Clinical Digest: Recent Clinical Trials on Traumatic Brain Injury
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Traumatic Brain Injury. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Traumatic Brain Injury
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective randomized controlled trial comparing two different physical therapy approaches to the treatment of posttraumatic headache with autonomic symptoms. AIM 1: To establish the efficacy of SPINEPASS against Standard Physical Therapy to reduce headache disability and impact amongst patients with persistent post-concussion headache. AIM 2: Demonstrate the superiority of SPINEPASS in the efficient self-management of headache. Demonstrate its appropriateness, acceptability, and feasibility and gain patient insights among patients with PPTH compared to standard PT. |
LUCY THOMAS; | 2025-05-01 |
| 2 | Biomarker Role in Assessing Imaging Needs for Mild Cranial Trauma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine whether a blood test can help doctors decide when to use a head CT scan for patients with a mild head injury. Researchers are investigating whether the results from this blood test can aid in making better decisions about patient care and potentially reduce the need for imaging. In this study, … |
JONATHAN A. GROSSBERG; | 2025-05-01 |
| 3 | Viscoelastic Tests (VET) Versus Conventional Coagulation Tests (CCT) for Management of Trauma-Induced Coagulopathy: Opened, Randomized, Two-Parallel, Controlled Trial.VISCOTAC PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic coagulopathy is a complex, multifactorial event that occurs in 20-30% of patients on admission. It increases mortality, and its treatment is one of the main priorities in the early management of severely injured patients. Diagnosis of coagulopathy has traditionally been based on conventional coagulation tests (CCTs), which provide an assessment of patients’ coagulation in over 60 minutes. Over the past fifteen years, viscoelastic tests (VETs) have been proposed, providing a more rapid result (≤ 10 min) and can guide the administration of labile blood products (LBP). Various studies, mainly retrospective, … |
HOSPICES CIVILS DE LYON | 2025-05-01 |
| 4 | Ubiquitin C-terminal Hydrolase L1 (UCH-L1) and Glial Fibrillary Acidic Protein (GFAP) As Acute Biomarkers for Prediction of Traumatic Brain Injury (TBI) in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to establish if Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) are predictive of computed tomography (CT) findings in pediatric traumatic brain injuries (TBI). The participant population is pediatric patients, ages 0 to less than 18 years old with a possible TBI or trauma-related injury who have blood drawn per standard of care in the emergency department. Blood samples will be analyzed using the i-STAT TBI cartridge (Abbott Laboratories, Abbott Park, IL, … |
GRACE LAI; | 2025-05-01 |
| 5 | Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The OVERCOME-TBI project aims to collect multimodal data approximately 1-4 and 11-14 years after an earlier well-documented traumatic brain injury (TBI) and examine factors that influence disease progression in order to gain new scientific insights into the long-term pathophysiology of TBI and identify new therapeutic targets. TBIs are among the most serious health problems worldwide and represents a significant burden for the injured, … |
JUSSI P. POSTI; | 2025-05-01 |
| 6 | Effectiveness of Recruitment, Retention Strategies, and Data Collection Quality: A Feasibility Study in Combat Athletes with Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The use of Hyberbaric Oxygen Therapy (HBOT) would be a new treatment plan rather than conventional rest. If effective, this new use technology would add to the clinical treatment among mild traumatic brain injury (mTBI) patients. The use of a point of care Glial Fibrillary Acidic Protein (GFAP) biomarker would aid in clinical decision making to create a new care plan of return to sport among unarmed combat athletes who suffer from mTBI. The innovation would be a new treatment and diagnosis strategy that will protect these athletes from serious long-term sequelae. There are no published randomized controlled studies using HBOT to treat concussed athletes within one week of injury. There are no published studies using GFAP levels to predict post concussive symptoms (PCS). |
MICHAEL HARL; | 2025-05-01 |
| 7 | Using High Definition Transcranial Direct Current Stimulation to Treat Verbal Retrieval Deficits Secondary to Chronic Traumatic Brain Injury (STIM-CTBI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI). The type of brain stimulation used is called transcranial direct current stimulation (tDCS). tDCS delivers low levels of electric current to the brain and high definition tDCS (HD-tDCS) delivers the current with multiple electrodes on the scalp. This current is delivered with HD-tDCS to parts of the brain that may help with remembering things. The investigators hope that this can help to improve word finding and memory problems in people with TBI. |
HSUEH-SHENG CHIANG; | 2025-05-01 |
| 8 | Efficacy of Caval Aorta Index for Fluid Optimization in Critically Ill Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury is a leading cause of death and disability in trauma patients. As the primary injury cannot be reversed; management strategies must focus on preventing secondary injury by avoiding hypotension and hypoxia besides, maintaining appropriate cerebral perfusion pressure, which is a surrogate for cerebral blood flow. |
MAHA ABOU-ZEID; | 2025-05-01 |
| 9 | Trifecta Research Study: Examining Hormone Replacement Therapy, Magnetic E-Resonance Therapy, Ibogaine, and 5-MeO-DMT in The Treatment of Posttraumatic Stress Disorder and Traumatic Brain Injury-related Cognitive Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Special Operations Care-Fund (SOC-F) will sponsor the application of four treatments – hormone replacement, magnetic resonance brain stimulation, ibogaine, and 5-Meo-DMT – to Special Operations Forces veterans with a history of combat deployments, traumatic brain injury, and problems with mental health and cognitive functioning. An observational study will be conducted in parallel by the Johns Hopkins Center for Psychedelic and Consciousness Research to determine the effectiveness and safety of each treatment, primarily through measuring post-treatment changes in PTSD symptoms and cognitive functioning. |
SANDEEP NAYAK; | 2025-05-01 |
| 10 | A Randomized Double Blinded Controlled Trial for The Treatment of Persistent Post-concussion Symptoms With Psilocybin Assisted Therapy: A Safety and Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to evaluate the safety, feasibility, and efficacy of psilocybin assisted therapy as an intervention to reduce symptom burden in adult patients (aged 18-65) with persistent post-concussion symptoms (PPCS). This trail will test the following 2 aims: AIM 1 : To test the safety and feasibility of an active psilocybin-assisted psychotherapy to an active control for patients with PPCS AIM 2: To evaluate the efficacy of an active psilocybin-assisted psychotherapy compared to an active control as a treatment for PPCS Participants will be asked to: * Complete a 2 part screening process * Attend a baseline assessment * Complete a psychoeducation preparation session(s) * Attend psilocybin administration session (receive high dose \[25mg\] or low dose psilocybin \[1mg\]) * Complete 5-6 weekly sessions of Acceptance and commitment therapy (ACT) * Repeat outcome measures at 1-week, 4 weeks, 3 months, and 6 months post-psilocybin administration (online only at 6 months). |
CHANTEL T DEBERT; | 2025-05-01 |
| 11 | The Effects of Concussion on Gait and Posture in Individuals with Peripheral Vision Loss PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Changes in gait and balance often occur in individuals who have suffered a concussion. In addition, a subset of concussed individuals also experience peripheral vision loss. To date, changes in gait and balance have not been examined in individuals who have suffered a concussion and also experience peripheral vision loss. |
GREGORY ROBERT; | 2025-05-01 |
| 12 | Safety and Efficacy of Thalamic Focused Ultrasound Stimulation (tFUS) for Promoting Recovery After Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a therapeutic to promote recovery in patients with prolonged DoC as compared to sham treatment, (2) establish dose-related safety and efficacy of tFUS as a therapeutic intervention in prolonged DoC patients and (3) explore preliminary predictors and biomarkers of susceptibility and response to thalamic sonication. |
MARTIN M MONTI; | 2025-04-26 |
| 13 | Reduction of Edema With A Specialized Cocktail for Ultra-early Management in Intracerebral Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability rates, often worsened by perihematomal edema (PHE), which increases intracranial pressure and leads to poor outcomes. Preclinical studies suggest that a pharmacological cocktail (PPA) may help reduce cerebral edema by modulating potassium balance, preserving aquaporin-4 expression, and enhancing lymphatic drainage. This multicenter, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-04-20 |
| 14 | Multi-institutional Phase 2/3 Trial of Fresh Frozen Plasma (FFP) in Patients With Moderate to Severe Traumatic Brain Injury (TBI) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about treatment with fresh frozen plasma (FFP) in individuals with moderate to severe traumatic brain injury. The two main question\[s\]it aims to answer are: * Is the FFP treatment safe? * Does the FFP treatment impact the 24-hour, 3-month and 6-month outcomes, intensive-care free days, mortality, … |
HASAN ALAM; | 2025-04-15 |
| 15 | Reduction of Edema With A Specialized Cocktail for Ultra-early Management in Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Large ischemic stroke is a severe subtype of acute ischemic stroke (AIS), often leading to malignant cerebral edema, elevated intracranial pressure, and poor functional outcomes. Despite early aggressive treatment, malignant cerebral edema remains a major determinant of prognosis, even in cases of successful recanalization. Preclinical studies suggest that a pharmacological cocktail (PPA) may alleviate cerebral edema by modulating extracellular potassium balance, maintaining aquaporin-4 expression, and enhancing lymphatic drainage. This multicenter, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-04-12 |
| 16 | PRophylaxis Against Early VENTilator-associated Infections to Reduce Mortality in Mechanically Ventilated Intensive Care Unit (ICU) Patients With Acute Brain Injuries: A Phase 3 Randomised, Double Blind, Parallel Group, Placebo-controlled Two-side Superiority Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when they have been admitted to hospital with an acute severe brain injury. An acute severe brain injury can occur as a result of a stroke, a traumatic injury or due to lack of oxygen to the brain that happens as a result of a cardiac arrest. Patients who are unconscious after an acute severe brain injury often need assistance to breath adequately, … |
ANDREW UDY; | 2025-04-01 |
| 17 | Behavioral Treatment of Insomnia in Active-Duty Service Members With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to conduct a randomized controlled trial of Cognitive Behavioral Therapy for Insomnia (CBT-I) in a sample of active-duty sailors with a history of traumatic brain injury (TBI). The investigators will test the impact of CBT-I on insomnia symptoms as well as post-concussive symptoms, psychological symptoms, and neurocognitive functioning in comparison to treatment as usual. The investigators will also compare the effectiveness of traditional in-person CBT-I and CBT-I delivered via a clinician-supervised digital health platform, Clinician Operated Assistive Sleep Technology (COAST) in comparison to treatment as usual on symptoms of insomnia, post-concussive symptoms, neurocognitive functioning, … |
ANNE GERMAIN; | 2025-04-01 |
| 18 | Prevalence of Neurodevelopmental Disorders in A Homeless Population – Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction \& Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder). Methods / approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, … |
CAROLINE DEMILY; | 2025-04-01 |
| 19 | Shared Subcortical Arousal Systems Across Perceptual Modalities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a multi-site study and will be conducted at up to 11 investigative sites in the United States. The study will investigate subcortical arousal circuits in visual perception using techniques with complementary strengths based on promising initial studies. |
HAL BLUMENFELD; | 2025-04-01 |
| 20 | Early Neuromodulation for Cognitive Recovery and Rehabilitation in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The two goals of the proposed study are: (1) To determine how brain activity changes with cognitive recovery over time from acute to chronic phases of traumatic brain injury (TBI). (2) To determine how the time of anodal transcranial electrical stimulation (A-tES) administration affects cognitive performance and brain activity in TBI. To achieve these study goals, the investigators will conduct a pilot clinical trial over three years in which the investigators aim to recruit 60 patients with moderate to severe TBI at the University of Cincinnati Medical Center (UCMC). During the acute phase of TBI, … |
ISHITA BASU; | 2025-04-01 |
| 21 | Transcutaneous Spinal Stimulation and Gait Training to Improve Mobility and Motor Control in Individuals with Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to assess the effects of receiving transcutaneous spinal stimulation while performing walking exercises compared to completing walking exercises without spinal stimulation for individuals with hemiplegic TBI. |
KAREN J. NOLAN; | 2025-04-01 |
| 22 | Use of Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness: A Pilot Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prolonged disorders of consciousness (pDOC) are defined as DOC lasting \>1 year post injury for patients with Traumatic Brain Injury (TBI) and \>3 months post injury for patients with non-TBI and at present there are limited treatments that reliably lead to enhanced prognosis. The rehabilitation process throughout the continuum of care for patients with pDOC necessitates restorative strategies to facilitate arousal and functional recovery and coordinated medical management. Rehabilitation interventions for patients with DOC and pDOC have evolved in the past decade, … |
JENNA MANCUSO; | 2025-04-01 |
| 23 | Automated Robotic TCD in Traumatic Brain Injury (ART-TBI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study’s objective is to determine the safety, feasibility and efficacy of prolonged automated robotic TCD monitoring in critically ill patients with severe TBI across multiple clinical sites with varying levels of TCD availability and experience |
VIRGINIA COMMONWEALTH UNIVERSITY | 2025-03-30 |
| 24 | Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) causes acute deficits in cerebral perfusion which may lead to secondary injury and worse outcomes. Inhaled nitric oxide (iNO) is a vasodilator that increases cerebral blood flow and is clinically used for hypoxic respiratory failure in neonates and adults. The investigators will perform a randomized controlled trial of iNO treatment in TBI patients acutely after injury. The investigators will then assess perfusion changes with optic neuromonitoring, blood biomarkers, and 6 month clinical outcomes. |
SAMUEL SHIN; | 2025-03-24 |
| 25 | The Value of Combined Detection of Different Blood Biomarkers in The Diagnosis and Treatments of Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: TBI, as a potential risk factor, causes a 1.5 times higher risk of neurodegenerative disease to up to 30-70% of TBI patients with neurological symptoms. Brain trauma is an important global medical, public health and social problem. Early diagnosis and effective treatment can effectively reduce the disability rate of patients and the incidence of neurological sequelae, and has increasingly become the focus of the international scientific research community. Exploring blood-based biomarkers has potential clinical value, which can greatly help clinicians to evaluate patients’ conditions and develop reasonable plans, … |
FIRST AFFILIATED HOSPITAL XI’AN JIAOTONG UNIVERSITY | 2025-03-15 |
| 26 | Effects of Cerebrolysin on Language Ability in Non-fluent Aphasia Patients After Stroke: A Randomized, Placebo-controlled, Double-blinded, Single Center Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to measure changes in language ability after adding cerebrolysin to standard treatment for non-fluent aphasia patients with post-stroke language impairment. The patients are divided into two groups: the experimental group, which receives a combination of standard treatment (speech therapy) and cerebrolysin, and the control group, which only receives standard treatment (speech therapy). By comparing the PK-WAB scores before and after drug administration, the study seeks to analyze the impact of cerebrolysin on language improvement. According to various stroke registries, … |
YONSEI UNIVERSITY | 2025-03-12 |
| 27 | The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter The Gut Microbiome and Neurologic Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the microbiome leading to changes in fatigue and cognition. |
RANDALL URBAN; | 2025-03-06 |
| 28 | A Confirmatory Study of The Simplified Chinese Version of The Loewenston Occupational Therapy Cognitive Assessment (LOTCA) Battery (2nd Edition) to Assess Cognitive Impairment in Patients with Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, 300 patients aged ≥18 years old with traumatic brain injury (case group) and hospitalized patients without central nervous system disease or their family members and accompanying staff (control group) were selected as the study objects. At baseline, participants completed the Mini-mental State Examination (MMSE), the Loewenston Occupational Therapy Cognitive Assessment (LOTCA) battery, the Glasgow Coma Scale (GCS), and the Alzheimer’s Disease Rating Scale Cognitive Subscale (ADAS-Cog11). The evaluation process of the first LOTCA test was videotaped by a person. 2 weeks after the evaluation, … |
TONG RU YU; | 2025-03-01 |
| 29 | CRANIUM: Post-Market Performance Follow-up Study for The Evaluation of The Presence of Circulating Plasma Brain Biomarkers in Peripheral Blood and Acute Traumatic Brain Injury in Adult Emergency Department Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Each year, approximately 69 million people worldwide suffer from traumatic brain injuries (TBI), representing a significant burden on public health, society, and the economy. Timely and accurate care can influence short-, medium-, and long-term outcomes, making the reduction of diagnostic delays crucial. TBI diagnostics require careful consideration, as initial evaluations may differ from final assessments, and patient conditions may evolve over time. In this monocentric, observational, … |
JODY FILIPPO CAPITANIO; | 2025-03-01 |
| 30 | Effects of An AI-driven Personalized Exercise Feedback Program on Exercise Adherence and Health Outcomes in Patients with Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to develop and evaluate an AI-driven Personalized Exercise Feedback Program (AI-PEF) to enhance exercise adherence and health outcomes in mTBI patients. Methods: AI-PEF integrates the transtheoretical model and self-determination theory with machine learning algorithms to provide real-time, personalized feedback. A phased randomized controlled trial will be conducted: Phase I evaluates feasibility and acceptability through Delphi methods with expert consensus and patient feedback; Phase II validates preliminary outcomes with 30 participants in a 2-arm randomized trial; and Phase III assesses the program’s impact on adherence, sleep quality, depressive symptoms, … |
HUI-HSUN CHIANG; | 2025-03-01 |
| 31 | HIT HEADS 2.0: Head Injury Treatment: A Randomized, Placebo-controlled, Double-blinded, Therapeutic Clinical Trial of Branched Chain Amino Acids (BCAAs) in The Treatment of Concussion PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion. The aim of the study is to determine whether administration of high-dose BCAAs compared to placebo promotes concussion recovery. |
DANIEL CORWIN; | 2025-03-01 |
| 32 | Effect of Volatile-based Versus Total Intravenous Anesthesia on Cerebral Homeostasis and Neucognitive Function in Patients Undergoing Elective Craniotomy for Brain Tumor Excision PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The brain is a metabolic active organ with constant energy demands. Brain oxygen supply is secured via cerebral circulation. Brain tumor surgery is commonly associated with the tumor’s underlying pathophysiology including brain swelling or edema. During craniotomy for brain tumor resection maintenance of cerebral hemodynamic stability is of paramount importance. Neuroinflammation is also a normal response to trauma, … |
GEORGIA TSAOUSI; | 2025-03-01 |
| 33 | Can A High Intensity Exercise Program for People With Neurologic Disabilities Run By Doctoral of Physical Therapy Students Improve Mobility in Everyday Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Hawks in Motion (HIM) High Intensity Exercise program is designed to implement the American Physical Therapy Clinical Practice Guidelines and American College of Sports Medicine recommendations for exercise for people with neurologic disability. Doctor of Physical Therapy (DPT) students administer the HIM High Intensity Exercise Program. A prior study evaluated the feasibility, safety, and efficacy of the HIM High Intensity Exercise Program and found it feasible, safe, … |
MARY GANNOTTI; | 2025-02-24 |
| 34 | An Assessment of Clinical Efficacy of Hypothermic Therapy Following Mild Traumatic Brain Injury (mTBI) in The Adolescent Athlete As Compared to An Untreated Active Control Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being conducted to quantify the clinical safety and efficacy of head and neck cooling, using the Pro-2-Cool device, when applied after mTBI injury sustained by adolescents aged 12-21 years, participating in sporting activities. |
BRIAN REILLY; | 2025-02-20 |
| 35 | Hypertonic Lactate After Cardiac Arrest PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is intended to test the hypothesis that sodium lactate infusion after resuscitation from a cardiac arrest will decrease the magnitude of brain damage, as measured by the serum biomarker concentration of NSE. |
FILIPPO ANNONI; | 2025-02-19 |
| 36 | Evaluating A Novel Method to Determine The RTMS Dose Needed for Treating Depression After Spinal Cord Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Depression is a leading cause of disability worldwide and is more commonly seen in individual’s post-spinal cord injury (SCI) than in the general population. Depression post-SCI impacts an individuals’ quality of life and recovery. It has been reported that among Veterans with an SCI, those without depression live longer than those with depression. Thus, depression must be treated appropriately. Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression, but dosing is based on a motor response or movement in the thumb. Over half of individuals with SCI have some degree of arm or hand impairment, … |
CATHERINE J VANDERWERKER; | 2025-02-07 |
| 37 | Evaluation of The Abbott I-STAT TBI Biomarker Test for Effect on Decreasing CT Utilization Among Adult Emergency Department Patients With Suspected Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: According to the Centers for Disease Control and Prevention, approximately 200,000 hospitalizations occurred in 2020 related to Traumatic Brain Injury (TBI), which does not include many TBIs treated only in emergency departments, urgent care, primary care, or that are not evaluated by a clinician. Head CT is a critical component of care for severe TBI, however in mild TBI there is practice variation with a wider risk to benefit estimation for obtaining head CT imaging. Potential disadvantages of head CT include longer Emergency Department (ED) length of stay (LOS), higher costs, … |
SHAMEEKE TAYLOR; | 2025-01-30 |
| 38 | Capturing Autobiographical Memory Formation in People Moving Through Real-World Spaces Using Synchronized Wearables and Intracranial Recordings of EEG PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main questions it aims to answer are: How does the brain encode and retrieve real-world autobiographical memories? Can multimodal data integration enhance our understanding of memory-related cognitive and neural mechanisms? Participants will: * Use a smartphone-based recording application (CAPTURE app) to collect real-world data. * Have their wearable sensor data (e.g., audio-visual, accelerometry, GPS, autonomic physiology, … |
CORY INMAN; | 2025-01-30 |
| 39 | Evaluating The Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Propranolol primarily acts as a non-selective beta blocker, blocking both beta-1 and beta-2 adrenergic receptors, while carvedilol exhibits a broader spectrum of action by also blocking alpha-1 adrenergic receptors. The receptor blockade profile of a beta blocker can influence its physiological effects and potential therapeutic benefits in TBI. Therefore, the variation in receptor selectivity may result in differences in their impact on secondary brain injury processes and patient outcomes. |
NOHA MANSOUR; | 2025-01-20 |
| 40 | Clinical and Epidemiological Evaluation of Patients Affected By Traumatic and Hypoxic-ischemic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: According to the World Health Organization, perinatal asphyxia is the leading cause of severe neurological disabilities and the second leading cause of neonatal death among term infants, with an incidence of 3.94-5.12 per 1,000 live births. Perinatal asphyxia leads to neonatal hypoxic-ischemic encephalopathy, which remains a common cause of neonatal death and long-term disabilities, affecting 1.5-3 per 1,000 live births in developed countries and up to 26 per 1,000 live births in developing countries. This condition is characterized by altered levels of consciousness or manifests with seizures, often associated with difficulties in initiating and maintaining breathing, … |
ANTONIO CHIARETTI; | 2025-01-15 |
| 41 | Stimulating After Recovery From Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and decision-making. |
DAVID DARROW; | 2025-01-15 |
| 42 | Prospective Ocular Imaging for Intracranial Pressure Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospectively recruiting, database development study collecting images and videos of the spontaneous venous pulsation at the back of people’s eyes – this is a pulse one can see on examination of the back of the eye, originating from the blood vessels around the nerve that connects the eye to the brain (the optic nerve), and is present in most people who have normal pressure around the brain. However, in people with raised pressure in the brain, this pulse disappears as the pressure rises. Many things can cause the pressure around the brain to increase, including tumours, … |
KING’S COLLEGE HOSPITAL NHS TRUST | 2025-01-10 |
| 43 | Safety and Efficacy of Botulinum Toxin A in Patients With Posttraumatic Headache: A Double-blind, Randomized, Placebo-controlled, Parallel-group Trial and Investigation of Neuroinflammatory Biomarkers As Predictors of Efficacy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is an investigator-initiated randomized, placebo-controlled, double-blind, parallelgroup trial. Eighty subjects with PTH will be included and randomized 1:1 for treatment with BTX-A or placebo (isotonic saline). The study comprises a 4-week baseline phase before injection of either active drug or placebo followed by a 12-week evaluation period. Treatment will be double-blind, and subjects will only receive one treatment cycle. Endpoints will be assessed in the evaluation period (weeks 5 to 8) compared to baseline (weeks -4 to -1). |
HENRIK SCHYTZ; | 2025-01-10 |
| 44 | Can Somatic Tracking Help People Living with Tinnitus? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We are examining the effect of mindfulness meditation on attitudes towards tinnitus, as well as physical and psychological distress associated with the condition. The meditation is designed to promote neuroplasticity, fostering new neural connections to help you reinterpret tinnitus through a lens of safety and reduce the perception of threat. This approach integrates several techniques from various psychological therapies which have been promising in reducing tinnitusrelated distress. Therefore, the purpose of this study is to see whether a guided mindfulness meditation intervention is effective in improving the acceptance of tinnitus symptoms, … |
FLORIAN VOGT; | 2024-12-11 |
| 45 | Testing The Efficacy of A Memory Training Program to Improve New Learning and Memory in Portuguese Patients With Multiple Sclerosis: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Deficits in memory and learning are common in Multiple Sclerosis, posing significant challenges in patients’ daily lives. Cognitive rehabilitation has been shown to be effective in ameliorating these deficits, with programs such as the Modified Story Memory Technique (mSMT). In Portugal, no studies tested the efficacy of memory training programs. We aim to fill that gap by translating and developing mSMT, conducting a randomized double-blind, placebo-control, clinical trial, and, therefore, testing its efficacy through objective measures of cognitive function, … |
MÁRCIA INÊS TEIXEIRA FRANÇA; | 2024-12-05 |
| 46 | 3D Transcranial Ultrasound Brain Imaging (3D-TRUBI) Instrument for Point-of-Care Diagnosis of Intracranial Hemorrhages Caused By Traumatic Brain Injuries PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to assess the safety of the 3D Transcranial Ultrasound Brain Imaging (3D TRUBI) device in Traumatic Brain Injury (TBI) patients with intracranial hemorrhage (ICH). The secondary objective is to assess the diagnostic potential of 3D TRUBI. The latter will be achieved by comparison of 3D TRUBI scans with admission head computed tomography (CT), … |
THE GENEVA FOUNDATION | 2024-12-04 |
| 47 | Using High Definition Transcranial Direct Current Stimulation to Treat Verbal Retrieval Deficits Secondary to Chronic Traumatic Brain Injury (HDtDCS-CTBI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will improve verbal retrieval in civilian (non-military, non-veteran) participants with histories of traumatic brain injuries. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition, concussion history, structural brain imaging, and EEG predict responses to treatment over time, … |
JOHN HART; | 2024-12-01 |
| 48 | Prismatic Adaptation for Cognitive Rehabiliation in Traumatic Brain Injury Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to evaluate the effects of prismatic adaptation and then of a novel rehabilitation protocol that combines PA and Serious Games on cognitive and behavioural deficits in patients with traumatic brain injury , compared to a rehabilitation training without prismatic adaptation. Moreover, … |
SIMONA SPACCAVENTO; | 2024-11-07 |
| 49 | Incidence, Characteristics and Evolution of Cerebral Vasospasm with Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated By Subarachnoid Hemorrhage At Martinique University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for 30% of deaths by trauma. It is complicated in 30-60% of cases by subarachnoid hemorrhage (SAH), which makes it the leading cause of SAH. SAH and its complications are well described when the origin is aneurysmal, … |
MARIE SABIA; | 2024-11-06 |
| 50 | Fluid Dynamics of Concussion in Mixed Martial Arts in A Pilot Randomized Controlled Trial of Osteopathic Manipulative Medicine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose is to test how osteopathic medicine (OMM) improves recovery after a hit to the head during Mixed Martials Arts (MMA). The small changes in the bone, joints, … |
JAYME MANCINI; | 2024-11-01 |
| 51 | Deep Brain Stimulation (DBS) for The Treatment of Cognitive Deficits After Traumatic Brain Injury (TBI): Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with memory and cognitive deficits following TBI that do not respond to conventional treatments experience a decrease in quality of life. Despite advances in neuroimaging, genetics, pharmacology and psychosocial interventions in the last half century, little progress has been made in altering the natural history of the condition or its outcome. This study would explore whether a surgical therapy is safe and potentially effective in patients who develop refractory memory and cognitive deficits following TBI. Preclinical studies suggest that DBS may improve memory deficits in TBI models. Moreover, … |
NIR LIPSMAN; | 2024-11-01 |
| 52 | A Randomized Controlled Trial Investigating The Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective double blind phase II study seeks to evaluate the safety and efficacy of BRC-003, a high CBD investigational product, in the treatment of refractory PTE (Post-Traumatic Epilepsy). The research is divided into two phases: an open-label dose-finding phase (Part A) and a subsequent randomized controlled phase (Part B). This design aims to provide a thorough understanding of the investigational product’s impact on seizure frequency, seizure severity, mood, anxiety, sleep, and quality of life. |
PAUL LYONS; | 2024-11-01 |
| 53 | Uncovering The Acute Neurobiological Significance of Emerging Sexual Behaviors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the acute effect of being choked during partnered sex on neurological measures. The study is designed to identify the effects being choked during partnered sex on the brain through the use of neural-injury blood biomarkers, functional, diffusion, and perfusion MRI, and ocular-motor function across 3 time points (baseline, post-choking, post-non-choking). The central hypothesis is that acute neuronal structural, physiological, and functional alterations will be amplified after an incidence of choking-involved sex. The neural-injury blood biomarkers neurofilament light (NfL), glial fibrillary acidic protein (GFAP), Ubiquitin C-Terminal Hydrolase L1 (UCH-L1), … |
KEISUKE KAWATA; | 2024-09-25 |
| 54 | Ketamine for Sedation in Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This protocol is for an open-label randomized trial evaluating the safety of using ketamine in combination with propofol for sedation versus the standard of care analgosedation in patients admitted to the intensive care unit with severe traumatic brain injury. |
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE | 2024-09-23 |
| 55 | CONSTRAINT-INDUCED MOVEMENT THERAPY (CIMT) VS. MIRROR THERAPY (MT) ON HAND FUNCTION AND SPASTICITY IN PATIENTS WITH HEMIPARESIS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to compare the effects of Constraint-Induced Movement Therapy (CIMT) and Mirror Therapy (MT) on hand function and spasticity in individuals with hemiparesis. A total of 68 participants diagnosed with hemiparesis due to stroke or traumatic brain injury were recruited and randomly assigned to two equal groups. Group A received CIMT, … |
MAHNOOR ALEEM; | 2024-09-15 |
| 56 | Effects of Prolonged and Chronic Critical Illness Induced By Brain Injury on Metabolic State: Matched Case-control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Brain injuries, including acute stroke (AS) and traumatic brain injury (TBI), are prevalent pathologies with severe consequences. Cerebral infarction accounts for 65-85% of AS cases, while hemorrhagic stroke, though less common, has a higher mortality rate (30-50%) and limited recovery (10-20%). TBI is a significant medical and socioeconomic issue due to its high prevalence, severe consequences, and the high rates of temporary and permanent disability, particularly among young and working-age adults. The average mortality rate for severe TBI is 39%, with 60% facing unfavorable outcomes according to the Glasgow Outcome Scale. High levels of permanent disability, … |
ALEXANDER SHESTOPALOV; | 2024-08-15 |
| 57 | Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for The Acute Treatment of Traumatic Brain Injury PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if experimental drug treatment improves recovery after TBI as compared to a control (placebo) group. Changes in recovery will be measured throughout the study. The study drugs listed below are approved by the U.S. Food and Drug Administration (FDA) but are being used off-label in this study. This means that the drugs are not currently approved to treat TBI. |
GEOFFREY MANLEY; | 2024-08-01 |
| 58 | Efficacy of Carotenoids on Blood Biomarkers Following A Collision Sport Athletes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a supplement study being conducted to find out if collision sport athletes who are exposed to repetitive head impacts while supplementing with carotenoids will have decreased pro-inflammatory blood biomarkers, increases in macular pigment optical density, improved contrast sensitivity, greater retinal nerve fiber thickness, and better overall visual quality of life scores compared to collision athletes taking a placebo. |
SEMYON M. SLOBOUNOV; | 2024-08-01 |
| 59 | Wearable Technology to Characterize and Treat MTBI Subtypes: Biofeedback-Based Precision Rehabilitation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Current clinical assessment tools are often not sensitive enough to detect and treat some subtle (yet troubling) problems after mTBI. In this study, the investigators will use wearable sensors to both assess and treat people with mTBI. Specifically, the investigators will provide immediate feedback, with visual and/or auditory, … |
LAURIE KING; | 2024-06-13 |
| 60 | Predictors of Mortality Among Patients With Head Trauma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the usefulness of the APACHE II (Acute Physiology and Chronic Health Evaluation II), RTS (Revised trauma score), GCS (Glasgow Coma Scale) scores and various variables as age, sex, lab.data and complications in predicting mortality of patients with traumatic brain injury (TBI) in the intensive care unit (ICU). |
AYMAN MAHMOUD ALSAYES; | 2024-06-01 |
| 61 | Multicenter, Double-blind, Randomized, Placebo Controlled, Study to Assess The Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301), in Patients with Severe Traumatic Brain Injury (TBI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main goal of this clinical trial is to check if the treatment is safe and well-tolerated. Researchers will compare the MR-301 active drug group with the placebo group to evaluate the safety and tolerability of the drug. Other measurements include assessing the patient’s overall outcome, neurological responses, time spent in the intensive care unit, time in the hospital, and mortality. Participants will receive either MR-301 BID IV dosing or a matching placebo for a total of 3 weeks. |
SHINKEI THERAPEUTICS | 2024-06-01 |
| 62 | Using Functional Near-Infrared Spectroscopy (fNIRS) to Assess Neural Activity During A Virtual Reality Walking Intervention: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and feasibility of using a portable neuroimaging device called functional near-infrared spectroscopy (fNIRS) to successfully analyze fNIRS data in individuals with chronic TBI during treadmill training augmented with VR. |
CANDACE TEFERTILLER; | 2024-05-27 |
| 63 | Real-life Performance and Added Value of The VIDAS® TBI Blood Test in The Assessment of Mild Traumatic Brain Injury (mTBI), in Subjects With A Glascow Coma Scale (GCS) Between 13-15 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Decision Rules for an initial CT-scan in patients arriving to Emergency Department (ED) and presenting a mild traumatic brain injury could be optimized by the use of an objective parameter easily and rapidly measured. This may be the place for serum biomarkers providing a quick and accurate assessment. BioMérieux has now developed an automated assay for the measurement of serum Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase (UCH-L1), the VIDAS® TBI assay to fill out this unmet needs. The goal of the herein study is to generate real-world data and evidences to support the VIDAS® TBI performances. |
LINDA PAPA; | 2024-05-16 |
| 64 | A Randomized Controlled Study to Explore The Efficacy of Stellate Ganglion Block in Traumatic Brain Injury Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this or clinical trial is to explore efficacy of stellate ganglion block on dysphagia and activities of daily living in Traumatic Brain Injury Patients. The main question it aims to answer are: Can stellate ganglion block improve the dysphagia and activities of daily living in Traumatic Brain Injury Patients. Traumatic Brain Injury Patients will be divided into the the control group and observation group evenly. All the patients were provided with routine therapy, while the patients in the observation group were given stellate ganglion block. The swallowing function, … |
COPKA SONPASHAN; | 2024-05-01 |
| 65 | Cisternostomy Vs Decompressive Craniectomy for Severe Traumatic Brain Injury: Functional Outcome Comparison Using Glasgow Outcome Scale PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this clinical study is to compare the outcomes of two neurosurgical interventions, Cisternostomy and Decompressive Craniectomy (DC), for the management of severe Traumatic Brain Injury (TBI), assessed using the Glasgow Outcome Scale (GOS). Severe TBI presents challenges in managing intracranial pressure (ICP) and cerebral perfusion, often requiring surgical intervention. DC involves the removal of a section of the skull to reduce ICP, while Cisternostomy, a technique rooted in microsurgery, aims to alleviate brain edema and lower ICP by creating additional space for cerebrospinal fluid (CSF) circulation. This prospective study will be conducted at the Department of Neurosurgery, … |
MUSTAPHA SHESH; | 2024-05-01 |
| 66 | A Comparative Analysis of Prognostic Factors for Functional Outcomes in Patients With Acute Subdural Hematoma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute subdural hematoma (ASDH) is the most common intracranial traumatic lesion that requires surgical intervention. Although there is extensive published research on acute subdural, there remains uncertainty regarding mortality risk and functional outcomes for patients. This study aims to evaluate the effectiveness of contemporary scoring systems in different age groups of ASDH patients to predict functional outcomes. |
MICHAL SOTÁK; | 2024-05-01 |
| 67 | Added Value, Performance and Acceptance of The GFAP-UCH-L1 Pair in The Evaluation of Subjects with Mild Traumatic Brain Injury (MTBI) At Intermediate Risk of Complications PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate the performance of UCH-L1 and GFAP combined in patients with a mild traumatic brain injury. The main question : • Does the combination of UCH-L1 and GFAP can exclude brain injuries detected with CT scan in the first twelve hours after a mild traumatic brain injury? Participants will do the exams planed in routine care and : * during the expected blood sampling an additional blood sample will be done, * seven days after the discharge a call will be done by the investigator. |
CENTRE HOSPITALIER PRINCESSE GRACE | 2024-04-19 |
| 68 | Promoting Wellness in Individuals With Traumatic Brain Injury: A Randomized Trial Assessing The Effectiveness of The Mindfulness, Exercise, Nutrition to Optimize Resilience (MENTOR) Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized trial aims to determine the effectiveness a virtual wellness intervention program in individuals with traumatic brain injury (TBI). Participants will be randomized at enrollment into two groups: immediate treatment (IT) and delayed treatment (DT) group. This study will also provide insights into the impact of these intervention’s components in helping emotional, physical, and nutritional outcomes post-injury in the context of social determinants of health (SDOH). |
TAMARA BUSHNIK; | 2024-04-11 |
| 69 | Planning, Reminders and Micro-incentives to Increase Walking After Traumatic Brain Injury in Older Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to learn if different behavioral interventions can change walking behaviors over 12-weeks, in older adults who have previously suffered a non-penetrating mild or moderate TBI. Participants will provide information and be screened for eligibility via phone screening call (verification of age, confirmation that the participant is not currently on any medication that affects the central nervous system, and verification that the subject can participate in exercise, brief TBI history). Baseline testing will take place at the Center for Cognitive and Brain Health and Northeastern University Biomedical Imaging Center, for the baseline magnetic resonance imaging, … |
TIMOTHY MORRIS; | 2024-04-10 |
| 70 | Stellate Ganglion Block Combined With Dexmedetomidine or Subanesthetic Ketamine Infusion for Treatment of Neurostorm After Traumatic Brain Injury in Critically Ill Patients: A Randomized Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Neurostorming is a sudden and exaggerated stress response as a result of damage to the brain. With appropriate treatment and time, there is hope for individuals to overcome storming, regain consciousness, and work towards successfully recovering from brain injury. Most treatments for neurostorming involve the use of medications only such as dexmedetomidine, opioids, gabapentin and propofol to address secondary complications like high blood pressure and fever. These medications focus on slowing the body’s stress response or relaxing the body. Stellate ganglion block (SGB) is a promising therapy for paroxysmal sympathetic hyperactivity (PSH), … |
ESLAM S. ALMAGHAWRY MOHAMED; | 2024-04-04 |
| 71 | Development of Ecological Momentary Intervention for Memory in Chronic Traumatic Brain Injury: A Pilot and Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot and feasibility study for a mobile phone-delivered intervention for memory, called MEMI (memory ecological momentary intervention), that was designed to support adults with chronic traumatic brain injury with their memory. The goal of the study is to examine the feasibility and acceptability of MEMI and to assess preliminary efficacy as to whether technology-delivered spaced memory retrieval opportunities improve memory in people with and without a history of chronic traumatic brain injury. |
EMILY MORROW; | 2024-04-03 |
| 72 | Feasibility and Effects of Transcutaneous Auricular Vagus Nerve Stimulation Timings in A Sensorimotor Task PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the feasibility and effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in enhancing sensorimotor learning and adaptation. This study will focus on healthy individuals performing a robotic sensorimotor task. Main Questions it Aims to Answer: How does taVNS, with different timing protocols, affect the feasibility and effectiveness of performing a robotic sensorimotor task? What is the impact of taVNS on sensorimotor learning and adaptation? Participants Will: Be pseudo-randomly assigned to one of five experimental groups with different taVNS stimulation timings. Perform a sensorimotor task multiple times across sessions, … |
OLIVIER LAMBERCY; | 2024-04-01 |
| 73 | Hyperbaric Oxygen Therapy As A Neuroprotective Modality in Pediatric Acquired Brain Injury With Motor Disability PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to assess the efficacy of hyperbaric oxygen therapy as a neuroprotective intervention in children with acquired brain injury. |
EMAN MOHAMMED ABDEL HAMID GAML; | 2024-03-01 |
| 74 | A Randomized Controlled Study to Explore The Effect of Different Feeding in Traumatic Brain Injury Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding or the control group with Nasogastric tube feeding for enteral nutrition support, respectively. Nutritional status, complications, decannulation of tracheostomy tubes and level of consciousness on day 1 and day 28 were recorded and compared. |
COPKA SONPASHAN; | 2024-03-01 |
| 75 | Clinical Trial Evaluating The Effect of Tranexamic Acid on The Clinical Outcomes in Pediatric Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the effect of tranexamic acid on mortality in pediatric patients with traumatic brain injury. This could potentially lead to improved treatment protocols and better outcomes for this vulnerable population. |
NOHA MANSOUR; | 2024-03-01 |
| 76 | Effect of Lidocaine Block in Traumatic Brain Injury: A Double-blind Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this or clinical trial is to explore efficacy of stellate ganglion block on dysphagia and activities of daily living in Traumatic Brain Injury Patients. The main question it aims to answer are: Can stellate ganglion block improve the dysphagia and activities of daily living in Traumatic Brain Injury Patients. Traumatic Brain Injury Patients will be divided into the the control group and observation group evenly. All the patients were provided with routine therapy, while the patients in the observation group were given stellate ganglion block. The swallowing function, … |
MUHAMMAD | 2024-03-01 |
| 77 | Impact of Myofascial Release on Dysphagia in Patients With Traumatic Brain Injury: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore Clinical Effect of Myofascial Release Therapy in Dysphagic Traumatic Brain injured Survivors. The main question it aims to answer is: • Can Myofascial Release Therapy improve swallowing function in Traumatic Brain injured Survivors? Patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given Myofascial Release Therapy. The study lasts 21 days for each patient. Researchers will compare the Functional Oral Intake Scale, Penetration-Aspiration Scale, … |
COPKA SONPASHAN; | 2024-03-01 |
| 78 | Assessing The Efficacy of Alterations in Subcortical-Cortical Functional Connectivity From Transcranial Direct Current Stimulation in Older Children After Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations. We are testing a brain stimulation method along with evaluating objective tools to help record and restore communication among affected brain areas, which will facilitate recovery in youth after mTBI. |
GHAZALA TANVEER SALEEM; | 2024-02-20 |
| 79 | Hypoxemia in The First 24 Hours After Trauma – An Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the occurrence of hypoxemia (an abnormally low concentration of oxygen in the blood) in trauma patients within the first 24 hours of hospital admission following arrival to a trauma center. The main questions the study aims to answer are: – Do trauma patients experience hypoxemia during the initial 24 hours of hospital admission following trauma? – … |
JACOB STEINMETZ; | 2024-02-13 |
| 80 | A Randomized Controlled Study to Explore The Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patient Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding or the control group with Nasogastric tube feeding for enteral nutrition support, respectively. Nutritional status, complications, decannulation of tracheostomy tubes and level of consciousness on day 1 and day 28 were recorded and compared. |
ZENG CHANGHAO; | 2024-02-10 |
| 81 | A Randomized Controlled Study to Explore The Effect of Intermittent Oral Esophageal Tube Feeding in Tracheostomized Patients With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding or the control group with Nasogastric tube feeding for enteral nutrition support, respectively. Nutritional status, complications, decannulation of tracheostomy tubes and level of consciousness on day 1 and day 28 were recorded and compared. |
ZENG CHANGHAO; | 2024-02-01 |
| 82 | Study of The One-year Outcomes of Patients Hospitalized in The Lariboisière Neurosurgery Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cognitive sequelae are common following acquired brain injuries. However, their detection can be challenging, particularly in acute care units such as neurosurgery. Specific screening in acute phase is critical for early detection and proper orientation. The Lariboisière cognitive assessment (Cog-First) is a brief cognitive evaluation conducted on a touch-screen tablet for patients with acquired brain injuries in the acute phase, … |
EMMANUEL MANDONNET; | 2024-02-01 |
| 83 | Predictors of Mortality in Patients With Traumatic Brain Injury in The Tertiary Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary outcome of this study was to identify mortality predictors/risk factors affecting mortality and secondary outcome was to determine the distribution of brain injury types and other parameters according to type of trauma in patients with TBI treated in anesthesia-reanimation tertiary ICU. |
SENAY GOKSU; | 2024-02-01 |
| 84 | A Randomized Controlled Study to Explore Effect of Myofascial Release on Dysphagia in Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore Clinical Effect of Myofascial Release Therapy in Dysphagic Traumatic Brain injured Survivors. The main question it aims to answer is: • Can Myofascial Release Therapy improve swallowing function in Traumatic Brain injured Survivors? Patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given Myofascial Release Therapy. The study lasts 21 days for each patient. Researchers will compare the Functional Oral Intake Scale, Penetration-Aspiration Scale, … |
ZENG CHANGHAO; | 2024-02-01 |
| 85 | A Randomized Controlled Study to Explore The Efficacy of Stellate Ganglion Block in Traumatic Brain Injury Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this or clinical trial is to explore efficacy of stellate ganglion block on dysphagia and activities of daily living in Traumatic Brain Injury Patients. The main question it aims to answer are: Can stellate ganglion block improve the dysphagia and activities of daily living in Traumatic Brain Injury Patients. Traumatic Brain Injury Patients will be divided into the the control group and observation group evenly. All the patients were provided with routine therapy, while the patients in the observation group were given stellate ganglion block. The swallowing function, … |
ZENG CHANGHAO; | 2024-01-30 |
| 86 | Anesthetic Greater Occipital Nerve Blockade in Veterans With Post-Traumatic Headache: Sub-study 1 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each. |
YALE UNIVERSITY | 2024-01-26 |
| 87 | A Multi-center, Early Feasibility Study of Using The Mechanical Tissue Resuscitation™ (MTR™) Therapy System for Removal of Excess Fluid in Subjects Who Have Had A Portion of Their Skull Removed to Expose The Dura/Brain and Require Drainage for Fluid Removal Related Papers Related Patents Related Grants Related Experts View Highlight: A multi-center, early feasibility study of using the Mechanical Tissue Resuscitation™ (MTR™) therapy system for removal of excess fluid in subjects who have had a portion of their skull removed to expose the dura/brain and require drainage for fluid removal. |
RENOVO CONCEPTS | 2024-01-15 |
| 88 | Beyond One Option for The Treatment of Severe Traumatic Brain Injury [BOOTStraP]: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe traumatic brain injury (sTBI) is a public health issue with great disparity among low- and middle-income countries where the implementation of evidence-based guidelines is challenging because resources are often unavailable. A consensus process including experts in the prehospital, emergency department, neurosurgery, and intensive care unit took place in Colombia to develop a set of stratified protocols called BOOTStraP, targeting resource-poor environments, but it has not been systematically implemented and tested. To identify the facilitators of, and barriers to, collecting data about patients with sTBI and to implement a stratified protocol across the treatment phases of prehospital, emergency department, neurosurgery, … |
ANDRES M. RUBIANO; | 2024-01-01 |
| 89 | GetUp&Go: A Randomized Controlled Trial of A Theory-Based Intervention to Enhance Physical Activity in Chronic, Moderate-Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate GetUp\&Go, a program for promoting increased physical activity in individuals at least 6 months post moderate-to-severe traumatic brain injury. GetUp\&Go is a remotely delivered 10-week program that includes one-on-one sessions with a therapist and a mobile health application (RehaBot). The main question is whether participants in the 10-week GetUp\&Go program increase their physical activity, and exhibit associated benefits in mental and physical health, relative to those who are put on a waitlist. * Question 1: Do participants who receive immediate treatment with GetUp\&Go show more increased physical activity, … |
AMANDA RABINOWITZ; | 2023-12-19 |
| 90 | A Parallel Group Treatment, Phase 2A, Double-blind, 3-arm Study to Investigate Safety and Efficacy of ABX-101 Compared With Placebo in Male and Female Participants, Aged 18 to 50 Years, With Moderate-to-severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the clinical improvement measured by the Glasgow Outcome Scale Extended (GOS-E) with ABX-101 compared with Placebo intramuscular injection in participants with moderate to severe TBI. |
ABALONEX | 2023-12-01 |
| 91 | Feasibility of A Motor-cognitive Training Program in Patients With Traumatic Brain Injury During Acute Hospitalization PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to test feasibility of a motor-cognitive training program in patients after mild to severe traumatic brain injury in an acute hospitalization setting. The intervention is a step-based dual-task training, i.e. patients are presented with step patterns that they have to memorize and then execute in the tempo given by a metronome. Researchers will assess the feasibility of the motor-cognitive training regarding acceptance and safety, user evaluation of the training and training performance. |
ELEFTHERIA GIANNOULI; | 2023-11-20 |
| 92 | New Predictive Tool of Awakening in Comatose Patients in The Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers, imaging and classically electrophysiological examinations, (among them auditive evoked potentials or AEP) but none has a sufficient sensitivity/specificity. In a preliminary study, the investigators developed an algorithm from the signal collected with AEP, and generated a probability map to visually classify the participants after the algorithm processing. Participants could be classified either with a good neurological prognosis or with bad neurological prognosis or death. The investigators hypothesize that the PRECOM tool, … |
JOHANNA OZIEL; | 2023-11-15 |
| 93 | Effectiveness of Motor Imagery Techniques in The Management of Acute Lateral Ankle Sprains in Soccer Players PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effects of motor imagery techniques on pain, proprioception, instability and strength in acute lateral ankle sprains in soccer players |
RIPHAH INTERNATIONAL UNIVERSITY | 2023-11-14 |
| 94 | Assessment of The Feasibility of A Systematic Multidimensional Evaluation of The Outcome of Head Injury Patients and Their Families. A Single-center Pilot Cohort With Repeated Longitudinal Follow-up PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective is to assess the feasibility of collecting and implementing a multidimensional evaluation in a sample of patients with a mild to severe traumatic brain injury (TBI) and their relatives, evaluated at 6 months (primary outcome), and at 12 then 18 months post-injury (secondary outcomes). |
NANTES UNIVERSITY HOSPITAL | 2023-11-11 |
| 95 | Neurophysiological Effect of Ketamine in Patients With Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) accounts for approximately 2.5 million visits to emergency departments in the United States each year. After decades of research, management strategies for severe TBI (sTBI) patients are still evolving. Optimizing intracranial pressure (ICP) and cerebral perfusion pressure (CPP) are paramount in the management of these patients and placement of these monitors is the current standard-of-care. However, … |
NOAH JOUETT; | 2023-11-01 |
| 96 | Role of Brain Specific Biomarkers in Hydrocephalus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Normal pressure hydrocephalus (NPH) is a neurodegenerative disease of unclear etiology characterized by a clinical trias named after the neurosurgeon Hakim. It includes cognitive impairment (dementia), gait disturbance, and urinary incontinence. These symptoms, which frequently occur in the elderly population, often overlap with the symptoms of other neurodegenerative diseases, especially Alzheimer’s disease and other (pre)senile dementias. To distinguishing NPH from other dementias is crucial in determining whether a patient will benefit from a surgical procedure (ventriculoperitoneal shunt placement) or not. At the same time, … |
MIROSLAV CIHLO; | 2023-11-01 |
| 97 | The Effect of Mannitol Volume Administration with Changes in Osmolarity in Traumatic Brain Injury: An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational study is designed to research the effect of mannitol volume administration with changes in osmolarity in patients with traumatic brain injury to guide the safe use of mannitol in these patients. |
TAUFIK SAPUTRA; | 2023-11-01 |
| 98 | Clinical Analysis of The Hormone Between Patients With Moderate and Severe Traumatic Brain Injury and Cerebral Hemorrhage PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Our understanding of neurosecretory dysfunction after TBI is still insufficient, and the number of patients with neuroendocrine dysfunction caused by craniocerebral trauma may be underestimated, especially the neuroendocrine changes related to HPA axis in the early stage after craniocerebral trauma. Moreover, there are few and fragmentary literature data on the benefits of hormone replacement therapy in patients with neuroendocrine disorders after traumatic brain injury. This requires more studies to further determine the characteristics of pituitary function or hormone disorders in the early stage after traumatic brain injury, … |
GENERAL HOSPITAL OF NINGXIA MEDICAL UNIVERSITY | 2023-10-01 |
| 99 | Home-based and Mobile App-guided Dual-Task Exercise for Cognition and Functional Capacity After Mild Traumatic Brain Injury (mTBI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators previously developed a virtual 14-day dual-task walking exercise program and tested its feasibility with individuals with mild traumatic brain injury (mTBI) history. The investigators will test the feasibility and efficacy of a mobile app-version (Uplode) of the same 14-day exercise program (Brain & Walk Exercise Every Day [BraW-Day]), on cognition, sensorimotor, and other functions in a group of voluntary young adults with an mTBI between last three months to two years, including student athletes, Veterans, and ethnic minorities. |
HYUNHWA LEE; | 2023-09-15 |
| 100 | Brain Development in Young Children Following Mild Traumatic Brain Injury – Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Concussions (also known as mild traumatic brain injury) are common in young children. In some children, they can lead to short- and long-term difficulties. However, our knowledge of the exact consequences of injuries on young children’s brains and behavior is limited. These consequences may be different in children under 6, as their brains are fragile and undergoing significant developmental changes. The aim of this study is to determine the extent to which a concussion sustained before the age of 6 years is associated with changes in young children’s brain structure, function and behaviours, using a brain imaging. In this study, … |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE FRANCE | 2023-09-02 |
| 101 | Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients With Traumatic Brain Injury Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study will be to measure the predictive power of the respiratory muscle determinants including The maximal inspiratory pressure, and central drive determinant including Airway occlusion pressure and ratio between them in weaning outcome of traumatic brain injury patients undergoing invasive mechanical ventilation. |
ALI RASHAD; | 2023-09-01 |
| 102 | Post-traumatic Headache: Phenotyping and Exploring Pathophysiological Insights and Novel Treatment Strategies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aim of the study is to advance the knowledge on the characterization and underlying pathophysiological mechanisms of persistent post-traumatic headache (PTH) with a direct impact on the ability to diagnose and manage PTH effectively. The investigators also aim to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS), a novel intervention on PTH. |
CHARLOTTE NYGAARD; | 2023-08-28 |
| 103 | Open Label Phase IIa Study Evaluating The Safety and Efficacy of NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to measure changes in cognition through verbal and visual test procedures and changes in biomarkers of Traumatic Brain Injury and inflammatory and metabolic parameters. |
NEUROLOGICAL ASSOCIATES OF WEST LOS ANGELES | 2023-08-21 |
| 104 | Mild Traumatic Brain Injury Identification and Monitoring Through Retional Scanning PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rebion has developed a device, the Rebion trauma tool (referred to as the head and intraocular trauma tool, or HITT), that detects ocular fixation and alignment using a binocular retinal scan. Preliminary data obtained from hospitalized patients with a clinically-confirmed traumatic brain injury (TBI) and uninjured controls indicates that the device can detect changes in ocular fixation, alignment, and saccades that are related to brain injury. This study seeks to evaluate the ability of the Rebion trauma tool to assess perturbations in eye movements resulting from TBI. The study will enroll 60 TBI patients and 20 controls. |
REBISCAN | 2023-08-15 |
| 105 | Survival and Predictive Factors of Clinical Outcome in Patients With Acquired Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The prediction of the final neurological and functional status of patients with acquired brain injury remains very uncertain despite the findings of current medicine. The aim of the study is to evaluate the clinical outcomes in patients with the most severe degree of brain injury hospitalized in the long-term intensive care unit of the Military University Hospital Prague. |
MICHAL SOTÁK; | 2023-08-01 |
| 106 | Pilot Study Protocol of A Randomized Controlled Trial for The Potential Effects of Creatine Monohydrate on Persistent Post-concussive Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Mild traumatic brain injury or concussion is a global public concern, with an estimated annual incidence between 48 million and 96 million worldwide. It is a socioeconomical problem, and almost one-third of individuals with concussion suffer from severe persistent post-concussive symptoms (PPCS), with an increased risk of unemployment or terminating their studies. To date, no single treatment is available with guaranteed success. Creatine monohydrate (CrM) has shown potential as a treatment for post-concussive symptoms, having a positive impact on cognitive function, chronic fatigue, depression, … |
MICHAEL HAURUM MARCUSSEN; | 2023-08-01 |
| 107 | A Prospective, Randomized, Open-label, Two-arms, Multi Center Feasibility Study to Evaluate The Safety and Efficacy of The PlaXtreme Device for Rehabilitation of The Hand in Post-stroke and Post TBI Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Cerebrovascular accident [CVA or commonly known as stroke] and traumatic brain injury (TBI) are common causes of morbidity, and motor impairments. Many stroke and TBI patients encounter severe functional impairments of their arm and/or hand. Recent studies have indicated that robotic training can improve upper limb function by enabling repetitive, adaptive, and intensive training. One type of robotic training is error enhancement during three-dimensional movements. The goal of this approach is to elicit better accuracy, stability, … |
RAMI MANSOUR; | 2023-08-01 |
| 108 | Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: in some patients, a few days or weeks after they recover from carbon monoxide poisoning they develop new symptoms. These can affect mood, ability to think or remember clearly, and movements. Some people develop movement problems that are similar to Parkinson’s disease. This damage to brain tissue is called encephalopathy, and this study will look at the effect of pressurized oxygen therapy on long term, or chronic, encephalopathy. |
JEFFREY COOPER MD FAAEM; | 2023-07-31 |
| 109 | Evaluation of Chemical Venous Thromboembolism Prophylaxis in Trauma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Venous thromboembolism (VTE) causes up to 100,000 deaths annually. Between 10%-30% of patients die within one month of VTE diagnosis, while survivors remain at increased risk for VTE recurrence or other complications like post-thrombotic syndrome or chronic pulmonary hypertension in the following decade. Trauma patients have many risk factors that predispose them to a VTE. During the first 48 hours after blunt trauma, patients are prothrombotic due to the release of procoagulant factors, have excessive thrombin generation due to extensive tissue and vascular injury, and have reduced circulation of endogenous anticoagulants like protein C. |
TAMARA REITER; | 2023-07-21 |
| 110 | Intra-operative Evaluation of The External Ventricular Drain Catheter Position With Structured Light PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The placement of external ventricular drainage (EVD) is a life-saving procedure used to relieve high pressures in the brain. Often performed at the bedside, a small tube (catheter) is inserted into one ventricle of the brain to drain cerebrospinal fluid and release the pressure build up. In standard practice, EVDs are placed freehand and initial catheter malpositioning occurs in up to ~60% of procedures. Currently, there are no adequate means to verify the position of the catheter before insertion which is a significant impediment to ensure accurate positioning. This non-interventional study aims to validate a novel technology, Bullseye EVD, … |
CARI WHYNE; | 2023-07-07 |
| 111 | The Value of Multimodal MR Imaging in Cognitive Assessment of Patients With Moderate Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about in The value of multimodal MR Imaging in cognitive assessment of patients with moderate traumatic brain injury. The main question it aims to answer is: • The construction of the core injury model of cognitive impairment caused by moderate brain trauma takes multi-parameter MR scanning as the main line of research, centering on the analysis of cognitive impairment of white matter structure damage and brain function involved in the research institute, … |
FIRST AFFILIATED HOSPITAL XI’AN JIAOTONG UNIVERSITY | 2023-07-03 |
| 112 | Enhancing Precision Sleep Medicine in Traumatic Brain Injury: Examining The Feasibility of Home-Based Measurement of Circadian Timing PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Veterans with traumatic brain injury (TBI) frequently experience insomnia, which is linked with delayed TBI recovery, more severe functional impairment, and exacerbation of disabling TBI after-effects such as depression, chronic pain, and fatigue. Current research suggests that TBI can impact numerous systems involved in sleep, suggesting that insomnia can have various causes and that a one-size-fits-all approach to treatment is likely inadequate. As such, it is necessary to determine which Veterans may benefit from standard evidence-based treatments, such as Cognitive Behavior Therapy for Insomnia, … |
DANIEL J REIS; | 2023-07-01 |
| 113 | The Narcotrend Depth of Anaesthesia Monitor As An Indicator of Seizures and Burst Suppression in The Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A study in the use of the Narcotrend depth of anaesthesia monitor to record a) seizures, and b) monitor a level of sedation referred to as ‘burst suppression’, in sedated patients in the adult and paediatric intensive care. Studies have shown that patients in coma on the intensive care unit may have subclinical in addition to clinical seizures. Subclinical seizures are seizures that do not show any outward signs and may go undetected. The current gold standard of recording seizures in the intensive care unit is by non-invasive, … |
HELEN SNEATH; | 2023-06-27 |
| 114 | Effect of Enteral Polymeric Formulas (Commercial and Homemade Formula) on Muscle Mass in Adults With Trauma Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled clinical trial aims to determine whether there are differences in muscle mass (MM) in patients with traumatic brain injury who receive enteral nutrition based on polymeric formulas (homemade formula with blended natural foods versus commercial formulas). |
KARINA AGUILAR GUTIERREZ; | 2023-06-26 |
| 115 | A Mixed Methods Study to Assess The Clinical Effectiveness and Acceptability of QER Artificial Intelligence Software to Prioritise CT Head Interpretation PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-Contrast Computed Tomography (NCCT) of the head is the most common imaging method used to assess patients attending the Emergency Department (ED) with a wide range of significant neurological presentations including trauma, stroke, seizure and reduced consciousness. Rapid review of the images supports clinical decision-making including treatment and onward referral. Radiologists, those reporting scans, often have significant backlogs and are unable to prioritise abnormal images of patients with time critical abnormalities. Similarly, identification of normal scans would support patient turnover in ED with significant waits and pressure on resources. To address this problem, … |
DAVID J LOWE; | 2023-06-01 |
| 116 | Concussion and Omega-3s – New Consideration for The Therapeutic Use of Nutritional Supplements in Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test omega-3 fatty acid supplementation as a treatment in adolescents with a concussion. The main questions it aims to answer are: – Does supplementing with omega-3 fatty acids improve time to recovery following sport related concussion. – Does supplementing with omega-3 fatty acids improve health related quality of life following concussion. – Does supplementing with omega-3 fatty acids change post-concussion symptoms following concussion. – Does supplementing with omega-3 fatty acids change saliva concentrations of interleukin-6 following concussion. – … |
STEPHEN CORNISH; | 2023-06-01 |
| 117 | Quality of Life in Traumatic Brain Injury Patients: Assessment at Discharge From An Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to describe the quality of life of CT patients in our study, at least 6 months after the occurrence of the trauma. This assessment is related to the patient’s degree of sequelae, using the GOSE scale. |
HEDI GHARSALLAH; | 2023-06-01 |
| 118 | Neurometabolic Effects of Theta-burst Treatment in Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test a new type of magnetic brain stimulation in patients with persistent post-concussive symptoms. Participants will undergo detailed MRI scans before and after 30 treatment sessions (of 3-10 minutes each). The main questions the study aims to answer are: – Will this new type of treatment result in fewer symptoms and better daily functioning? – What are the effects of this treatment on brain functioning? |
HARM J VAN DER HORN; | 2023-06-01 |
| 119 | Proteomic and Metabolomic Detection and Analysis of Serum From Patients With Acute Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this experimental observation study is to figure out differently expressed biomarkers in serum in traumatic brain injury patients, compared with bone fracture patients. The main questions it aims to answer are: 1. Which proteins and metabolites are differently expressed in TBI patients’ serum? 2. Which proteins or metabolites can serve as the new serum biomarkers for diagnosing TBI? Participants will be treated by routine treatments, and their serum samples will be collected in the emergency room. |
JUNFENG FENG; | 2023-06-01 |
| 120 | Pharmacist-Driven Stress Ulcer Prophylaxis Minimization in The Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pharmacologic stress ulcer prophylaxis is routinely used in the intensive care unit (ICU) to prevent upper gastrointestinal (GI) bleeding in critically ill patients. |
HEIDI MICHAELS; | 2023-05-13 |
| 121 | A Pragmatic Rehabilitation Intervention to Supplement Progressive Return to Activity Following Mild Traumatic Brain Injury in Service Members (SMs): The Active Rehab Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The strategic objective of this research line is to examine improving short- and long-term outcomes for soldiers following mild traumatic brain injury (mTBI). The technical objectives are to: 1) conduct a Phase 1 quasi-experimental pragmatic trial testing the potential benefit of provider directed active rehabilitation therapies (Active Rehab) in accelerating return of injured soldiers back to active duty and improving cognitive and functional limitations following mTBI, … |
JOHNA K REGISTER-MIHALIK; | 2023-05-01 |
| 122 | Tele-Rehabilitation to Improve Mild Traumatic Brain Injury Recovery and Reduce Subsequent Injury Risk PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the feasibility, utility, and efficacy of a smartphone-based assessment battery and remotely administered virtual Neuromuscular/Dual-Task (vNDT) intervention among healthy U.S. military service members and physically active young adults with a recent concussion. |
UNIVERSITY OF COLORADO DENVER | 2023-04-01 |
| 123 | Multiomic Analysis of Traumatic Brain Injury and Hypertension Intracranial Hemorrhage Lesion Tissue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients. The main questions it aims to answer is: – Which RNA, protein and metabolites are differently expressed in lesion tissues? – What molecular mechanism is participated in TBI or ICH? Participants will be treated by emergency operation, and their lesion tissues will be collected during the operation. |
JUNFENG FENG; | 2023-04-01 |
| 124 | Multiomic Analysis of Body Fluid in Acute Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this experimental observation study is to figure out differently expressed biomarkers in body fluid in traumatic brain injury patients. The main questions it aims to answer is: – Which RNA, protein and metabolites are differently expressed in lesion tissues? – What molecular mechanism is participated in TBI? Participants will be treated by emergency operation, and their body fluid samples will be collected in emergency room and during the operation. |
JUNFENG FENG; | 2023-04-01 |
| 125 | TeleRehab to Restore Upper Limb Function in People With Chronic TBI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to inform the subsequent large-scale clinical trial focused on using telerehabilitation techniques and technologies to improve upper limb function and quality of life. |
PEII CHEN; | 2023-04-01 |
| 126 | Pilot Trial of A Web/Mobile/Tablet-based Communication and Goals-of-Care Decision Aid for Clinicians and Families of Severe Acute Brain Injury Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal is to pilot test a highly accessible, web-based, pragmatic, scalable intervention to overcome ongoing problems with high stakes decision-making by surrogate decision-makers of patients in ICUs with severe acute brain injury (SABI), including those with moderate-severe traumatic brain injury, large hemispheric acute ischemic stroke and intracerebral hemorrhage. |
NILS HENNINGER; | 2023-03-28 |
| 127 | Response of Intracranial Pressure Based on Head-of-Bed Positioning in Aneurysmal Subarachnoid Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate how pressure inside the skull responds to position changes in patients with brain bleeds. |
SPRAGUE W HAZARD III; | 2023-03-27 |
| 128 | Improving Balance and Mobility After Traumatic Brain Injury: A Randomized Controlled Trial Evaluating High Intensity Step Training PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will explore whether the types and intensity of the interventions being delivered will yield measurable cognitive benefits in addition to improved mobility and balance. The study evaluates three therapeutic approaches to improve mobility and balance after traumatic brain injury (TBI): Conventional Gait and Balance Training, high intensity step training, and high intensity step training with virtual reality. |
CANDY TEFERTILLER; | 2023-03-20 |
| 129 | Characteristics of Patients With Traumatic Cardiac Arrest in Denmark Assessed By The Danish Helicopter Emergency Medical Services PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates patients suffering from traumatic cardiac arrest assessed by the Danish HEMS between 2016 and 2021. The primary outcome is 30-day survival; secondary outcomes are status at admission to the hospital and prehospital return of spontaneous circulation. Further, the prehospital critical care was identified and evaluated. |
SIGNE AMALIE WOLTHERS; | 2023-03-05 |
| 130 | Assistive Soft Skills and Employment Training (ASSET) in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pediatric traumatic brain injury (TBI) is often associated with difficulties in social functioning. Loss of social contacts and difficulties maintaining social connections is common after pediatric TBI, extending into adulthood. Social skills are a key aspect of social functioning critical to forming and maintaining social relationships with others, including family, friends, … |
JEANNIE LENGENFELDER; | 2023-03-01 |
| 131 | A Study on The Effects of Exoskeleton Robot Walking Training on Adolescents With Cerebral Palsy: A Preliminary Study Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to investigate the effects of exoskeleton robot gait training on activities of daily living, gross motor function evaluation, balance and walking ability in adolescents with cerebral palsy. |
YEONGYU JEONG; | 2023-03-01 |
| 132 | Building Emotional Self-Awareness Teletherapy (BEST): A Tool to Optimize Psychological Health Outcomes for Persons with Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine the feasibility, acceptability, and preliminary efficacy of a remotely delivered intervention for civilians and service members with mild traumatic brain injury (mTBI) who have difficulty recognizing and regulating their emotions. Post-treatment outcomes of interest include emotional self-awareness and regulation, resiliency, and affective symptoms. |
FLORA HAMMOND; | 2023-02-23 |
| 133 | Imaging Characterization of The Biomechanical Coupling of Brain and Skull: An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Traumatic brain injury (TBI) affects over 1.7 million people in the United States each year. Many cases are mild, but people with a history of TBI may have long-term symptoms; … |
JOHN A BUTMAN; | 2023-02-21 |
| 134 | Investigation of The Effect of Assigning Verbal Component Score to Glasgow Coma Scale in Patients With Traumatic Brain Injury and Adding Pupil Reaction to Determining Mortality/Morbidity in Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, it is aimed to determine the prognostic value of GCS-P and the GCS-P score, which is formed by assigning a verbal score, in patients with traumatic brain injury, where all parameters can be evaluated. In the model to be created, a new total score will be obtained with Motor score + Eye Response + assigned verbal Score-Pupil score and this score will be compared with GCS and GCS-Pupil score. |
AKİF BULUT; | 2023-02-20 |
| 135 | A Randomized Controlled Trial of Heart Rate Variability Biofeedback Following Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Individuals with mild traumatic brain injury will be randomly assigned to an active heart rate variability biofeedback condition and a sham condition. The investigators will use a randomized pre-post design that will consist of two data collection phases and a 5-week treatment condition. The heart rate variability biofeedback active condition is designed to increase heart rate oscillations (Osc+ condition) consistent with current best practices, while the sham control heart rate variability biofeedback condition is designed to decrease heart rate oscillations (Osc- condition). |
LEAH TALBERT; | 2023-02-15 |
| 136 | Get Going After ConcussIonN Lite (GAIN Lite): A Digital Intervention to Reduce Impairing Post-concussional Mild-to-moderate Symptoms in Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Concussion affects around 25 000 people each year in Denmark. A large research initiative (GAIN 2.0) has been established, and the current study is a part of this initiative. Aims: 1. To develop and test the efficacy of a novel intervention for people with persistent post-concussional mild-to-moderate symptoms: Get going After concussion Lite (GAIN Lite). 2. To increase the knowledge about the target group by investigating the association of physical activity, digital behaviour, and symptom load. Methods: A randomized controlled trial, … |
SEDSEL PEDERSEN; | 2023-02-13 |
| 137 | Symptom-Targeted Rehabilitation for Cognitive Complaints in Long COVID (STAR-C3) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are comparing two different methods for helping adults with Long Coronavirus (COVID) also known as Post-Coronavirus Syndrome or Post-Coronavirus Condition manage everyday cognitive challenges. Cognitive rehabilitation is a type of therapy that helps people who have challenges with everyday thinking because of a brain injury. One of the investigators on this project along with colleagues in the United States (US) have developed a streamlined version of cognitive rehabilitation therapy for mild traumatic brain injury (mTBI) that can be completed in person or virtually and takes place over a 3-week period. The therapy was originally designed for adults with mTBI. The investigators want to know if it can also be used to treat people with cognitive complaints from Long COVID. The investigators will provide education materials only to one group and individual cognitive rehabilitation delivered by a trained Speech Language Pathologist (SLP) or Occupational Therapist (OT) to the other group. The investigators want to find out whether the individual therapy is as feasible and accessible than the usual educational material. What the investigators learn in this study may help treat day-to-day thinking challenges in Long COVID. |
JACKIE BOSCH; | 2023-02-01 |
| 138 | Multi-Nutrient Supplementation As A Therapeutic Intervention in Ischaemic Stroke (MUST-IS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a significant cause of morbidity and disability worldwide. As the population ages, the economic impact of stroke is becoming substantial. In the United Kingdom, the stroke estimated cost is £26 billion a year. A stroke occurs every 5 minutes, … |
OLIVER SPOONER; | 2023-02-01 |
| 139 | Investigating The Relationship Between Intracranial Pressure and Cerebral Blood Flow Using Near-infrared Diffuse Correlation Spectroscopy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We aim to acquire data using DCS on patients who are undergoing invasive ICP and ABP monitoring on ITU as part of their normal treatment. Data will then be correlated to derive various parameters including CBF and BFI. All interventions are entirely non-invasive. |
QUEEN MARY UNIVERSITY OF LONDON | 2023-01-05 |
| 140 | Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate The Effectiveness of Photobiomodulation With Exercise, to Enhance Motor, Cognition and The Quality of Life of Those With Parkinson’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Parkinson’s disease (PD) is a lifelong and progressive disease and is the second most common progressive neurodegenerative disease worldwide. This study will examine whether there are significant differences in motor (e.g., balance and gait) and non-motor (e.g., cognition, mood, smell & sleep ) symptoms and quality of life between the Real (active) at-home photobiomodulation (light therapy) combined with exercise group and the Placebo (sham) at-home photobiomodulation (light therapy) combined with exercise group. Each group (Real & Placebo) will include 30 participants; with moderate PD, ages 55-80. Three outcome measurement sessions will be conducted; … |
ORLA HARES; | 2023-01-02 |
| 141 | Antisecretory Factor During Concomitant and Adjuvant Therapy of Primary Glioblastoma, A Randomised, Prospective and Double Blinded Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomised, double blinded and multiple center , Phase 2 study in patients with newly diagnosed glioblastoma. Participants will receive an egg powder enriched for antisecretory factor (AF), Salovum, or a placebo egg powder daily from 2 days before concomitant radio-chemo therapy or chemotherapy until 14 days after finalisation plus during adjuvant chemotherapy.The primary aims of are overall survival at 6 and 12 months after diagnosis |
PETER SIESJÖ; | 2023-01-01 |
| 142 | Quantitative EEG Neurofeedback As An Add-on Therapy For Attention-deficit Hyperactivity Disorder (ADHD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Attention deficit/hyperactivity disorder (ADHD) is a common neurological disorder in children, mainly manifesting as attention deficit, excessive hyperactivity, and impulsivity. It is a chronic condition that affects millions of children and often continues into adulthood. The prevalence of ADHD in the worldwide is approximately 5%, predominantly occurring in boys, and more than half of patients continue to experience symptoms into adulthood. Children with ADHD have moral disorders and learning difficulties, and these factors will seriously affect their academic achievements and familial and social relationships; thus, treatment is necessary. Currently, the treatment for ADHD is usually pharmacological intervention, such as methylphenidate, … |
MOHAMED EMAD ELDEEN MAHMOUD; | 2023-01-01 |
| 143 | Effectiveness of M-Health Supportive Care Transition Program in Improving Post-Discharged Outcomes Among Traumatic Brain Injury Caregivers: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This intervention study aims to investigate the effects of the m-Health supportive care transition program on response patterns (transition stress and the burden of caregiving) among traumatic brain injury (TBI) caregivers and patients’ readmission rate one month after hospital discharge. Specific objectives: 1. Compare the response patterns (transition stress and the burden of caregiving) of TBI caregivers before and after receiving the program within the group. 2. Compare TBI caregivers’ response patterns (transition stress and the burden of caregiving) between the control and intervention groups. 3. Compare patients’ readmission rates at one month after hospital discharge between the control and intervention groups TBI caregivers are divided into two groups: the intervention group (who receive the transitional care program) and the control group (who receive the standard care program) according to standard operating procedures applicable in the hospital. If there is a comparison group: Researchers will compare [insert groups] to see if [insert effects] |
AMELIA GANEFIANTY; | 2023-01-01 |
| 144 | Symptom-Targeted Rehabilitation for Concussion in Canadian Armed Forces Veterans PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are comparing two methods for helping improve everyday cognitive functioning in Canadian Armed Forces (CAF) veterans who have sustained a mild traumatic brain injury (mTBI). The two methods are 1) providing educational materials (Education Group) and 2) individual cognitive rehabilitation delivered by a trained Occupational Therapist or Speech-Language Pathologist (Therapy Group). The study is a pilot randomized controlled clinical trial (RCT), and will serve as pilot data for a future RCT. |
LYN TURKSTRA; | 2023-01-01 |
| 145 | Treatment of Word Finding Difficulties and Verbal Retrieval Deficits in Civilians Who Sustain A Chronic Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will improve verbal retrieval in civilian (non-military, non-veteran) participants with histories of traumatic brain injuries. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition, concussion history, structural brain imaging, and EEG predict responses to treatment over time, … |
JOHN HART; | 2023-01-01 |
| 146 | Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Poor emotion recognition has been associated with poor quality of interpersonal relationships, loss of employment, behavioral problems, reduced social reintegration, social isolation and even suicide. Deficits in emotion recognition are common in traumatic brain injury (TBI) and in post-traumatic stress disorder (PTSD) but these deficits have not been well studied in Veterans with both mild TBI (mTBI) and PTSD. Currently there are no interventions for emotion recognition in Veterans with mTBI and PTSD, … |
JULIA K. WAID-EBBS; | 2022-12-01 |
| 147 | Neuroprotective Effects of Xenon Treatment in Patients With Cerebral Infarction: Randomized Single-blinded Placebo-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the Russian Federation, ischemic cerebral infarction is recorded annually in more than 450,000 people. It is the second most common cause of death after coronary heart disease. The 30-day mortality rate after an ischemic cerebral infarction is more than 25%, and during the following year about half of the patients die. To date, all candidate neuroprotective drugs tested in various clinical trials have demonstrated insufficient efficacy . Therefore, … |
OLEG A. GREBENCHIKOV; | 2022-12-01 |
| 148 | Reviving Hope: Rehabilitation of Traumatic Brain Injury: Nursing Approaches for Arousal Enhancement PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury is a leading cause of long-term disability, necessitating innovative rehabilitation methods. This study evaluates the effectiveness of integrating nursing techniques with arousal enhancement protocol to promote neurological recovery in traumatic brain injury patients. |
MOHAMMED ELSAYED ZAKY; | 2022-11-12 |
| 149 | Assessment of Temporomandibular Joint Dysfunction in Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Trauma, neurological disorders and psychological problems, which are the etiological factors of temporomandibular joint dysfunction, can be seen in patients with traumatic brain injury. The aim of this study is to investigate temporomandibular joint dysfunction in patients with traumatic brain injury. Participants (traumatic brain injury patients and healthy volunteers) will be evaluated once for temporomandibular joint dysfunction. |
SAVAŞ KARPUZ; | 2022-11-05 |
| 150 | Predictors of Brain Death and Barriers to Organ Donation in A North African Intensive Care Units: A Multicenter Prospective Study on Severe Coma Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study was to identify factors associated with the progression to brain death in critically ill patients with severe brain injuries in Tunisian intensive care units (ICUs). The main questions it aimed to answer were: What medical factors (e.g., type of brain injury, ICU stay duration) increased the likelihood of progressing to brain death in these patients? What patient characteristics (e.g., age, comorbidities) influenced the risk of brain death? What were the reasons behind low organ donation rates in Tunisia, … |
IMEN SLAMA; | 2022-11-01 |
| 151 | Formation of Reactive Oxygen Species in Patients With Severe Traumatic Brain Injury in Normal Vs Increased Oxygenation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project an observational study performed on patients with severe Traumatic Brain Injury (TBI) treated at Neurosurgical ICU (NICU) at Karolinska University Hospital. The purpose of this study is to evaluate the effects of various oxygenation levels on production rate of Reactive Oxygen Species (ROS) in patients with severe traumatic brain injury (TBI). The patients will be included in the study after the placement of intracranial monitoring device consisting of intracranial pressure gage (Codman), microdialysis (MD), … |
REGION STOCKHOLM | 2022-11-01 |
| 152 | Evaluation of Neurosteer System (Quantitative EEG Features) in Stroke Patients Suffering From Disorders of Consciousness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through a series of EEG recordings during their hospitalization. EEG recordings will be analyzed using proprietary computational analyses. |
GAL IFERGAN; | 2022-11-01 |
| 153 | Does Glutamine Therapy Have A Positive Effect on Traumatic Brain Injury Patients?Double Blinded Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Glutamate is an important neurotransmitter present in over 90% of all brain synapses and is a naturally occurring molecule that nerve cells use to send signals to other cells in the central nervous system. Glutamate is a non-essential amino acid with restricted passage to the brain from the blood. In the CNS, glutamate is synthesised in neurons as part of the glutamate-glutamine cycle.5,6 so it plays an essential role in normal brain functioning and can improve situations related to impaired cognitive,motor and emotional functions and can be used to improve traumatic brain injury patient general health status |
ENGY RAAFAT YOUSSIF; | 2022-10-30 |
| 154 | Phase IIa Trial of A Selective Glucocorticoid Receptor Antagonist in The Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is large body of evidence demonstrating that Posttraumatic Stress Disorder (PTSD) is associated with alterations in the stress hormone cortisol. There is also evidence that medications that block cortisol may be beneficial for treating PTSD and depression. The VA recently completed a study of a mifepristone, a medication that blocks cortisol and progesterone hormones, … |
THOMAS C. NEYLAN; | 2022-10-15 |
| 155 | Effect of High-Intensity Gait Training Using A Treadmill on Locomotion Recovery in Traumatic Brain Injury Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The project will consist of subjects who have suffered Traumatic Brain Injury (TBI) and who are able to ambulate on treadmill with or without a harness system. This will be a 4-week controlled study consisting of two groups of TBI patients, high-intensity intervention group and low-intensity control group. Both groups will receive physical therapy treatment 3 times per week for 1 hour. The intervention group will undergo 30-minute sessions of high-intensity walking on a treadmill with an overhead harness attached for safety. In addition, … |
COURTNEY PERKINS; | 2022-10-07 |
| 156 | Mindfulness-Based Intervention for Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mindfulness is a promising tool which may foster adaptative interpersonal qualities to reduce the risk of persistent post-concussion symptoms. The present feasibility study will customize and validate a mindfulness mobile smart-phone app easily accessible to youth and families. The study will also determine whether mindfulness training increases quality of life, reduces symptom burden and promotes neurophysiological recovery at 4 weeks post-injury in adolescents who were diagnosed with an acute concussion compared to a cognitive sham app + usual care. |
ANDREE-ANNE LEDOUX; | 2022-10-04 |
| 157 | Returning to Everyday Tasks Utilizing Rehabilitation Networks-III Pilot Randomized Clinical Trial (RETURN-III Pilot RCT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Millions of patients survive care in medical and surgical Intensive Care Units (ICUs) every year, only to suffer from a new or accelerated dementia-like process, called post-ICU long-term cognitive impairment (ICU-LTCI). ICU-LTCI causes considerable problems with personal relationships, return to work, and everyday tasks, such as managing medicines and money. No treatment for these patients is currently available. Technology using computerized cognitive rehabilitation could improve ICU-LTCI by harnessing the healing potential of the brain (i.e., neuroplasticity). This intervention is scalable, portable, … |
E. WESLEY ELY; | 2022-10-03 |
| 158 | A Highly Portable Device for Assessment of Mild Traumatic Brain Injury in Deployed and Far-Forward Settings PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop a highly portable, ruggedized diagnostic tool for concussion, EyeBOX Lens (EBLens), that can be utilized in deployed field and far-forward settings. The EBLens will be based on a concussion diagnostic algorithm from the FDA cleared EyeBOX device, developed by Oculogica, and eye-tracking data collected from a wearable set of eye-tracking glasses, developed by Adhawk Microsystems. Once the EBLens is prototyped, an algorithm for diagnosing concussion will be developed that is specifically appropriate for the EBLens via a case-control clinical study comparing 100 concussed to 100 non-concussed subjects (Phase I). Participants, … |
KENNETH CAMERON; | 2022-10-01 |
| 159 | Use of Cerebral Biomarkers in Minor Traumatic Brain Injury in The Emergency Unit PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The use of serum biomarkers in the setting of the emergency department (ED) has been well characterized over the years as an adjunctive tool for the clinician in the setting of complex decision making. In this regard, the serum dosage of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) has been evaluated in a series of successful multicenter prospective studies as a potentially useful marker of, respectively, glial and neuronal damage in the setting of mild traumatic brain injury (mTBI), … |
COVINO MARCELLO; | 2022-10-01 |
| 160 | Traumatic Extradural Hematoma in Paediatric Age Group PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess the clinical and radiological characteristics of children with traumatic extradural hematoma and factors affecting the initial neurological status and outcome. |
MOHAMED ASHRAF SALAH; | 2022-10-01 |
| 161 | Effects of Usage of Simvastatin in Mild to Moderate Traumatic Brain Injury (TBI) Patients. Could It Make A Difference? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is a common cause of long-term neurological morbidity, with devastating personal and societal consequences. At present, no pharmacological intervention clearly improves outcomes, and therefore a compelling unmet clinical need remains. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, offer a potential novel therapeutic strategy for TBI. In this study the investigators will study primarily the effect of statins on 30-day mortality rate which is defined as death within 30 days of TBI presentation where the occurrence of TBI is hour 0 or day 0 and secondarily evaluation of duration of ICU stay associated with or without complications. |
MUHAMMAD HAMDI TAHA MUHAMMAD; | 2022-10-01 |
| 162 | The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms – A Pilot Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study, is to investigate whether creatine monohydrate as a supplement reduces the number and severity of symptoms in patients with persistent post-concussive symptoms through self-reported post-concussion symptoms questionnaires. |
MICHAEL HAURUM MARCUSSEN; | 2022-10-01 |
| 163 | Percutaneous Neurostimulation for Treatment of Paroxysmal Sympathetic Hyperactivity in Children With Acute Severe Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Survivors of severe brain injury, such as lack of oxygen or severe traumatic brain injury, frequently experience Paroxysmal Sympathetic Hyperactivity (PSH). PSH is characterized by disabling symptoms such as a fast heart rate, high blood pressure, rapid breathing, rigidity, tremors, and sweating due to uncontrolled sympathetic hyperactivity in the nervous system. Effective treatment is necessary to decrease secondary brain injury, prevent weight loss from increased metabolic demand and reduce suffering. Currently, a combination of medications to slow down the sympathetic nervous system, muscle relaxants, anti-anxiety drugs, gabapentin, and narcotics are used to treat PSH. The sudden, … |
BINOD BALAKRISHNAN; | 2022-09-22 |
| 164 | The Effect of Reiki on Treatment Compliance, Eating Behaviors and Metabolic Values in Obese Individuals With Type 2 Diabetes: Randomized Controlled Study Related Papers Related Patents Related Grants Related Experts View Highlight: The increase in the prevalence of diabetes and the loss of various organs and functions in the individual as a result of complications caused by diabetes affect the life expectancy and quality of individuals, and cause social and economic losses affecting the whole society. For this reason, the individual management of the diabetic patient is important in terms of ensuring effective participation and compliance in treatment and care. Patients must have knowledge, skills and positive attitudes in order to successfully comply with diabetes treatment. Patients are in compliance with diabetes treatment; they encounter some barriers such as medication barriers, … |
FATMAZ ZEHRA KÜÇÜK; | 2022-09-15 |
| 165 | Simvastatin Nasal Rinses for The Treatment of COVID-19 Mediated Dysomsia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Olfactory dysfunction (OD) or changes in smell and/or taste is one of the cardinal presenting symptoms of COVID-19. Despite the prevalence of COVID and resultant OD, the pathophysiology of COVID-mediated OD is not fully understood, … |
NYSSA FARRELL; | 2022-09-01 |
| 166 | Euthyroid Sick Syndrome (ESS)….. Can It Influence Morbidity and Mortality in Moderate to Severe Traumatic Brain Injury Patients or Correlate With Glial Fibrillary Acidic Protein (GFAP) Level PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Euthyroid sick syndrome (ESS) effects on patients suffering from traumatic brain injury (TBI) have received little attention. Moreover, there is limited evidence that serum levels of thyroid-related hormones might influence functional outcome in the acute phase of brain damage. However, the relationship is complex, and the relevance for functional outcome and the question of therapeutic interventions remain the subject of ongoing researches . Historically, a wide range of brain damage markers have been examined in TBI patients. However, owing to the limited tissue specificity and other concerns, most markers, including neuro-specific enolase and S100B protein, … |
MOHAMED HAMEED MOHAMMED; | 2022-09-01 |
| 167 | Effect of Balance Training on White Matter Tracts in Healthy Elderly Population PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Balance impairment increases the risk of falling and is associated with a fear of falling and immobility. Balance impairment can ultimately affect the morbidity of cardiovascular disease, cognitive impairment, and mortality, especially in an older population. Among the multiple types of exercise, balance training is the most effective in preventing falls. This study aims to investigate white matter plasticity in healthy elderly population, based on stepwise balance training. Healthy elderly participants will undergo four weeks of balance training. The investigators will analyze longitudinal changes in the microstructural integrity of the white matter tracts pre- and post-training. |
YOUNGKOOK KIM; | 2022-08-24 |
| 168 | Effect of Early Coma Arousal Therapy on Conscious Level Recovery and Cognition in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: PURPOSE: The aim of this study is to investigate the effect of early coma arousal therapy on conscious level and cognitive function in sever traumatic brain injury patients. BACKGROUND: Traumatic brain injury (TBI) could be simply defined as an alteration in brain function due to external forces and is considered as one of the leading cause of death and disability worldwide, especially among young adults and the elderly. Current estimates imply that annual incidence of TBI is 50-60 million worldwide, and specifically for Europe and USA, … |
MUSTAFA SAMIR MOHAMED AMIN SAYED; | 2022-08-23 |
| 169 | Promoting Recovery in Children Who Sustain A Mild Traumatic Brain Injury: MTBI Evaluation and Management (TEaM) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate a multi-disciplinary, multi-setting intervention with the goal of improving outcomes for children who have experienced a mild traumatic brain injury (mTBI). The project aims to improve and support mTBI diagnosis and management, and improve critical decision making by clinicians during their interaction with the injured child, their family, and their school. |
DAVID WRIGHT; | 2022-08-19 |
| 170 | Post-Brain Injury Walking and Balance Recovery Program PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test the efficacy of a walking and balance training program designed to safely challenge and improve walking performance and balance in relation to walking speed, strength, endurance, and balance after traumatic brain injury (TBI). The aim and primary hypothesis of this research project is: Aim) Test and implement a new personalized intervention strategy, in addition to usual and customary care at an inpatient rehabilitation clinic, to improve patient outcomes with secondary conditions associated with impaired balance and walking that typically occur post brain injury. After validation of the locomotor Battery of tests, … |
THE UNIVERSITY OF TEXAS MEDICAL BRANCH GALVESTON | 2022-08-18 |
| 171 | ADEPT: Adaptive Trial for The Treatment of Depressive Symptoms Associated With Concussion Using Repetitive Transcranial Magnetic Stimulation Protocols Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare different types of repetitive transcranial magnetic stimulation (rTMS) that may alleviate depressive symptoms in United States Military Service Members with a history of concussion. |
DAVID L BRODY; | 2022-08-17 |
| 172 | Feasibility of Using Remotely-delivered Metacognitive Strategy Training to Address Cancer-related Cognitive Impairment in Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The first aim of this study is to determine the feasibility of delivering CO-OP remotely to breast cancer survivors, who self-report cancer-related cognitive impairment (CRCI), in preparation for a future R01 trial. The second aim of this study is to assess the effect of CO-OP on activity performance, subjective and objective cognition, and quality of life in a sample of breast cancer survivors who self-report CRCI. The research team hypothesizes that effect size estimations will indicate that CO-OP will have a greater positive effect, compared to attention control, on activity performance, subjective and objective cognition, … |
ANNA BOONE; | 2022-08-09 |
| 173 | The Specificity and Sensitivity of CircMETTL9 Gene in Patients With Traumatic Brain Injury, Its Correlation With Cognitive Function and Disturbance of Consciousness, and Prognosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: The relevance of circMETTL9 to the degree of injury, disturbance of consciousness, cognitive function and prognosis in patients with moderate to severe traumatic brain injury (TBI) remains unknown. The purpose of this study was to investigate the effect of circMETTL9 on the degree of injury, disturbance of consciousness, cognitive function and prognosis after TBI. |
AFFILIATED HOSPITAL OF NANTONG UNIVERSITY | 2022-08-04 |
| 174 | BRAINI2-Paediatric : Blood Biomarkers to Improve Management of Children With Traumatic Brain Injury: A European, Prospective, Multicentre Clinical Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild traumatic brain injury (TBI), defined by a Glasgow Coma Scale (GCS) score of 13 to 15, is the cause of many consultations in paediatric emergency departments (1), even though it is a rare cause of acute complication: approximately 10% of children present with intracranial lesions (ICL) on the CT scan and less than 1% require neurosurgical intervention (2). Although ICLs remain a serious complication requiring rapid diagnosis, brain CT scans, the gold standard diagnostic test, … |
FLEUR LORTON; | 2022-08-02 |
| 175 | Impact of Intermediate Normal Compared to High Normal Oxygen Levels on Outcomes of Patients Presenting in The Emergency Department With Severe Traumatic Brain Injury (INACHOS): A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite almost universal usage of supplemental oxygen therapy in patients presenting in the emergency department with traumatic brain injury (TBI), optimal oxygen levels are unclear. The investigators propose a pilot multi-center randomized controlled trial to test the hypothesis that maintaining intermediate normal as opposed to high normal oxygen levels in patients presenting in the emergency department with TBI is feasible, and to obtain preliminary data on the efficacy of the two approaches to oxygen therapy. The aim is that the investigators produce pilot data, which could inform the design of potential subsequent larger clinical trials. |
ILIAS SIEMPOS; | 2022-08-01 |
| 176 | Measures of Cortical Excitability in Patients With Post-traumatic Epilepsy, Traumatic Brain Injury Patients Without Epilepsy, and Healthy Controls: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To test whether measures of cortical excitability derived from motor cortex transcranial magnetic stimulation (TMS) in patients with traumatic brain injury reflect heightened excitability relative to healthy controls and whether such measures can be used to distinguish patients with post-traumatic epilepsy from patients with head trauma but no epilepsy |
PAVEL KLEIN; | 2022-08-01 |
| 177 | Advanced Resting State FMRI for Clinical Evaluation of Brain Network Integrity in Disorders of Consciousness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Disorders of consciousness (DoC) remain a major clinical challenge in which high rates of misdiagnosis and difficult prognostication stem from limitations in the ability to access the disordered physiological processes mechanisms of coma in real world clinical settings. There is a great need to develop, validate, and translate to clinical use reliable diagnostics to detect brain recovery potential not evident on neurobehavioral assessment. While resting state fMRI (rs-fMRI) has demonstrated potential to improve the diagnostic evaluation of DoC by detecting features of consciousness that are occult at bedside evaluation, … |
JEFFERY WARE; | 2022-08-01 |
| 178 | Combination Treatment With Cerebrolysin and Amantadine on Prolonged Disorders of Consciousness in Patients With Severe Traumatic Brain Injury: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Object: To demonstrate the combined effect of cerebrolysin and amantadine on prolonged disorders of consciousness in patients with severe traumatic brain injury Participants: patients with prolonged disorders of consciousness due to severe traumatic brain injury Intervention: amantadine only (100mg to 200mg bid) or cerebrolysin only (30ml qd) or amantadine (100mg to 200mg bid) plus cerebrolysin (30ml qd) Comparison: amantadine only group versus cerebrolysin only group versus amantadine plus cerebrolysin group Outcome: Coma Recovery Scale-revised, FDG-PET signal |
JONGMIN LEE; | 2022-08-01 |
| 179 | Effects of Nurse-Guided Brief Behavioral Treatment for Insomnia on Sleep, Mood, and Cognition: Model Establishment and Application in Patients at The Recovery Phase Following Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: nsomnia is a frequent complaint reported by patients with TBI, and exacerbates their ability to return to productive activity, which subsequently elevate related healthcare costs and burden. Existing literatures found that effects of CBTi, first-line therapy for insomnia, on post-traumatic insomnia is still debated, indicating that developing an alternative nonpharmacological therapy for alleviating insomnia following TBI is required. Besides, digital health is one of strategies to achieve precision health. Thus far, knowledge regarding whether mobile-delivered BBTi has non-inferiority effects as BBTi in treating insomnia is still lacking. Therefore, … |
HSIAO-YEAN CHIU; | 2022-08-01 |
| 180 | Acceptability, Feasibility, Usability, and Effectiveness of A Mindfulness Intervention in Young Adults With A Concussion History: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Young adults (aged 18-30) with a concussion history (defined as experiencing a concussion within the past five years but not within the past month) will complete a six-week mindfulness intervention. Throughout the intervention, participants will complete 10-20 minutes of mindfulness-focused exercises and meditations each day using the LoveYourBrain Foundation Meditation Library. Before the intervention, participants will complete a baseline assessment including demographics, concussion history, mental health history, mindfulness history, perceived stress, mindfulness, and concussion symptoms. Throughout the intervention, participants will complete weekly assessments measuring adherence and concussion symptoms. After six weeks, participants will complete a final, … |
CHRISTINE E CALLAHAN; | 2022-07-25 |
| 181 | Effects of Systemic Blood Pressure Targets on Cerebral Hemodynamics in Septic Shock: A Prospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The sudy objective is to evaluate the cerebral haemodynamic status in different ranges of systemic arterial pressure in patients with septic shock by noninvasive tools, transcranial doppler and intracranial compliance by mechanical sensor (B4C). Patients participating in the study will be submitted to different levels of arterial pressure, titrated with vasopressor and them their cerebral hemodynamic variables will be evaluated, |
JULIANA CALDAS; | 2022-07-07 |
| 182 | Prognostic Value of Pediatric GCS-Pupil Score in Pediatric Patients With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There are studies reporting that the survival rate in pediatric patients with abnormal pupillary response is 23% and that pupillary response is effective on mortality and patient outcomes. Studies in the literature examining the effect of pupillary response on mortality and outcome in pediatric patients with traumatic brain injury reported that bilaterally dilated pupils were associated with a higher mortality rate. Considering the literature results, we believe that obtaining the GCS-Pupil score by combining GCS and pupillary reaction in pediatric patients with traumatic brain injury will be effective in predicting patient outcomes. |
AKİF BULUT; | 2022-07-01 |
| 183 | A Single-Blind, Randomized, Controlled Trial of A Cognitive-Behavioral Therapy Digital Therapeutic to Combat Symptoms of Depression in Service Members and Veterans With A History of Mild Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Center for Neuroscience and Regenerative Medicine (CNRM) Clinical Trials Unit has developed the first cognitive-behavioral therapy (CBT) digital therapeutic (DTx) mobile application to counteract depressive symptoms in military service members and veterans with a history of mild traumatic brain injury (mTBI). This trial will assess the efficacy of the novel CBT-DTx for depression following mTBI compared to an educational comparison DTx. |
DAVID BRODY; | 2022-06-22 |
| 184 | Efficacy of Lung and Inferior Vena Cava Sonography for Fluid Optimization in Critically Ill Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is a leading cause of death and disability in trauma patients. As the primary injury cannot be reversed, management strategies must focus on preventing secondary injury by avoiding hypotension and hypoxia and maintaining appropriate cerebral perfusion pressure (CPP), … |
MANSOURA UNIVERSITY | 2022-06-15 |
| 185 | Evaluation of Neuroprotective Effect of Dexmedetomidine in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: patient wih mild to moderate traumatic brain injury in ICU will be randomisly distributed into two groups Group I (control group): Patients of this group receive placebo infusion for 72 hours. Group II (DEX group): Patients of this group receive 0.5 ug/kg/hr dexmedetomidine continuous infusion for 72 hour Patient demographics, including age, sex, weight, primary diagnosis, … |
WAFAA MADHY ATIA ABDELWAHED; | 2022-06-04 |
| 186 | Oral Versus Nasal Enteral Nutrition on Severe Traumatic Brain Injury Patients With Tracheostomy: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding (n=50) or the control group with Nasogastric tube feeding (n=48) for enteral nutrition support, respectively. Nutritional status, complications, decannulation of tracheostomy tubes and level of consciousness on day 1 and day 28 were recorded and compared. |
MUHAMMAD | 2022-06-01 |
| 187 | A Randomized Controlled Study to Explore The Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding (n=50) or the control group with Nasogastric tube feeding (n=48) for enteral nutrition support, respectively. Nutritional status, complications, decannulation of tracheostomy tubes and level of consciousness on day 1 and day 28 were recorded and compared. |
HONGJI ZENG; | 2022-06-01 |
| 188 | A Randomized Controlled Study to Explore Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding (n=50) or the control group with Nasogastric tube feeding (n=48) for enteral nutrition support, respectively. Nutritional status, complications, decannulation of tracheostomy tubes and level of consciousness on day 1 and day 28 were recorded and compared. |
ZENG CHANGHAO; | 2022-06-01 |
| 189 | Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery (TASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Subdural Hematoma (cSDH) is an extremely common problem, particularly in the aging population, where fluid like collections compress the brain, frequently requiring surgical drainage. After drainage, 25-50% of patients experience post operative neurologic deficits such as weakness or confusion that are often not explained by problems such as seizure, stroke, or mass effect from the fluid and blood. Recent subdural recordings have demonstrated that some of these neurological deficits may be related to waves of spreading depolarization (SD), … |
ANDREW PHILLIP CARLSON; | 2022-06-01 |
| 190 | To Compare The Effect of Receiving The Technology-based Training Along With The Conventional Therapy to The Conventional Therapy Alone on Executive Functions Among People With Traumatic Brain Injury With Mild to Moderate Cognitive Deficit: A Pilot Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effect of receiving the technology-based training along with the conventional therapy to the conventional therapy alone on executive functions among people with traumatic brain injury with mild to moderate cognitive deficit. It aims to answer: – If there is significant improvement in executive function skills among people with traumatic brain injury receiving technology-based training along with conventional therapy when compared to people with traumatic brain injury receiving conventional therapy alone. – … |
HAMAD MEDICAL | 2022-05-25 |
| 191 | To Investigate The Effects of Vestibular Rehabilitation Exercise on Dizziness, Body Balance, Post Concussion Syndrome, Anxiety and Quality of Life in Patients With Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is a leading cause of long-term disability and mortality. The costs associated with hospitalization, rehabilitation, and productivity losses after injury impose a significant socioeconomic and healthcare burden. TBI patients often struggle with symptoms such as dizziness and post-concussion syndrome, preventing them from returning to their previous level of functioning. This leads to negative consequences, including unemployment, psychosocial adjustment difficulties, and decreased quality of life, particularly affecting young working-age individuals. The purpose of this study was to investigate whether vestibular rehabilitation exercises for mild traumatic brain injury (mTBI) patients could improve symptoms of dizziness, post-concussion syndrome, … |
HUI-CHUN LIAO; | 2022-05-20 |
| 192 | The Impact of Early Use of Tranexamic Acid in Traumatic Brain Injury Upon The Inflammatory Response and Outcome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, our aim is to investigate the role of tranexamic acid for modulating the inflammation in patients with traumatic brain injury (TBI). |
OMAR MAKRAM SOLIMAN; | 2022-05-18 |
| 193 | Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the feasibility and safety of using the ketogenic diet (KD) in children who sustained moderate to severe traumatic brain injury (TBI). The secondary objective is a preliminary evaluation of the outcomes of children who have had the standard of care plus the KD, compared to those with standard of care alone. Outcome measures for the secondary objective will include: need for ventriculoperitoneal shunt, duration of unconsciousness, need for any type of craniotomy, duration of post-traumatic amnesia, acute hospitalization length of stay, … |
LINDA KRACH; | 2022-05-16 |
| 194 | Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial Related Papers Related Patents Related Grants Related Experts View Highlight: This research is being done to find out if the study drug (posaconazole) can enter brain tumors at a high enough amount to stop the tumor cells from dividing. Posaconazole is a drug which doctors already use for fungal infections and is thought to be able to effect tumor cells. As treatments for this type of brain tumor are limited, it is hoped that the results of this study will help to determine if the study drug should be studied further as a possible treatment. |
ALIREZA MANSOURI; | 2022-05-13 |
| 195 | Comparison of Image Quality Between Ultra-low Dose (ULD) and Standard Dose CT Scans in Detecting Traumatic Brain Injury in The Emergency Room PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Head trauma is a frequent reason for consultation in the emergency room. The CT scan is the reference examination allowing rapid management of the patient. However, CT examinations are among the diagnostic examinations with the highest exposure to ionizing radiation. The study investigators have previously implemented ultra-low dose (ULD) acquisitions for several pathologies with an effective dose level similar to that of a standard radiographic examination. These ULD acquisitions are now routinely used in our clinical practice for explorations of the thorax, spine, pelvis and proximal femurs, … |
NICOLAS MENJOT DE CHAMPFLEUR; | 2022-05-12 |
| 196 | Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas: A Phase 0 Clinical Trial Related Papers Related Patents Related Grants Related Experts View Highlight: This research is being done to find out if the study drug (ketoconazole) can enter brain tumors at a high enough amount to stop the tumor cells from dividing. Ketoconazole is a drug which doctors already use for fungal infections and is thought to be able to effect tumor cells. As treatments for this type of brain tumor are limited, it is hoped that the results of this study will help to determine if the study drug should be studied further as a possible treatment. |
ALIREZA MANSOURI; | 2022-05-11 |
| 197 | Establishment of A Clinical Efficacy Prediction System Based on The Role of Meningeal Lymphatic Vessels in The Absorption of Chronic Subdural Hematoma and Its Injury Mechanism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic subdural hematoma (CSDH) is a very common hemorrhagic disease of the nervous system, accounting for about 10% of hemorrhagic strokes. The incidence rate of elderly people over 65 years old is 58.1/100,000, and the incidence rate is increasing year by year, and it may reach 121/100,000 by 2030. At present, the specific pathogenesis of CSDH is still unclear. Although it has been clinically confirmed that a part of CSDH can be absorbed by itself, and some drugs such as atorvastatin can speed up the process, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2022-05-02 |
| 198 | Roll for Intervention – A Critical Look at The Practicability of Table-top Roll Playing Games As Communication Intervention for Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Communication group intervention for individuals with Traumatic Brain Injury based on INSIGHT protocol (Keegan et al, 2020) with roll playing game focus |
LOUISE KEEGAN; | 2022-05-02 |
| 199 | The Predictive Role of Glucose/Potassium Ratio for Mortality in Patients With Major Burn Trauma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this observational study is to investigate the role of the glucose-potassium ratio in predicting mortality in patients with major burn trauma. The main question it aims to answer is: Can the glucose-potassium ratio predict mortality in major burn patients? The glucose-to-potassium ratios of major burn patients at the time of initial hospitalization will be determined, and their relationship with mortality will be analyzed. |
ALPASLAN ŞAHIN; | 2022-05-01 |
| 200 | Effect of Refined Nursing in Rehabilitation Training for Patients With Brain Injury During The Recovery Period: An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to explore the clinical effect of refined nursing in rehabilitation training for patients with brain injury during the recovery period. Patients in the control group were provided with routine nursing intervention, while patients in the study group adopted a nursing mode based on the concept of refinement treatment. Comparison was made in terms of the Glasgow Coma Scale (GCS) score, cognitive function score, functional independence score, nursing satisfaction, and incidence of complications. |
JIE YANG; | 2022-05-01 |
| 201 | Evaluating The Effectiveness Of A Community Support Network Intervention For PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intimate Partner Violence (IPV) comprises physical, sexual and emotional abuse and controlling behaviors imposed by an intimate partner. It is estimated that up to 92% of women who survive IPV may have suffered one or more traumatic brain injuries (TBI) from blows to the head, face, and neck, and/or anoxia or hypoxia due to strangulation. Even mild TBI may manifest as alternations in consciousness, black out, dizziness, disorientation, anxiety, depression, post-traumatic stress disorder, muscles weakness or paralysis and deficits in memory, attention, … |
PAUL VAN DONKELAAR; | 2022-05-01 |
| 202 | Summative Usability Study of CEREBO® in Traumatic Brain Injury Patients to Determine Ease of Use, Ease of Learning and Satisfaction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic Brain Injury (TBI) is the leading cause of death and disability across the globe. Time from injury to treatment is the most critical factor that determines the patient’s recovery. Mild TBI with no apparent symptoms are often left undiagnosed, thus delaying the treatment and hence recovery. CEREBO® is a non-invasive, rapid, near-infrared based, point-of-care device that can detect an intracranial bleed at an early stage. |
JAIMIN SHAH; | 2022-04-25 |
| 203 | Non-Invasive Monitoring of Traumatic Brain Injury Progression Using The Infrascanner (MOBI-1) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: MOBI-1 is a multicenter clinical trial that will evaluate the use of the Infrascanner for the monitoring of traumatic intracranial hematomas. |
JAN O. JANSEN; | 2022-04-18 |
| 204 | Interest in The Implementation of A Systematic Protocol for The Dosage of The S100B Protein in The Reduction of The Use of Brain Scans for Patients With Mild Traumatic Brain Injury in The Emergency Room of Douai Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective is to evaluate the feasibility and interest of setting up a protocol for the systematic measurement of the S100B protein in patients with mild traumatic brain injury admitted to the emergency room of Douai hospital in order to reduce the number of unnecessary brain scans. The main evaluation criterion is the percentage of patients admitted to the emergency department of Douai hospital for mild traumatic brain injury, … |
JUSTINE HERENG; | 2022-04-06 |
| 205 | Dry Needling Effects on Spasticity and General Functioning in Patients With Traumatic Brain Injury: A Case Study Related Papers Related Patents Related Grants Related Experts View Highlight: Thirty-six years old male with a history of TBI with compromised functionality of the right upper and lower limbs, spasticity, distributed balance, and difficulties performing independent gait has participated in the study. Berg balance scale, 6-minute walk test, modified Ashworth scale, and functional independence measure was used to assess balance, gait, spasticity, and functional intemperance, respectively. |
ANAS RADI HASSAN ALASHRAM; | 2022-04-05 |
| 206 | A Prospective, Double Blind, Randomized, Sham-Controlled, Clinical Trial to Evaluate The Safety And Efficacy Of Biometrics-Guided Magnetic EEG Resonance Therapy (MeRT) Treatment Of Post-Traumatic Stress Disorder With And Without Persistent Post-Concussive Symptoms (PPCS) Following Traumatic Brain Injury (TBI) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and efficacy of individualized, Biometrics-guided Magnetic e-Resonance Therapy (MeRT) treatment of Post-Traumatic Stress Disorder with and without Persistent Post-Concussive Symptoms (PPCS) following Traumatic Brain Injury (TBI). |
KENNETH RAMOS; | 2022-04-04 |
| 207 | Non-invasive Neuro-monitoring for Head Injury: Use of Near Infra-red Spectroscopy for Early Detection of Delayed Intracranial Haematoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fall with head injury is becoming an epidemic challenge especially with the ageing population. Contributing factors for mortality and poor functional outcome included development of cerebral contusion and delayed traumatic intracerebral haematoma. There is a higher prevalence especially with the increasing use of antiplatelets and anticoagulants. Non-invasive monitoring such as near-infrared spectroscopy (NIRS) is sensitive in detecting intracranial changes. The role and efficacy of this non-invasive method has not been specifically established in patients with head injury as an initial non-operative monitoring. This is particular important in the setting of a general ward in which nursing staff is limited. The advantages of these noninvasive monitoring might have a role of continuous neuro-monitoring. They can also potentially reduce the number of unnecessary repeated CT Brain in the context of limited radiology staff and resources. Timely detection and treatment of this condition accordingly is crucial. Potential options of non-invasive monitoring such as nearinfrared spectroscopy (NIRS) is to be investigated. The aim of this study is to determine the sensitivity and specificity of NIRS as a non-invasive monitoring in detecting delayed intracranial injuries in comparison with the Gold Standard CT Brain. Study design is Prospective sensitivity and specificity study of Near Infra-red Spectroscopy (NIRS) as a non-invasive monitoring in detecting delayed intracranial injuries in comparison with the Gold Standard CT Brain in Hong Kong Chinese. Consecutive patients admitted to Prince of Wales Hospital, Hong Kong would be recruited. Outcome measures including correlation of non-invasive monitoring with near-infrared spectroscopy (NIRS) to CT Brain findings including any increase in haematoma size, cerebral edema or mass effect. Secondary outcome including 30 days mortality and functional outcome at 3 months. |
DAVID YUEN CHUNG CHAN; | 2022-04-01 |
| 208 | The Effects of Hyperbaric Oxygen on Moderate and Severe Non-acute Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) continues to be a major cause of death and disability throughout the world. The reduced cerebral blood flow secondary to the direct trauma-induced damage deregulates cerebral metabolism and depletes energy stores within the brain. Diffusion barriers to the cellular delivery of oxygen develop and persist. Besides, TBI often leads to intracranial hypertension, which in turn exacerbates diffusion disorders, further reducing cerebral oxygenation, and deteriorates the injury. By increasing the partial pressure of oxygen in blood, reducing intracranial pressure and cerebral edema, Hyperbaric oxygen therapy (HBO2) has been used in early treatment of TBI. However, … |
BING XIONG; | 2022-03-23 |
| 209 | Cold Stored Platelet Early Intervention in Traumatic Brain Injury Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Cold Stored Platelet Early Intervention in Traumatic Brain Injury (CriSP-TBI) trial is a proposed 3 year, open label, single center, randomized trial designed to determine the feasibility, efficacy, and safety of urgent release cold stored platelets (CSP) in patients with TBI requiring platelet transfusion. Patients will be randomized to receive either standard care or early infusion of urgent release cold stored platelets (CSP). The proposed pilot study will enroll at the University of Pittsburgh and will enroll approximately 100 patients. The primary outcome for the pilot trial is feasibility, … |
JASON SPERRY; | 2022-03-21 |
| 210 | Cohort Study on The Effects of Aging in Acquired Brain Injury Patients PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective cohort study (questionnaires), with an embedded case control study (neuropsychological assessments) in which the data is gathered within a timeframe of 3 years. A group of 700 patients and a group of 100 healthy volunteers will be participating. |
JOUKJE VAN DER NAALT; | 2022-03-18 |
| 211 | Elucidate The Mechanisms, Development and Effectiveness of Balance Control and Gait Strategy After Mild Traumatic Brain Injury: Develop Innovative Design of Computerized Dual-task Balance Module PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to innovatively design and develop computerized dual-task balance training modules and home modules, and conduct proactive clinical verification to focus on the effectiveness of balance control and gait stabilization strategies. It is expected that in addition to the development of the training module, a proactive study will be conducted at the same time. During the period from the fourth quarter of the first year to the second year, there will be 25 patients in the experimental group and 25 patients in the control group. A total of 50 patients will undergo preliminary efficacy analysis. |
LI-FONG LIN; | 2022-03-16 |
| 212 | Safety and Cognitive Effects of Acute Intermittent Hypoxia-Induced Neuroplasticity in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to answer questions related to safety and preliminary efficacy of Acute Intermittent Hypoxia (AIH) in Traumatic Brain Injury (TBI) survivors. First, we aim to establish whether brief reductions in inhaled oxygen concentration can be safely tolerated in TBI survivors. Second, we aim to establish whether there are any effects of AIH on memory, cognition, and motor control. Participants will be monitored closely for any adverse events during these experiments. Data will be analyzed to determine if there is an improvement in key outcomes at any dose level. |
JORDAN GRAFMAN; | 2022-03-15 |
| 213 | Effect of Fixed Vs. Tailored Intensity Transcranial Direct Current Stimulation for Attention Deficit After Traumatic Brain Injury: A Single Center, Prospective, Double Blind, Randomized-Controlled Clinical Trial, Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is an important global health concern. Recently, advances in neurocritical care have led to an increase in the number of recovering TBI patients, and concomittantly in the incidence of complications of TBI. One of the most important sequalae of TBI is cognitive deficit, for which multimodal rehabilitation approach is indicated. Transcranial direct current stimulation (tDCS) is a promising treatment strategy for post-TBI cognitive deficits. However, a standardized tailored tDCS protocol is yet to be established for TBI patients. Therefore, this trial aims to 1) the efficacy of tDCS on post-TBI cognitive deficits, … |
BYUNG-MO OH; | 2022-03-14 |
| 214 | The Effect of Intravenous Lidocaine Infusion on Hemodynamic Reaction to Tracheal Intubation, As Well As Metabolic and Hormonal Response to Laparoscopic Procedure in Children: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Intravenous lidocaine – a potent local anesthetic with analgesic and anti- inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management in adults. In children population promising but limited evidence is available. The study has been planned to evaluate the efficacy of continuous intravenous infusion of lidocaine in alleviation of hemodynamic reaction to tracheal intubation, as well as metabolic and hormonal response to laparoscopic procedure in children. |
MACIEJ KASZYŃSKI; | 2022-03-12 |
| 215 | Correct Timing of Head Imaging in Trauma PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aims of this retrospective and monocentric observational study are: to describe patient characteristics and clinical management of patients with traumatic brain injury taking antiplatelet and/or anticoagulation drugs; to estimate the proportion of patients who suffer an adverse outcome; to assess the risk for serious events (intracranial haemorrhage, in-hospital mortality, need for surgery); to identify potential predictors of outcome and assess potential differences between anticoagulation and antiplatelet therapy. All patients with mild brain injury and anticoagulant or antiplatelet therapy who underwent a head computed tomography (CT) scan admitted to the emergency department (ED) of the University Hospital of Padova, Italy, … |
GIULIA BERTI DE MARINIS; | 2022-03-01 |
| 216 | Blood Biomarkers to Improve Management of Mild Traumatic BRAIN Injury in The Elderly PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild traumatic brain injury (mTBI) is one of the most frequent emergencies in the elderly population. Despite most mTBI are managed with cranial computed tomography (CT), only 10% of CTs show lesions, … |
ALFONSO LAGARES GÓMEZ-ABASCAL; | 2022-03-01 |
| 217 | A Feasibility Study of Behavioral Activation in The Rehabilitation of Veterans With Post-TBI Depression PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Depression is common after traumatic brain injury (TBI) and may have wide-ranging consequences. Post-TBI depression may impede reintegration into the family and community and lead to lower quality of life and heightened suicide risk. It may also interfere with rehabilitation. Yet, current treatments for post-TBI depression are based largely on expert opinion rather than evidence from rigorous studies. Behavioral activation (BA) is a promising intervention for post-TBI depression. It is a brief behavioral treatment that helps people define goals, create and execute plans to reach them, … |
HELENE J MORIARTY; | 2022-02-15 |
| 218 | Descriptive and Prospective Study of Sphincter Disorders in The Severe Traumatic Brain Injury Population Related Papers Related Patents Related Grants Related Experts View Highlight: Severe traumatic brain injury (TCI), defined by an initial GCS of ≤ 8 and/or admitted to a neurosurgical intensive care unit, are responsible for diffuse brain lesions that can lead to multiple deficits, including impairment of sphincter functions: bladder, rectal and sexual. Bladder-sphincter disorders are very common after a TBI. Urinary incontinence predominates, with a prevalence varying from 50 to 100% in the acute period following a TBI. The variability of the clinical data is explained by the heterogeneity of the populations studied (severity of TBI, duration of coma, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-02-02 |
| 219 | Prevalence, Severity, Risk Factors, and Prognostic Value of Hyponatremia in Patients With Traumatic Brain Injury : A Retrospective Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Hyponatremia (HN) is the most common electrolytic disorder in the traumatic brain injury (TBI) population, found in 17 to 51% of patients according to the series. Two etiologies predominate in the literature, the Syndrome of Inappropriate Anti Diuretic Hormone (SIADH) and the Cerebral Salt Waste Syndrome (CSW), but none has been precisely described in terms of epidemiology, risk factors or severity. Moreover, SIADH and CSH were often confused in previous works. The main goal of our study is to assess retrospectively prevalence, severity, time to onset, length, risk factors of HN in a large population of TBI patients, … |
JONATHAN CHARBIT; | 2022-02-01 |
| 220 | Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members. This research hopes to learn about the effects of art therapy on emotional expression and regulation in service members as well as the neurological systems at work. If a participant chooses to be in this study, … |
CHANDLER RHODES; | 2022-02-01 |
| 221 | A Prospective, Non-Randomized, Sequentially Enrolled, Multi-Center, Phase II Study to Evaluate The SENSE Device’s Ability to Detect and Monitor Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study population will consist of 3 mutually-exclusive sets of patients and subjects: – TBI patients with intracranial bleeding – TBI patients without intracranial bleeding – Control subjects with normal brain health. Research subjects between the ages of 22 to 50 will be enrolled. All TBI patients must have a diagnostic head CT scan within 24 hours of the injury. TBI patients without intracranial bleeding based on the CT scan must have a Glasgow Coma Scale (GCS) score at enrollment of ≤ 14. Total maximum duration of active monitoring with the device in this study is 48 hours with a clinical follow-up at day 7 after enrollment. |
JONATHAN RATCLIFF; | 2022-02-01 |
| 222 | Application of Circulating Extracellular Vesicles in Early Disease Assessment and Prognosis After Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to observe the relationship between the changes of circulating extracellular vesicles and disease development and outcome in patients with traumatic brain injury, and to find early serum markers and potential intervention targets for disease monitoring in patients with traumatic brain injury. In addition, explore the source of extracellular vesicles as much as possible to prepare for subsequent basic experiments. |
QING HU; | 2022-01-25 |
| 223 | Evaluation of Ultrasonography As A Screening Tool for Dysphagia in Patients With Stroke: Correlation With Videofluoroscopic Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Oropharyngeal dysphagia is commonly seen in patients with stroke. Clinical assessment may be used to evaluate dysphagia in patients with stroke however reliability of this method is controversial and videofluoroscopic study is still considered as gold standard. However, exposure to radiation, necessity for a experienced practitioner, an expensive device, and swallowing contrast agents are disadvantages of videofluoroscopy. Ultrasonography, on the other hand, is a cheap, noninvasive device which may demonstrate tongue and laryngeal movement dynamically. In this manner, this study aims to evaluate whether ultrasound can assess dysphagia in patients with hemiplegia accurately. |
DELAL ÖZTÜRK; | 2022-01-22 |
| 224 | Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The CONNECT-TBI Trial aims to develop safe, effective treatments for complex mTBI that improve cognitive functioning. Based on the compelling preliminary data generated by our study team, the objective of this study is to conduct a randomized, double-blinded, sham-controlled Phase II clinical trial of APT-3 combined with rTMS, HD-tDCS, or sham to treat cognitive control deficits in Veterans with complex mTBI and PPCS. At the Baseline Visit, participants will undergo demographic, neuropsychological, behavioral, and quality of life testing. They will also undergo structural MRI to permit modeling of their brain, resting/task-related fMRI to identify the CCN, … |
DAVIN KENNETH QUINN; | 2022-01-21 |
| 225 | Comparison of Constraint Induced Movement Therapy and Proprioceptive Neuromuscular Facilitation on Lower Limb Motor Function in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke, described as a neurological deficit caused by the interruption of cerebral blood flow, is one of the leading causes of mortality and morbidity throughout the world. It is the second most common medical condition and the major cause of disability in adults. Recovery following stroke revolves around the severity of sensory, motor, and cognitive impairments. Lower extremity impairment is one of the major post-stroke conditions which can cause difficulty in performing activities of daily living, gait abnormalities, increased risk of fall, … |
AYESHA AFRIDI; | 2022-01-15 |
| 226 | Interactive CBT for Headache And Relaxation Training (iCHART) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This mixed-methods pilot study aims to evaluate the feasibility, acceptability, and preliminary effectiveness of iCHART (Interactive CBT for Headache And Relaxation Training), an interactive voice response (IVR) based delivery of cognitive behavioral therapy for Veterans with post-traumatic headache. Participants will receive iCHART treatment through the IVR system over a period of 10 weeks, which will include an automated daily assessment of patient-reported outcomes, retrieval of fortnightly tailored feedback from a study therapist, and additional weekly one-way motivational enhancement messaging. Delivery of traditional evidence-based behavioral treatments for headache management through technology-based interventions, … |
AMY GRINBERG; | 2022-01-06 |
| 227 | Ultrasound-guided Stellate Ganglion Block Versus Nimodipine Infusion for Enhancement of Cerebral Blood Flow in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler |
KHALED MOHAMED ABDELAAL; | 2022-01-01 |
| 228 | A Randomized Controlled Trial of An Innovative In-home Rehabilitation Program for Persons With TBI and Their Families: Home-based Occupational-therapy and Management of The Environment (HOME for Us) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This purpose of this study is to evaluate an innovative rehabilitation intervention for persons with chronic TBI-related symptoms (1 year or more post injury) and their families. The primary study aims are to 1) test the intervention’s effects on patients’ community reintegration, quality of life, and ability to manage self-identified TBI problems at the completion of the intervention and 2) test the intervention’s effects on family caregivers’ depressive symptoms, burden, and met family needs at the completion of the intervention. Based on the person-environment fit framework, HOME (Home-based Occupational-therapy and Management of the Environment) for Us is a 4-month, … |
HELENE MORIARTY; | 2021-12-22 |
| 229 | Register Study: Implementation of Pharyngeal Electrostimulation Therapy for The Treatment of Acute Neurogenic Dysphagia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Neurogenic dysphagia occurs with disruption of neurological systems or processes involved in the execution of coordinated and safe swallowing. It is common in patients with neurological diseases, in particular in patients treated in Intensive Care Units (ICU) who are intubated (up to 62%) and / or tracheotomised (up to 83%). Dysphagia is one of the most common and most dangerous symptoms of many neurological diseases. In addition, neurogenic dysphagia can have a significant impact on quality of life, medication efficacy, and malnutrition. Dysphagia is currently treated conservatively on evidence-based exercises, … |
MICHAELA TRAPL-GRUNDSCHOBER; | 2021-12-15 |
| 230 | Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization’s (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention. |
DAVID DARROW; | 2021-12-15 |
| 231 | Brief Telehealth Cognitive Rehabilitation Following Mild Traumatic Brain Injury: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the United States, more than a million people sustain a mild traumatic brain injury (mTBI) every year. Although many recover fully, emerging literature suggests a high number of individuals report chronic, and functionally disabling, cognitive difficulties. Among Veterans, a nationwide survey found that more than 75% of 55,000 Veterans with a history of mTBI reported persistent moderate to severe levels of forgetfulness and poor concentration. Reduced cognitive functioning following mTBI contributes to significant functional impairment, including underemployment, relationship difficulties, and reduced community integration for years post injury. Despite the significant individual and societal impact, … |
KATHLEEN PAGULAYAN; | 2021-12-13 |
| 232 | Head and Intraocular Trauma Tool for The Identification of Mild Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rebion has developed a device, the Rebion trauma tool (referred to as the head and intraocular trauma tool, or HITT), that detects ocular fixation and alignment using a binocular retinal scan. Preliminary data obtained from hospitalized patients with a clinically-confirmed traumatic brain injury (TBI) and uninjured controls indicates that the device can detect changes in ocular fixation, alignment, and saccades that are related to brain injury. This study seeks to evaluate the ability of the Rebion trauma tool to assess perturbations in eye movements resulting from TBI. The study will enroll 100 TBI patients and 100 controls. |
DAMON R KUEHL; | 2021-12-01 |
| 233 | Role of Combined Therapy of Propranolol and Gabapentin in Paroxysmal Sympathetic Hyperactivity in Traumatic Brain Injury at Emergency Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Paroxysmal sympathetic hyperactivity (PSH) is a syndrome that comprises a series of signs and symptoms reflecting exacerbated sympathetic activity, including arterial hypertension, fever, tachycardia, generalized perspiration, anomalous motor activity (dystonia, muscle stiffness, extension), tachypnea, mechanical ventilator maladjustment, hypoxemia, hypercapnia, and hyperglycemia. PSH episodes can be intense and prolonged and can occur several times a day and all of these can lead to secondary brain damage and are the main causes of a poor prognosis. Paroxysmal sympathetic hyperactivity also induces a hypermetabolic state with hypercatabolism and inflammation and increases vulnerability to infections, sepsis, … |
ESSAMEDIN MAMDOUH NEGM; | 2021-12-01 |
| 234 | Effect of Early Memantine Administration on Outcome of Patients With Moderate to Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Effect of Early Memantine Administration on Outcome of Participents with Moderate to Severe Traumatic Brain Injury |
SHADY NEMR YOUSSEF; | 2021-11-26 |
| 235 | Analyzing The Neuroprotective Effect of Dexmedetomidine in Terms of Preserving Brain Functional Connectivity in Elderly Patients After Major Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Older patients are more prone to adverse cognitive outcomes such as postoperative delirium (POD) and postoperative cognitive dysfunction (POCD). Both conditions are associated with an increased risk of death, functional decline, and health care costs. The presence of pro-inflammatory cytokines in the central nervous system has detrimental effects on the regulation of neurotransmitter signaling in different areas of the brain, especially the hippocampus, … |
IGNACIO CORTINEZ; | 2021-11-16 |
| 236 | Imaging Lymphatic/CSF Drainage From The Head and Neck in Persons With Traumatic Brain Injury: Demonstration of Feasibility and Evaluation of Manual Therapy to Improve Drainage and Facilitate Cognitive Recovery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether a course of daily manual lymphatic drainage over the course of 5 days can improve lymphatic drainage function and cognitive outcomes and to determine whether single sessions of manual lymphatic drainage improves lymphatic drainage in moderate to severe traumatic brain injury (TBI) patients. |
EVA SEVICK; | 2021-11-15 |
| 237 | Symptom-Targeted Approach to Rehabilitation for Concussion: STAR-C PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Throughout the course of the wars in Iraq and Afghanistan, more than 250,000 service members sustained traumatic brain injuries, mostly characterized as mild traumatic brain injuries (mTBI) or concussions. While most with mTBI recover over days to weeks, a significant percentage continue to experience post-concussive symptoms such as headaches, cognitive difficulties, and dizziness for months to years. As a result, treatment of post-concussive symptoms after mTBI is of significant importance in the Department of Defense and Veterans healthcare systems. Several studies have shown that cognitive rehabilitation can be effective for individuals with mTBI, … |
BLESSEN EAPEN; | 2021-11-10 |
| 238 | Effects of Sensorimotor Stimulation Program With and Without Routine Physical Therapy on Balance and Cognitive Performance in Patients With Mild Traumatic Brain Injury: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study design: Randomized controlled trial Settings: Physiotherapy department of Allied hospital, Faisalabad Sample size: 27 in each group Control group receive: Routine physical therapy Experimental group receive: Routine physical therapy+ Sensorimotor stimulation |
HUMA WAQAR; | 2021-11-10 |
| 239 | Importance of Substance P in Intracranial Pressure Elevation Following Traumatic Brain Injury Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain (TBI) injury is the major cause of morbidity and mortality worldwide especially in population under 40 years of age and has a significant socioeconomic impact. TBI results from the head impacting with an object or from acceleration/deceleration forces that produce vigorous movement of the brain within the skull, with the resultant mechanical forces potentially damaging neurones and blood vessels and causing irreversible, primary brain injury. Primary injury leads to activation of cellular and molecular responses which lead to disruption of the blood-brain barrier causing the brain to swell. As the intracranial space is not expandable (i.e. is fixed), … |
ARUN GUPTA; | 2021-11-01 |
| 240 | Evaluation of Quantitative EEG During Art Therapy in Service Members With Co-Morbid Traumatic Brain Injury & Posttraumatic Stress Symptoms Related Papers Related Patents Related Grants Related Experts View Highlight: Service members and/or recently separated veterans with post traumatic stress symptoms and mild traumatic brain injury may participate in 8 sessions including 2 sessions including interviews and questionnaires as well as 6 sessions of art therapy. In the art therapy, participants will be provided with a blank paper mache mask template and invited to alter the mask however they wish using a variety of art materials. The therapist will use the art-making process and culminating product to aid in self-reflection, reframe negative thoughts and feelings, … |
WALTER REED NATIONAL MILITARY MEDICAL CENTER | 2021-10-30 |
| 241 | Imaging of Injury Mechanism and Interaction of Intestinal Bacteria in Children With Mild Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is the leading cause of disability in children and young adults. Children with moderate to severe TBI are typically at risk of poor functional outcome in terms of neurocognitive impairment and behavior problems. Neurocognitive impairments include deficits in attention and working memory, learning and memory, and executive functioning, whereas behavior problems include anxiety, depression and aggression. Neuroimaging techniques based on multi-modal magnetic resonance image (MRI) can detect the structural and functional brain abnormalities objectively and sensitively. Recent evidence indicates that even after mild TBI, … |
MING ZHANG; | 2021-10-25 |
| 242 | Evaluation of Safety and Efficacy of Glibenclamide in The Treatment of Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Brain edema is one of the main mechanisms of secondary brain injury and one factor in the prognosis of traumatic brain injury . The clinical study of glibenclamide in the treatment of brain edema after traumatic brain injury is designed to evaluate whether glibenclamide treatment can improve the blood NSE and S100β levels of severe traumatic brain injury , so order to explore the efficacy and adverse effects of this drug in the treatment of traumatic brain injury . |
GUANGZHI SHI; | 2021-10-22 |
| 243 | Assessment of The Effects of Early Proprioceptive Stimulations in Patients With Severe Traumatic Brain Injury : A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe traumatic brain injury (TBI) is a serious condition, common in young adults. It leads to sensorimotor and cognitive sequelae that hinder social reintegration. Neuronal plasticity must be used quickly before natural recovery impedes neuronal regrowth. In this respect, stopping sedation as soon as possible and early mobilization, even if the patients are unconscious, are recognized as useful measures to promote recovery. However, at the early stage, the environment of the ICU and the acute condition of the patients limit the rehabilitation possibilities. In such a context, functional proprioceptive stimulations (Vibramoov™ system, Techno Concept, … |
BERNARD VIGUE; | 2021-10-20 |
| 244 | Improvement in Sleep Symptomatology and Neurocognitive Function Using Photobiomodulation in Post-Concussion Patients With Non-Apneic Sleep Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The emphasis on this study is to review the use of PBMT as a potential treatment modality to improve both sleep symptoms and consequent neuropsychological functions affected by sleep disturbances in a cohort of post-mTBI patients with sleep issues not secondary to sleep apnea. |
MICHAEL ZITNEY; | 2021-10-20 |
| 245 | Nutritional Treatment for The Amelioration of Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To test the feasibility of administering a commercially available neurotrophic oral nutritional supplement (ONS) for adult patients with acute traumatic brain injury at the Royal London Hospital. |
CHRIS UFF; | 2021-10-14 |
| 246 | Randomized, Single-blind Clinical Trial to Evaluate The Efficacy of Cognitive Rehabilitation Using Inmersive Virtual Reality and Computer-based Cognitive Stimulation Versus Music Therapy on Cognitive Impairment Associated With Movement Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild cognitive impairment associated with movement disorders occurs in up to one third of patients in early stages of the disease, and confers an increased risk of developing dementia. Non-pharmacological interventions to improve cognition have so far been based on computer-based cognitive stimulation and rehabilitation programs. These interventions base their mechanism of action on neuroplasticity and how improvements in cognitive function will generalize to functional improvement. Despite having shown certain indicators of efficacy in previous exploratory studies and clinical trials, cognitive rehabilitation continues to show insufficient evidence and requires further study. To date, … |
FUNDACIÓ INSTITUT DE RECERCA DE L’HOSPITAL DE LA SANTA CREU I SANT PAU | 2021-10-13 |
| 247 | Long-term Follow-up in Severe Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The underlying pathophysiology following traumatic brain injury (TBI) in how different neurodegenerative conditions are developed are still unknown. Different neuroinflammatory and neurodegenerative pathways have been suggested. The goal of this study is to follow-up patients that have been treated for TBI at the neurosurgical department about 10-15 years after their initial injury, in order to analyze fluid biomarkers of inflammation, injury and degeneration and associate these with structural imaging and long-term functional outcome. The investigators aim to invite about 100 patients back and perform advanced magnetic resonance imaging protocols, sample cerebrospinal fluid and blood for different bio- and inflammatory markers, … |
ERIC THELIN; | 2021-10-01 |
| 248 | Cerebrovascular Reactivity and Oxygen Metabolism As Markers of Neurodegeneration After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This grant award entitled, Cerebrovascular Reactivity and Oxygen Metabolism as Markers for Neurodegeneration after Traumatic Brain Injury (hereafter, Neurovascular Study), aims to determine if neurovascular contributors to neurodegeneration can serve as markers of the emergence or progression of degenerative processes after traumatic brain injury in middle-aged and older adults. |
JULIE C. CHAPMAN; | 2021-10-01 |
| 249 | Aerosolized Endotracheal Lidocaine to Avoid Intracranial Pressure Spikes in Patients With Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the effectiveness of nebulized lidocaine before Endotracheal suctioning (ETS) compared to instilled lidocaine and the effectiveness of aerosolized lidocaine versus instilled normal saline before ETS in attenuating the increase of intracranial pressure (ICP) in severe head injured children and to evaluate the feasibility of a trial involving instilled lidocaine and aerosolized lidocaine for the management of ETS and to evaluate the safety of nebulized lidocaine in traumatic brain injury (TBI) compared to instilled lidocaine and instilled sodium chloride (NS). |
SHEIKH SOHAIL AHMED; | 2021-10-01 |
| 250 | TTI-0102, A Cysteamine Precursor for Mild to Moderate TBI: Dosing and Feasibility Study Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is a signature wound of the recent wars. How chronic TBI symptoms develop after a mild brain injury is not fully understood, but it is now thought that injury results in damage that reduces brain energy production, increases inflammation, and results in a leaky blood-brain barrier. Difficulties in daily function may persist in areas such as thinking (e.g., attention, learning, memory, planning, and problem-solving), pain (e.g., headache) and behavior (e.g., sleep, posttraumatic stress disorder, depression). No medications for TBI have been developed, … |
ELIZABETH W. TWAMLEY; | 2021-10-01 |
| 251 | Evaluation of Intracranial Pressure Time Dose By The New Integra CereLink ICP Monitor PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The new Integra CereLink ICP monitor integrate the possibility of recording and displaying continuously the AUC (Pressure Time Dose, PTD) and other ICP derived variables and provide the possibility of evaluating the utility of this information at the bedside. It offers the opportunity to test in a standardized way the clinical value of the PTD computation in this setting. Therefore, this study aims to test clinically if PTD recorded continuously is associated to patients’ outcome and to identify a threshold of PTD associated with the transition from good to negative outcomes. |
GIUSEPPE CITERIO; | 2021-09-27 |
| 252 | Estimating Highest Capacity Performance During Evaluation of Walking for Individuals With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) due to trauma and/or neurologic disease is a leading cause of long-term disability in the United States. The loss of balance for people with a traumatic brain injury can have a large effect on their walking abilities and this can come with a number of challenges. There is a greater risk of falling after being discharged from the hospital. In addition, people are more likely to become sedentary after TBI, which leads to the loss of muscle strength. To help provide the best care, clinicians need accurate measurements when people begin their therapy, … |
DAVID BROWN; | 2021-09-22 |
| 253 | Incidence Of Morbidity And Mortality After Isolated Traumatic Brain Injury In Adult Neuro-intensive Care Unit In Minia University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tracking post-traumatic brain injury sequale |
MINA MAHER; | 2021-09-15 |
| 254 | Brain Injury and Ketamine: A Prospective, Randomized Controlled Double Blind Clinical Trial to Study The Effects of Ketamine on Sedative Sparing and Intracranial Pressure in Traumatic Brain Injury Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Although, in the past years, an increasing use of ketamine in Traumatic Brain injury (TBI) has been reported as an adjunct to other sedatives, there is no evidence from randomized clinical trial to support this practice. The BIKe (Brain Injury and Ketamine) study is a double-blind placebo controlled randomized multicenter clinical trial to examine the safety and feasibility of using ketamine as an adjunct to a standard sedative strategy in TBI patients. |
GEERT MEYFROIDT; | 2021-09-06 |
| 255 | Virtual Reality-based Rehabilitation for Pediatric TBI (R00 Phase) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Childhood traumatic brain injury (TBI) poses significant impairment in children’s executive functions (EFs) for moderate to severe injuries, yet interventions specifically designed for children’s EF rehabilitation post-TBI and rigorous clinical trials to establish the efficacy of such interventions remain unavailable. In this study, the investigators will conduct a randomized clinical trial to evaluate the efficacy of a novel virtual reality (VR)-based training program for EF rehabilitation for childhood TBI. |
JIABIN SHEN; | 2021-09-03 |
| 256 | Effectiveness of Combined Attention and Metacognitive-strategy Training Approaches to Cognitive Impairment in Moderate-to-severe TBI Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to develop a method to improve thinking difficulties in individuals who have experienced a traumatic brain injury and report experiencing difficulties in attention and concentration. This study aims to understand how cognitive rehabilitation of attention difficulties affects brain activity. |
UNIVERSITY OF FLORIDA | 2021-09-01 |
| 257 | Neural Markers of Static & Dynamic Balance Before & After Yoga in Adults With Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The feasibility study is designed to assess the feasibility of conducting a group yoga intervention and acquiring neuroimaging data in adults with chronic brain injury. |
JACLYN A STEPHENS; | 2021-08-30 |
| 258 | A Randomized Trial Evaluating The Efficacy of Oral Magnesium in Symptomatic Reduction of Acute Concussion in Adolescents Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized trial will compare the clinical efficacy of adding oral magnesium oxide to acetaminophen and ondansetron in the treatment of adolescents presenting within 48 hours of a mild traumatic brain injury using the Post-Concussion Symptom Severity Score Index. |
CHRIS TRIGGER; | 2021-08-30 |
| 259 | Multicenter Observational Study on Practice of Ventilation in Brain Injured Patients PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale Several experimental and clinical studies have shown how brain injury can cause secondary lung injury. Lung injury could be due either to mechanical ventilation- often necessary in brain injured patients- or to inflammatory response that follows primary acute brain injury. The concept of ‘Protective lung ventilation’ has shown to reduce morbidity and mortality of intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS) but seems also to have a beneficial effect on patients with healthy lungs and in the perioperative settings. However, … |
CHIARA ROBBA; | 2021-08-23 |
| 260 | A Randomized Double-blind, Placebo-controlled, Multi-center Trial to Investigate The Efficacy and Safety of NeuroAiD II™ (MLC901) to Improve Cognitive Functioning in Non-surgical Mild Traumatic Brain Injury Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Randomized Double-blind, Placebo-controlled, Multi-center Trial to determine the efficacy of NeuroAiD II™ (MLC901) in improvement of cognitive functioning of adult patients with long-term cognitive impairment following mild traumatic brain injury (mTBI) and to assess safety of NeuroAiD™ (MLC901) in these patients. |
VERA GRIGORYEVA; | 2021-08-23 |
| 261 | Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute brain injury due to traumatic brain injury (TBI), intracerebral haemorrhage (ICH), and aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, in part due to the development of secondary brain injury. The mechanisms behind secondary brain injury are incompletely understood, but oxidative/nitrosative stress and disturbances in the metabolism of the vasodilator nitric oxide (NO) are believed to be involved. The aim of the present study is to characterise systemic changes in markers of oxidative/nitrosative stress and NO metabolism in the early phase after acute brain injury, and to examine their relationship to clinical course, neurological outcome, and mortality. |
ANTON LUND; | 2021-08-18 |
| 262 | Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive symptoms. Caregivers frequently report minimal support or training to prepare them for their new role. Periods of care transitions, such as ICU discharge, are most difficult. The majority (93%) of previously developed caregiver and caregiver/survivor dyad interventions after msTBI focus on providing information or practical skills to either survivors, or to long-term caregivers (\>6 months post injury), rather than education, support, … |
NATALIE KREITZER; | 2021-08-16 |
| 263 | Non-invasive Vagal Neurostimulation (nVNS) to Mitigate Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress and Acute Lung Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, randomized, two-arm, controlled 30-day investigational pilot trial using the gammaCore Sapphire S non-invasive vagus nerve stimulation (nVNS) device + standard of care (SOC) in newly-hospitalized patients with mild-to-moderate traumatic brain injury (TBI) to prevent the progression towards immunokine storms, systemic inflammatory response syndrome (SIRS), severe respiratory distress, and requirement for invasive mechanical ventilation, and death, when compared to SOC alone (the control arm). |
BOYLE CHENG; | 2021-08-04 |
| 264 | Head and Intraocular Trauma Tool (HITT) for The Identification of Mild Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rebion has developed a device, the Rebion trauma tool (referred to as the head and intraocular trauma tool, or HITT), that detects ocular fixation and alignment using a binocular retinal scan. Preliminary data obtained from hospitalized patients with a clinically-confirmed traumatic brain injury (TBI) and uninjured controls indicates that the device can detect changes in ocular fixation, alignment, and saccades that are related to brain injury. This study seeks to evaluate the ability of the Rebion trauma tool to assess perturbations in eye movements resulting from TBI. The study will enroll 100 TBI patients and 100 controls. |
RAMON DIAZ-ARRASTIA; | 2021-08-01 |
| 265 | Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will examine if computerized cognitive remediation will improve working memory and attention in 25 adults with moderate to severe brain injury and compared their cognitive performance to the control group of 25 adults with moderate to severe brain injury. The control group will train on computerized tasks of social awareness. Participants in both groups will be assessed prior to training and immediately post-training and one month-post training. |
GERALD VOELBEL; | 2021-08-01 |
| 266 | Treatment of Verbal Retrieval Deficits in Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in military veteran participants with histories of traumatic brain injuries. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, … |
JOHN HART; | 2021-08-01 |
| 267 | Traumatic Brain Injury and The Gut Microbiome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine whether administration of a prebiotic, inulin, can improve the symptom complex associated with traumatic brain injury and whether inulin administration can alter the bacteria that live in the gut. |
BRENT MASEL; | 2021-07-28 |
| 268 | Interest of The 7 Tesla MRI in The Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We aimed to conduct a prospective longitudinal interventionnal monocentric study to assess the ability of seven tesla MRI to detect diffuses axonal lesions in patients presenting a post concussional syndrom (PCS) at seven days about a mild traumatic brain injury (MTBI). Our first objective was to evaluate the diagnostic performance of seven tesla MRI runned at seven days after MTBI among patients presenting a PCS. |
POITIERS UNIVERSITY HOSPITAL | 2021-07-26 |
| 269 | The Effect of Lumbar Cerebrospinal Fluid Drainage on The Neurologic Outcome Improvement in Out of Hospital Cardiac Arrest Patients Underwent Targeted Temperature Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim: The investigators aim to evaluate the effect of lumbar cerebrospinal fluid (CSF) drainage on neurologic outcome in post-cardiac arrest (CA) patients treated with target temperature management (TTM). Methods: This is a prospective single-center study conducted from May 2020 to November 2021 on patients who have been treated with TTM following CA. The propensity score matching is proceeded between the lumbar CSF drainage and non-lumbar CSF drainage groups. The good outcome group is defined as a Glasgow-Pittsburgh cerebral performance categories (CPC) scale 1 or 2, … |
CHUNGNAM NATIONAL UNIVERSITY HOSPITAL | 2021-07-05 |
| 270 | Minor Traumatic Brain Injury : MRI Examination of Consequences and Social Insertion PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Minor traumatic brain injury (mTBI) (Glasgow Coma Scale 13 to 15) represent 70 to 90% of traumatic brain injury. Different disorders may occur after a traumatic minor brain injury (somatic, cognitive or affective) within 2 weeks. For 10 to 20% these symptoms are persistent and are part of post-concussion syndrome. Today a small amount of tools to predict this syndrome are available. Cerebral CT scan, a routine test for mTBI, isn’t relevant to predict the post concussion syndrome. In order to improve understanding of the evolution toward this complication, … |
UNIVERSITY HOSPITAL GRENOBLE | 2021-07-02 |
| 271 | Concordance Between Ultra-low Dose (ULD) and Conventional Standard Dose CT Scans in The Search for Traumatic Brain Injury at The Emergency Department Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research is to evaluate the diagnostic concordance of ultra low-dose and standard dose reconstructed computed tomography acquisitions using the ADMIRE algorithm to search for intracranial lesions – both hemorrhagic and bone lesions – in trauma patients at the emergency department. The study will also evaluate the diagnostic performance of the two protocols, as well as the speed of image reading. For the first time, … |
NICOLAS MENJEOT DE CHAMPFLEUR; | 2021-06-26 |
| 272 | Internet Delivered Cognitive Behavioural Therapy for Persons With Mild Traumatic Brain Injury: Pilot Phase 2 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Individuals with neurological conditions (stemming from brain injury or stroke) can experience high levels of emotional distress leading to decreased quality of life and increased health care costs. Though mental health problems are prevalent and disabling, they often go untreated for various reasons, such as access to specialized care, rural and remote location, lack of time, … |
SWATI MEHTA; | 2021-06-21 |
| 273 | Imaging [18F]PI-2620 and [18F]Florbetaben in Military Service Members With Blast Related Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this interdisciplinary study is to develop an understanding of the molecular imaging features of blast-related mild traumatic brain injury (mTBI) in military personnel, while helping to establish assessment tools that may be of use in diagnosis, determining prognosis, and in future therapeutic clinical trials. Additionally, the objective is to evaluate feasibility of [18F]PI-2620 in the assessment TBI. |
LIFE MOLECULAR IMAGING SA | 2021-06-07 |
| 274 | Transcranial Doppler As An Early Predictor of Neurological Outcome in Mild and Moderate Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Utility of transcranial Doppler as an Early Predictor of Neurological deterioration in Mild and Moderate Traumatic Brain Injury |
MAI KAMAL; | 2021-06-03 |
| 275 | A Multi-center Observational Cohort Study of Management of Moderate Traumatic Brain Injury With or Without Intracranial Pressure Monitoring in Patients With Moderate Traumatic Brain Injury in China PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives The primary focus for scientific investigation is to conduct a multi-center observational study to determine if intracranial pressure (ICP) monitoring to direct treatment of patients with moderate traumatic brain injury (TBI) improves medical practice and patient outcomes in China. Design and Outcomes This is a prospective observational cohort multi-center study with blinded evaluation of outcome. It is a 2-group design. Neurologic outcome is evaluated by extended Glasgow outcome score(GOSE) at 6 months. Interventions and Duration This is an observational study. The decision of intracranial pressure monitoring is made by the relatives of patient. Management of all patients will be consistent with protocols presently being used in the study hospitals. For patients who received ICP monitoring, the management will also be based specifically on the presence of intracranial hypertension. Each patient will be evaluated at 6 months post injury on neurological outcomes. Sample Size and Population 832 patients with moderate traumatic brain injury will be collected on this study. |
TANG DU HOSPITAL | 2021-06-01 |
| 276 | Randomized Placebo Controlled Trial of Intravenous N-Acetylcysteine for The Treatment of Acute Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a major cause of death and long-term disability in the developed world. While t-PA and mechanical thrombectomy have been shown to decrease disability in properly selected patients, many patients are left with lifelong symptoms. There are currently limited options available for patients who are not candidates for treatment with t-PA and/or mechanical thrombectomy. N-Acetylcysteine (NAC) is an FDA approved antioxidant and anti-inflammatory agent that has been used safely for many years in the treatment of acetaminophen overdose. In studies, … |
DAVID TANEN; | 2021-06-01 |
| 277 | Supplementation With Amino Acid Rehabilitative Therapy in TBI (SmART-TBI): A Randomized Placebo-Controlled Trial to Improve Sleep PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The most persistent and disabling postconcussive symptoms following mild traumatic brain injury (mTBI) are sleep disturbances and cognitive dysfunction, with few tractable interventions currently available. Here, a novel therapy will be tested consisting of dietary supplementation with branched chain amino acids (BCAA), based on the study team’s previous preclinical work showing restoration of glutamate neurotransmitter balance in sleep and memory circuits. Supplementation with Amino acid Rehabilitative Therapy in TBI (SmART-TBI) is a randomized, placebo-controlled, double-blinded, exploratory clinical trial of BCAA intended to establish the feasibility, acceptability, … |
MIRANDA M LIM; | 2021-06-01 |
| 278 | Vitamin B12 Vs B3 for Nerve Regeneration and Functional Recovery After Pediatric Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A traumatic brain injury (TBI) is among the most frequent reasons for neurological impairment in young people. The investigators investigated whether vitamin B12 vs B3 therapy could reduce the severity of traumatic brain injury (TBI) due to their positive effects on axon regrowth following nerve damage. The method utilized was a series of non-random samples. With a 95% confidence interval and a 5% margin of error, … |
HASSAN MUMTAZ; | 2021-06-01 |
| 279 | Effect of Early Bronchoalveolar Lavage on Severity of Ventilator Associated Pneumonia Assessed Through Clinical Pulmonary Infection Score on The Patients of Traumatic Brain Injury in Neurocritical Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe traumatic brain injury (STBI) is a leading cause of disability, mortality, and economic burden worldwide. The impact of severe traumatic brain injury (STBI) on the economy of developing countries like Pakistan is distressing. Pakistan has a large proportion of the young adult population in the World. Motorbike is the most common locomotive vehicle. These young ones are in the economically productive part of their lives. Their loss is an economical set back not only for their families but also for the Nation. Patients with STBI need standardized management in Neuro-critical care unit (NCCU). Although the setup and maintenance cost of an effective NCCU is one of the major burden on the budget of any public sector hospital, but the young survivor in turn can be productive for the Nation. During mechanical ventilation, severe traumatic brain injury patients frequently develop ventilator-associated pneumonia (VAP). Ventilator-associated pneumonia can be evaluated using Clinical pulmonary infection score (CPIS). CPIS is considered as an important clinical indicator of pneumonia in NCCU. Bronchoalveolar Lavage (BAL) is a minimally invasive procedure done with instillation of normal saline into subsegments of the lung followed by suction and collection of the instilled fluid for analysis with flexible bronchoscope. Patients with moderate and severe traumatic brain injury usually present with altered conscious level, and most of them already have aspiration of vomitus, debris and secretions which increase the risk of VAP in them. Bronchoalveolar lavage can be helpful in preventing this dreadful VAP by clearing the airways. The aim of this study is to find out the effect of early Bronchoalveolar Lavage on severity of development of VAP assessed through clinical pulmonary infection score (CPIS) in TBI patients. |
NAZIR AHMED; | 2021-06-01 |
| 280 | The Effectiveness and Underlying Mechanism of A Wellbeing Program for Traumatic Brain Injury – A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) patients face notable impairments which lead to reduced performance and regulation of daily and overall functioning. There are a number of interventions made to combat these qualms; however, such interventions have historically been therapeutically demanding, which limits their practical benefit. An online therapeutic intervention can provide a cost-effective approach that can be particularly well-suited to the needs and limitations of TBI. It focuses both on developing awareness and attention, which are often impaired, … |
JEAN LENGENFELDER; | 2021-06-01 |
| 281 | Feasibility of A Combined Neuromodulation and Yoga Intervention for Veterans With Mild Traumatic Brain Injury and Chronic Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this VA SPiRE application are to develop a combined neuromodulation and yoga (iTBS+yoga) intervention for Veterans with mild traumatic brain injury (mTBI) and chronic pain, assess the intervention’s feasibility and acceptability, and to gather preliminary clinical outcome data on quality of life, function and pain that will guide future studies. This SPiRE project will directly benefit Veterans and VA Services by developing a new, … |
AMY A HERROLD; | 2021-06-01 |
| 282 | TRACK-TBI Precision Medicine Phase 2-Option I PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being conducted to validate early and ultra-early blood-based and novel imaging biomarkers of Diffuse Axonal Injury (DAI), Microvascular Injury (MVI), and neuroinflammation that may serve as predictive and pharmacodynamic biomarkers in a new cohort of moderate-severe TRACK-TBI subjects. The study team will enroll a cohort of moderate to severe TBI subjects (N=50), stratified according to VA/DoD criteria for these injury severities through the existing TRACK-TBI network sites to obtain novel advanced neuroimaging and more frequent biomarker sampling. Subjects will be assessed over 3 months. |
MIKE MCCREA; | 2021-06-01 |
| 283 | Treatment of Spontaneous Hyperventilation in Severe Traumatic Brain Injury Patients: The Efficiency and Safety of Remifentanil Infusion and Its Impact on Cerebral Blood Flow PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Spontaneous hyperventilation is common in severe traumatic brain injury patients and correlates closely with poor outcomes. How to treat this pathological condition remain unsolved. Remifentanil is a frequently used short-acting opioid, has the potent side-effect of dose-dependent respiratory inhibition. Specifically, it prolongs the expiratory time only and does not influence the respiratory drive. Among the safety range, the investigators will determine an ideal dose of remifentanil to maintain PaCO2 between 35 to 45 mmHg. The investigators will monitor the cerebral blood flow of the middle cerebral artery and the internal carotid artery to validate cerebral perfusion improvement. |
JIAN-XIN ZHOU; | 2021-06-01 |
| 284 | Cognitive-based Rehabilitation Platform of Hand Grasp After Spinal Cord Injury Using Virtual Reality and Instrumented Wearables PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rehabilitation of functional movements after spinal cord injury (SCI) requires commitment and engagement to the processes of physical therapy. Outcomes may be improved by techniques that strengthen cognitive connections between users and physical therapy exercises. The investigators will investigate combinations of virtual reality and innovative wearable technology to accelerate rehabilitation of hand grasp and reach. These devices use multi-sensory feedback to enhance the sense of agency, or feelings of control, and better train movements during physical rehabilitation exercises. The investigators will measure the effect of these devices on improving the speed, efficiency, … |
NOAM Y. HAREL; | 2021-05-17 |
| 285 | Translation and Cross Cultural Validation on Modified Fatigue Impact Scale in Urdu Language PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cross cultural analytical study to translate Modified fatigue impact scale MFIS) in Urdu language. Along with the translated version by evaluating its validity and reliability among the patients of traumatic brain injury. No such study has been previously conducted in Pakistan which translate this scale in Urdu and follows the proper cross- culture adaptation.Condition or disease: Traumatic brain injury. Convenient sampling technique would be used. |
TEHREEM MUKHTAR; | 2021-05-15 |
| 286 | Interdisciplinary Intervention for Patients With Post-concussion Symptoms 3-6 Months Post-injury (GAIN 2.0). A Stepped Wedge Cluster Randomised Trial: Effect on Symptoms, Participation in Daily Activities, and Labour Market Attachment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study tests the promising results of a previous study (GAIN 1.0) in a larger RCT (GAIN 2.0) which takes place in the municipalities of Central Denmark Region where citizens live their daily lives and whose health- and social care systems support citizens who experience persisting PCS. |
JØRGEN F NIELSEN; | 2021-05-12 |
| 287 | Endocrine, Metabolic and Microbiome Influence on The Post-COVID Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is characterize the endocrine, metabolic and microbiomes of patients with post-COVID syndrome and patients that have recovered from COVID without lingering symptoms. |
RANDALL URBAN; | 2021-05-12 |
| 288 | Safety and Efficacy of MLC901 (NeuroAiD Ii) in Patients With Moderate TBI: A Randomized Double Blind Placebo Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study wants to evaluate whether MLC901 will help improve the condition of adult patients with moderate traumatic brain injury. |
ANNABELL CHUA; | 2021-05-01 |
| 289 | Multimodal Screening and Diagnostic Approaches to Brain Trauma in Performance Populations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to explore possible solutions needed for valid and reliable multidimensional objective assessment tools to use in screening performers for concussions, as well as, for use postinjury assessment and management of the mild traumatic brain injury, regardless of time since injury occurrence. These mobile tools would also enable clinicians to test the effectiveness of the interventions used post-concussion, prior to fully releasing the performer back into full performance/active status. |
CLEA TUCKER; | 2021-05-01 |
| 290 | Comparison Between The Neuroprotective Effect of Vitamin D Versus Dexmedetomidine in Patients With Traumatic Brain Injury Using Interleukin 6 As Inflammatory Marker PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: in this study the investigators compare between the neuroprotective effect of vitamin d versus dexmedetomidine in patients with traumatic brain injury using interleukin 6 as inflammatory biomarker |
ASMAA ELHELW; | 2021-04-25 |
| 291 | Intramuscular Tranexamic Acid for The Treatment of Symptomatic Mild Traumatic Brain Injury in Older Adults: A Randomised, Double-blind, Placebo-controlled Trial PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Tranexamic acid (TXA) reduces head injury deaths. The CRASH-4 trial aims to assess the effects of early intramuscular TXA on intracranial haemorrhage, disability, death, and dementia in older adults with symptomatic mild head injury |
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE | 2021-04-18 |
| 292 | Wellness and Quality of Life Perceptions of People With Traumatic Brain Injury Receiving Post-acute Telerehabilitation Versus Clinic-based Services PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Telerehabilitation is a service delivery method that has grown substantially in recent years. It has both advantages and disadvantages in comparison to clinic-based services. For example, telerehabilitation is advantageous for people residing in locations in which specialized rehabilitation services are scarce; however, it has the disadvantage of being dependent on reliable internet connections that are not available in all locations. Also, some people prefer the privacy afforded by receiving treatment in their home, … |
KAREN HUX; | 2021-04-16 |
| 293 | Effects of Vitamin D Supplementation on Depression and Inflammatory Markers in Adolescent and Youth With Major Depression and Vitamin D-deficiency: A Partially Randomized Preference Trial in Taiwan PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current study is designed as a prospective partially randomized patient preference (PRPP) trial and recruit psychiatric outpatients or inpatients. Participants who agree to receive randomization will be randomly assigned into a supplementation or placebo group, after stratification for pre-intervention vitamin D status (12-20 ng/mL or <12 ng/mL) and depression status (HDRS-17 ≥ 17 or < 17). Participants who decline randomization but agree to receive follow-up in the observational cohort choose their preferred method (either 4800 IU vitamin D3 per day, or usual care without supplementation). Severity of depression, any change of medication, ... |
SHEN-ING LIU; | 2021-04-12 |
| 294 | Outcomes of Autologous Bone Marrow-derived Mononuclear Cell Transplantation in The Management of Neurological Sequelae After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and efficacy of autologous bone marrow-derived mononuclear cell transplantation in the management of neurological sequelae after traumatic brain injury |
VINMEC RESEARCH INSTITUTE OF STEM CELL AND GENE TECHNOLOGY | 2021-04-01 |
| 295 | The Application and Modification of An Emotional Processing Intervention for Children With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigating an emotional processing program, that is modified for use with children, is effective for children with a traumatic brain injury (TBI). |
JEAN LENGENFELDER; | 2021-04-01 |
| 296 | Evaluation of The Effects of Vibration and Kinesiology Tape Applications Applied to The Affected Side Forearm Extensor Muscles on Hand Skills in Children With Hemiplegic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to evaluate the effects of vibration and kinesiology tape applications applied to the affected side forearm extensor muscles on dexterity in children with hemiplegic cerebral palsy. |
BEYZANUR DIKMEN; | 2021-04-01 |
| 297 | Beta Blocker Effects on Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma to evaluate effects of beta blocker on patients with TBI. |
MOSTAFA SAIEED FAHIM MANSOUR; | 2021-04-01 |
| 298 | Optimization of Cerebral Oximetry And Avoid Cerebral Deoxygenation In Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe traumatic brain injury with a decrease in cerebral oximetry is associated with multiple impaired systemic microcirculations, more morbidities, and a higher mortality rate. When using the brain as an index organ, interventions to improve brain oxygen delivery may have systemic benefits for these patients. |
PANU BOONTOTERM; | 2021-04-01 |
| 299 | Efficacy of Repetitive Transcranial Magnetic Stimulation (r-TMS) Combined With Visual Scanning Treatment on Cognitive-behavioral Symptoms of Unilateral Spatial Neglect in Patients With Traumatic Brain Injury: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized Controlled Trial (RCT) aiming at assessing the efficacy of a novel rehabilitation protocol, based on repetitive transcranial magnetic stimulation (r- TMS) in combination with a conventional cognitive treatment (CCT). The protocol will be statistically compared to the same CTT administered without the r-TMS in a sample of traumatic brain injury patients (age between 18 and 80 years) with left hemispatial Neglect. |
FRANCESCO DI GREGORIO; | 2021-03-30 |
| 300 | Effect of Progressive Early Mobilization on Functional Recovery in Patients With Moderate-severe Traumatic Brain Injury: A Single-blind, Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goals of this proposed research are (1) to investigate the feasibility of a structured and interdisciplinary progressive EM protocol for critically ill patients with trauma in a trauma ICU and (2) to determine the effectiveness of the progressive EM protocol, which is designed for implementation with trauma patients. |
HUNG-JUI CHUANG; | 2021-03-30 |
| 301 | Real Time Vital Sign Assessment to Predict Neurological Decline After Traumatic Brain Injury (RAPID-TBI) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look to validate predictive algorithms developed in a previous study where we collected relevant data from trauma registry and after using advanced signal-processing and machine-learning, determined prediction scores regarding neuroworsening and other outcomes following traumatic brain injury. |
NEERAJ BADJATIA; | 2021-03-29 |
| 302 | Phase 1, Randomized, Double-blind, Placebo-controlled, Multiple-ascending-dose Trial to Evaluate The Safety, Tolerability, Immunogenicity, and Pharmacokinetics of Intravenous PNT001 in Hospitalized Patients With Traumatic Brain Injury (TBI) Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1, multi-center, randomized, double-blind, placebo-controlled, multiple-ascending- dose trial to evaluate the safety, tolerability, immunogenicity, and pharmacokinetics of intravenous PNT001 in hospitalized patients with traumatic brain injury. |
PINTEON THERAPEUTICS | 2021-03-29 |
| 303 | Characterization of Fatigue in Military Personnel With Traumatic Brain Injuries Related Papers Related Patents Related Grants Related Experts View Highlight: Background: People who have had a traumatic brain injury (TBI) often experience fatigue. Fatigue is the feeling tired all the time. Researchers want to learn more about how TBI and fatigue are related. Objective: To better understand fatigue after TBI in active duty military and veterans. Eligibility: Active duty service members or veterans ages 25-40 who have sustained at least 1 TBI more than 6 months but less than 5 years ago Design: Participants will be screened with: – Medical history – Physical exam – … |
JESSICA GILL; | 2021-03-19 |
| 304 | Wideband Tympanometry for Monitoring Intracranial Pressure in Adult Patients in Intensive Care, Operated on for An Intracranial Lesion After Traumatic Brain Injury, or With Intracranial Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intracranial pressure is usually measured by invasive methods requiring an intracranial sensor. There is no non-invasive monitoring method recognized as a gold standard. Tympanometry would make it feasible to evaluate intracranial pressure through sensitive and specific changes in the energy absorbance of the middle ear. It could represent a non-invasive method of monitoring intracranial pressure. This is a prospective monocentric longitudinal study. All adult patients in intensive care for head trauma, intracranial hypertension, or after cranial surgery and requiring invasive monitoring of ICP will be included after their non-opposition has been collected. In a group of 10 controls, … |
CENTRE HOSPITALIER UNIVERSITAIRE DIJON | 2021-03-04 |
| 305 | Validity and Reliability of Turkish Version of The Working Memory Questionnaire PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to determine the Turkish validity and reliability of ”The Working Memory Questionnaire” developed by Dr. Vallat-Azouvi. |
LÜTFIYE AKKURT; | 2021-03-03 |
| 306 | Long Term Results of Psychoeducation and Cognitive Rehabilitation After Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild traumatic brain injury (mTBI) accounts for 70-90% of brain injuries, with 600 cases of mTBI per 100 000 people in the united states, but only 100-300 mTBI patients per 100 000 people receive hospital-based care. Symptoms reported immediately after injury tend to diminish over the following 10 days and are generally resolved by 3 months. However, in 15-25% of cases , problems persist, and may even worsen, at 3 months. Physical, emotional, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2021-03-02 |
| 307 | Stockholm Score of Lesion Development on Computerized Tomography Following Mild Traumatic Brain Injury PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild traumatic brain injury (mTBI) is one of the most common reasons behind emergency department (ED) visits. A small portion of mTBI patients will develop an intracranial lesion that might require neurosurgical intervention. Several guidelines have been developed to help direct these patients for head Computerized Tomography (CT) scanning, but they lack specificity, mainly focus on ruling out lesions, and do not estimate the risk of lesion development. The aim of this retrospective observational study is to create a risk stratification score that predicts the likelihood of intracranial lesion development, lesion progression, … |
ERIC THELIN; | 2021-03-01 |
| 308 | Evaluation and Application of Ultra Low-Resolution Pressure Reactivity Index in Moderate or Severe Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The pressure reactivity index (PRx) has emerged as a surrogate method for the continuous bedside estimation of global cerebral autoregulation and a significant predictor of unfavorable outcome. However, calculations require continuous, high-resolution monitoring and are currently limited to specialized ICU with dedicated software. To overcome this problem, new indices calculated using one-minute average data, instead of 10 seconds average data as performed by the PRx, … |
PAOLO GRITTI; | 2021-03-01 |
| 309 | Incidence and Associated Risk Factors of Augmented Renal Clearance (ARC) in Critically Ill Trauma Patients of 50 Years Old and Above PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This single-center prospective cohort study conducted at the adult trauma ICU of the Montreal General Hospital (MGH) affiliated with the McGill University Health Centre (MUHC) aims to determine the incidence and associated risk factors of augmented renal clearance (ARC) in critically ill trauma patients of 50 years old and above. |
MARC M. PERREAULT; | 2021-03-01 |
| 310 | Comparison of The Accuracy of The Neurological Prognosis at 6 Months of Traumatic Brain Injury Between Junior and Senior Doctors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: PREDICT II is an observational, prospective design, single-center study aiming to determine whether the prognosis of neurological outcome at 6 months in patients undergoing traumatic brain injury established by a doctor at his initial management is more accurate in experienced doctors versus junior doctors. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2021-03-01 |
| 311 | Could Early Atorvastatin Offer Anti Inflammatory Effects Upon Brain in Traumatic Head Injury? A Randomized Double-blind Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, known as statins, are widely used to reduce levels of low-density lipoprotein-cholesterol. As lipid-lowering drugs, statins exert neuroprotective effects on ischemic stroke. this study will investigate whether the protective effect of statins is mediated by their ability to impact inflammation and oxygen free radical levels in cerebral ischemia/reperfusion injury. Could Statins affect the neuroinflamation which occurs after traumatic brain injury? |
EMAD ZARIEF; | 2021-03-01 |
| 312 | Non-Invasive Vagal Nerve Stimulation in Veterans With Mild Traumatic Brain Injury (mTBI) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are important conditions for the Veterans Administration (VA) that frequently occur together in combat Veterans from the conflicts in Afghanistan and Iraq. In many Veterans these become chronic, raising the risk the burden of neurotrauma can worsen over time. This study will examine a new intervention called non-invasive Vagal Nerve Stimulation (nVNS) and its effects on memory and symptoms of PTSD and mTBI as well as brain and physiology in Veterans with mTBI and PTSD. |
DOUG J BREMNER; | 2021-02-25 |
| 313 | A Phase II Trial on The Safety and Efficacy of C1 Inhibitor for The Acute Management of Severe Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe Traumatic Brain Injury (s-TBI) is a major cause of death and disability across all ages. Besides the primary impact, the pathophysiologic process of major secondary brain damage consists of a neuroinflammation response that critically leads to irreversible brain damage in the first days after the trauma. A key catalyst in this inflammatory process is the complement system. Inhibiting the complement system is therefore considered to be a potentially important new treatment for TBI, … |
WILCO PEUL; | 2021-02-25 |
| 314 | A Combined Microdialysis and FDG-PET Study for Detection of Brain Injury in Comatose Survivors Resuscitated From Out-of-hospital Cardiac Arrest – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Brain injury remains the leading cause of death in comatose patients resuscitated from OHCA. One of the most challenging aspects in the treatment of a post-cardiac arrest patient is the assessment of the extent of brain damage. Reliable, clinical measures of ongoing brain injury have potential to guide individualized treatment and potentially improve outcomes. Persistent candidate measures to fill this role is combined cerebral metabolism monitoring assessed by jugular bulb microdialysis (JBM) and positron emission tomography (PET) of 18-Fluor deoxyglucose ([F-18]-FDG). This multimodal neuromonitoring is cutting-edge technology used in a clinical setting |
SIMON MÖLSTRÖM; | 2021-02-25 |
| 315 | Enhancing The Transition From Hospital to Home for Patients With Traumatic Brain Injury and Families PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite high risks of readmission and complex medical needs, there are no transitional care standards in the U.S. for patients with moderate-to-severe traumatic brain injury (TBI) discharged home from acute hospital care without inpatient rehabilitation. To enhance the standard of TBI care, we will develop and refine a patient- and family-centered TBI transitional care intervention that addresses specific needs and preferences for patients with TBI (age < 65 years) and families and will assess the feasibility, acceptability, and preliminary efficacy of the intervention. |
TOLU O OYESANYA; | 2021-02-17 |
| 316 | In-Field Detection of Acute Intracranial Hemorrhage Requiring Urgent, Life-Saving Treatment in Severe Traumatic Brain Injury (TBI) Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a research study to develop a noninvasive test using ultrasound to determine when urgent, life-saving treatment is needed for those with severe traumatic brain injuries. |
SEAN MONTGOMERY; | 2021-02-03 |
| 317 | Prediction of Secondary Neurological Deterioration in Patients With Moderate Traumatic Brain Injury : An Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with moderate traumatic brain injury (mTBI) are 1,5 times more frequent than those with severe TBI and some of them will develop secondary neurologic deterioration (SND) within the first 7 days. However, identifying at risk patients of SND is still challenging. This study aimed to determine risk factors associated with SND after mTBI. |
UNIVERSITY HOSPITAL BREST | 2021-02-03 |
| 318 | Mobilizing Early Management of Mental Health Complications After Mild Traumatic Brain Injury PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Mental health problems frequently complicate recovery from mild traumatic brain injury (mTBI) but are under-recognized and under-treated. Our research program aims to identify evidence-based strategies for closing this knowledge-practice gap. Building on a successful pilot trial, the reseachers will evaluate the effectiveness of a clinical practice guideline implementation tool designed to support proactive management of mental health complications after mTBI in primary care. |
NOAH SILVERBERG; | 2021-02-01 |
| 319 | Validation of Cognitive Enhancement Techniques for Mild Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: With an average of 21,000 diagnosed brain injuries each year among military personnel, traumatic brain injury (TBI) remains a major health concern for the United States Military Health System. Mild traumatic brain injury (mTBI) is the most common type of brain injury sustained by military personnel and may result in chronic cognitive impairment.Unfortunately, … |
THE DEFENSE AND VETERANS BRAIN INJURY CENTER | 2021-02-01 |
| 320 | Lung Microbiota in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Role of immunonutrition in modulating the lung microbiota of intubated TBJ patients and how this interaction may affect the infections and outcomes. For these reasons, the aims of our study are the evaluation of the impact of immunonutrition on the lung microbiota and the relationship between lung microbiota and infection in TBJ patients in ICU. |
COTOIA ANTONELLA; | 2021-02-01 |
| 321 | A Randomized Controlled Trial of Cognitive Rehabilitation of Working Memory After Moderate to Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to demonstrate improvement of daily life functioning and improvement of cognitive tests in post traumatic brain injury (TBI) patients suffering from working memory deficit, by a 3-month specific cognitive rehabilitation program, in comparison with patients with usual non-specific rehabilitation of same duration. As secondary objectives, the study aims to: – demonstrate improvement of specific neuropsychological tests of working memory; – demonstrate improvement of non-specific tasks involving working memory; – assess the evolution in not-targeted domains by the specific rehabilitation, which would give evidence of a global cognitive stimulation effect; – … |
CLAIRE VALLAT-AZOUVI; | 2021-01-25 |
| 322 | Effect of Targeted Temperature Management on Cerebral Autoregulation in Patients With Neurocritical Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Change and effect of cerebral autoregulation during targeted temperature management in neurocritical patients |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2021-01-22 |
| 323 | Beyond The Dynamic Coaching Model: A Treatment Comparison for Undergraduate College Students With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Up to 28% of undergraduate college students report a suspected history of traumatic brain injury. Following traumatic brain injury, college students fail and repeat more courses and have lower grade point averages. Further complicating this problem may be the fact that college students lack knowledge of traumatic brain injury definition, its associated symptoms, and individuals involved in post-injury management. In this project, the investigators propose to compare the use of an established treatment model (i.e., the Dynamic Coaching Model) to a novel protocol (i.e., … |
UNIVERSITY OF ARIZONA | 2021-01-21 |
| 324 | Transcranial Direct Current Stimulation (tDCS) and Cognitive Training to Improve Concentration and Working Memory in Active Duty Service Members Following Mild Traumatic Brain Injury (mTBI): A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS). Specifically, we will investigate how tDCS combined with cognitive training improves deficits to attention and working memory in Active Duty Service Members with a history of mild traumatic brain injury (TBI). Measures of attention-related brain activity, neurocognitive assessments, and self-reported clinical outcomes will be used to determine effects of tDCS vs. sham tDCS when paired with a cognitive training intervention. By doing this study, we hope to find a reliable, noninvasive, … |
LARS HUNGERFORD; | 2021-01-19 |
| 325 | Neurofeedback Impact on Chronic Headache, Sleep and Attention Disorders Experienced By Veterans With Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs). It is being funded by the Department of Veterans Affairs. Doing this study will help to determine if NFB will reduce chronic headaches and enhance sleep, attention and quality of life in Veterans with mTBI. NFB is like other biofeedback processes in which information about a person’s specific body functioning is made known to the person through a special computer program, … |
JUDY M CARLSON; | 2021-01-18 |
| 326 | Propranolol As An Anxiolytic to Reduce The Use of Sedatives From Critically-ill Adults Receiving Mechanical Ventilation: An Open-label Randomized Controlled Trial (PROACTIVE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic has led to shortages of intravenous sedatives due to increased ICU patient admissions and greater use of mechanical ventilation. A shortage of sedatives is as concerning as a shortage of mechanical ventilators since critically ill patients require sedation for comfort and to tolerate mechanical ventilation. Anti-adrenergic medications are increasingly recognized for their role in sedation of critically ill patients. Propranolol is a plentiful and inexpensive, non-selective beta-adrenergic blocker with good penetration of the blood-brain barrier, … |
JAMES DOWNAR; | 2021-01-08 |
| 327 | Early Induced Hypernatremia for The Prevention and Management of Brain Edema in Patients With Severe Traumatic Brain Injury in A University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to estimate the effect of an early induced hypernatremia protocol (150-155 milliequivalent/L) versus normonatremia plus mannitol (135 – 145 milliequivalent/L) in terms of neurologic outcome in patients with severe traumatic brain injury managed at critical care unit. |
JUAN C LOPEZ DE MESA; | 2021-01-02 |
| 328 | Use of Near Infrared Laser Stimulation for Treatment of Depression, Anxiety, Neurodegenerative Conditions, and Traumatic Brain Injury/Chronic Traumatic Encephalopathy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will evaluate the safety and feasibility of near infrared therapy as an intervention for patients with refractory depression, anxiety, neurodegenerative disease, and traumatic brain injury. |
SHELDON JORDAN; | 2021-01-02 |
| 329 | Mild Traumatic Brain Injury and The Risk for Traumatic Intracranial Hemorrhage in Patients on Oral Antithrombotic Therapy PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Management of traumatic brain injuries causes significant efforts on emergency departments (ED) and overall health care. Patients on antithrombotic treatment with even minor trauma to the head, although without significant clinical findings, … |
UMEÅ UNIVERSITY | 2021-01-01 |
| 330 | Baseline Reference Values for Concussion Assessments in Football PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective is to provide normal concussion assessment references values for use in football. All National Football Associations participating in The International Football Association Board’s additional permanent substitutions trial are requested to provide baseline assessment data from players within their competitions |
FEDERATION INTERNATIONALE DE FOOTBALL ASSOCIATION | 2021-01-01 |
| 331 | Concussion Assessments in Football Competitions Participating in The IFAB’s Permanent Concussion Substitution Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diagnosing and determining the severity of a sports-related concussion immediately on- or off-field is challenging, especially because clinical signs can evolve minutes to hours after the mechanism of injury. Hence, repeated follow-up and serial assessments of a player are recommended following such an injury. Current advice, when a player sustains a confirmed or suspected concussive injury, … |
ANDREAS SERNER; | 2021-01-01 |
| 332 | The Predictive Role of Seizures and Anitiepileptic Therapy on Rehabilitation Course of Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: post-traumatic seizures (PTS) are a common and debilitating complication of traumatic brain injury (TBI) and could have harmful impact on patient disabilty and rehabilitation outcome. In this multicentric prospective observational study we aimed to evaluate the role on functional outcome of patients admitted to neurorehabilitation unit afther traumatic brain injury of: – newly occurring seizures – prescription of antiepileptic prophylactic therapy The inclusion criteria were the following: 1) age ≥ 18; 2) diagnosis of TBI on presentation; 3) admission to a hospital emergency department within 24 h of injury; … |
ANTONIO NARDONE; | 2021-01-01 |
| 333 | No Cases of Delayed Intracranial Hemorrhage (d-ICH) Among Patients With Mild Traumatic Brain Injury (mTBI) on Oral Anticoagulation Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Abstract Purpose Patients with anticoagulation therapy has a higher risk of developing traumatic Intracranial Hemorrhage (tICH). Delayed Intracranial Hemorrhage (d-ICH) is a rarer clinical manifestation; however, the incidence varies from 0-9,6 % in other studies. Some studies have also questioned the clinical relevance of d-ICH, … |
UMEÅ UNIVERSITY | 2021-01-01 |
| 334 | Mindfulness Matters: The Impact of Mindfulness Based Stress Reduction on Post-Stroke Cognition PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators don’t fully understand how, regardless of the size or location in the brain, minor strokes can result in significant problems with focus, attention, and multi-tasking that prevent individuals from returning to an active lifestyle, and negatively impact quality of life; … |
ELISABETH B MARSH; | 2021-01-01 |
| 335 | A Pharmacokinetic Analysis of Levetiracetam Prophylaxis in Critically Ill Patients With Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims is to describe the pharmacokinetic properties of levetiracetam through measurement of serum concentrations in critically ill, severe traumatic brain injury patients. |
SARAH SCHUMAN HARLAN; | 2021-01-01 |
| 336 | HEAD Injury Serum Markers and Multi-modalities for Assessing Response to Trauma II PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of HeadSMART II (HEAD injury Serum markers and Multi-modalities for Assessing Response to Trauma II) is to develop an In-Vitro Diagnostic, the BRAINBox TBI test, to aid in the diagnosis and prognosis of patients with mild traumatic brain injury, by incorporating blood biomarkers, clinical assessments, and tools to measure associated neurocognitive impairments. |
FRANK PEACOCK; | 2020-12-31 |
| 337 | Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status: A Randomized Controlled Trial (BBTBBT) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Beta blockers (BB) play an important role in protection of end organs that are susceptible for secondary injury by the Traumatic brain injury (TBI)-induced catecholamine surge. However, … |
AYMAN EL-MENYAR; | 2020-12-29 |
| 338 | Caregiver SOS: An Intervention for Employed Caregivers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Unpaid informal caregivers (CGs), such as family and friends, who are also employed may be at significant risk of experiencing burden and stress. This may be especially true for CGs who provide care to care recipients coping with behavioral health issues associated with conditions like depression, anxiety, post-traumatic stress disorder and traumatic brain injury. Stress not only increases the CG’s risk of workplace difficulties, illness, and poor quality of life, but also impacts the CG’s ability to provide care for the care recipient. The primary aim of this randomized study is to examine the impact of a novel intervention, … |
SHAHRZAD MAVANDADI; | 2020-12-28 |
| 339 | Sonography of The Optic Nerve Sheath Diameter for Comparison Between The Effects of Continuous Infusion of 3%Hypertonic Saline With Intermittent Boluses Versus in Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Elevated intracranial pressure (ICP) is one of the most common symptoms encountered in a variety of traumatic injuries and diseases. Any tissue swelling within the rigid confines of the skull results in increased ICP, which may lead to life-threatening structural alterations in the brain or cerebral blood flow, thus causing oxygen deprivation and ischemia in the brain. Methods for ICP monitoring can be divided into invasive and noninvasive approaches. In fluid-based systems, … |
AMR SAMIR WAHDAN; | 2020-12-21 |
| 340 | Determining The Incidence of Vestibular Dysfunction in Traumatic Brain Injury Patients Admitted to Acute Inpatient Rehabilitation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the incidence of vestibular dysfunction in traumatic brain injury patients admitted to acute inpatient rehabilitation. This study also seeks to validate the AbilityLab Vestibular Screening Tool (AVeST) and the AVeST+, tools designed to quickly screen individuals for vestibular dysfunction following traumatic brain injury. |
DAVID RIPLEY; | 2020-12-15 |
| 341 | Improving Outcomes for Care Partners of Persons With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Care partners of persons with traumatic brain injury (TBI) are often faced with considerable physical and emotional stress resulting from their caregiver role. The researchers hypothesize that the care partners who receive the intervention will show improvements in caregiver strain and mental health. |
NOELLE E CARLOZZI; | 2020-12-09 |
| 342 | Translational Research Center for TBI and Stress Disorders: Virtual Assessment of Deployment Trauma and Rehabilitation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: For this clinical demonstration study, Veterans will be assessed with a battery of questionnaires/surveys and a 1:1 clinical interview with a V-TRACTS psychologist to target domains of head injury, psychological trauma, depression, suicidality, anxiety, chronic pain and sleep, substance use and activity level. V-TRACTS will convene a weekly consensus meeting to evaluate all the data, and develop a recommendation plan. After the consensus meeting, a V-TRACTS psychologist will provide comprehensive feedback encompassing the entire assessment battery. Additionally, if warranted, the investigators will offer an optional cognitive assessment, … |
REGINA MCGLINCHEY; | 2020-12-08 |
| 343 | Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic Brain Injury (TBI) represents a significant public health risk in the United States leaving many survivors with significant long term cognitive deficits and at risk for neurodegenerative diseases. Despite extensive research there are no pharmacological therapies which have demonstrated significant improvement in neurological or cognitive recovery. Changes in glucose metabolism are considered the hallmark metabolic response to TBI and ketosis has been proposed as a therapy to ameliorate metabolic dysfunction. This trial investigates the therapeutic potential of a ketogenic or modified Atkins diet on neurocognitive outcome following moderate-severe TBI. |
BRENDA BARTNIK-OLSON; | 2020-12-07 |
| 344 | Early Adjustment Following Open Fracture: The Impact of Viewing Psychoeducational Video Material PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The multi-disciplinary team involved in the care of major trauma patients with open fractures has developed two novel patient information videos. They include practical advice from staff about the recovery process, images of the wound throughout the healing process and ways to cope with the range of emotional responses that patients report following an open fracture. The experiences of previous patients are also included. The aim of this project is to evaluate the impact of viewing these videos on patients’ ability to follow treatment recommendations made by the team, as well as their psychological and social functioning, … |
LOUISE QUARMBY; | 2020-12-03 |
| 345 | Evaluation of Coagulation Activation in Patients With Intracranial Hypertension After Treatment With Mannitol or Hypertonic Saline Solution Related Papers Related Patents Related Grants Related Experts View Highlight: Osmotherapy consists in the therapeutic use of osmotically active substances with the aim of reducing the volume and therefore the intracranial pressure. It therefore represents an essential component in the clinical management of cerebral edema and intracranial hypertension, whether they are a consequence of head trauma, ischemic or hemorrhagic stroke, and neoplasm or neurosurgical procedures. The current study aims at evaluating in vivo the effects on haemostasis parameters of hypertonic saline solutions at different concentration, as compared to mannitol, in patients with neuroradiological signs (CT / MRI) of cerebral edema / non-traumatic intracranial hypertension. |
LICIA IACOVIELLO; | 2020-12-03 |
| 346 | Incidence and Course of Stress Hyperglycemia in Critically Ill Children Admitted to PICU of Assiut University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Detection of the prevelance of stress hyperglycemia in patients admitted to pediatric intensive care unit of Assiut university children hospital , asses its pattern ,course ,risk factors, its relation to the outcome and its management. |
SAFAA HAMED HUSSIEN; | 2020-12-01 |
| 347 | Acupuncture Treatment for Chronic Post-traumatic Headache in Individuals With Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine the effect of a low vs. high dose of acupuncture treatment in individuals with chronic post-traumatic headache (CPTH). A total of 36 people with mild traumatic brain injury (mTBI) suffering from CPTH will be enrolled in this study to receive acupuncture treatment for 5 weeks. Participants will be randomized into two groups: 1) Low Acupuncture group (5 treatments) and 2) High Acupuncture group (10 treatments). It is hypothesized that both treatment groups will have decreased headaches, but that 10 treatments will greater alleviate headaches when compared to 5 treatments. |
AMANDA A HERRMANN; | 2020-11-23 |
| 348 | Goal Attainment Evaluation of Multidisciplinary Telerehabilitation After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the outcome of a multidiscplinary telerehabilitation after traumatic brain injury assessed by the patient and the therapists with respect to the overall feasibility of the therapy protocol and the effects on psychological well-being and quality of life.. |
LEENA KORHONEN; | 2020-11-16 |
| 349 | Compensation Training to Improve Everyday Functioning of Older Adults With Mild Cognitive Impairment and Subjective Cognitive Complaints: The Digital Memory Notebook PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Compensatory aids (e.g., alarms, calendars) play an important supporting role when completing everyday tasks (e.g., appointments, medication management), and there is a growing body of scientific work suggesting that compensatory training improves daily functioning. However, traditional paper-based calendars and to-do-lists have limitations related to accumulation of information, difficulty retrieving information, and remembering to complete activities. Such limitations may be overcome using a digital format through organized digital files, search functions, and alarms. This pilot project proposes to train older adults at risk for cognitive decline to use the Digital Memory Notebook (DMN), a tablet-based application (app), … |
SARAH FARIAS; | 2020-11-11 |
| 350 | New Applications of Neuroplasticity Biomarkers in Veterans With Traumatic Brain Injury or Schizophrenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This proposal will examine measures of neuroplasticity (the brain’s ability to alter its function or structure in response to changes in the environment or novel experiences) in Veterans with schizophrenia or traumatic brain injury (TBI). Both conditions are associated with impaired cognition (for example, attention, memory, learning), which is in turn associated with poor community functioning and integration. However, … |
JONATHAN WYNN; | 2020-11-09 |
| 351 | A Real World, Multicenter, Prospective, Observational Study to Compare Effectiveness of Surgical Treatments in Patients With Acute Epidural Hematoma PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, prospective, and observational real-world study aimed at investigating the current situation of surgical treatments and prognosis for acute epidural hematoma in China, and analyzing the optimization of therapy. |
RENJI HOSPITAL | 2020-11-02 |
| 352 | Outcome PRognostication of Acute Brain Injury With The NeuroloGical Pupil PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The use of quantitative, automated, infrared technology for pupillary examination has long been used in ophthalmology and anesthesiology research. Its interest in neurocritical care has progressively grown, in parallel with the advancements in device technology. In this regard, the use of the noninvasive NPi®-200 pupillometer (Neuroptics, Laguna Hills, California, USA) allows the measurement of a series of dynamic pupillary variables (including the percentage pupillary constriction, latency, constriction velocity, and dilation velocity), which can be integrated into an algorithm, … |
GIUSEPPE CITERIO; | 2020-11-02 |
| 353 | Fast Heart Fatty Acid Binding Protein (H-FABP) Determination to Rule Out Brain Damage in Mild Traumatic Brain Injury (TBI): The First Multicenter Study Using A Point of Care Device at Trauma and Pediatric Emergency Departments. PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is defined as a structural alteration of brain function caused by external causes, where mild traumatic brain injury (mTBI) represents approximately 80% of all TBI, and although its prognosis is relatively good, it represents a significant cost to the system due to the need to perform a cranial computed tomography (CT) scan, a test of high economic value and not without risks such as irradiation, … |
JOAN MONTANER VILLALONGA; | 2020-10-28 |
| 354 | Structural and Functional Connectivity As Outcome Markers of Cranioplasty Following Decompressive Craniectomy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An Exploratory Interventional study to assess the effects of cranioplasty on brain network connectivity, neuropsychological and motor functioning in patients with severe acquired brain injury with pre-, post-cranioplasty and 6 months follow-up assessments. |
AZIENDA USL DI BOLOGNA | 2020-10-27 |
| 355 | Augmented Reality and Treadmill Training After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Up to 40 participants will be enrolled in this study in order to obtain complete data on 30 participants. The investigators will be assessing if Augmented reality in combination with treadmill training is safe and feasible to use in the clinical environment with participants who have chronic TBI and if there is a signal of effect that this intervention may be more beneficial than treadmill training alone or standard of care. |
CANDACE TEFERTILLER; | 2020-10-19 |
| 356 | Feasibility Testing of Cognitive Strategy Training in Post-Concussive Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the practicality (i.e. acceptability to stakeholders; outcome battery feasibility; recruitment, retention, and adherence rates) and the preliminary effect of a cognitive strategy training intervention in adults with post-concussive syndrome. |
ANNA BOONE; | 2020-10-15 |
| 357 | A Prospective Observational Study on Assessment of The Soluble Urokinase Plasminogen Activator Receptor in Adult Patients With Covid-19 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is the soluble form of the cell membrane-bound protein urokinase plasminogen activator receptor (uPAR), which is expressed mainly on immune cells, endothelial cells, … |
ATHANASIOS CHALKIAS; | 2020-10-11 |
| 358 | Prospective Paediatric Cohort Study of Biomarkers in The Early Management of Mild Traumatic Brain Injury and Prediction of Persistent Post-concussion Symptoms PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to identify blood biomarkers that could help in the management of paediatric patients with mild TBI. The main questions it aims to answer are: 1. How can blood biomarkers reduce unnecessary CT scan and reduce the length of stay at the emergency department? 2. How can blood biomarker predict post-concussion symptoms? Participants will have a blood sample taken when they are admitted at emergency department and will receive a questionnaire describing their symptoms 14 days and 3 months after their trauma. |
SERGIO MANZANO; | 2020-10-06 |
| 359 | Diet Induced Ketosis for Brain Injury – A Feasibility Study: A Ketogenic Diet With MCT Supplementation As A Potential Treatment for Brain Injury in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Each year, approx. 100 patients with severe brain injury is admitted to the Clinic for Neurorehabilitation/TBI Unit, Rigshospitalet. Severe brain injury results in local oxygen deficiency and acid formation in the brain, which together destroys brain cells. The purpose of this study is to investigate whether it is possible to carry out a ketogenic diet therapy for patients with severe brain injury for six weeks. Ketosis has been shown to be neuroprotective during and after severe brain injury. |
JENS RIKARDT ANDERSEN; | 2020-10-05 |
| 360 | Stellate Ganglion Block As Adjuvant Therapy to Ca Channel Blocker in Prevention of Cerebrovascular Spasm in Traumatic Subarachnoid Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of work: To evaluate the effect of stellate ganglion block in prevention of cerebrovascular spasm in traumatic subarachnoid hemorrhage Primary outcome: Asses changes of cerebral blood flow velocity by Trans cranial Doppler. Secondary outcome: Asses changes in clinical status |
M MOSTFA YOUSSEF MEKKY; | 2020-10-01 |
| 361 | Diagnostic Role of Serum Testican and Ubiquitin Levels in Patients With Head Trauma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We aimed to determine if testican-1 and ubiquitin can serve as early indicators for diagnosing worsening clinical course (presence of intraparenchymal pathology) and mortality in patients with moderate traumatic brain injury. |
RAMIZ YAZICI; | 2020-10-01 |
| 362 | Efficacy of Superior Cervical Ganglion (SCG) Block on The Incidence and Severity of Vasospasm After Middle Cerebral Artery (MCA)Aneurysmal Surgery Using Transcranial Doppler(TCD). A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess blood flow velocity in middle cerebral artery measured by transcranial doppler to determine the efficacy of SCG block in decreasing incidence or severity of vasospasm after MCA aneurysm surgery. |
FATMA IBRAHIM EL SAYED SALMAN; | 2020-10-01 |
| 363 | Effect of Decompressive Craniectomy Following Traumatic Brain Injury: One Year Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective clinical trial on trauma patients with increased intracranial pressure(ICP) applied for decompressive craniectomy to lower ICP |
ALAA ELDEEN MOHAMED OREABY ADAM; | 2020-10-01 |
| 364 | Exercise As Concussion Therapy Trial Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a Phase 2, open-label study of a therapeutic intervention (graded exercise)compared to a reference therapy (passive stretching) in patients who have sustained mTBI. Subjects will be randomly assigned with a ratio of 1:1 to complete either graded exercise or passive stretching using a parallel-group design. The effects of graded exercise and passive stretching will be compared using ClearPlay© (ANSwers Neuroscience Pty Ltd commercial mobile application) The study will also validate the performance of two devices: 1. ClearHeart©, ANSwers Neuroscience Pty Ltd commercial prototype for cold pressor testing, compared to ice bucket testing. 2. ClearPlay©, … |
ANSWERS NEUROSCIENCE | 2020-10-01 |
| 365 | Standardized Instruments to Provide Diagnostic and Prognostic Information in Mild Traumatic Brain Injury (mTBI) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will establish the capability of a suite of conventional tests and the Neurolign Dx_100 I-PAS goggle system to reliably and objectively detect mTBI in an acute setting when comparing individuals with mTBI to controls with minor injuries in a similarly stressful environment. |
CAREY BALABAN; | 2020-09-30 |
| 366 | Pilot Study to Improve Ambulation in Individuals With Traumatic Brain Injury (TBI) Using Virtual Reality -Based Treadmill Training PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to test the effectiveness of virtual reality (VR) based treadmill training on walking ability. The study will also help to understand the changes in cognitive ability and brain activity as a result of VR-based treadmill training after a brain injury. The study will include 3 groups: C-MILL training group (CTG), Treadmill training group (TTG), and healthy control group (HCG). Individuals with brain injury will be randomly assigned to C-MILL training group, … |
KIRAN KARUNAKARAN; | 2020-09-30 |
| 367 | Potential Impact of Amantadine on Traumatic Brain Injury Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate whether the addition of amantadine to the management regimen of traumatic brain injury patients would have a favorable effect on recovery and neurological complications in association with prognosis biomarkers Interleukin-18 (IL-18), Neuron-specific enolase (NSE) and (Neurotensin). |
REHAB WERIDA; | 2020-09-30 |
| 368 | Assessment and Rehabilitation of Social Cognition in People With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients who have suffered moderate to severe traumatic brain injury (TBI) frequently develop behavioural changes, which can have deleterious consequences on interpersonal relationships, social, family and professional reintegration. They are a source of difficulties (burden) for family and friends. Social cognition covers four functions: recognition of social cues; empathy; attribution of intentions to a third party, or theory of mind; and adjustment of social behaviour according to context. This study has two parts: 1/ Evaluation, using a cognitive approach, of the different components of social cognition after moderate to severe traumatic brain injury, … |
CENTRE D’INVESTIGATION CLINIQUE ET TECHNOLOGIQUE 805 | 2020-09-24 |
| 369 | Rehabilitation of Executive Function in Aging Veterans With History of TBI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will use technology to deliver effective treatment for cognitive problems associated with TBI to Veterans at home, which may result in improved daily functioning and increased access to health care for the growing population of aging Veterans with history of TBI. The successful completion of this project may also increase older Veterans’ ability to participate in research through increased understanding of the effect of in-home research opportunities on recruitment and retention. Additionally, the evidence gathered from this study may be used in future research studying home-based cognitive rehabilitation treatments for Veterans using telehealth technology. |
ERICA S. KORNBLITH; | 2020-09-09 |
| 370 | Prediction of Short-term Outcome in Patients With Acute Closed Traumatic Brain Injury Using Magnetic Resonance Elastography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is a major public health issue, and intracranial hypertension in the acute phase remains a critical scientific issue. Many patients with acute closed TBI received conservative, non-surgical treatments at first, while 5%~19% of which develops intractable intracranial hypertension that requires emergent surgery. Therefore, it is of great clinical significance to identify patients who are at high risk of deterioration in the early stage. Previous studies have found that brain compliance is a contributive factor to intracranial pressure, … |
JINFANG LIU; | 2020-09-01 |
| 371 | The Effects of Transcranial Direct Current Stimulation (tDCS) and Cognitive Training on Episodic Memory and Attention in Patients With Traumatic Brain Injury: A Double-blind, Randomized, Placebo-controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Long-term sequelae in TBI is a well-recognized burn. We designed a proof of concept study, randomized, double-blind, placebo-controlled to evaluate 36 adult TBI patients. To evaluate the early and late effects of 10 days of 20 minutes applying transcranial direct-current stimulation (tDCS) in the dorsolateral prefrontal cortex (DLPFC), bilateral temporal cortex (CTB) and compare to sham stimulation, and online cognitive training. We expect that the active group will differ from the sham group, showing larger effect sizes in the cognitive assessment. |
WELLINGSON SILVA PAIVA; | 2020-09-01 |
| 372 | The Influence of Noradrenaline Infusion on Coagulation and Fibrinolysis in Patients With Isolated Severe Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of the study The investigators aim to establish: – Whether noradrenaline (NA) infusion has a significant effect on coagulation and fibrinolysis in patients with severe traumatic brain injury (TBI). – Whether disruption of haemostasis can be recorded with a computerized tomography (CT) scan. – Whether there is a significant difference between the values of haemostasis parameters in the internal jugular vein and the radialis artery. The hypotheses 1. In the early stage of treatment (1-3 hours), an increased formation of thrombin occurs in patients with severe isolated TBI that are treated with NA; consequently, … |
ADELA STECHER; | 2020-09-01 |
| 373 | Effectiveness of Stroke Riskometer Apps In Improving Awareness of Stroke Risk and Stroke Risk Probability Among Young Adult Population In Kelantan: An App-Based Intervention Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This intervention study using the Stroke Riskometer Apps as health promotion and disease prevention tools for the stroke prevention. Study will specifically target the young adult population (18-50 years old) who are the population at risk for young stroke. The study will determine the effectiveness of Stroke Riskometer Apps by assessing the awareness (knowledge, perception of stroke risk and intention to change behaviours) using the translated ABCD risk questionnaire and stroke risk probability using Stroke Riskometer Apps. |
MOHAMAD ZARUDIN BIN MAT SAID; | 2020-08-31 |
| 374 | The Effect of Different Modes of Mechanical Ventilation on Cerebral Blood Flow During Thoracoscopic Surgeries in Neonates (RCT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the aim of this study is to compare the effect of different modes of mechanical ventilation by using volume-controlled ventilation and pressure-controlled ventilation on cerebral blood flow monitored by cerebral oximetry during thoracoscopic surgeries in neonates. |
HUSSAM HASSAN; | 2020-08-08 |
| 375 | Prediction of Massive Transfusion in Trauma Patients in Prehospital and In-hospital: Data From Swiss Trauma Registry (STR) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Since the 2000s, many prognostic scores were developed to predict traumatic haemorrhage. Most of these studies were retrospectives based on registers. Due to missing data on death due to bleeding, these studies chose to predict the massive transfusion risk as a surrogate of haemorrhagic death. These scores include clinical parameters (vital signs), laboratory values (Haemoglobin, lactate, Base excess) and/or imaging (CT or ultrasound) values. The scores showing best performance are the Trauma Associated Severe Haemorrhage (TASH) score, developed and validated on the German register (DGU-Register) and the ABC score developed and validated in the United States of America. However, … |
ALAN COSTA; | 2020-08-01 |
| 376 | The Primary Prevention Study of Post-Ischemic Stroke Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Advance in stroke treatment have resulted in a dramatic reduction in the stroke mortality, however, the number of stroke survivors living with morbidity has increased significantly. As we know, post-stroke epilepsy has been identified as a significant clinical issue in stroke survivors and stroke is the most common cause of epilepsy in older adults and for patients aged more than 65, post-stroke epilepsy accounts for 30-50% of new-onset seizures. Our previous study documented seizures during stroke presentation and during hospitalization would worsen the overall morbidity and mortality, … |
CHIN-WEI HUANG; | 2020-08-01 |
| 377 | Buspirone and Melatonin for Depression Following Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination. The current research group conducted a pilot clinical trial, which investigated the novel treatment combination of buspirone and melatonin (B+MEL) in outpatients with clinical depression. Compared to placebo, … |
KALOYAN TANEV; | 2020-08-01 |
| 378 | Comparison of Frequency & Duration of Task Practice During Constraint-Induced Movement Therapy on Lower Limb in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stroke is a very serious medical condition, classically categorized as a neurological disorder that occurs due to obstructed blood flow to specific parts of the brain, and resultant death of that area.This obstructed blood supply results in compromised function of that part of the brain, resulting in paralysis or interference with the normal function of the body controlled by that specific region of the brain. Stroke is usually of two types i.e. Ischemic and hemorrhagic. Ischemic stroke results in reduced or complete obstruction in blood flow in the vessels resulting in ischemia, … |
AYESHA AFRIDI; | 2020-08-01 |
| 379 | Dexamethasone for The Treatment of Traumatic Brain Injured Patients With Brain Contusions and Pericontusional Edema: Study Protocol for A Prospective, Randomized and Double Blind Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The DEXCON-TBI trial is a multicenter, pragmatic, randomized, triple-blind, placebo controlled trial to quantify the effects of the administration of dexamethasone on the prognosis of TBI patients with brain contusions and pericontusional edema. Adult patients who fulfil the elegibility criteria will be randomized to receive dexamethasone or placebo. Patients who have suffered a head injury and have one or more cerebral contusions with visible pericontusional edema in the CT scan can be included in the study. The doses of dexamethasone will be a short and descending course: 4mg/6 hours (2 days); 4 mg/8 hours (2 days); … |
JON PÉREZ BÁRCENA; | 2020-07-24 |
| 380 | Early Diagnosis of Mortality Using Admission CT Perfusion in Severe Traumatic Brain Injury Patients (ACT-TBI Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Severe traumatic brain injury (TBI) is a principal cause of post-injury hospitalization, disability, and death throughout the world. TBI is the leading cause of death and disability among young healthy people under 45 years of age and is predicted to be the most prevalent and costliest neurological condition in Canada through the year 2031. TBI is commonly classified into mild, moderate, and severe categories using the Glasgow Coma Scale (GCS), with severe TBI defined as a GCS score ≤ 8. Severe TBI is a clinical emergency, … |
JAI SHANKAR; | 2020-07-23 |
| 381 | Impact of Mode of Anesthesia on Ischemia Modified Albumin (Abiomarker of Oxidative Stress) and Outcome in Patients With Traumatic Brain Injury Undergoing Emergency Craniotomy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the current study the investigators intend to evaluate the mode of anesthesia on ischemia modified albumin and outcome in patients with traumatic brain injury undergoing emergency craniotomy |
ABD-ELRAHMAN HASSAN ABD -ELAZIZ; | 2020-07-23 |
| 382 | A Randomized, Controlled, Blinded Study of Internet-guided Cognitive Behavioral Therapy for Insomnia in Military Service Members With History of Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to validate an established internet-guided cognitive behavioral therapy for insomnia (CBT-I) as an alternative program to traditional in-person therapy that may increase treatment availability and utilization within the military health system. The version of the internet-guided CBT-I program being studied has been customized specifically for military service members. The study will assess if the customized internet-guided CBT-I program will positively improve clinical measures of insomnia and quality of life outcomes in active or retired service members with primary insomnia and associated mild traumatic brain injury. |
DAVID L BRODY; | 2020-07-07 |
| 383 | One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Mild traumatic brain injury (mTBI) is the signature wound of Veterans returning from the operations in Iraq and Afghanistan (i.e., OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms. Among Veterans with mTBI, the majority also experience stress-based psychopathology (e.g., depression, post-traumatic stress disorder, and/or generalized anxiety disorder) and chronic pain. To cope with distress, pain, and other difficulties, Veterans often turn to maladaptive avoidant coping strategies which offer short term relief but exacerbate/maintain mental health problems and have detrimental long-term effects on social, occupational, and community reintegration. Unfortunately, Veterans face important barriers to seeking mental health treatment, … |
LILIAN N. DINDO; | 2020-07-01 |
| 384 | The Effect of Acupressure on Relieving Fatigue Following Traumatic Brain Injury: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fatigue is a common symptom experienced by patients with traumatic brain injury (TBI). Prior works have demonstrated that it may profoundly impact the ability to return to productive activity and cognitive functions. However, few interventions have been applied in this population.The purpose of the current will be to test the effect of acupressure on fatigue reduction after traumatic brain injury. |
HSIAO-YEAN CHIU; | 2020-07-01 |
| 385 | Feasibility Trial of A Goals of Care Decision Aid for Families of Critically Ill Stroke Patients Related Papers Related Patents Related Grants Related Experts View Highlight: Severe strokes, including large artery acute ischemic stroke and intracerebral hemorrhage, continue to be the leading cause of death and disability in adults in the U.S. Due to concerns for a poor long-term quality of life, withdrawal of mechanical ventilation and supportive medical care with transition to comfort care is the most common cause of death in severe strokes, … |
SUSANNE MUEHLSCHLEGEL; | 2020-07-01 |
| 386 | Correlation Between Non-motor Symptoms and Malnutrition in Patients With Parkinson’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study used Mini Nutrition Assessment (MNA) , Nutrition risk screening 2002(NRS-2002) and Non-motor Symptom Quest (NMSquest) to investigate the nutritional status of patients with Parkinson’s disease, to analyze the correlation between non-motor symptoms and malnutrition in patients with Parkinson’s disease (PD) , and to provide evidence for clinical treatment and early nutritional intervention. |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2020-06-30 |
| 387 | A Prospective, Open-Label, Single-Arm, Single-Center, Explorative Clinical Trial to Assess The Effect and Safety of Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Low-intensity focused ultrasound can be effective in severe TBI patients with disorder of consciousness. This study is a prospective single arm, open-label and explorative clinical trial to evaluate the therapeutic effect of recovery from DoC and safety of low-intensity focused ultrasound stimulation at thalamic area in patients with post-traumatic DoC. |
BYUNG-MO OH; | 2020-06-25 |
| 388 | The Research for New Clinical Diagnostic Strategy of Specific Biomarkers for Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is the most common type of nerve injury and it severely endangers the public health. It is necessary to accurately measure the early neurological function of brain injury for monitoring its prognosis and therapeutic interventions. Glasgow Coma Score (GCS) and Computed Tomography (CT) are often used to diagnose the severity of TBI. However, GCS has its drawbacks in the observation of prognosis, because it is interfered by analgesics, … |
BAIYUN LIU; | 2020-06-04 |
| 389 | Do Combinatorial Training Lead to Better Cognition and Daily Participation in TBI Persons With Cognitive Impairments: Efficacy and Neural Mechanism of Combining Computerized Cognitive Training, Aerobic Exercise and Guided Training PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this study are to: (1) determine the effects of combinatorial training (i.e. combinatory of aerobic exercise with cognitive training and guiding training) vs. the sequential training (i.e. a combination of aerobatic exercise with cognitive training) on cognitive function, physical function, and daily function/participation and psychological function in persons with cognitive impairments post Traumatic brain injury (TBI); (2) determine the long-term effects of these two types of interventions on these outcome measures. |
CHING-YI WU; | 2020-06-03 |
| 390 | Effects of Vestibular Rehabilitation in Patients With Severe Traumatic Brain Injury: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe brain injury (sTBI) is one of the most common causes of long-term disability and is considered the most frequent cause of mortality and serious disability in young adults in industrialized countries. It is defined as an alteration of brain function with loss of consciousness in the acute phase for at least 24 hours (Glasgow Coma Scale (GCS) <8) and it can induce a wide range of deficit, including cognitive-behavioural, motors, psychics, language, vision, ... |
MARCO TRAMONTANO; | 2020-06-01 |
| 391 | A Randomised Controlled Trial to Evaluate Decompressive Craniectomy for Patients with Cerebral Herniation Undergoing Evacuation of Acute Epidural Hematoma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Although craniotomy provides a more complete evacuation of the acute epidural hematoma, there are insufficient data to support specific surgical treatment method. We aim to perform a multi-center, parallel-group randomized clinical trial to compare the outcome and cost-effectiveness of decompressive craniectomy versus craniotomy for the treatment of traumatic brain injury patients with cerebral herniation undergoing evacuation of an acute epidural hematoma. |
JUNFENG FENG; | 2020-05-23 |
| 392 | Biochemical Diagnostics of Mild Traumatic Brain Injury (TBI) and Concussion in Children and Adolescents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will enroll children and adolescents (0 – 17 years) suspected of having concussion or mild traumatic brain injury (TBI). Samples of urine and saliva will be collected from the patients as well as from corresponding age- and gender-adjusted healthy controls. |
SARI MALMI; | 2020-05-14 |
| 393 | Functional Near Infrared Spectroscopy As A Biomarker of Response in Patients With Post-concussion Syndrome Treated With Transcranial Magnetic Stimulation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Every year, approximately 2 million people in the United States and 280,000 in Canada experience a mild traumatic brain injury/concussion. In patients with concussion, symptoms experienced following injury usually get better within 3 months. However, approximately 5-25% of people will experience symptoms beyond the 3 month period, characterized by persistent headaches, fatigue, insomnia, anxiety, depression, and thinking or concentration problems, which contribute to significant functional impairment. Chronic headache is the most common symptom following concussions. They can last beyond 5 years following injury, significantly impacting daily activities. To date, … |
CHANTEL T DEBERT; | 2020-05-02 |
| 394 | Balance and Mobility in Older Adults With Hearing Impairment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hearing impairment is common in older adults, and recent research points to associations between hearing impairment and balance/mobility. The association may be due to more attentional resources being used to compensate for the sensory loss, with less resources available for maintaining balance. The aim of this projects is therefore to investigate whether an exercise program with focus on motor-cognitive tasks is feasible for older adults with hearing impairment. The study is meant as a proof-of-concept study, where trialling will be evaluated, and results will be used to inform the design of a larger and adequately powered study. |
BÅRD BOGEN; | 2020-05-01 |
| 395 | Cognitive Impairment and Clinical Characteristics in Patients With Chronic Obstructive Pulmonary Disease: Retrospective Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Prior researches suggest the presence of impaired lung function may be linked to cognitive impairment (CI). A recent study shows that lung disease, and specifically Chronic obstructive pulmonary disease (COPD) are associated to a greater risk of CI in a population of 14,184 individuals followed for over 23 years. Moreover, the study shows that low forced expiratory volume in 1 second (FEV1) is associated to an increased risk of dementia and MCI, indipendently of smoking habit. |
PATRIZIA RUSSO; | 2020-04-28 |
| 396 | Evaluation of The Effect of Endotracheal Suctioning Applied at Different Head Height on Oxygenation of The Brain By Non-Invasive Method in Intensive Care Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In order for the brain, which is the most metabolically active organ of our body, to maintain its functions, it must reach oxygen saturation in the best way with continuous and rich blood flow. Neurosurgery patients are followed for a while in the intensive care unit with a mechanical ventilator. During the care of the patient in mechanical ventilation; position changes, head height, endotracheal aspiration, oral care and invasive procedures that cause painful stimuli to the patient are factors that can affect brain perfusion pressure and oxygenation status of brain cells. It is known that high intracranial pressure, … |
SIBEL KÖSTEKLI; | 2020-04-01 |
| 397 | A Health and Wellness Lifestyle Program to Support Community-Dwelling Persons With Traumatic Brain Injury (TBI) and Their Caregivers: In-House Research Project, Objective 2 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy of an adapted telehealth-based, health and wellness lifestyle program on promoting healthy lifestyle behaviors and improving health outcomes. |
LAURA E. DREER; | 2020-04-01 |
| 398 | Utility of Pupillary Metrics in Diagnosis and Management of Concussion in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to gather information and compare the potential use of pupillometry to identify concussions and post concussive syndrome with standard age appropriate assessments. The study will compare concussed pediatric patients 5-17 years of age recruited from the emergency department within 72 hours following injury with age and gender matched non-concussed pediatric patients recruited from primary care clinics. Assessment of both concussed and non-concussed subjects will take place at the initial enrollment visit and will be repeated at 1-2 weeks for the concussed subjects and at 12-14 weeks for both groups. |
THEODORE HEYMING; | 2020-03-11 |
| 399 | Evaluation of Antisecretory Factor in Treatment of Severe Traumatic Brain Injury With Multimodal Monitoring PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the addition of Salovum, an egg yolk powder enriched for antisecretory factor, to standard care of participants with severe traumatic brain injury. Half of the participants will be administered Salovum while the other half will be given a placebo egg yolk powder, not enriched for antisecretory factor. Intracranial pressure (ICP), partial brain oxygen pressure (PtbO2), microdialysis of metabolites and inflammatory mediators and trauma intensity level (TIL) will be assessed in all patients. |
PETER SIESJÖ; | 2020-03-10 |
| 400 | Efficacy of A Telehealth Pain Self-Management Intervention in Employed Adults With Physical Disability: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with physical disabilities who are employed. Participants from anywhere in the US will be randomized to either E-TIPS, a cognitive-behavioral pain self-management intervention delivered by telephone, or a waitlist control. Outcomes, including pain interference, will be assessed at baseline, mid-treatment, post-treatment, and 6-month follow up. |
DAWN EHDE; | 2020-03-02 |
| 401 | Prevention of Epilepsy By Reducing Neonatal Encephalopathy PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to examine if a pragmatic, evidenced based and generalisable intrapartum care bundle involving birth companions and empowering mothers will reduce birth injury-related epilepsy at 18 months of age in India. The care bundle will have four key elements (interventions): (1) birth companion providing constant 1:1 care during labour and early perinatal period; (2) fetal surveillance during active labour by a nurse or midwife using a graphic display Doppler; (3) labour management by an electronic partogram with an ‘alert’ and ‘nag’ feature based on the current WHO guidelines; … |
MINI CHENICHERI; | 2020-03-01 |
| 402 | Iatrogenic Withdrawal Symptoms in Severe Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Iatrogenic withdrawal symptomes has been associated with prolonged mechanical ventilation and the and the derived symptoms such as fever and agitation has been shown to cause significantly prolonged ICU and hospital length of stay. The incidence of IWS in the adult general ICU ranges from 16,7-55%. To this date, the incidence of IWS has not been studied in patients with TBI. |
MARKUS HARBOE OLSEN; | 2020-03-01 |
| 403 | Participation and Executive Functions in Adults Following Traumatic Brain Injury During Sub-Acute Inpatient Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim: To examine the feasibility of a new treatment protocol in improving executive functions deficits and participation in daily activities of adults with TBI at discharge and one month post discharge. A single blind (assessors) randomized control trial (RCT) with two groups, experimental and control . This study will include 40 adults hospitalized in the inpatient Head Trauma unit. Potential patients will be approached by occupational therapists working in the inpatient Head Trauma rehabilitation unit and be invited to participate in the study. If they agree, … |
ROTEM ELIAV; | 2020-03-01 |
| 404 | Hyperbaric Oxygen Therapy for Chronic Unremitting Post-Traumatic Stress Disorder (PTSD): A Prospective, Randomized, Double Blind Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study evaluates the effect of hyperbaric oxygen therapy on veterans with combat-associated PTSD in an double blind sham control study. |
KEREN DOENYAS; | 2020-02-25 |
| 405 | Initiation of An Early Exercise Program to Improve Symptoms and Psychosocial Function After Pediatric Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will test the central hypotheses according to the following Specific Aims: Aim 1. Determine if an individually prescribed exercise program initiated within the first week of mild traumatic brain injury can reduce the risk of developing persistent post-concussion symptoms relative to usual care. The investigators hypothesize that the exercise group will have a lower risk of developing persistent post-concussion symptoms than the usual care group. Aim 2. Examine the effect of a two-month exercise program on psycho-social, pain interference, and sleep outcomes following mild traumatic brain injury. The investigators hypothesize the exercise group will report lower anxiety, depression, … |
DAVID R HOWELL; | 2020-02-20 |
| 406 | Investigation of Neural Mechanisms Associated With Sleep-Dependent Enhancement of Motor Learning After Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Studies have shown that a period of sleep, even in the form of a daytime nap, after a period of training on a motor learning task can boost subsequent performance beyond that observed after an equal amount of time spent awake and resting. This leap in performance has been referred to as off-line motor learning because it occurs during a period of sleep in the absence of additional practice. Motor learning is an integral part of the physical and occupational therapy that patients receive after traumatic brain injury (TBI) in which various activities of daily living may need to be relearned. Targeted motor skills may include dressing (learning how to zip up a jacket or button a shirt), using a fork and knife to eat, or using technology (tapping touch screen on a cell phone or typing on a computer). Yet the potential of sleep in the form of a strategic nap as a therapeutic tool to maximize motor learning in rehabilitation therapies has not been fully realized. In addition, a growing body of research among healthy individuals has shown evidence of changes in the brain associated with enhanced performance among those who slept following training compared with those who spent the same amount of time awake. The neural mechanisms of off-line motor learning have not been studied among individuals with TBI. Using functional neuroimaging and measurement of brain waves, the current study will examine the mechanisms underlying this sleep-related enhancement of motor learning among individuals with TBI and determine how brain physiology may influence the magnitude of the effect. By understanding how this treatment works and identifying the factors that modulate its effectiveness we can identify which individuals will be most likely to benefit from a nap after training to improve motor learning after TBI. This can provide a more person-centered approach to treatment delivery that can maximize the effectiveness of a simple but potent behavioral intervention. |
ANTHONY LEQUERICA; | 2020-02-18 |
| 407 | The Effect of Platelet Bioenergetics in Traumatic Brain Injuries Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective study enrolling 5 patients with a diagnosis of traumatic brain injury (TBI) without polytrauma and 5 patients with TBI with polytrauma admitted to the University of Kentucky (UK) Chandler Medical Center to evaluate differences in platelet bioenergetics in the populations. Additionally, five healthy subjects will be recruited to the control group. |
KEVIN HATTON; | 2020-02-13 |
| 408 | Acupuncture for Headache Post-Traumatic Brain Injury: A Feasibility Study Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates and addresses challenges to implementing an acupuncture intervention for adults who have headaches after sustaining a moderate traumatic brain injury. Eligible participants will be recruited from Seattle and the surrounding areas to receive weekly acupuncture for 12 consecutive weeks. Participants will complete questionnaires to assess headache impact, depression, health-related quality of life, and cognitive function at the beginning of the study and every two weeks for the duration of the study. Participants will participate in structured interviews after the study for their views on the acceptability and tolerability of the study protocol. |
MARK SODDERS; | 2020-02-06 |
| 409 | Transcranial Ultrasonography for The Management of Patients With Mild Traumatic Brain Injury PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators hypothesize that patients with mild TBI and normal TCD can be safely discharged home immediately after the ED. The targeted population is the category of patients eligible for early discharge: 1) patients with mild lesions on the initial CT scan and a GCS 15 after CT scan completion and, 2) patients with no lesion on the initial cerebral CT scan with at least one of the following risk factors: GCS 14 after CT scan completion, persisting post-traumatic nausea/vomiting/headaches, … |
PIERRE BOUZAT; | 2020-02-01 |
| 410 | A Multicenter Observational Cohort for The Determination of Noninvasive Intracranial Pressure Waveforms Role in Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In clinical practice, hospital admission of patients with altered level of consciousness ranging from drowsiness to decreasing response states or coma is extremely common. This clinical condition demands effective investigation and early treatment. Imaging and laboratory tests have played increasingly relevant roles in supporting clinical research. One of the main causes of coma is intracranial hypertension (IH), with traumatic brain injuries (TBI) and cerebral hemorrhages being the major contributors to its development. IH increases the risk of secondary damage in these populations, and consequently, … |
SERGIO BRASIL; | 2020-02-01 |
| 411 | Imaging of Glial Activation and Risk for Post-Traumatic Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will undergo PET scans of the brain at two weeks and two months after injury to measure neuro-inflammation. The results of the PET scans will be analyzed and correlated with the risk of post-traumatic epilepsy. |
RYAN M MARTIN; | 2020-02-01 |
| 412 | Doxycycline Effects on Neurological Outcomes in Patients With Acute Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: evaluate the impact of Doxycycline on both clinical outcome and blood levels of NSE in patients with TBI. |
REHAB WERIDA; | 2020-02-01 |
| 413 | Evaluation of The Effect of Early Administered Neuroprotective Drug on Treatment Result in Patients After Traumatic Brain Injury – PILOT Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic Brain Injury TBI is one of the most common causes of death and recovery failure worldwide. Each element of treatment, starting from possible surgical treatment, patient monitoring and neuroprotective treatment, … |
KLAUDYNA KOJDER; | 2020-02-01 |
| 414 | Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: evaluation of the effect of Propranolol versus propranolol and clonidine on decreasing sympathetic hyperactivity after moderate traumatic brain injury |
FATMA RABEA MOHAMMED; | 2020-01-31 |
| 415 | Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury (OCEANS-TBI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with a history of traumatic brain injury (TBI) are at elevated risk for Alzheimer’s disease and related dementias (ADRD). Improvements in TBI treatment may mitigate this risk. Complex motor activities, which combine physical and cognitive demands, have been shown to have well established neurocognitive benefits. This study seeks to address the need for novel TBI interventions optimized for adults with history of TBI by determining the effectiveness of an immersive computer game designed to integrating complex cognitive-motor interventions. |
MATTHEW E PETERS; | 2020-01-25 |
| 416 | A Pilot Study to Estimate Intracranial Pressure Noninvasively in Traumatic Brain Injury Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Researchers have developed a probe that contains infrared light sources that can illuminate the deep brain tissue of the frontal lobe. Photodetectors in the probe detect the backscattered light, which is modulated by pulsation of the cerebral arteries. Changes in the extramural arterial pressure affect the morphology of the recorded optical pulse, so analysis of the acquired signal using an appropriate algorithm could enable the calculation of the intracranial pressure noninvasively (nICP), … |
CHRISTOPHER UFF; | 2020-01-20 |
| 417 | Prediction for Coma Recovery in ICU With Comaweb: A Validation Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to simple orders after traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhages (aSAH) and cardiac arrest (CA) in the day 7 – day 45 period post brain injury. |
PUYBASSET LOUIS; | 2020-01-15 |
| 418 | Develop and Rehabilitation Effects of The Safety Aerobic Exercise Prescription on Cognition, Depression and Quality of Life in Traumatic Brain Injury Patients- Taking The Cerebral Blood Circulation As A Mediator PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to develop exercise prescription of TBI patients and then to evaluate the effectiveness of programmed aerobic walking exercise to improve cognitive performance, depression relief, motivation, symptom, resilience and quality of life with improvement of CBF. This will be a randomized controlled clinical trial, using a mixed method to explore the feasibility and validity of such a safety exercise prescription. Then, a randomized clinical control trial will be applied in TBI patients to evaluate the effectiveness of programmed aerobic exercise to promote psysical-psycho-social health such as cognitive status, 6 minutes walk test, depression relief, motivation, … |
HUI-HSUN CHIANG; | 2020-01-01 |
| 419 | Prediction of Neurological Outcome of Children After A Moderate or Severe Traumatic Brain Injury, Based on An Integrated Predictive Model (Serum Biomarkers, Heart Rate Variability, Computerized Classifier Output) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to develop a integrated predictive model based on serum biomarkers, HRV, and an innovative computerized classifier output, to predict the patient long term neurological outcome after a moderate or severe TBI in children. |
LAURENCE DUCHARME-CREVIER; | 2020-01-01 |
| 420 | A Clinical Trial to Determine The Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for The Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury in adults. |
CHARLES S COX; | 2020-01-01 |
| 421 | Artificial Intelligence Analysis of Initial Scan Evolution of Traumatic Brain Injured Patient to Predict Neurological Outcome: Pilot Translational An Exploratory Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We assume that an early iterative automatic CT scan analysis (D0, D1 and D3) by different AI approaches will allow an early differentiation of the tissues evolution after TBI. Our objective is to couple theses scan profiles to a neurological evolution, measured by therapeutic intensity. |
PIERRE BOUZAT; | 2020-01-01 |
| 422 | Spectral Correlates of Impulsivity in Patients With Traumatic Brain Injury: A Study of The Effect of Transcranial Electrical Stimulation of The Ventrolateral Prefrontal Cortex on Response Inhibition Related Papers Related Patents Related Grants Related Experts View Highlight: Transcranial electrical stimulation (tES) is a non-invasive form of brain stimulation that has previously been to shown to have therapeutic potential in traumatic brain injury (TBI) patients. In this study, the study team will use a brain activity monitor (electroencephalogram, EEG) and a computer-based task to observe the effects of different forms of tES, like transcranial direct current stimulation (tDCS) and transcranial pulsed current stimulation (tPCS), on impulse control and sustained attention in people with TBI. Additionally, … |
NATHAN ROWLAND; | 2020-01-01 |
| 423 | Does Working on Single Leg Stance (SLS) Alongside Usual Physiotherapy Treatment Lead to A More Efficient Gait Pattern As Measured By The 10m Walk Test (10MWT) Compared to Those Receiving Usual Physiotherapy Only in Adults With Acquired Brain Injury? An Exploratory Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to see if a person can stand better on their weaker leg does this improve their walking ability following treatment specifically aimed at standing on leg. This will be compared to people who receive normal physiotherapy treatment not treatment specifically focusing on their ability to stand on their weaker leg. The study is being carried out as part of the researcher’s Masters Degree. Participants will be allocated to either the control group (normal physiotherapy treatment) or the experimental group (normal physiotherapy plus physiotherapy working specifically on standing on the weaker leg). There is currently some evidence to show that working specifically on standing on one leg can improve a person’s walking but this evidence is limited. Consequently, further research is warranted to identify any links between this treatment approach and walking ability. |
MANCHESTER UNIVERSITY NHS FOUNDATION TRUST | 2019-12-24 |
| 424 | Comparison of Two Group Wellness Interventions in Partner Caregivers of Individuals With Traumatic Brain Injury: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to compare the effect of two different types of group wellness interventions for partner caregivers of individuals with traumatic brain injury (TBI). The study is designed to evaluate how well these treatments can help TBI partner caregivers improve approach/avoidance behaviors. |
DENISE KRCH; | 2019-12-15 |
| 425 | Using Virtual Reality to Improve Job Reentry in Adults With TBI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to investigate the effectiveness of virtual reality (VR) to improve job reentry skills in individuals with TBI. |
HELEN GENOVA; | 2019-12-12 |
| 426 | Detection and Amelioration of Gamma Oscillation Abnormalities in Blast-Related Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Combat Veterans of post-9/11 conflicts have experienced serious cognitive and emotional problems resulting from exposure to blasts. Recent work suggests that a critical factor influencing the consequences of blast exposure is distance from the blast, rather than the presence or absence of concussion symptoms. Exposure to blasts from a distance of \<10 m has been associated with significantly greater cognitive and neural problems than exposure to blasts from \>10 m. So far, the effects of blast-related brain injury on the brain are poorly understood, … |
KEVIN M. SPENCER; | 2019-12-02 |
| 427 | Acute and Mild Traumatic Brain Injury in A Military (and Civilian) Population Using Advanced Microstructure Imaging in Novel Ultra-High Performance MRI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective longitudinal study of patients with acute mTBI and comparison with chronic mTBI patients and a cohort without history of TBI or none within 5 years of enrollment. The patients will be recruited from the eligible population at military medical centers in the National Capital Region. |
VINCENT B HO; | 2019-11-08 |
| 428 | Neuromuscular Blockade in The Intentive Care Unit, An Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis. (Limit: 5000 characters) Neuromuscular blocking agents (NMBAs) are drug capable of inducing a complete paralysis of the muscle. Their use is frequent in the intensive care unit (ICU). Most of the time it is used as a single infusion to facilitate endotracheal intubation, but in the ICU the use of continuous infusion is common in several pathologies: acute distress respiratory syndrome, post-cardiac arrest survivor under hypothermia to prevent shivering, abdominal compartment syndrome, … |
FRENCH SOCIETY FOR INTENSIVE CARE | 2019-11-02 |
| 429 | A Sleep Intervention to Improve Rehabilitation in Veterans With Chronic MTBI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is a major cause of disability in the Veteran population, often resulting in chronic pain and sleep disturbances, among other issues. Extensive rehabilitative efforts are usually required and often prevent return to the workforce and community. Disturbed sleep and excessive daytime sleepiness are among the most pervasive and enduring problems after TBI, which the investigators hypothesize is a significant contributor to these functional impairments and an impediment toward rehabilitation. Thus, … |
JONATHAN E ELLIOTT; | 2019-11-01 |
| 430 | Theta Burst Stimulation for Headaches After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate if theta burst stimulation (TBS) can reduce chronic headaches caused by a traumatic brain injury (TBI). TBS is a safe, drug-free brain stimulation technique that uses magnets to create electricity and stimulate nerve cells in the brain. After repeated TBS sessions, the increased stimulation of nerve cells can alter the way the brain communicates with itself (by creating new neural pathways) which, in turn, … |
CRISTINA SOPHIA ALBOTT; | 2019-11-01 |
| 431 | A Preliminary Study on Irony Comprehension Ability of Chinese Speaking Patients With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims at understanding irony comprehension ability of Chinese speaking patients with TBI through a series of self-made stories. Each story contains two characters having a conversation, and one of them would give a figurative (which is, ironic) or literal statement at the end of the story. The participants are asked to figure out its meaning. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2019-10-10 |
| 432 | Usefulness of Biomarkers in The Management of Mild Traumatic Brain Injury in Adults PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The indication of cranial computed tomography (CCT) is difficult to define for patients with mild traumatic brain injury (mTBI). For mTBI patients with a medium risk of intracranial complications, CCT scans are indicated although 90% of them are normal. The interest of the S100B protein has been widely demonstrated in the management of mTBI in adults. Its serum concentration (for blood sampling drawn less than 3 hours after trauma) can accurately predict a normal CCT scan for mTBI patients with a medium risk of intracranial complications. That’s why, … |
DAMIEN BOUVIER; | 2019-10-02 |
| 433 | Coagulopathy on The First Postoperative Day Predicts The Long-term Survival of Traumatic Brain Injury Patients: A Retrospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to identify the relationship between coagulopathy during the perioperative period (before the operation and on the first day after the operation) and the long-term survival of traumatic brain injury patients undergoing surgery, as well as to explore the predisposing risk factors that may cause perioperative coagulopathy. |
TANG DU HOSPITAL | 2019-10-01 |
| 434 | Improving Time-Based Prospective Memory in TBI: A Feasibility and Dosing Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research aims to test aspects of a computer-based cognitive rehabilitation program designed to improve thinking skills in individuals with traumatic brain injury (TBI). |
ERICA WEBER; | 2019-10-01 |
| 435 | Traumatic Brain Injury Associated Radiological Deep Venous Thrombosis Incidence and Significance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Whilst deep vein thrombosis (DVT) is common following traumatic brain injury (TBI), optimal timing and safety of pharmacological prophylaxis is uncertain. Paradoxically the harm associated with the occurrence of is also unclear. This study is an observational pilot that aims to define the incidence of proximal DVT in patients with moderate to severe TBI. It seeks prospectively to determine if there is an association between DVT and outcome. It also seeks to explore possible associations between the occurrence of DVT and the incidence of lung injury and/or ventilator associated pneumonia. |
JONATHAN RHODES; | 2019-09-28 |
| 436 | Mild Head Injury and Oral Anticoagulants: A Prospective Observational Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Approximately 20% of patients with mild head injury presenting to the Emergency Department (ED) is taking antiplatelet agents and 10% is taking oral anticoagulants. The aim of the study is to determine the prevalence of cerebral hemorrhage in patients presenting to the ED with an MHI. It also aims to determine whether the use of antiplatelet agents and anticoagulants may be a risk factor for the occurrence of cerebral hemorrhage and mortality. This is a prospective observational study that will include all patients who present to ED at Gemelli Hospital for an MHI for 2 years. Patients will be divided into four groups according to whether or not they are taking anticoagulants and antiplatelet drugs. Groups will be compared to evaluate the possible increased risk of complications in patients on treatment and among the different medications. |
CANDELLI MARCELLO; | 2019-09-27 |
| 437 | The Use of The Exoskeleton Robotic Device in The Rehabilitation of Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Traumatic brain injury (TBI) is one of the leading causes of disability in the United States. The EKSO GT Bionics® (EKSO®) is a robotic exoskeleton approved by the Federal Drug Administration (FDA) for rehabilitation following a cerebrovascular accident (CVA or stroke) and recently received approval for use in patients with TBI. The aim of the study was to examine if the use of exoskeleton rehabilitation in patients with TBI will produce beneficial outcomes. Methods: This retrospective chart-review reports the use of the (EKSO®) robotic device in the rehabilitation of patients with TBI compared to patients with CVA. The investigators utilized data from a single, private rehabilitation hospital for patients that received post-CVA or post-TBI robotic exoskeleton intervention. All patients that used the exoskeleton were discharged from the hospital between 01/01/2017 to 04/30/2020. Ninety-four percent (94%) of patients in the CVA groups and 100% of patients in the TBI group were of Hispanic or Latino ethnicity. Gains in total Functional Independence Measure (FIM), walking and cognition, and length of stay in the rehabilitation facility were measured. Results: Patients in the TBI group (n=11) were significantly younger than the patients in the CVA group (n=66; p< 0.05). Both groups spent a similar amount of time active, number of steps taken, and the number of sessions in the exoskeleton. Both groups also started with similar admission FIM scores. The FIM gain in the TBI group was similar to that of the CVA group (37.5 and 32.0 respectively). The length of stay between groups was not different either. Conclusions: The use of exoskeleton rehabilitation in patients with TBI appear to produce similar outcomes as for patients with CVA, prompting further attention of this intervention for this type of injury. |
LISA TREVINO; | 2019-09-25 |
| 438 | The Effect of Remote Ischemic Conditioning (RIC) on Inflammatory Biomarkers and Outcomes in Patients With TBI Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is a leading cause of death among trauma patients accounting for one-third of all trauma mortalities. Patients who survive the initial trauma are liable to secondary insults from the ensuing inflammatory state in the brain. Treatment goals are aimed at reducing secondary injury. Maintaining adequate brain perfusion, limiting cerebral edema, … |
BELLAL JOSEPH; | 2019-09-24 |
| 439 | The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to observe the relationship between the level of lipid peroxidation products in serum of patients with traumatic brain injury and secondary coagulation disorders. |
WENXING CUI; | 2019-09-21 |
| 440 | Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Investigate The Efficacy and Safety of NT 201 in The Treatment of Lower Limb Spasticity Caused By Stroke or Traumatic Brain Injury in Adult Subjects, Followed By An Open Label Extension With or Without Combined Upper Limb Treatment PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether a single treatment with administration of 400 Units NT 201 (botulinum toxin) is superior to placebo (no medicine) for the treatment of lower limb spasticity caused by stroke or traumatic brain injury (Main Period). Participants will be assigned to the treatment groups by chance and neither the participants nor the research staff who interact with them will know the allocation. The following 4 to 5 treatment cycles will investigate the safety and tolerability of treatment with NT 201 (botulinum toxin) when administered in doses between 400 and 800 Units (Open Label Extension Period). All participants will receive the treatment and the dose will depend on whether only lower limb spasticity or combined upper and lower limb spasticity are treated. |
MERZ PHARMACEUTICALS | 2019-09-16 |
| 441 | Telephone Delivery of Cognitively Augmented Behavioral Activation (CABA) for Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is highly prevalent and frequently comorbid among Veterans and Service Members. Many of these individuals sustain more than one TBI over the course of their military careers, often with little recovery time between exposures placing them at increased risk for persistent cognitive, psychological, and psychosocial difficulties that impact daily functioning and life satisfaction. The short-term objective of this study is to examine the efficacy of the manualized, 10-week, … |
MEGAN CALLAHAN; | 2019-09-15 |
| 442 | The Effect of A Self-Monitoring Shopping Intervention for Adults With Intellectual Disability Secondary to Down Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the effectiveness of a self-monitoring intervention to improve shopping performance in adults with intellectual disability (ID) secondary to Down syndrome (DS). The research question asks, can an 8-week self-monitoring intervention, provided in a community-based setting, increase observable shopping skills in adults with ID secondary to DS? |
SHARON GUTMAN; | 2019-09-06 |
| 443 | Implementation Fidelity and Benefits of The Critical Care Pediatric Guideline Adherence and Outcomes Program in Traumatic Brain Injury PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Pediatric traumatic brain injury (TBI) is the leading killer of children worldwide but effective treatments for TBI are limited. Although evidenced-based pediatric TBI guidelines exist, adherence to these guidelines is low,leading us to develop a new Pediatric Guideline Adherence and Outcomes (PEGASUS) program to increase TBI guideline adherence. We propose to test the PEGASUS program’s ability to improve TBI guideline adherence and outcomes. |
MONICA VAVILALA; | 2019-09-01 |
| 444 | Aquatic Therapy During Post-acute Intensive Neurorehabilitation in Patients With Severe Traumatic Brain Injury: A Preliminary Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) is an acquired insult to the brain from an external mechanical force. It is considered a major cause of mortality and of long-term disabilities in young adults, especially considering high-income countries. The TBI can cause a wide range of temporary and/or permanent brain’s dysfunctions that can involve physical, cognitive, behavioural and emotional functioning limiting everyday life and social activities and leading to a lowers quality of life. a sequential preparatory approach (SPA), performed in aquatic environment, … |
MARCO TRAMONTANO; | 2019-09-01 |
| 445 | Traumatic Acute Subdural Haematoma: Management and Outcome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic acute subdural haematomas (ASDHs) are common pathological entity in neurosurgical practice . The frequency of (ASDHs) has been proposed as approximately 10-20% of patients admitted with traumatic brain injury(TBI) .Approximately two -thirds of patient with TBI undergoing emergency cranial surgery have an acute subdural haematoma evacuated . Two common causes of traumatic ASDH: accumulation of blood around parenchymal laceration , usually frontal and temporal lobes and there is usually severe underlying brain injury .The second cause is surface or bridging vessel torn from cerebral acceleration – deceleration during violent head motion . |
MOHAMED AHMED IBRAHIM ALGHRIANY; | 2019-09-01 |
| 446 | Prospective Analysis of The Use of N-Acetylcysteine and Vitamins in The Treatment of TBI in Geriatric Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the administration of N-Acetyl-cysteine in combination with multi-vitamins/minerals in geriatric population (>60 years of age) who have experienced a traumatic brain injury. |
RYAB MCPHERSON; | 2019-09-01 |
| 447 | Efficacy of Neurostimulation on Opiate Withdrawal Symptoms in Pediatric ICU Patients Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective pilot study to investigate the effects of Percutaneous Electrical Nerve Field Stimulation (PENFS) on symptoms of opioid withdrawal in pediatric patients in the intensive care unit. |
KAREN MARCDANTE; | 2019-09-01 |
| 448 | Antisecretory Factor, Administered As An Enriched Egg Powder, Salovum®, As Supplementary Therapy for Primary Glioblastoma During Concomitant Radio-chemotherapy Related Papers Related Patents Related Grants Related Experts View Highlight: This is a non-randomised, open-label, single center-centre, Phase I-II study in patients with newly diagnosed glioblastoma. 5 patients with newly diagnosed glioblastoma are enrolled in the study and will receive an egg powder enriched for antisecretory factor (AF), Salovum, daily from 2 days before concomitant radio-chemo therapy until 14 days after finalisation.The primary aim of the study is to asses safety and feasibility of this regimen. |
PETER SIESJÖ; | 2019-09-01 |
| 449 | Brain Oxygen Optimization in Severe TBI (BOOST3): A Comparative Effectiveness Study to Test The Efficacy of A Prescribed Treatment Protocol Based on Monitoring The Partial Pressure of Brain Tissue Oxygen PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In both strategies the monitoring and goals help doctors adjust treatments including the kinds and doses of medications and the amount of intravenous fluids given, ventilator (breathing machine) settings, need for blood transfusions, and other medical care. The results of this study will help doctors discover if one of these methods is more safe and effective. |
WILLIAM BARSAN; | 2019-08-28 |
| 450 | Cortical Spreading Depolarization After Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring neurosurgical intervention. |
SAMUEL CRAMER; | 2019-08-14 |
| 451 | The Impact of Accidental Hypothermia on Mortality in Trauma Patients Overall and Patients With Traumatic Brain Injury Specifically: A Systematic Review and Meta-Analysis PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a systematic literature review and meta-analysis investigating the effect of accidental hypothermia on mortality in trauma patients overall and patients with TBI specifically. Literature search will be performed using the Ovid Medline/PubMed database. Studies comparing the effect of hypothermia vs. normothermia at hospital admission on in-hospital mortality will be included in meta-analysis. |
TOBIAS HALTMEIER; | 2019-08-12 |
| 452 | A Prospective Clinical Study of Biomarkers of Mild Traumatic BRAIN Injury PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with mild traumatic brain injury (mTBI) represent a burden of patients admitted to the emergency department. According to the guidelines, a cerebral CT scan is indicated after mTBI according to the specific conditions. However, variability exists regarding the respect of these CT scan indications, and less than 10% of patients will have visible brain lesions on CT scan. Recently, … |
UNIVERSITY HOSPITAL GRENOBLE | 2019-08-10 |
| 453 | Cerebrovascular Reactivity (CVR) Assessed With Functional Near Infrared Spectroscopy (fNIRS) As A Biomarker of Traumatic Cerebrovascular Injury (TCVI) Measured Longitudinally After Acute TBI in Military Personnel PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study includes people who have recently had a traumatic brain injury (TBI) and healthy controls who have not had a TBI and is designed to measure brain blood flow serially after a TBI. Studies have shown that small blood vessels in the brain may be injured during a TBI. The goal is to learn about brain blood vessel function from as early as the first week to 6 months after a TBI . The study uses Near Infrared Spectroscopy (NIRS) which uses small lights that detect oxygen levels in the blood, … |
KIMBRA KENNEY; | 2019-08-09 |
| 454 | Transcranial Photobiomodulation to Improve Cognition in TBI, With Pre-/Post- FMRI Scans: A Pilot, Sham-Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this small, research study is to examine effectiveness of an at-home application of an experimental intervention, on thinking and memory in mild-moderate, closed-head, traumatic brain injury cases. The experimental intervention is light-emitting diode (LED) therapy, which is applied to the scalp and through the nose using a head frame device. Participants are expected to complete two, 5-week series of LED treatments, at home, 3 times a week. There will be a 1-month period between the two series. Each home treatment is 20 minutes. Participants will be trained to use the head frame device, … |
PAULA I MARTIN; | 2019-08-07 |
| 455 | Determinants of Rehabilitation Outcomes in Survivors of Primary Subarachnoid PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A retrospective, observational single centre study of electronic medical records of discharged patients who were admitted to from 1 January 2015 to 31 December 2018. Period of data collection was from 5 August 2019 to 15 September 2019. |
KAREN S CHUA; | 2019-08-06 |
| 456 | ONe Year Follow-up in Patients Admitted for Emergency Coronary Angiography After Rescuscited Cardiac Arrest PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: While 80 % of all sudden cardiac death (SCD) result from coronary artery disease (CHD) approximatively 2/3 of SCD occur as a first manifestation of the CHD. VF (ventricular fibrillation) is the main cause of SCD in acute coronary syndrome (ACS), and the 2017 ESC Guidelines for the management of acute myocardial infarction, recommended direct admission to the catheterization laboratory in survivors of out of hospital cardiac arrest (OHCA) with criteria for STEMI on the post-resuscitation electrocardiogram (ECG) (Class I, grade B). However, During the past few years, … |
UNIVERSITY HOSPITAL MONTPELLIER | 2019-08-01 |
| 457 | Dysautonomia and Systemic Interactions in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Following brain injury, complex interactions between the nervous system and other organs are frequently encountered. Systemic effects may be induced by dysregulation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. In this observational study we aim to investigate the link between clinical, physiological and biochemical expressions of dysautonomic reactions and physiological stress, and their relations to sympathetic activation in traumatic brain injury patients treated in the neurointensive care unit. |
DAVID NELSON; | 2019-08-01 |
| 458 | The Long-term Consequences After Traumatic Brain Injury in The Elderly: A Prospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A better understanding of the injury patterns, injury severity, risk profiles, consequences and impact of Traumatic Brain Injury (TBI) in the elderly population is necessary due to the increasing incidence and prevalence of TBI in this population and its high economic impact on society. Therefore, this study aims at describing the long-term consequences of TBI. In order to achieve that goal, injury patterns, injury severity and risk profiles for TBI in the elderly will be mapped. Moreover, a retrospective assessment of brain damage, co-morbidities and post-traumatic history, … |
BART DEPREITERE; | 2019-08-01 |
| 459 | A Pilot Dual-Task Treadmill Training to Improve Gait and Balance in Fragile X-Associated Tremor/Ataxia Syndrome Related Papers Related Patents Related Grants Related Experts View Highlight: A pilot trial to determine the feasibility of treadmill training with dual training in patients with Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). |
JOAN A O’KEEFE; | 2019-07-30 |
| 460 | The Impact of Traumatic Brain Injury in The Elderly: A Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A better understanding of the impact of Traumatic Brain Injury (TBI) in the elderly, in terms of brain damage, cognitive and motor functions, sleep quality and quality of life is necessary due to the increasing incidence and prevalence of TBI in this population and its high economic impact on society. Therefore, this study aims at describing the short-term consequences of TBI by studying injury patterns, injury severity, risk profiles, brain damage, co-morbidities, post-traumatic history, level of dependency, serum-based injury biomarkers, cognitive and motor functions, … |
BART DEPREITERE; | 2019-07-29 |
| 461 | Use of Facial Feature to Objectively Diagnose and Monitor Treatment of Light Sensitivity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light. |
RANDY KARDON; | 2019-07-11 |
| 462 | Safety and Feasibility of Ketogenic Diet for Traumatic Brain Injury Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic Brain Injury is a major health concern in United States. There is a un-met need to develop new therapeutic options for faster neuron recovery without causing significant side effects. The role of ketones in neuronal recovery has been studied and has been found to be useful in decreasing size of contusion. The present study aims to study the safety and feasibility profile of ketogenic diet. |
NIRAJ ARORA; | 2019-07-04 |
| 463 | Investigation of The Behavioral Signs of Consciousness Recovery in Patients With Disorders of Consciousness (DOCSIGNS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Precise description of behavioral signs denoting transition from unresponsive wakefulness syndrome/vegetative state (UWS/VS) to minimally conscious state (MCS) or emergence from MCS after severe brain injury is crucial for prognostic purposes. A few studies have attempted this goal but involved either non-standardized instruments, limited temporal accuracy or samples, or focused on (sub)acute patients. The objective of this study is to describe the behavioral signs that led to a change of diagnosis, as well as the factors influencing this transition, in a large sample of patients with chronic disorders of consciousness after severe brain injury. |
ENRIQUE NOE; | 2019-07-01 |
| 464 | The Use of Bispectral Index Monitoring to Assess Depth of Sedation in Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An observational study to assess the BIS reported level of sedation of patients with traumatic brain injury in the ICU. |
UNIVERSITY OF ABERDEEN | 2019-07-01 |
| 465 | A Randomized, Sham-controlled, Double-blinded Study of Bilateral Prefrontal Individual Connectome-targeted Repetitive Transcranial Magnetic Stimulation to Treat The Symptoms of Depression Associated With Concussive Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the efficacy and tolerability of fMRI-targeted repetitive transcranial magnetic stimulation (rTMS) in the treatment of depressive symptoms in service members with a history of concussive traumatic brain injury (TBI). Up to ninety participants will be randomized to active or sham treatment. Participants randomized into the active group will receive 20 sessions of left-sided dorsolateral prefrontal cortex (DLFPC) high-frequency rTMS, followed by right-sided DLFPC low-frequency rTMS. The DLPFC treatment area will be identified by using individual subject-level resting state network estimation (Hacker et al., … |
DAVID L BRODY; | 2019-07-01 |
| 466 | Prognostic Factors for Sequelae in Children With A History of Shaken Baby Syndrome in The Central Region Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational, prognostic and prospective study. It is about the Prognostic Factors for sequelae in children with a history of Shaken Baby Syndrome (SBS) in the Central region in France. The study hypothesis is the prognosis of the sequelae children develop according to the severity criteria presents in admission to the hospital for the Shaken Baby Syndrome. The severity criteria are clinical high intracranial pressure, presence of a coma, vitreous hemorrhage, an age under 6 months, other cerebral lesion than subdural hematoma (parenchymal lesion, … |
UNIVERSITY HOSPITAL TOURS | 2019-06-28 |
| 467 | Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose is, in patients with aneurysmal subarachnoid haemorrhage in the early phase after ictus, to examine the following: 1. The effect of spontaneous and induced changes on the brain’s static and dynamic autoregulation calculated by transcranial Doppler (TCD), ICP and MAP (primary purposes) and ICP and PbtO2; 2. The effect of mild hyper- and hypocapnia as well as of mild hyper- and hypoxia on the brain’s static and dynamic autoregulation, ICP and PbtO2; 3. The relationship between brain autoregulation, mild hyper- and hypocapnia, as well as of mild hyper- … |
MARKUS HARBOE OLSEN; | 2019-06-15 |
| 468 | RECONsolidation of Traumatic Memories to ResOLve Post Traumatic Stress Disorder (RECONTROLPTSD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Posttraumatic Stress Disorder (PTSD) is a common cause of morbidity in combat veterans, but current treatments are often inadequate. Reconsolidation of Traumatic Memories (RTM) is a novel treatment that seeks to alter key aspects of the target memory (e.g., color, clarity, speed, distance, perspective) to make it less impactful, and reduce nightmares, flashbacks, and other features of PTSD. The memory is reviewed in the context of an imaginal movie theater, presenting a fast (\~45 sec) black and white movie of the trauma memory, … |
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES | 2019-06-12 |
| 469 | Active Injury Management (AIM) After Pediatric Concussion PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed interventions of this study will determine the ideal discharge recommendations related to activity |
DANNY THOMAS; | 2019-06-11 |
| 470 | Cerebral Protection of Dexmedetomidine Against Paroxysmal Sympathetic Overexcited in Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate whether dexmedetomidine could suppress catecholamine release into peripheral blood to prevent PSH attacks and to achieve neuroprotection. |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2019-06-06 |
| 471 | Admission Hyperglycemia in Patients With Moderate to Severe Thoracoabdominal Injuries Is Associated With Higher Mortality Rate Than Non-Diabetic Normoglycemic Patients PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to measure the effects of SIH and DH on the mortality outcomes of the adult patients with moderate to severe thoracoabdominal injury |
CHANG GUNG MEMORIAL HOSPITAL | 2019-06-03 |
| 472 | Comparison of Standard Monitoring and Plethysmographic Variability Index-Guided Fluid Therapy In Severe Traumatic Brain Injury Patients Scheduled for Emergency Craniotomies: A Randomised Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized control trial aims to assess if Plethysmographic Variability Index (PVI)-based therapy improves patient outcome in terms of reduced amount and type of fluid used, lower postoperative lactate levels, lesser increment in sodium and chloride levels, improvement of blood gases in term of pH and BE, and reduction in serum creatinine as compared to standard monitoring based therapy in patients with severe traumatic brain injury. |
RADHA RAMANATHAN; | 2019-05-29 |
| 473 | Study of Effect of Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Supplementation on Biomarkers of Sub-Concussion Injuries in American Football PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football athletes. |
FLOYD CHILTON; | 2019-05-28 |
| 474 | Efficacy and Safety of 72-hour Infusion of Prostacyclin (1 Nanogram(ng)/Kilogram(kg)/Minute(Min)) in Trauma Patients With Haemorrhagic Shock Induced Endotheliopathy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A multicenter, randomized (1:1, iloprost: placebo), placebo controlled, blinded, investigator-initiated phase 2b trial in trauma patients with haemorrhagic shock and shock induced endotheliopathy (SHINE), investigating the efficacy and safety of continuous intravenous administrating of iloprost (1 ng/kg/min) versus placebo for 72-hours, in a total of 220 patients. The study hypothesis is that iloprost may be beneficial as an endothelial rescue treatment as it is anticipated to deactivate the endothelium and restore vascular integrity in trauma patients with haemorrhagic shock (SHINE) suffering from organ failure caused by endothelial breakdown, ultimately improving survival. |
PÄR JOHANSSON; | 2019-05-22 |
| 475 | Characterization & Treatment of Chronic Pain After Moderate to Severe Traumatic Brain Injury PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a five year multi-site, cross sectional, observational study designed to examine chronic pain and pain treatment after moderate to severe TBI. |
CYNTHIA HARRISON-FELIX; | 2019-05-20 |
| 476 | Cognition and Psychotherapy in PTSD: Mechanisms and Functional Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Posttraumatic stress disorder (PTSD) is prevalent among combat Veterans and is a substantial public health burden. Several psychotherapies, including cognitive processing therapy (CPT) and prolonged exposure therapy, have been recommended as efficacious for the treatment of PTSD and are being disseminated nationally in the VA Healthcare System. Yet many individuals show limited benefit from such treatments. Accumulating evidence indicates that episodic memory deficits may be one factor limiting psychotherapy treatment efficacy in PTSD. The proposed study will determine whether verbal memory is a specific predictor of CPT outcomes in PTSD, … |
JAMES C. SCOTT; | 2019-05-20 |
| 477 | Biochemical Makers for Outcome Prognostication After Pediatric Out-of Hospital Cardiac Arrest: Observational Cohort Trial Related Papers Related Patents Related Grants Related Experts View Highlight: This single-center study will validate serum, imaging and clinical markers to determine outcome of pediatric patients early after Out-of-Hospital cardiac arrest (OHCA). Results are expected to add to the field of postresuscitation care of these children. The validation of markers will provide clinicians with the tools to assess the severity of neurological impairment after hypoxic injury to the brain early after OHCA. |
PETR ŠTOURAČ; | 2019-05-17 |
| 478 | Predicting Postoperative Delirium Using Intraoperative EEG Alpha Wave Analysis, APOE Genotyping and NfL As A Biomarker of Cerebral Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this research project is to elucidate underlying pathophysiological mechanisms of postoperative delirium (POD) and to specifically validate perioperative predictive factors that will help in indentifying patients at higher risk of developing POD. 1. The main objective is to evaluate whether intraoperative frontal alpha power in unprocessed electroencephalogram (EEG), under general anesthesia, is associated with the occurrence of POD, and whether specific patterns worrelate with the patient’s preoperative cognitive status. 2. As apolipoprotein E (APOE) polymorphism has been shown to be a risk factor of POD, … |
MONA MOMENI; | 2019-05-15 |
| 479 | Assessment Role of Mgso4 As Neuroprotective in Post Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess the potential role of magnesium sulphate (MgSo4) as a neuroprotective agent using the Glasgow outcome scale following moderate and severe traumatic brain injury. |
OSAMA MOHAMED ABDELWAHAB; | 2019-05-02 |
| 480 | Trans-spinal Electrical Stimulation to Restore Upper Extremity Functions in Individuals With Traumatic Brain Injury (TBI) or Spinal Cord Injury (SCI) Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this research study is to find the efficacy of trans-spinal electrical stimulation, a non-invasive neurostimulation method to modulate the functions of spinal cord neurocircuits, on improving upper-extremity functions such as reaching and grasping in individuals suffering with traumatic brain injury (TBI) or cervical spinal cord injury (SCI); and to find the physiological changes in the neuromuscular systems after this new intervention with high-resolution electrophysiology and biomedical imaging. |
MONZURUL ALAM; | 2019-05-01 |
| 481 | From The Brain to The Bugs: Evolution of Oropharyngeal and Rectal Microbiota of Patients With Severe Traumatic Brain Injury Admitted in ICU PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Modifications of the human gut microbiota have been associated with different pathological conditions such as obesity, inflammatory bowel diseases and neurodegenerative diseases. Recently the Brain-Gut Axis , a bidirectional communication axis between brain and gut, has been described. In recent animal studies, an acute brain injury was associated with rapid modifications of the gut microbiota. In humans, traumatic brain injury (TBI) is a leading cause of death and disability. The patterns of gut and oropharyngeal microbiota following TBI are unknown. The primary purpose of this study is to characterize gut and oropharyngeal microbiota of patients with severe TBI. |
SAMY FIGUEIREDO; | 2019-04-21 |
| 482 | Defining The Operating Characteristics of Near-Infrared Spectroscopy (NIRS) in The Diagnosis of Pediatric Traumatic Intracranial Hemorrhage PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, investigators look at a different type of technology that might help to avoid having to perform CT scans in certain patients suspected of having a head injury. Near-infrared spectroscopy (NIRS) uses a specific light wavelength to determine if there is bleeding into the head as a result of trauma. Investigators will study NIRS, using a device called the Infrascanner model 2000, to determine if it is as good at detecting bleeding in the head as CT scan, … |
SHOBHAN VACHHRAJANI; | 2019-04-15 |
| 483 | Evaluation The Effects of French Maritime Pine Bark Extract Supplementation on The Inflammatory Biomarkers, Nutritional and Clinical Status in Traumatic Brain Injury Patients, in Intensive Care Unit; A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Traumatic brain injury (TBI) is one of the major health and socioeconomic problems in the world. Immune-enhancing enteral formula has been proven to significantly reduce infection rate in TBI patient. One of the ingredients that can be used in immunonutrition formulas to reduce inflammation and oxidative stress is French maritime pine bark extract. Objective: The main objective of present study is surveying the effect of French maritime pine bark extract on the clinical, nutritional and inflammatory status of TBI patients as the first human study in the world. Method: this is double-blind, … |
MAHSA MALEKAHMADI; | 2019-04-14 |
| 484 | The Role of Hyperbaric Oxygen and Neuropsychological Therapy in Cognitive Function Following Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic brain injury (TBI) caused by accidents is a very important public health problem in Taiwan. There are many people with brain damage and cognitive dysfunction caused by traumatic brain injury every year. Currently, there is no effective treatment for cognitive dysfunction caused by traumatic brain injury. Evidence from clinical studies in recent years suggests that hyperbaric oxygen therapy may be a treatment for repairing nerves after brain injury. Many studies have shown that oxidative stress and inflammatory responses play an important role in the pathogenesis of the central nervous system. In recent years, … |
HUNG-CHEN WANG; | 2019-04-09 |
| 485 | Comparison Between The IMPACT’s Score and The Clinician’s Perception to Predict The Prognosis of Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Main objective : To compare the quality of the prognostic assessment, (adverse evolution at 6 months) of severe and moderate traumatic brain injury, performed by the clinician compared to the prognosis described by the IMPACT score. The Pitié-Salpêtrière hospital is conducting a study evaluating the clinician’s prognostic assessment of severe and moderate traumatic brain injury compared to the prognosis described by the IMPACT score. The investigators compare the quality of the clinician’s prognostic assessment (adverse evolution at 6 months) of severe and moderate traumatic brain injury to the prognosis described by the IMPACT score. |
RÉMY BERNARD; | 2019-04-04 |
| 486 | Cervico-vestibular Rehabilitation for Mild Traumatic Brain Injury – A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Neck pain, dizziness and headache are common symptoms following mild traumatic brain injury (mTBI). The efficacy of cervical spine and vestibular-ocular system impairments intervention need to be determined. In this randomized clinical trial, a 6-week personalized clinical rehabilitation program on subacute mTBI will be compare to a conventional approach. The rehabilitation program will include cervical spine exercise combined with manual therapy as well as vestibular-ocular rehabilitation. Overall symptoms will be measured by the Post-Concussion Symptoms Scale (PCSS). Disability and symptoms severity related with neck pain, headache and dizziness will also be evaluated after the treatment period and at 6-week post-treatment. |
PIERRE LANGEVIN; | 2019-04-01 |
| 487 | An Open-label Study of Safety and Effectiveness of The Portable Neuromodulation Stimulator (PoNS®) Treatment for Subjects With A Chronic Balance Deficit Due to Mild-to-moderate Traumatic Brain Injury (TBI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: – Brief Summary: Prospective, cohort, open-label study. The cohort consists of people who have a chronic balance dysfunction due to a mild to moderate traumatic brain injury (TBI). All participants will participate in a 14-week PoNS Treatment protocol – a combination of symptom specific physical exercises and repeated use of the PoNS device. Subjects who meet the initial screening entrance criteria will be scheduled for a baseline assessment to evaluate balance and gait. Subjects will then begin the PoNS Treatment program and re-perform some assessments at 2, 5 and 14 weeks evaluating their functional improvements. |
HELIUS MEDICAL | 2019-04-01 |
| 488 | CLINICAL EFFECT OF BOTULINUM TOXIN TYPE A IN THE TREATMENT OF SPASTICITY AFTER TRAUMATIC BRAIN INJURY, SPINAL CORD INJURY OR IN MULTIPLE SCLEROSIS PATIENTS: AN OBSERVATIONAL STUDY PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Spasticity has been defined as a disorder of the sensorimotor system characterized by a velocity-dependent increase in tonic stretch reflexes (muscle tone) with exaggerated tendon jerks, resulting from hyperexcitability of the stretch reflex. The treatment goal of spasticity is Medical treatment generally combines physiotherapy with medications, depending on spasticity distribution. Systemic treatments such as oral or intrathecal baclofen are generally considered in case of generalized spasticity, whereas local treatments are considered in case of focal spasticity. Local treatments such as Botulinum Toxin type A, phenol, and alcohol present several advantages, … |
ALESSIO BARICICH; | 2019-03-29 |
| 489 | Brain Targets for Alcohol Craving in Veterans With MTBI Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder. The treatment intervention is repetitive Transcranial Magnetic Stimulation (rTMS) and the goal is to reduce alcohol craving with this treatment. The study will enroll 20 Veteran participants. Half of these participants will receive real rTMS and half of the participants will receive placebo rTMS. rTMS treatment will be provided over 10 sessions that will occur once every weekday for 2 weeks. Veteran participants will then complete follow-up phone calls to further evaluate alcohol craving and other symptoms. |
AMY A HERROLD; | 2019-03-21 |
| 490 | Biopsychosocial Effect of Service Dog Training on Post-traumatic Stress (PTS) and Post Concussive Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Preliminary clinical evidence suggests that Service Members with symptoms of post-traumatic stress disorder (PTSD) or Post Traumatic Stress (PTS) who participate in the Service Dog Training Program (SDTP) report improved physical and psychological outcomes, including those with overlapping symptoms associated with traumatic brain injury (TBI) and post-concussion symptoms (PCS). This study intends to examine the psychological, social, and biological effects of learning how to train a future service dog combined with standard of care for individuals with symptoms of Post-Traumatic Stress (PTS), including those with overlapping TBI and persistent Post-Concussive Symptoms (PCS). Biological, social, … |
PAUL PASQUINA; | 2019-03-05 |
| 491 | Study of PtiO2 Variation By Body Temperature and Capnia in Severe Head Trauma Patients With Intracranial Refractory Hypertension Treated With Targeted Temperature Control PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Serious head trauma is a common and pathology and responsible of high morbidity and mortality. The major challenge, from the very first hours, is to limit cerebral ischemia by controlling secondary brain injury factors. These parameters must be integrated early in order to guide the better cerebral resuscitation. Brain monitoring is multimodal:transcranial Doppler, intracranial pressure sensor, cerebral tissue pressure in O2. In the case of refractory intracranial hypertension to well-conducted medical treatment, … |
UNIVERSITY HOSPITAL BREST | 2019-03-01 |
| 492 | Clinical Trial of The Boosting Effect of Transcranial Random Noise Stimulation (tRNS) in Cognitive Rehabilitation of Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to evaluate the effects of tRNS while undergoing computerized cognitive rehabilitation therapy to conclude if this combination of therapies would be effective for the cognitive rehabilitation of patients with acquired brain damage, such as traumatic brain injury. We want to study the therapeutic potential of tRNS to enhance the therapeutic outcome of cognitive training, studying its global effect over the rehabilitation of attention, memory and executive functions, compared to sham tRNS. |
ADRIA GARCIA ROSAS; | 2019-02-25 |
| 493 | An Open-label Study of Safety and Effectiveness of The Portable Neuromodulation Stimulator (PoNS®) Treatment for Subjects With A Chronic Balance Deficit Due to Mild-to-moderate Traumatic Brain Injury (TBI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: – Brief Summary: Prospective, cohort, open-label study. The cohort consists of people who have a chronic balance dysfunction due to a mild to moderate traumatic brain injury (TBI). All participants will participate in a 14-week PoNS Treatment protocol – a combination of symptom specific physical exercises and repeated use of the PoNS device. Subjects who meet the initial screening entrance criteria will be scheduled for a baseline assessment to evaluate balance and gait. Subjects will then begin the PoNS Treatment program and re-perform some assessments at 2, 5 and 14 weeks evaluating their functional improvements. |
HELIUS MEDICAL | 2019-02-21 |
| 494 | Brain Injury Support and Strategies for Families Impacted By Childhood TBI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the effectiveness of The Traumatic Brain Injury Positive Strategies (TIPS) program, a comprehensive educational and training resource to help families improve their knowledge and skills in supporting a child with TBI experiencing cognitive, behavioral, and social challenges. The application provides training in evidence-based support strategies with the goal of improving outcomes for children with TBI and their families. Half the participants will receive access to the TIPS program, while the other half will receive access to a different TBI related website. |
ANN GLANG; | 2019-02-13 |
| 495 | Quetiapine Augmentation of Prolonged Exposure (PE) Therapy for The Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A pilot study to evaluate feasibility for a full-scale merit application. Specifically, for veterans considering prolonged exposure (PE) therapy, following the model established by Foa et al, we need to establish safety, and feasibility of quetiapine compared to treatment as usual (TAU) which employs multiple medications commonly used for PTSD in the VA system. |
MUHAMMAD BAIG; | 2019-02-01 |
| 496 | The Effect of Transcranial Direct Current Stimulation (tDCS) on Naming Ability in Patients With Traumatic Brain Injury Induced Aphasia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate whether a tDCS-accompanied intensive naming therapy leads to a performance improvement in patients with chronic aphasia induced by a moderate TBI |
AGNES FLOEEL; | 2019-02-01 |
| 497 | Ultrasound Guided Platelet Rich Plasma Injections for Post Traumatic Greater Occipital Neuralgia: A Randomized Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized controlled trial, assessing the effect of a single platelet rich plasma (PRP) injection in post traumatic (concussive) greater occipital neuralgia. This study will compare the effects of a single PRP injection to injection with steroid and anesthetic. There will also be a third arm to the study, in which patients will receive an injection with normal saline. This study will assess the severity and frequency of headache symptoms before and after receiving the injection. |
UNIVERSITY OF CALGARY | 2019-02-01 |
| 498 | Effects of Active Virtual Reality Working Memory Retraining on Heavy Drinking Veterans With Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will establish the acceptability and feasibility of enrolling and retaining heavy drinking Veterans with mild traumatic brain injury (mTBI) in an 8-week, randomized cross-over design trial of active VR working memory retraining (WMR). This study will also seek to establish the efficacy of active VR-WMR to increase performance in executive function. |
DAVID L PENNINGTON; | 2019-02-01 |
| 499 | Assessment of Stability of Behavioral and Neural Measures of Attention Networks Across Multiple Sessions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to learn more about the stability over multiple recording sessions of brainwave activity during a computerized task that measures different types of attention. |
WILLIAM PERLSTEIN; | 2019-01-31 |
| 500 | Interest of S100B Protein for Patient Victim of Minor Traumatic Brain Injury and Treated By Antiplatelet PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: All the patients admitted in emergency department for minor traumatized cranial, with antiplatelet therapy, can be included, after checked inclusion and non inclusions criterias. If they are agree, a blood sample for the dosage of S100b will be done. No other modification of the medical care, all patients will have tomodensitometria, according with recommendations. The aim of the study is to validate the negative predictive value of S100b in this population. |
POITIERS UNIVERSITY HOSPITAL | 2019-01-17 |