Clinical Digest: Recent Clinical Trials on Stroke
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Stroke. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
This curated list is brought to you by the Clinical Digest Team. Experience the cutting-edge capabilities of Clinical Digest, an innovative AI-powered clinical research platform that empowers you to read articles, write articles, get answers, conduct literature reviews and generate research reports.
Experience the full potential of our services today!
TABLE 1: Clinical Digest: Recent Clinical Trials on Stroke
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Evaluation of A POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The EPOCA study (Evaluation of a POlypill and Colchicine for risk reduction in patients with established Atherosclerotic cardiovascular disease) will be a randomized, superiority, parallel, 2×2 factorial, multicenter clinical trial which will include at least 7713 and up to a maximum of 10797 participants with established atherosclerotic cardiovascular disease. |
LUCAS TRAMUJAS; | 2025-05-01 |
| 2 | Comparison of Intensive Lipid-Lowering Therapy With A Statin-Ezetimibe Combination (Without Aspirin) Vs. Statin Monotherapy (With Aspirin) In Asymptomatic Patient With Coronary Artery Calcification PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: A Multicenter, randomized trial comparing the efficacy and safety of intensive lipid-lowering therapy using a statin-ezetimibe combination without aspirin versus statin monotherapy with aspirin in asymptomatic patients with coronary artery calcification |
SEUNG-WHAN LEE; | 2025-05-01 |
| 3 | A Prospective Observational Cohort Study of Predictive Biomarkers Related With Ischemic Cerebrovascular Disease PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this single-center prospective observational study is to identify and evaluate new biomarkers for ischemic cerebrovascular disease (ICVD) to aid in early diagnosis, individualized treatment planning, and prognosis prediction in affected patients. The main questions it aims to answer are: Can specific biomarkers help in identifying high-risk individuals before disease onset? Can these biomarkers predict disease progression and treatment response? Researchers will compare patients diagnosed with ICVD and healthy controls from a medical check-up center to assess differences in biomarker expression and their clinical significance. Participants will: Provide blood, cerebrospinal fluid, urine, … |
DAISHI TIAN; | 2025-05-01 |
| 4 | Direct-to-angio Approach From LoCal HOspitals Based on A PoInt-of-care BLOod Test for LVO (COPILOT): An Effectiveness Cluster Randomized Crossover Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Direct-to-angio approach from loCal hOspitals based on a PoInt-of-care bLOod Test for LVO (COPILOT) is a multi-center, prospective, cluster-randomized crossover trial that will evaluate if the triage assessment to thrombectomy puncture time is shorter after performing the LVOne testing compared to current management standards in patients with suspected large vessel occlusion. |
JUAN VICENTY; | 2025-05-01 |
| 5 | Ten-Year Outcomes of Randomized Comparison of Drug-eluting Stent Implantation Versus Optimal Medical Treatment in Patient With Chronic Total Occlusion: DECISION-CTO Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare long term efficacy of drug-eluting stent implantation compare to optimal medical treatment in patient with chronic total occlusion in a very long-term follow-up (minimum 10 years) period. |
SEUNG-JUNG PARK; | 2025-05-01 |
| 6 | Comparison of 5G Mobile Stroke Unit to Standard Management By Emergency Medical Services For Acute Ischemic Stroke Treatment：A Multicenter, Prospective, Open-label, Blinded Endpoint , Week-wise Randomized, Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: While Mobile Stroke Units (MSUs) are considered as a relatively new model for acute stroke treatment, 5G Mobile Stroke Units (5G MSUs) have already come into service for stroke treatment in some parts of China. Since limited evidence has been found to suggest their advantages over conventional Emergency Medical Services (EMS), … |
DOU LI; | 2025-05-01 |
| 7 | Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Stenosis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study utilized different hemodynamic parameters of transcranial color-coded Doppler (TCCD) and transcranial Doppler (TCD) to conduct ultrasonic grading evaluation on middle cerebral artery (MCA) stenosis severity in patients with severe extracranial internal carotid artery stenosis, as well as intracranial V4 segment stenosis severity in patients with severe vertebral artery (VA) origin stenosis. The aim was to establish ultrasonic diagnostic criteria and provide reference basis for clinical treatment decision-making. Clarify the distribution of stroke risk factors, establish and evaluate stroke risk identification and prediction models. Patient cohort: Individuals undergoing carotid artery stenting or vertebral artery stenting, … |
YINGQI XING; | 2025-05-01 |
| 8 | Effect of Acetaminophen on Neurological Outcome in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Neuro-inflammation response plays an important role in the development of acute ischemic stroke(AIS). The aim of this study was to conduct a prospective randomized controlled study on the effect of acetaminophen on long-term neurological prognosis in AIS patients undergoing endovascular treatment(EVT). The primary outcome was the incidence of neurological independence (mRS 0-2, … |
RUQUAN HAN; | 2025-05-01 |
| 9 | Personalized Rehabilitation Pathways to Maximal Motor Functional Return Through An AI Recovery Prediction System for Diverse Stroke Survivors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project addresses the imminent challenge of providing adequate motor rehabilitation to a growing number of stroke survivors amidst the ageing population, decreasing age of stroke, and shortage of physical/occupational therapists in Hong Kong through AI and precision rehabilitation. To reduce the socioeconomic burden from the stroke survivors’ loss of independence and their care (\>HK$15 billion/year), … |
CHEUNG CHI KWAN VINCENT; | 2025-05-01 |
| 10 | Effectiveness of Real Home Settings Via Virtual Reality Task Oriented Training on Upper Limb Function in Patients With Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke rank second among the top causes of death, affecting millions of people in the worldwide. It has been reported that hemiplegia is the most common sequelae after stroke, accounting for about 50%-70% of all sequelae of the disease. About 75% of stroke patients are accompanied by different degrees of upper limb dysfunction, … |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2025-05-01 |
| 11 | A Single-Center, Open-Label, Non-Inferiority Clinical Study of Angong Niuhuang Pills With Different Bovine Bezoar Formulation Sources in The Treatment of Acute Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a single-center, open-label, controlled clinical trial that prospectively enrolls 100 participants (40 in the Z11020076 group, 40 in the Z20063878 group, and 20 in the blank control group) to collect clinical data, imaging data, and biospecimens over an 84-day follow-up period. The primary objective is to compare the efficacy and safety of Angong Niuhuang Pills from Beijing Tongrentang (Approval No. Z11020076) and Wuhan Jianmin Dapeng Pharmaceutical Co., … |
DAISHI TIAN; | 2025-05-01 |
| 12 | Accuracy of Transcranial Colour Coded Duplex Compared With CT Angiography in Diagnosing Arterial Obstructions in Acute Ischemic Strokes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigator will compare accuracy of transcranial colour coded duplex with CT angiography in detecting arterial obstructions in patients presenting or with history of cerebrovascular ischemic strokes |
HASSAN HAMDY HAMED; | 2025-05-01 |
| 13 | The Comparison of Safety and Treatment Results Between Early (<6 Months) and Late (> 6 Months) Vagus Stimulation for Post-stroke Motor Rehabilitation: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In previous study, Vagus nerve stimulation was constricted to patients 9 months after stroke. In this randomized phase I trial, we would apply vagus nerve stimulation in an early stage (\<6 month) and observe its theraputic effect on motor function after ischaemic Stroke.We hypothesized that the early stimulation could be safe and more beneficial compared to stimulation in late stage. |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2025-05-01 |
| 14 | NanO2 in Large VessEL Occlusion Stroke (NOVEL): A Multicentre Single-blind, Randomised, Placebo-controlled Blinded Biomarker End-point Clinical Trial of Perfluorocarbon in Acute Ischaemic Stroke Due to Large Vessel Occlusion PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) clinical trial aiming to investigate a possible new treatment to limit damage to the brain caused by a stroke. Strokes that are caused by a clot blocking an artery in the brain (‘ischaemic’ strokes) starve brain tissue of oxygen and nutrients. Over a short period of time without oxygen, this tissue becomes permanently damaged. The trial aims to investigate the effects of a drug that carries extra oxygen, called NanO2, … |
NHS GREATER GLASGOW AND CLYDE | 2025-05-01 |
| 15 | Enhancing Reading Recovery in Aphasia with TDCS and PMT PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed for individuals with aphasia, a language disorder that affects many stroke survivors, making it difficult to read, speak, and understand language. Up to 70% of people with aphasia struggle with reading, which impacts their ability to communicate, work, and engage in daily life. The study aims to test a new approach to reading rehabilitation by combining Phono-Motor Treatment (PMT), a language therapy adapted to improve reading, with transcranial direct current stimulation (tDCS), a safe and painless brain stimulation technique. tDCS delivers a mild electrical current to the brain, … |
OLGA BOUKRINA; | 2025-05-01 |
| 16 | Reliability of Sensor-Derived Measurements of The SENSorized Fugl-Meyer (FMA) in Subjects with Stroke Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted at a single research center, the main objective of the study will be to evaluate the efficacy, safety, and accuracy of a medical device that has not yet been commercialized; therefore, it is still under development or testing and is not yet available for private use and is not for profit (nonprofit). Fifty participants will be recruited from subjects afferent to the outpatient and inpatient neuro-motor rehabilitation clinics of IRCCS Fondazione Don Carlo Gnocchi in Florence, Italy, and afferent to the outpatient and inpatient rehabilitation clinics of Elias University Emergency Hospital in Bucharest, … |
FONDAZIONE DON CARLO GNOCCHI ONLUS | 2025-05-01 |
| 17 | Intra-Arterial Tenecteplase Following Endovascular Thrombectomy for Large Vessel Occlusion Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the safety and feasibility of using intra-arterial Tenecteplase in patients undergoing blood clot extraction for treatment of acute ischemic (non-bleeding) stroke. Tenecteplase is a drug that is currently FDA-approved to treat a heart attack but not currently approved for stroke treatment. |
RAHUL KARAMCHANDANI; | 2025-05-01 |
| 18 | AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors. The study compares three groups: one performing aerobic cycling exercise at an intensity that increases lactate levels, one doing low-intensity exercise, and one receiving health education without exercise. All participants will complete motor learning tasks and undergo brain stimulation testing (using transcranial magnetic stimulation, or TMS) to assess how well the brain responds to training. The goal is to understand whether different types of exercise can improve brain function, movement, and memory, … |
KEITH MCGREGOR; | 2025-05-01 |
| 19 | Cross-Stroke Therapy Effects With BCI and FES Stimulation: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this neurorehabilitation explorative study is to investigate how a closed-loop Brain-Computer Interface Functional Electrical Stimulation (BCI-FES) therapy, used within the intended purpose for hand rehabilitation, may impact swallowing difficulties (dysphagia) and language disorders (aphasia) in post-stroke patients. |
MICHAEL KNOFLACH; | 2025-05-01 |
| 20 | Safety, Tolerability and Efficacy of Adjunctive TBO-309 in Reperfusion for Stroke With Tandem Occlusion PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Co-STAR is a multicenter, prospective, open-label, Bayesian Optimal Phase 2 (BOP2) trial that aims to assess the safety and efficacy of adjunctive intravenous TBO-309 in Acute Ischaemic Stroke (AIS) patients with tandem occlusion receiving intra-cranial endovascular thrombectomy (EVT) and acute extracranial carotid artery stenting. Co-STARS study will test the hypothesis that patients with tandem occlusion treated with EVT and acute stenting in conjunction with TBO-309 will: * have persistent stent patency without requiring rescue therapy with GPIIb/IIIa inhibitors and * not experience high rates of symptomatic intra-cranial haemorrhage (sICH). Patients with tandem occlusion undergoing EVT and acute stenting will receive intravenous TBO-309 bolus and infusion. TBO-309 is a potent, selective and ATP competitive PI3K\[beta\] inhibitor which reduces platelet activation adhesion/aggregation particularly under conditions of disturbed blood flow and promotes platelet disaggregation. By targeting PI3K\[beta\], TBO-309 specifically inhibits thrombosis whilst minimizing the impact on normal hemostasis. |
FERDINAND MITEFF – INTERVENTIONAL NEUROLOGIST; | 2025-05-01 |
| 21 | Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy: A Phase I Drug Pilot Research Plan PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the safety and feasibility of using inhaled nitric oxide (iNO) in patients undergoing intra-arterial mechanical thrombectomy (blood clot extraction or IAMT) for treatment of acute ischemic (non-bleeding) stroke (AIS). |
WILLIAM R STETLER; | 2025-05-01 |
| 22 | Mild Cognitive Impairment After Minor Stroke: Evaluation of Early-phase Telecare Programs (Psychoeducation and Computerized Cognitive Stimulation) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Minor strokes (few acute neurological symptoms ; NIHSS score \<5), represent almost 65% of cerebrovascular ischemic events. The increasing incidence of stroke in people under 65, together with advances in diagnostic and revascularization techniques, mean that post-stroke life expectancy is now in the order of decades. Most patients with minor stroke are rapidly discharged from hospital, with follow-up focused on secondary prevention and they are offered little or no rehabilitation. However, up to 70% of patients with minor stroke experience difficulties resuming their social or professional activities, ... |
HOSPICES CIVILS DE LYON | 2025-05-01 |
| 23 | Evolution of Burden of AF Biomarkers, Left Atrial Characteristics, Demographics,and Risk Factors in AF Detected After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Each year, 7.8 million people worldwide experience an ischemic stroke, often caused by atrial fibrillation (AF). AF is a major contributor to severe, disabling, and deadly strokes. About 20% to 30% of ischemic stroke patients have AF before their stroke. Of the remaining 70% to 80% without known arrhythmias, up to 24% are newly diagnosed with AF after intensive cardiac monitoring, … |
LUCIANO A SPOSATO; | 2025-05-01 |
| 24 | Hybernia Delta H (ΔH) Brain Cooling System For: Post-Mechanical Endovascular Cerebral Cooling PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Reducing the temperature of tissue or organs (hypothermia) produces a protective state, through multiple molecular mechanisms, against adverse effects that arise from disrupted organ blood flow, e.g. in acute ischemic stroke (AIS). AIS is often caused by a blood clot that occludes a brain artery which, in turn disrupts brain blood flow. In large vessel occlusions, the current standard includes mechanical thrombectomy (MT), a minimally-invasive procedure that aims at removing the clot via endovascular means. In this case, brain cooling can lead to protection (neuroprotection) not only from the adverse effects of stroke/ischemia itself, … |
MARC RIBO; | 2025-05-01 |
| 25 | PeRsonAlised Community Based TelerehabIlitation Post StrokE to Increase Rehabilitation Time and Improve Motor Recovery: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: About two thirds of people after stroke have some level of disability. Rehabilitation helps to reduce disability and supports people to return to a meaningful life. We know that the more rehabilitation you do especially, within the first six months after stroke, the better the outcome. However, rehabilitation services, especially in the community, are often lacking, … |
LORNA PAUL; | 2025-05-01 |
| 26 | Delay Avoiding Primary Evaluation for Thrombectomy for Acute Stroke Patients with Large Vessel Occlusion in The Angiography Suite (DIRECT) Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare two strategies for treating adults with suspected large vessel occlusion stroke within 7 hours of symptom onset. Researchers will evaluate whether direct transfer to the neurointerventional angiography suite improves recovery and reduces disability compared to the conventional approach of first being evaluated in the emergency department. The study will also assess safety and other health outcomes to guide care for stroke patients. |
SANTIAGO ORTEGA GUTIERREZ; | 2025-04-30 |
| 27 | Upper Limb Function Following Transcutaneous Electrical Spinal Cord Stimulation in Individuals With Hemiplegic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the feasibility and impact of transcutaneous electrical stimulation of the spinal cord (TESS) on the recovery of post-stroke individuals who have upper limb hemiparesis. It will compare outcomes measures between individuals who receive upper limb task specific training with TESS and individuals who receive task specific training of the upper limb with Sham, or fake, TESS. |
MARY ELLEN STOYKOV; | 2025-04-30 |
| 28 | Development and Validation of An Actimetric Protocol to Quantify Physical Activity and Sedentary Behaviour in Post-stroke Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this project is to develop an actimetry protocol based on a system of motion sensors, such as accelerometers and pressure insoles. These sensors will be used to analyze arm and leg movements in individuals who have experienced a stroke. Throughout the study, we will adjust certain parameters-such as sensor placement and measurement frequency-to optimize data quality. We will also refine data analysis methods to better identify the types of movements performed (upper and lower limbs), estimate energy expenditure, and recognize different postures adopted by the participant (sitting, standing, … |
THIERRY LEJEUNE; | 2025-04-28 |
| 29 | Efficacy and Safety of Intermittent Theta Burst Stimulation in Acute Anterior Circulation Ischemic Stroke Patients Undergoing Mechanical Thrombectomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic stroke patients who have undergone successful mechanical thrombectomy (MT). The study population includes adults aged 18-85 with NIHSS scores 5-25 post-MT and eTICI≥2b reperfusion. |
YI YANG; | 2025-04-25 |
| 30 | Effect of Applying Oral Hygiene Care on Swallowing in Stroke Patients With Oropharyngeal Dysphagia: A Multi-Arm Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-stroke dysphagia (PSD) is a common condition, affecting over 40% of patients within hours to days following a stroke. It is associated with negative outcomes, including higher rates of mortality and dependency, incidence of aspiration, pneumonia, and malnutrition. The presence of dysphagia, combined with poor oral health, significantly increases the risk of these adverse outcomes. However, there is limited knowledge regarding the impact of oral care practices on these outcomes, as well as their effect on oral function and swallowing in acute stroke patients. The optimal approach to delivering oral care remains undefined, … |
BARBARA JANSSENS; | 2025-04-21 |
| 31 | The Effects of Overground Robot-Assisted Gait Training (o-RAGT) and Recumbent Bicycle Training on Muscle Mass, Physical Function, and Fall Efficacy in Subacute Stroke Patients With Pre-Sarcopenia : A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the effects of overground robot-assisted gait training (o-RAGT) and recumbent bicycle training on muscle mass, physical function, and fall efficacy in subacute stroke patients with pre-sarcopenia. Stroke survivors often experience significant muscle loss and functional decline, especially during the subacute phase. o-RAGT, using a wearable robotic exoskeleton, provides intensive, repetitive gait training on real ground, enhancing sensory feedback and muscle activation. Recumbent bicycle training offers stable lower extremity exercise, … |
DONG MIN PARK; | 2025-04-21 |
| 32 | Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the control effect of smart wearable devices on key risk factors in the high-risk populations for stroke |
AFFILIATED HOSPITAL OF NANTONG UNIVERSITY | 2025-04-20 |
| 33 | Effectiveness of Off-script Diagnosis & Differential Diagnosis (D&D) Training in Improving Residents’ Competence in Acute Ischemic Stroke Diagnosis and Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study is a single-center, randomized, open-label, controlled, endpoint-blinded study to assess the effect of off-script diagnosis \& differential diagnosis (D\&D) training in improving the residents’ knowledge of acute ischemic stroke in China. We will enroll 22 residents and assess the score of mASMaQ 30 days after randomization. |
JUN NI; | 2025-04-20 |
| 34 | Reduction of Edema With A Specialized Cocktail for Ultra-early Management in Intracerebral Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability rates, often worsened by perihematomal edema (PHE), which increases intracranial pressure and leads to poor outcomes. Preclinical studies suggest that a pharmacological cocktail (PPA) may help reduce cerebral edema by modulating potassium balance, preserving aquaporin-4 expression, and enhancing lymphatic drainage. This multicenter, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-04-20 |
| 35 | Functional ElectroAnatomiC Isochronal Late Activation Mapping for Empiric VT Ablation Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, prospective, parallel, randomized controlled trial to test for non-inferiority with an ILAM-guided VT ablation compared to conventional voltage- based ablation. The study has two treatment arms: conventional voltage mapping and ablation (control arm). In the investigational arm, the ablation strategy is guided by ILAM to target deceleration zones, blinded to voltage mapping. In the control arm, ablation will be performed to extensively ablate all low voltage regions (\<1.5mV) during sinus rhythm, right ventricular (RV) pacing, or left ventricular (LV) pacing, with discretionary use of pacemapping and activation mapping. In both arms, ... |
RODERICK TUNG; | 2025-04-15 |
| 36 | Effect of Informatıon Gıven to Caregıvers of Stroke Patıents Wıth Percutaneous Endoscopıc Gastrostomy on Care Burden and Self-care Affaırs: A Randomızed Controlled Trıal PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is one of the serious neurological disorders that occur due to decreased blood flow to a certain part of the brain due to vascular injuries. Stroke ranks second in Europe among the causes of death in the world, fourth in the USA and second in Turkey. More than half of these patients who continue to live become partially or completely dependent on others for self-care and daily living activities. During this process, … |
CEYLAN KISIAL; | 2025-04-15 |
| 37 | Implementation of A HABIT-ILE Intervention at The William Lennox Neurological Centre for Sub-acute Adult Post-stroke Patients (<6 Mois): A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Using a randomized controlled trial design, in an hospital environment, possible changes induced by the Hand-arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) treatment program will be investigated in functional activities of daily living, motor and cognitive assessment of patients with sub-acute post-stroke |
YANNICK BLEYENHEUFT; | 2025-04-15 |
| 38 | Multicenter Trial to Evaluate The Safety and Effectiveness of The Cardiohelp System for Up to 30 Days of Support in Children With Severe Cardiac Failure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this multicenter observational clinical trial is to evaluate the safety and effectiveness of the Cardiohelp System for VA-ECMO in children with cardiac failure. The main question\[s\] it aims to answer are: * What is the safety and effectiveness of the Cardiohelp device for pediatric ECMO? * What are the optimal performance specifications of the Cardiohelp device in children? Should the Cardiohelp device be FDA-cleared for children? Children who are receiving the Cardiohelp device will be approached and consented to participate if interested. Participants will undergo a standardized data collection to estimate survival to 30 days and the prevalence of serious adverse events like stroke, bleeding, and hemolysis. Outcomes will be compared to performance goals (PG) derived from the ECMO literature. Funding Source — FDA OOPD (Office of Orphan Products Development) |
CHRISTOPHER ALMOND; | 2025-04-15 |
| 39 | Prescription of Robotic Exoskeletons for Ambulation Recovery Post Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to evaluate and compare different robotic exoskeletons (RE) and identify which is most appropriate for gait training for each patient based off their specific needs. This will help guide clinicians in prescribing the appropriate RE for rehabilitation. |
KAREN J. NOLAN; | 2025-04-15 |
| 40 | Efficacy and Safety of Qingre Huatan Formula for The Prevention of Early Neurological Deterioration in Patients With Acute Ischemic Stroke : A Randomized Double-blind Placebo-controlled Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the effectiveness and safety of Qingre Huatan formula versus placebo on preventing early neurological deterioration in patients with acute ischemic stroke within 48 hours after onset. |
YING GAO; | 2025-04-15 |
| 41 | The Effect of Talocrural Joint Manipulation on Ankle Proprioception in Post-Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate the effect of talocrural joint manipulation on the ankle proprioception of patients with stroke. |
OMER DURSUN; | 2025-04-14 |
| 42 | Pill-in-Pocket Oral Anticoagulation Responding to Atrial Fibrillation Episodes Guided By Continuous Rhythm Monitoring and Automated Smartphone Alerts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia, affecting 1-2 million people in the UK. AF is characterised by uncoordinated electrical activation and ineffective contraction of the upper cardiac chambers. AF can occur in temporary episodes, as in paroxysmal AF, or can be sustained continuously beyond 7 days’ duration, as in persistent AF. The most significant potential complication of AF is stroke caused by a blood clot (thromboembolic stroke). If untreated, the risk of stroke in AF can be increased as much as five-fold, … |
TIM BETTS MD MBCHB FRCP; | 2025-04-14 |
| 43 | Remote Ischemic Conditioning for Acute Moderate Posterior Ischemic Stroke (RICAMIS2): A Prospective, Random, Open Label, Blinded End Point, Multi-center Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A substantial body of basic and clinical research has demonstrated the protective effects of remote ischemic conditioning (RIC) in ischemic stroke. While these clinical studies support the safety of RIC, the neuroprotective benefits of RIC in acute ischemic stroke (AIS) patients lack robust evidence due to small sample sizes, heterogeneous RIC protocols, and variability in the severity of neurological deficits among study populations. Our recent multicenter randomized clinical trial, the RICAMIS study, … |
HUI-SHENG CHEN; | 2025-04-13 |
| 44 | Effects of A Health Belief Model-Based Fall Prevention Education Program on Health Literacy and Physical Function in Patients with Chronic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to to evaluate the effects of a health belief model-based fall prevention education program on health literacy and physical function, fall rate, fall risk, fear of fall, and quality of life in patients with chronic stroke. The main question it aim to answer is \* Does a health belief model-based fall prevention education program have a positive effect on health literacy, physical function, fall risk, fear of falling, and quality of life in patients with chronic stroke? Researchers will compare the intervention group, … |
NUHA AWADH ALHARBI; | 2025-04-13 |
| 45 | Reduction of Edema With A Specialized Cocktail for Ultra-early Management in Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Large ischemic stroke is a severe subtype of acute ischemic stroke (AIS), often leading to malignant cerebral edema, elevated intracranial pressure, and poor functional outcomes. Despite early aggressive treatment, malignant cerebral edema remains a major determinant of prognosis, even in cases of successful recanalization. Preclinical studies suggest that a pharmacological cocktail (PPA) may alleviate cerebral edema by modulating extracellular potassium balance, maintaining aquaporin-4 expression, and enhancing lymphatic drainage. This multicenter, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-04-12 |
| 46 | Efficacy of Remote Ischemic Conditioning in Preventing Post-Stroke Depression: A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-stroke depression (PSD) is characterized primarily by low mood and loss of interest following a stroke. It is one of the most common and serious complications of stroke, with an incidence of 11% to 41% within two years post-stroke. PSD significantly impacts stroke prognosis, not only hindering neurological recovery but also increasing clinical disability and mortality rates, thereby imposing substantial economic and psychological burdens on families and society. Therefore, preventing PSD is crucial for stroke rehabilitation. Clinical trials have demonstrated that preventive antidepressant treatment can reduce PSD incidence and improve clinical outcomes; however, controversies remain regarding the timing, methods, … |
XUANWU HOSPITAL BEIJING | 2025-04-10 |
| 47 | The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Light is the most important regulator of circadian rhythm. Naturalistic light, which contains the spectrum of sunlight throughout the day, has been shown to have a positive impact on mental states such as depression and fatigue in stroke and other diseases requiring long-term hospitalization. Depression and fatigue are very common complications after stroke, with a frequency of 30% and 85%, respectively. Both are significantly related to reduced quality of life and early death. Both the causes and pathophysiology behind these complications are unknown, … |
ANDERS SODE WEST; | 2025-04-10 |
| 48 | Effects of Neurocognitive Therapy With and Without Soft Robotic Hand on Hand Function in Sub-acute Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effect of neurocognitive therapy with and without a soft robotic hand on manual ability, dexterity, strength, spasticity and upper limb function in sub-acute stroke. |
ARUBA SAEED; | 2025-04-10 |
| 49 | Effects of Otago Exercise Program Combined With Action Observation Training on Balance, Gait and Functional Activities in Post Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is one of the main causes of adult disability worldwide and global health problem. Due to ongoing neurological sequelae post stroke patients have a two-fold higher risk of falling than other people with same age or gender. As the stroke patients, balance is impaired and can lead to complications such as fall. Promising interventions that could be beneficial to improve the aspects of gait and balance include Otago exercises and Action observation training. The objective of this study is to determine the effects of Otago exercise combined with Action observation (AO) training on the balance, … |
ARUBA SAEED; | 2025-04-10 |
| 50 | Comparative Effects of Unstable Surfaces and Bobath Based Trunk Exercises on Trunk Impairment, Postural Control and Balance in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is an acute, focal neurological deficit attributed to vascular injury (infarction, hemorrhage) of the central nervous system. Trunk control, balance and posture are often impaired after stroke. Trunk and lower limb balance are vital for stroke patients as they significantly impact their functional independence, mobility, and safety. Training on unstable surfaces enhances core strength, balance, coordination, and proprioception. Bobath approach emphasizes the use of controlled, functional movements to enhance postural control and stability. This study aims to determine the comparative effectiveness of trunk training on unstable surfaces and bobath approach on trunk impairment, … |
ARUBA SAEED; | 2025-04-10 |
| 51 | Combined Effects of Segmental Vibrator With Neuromuscular Electrical Stimulation for Dorsiflexors on Lower Limb Function in Subacute Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is one of the world’s leading causes of death and disability. It can cause a variety of motor disorders, such as apraxia, sensory deficits, abnormal muscle tone, inadequate weight transfer, lack of fine motor skills, incoordination, and balance deficit. These disorders can have a significant negative impact on a person’s quality of life. |
ARUBA SAEED; | 2025-04-10 |
| 52 | Pharmacogenomics in Stroke: Feasibility of CYP2C19 Testing in Patients With Minor Stroke or High Risk TIA (CYP2C19 and Stroke) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to explore whether genetic testing can offer a personalized and timely approach to assist physicians in making more informed medication decisions for stroke or high-risk transient ischemic attack (TIA) patients during their hospital stay. |
EKATERINA BAKRADZE; | 2025-04-09 |
| 53 | Motor-Cognitive Interactive Upper Limb Rehabilitation Robot Intervention for Post-Stroke Motor Dysfunction: A Multicenter Randomized Controlled Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the effects of motor-cognitive interactive robot-assisted training on improving upper limb motor dysfunction after stroke. By observing different combinations of motor and cognitive components in the training, the study will clarify the relationship between the proportion of motor and cognitive elements and the recovery of upper limb motor function. The goal is to optimize the training protocol for upper limb rehabilitation robots and enhance their therapeutic outcomes. Participants will be randomly assigned to one of three groups: motor-cognitive interactive robot-assisted training, motor-focused robot-assisted training, or conventional rehabilitation training. Training sessions will last 60 minutes, … |
LIDIAN CHEN; | 2025-04-08 |
| 54 | Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Acute Intracerebral Hemorrhage PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with acute intracerebral hemorrhage (ICH). The taVNS intervention will be delivered using the BS-TVNS800-1 transcutaneous electrical stimulation therapy device (KERFUN, Shanxi, China). A total of 186 patients will be randomly assigned in a 1:1 ratio to either the taVNS group or the sham-taVNS group. The primary outcome is the relative volume of perihematoma edema assessed on day 10-14 after randomization. Adverse events associated with taVNS therapy will be systematically evaluated to assess its safety profile. |
KAIJIANG KANG; | 2025-04-08 |
| 55 | Effects of Functional Massage Combined With Eccentric Exercise on Muscle Tone and Motor Function of The Lower Limb in Patients With Chronic Stroke: A Pilot Randomized Clinical Trial Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is currently the leading cause of mortality in women, the second in men and the leading cause of disability in older adults. One of the most challenging sequelae after stroke is increased muscle tone due to spasticity, which alters muscle function. Functional massage therapy focuses on enhancing the function of muscles, joints, and connective tissues to improve movement and reduce pain. On the other hand, eccentric exercise, … |
ROSA CABANAS VALDÉS; | 2025-04-05 |
| 56 | Activity-based Mirror Therapy for Lower Limb Motor Recovery, Balance, Gait, and Mobility in Acute Inpatient Stroke: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This feasibility study is the first step of a larger effects study exploring the use of an activity-based mirror therapy program for people who have had a stroke in the last 30 days and are in the hospital. The study aims to examine features of the study design as well as the preliminary effects of the mirror therapy program on motor recovery, balance, gait, and mobility. In this study participants will complete 15 minutes of lower limb mirror therapy three days per week for two weeks, alongside their usual physiotherapy. The motor recovery, balance, gait, … |
VICKY JOSHI; | 2025-04-04 |
| 57 | Effect of TAVNS Application on Respiratory Functions in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation (TAVSS) in improving respiratory muscle strength and function in chronic stroke patients. It aims to explore TAVSS as a potential complementary approach in enhancing rehabilitation outcomes for this population. |
BURCU AKKURT; | 2025-04-02 |
| 58 | A Randomized Clinical Trial Investigating The Impact of Artificial Intelligence Electrocardiography on Occlusion Myocardial Infarction Management Under The Value-Based Payment System PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial will prospectively evaluate the impact of integrating AI-ECG within the pay-for-performance program on improving the diagnosis, treatment, and clinical outcomes of occlusion myocardial infarction patients by promoting accurate and timely diagnoses through financial incentives. |
CHIN LIN; | 2025-04-01 |
| 59 | Individualized Temperature Health Risk Early Warning and Risk Factor Management App for Reducing The Recurrence Risk of Stroke: A Multicenter, Randomized Controlled Trial Study PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This study employs individualized temperature health risk early warning and risk factor management interventions for stroke, and explores their actual intervention effects. This enables patients to promptly understand their own risk levels and take corresponding protective measures, thereby enhancing the management outcomes and quality of life. The study also promotes the interdisciplinary integration of environmental epidemiology and clinical intervention management, providing new ideas and methodological support for future relevant research. |
XUANWU HOSPITAL BEIJING | 2025-04-01 |
| 60 | Precision Antiplatelet Therapy Guided By Platelet Aggregation Function in Patients with Acute Ischemic STROKE PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this clinical trial is to evaluate the efficacy and safety of platelet aggregation function – guided precision anti – platelet therapy in patients with acute cerebral infarction. The main question it aims to answer is: among the cerebral infarction patients with possible clopidogrel resistance detected by platelet aggregation function tests, what is the efficacy and safety of using ticagrelor to replace the clopidogrel treatment regimen. |
JIE YANG; | 2025-04-01 |
| 61 | Further Lipid-Lowering With PCSK9 Inhibitors for Cardiovascular Outcomes in High-Risk Coronary Plaques Assessed By CT Angiography PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective was to evaluate the effect of PCSK9 inhibitors in addition to the background lipid-modifying therapy (LMT), compared with placebo plus background LMT in terms of clinical outcomes in patients with coronary CT angiography (CCTA)-detected high-risk plaques. |
XINYANG HU; | 2025-04-01 |
| 62 | Methylprednisolone With Endovascular Thrombectomy for Large Ischemic Stroke (MATCH): A Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: It is uncertain whether intravenous methylprednisolone improves outcomes for acute anterior circulation large vascular occlusion (LVO) patients with a large infarct core. In this study, the investigators assume that methylprednisolone plus endovascular thrombectomy (EVT) might be superior to EVT alone for patients who have evidence of a large infarct volume. The objective of the study was to establish the efficacy and safety of methylprednisolone with EVT in patients presenting with symptoms of acute ischemic stroke from LVO in the anterior circulation and having a large infarct volume. |
QINGYU SHEN; | 2025-04-01 |
| 63 | Discontinuation of Antiplatelet Agent After Drug-Coated Balloon Angioplasty in Stabilized Patients With High Bleeding Risk and Coronary Artery Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, multi-center, open-label, randomized controlled, and superiority trial. The trial will compare clinical outcomes between discontinuation of antiplatelet agent and continuation of antiplatelet agent in HBR patients with chronic coronary syndrome treated by DCB angioplasty and standard duration of DAPT, followed by maintenance of single antiplatelet agent without clinical event for at least 1 year from the index procedure. |
JOO MYUNG LEE; | 2025-04-01 |
| 64 | A Multicenter, Double-Blind, Randomized Controlled Study on The Impact of Tongmai Jiangtang Capsules on The Risk of Cardiovascular and Cerebrovascular Events in Metabolic Syndrome PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Conduct a large-sample, multicenter, superiority, double-blind, randomized controlled clinical trial to verify the efficacy of TJC in reducing the risk of cardiovascular and cerebrovascular events in patients with metabolic syndrome at high cardiovascular and cerebrovascular risk (HCR-MS). 2. Further construct an evaluation system for the long-term cardiovascular and cerebrovascular benefits of traditional Chinese medicine in regulating glucose and lipid metabolism through the evaluative study of the cardiovascular and cerebrovascular benefits of TJC. |
ZHENJIE LIU; | 2025-04-01 |
| 65 | Rapid Evacuation and Access of Cerebral Hemorrhage Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care. The standard treatment involves admission to the Intensive Care Unit (ICU) with close monitoring and blood pressure control. It also includes other medical (non-surgical) treatments to prevent more bleeding or another stroke. Sometimes, … |
ALEX HALL; | 2025-04-01 |
| 66 | ROOMMATE – AggRegated System of SensOrs and Multimedia Monitors: Technology for InnovAtion and PersonalizaTion of REhabilitation Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to assess whether the ROOMMATE system can effectively support the rehabilitation of adults recovering from subacute strokes. The study will be conducted at the neuromotor rehabilitation inpatient clinics of IRCCS Fondazione Don Carlo Gnocchi in Florence, Italy, and the rehabilitation inpatient unit of Elias University Emergency Hospital in Bucharest, Romania. Primary Objectives: -To assess the effects on functional recovery in subacute stroke survivors of a technological rehabilitation station placed at patients’ bedsides, combined with dedicated coaching provided to all users (patients, informal caregivers, … |
FRANCESCA CECCHI; | 2025-04-01 |
| 67 | Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to * to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; * to evaluate the influence of lesion location on autonomic dysfunction; * to identify patterns of structural and functional brain connectivity within the central autonomic control circuits associated with autonomic dysfunction; and * to explore causal models of the link between brain lesions; cardiac, immunological and endocrine biomarkers; … |
ECKHARD SCHLEMM; | 2025-04-01 |
| 68 | Application of Wearable ECG Garments in Atrial Fibrillation Screening and Stroke Risk Assessment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the application of wearable ECG garments in atrial fibrillation (AF) screening and stroke risk assessment. Using a prospective, multicenter, observational design, the study will recruit high-risk stroke patients aged 40 and above to undergo 24-hour continuous ECG monitoring with wearable ECG garments. The study will assess the detection rate of AF and explore the correlation between heart rate variability (HRV) parameters and stroke risk. Additionally, the study will analyze the association between P-wave indices and AF, … |
YATING WU; | 2025-04-01 |
| 69 | Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Motor and Cognitive Deficits After Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if transcutaneous auricular vagus nerve stimulation (taVNS) works to treat motor and neurocognitive deficits after ischemic stroke when applied within 30 days after onset of stroke. The main questions it aims to answer are: * Does tVNS improve motor deficits measured by the Fugl-Mayer assessment after ischemic stroke? * Does tVNS ameliorate stroke-related cognitive impairment? Researchers will compare tVNS to a placebo (sham stimulation, … |
RHEINBURG KLINIK | 2025-04-01 |
| 70 | Behavioral Activation for The PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors (LIVE-WEL) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall objective of the project is to determine the effectiveness of tele-delivered behavioral activation (BA) by trained lay counselors (Tele-BA-S) to prevent Post-stroke depression (PSD) in low-income, older stroke survivors with subthreshold depression (SD). |
JENNIFER BEAUCHAMP; | 2025-04-01 |
| 71 | The Application of Kinesio Taping Technique in The Early Upper Limb Functional Activities Induction of Hemiplegic Patients After Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To observe the inducing and promoting effect of kinesio taping technique on the recovery of upper limb function in early-stage stroke patients. 2. To compare the different effects of kinesio tape and sports white tape on the induction and promotion of limb function in patients. 3. To verify that kinesio taping technique is a safe and promotable technical means for stroke patients. |
THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE | 2025-04-01 |
| 72 | A Space-expanding Shield in Decompressive Hemicraniectomy for Stroke – A Randomized-controlled Multicenter Phase III Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Instead of the standard decompressive hemicraniectomy with subsequent cranioplasty a single surgery with the implantation of an individually molded space-expanding shield is investigated in for patients with increased intracranial pressure due to a malignant stroke. |
SCHUCHT PHILIPPE; | 2025-04-01 |
| 73 | Low-Dose Edoxaban Versus Very-Low-Dose Edoxaban in Elderly Patients With Atrial Fibrillation and A History of Stroke (LEAVE-Stroke): A Pragmatic Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospectively enrolled, pragmatic randomized trial aims to investigate whether very low dose edoxaban regimen (15 mg daily) achieves similar edoxaban concentrations as low dose edoxaban regimen (30 mg daily), while maintaining a comparable risk of clinical outcomes and reducing major bleeding in elderly patients with atrial fibrillation and a history of ischemic stroke or transient ischemic attack. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2025-04-01 |
| 74 | GENETIC VARIANTS of ANNEXIN A2 and CRYPTOGENIC STROKE PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is the third most common cause of death in developed countries. Various mechanisms of ischemic stroke exist. However, in young population, in a third of cases, the cause of a stroke cannot be determined despite an extensive evaluation. Many studies have highlighted the link between stroke and fibrinolysis. Genetic variants of tPA and PAI-1 genes have been suggested to be the risk factors for stroke. ANXA2 plays a pivotal role in plasmin generation and fibrinolysis. Several studies showed the role of ANXA2 and S100A10 subunits in regulation of fibrinolysis in vivo. Recently, … |
CENTRE HOSPITALIER UNIVERSITAIRE AMIENS | 2025-04-01 |
| 75 | Effects of Physiological Manipulation and Surface Electrical Stimulation Towards Safe Swallowing in Post Stroke Dysphagia Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dysphagia is common diagnosed problem after stroke in geriatric population. Digestive system is one of the key systems of human body in which the ingested food is broken down, … |
NAZIA MUMTAZ; | 2025-04-01 |
| 76 | Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research will explore if brain stimulation combined with virtual reality therapy improves visual impairment. The stimulation technique is called low-intensity focused ultrasound stimulation (LIFUS). The treatment uses ultrasound to stimulate vision specific parts of the brain. Before this therapy, … |
DUKE UNIVERSITY | 2025-04-01 |
| 77 | Collaborative Development of A Virtual Reality Scenario, Integrated Into A Robotic Upper Limb Rehabilitation Device, for The Treatment of Unilateral Spatial Negligence (NSU) Through Mutisensory Stimulation: Feasibility and Usability Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot clinical trial is to develop an integrated motor and cognitive rehabilitation program and evaluate the usability and acceptability of a new virtual reality scenario designed for the MOTORE device. This study will focus on the rehabilitation of the upper limbs in post-stroke patients with plegia and left-sided hemi-inattention. The main questions it aims to answer are: * The evaluation of the usability and acceptability of the newly developed scenario * The evaluation of the effects of the new scenario on patients’ hemi-inattention * The evaluation of changes in upper limb functional parameters Participants will undergo a total of 13 rehabilitation sessions, each lasting 45 minutes, using the new scenario, including an initial and final assessment. |
FONDAZIONE DON CARLO GNOCCHI ONLUS | 2025-04-01 |
| 78 | De-Implementation of Low-value Testing in Patients Undergoing Low-Risk Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial aims to evaluate the effectiveness of a multi-level, multi-component de-implementation strategy to reduce unnecessary preoperative testing. Sixteen Michigan Value Collaborative (MVC)/Michigan Surgical Quality Collaborative (MSQC) sites in Michigan will implement several tools that have been proven to reduce unnecessary testing at a single site, including clinician education, a decision aid, audit and feedback on performance, and a pay-for-performance incentive. The researchers believe that, through the use of these strategies, there will be a significant reduction in unnecessary preoperative testing during the intervention. |
LESLY ANN DOSSETT; | 2025-04-01 |
| 79 | EFFECTIVENESS of TRANSCUTANEOUS AURICULAR VAGUS NERVE STIMULATION on UPPER LIMB MOTOR RECOVERY AFTER STORKE PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effects of transcutaneous vagus nerve stimulation in combination with physical rehabilitation on upper limb motor function of patients with stroke. |
FUNDACIÓN CARDIOVASCULAR DE COLOMBIA | 2025-04-01 |
| 80 | First In Human Clinical Study of The CorWave Left Ventricular Assist System for The Treatment of Patients With Advanced Heart Failure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a prospective, multi-center, non-randomized trial to evaluate the safety and effectiveness of the CorWave LVAD for the treatment of advanced heart failure patients. |
CORWAVE | 2025-04-01 |
| 81 | Investigating The Impact of ITBS Stimulation on Various Brain Regions on The HPA Axis in Stroke Patients Using Resting-State EEG Data PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The project team will categorize stroke patients into three groups receiving iTBS stimulation targeting distinct brain regions: the cerebellum, the dorsolateral prefrontal cortex (DLPFC), and the primary motor cortex (M1), with 20 patients allocated to each group. Neurofunctional scores, anxiety and depression assessments, and transcranial magnetic stimulation evoked potentials (TEP) will be assessed pre- and post-treatment within each group. The relationship between anxiety and depression scores and brain network characteristics associated with emotions will be examined to investigate the impact of iTBS stimulation on post-stroke negative emotions. Furthermore, … |
LIQING YAO; | 2025-04-01 |
| 82 | Evaluation of 3 Patterned RTMS Stimulation Dosage on Corticospinal Excitability and Motor Learning in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better. |
WUWEI FENG; | 2025-04-01 |
| 83 | The Effectiveness of Moderate-vigorous Intermittent Lifestyle Physical Activity and Health Education to Increase Intense Physical Activity in Stroke Survivors: A Pragmatic Randomised Controlled Trial (MV-ILPA-stroke) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is the leading cause of disability in Spain. Additionally, it is the second leading cause of death in women and the third in both sexes. Regular physical activity (PA) helps prevent and manage stroke. It also helps with hypertension, maintains a healthy body weight, and improves mental health, quality of life, and well-being. PA plays a prominent role in inpatient care after stroke. However, stroke survivors become more sedentary when discharged from the hospital. They have muscle weakness, reduced balance, and fatigue. Consequently, … |
ROSA CABANAS VALDÉS; | 2025-04-01 |
| 84 | A Study to Evaluate The Safety, Tolerability and Pharmacokinetics of HRS-4029 Following A Single Dose in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being conducted to evaluate the safety, tolerability and pharmacokinetics of HRS-4029 following a single intravenous dose administration in healthy subjects. |
JINTONG LI; | 2025-04-01 |
| 85 | Facilitating Neuroplastic Changes of Acute Stroke Survivors With Severe Hemiplegia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-stroke including patients who are paralyzed with no motor output. The early acute stroke rehabilitation device will be evaluated in this clinical trial. |
LI-QUN ZHANG; | 2025-04-01 |
| 86 | Centering Emotional Recovery Post-Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate whether adding an emotional wellness component to occupational therapy (OT) and/or speech therapy (ST) telerehabilitation improves overall emotional well-being and activity participation for people with stroke. |
MICHELLE WOODBURY; | 2025-04-01 |
| 87 | MagNETs- Managing Transient Neurologic Episodes in Surgery for Moyamoya Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to study the incidence of post-operative Transient Neurologic Events (TNEs) within 30 days postoperatively, as assessed by clinical neurological scales, binned by week. Collect data on all interventions and assessments performed during the recovery post surgery up to 30 days, to understand what factors might cause Transient Neurologic Events (TNEs) and determine how these can be reduced in Moyamoya subjects post surgery. |
GARY STEINBERG; | 2025-04-01 |
| 88 | Individualized Exercise Prescription with A Data-driven Approach in Individuals with Stroke – A Feasible Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate if the exercised via data-driven approach is effective in enhance the gait pattern in people with stroke. It will reduce burdun of patient consultations for clinicians in reality.The main questions it aims to answer are: Does individualized exercise training programmes via data-driven approach could improve gait patterns in individuals with chronic stroke? Does individualized exercise training programmes via data-driven approach could improve improve motor recovery, motor functions (including gait speed and balance performance), and community integration in individuals with chronic stroke? Participants will: Undergo 12 supervised-exercise (training sessions (60 minutes, … |
PATRICK KWONG; | 2025-04-01 |
| 89 | Innovative Upper Limb Stroke Rehabilitation Approach Combining Myoelectric Control Assistance in Virtual Reality and Cerebellar TBS Plasticity Enhancement PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators hypothesize that a myoelectric (EMG) controlled VR interface allows for effective upper limb motor recovery of stroke patients. EMG control offers the possibility to alter visual feedback according to the recorded muscle activity in real-time. By manipulating the motion of a virtual hand associated with the recorded muscle patterns, assistance can be provided to stroke patients by correcting the error between the actual (dysfunctional) and a reference (functional) muscle pattern. Thus, through such an assistive EMG control algorithm, patients will be able to perform reaching movements with the virtual hand despite their motor impairment. By gradually reducing assistance, … |
I R C C S FONDAZIONE SANTA LUCIA | 2025-04-01 |
| 90 | COMBINED EFFECTS OF FOCAL MUSCLE VIBRATION AND TDCS ON MOTOR RECOVERY IN STROKE PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Although tDCS and FV have shown some benefit as stand-alone treatment, researcher suggest that combining intervention with complementary mechanism can lead to additive or synergistic benefits which might yield more significant improvement in functional outcome hence the author propose to plan the combination of FV with tDCS for motor recovery /spasticity in stroke patients. |
MIRZA OBAID BAIG; | 2025-04-01 |
| 91 | Effects of Inspiratory Muscle Training on Respiratory and Diaphragmatic Functions, Balance Control, Exercise Capacity and Quality of Life in People After Stroke: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled trial. This current RCT study will be a continuing project based on the optimal IMT intensity identified from our ongoing study. This ongoing study (registered on ClinicalTrials.gov with the registration number NCT06267768) aims to explore the optimal IMT intensity for the recruitment of diaphragm muscles in people after a stroke. Based on this intensity, the aim of this RCT is to explore the effects of a 4-week protocol of IMT on respiratory function, balance control, exercise capacity, and quality of life in people after a stroke. |
LIU FANG; | 2025-04-01 |
| 92 | A Trial of Rehabilitation Paired with VNS for Motor Function Recovery in Post-ICH Patients (Recovery Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the efficacy and safety of vagus nerve stimulation (VNS) combined with rehabilitation in improving upper extremity motor function after spontaneous intracerebral hemorrhage (ICH). Researchers will evaluate the efficacy and safety of VNS by comparing the improvements of arm motor function post-ICH in the active VNS combined rehabilitation group with that in the sham VNS combined rehabilitation group (actual intensity 0 mA). Participants in this study will undergo a surgical procedure to implant the VNS system and will subsequently recieve a 6 weeks in-clinic therapy, … |
DE-ZHI KANG; | 2025-04-01 |
| 93 | Influence of Sensory Electrical Stimulation on Hand Functions in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the impact of sensory electrical nerve stimulation (SENS) on hand function in chronic stroke patients. Thirty participants were randomly divided into two groups: Study Group (A): Received SENS combined with task-specific training. Control Group (B): Received only task-specific training. Assessments conducted before and after the intervention included measurements of grip strength, pinch strength, wrist range of motion, and performance on the Action Research Arm Test (ARAT). |
ISLAM HASSAN FAYED; | 2025-04-01 |
| 94 | EFFECT OF INSPIRATORY MUSCLE TRAINER ON AUTONOMIC MODULATION AND PULMONARY FUNCTION IN PATIENTS WITH STROKE PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke individuals with hemiplegia often display difficulties in mobility, cardiopulmonary function…etc. All stroke patients had restrictive pulmonary dysfunction. Therefore, respiratory training improves their respiratory capacity, and orthostatic stress mediated respiratory, cardiovascular and autonomic response. Respiratory muscle training interventions are efficient in terms of pulmonary functional parameters. In advanced line, this study will be conducted to evaluate inspiratory muscle trainer effect on autonomic modulation and pulmonary function in stroke patients. |
ADLY A ADAM; | 2025-04-01 |
| 95 | Effectiveness of A Therapeutic Exercise Program Combined With Respiratory Muscle Training in Patients With Subacute Stroke: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke has a significant impact on morbidity, mortality and healthcare expenditure globally. In addition to the motor and cognitive consequences, as well as on functional independence and social participation, it can produce alterations in the respiratory function. Scientific evidence supports the application of both therapeutic exercise programs and respiratory muscle training (RMT). However, studies that combine both interventions are limited, and to date no study has been published that examines the effectiveness of this combination in the subacute phase of stroke, … |
ANA LISTA PAZ; | 2025-04-01 |
| 96 | Allopregnanolone in Post-Stroke Depression Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this Phase II clinical trial is to learn if the oral synthetic allopreganolone analog (zuranolone) is safe to take and is well tolerated by stroke survivors experiencing moderate to severe post-stroke depression and if it will help with the symptoms of depression. The main questions it will aim to answer are: * Is zuranolone safe to take by participants who have moderate to severe post-stroke depression? * Is zuranolone well-tolerated by participants who have moderate to severe post-stroke depression? * Does zuranolone treat moderate to severe post-stroke depression? The study will enroll six participants. All participants will be given 50 mg of zuranolone for 14 days. Participants will be asked to provide blood samples, complete some questionnaires including those related to mood and a cognitive assessment. |
NADA EL HUSSEINI; | 2025-04-01 |
| 97 | Ultrathin Strut Sirolimus-eluting Stent With Bioabsorbable Polymer in Patients Receiving Chronic Oral Anticoagulation PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients receiving chronic oral anticoagulation with indication for percutaneous coronary revascularization with stent implantation, and needing for antiplatelet therapy, are at high risk of bleeding. The new generation of ultrathin strut sirolimus-eluting stent with bioabsorbable polymer allow for shorter antiplatelets regimens and could be a good option for this high-bleeding risk patients. |
FUNDACIÓN EPIC | 2025-03-31 |
| 98 | Direct Ischemic Conditioning for Endovascular Recanalization for Anterior Large Vessel Occlusion (DICER-aLVO): A Prospective, Randomized, Open Label, Blinded-end Point, Phase 2, Multi-centre Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute ischemic stroke (AIS) is the most common type of stroke, with high incidence rate and mortality. Endovascular therapy is currently the most effective treatment for AIS with large vessel occlusion, but only about 50% of patients achieve good outcome after endovascular therapy, while 50% of patients have poor prognosis, commonly referred to as ineffective perfusion. Therefore, … |
HUI-SHENG CHEN; | 2025-03-31 |
| 99 | IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting – A Pragmatic, International, Multicentre, Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this international, multi-center, randomized clinical trial is to compare two treatment options, early intracranial stenting and continued stent-retriever or aspiration based endovascular treatment, for stroke patients with a large vessel occlusion, who experienced failure of recanalisation after initial treatment due to intracranial atherosclerosis. |
MARIOS-NIKOS PSYCHOGIOS; | 2025-03-31 |
| 100 | Heart Evaluation of Acute Ischemic Stroke with Reperfusion Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart Evaluation of Acute ischemic stroke with Reperfusion Therapy (HEART) is a single-center observational registry evaluating the heart of patients hospitalized for acute ischemic stroke with reperfusion therapy. This registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies. |
JIANQIANG NI; | 2025-03-31 |
| 101 | A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral TTI-0102 for Treatment of Patients with Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, placebo-controlled study. Prior to treatment, patients will undergo a screening visit. If eligible, each subject will return for a Day 1 visit and will receive their first dose of investigational product (TTI-0102 or placebo). At the end of the first week of treatment, subjects will return for a Week 1/Day 8 study visit to assess study drug dosing/tolerance and instruct on dosing for the upcoming second week of treatment. For the first 8 weeks of treatment, … |
THIOGENESIS THERAPEUTICS | 2025-03-31 |
| 102 | Unilateral and Bilateral Approaches to Robotic Therapy Hybridized With Mirror Therapy in Stroke Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effects of three groups: (1) unilateral robotic therapy with computerized visual feedback plus unilateral innovative mirror therapy, (2) bilateral robotic therapy with computerized visual feedback plus bilateral innovative mirror therapy, and (3) dose-matched conventional rehabilitation as the control. The investigators will also study the factors predictive of treatment success, identify key predictors of clinical improvement, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2025-03-31 |
| 103 | CANTO – Cell-free DNA in Acute Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cell-free DNA (cfDNA) is an important pro-inflammatory and prothrombotic mediator. With this study the investigators aim to gain new insights into the role of cfDNA in stroke and to perform a combined analysis of cfDNA in the hyperacute phase of the disease using blood and thrombus analyses. The main objectives are to analyse cfDNA in different stroke etiologies, to investigate the relationship between cfDNA and important procedural factors such as secondary embolisation and reperfusion outcomes, to analyse the correlation between blood and thrombus content of cfDNA and to investigate the specific source of cfDNA in distinct stroke subtypes. |
GERRIT GROSSE; | 2025-03-30 |
| 104 | Feasibility and Efficacy of PRO-MAMA – A Novel Occupational Therapy Intervention for Promoting Participation, Health and Wellbeing Among Older Mothers After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This experimental design will assess the feasibility \& initial effectiveness of PRO-MAMAS (promoting participation, health and wellbeing through meaningful maternal-role activities after stroke) – a novel occupational therapy intervention program to promote participation, health and wellbeing of older mothers with chronic stroke. Assessments will be conducted at three time points: baseline, pre, post the Pro-MAMA intervention |
DEBBIE RAND; | 2025-03-30 |
| 105 | Quantifying and Treating Myofascial Dysfunction in Post Stroke Shoulder Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Shoulder pain is extremely common after stroke and occurs in 30-70% of patients. The pain may begin as early as one week after stroke, although peak onset and severity occurs around four months, and persists into the chronic stage. Chronic post stroke shoulder pain (PSSP) interferes with motor recovery, decreases quality of life, and contributes to depression. PSSP is thought to be caused mainly by damage to the myofascial tissues around the shoulder joint. Interestingly, … |
NING CAO; | 2025-03-28 |
| 106 | The Pivotal Study of RapidPulseTM Aspiration System As Frontline Approach for Patient With Acute Ischemic Stroke Due to Large Vessel Occlusions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trials is to demonstrate the safety and effectiveness for the RapidPulseTM Aspiration System in patients experiencing acute ischemic stroke within 8 hours of symptom onset or last seen normal. Subjects will undergo mechanical thrombectomy (a procedure to remove a clot in the brain which is preventing blood flow), with the RapidPulseTM Aspiration System. Participation in the trial is for 90 days. |
RAUL G NOGUEIRA; | 2025-03-27 |
| 107 | Efficacy and Sustainability of A Carepartner-Integrated Telerehabilitation Program for Persons With Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a leading cause of long-term disability. Research has placed little emphasis on integrating care partners (CP) (family members) into the rehabilitation process without increasing negative care partner outcomes. The research team has developed and implemented a novel, web-based care partner-focused intervention (CARE-CITE) designed to foster problem-solving and skill building while facilitating care partner engagement during stroke survivor (SS) upper extremity practice of daily activities in the home setting. By providing a family-focused approach to rehabilitation interventions, this project will help develop more effective treatments that improve CP and outcomes after stroke. |
SARAH BLANTON; | 2025-03-25 |
| 108 | Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for The Management of Equinovarus Foot Deformity in Patients with Refractory Lower Limb Spasticity After Stroke: A Multicenter, Randomized Controlled, Non-inferiority Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: CRYOSTROKE study is designed : * to compare the efficacy and safety of percutaneous CryoNeurotomie (CN) versus surgical neurotomy (SN) on spasticity, 90 days after intervention, in post-stroke patients presenting with spastic equinovarus foot and, * to ensure that potential clinical effect/safety remain stable within time, with a 12-month follow-up. |
POITIERS UNIVERSITY HOSPITAL | 2025-03-25 |
| 109 | Robot-Assisted Tai Chi for Upper Limb Rehabilitation in Post-Stroke Patients: A Randomized Controlled Trial on Motor Recovery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare the effectiveness of Robot-Assisted Tai Chi Training (RATT) versus conventional rehabilitation in improving upper limb motor function post-stroke, and to explore the neuromuscular mechanisms of RATT. Participants will be randomly assigned to one of two groups: 1. Robot-Assisted Tai Chi Training group: Participants will receive guided Tai Chi arm movements with robotic assistance to enhance coordination and strength. 2. Conventional rehabilitation group: Participants will perform standard exercises (e.g., stretching, repetitive task practice). Both groups will receive 60-minute sessions, administered 5 days a week, over 4 weeks. Researchers will measure improvements using clinical scales (e.g., … |
JING TAO; | 2025-03-24 |
| 110 | Effect of Inspiratory Muscle Training Combined With Abdominal Drawing-In Maneuver on Balance, Gait, and Pulmonary Function in Subacute Stroke Patients: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines how Inspiratory Muscle Training (IMT) combined with the Abdominal Drawing-In Maneuver (ADIM) affects balance, gait, and breathing in stroke patients. It aims to determine whether this combined intervention improves mobility and respiratory function more effectively than standard rehabilitation. |
DOHYOUNG KIM; | 2025-03-24 |
| 111 | Health Effects of Vitamin K2 and Zinc Supplementation on Skeletal Muscle and Neurological Function After Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of this clinical trial is to assess whether vitamin K2 or zinc supplementation can effectively improve skeletal muscle and neurological function in patients with ischemic stroke. The main questions it aims to answer are: 1. Does supplementation with vitamin K2 or zinc improve the subjects’ muscle strength and muscle mass? 2. Can supplementation with vitamin K2 or zinc improve the subjects’ neurological function after a stroke? Researchers will compare vitamin K2 or zinc supplements with a placebo to observe whether vitamin K2 or zinc supplementation can improve skeletal muscle and neurological function in patients with ischemic stroke. Participants will: 1. Take vitamin K2 (MK-7), zinc supplements, or a placebo daily for 2 years. 2. Attend face-to-face visits and provide biological samples and relevant data at 0, 3, 6, 9, 12, and 24 months (intervention phase). After the intervention, follow-up will continue for 1 year to observe the long-term effects. |
YING LI; | 2025-03-23 |
| 112 | Effectiveness and Safety of Intracardiac Echocardiography-Guided Catheter Ablation for Premature Ventricular Contractions Originating From The Papillary Muscles: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized, prospective, parallel, single-blind, multicenter clinical trial investigates the efficacy and safety of intracardiac echocardiography (ICE)-guided catheter ablation versus pressure-sensing catheter ablation alone in reducing PVC recurrence among patients with confirmed papillary muscle-originating premature ventricular contractions (PVCs). Participants were randomly allocated to either the ICE-guided intervention group or the conventional ablation control group following definitive diagnosis. |
XU LIU; | 2025-03-23 |
| 113 | Carotid Endarterectomy and Stenting Timing：The CEST Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the safety and efficacy of carotid revascularization performed within 48 hours versus after 14 days in patients with symptomatic carotid stenosis accompanied with MRI-confirmed acute infarction (high signal on diffusion-weighted imaging accompanied by low apparent diffusion coefficient signal) in the responsible vascular territory. |
XUANWU HOSPITAL BEIJING | 2025-03-22 |
| 114 | Minimal Clinically Important Difference (MCID) of Clinical Test of Sensory Interaction on Balance (CTSIB) in Individuals With Sub-Acute Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a major cause of disability worldwide, often leading to balance impairments due to deficits in sensory integration and motor control. These impairments hinder postural stability and functional independence, making balance rehabilitation a critical focus in sub-acute stroke care. |
MUHAMMAD NAVEED BABUR; | 2025-03-20 |
| 115 | The Effect of Wearing Customized Insole on Foot Alignment, Body Alignment, and Balance Ability in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Goal: This study will be conducted to find out the effects of customized insole on foot alignment, body alignment, and balance ability of stroke patients. Recruitment: Total 20 participants will be recruited and will be divided into 2 groups: Intervention and control group with or without wearing foot insole for 6 weeks. Evaluation tool: 1. MediACE Scanner-MS320F will be used to evaluate foot alignment and will create customized insole. 2. Exbody 770 will be used to measure body alignment. 3. Timed up \& go test will be used to evaluate dynamic balance. Intervention: The intervention group will wear a customized insole during daily life for 6 weeks whereas the control group will not. Evaluation will be conducted 2 times before and after 6 weeks. |
MEEYOUNG KIM; | 2025-03-20 |
| 116 | Comparative Effect of Vojta Therapy and Bobath Therapy on Lower Limb Spasticity and Motorcity Among Hemiparetic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Stroke is clinical defined as a neurological syndrome characterized by acute disruption of blood flow to an area of brain and corresponding onset of neurological defects related to the concerned area of brain. Hemiplegic patient primarily affects the upper limb and lower limb of one side and typically results in flaccidity and difficulties with motor control and function. |
MUHAMMAD NAVEED BABUR; | 2025-03-20 |
| 117 | The Effects of Home-based Graded Repetitive Arm Supplementary Program Group on Stroke: The Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Graded repetitive arm supplementary program (GRASP) is a self administrated, home-based rehabilitation program and has been incorporated in Canadian Stroke Best Practice Recommendations. Past studies indicated that the home-based GRASP program could facilitate the motor function and motor recovery and prevent learned nonuse of affected upper limb of stroke patients. There is lacking of research and application of the home-based GRASP program in Taiwan. Therefore, this study aims to explore the effects of the home-based GRASP program, which is mainly executed in the form of group intervention, on the affected upper limb of stroke patients. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2025-03-17 |
| 118 | A New At-home Telerehabilitation Care Service Delivery Model for Stroke Survivors in The Rio Grande Valley PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the feasibility of a mobile telerehabilitation software for post-acute stroke care for Rio Grande Valley (RGV) stroke survivors with community health worker (CHW) at-home support and to estimate the functional health, mental health (depression), and caregiver burden outcomes of this new CHW-supported, at-home rehabilitation service delivery model and to identify salient barriers to and facilitators of adopting and delivering the new rehabilitation delivery model to further disseminate the model in real-world communities. |
FADI MUSFEE; | 2025-03-17 |
| 119 | Virtual Reality (VR) Platform and Transcutaneous Electrical Nerve Stimulation (TENS) for Early Stroke Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is one of the leading causes of disability, leaving millions of individuals each year impaired with lasting motor and sensory impairments. In the subacute phase, which goes from the first week to 3 months post-stroke, the patient has the highest recovery, which could be boosted by proper technologies intended for the rehabilitation of the patients. The impairments that the patients experience are extremely heterogeneous and go from muscle weakness to spasticity of the paretic side of the body. Beyond motor deficits, … |
STANISA RASPOPOVIC; | 2025-03-17 |
| 120 | Genetic and MRI Biomarkers of Neuroplasticity Predict Aphasia Recovery and Phenotypes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized brain networks and a molecular level of neuronal repair and plasticity. The proposed work will evaluate genetic and neural network biological markers of neuroplasticity associated with variability in aphasia, … |
HALEY DRESANG; | 2025-03-17 |
| 121 | A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy (ICAS LVO-MT) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, multicenter, randomized controlled, open-label, blinded outcome evaluation (PROBE) trial |
JIANMIN LIU; | 2025-03-15 |
| 122 | Aleeto in Acute ISchemic Stroke：A RandomISed Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective, double-blind, 1:1:1 randomized controlled study aimed at evaluating the efficacy and safety of Aleeto treatment compared to placebo in improving the NIHSS score at 14 days in patients with moderate to severe acute ischemic stroke. It also aims to explore the neuroprotective effects of Aleeto in moderate to severe acute ischemic stroke and provide data support and evidence for future clinical trials and evidence-based medicine. |
YILONG WANG; | 2025-03-15 |
| 123 | Efficacy of Shock Wave Therapy in Patients with Muscle Spasticity After A Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the efficacy and safety of shock wave therapy (SWT) in reducing muscle spasticity in patients who have suffered a stroke. The main questions it aims to answer are: Does SWT reduce muscle tone and improve joint range of motion in post-stroke patients with spasticity? Does SWT improve the quality of life for these patients? What side effects, if any, … |
MARIA BLANCO DIAZ; | 2025-03-15 |
| 124 | Exploration of Repeated High-frequency Transcranial Magnetic Stimulation for The Treatment of Acute Phase Aphasia in Post-stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is currently an important cause of death and disability among adults worldwide, with acute ischemic stroke being the most common type of stroke, accounting for 69.6% -72.8% of new strokes in China. The time division of the acute phase generally refers to the onset time within 1-2 weeks. About 21-38% of stroke patients have post-stroke aphasia. Post stroke aphasia is usually an acquired language disorder caused by damage to the language functional areas of the dominant hemisphere, characterized by varying degrees of impairment in some or all language functions, including speaking, listening and understanding, paraphrasing, naming, reading, … |
FEI XIAO; | 2025-03-15 |
| 125 | Comparative Effectiveness of Ipsilesional High-frequency RTMS, Contralesional Continuous Burst Theta RTMS, and Sham RTMS, Each Combined With Physiotherapy, in Subacute Ischemic Stroke Upper Limb Recovery : Clinical, Neurophysiological and Radiological: A Double-blinded Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the efficacy of lesional high-frequency rTMS, contralesional cTBS, and sham stimulation in improving motor and cognitive recovery in post-stroke patients undergoing physiotherapy. |
MOHAMMAD AHMAD MOHAMMAD KORAYEM; | 2025-03-15 |
| 126 | Effects of NeuroReAlign Therapy on Cognition in Patients with Stroke: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to investigate the effects of NeuroReAlign Therapy on cognition in stroke survivors in the chronic stage (\>6 months). The study will include male and female participants aged 18-70 years. The main questions it aims to answer are: Does NeuroReAlign Therapy improve cognition in stroke survivors compared to conventional physiotherapy? Researchers will compare NeuroReAlign Therapy to conventional cognitive therapy to determine its effects on cognition. Participants will: Undergo NeuroReAlign Therapy or conventional cognitive therapy for 4 weeks. Have their cognition evaluated using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), … |
ANAS RADI HASSAN ALASHRAM; | 2025-03-15 |
| 127 | Rise & Shine: Promoting Sleep Quality in Chronic Stroke With Exercise PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: health problems, such as heart disease, diabetes, cognitive impairment, and dementia. After a person suffers a stroke, they often experience difficulties in getting a good night’s sleep. Approximately half of stroke survivors have insomnia, or have trouble falling and/or staying asleep. Poor sleep quality among stroke survivors increases the risk of recurrent stroke by 3-fold and the risk of early death by 76%. Hence, stroke survivors need strategies to promote better sleep. Fortunately, evidence shows that sleep quality can be improved with exercise, … |
TERESA LIU-AMBROSE; | 2025-03-15 |
| 128 | The Efficacy and Safety of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Recent Ingestion of Factor Xa-inhibitors Trial (SIFT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study looks at whether stroke patients who take FXa inhibitors (a type of blood thinner) can safely receive clot-busting treatment (IVT). IVT is a common emergency treatment for stroke, but current guidelines say it should not be given to people who have taken FXa inhibitors in the last 48 hours. This is because doctors worry that IVT might cause dangerous bleeding in the brain. However, … |
GURI HAGBERG; | 2025-03-14 |
| 129 | A Cross-Over Study on The Effect of Shoulder Sling Use on Balance and Functional Mobility in Patients With Hemiplegia During The Subacute Phase of Stroke Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines whether wearing a shoulder sling can improve balance and mobility in people who are recovering from a stroke. Participants will perform simple movement and balance tests twice-once with the sling and once without. The goal is to find out if using the sling helps patients feel more stable and safe during walking and everyday activities. |
ARNAOUTIS STYLIANOS; | 2025-03-13 |
| 130 | Effects of Cerebrolysin on Language Ability in Non-fluent Aphasia Patients After Stroke: A Randomized, Placebo-controlled, Double-blinded, Single Center Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to measure changes in language ability after adding cerebrolysin to standard treatment for non-fluent aphasia patients with post-stroke language impairment. The patients are divided into two groups: the experimental group, which receives a combination of standard treatment (speech therapy) and cerebrolysin, and the control group, which only receives standard treatment (speech therapy). By comparing the PK-WAB scores before and after drug administration, the study seeks to analyze the impact of cerebrolysin on language improvement. According to various stroke registries, … |
YONSEI UNIVERSITY | 2025-03-12 |
| 131 | A Randomised Trial of Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Older people falling from a standing height is the most common cause of hospital admission for head injury. Up to 1 in 3 patients admitted are taking a tablet medication which thins the blood, known as an oral anticoagulant. This type of medication can increase the likelihood of bleeding in the brain. Many patients are taking oral anticoagulation due to having an irregular heartbeat (called atrial fibrillation) or because of having a previous stroke or blood clots. When a scan shows blood in the brain, oral anticoagulation is nearly always stopped. However, … |
CATHERINE MCMAHON; | 2025-03-10 |
| 132 | General Anesthesia Versus Loco-Regional Anesthesia for Transcarotid Trancatheter Aortic Valve Replacement – A Retrospective Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcarotid transcatheter aortic valve replacement (Transcarotid TAVR) has been increasingly used as an alternative to the transfemoral approach. The general anesthesia, locoragional anesthesia or local anesthesia are three anesthesia techniques that can be used for transcarotid TAVR. We aim to compare the locoregional approach to gerneral anesthesia. |
RICHARD DESCAMPS; | 2025-03-07 |
| 133 | Effect of Plantar Vibration on Ankle Proprioception in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate the effect of plantar vibration on the ankle proprioception of patients with stroke. |
OMER DURSUN; | 2025-03-05 |
| 134 | Mini-Crush or Controlled Balloon-Crush for True Coronary Bifurcation Lesions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The mini-crush technique is one of the leading 2-stent techniques frequently applied by interventional cardiologists to treat complex bifurcation lesions. In the last 20 years, many technical innovations and iterations of mini-crush technique have been developed, and it maintains its popularity among invasive cardiologists. Moreover, mini-crush and double kissing-crush techniques have been compared in terms of clinical results in both left main and non-left main coronary bifurcation patient populations and no significant difference was found. However, … |
AHMET GUNER; | 2025-03-03 |
| 135 | Pilot Study on The Effects Induced By An Electromyographic-controlled Functional Electrical Stimulator (FitFES) for Upper Limb Rehabilitation in Post-stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Upper limb disabilities are among the most debilitating issues after a cerebral stroke. One promising approach in motor rehabilitation is the use of functional electrical stimulation (FES). This technique can be integrated into daily therapy to follow an adaptive approach, exploiting the residual capacities of patients. FES can help to stimulate the affected muscles, improve coordination and strengthen the weakened muscles, thus supporting the rehabilitation process. |
MAURIZIO FERRARIN; | 2025-03-03 |
| 136 | Effectiveness of Single-Lead Prolonged ECG Monitoring in Detecting New-Onset Atrial Fibrillation: Study Protocol for A Pragmatic Cluster-Randomized Controlled Rial PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Atrial fibrillation (AF) is a common arrhythmia associated with a significantly increased risk of stroke and heart failure. Early detection and appropriate anticoagulation therapy are critical for reducing the risk of stroke in AF patients. However, traditional screening methods, such as pulse palpation and 12-lead ECG, often fail to detect asymptomatic or paroxysmal AF. Newer technologies, such as long-term ECG monitoring, … |
BEIJING ANZHEN HOSPITAL | 2025-03-01 |
| 137 | Application-Delivered Patient Education in Enhancing The Usage of Apixaban in Patients With Atrial Fibrillation: Randomized Control Therapy PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: AF is the most common arrhythmia, with an overall prevalence of approximately 2%. It is particularly prevalent in individuals over 60 years old, affecting about 5% of this population. With the aging population, the global prevalence of AF is increasing. In South Korea, the overall prevalence of AF increased from 0.73% in 2006 to 1.53% in 2015, a 2.1-fold increase. By 2060, it is projected that 2.3 million people in Korea will have AF, with a prevalence rate of 5.81%. AF accounts for approximately 20% of all ischemic strokes, … |
YONSEI UNIVERSITY | 2025-03-01 |
| 138 | Patients with Acute Ischemic Stroke Receiving Ginkgo Diterpene Lactone Meglumine: A Patient Registry PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to investigate the effectiveness of Ginkgo Diterpene Lactone Meglumine (GDLM) for patients with acute ischemic stroke (AIS) in real-world settings. |
YING GAO; | 2025-03-01 |
| 139 | Sex Differences in Prehospital Acute Management of Suspected Stroke Patients PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Stroke is a leading cause for individual, family and societal harm with huge health-economic impact. Immediate and correct prehospital acute stroke pathway initiation is key for treatment success. Evidence points towards sex inequity in management pathways of acute stroke care. A complicating factor in acute stroke management is the diversity in clinical presentation among patients of different sex. This increases the challenges of correct prehospital identification. Most of the currently available data on male and female differences in acute stroke management come from patients with hospital-confirmed stroke. Little to no information is available about sex-related management differences of patients with prehospital suspected stroke, often missed by stroke quality databases. Objectives: To identify sex differences in EMS-delivered prehospital diagnostic accuracy and management of patients with suspected or confirmed acute stroke. Methods: International project collaboration to conduct a cross-regional cohort analysis of patients with a prehospital working diagnosis of stroke and/or hospital-confirmed stroke diagnosis. Relevance: More information and details about the reasons for a potential prehospital treatment inequity are a necessary next step for any improvement and subsequent development of structured training programmes for emergency medical service personnel. This project is the first large-scaled international collaboration addressing sex differences in prehospital stroke care. With this approach the project will not only lead to more urgently needed information, but will also serve as a lighthouse project for raising general awareness for this topic. |
UNIVERSITÄT DES SAARLANDES | 2025-03-01 |
| 140 | ADequate AntiPlatelet and Anticoagulation Therapy in Atrial Fibrillation Patients With Focus on Ischemic Risk Management A Randomized ADAPT AFFIRM Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Anticoagulation therapy is recommended for patients with atrial fibrillation (AF) in order to prevent ischemic stroke and systemic embolism. Meanwhile, lifelong antiplatelet therapy is highly recommended to prevent stent thrombosis and further ischemic adverse events after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation. In this context, in patients with AF undergoing DES implantation, anticoagulation and antiplatelet therapies perform their own unique roles. However, … |
YONSEI UNIVERSITY | 2025-03-01 |
| 141 | Efficacy and Safety of Human Urinary Kallidinogenase for Acute Ischemic Stroke Patients Receiving Reperfusion Treatment PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to explore the efficacy and safety of Human Urinary Kallidinogenase for acute ischemic stroke patients receiving intravenous thrombolysis and/or endovascular treatment. |
YILONG WANG; | 2025-03-01 |
| 142 | Guideline-diRected MAnagement for Chronic Kidney Disease: EValuation of An Education Progamme in A National Cluster Randomized Controlled Trial (GRAVER) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Study Objective: To evaluate the impact of guideline-based CKD comprehensive management medical re-education for community healthcare providers on improving cardio-renal outcomes in CKD patients. Study Design: A nationwide, multicenter, prospective, cluster-randomized controlled trial. Inclusion and Exclusion Criteria: Inclusion Criteria: Chronic kidney disease (CKD) patients meeting the following criteria: eGFR \<60 mL/min/1.73 m² or UACR \>30 mg/g on two separate occasions at least 3 months apart. Exclusion Criteria: Age \<18 years. End-stage renal disease (ESRD) with eGFR \<15 mL/min/1.73 m², ... |
JIYAN CHEN; | 2025-03-01 |
| 143 | Mechanisms And Prognosis of Stroke-Heart Syndrome PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes in stroke patients. However, the underlying mechanisms remain unclear, and there are currently no effective prevention or treatment strategies. This study aims to elucidate the neuro-humoral mechanisms of stroke-heart syndrome through multimodal imaging and multi-omics blood analysis. Additionally, it seeks to observe the progression of stroke-heart syndrome and its impact on functional outcomes, cognitive abilities, … |
CHENSHENG PAN; | 2025-03-01 |
| 144 | Prevalence of Central Neuropathic Pain After A Stroke in Patients Attending Post-stroke Consultations in The Île-de-France Region PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-stroke pain is common, affecting 15-50% of patients and significantly impacting their quality of life, rehabilitation, and functional recovery. There are different types of post-stroke pain, including peripheral pain related to spasticity, shoulder pain, complex regional pain syndrome, and headaches, as well as central pain linked to brain lesions. Central Post-Stroke Pain (CPSP) is diagnosed when the pain has neuropathic characteristics (burning, cold, tightness, compression), possibly accompanied by allodynia, hyperesthesia, and sensory-motor disorders localized to the area affected by the stroke. CPSP disrupts sleep, impairs functional rehabilitation, and can lead to depression, anxiety, substance abuse, … |
FONDATION HÔPITAL SAINT JOSEPH | 2025-03-01 |
| 145 | CAP-TEER: CerebrAl Protection During Transcatheter Edge-to-edge Repair PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcatheter edge-to-edge repair of the mitral valve (M-TEER) is a well-established endovascular treatment option for patients with severe mitral regurgitation who are at high risk for surgery-related complications. However, the procedure carries a risk of clinically overt strokes and imaging-detected brain lesions, which may potentially be mitigated through the use of cerebral protection devices. This prospective, multi-center, randomized, controlled study aims to assess the efficacy and safety of cerebral protection device, compared to a control group undergoing unprotected M-TEER. |
XIAO-DONG ZHUANG; | 2025-03-01 |
| 146 | Deciphering The Molecular Landscape of Diabetic Cardiovascular Complications Based on Multi-Omics Analysis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the molecular mechanisms underlying cardiovascular complications in individuals with type 2 diabetes (T2DM) and how they differ from healthy individuals. The study will also identify biomarkers and potential therapeutic targets for better managing diabetes-related heart disease. The main questions it aims to answer are: 1. What molecular changes are associated with cardiovascular complications in T2DM patients compared to healthy individuals? 2. How do genetic, gene expression, and protein profiles differ between T2DM patients with and without cardiovascular complications? Researchers will compare the molecular profiles of three groups: healthy controls, … |
SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2025-03-01 |
| 147 | Th Efficacy and Safety of Intravenous Thrombolysis in Acute Ischemic Stroke with Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary hypothesis being tested in this trial is that ischemic stroke patients with active cancer will have improved clinical outcomes when given intravenous thrombolysis compared to standard care. |
MIN LOU; | 2025-03-01 |
| 148 | Intravenous Thrombosis in Acute Ischemic Stroke Patients with Prior Ischemic Stroke Within 3 Months PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary hypothesis being tested in this trial is that ischemic stroke patients with prior ischemic stroke within 3 months will have improved clinical outcomes when given intravenous thrombolysis compared to standard care. |
MIN LOU; | 2025-03-01 |
| 149 | Early Cardiovascular Risk Assessment of Patients With COPD During Respiratory Exacerbation for The Identification and Treatment of Cardiovascular Comorbidity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a research study involving patients hospitalized for COPD flare-ups. Patients will be randomly assigned to two groups: one group will only see a pulmonologist (lung doctor), and the other group will also be seen by a cardiologist (heart doctor) during their hospital stay. Both groups will fill out a questionnaire, and the pulmonologist will review their lung disease, adjust their treatment, and recommend follow-up care. The cardiologist will also assess the second group for heart diseases (like high cholesterol, diabetes, heart disease, high blood pressure, … |
TEL AVIV SOURASKY MEDICAL CENTER | 2025-03-01 |
| 150 | A Randomized, Open-label, Investigator-led, Pilot Trial Investigating The Incidence of New-brain Lesions on Brain MRI and Safety Between Edoxaban and Apixaban in Patients with Stroke and Nonvalvular Atrial Fibrillation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine whether there is a difference in brain lesion occurrence and safety when brain MRI is followed up between edoxaban and apixaban in stroke patients with nonvalvular atrial fibrillation through exploratory clinical trials. |
TAE-JIN SONG; | 2025-03-01 |
| 151 | Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Patients with Low NIHSS and Non-disabling Deficits PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Minor stroke is considered an acute ischemic stroke (AIS) that has a National Institute of Health Stroke Scale (NIHSS) score ≤ 5 points. About 1/3 patients with mild stroke have poor prognosis, whether patients with this type undergo thrombolysis has been a controversial issue. A pooled analysis published in the Lancet in 2014 included 9 high-quality RCT studies of intravenous thrombolysis such as NINDS and IST3, and a total of 666 (10%) patients with mild stroke were included in the analysis. For mild stroke, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-03-01 |
| 152 | Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke: A Multicenter, Randomised, Proof of Concept, Phase 2a/b Trial in Patients Treated with Mechanical Thrombectomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The DOWN-SUITE study is multicenter, randomised, controlled, open-label clinical trial with blinded outcome assessment comparing collateral status in patients with acute ischemic stroke treated with an in-hospital application of head down tilt -10° to -15° (HDT15) versus usual positioning (0° to +30°) before endovascular mechanical thrombectomy. This study will involve adult patients who are eligible for mechanical thrombectomy and who have acute ischemic stroke due to left or right middle cerebral artery occlusion (M1 segment). The investigators hypothesise that HDT15, applied in acute ischemic stroke patients with a large vessel occlusion, will improve collateral circulation, … |
SIMONE BERETTA; | 2025-03-01 |
| 153 | Exploring A Common Genetic Risk Factor for Heat Stroke and Dehydration PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults. The primary aim of the study is to estimate the risk of electrolyte disorders attributable to the CF carrier state in a genotyped cohort. This will be accomplished with two smaller projects- Aim 1 and Aim 2. Aim 1 will consist of 100 CF Carriers and 100 age- … |
AARON C. MILLER; | 2025-03-01 |
| 154 | Unlocking Trunk Potential After Stroke: A Novel Approach Combining Transcranial Direct Current Stimulation and Core Stability Exercise PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the effects of the combining transcranial direct current stimulation with core stability exercises on trunk performance in poststroke hemiparetic patients, the secondary outcome is to evaluate the balance and the functional performance of the participants. |
MOHAMMED YOUSSEF ELHAMRAWY; | 2025-03-01 |
| 155 | The Effect of Perioperative Targeted Fluid Therapy on Postoperative Cognitive Dysfunction in Coronary Artery Bypass Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Postoperative cognitive dysfunction (POCD) describes a decline in cognitive function as measured by pre- and postoperative neuropsychological testing. It is common after cardiac surgery, affecting 25% to 70% of patients, and is usually associated with pathophysiological mechanisms such as cerebral hypoperfusion, cerebral microemboli, glycaemic control and neurotoxic effects of anaesthetic agents. There are similar mechanisms between POCD and postoperative delirium (POD), both of which promote neuroinflammation through systemic inflammation and blood-brain barrier dysfunction. It has also been associated with concentrations of peripheral inflammatory markers (such as CRP, … |
GAMZE TALIH; | 2025-03-01 |
| 156 | The Effect of App. for Medication-check and Video-call Guided Education on APIXABAN Adherence in Patients of Atrial Fibrillation With Cardiac Disease: Randomised Control Pilot Study(APIXABAN Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to evaluate whether the medication reminder app and video call can improve medication adherence to apixaban in patients with AF and comorbidities. Patients with AF and comorbid heart disease taking apixaban who meet the inclusion criteria will be randomised 1:1 to a treatment arm using a medication reminder app and bi-weekly video education and a control arm using the medication reminder app alone to compare medication adherence. Patients in both groups will use the medication app, … |
DONG-JU CHOI; | 2025-03-01 |
| 157 | Effects of NeuroReAlign Therapy on Balance and Gait in Stroke Survivors: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to investigate the effects of NeuroReAlign Therapy on balance and gait in stroke survivors in the chronic stage (\>6 months). The study will include male and female participants aged 18-70 years. The main questions it aims to answer are: Does NeuroReAlign Therapy improve balance in stroke survivors compared to conventional physiotherapy? Does NeuroReAlign Therapy enhance gait performance more effectively than conventional physiotherapy? Researchers will compare NeuroReAlign Therapy to conventional physiotherapy to determine its effects on balance and gait. Participants will: Undergo NeuroReAlign Therapy or conventional physiotherapy for 4 weeks. Have their balance assessed using the Berg Balance Scale (BBS), Activities-Specific Balance Confidence Scale (ABC Scale), and Fear of Falling Questionnaire (FoFQ). Have their gait evaluated using the Dynamic Gait Index (DGI), Rivermead Mobility Index (RMI), Timed Up and Go (TUG), 6-Minute Walk Test (6MWT), and 10-Meter Walk Test (10MWT). Complete outcome assessments at baseline and after the intervention (week 4). |
ANAS RADI HASSAN ALASHRAM; | 2025-03-01 |
| 158 | Measuring Biomarkers for Health in Community Environments: EMBraCE Activity Program; Short Term Effect of Using Non-immersive Gamified Exercises on Chronic Shoulder Pain in People With Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rehabilitation after stroke is essential to minimize permanent disability. Gamification of exercises has emerged as a promising strategy for increasing motivation and rehabilitation efficacy in people with stroke. However, there is a gap in understanding how exercise gamification can aid in pain management among people with stroke who are experiencing shoulder pain difficulties. This study aims to evaluate the short-term effect of using gamified non-immersive exercises on shoulder pain level, upper limb range of motion, … |
HELEN DAWES; | 2025-03-01 |
| 159 | Effects Of Graded Activity Training and Task-Oriented Training on Fatigue in Post-Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized controlled trial is to determine the effects of Graded Activity Training and Task Oriented Training on Fatigue in Post-Stroke Patients. Until now there is very limited work found on fatigue so this will increase quality of life in stroke patients and potentially reduce burden on healthcare system. |
AROOSA TARIQ; | 2025-03-01 |
| 160 | Cortical Activation During Forward and Backward Walking in Individuals With Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After stroke, damage to one cerebral hemisphere disrupts the normal balance of activity between the two hemispheres. The affected hemisphere typically exhibits reduced excitability, whereas the unaffected side may demonstrate increased excitability. This phenomenon, referred to as interhemispheric imbalance, further inhibits activity in the affected hemisphere, thereby restricting motor recovery. According to the interhemispheric competition model, enhancing excitability in the affected hemisphere and/or suppressing excitability in the unaffected hemisphere may contribute to the improvement of motor function in individuals with stroke. Furthermore, as motor function recovers, … |
YEA-RU YANG; | 2025-03-01 |
| 161 | Pilot Study for SmartWatch-driven AF Detection in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Unrecognized atrial fibrillation (AF) is a common cause of ischemic stroke. Implantable event monitors (ICM) are the gold standard for continuous heart rhythm monitoring but they have been implemented in very few patients after stroke due to high invasiveness and high costs. In this trial, … |
UNIVERSITY OF LEIPZIG | 2025-03-01 |
| 162 | Comparison of Cardiac Index and Stroke-volume-index Measured By Pulmonary Artery Catheter, FloTrac® and Argos® in Cardiac Surgery Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A comparison of cardiac performance determined by stroke-volume-index measured by different mechanisms in patients during and after cardiac surgery: 1. Pulmonary artery catheter 2. Flo Trac 3. Argos Monitor Investigations will be done in theater and on ICU in ventilated and spontaneously breathing patients. |
MATTHIAS HERINGLAKE; | 2025-03-01 |
| 163 | The Effect of Backward Walking Observation Training on Improving Brain Activity and Gait Quality in People With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Walking impairment is one of the most common and concerning issues for individuals with stroke. Previous studies have often used improvements in walking speed and distance as reference indicators for gait performance progress in individuals with stroke. However, for people with chronic stroke, it may be more appropriate to prioritize improving gait symmetry and gait variability to enhance gait quality as a primary intervention goal. Additionally, stroke can lead to an imbalance in interhemispheric brain activity, which evolves as motor function recovers. According to the literature review, backward walking may extend the support time of the lower limbs, … |
YEA-RU YANG; | 2025-03-01 |
| 164 | C-arm Cone Beam CTP Guided Cerebrovascular Interventions: Evaluating Predictability and Accuracy for The Treatment of Acute Cerebral Ischemia in The Angiography Suite Related Papers Related Patents Related Grants Related Experts View Highlight: The study objective for the Phase 2 of this research is to demonstrate and confirm the substantial time savings that can be obtained using cone beam computed tomography (CB-CT) for both complete image acquisition and rapid image reconstruction in a Direct to Angio paradigm (One Stop Shop) for selected acute ischemic stroke (AIS) patients. |
BEVERLY AAGAARD-KIENITZ; | 2025-03-01 |
| 165 | Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease: A Randomised Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate whether a management strategy based on coronary computed tomography angiography (CCTA) for patients with non-obstructive coronary artery disease can improve the LDL-C target achievement rate compared to a traditional management strategy without follow-up CCTA, thereby reducing the incidence of major adverse cardiovascular and cerebrovascular events over a 3 years period, including all-cause mortality, myocardial infarction, ischemia driven revascularation and stroke. |
ZHANG LONGJIANG; | 2025-02-28 |
| 166 | PROVE-VR: A Pilot Randomized Trial Using Omnidirectional Virtual Reality and Treadmill Training for Chronic Stroke Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this pilot randomized controlled trial (RCT) is to test the feasibility (recruitment rate, retention rate, participant burden, adherence, technical issues, safety) and usability (system usability scale, SUS) of Omnidirectional treadmill Virtual Reality training (omni-VR) among chronic stroke survivors. Our secondary objective is to (1) estimate the extent to which cognition, brain activation during a dual task activity, walking ability, and dynamic balance change after 3 months of training among intervention participants (omni-VR) and traditional exercise controls, … |
ADRIA QUIGLEY; | 2025-02-28 |
| 167 | Cognitive Impairment Mechanisms and Training With Real Time-functional MRI Neurofeedback After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-stroke cognitive impairment (PSCI) is a common source of invisible disability. The actual techniques of cognitive remediation have been reported to have only a small effect, justifying the need to foster research in this field. Real-time functional MRI neurofeedack (rt-fMRI NF) is a procedure of brain-machine interface supporting self-regulation of brain activity, with promising results in the treatment of mental disorders. The main objective of the study is to evaluate in a pilot study, the ability of stroke patients to learn to self-regulate their brain activity in a priviledged direction, using rt-fMRI NF |
SHARMILA SAGNIER; | 2025-02-28 |
| 168 | The Fifth INTEnsive PReventing Secondary Injury in Acute Cerebral Haemorrhage Trial Within ACT-GLOBAL PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a domain within the ACT-GLOBAL platform trial to compare the effectiveness of early and appropriate pharmacological interventions in acute intracerebral hemorrhage (ICH) to control secondary brain injury. Up to 2000 patients with presumed spontaneous supratentorial intracerebral hemorrhage (ICH) will be followed for 6 months (or death, if prior to 6 months). Adaptive interim analyses will be used, … |
THE GEORGE INSTITUTE | 2025-02-27 |
| 169 | Stroke Homecare and Recurrence Prevention PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Significance: Stroke is the leading cause of death in China, placing a heavy burden on patients, families, and society. Despite advancements in acute stroke treatment, the recurrence rate remains high, and secondary prevention faces significant challenges. Current standard care does not fully address the diverse needs of stroke patients. Home-based health care (HBHC) offers a promising new intervention, providing continuous medical support, personalized lifestyle changes, and improved medication adherence, potentially reducing the risk of stroke recurrence. Study Objectives and Hypotheses: The study seeks to assess the impact of HBHC on reducing stroke recurrence, improving quality of life, … |
XUEJUN YIN; | 2025-02-27 |
| 170 | Secondary Prevention of Ischemic Stroke and Transient Ischemic Attack with An Intelligent System PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop a digital health-based intelligent management system for the secondary prevention of ischemic stroke and to evaluate its effectiveness through a multicenter randomized controlled trial, assessing its health economic value. Participants will receive usual care after discharge (control group) or be managed with a WeChat-based intelligent management system after discharge (intervention group). At one year, all patients will undergo face-to-face follow-up to assess clinical events, medication adherence, and the achievement of target risk factor levels. |
ZI-XIAO LI; | 2025-02-26 |
| 171 | Assessment of A Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to: 1. Assess the usability of the SynPhNe device in a home environment. 2. Evaluate the efficacy of the SynPhNe home use device to improve motor hand function in chronic stroke subjects as compared to standard care alone. |
PAOLO BONATO; | 2025-02-26 |
| 172 | Investigation of The Effect of Shoulder Pain on Joint Position Sense, Postural Control, Tactical Sensory and Muscle Strength in Chronic Hemiplegic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to reveal the effects of shoulder pain in chronic hemiplegic patients with a more comprehensive and holistic perspective through evaluation and correlation methods. It is thought that these evaluations can make significant contributions to the understanding of the etiology and treatment of post-stroke shoulder pain. The focus of the study is to deeply examine the effects of shoulder pain on joint position sense, postural control, tactile sense and muscle strength in chronic hemiplegic patients. |
METEHAN YANA; | 2025-02-25 |
| 173 | Mobile Cognitive Behavioral Therapy for Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the feasibility and acceptability of MAYA, a mobile cognitive behavioral therapy app for anxiety and mood disorders, in adults who have had a stroke. |
ABHISHEK JAYWANT; | 2025-02-25 |
| 174 | Effects of Rhythmic Auditory Stimulation on Upper-limb Movements, Function, and Quality of Life in Stroke Patients: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to to examine whether rhythmic auditory stimulation improved movement speed, movement function of executing activities of daily living, and movement recovery of the affected upper limb, … |
SHU-MEI WANG; | 2025-02-24 |
| 175 | Capstan Medical TMVR Study: First-in-Human Evaluation of The Capstan TMVR System PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective, multi-center, non-randomized first in human study to evaluate the safety and feasibility of the Capstan Medical TMVR System for intervention in adults with moderate-severe or greater mitral regurgitation who are not surgical candidates. |
CAPSTAN MEDICAL | 2025-02-24 |
| 176 | A Phase 2, Randomised, Double-blind, Positive-controlled, Multicentre Study of Tiprogrel in The Treatment of Patients with Acute Minor Ischaemic Stroke or High-risk Transient Ischaemic Attack PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to evaluate efficacy and safety of tiprogrel in the treatment of patients with acute ischemic cerebrovascular events. |
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH | 2025-02-21 |
| 177 | Personalised Health Motor and Cognitive Assistance System for RehAbilitation (PHRASE): A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicentric randomized controlled trial evaluating the effectiveness of digital technology, specifically a smartphone with integrated VR-and AR-based intervention, for at-home rehabilitation after stroke. The study focuses on combined motor and cognitive training for patients in the late subacute and chronic phases post-stroke. The intervention is provided through the Rehabilitation Gaming System application RGSapp, a goal-oriented, … |
EODYNE SYSTEMS SL | 2025-02-21 |
| 178 | Effect of Inspiratory Muscle Training on Respiratory Function, Diaphragm Thickness, Balance Control, Exercise Capacity and Quality of Life in People After Stroke: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to explore the effects of a 4-week protocol of inspiratory muscle training (IMT) at 50% maximum inspiratory pressure (MIP) on respiratory function, diaphragm thickness, balance control, exercise capacity, and quality of life in people after stroke. To ascertain the effect of IMT on the relationship between diaphragm muscle contraction and activation of other trunk muscles, this study also explores whether any effect of the 4-week IMT protocol on balance control is associated with changes in the anticipatory posture adjustments (APAs) time – the onset time of postural muscles during a required task (e.g., … |
LIU FANG; | 2025-02-21 |
| 179 | Targeting LDL-C to Less Than 0.8 Mmol/L in Patients After PCI With High Risk of Cardiovascular Disease: An Open-label, Assessor-blinded, Randomized Trial (REC-SAFETARGET Trial) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Extensive evidence from epidemiological, genetic, and randomized controlled trials (RCTs) of lipid-lowering therapies has firmly established a causal relationship between low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (ASCVD), establishing LDL-C as both a pathogenic risk factor and a critical therapeutic target. Lipid-lowering therapies targeting LDL-C have significantly decreased the overall risk in ASCVD patients. Consequently, current guidelines recommend, based on risk stratification, lowering LDL-C levels in high-risk ASCVD patients to \<1.4 mmol/L with a ≥50% reduction from baseline. Findings from PROVE IT-TIMI 22, IMPROVE-IT, ODYSSEY OUTCOMES, ... |
LING TAO; | 2025-02-20 |
| 180 | Sleep-Disordered Breathing in The Acute Phase After Stroke and Neuropsychiatric Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In people who have had a stroke or a transient ischemic attack (TIA), it is common to have problems with breathing patterns during sleep, particularly a condition called obstructive sleep apnea. Another common long-term problem after a stroke is post-stroke fatigue, which affects function and quality of life after stroke. There is currently no clearly effective treatment for post-stroke fatigue. We are investigating whether there might be a connection between sleep-related breathing disturbances, and the risk of developing long-term post-stroke fatigue The project is being conducted at Blekingesjukhuset Karlskrona, … |
JOSEPH AKED; | 2025-02-20 |
| 181 | Balloon Angioplasty for Minor Unstable Stroke With IntraCranial Atherosclerosis Stenosis (BAMUS-ICAS): A Prospective, Randomized, Multi-center Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke, especially in East and South Asia, and is significantly associated with stroke recurrence and early neurological deterioration (END) despite aggressive medical management. Minor stroke (National Institutes of Health Stroke, NIHSS score ≤ 5) patients with ICAS often has higher risk of END. The early realization of blood flow patency is closely related to the improvement of patient outcomes. Submaximal balloon angioplasty (SBA) as a safer and simpler intervention which can improve cerebral blood flow. Thus, … |
HUI-SHENG CHEN; | 2025-02-19 |
| 182 | Prophylactic Radiofrequency Left Atrial Posterior Wall Isolation (box Lesion Ablation) to Prevent Atrial Fibrillation After Cardiac Surgery (PROBOX): A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if an epicardial radiofrequency left atrial posterior wall isolation (box lesion ablation) prevents atrial fibrillation after cardiac surgery. The main question it aims to answer is: – … |
VASILY I. KALEDA; | 2025-02-17 |
| 183 | A Multi-Center, Randomized, Double-Blind, Parallel, Placebo-Controlled, Phase III Clinical Study to Evaluate Efficacy and Safety of SP-8203 (Otaplimastat) in Patients With Acute Ischemic Stroke Requiring Thrombolytic Therapy As Standard of Care PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study is designed to evaluate the efficacy and safety of the combination therapy of SP-8203 (otaplimastat) and thrombolytic standard of care in acute ischemic stroke patient. As a standard of care, thrombolytic therapy (for instance, recombinant tissue plasminogen activator) will be administered. When reperfusion is not achieved in spite of thrombolytic therapy, endovascular therapy can be performed. |
BEOM JUN KIM; | 2025-02-14 |
| 184 | Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants – The ASPERA International Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Advancing knowledge in ischemic Stroke PatiEnts on oRal Anticoagulants (ASPERA) study aims to investigate characteristics of ischemic stroke cases occurring in patients on oral anticoagulation for atrial fibrillation (AF) or other cardioembolic arrhythmias and to characterize short and long-term outcomes associated with different secondary prevention strategies to prevent stroke recurrences. The ASPERA study is a multicenter, observational, … |
SIMONA SACCO; | 2025-02-12 |
| 185 | Personalized Transcranial Magnetic Stimulation and Constraint Induced Language Therapy to Treat Mild Post-Stroke Aphasia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment |
H. BRANCH COSLETT; | 2025-02-11 |
| 186 | Zinc for Infection Prevention in Sickle Cell Anemia-2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized double-blinded placebo-controlled trial of zinc to reduce the incidence of severe or invasive infections in Ugandan children with sickle cell anemia (SCA) |
CHANDY JOHN; | 2025-02-10 |
| 187 | Perioperative Cerebral Function Assessment for Cardiac Surgery PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Perioperative neurological complications in cardiovascular surgical procedures are associated with a significant risk of mortality and disability. This study is aimed at identifying the specific risk factors associated with these neurological complications during the perioperation and developing a comprehensive predictive model designed to enhance clinical decision-making and improve patient safety. The research is divided into three key phases: preoperative, intraoperative, and postoperative, each involving targeted evaluations and continuous monitoring to provide a thorough assessment of patient risk and outcomes. |
SHUJUAN LI; | 2025-02-08 |
| 188 | Efficacy of Robotic Rehabilitation for Neuro Recovery of The Upper Limb in Subacute Stroke Survivors: An International Multicenter Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This multicenter international randomized controlled trial (RCT) evaluates the effectiveness of the Gloreha Sinfonia® robotic exoskeleton for upper limb rehabilitation in individuals with subacute post-stroke paresis. The study aims to determine whether robotic-assisted therapy improves voluntary motor control and coordination more effectively than conventional rehabilitation, as measured by the Fugl-Meyer Assessment (FMA) for the upper limb (motor component). Participants will be randomly assigned to one of two groups: * Experimental Group (EG): Robotic-assisted upper limb rehabilitation combined with conventional therapy. * Control Group (CG): Conventional therapy alone including upper limb rehabilitation. Clinical assessments will be conducted at baseline (T1), … |
SANAZ POURNAJAF; | 2025-02-06 |
| 189 | REdo TranScatheter Aortic Valve Replacement for Transcatheter AOrtic Valve FailuRE PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to generate clinical evidence on valve safety and performance in subjects treated by redo Transcatheter Aortic Valve Replacement (TAVR). |
GUILHERME ATTIZZANI; | 2025-02-06 |
| 190 | PA-ChatS: Feasibility of Delivering A First-Line Physical Activity Intervention After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to explore a new intervention that supports physical activity within the first 6 weeks after stroke. All participants will complete assessments at weeks 0 and 7. During weeks 1 through 6, participants will use a Fitbit Inspire to track their step counts and meet with an occupational therapist one time per week. They will also complete weekly surveys. Physical activity levels will be measured using surveys and a wearable activPAL monitor 6 times during the study: Weeks 1, 3, 5, 7, 12, and 24. |
EMILY KRINGLE; | 2025-02-05 |
| 191 | Effects of Strategy Training for Physical Activity on Executive Functions in Stroke Survivors With Cognitive Impairments: A Phase II Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to examine if combining strategy training and physical activity (STPA) works to improve executive function in community-dwelling adults with post-stroke cognitive impairment. The main questions it aims to answer are: * Does STPA and physical exercise alone lead to greater improvements in executive function among stroke survivors relative to the control intervention with education? * Does STPA outperform physical exercise alone in the efficacy of executive functions? * Do the effects of STPA on executive functions transfer to the global cognition, balance, … |
FENG-HANG CHANG; | 2025-02-03 |
| 192 | Bifocal Transcranial Alternating Current Stimulation Targeting The Frontoparietal Network in Stroke Patients to Enhance Network Connectivity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hand and arm function is often significantly impaired in stroke patients, making its recovery a primary goal in rehabilitative treatment. This study investigates the effects of bifocal transcranial alternating current stimulation (tACS) on the frontoparietal network in stroke patients during the subacute to chronic recovery phase. By using non-invasive brain stimulation, … |
FANNY QUANDT; | 2025-02-03 |
| 193 | Safety and Efficacy of Remote Ischemic Conditioning in Patients with Severe Stenosis or Occlusion of Anterior Intracranial Circulation Vessels PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to examine whether remote ischemic treatment can better the 90 – day neurological outcomes in acute ischemic stroke patients having severe stenosis or occlusion of anterior intracranial circulation vessels. |
WEI HU; | 2025-02-01 |
| 194 | Efficacy of Music-Based Telerehabilitation After Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if a music-based telerehabilitation intervention implemented at home works to treat different kinds of neurological deficits caused by stroke. The main questions it aims to answer are: 1) Can the music intervention improve recovery of cognitive, verbal, motor, and emotional deficits after stroke, 2) can the music intervention enhance structural and functional recovery of the brain, and (3) how different demographic, musical, … |
TEPPO SARKAMO; | 2025-02-01 |
| 195 | ‘Thrombectomy in High-Risk Pulmonary Embolism – Device Versus Thrombolysis Netherlands’: TORPEDO-NL PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: TORPEDO-NL will be an investigator-initiated, academically sponsored, multicentre, open-label, randomized controlled trial (RCT). Patients with high-risk pulmonary embolism (PE) require immediate reperfusion therapy on top of anticoagulation. The standard reperfusion treatment in these patients is full-dose systemic thrombolysis. This carries a significant risk of major bleeding (10-25%) and intracranial haemorrhage (ICH, … |
ERIK KLOK; | 2025-02-01 |
| 196 | The Impact of Age on Short-term Post-thrombectomy Outcomes in Patients Aged 70 or Beyond With Acute Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A recent Cochrane systematic review of 18 randomized controlled trials (RCTs) comparing endovascular intervention-either mechanical thrombectomy or intra-arterial thrombolysis combined with medical treatment-to conservative medical treatment alone provided high-certainty evidence that endovascular intervention increases the likelihood of achieving a favorable functional outcome (modified Rankin Scale \[mRS\] score of 0-2) by 50% in patients with acute ischemic stroke (AIS).1 More recently, a cross-Atlantic RCT was conducted to determine whether endovascular therapy (EVT) plus medical care is superior to medical care alone in patients with acute proximal cerebral vessel occlusion in the anterior circulation and large infarcts, … |
VICTOR C. KOK; | 2025-02-01 |
| 197 | Investigating The Effects of Beta Transcranial Stimulation to Advance Stroke Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-invasive brain stimulation (NIBS) has the potential to boost rehabilitation after stroke by creating a ‘pro-plastic’ environment, where the brain is more adaptable in response to movement (motor) training. However, responses to classical NIBS protocols are highly variable. Movement-related changes in specific brain rhythms have previously been shown to be related to recovery of hand/arm function after a stroke. The investigators propose to use NIBS to target movement-related activity in the beta band (13-30Hz) within the motor cortical regions of the brain. The investigators will use a type of NIBS called transcranial alternating current stimulation (tACS), … |
CHARLOTTE J STAGG; | 2025-02-01 |
| 198 | STEP: StrokeNet Thrombectomy Endovascular Platform PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: STEP is a Randomized, Multifactorial, Adaptive Platform trial that seeks to optimize the care of patients with acute ischemic stroke (AIS) due to large (LVO) or medium vessel occlusions (MVO). |
JORDAN ELM; | 2025-01-31 |
| 199 | Potential Effects of A Robot-based Upper Limb Rehabilitation Paradigm in Different Subgroups After Stroke: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sensorimotor function of the upper limb is often impaired after stroke, even in the chronic phase (minimum 6 months after stroke). Currently, an optimal intervention combining both motor and sensory function, with focus on sensory processing (one of the most important sensory functions), does not exists. However, our research team has developed a novel therapy paradigm combining robot-based training, a transfer package to daily life activities, and a home program. As a first step, … |
GEERT VERHEYDEN; | 2025-01-31 |
| 200 | Standardized Goal-Directed Vs. Self-Directed Valsalva Maneuver for The Assessment of Patent Foramen Ovale PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Ischemic stroke represents a major public health issue, leading to significant disabilities and deaths worldwide. When no clear cause for stroke is found following a comprehensive cardiovascular evaluation (no atrial fibrillation, cardiac masses, or atherosclerosis) i.e. cryptogenic stroke, it is recommended to search for a patent foramen ovale (PFO), … |
DAVID MESSIKA-ZEITOUN; | 2025-01-30 |
| 201 | EVALUATION OF THE EFFECTS OF EARLY APPLICATION OF BOTULINUM TOXIN IN PATIENTS WITH A FIRST CEREBRAL VASCULAR EVENT PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines the early use of botulinum toxin in patients recovering from their first stroke to help reduce muscle stiffness and improve mobility. Spasticity, a condition that causes abnormal muscle tightness, is a common complication following strokes. It can result in decreased independence, pain, joint contractures, and difficulty performing daily activities. Early intervention is critical to prevent long-term complications and improve recovery outcomes.The participants are men and women aged 18 and older who have recently experienced their first stroke. These patients, admitted to the Regional General Hospital No. 1 Lic. Ignacio García Téllez in Mérida, Yucatán, … |
ROBERTO CARLOS PECH ARGUELLES; | 2025-01-28 |
| 202 | Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients on New Oral Anticoagulants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: New oral anticoagulants (NOACs), including rivaroxaban, apixaban, dabigatran, and edoxaban, have become the first-line therapy for preventing ischemic stroke associated with non-valvular atrial fibrillation (NVAF). Despite the effectiveness of NOACs in preventing thromboembolic events, approximately 1% to 2% of patients taking NOACs experience an ischemic stroke annually. Intravenous thrombolysis is an important means of treating acute ischemic stroke (AIS). However, due to concerns about the risk of symptomatic intracranial hemorrhage (sICH) or other severe bleeding complications, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-01-27 |
| 203 | Y-SCOPE Study: A Pilot Study to Assess Optimal Prevention and Outcome Improvement in Young Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose The Y-SCOPE study aims to improve the health and recovery of young adults aged 18 to 65 who have experienced an ischemic stroke or a high-risk transient ischemic attack (TIA). By focusing on personalized care and lifestyle changes, the study seeks to reduce the chances of another stroke and promote better long-term health. Background While strokes are often associated with older adults, recent studies have shown an increase in ischemic strokes among younger individuals. Given that younger patients are typically in their working years and have longer life expectancies, … |
IRCCS NATIONAL NEUROLOGICAL INSTITUTE C MONDINO FOUNDATION | 2025-01-20 |
| 204 | Optimizing Adherence to The Treatment of Sleep Apnea Among Patients With Stroke Undergoing Inpatient Rehabilitation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The SCOUTS 3 study aims to test the effectiveness of an intensive CPAP (Continuous Positive Airway Pressure) therapy support program compared to usual care in stroke patients with obstructive sleep apnea (OSA) during inpatient rehabilitation (IPR). The study is a multicenter randomized controlled trial (RCT) involving recruitment of about 250 participants across two institutions and randomization of about 200 participants. It compares an intensive support (IS) program for CPAP use with standard support (SS) to evaluate the effectiveness of the IS intervention in increasing CPAP usage during and after stroke rehabilitation. The Intensive Support (IS) group will receive a multicomponent intensive behavioral adherence program, which includes a CPAP technical support intervention, Motivational Enhancement Therapy (MET), and a Mobile Health intervention. Outcomes measured include CPAP adherence as measured by average nightly use in minutes between randomization and 3 months and the modified Rankin Scale (mRS-9Q) to evaluate stroke recovery. |
SANDEEP KHOT; | 2025-01-15 |
| 205 | Registry of Acute Coronary Syndrome in The Regional Cardiovascular Center PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a prospective registry of patients consequently admitted to the regional cardiovascular center with a diagnosis of acute coronary syndrome, in order to study the behavior of patients from the first minutes of the onset of the anginal syndrome, and influence of the delay in calling of ambulance on short-term and long-term outcomes of the disease. Other factors which may influence short-term and long-term outcomes will also be assessed. |
NATIONAL MEDICAL RESEARCH CENTER FOR THERAPY AND PREVENTIVE MEDICINE | 2025-01-15 |
| 206 | Stroke Patients’ Preferences for An Exoskeleton for Lower Limb Rehabilitation Using The DCE Method PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of this study is to investigate the preferences of individual stroke patients for key features of an exoskeleton, intended for lower limb rehabilitation, with a view to its potential integration into the design of future exoskeletons. This will be a multicenter study. Patients will be presented different scenarios of choices about the attributes about gait exoskeleton. Conditional logistic regression models will be used to define the preferences of the subjects. |
UNIVERSITY HOSPITAL BREST | 2025-01-15 |
| 207 | Pilot Study of Usability and Acceptability for The Optimization of A Functional Electrical Stimulator Controlled By Electromyographic Signal for The Rehabilitation of The Upper Limb in Persons Post-stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Functional recovery of the upper limb after a cerebral stroke is one of the major critical issues in rehabilitation. The advent of innovative technologies can be helpful to rehabilitators and intervene where there is no other solution but a clear therapeutic indication. The use of functional electrostimulators can actively and functionally support movements, helping people affected by stroke to complete a motor gesture taking into account their residual capacities. |
MAURIZIO FERRARIN; | 2025-01-14 |
| 208 | Telephysical Therapy As A Secondary Stroke Prevention Tool PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the effectiveness of telephysiotherapy as a rehabilitation and secondary prevention tool in patients with minor stroke, TIA, or LACI, comparing an experimental group receiving tele-assisted aerobic and anaerobic exercises to a control group. |
IGNACIO PASTOR RUIZ; | 2025-01-14 |
| 209 | Stroke in Working Age and Job Accommodation in Facilitating Transition Back to Work PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized controlled trial (RCT) is to investigate whether cognitive job accommodation intervention enhances return to work, work ability and performance after ischemic stroke in working-age population. The main questions are: * Does the cognitive job accommodation intervention affect absenteeism and presenteeism after stroke? * Does the intervention affect work ability and perceived cognitive and emotional difficulties at work? * Does the intervention decrease mental strain, … |
TEEMU I PAAJANEN; | 2025-01-10 |
| 210 | Mapping Corticoreticulospinal Motor Control Using Brainstem and Spinal Cord FMRI in Chronic Hemiparetic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke. |
MOLLY BRIGHT; | 2025-01-10 |
| 211 | Mapping The Time Course of Recovery of Sitting and Standing Balance and Walking After Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to understand how balance and walking abilities recover after a stroke, using innovative tools like an interactive assessment game. By observing patients over time, the investigators seek to identify recovery patterns that can improve rehabilitation strategies tailored to individual needs. Interacting with a game designed to assess balance and movement, participants will perform tasks involving sitting balance, standing balance, and gait initiation. The game measures aspects like reaction time, movement accuracy, and postural control, providing detailed insights into recovery progress. These data will validate prediction models to support personalized care. The study is non-invasive, … |
EVA SWINNEN; | 2025-01-07 |
| 212 | Graviceptive Neglect After Stroke: Clinical, Neuroanatomical and Physiological Effects of Focal Neuromodulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We aim to determine if targeted high-definition transcranial direct current stimulation (HD-tDCS) can safely correct errors in visual verticality perception in patients after stroke affecting either hemisphere. |
TAIZA G. S. EDWARDS; | 2025-01-03 |
| 213 | Prediction of Left Ventricular Adverse Remodeling and Major Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction Though Plasma Multiomics Analysis PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To identify plasma multi-omics biomarkers that predict left ventricular adverse remodeling (LVAR) and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction, and to investigate the molecular pathways linked to LVAR and MACE. |
XU WANG; | 2025-01-01 |
| 214 | Investigation of The Acute Effect of Local Vibration Application on Gait and Balance in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the research is to examine the acute effect of local vibration application on gait and balance in stroke patients. |
SANIYE AYDOĞAN ARSLAN; | 2025-01-01 |
| 215 | The Effect of Dual-task Training Combined with TDCS on Cognitive-motor Interference and Related Brain Activity in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate tDCS combined with cognitive-motor training on dual-task interference during dual-task walking, dual-task foot pedaling and the corresponding alterations of brain activity. |
THE HONG KONG POLYTECHNIC UNIVERSITY | 2025-01-01 |
| 216 | The Characteristics of Cardiovascular Imaging Alterations in Patients with Fabry Cardiomyopathy: A Prospective, Multicenter, Observational Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by α-galactosidase A (GLA) gene mutations leading to reduced or undetectable α galactosidase A (α-Gal A) enzyme activity, resulting in progressive accumulation of globotriaosylceramide (GL3) and its deacylated form globotriaosylsphingosine (Lyso-GL-3) in multiple organs, causing neural, renal, cardiac, dermatological, gastrointestinal and ophthalmic manifestations, even leading to life-threatening complications. Cardiovascular and cerebrovascular complications (i.e. heart failure, stroke, etc.) or end-stage renal disease even premature death can be seen in severe cases. The life expectancy of male patients is reduced by 15\~20 years, … |
LEI SONG; | 2024-12-31 |
| 217 | Augmented Reality for Stroke Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to determine the effectiveness of Augmented reality on motor function, balance, and functional ambulation in stroke patients. |
ARSHAD NAWAZ MALIK; | 2024-12-31 |
| 218 | Neural Operant Conditioning to Improve Walking After Stroke Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if operant conditioning can reduce spasticity in order to improve walking in stroke patient. The main questions it aims to answer are: * Can participants self-regulate reflex excitability * Can participants self-regulate reflex, reduce spasticity and improve walking Participants will undergo surface stimulation to evoke spinal reflexes and will be asked to control these reflexes therefore reducing spasticity. Researchers will compare result to able bodied participants to see if \[insert effects\] |
JAMES SULZER; | 2024-12-31 |
| 219 | Relationship of Respiratory Muscle Functions With Balance and Gait in Chronic Ischemic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke, which can occur due to many different causes and is one of the most common neurological conditions, is one of the main causes of disability worldwide. The most common disorders that occur after stroke are motor disorders. In addition, respiratory problems such as changes in breathing patterns and decreased ventilation function may accompany these patients. Respiratory problems are an important risk factor in the development of long-term mortality for both cardiovascular diseases and stroke. With all these changes, a serious decrease in patients’ activity performance is observed. While the focus is on motor function losses in stroke rehabilitation, … |
SÜMEYYE AKÇAY; | 2024-12-28 |
| 220 | EXCLAMATORY: EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation With Exercise CapacitY Longitudinal Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF). |
CORY TRANKLE; | 2024-12-26 |
| 221 | Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral small vessel disease (cSVD) is a common accompaniment of aging. Recent small subcortical (or lacunar) infarcts (i.e. symptomatic cSVD) and white matter hyperintensities are typical cSVD lesions on neuroimaging. cSVD causes about a quarter of ischaemic strokes and related with cognitive dysfunction. However, few studies are available so far to especially explore the treatment of cSVD. Endothelial dysfunction plays an important part in cSVD. Cilostazol and isosorbide mononitrate have endothelial protective function. We designed this prospective cohort study in China, … |
WANG ZHAOLU; | 2024-12-20 |
| 222 | A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Trial to Assess Efficacy and Safety of Omecamtiv Mecarbil in Patients with Symptomatic Heart Failure with Severely Reduced Ejection Fraction (COMET-HF) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction. |
CYTOKINETICS | 2024-12-19 |
| 223 | A Randomized Clinical Trial Comparing Three Anti-Thrombotic Strategies for Patients with Atrial Fibrillation and Severe Chronic Kidney Dysfunction PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: VISIONAIRE (Vitamin K AntagonISt, Factor Xa Inhibitor Or Nothing In Atrial Fibrillation And DIalytic End-stage Renal DiseasE) trial will be a prospective randomized open-label with blinded endpoint adjudication trial including 1500 patients with atrial fibrillation or atrial flutter and advanced chronic kidney disease |
HOSPITAL SIRIO LIBANES | 2024-12-18 |
| 224 | Personalized Transcranial Direct Current Stimulation in Stroke Recovery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The central objective of this application is to explore the neural substrate of personalized tDCS (ptDCS) and to determine whether the paradigm for each stroke patient can predict the amount of sustained clinical improvement through increased connectivity as measured by a biomarker of plasticity. |
TIMEA HODICS; | 2024-12-18 |
| 225 | Multicenter Real-World Cohort Study Evaluating The Impact of Early Intensive Lipid-Lowering Therapy on The Prognosis of Acute Coronary Syndrome Patients PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to evaluate the impact of early initiation of PCSK9 inhibitor therapy for intensive lipid-lowering in Chinese patients with acute coronary syndrome (ACS) during hospitalization on the rate of lipid goal attainment, the time to achieve guideline-recommended lipid levels within one year, and the incidence of adverse cardiovascular events. The primary research question is whether early initiation of PCSK9 inhibitor therapy during hospitalization for ACS patients in a real-world Chinese setting can increase the rate of lipid goal attainment, shorten the time to reach guideline-recommended lipid levels within one year, … |
YUN DAI CHEN; | 2024-12-16 |
| 226 | Efficacy of The Improving Participation After Stroke Self-Management-Rehabilitation (IPASS-R) Program in Sub-acute Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this proposed study is to evaluate the efficacy of a small-group, stroke-specific, self-management program delivered via telehealth to improve self-efficacy, activity performance, and quality of life in individuals with sub-acute stroke. |
ANNA BOONE; | 2024-12-16 |
| 227 | Effect of Jigsaw Technique on Learning Knowledge About Stroke Patient Care in Nursing Students PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In the literature, problem-based learning, case discussions and case scenarios, and simulation applications are used in stroke patient care nursing education. However, the use of the jigsaw technique is quite limited. Based on this information, it is anticipated that stroke patient care education provided with the Jigsaw technique can increase nursing students’ cooperation and communication skills, allowing them to acquire more effective and comprehensive knowledge in clinical care. |
BILECIK SEYH EDEBALI UNIVERSITESI | 2024-12-15 |
| 228 | Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of TEAM-HF IDE clinical trial is to evaluate safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart failure patients who are not dependent on intravenous inotrope. |
PATRICK CAMPBELL; | 2024-12-13 |
| 229 | CEREBELLO-MOTOR NEUROMODULATION AFTER STROKE PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The CERSTIM study is a physiopatholgical study investigating transcranial alternating current stimulation in stroke patients in the cerebello-motor loop. The design is a cross over design testing two frequencies in the gamma band and one placebo. We will use behavioural data, functional MRI, and Electroencephalography to disentangle the effect of tACS and its frequency. Healthy participants will be also recruited. |
CHARLOTTE ROSSO; | 2024-12-13 |
| 230 | Prospective, Multi-centre Clinical Investigation Evaluating The Outcomes of Patients Treated By Redo Transcatheter Aortic Valve Implantation for Bioprosthetic Valve Failure of A Transcatheter Aortic Valve PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcatheter aortic valve implantation (TAVI) is a key-hole technique to replace an aortic heart valve that is narrowed and/or leaking. Although TAVI is a safe and effective treatment for a faulty aortic heart valve, the new TAVI valve will not last forever. Because it is a ’tissue’ valve (made from the lining of a cow or pig heart), the valve will fail after a period of time as the tissue degenerates. When the TAVI valve fails, a viable treatment option is to perform a ‘Redo TAVI’ procedure, … |
DANIEL BLACKMAN; | 2024-12-12 |
| 231 | Utilizing A Brain-Computer Interface for Observational Imitation Training to Enhance Upper Limb Motor Recovery Post-Stroke: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: 1) To compare the effects of closed-loop brain-computer interface (BCI) driven observational imitation training versus sham BCI open-loop observational imitation training on improving upper limb motor functions in patients with stroke; 2) To investigate whether stroke patients receiving closed-loop training exhibit higher activation levels in the mirror neurons, measured by event-related desynchronization (ERD), compared to those receiving open-loop training. Hypothesis to be tested: The closed-loop training is more effective than open-loop training in improving upper limb motor outcomes, … |
THE HONG KONG POLYTECHNIC UNIVERSITY | 2024-12-12 |
| 232 | Quality Improvement Initiative for Enhancing Early Mobilization in Intracerebral Hemorrhage Patients: Pre-Post Implementation of A Structured Clinical Pathway PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary intracerebral hemorrhage (ICH) is a severe and life-threatening condition with a high mortality rate, reaching up to 50% within the first month. Survivors are often at risk of long-term disability due to the extensive brain damage caused by the hemorrhage. Unlike ischemic stroke patients, ICH patients are typically younger, face longer hospital stays, and are more likely to experience acute complications. Modern treatment approaches have shifted from focusing solely on reducing mortality to minimizing disability and enhancing functional outcomes through early rehabilitation. However, the optimal timing and intensity of early mobilization remain unclear, especially for patients with severe ICH, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2024-12-10 |
| 233 | Incidence of Fragility Fractures and Osteoporosis Screening in Chronic Stroke Patients: A Prospective Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a known risk factor for the development of osteoporosis, leading to an increased risk of falls and fractures. Several international studies have associated stroke with hip fractures, … |
PROF.SSA GIULIA LETIZIA MAURO; | 2024-12-10 |
| 234 | Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity in The Real World PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective database study which includes administrative medical and pharmacy claims linked with clinical and laboratory measurements for patients in the US, to evaluate the effectiveness of once-weekly semaglutide 2.4 mg in reducing the risk of CV and other obesity-related clinical outcomes. |
NOVO NORDISK | 2024-12-06 |
| 235 | Neuroarchitectural Recovery Model of Post-stroke Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The societal burden of stroke patients with persistent neurological deficit is high. It is therefore imperative that the mechanisms of rehabilitation-induced motor recovery be better understood in the hopes of developing more efficacious rehabilitative therapy. The treatment outcomes of people with stroke after rehabilitation vary, with up to 60% of people having residual impairment of the upper limb function. The high variability in rehabilitation-induced recovery prompted researchers and clinicians to develop more efficacious rehabilitative interventions for functional regain in post-stroke patients. However, … |
SAI KAM HUI; | 2024-12-01 |
| 236 | The Blood Proteome Profiling Identifies Biomarkers Associated with Prognosis in Ischemic Stroke Due to Large Artery Atherosclerosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Endovascular thrombectomy and intravenous thrombolysis have become key therapeutic approaches for acute ischemic stroke. However, due to time window limitations, many patients are unable to receive reperfusion therapy, and the majority only receive supportive treatment. Ischemic stroke-related complications, including edema and infection, gradually subside after 7 days post-stroke, with the patient’s condition generally stabilizing. Endogenous repair mechanisms will play a critical role in the coming months. This study aims to predict prognostic biomarkers for ischemic stroke patients who have not undergone reperfusion therapy, … |
JI XUNMING; | 2024-12-01 |
| 237 | Efficacy and Safety of Early Combined Therapy with PCSK9 Inhibitors and Statins in Acute Ischemic Stroke (CAPTAIN)–A Multicenter, Prospective, Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an investigator-initiated, multicenter, prospective, open-label, endpoint-blinded, randomized controlled trial (PROBE design) that includes patients with moderate or severe symptomatic intracranial large vessel atherosclerotic stenosis (sICAS) who present with acute ischemic stroke within 48 hours of symptom onset. Patients will be centrally randomized in a 1:1 ratio into two groups: Experimental Group: A single subcutaneous injection of 420 mg evolocumab upon admission, combined with standard doses of atorvastatin 20 mg or rosuvastatin 10 mg, along with other standard guideline-based medical treatments. Control Group: Standard doses of atorvastatin 20 mg or rosuvastatin 10 mg, … |
XIANG LUO; | 2024-11-29 |
| 238 | From Clinic to Smartphone: Evaluating The I-TUG for Balance and Fall Risk in Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigated the test-retest reliability and construct validity of the i-TUG, standard TUG, and Berg Balance Scale (BBS) using the EncephaLog smartphone application in individuals with chronic ischemic stroke. A total of 49 participants were assessed in two sessions to evaluate test-retest reliability. Construct validity was analyzed using Pearson correlation coefficients. Standard Error of Measurement (SEM) and Minimal Detectable Change (MDC) values were also calculated. |
MERVE SEVINC GUNDUZ; | 2024-11-25 |
| 239 | Comparison The Effectiveness of Stroke Volume Variation Versus Central Venous Pressure Guidance for Reducing Perioperative Blood Loss During Open Liver Resection: A Prospective, Double-Blinded, Noninferiority, Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Liver resection is a major surgery that can be associated with significant intraoperative blood loss and blood transfusion. Among high-volume centers, median intraoperative blood loss ranges between 300-800 ml. Excessive blood loss is a strong independent predictor of worsened postoperative outcomes, increasing morbidity and mortality rates by 20%-35%. Additionally, perioperative allogeneic blood transfusions are associated with deleterious outcomes, including tumor recurrence and increased rates of complications and death. The liver is a highly vascular organ with minimal vascular resistance, … |
WARANGKANA LAPISATEPUN; | 2024-11-25 |
| 240 | Transcutaneous Auricular Vagus Nerve Stimulation Combined with Rehabilitation Therapy for The Treatment of Post-stroke Dysphagia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present project is to use transcutaneous auricular vagus nerve stimulation (t-VNS) for the treatment of dysphagia in acute stroke patients to improve swallowing function and reduce mortality and disability related to this condition. 30 patients will be randomized into one of the two arms of the study: * REAL: real t-VNS + speech therapy * SHAM: t-VNS placebo + speech therapy. The experimental treatment consists in the association between t-VNS (real or placebo) and speech therapy exercises to improve swallowing functionality. Each patient will undergo a speech therapy rehabilitation session lasting approximately 40 minutes a day for 3 consecutive days, simultaneously with t-VNS on left ear. Swallowing function and clinical conditions will be evaluated before the intervention (baseline, T0), immediately after the intervention (T1) and 3 months after the intervention (T2). |
DI LAZZARO VINCENZO; | 2024-11-23 |
| 241 | Telehealth-Enhanced Assessment and Management After Stroke-Blood Pressure (TEAMS-BP) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: TEAMS-BP is a Patient-Centered Outcomes Research Institute (PCORI)-funded trial under the Phased Large Awards for Comparative Effectiveness Research (PLACER) funding mechanism to evaluate two comprehensive and evidence-based strategies for managing blood pressure (BP) following stroke. |
CHERYL BUSHNELL; | 2024-11-15 |
| 242 | Survey on Predictors of Discharge from Stroke Units in Argentina PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction Patients who receive care from stroke units are more likely to survive their stroke, become independent, and return home. Decision-making to decide the location of discharge is influenced more by non-clinical factors than clinical ones. Objective To analyze the factors that are considered for discharge and how stroke patients are measured in stroke units in Argentina by the physicians who make the decisions. Materials and methods An observational, analytical, … |
GERARDO CANDONI; | 2024-11-15 |
| 243 | Art Therapy and Its Effect on Non-Motor Function Rehabilitation in The Subacute Phase of Stroke Recovery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is one of the leading causes of disability and death worldwide, with the number of stroke patients steadily increasing due to the aging population. While traditional rehabilitation methods, such as pharmacological treatment, physical therapy, and cognitive therapy, can improve physical function to some extent, many stroke patients still face long-term non-motor impairments, including deficits in emotional, cognitive, and social functioning. Art therapy, as an integrative, non-invasive intervention, has gradually gained attention from researchers and clinicians due to its potential for restoring non-motor functions. Through artistic modalities such as music, painting, and dance, … |
ZEXI LIU; | 2024-11-15 |
| 244 | Art Therapy and Its Effect on Motor Function Rehabilitation in The Subacute Phase of Stroke Recovery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The target disease of this study is subacute ischemic stroke, a condition characterized by reduced blood flow to brain tissue due to arterial blockage, with a specific focus on the subacute recovery phase. This phase typically occurs within days to weeks post-stroke, making it a critical period for rehabilitation interventions to optimize functional outcomes and improve long-term prognosis. |
ZEXI LIU; | 2024-11-15 |
| 245 | FunctiOnal CaPaciTy Evaluation Using CardIopulMonary Testing and Stress EchocArdiography in Anderson-Fabry Disease Patients: OPTIMA-FD Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to observe the relation between excercise parameters – assessed by CPET – and rest/stress hemodynamic parameters – assessed by echocardiogram and CMR – in patients with a genetic diagnosis of Anderson-Fabry Disease. Participants will undergo: * baseline evaluation: clinical evaluation, disease staging with FASTEX and MSSI, KCCQ for quality of life assessment, resting 12-leads ECG, 6MWT, CPET-ESE and contrast-enhanced CMR; * before 36 months from baseline: resting 12-leads ECG, 2D rest and stress echocardiogram, CPET-ESE, contrast-enhanced CMR, disease staging with FASTEX and MSSI and KCCQ for quality of life assessment; … |
MASSIMO PIEPOLI; | 2024-11-13 |
| 246 | Abbott Medical – VERITAS Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the safety and effectiveness of Abbott’s Amulet™ 2 Left Atrial Appendage (LAA) occluder device (Amulet 2 device) in patients who have non-valvular atrial fibrillation and who are at increased risk for stroke and systemic embolism and have appropriate rationale to seek a non-pharmacologic alternative to oral anticoagulation. |
DEVI NAIR; | 2024-11-11 |
| 247 | A Functional MRI Study: Assessing Brain Function in Post Stoke Patients Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, single center, observational clinical study containing two cohorts the healthy cohort and post stroke cohort. A total of 13 subjects will be enrolled. Three (3) healthy volunteers will be enrolled in the healthy cohort. Ten (10) subjects who have recently experienced a mild to moderate acute ischemic stroke will be enrolled in the post stroke cohort. |
NEUROGLOVE | 2024-11-10 |
| 248 | Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test in moderately symptomatic chronic subdural hematoma (CSDH) patients if middle meningeal artery embolization (MMAE) can be used as an alternative to conventional open surgery. The main questions it aims to answer are: * Compared to open conventional surgery, … |
BERNARD BENDOK; | 2024-11-01 |
| 249 | The Impact of Chewing Food on Stroke Patients With Dysphagia: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore the effect of Chewing Food on quality of life and nutritional status in ischemic stroke patients. Patients will be randomly divided into an interventional group and a control group, all receiving routine rehabilitation treatment and enteral nutrition feeding. On this basis, the interventional group will receive Chewing Food training before each feeding for 10 min. Researchers will compare changes in quality of life, … |
BABUJINAYA CELA; | 2024-11-01 |
| 250 | Telerehabilitation Robotics for Upper Limb Rehabilitation After STroke (TRUST): A Study of Multi-cluster Adoption PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There has been an observed decrease in motor and functional ability and non-use of the impaired limb in chronic patients. This is due to the immediate drop in intensive daily therapy (5 days per week for 3 hours/day) that is usually provided during the inpatient (acute) phase upon discharge from the hospital. In this study, the investigators plan to address the low dosage of therapy in the post-acute discharge phase for stroke survivors. |
KAREN CHUA; | 2024-11-01 |
| 251 | Enhancing Post-Stroke Dysphagia Rehabilitation Via The Synergistic Effects of Neuromuscular Electrical Stimulation, Neuromuscular Taping, and Swallowing Exercises: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the effects of a combined swallowing intervention (Neuromuscular Electrical Stimulation (NMES) + Neuromuscular Taping (NMT) + swallowing exercises) on swallowing function and quality of life in post-stroke dysphagia patients. The main questions it aims to answer are: • Does the combination of swallowing exercises, NMES \& NMT have a greater improvement in dysphagia rehabilitation when compared to either NMES or NMT alone? Researchers will compare the effects of intervention between the three groups (NMES and swallowing exercises, NMT and swallowing exercises, … |
HAMAD MEDICAL | 2024-11-01 |
| 252 | Effects of Vestibular Rehabilitation on Balance and Post Stroke Fatigue: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to determine the effects of stroke conventional therapy compared with the effects of vestibular rehabilitation therapy on balance and post stroke fatigue. The study will be randomized control trial including 2 experimental groups with estimated 28 individual in each group |
NADIA AZHAR MS-NMPT; | 2024-11-01 |
| 253 | The Safety and EffiCacy of HIbernation-Like Therapy Combining RecanaLization in Ischemic Stroke: A Phase 1, Dose-escalation Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn whether chlorpromazine and promethazine（C+P）is safe in Acute Ischemic Stroke（AIS) patients and determine the maximum dosage. It will also evaluate the preliminary efficacy of C+P in AIS. The main questions it aims to answer are: What is the optimal dosage of C+P that is safe without causing adverse effects in AIS patients? What is the optimal dosage of C+P that potentially works to treat AIS? Researchers will compare C+P with placebo (saline solution without C+P) to see if C+P is safe and effective in treating Acute Ischemic Stroke. Participants will: Receive C+P or placebo at the same time as endovascular thrombectomy begins. Patients will be observed for 72 hours to see if there were any adverse effects related to C+P. Infarct volumes will be evaluated using Computed Tomography. Functional outcomes will be assessed at 90 days. |
JI XUNMING; | 2024-11-01 |
| 254 | Reference Values and Determinants of 6-minute Walk Test Distance in Turkish Patients With Chronic Stroke: A Multicenter Cross-sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The first aim of this study was to investigate the reference values of 6-minute walk test (6MWT) distance in patients with chronic stroke. The second aim was to determine the factors predicting 6MWT distance in patients with chronic stroke. |
MERVE ÖRÜCÜ ATAR; | 2024-10-30 |
| 255 | Effects of Dual-Task and Progressive Wall Squat Training on Cognition, Balance and Functional Mobility in Stroke Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the Effects of Dual-Task and Progressive Wall Squat Training on Cognition, Balance and Functional mobility in Stroke Survivors. |
ARUBA SAEED; | 2024-10-30 |
| 256 | The Effect of Task-oriented Training With Conventional Rehabilitation on Upper Extremity Motor Functions in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of our study was to investigate the effects of task-oriented training added to conventional rehabilitation on upper extremity muscle thickness and upper extremity motor functions. |
GUZIN KAYA AYTUTULDU; | 2024-10-30 |
| 257 | The Effects of Transcranial Direct Current Stimulation and Cognitive Behavioural Programme on Post-stroke Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effect of transcranial direct current stimulation and cognitive behavioural programme on fatigue and its related outcomes among people with stroke. |
SHAMAY NG; | 2024-10-28 |
| 258 | Prognostic Biomarkers for Selective Intra-Arterial Cooling Infusion Combined with Endovascular Thrombectomy in Acute Ischemic Stroke Based on Proteomics and Metabolomics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Endovascular Thrombectomy has emerged as a pivotal treatment modality for acute ischemic stroke. However, despite successful thrombus removal, a substantial proportion of patients still experience poor outcomes. Selective intra-arterial cooling has shown promise in decelerating stroke progression and providing neuroprotection. This study aims to identify biomarkers associated with the combination of selective intra-arterial cooling infusion and endovascular thrombectomy in the treatment of ischemic stroke by integrating proteomics and metabolomics data. Our study is based on the multicenter RCT study Safety and Efficacy of Selective Intra-Arterial Cooling Infusion Combined With EVT in Acute Ischemic Stroke. All samples were derived from this experiment. Our objective is to elucidate the molecular mechanisms underlying the prognostic impact of this combined therapeutic approach, providing insights to optimize stroke treatment strategies. |
JI XUNMING; | 2024-10-27 |
| 259 | Evaluation of A Locally Adapted Stroke Unit to Improve Outcomes in Lusaka, Zambia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the impact of a locally adapted stroke unit on outcomes of adults with stroke in Zambia. The main question\[s\] to answer are: • Does provision of evidence-based stroke care improve after implementation of a stroke unit at the University Teaching Hospital in Zambia? • Do patients cared for in a locally adapted stroke unit at the University Teaching Hospital in Zambia have better in-hospital and post-discharge outcomes that similar patients who were not cared for in the stroke unit? The investigators will collect data on the types of care participants receive during hospitalization and vital status (alive/dead) at the time of hospital discharge and at 90-days post-discharge. Researchers will compare patients enrolled in this study to a historical group of adults with stroke cared for at the same hospital prior to implementation of the stroke unit. |
DEANNA SAYLOR; | 2024-10-25 |
| 260 | Effects of Transcranial Direct Current Stimulation on Post Stroke Depression PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the research is to address the critical gap that limited number of RCTs are conducted on this topic. To further explore the efficacy of tDCs, large sample sizes, large follow up period and rigorously controlled randomized clinical trials are necessary. An optimum stimulation protocol is also needed on this study. Previous studies lack information regarding effects of this stimulation on depression, cognition, quality of life in relation to different severity levels of stroke. |
MIRZA OBAID BAIG; | 2024-10-25 |
| 261 | Effect of Balance, Resistance, Aerobic, Cognitive Exercises(BRACE)on Balance, Cognition and Mobility Among Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Objective of the is to determine effect of balance, resistance, aerobic, cognitive exercises (BRACE) protocol on balance, cognition and mobility among stroke patients and to compare the effect of Balance, Resistance, Aerobic, and Cognitive Exercise (BRACE) and task-oriented training on balance cognition and mobility in stroke patients. The study will be randomized control trial including 2 experimental groups with estimated 21 individual in each group. |
NADIA AZHAR; | 2024-10-24 |
| 262 | Effects Of Tai Chi Exercises With Cycling Exercises On Balance, Gait And Quality Of Life In Sub-Acute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke, a debilitating cerebrovascular event, frequently leads to severe motor and sensory impairments resulting in a diminished quality of life. Tai Chi, an ancient Chinese martial art known for its slow, flowing movements, emphasis on breath control, and mindfulness, presents an intriguing avenue for stroke rehabilitation. While cycling exercises facilitates muscle control of the lower limbs, which may allow putting more weight on the affected leg while standing, also beneficial for stroke survivors. |
MUHAMMAD ASRAR YOUSAF; | 2024-10-24 |
| 263 | Taiwan Post-Stroke Disability Study (T-PODS): A Survey of Multiple Post-Stroke Disability Domains Among Stroke Patients in Taiwan PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke remains a major health issue in Taiwan, being the fourth leading cause of death and the top cause of disability. While past research has focused on functional outcomes at three months post-stroke, stroke can cause a range of disabilities in areas such as motor function, swallowing, cognition, depression, and epilepsy. This study will investigate these disabilities by enrolling 2,000 acute stroke patients (both ischemic and hemorrhagic) from 10 medical centers across Taiwan. Data will be collected at three key points: at enrollment, three months, and twelve months post-stroke, using surveys, assessments, imaging, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2024-10-21 |
| 264 | Pericardiotomy in Cardiac Surgery Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery. |
RICHARD WHITLOCK; | 2024-10-21 |
| 265 | PHARMACOGENETIC ALGORITHM FOR WARFARIN DOSE PREDICTOR: PROTOCOL FOR IMPROVEMENT AND EFFECTIVENESS OF THERAPY ANTICOAGULANT PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Atrial Fibrillation (AF) is the most common supraventricular arrhythmia in clinical practice. The presence of AF, as an independent factor, increases mortality by up to two times. One in every six cerebrovascular accidents (CVA) occurs in patients with AF, generating an annual risk of around 7% per year, which represents an increase of up to seven times in relation to the risk in the general population, leading to the need for start anticoagulant therapy. Warfarin is still the Oral Anticoagulant (OC) of choice, … |
UNIVERSITY OF PERNAMBUCO | 2024-10-21 |
| 266 | Efficacy and Safety Study of Endovascular Treatment of Asymptomatic Carotid Artery Stenosis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter, prospective, open-label, endpoint-blinded, randomized controlled trial designed to evaluate the safety and efficacy of endovascular stenting combined with optimal medical therapy versus optimal medical therapy alone in patients with asymptomatic severe stenosis (70-99%) of the internal carotid artery. The study plans to enroll 982 patients aged 40-80 years who have had no ipsilateral carotid artery-related neurological symptoms in the past six months and who have declined carotid endarterectomy. The primary endpoints include stroke, myocardial infarction, or death within 30 days post-procedure/enrollment, … |
FENG GAO; | 2024-10-18 |
| 267 | A Prospective, Open-label Study Evaluating The Effects of Probucol Combined with Statins on Atherosclerotic Characteristics and Prognosis in Patients with Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate whether the combination of Probucol with statin therapy can reduce the risk of vascular events and improve atherosclerosis outcomes in adults with ischemic stroke and confirmed atherosclerosis. The main questions it aims to answer are: Does adding Probucol to statin therapy reduce plaque burden more effectively than statins alone? Does the combination therapy lead to fewer cardiovascular and cerebrovascular events compared to statins alone? Researchers will compare participants receiving standard statin therapy to those receiving statins combined with Probucol to assess differences in plaque burden and the occurrence of vascular events. Participants will: Choose either standard statin therapy (with possible addition of ezetimibe or PCSK9 inhibitors) or the same therapy combined with Probucol 0.5g twice daily. Attend regular follow-up visits for monitoring atherosclerosis features and cardiovascular health over a 3-year period. Undergo imaging studies to evaluate changes in atherosclerosis and blood tests to monitor lipid levels and other biomarkers. |
XIN MA; | 2024-10-17 |
| 268 | Comparative Effects of Resistance Training and Constrained Induced Movement Therapy on Upper Extremity Motor Recovery and Quality of Life in Sub-acute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study explored two common rehabilitation strategies-Constraint-Induced Movement Therapy (CIMT) and Resistance Training (RT)-to help stroke survivors improve movement and function in their weaker arm. Stroke can often lead to reduced mobility in one arm, … |
HAFIZA ZOHA MUSHARAF; | 2024-10-15 |
| 269 | Effects of Robotic Gloves Along With Task-oriented Mirror Therapy on Motor Functions of Hands in Sub-acute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is randomized control trial and purpose of this study is to find effects of robotic gloves assisted task-oriented mirror therapy in comparison with task-oriented mirror therapy on motor functions of hand in sub-acute stroke patients. |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-10-12 |
| 270 | Perceptions of Using RehAtt Mixed Reality System in Stroke Motor Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to explore the patients’ perspective on usability and feasibility of the RehAtt™ mixed-reality system during upper limb, gait and balance function rehabilitation. |
NATAŠA BIZOVIČAR; | 2024-10-11 |
| 271 | Regular Physical Activity in Patients With Symptomatic Intracranial Arterial Stenosis: A Prospective Randomized Open-label Blinded Endpoint Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the effectiveness and safety of regular physical activity in preventing ischemic stroke events in patients with symptomatic intracranial arterial stenosis. |
JI XUNMING; | 2024-10-10 |
| 272 | Safety and Effectiveness of Short-Term Single AntiPlatelet Therapy After Left Atrial Appendage Closure With The LAmbre Device in Patients With Nonvalvular Atrial Fibrillation: A Multinational Real-world Registry PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Brief Summary: A prospective, multicenter, single-arm, non-randomized study including consecutive patients with nonvalvular AF(Atrial Fibrillation), with a CHA2DS2-VASc score ≥2 (men) or ≥3 (women), and contraindication for long-term anticoagulant treatment, with successful LAAC (Left Atrial Appendage Closure)procedure with the LAmbre device, who at discharge are eligible for short-term (3-months-only) SAPT. We want to assess if a short-term single antiplatelet therapeutic regime of Acetylsalicylic acid (ASA) 100 mg (or clopidogrel 75 mg if ASA contraindication), once daily, for 3 months is safe and effective at 12 months follow-up. |
FUNDACIÓN EPIC | 2024-10-10 |
| 273 | Effetto Della DIETa MEdiTerranea Sull’Incidenza Di Ictus E Sul Decadimento Cognitivo in Pazienti Affetti Da Cadasil E Angiopatia Cerebrale Amiloide PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is divided into two phases: Phase 1 (observational) and Phase 2 (dietary intervention). The goal of Phase 1 is to assess the nutritional status and dietary habits of two cohorts of patients with CADASIL and CAA. A specific aim is to evaluate adherence to the Mediterranean Diet. The objectives include analyzing patients’ nutritional status, lean and fat mass, basal metabolism, and total energy expenditure. It also aims to assess the relationship between adherence to the Mediterranean Diet and the onset of stroke and cognitive decline, … |
FONDAZIONE I R C C S ISTITUTO NEUROLOGICO CARLO BESTA | 2024-10-10 |
| 274 | Effect of Russian Current Stimulation for Anterior Tibial Group on Postural Stability and Risk of Falling in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to examine the effect of Russian current stimulation on Anterior tibial group on postural stability and risk of falling in patients with stroke. |
ABDELRAHMAN REFAAT MOHAMED; | 2024-10-10 |
| 275 | The Relationship of Ultrasonographic Parameters Used in The Evaluation of Dysphagia in Stroke Patients With Swallowing Severity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ultrasonographic parameters in stroke patients with dysphagia |
CANSIN MEDIN; | 2024-10-01 |
| 276 | Demonstration of The Relationship Between Mimic Muscle Volume and Central Facial Palsy Severity and Dysphagia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 70 stroke patients with central facial paralysis will be included and their demographic data will be questioned and facial nerve thickness, depressor labi inferior, depressor anguli oris, buccinator and risorius muscles will be evaluated. |
ISTANBUL PHYSICAL MEDICINE REHABILITATION TRAINING AND RESEARCH HOSPITAL | 2024-10-01 |
| 277 | Effects Of Transcranial Direct Current Stimulation On Spasticity In Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Multiple research has worked on tDCS and its impact on stroke. But none have studied the effects of tDCS on stroke in relation to the different stages of stroke like mild, moderate, moderate to severe and severe stroke as per national institute of health (NIH) scale. Additionally, this study will be conducted to address the few drawbacks in previous studies such as short follow up period by employing evidence based standardized protocols. It can potentially instigate the efficacy of tDCS on spasticity, motor recovery and Quality of life in relation to the different severity levels of stroke. |
MIRZA OBAID BAIG; | 2024-10-01 |
| 278 | Brain Activation Pattern Caused By Immersive Virtual Reality Pathfinding Task in Stroke Patients: A Functional Near-infrared Spectroscopy Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an fNIRS study performed to investigate Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients. |
DINGQUN BAI; | 2024-10-01 |
| 279 | Combined Effect of Constraint Induced Movement Therapy and Brunnstrom Movement Therapy on Upper Extremity Spasticity, Motor Activity and Quality of Life in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a leading cause of disability characterized by inadequate blood supply to the brain, leading to cell death and neurological deficits. Motor impairment of the upper extremity is a common consequence among stroke patients, … |
SABIHA ARSHAD; | 2024-10-01 |
| 280 | TRIal to Evaluate TraNsvenous TrIcuspid Valve ReplacemenT with LuX-Valve Plus System in Patients with Severe or Greater Tricuspid Regurgitation – SafetY and Clinical Performance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The LuX-Valve Plus System is intended for the treatment of patients with at least severe TR who are symptomatic and determined by a Heart Team not to be suitable for surgical treatment. This study aims to assess the safety and effectiveness of the LuX-Valve Plus System in high-surgical risk patients with at least severe tricuspid regurgitation (TR). |
JENSCARE INNOVATION | 2024-09-26 |
| 281 | A Multicenter, Prospective, Single-arm, Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this PMCF study is to: – confirm the safety and performance of the AcuMarkTM Sizing Balloon – identify previously unknown side-effects – monitor the identified side-effects (related to the procedure or to the medical devices) |
LIFETECH SCIENTIFIC SHENZHEN | 2024-09-24 |
| 282 | The SDOH-Homecare Intervention Focus Team (SHIFT) Trial to Mitigate Social Determinants of Stroke Outcomes and Build Community Capacity (The SHIFT Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Goal: To test the hypothesis that among stroke patients 18-75 years with ≥3 SDOH risk factors, SHIFT will improve: (1) functional outcomes as measured by the SIS (Primary Outcome), (2) physiological outcomes as measured by changes in blood pressure and cognition, (secondary outcomes) and (3) epigenetic allostatic load biomarkers (exploratory outcome) such as DNA methylation (DNAm) and telomere length, at 6 months and 1-year post-stroke, compared with usual care (UC). |
OLAJIDE WILLIAMS; | 2024-09-17 |
| 283 | The TRICURE EFS TRiCares Topaz Transfemoral TRICUspid Heart Valve REplacement System Early Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective, multi-center study to assess safety and performance of the TRiCares Topaz Tricuspid Valve Replacement System |
SUSHEEL KODALI; | 2024-09-11 |
| 284 | Task Oriented Mirror Therapy for Upper Limb Motor Function in Stroke Patient PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke remains a major public health disease worldwide ,it usually associating with damage to the motor function and other functional disabilities. Persistent upper extremity dysfunction affects many post strokepatients and is strongly associated with decreased activities of daily living . Mirror therapy one of the rehabilitation that is beneficial for neuroplasticity .This therapy is used to improve motor function after stroke . |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-09-10 |
| 285 | Motor Imagery Training for Upper Limb Functional Strength in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a leading cause of upper extremity deficits worldwide. Persistent upper extremity dysfunction affects many post stroke patients and is strongly associated with decreased activities of daily living and poor quality of life. There is accumulating evidence of a cross-over effect with training of one limb that slightly increase strength and coordination in contralateral untrained limb through neurological adaptations. One of rehabilitation that is beneficial for stroke patient is motor imagery, … |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-09-10 |
| 286 | Evaluation of Predictive Circulating Biomarkers for Rehabilitation Recovery in Ischemic and Haemorrhagic Stroke Patients: from Lacunar Stroke to Vascular Severe Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The rehabilitation outcome and recovery, in people after stroke or with vascular severe brain injury(vSBI), are difficult to predict. Moreover, the clinical management of patients during hospitalization is problematic due to complex clinical conditions and complications, e.g. healthcare-associated infections(HAIs). Today we still lack early objective biomarkers that could predict the patient’s trajectory at admission. Extracellular vesicles are nanoparticles naturally released by cells in physiological and pathological conditions. As important actors of cellular communication between different organs and body districts, … |
ALICE GUALERZI; | 2024-09-09 |
| 287 | Impact of Basophobia on Balance and Functional Outcomes in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Several studies have reported that the physical functions associated with falls, including motor performance, postural balance, flexibility, and muscle strength, are also associated with FoF. Patients with stroke have trouble performing ADLs, including washing their face, eating, bathing, dressing, toileting, and walking, which also affect FoF. Anxiety and depression are common affective disorders in patients with stroke and significantly increase FoF . |
HEBA MOHAMED GABER; | 2024-09-09 |
| 288 | Impact of The BOOST GAIT Program on Gait Recovery and Functional Mobility After Stroke – A Pilot Study Impact Van Het BOOST GAIT Programma Op Het Herstel Van Het Gangbeeld En Functionele Mobiliteit Na Een Beroerte – Een Pilootstudie PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overarching goal is to determine if the BOOST GAIT program can improve functional mobility in patients with stroke who are undergoing inpatient rehabilitation and have some walking function, through the application of augmented therapeutic exercises designed to achieve a normative gait pattern. The evaluation will be conducted using a combination of clinical scales and objective motion sensors that map walking quality and performance during activities of daily living, such as rising from a chair and standing. It is acknowledged that this single-group pilot study, which aims to include 12 participants, … |
PETER FEYS; | 2024-09-02 |
| 289 | Association Between Blood Pressure and The Risk of Post-stroke Cognitive Impairment: A Retrospective Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This retrospective cohort study was designed to explore the relationship between blood pressure and cognitive impairment after stroke |
DINGQUN BAI; | 2024-09-01 |
| 290 | Correlation Between Optic Nerve Sheath Diameter Measured By POCUS and Neurological Deficit in Physical Examination in Adult Patients with Suspected Ischemic Stroke Evaluated in Emergency Departments PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The ultrasound of the optic nerve sheath diameter (ONSD) is a non-invasive tool used in the detection of intracranial hypertension and other neurological conditions. The aim of this research is to evaluate the correlation between the ultrasound measurement of the optic nerve sheath diameter and the side of neurological focus in the physical examination of adult patients evaluated in emergency departments. |
CLINICA MEXICO | 2024-09-01 |
| 291 | Validation And Turkish Cross-Cultural Adaptation of Stroke Knowledge Test PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebrovascular diseases are the leading cause of disability, work loss, and quality of life reduction, the third leading cause of death globally, and significantly impact hospital admissions and expenses. This prevalence rises with an aging population and comorbidities. Recognizing stroke symptoms quickly is crucial for timely treatment. Miscommunication or misunderstanding among hypertensive patients, who are at the highest risk for stroke, increases stroke risk and complications. Educating the public about stroke symptoms and responses is essential for prevention. Therefore, … |
FURKAN ÇAKIR; | 2024-09-01 |
| 292 | Effects of The Individual and Family Self-Management of Fall Prevention Program on Balance Ability and Fall Efficacy Among Chinese With Post-Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is about exploring the effectiveness of individual and family self-management (IFSM) fall prevention programs on balance ability and fall efficacy in post-stroke people. The main intervention measures were developed based on the risk and protective factors of fall prevention in post-stroke people, including exercise, environment safety, assistant technology, medication review, and safety in daily activities. The intervention will be implemented in 10 weeks for both patients and their family members. By mastering these skills, post-stroke people may reduce the number of falls after discharge to home. |
WANG YINHUA; | 2024-09-01 |
| 293 | Development of Compensation-Based Problem Solving Therapy (CBPST) and Investigation of Its Effects on Individuals with Stroke : A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to develop a Compensation-Based Problem-Solving Therapy and to examine its effects on activities of daily living, participation, self-efficacy, and quality of life in individuals with stroke. |
LEYLA KAYA OZTURK; | 2024-09-01 |
| 294 | Comparative Study of The Mechanism of Action of Dry Needling and Botulinum Toxin Type A As A Treatment for Lower Limb Post-stroke Spasticity: A Proof of Concept Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized parallel group clinical trial which will be conducted in three countries (Spain, Canada and Belgium) comparing Botulinum Toxin type A (BTX-A) and Dry Needling (DN) effectiveness for post-stroke spasticity in participants who had a first stroke in the previous 12 months and have plantar flexor spasticity. Participants will be randomly allocated to receive either one session of BTX-A or 12 weekly sessions of DN. Blinded evaluators will assess the effects before, during, and after treatment, and at a 4-week follow-up. |
PABLO HERRERO GALLEGO; | 2024-09-01 |
| 295 | The TRICURE EU PIVOTAL TRiCares Topaz Transcatheter TRICUspid Heart Valve REplacement System EUropean PIVOTAL Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective, multi-center study to assess safety and performance of the TRiCares Topaz Tricuspid Valve Replacement System |
JÖRG HAUSLEITER; | 2024-08-29 |
| 296 | Turkish Validity and Reliability of The Expanded Rehabilitation Complexity Scale in Patients in The Stroke Palliative Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The RCS is a tool that can assess the need for complex rehabilitation and objectively indicate that a patient may have difficulty functioning well at home or in the community if their medical needs are still high. Among rehabilitation patients, there are still patients with complex needs, even though they have maximized rehabilitation potential. Moreover, RCS can also be useful in highlighting cases of patients becoming seriously ill during the rehabilitation process due to an acute illness such as sepsis, which significantly limits treatment time. This information can be emphasized using RCS data when requesting extended or increased rehabilitation support. |
SEDEF ERSOY; | 2024-08-24 |
| 297 | Correlation Between Clinical Assessment and Neurophysiological Assessment in Spinal Cord Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a cross-sectional study that aims to explore the correlation between clinical assessment and neurophysiological assessment in SCI. The clinical outcome assessment are modified-Modified Ashworth scale (m-MAS) and lower extremity motor score. The neurophysiological outcome is H-reflex outcome. |
MAHIDOL UNIVERSITY | 2024-08-23 |
| 298 | Comparative Efficacy of Amlodipine Folic Acid Vs. Amlodipine on The Risk of First Ischemic Stroke Among Participants with Hypertension and MTHFR 677 TT Genotype: A Multi-center, Randomized, Double-blind, Triple-dummy, Controlled Clinical Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, double-blind, triple-dummy, controlled trial in 24,000 Chinese men and women with hypertension and MTHFR 677 TT genotype. The study participants will be randomized to one of the three treatment groups: Group A: amlodipine tablet (5mg), taken orally, once daily, serving as active comparator. Group B: amlodipine folic acid 5.8mg tablet (5mg amlodipine and 0.8mg folic acid), taken orally, once daily. Group C: amlodipine folic acid 5.8mg tablet plus 5-methyltetrahydrofolate (5-MTHF, 0.4mg), taken orally, once daily. The primary endpoint is first ischemic stroke. |
JIANPING LI; | 2024-08-22 |
| 299 | Comparative Efficacy of Amlodipine Folic Acid Vs. Amlodipine on The Risk of First Ischemic Stroke Among Participants with H-type Hypertension and MTHFR 677 CC/CT Genotype: A Multi-center, Randomized, Double-blind, Double-dummy, Controlled Clinical Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, double-blind, double-dummy, controlled clinical trial. This trial will include 32,000 Chinese men and women with hypertension (H-type hypertension), MTHFR 677 CC or CT genotype, elevated plasma total homocysteine (tHcy ≥10µmol/L), and insufficient serum folate levels (\<12ng/mL). The participants will be first stratified by their MTHFR 677 genotype (CC vs. CT), then randomized to one of two treatment groups in a 1:1 ratio. Group A: amlodipine tablet (5mg), taken orally, once daily, serving as active comparator. Group B: amlodipine folic acid 5.8mg tablet (5mg amlodipine and 0.8mg folic acid), taken orally, ... |
YONG HUO; | 2024-08-22 |
| 300 | Cognitive Priming to Boost Stroke Tele-rehabilitation Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot study is to investigate whether adding cognitive rehabilitation to an existing occupational therapy (OT) stroke telerehabilitation program will improve stroke survivors’ functioning. The main question it aims to answer is whether this intervention improves cognition, participation, upper extremity use in real-world activities, and mood/quality of life. Participants will be asked to engage in an 8-week stroke tele-rehabilitation program (13 sessions), which includes both cognitive rehabilitation and OT for arm/hand function, and complete assessments before and after the intervention. |
STEPHANIE AGHAMOOSA; | 2024-08-20 |
| 301 | Powering Up Stroke Rehabilitation Through High-Intensity Interval Training PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: To investigate the effects of high-intensity interval training (HIIT) on musculoskeletal fitness in chronic stroke survivors. Hypothesis to be tested: HIIT, performed on a recumbent stepper, will significantly enhance muscle power in chronic stroke survivors when compared with moderate-intensity continuous training (MICT) Design and subjects: Assessor-blinded, stratified, randomised, placebo-controlled clinical trial involving eligible 66 chronic stroke survivors. Interventions: Participants will be randomly allocated to one of three groups: the HIIT group, the MICT group, or a stretching group (active control). Each group will attend sessions three times per week for 12 consecutive weeks, … |
THE HONG KONG POLYTECHNIC UNIVERSITY | 2024-08-20 |
| 302 | Detecting Cardiac Thrombi in Acute Ischemic Stroke on Cardiac CT Versus Transoesophageal Echocardiography (MtH-DETECT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Cardiac CT acquired during the acute stroke imaging protocol (acute cardiac CT) has recently been shown to have a superior diagnostic yield than transthoracic echocardiography, which is currently the most commonly used method to screen for structural sources of cardioembolism in patients with acute ischemic stroke. The most common finding on acute cardiac CT are cardiac thrombi located in the left atrium (LA) and specifically the left atrial appendage (LAA). The higher diagnostic yield of acute cardiac CT compared to TTE is partially explained because CT allows for better visualization of the LAA, … |
JONATHAN COUTINHO; | 2024-08-19 |
| 303 | Individualized Stroke Risk Scores and Hemostatic Profile in Oral Anticoagulant-naïve (OAC-naïve) Patients With Non-valvular Atrial Fibrillation (NVAF) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Atrial fibrillation (AF) is the most common heart rhythm disorder worldwide. Globally, there are 37.5 million people with AF. AF increases the risk of death, heart failure, and stroke, which severely affect patients and also lead to high healthcare costs. Around 25% of all strokes are caused by AF, and patients with stroke due to AF tend to have a higher risk of death and more disability compared to stroke patients without AF. Stroke prevention is, therefore, an important part of AF treatment, in which blood thinning medication has an important role. However, … |
NEDIM TOJAGA; | 2024-08-16 |
| 304 | Effects of Prolonged and Chronic Critical Illness Induced By Brain Injury on Metabolic State: Matched Case-control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Brain injuries, including acute stroke (AS) and traumatic brain injury (TBI), are prevalent pathologies with severe consequences. Cerebral infarction accounts for 65-85% of AS cases, while hemorrhagic stroke, though less common, has a higher mortality rate (30-50%) and limited recovery (10-20%). TBI is a significant medical and socioeconomic issue due to its high prevalence, severe consequences, and the high rates of temporary and permanent disability, particularly among young and working-age adults. The average mortality rate for severe TBI is 39%, with 60% facing unfavorable outcomes according to the Glasgow Outcome Scale. High levels of permanent disability, … |
ALEXANDER SHESTOPALOV; | 2024-08-15 |
| 305 | The Effect of Talocrural Joint Manipulation on Static Balance in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of the study is to investigate the effect of talocrural joint manipulation on the static balance of patients with stroke. The secondary aim of this study is to investigate the effect of talocrural joint manipulation on the dorsiflexion range of motion of patients with stroke. |
OMER DURSUN; | 2024-08-15 |
| 306 | Early Feasibility Study of The DUO Transcatheter Tricuspid Coaptation Valve System in Patients With Tricuspid Regurgitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is an early feasibility study to measure individual patient clinical outcomes and effectiveness, evaluate the safety and function of the DUO Transcatheter Tricuspid Coaptation Valve System (DUO System). |
CROIVALVE | 2024-08-13 |
| 307 | Unraveling The Multidimensional Functional Recovery Patterns and Prognostic Factors in Post-Discharged Stroke Survivors: A Retrospective Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare the 1-year recovery trajectories of multidimensional functional recovery among stroke survivors after discharge from hospital care. To address this purpose, a retrospective analysis will be conducted using clinical data from two independent cohorts derived from previously published prospective observational studies. The study will conduct generalized estimating equations and mixed-effects regression models to assess differences in recovery trends among stroke subgroups. The findings will provide detailed profiles of longitudinal changes in functional outcomes one year after discharge from hospital care. These results will clarify how stroke subtypes influence long-term functional outcomes and will guide the development of targeted interventions. |
FENG-HANG CHANG; | 2024-08-12 |
| 308 | Rehabilitation With and Without Robot and Allied Digital Technologies (RADTs) in Stroke Patients: A Pragmatic Multicenter Randomised Controlled Trial on The Effectiveness, Acceptability, Usability, and Economic-organizational Sustainability of RADTs From Subacute to Chronic Phase PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Rehabilitation after stroke often employs Robot and Allied Digital Technologies (RADTs), yet evidence on their effectiveness remains inconclusive due to study heterogeneity and limited sample sizes. This multicentre randomized controlled pragmatic trial aims at comprehensively and accurately assessing the effectiveness of rehabilitation mediated by RADTs after a stroke, compared to traditional rehabilitation, also considering economic sustainability. |
IRENE G APRILE; | 2024-08-12 |
| 309 | Predictive Role of Early Blood KLK10 and Other Neuroinflammatory Molecules on Clinical Outcomes of Acute Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the dynamic changes and differential expression characteristics of neuroinflammatory molecules such as kallikrein-related peptidase 10 (KLK10), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), and glial fibrillary acidic protein (GFAP) in the plasma of patients with first-ever anterior circulation acute ischemic stroke (AIS). It will analyze the correlation between these molecules and the severity of neurological deficits, infarct volume, brain edema, hemorrhagic transformation, progressive stroke, and clinical outcomes at three months. The goal is to assess the predictive value of these molecules for AIS prognosis, … |
LI LONGXUAN; | 2024-08-12 |
| 310 | Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Reperfusion Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the effectiveness and safety of endovascular therapy combined with 25% human albumin in the treatment of acute large vessel occlusive stroke. |
JI XUNMING; | 2024-08-10 |
| 311 | Multiple Effects of Dual-Task Focused Training in Individuals with Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to comprehensively investigate dual-task-focused training on balance, functionality, anxiety, healthy function and quality of life in chronic individuals. Stroke is a clinical condition that occurs as a result of deaths in the brain blood and is an important public health problem, ranking third among the causes of death in the world and first among the diseases that cause disability. There are a limited number of studies in the literature investigating the effectiveness of dual task training in stroke rehabilitation. |
YASEMIN ŞAHBAZ; | 2024-08-10 |
| 312 | Ultrasonographic Evaluation of Parasternal Intercostal Muscles and Their Correlation With Respiratory Function Test in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ultrasonographic evaluation of parasternal intercostal muscles and to determine whether there is a correlation with PFT parameters in stroke patients |
YUNUS EMRE DOGAN; | 2024-08-07 |
| 313 | Safety, Tolerability, and Preliminary Efficacy of HRS-7450 Injection in The Treatment of Acute Ischemic Stroke: A Multi-center, Randomized, Double-blind, Double-dummy, Placebo-controlled, Single Dose Incremental Phase Ib Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-center, randomized, double-blind, double-dummy, placebo-controlled, single dose escalation study aimed at evaluating the overall safety, tolerability, and preliminary efficacy of HRS-7450 in patients with acute ischemic stroke. |
FUJIAN SHENGDI PHARMACEUTICAL | 2024-08-06 |
| 314 | Effect of In-hospital Initiation of PCSK9i on Clinical Outcomes in Chinese ACS Patients: A Database-based Retrospective Analysis PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to investigate the effectiveness of in-hospital initiation of alirocumab combined with statin ± ezetimibe on major cardiovascular events (MACE) in Chinese ACS patients. The main question it aims to answer is: whether early initiation PCKS9i in hospital could reduce recent cardiovascular event risk in Chinese ACS patients in real-world setting. Data from CCA Database-Chest Pain Center were screened for all ACS patients from 01-Jan 2021 to 31-Dec 2023. Patients diagnosed with STEMI, NSTEMI or UA at admission were identified at the first step. Then, for intervention group, … |
YUN DAI CHEN; | 2024-08-01 |
| 315 | Brain Computer Interface (BCI) Integrated Wearable Hand Robotic Glove System for Upper Limb Stroke Rehabilitation: A 3-arm Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Upper extremity (UE) recovery remains a huge rehabilitation challenge with largely incomplete recovery of the upper limb post stroke. This is due to heavier priorities placed on other stroke competencies such as mobility, activities of daily living training and home integration which results in suboptimal amounts of time spent in upper limb training post stroke. In this study the investigators plan to pilot brain computer interface (BCI) integrated wearable hand robotic glove (HandyRehab) system for upper limb stroke rehabilitation. |
KAREN CHUA; | 2024-08-01 |
| 316 | The Effectiveness of Anti-spastic Splint With Added Focal Muscle Vibration (FMV) in Decreasing Hand Spasticity and Improving Hand Functionality Among Individuals With Chronic Stroke: A Pilot Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Title: The Effect of Vibrating Splint on Hand Function After Stroke Summary: This study aims to investigate the effectiveness of a vibrating splint in improving hand function and reducing spasticity among individuals who have experienced a stroke. Stroke is a major global health issue, often resulting in long-term disability and impairments in the upper limbs. Spasticity, a common complication of stroke, causes stiffness and involuntary muscle contractions, leading to difficulties in performing daily activities. Current treatment options for spasticity include medications and physical therapy techniques. However, these approaches may have limitations in terms of effectiveness and duration of benefits. Therefore, … |
AMER JAROSHY; | 2024-08-01 |
| 317 | Identifying Biomarkers Related to Post-stroke Cognitive Impairment: A FNIRS Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an fNIRS study performed to identify biomarkers related to post-stroke cognitive impairment. |
DINGQUN BAI; | 2024-08-01 |
| 318 | Long-Term Follow-up Study of ROADSTER 3 Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study objective is to evaluate long-term outcomes for participants enrolled in the ROADSTER 3 study and treated with the ENROUTE Transcarotid Stent System (TSS) and ENROUTE Transcarotid Neuroprotection System (NPS). |
MEGHAN DERMODY; | 2024-07-31 |
| 319 | A Multicenter, Double-blinded, Placebo-controlled, Single Ascending Dose, Two-part, Randomized, Phase 2 Clinical Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BB-031 in Acute Ischemic Stroke Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and tolerability of ascending doses (Part A) and selected doses (Part B) of BB-031 in acute ischemic stroke patients presenting within 24 hours of stroke onset. Participants will be randomized to receive one dose of either the investigational drug or placebo and will be followed for 90 days. A total of 156 patients are planned in this study. |
MICHAEL D HILL; | 2024-07-31 |
| 320 | Home RehabGym: A Qualitative and Usability Evaluation of Advanced Technologies for Home Upper Limb Neurorehabilitation Post-stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Due to limited resources such as the low therapist to patient ratio or high costs associated to rehabilitation therapy, providing higher therapy dose to patients after discharge is highly challenging. This often results in non-use of the impaired limb as a result of the decreased therapy dose, causing partial loss of the functional improvements previously gained during early rehabilitation. In this study, the investigators plan to pilot the HomeRehab Gym concept via the deployment of three rehabilitation devices at patients’ homes: MyoPanda, H-Man and ReHandyBot. |
KUAH WEE KEONG CHRISTOPHER; | 2024-07-31 |
| 321 | Comorbidities and The Management of Hypertensive Heart Disease in A Low-Resource Setting: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this Cross-sectional study, we will analyzed data from a tertiary referral Congolese hospital to find whether or not Congolese patients with hypertensive heart disease have multiple comorbid conditions. Will report on the management and outcomes of the patients. |
RAÏSSA K KONGUE; | 2024-07-26 |
| 322 | Emergency Stroke Unit for Acute Cerebrovascular Events–A Prospective, Multicenter, Week-wise Randomized, Controlled Trial ( ESU-ACE-A ) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the door-to-needle time of patients with hyperacute ischemic stroke (within 4.5 hours after the onset of symptoms) managed in a standard stroke unit adherent to guidelines versus managed in Emergency Stroke Unit (a new stroke unit based on low-field magnetic resonance imaging). |
YONGJUN WANG; | 2024-07-26 |
| 323 | Emergency Stroke Unit for Acute Cerebrovascular Events–A Prospective, Multicenter, Week-wise Randomized, Controlled Trial ( ESU-ACE-B ) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the door-to-puncture time of patients with hyperacute ischemic stroke (between 4.5-6 hours after the onset of symptoms) treated in a standard stroke unit adherent to guidelines versus treated in Emergency Stroke Unit (a new stroke unit based on low-field magnetic resonance imaging). |
YONGJUN WANG; | 2024-07-25 |
| 324 | Oral Anticoagulation Versus Left Atrial Appendage Occlusion Added to Direct Oral Anticoagulation in Patients with Stroke Despite Oral (ADD-LAAO TRIAL) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A total of 380 patients with ischemic stroke despite OAC will be included. Patients will be randomized 1:1 to the best medical treatment (control) or the combination of LAAO and DOAC or OAC. The study’s primary endpoint will be the occurrence of a cardioembolic event (ischemic stroke or arterial peripheral embolism) within the first 12 months after inclusion. |
HOSPITAL CLINIC OF BARCELONA | 2024-07-22 |
| 325 | Emergency Stroke Unit for Acute Cerebrovascular Events–A Prospective, Multicenter, Week-wise Randomized, Controlled Trial ( ESU-ACE-D ) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the prognosis of patients with hyperacute ischemic stroke (between 4.5-6 hours after the onset of symptoms) managed in a standard stroke unit adherent to guidelines versus managed in Emergency Stroke Unit (a new stroke unit based on low-field magnetic resonance imaging). |
YONGJUN WANG; | 2024-07-20 |
| 326 | Investigating The Effectiveness of Action Observation Therapy Applied in Addition to Conventional Treatment in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn the effectiveness of action observation therapy in patients with stroke. The main questions it aims to answer are: Is action observation therapy an effective method in stroke patients? Researchers will compare the results of two action observation-based exercises with conventional exercise to see whether action observation therapy works in the rehabilitation of stroke patients. Participants: Participants in one group will do action observation-based exercise for 24 sessions, while participants in the other group will do conventional exercise. |
OSMAN KARACA; | 2024-07-16 |
| 327 | Understanding The Need and Feasibility of Transitional Care Training Program Among Family Caregivers of Geriatric Stroke Survivors in Pakistan PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main intention of the study is to understand the need and feasibility of transitional care training program among family caregivers of geriatric stroke survivors in Pakistan |
NAJMA NAZ; | 2024-07-15 |
| 328 | Combined Effects Of Sensory Integration And Vestibular Exercises On Dizziness, Fall Risk And Quality Of Life In Post-Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine the combined effects of sensory integration and vestibular exercise on dizziness, fall risk and quality of life. |
ARUBA SAEED; | 2024-07-10 |
| 329 | A Prospective, Multicenter, Open-label, Randomized Controlled Trial of 3-month Versus 6-month Dual Antiplatelet Therapy After Implantation of NOVA Intracranial Sirolimus-eluting Stent System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective, multicenter, open-label, randomized controlled clinical trial, aims to assess the clinical non-inferiority of 3 months (short-term) vs 6 months (long-term) of Dual Anti-Platelet Therapy (DAPT) in patients after implanted NOVA intracranial sirolimus-eluting stent system. All participants met the inclusion criteria will be 1:1 randomized to 3 months or 12 months of DAPT at index procedure. |
LIANBO GAO; | 2024-07-09 |
| 330 | Adapted Cognitive Stimulation Therapy (CST) for Pre-frail Stroke Survivors: A Non-randomised, Acceptability and Feasibility Pilot Study Related Papers Related Patents Related Grants Related Experts View Highlight: Frailty is described as a type of vulnerability where one can struggle to recover fully from things that can put stress on one's body, e.g., cold weather or bronchitis. This can lead to negative health outcomes and is linked with early death, particularly if the person has had a stroke. Frailty was first operationalised by Fried et al. (2001) as the presence of at least three out of the following five clinical indicators: unintentional weight loss, exhaustion, weakness, slow walking speed and low level of physical activity. They also defined ‘intermediate frailty status', now referred to as 'pre-frailty’, … |
UNIVERSITY OF EAST ANGLIA | 2024-07-09 |
| 331 | Effectiveness of Intensive Training in Upper Limb Rehabilitation After Stroke: An Occupational Therapy Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to analyse the effect of intensive training on upper limb function in stroke patients. 16 stroke patients were randomly divided into two groups: the intensive group and the control group. The control group will be trained with robotic exoskeleton for upper limbs and task specific training, 3 sessions per week for 4 weeks, for 1 hour per day. The intensive group will do robotic exoskeleton for upper limbs and task specific training, 5 sessions a week for 4 weeks, for 2 hours a day. |
ENRIQUE VILLA BERGES; | 2024-07-05 |
| 332 | Safety and Efficacy of Selective Intra-Arterial Cooling Infusion Combined With Endovascular Thrombectomy in Acute Ischemic Stroke: A Multicenter, Randomized Controlled, Subject- and Assessor-Blind Clinical Trials PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, controlled, subject- and assessor-blinded clinical trial. The research objective is to evaluate the safety and efficacy of selective intra-arterial cooling infusion combined with endovascular therapy in the treatment of acute anterior circulation large vessel occlusion stroke. This trial aims to enroll 258 subjects. Patients assigned to the control group will receive best medical management (BMM) and endovascular therapy (EVT). Those in the selective intra-arterial cooling infusion group (IA-SCI group) will undergo selective intra-arterial cold saline infusion, in addition to BMM and EVT. Subjects will be interviewed face-to-face at randomization, 24±6 hours, 48±6 hours after randomization, … |
SHEN LI; | 2024-07-03 |
| 333 | Closed – Loop Neuromodulation of Post – Stroke Motor Dysfunction By Transcranial Magnetic Stimulation Synchronized with Specific Motor Task Training PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke. It will also learn about the safety of individualized online rTMS intervention methods. The main questions it aims to answer are: Does rTMS synchronized with motor training improve motor rehabilitation in patients with the ability to induce motor evoked potentials(MEPs)？ Dose individualized rTMS synchronized with motor training improve motor rehabilitation in patients without the ability to induce MEPs? Researchers will compare online rTMS to offline and sham stimulation in patients with MEPs to see if online rTMS works to alleviate motor dysfunction in preliminary trials. And compare individualized online rTMS to non-individualized online rTMS and sham in patients without MEPs to see if individualized online rTMS works to alleviate motor dysfunction in Randomized, double-blinded, and controlled trials. Participants will: randomized to one group acoording to the MEP condition of each person; receive rTMS treatment for 10 days, with 5 working days per week for a total of two weeks; receive magnetic resonance imaging (MRI) and electroencephalogram (EEG) evaluations before and after the entire treatment; conduct scales and MEP assessment one day before the treatment, as well as one day, one month, and three months after the treatment. |
XIAONAN HUANG; | 2024-07-02 |
| 334 | Predicting Outcomes of Breast-Conserving Surgery in Breast Cancer Patients Using The Modified 5-Item Frailty Index PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Breast cancer is the most common malignancy among women worldwide, with breast-conserving surgery (BCS) being a key treatment. The modified 5-item frailty index (mFI-5), a well-validated tool for assessing frailty, has shown predictive utility in other surgical contexts but remains under-explored in BCS. Methods: Using the American College of Surgeons National Surgical Quality Improvement Program database (2008-2021), the investigators identified adult female breast cancer patients who underwent BCS. Frailty was assessed using the mFI-5, scored from 0 to 5, … |
TECHNICAL UNIVERSITY OF MUNICH | 2024-07-01 |
| 335 | Impact of SGLT2-inhibitors on Post Contrast Acute Kidney Injury in Acute Coronary Syndrome Patients Receiving Invasive Strategy PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Percutaneous coronary intervention (PCI) is one of the most common invasive strategies employed in the diagnosis and treatment of coronary artery disease (CAD) patients. Invasive procedures necessitate the use of iodine-based contrast agents, which could lead to post contrast acute kidney injury (PC-AKI). Sodium-glucose cotransporter 2 (SGLT-2) inhibitors, as a class of oral antidiabetic medications, function by inhibiting SGLT-2, preventing the reabsorption of filtered glucose by the kidneys and thereby increasing glucose excretion in urine. In recent years, a series of studies including EMPA-REG OUTCOME, CREDENCE, DAPA-CKD, DECLARE-TIMI 58, … |
HAN YALING; | 2024-07-01 |
| 336 | Experimental Evaluation of The Virtual Eggs Test on Stroke Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study protocol focuses on evaluating the Virtual Eggs Test (VET) as a tool for assessing hand dexterity and grip strength control in post-stroke patients. The study aims to validate the reliability and concurrent validity of the VET, comparing its outcomes with established tests like the Nine Hole Peg Test (NHPT), the Motricity Index, the Semmes-Weinstein Monofilament Test (SWMT), and the Abilhand-ULA questionnaire |
FRANCESCA CECCHI; | 2024-07-01 |
| 337 | Comparison of Multi-session Anodal Cerebellar Transcranial Direct Current Stimulation Vs Anodal Cerebral Transcranial Direct Current Stimulation on Balance, Its Components and Postural Stability in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate which one of the two cerebellar and cerebral stimulation in comparison to sham stimulation is more effective in enhancing balance and postural stability in stroke patients |
QURAT UL AIN; | 2024-07-01 |
| 338 | Construction and Preliminary Application of COM-B Based Sedentary Behavioural Booster Intervention Programme for Elderly Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Explore the application effect of the sedentary behaviour intervention program for elderly stroke patients based on the COM-B model. |
LIU SHUXIAN; | 2024-07-01 |
| 339 | The Effects of Robot-Assisted Gait Training Concurrent With Self-Observation Training on Balance, Gait, Cognitive Function in Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effects of robot-assisted gait training Concurrent with self-observation training on balance, gait, and cognitive function in stroke participants. The main question it aims to answer is: Does robot-assisted gait training combined with self-observation improve balance abilities in stroke participants? Participants will be Group 1 Perform robot-assisted gait training combined with self-observation five times a week for four weeks. Group 2 Perform robot-assisted gait training five times a week for four weeks. All groups perform for 30 minutes per session. |
SAHMYOOK UNIVERSITY | 2024-07-01 |
| 340 | Longitudinal Multimodal Profiling of Balance and Gait In Stroke Using EEG and Lower Limb Sensors: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Balance and gait recovery is a critical aspect of post-stroke motor rehabilitation. Researchers have effectively utilized EEG to investigate different aspects of lower limb motor control, however there are several technical challenges in the existing brain computer interface (BCI) motor profiling. The study aims to test the EEG-BCI system to see if it’s effective in understanding the balance and walking patterns of post-stroke populations. |
WEE SENG KWEE; | 2024-07-01 |
| 341 | Effects of A Cognitive Gait Dual Task With Smartglasses on Walking Ability, Dual Task Interference, Cognition, and Falls in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to find out to determine changes in gait, dual-task interference, cognition, and fall scores during a cognitive walking dual task on a treadmill while wearing augmented reality-based smartglasses in stroke patients. Before the experiment, the investigators measure the subjects general characteristics, gait, cognition, dual-task interference, … |
SAHMYOOK UNIVERSITY | 2024-07-01 |
| 342 | Effect of Visual Feedback Balance Training System Combined with Repetitive Facilitative Exercise on Fall Risk After Stroke: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if visual feedback balance training system combined with repetitive facilitative exercise (RFE) work to treat stroke in adults. The main questions it aims to answer are: Does visual feedback balance training system combined with RFE reduce the fall risk of participants? Can the combination of intelligent rehabilitation robot training system and RFE achieve better effects? Researchers will compare 3 groups (RFE, visual feedback balance training system under RFE, … |
JINGZHI ZHANG; | 2024-07-01 |
| 343 | Effects of Transcranial Direct Current Stimulation on Lower Limb Performance in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Lower limb rehabilitation is especially important, as the simple act of regaining the ability to walk has subsequent effects on the ability to engage in activities of daily living .So, this study will contribute in describing the management of lower limb motor recovery along with the therapeutic intervention (MRP) with tDCS (anodal stimulation). This study aims to address some of the drawbacks observed in previous studies like allocation concealment, small sample size due to drop outs, short term effects of tDCS and experimental designs as well. |
MIRZA OBAID BAIG; | 2024-07-01 |
| 344 | Comparison Between The Efficacy of CIMT and NDT Along With Conventional Physiotherapy Treatment on Upper Extremity Rehabilitation Among Patients of Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the efficacy of CIMT and NDT among stroke patients To study the phenomena of transfer of training To study relationship between the MMSE score and stroke rehabilitation |
AYESHA FATIMA; | 2024-06-28 |
| 345 | Studying The Mechanisms of Visual-motor Transformation to Find Neurophysiological Markers of Altered Functions of Cortical Motor Circuits in Patients with Neurological Disorders and Developing Technologies for Their Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to explore potential pathways for recovery and adaptation of the motor cortex by examining cerebral blood flow characteristics and hemodynamic markers analyzed by functional near-infrared spectroscopy (fNIRS) in patients with hemiparesis after stroke. Participants in the study performed a simple stimulus-response task several times with one healthy and one paralyzed limb at different stages of basic rehabilitation. A group of healthy, age-matched volunteers participated in the same experiment to verify the stroke-related changes. The researchers recorded fNIRS signals, muscle activity using electromyography, and heart activity using electrocardiography. |
SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY | 2024-06-26 |
| 346 | Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS. |
DAVID LIEBESKIND; | 2024-06-24 |
| 347 | Effects of Transcranial Direct Cranial Stimulation on Upper Limb Function and Quality of Life in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Research on the effects of Anodal transcranial Direct Current Stimulation (tDCS) on hand dexterity and quality of life in stroke patients is limited. While the highlighted article focuses on Parkinson’s disease, it underscores anodal tDCS potential to modulate brain activity and promote neural plasticity, suggesting potential relevance to stroke rehabilitation |
MIRZA OBAID BAIG; | 2024-06-24 |
| 348 | Comparative Effects of Constraint-Induced Movement Therapy With Bilateral Functional Task Training On Hand Function In Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Task-oriented training is an approach that will encourage active participation of the patient making treatment functional and task orientated in order to achieve the best possible recovery following injury. Neurorehabilitation studies have shown that Constrained induced movement therapy can increase both motor function and the use of the paretic arm and that these improvements parallel changes in the activation of the brain sensorimotor network. Bilateral Functional Task Training which promotes the use of the paretic limb simultaneously with the nonparetic limb. Many of our daily chores are bimanual and utilize concurrent use of both arms. |
MARYAM ZAHID; | 2024-06-20 |
| 349 | Additional Effects of Kinesio-Taping Along with Conservative Physical Therapy on Upper Limb Function, Range of Motion and Spasticity in The Patients with Subacute Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized control trial will be done on diagnosed stroke patients of subacute stage in Fauji Foundation Hospital Rawalpindi and leading edge physical therapy and rehabilitation clinic.The purpose of the study is to determine Additional Effects of Kinesio-Taping along with conservative Physical Therapy on upper limb function, Range of motion and Spasticity in the patients with Subacute Stroke. The conservational physical therapy includes Passive and active ROMs 25 repetitions each, … |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-06-20 |
| 350 | Effects of Motor Relearning Program Versus Proprioceptive Neuromuscular Facilitation on Balance and Gait in Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized control trial will be done on diagnosed stroke patients of chronic stage in DHQ Hospital Mirpur and FF Hospital Rawalpindi physical therapy Department.The purpose of the study is to determine Effects of Motor Relearning Program Versus Proprioceptive Neuromuscular Facilitation on Balance and Gait in Stroke . Subjects will complete Berg Balance Scale (BBS). 10-meter walk test for gait speed will be used for measuring walking speed in meters per second over a short distance, Timed-Up-And-Go (TUG) Test will be used for test of functional mobility and gait parameter. All these measures will be taken at baseline, … |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-06-20 |
| 351 | Molecular Characteristics of Phlegm-heat Syndrome in Ischemic Stroke: A Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The molecular characteristics of ischemic stroke with phlegm-heat syndrome and candidate biomarkers were identified based on multi-omics data. The main purpose of this study is to validate the molecular characteristics and biomarkers of phlegm-heat syndrome in ischemic stroke, and to demonstrate the association of biomarkers with clinical outcomes. |
YING GAO; | 2024-06-20 |
| 352 | Additional Effects of Functional Muscle Training With Turning Based Specific Training During Turning in Post Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is the leading cause of disability leading to Gait and balance dysfunction leading to decreased Quality of Life. Difficulty in turning is a major target in Gait Rehabilitation. Task specific exercises has proven to be effective in all stages of stroke rehabilitation, therefore Turning based specific training is to be used in order to improve turning and balance in post stroke patients moreover functional strength training of lower extremities prove to be more effective than traditional training. |
FOUNDATION UNIVERSITY ISLAMABAD | 2024-06-20 |
| 353 | Effectiveness of Intelligent Rehabilitation Robot Training System Combined With Repetitive Facilitative Exercise on Upper Limb Motor Function After Stroke: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if intelligent rehabilitation robot training system combined with repetitive facilitative exercise (RFE) work to treat stroke in adults. The main questions it aims to answer are: Does drug intelligent rehabilitation robot training system combined with RFE improve the upper limb motor function of participants? Can the combination of intelligent rehabilitation robot training system and RFE achieve better effects? Researchers will compare 3 groups (RFE, intelligent rehabilitation robot training system under RFE, … |
JINGZHI ZHANG; | 2024-06-15 |
| 354 | The Effect of Functional Inspiratory Muscle Training Versus Inspiratory Muscle Training on Trunk Control and Respiratory Functions in Patients With Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare the effectiveness of functional inspiratory muscle training (IMT) versus inspiratory muscle training on trunk control, respiratory parameters, activity, and participation in chronic stroke patients. The study is a prospective, randomized, and parallel study. Forty-four stroke patients who meet the inclusion and exclusion criteria will be included in the study. The patients to be included in the study will be divided into equal numbers into two groups, F-IMT Group, and IMT Group, by block randomization method. Participants’ trunk control will be measured with the Trunk Disability Scale and Trunk Control Test, … |
YUNUS EMRE TUTUNEKEN; | 2024-06-15 |
| 355 | Transcutaneous Spinal Cord Stimulation to Facilitate Recovery of Upper Extremity Function in Individuals With Stroke or Spinal Cord Injury – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI). More recently, the use of invasive, epidural electrical stimulation of the spinal cord has also demonstrated promise in restoring upper extremity function post-stroke. However, the effect of stimulation parameters such as electrode configuration and stimulation frequency on excitability of the nervous system remains unknown preventing the opportunity to fully exploit this noninvasive stimulation paradigm. Additionally, the utility of noninvasive tcES in the stroke population remains unexplored. This project utilizes a comprehensive set of neurophysiological techniques, … |
JESSICA D’AMICO; | 2024-06-15 |
| 356 | Portable Neuromodulation Stimulator (PoNS®) Therapy for Gait and Balance Deficits in Chronic Stroke Survivors: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Double blind, randomized, placebo controlled, interventional clinical trial investigating the efficacy and safety of PoNS therapy on improving dynamic gait and balance deficits in chronic stroke survivors. |
HELIUS MEDICAL | 2024-06-12 |
| 357 | Outcome Measures of Modified Constraint Induced Movement Therapy Versus Dual Task Training on Upper Extremity and Cognitive Functions in Patients With Hemiparesis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: All stroke patients were assessed via isokinetic dynamometer, Montreal cognitive assessment scale (MOCA) and Fugl Myer Upper extremity (FMUE) before and after the treatment program. |
AHMED ALSHIMY; | 2024-06-10 |
| 358 | Identifying The Role of Flow Mediated Dilatation Assessment in Acute Coronary Syndromes – Evaluation of The Cor-IS Technology (the FLARE-ACS Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, single-center, observational study aiming to assess the predictive role of flow mediated dilatation in acute coronary syndromes, combined with echocardiographic and biochemical indices. The novel Cor-IS technology will also be evaluated. |
CHRISTODOULOS E. PAPADOPOULOS; | 2024-06-01 |
| 359 | Clinical Features and Prognostic Markers in Adult Patients With AE Requiring ICU Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Autoimmune encephalitis (AE) is a potentially life-threatening inflammation of the central nervous system (CNS) and constitutes 20%-30% of encephalitis cases in adults AE often leads to subacute, severe, and debilitating encephalitis necessitating long-term management in a neurologic intensive care unit (ICU). This study aims to explore the predictive factors for poor clinical outcomes by analyzing the clinical characteristics and prognosis of adult patients with critical AE requiring ICU admission. Prospective observational single center study in neurologic ICU, the second Xiangya hospital, … |
LIXIA QIN; | 2024-06-01 |
| 360 | Trial of Rescue Endovascular Treatment for Progressive Acute Mild Ischemic Stroke With Basilar Artery Occlusion With Extended Time Window PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, multicenter, open-label, blinded-endpoint, randomized controlled trial to evaluate whether best medical management (BMM) combined with endovascular therapy (EVT) improves neurological outcomes compared to BMM alone in patients with progressive acute mild ischemic stroke due to basilar artery occlusion within an extended time window. |
FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE | 2024-06-01 |
| 361 | Investigation of Individuals with Stroke Admitted to Occupational Therapy Unit Within The ICF Framework: One Month Follow-up Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study examined stroke patients who applied to occupational therapy units within the framework of ICF, following the rehabilitation process, and defining frequently used measurements in terms of ICF codes |
LEYLA KAYA OZTURK; | 2024-06-01 |
| 362 | Repeated Transcranial Magnetic Stimulation (rTMS) Promotes Neural Function Recovery in Patients With Ischemic Stroke By Affecting Local Cerebral Blood Flow and Brain Network PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if transcranial magnetic stimulation(rTMS) can improve neurological rehabilitation in patients with acute ischemic stroke. The main questions it aims to answer are: Can rTMS Promote Recovery of Limb Impairment in Patients with Acute Ischemia? Can rTMS Cause Changes in the Functional Connections of Brain Networks in Patients? Researchers will compare rTMS therapy to non-stimulation therapy to see if rTMS is effective in promoting neurological recovery from ischemic stroke. Participants will: Receive rTMS or sham stimulation with LF-rTMS on the contralateral M1 of the brain lesion for 20 minutes, 1200 pulses, … |
THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY | 2024-06-01 |
| 363 | Outpatient Stroke Rehabilitation Supported By Nature Interventions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Outpatient participants with a recent stroke diagnoses receive complimentary rehabilitation. The nature interventions include ergo- and physiotherapeutic and neurocognitive tasks with the support of an psychotherapeutic frame designed to be performed in a nature environment. |
HANNA HAVERI; | 2024-06-01 |
| 364 | An Exploratory Study of A Wearable Robotic Hand Orthosis in The Chronic Stroke Population in Singapore: A Clinic to Home Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Upper limb deficits usually remain in 75% of the stroke survivors despite completing full rehabilitation. This is due to lack of effectiveness of rehabilitation and the degree of support and resources available. In this study, the investigators plan to study the use of assistive technologies in chronic stroke survivors. |
TEGAN PLUNKETT; | 2024-06-01 |
| 365 | Variability of Healthy People and People After Stroke Results in The Nine Hole Peg Test PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Main aim of the study is to find out how many attempts of each subtest in the Nine Hole Peg Test should be done in clinical practice during testing people after stroke who are 20-64 years old. |
KATEŘINA RYBÁŘOVÁ; | 2024-06-01 |
| 366 | Study on The Safety and Efficacy of The Trans-Carotid Artery Occlusion Shunt System Combined With Introducer Sets for Cerebral Protection During Carotid Angioplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to evaluate the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets for Cerebral Protection During Carotid Angioplasty |
ZHONG CHEN; | 2024-06-01 |
| 367 | Telerehabilitation After A Stroke: Feasibility, Safety and Performance Evaluation of An Application Based Training Programme for Patients After A Stroke in The Subacute Phase PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this investigation is to evaluate the feasibility, safety and performance of an application-based training programme in patients after a stroke in the subacute phase. – Is the training programme ‘TeleRehaStroke’ using the mobile application ‘Blended Clinic’ for patients after a stroke feasible and usable? – How is the user experience of the mobile application-based training programme? Participants will: – Get to know the programme and use the application ‘Blended Clinic’ during their last weeks before discharge from the inpatient rehabilitation. – Be guided through inpatient setting, … |
CORINA SCHUSTER-AMFT; | 2024-06-01 |
| 368 | Effects of Appropriate Technology for Home-based Rehabilitation in Patients With Post-stroke Physical Dysfunction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the effect of S-HRAT to improve patients’ motor function and activities of daily living. |
XI CHEN; | 2024-06-01 |
| 369 | Effects of Cognitive Motor Dual Task Versus Task Specific Training on Cognition and Motor Functioning in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study focuses on Dual Task Training as daily living involves many dual task conditions, in which a person requires to do two or more tasks at same time. without the ability to carry out these types of Dual movements. This study aims to improve the ability to do two tasks at same time, targeted to decrease the risk of fall in stroke patients. This study helps in understanding how multiple tasks simultaneously affects patients’ abilities and creating effectiveness programs. |
BUSHRA SULTANA; | 2024-05-30 |
| 370 | Effects of End-Effector Type Rehabilitation Robots-Morning Walk on Symmetrical Walking Patterns in Individuals With Hemiparesis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, our objective is to explore and evaluate interventions to improve the process of recovery following a stroke. The main focus is on enhancing symmetrical walking patterns in adults who have experienced neurological deficits due to a stroke. The primary tool will be an end-effector type rehabilitation robot, the Morning Walk®. This robot has been specifically designed to assist in enhancing symmetrical walking patterns for individuals recovering from a stroke Morning Walk® has received approval from the FDA, meaning it meets stringent safety and efficacy standards. |
THE UNIVERSITY OF TEXAS MEDICAL BRANCH GALVESTON | 2024-05-30 |
| 371 | To Determine The Effects of The Otago Exercise Program on The Frequency of Falls, Balance Capabilities, and Overall Physical Performance in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine the effects of the Otago Exercise Program (OEP) on falls and balance as well as overall physical performance. Participants will be divided into two groups; control and intervention group. It is a week-long study, the participants will be assessed through the Berg Balance Scale (BBS), Time Up and Go (TUG) and Fugl-Meyer Assessment (FMA). |
IMRAN AMJAD; | 2024-05-23 |
| 372 | Determining The Minimal Clinically Important Difference (MCID) for The TOPICS-SF and PROMIS-10 in Older Patients That Suffered An Ischemic Stroke or Transient Ischemic Attack (TIA), Using An Anchor-based Approach PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patient-related outcome measures (PROMs) play a crucial role in assessing patient outcomes in healthcare. Two of these PROMs are the TOPICS-Short Form (TOPICS-SF) and PROMIS Global Health-10 (PROMIS-10). We aim to determine the MCID for the TOPICS-SF and PROMIS-10 in older people that suffered an ischemic stroke or Transient Ischemic Attack (TIA), using an anchor-based method, to determine the clinical significance of differences in patients’ scores. |
NATHALIE VAN DER VELDE; | 2024-05-20 |
| 373 | EFFECTS OF THERA-TRAINER BASED EXERCISES ON MOTOR AND COGNITIVE PERFORMANCE AMONG HEMİPARATİC STROKE PATIENTS. A RANDOMİSED CONTROL TRİAL PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Technology-supported training supports the rehabilitation process by providing high-intensity, repetitive, and task-specific treatment, contributes to the recovery process, and facilitates the restoration of arm function (Bertani et al., 2017). Technology-supported rehabilitation studies for the upper extremity are performed using different devices. THERA-Trainer Tigo is used for the mobilization of individuals with limited mobility after trauma or due to any reason; it is suitable for passive movement training and active movement. Treatment with active-passive exercise devices facilitates rehabilitation with natural and rhythmic movements. It allows almost all patients, from wheelchair users to walkers, … |
FATMA KÜBRA ÇEKOK; | 2024-05-19 |
| 374 | Effects of Bilateral Upper Limb Robot-assisted Rehabilitation on Motor Recovery in Patients With Subacute Stroke: An Italian Multicenter Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to study the clinical effects of a robotic rehabilitation treatment through a bilateral exoskeleton (Bilateral Robot-Assisted Therapy-BRAT) during standard rehabilitation, on motor recovery, compared to conventional arm re-education in people suffering from stroke in the subacute phase. The main question it aims to answer is what the effectiveness of Bilateral Robot-Assisted Therapy (BRAT) is in rehabilitating the upper limb in individuals with subacute stroke compared to conventional rehabilitation treatment in terms of motor function improvement as measured by the Fugl-Meyer Assessment – Upper Limb (FMA-UL), … |
SANAZ POURNAJAF; | 2024-05-19 |
| 375 | Effect of Trans-auricular Vagus Nerve Stimulation on Plasticity Biomarkers,Interleukin-6 and Motor Performance Post Stroke : A Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Seventy-eight clinically verified Egyptian patients from both sexes with ischemic stroke that occurred at least 6 months to 2 years before inclusion will be randomly assigned into 2 groups, control group (GA) and the experimental group (GB). Patients will be randomly assigned into two equal groups: the control group (GA) and the experimental group (GB). Patients in the control group (GA) will be treated with sham Vagus nerve stimulation (taVNS) immediately before a selected physical therapy program, while in the experimental group (GB), … |
ENGY BADRELDIN SALEH MOUSTAFA; | 2024-05-18 |
| 376 | Effect of Speech Rehabilitation Based on Mobile Application for People with Dysarthria After Stroke: A Single-Center, Investigator-Blinded, Randomized, Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the efficacy of smartphone-based speech therapy administered at home compared with usual care. Participants will be randomized into the treatment and waitlist control groups with an allocation ratio of 1:1. |
YUNJUNG KIM; | 2024-05-15 |
| 377 | Investigation of The Effect of Using Plantar Flexion Resistant Ankle-Foot Orthosis in Stroke Patients With Genurecurvatum Gait PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypothesis 1: Ho: Ankle-foot orthosis, which fixes the ankle at different angles (3 degrees dorsiflexion – 5 degrees dorsiflexion), has no effect on knee hyperextension control in stroke patients with genurecurvatum gait. H1: Ankle-foot orthosis, which fixes the ankle at different angles (3 degrees dorsiflexion – 5 degrees dorsiflexion), has an effect on knee hyperextension control in stroke patients with genurecurvatum gait. Hypothesis 2: Ho: Ankle-foot orthosis, which fixes the ankle at different angles (3 degrees dorsiflexion – 5 degrees dorsiflexion), has no effect on pelvic movements in stroke patients with genurecurvatum gait. H1: Ankle-foot orthosis, … |
SULEYMAN KORKUSUZ; | 2024-05-15 |
| 378 | Personalized Hemodynamic and Metabolic Signatures of Revascularization Response in Moyamoya Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD). MMD is a condition characterized by narrowing or obstruction of major arteries in the brain and people with MMD have a high risk of stroke. Study participants will be enrolled from Vanderbilt University Medical Center and Johns Hopkins Hospital and will undergo up to two MRI scans where measurements of cerebrovascular reserve are performed using inhaled room air mixed with 5% carbon dioxide. Scans will be performed before and after surgeries to treat MMD, all surgeries are clinically indicated and are not research procedures. To further understand how surgeries impact brain health, we will also perform neurological exams and cognitive testing at approximately the same time as the imaging scans. The overall goal is to incorporate advanced imaging and cognitive assessments to understand how surgeries improve brain health in these patients, and furthermore, to use this information to develop improved screening tools for stroke risk and decisions about surgery. |
MANUS DONAHUE; | 2024-05-13 |
| 379 | The EFFECT of PHYSIOTHERAPY on CORPUS CALLOSUM VOLUME in STROKE PATIENTS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study was aimed to determine the volumetric change in the corpus callosum after the rehabilitation program in patients with stroke. A total of 42 patients (22 males, 20 females), 21 right hemiplegic and 21 left hemiplegic patients with unilateral hemiplegia were enrolled in the rehabilitation program. Traditional physiotherapy treatment was applied 5 days in a week, 1 hour in a day for 6 weeks. The corpus callosum volumes were measured and evaluated on Magnetic Resonance Imaging (MRI) images before and after the treatment. |
SONGÜL BAĞLAN YENTÜR; | 2024-05-10 |
| 380 | The Effect of Robotic Rehabilitation and Vagus Nerve Stimulation in Addition to Robotic Rehabilitation on The Patient’s Functional Level and Autonomic Nervous System in Patients With Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was conducted in patients with ischemic stroke; This study was conducted to examine the effect of robotic rehabilitation and transcutaneous auricular vagal nerve stimulation applied in addition to robotic rehabilitation on the patient’s functional level and autonomic nervous system. 40 people over the age of 18 participated in the study. They were randomly divided into two groups: robotic rehabilitation and transcutaneous auricular vagal nerve stimulation applied in addition to robotic rehabilitation. While the robotic rehabilitation group received Lokomat and neurological rehabilitation, the other group received stimulation with the Vagustim device, which is applied non-invasively through the ear, … |
SEFA HAKTAN HATIK; | 2024-05-10 |
| 381 | Effects of Mulligan-Based Lumbar Mobilization on Trunk Position Sense, Balance, and Gait in Stroke Survivors: A Randomized Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a pathology caused by disturbances in the brain’s arterial circulation, leading to high morbidity rates. Individuals who experience a stroke often face neurological impairments such as motor, sensory, and cognitive dysfunctions, which negatively impact muscle strength, postural control, sensation, and gait, reducing their independence in daily activities. Balance deficits in stroke patients increase the risk of falls and contribute to a fear of falling. Improving balance control is a key goal in rehabilitation. The importance of the trunk in balance control and rehabilitation is well-established, … |
MUSTAFA ERTUĞRUL YAŞA; | 2024-05-08 |
| 382 | Investigation of The Effect of Upper Extremity Robot-Assisted Therapy on Upper Extremity Performance in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Upper extremity hemiparesis is one of the most common symptoms after stroke. Robot-assisted therapies have been used as an approach to rehabilitation of upper extremity hemiplegia in recent years. Robot-assisted therapy is an approach to post-stroke rehabilitation that uses robotic devices to provide motor or task-oriented training to patients. When the literature is examined, there are studies showing that robot-assisted therapies are similar or superior to conventional methods. In order to provide the most effective rehabilitation approach in upper extremity robots, … |
IZEL DEMIRHAN; | 2024-05-06 |
| 383 | Effect of Planter Vibration and Otago Exercise on Risk of Fall and Quality of Life in Hemiplegic Elderly PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine effect of Plantar vibration and Otago exercise on risk of fall and quality of life in hemiplegic elderly |
SANDRA AZIZ GUIRGUIS; | 2024-05-05 |
| 384 | Comparison Between Incidence of Pneumonia in Non-ventilated Cerebrovascular Stroke Patients Suffering from Bulbar Palsy Depending on Nasogastric Tube Feeding and Those Who Are Totally Parenterally Fed PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One of the most serious complications in the critically ill patient complaining of bulbar palsy is aspiration pneumonia. These patients are scheduled for nasogastric tube feeding trying to avoid recurrent aspiration and subsequent aspiration pneumonia. Even though, the risk of aspiration is still present. Putting a total parenteral nutrition regimen for these patients is a supposed strategy to avoid aspiration pneumonia till recovery from bulbar palsy or planning for tracheostomy and or feeding gastrostomy. |
ADEL ELANSARY; | 2024-05-05 |
| 385 | Understanding The Relationship Between Controlling Risk Factors and Cerebral Haemodynamic Changes in Lacunar Stroke, and Its Interaction With Ageing PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke. Participants will be asked to undergo a simple brain blood flow assessment at their initial appointment, whereby they will be asked to sit and stand twice. The patients will then be asked for a follow-up assessment 4 weeks after, … |
UNIVERSITY OF LEICESTER | 2024-05-02 |
| 386 | Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic StrokE Despite Anticoagulation Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Atrial fibrillation (AF) is one of the most common cardiac arrhythmias and cardioembolic stroke due to AF is its major complication. Direct oral anticoagulants (DOAC) reduce the risk of cardioembolism in patients with AF. Despite DOAC therapy, there is a significant residual stroke risk of 1-2%/year. Recent data from the Swiss Stroke Registry found 38% of patients with AF and ischemic stroke were on prior anticoagulant therapy (approximately 400 patients per year in Switzerland). The investigators found in a prior observational study, … |
LORENZ RÄBER; | 2024-05-01 |
| 387 | Identifying Vertical Perception Loss in People With Acute Stroke: A Feasibility Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to establish if it is feasible to identify vertical perception deficits in people with acute stroke. The primary purpose to the study is: • To establish the feasibility of completing the Catherine Bergego Scale, Scale for Contraversive Pushing (SCP) and bucket test in a clinical environment with acute stroke patients to assist with identification of vertical perception loss. Participants will be asked to complete the assessments with a therapist 48 hours after admission. If they are not completed for any reason attempts will be made to complete them at one, … |
UNIVERSITY OF WINCHESTER | 2024-05-01 |
| 388 | Effects of Stabilizing Reversal and Rhythmic Stabilization Versus Pelvic Proprioceptive Neuromuscular Facilitation on Trunk Control, Postural Stability and Mobility in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effects of stabilizing reversal and rhythmic stabilization versus pelvic proprioceptive neuromuscular facilitation on trunk control, postural stability and mobility in stroke patients. The main question it aims to answer is: Is there any difference in effects of stabilizing reversal and rhythmic stabilization versus pelvic proprioceptive neuromuscular facilitation on trunk control, … |
WAJIHA SHAHID; | 2024-05-01 |
| 389 | Impact of Aerobic Training on Cardio-respiratory Fitness and Health Related Quality of Life in Stroke Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a major health problem among Egyptian population; an obvious raise in stroke prevalence in all Egyptian governorates. Most stroke survivors commonly develop disabilities those were correlated with restricted physical activity levels. Stroke survivors’ cardio-respiratory fitness has several negative impacts such as elevated risk of being affected by other cardiovascular diseases. So, the current study will be conducted to cover the lack in literature concerning the effect of aerobic training on cardiovascular endurance in stroke survivors aiming to faster recovery and reduce the risk of cardiac dysfunction and recurrent strokes. |
ADLY A ADAM; | 2024-05-01 |
| 390 | Portable Neuromodulation Stimulator (PoNS®) Therapy for Gait and Balance Deficits in Chronic Stroke Survivors: A Single-Arm Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Objective: To further evaluate the aspects of safety related to PoNS therapy in chronic stroke survivors. Secondary Objectives: To further evaluate the efficacy of PoNS on improving dynamic gait and balance, establishing durability of effect, risk of falling and fall rate. As well as adherence to PoNS device utilization. Exploratory Objectives: To further evaluate quality of life to measure physical, mental, behavioral, and general health, as well as functional decline (\> 30% on gait or balance improvement at endpoint) during the 12-week follow-up. |
HELIUS MEDICAL | 2024-05-01 |
| 391 | Effects of Robotic Assisted Therapy and Functional Electrical Stimulation on Upper Limb Motor Function in Subacute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is one of the leading causes of mortality worldwide and is the leading cause of disability. Currently, a large number of novel treatments are emerging with the aim of recovering the highest functionality and quality of life for these patients, including Robot Assisted Therapy (RAT) and functional electrostimulation (FES). The aim of this study is to observe the effect of FES with respect to conventional treatment and RAT for the improvement of motor function of the upper limb. For this purpose, a clinical trial will be carried out in which participants will be divided into two groups, … |
ALFREDO LERÍN CALVO; | 2024-05-01 |
| 392 | Effect of Transcranial Direct Current Stimulation Combined With Intermittent Oral to Esophageal Tube on Dysphagia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a double-blind randomized controlled trial, lasting for 15 days for each participant. Patients with post-stroke dysphagia who receive treatment at the Rehabilitation Department are selected as the study subjects. The patients are randomly assigned to either the experimental group or the placebo group. All patients receive routine rehabilitation therapy and swallowing rehabilitation training, along with enteral nutrition support using Intermittent Oro-esophageal Tube. In addition to these interventions, patients in the experimental group receive transcranial direct current stimulation, while the instruments used for patients in the placebo group only illuminate an indicator light without any actual effect. |
ZENG CHANGHAO; | 2024-05-01 |
| 393 | Community Health Worker Assisted Task Specific and Cognitive Therapy at Home With Exposure After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: CATCHES is a novel intervention for preliminary testing, integrating Task Specific Therapy at home guided by Community Health Workers (CHW) under supervision of a licensed Physical Therapist (PT) guided by telehealth based Cognitive Behavioral Therapy (CBT) to reduce task specific fears through repetitive exposure and adaptive behavioral activation strategies and facilitate engagement in physical activity. 1. To integrate and establish feasibility of CATCHES intervention. Hypothesis: A multidisciplinary team providing home based TST with exposure therapy tailored to an underserved urban setting will inform a patient-centered behavioral intervention to reduce fear of falling (FOF) among post-acute stroke patients returning home. Feasibility outcomes will include recruitment, retention, and fidelity of implementation. 2. Test effects of the intervention on hypothesized treatment mechanism of fear of falling. Hypothesis: Therapy will reduce task specific fear of falling Primary outcome will be change in Activities-specific Balance Confidence Scale. 3. Explore physical activity measures subjectively and objectively. Exploratory outcomes include pre and post Timed Up and Go test, patient reported outcome surveys and activity as measured by wearable devices. |
IMAMA A. NAQVI; | 2024-05-01 |
| 394 | Effect of Task Oriented Training on Cognitive Function in Elderly Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The impact of stroke at the time of diagnosis is on the attention and executive functions, which may be impaired at various post-stroke intervals. Objective: To improve Cognitive Function in Elderly Stroke Patients through Task Oriented Training. Subjects and methods: Forty Elderly stroke patients from both sexes assigned randomly into two equal groups. In Group A were allocated to task oriented training in addition to traditional physical therapy program, group B received traditional physical therapy program, three sessions/week for 3 months. Cognitive Function assessed by Reha-com device, Addenbrooke’s Cognitive Examination Revised (ACE-R) test and Montreal Cognitive Assessment Scale (MoCA), … |
AHMED METWALLY MOHAMED ELSHINNAWY; | 2024-05-01 |
| 395 | The Effect of Physiotherapy Rehabilitation Program on Spasticity Level, Upper Extremity Functions, Activities of Daily Living, and Kinesiophobia in Hemiplegic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigated the effects of rehabilitation exercises on spasticity levels, upper extremity functions, activities of daily living, and kinesiophobia in patients with hemiplegia following a stroke. |
YASEMIN ŞAHBAZ; | 2024-05-01 |
| 396 | Effects of Graded Repetitive Arm Supplementary Program Versus Task Based Training on Upper Limb Function in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine effects of graded repetitive arm supplementary program versus Task based training on Upper limb function in stroke patients. |
ZEEST Z HASHMI; | 2024-05-01 |
| 397 | Effects of Motor Relearning Program With and Without Electrical Muscle Stimulation on Gait, Functional Independence and Quality of Life in Hemiplegic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effects of motor relearning programme with and without electrical muscle stimulation on gait, functional independence and quality of life in hemiplegic stroke patients. |
ARUBA SAEED; | 2024-05-01 |
| 398 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate The Effect of Retatrutide on The Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 Kg/m2 and Atherosclerotic Cardiovascular Disease And/or Chronic Kidney Disease PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor. |
PHILLIP MADONIA; | 2024-04-30 |
| 399 | THE EFFECT OF VIRTUAL REALITY APPLICATIONS ON SITTING BALANCE IN HEMIPLEGIA: A RANDOMIZED CONTROLLED STUDY PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: The aim of this study was to investigate the effects of virtual reality application on quality of life and functionality, especially sitting balance, in hemiplegic patients. |
EBRU YILMAZ YALCINKAYA; | 2024-04-29 |
| 400 | Personalised Health Cognitive Assistance for RehAbilitation SystEm (PHRASE): A Feasibility Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The incidence of cognitive and neuromotor impairment caused by strokes has become a growing challenge. The patient’s journey to recovery in the healthcare system involves multiple phases, spanning from initial hospitalization to in-patient and out-patient rehabilitation, finally leading to the patient’s return to home. The access to stroke units and rehabilitation varies within Europe. Unfortunately, not everyone has access to rehabilitation programs, and the benefits derived from these programs often decline after hospital discharge. Currently, the support of the patient is organized in a rather fragmented way, … |
PAUL VERSCHURE; | 2024-04-25 |
| 401 | Transcutaneous Vagus Nerve Stimulation for Language Recovery After Stroke: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aphasia is an acquired language disorder. Stroke is the most common cause of aphasia, which affects 30% of stroke survivors. Speech and Language Therapy (SLT) can help people with aphasia but it may not be provided at the required intensity. Access to therapy is often limited after the first few months following stroke. People with aphasia can improve with therapy many years after stroke but these benefits have not been found to translate to day to day conversation. Transcutaneous Vagus Nerve Stimulation (tVNS) is a non-invasive technique which involves stimulating a branch of the vagus nerve through the skin of the ear, using a small earpiece. This technique is safe and has been approved for use in headache. There is promising evidence that tVNS can improve motor rehabilitation in chronic stroke. This technique may be helpful in aiding language recovery in individuals with chronic aphasia. The current pilot study will primarily assess the feasibility, safety and tolerability of self-directed tVNS paired with computer-based SLT, in individuals with chronic stroke-related aphasia. Secondly, the study aims to explore the effect of the intervention on word-finding ability and to explore potential mechanisms of action. Participants will be randomly allocated to an active or sham tVNS group. Participants will be asked to use the stimulation device at home for 6 weeks, whilst completing computer-based SLT. To date, there are no published studies exploring the use of tVNS in aphasia. An indication of study feasibility may support the development of a larger RCT to explore treatment efficacy. |
ALI ALI; | 2024-04-25 |
| 402 | A Post-Market Clinical Follow-up Study to Evaluate The Long-Term Safety and Effectiveness of Surpass Evolve Flow Diverter System PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, multi-center, single-arm, open-label, observational, post-market clinical follow-up. The expected duration of the study is 8 years (including up to 5-years’ follow-up). Each subject will be followed up per standard of care (SoC) at each study site. |
STRYKER NEUROVASCULAR | 2024-04-24 |
| 403 | Efficacy and Safety of The Ton-bridge Carotid Stent for The Treatment of Carotid Artery Stenosis: A Prospective, Multicenter, Non-inferiority, Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to evaluate effectiveness and safety of the Ton-bridge carotid stent for the treatment of carotid artery stenosis. |
LIQUN JIAO; | 2024-04-24 |
| 404 | Erfassung Kardialer Funktionsparameter in MRT Und Echokardiographie Bei Patienten Mit Ethyltoxischer Leberzirrhose Und Transjugulärer Intrahepatischer Portosystemischer Shunt (TIPSS)-Anlage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (TIPSS) implantation in order to draw conclusions for future treatment methods or exclusion criteria prior to TIPS implantation. The main questions to be answered are: How often do symptoms of cardiac decompensation develop over a one year period? What laboratory, clinical or imaging morphological changes are associated with this? In addition to the standardised clinical procedure for TIPSS implantation, participants will undergo 3 cardiac magnetic resonance imaging (MRI), extended echocardiographic examinations (both just before, … |
STEPHANIE GRÄGER; | 2024-04-19 |
| 405 | Comparison of Activity Intensity, Performance, and User’s Experience Between Custom and Non-custom Serious Games Combined With Balance Boards for Persons After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Serious games for rehabilitation are delivered through systems that are either customised or non-customised. Custom serious games allow for control of feedback, setting of game speed and difficulty, while non-custom games are less adaptable but provide attractive graphics and sounds. The study compared the activity intensity and user experience of persons after stroke while playing custom and non-custom virtual reality balance games that were both game- and self-paced. |
URŠKA PUH; | 2024-04-19 |
| 406 | Combined Effects of Restorative and Compensatory Rehabilitation Techniques on Executive Functions in Stroke With Mild Cognitive Impairment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke. |
AROOSA TARIQ; | 2024-04-16 |
| 407 | The Effect of Spasticity Severity on Peripheral Muscle Oxygenation in Hemiparetic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Conditions such as hemiparesis, sensory and motor impairment, perceptual impairment, cognitive impairment, aphasia, and dysphagia may be observed after stroke. Motor impairment after stroke may occur due to damage to any part of the brain related to motor control. There is much clinical evidence that damage to different parts of the sensorimotor cortex in humans affects other aspects of motor function. Loss of strength, spasticity, limb apraxia, loss of voluntary movements, Babinski sign, … |
SELCAN SUICMEZ; | 2024-04-15 |
| 408 | Post-stroke Haptic Feedback Use Deficit: A Comparative and Reliability Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this comparative and reliability study is to highlight a deficit in the use of vibrotactile sensory feedback (haptic effect) in the planning and execution of fine manual dexterity movements after stroke. The investigators will include 3 groups of subjects, 1 group of young healthy subjects, 1 of older subjects matched in age and sex to the group of chronic stroke patients. Participants will take part in clinical tests of fine motor skills and sensitivity and will use a device to assess the key components of manual dexterity, … |
GUILLAUME TURC; | 2024-04-15 |
| 409 | Effect of Superficial Neuromuscular Stimulation on Ultrasonographic Findings of Oropharyngeal Swallowing in Post-stroke Dysphagic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Swallowing disorder in stroke patients is a significant cause of morbidity and mortality as it can cause aspiration pneumonia. Electrical stimulation has proven to be effective in post-stroke dysphagic patients.10 patients who have symptoms of post-stroke dysphagia, meet the inclusion criteria and volunteer to participate will be included in the study. Included patients will be randomized into 2 groups. The exercise program will be applied to both groups as a home program for 4 weeks. |
HAVVA TALAY ÇALIŞ; | 2024-04-15 |
| 410 | Investigation of Incidence Rate of Post-stroke Seizure and Post-stroke Epilepsy in Patients Under Treatment With Alteplase and Correlated Factors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This retrospective cohort study was conducted by reviewing the records of consecutive patients referred to Bu Ali Sina Hospital from 2016 to 2023, who were hospitalized with a diagnosis of ischemic stroke. The records of all patients treated with intravenous alteplase during the above period were extracted, and the relevant characteristics were recorded in a questionnaire. In each year, patients with ischemic stroke who were not treated with alteplase but were hospitalized at the Bu Ali Center were selected in a similar number to patients who received alteplase in the same year, … |
NASIM TABRIZI; | 2024-04-14 |
| 411 | Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke and Its Mechanism of Brain Electricity and Brain Metabolism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pentoxifylline can improve cognitive impairment after ischemic stroke, possibly by improving the level of cerebral blood flow, affecting the content of blood oxygen and metabolic substances in the brain, and then playing a protective role in the transmission of nerve electrical signals, and ultimately improving cognitive function. The patients with cognitive impairment and non-dementia PSCIND after ischemic stroke were randomly divided into two groups. In addition to the basic drugs of ischemic stroke, … |
BING HAN; | 2024-04-10 |
| 412 | Evaluating Validity and Reliability of A Novel In-house Developed, Robot-based Sensorimotor Processing Assessment Paradigm for The Upper Limb in The Chronic Phase After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sensorimotor function of the upper limb is often impaired after stroke, even in the chronic phase (minimum 6 months after stroke). Currently, an optimal assessment for sensory processing, one of the most important sensory functions, does not exists. However, our research team has developed a novel assessment paradigm using the KINARM End-Point robot to assess the level of sensory processing of the upper limb. Within a previous study, … |
GEERT VERHEYDEN; | 2024-04-10 |
| 413 | Telerehabilitation to Improve Balance and Mobility in Patients After Stroke: Group Physiotherapy Performed in Individuals’ Homes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Telerehabilitation is an effective rehabilitation method that allows patients to receive physiotherapy remotely in their homes. The purpose of this study was to investigate the effects of home-based remote group training for balance and mobility on activities and body functions. |
URŠKA PUH; | 2024-04-09 |
| 414 | Efficacy and Safety of Edaravone Dexborneol Sublingual Tablet for Post-stroke Cognitive Impairment in Patients With Acute Ischemic Stroke: A Multicenter, Randomized, Double-blind, Placebo-controlled, Exploratory Phase II Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled, exploratory Phase II clinical trial. The goal of this clinical trial is to assess the safety and efficacy of edaravone dexborneol sublingual tablets for post-stroke cognitive impairment in patients with acute ischemic stroke. Participants will be required to receive 24 weeks treatment of edaravone dexborneol sublingual tablets or placebo during this study. The safety and efficacy endpoints will be compared in the patients with edaravone dexborneol sublingual tablets or placebo. |
SIMCERE PHARMACEUTICAL | 2024-04-08 |
| 415 | AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the safety and effectiveness of IMPEDE-FX RapidFill to increase the percentage of subjects with shrinkage of the abdominal aortic aneurysm sac when used as an adjunct to on-label endovascular aneurysm repair (EVAR) stent graft treatment in trial subjects considered candidates for elective EVAR. |
MARC SCHERMERHORN; | 2024-04-05 |
| 416 | Utility of Non-standardized Clinical Swallow Evaluation Vs. Standardized Swallow Evaluation to Identify The Presence of Dysphagia and Risk for Aspiration in Patients Post-ischemic Stroke in Acute Inpatient Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare two different screening tests for detecting dysphagia (difficulty swallowing) as well as the risk for aspiration (silent swallowing of liquids/solids into the lungs) in patients after an ischemic stroke (when a blood clot blocks or narrows an artery leading to the brain). |
GEMAYARET ALVAREZ; | 2024-04-05 |
| 417 | The Effectiveness of High-intensity Laser Therapy on Plantar Flexor Muscle Spasticity in Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effectiveness of high-intensity laser therapy for treating plantar flexor muscle spasticity in subacute and chronic stroke patients, focusing on its impact on spasticity, joint range of motion, pain, muscle thickness, functional ambulation, and quality of life. |
TUĞBA ATAN; | 2024-04-05 |
| 418 | Validation of The French Translation of The Affinity for Technology Interaction (ATI) Scale Questionnaire and Assessment of The Predisposition of Healthy Adults and Stroke Survivors to Use Technological Tools in Rehabilitation PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of the study: The first aim of this study is to validate the translation of the Affinity for Technology Interaction (ATI) questionnaire. This questionnaire was developed in English by Franke, Attig and Wessel in 2019. It consists of 9 items and was developed to assess a person’s tendency to actively engage in technological interaction, or the ease with which a person uses technological tools. Currently, the questionnaire has been translated into French by our research team according to good practice recommendations (Guillemin, Bombardier and Beaton, 1993; Tsang et al., 2017), … |
LEJEUNE THIERRY; | 2024-04-04 |
| 419 | TeleABLE: Adapting A Behavioral Activation-Based Intervention to Reduce Post-Stroke Sedentary Behavior Using Telehealth (Pilot Randomized Controlled Trial) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial to test whether a remotely delivered behavioral activation-based intervention called teleABLE works better than a health education intervention for (1) reducing sitting time and (2) improving health-related quality among adults who were diagnosed with stroke within the past 12 months. Participants in this study will: * Complete questionnaires at Weeks 1, 8, and 24 * Wear an activPAL monitor at Weeks 1, 8, and 24 * Participate in the teleABLE intervention (12 sessions) or the health education intervention (6 sessions) * Complete an interview at Week 24 |
EMILY KRINGLE; | 2024-04-04 |
| 420 | Community-based Group Rehabilitation Program for Stroke Patients With Dysphagia: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Community-based exercise programs have demonstrated potential for implementation in older adults; however, it remains imperative to ascertain whether this strategy will yield comparable benefit in stroke patients with dysphagia.Participants were randomly assigned to either the intervention group or the control group. Patients in the intervention group received swallowing function training in community public spaces for 5 days every week for four-week period (60 minutes per day). Patients in the control group received no intervention. Penetration-Aspiration Scale and Standardized Swallowing Assessment (SSA), depressive symptoms (Geriatric Depression Scale-15), and meal duration were assessed before and after all the treatment. |
COPKA SONPASHAN; | 2024-04-01 |
| 421 | The Clinical Effect of TCM Sniffing Therapy Combined With Electroacupuncture in The Treatment of Cognitive Impairment After Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The patients with cognitive impairment after stroke were divided into control group, electroacupuncture group, olfactory therapy group, electroacupuncture combined with olfactory therapy group, and sham group with 35 people in each group. After the end of the treatment, the clinical efficacy was evaluated. |
XINYUN LI; | 2024-04-01 |
| 422 | The Impact of Diaphragm Training on Dysphagia in Bulbar Palsy After Ischemic Stroke: A Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a prospective multicenter study. the patients after stroke with were randomly divided into the observation group and the control group. All patients were given comprehensive rehabilitation therapy. During the treatment, enteral nutrition support was provided for the two groups by Intermittent Oro-esophageal tube feeding. The observation group will be given Diaphragm Training Nutritional status, dysphagia, quality of life and depression before and after treatment were compared. |
COPKA SONPASHAN; | 2024-04-01 |
| 423 | Efficacy of Five Strategies To Improve Stroke Awareness in The Spanish-Speaking Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this experimental study is to evaluate the efficacy of five educational strategies for recognizing early symptoms of cerebrovascular disease (CVD) in the general adult population. The main questions it aims to answer are: – How effective are the strategies RAPIDO, CORRE, DALE, CAMALEON, and ICTUS 911 in improving the recognition of early CVD symptoms? Researchers will compare these strategies to determine which one leads to the highest increase in symptom recognition. Participants will receive a brief educational session on one of the five strategies and will: * Complete a pre- and post-intervention survey (Stroke Awareness Questionnaire, … |
JUAN MANUEL MARQUEZ ROMERO; | 2024-04-01 |
| 424 | Investigation of The Effect of Modified Graded Motor Imagery Training on Upper Extremity Motor Function, Activities of Daily Living, Quality of Life and Motor Imagery Skills in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the study, movement observation training, Modified Graded Motor Imaging Training, which includes upper extremity functional exercises, and Graded Motor Imaging Training, where the standard protocol is applied, will be used in stroke patients to improve their upper extremity motor functions and daily lives. It is aimed to present it on an evidence-based basis by investigating its effects on Daily Living Activity, quality of life, upper extremity-specific right/left lateralization performance, mental stopwatch performance and motor imagery skills. |
HAVVA ADLI; | 2024-04-01 |
| 425 | Effects Of Trunk Rotation And Lateral Flexion Exercises On Peak Cough Flow And Chest Expansion In Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study we want to introduce the beneficiary combine effects of chest mobilization and chest physiotherapy exercises by using cough peak flow meter and chest expansion in stroke patients. by using theses combine exercises physiotherapist can develop target rehabilitation strategies for stroke survivors. |
ARUBA SAEED; | 2024-04-01 |
| 426 | Pilot Clinical Trial of The Risk Assessment and Personal Preference to Improve Decisions in Atrial Fibrillation Patient Decision Aid for Stroke Prevention in Atrial Fibrillation: The RAPID AFib Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot clinical trial is to evaluate the utility of a new electronic patient decision aid for stroke prevention therapy in patients with atrial fibrillation. The main questions it aims to answer are: Is the patient decision aid acceptable to both patients and physicians? Does the patient decision aid lead to more effective shared decision-making than standard care among patients with atrial fibrillation who are considering stroke prevention therapy? Participants with a recent diagnosis of atrial fibrillation will be enrolled before an upcoming specialist physician visit. Researchers will compare a pre-visit intervention consisting of standard educational materials plus use of the patient decision aid to educational materials alone to see if using the decision aid results in improved shared decision making during the clinic visit. |
STEPHEN B. WILTON; | 2024-04-01 |
| 427 | A Randomized Controlled Trial to Explore Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will be given Active Breathing Exercises. Researchers will compare dysphagia of two groups. |
ZENG CHANGHAO; | 2024-04-01 |
| 428 | Study of Percutaneous Coronary Intervention in Left Main Coronary Artery Disease in Patients With Acute Coronary Syndrome at Sohag University Hospitals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute coronary syndromes (ACS) encompass a spectrum of cardiovascular disorders characterized by the sudden onset of myocardial ischemia. They are primarily caused by atherosclerotic plaque rupture or erosion, leading to partial or complete occlusion of the coronary arteries. Among the various coronary arteries affected, left main coronary artery disease (LMCAD) is of particular concern due to its high anatomical significance and potential for adverse outcomes The left main coronary artery (LMCA) is responsible for supplying a substantial portion of the left ventricular myocardium, … |
MOHAMMED BAHAA ELDEEN ELSAYED; | 2024-04-01 |
| 429 | The Effect of Robot-assisted Gait Training on Cardiovascular Health and Activity Levels Within Early-subacute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A stroke happens when blood flow to the brain is cut off. Many people struggle to walk after having a stroke. Regaining the ability to walk is a key aim for many stroke survivors and rehabilitation practitioners as it allows improved independence and better health. This study will assess a rehabilitation method called robot-assisted gait training (RAGT) with stroke patients. RAGT uses a robotic device to assist the patient in taking steps. The RAGT device being investigated in this study is called the Lokomat. This device uses a treadmill, a harness, … |
JAMES FAULKNER; | 2024-04-01 |
| 430 | Effects of Exteroceptive and Proprioceptive Sensory Stimulation Versus Sensorimotor Therapy on Spasticity, Motor Function and Activities of Daily Living in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare effects of exteroceptive and proprioceptive sensory stimulation versus sensorimotor therapy on spasticity, motor function and activities of daily living in patients with stroke |
ZEEST HASHMI; | 2024-04-01 |
| 431 | Neural Mechanism Changes in Stroke Patients During Challenging Environments PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: For stroke patients, a challenging, unfamiliar, and more difficult task may increase the likelihood of brain activation to stimulate recovery. Pedal walking and walking with eyes-covered are both difficult and challenging tasks for stroke patients. The investigators intend to study the biomechanics and neural mechanisms of challenging pedal walking and walking with eyes covered. Stroke participants will wear electroencephalogram electrode caps and perform three tasks: walking on a flat surface for 60 seconds, walking on pedal for 60 seconds, and walking with eyes covered for 60 seconds. |
ZHAO JING; | 2024-04-01 |
| 432 | Effects of Cognitive Sensorimotor Exercises Versus Task Oriented Training on Balance ,Gait and Activities of Daily Living in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine effects of cognitive sensorimotor exercises versus task oriented training on balance, gait and activities of daily living in chronic stroke patients. |
ZEEST Z HASHMI; | 2024-04-01 |
| 433 | Analysis of Gait Parameters After Therapy Using The Tilt-table Exercise and Motor Imagery – A Randomized Observational Study on Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sixty-six stroke patients were randomly assigned to three groups (conventional, with the addition of the Erigo®Pro table, and enriched with motor imagery). The Trunk Stability Test, walking speed, step symmetry, and lower limb load symmetry on the Riablo device, as well as the superficial tension of the transverse abdominis and multifidus muscles, were assessed before and after completing therapy. |
ANNA OLCZAK; | 2024-04-01 |
| 434 | Levothyroxine Supplementation for Heart Transplant Recipients: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This will be a prospective, randomized study performed at a single tertiary referral academic medical center (University of California San Francisco, CA), evaluating the survival benefits of levothyroxine compared with no levothyroxine for patients who have undergone heart transplant. It will be double-blinded and placebo-control; participants will be randomized to receive levothyroxine or receive no levothyroxine. |
JASON SMITH; | 2024-03-29 |
| 435 | F.A.S.T.-BE FAST Consumer Stroke Warning Signs Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to learn whether the BE FAST (Balance, Eyes, Face, Arm, Speech, and Time) acronym works at least as well or better than the F.A.S.T. (Face drooping, Arm weakness, Speech difficulty, Time to call 911) acronym in helping participants learn and remember the warning signs of a stroke. The main questions it aims to answer are: – Does the BE FAST acronym increase understanding among participants that calling 911 is the right first step they should take if a stroke is suspected? – … |
AMERICAN HEART ASSOCIATION | 2024-03-28 |
| 436 | R3THA Rehabilitation Feasibility and Usability Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess how the Rehabilitation Technologies for Hand and Arm (R3THA) device can be used for rehabilitation of people with stroke. the study will evaluate the feasibility of R3THA as outpatient telerehabilitation administered by trained clinicians to individuals with stroke. |
KIRAN KARUNAKARAN; | 2024-03-27 |
| 437 | Neurological Recovery of The Paretic Lower Limb and Balance and Walking Abilities in The Subacute Phase of Stroke in Patients Hospitalized in Medical and Rehabilitation Units: A Prospective Multicenter Longitudinal Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to describe the evolution of gait recovery during the subacute phase of stroke up to six months after stroke, in patients hospitalized in medical and neurological rehabilitation units. |
CHRISTOPHE T DURET; | 2024-03-26 |
| 438 | The Effect of Fluid Loading With Early Norepinephrine Administration on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The complexity of pediatric septic shock arise from its varied pathophysiology, which includes systemic inflammation, cardiovascular collapse, and multiple organ dysfunction. Current standard treatments, which primarily focusedon fluid resuscitation, had exhibited several problems. Excessive fluid resuscitation has been associated with complications such as fluid overload, which may cause conditions such as pulmonary edema and organ dysfunction, leading to worsened outcomes. This emphasizes the need for alternative therapeutic strategies that can effectively manage hemodynamic instability while minimizing the risks of fluid overload. In adult patients, the early use of vasopressors has been recommended to restore perfusion in patients with septic shock, … |
INDONESIA UNIVERSITY | 2024-03-25 |
| 439 | The Effect of Virtual Reality Treadmill-Based Gait Training on Gait and Balance Ability in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Walking independence is one of the most important goals for stroke patients and a major factor influencing their return to society after the onset of stroke. Stroke patients experience walking difficulties due to hemiplegia and have an increased risk of falls due to impaired balance ability. Recent studies have shown that treadmill-based walking training incorporating virtual reality can help improve walking and balance functions in actual stroke patients. However, there are few randomized clinical trials with control groups, highlighting the need for further research to ensure the reliability of clinical effects. Therefore, … |
YONSEI UNIVERSITY | 2024-03-25 |
| 440 | The Improve Acute Reperfusion Treatment Quality for Ischemic Stroke Through Spatiotemporal Computing in China (IMPROVE-II ) -A Multicenter, Evaluator-Blind, Cluster-Randomized Controlled Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study intends to construct the goal-oriented integrated intervention model for AIS in-hospital procedure through the spatiotemporal positioning and the P-D-C-A cycle for continuous improvement (FAST model). Then a multicenter, evaluator-blind, cluster-randomized controlled study aims to verify the validity and safety of this FAST model. |
ZI-XIAO LI; | 2024-03-18 |
| 441 | Somatosensory Evoked Potential (SEP) N20 Monitoring With BraiN20® Medical Device for Prediction of Functional Independence Defined As Rankin Scale Score 0-2 in Global Patients With Suspected Acute Stroke PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Time is Brain company (http://www.tibtimeisbrain.com/about_us/) developed BraiN20®, a medical device to assess the presence and characteristics of the N20 signal of SEP. Investigators have demonstrated a high prognostic accuracy of N20 on functional recovery of patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) undergoing endovascular thrombectomy (EVT), … |
ALICIA MARTÍNEZ PIÑEIRO; | 2024-03-15 |
| 442 | The Comparison of Treatment Results Between Cerebellar DBS and Vagus Stimulation for Post-stroke Motor Rehabilitation: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts.In this open-label, randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with bilateral or unilateral stimulation. Vagus nerve stimulation was also conducted for motor function after ischaemic Stroke.We hypothesized that cerebellar stimulation was superior to vagus stimulation as the motor rehabilitation after stroke benefits from both side of cerebellum. |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2024-03-15 |
| 443 | Effect of Neuromuscular Stimulation and Mindfulness Breathing on Pulmonary, Physical Functions and Stress in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is an interventional study in which 60 stroke patients were estimated to enroll according to random allocation and divided into two groups. The experimental group will receive neuromuscular stimulation and mindfulness breathing, while the control group will receive neuromuscular stimulation only. |
MARWA MAHMOUD ELSAYED MAHMOUD; | 2024-03-15 |
| 444 | Effects of Local Vibrations Program of Dorsiflexor Muscles on Neuromotor Recovery in Subacute Stroke Patients – A Multicentric Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the vibration intervention proposed in the current study is to allow a better neuromotor recovery in subacute stroke patients when compared with standard rehabilitation alone. These last years, it has been proven that the solicitation of a muscle using vibrations may lead to positive effects on the neuromuscular function. Thus, … |
BRUNO FERNANDEZ; | 2024-03-12 |
| 445 | Effects of Core Strengthening and PNF Pattern on Static Balance and Plantar Pressure in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a neurological disease characterized by neurological deficits caused by insufficiency of blood supply to brain. Disruption of blood supply to brain can be due to blockage of blood supply (ischemic) or leakage of blood in brain due to rupture of blood vessel (hemorrhagic). 90.5% of global occurrence of stroke was subjected to modifiable risk factors according to Global Burden of Disease study. This study aims to compare the effects of core strengthening and proprioceptive neuromuscular facilitation on static standing balance and plantar pressure in chronic stroke patients. |
SAFA SALEEM; | 2024-03-10 |
| 446 | Effect of Strength Training of Non-paretic Upper and Lower Limb With or Without Mirror Therapy on Motor Function Recovery of The Pareytic Side in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to find the effects of strength training with or without mirror therapy of non-paralytic upper limb for functional activities and in lower limb for gait pattern, balance and stability, and ADLs of paralytic side in patients with acute and sub-acute stroke. A randomized controlled trial that will include total 44 participants .The control group will undergo usual rehabilitation training along with strength training. The trial group will undergo strength training and mirror therapy of NHS on the basis of usual rehabilitation training. For the control group, training time will be 30 minutes, … |
SARA AABROO AABROO; | 2024-03-10 |
| 447 | A Prospective, Multicenter, Registry Study to Evaluate The Safety, Efficacy, and Standardized Procedural Optimization of The Intracranial Drug-Eluting Stent System in Patients with Symptomatic Intracranial Atherosclerotic Stenosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this trial is to evaluate the Safety, Efficacy, and Standardized Procedural Optimization of the Intracranial Drug-Eluting Stent System in Patients with Symptomatic Intracranial Atherosclerotic Stenosis. |
SHENG GUAN; | 2024-03-08 |
| 448 | Effects of Robot-Assisted Rehabilitation on Upper Extremity Functions and Activities of Daily Living in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The most common problem caused by stroke is motor activity limitation that reduces muscle movement and mobility. But stroke can also lead to sensory and cognitive impairment. Additionally, the ability to independently carry out activities of daily living and participate in social and community life is greatly reduced. Up to 85% of stroke patients experience hemiparesis immediately after stroke, while 55% to 75% of survivors continue to experience reduced quality of life with motor impairments. It requires long-term physical rehabilitation to achieve functional recovery in the upper extremity, … |
FATIH TEKIN; | 2024-03-07 |
| 449 | Coated or Chewable Aspirin in Patients with Established Atherosclerotic Disease and A Hybrid Strategy to Mitigate The Adverse Effects of Air Pollution: The COATED-AIR Randomized Clinical Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Although both enteric-coated and plain formulations of aspirin are being used commonly, there are no high-quality comparisons between these formulations with respect to clinical efficacy outcomes in patients with atherosclerotic cardiovascular diseases (ASCVD). Air pollution is also a major contributor to the excess risk of cardiovascular events in many regions of the world. However, … |
PARHAM SADEGHIPOUR; | 2024-03-06 |
| 450 | Feasibility of Trigeminal and Vagus Nerve Stimulation in Subjects With Chronic Upper Extremity Deficits After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, pilot study of up to 25 subjects with residual upper extremity deficits at least six months after an ischemic stroke. The purpose of the study is to evaluate the initial clinical safety, device functionality, and treatment effect of non-invasive electrical stimulation of the trigeminal and/or vagus nerves (nTVNS) using the NeuraStasis Stimulator System adjunctive to rehabilitation. Subjects will either receive the intervention or control-sham stimulation. The study will inform the design and implementation of a pivotal study. |
SEAN SAVITZ; | 2024-03-05 |
| 451 | Immersive Versus Non-immersive Virtual Reality in Enhancing Upper Limb Functions Among Individuals With Subacute Stage Hemiplegia – A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to compare the effectiveness of immersive virtual reality combined with conventional therapy to the effectiveness of non-immersive virtual reality combined with conventional therapy in enhancing upper limb function in subacute hemiplegic stroke patients. |
ATHIRA GEORGE; | 2024-03-05 |
| 452 | Immediate Effects of Open and Closed Kinetic Chain Activities on Upper Extremity Spasticity and Motor Dexterity in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a sudden disruption of blood flow to the brain, resulting in physical and mental disabilities. It’s a global health issue affecting millions each year, often leading to paralysis, altered muscle tone, and loss of motor control and balance. This study aims to examine the immediate effects of open and closed kinetic chain activites on upper extremity spasticity and motor dexterity in hemiplegic patients. This study will be conducted simultaneously at İstinye University Hospital Medical Park Gaziosmanpaşa and İstinye University Physiotherapy and Rehabilitation Application and Research Center (İSÜFİZYOTEM). 50 stroke patients will be included in the study, … |
ÇIÇEK GÜNDAY; | 2024-03-04 |
| 453 | The Effect of SRS on Hemiplegia in Stroke Survivors: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Strokes are one of the leading causes of long term disability and death in the United States. A stroke occurs when the blood supply to the brain is blocked, damaging parts of the brain. Many stroke survivors have difficulty completing dexterous hand movements and manipulating objects due brain damage in the sensorimotor cortex. Damage to these areas can cause decreased motor movements and tactile sensation on the affected side. Research shows that tactile sensation is necessary for maintaining grip, grading grip forces and decreasing object slippage. Therefore, … |
VIRGINIA CHU; | 2024-03-04 |
| 454 | Multi-center International Observational Study of Efficiency of The Drug Cytoflavin®, Solution for Infusions in Patients With Ischemic Stroke Not Receiving Reperfusion Therapy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke remains one of the main socially significant problems in the healthcare in the third millennium. The lethality in persons with history of stroke by the end of the 1st year of disease is high. A trend to increased frequency of stroke in the young age is observed during the last decade; third of patients is working-age individuals, out of whom only 15-20% returns to labor, and others remain disabled persons requiring constant medical and social support |
POLYSAN SCIENTIFIC & TECHNOLOGICAL PHARMACEUTICAL COMPANY | 2024-03-01 |
| 455 | Adaptation and Validation Study of The Longer- Term Unmet Needs After Stroke Questionnaire Into Turkish PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: According to the most up-to-date knowledge, there is no Turkish comprehensive and validated instrument to assess stroke survivors’ unmet needs in the longer term. So, this study aims to translate and adapt the LUNS into Turkish and examine its psychometric properties in survivors living at home after a stroke. Our hypothesis in this study is: – The Turkish Longer-term Unmet Needs after Stroke Questionnaire (T-LUNS) is a valid tool for assessing the unmet needs of stroke patients in the Turkish population. |
ALI YAVUZ KARAHAN; | 2024-03-01 |
| 456 | TO STUDY THE EFFECTIVENESS OF RECOVERY IN PATIENTS WITH CEREBRAL STROKE THROUGH THE USE OF THE REHAND REHABILITATION SYSTEM PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to investigate the efficacy of the ReHand rehabilitation system for the recovery of patients after a stroke. The main objectives of the study: 1. To assess the functional state of patients with cerebral stroke according to the The Barthel Index, on the Functional Independence Measure (FIM) scale of functional independence. 2. To assess the neurological deficit of patients according to the National Institutes of Health Stroke Scale (NIHSS), the state of function of the affected arm and the degree of fine motor impairment according to the The Frenchay Arm Test (FAM), … |
KARAGANDA MEDICAL UNIVERSITY | 2024-03-01 |
| 457 | A Randomized Controlled Trial To Explore The Effect of Oral Vs. Nasal Enteral Nutrition Tube Feeding on Stroke Survivors in Social Interaction and Psychological Status PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore Clinical Effect of Intermittent Oro-esophageal Tube Feeding in Dysphagic Stroke Survivors. The main questions it aims to answer are: Can Intermittent Oro-esophageal Tube Feeding improve psychological status in Dysphagic Stroke Survivors? Can Intermittent Oro-esophageal Tube Feeding improve social interaction in Dysphagic Stroke Survivors? Patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, … |
AHMADU BELLO UNIVERSITY TEACHING HOSPITAL | 2024-03-01 |
| 458 | Comparison of Oral and Nasal Tube Feeding on Stroke-related Dysphagia: A Prospective Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a prospective multicenter study. the patients after stroke with were randomly divided into the observation group and the control group. All patients were given comprehensive rehabilitation therapy. During the treatment, enteral nutrition support was provided for the two groups by Intermittent Oro-esophageal tube feeding and nasogastric tube feeding, respectively. Nutritional status, dysphagia, quality of life and depression before and after treatment were compared. |
MUHAMMAD | 2024-03-01 |
| 459 | Interventional Ventricular Assist System for PCI in Complicated and High-risk Patient: A Prospective, Multicenter, Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In patients with complex coronary artery disease (CAD), determining the optimal revascularization strategy (percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) remains a challenge. These high-risk patients pose an extreme surgical risk. However, with the development of new interventional techniques and materials, PCI is a good alternative to CABG and is referred to as complex high-risk indicated PCI (CHIP). During CHIP, … |
XIJING HOSPITAL | 2024-03-01 |
| 460 | Effects of Repetition Home-based Constraint Induced Movement Therapy (CIMT) Compared With Repetition Clinic-based CIMT on Outcomes Post Stroke: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Constraint induced movement therapy (CIMT) is based on the theoretical basis that constraining the unaffected limb following injury of the brain such as stroke can help overcome learned non-use. It comprises of constraint of the unaffected limb, massed tasks practice with the affected limb and a behavioral contract known as the transfer package whereby use of the affected limb is extended to the real-world situations. home-based rehabilitation is likely to be cost-effective, and it may reduce cost for patients in terms of hospital charges and transport fares. However, … |
SHAMAY NG; | 2024-03-01 |
| 461 | A Randomized Controlled Trial to Explore The Effect of Different Feeding Modes on Psychological Condition and Experience in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the differences on Psychological Condition and Experience in ischemic stroke patients using Intermittent Oro-esophageal Tube and Nasogastric Tube. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will use Intermittent Oro esophageal Tube for enteral nutrition support, while the control group will use Nasogastric Tube. Researchers will compare Psychological Condition and Experience of two groups. |
COPKA SONPASHAN; | 2024-03-01 |
| 462 | NewGait: A Low-Cost Rehabilitation System to Improve Post-Stroke Gait (Biomechanical Adaptations) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An affordable and easy to use gait-assistive device for stroke survivors to use at home is yet to be developed. This study is intended to modify the current design of the NewGait device to specifically work for stroke survivors based on feedback from patients and clinicians. Consequently, conducting a short-term biomechanical gait study is planned to determine the usability and functionality of the NewGait device compared to other comparative devices. |
CHANDRAMOULI KRISHNAN; | 2024-03-01 |
| 463 | A Randomized Controlled Trial to Explore The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will be given Active Breathing Exercises. Researchers will compare dysphagia of two groups. |
COPKA SONPASHAN; | 2024-03-01 |
| 464 | The Therapeutic Effect of Computer-based Training on Cognitive Dysphagia in Stroke Survivors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter randomized controlled study. The study recruited stroke patients with mild cognitive impairment and dysphagia who were undergoing inpatient rehabilitation treatment in three hospitals in mainland China as the participants (study subjects). The study duration for each participant was 15 days. The subjects were randomly divided into an experimental group and a control group. During the treatment, all patients received routine rehabilitation treatment. In addition, patients in the control group received conventional cognitive training, while patients in the experimental group received computer-assisted cognitive training. |
COPKA SONPASHAN; | 2024-03-01 |
| 465 | FNIRS Study of Effort-dependent Brain Activations During Pointing Movements of The Upper Limb in Post-stroke Patients and Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Upper limb paresis is the most common motor deficit following a stroke, and its long-term persistence has an impact on patients’ functional recovery and quality of life. Rehabilitation is therefore a major challenge in restoring functional independence. New physical treatments have been developed over the last 20 years to optimize motor relearning by intensifying motor rehabilitation; among them, therapy using robotic devices has shown its effectiveness in reducing motor deficits. This therapy offers various options ranging from assistance to movement resistance, … |
CLINIQUE LES TROIS SOLEILS | 2024-03-01 |
| 466 | Clinical Effect of Acupuncture Technique for Restoring Consciousness Combined With Scalp Acupuncture on Post-stroke Dysphagia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled study, including post-stroke dysphagic patients. The participants were divided randomly into the experimental group and the control group. Both two groups were given routine treatment and swallowing rehabilitation training. Moreover, the experimental group was given Acupuncture Technique for Restoring Consciousness. Swallowing function will be compared before and after treatment. |
COPKA SONPASHAN; | 2024-03-01 |
| 467 | Prognostic Factors for Surgical Management of Large Hypertensive Basal Ganglionic Haemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to present current and comprehensive recommendations for surgical treatment of this hematoma and to determine the factors that may improve the survival rate |
AHMED SAMEEH; | 2024-03-01 |
| 468 | Evaluating Efficacy and Safety of Auricular Acupuncture in Treating Insomnia Post-stroke: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if Auricular acupuncture works to treat Insomnia Post-stroke patients. It will also learn about the safety of Auricular. The main questions it aims to answer are: – Does Auricular acupuncture reduce the time it took participants to fall asleep? – Dose Auricular acupuncture increase the number of hours participants slept? – Dose Auricular acupuncture improve sleep quality as measured by The Pittsburgh Sleep Quality Index (PSQI)? – … |
NGUYEN THI THUY AN; | 2024-03-01 |
| 469 | A Randomized Controlled Study to Explore The Effect of Intermittent Oro-esophageal Tube on Rehabilitation Therapy Compliance in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to compare Rehabilitation Therapy Compliance of ischemic stroke patients who receive enteral nutrition support through either Intermittent Oro-esophageal Tube or Nasogastric Tube. Patients will be randomly assigned to either an observation group or a control group, with both groups receiving routine rehabilitation treatment. The observation group will receive enteral nutrition support through Intermittent Oro-esophageal Tube, while the control group will receive it through Nasogastric Tube. Researchers will then compare Rehabilitation Therapy Compliance of the two groups. |
COPKA SONPASHAN; | 2024-03-01 |
| 470 | A Randomized Controlled Trial to Explore The Effect of Intermittent Oro-esophageal Tube on Feeding Amount PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the differences in feeding amount and nutritional status between ischemic stroke patients using Intermittent Oro-esophageal Tube and Nasogastric Tube. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will use Intermittent Oro esophageal Tube for enteral nutrition support, … |
COPKA SONPASHAN; | 2024-03-01 |
| 471 | The Impact of Oral and Nasal Enteral Nutrition Feeding Quantity in Stroke Patients: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the differences in feeding amount and nutritional status between ischemic stroke patients using Intermittent Oro-esophageal Tube and Nasogastric Tube. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will use Intermittent Oro esophageal Tube for enteral nutrition support, … |
MUHAMMAD | 2024-03-01 |
| 472 | Intermittent Oro-esophageal Tube on Rehabilitation Therapy Compliance in Stroke Patients: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to compare Rehabilitation Therapy Compliance of ischemic stroke patients who receive enteral nutrition support through either Intermittent Oro-esophageal Tube or Nasogastric Tube. Patients will be randomly assigned to either an observation group or a control group, with both groups receiving routine rehabilitation treatment. The observation group will receive enteral nutrition support through Intermittent Oro-esophageal Tube, while the control group will receive it through Nasogastric Tube. Researchers will then compare Rehabilitation Therapy Compliance of the two groups. |
ZENG CHANGHAO; | 2024-03-01 |
| 473 | Clinical Trial Evaluating The Effect of Tranexamic Acid on The Clinical Outcomes in Pediatric Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the effect of tranexamic acid on mortality in pediatric patients with traumatic brain injury. This could potentially lead to improved treatment protocols and better outcomes for this vulnerable population. |
NOHA MANSOUR; | 2024-03-01 |
| 474 | Comparative Effects of Intensive and Distributed Constraint-induced Movement Therapy on Upper Extremity Function in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main question this clinical trial is aims to answer is whether intensive and distributed constraint-induced movement therapy has similar effects on upper extremity function in participants with stroke. Participants will receive intensive protocol of CIMT for 6 hours for 6 days to make total of 36 hours while distributed protocol participants will receive 2.25 hours of training two times a week for 8 weeks making total of 36 hours. |
WAJIHA SHAHID; | 2024-03-01 |
| 475 | Combining Transcranial Direct Current Stimulation With Intermittent Oral to Esophageal Tube for Stroke-related Dysphagia Management: Double Blind Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a double-blind randomized controlled trial, lasting for 15 days for each participant. Patients with post-stroke dysphagia who receive treatment at the Rehabilitation Department are selected as the study subjects. The patients are randomly assigned to either the experimental group or the placebo group. All patients receive routine rehabilitation therapy and swallowing rehabilitation training, along with enteral nutrition support using Intermittent Oro-esophageal Tube. In addition to these interventions, patients in the experimental group receive transcranial direct current stimulation, while the instruments used for patients in the placebo group only illuminate an indicator light without any actual effect. |
COPKA SONPASHAN; | 2024-03-01 |
| 476 | The Impact of Myofascial Release Therapy on Dysphagia in Post-stroke Patients: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore Clinical Effect of Myofascial Release Therapy in Dysphagic Stroke Survivors. The main question it aims to answer is: • Can Myofascial Release Therapy improve swallowing function in Stroke Survivors? Patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given Myofascial Release Therapy. The study lasts 21 days for each patient. Researchers will compare the Functional Oral Intake Scale, Penetration-Aspiration Scale, Swallowing Quality of Life to see if the Myofascial Release Therapy can help improve the situation. |
COPKA SONPASHAN; | 2024-03-01 |
| 477 | Effectiveness of Soft Robotic Glove Versus EMS on Hand Function and Quality of Life in Stroke Survivors. A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effectiveness of soft robotic gloves versus electrical muscle stimulation (EMS) in improving hand function and quality of life in stroke survivors. Stroke often leads to impaired hand mobility, impacting daily activities and reducing overall quality of life. Soft robotic gloves, designed to assist with hand movement, will provide mechanical support and encourage voluntary muscle activity. EMS, on the other hand, will stimulate muscle contraction through electrical impulses, potentially enhancing muscle strength and coordination. |
MUHAMMAD NAVEED BABUR; | 2024-03-01 |
| 478 | Intermittent Oro-esophageal Tube Feeding Vs. Nasogastric Tube Feeding on Dysphagia Patients After Stroke: A Prospective Multicenter Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a prospective multicenter study. the patients after stroke with were randomly divided into the observation group and the control group. All patients were given comprehensive rehabilitation therapy. During the treatment, enteral nutrition support was provided for the two groups by Intermittent Oro-esophageal tube feeding and nasogastric tube feeding, respectively. Nutritional status, dysphagia, quality of life and depression before and after treatment were compared. |
COPKA SONPASHAN; | 2024-03-01 |
| 479 | Intermittent Oro-esophageal Tube on Feeding Hesitancy in Stroke Patients: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to compare Feeding Hesitancy of ischemic stroke patients who receive enteral nutrition support through either Intermittent Oro-esophageal Tube or Nasogastric Tube. Patients will be randomly assigned to either an observation group or a control group, with both groups receiving routine rehabilitation treatment. The observation group will receive enteral nutrition support through Intermittent Oro-esophageal Tube, while the control group will receive it through Nasogastric Tube. Researchers will then compare Feeding Hesitancy of the two groups. |
MUHAMMAD | 2024-03-01 |
| 480 | A Double-blind Randomized Controlled Study to Explore Effectiveness of Stellate Ganglion Block in Managing Dysphagia in Patients With Medullary Infarction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine. All patients are randomly allocated to the observation group or the control group. Both groups are provided with comprehensive rehabilitation. Besides, the observation group additionally undergoes the stellate ganglion block. At admission and after 10-day treatment, video fluoroscopic swallowing study, and penetration-aspiration scale, Functional Oral Intake Scale, Flexible laryngoscope are used to assess swallowing function. |
AHMADU BELLO UNIVERSITY TEACHING HOSPITAL | 2024-03-01 |
| 481 | Effect of Computer-based Cognitive Function Training on Cognitive Dysphagia After Stroke: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter randomized controlled study. The study recruited stroke patients with mild cognitive impairment and dysphagia who were undergoing inpatient rehabilitation treatment in three hospitals in mainland China as the participants (study subjects). The study duration for each participant was 15 days. The subjects were randomly divided into an experimental group and a control group. During the treatment, all patients received routine rehabilitation treatment. In addition, patients in the control group received conventional cognitive training, while patients in the experimental group received computer-assisted cognitive training. |
MUHAMMAD | 2024-03-01 |
| 482 | A Randomized Controlled Trial to Explore The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will be given Active Breathing Exercises. Researchers will compare dysphagia of two groups. |
ZENG CHANGHAO; | 2024-03-01 |
| 483 | A Randomized Controlled Study to Explore The Effect of Stellate Ganglion Block in Dysphagic Patients With Bulbar Palsy After Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine in 3 hospitals in China. All patients are randomly allocated to the observation group or the control group. Both groups are provided with comprehensive rehabilitation. Besides, the observation group additionally undergoes the stellate ganglion block. At admission and after 10-day treatment, video fluoroscopic swallowing study, and penetration-aspiration scale, Functional Oral Intake Scale, Flexible laryngoscope are used to assess swallowing function. |
COPKA SONPASHAN; | 2024-03-01 |
| 484 | A Prospective, Single-center, Single-arm Clinical Study to Evaluate The Safety and Effectiveness of Percutaneous Intramyocardial Septal Radiofrequency Ablation System in The Treatment of Hypertrophic Obstructive Cardiomyopathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypertrophic cardiomyopathy (HCM) is a common clinical genetic-related disease, with a global incidence of 0.2%-0.5%, but only a few cases (10-20%) have been clinically diagnosed. About 70% of them are hypertrophic obstructive cardiomyopathy (HOCM), these HOCM patients have significant clinical symptoms, including progressively increasing fatigue, angina, exertional dyspnea, and syncope. Conservative medications are used to treat the vast majority of patients. Invasive therapy, which includes surgical myectomy, percutaneous transluminal septal myocardial ablation(PTSMA), percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) and percutaneous endocardial septal radiofrequency ablation (PESA) is introduced to patients with refractory symptoms or drug resistance. However, … |
SUZHOU SINUS MEDICAL TECHNOLOGIES | 2024-02-29 |
| 485 | A Randomized Controlled Trial to Explore The Effect of Different Feeding Modes on Psychological Condition and Experience in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the differences on Psychological Condition and Experience in ischemic stroke patients using Intermittent Oro-esophageal Tube and Nasogastric Tube. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will use Intermittent Oro esophageal Tube for enteral nutrition support, while the control group will use Nasogastric Tube. Researchers will compare Psychological Condition and Experience of two groups. |
ZENG CHANGHAO; | 2024-02-28 |
| 486 | Cognitive-motor Training on A Labile Surface in Stroke Inpatients: Feasibility and Preliminary Effects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of this study is to assess the feasibility and effects of exergame-based cognitive-motor training on a labile platform on physical and cognitive functioning in stroke inpatients. This is two-armed pilot randomized controlled trial taking place in an inpatient neurologic rehabilitation clinic. A total of 30 persons that are undergoing inpatient rehabilitation due to a stroke will be randomly assigned to either the intervention group (IG) or the control group (CG). Participants of the IG will receive exergame-based motor-cognitive training on a labile surface, … |
ELEFTHERIA GIANNOULI; | 2024-02-28 |
| 487 | Effectiveness of Virtual Reality in Patients With Symptomatic Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One of the main challenges facing the therapist in the treatment of adhesive capsulitis is to motivate the patient throughout conventional therapy. As noted in a recent review, individuals are more interested in leisure activities rather than performing repetitive tasks during therapy. Virtual reality (VR) is a three-dimensional computer-aided programme built with a system that creates virtual reality movements and generates a high amount of visual and sensory feedback during exercise. As a result, virtual reality (VR) has been used in many medical indications and has been shown to promote adherence to treatment by increasing patient motivation. |
BASAK CIGDEM KARACAY; | 2024-02-28 |
| 488 | Comparing The Effectiveness of Traditional Physiotherapy Combined With Virtual Reality for Post-Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effectiveness of combining virtual reality (VR) therapy with traditional physiotherapy in post-stroke rehabilitation. Post-stroke patients often suffer from impairments in motor function, balance, and overall quality of life. While traditional physiotherapy is a widely accepted method for stroke recovery, incorporating VR technology may enhance treatment outcomes by providing an engaging, immersive environment that motivates patients to perform therapeutic movements. |
MUHAMMAD NAVEED BABUR; | 2024-02-28 |
| 489 | Analysis of The Correlation Between Ultrasound and Functional Parameters in The Medial Gastrocnemius Muscle in Post-stroke Patients With Spasticity in The Lower Limb PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to understand the impact of spasticity on muscle changes and functional performance in stroke patients with lower limb spasticity in comparison to non-stroke individuals. The main questions it aims to answer are: – How does spasticity affect muscle changes and lower limb functional performance in stroke patients? – … |
PABLO HERRERO GALLEGO; | 2024-02-27 |
| 490 | Evaluation of Cardiovascular Risk After Preeclampsia in General Practitioners and Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pre-eclampsia is a disease characterized by placental damage leading to a cascade of complications during pregnancy. It is initially manifested by high blood pressure and the presence of albumin in the urine. It can lead to emergency hospitalization in severe cases and cause major complications or even death in the mother and the fetus. Several studies observing the outcome of patients with pre-eclampsia have shown an increased long-term cardiovascular risk in these patients, justifying regular medical follow-up with the treating physician and specialists, … |
JEAN-MARC BOIVIN; | 2024-02-26 |
| 491 | Effect of Transcranial Direct Current Stimulation Versus Pilates Based Core Stability Training on Balance and Gait in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effects of transcranial direct current stimulation and pilates based core stability training on gait and balance in stroke patients. The main question[s] it aims to answer are: – is there an effect of transcranial direct current stimulation and pilates based core training on gait and balance – Is there a significant effect of tDCS over Pilates-based core training Participants will be assigned to three groups: – Group 1: will receive 18 sessions(3 sessions/week 20 minutes each) of anodal tDCS in addition to conventional physical therapy exercises – … |
AISHA MOHAMED KHALED AHMED SALEH; | 2024-02-25 |
| 492 | Comparison of Modified-Otago and Tai Chi Exercises on Balance and Motor Function in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to determine the comparative effects of Modified-Otago and Tai Chi Exercises on Balance and Motor Function in Patients with Stroke. |
RIPHAH INTERNATIONAL UNIVERSITY | 2024-02-25 |
| 493 | Comparative Effects of Motor Imagery and Mirror Therapy Versus Motor Relearning Program on Balance, Motor Function and Activities of Daily Living in Subacute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Use of motor imagery, mirror therapy and motor relearning program in rehabilitation of people with stroke is on rise and these are unique and emerging techniques. Motor imagery is a mental rehearsal through visualization while mirror therapy creates a reflection of non-effected limb by using a mirror. Moreover, motor relearning is task-oriented approach, benefacial for balance and motor funCtion in patients with stroke that emphasizes on relearning.The aim of the study is to determine the comparative effects of motor imagery and mirror therapy versus motor relearning program in addition to routine physical therapy on balance, … |
RIPHAH INTERNATIONAL UNIVERSITY | 2024-02-25 |
| 494 | Combined Effects of Virtual Reality and Motor Imagery Techniques With Routine Physical Therapy on Balance, Motor Function and Activities of Daily Living in Post Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke a devastating neurological condition, causing severe neurological challenges such as balance issues, motor function and cognitive deficits among survivors and can cause disability and death. The use of Virtual Reality and Motor Imagery in rehabilitation of neurologic disorders is on the rise. In stroke patients, VR and MI combination has not been studied. This study aims to investigate the combined effects of Virtual Reality and Motor Imagery Techniques with Routine Physical Therapy in patients with post stroke patients. |
RIPHAH INTERNATIONAL UNIVERSITY | 2024-02-25 |
| 495 | Effect of Dual-task Training on The Number of EEG Band in Stroke Patients Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a prevalent global health concern, causing widespread disability as it disrupts blood supply to the brain, leading to functional impairments. Upper limb dysfunction affects over 80% of stroke survivors acutely and becomes permanent in approximately 60%, hindering daily activities and autonomy. Dual-task training (DTT), involving simultaneous cognitive and motor tasks resembling daily activities, is proposed as an effective intervention. The study suggests using electroencephalogram (EEG) analysis, particularly the Fast Fourier Transform (FFT), to assess changes in brain signals pre- and post-DTT intervention. EEG provides real-time insights into brain function, … |
PABLO HERRERO GALLEGO; | 2024-02-25 |
| 496 | Comparative Effects of Virtual Reality and Frenkel’s Exercises on Balance, Gait and Quality of Life in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the effects of Virtual reality and Frenkel’s exercises on balance, gait and quality of life in patients with stroke. |
ALVEENA FATIMA; | 2024-02-20 |
| 497 | A Single-blind Randomized Controlled Trial of Multisensory Stimulation Virtual Reality to Improve Motor and Cognitive Function in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a single-blind randomized controlled trial of multisensory stimulation virtual reality to improve motor and cognitive dysfunction in stroke patients. |
DINGQUN BAI; | 2024-02-20 |
| 498 | Physiological and Functional Effects of Percutaneous Neuromodulation Vs Transcutaneous Neuromodulation in The Clubfoot Approach in Post-stroke Patients. Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: INTRODUCTION: Clubfoot, drop foot or clubfoot, is a disorder that prevents reaching 100º of dorsiflexion actively. Its etiology is varied, and may be due to congenital problems, direct alteration of the bone structure, spasticity or shortening of the posterior musculature (triceps suralis), a neurological factor or a combination of several. Thus, we can differentiate between congenital clubfoot and acquired clubfoot. Stroke is one of the main causes of acquired clubfoot, … |
ALEJANDRO CAÑA PINO; | 2024-02-16 |
| 499 | Early Intensive Antihypertensive Treatment in High-risk Population of Intracerebral Hemorrhage Expansion Predicted By Artificial Intelligence PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to clarify the efficacy, safety and feasibility of early intensive antihypertensive treantment in intracerebral hemorrhage (ICH) patients at high risk of hematoma expansion based on artificial intelligence prediction. The main question it aims to answer are: – Can ICH patients at high risk of hematoma expansion based on artificial intelligence prediction benefit from early intensive antihypertensive treatment? – … |
NA LI; | 2024-02-15 |
| 500 | Comparative Impact of Rhythmic Auditory Stimulation Therapy and Task Specific Training for Improving Motor Functions in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the effectiveness of Rhythmic Auditory Stimulation (RAS) therapy versus Task-Specific Training (TST) in enhancing motor function recovery in stroke patients. RAS uses rhythmic cues to aid movement synchronization, while TST focuses on practicing daily tasks to improve functional ability. In a randomized clinical trial, participants were assigned to either RAS or TST groups, with both receiving structured sessions over several weeks. |
MUHAMMAD NAVEED BABUR; | 2024-02-15 |