin resistance elsewhere. Participants with plaque psoriasis will have punch biopsies taken of lesional and non-lesional skin after an overnight fast and then during an oral glucose tolerance test. Biopsy specimens will then be assessed for markers of insulin action. |
JOSHUA COOK; | 2024-02-02 |
| 405 | Shift-and-persist and Cardiometabolic Markers Among Women in Puerto Rico: A Pilot of A Mindfulness-based Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the feasibility and acceptability of a 4-week mindfulness program among young women in Puerto Rico with elevated stress. The main questions it aims to answer are: – how feasible and acceptable is a s a 4-week mindfulness program among participants with elevated stress – what are the changes in psychological resilience, psychological distress, health behaviors, and cardiometabolic markers Participants will be asked to – attend 4 weekly virtual sessions and daily mindfulness exercises at home – complete online study questionnaires |
ANDREA LOPEZ-CEPERO; | 2024-02-02 |
| 406 | The Microbiome As A Modifiable and Predictive Factor in Obesity Treatment: Impact of Nutritional Intervention With Probiotics and Prebiotics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is one of the most severe and prevalent non-communicable diseases worldwide, affecting an estimated one-third of the population in Spain. It is a multifactorial disease that, in extreme cases such as morbid obesity, can become highly disabling and is associated with significant morbidity and mortality. This is because it serves as a risk factor for numerous chronic diseases, including metabolic conditions (type 2 diabetes mellitus), cardiovascular diseases (hypertension, atherosclerosis, etc.), and even cancer. The exact etiopathogenic mechanisms are not fully understood, but subclinical inflammation is considered to form the basis of the metabolic (diabetes) and cardiovascular (endothelial dysfunction, dyslipidemia, … |
ALBA RODRIGUEZ NOGALES; | 2024-02-01 |
| 407 | A Multicenter, Randomized, Double-blinded, Placebo-controlled, Parallel-group Phase ⅡStudy to Evaluate The Efficacy and Safety of HRS-7535 in Obese Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this trial is to evaluate the efficacy and safety of HRS-7535 in Chinese Obese Subjects. |
SHANDONG SUNCADIA MEDICINE | 2024-02-01 |
| 408 | Slow Gait Speed As An Indicator of Overweight, Dynapenic Obesity and Sarcopenic Obesity in Elderly People in The Community PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate the relationship of gait speed with dynapenic or sarcopenic obesity in community-dwelling older people. The main questions it aims to answer are: – Is slow walking speed related to overweight in older people in the community? – Is slow walking speed related to dynapenic obesity in older people in the community? – Is gait speed related to sarcopenic obesity in older people in the community? Participants will answer a clinical interview to obtain sociodemographic data and will perform the following clinical tests: (1) 10-meter walk test, (2) Anthropometric measurement; … |
KAREN CÓRDOVA-LEÓN; | 2024-02-01 |
| 409 | A Randomised, Double-blinded, Placebo- Controlled, Parallel Study, to Assess The Effect of A Whole Fruit Powder on Gut Microbiome Function on Overweight & Obese Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effect of freeze-dried blueberry powder on the gut microbiome in overweight and obese adults. The main question[s] it aims to answer are: – Does the supplementation of freeze-dried blueberry powder reduce the risk of obesity or lower the weight of people with a high BMI? – Does freeze-dried blueberry powder alter the gut microbiome function? Participants will; – Mix one sachet of Study Product (freeze-dried blueberry powder/placebo) into breakfast/dessert/yoghurt daily for 56 days during the intervention phase. – Partake in 4 site visits over the 14-week period, … |
TIMOTHY DINAN; | 2024-02-01 |
| 410 | The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the effect of glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on disordered eating behaviour in patients with overweight and type 2 diabetes. The investigators will also evaluate serum concentrations of incretin hormones GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), as well as glucose variability using continuous glucose monitoring (CGM) devices before and after semaglutide, … |
JELENA MARINKOVIC RADOSEVIC; | 2024-02-01 |
| 411 | Environmentally Sustainable Nutrition for Older Adults (55+) With Obesity: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the pilot study (feasibility study) is to assess the acceptability and feasibility of the developed 2EAT dietary treatment in obese older adults (55+). For ecological reasons, the goal of the dietary treatment plan is to achieve an intake of 60% plant-based proteins in older adults (55+) in a healthy and nutritionally adequate way during a period of weight loss. The investigators developed the new dietary treatment plan for 6 months (RCT). To further optimize the new treatment plan the 2EAT study includes this feasibility study with a duration of 8 weeks. In the feasibility study, … |
PETER WEIJS; | 2024-02-01 |
| 412 | Antiemetic Effect of Acupressure Wristbands for GLP-1RA Related Nausea PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Nausea is a common side effect of GLP-1RA medications used for treatment of Type 2 diabetes mellitus and obesity. Current recommendations for nausea relief include the use of dietary changes and prescription anti-emetics. Acupressure wristbands Sea-Band are FDA cleared for nausea relief in other indications such as motion sickness, morning sickness in pregnancy, post-operative nausea, chemotherapy associated nausea. We hypothesized that acupressure wristbands could alleviate nausea in persons taking GLP-1RA. |
FLORENCIA ZIEMKE; | 2024-02-01 |
| 413 | Does A Virtual Coach Offer A Better Solution for Weight Reduction in Ventral Hernia Patients With Obesity? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose for this research is to create a MyChart-enabled virtual coach that assists obese patients lose weight prior to ventral hernia surgery. Researchers intend to show how the use of a virtual coach is more effective in preoperative weight reduction prior to ventral hernia repair over usual care. Correspondingly, this may lower unplanned hospital readmissions. For this clinical trial, where randomization is not possible, … |
JANA SACCO; | 2024-02-01 |
| 414 | Digital-Physical Family Intervention in Primary Care for Families With Obesity in Both Children and Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity in childhood is a global public health problem which continues to increase. It is associated with type 2 diabetes, high blood pressure, certain types of cancer, decreased psycho-social health and early mortality, among many other short- and long-term consequences. In many families where a child has obesity, at least one parent also has obesity or overweight with co-morbidity. In many cases, the care for children is more structured than for adults. Family treatment aimed at making lifestyle changes for the entire family, with those with obesity also restricting their calorie intake to normalize weight, … |
PERNILLA DANIELSSON; | 2024-02-01 |
| 415 | Dietary Intake Status and Time-Restricted Feeding on Cardiovascular Health Effects in The Overweight Population: A Study of Students at A Shenzhen University PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study Design and Participants This intervention study was conducted as a randomized controlled trial (RCT) aimed at investigating the effects of time-restricted feeding (TRF) on cardiovascular health markers among overweight male university students in Shenzhen, China. The study recruited male university students aged between 18 and 24 years, with a Body Mass Index (BMI) ranging from 24 to less than 28. All participants were free from severe psychiatric illnesses, metabolic syndrome, diabetes, alcoholic fatty liver disease, hyperthyroidism, or hypothyroidism. Inclusion criteria required participants to be non-smokers, not currently on any diet pills, … |
ZHENGQI QIU; | 2024-02-01 |
| 416 | Effect of Iso-alpha Acids and Xanthohumol on The Human Immune System in Overweight People With The Onset of Metabolic Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present study is to determine the effect of Iso-alpha Acids and Xanthohumol from hops on the immune response in overweight participants. |
INA BERGHEIM; | 2024-02-01 |
| 417 | Promoting Positive Mental Health for Sustainable Eating Behaviors: The PROMISE Study in Patients With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the present study is to assess the effects and the effectiveness of a psychological intervention based on the principles of well-being therapy (WBT) in promoting weight-loss, sustainable and healthy eating behaviors and an optimal psychological functioning in patients with obesity. |
ELENA TOMBA; | 2024-01-30 |
| 418 | Comparison of Coping Strategies to Reduce Food Cravings During Dietary Weight Loss PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose is to optimize the EMPOWER program by integrating strategies to reduce food cravings, a critical yet often overlooked factor for long-term success in weight management. The objective of this study is to determine the efficacy of craving coping strategies on weight loss outcomes by conducting a randomized controlled trial. Participants will be randomized to receive one of the two strategies to manage food cravings. |
MANABU NAKAMURA; | 2024-01-29 |
| 419 | Physics Informed Machine Learning-based Prediction and Reversion of Impaired Fasting Glucose Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this prospective, non-randomized, monocentric study, data will be collected from otherwise healthy individuals with overweight/obese grade I to increase data availability in the pre-diabetes field (impaired glucose intolerance), and to validate the outputs of an algorithm for the physics-informed machine learning (PIML) designed to estimate the real-time risk of prediabetes. Each participant will take part in the study for 4 months, including 3 onsite visits. During the screening visit, … |
JELIZAVETA SOKOLOVSKA; | 2024-01-29 |
| 420 | Whole Genetic Approach in Early Genetic Identification of Obesity (WEGIO) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl. participants clinically diagnosed with Bardet-Biedl-Syndrome (BBS) NUMBER OF PARTICIPANTS: 1000 for initial genetic sequencing and app. 40 for the follow-up documentation COORDINATING INVESTIGATOR: Prof. Dr. Arndt Rolfs |
ROLFS CONSULTING UND VERWALTUNGS GMBH RCV | 2024-01-24 |
| 421 | A Randomized, Double-blind, Placebo-controlled Phase 2 Study of TG103 Injection in The Management of Non-diabetic Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, double-blind, placebo-controlled, parallel phase 2 study to evaluate efficacy, safety, pharmacokinetic characteristics and immunogenicity of TG103 injection for weight management in non-diabetic patients with overweight in the presence of comorbidities or obesity, in addition to lifestyle intervention. |
CSPC BAIKE SHANDONG BIOPHARMACEUTICAL | 2024-01-20 |
| 422 | Examining The Impact of Different Types of Front-of-package Warning Labels for Sugar-sweetened Beverages on Perceived Weight Stigmatization Among A Sample of US Adults PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this experiment is to examine the effects of three different types of front-of-package warning labels for sugar-sweetened beverages on perceived weight stigmatization, as well as the effect of making such labels more weight-neutral. The main questions this experiment aims to answer are: – Are certain types of front-of-package warning labels perceived as more stigmatizing than others? – Are more weight-neutral versions of front-of-package warning labels perceived as less stigmatizing than their regular versions? – Is there a trade-off between label effectiveness in discouraging product consumption and perceived weight stigmatization? Additionally, … |
ALINE D’ANGELO CAMPOS; | 2024-01-15 |
| 423 | The Relationship Between Sociodemographic Characteristics, Lifestyle, and Diet Quality With Diabetes Risk in Overweight and Obese Adults PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the relationship between diabetes risk with sociodemographic characteristics, lifestyle and diet quality in overweight and obese individuals. The main question it aims to answer is: Is there a relationship between diabetes risk and diet quality in overweight and obese individuals? Participants who are overweight and obese will answer survey questions about sociodemographic characteristics and lifestyle behaviors. 24 hour dietary recalls will be taken to evaluate diet quality. FINDRISC questionnaire will be applied to assess diabetes risk. |
RAHIME EVRA KARAKAYA; | 2024-01-15 |
| 424 | Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation &Amp;Amp;Amp;Amp; Metabolic Rate PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: At least 30% of Americans have fatty liver disease. This means that they store too much fat in the liver. At the moment lifestyle changes are the only way to treat this problem. Objective: To test how (1) a low-carbohydrate diet and (2) a supplement called nicotinamide riboside (NR) affect how a person s body uses dietary fat. Eligibility: Men aged 18 to 65 and women aged 18 to 50 who are healthy volunteers with a body mass index (height to weight ratio) of 25 or more. Adults with maturity-onset diabetes of the young type 2 (MODY2) are also needed. Design: Participants with diabetes will have 1 screening visit and a 9-day clinic stay. Healthy volunteers will have 1 screening visit and 2 clinic stays of 1 to 2 weeks each. During screening, all participants will have a physical exam with blood and urine tests. They will have their heart rhythm measured while riding a gym bike. NR is a pill taken by mouth. Only healthy volunteers will take the NR, for 14 days at a time, during 1 clinic stay. During their other stay, they will take placebos; these are pills that look like the study supplement but contain no NR. During each clinic stay, all participants will eat a normal American diet. Then they will eat a ketogenic low-carb diet for 5 days. Participants will have many tests, including: Sleeping every night and having two 24-hour stays in a special room that measures the gases their body uses and produces. Drinking a high-fat shake, then remaining seated for 5 hours while their blood and breath are monitored. Having a substance injected into the arm and remaining seated for 3 hours while their blood is measured. Wearing monitors to measure their activity levels. Another monitor will measure their blood glucose levels. Having imaging scans. … |
STEPHANIE T CHUNG; | 2024-01-08 |
| 425 | Effect of Weight Loss on Hepcidin Levels and Iron Status in Subjects With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity and iron deficiency are the nutritional disorders with the highest prevalence worldwide. Different mechanisms have been proposed to explain iron deficiency secondary to obesity. Among the most studied is the deficit in dietary iron intake or the increase in blood volume that increases the need for the metal. However, one of the most plausible mechanisms linking obesity and iron deficiency is low-grade systemic inflammation, … |
MARTHA GUEVARA CRUZ; | 2024-01-08 |
| 426 | Anti-obesity Effects of Dandelion (Taraxacum Officinale L.) in Premenopausal Obese Women: Impacts on Appetite, Energy Intake and Lipid Metabolism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study investigates the effectiveness of the natural product Dandelion in treating obesity in premenopausal women through a randomized interventional trial, measuring various parameters and biomarkers. |
RABAB AHMED MOHAMED; | 2024-01-05 |
| 427 | Effect of Triticum Aestivum on Appetite Regulation and The Ghrelin, Leptin, Adiponectin Hormonal Axis in Patients With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity represents one of the major health problems worldwide; it is clear that current approaches to address obesity are largely unsuccessful. The endocrine axis of leptin and ghrelin acts as the critical link between adipose tissue and hypothalamic centers that regulate food intake, satiety, energy expenditure and weight. Despite being a highly prevalent disease with major complications, current therapeutic options are not sufficient, … |
SANDRA O HERNANDEZ GONZALEZ; | 2024-01-03 |
| 428 | Sleep Extension or Regularity to Reduce Diabetes Risk in African American and Black Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to identify an intervention that improves sleep health and consequently metabolic health by examining whether sleep extension or enforced regularity in short sleepers will have beneficial effects on diabetes and obesity risk. |
ERIN HANLON; | 2024-01-03 |
| 429 | A Drug-Drug Interaction Study to Assess The Effect of Orforglipron on The Pharmacokinetics of Digoxin, Simvastatin, Rosuvastatin, Acetaminophen, and Midazolam in Healthy Overweight and Obese Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine effect of orforglipron capsule formulation on the amount of digoxin, rosuvastatin, acetaminophen, midazolam, and simvastatin (given together and separately) that enters the bloodstream and how long it takes the body to eliminate them when administered orally in healthy overweight and obese participants. In addition, … |
KATHLEEN DOISY; | 2024-01-02 |
| 430 | Effect of A Glucagon Like Peptide 1 (GLP1) Booster on Blood Glucose, HbA1c, Insulin, and GLP1 Levels, Body Weight and Body Fat in Overweight Adult Men and Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND GLP1 booster (GB) was designed to stimulate the endogenous production of GLP1, which in turn releases insulin, controls blood glucose level, suppresses appetite and thus helps people lose weight. PURPOSE The purpose of this study is to assess several clinical endpoints and questionnaires in healthy volunteers taking the new GB formula. SCOPE The scope of this protocol covers the non-clinical portion as well as the assessment of several clinical endpoints and questionnaires. In brief, … |
LAWRY HAN; | 2024-01-02 |
| 431 | Impact of Multifactorial Lifestyle Interventions on Psychosocial Well-being for Children Living With Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood obesity has been associated with an increased risk of impaired psychosocial well-being and the development of depression and anxiety. This study includes approximately 200 children with obesity aged 5-10 treated within one of two multifactorial family-centered lifestyle intervention in the time-period 2014-2020. Additionally, this study includes 150 children with obesity in the same age group, … |
UNIVERSITY OF AARHUS | 2024-01-01 |
| 432 | Promotion of Daily Recommended Physical Activity for Adolescents’ Health Through Mobile Apps, Wearables, and A Gamified TAC PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A primary factor in preventing diseases in adulthood, as well as overweight and obesity, is the promotion of physical activity from childhood and adolescence. Although the recommendations for practicing physical activity at this stage are broad, low rates of practice that do not comply with the recommendations are reported. There is a high percentage of use of new technologies, particularly mobile applications, they have been used with some success to improve the health of similar populations, although its use for this purpose has certain limitations. Therefore, … |
RAQUEL VAQUERO-CRISTÓBAL; | 2024-01-01 |
| 433 | Prevalence of and Risk Factors of Obesity in School Children and Adolescents in Nag Hammadi City PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Searching for obese children who’s body mass index is above normal range and risk factors in children and adolescents in Nag Hammadi city |
DOAA HAGOUG AHMED; | 2024-01-01 |
| 434 | Comparison of Physical Activity, Functional Capacity and Quality of Life Between Older Patients With Chronic Comorbidities and Healthy Peers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The prevalence of obesity, hypertension (HT) and type 2 diabetes (T2D) is increasing. The adoption of an increasingly sedentary lifestyle is one of the main factors contributing to the increased incidence of chronic diseases such as obesity, cardiovascular diseases, HT and T2D. Furthermore, lack of physical activity leads to a decline in functional capacity in these individuals, which facilitates the progression of HTN, T2D and obesity. The presence of multiple chronic comorbidities can exacerbate the negative impact on health-related quality of life. The main aim of this study was to compare the levels of physical activity, … |
HIKMET UCGUN; | 2024-01-01 |
| 435 | Effects of Individualized Positive End-expiratory Pressure Guided By Driving Pressure on Postoperative Atelectasis After Bariatric Surgery in Patients With Morbid Obesity: A Single-center, Prospective, Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Atelectasis is a common complication in patients undergoing surgery under general anesthesia, particularly in obese patients. Postoperative atelectasis could last for more than 24h and contribute to a variety of other complications, including hypoxemia and pneumonia. We plan to conduct a single-center, randomized controlled trial in patients undergoing bariatric surgery to test the hypothesis that driving pressure guided PEEP could reduce the postoperative atelectasis. |
YONGTAO SUN; | 2024-01-01 |
| 436 | EAT: A Reliable Eating Assessment Technology for Free-living Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study utilizes a small, privacy-conscious wearable device intended to monitor human behaviors. The device is worn around the neck, capturing the wearer’s head and upper torso within its field of view, and records color images without audio. Participants visit the lab for consent, device training and recording of several activities using the device. Participants will then take the device home and wear it during their normal schedules for four active weeks. During each active week, participants will wear the device, … |
NABIL ALSHURAFA; | 2024-01-01 |
| 437 | The Role of Oxytocin-receptor Signalling in Physiological Regulation of Eating Behaviour in Individuals with Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study evaluates appetite, glucose metabolism, gastrointestinal motility and energy expenditure in men and women with obesity (BMI 30-40 kg/m2) under oxytocin exposure compared to placebo. |
FILIP KRAG KNOP; | 2024-01-01 |
| 438 | Effects of Lifestyle Changes on Tinnitus in Older Adults With Metabolic Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The problem of tinnitus (subjective type) is prevalent in obese older adults with different diseases such as metabolic syndrome. The changes of lifestyle are very important to lose weight, improve tinnitus and metabolic syndrome |
ALI MOHAMED ALI ISMAIL; | 2024-01-01 |
| 439 | Gut Microbiome Dyspiosis in Colorectal Cancer Egyptian Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Colorectal cancer (CRC) is reported to be the third leading cause of cancer deaths worldwide, and its prevalence is steadily rising in developing countries. It can be considered a marker of socioeconomic development and a marker of significant changes in food habits and lifestyle. In Egypt, CRC represents the seventh most common cancer. It is the third most reported cancer in males and the fifth most common cancer in females. microbiome dysbiosis may be involved in the pathogensis and thus pose a therapeutic target |
SARA MOSTAFA ELADAWY; | 2024-01-01 |
| 440 | Another Look to Exercise Prescription: Exercise Timing and The Circadian Clock in Individuals With Type 2 Diabetes and Those at Risk PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many investigations have been done to determine the exercise that can elicit the greatest benefits on glycemic control and metabolic health, with findings suggesting that incorporation of higher intensity and longer duration of exercise prescribed may eliminate much of the non-response observed following exercise training. Even with the incorporation of higher intensity exercise into interventions aimed at improving glycemic control in individuals with type 2 diabetes mellitus (T2DM), the investigators and others continue to have mixed results, … |
JOÃO B MAGALHÃES; | 2024-01-01 |
| 441 | Investigation of The Effect of Progressive Relaxation Exercises on Anxiety and Pain Level in Patients Undergoing Obesity Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to find out whether progressive relaxation exercises work on the effect of anxiety and pain level in patients undergoing obesity surgery. The main questions that it aims to answer are: – Do progressive relaxation exercises reduce participants’ pain levels? – Do progressive relaxation exercises reduce participants’ anxiety levels? The researchers will compare the effect of progressive relaxation exercises on the level of anxiety and pain between experimental and control groups . Participants: – … |
ŞUHEDA ZORER; | 2024-01-01 |
| 442 | Testing The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function in Older Adults Living With Overweight or Obesity: A 28-Day Pilot Randomised Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot study will compare the effect of combining dietary nitrate and caloric restriction versus dietary nitrate alone. The participant will be contacted, having responded to an advertisement on social media and posters, to attend the screening visit. They will be asked about their health status, suitability for MRI and availability. The investigators will use physical activity and eating attitude questionnaires. The investigators will also measure their height, weight, body mass index (BMI), and blood pressure (BP) and undertake blood tests. If they are eligible, … |
MOIRA TAYLOR; | 2024-01-01 |
| 443 | Addressing Root Causes of Under-hydration in School: A Stakeholder Collaborative Pilot Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will pilot a school-based stakeholder-informed hydration intervention and examine its feasibility and preliminary efficacy. |
MELANIE BEAN; | 2023-12-30 |
| 444 | Empagliflozin in CFRD: Efficacy and Safety of SGLT2 Inhibitor Therapy in Overweight and Obese Subjects with Cystic Fibrosis-related Diabetes: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This will be a placebo-controlled, randomized, double blind, crossover study with a 4 week wash out period. Collect pilot data on the safety, tolerability, and feasibility of empagliflozin therapy in overweight/obese patients with CFRD to support a future larger randomized controlled trial. |
AMIR MOHEET; | 2023-12-30 |
| 445 | A Multi-center, Randomized, Double-blind, Placebo-controlled Phase II Clinical Study to Evaluate The Efficacy and Safety of VCT220 Tablets in Overweight/obese Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to assess how VCT220 tablets affect the bodyweight when used once daily in obese or overweight adult participants Qualified participants will be randomly assigned to one of four groups using a computerized system. Participants will get VCT220 or placebo tablets for 16 weeks and will need to take tablets each morning. Participants will have 7 clinic visits and a final follow-up visit approximately 14 days after the last study intervention administration. |
VINCENTAGE PHARMA | 2023-12-27 |
| 446 | Prevalence and Economic Burden of Obesity-related Comorbidities in The Gulf Region: A Retrospective, Observational Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess the annual prevalence of ORCs among adult people with obesity in the real-world clinical setting across the Gulf region. In addition, the study will describe the annual HCRU and associated costs of obesity and ORCs, describe the demographics and clinical characteristics of adult people with obesity, as well as estimate the annual incidence and point prevalence of the ORCs among adult people with obesity. |
NOVO NORDISK | 2023-12-21 |
| 447 | A Non-randomised, Open-label Phase I Trial to Evaluate The Effect of BI 456906 at Different Dose Levels of Multiple Subcutaneous Doses in A Titration Scheme on The Single Dose Pharmacokinetics of A Combination of Ethinylestradiol and Levonorgestrel in Otherwise Healthy Women With Overweight/Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to women with overweight or obesity who are otherwise healthy. Women with a body mass index (BMI) from 27 to 40 kg/m2 can participate. The purpose of this study is to find out whether taking multiple doses of BI 456906 influences the amount of ethinylestradiol and levonorgestrel in the blood. Ethinylestradiol and levonorgestrel are ingredients of the contraceptive Microgynon®. The study has 2 treatment periods. In Period 1, participants get 1 tablet of Microgynon®. In Period 2, … |
BOEHRINGER INGELHEIM | 2023-12-21 |
| 448 | Validation of A Mindful Eating Program Adapted to The French Population Living With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this project is to validate a new mindful eating programme adapted to the overweight or obese French population. Recognising the importance of diet in the management of chronic diseases, particularly obesity, and the limitations of traditional weight management approaches, the study focuses on the application of mindful eating. The investigators have adapted a model based on an existing eating disorders programme overseas, … |
ANTOINE AVIGNON; | 2023-12-17 |
| 449 | Overweight, Obesity and Weight Variation Among Incarcerated Women in French Guiana: A Study of Factors Associated With Weight Gain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Overweight and obesity are a public health issue, given the morbi-mortality they entail: increase in chronic diseases such as cardiovascular disease, diabetes, musculoskeletal disorders, certain cancers. According to the 2019 European Health Survey, French Guiana has a high rate of overweight and obesity, affecting 51% of its population (compared with 47% in mainland France), with a higher prevalence among women (23%), this phenomenon being partly attributed to unfavorable eating habits and a sedentary lifestyle. Another study in French Guiana showed that 54.7% of those surveyed were overweight or obese, with a higher risk of obesity among single women, … |
CENTRE HOSPITALIER DE CAYENNE | 2023-12-14 |
| 450 | A Single-ascending and Multiple-ascending Dose Study of LY3971297 in Healthy Participants and Participants With Obesity and Hypertension and Participants With Decreased Estimated Glomerular Filtration Rate PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to measure side effects of LY3971297 injection administered under the skin in healthy participants and obese participants with high blood pressure (BP). Blood tests will be performed to check how much LY3971297 gets into the bloodstream and how long it takes the body to eliminate it. This is a 7-part study. The study duration will be approximately 60 days for Parts A and F, and approximately 90 days for Parts B, C, D, E, and G. |
AMINA HAGGAG; | 2023-12-07 |
| 451 | Time-Efficient Inspiratory Muscle Strength Training As A New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether inspiratory muscle strength training reduces blood pressure in adults with obesity. |
JOSEPH WATSO; | 2023-12-07 |
| 452 | A 42-Day Multiple Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-757 And K-833 in Overweight/Obese Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multiple dose study to evaluate the safety, tolerability, PK, and PD of K-757 and K-833 when co-administered in overweight/obese patients with Type 2 diabetes mellitus (T2DM) |
KALLYOPE | 2023-12-07 |
| 453 | Investigating The Effects of Pilates on Body Composition, Posture, and Psychosocial Parameters in Women with and Without Obesity: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity, a health problem, is caused by insufficient physical activity and unhealthy nutrition. For individuals with obesity, non-weight-bearing and enjoyable exercises, such as Pilates, should be implemented as physical activity due to potential pain. This study aims to examine the effects of an 8-week Pilates exercise program on body composition, posture, and psychosocial parameters in individuals with and without obesity. Methods: The study included 58 female participants: 30 individuals with obesity (nPilates = 15; nControl = 15) and 28 individuals without obesity (nPilates = 14; … |
SEMA ARSLAN KABASAKAL; | 2023-12-07 |
| 454 | Effect of Smart Phone Delivered Health Education Intervention on Overweight and Obese Schoolchildren’s Dietary Habits and Body Composition in The UAE PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effect of mobile health nutrition education intervention in the changing of dietary habits and body composition of overweight and obese 8-12 years old children in Sharjah, United Arab Emirates and to compare its effectiveness to paper educational intervention among the same age group. The main questions it aims to answer are: 1. Are there any significant changes in dietary habits, … |
HEBA MUSTAFAALSAAFIN; | 2023-12-01 |
| 455 | Effects of Oral Intake of BK329 on Body Fat Reduction in Adults With Overweight or Obesity: A Randomized, Double-blind, Placebo-controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to determine whether BK329 reduces body fat in adults with overweight or obesity and to assess its safety. The main questions are: – Does BK329 reduce body fat in participants? – What side effects occur when participants take BK329? |
SANG YEOUP LEE; | 2023-12-01 |
| 456 | EffectiVenEss of A Rehabilitation Treatment With Nordic Walking in ObEse or OveRweight Diabetic PatiEnts With Cardiovascular Disease. The VENERE Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Nordic Walking (NW) is a biomechanically correct walking technique that originated in Finland in the 1930s as an off-season training method for cross-country skiers. In the NW, the use of special sticks is combined with conventional walking: this involves a greater caloric expenditure, with an energy consumption higher by 20-30% compared to walking without sticks, and also toning of the upper part of the body, in particular triceps, shoulders and back, and the involvement of about 90% of the body’s muscles, while maintaining a reduced load on ligaments and joints (Baek \& Ha, … |
NUCCIA MORICI; | 2023-12-01 |
| 457 | Impact of Endoscopic Gastric Reduction of Ghrelin Receptors Rich Gastric Mucosa on Obesity and Metabolic Syndrome: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the stomach, the ghrelin-containing cells are more abundant in the fundus than in the pylorus originally termed X/A-like cells. These X/A-like cells account for approximately 20 % of the endocrine cell population in adult oxyntic glands. Ghrelin enhances the secretion of growth hormone, the stimulation of appetite and food intake, the modulation of gastric acid secretion & motility and the endocrine and exocrine pancreatic secretions. |
AMR SHAABAN HANAFY; | 2023-12-01 |
| 458 | The Effect of Exercise With AR Glasses on Metabolic Parameters and Anthropometric Measurements in Obese Adolescents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was planned as a randomized controlled experimental study to determine the effect of exercise with Augmented Reality Goggles (AR) on metabolic parameters and anthropometric measurement values in obese children aged 10-19 years. The study will be conducted with children diagnosed with obesity between the ages of 10-19 years who are followed up in the Pediatric Endocrinology Outpatient Clinic of Erciyes University Health Application and Research Center Fevzi Mercan-Mustafa Eraslan Children’s Hospital. According to the sample calculation, … |
HARUN ÖZBEY; | 2023-12-01 |
| 459 | A First-in-Human Study to Assess The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Subcutaneous Doses of GUB014295 in Lean to Overweight or Obese But Otherwise Healthy Men PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center, double-blind, randomized, placebo-controlled, single ascending subcutaneous dose study in lean to overweight or obese but otherwise healthy men. It is planned to enroll 4 cohorts of 8 subjects (Regimens A, B, C and D), with 2 additional optional cohorts of 8 subjects (Regimens E and F). Within each cohort, subjects will be randomized in a ratio of 6 active to 2 placebo. The primary objective is to assess the safety. Secondary objectives are to characterize the pharmacokinetics (PK) and to investigate pharmacodynamic effects. |
SHARAN SIDHU; | 2023-12-01 |
| 460 | The Effect of Obesity Hypoventilation Syndrome on Exercise Capacity, Peripheral Muscle Strength, and Quality of Life in Obese Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity Hypoventilation Syndrome(OHS) is a disease characterized by daytime hypercapnia and sleep-disordered breathing without other causes of hypoventilation in individuals with a body mass index above 30 kg/m2. Sources state that obesity is at the basis of the metabolic changes seen in individuals with OHS. Obesity, together with cardiovascular system complications, lung volumes, work of breathing and sleep quality, creating the basis for respiratory problems. In addition, sedentary lifestyle habits, which are common in obese individuals, … |
GOKSEN KURAN ASLAN; | 2023-12-01 |
| 461 | The Effect of Sarcopenic Obesity on Sleep in Individuals With Obesity Hypoventilation Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity Hypoventilation Syndrome(OHS) is characterized by daytime hypercapnia and sleep-disordered breathing without other causes of hypoventilation in individuals with a body mass index above 30 kg/m2. It is stated that obesity is at the basis of the metabolic changes seen in individuals diagnosed with OHS. Also sedentary lifestyle habits, which are common in obese individuals, cause the risk of sarcopenia due to loss of muscle strength and mass, accumulation of adipose tissue in the body, … |
GOKSEN KURAN ASLAN; | 2023-12-01 |
| 462 | Acute Effect of Whole Body Vibration on Trunk Endurance and Balance in Obese Female Students PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is a global public-health issue, with rising incidence and prevalence, significant expenditures, and poor results. Obesity has become a worldwide epidemic in both developed and underdeveloped countries. A body mass index (BMI) of 30 kg/m2 is required for class I obesity, a BMI of 35 – 39.9 kg/m2 is required for class II obesity, and a BMI of 40 kg/m2 is required for class III obesity (morbidly obese). Obesity will be the likely situation for the majority of the adult population during the next two decades due to an abundance of calorie-rich food and apathy toward exercise. |
NESMA MORGAN ALLAM; | 2023-12-01 |
| 463 | Health Effects of Chronic Supplementation with A Natural Extract High in Hydroxytyrosol in Individuals At High Risk of Developing Age-related Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to ascertain the effects of chronic consumption of a hydroxytyrosol-rich extract from olive in a population at high risk of developing age-related pathologies such as type 2 diabetes and cardiovascular diseases. The markers measured will be associated with oxidative stress, inflammation, and homeostasis glucose and lipid profiles. Improvements in these parameters could potentially prevent the onset of pathologies associated with aging. |
MARÍA RAQUEL MATEOS BRIZ; | 2023-12-01 |
| 464 | Improving Cardiovascular Disease Risk Factors in Survivors of Adolescent and Young Adult Cancer With Obesity: Adaptation and Pilot Testing of A Behavioral Weight and Symptom Management Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There are close to 700,000 survivors of adolescent and young adult (AYA) cancer (aged 15 to 39 at diagnosis) in the US. Survivorship for AYAs is often complicated by long-term and late-effects. Cardiovascular disease (CVD), in particular, is a leading cause of death for cancer survivors and is a growing public health concern for survivors diagnosed as AYAs. Risk of CVD may be associated with treatment exposures and may be potentiated by weight gain and poor health behaviors. Healthy eating and physical activity are key behaviors for weight loss and maintenance and may be protective against CVD risk, … |
CAROLINE S DORFMAN; | 2023-12-01 |
| 465 | The Influence of Cardiovascular Risk Factors on Electrocardiographically and Hemodynamics Responses to Treadmill Exercise Test in Asymptomatically Subjects: A Clinical Perspective (ERGO-RISC) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational cross-sectional study is to analyze the effect of cardiovascular risk factors in healthy and asymptomatic populations. The main questions it aims to answer are: – Does the combination of the presence of different risk factors increase the risk for abnormalities appearing on electrocardiograms, such as ischemia, arrhythmia, and hemodynamics effects during and at the peak of effort of treadmill exercise test? – What are the main differences observed in the recovery period? Participants will answer an anamnesis of risk factors such as sex, race, age, familiar history of coronary artery disease, overweight or obesity, smoking, … |
PEDRO GABRIEL SENGER BRAGA; | 2023-11-30 |
| 466 | WE Project: 2.0 Grassroots Wellness Coaching. Using Grassroots Wellness Coaching to Enhance Reach and Sustainability of Behavioral Weight Management (Phase 2) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: African American adults that live in economically disadvantaged areas are at an increased risk for obesity and cardiometabolic disease. The treatment program being tested in this research study aims to address these factors and increase outcomes for the study population. The purpose of this research study is to find out about the feasibility and acceptability of using house chats (HC) as a model for a weight loss program in a real-world, community-based setting. |
MOGHBOEBA MOSAVEL; | 2023-11-28 |
| 467 | A Phase 3, Randomised, Double-blind, Parallel-group, 76-week, Efficacy and Safety Study of BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity and Type 2 Diabetes Mellitus PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults who are at least 18 years old and have a body mass index of 27 kg/m² or more. People can take part if they have type 2 diabetes and if they are currently being treated only with diet and exercise or with specific diabetes medications. Only people who have previously not managed to lose weight by changing their diet can participate. The purpose of this study is to find out whether a medicine called survodutide (BI 456906) helps people living with overweight or obesity who also have diabetes to lose weight. Participants are divided into 3 groups by chance, like drawing names from a hat. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under their skin once a week for about one and a half years. In addition to the study medicine, all participants receive counselling to make changes to their diet and to exercise regularly. Participants are in the study for about 1 year and 7 months. During this time, it is planned that participants visit the study site up to 14 times and receive 6 phone calls by the site staff. The doctors check participants’ health and take note of any unwanted effects. The study staff also regularly measure participants’ body weight. The results are compared between the groups to see whether the treatment works. |
BOEHRINGER INGELHEIM | 2023-11-27 |
| 468 | Efficacy and Safety of Cagrilintide 2.4 Mg S.c. in Combination With Semaglutide 2.4 Mg S.c. (CagriSema S.c. 2.4 Mg/2.4 Mg) Once-weekly Compared to Tirzepatide 15 Mg S.c. Once-weekly in Participants With Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at how well CagriSema compared to Tirzepatide helps people lower their body weight. CagriSema is a new investigational medicine developed by Novo Nordisk that combines Cagrilintide and Semaglutide. CagriSema is not yet being prescribed by doctors. Participant will get injections once a week throughout the treatment period. Participant will inject the study medicine under the skin with a pen injector in the thigh, stomach, or upper arm. After a first low dose, … |
NOVO NORDISK | 2023-11-27 |
| 469 | A Phase 3, Randomised, Double-blind, Parallel-group, 76-week, Efficacy and Safety Study of BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity Without Type 2 Diabetes PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults who are at least 18 years old and have * a body mass index (BMI) of 30 kg/m² or more, or * a BMI of 27 kg/m² or more and at least one health problem related to their weight. People with type 2 diabetes cannot take part in this study. Only people who have previously not managed to lose weight by changing their diet can participate. The purpose of this study is to find out whether a medicine called survodutide (BI 456906) helps people living with overweight or obesity to lose weight. Participants are divided into 3 groups by chance, like drawing names from a hat. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under their skin once a week for about one and a half years. In addition to the study medicine, all participants receive counselling to make changes to their diet and to exercise regularly. Participants are in the study for about 1 year and 7 months. During this time, it is planned that participants visit the study site up to 14 times and receive 6 phone calls by the site staff. The doctors check participants’ health and take note of any unwanted effects. The participants’ body weight is regularly measured. The results are compared between the groups to see whether the treatment works. |
BOEHRINGER INGELHEIM | 2023-11-25 |
| 470 | A Randomized, Double-blind, Placebo-controlled, Multiple-ascending-dose Phase Ic Study Evaluating The Safety, Tolerability, and Pharmacokinetics of ZT002 Injection in Participants With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will comprise a randomized, double-blind, placebo-controlled, multiple-ascending-dose, safety, tolerability, and pharmacokinetics study of ZT002 in participants with Overweight or Obesity. |
XIAOLI LI; | 2023-11-21 |
| 471 | A Phase 3, Randomised, Double-blind, Parallel-group, Event-driven, Cardiovascular Safety Study With BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity With Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, And/or at Least Two Weight-related Complications or Risk Factors for CVD PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults who are at least 18 years old and have a body mass index (BMI)bof 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related to their weight or risks of cardiovascular disease can participate. Participants must have previously tried to lose weight by changing their diet. The purpose of this study is to find out whether people with overweight or obesity who take a medicine called survodutide (BI 456906) are less or more likely to develop serious cardiovascular problems. It also aims to find out whether health parameters like blood pressure improve. Overweight and obesity are linked to cardiovascular disease. Survodutide is a medicine that is developed to help people with obesity or overweight to lose weight. Participants are divided into 3 groups of almost equal size. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under the skin once a week. All participants also receive counselling on diet and physical activity. Participants are in the study for up to 2 years and 3 months. During this time, it is planned that participants visit the study site up to 21 times and attend remote visits by video calls. During these visits, the doctors check participants’ cardiovascular and overall health. The results are compared between survodutide and placebo groups. The study staff also takes note of any unwanted effects. |
BOEHRINGER INGELHEIM | 2023-11-20 |
| 472 | Hepatoprotective Measures for Children at High Risk of Non Alcoholic Fatty Liver Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Non Alcoholic Fatty Liver Disease (NAFLD) is a spectrum of disease, ranging from simple fatty deposition (steatosis) to inflammation (steatohepatitis), fibrosis, cirrhosis, and end-stage liver failure. In childhood, it may be associated with a metabolic syndrome or with obesity, or even in normal children. Liver biopsy has always been the gold standard method for diagnosing and staging NAFLD. However, the urge of non-invasive biomarkers or imaging techniques has been recommended. This study will evaluate the use of the LIVERFASt biomarkers for early detection and staging of NAFLD. |
MANAL H EL-SAYED; | 2023-11-19 |
| 473 | A Master Protocol for A Randomized, Controlled, Clinical Trial of Multiple Interventions for Chronic Weight Management in Adult Participants With Obesity or Overweight PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA’s complete. |
ELI LILLY | 2023-11-17 |
| 474 | A Phase 2, Parallel-Group, Double-Blind, 4-Arm Study to Investigate Weight Management With LY3305677 Compared With Placebo and in Adult Participants With Obesity or Overweight PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study, performed under a master protocol W8M-MC-CWMM (NCT06143956), is to investigate weight management efficacy and safety with LY3305677 compared with placebo and in adult participants with obesity or overweight. The study will last about 62 weeks. |
ELI LILLY | 2023-11-17 |
| 475 | Food and Resources Expanded to Support Health and Type 2 Diabetes (FRESH-T2D) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Food insecurity, poor nutrition, and economic disadvantage are critical social determinants of health that contribute to disparities in type 2 diabetes mellitus (T2DM), a serious diet-sensitive chronic disease affecting more than 20% of food insecure adults. There is a demonstrable need for food-focused interventions to address the diet quality of persons with, or at risk of, T2DM. Completion of the pilot study will produce recruitment, retention, adherence, and cost data for a future definitive randomized controlled clinical trial, bringing us closer to the long-term goal of a tested, … |
UNIVERSITY OF ARIZONA | 2023-11-17 |
| 476 | Detection of Pre-Diabetes in Overweight and Obese Children and Adolescents in Assiut Governorate PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Descriptive cross section study To detect prediabetes in overweight and obese children and adolescents in Assiut Governorate and to find out the possible risk factors. |
MAHMOUD BAKR GABER; | 2023-11-15 |
| 477 | A Phase I Randomized, Single-blind, Placebo-controlled Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD6234 Following Repeat Dose Administration in Participants With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A study in healthy male and female participants of non-childbearing and childbearing potential who have overweight or obesity |
ASTRAZENECA | 2023-11-13 |
| 478 | Follow-up of Children Born From A Randomized Controlled Trial Assessing A Preconception Lifestyle Intervention in Women With Obesity and Infertility PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Maternal preconception obesity and adverse gestational metabolic health increase the risk of childhood obesity in offspring. A group of investigators from Université de Sherbrooke therefore developed a lifestyle intervention starting during preconception in women with obesity and infertility, … |
JEAN-PATRICE BAILLARGEON; | 2023-11-13 |
| 479 | A Pilot Study to Examine Metabolic Flexibility As A Mechanism for Diet- Induced Epigenetic Alterations in Male Gametes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study in 10 men to test the hypothesis that perturbations in substrate flux and the circulating metabolic and pro-inflammatory milieus during a high-fat diet paradigm will modulate DNA methylation of genes in sperm associated with obesity and cardiometabolic dysfunction. |
EMILY W. FLANAGAN; | 2023-11-11 |
| 480 | Impacts of Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery: A Prospective Randomized Double Blinded Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the usefulness of adding aminophylline to dexmedetomidine intravenous infusion intraoperatively on oxygenation and lung mechanics in chronic obstructive pulmonary disease (COPD) morbidly obese patients undergoing bariatric surgery. |
SOLIMAN RAMADAN AHMED NASER; | 2023-11-11 |
| 481 | Static Posturographic Analysis for Different Weight Categories in Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to investigate the impact of different weight categories of adolescents on the center of pressure displacement throughout posturographic analysis test |
DINA S. NOAMAN; | 2023-11-10 |
| 482 | Effects of Supplementing The Bifidobacterium Longum BL21 on BMI, Metabolic Indicators, and Gut Microbiota in Overweight/Obese Adults: A Randomized, Double-blind, Placebo-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to investigate the effects of Bifidobacterium longum subspecies BL21 on BMI, metabolic indicators, and changes in gut microenvironment microbiota in overweight/obese adults. The blood, urine, and feces samples of the subjects need to be collected at 0,4 and 8 week and promptly tested in the laboratory. During the intervention period, all groups of subjects were required to take the corresponding products daily and record adverse reactions. |
TAO ZHOU; | 2023-11-10 |
| 483 | Balanced Nutritional Diet Intervention on Body Composition Among Different FTO RS9939609 Gene in Obese Young Women In Bandung, Indonesia: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Food intake along with the gene are important factors that influence human nutrition status and health. Indonesia has a balanced nutrition diet guide for ideal food consumption. The FTO rs9939609 gene is known to be related to obesity. This study aimed to examine the effect of a balanced nutritional diet intervention on body composition among different single nucleotide polymorphisms (SNP) of the FTO rs9939609 gene in obese young women in Bandung City, West Java, Indonesia. |
PRODI GIZI; | 2023-11-08 |
| 484 | A Hybrid Mobile Phone Family Intervention to Prevent Childhood Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Consumption of sweetened beverages, media-viewing, and physical activity patterns are often established during early childhood, and family-based obesity interventions show effectiveness in shaping healthy behaviors and weight outcomes for young children, including Latino children. Missing from these interventions, however, are methods to increase accessibility and dissemination to multiple family caregivers. The proposed work will use a randomized study design to evaluate the impact a family-based early childhood obesity intervention for Latino families that incorporates evidence-based strategies of in-person childhood obesity interventions, mobile phones, and leverages important determinants of Latino health (e.g. familism, … |
ALMA GUERRERO; | 2023-11-06 |
| 485 | Creation of Side-to-Side Compression Anastomosis Using The GT Metabolic Solutions Magnet System, GJ Biofragmentable to Achieve Gastro-Ileal or Gastro-Jejunal Diversion in Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical research study is to evaluate the feasibility of the GT Metabolic Solutions Magnet System, GJ Biofragmentable (MagGJ System) for creation of a side-to-side anastomosis for gastro-ileal or gastro-jejunal diversion in obese adults. |
GT METABOLIC SOLUTIONS | 2023-11-06 |
| 486 | Comparative Study Between The Effect of Volume-Controlled Ventilation and Pressure-Controlled Ventilation Volume Guaranteed in Obese Patients in Laparoscopic Assisted Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to compare the efficacy of the pressure controlled ventilation volume-guaranteed (PCV-VG) versus volume-controlled ventilation (VCV) modes as regards lung compliance and oxygenation index in obese patients undergoing laparoscopic assisted surgery especially in Trendelenburg position. |
AHMED MAAMOUN MAAMOUN SOLIMAN; | 2023-11-05 |
| 487 | Effects of Individualized Positive End-Expiratory Pressure (PEEP) on Oxygenation, Hemodynamic Variables, and Incidence of Early Postoperative Atelectasis in Patients Undergoing Laparoscopic Bariatric Surgery: A Prospective Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the effectiveness of intraoperative individualized positive end-expiratory pressure (PEEPIND) titration, compared to fixed positive end-expiratory pressure of 5 cmH2O, on oxygenation, hemodynamic variables, and early postoperative complications in obese patients undergoing laparoscopic bariatric surgery. |
HEBA ZAKARIA MOHAMED KHATTAB; | 2023-11-05 |
| 488 | Impact of Weight Variation on Cop Displacement During Unperturbed Standing Conditions in Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to investigate the impact of variant weights in adolescents during unperturbed standing conditions. |
AMIRA HUSSIN HUSSIN MOHAMMED; | 2023-11-01 |
| 489 | Metabolic Dysfunction Associated Fatty Liver Disease in Long-Term Cholecystectomy: A Cross-sectional Case-control Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to examine the association between metabolic associated fatty liver disease (MAFLD) in participants who had undergone cholecystectomy and those who had not undergone cholecystectomy. MAFLD is defined as hepatic steatosis(with ultrasonography) entity in addition to the presence of overweight or obesity, diabetes mellitus, or evidence of metabolic dysfunction. In this way, the long-term effects of cholecystectomy surgeries, which are commonly performed in the society and thought to be harmless, will be evaluated. |
SEMIH SEZER; | 2023-11-01 |
| 490 | Effectiveness of Digital Versus Hybrid Interventions in Promoting Nutrition Knowledge Among Adolescent Girls: A Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study primarily aims to compare the efficacy of different approaches to nutrition education intervention delivery in improving nutrition knowledge (NK) among Saudi adolescent girls. A secondary aim is to compare the effectiveness of these interventions in enhancing dietary habits and reducing Generalized Anxiety Disorder (GAD) scores.A randomized sample of 104 Saudi adolescent girls aged 16-18 years from a single high school in Makkah city enrolled in a 4-week lifestyle educational intervention for health promotion. Participants were randomly assigned to either a hybrid or a fully digital nutritional education program. Outcome measures included knowledge (NK), … |
ESSRA NOORWALI; | 2023-11-01 |
| 491 | A 6-Month, Randomized, Double-Blind, Placebo-controlled, Phase 2a Study of The Effects of HU6 on Energy Metabolism, Muscle and Liver Substrate Metabolism, and Mitochondrial Function in Subjects Who Are Overweight or Obese With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, placebo-controlled parallel group study of HU6 and placebo in subjects who are overweight or obese with T2D. The study will be conducted in 4 stages. |
RIVUS PHARMACEUTICALS | 2023-11-01 |
| 492 | Acute Effects of Animal Versus Plant-Based Protein Within A Realistic High-Fat Meal on Metabolic and Inflammatory Factors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Shifting away from diets high in animal products towards more plant predominant diets is recommended by many health organizations to both reduce the negative environmental impacts of animal agriculture and to improve health outcomes. As a result, a number of plant-based meat alternatives such as Beyond Meat have been formulated to promote increased plant consumption. However, evidence is limited on the impact of newer plant-based meat alternatives on common cardiometabolic risk factors. The investigators aim to compare the acute metabolic, gastrointestinal, and inflammatory effects of a plant-based meat alternative (i.e., … |
BRYANT KEIRNS; | 2023-11-01 |
| 493 | Population Pharmacokinetics of Paracetamol in Overweight and Obese Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to define population pharmacokinetic parameters and variability factors for paracetamol and its metabolites in overweight and obese children compared to children with normal weight for age and sex. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-11-01 |
| 494 | Investigating The Impact of Consuming Cinnamon Powder on The Body Composition Among Obese University Students in Lahore PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obesity is a global health concern that significantly affects individuals, and its prevalence is still rising at an alarming rate. While various treatments are available, they often come with unwanted side effects. As a result, there is a growing interest in natural remedies including various herbs and spices such as cinnamon that have a favorable impact on overall health and disease conditions. |
MUHAMMAD SHAHBAZ; | 2023-11-01 |
| 495 | Effect of Pyramidal Training on Selected Risk Factors of Atherosclerosis in Women With Central Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be conducted on fifty women with central obesity. Their ages will be from 30-40 years old. They will be selected from Al Hayat specialized Hospital in Cairo, Egypt and The participants will be randomly assigned into two equal groups: Group (A): study group, 25 participants will receive pyramidal training by treadmill for 40 minutes per session three sessions per week for eight weeks in addition to the diet health advices. Group (B): Control group, 25 participants will receive diet health advices. The subjects will be selected from El Haya specialized Hospital, Cairo. |
MARWA MAHMOUD ELSAYED MAHMOUD; | 2023-11-01 |
| 496 | Efficacy and Safety of Thread Embedding Acupuncture Combined With Auricular Acupuncture for Overweight and Obesity: Randomized Placebo-Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Overweight and obesity are chronic non-communicable diseases with a rapidly increasing global prevalence. They constitute risk factors for various chronic conditions, including cardiovascular diseases, type 2 diabetes, chronic kidney disease, cancer, as well as musculoskeletal disorders and numerous other disorders, significantly impacting the quality of life. Numerous non-pharmacological interventions have been employed in the management of these conditions. Particularly, Auricular acupuncture (AA) has been a widely used and established method for weight management, owing to its effectiveness, safety, and convenience. Recently, … |
BUI PHAM MINH MAN; | 2023-10-30 |
| 497 | Assessment of FibbroScan in Diagnosing MASLD Among The Chinese Population With Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The non-invasive evaluation of liver steatosis and fibrosis with FibroScan is a routinely procedure in clinical practice for people with obesity. However, there are still considerable uncertainties regarding the potential influence of confounding factors and the optimal application of cut-off values for obesity. The goal of this observational study is to learn about the optimal application of cut-off values of for Chinese people with obesity. |
HONGMEI ZHU; | 2023-10-24 |
| 498 | Phase 1 Clinical Trial of ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Endometrial cancer (EC) is the fourth most common cancer in United States women, and alarmingly, the frequency and mortality from EC continues to rise, in part due to the obesity epidemic. Obese women with EC have a 6.3-fold increased risk of death from this disease, as compared to their non-obese counterparts. Patients with advanced/recurrent EC are unlikely to be cured by surgery, conventional chemotherapy (paclitaxel + carboplatin is the standard first-line treatment), radiation, or a combination of these. Thus, … |
VICTORIA BAE-JUMP; | 2023-10-23 |
| 499 | Energy Balance and Mitochondrial Function in Human Genetic Models of Mitochondrial Stress-mediated Obesity Resistance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overarching aim of this observational study is to determine alterations in energy balance while exploring the underlying cellular mechanisms in human genetic models of mitochondrial stress. In a case-control design, individuals with pathogenic mitochondrial DNA mutations will be compared to healthy controls matched for sex, age, and physical activity level. Participants will attend a screening visit and an experimental trial including assessments of energy expenditure, appetite sensation, energy intake, and muscle and subcutaneous adipose tissue biopsy samples. |
MATTEO FIORENZA; | 2023-10-20 |
| 500 | Efficacy of Isocaloric Mediterranean Diet and Low-fat Diet in Overweight/Obese MASLD Subjects With Respect to PNPLA3 Single Nucleotide Polymorphism: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is designed as a 12-week randomized controlled dietary intervention in individuals who had been diagnosed with NAFLD in the last 6 months and whose body mass index is above 25 at the time of participation in the pre-screening. The study sample is determined as 150 subjects and randomization will be done by stratification according to PNPLA3 genotype. At baseline, hepatic steatosis and fibrosis will be measured with Fibroscan, body composition will be analyzed, and transaminases and sugar and lipid metabolism indicators will be examined. The study will be conducted in parallel groups, … |
ZEYNEP BANU GUNGOR; | 2023-10-19 |