Clinical Digest: Recent Clinical Trials on Tuberculosis
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Tuberculosis. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Tuberculosis
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Mycobacterium Tuberculosis Complex Cell-free DNA (Mtb-cfDNA) for The Pharmacometric Assessment of Anti-tuberculosis Treatment: A Proof-of-concept Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is a leading infectious cause of death worldwide. Current strategies for monitoring TB treatment response are culture dependent and insensitive. New methods of assessing treatment response in vivo could inform new drug development and other treatment strategies. Cell-free DNA (cfDNA) – small circulating fragments of DNA – … |
TIMOTHY SEERS; | 2025-05-01 |
| 2 | A Multicenter, Open-Label Study to Assess The Pharmacokinetics And Safety of Bimekizumab in Pubertal Children And Adolescents With Moderate to Severe Hidradenitis Suppurativa PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess the PK of bimekizumab following subcutaneous (sc) administration in study participants with moderate to severe hidradenitis suppurativa (HS) |
UCB BIOPHARMA SRL | 2025-04-30 |
| 3 | A Phase 1 Open-Label Human Vaccination and Challenge Study to Assess The Ability of Intradermal BCG TICE(R) Vaccination to Induce Protective TB Immunity Capable of Inhibiting Replication In Vivo in Healthy Human Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A nonrandomized, open-label trial will be conducted with a total of 70 healthy male and non-pregnant females, ages 18-45 years. Participants in Group A will enroll 35 participants to receive 2×10\^6 colony- forming units CFU TICE(R) BCG vaccination on Day 1 and 4×10\^6 CFU challenge on Day 181. Once enrollment has been completed in Group A, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2025-04-30 |
| 4 | A Confirmatory Trial of Adjunctive N-acetylcysteine to Prevent Post Tuberculosis Lung Disease (NAC-PTLD) – A TB SEQUEL II Substudy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate if N-acetylcysteine (NAC) works to prevent post-tuberculosis lung disease (PTLD) in patients with severe pulmonary impairment. It also aims to assess the safety of NAC. The main questions the study aims to answer are: Does NAC improve lung function (FEV1%) over 12 months in participants with pulmonary tuberculosis and baseline risk factors for PTLD? What medical issues or adverse events do participants experience while taking NAC? Researchers will compare NAC treatment to a control group to see if it can prevent PTLD when given in addition to standard TB treatment. Participants will: Take NAC (1800mg twice daily) for 6 months with standard TB treatment or receive standard TB treatment alone; Attend scheduled clinic visits for 12 months, during which they will have respiratory assessments, blood tests, and symptom monitoring; Complete quality-of-life questionnaires and provide sputum and blood samples for analysis at multiple time points. |
ROBERT WALLIS – PROFESSOR; | 2025-04-28 |
| 5 | A Pan-Ultrashort Regimen for Drug-susceptible and Drug-resistant Pulmonary Tuberculosis: A Multi-Center Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) remains a major public health issue and one of the top ten causes of death from a single infectious disease worldwide. China is among the countries with the highest TB burden, ranking third globally for total TB cases and second for drug-resistant TB cases. PAN-TB is an innovative concept in TB treatment, aiming to develop a universal regimen effective for all forms of active TB, including both drug-susceptible and drug-resistant strains. The primary goal of the PAN-TB regimen is to simplify the treatment process, reduce costs, … |
SHUIHUA LU; | 2025-04-15 |
| 6 | Rifapentine- And Moxifloxacin-Containing Short-Course Regimens for Mild Spinal Tuberculosis: A Multicenter, Randomized, Non-inferiority Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the non-inferiority in efficacy between the rifapentine- and moxifloxacin-containing short-course regimens (with rifampicin replaced by rifapentine and ethambutol replaced by moxifloxacin, while isoniazid and pyrazinamide remaining the same as the empirical regimen) and the empirical long-course regimen, so as to determine whether it is possible to shorten the treatment duration to 26 weeks for patients with mild spinal tuberculosis. |
WEI ZHAO; | 2025-04-05 |
| 7 | Sedation of Remazolam in Combination With Afentanil in Non-intubated Thoracoscopic Pulmonary Surgery: A Single-blind, Randomized, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-intubated Thoracoscopic surgery (NITS) is a newly emerging minimally invasive surgical technique in recent years . Compared with traditional intubation general anesthesia, it has the advantages of less trauma, faster recovery and fewer complications . This surgical method allows patients to perform under local anesthesia or regional block and moderate sedation, providing a physiologic ventilation method , reducing the intervention on the respiratory system and conducive to rapid postoperative recovery. The importance of sedative drugs in non-intubated thoracoscopic surgery Successful implementation of non-intubated thoracoscopic surgery requires sound regional block, airway management, … |
JIANBO WU; | 2025-04-01 |
| 8 | Investigation on The Prevalence and Etiology of Adolescent Idiopathic Scoliosis in Nanchang Region PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the prevalence and etiology of adolescent idiopathic scoliosis in the Nanchang region. Elementary and middle school students who met the inclusion criteria were included in the study and school-based scoliosis screening was conducted. Diagnosis of suspected scoliosis was determined by physical examination, Adams forward bend test, measurement of trunk rotation angle, and Standing Anteroposterior X-ray of the Spine. The prevalence of suspected scoliosis among elementary and middle school students was calculated. At the same time, the researchers kept detailed records of all costs incurred in the school screening 同时，研究人员详细记录了学校筛查中产生的所有费用。 |
WENTAO ZENG; | 2025-03-28 |
| 9 | Investigation of Postural Parameters, Physical Functions, Balance and Quality of Life in Different Hip Pathologies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is known that pelvic parameters affect physical hip functions in hip pathologies. Depending on the type and severity of hip pathologies, posture, muscle strength, balance, and pain parameters may change, thereby impacting an individual’s quality of life. This study aimed to examine the postural parameters, muscle strength, balance, quality of life, pain intensity, and pain localization of individuals with different hip pathologies, including hip osteoarthritis, hip impingement syndrome, hip labrum tear, hip dysplasia, and hip avascular necrosis. |
ESRA ATEŞ NUMANOĞLU; | 2025-03-20 |
| 10 | Understanding Psycho-socioeconomic Linkages Through An Intervention Providing Enhanced Financial and Social Support During Tuberculosis Treatment PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Tuberculosis (TB) remains an ongoing public health and socioeconomic challenge worldwide, especially in low- and middle-income countries such as Vietnam. Despite improvements in healthcare, TB still causes significant problems to those infected, especially within marginalized populations, including financial hardship, stigma, and mental health issues. This study aims to assess the effectiveness of a psycho-socioeconomic support intervention intended to improve treatment outcomes and reduce financial hardship faced by TB-affected households in Vietnam, … |
RACHEL FORSE; | 2025-03-14 |
| 11 | A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for The Treatment of Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A5409/RAD-TB is an adaptive Phase 2 randomized, controlled, open-label, dose-ranging, platform protocol to evaluate the safety and efficacy of multidrug regimens for the treatment of adults with drug-susceptible pulmonary tuberculosis (TB). A5409 hypothesizes that novel regimens for the treatment of pulmonary tuberculosis will result in superior early efficacy, as determined by longitudinal mycobacteria growth indicator tube (MGIT) liquid culture time to positivity (TTP) measurements over the first 6 weeks of treatment, and will have acceptable safety and tolerability over 8 weeks of treatment relative to standard of care \[(SOC) isoniazid/rifampicin/pyrazinamide/ethambutol (HRZE)\]. The study will run for 52 weeks, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2025-03-11 |
| 12 | Open-Label, Single-Arm Trial to Evaluate The Pharmacokinetics and Safety of Bimekizumab in Pediatric Study Participants From 2 to Less Than 18 Years of Age With Active Juvenile Idiopathic Arthritis Subtypes Enthesitis-Related Arthritis (Including Juvenile-Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess plasma bimekizumab concentrations following subcutaneous (sc) bimekizumab administration. |
UCB BIOPHARMA SRL | 2025-03-11 |
| 13 | A Phase 2 Randomized, Open-label Trial to Evaluate The Early Bactericidal Activity, Safety, Tolerability, and Dose-Response of Oral Alpibectir in Combination with Ethionamide, and with Ethionamide, Rifampicin, Pyrazinamide, and Ethambutol in Adults with Newly Diagnosed, Drug-Susceptible Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A multi-centre, randomized, open-label clinical trial. All treatments will be administered orally (PO) on days 1-14. 15 participants will be recruited into each treatment arm in two sequential cohorts. Each cohort will have participants enrolled onto the experimental regimen(s) or the standard of care (SOC; HRZE) control arm. • Cohort 1 aims to generate safety data for a higher dose of alpibectir plus ethionamide 125 mg and 250 mg (arm 1: A45E125 and arm2: A45E250). Once 5 participants have enrolled into arms 1 and 2 each, and completed 14 days of treatment, … |
GIFTY OKYERE-MANU; | 2025-03-03 |
| 14 | Evaluation of The Therapeutic Effects of Mechanically Engineered Umbilical Cord-Derived Stem Cell Exosomes on Endometrial Injury: A Prospective, Non-Randomized, Parallel-Controlled Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate if engineered mechanically umbilical cord-derived stem cell exosomes, or conventional umbilical cord -derived stem cell exosomes, can improve endometrial thickness in women with thin endometrium. The main questions it aims to answer are: Can exosomes delivered via subendometrial injection improve endometrial thickness or clinical pregnancy rates compared to PRP (platelet-rich plasma)? Are there significant differences in endometrial thickness between the two treatment groups? Researchers will compare the intervention groups, which one group receives mechanical exosomes and the other receives conventional esosomes via subendometrial injection, to the control group, … |
TANG DU HOSPITAL | 2025-02-21 |
| 15 | Peripheral Blood Single Cell-type Expression Profile of Interferon-stimulated and Other Biomarker Genes for Triage of Febrile Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Febrile illness is a common condition and it is crucial to have an early triage of patients according to various aetiologies to enable appropriate treatment. Currently, most screening/diagnostic tests target the detection of pathogens, while only a few assays aim to understand the host response, and they are mostly based on a measurement of serum proteins (e.g. CRP or procalcitonin). Recently, blood transcriptome has been explored to differentiate bacterial and viral infections. However, gene expression in blood represents a composite score of gene expression of all the component cell-types present in the sample. Here, … |
NELSON TANG; | 2025-02-01 |
| 16 | A Comparative Analysis of MGAP and GAP Trauma Scores in Predicting Prognosis for Multiple Trauma Patients: A Prospective Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this prospective cohort study is to compare the predictive accuracy of the MGAP and GAP trauma scores in determining the prognosis of multiple trauma patients admitted to the emergency department at Al-Kadhimiya Teaching Hospital, Iraq. The main questions it aims to answer are: Does the MGAP score provide a more accurate prediction of outcomes compared to the GAP score? Are there specific subgroups of trauma patients where one score demonstrates superior predictive utility over the other? Participants will: Be assessed using both the MGAP and GAP scores upon admission to the emergency department. Have their clinical outcomes, … |
ABDUL-ILAH R. KHAMIS; | 2025-01-20 |
| 17 | Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute liver failure (ALF) is a serious condition in which the liver suddenly stops working, often leading to life-threatening complications. While N-Acetylcysteine (NAC) is widely used to treat ALF caused by acetaminophen overdose, its benefits in ALF due to other causes, such as viral infections or drug reactions, remain uncertain. This study is a randomized controlled trial designed to investigate whether NAC can improve survival rates and reduce hospital stays in patients with non-acetaminophen-induced ALF. Participants will be randomly assigned to receive either NAC along with standard supportive care or standard supportive care alone. The study will measure survival rates, … |
MUHAMMAD IRFAN JAMIL; | 2025-01-15 |
| 18 | Intestinal Microbiota Transplant As A Strategy to Enhance The Resilience Capacity of The Elderly Aiming to Retain Muscular, Cognitive, and Metabolic Functions in A Stressful Environment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sarcopenia, characterized by the progressive loss of muscle mass and strength in older adults, is a key factor in health deterioration. It affects 15% of people between 65 and 80 years old and over 50% of those over 80, compromising autonomy and increasing the risk of diseases. Sarcopenia not only impacts muscle function but also bone health, mobility, and is associated with cardiometabolic diseases and cognitive decline. It has been proposed that changes in the gut microbiota in aging individuals, known as gut dysbiosis, contribute to sarcopenia. Species diversity decreases, and bacterial representation is altered, … |
GONZALO JORQUERA; | 2025-01-10 |
| 19 | Validation of The Kinshasa Lung Ultrasound Approach for The Narrowing of Differential Diagnosis in Children Admitted With Acute Respiratory Symptoms in Low-resource Settings PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study team will perform a prospective, observational study in two sites in the Democratic Republic of Congo (DRC) and Bangladesh in children aged 3 months to 14 years, admitted to hospital with acute respiratory symptoms. The Kinshasa lung ultrasound (K-LUS) approach integrates existing WHO clinical guidelines, lung ultrasound diagnostic accuracy evidence and paediatric ultrasound guidelines. The approach was built using a modified Delphi technique and integrates six LUS profiles, two clinical history features (timing of onset, trauma) and one clinical examination feature (fever) to suggest one among 10 clinical diagnosis. After the initial diagnosis is established by the treating physician, … |
LUIGI PISANI; | 2025-01-01 |
| 20 | Effect of Cırcadıan Feedıng on Growth Parameters of Preterm Newborn PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was planned as a randomized controlled experimental study to determine the effect of circadian feeding on the growth parameters of preterm newborns. The data of the study were collected from patients aged 32-34 in the Neonatal Intensive Care Unit (NICU) of Selçuk University Faculty of Medicine. It will consist of premature babies and mothers born during the first week of gestation. The sample size was planned to include 48 preterm newborns and their mothers. Mother-Preterm Introductory Information Form, Breast Milk Feeding Follow-up Form, Breast Milk Content Parameters Follow-up Form, Newborn Baby Follow-up Form, … |
AYSE SONAY TURKMEN; | 2025-01-01 |
| 21 | Rab 32 Gene Polymorphisms As A Prognostic Factor in Leprosy Patients and Its Relation to Multiple Drug Therapy: Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mycobacterium leprae is a slow-growing bacillus that causes leprosy. the infection may take two to ten years to incubate. While the exact mechanism of infection transmission is unknown, direct bacillus absorption through the nasal or respiratory mucosa and aerosolized nasal secretions are the most common theories. The bacteria is subsequently transported by the bloodstream to the peripheral nerves, where it can result in tissue damage from painless burns and ulcers as well as irreparable nerve damage that results in a loss of protective feeling. |
LYDIA ATEF NASSIEF; | 2024-12-20 |
| 22 | A Clinical Trial Evaluating The Safety of An Aerosol BCG Controlled Human Infection Model in Assessing The Immunogenicity of Historical BCG Vaccination and Vaccination With ID93/GLA-SE in Healthy Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to: 1. Demonstrate the safety of a novel TB vaccine (ID93/GLA-SE) when given to both BCG-vaccinated and BCG-naïve volunteers. 2. Provide preliminary immunogenicity data of this novel TB vaccine (ID93/GLA-SE). This clinical trial will apply an aerosol BCG challenge model involving 48 participants – 24 historically BCG-vaccinated volunteers and 24 BCG-naïve volunteers. Bronchoscopies will be performed 14 days post-challenge to measure BCG recovered from bronchial samples. Blood tests will be taken to look at potential immunological markers of immunity. |
HELEN MCSHANE; | 2024-12-18 |
| 23 | Characterization of Tuberculosis Associated Lung Fibrosis and Respiratory Impairment, and Prevention Using Doxycycline in A Double Blind Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the efficacy(effectiveness) of doxycycline, a potent inhibitor of matrix metalloproteinase (lung collagenase) activity in prevention of Tuberculosis associated lung fibrosis and associated lung function decline among patients with drug sensitive advanced TB. The main question\[s\] it aims to answer are: * Does doxycycline have a significant anti-fibrosis role when given as adjuvant therapy to TB patients with advanced pulmonary TB in a double blind randomized placebo controlled trial? * How does long term respiratory function defer between patients who received adjuvant doxycycline aimed at prevention of TB associated lung fibrosis and those who received a placebo in a double blind randomized controlled trial? Participants will be subjected to the following: * Experimental arm: Doxycycline 100 mg once daily for 12 weeks administered concurrently with standard of care anti-TBs. * Comparator arm: Placebo once daily for 12 weeks administered concurrently with standard of care anti-TBs. |
MAKERERE UNIVERSITY | 2024-12-04 |
| 24 | Observation Study on The Efficacy of Yiqi Gubiao Pill in The Treatment of Chronic Obstructive Pulmonary Disease Secondary to Active Pulmonary Tuberculosis: A Double-Blind Randomized Controlled Trial Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis-related obstructive pulmonary disease (TOPD), as a high-burden disease in most countries, poses difficulties in the diagnosis and treatment of the disease when coexisting, and increases the risk of death for patients. Preliminary studies have shown that Yiqi Gubiao Wan has significant effects in relieving cough, alleviating asthma, expectorating phlegm, and delaying airway obstruction. The purpose of this study is to verify the therapeutic effect of Yiqi Gubiao pill on patients with TOPD through rigorous methodological design and to evaluate its safety. We will conduct a prospective, double-blind, randomized controlled trial. First, … |
JIN DAI; | 2024-11-30 |
| 25 | Innovating Shorter, All- Oral, Precised Treatment Regimen for Rifampicin Resistant Tuberculosis：BDLL Chinese Cohort PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an investigational, prospective, multicenter, single-arm, open label trial. The goal of this clinical trial is to evaluate the efficacy and safety of a 6-month all-oral regimen, consisting of Bedaquiline (BDQ, B), Delamanid (DLM, D), Linezolid (LZD, L), Levofloxacin (LFX) or Clofazimine (CFZ, C), or BDLLfxC regimen, … |
WEN-HONG ZHANG; | 2024-11-27 |
| 26 | Validation and Simplification of The Retinol Isotope Dilution Technique in Burkinabe Schoolchildren PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Two cross-sectional, repeated-pass, community-based studies will be carried out during the school year. The first study will be conducted from November to December. This period corresponds to the end of the rainy season and the end of the mango season, which is one of the main sources of vitamin A in the Orodara region. The second survey will be carried out 5 to 6 months (April-May of the following year) after data collection for the first study, … |
AUGUSTIN N. ZEBA; | 2024-11-21 |
| 27 | Tuberculosis Case Finding at The Completion of The CoVPN 3008 Clinical Trial: A Substudy to CoVPN 3008 PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This substudy aims to identify cases of tuberculosis after the CoVPN 3008 clinical trial is completed. |
COVID 19 PREVENTION NETWORK | 2024-10-21 |
| 28 | Effects of Tuberculosis Infection on Placental Development and Function PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta. The main questions it aims to answer are: * Does TB infection affect the structure of the placenta? * Does TB infection affect the function of the placenta? Pregnant women attending delivery clinics in Addis Abeba, Ethiopia, … |
PER BJORKMAN; | 2024-10-01 |
| 29 | Detection of Mycobacterium Tuberculosis in Blood of TB Patients and Their Contacts in Uganda PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mycobacterium tuberculosis (Mtb) is a major human pathogen, responsible for an estimated 10.6 million cases of active tuberculosis (TB) and 1.6 million deaths in 2021. Most adult cases of active TB arise from progression of latent tuberculosis infection (LTBI), whose global prevalence is estimated at 23%. Preventive therapy (e.g. a 6-month course of the anti-TB drug isoniazid) is effective in reducing risk of progression from LTBI to active TB. Global roll-out of preventive therapy will be required to achieve the World Health Organization target of TB elimination by 2050, … |
ADRIAN MARTINEAU; | 2024-09-30 |
| 30 | Improving The Outcomes of Children with Tuberculosis Through Innovative Diagnostics and Treatment Monitoring PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investigators will use target next generation sequencing to determine if the bacillus is resistant to any of the drugs used for treatment. Additionally, children initiated under TB treatment will be followed-up during treatment to measure blood biomarkers for outcome prediction. Finally, … |
CHRISTOPH LANGE; | 2024-09-15 |
| 31 | Analysis of The Clinical Characteristics and Three Treatment Methods of Granulomatous Lobular Mastitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Granulomatous lobular mastitis (GLM) is a rare benign breast disease that is difficult to distinguish from breast cancer based on clinical and imaging findings, and there is currently no standard treatment. This study aims to analyze the clinical characteristics and demographic data of GLM patients and to compare the overall effectiveness of three treatment methods: surgery alone, triple anti-tuberculosis drug therapy alone, and combined surgery with triple anti-tuberculosis drug therapy, with the goal of providing new insights for clinical treatment. |
FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY | 2024-08-19 |
| 32 | Phase 1b/2 Study of Axatilimab (SNDX-6352) + Azacitidine (AZA) in Advanced Phase MPN, MPN/MDS Overlap or High-Risk CMML PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase Ib/II trial tests the best dose of axatilimab and effectiveness of axatilimab with or without azacitidine for the treatment of patients with advanced phase myeloproliferative neoplasms (MPN), myeloproliferative neoplasm/myelodysplastic syndrome (MPN/MDS) overlap or high risk chronic myelomonocytic leukemia (CMML). Axatilimab is an antibody that is cloned from a single white blood cell that is known to be able to recognize cancer cells and block a protein on the surface of the white blood cells that may be involved in cancer cell growth. By blocking the proteins, … |
UMA BORATE; | 2024-08-02 |
| 33 | A Randomized Controlled Trial on Exercise Program in Patients With Nontuberculous Mycobacterial Pulmonary Disease (NTM-Exercise) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1.objective Evaluation of effectiveness and safety of exercise intervention program for patients with non-tuberculous mycobacterial pulmonary disease 2. background Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic respiratory infection that generally affects individuals with structural lung diseases, such as chronic obstructive pulmonary disease (COPD) and bronchiectasis and without structural lung disease. The prevalence of NTM-PD is increasing worldwide , … |
YONSEI UNIVERSITY | 2024-07-24 |
| 34 | Analysis of Liver Injury Risk Factors in A Multiethnic Population Treated With Antituberculosis Drugs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is the world’s second leading cause of death from a single infectious agent after COVID-19. In 2022, TB was estimated to have affected 10.6 million people, of whom 1.3 million died because of it, despite the WHO’s implementation of the End TB program. Although the gold standard therapy is effective, it may lead to adverse events, among which hepatotoxicity is the most common. Due to its frequency, severity, and potential outcome, anti-TB drug-induced liver injury (DILI) is extremely concerning. Despite decades of use and the large number of patients exposed to anti-TB drugs worldwide, … |
STEFANIA CHELI; | 2024-07-05 |
| 35 | Exploration and Study on The Identification of Various Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) marker molecules. This model aims to accurately diagnose mutiple pulmonary diseases. The primary objectives it strives to accomplish are: 1. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose several common pulmonary diseases. 2. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose more pulmonary diseases. |
CHROMX HEALTH | 2024-06-30 |
| 36 | A Multicenter, Randomized, Parallel-Group, Double-Blind, Active-Controlled Study to Evaluate The Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to evaluate the efficacy of bimekizumab administered subcutaneously (sc) compared to active control (ustekinumab) in children and adolescents aged 6 to \<18 years of age with moderate to severe plaque psoriasis (PSO). |
UCB BIOPHARMA SRL | 2024-06-25 |
| 37 | Evaluating The Accuracy of New Tests for TB Infection Diagnosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: The large reservoir of tuberculosis infections is a key driver of sustained tuberculosis (TB) incidence. Accurate diagnostic tests are crucial to correctly identify and treat people with TB infection, which is vital to eliminate TB globally. The Cy-TB skin test and STANDARD F TB-Feron FIA (TB-Feron) fluorescent immunoassay are two newly developed TB infection tests, which could offer quality and cost advantages over other commercially available TB infection tests, … |
FREUNDESKREIS FÜR INTERNATIONALE TUBERKULOSEHILFE E V | 2024-06-11 |
| 38 | Preliminary Study of CXCL3 As A Biomarker of Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn about CXCL3 as a biomarker for type 2 diabetic kidney disease (DKD) in adults between age of 18-80. The main question it aims to answer is: – Is CXCL3 elevated in the serum or urine of type 2 adult DKD patients compared to normal control or diabetes mellitus without kidney involvement? – Is CXCL3 elevated in the mRNA of PBMC of type 2 adult DKD patients compared to normal control or diabetes mellitus without kidney involvement? – … |
THE FIRST HOSPITAL OF JILIN UNIVERSITY | 2024-06-10 |
| 39 | A Survey on The Practice and Interpretation of Various Diagnostic Tests for Tuberculous Pleuritis Among Respiratory Physicians PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis is a major infectious disease with a high mortality burden in the Asia-Pacific region and worldwide. Among various types of extrapulmonary tuberculosis, tuberculous pleuritis (TBP) is amongst the most common manifestations. TBP is also a major underlying cause among patients hospitalised with new-onset unilateral pleural effusion. The workup of TBP frequently involves thoracentesis to retrieve pleural fluid and pleural biopsy for microbiological and histological interpretations. However, the diagnostic accuracy of these tests is of unsatisfactory sensitivity, making diagnosing TBP challenging. In addition, certain tests, including pleural fluid adenosine deaminase (ADA), Mycobacterium tuberculosis polymerase chain reaction (MTB PCR), … |
KA PANG CHAN; | 2024-06-01 |
| 40 | HIV Infection Accompanied By Multi-Drug Resistant Tuberculosis: A Decadal Systematic Review and Meta-Analysis PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran. It will involve a detailed analysis of patient demographics, clinical characteristics, and treatment outcomes to enhance understanding of this co-infection. The findings may inform better treatment strategies and healthcare policies for managing these diseases in similar populations. |
HAMIDREZA KOUHPAYEH; | 2024-05-15 |
| 41 | Comparative Efficacy of Chest Ultrasound, Chest X-Ray and Computer-aided Diagnostic (CAD) for Tuberculosis Diagnosis in Low-Resource Setting: A Cross-Sectional Study From Ethiopia (CUSTB) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary Tuberculosis (TB) remains a significant global health concern, particularly in low- and middle-income countries (LMIC), where resources for healthcare are often limited. While CXR is the standard imaging modality for TB diagnosis, its sensitivity and specificity can vary depending on factors such as the stage of the disease and the quality of the image obtained. This study endeavors to assess the diagnostic precision of Chest Ultrasound (CUS) relative to Chest X-ray (CXR) and CAD score in the detection of Pulmonary Tuberculosis (TB) among both index cases and household contacts. |
FRANCESCO DI GENNARO; | 2024-05-05 |
| 42 | Assessment of The Prevalence and The Outcome of Prescribing Drugs Known to Have Major Drug-Drug Interactions With Anti-tuberculous Drugs Among Kasr Alainy Tuberculous Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the prevalence and the outcome of prescribing drugs known to have major drug-drug interactions with anti-tuberculous drugs among Kasr Alainy tuberculous patients. |
OMNIA AZMY NABEH; | 2024-04-30 |
| 43 | Respiratory Muscle Stretching As An Adjunct to Pulmonary Rehabilitation: Outcomes in Chest Expansion, Dyspnea, and Cough in Post-Tuberculosis Bronchiectasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study intends to examine the effectiveness of adding RMS to a traditional program of pulmonary rehabilitation regarding chest expansion, dyspnea, and cough symptoms in bronchiectasis post-tuberculosis patients. Bronchiectasis, resulting from tuberculosis treatment, is characterized by restricted chest wall motility, chronic dyspnea, and an irritating cough, factors that severely impair these patients’ quality of life. It is assumed that RMS improves the compliance of the chest wall, thereby enhancing respiratory mechanics and consequently reducing symptoms. The outcomes will be compared between two groups: one group with standard pulmonary rehabilitation and another group with additional RMS exercises. |
DIAN MARTA SARI; | 2024-04-29 |
| 44 | Comparative- and Cost-effectiveness Research Determining The Optimal Intervention for Advancing Transgender Women Living With HIV to Full Viral Suppression PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Text Me, Alexis! is a three-arm randomized controlled trial (RCT) to determine the optimal and most cost-effective intervention for advancing trans women living with HIV to full viral suppression. Participants will be randomized (1:1:1) to Peer Health Navigation (PHN) alone, SMS (text messaging) alone, or PHN+SMS. Participants in the PHN alone and PHN+SMS arms will receive unlimited navigation sessions over 3 months. Participants in the SMS alone and PHN+SMS arms will receive 3 daily theory-based text messages for 90 days for a total of 270 unique scripted messages. |
CATHY J REBACK; | 2024-04-11 |
| 45 | Evaluation of A Novel Microbiological Diagnostic Test for Latent Mycobacterium Tuberculosis Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is an infectious disease that is caused by bacteria (bugs). The infection is passed on when a patient with active lung TB coughs bugs into the air, which are then breathed in by an uninfected person. In 90% of people who get infected, the TB infection remains dormant and the person never falls ill with active TB disease. However, 10% of people with dormant TB infection will eventually go on to develop active TB disease at some time in the future, … |
QUEEN MARY UNIVERSITY OF LONDON | 2024-04-02 |
| 46 | Fecal Transplantation in Patients With Colonic Diverticulitis: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the safety and effect of fecal microbiome transplantation (FMT) in patients with a former episode of acute colonic diverticulitis. The main question[s] it aims to answer are: – Is FMT in patients with a former episode of acute colonic diverticulitis a safe procedure without severe adverse events – What is the impact of FMT on patient-reported outcomes and re-admission rate Participants will be asked to: – to ingest either 25-30 capsules with FMT or placebo capsules – Fill-in GI-QLI questionnaire prior to treatment/placebo and 3 months post baseline – … |
THOMAS BJØRSUM-MEYER; | 2024-04-01 |
| 47 | Role of Conservative Management in Adhesive Intestinal Obstruction Versus Operative Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the role of Conservative management in patients with adhesive Intestinal Obstruction Regarding the selection criteria of the patients, duration of conservative route, success rate, and recurrence of adhesions and avoiding the surgical route complications. |
OSAMA KHALED AHMED; | 2024-04-01 |
| 48 | Mobile Health and Oral Testing to Optimize Tuberculosis Contact Tracing in Colombia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall objective of this Aim is to design and iteratively adapt a home-based, mHealth- and oral testing facilitated strategy for implementing tuberculosis (TB) contact tracing in Cali, Colombia. Investigators will employ an iterative, community-engaged, participatory co-design process to optimize the feasibility, acceptability, usability, and appropriateness of the mobile health (mHealth) and oral testing strategy, in preparation for a future, appropriately powered implementation-effectiveness trial. This protocol includes the baseline contact tracing protocol and the procedures for determining adaptations to the mHealth strategy (i.e., nominal group technique). |
J. LUCIAN DAVIS; | 2024-03-28 |
| 49 | A Phase 1, Open-Label, Drug-Drug Interaction Study to Assess The Effect of TAK-279 on The Pharmacokinetics of A Sensitive CYP3A4 Substrate and A Sensitive CYP2C8 Substrate in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of this study is to find out how several doses of TAK-279 affects the body of healthy adults and processes midazolam and repaglinide (pharmacokinetics or PK). Another aim is to learn about the side effects of TAK-279 and how well it is tolerated when given to healthy adults either alone or together with midazolam or repaglinide. During the study, participants will need to stay at the clinic for 19 days. Blood samples will be taken at several timepoints during the study. The study drug will be given by mouth (orally). |
MARA BAIER; | 2024-03-26 |
| 50 | Interferon Gamma, Interleukin-10, Hematology and Microscopic Profile of Tuberculosis Patients With Treatment Combination of Anti-Tuberculosis and Butterfly Pea Flowers Extract (Clitoria Ternatea) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if butterfly pea flowers (Clitoria ternatea) decocta extract works to treat as adjuvant therapy for tuberculosis in adults. It will also learn about the safety of butterfly pea flowers decocta extract. The main questions it aims to answer are: – Does butterfly pea flower extract as an adjunct TB drug therapy drug affect the profiles of interferon gamma and interleukin-10 of people with tuberculosis? – Does butterfly pea flower extract as an adjunct TB drug therapy drug affect the hematology profiles of people with tuberculosis? – … |
MAYA DIAN RAKHMAWATIE; | 2024-03-14 |
| 51 | Gene-guided N-acetyl Cysteine for Prophylaxis of Anti-tuberculous Drug- Induced Hepatitis: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) remains a significant public health concern in Thailand and globally, especially in tropical regions, with pulmonary TB being predominant. Besides affecting the lungs, TB can also impact extrapulmonary organs. Standard TB treatment involves a combination of drugs administered for at least 6 months, but it can cause adverse effects such as hepatitis. Hepatotoxicity, occurring in 20-60% of patients, is commonly linked to isoniazid, rifampicin, and pyrazinamide. Slow acetylators of the NAT2 gene are particularly susceptible. Previous research suggests N-acetylcysteine (NAC) may mitigate hepatotoxicity, … |
WATCHARASAK CHOTIYAPUTTA; | 2024-03-12 |
| 52 | A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter, Clinical Trial to Assess The Prophylactic Efficacy, Safety, and Immunogenicity of The Investigational M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine When Administered Intramuscularly on A 0,1-month Schedule to Adolescents and Adults PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a randomized, double-blind, placebo-controlled, multicenter, clinical trial to assess the prophylactic efficacy, safety, and immunogenicity of the investigational M72/AS01E-4 Mtb vaccine when administered intramuscularly (IM) on a 0,1-month schedule to adolescents and adults. This trial will be conducted in 3 cohorts: Interferon gamma release assay (IGRA)-positive Cohort, IGRA-Negative Cohort and Human Immunodeficiency virus (HIV) Cohort. |
BILL & MELINDA GATES MEDICAL RESEARCH INSTITUTE | 2024-03-05 |
| 53 | The Effect of Stress Ball Intervention During Non-Stress Test on Anxiety and Fetal Well-Being in Women With High-risk Pregnancy: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research will be conducted to determine the effect of stress ball intervention during NST on anxiety and fetal well-being in high-risk pregnant women. Women with high-risk pregnancies randomly assigned to intervention (n=43) and control (n=43) groups at a state and a faculty hospital in Turkey will be included in the study. Pregnant women in the intervention group will be told to squeeze and release the ball once after counting to three, to inhale each time they press the ball, … |
HÜMEYRA TÜLEK DENİZ; | 2024-03-01 |
| 54 | Local Dishes Versus Ready-to-use Therapeutic Foods in The Management of Severe Acute Malnutrition During The Rehabilitation Phase: A Randomized, Single-blind Study at The Regional Hospital Annex of Mokolo (Cameroon) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In a context of frequent shortages of ready-to-use therapeutic foods (RUTFs), this study aimed at assessing the effectiveness of the use of local dishes in conjunction with nutritional education for children with severe acute malnutrition (SAM) during the rehabilitation phase. This work is based on a randomized, single-blind study. Children aged between 6 to 59 months, hospitalized for SAM and undergoing treatment during the rehabilitation phase, were included. Randomization was performed by consecutive inclusion based on: – Even numbers (control group under RUTFS) and – Odd numbers (intervention group with local dishes). |
KAMO SELANGAI HÉLÈNE; | 2024-02-29 |
| 55 | Pharmacokinetics and Safety of Double-dose Dolutegravir When Used With Rifapentine for HIV-associated Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A5406 hypothesizes that dolutegravir (DTG) 50 mg taken twice daily will provide adequate exposures to maintain viral suppression when dosed with rifapentine (RPT) 1200 mg for HIV-associated TB. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2024-02-13 |
| 56 | Phase II Clinical Study of Contezolid for The Treatment of Tuberculous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Contezolid is a novel oxazolidinone antibiotic developed by Shanghai Mengke Pharmaceutical Co., Ltd., which successfully went public in 2021. It inhibits bacterial growth by interfering with protein synthesis through its translational inhibitory effect on bacteria. Contezolid has demonstrated promising clinical results in patients with drug-resistant tuberculosis, making it a powerful tool in the fight against drug-resistant tuberculosis. Currently, there is a lack of pharmacokinetic data on contezolid in patients with central nervous system tuberculosis. Some studies have reported the steady-state concentrations of contezolid in the serum and cerebrospinal fluid (CSF) of tuberculous meningitis patients receiving multidrug therapy, … |
NIE WENJUAN; | 2024-02-01 |
| 57 | Phase II Clinical Study of Contezolid for The Treatment of Bone and Joint Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Contezolid is a novel oxazolidinone antibacterial agent that has shown promising application prospects in the field of tuberculosis treatment in recent years. Studies have demonstrated that contezolid exhibits comparable anti-tuberculosis activity to linezolid both in vitro and in vivo, and even superior intracellular bactericidal activity against Mycobacterium tuberculosis. More importantly, contezolid significantly reduces the risks of bone marrow suppression toxicity, neurotoxicity, and lactic acidosis compared to linezolid, thereby enhancing the drug’s safety and tolerability. In the treatment of bone and joint tuberculosis, contezolid, as a new anti-tuberculosis drug, holds potential significant value. Firstly, … |
NIE WENJUAN; | 2024-01-31 |
| 58 | Rapid Research in Diagnostics Development for Tuberculosis Network (R2D2 Kids) and Assessing Diagnostics At Point-of-care for Tuberculosis in Children (ADAPT for Kids) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Every year there are an estimated 230,000 childhood deaths from TB. There is an urgent need for novel tests for TB diagnosis in children under 15 years. The Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and the Assessing Diagnostics at Point-of-care for Tuberculosis in children (ADAPT for Kids) studies seek to reduce the burden of TB worldwide by evaluating faster, simpler, and less expensive TB triage and diagnostic tests for use in children. |
ADITHYA CATTAMANCHI; | 2024-01-26 |
| 59 | An Open-Labelled, Phase I Clinical Trial to Assess The Safety Reactogenicity, Tolerability and Immunogenicity of A Tuberculosis Vaccine BBV169 (MTBVAC), in Healthy Indian Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An Open-labelled, Phase I Clinical Trial to Assess the Safety, Reactogenicity, Tolerability, and Immunogenicity of MTBVAC in healthy Indian adult volunteers A total of 30 subjects with Quantiferon®-TB Gold Plus assay negative and ages 18 to 65 years will be enrolled in this trial. All the subjects will receive a single dose of MTBVAC via the intradermal route in the right deltoid region. DSMB meetings will be conducted after Day 28 , Day 90 & Day 180 after vaccinating all subjects. |
BHARAT BIOTECH INTERNATIONAL | 2024-01-19 |
| 60 | The Effects of Addition Respiratory Muscle Stretching Exercise for Improving Functional Exercise Capacity Fatigue and Quality of Life in Patients With Bronchiectasis Post-Tuberculosis Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchiectasis is a chronic condition often arising after the successful treatment of lung tuberculosis, leading to diminished functional exercise capacity, increased fatigue, and reduced quality of life. This randomized controlled trial aims to evaluate the efficacy of adding Respiratory Muscle Stretching (RMS) exercises to standard pulmonary rehabilitation in improving functional exercise capacity, reducing fatigue, and enhancing the quality of life in patients with bronchiectasis post-tuberculosis. |
DIAN MARTA SARI; | 2024-01-17 |
| 61 | The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia (A Randomized Controlled Clinical Trial With A Biochemical Assessment) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is designed to evaluate the clinical efficacy of thyme honey as a mouth rinse in the management of polypharmacy-induced xerostomia concerning the unstimulated whole salivary flow rate and quality of life of patients along with a biochemical assessment of salivary nitric oxide levels. |
NEVEN NABIL TADRY BANOUD; | 2024-01-15 |
| 62 | Safety and Efficacy of Four-month Short Course Regimen in Low Risk Active Tuberculosis- A Multicenter Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis remains an important global health problem, and the world is currently not on track to end the TB epidemic by 2030. With the concerted efforts of the government and medical community, the incidence of TB in Taiwan has gradually decreased, however, Taiwan remains an endemic area for TB. The development of efficacious, safe, and shorter treatment regimens could significantly improve treatment completion rate and reduce transmission of TB. The current treatment guidelines for drug-susceptible TB from the World Health Organization (WHO), American Thoracic Society (ATS), United States Center for Diseases Control (U.S. CDC), … |
SUSAN SHIN-JUNG LEE; | 2024-01-01 |
| 63 | A Multicenter, Randomized, Open-Label Study to Evaluate The Efficacy and Safety of A Contezolid, Delamanid and Bedaquiline-Containing Short Regimen for The Treatment of Rifampicin-Resistant Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the efficacy and safety of a Contezolid and Delamanid-Containing short regimen to standard longer regimen in Rifampicin-resistant pulmonary tuberculosis (RR-TB). The main questions it aims to answer are: * Is the efficacy of short regimen non-inferior to standard regimen? * Is the short regimen safe enough to replace the standard regimen? Participants will: * Be given with either short or standard regimen for RR-TB treatment * Be asked to complete the scheduled visit as planned. |
CHU NAIHUI; | 2023-12-22 |
| 64 | Randomized, Double-blind, Placebo-controlled Phase 2 Trial of ТВ/Flu-05Е Intranasal Vector Vaccine for The Prevention of Tuberculosis Infection in BCG-vaccinated Volunteers Aged 18-50 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate immunogenicity and safety of the TB/Flu-05E single-dose intranasal vaccine for the prevention of Tuberculosis infection in BCG-vaccinated Volunteers aged 18-50 years |
TATYANA ZUBKOVA; | 2023-12-13 |
| 65 | Value of Xpert® MTB/RIF Ultra in Cases With Suspected Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To estimate diagnostic accuracy of Xpert Ultra and Xpert MTB/RIF for extrapulmonary tuberculosis and rifampicin resistance in adults suspected to be infected with mycobacterium tuberculosis. In addition, this study will estimate the pattern of rifampicin resistance among TB cases in Assiut population. |
HEND MOHAMED SAYED MOHAMED; | 2023-12-11 |
| 66 | A Prospective, Single-arm, Open-label, Non-interventional, Multi-centre, Post Marketing Surveillance (PMS) Study of Mylotarg® PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Mylotarg) for the potential treatment of acute myeloid leukemia (AML). AML is a disease that affects the body’s white blood cells. This study is seeking participants in Korea who: * Are 18 years of age or older * Are adults and newly diagnosed with AML * Currently receive Mylotarg for AML treatment in a hospital * Are capable of a personally signed and dated informed consent document indicating that the participant (or a legally acceptable representative) has been informed of all pertinent aspects of the study. Participant’s health will be closely monitored for any unwanted reactions during Mylotarg treatment. Disease progression will also be monitored. This will help determine if Mylotarg is safe to use and its effect on AML treatment. |
PFIZER | 2023-12-05 |
| 67 | Effectiveness of Video Observed Therapy in The Management of Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to measure the effectiveness usage of VOT in the treatment of TB in terms of treatment adherence. The study will be a randomized controlled trial and will involve 240 TB patients. The study is aimed to commence by December 2023. The study period will be for 4 months. |
UNIVERSITY OF MALAYA | 2023-12-01 |
| 68 | A Phase IIc, Open-Label, Randomized Controlled Trial of Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible Tuberculosis (PRESCIENT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The PRESCIENT trial is a Phase IIc, open-label, randomized trial that will compare a 12-week regimen of bedaquiline (BDQ), clofazimine (CFZ), pyrazinamide (PZA), and delamanid (DLM) with standard treatment for drug-susceptible pulmonary tuberculosis. Eligible participants will be randomized in a 1:1 ratio to BDQ, CFZ, PZA, … |
SERENA PATRICIA KOENIG; | 2023-11-24 |
| 69 | Phase 2C Clinical Trial of Novel, Short-course Regimens for The Treatment of Pulmonary Tuberculosis: CRUSH-TB (Combination Regimens for Shortening TB Treatment) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether one or two 17-week regimens of tuberculosis treatment bedaquiline (B or BDQ), moxifloxacin (M), pyrazinamide (Z)– (BMZ) plus either Rifabutin (Rb) or Delamanid (D or DLM) are as effective as a standard six-month regimen for treatment of pulmonary tuberculosis (TB). All three regimens are administered daily, seven days each week. The first 17-week regimen is 2 months of bedaquiline (B or BDQ), moxifloxacin (M), pyrazinamide (Z), (BMZ) plus rifabutin (Rb) (BMZRB) followed by 2 months of bedaquiline (B or BDQ), moxifloxacin (M) and Rifabutin (Rb) (2 BMZRb/2 BMRb, … |
JOSEPH BURZYNSKI; | 2023-11-21 |
| 70 | A Multicenter, Randomized, Parallel-group, Double-blind,Two-arm Phase III Study to Evaluate The Safety and Efficacy of Anifrolumab Compared With Placebo in Male and Female Participants 18 to 70 Years of Age Inclusive With Systemic Sclerosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and safety of treatment with subcutaneous anifrolumab versus placebo in adult participants with systemic sclerosis. The target population for this study includes patients who meet the 2013 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification for systemic sclerosis, either limited or diffuse cutaneous subsets, with a disease duration of less than 6 years from first non-Raynaud’s phenomenon symptom. |
ASTRAZENECA | 2023-11-08 |
| 71 | A Randomized, Open, Multicenter, Phase IIa Clinical Study on The Early Bactericidal Activity, Safety, Tolerance and Pharmacokinetics of JDB0131 Benzenesulfonate Tablets in Drug Sensitive Pulmonary Tuberculosis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, open, drug controlled design of experiments was used to evaluate the early bactericidal activity, safety, tolerance and pharmacokinetic characteristics of JDB0131 benzenesulfonate tablet taken orally by drug sensitive pulmonary tuberculosis patients. Five groups are proposed to be set up in this test (JDB0131 benzenesulfonate 100mg BID, JDB0131 benzenesulfonate 200mg QD, JDB0131 benzenesulfonate 200mg BID, anti tuberculosis drug fixed dose composite dosage QD is determined according to the weight of the study participants, and delamanid 100mg BID) |
CHU NAIHUI; | 2023-10-31 |
| 72 | The Effect of Platelet Rich Plasma in The Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asherman syndrome, which occurs after trauma to the basalis layer of the endometrium. It seems that the role of postoperative platelet rich plasma（PRP）therapy in the prevention of recurrence of IUA is still controversial. To investigate if PRP therapy can prevent adhesion reformation after adhesiolysis. After the completion of hysteroscopic adhesiolysis, recruited patients will be randomized to one of the two treatment groups by computer-generated numbers: having PRP after hysteroscopic adhesiolysis; and the control group without PRP treatment. A second-look hysteroscopy and ultrasound assessment of the endometrium will be carried out 4 weeks after the surgery, … |
YANG LING LING; | 2023-10-10 |
| 73 | Pattern and Outcome of Respiratory Diseases in Patients Admitted in The Chest Department at Assiut University Hospital PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine the pattern and outcome of respiratory diseases in adults patients admitted to the Department of Chest Diseases at Assiut University Hospital. |
FATMA HAMDAN ZAKI ADEEL; | 2023-10-01 |
| 74 | Closing The Gap in Public Perception and Policy for SARS-CoV-2 Whole Genome Sequencing and Genomics for All PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Gap in understanding undermines government and public support for SC2-WGS, and other wide-scale genomic sequencing (Gut microbiome, Genome Wide Sequencing for Prenatal Detection, Tuberculosis Metagenomic sequencing, Nutrigenetics and Cancer Next Generation Sequencing) as a routine part of the pandemic response, especially in low- and middle-income countries. However, such gaps can be closed with systematic efforts to define and measure specific misperceptions, and subsequently design and use targeted messages and promotional materials. We propose here in the following specific aims to first determine the entire set of beliefs and emotions regarding SC2-WGS and other genomic sequencing (Gut microbiome, … |
RINA AGUSTINA; | 2023-10-01 |
| 75 | A Retrospective Study on Disease Characteristics of Hospitalized Patients With Community-acquired Pneumonia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: At present, the epidemiological characteristics and the distribution of pathogens of community-acquired pneumonia in Shandong Province are not clear. In order to understand the characteristics of community-acquired pneumonia, the distribution of pathogens and the risk factors of complications in Shandong Province, it is necessary to carry out investigation and study, which will provide the basis and support for the future prospective cohort study of pulmonary infection. |
QIAN QI; | 2023-09-22 |
| 76 | Effectiveness of Context-adapted Alternative Feeding Regimen on Recovery of Children Aged 6-59 Months From Moderate Acute Malnutrition and Uncomplicated Severe Acute Malnutrition in Bangladesh. A Cluster Randomized Control Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In spite of the large burden of acute malnutrition in the country, the Community-based Management of Acute Malnutrition (CMAM) protocol approved in Bangladesh highly deviates from the WHO normative guidance, in that it does not support the use of any currently existing nutritional products for Moderate Acute Malnutrition (MAM) cases: it relies solely on nutrition counselling. On another hand, some non-governmental organizations (NGOs) are implementing programs making a standard use of specialized nutritional products, such as nutritional supplements like Wheat Soy Blend (WSB)++ to manage MAM cases, … |
MD MUNIRUL ISLAM; | 2023-09-20 |
| 77 | A Multicenter Randomized, Double-blind, Placebo-controlled Phase 2 Study to Evaluate Efficacy, Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK3858279 in Adult Participants With Chronic Diabetic Peripheral Neuropathic Pain (DPNP) /NEPTUNE-17 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter randomized, double-blind, placebo-controlled phase 2 study to evaluate efficacy, safety, tolerability, pharmacokinetics, and target engagement of GSK3858279 in adult participants with chronic Diabetic Peripheral Neuropathic Pain (DPNP). The primary objective of the study is to assess the efficacy of GSK3858279 in participants with DPNP who have been unable to sufficiently manage their pain. |
GLAXOSMITHKLINE | 2023-09-20 |
| 78 | A Multicentre Randomized, Double-blind, Placebo Controlled, Dose-finding, Phase 2 Study (MARS-17) of GSK3858279 in Adult Participants With Moderate to Severe Pain Due to Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is dose-finding study of GSK3858279 in participants with moderate to severe knee osteoarthritis pain. The purpose of this study is to investigate and provide the data necessary to select the optimal effective and safe dose(s) of GSK3858279. |
GLAXOSMITHKLINE | 2023-09-13 |
| 79 | Effect of Endurance Training On Functional Capacity and Quality of Life in Patients With Post-TB Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effects of endurance training on functional capacity and QOL(Quality of life) in patients with post-TB (tuberculosis) lung disease. Post-tuberculosis lung disease is a major health concern nowadays. There is limited evidence in the literature regarding the rehabilitation of patients with cured tuberculosis which leads to post-TB complications. |
MEHWISH WASEEM; | 2023-09-11 |
| 80 | Impact Evaluation of Use of MATCH AI Predictive Modelling for Identification of Hotspots for TB Active Case Finding in Pakistan: A Pragmatic Stepped Wedge Cluster Randomized Trial PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this pragmatic, stepped wedge cluster-randomized trial is to measure the comparative yield (number of incident TB cases diagnosed during active case-finding camps) using a site selection approach based on predictions generated via an artificial intelligence software called MATCH-AI (intervention group) versus the conventional approach of camp site selection using field-staff knowledge and experience (control group). The trial will help inform whether a targeted approach towards screening for TB using artificial-intelligence can improve yields of TB cases detected through community-based active case-finding. |
FARAN EMMANUEL; | 2023-09-01 |
| 81 | Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are: * the proportion of MTB infection among school contacts of ATB patients * risk factors related to tuberculosis (TB) infection * health economic evaluation of screening strategy |
WEN-HONG ZHANG; | 2023-09-01 |
| 82 | TB YOUTH – TB SYstemic Management Using One-month, Ultra-short TPT Regimen for ScHool Contacts PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, multi-center, open-label, cluster randomized controlled clinical trial conducted in school settings to estimate the non-inferiority effect of 1H3P3 compared with 3HR. |
WEN-HONG ZHANG; | 2023-09-01 |
| 83 | Etiology Analysis of Chronic Cough After COVID-19 Infection and Research on The Efficacy of ICS or ICS/LABA PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study collected 600 patients, evaluated whether patients had airway hyperreactivity, airway inflammation, specific types and allergic reactions, comprehensively analyzed and classified the causes of chronic cough in patients, and evaluated and compared the improvement of cough symptoms and quality of life after ICS or ICS/LABA treatment. |
JUAN JIANG; | 2023-09-01 |
| 84 | Characteristics and Outcomes of TB and HIV Co-infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: People Living with HIV (PLHIV) are prone to several opportunistic infections depending on the degree of immunosuppression as well as infections prevalent in their geographic area/country. These include a wide variety of mycobacterial diseases, fungal infections, bacterial pneumonias, pneumocystis jirovecii pneumonia, cryptococcal infections, … |
WALEED GAMAL ELDDIN KHALEEL; | 2023-09-01 |
| 85 | Impact of Vitamin D Supplementation on Fetomaternal Outcomes in Pregnant Females With Latent Tuberculosis Infection: A Randomized Controlled Trial in Lahore-Punjab PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to see the effect of vitamin D supplementation on fetomaternal outcomes in pregnant females with Latent Tuberculosis infection The main question[s] it aims to answer are: If Vitamin D supplementation has any impact on maternal outcomes. If Vitamin D supplementation has any impact on fetal outcomes. |
USMAN JAVED IQBAL; | 2023-09-01 |
| 86 | Laparoscopic Tubal Disconnection Versus Laparoscopic Salpingectomy in Infertile Patients Scheduled for IVF/ICSI. Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tubal factor infertility is known to be one of the most common indications for IVF treatment. Patients with hydrosalpinges have been identified to have poor pregnancy outcomes such as lower implantation and pregnancy rates & higher rates of spontaneous abortion and ectopic pregnancies. Surgical intervention can be recommended for patients with hydrosalpinx prior to IVF/ICSI. This study will be done at Ain Shams University Maternity Hospital, to compare laparoscopic salpingectomy & laparoscopic tubal disconnection as two surgical modalities of treatment of unilateral or bilateral hydrosalpinges in women older than 30 years and scheduled for IVF/ICSI, regarding implantation rates, … |
AHMED MOHAMMED ELMARAGHY; | 2023-08-30 |
| 87 | Clinical Evaluation of The NanoDetect-TB Mycobacterium Tuberculosis Detection Kit for The Diagnosis of Tuberculosis Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is investigate the accuracy of the NanoDetect-TB kit in diagnosing tuberculosis (TB) using frozen serum and plasma samples collected from individuals suspected to have TB disease. The main question[s] it aims to answer are: – How does this investigational device compare to the gold standard for TB diagnosis of sputum culture? – How does it compare to Acid-Fast Bacteria (AFB) smear microscopy and FDA-approved NAAT TB diagnostic assays? Participants will be asked to have blood drawn and provide demographic and medical data for this study in a single visit. |
NANOPIN TECHNOLOGIES | 2023-08-01 |
| 88 | A Phase IIb, Open-Label, Randomized Controlled Dose Ranging Multi-Center Trial to Evaluate The Safety, Tolerability, Pharmacokinetics and Exposure-Response Relationship of Different Doses of BTZ-043 in Combination With Bedaquiline and Delamanid in Adult Subjects With Newly Diagnosed, Uncomplicated, Drug-sensitive Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2B, open label study, that will compare the safety and efficacy of three experimental regimens consisting of bedaquiline and delamanid in combination with different doses of BTZ-043, a novel antibiotic, in adult participants with newly diagnosed, drug-sensitive pulmonary tuberculosis. Participants will be assigned to receive either one of the three BTZ-043-containing regimens or a comparator regimen consisting of bedaquiline, delamanid and moxifloxacin. The objective is to find the optimal dose of BTZ-043 with the highest efficacy and safety to be used in subsequent studies. |
MICHAEL HOELSCHER; | 2023-08-01 |
| 89 | The Effect of Breathing Exercises on Pain, Anxiety, Dyspnea, and Insomnia in Patients Undergoing Lung Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Surgical treatment is performed with the aim of reducing, halting the progression of, or treating certain pathological conditions in the human body by removing some tissue or organs from the body. Wedge resection is considered an effective method for the treatment of lung cancer. The wedge resection method is utilized in both malignant and non-malignant pulmonary pathologies (such as bronchiectasis, aspergilloma, non-tuberculous mycobacteria, tuberculosis, fungal infections, inflammatory pseudotumors, hydatid cyst, and benign masses). Following surgical procedures such as Video-Assisted Thorascopic Surgery (VATS) and wedge resection, side effects and complications such as atelectasis, pneumonia, acute respiratory distress syndrome, prolonged air leakage, … |
FATMA GÜNDOĞDU; | 2023-08-01 |
| 90 | A Phase Ib/IIa Two-part, Randomized, Placebo-controlled, Observer-blind, Dose-finding Evaluation Trial to Describe The Safety, Reactogenicity, and Immunogenicity of Two Investigational Vaccines Against Tuberculosis in BCG Vaccinated, HIV-negative Subjects and People Living With HIV PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a two-part randomized, placebo-controlled, observer-blind, safety and dose-finding Phase Ib/IIa study. This study will evaluate up to four dose levels of the BNT164 investigational vaccines (BNT164a1 and BNT164b1) to select a safe and tolerable dose in a three-dose schedule. This study includes: Part A (Phase Ib) and Part B (Phase IIa). |
BIONTECH SE | 2023-07-31 |
| 91 | Using Short Message Service Reminders, Phone Calls and Mobile Money Incentives to Enhance Linkage to Care of Presumptive Tuberculosis Patients in Uganda: A Randomised Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The major challenge in meeting the WHO’s End TB Strategy- reducing tuberculosis (TB) deaths by 90% and incidence by 80% is the cascading patient loss-to-follow-up (LTFU) along the continuum of TB care. A systematic review found high levels of pre-treatment LTFU-ranging from 4 to 38%, and was higher in sub-Saharan Africa (18%) compared to Asia (13%). Consequences of pre-diagnosis and pre-treatment LTFU are; untreated TB patients are infectious and can transmit TB to others and not starting TB treatment at all, causes high morbidity and mortality. Therefore, … |
ESTHER BUREGYEYA; | 2023-07-24 |
| 92 | Phase 2 Clinical Trial of Randomized, Blinded, Positive-controlled to Explore The Skin Test Dosage of EEC in People Aged 18 to 65 Years Old and The Safety and Preliminary Efficacy in People Aged 3 to 75 Years Old PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, blind, positive-controlled study to explore the skin test dosage of recombinant mycobacterium tuberculosis fusion protein ( EEC) in the population aged 18 to 65 years old , and to further evaluate the safety and preliminary efficacy of EEC in the population aged 3 to 75 years old. In the first stage,180 healthy subjects, 140 tuberculosis（TB）subjects and 40 non-TB subjects with lung diseases aged 18 to 65 years old are divided into different groups through a randomized, blind methods. Every group carry out a low-dose (2.5μg/ml) or high-dose (5μg/ml) study, … |
NAIHUI CHU; | 2023-07-18 |
| 93 | Analysis of Volatile Organic Compounds in Expired Air in Healthy Volunteers: Comparison of Three Mass Spectrometry Techniques for The Characterization of Volatolome in Clinical Studies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A major obstacle in precision medicine is the unavailability of biomarkers that are easy to access, non-invasive, measurable with high-performance techniques, fast, easy to use, reproducible, inexpensive and easily deployable on a large scale. The analysis of exhaled air (volatolomics) is an omics approach devoted to the analysis of volatile organic compounds (VOCs) eliminated by the pulmonary route with real-time detection, at the patient’s bedside. The reference technology for the analysis of VOCs is mass spectrometry (MS). Several types of mass spectrometers can be used, and, in the absence of a consensual and standardized method, … |
HOPITAL FOCH | 2023-07-08 |
| 94 | Isoniazid Prophylaxis Based on Risk Factors of Tuberculosis in Living Kidney Transplantation Recipients: A Retrospective Cohort Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is a major and severe opportunistic infection among solid organ transplant recipients. Chemoprophylaxis is advised for those with latent tuberculosis infection (LTBI). However, the effectiveness of an isoniazid (INH) prophylactic approach based on TB risk factors, without relying on tuberculin skin test (TST) or interferon-gamma release assay (IGRA), remains uncertain. Therefore, the investigators conducted this retrospective study to evaluate the safety and efficacy of a 6-month INH prophylaxis regimen guided by TB risk factors in kidney transplant recipients. |
TAO LIN; | 2023-06-01 |
| 95 | Construction and Validation of A Computer-aided (CADx）System in Real-time Characterization of Colorectal Ulcerative Diseases: A Multicenter, Retrospective Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to construct and validate a Computer-aided (CADx）System in Real-time Characterization of Colorectal Ulcrerative Diseases. The main question it aims to answer are to demonstrate whether the newly developed CADx system has a high-level diagnostic accuracy in predicting characterization of colorectal ulcerative diseases. It is a multi-center, retrospective study. The study retrospectively collected colonoscopy images and videos of colorectal ulcers (including colorectal cancer, Crohn’s disease, Ulcerative colitis, Intestinal tuberculosis and ischemic enteritis). A training cohort will be developed from majority of the included cases, … |
NANFANG HOSPITAL SOUTHERN MEDICAL UNIVERSITY | 2023-06-01 |
| 96 | Delivering An Innovative Multi-disease Screening Tool to High-risk Migrant Populations PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Migrants’ overall health status may be improved by increasing the detection of certain infectious diseases and other conditions for which effective care is available. This can be achieved through a systematic screening of these conditions using innovative and digital solutions implemented in routine health care. This study aims to evaluate the implementation of a screening programme for migrants at primary care level in two different settings of Spain (Catalonia and Andalusia) using an innovative digital and user-friendly software tool (ISMiHealth). In Catalonia, … |
ANA REQUENA MÉNDEZ; | 2023-06-01 |
| 97 | Evaluation of Clinical Practice Guidelines and Educational Decision-support Tools on Medical Trainees’ Confidence With Latent Tuberculosis (LTBI) Testing and Treatment: A Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Latent Tuberculosis infection (LTBI) guidelines can be complex. LTBI-ASSIST is a web-based interactive tool to navigate US LTBI clinical practice guidelines in a patient-centered format that may guide clinical decision making around Latent TB care. The research goal is to determine the difference in reported confidence among trainees that are not experts in LTBI care. The investigators further aim to assess if access to the LTBI-ASSIST tool improves clinical decision making in a series of simulated case scenarios containing guideline-derived, multiple choice items, as well as assess the efficiency in navigating the scenarios – … |
MAUNANK SHAH; | 2023-06-01 |
| 98 | Effect of Breathing Exercise on Fatigue in Patients With Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis is a chronic, necrotic infectious disease with very different clinical appearances, caused by a group of mycobacteria defined as M. tuberculosis complex. Although there is a vaccine and can be treated with combined medications, this health problem remains important all over the world, especially in poor countries. Generally, respiratory symptoms that occur in a person with tuberculosis include cough, phlegm, hemoptysis, chest pain, and shortness of breath for more than three weeks. If there is a partial obstruction in the bronchi due to the compression of enlarged lymph nodes, … |
SEMA AYTAÇ; | 2023-06-01 |
| 99 | Biodistribution and Pharmacokinetics of Pretomanid in Tuberculosis Patients Using 18F-Pretomanid PET PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study that will examine the pretomanid pharmacokinetics (PK) in tuberculosis (TB) patients. Dynamic 18F-pretomanid PET/CT will be performed after intravenous injection of 18F-pretomanid to determine multi-compartment, noninvasive determination of pretomanid PK in TB patients. |
SANJAY K JAIN; | 2023-05-22 |
| 100 | Exhaled Breath Aerosol for The Etiological Diagnosis of Respiratory Tract Infections: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pilot study for the evaluation of the feasibility of pathogen detection in exhaled breath aerosols (XBAs) samples using the AveloCollect device. The aim of the study is to evaluate the feasibility of XBA collection and molecular detection of respiratory pathogens using the AveloCollect BlowTube device (index test) in subjects with a clinical presentation consistent with a respiratory infectious disease, compared to the same molecular assays performed on nasopharyngeal secretions (using commercially available swabs) and sputum (comparator tests). |
DANIELA MARIA CIRILLO; | 2023-05-15 |
| 101 | Randomized, Double-blind, Placebo-controlled Phase 1 Trial of ТВ/Flu-05Е Intranasal Vector Vaccine for The Prevention of Tuberculosis Infection in BCG-vaccinated Volunteers Aged 18-50 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate safety, reactogenicity and immunogenicity of the TB/Flu-05E single-dose intranasal vaccine for the prevention of Tuberculosis infection in BCG-vaccinated Volunteers aged 18-50 years. |
TATYANA ZUBKOVA; | 2023-05-10 |
| 102 | Evaluation of Tuberculosis Treatment Outcomes Before, During and After COVID-19 in A Dedicated Outpatient Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is an infectious disease caused by Mycobacterium species grouped in the Mycobacterium tuberculosis complex. TB remains a major global health problem, despite the fact that there are drugs that can eradicate the infection. The study aims to describe the clinical, microbiological, therapeutic and prognostic characteristics of TB patients afferent to the SC Infectious Diseases of A.O. SS Antonio e Biagio e Cesare Arrigo of Alexandria during 2019-2022 and, secondarily, … |
AZIENDA OSPEDALIERA SS ANTONIO E BIAGIO E CESARE ARRIGO DI ALESSANDRIA | 2023-05-08 |
| 103 | A Feasibility Study of Controlled Human Infection With Intradermal Bacillus Calmette-Guérin Injection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is a disease that usually causes an infection in the lungs. The only vaccine to prevent TB is called BCG (Bacillus Calmette-Guérin). BCG contains a live germ similar to Mycobacterium tuberculosis, the germ that causes TB. BCG does not work very well, … |
BEN MORTON; | 2023-05-02 |
| 104 | Frequency of Tuberculosis in Psoriasis Patients Using Anti-TNF Therapy During 15 Years of Follow-up PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of this study is evaluation of patients receiving TNF inhibitor therapy in terms of tuberculosis at the end of 15 years in a single center. |
BEZMIALEM VAKIF UNIVERSITY | 2023-05-01 |
| 105 | Active Close Contact Investigation of Tuberculosis Through Computer-aided Detection and Stool Xpert MTB/RIF Among People Living in Oromia Region, Ethiopia: A Prospective, Cross-sectional Study (CADOOL Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis is the 13th cause of death from all causes, infecting roughly the 25% of the world population, and Ethiopia is listed among the 30 high-burden countries both for TB and for HIV/TB. In recent years, the immediate consequence of the COVID-19 pandemic was a large fall in the number of newly reported TB cases indicators that represent a relevant drawback in the pursue of the 2025 End TB Milestones. For active case investigation of TB close contacts, WHO recently recommended the use of Computer- aided detection (CAD), … |
WORKU NIGUSSA; | 2023-05-01 |
| 106 | Evaluation of The Early Bactericidal Activity of Tedizolid and Linezolide Against Mycobacterium Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this work is to measure the early bactericidal activity of tedizolid, to compare it with the bactericidal activity of linezolid (reference molecule for the treatment of multidrug-resistant tuberculosis) and with that of standard quadruple therapy (reference treatment of drug susceptible tuberculosis). |
NICOLAS VEZIRIS; | 2023-04-20 |
| 107 | Immunogenicity of COVID-19 Vaccines Against Coronavirus Disease (COVID-19) Among Tuberculosis (TB) Patients in Thailand-Myanmar Border PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a non-randomized observation and comparison of immune response between bacteriologically confirmed TB patients under treatment cohort who received COVID-19 vaccine (n=54) vs healthy individuals (n=54). Each participant will receive single or double doses of one of COVID-19 vaccines (Pfizer-BioNTech COVID-19 vaccine, … |
FRANÇOIS NOSTEN; | 2023-04-15 |
| 108 | A Multiple Arm, Multiple Stage (MAMS), Phase 2B/C, Open Label, Randomized, Controlled Platform Trial to Evaluate Experimental Arms Including An Increased Dose of Rifampicin, An Optimized Dose of Pyrazinamide, Moxifloxacin and Sutezolid, in Adult Subjects With Newly Diagnosed, Smear-positive Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2B/C, open label platform study that will compare the efficacy, safety of 3 experimental regimens with a standard control regimen in participants with newly diagnosed, drug sensitive pulmonary tuberculosis. In stage 1, participants will be randomly allocated to the control or one of the 2 rifampicin-containing experimental regimens in the ratio 1:1:1. In stage 2, the experimental arm 4 containing sutezolid will be added. Participants will be allocated to control or one of the three experimental regimens in the ratio 1:1:1:1. Towards the end of stage 2, … |
MICHAEL HOELSCHER; | 2023-04-14 |
| 109 | Descriptive Epidemiological Study of Hospitalized Children for Pulmonary Tuberculosis at Strasbourg University Hospitals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary tuberculosis is the most common form of tuberculosis in children; According to the WHO, tuberculosis pulmonary tuberculosis in children represents approximately 80% of all cases of tuberculosis in children. In 2020, there were approximately 1.0 million new cases of pulmonary tuberculosis among children worldwide. In France, childhood tuberculosis remains a rare disease; the most recent data show a rate of 3.3 cases per 100,000 inhabitants among children under 15 years old in 2019. Pulmonary tuberculosis in children can lead to complications such as bronchiectasis and pneumothorax. Children living in homes where an adult has a active tuberculosis, … |
LAURENCE WEISS; | 2023-04-04 |
| 110 | A Randomized Trial Comparing Treatment Completion of Daily Rifapentine & Isoniazid for One Month (1HP) To Weekly Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in HIV-negative Household Contacts of Recently Diagnosed Tuberculosis Patients, The One To Three Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A multicenter, randomized, stratified, open-label, phase IV trial among HIV-positive persons (PLHIV) on antiretroviral therapy (ART), or HIV-negative household contacts of patients with rifampicin-sensitive pulmonary tuberculosis (TB), who do not have evidence of active TB. |
THE AURUM INSTITUTE NPC | 2023-04-01 |
| 111 | A Prospective Observational Study on The Role of Transthoracic Ultrasound in Differentiating Tuberculous From Malignant Pleural Effusion PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Endpoint – To assess the prevalence and diagnostic performance of pre-determined echographic features in predicting the diagnosis of TBE from MPE. – To determine the clinical, pleural fluid and echographic parameters that were different among TBE and MPE and to establish a clinical prediction model for TBE. Secondary Endpoint – To assess the correlation between pleural fluid parameters with ultrasound and medical thoracoscopic finding. – To assess the optimal Pf ADA cut-off value to differentiate TBE from MPE in our region. |
KHO SZE SHYANG; | 2023-04-01 |
| 112 | Point-of-care Pharmacogenomic Testing to Optimize Isoniazid Dosing for Tuberculosis Prevention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial is designed to determine whether modifying the dose of isoniazid for individuals according to their n-acetyltransferase 2 (NAT2) genotype could increase the probability of achieving equivalence of area-under-the-curve. |
JASON ANDREWS; | 2023-03-23 |
| 113 | NRX-101 for Treatment-Resistant Bipolar Depression in Patients At Risk for Self-Harm Related Papers Related Patents Related Grants Related Experts View Highlight: There is no currently-approved pharmacotherapy for patients with Treatment-Resistant Bipolar Depression and Suicidal Ideation or behavior. The purpose of this Expanded Access Treatment Protocol is to make NRX-101 available to patients who have depression and suicidal ideation despite treatment with currently approved medication and to gather information on safety and efficacy in a real-world data environment. Participants will be treated by their own practicing psychiatrist and will agree to periodic psychometric evaluations to assess depression, suicidal ideation, and side effects. |
JONATHAN C JAVITT; | 2023-03-08 |
| 114 | A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, multicenter, observational study (mEX-TB study) of patients with extrapulmonary tuberculosis (EPTB). Adult patients newly diagnosed with EPTB will prospectively be enrolled into the study. Clinical data will be collected using standardized questionnaires over the whole treatment period for each individual. Additionally, body fluids (blood, urine) will be collected and stored in a central biobank. Biomarkers in EPTB patients will be analyzed during the course of therapy and correlated with clinical data. In addition, a healthy control group will be added, … |
ISABELLE SUAREZ; | 2023-03-06 |
| 115 | Prospective Analysis of Pharmacokinetic Infliximab Data in Pediatric CD Patients (ProRAPID) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Crohn’s disease (CD) is a chronic, debilitating inflammatory bowel disease (IBD) which is diagnosed during childhood in up to one in ten patients. The use of anti-tumor necrosis factor (TNF)-α agents has significantly ameliorated CD management. Infliximab (IFX) is the first anti-TNF-α agent registered for pediatric CD. The current dosing recommendation of IFX is extrapolated from adult studies, and it is a weight-based dose (5 mg/kg) delivered during induction (infusion at weeks 0, 2, and 6) and maintenance (every 8 weeks). However, pediatric patients have a 25-40% lower drug exposure compared to adults, … |
LISSY DE RIDDER; | 2023-03-01 |
| 116 | Demonstrating Multipronged and Optimized Novel Strategies to Reinforce Actions Targeted At Eliminating Tuberculosis (DeMONSTRATE-TB): A Sequential Exploratory Mixed Method Study in Ethiopia PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: Ending the TB epidemic by 2035 in Ethiopia would be possible if TB notification declines by an annual factor of at least 15% from the current notification rate of 132 per 100,000 population. This requires highly effective strategies to reduce TB transmission and maximize TB prevention among populations at risk of developing TB, … |
MANAGEMENT SCIENCES FOR HEALTH | 2023-02-27 |
| 117 | ANRS 12404 TIMPANI: Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis MeNIngitis: A Phase II, Multicenter, Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized phase II clinical trial which aims to assess the impact on 3-month mortality and safety of adding adalimumab to standard treatment (anti-tuberculosis drugs and corticosteroids) in HIV patients with tuberculosis meningitis in 3 countries (Brazil, Mozambique, and Zambia). |
NATHALIE DE CASTRO; | 2023-02-15 |
| 118 | Impact of The Second Vs. Conventional Examination of The Proximal Colon on Adenoma Miss Rate, A Prospective Randomized Tandem Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: .Studies have demonstrated that the second examination of the proximal colon can significantly increase the proximal ADR.This study aimed to determine the impact of second examination of the proximal colon on AMR compared to conventional examination.Consecutive patients aged 40-75years undergoing colonoscopy for screening.Tandem withdrawal was used in the proximal colon.Patients were randomly assigned to either the second examination(SE) or the conventional examination(CE) group.The primary outcome measure was proximal AMR,defined as the number of proximal adenomas detected in the second pass（CE group）or the third pass（SE group）divided by the total number of proximal adenomas detected during the tandem colonoscopy. |
THIRD PEOPLE’S HOSPITAL OF JINGDEZHEN CITY | 2023-02-15 |
| 119 | Efficacy and Safety of Hydroxychloroquine in Colchicine-RESistant Glucocorticoid-DependenT IdiOpathic REcurrent Pericarditis: A Randomized Clinical Trial (The RESTORE Randomized Clinical Trial) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Among patients with colchicine-resistant glucocorticoid-dependent idiopathic RP (idiopathic recurrent pericarditis during at least a second recurrence, having met the 2015 European Society of Cardiology criteria for pericarditis at least once), HCQ 400mg daily is associated with a reduce the risk of recurrence. The above hypothesis will be tested with a randomized, prospective, parallel, open label clinical trial. The expected study duration is approximately 12 months from the time the first subject is enrolled (planned for February 2023) to the time of study’s termination date (December 2024). The researchers will obtain approval by the institutional review board (IRB). |
KONSTANTINOS TSIOUFIS; | 2023-02-01 |
| 120 | Microbiological Profile of Ventilator Associated Pneumonia in Respiratory Intensive Care Unit of Assiut University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Identification of the microbial profile of Ventilator associated pneumonia causing microorganisms among Respiratory ICU patients . |
MANAR ABDELHAMEED HASSAN ALI; | 2023-02-01 |
| 121 | Safety, Tolerability and Drug-drug Interactions of Short-course Treatment of Latent Tuberculosis Infection With High-dose Once-weekly Rifapentine and Isoniazid (3HP) Among Infants, Children and Adolescents Living With HIV Taking Dolutegravir-based Antiretroviral Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Single-arm, multi-center, Phase I/II clinical trial, in two groups. Individuals with HIV infection taking Efavirenz (EFV), nevirapine (NVP) or lopinavir/ritonavir (LPV/r) and two nucleoside reverse transcriptase inhibitors (NRTI) who have undetectable HIV viral load (VL) (< 50 copies/mL) and an indication for tuberculosis (TB) preventive treatment (TPT), will be switched to dolutegravir (DTG) with tenofovir/emtricitabine (TDF/FTC), tenofovir/lamivudine (TDF/3TC), ... |
NICOLE SALAZAR-AUSTIN; | 2023-01-30 |
| 122 | Integrating Addiction and Infectious Diseases Services Into Primary Care in Rural Settings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate an intervention strategy in introducing screen/evaluate/treat (SET) procedures for HIV/ hepatitis C/ and Opioid Use Disorder in Primary Care Clinics in West Virginia. The main questions it aims to answer are: * What are the barriers and facilitators to integrating evidence based practices for screening and treatment of HIV, hepatitis C, and Opioid Use Disorder into primary care clinics in West Virginia? * To assess the extent to which our SET processes are achieved through enhanced EHR tools, … |
FREDERICK L ALTICE; | 2023-01-24 |
| 123 | Phase I Clinical Trial to Evaluate The Safety and Tolerability of Recombinant Mycobacterium Tuberculosis Fusion Protein (EEC) in Healthy Adults Aged 18-65 and Patients With Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is to enroll 60 participants aged 18-65 years old, including 30 healthy subjects and 30 tuberculosis patients. Low-dose (2.5 μg/ml), medium-dose (5 μg/ml), and high-dose (10 μg/ml) studies will be conducted separately for healthy subjects and pulmonary tuberculosis patients, with 20 participants in each dosage group. Within 28 days after the skin test of the test drug, observations were made of reactions at the skin test site, reactions at non-skin test sites, concomitant medication, and any other physical discomfort (skin test site-specific reactions were recorded separately). |
CHENGDU COENBIOTECH | 2023-01-17 |
| 124 | Relevance of Isoniazid Dosage in Adults Treated for Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis is the third leading infectious killer. In 2021, an estimated 10,6 million people fell ill with tuberculosis worldwide. Drug resistance emerges with the increase of antibiotherapy use. Among the four antimicrobial drugs used for tuberculosis, isoniazid is a first line treatment. It has a bactericidal activity against the tuberculosis complex. Nevertheless, the hepatic metabolism of isoniazid shows variation between individuals. There is a real risk of hepatotoxicity and neurotoxicity induced by isoniazid. The peak measurement (Cmax) of serum isoniazid is recommended to adjust the treatment and to allow recovery. Moreover, … |
CENTRE HOSPITALIER UNIVERSITAIRE AMIENS | 2023-01-04 |
| 125 | Diagnosis Test of Real-time Polymerase Chain Reaction (RT-PCR) for Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: BACKGROUND: Pulmonary tuberculosis remains the leading cause of morbidity and mortality in Thailand. The microbiological detection of TB is important because of early and correct diagnosis, drug resistance testing and ensures that the effective treatment can be achieved and in a timely manner. Mycobacterial culture is the gold standard diagnostic test. Currently, a real-time polymerase chain reaction (RT-PCR) assay, such as Allplex™ MTB/MDRe Detection, Seegene is commonly used. OBJECTIVE: To evaluate the diagnosis value of the real-time multiplex PCR by using Allplex™ MTB/MDRe Detection kit to detect MTB from sputum specimens with a gold standard TB culture. |
KRIENGSAK VACHARANUKULKIETI; | 2023-01-01 |
| 126 | Early Bactericidal Activity of Cephalexin and Amoxicillin-clavulanate for Susceptible Tuberculosis – BLAST 1 Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to study the early bactericidal activity in adult patients with smear-positive pulmonary tuberculosis. The main question it aims to answer are if cephalexin, in combination with amoxicillin-clavulanate, … |
JAN-WILLEM ALFFENAAR; | 2023-01-01 |
| 127 | Pharmacokinetics and Pharmacodynamics of Multidrug-regimens for Mycobacterium Abscessus Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigating the PK and PD indices in patients with M. abscessus complex-PD who will be treated with a currently recommended regimen, minimum inhibitory concentrations of organism, and their relation with clinical outcomes |
JAE-JOON YIM; | 2023-01-01 |
| 128 | Safety and Efficacy of Adalimumab Therapy for Treatment of Behcet’s Disease-related Uveitis in Sohag University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the goal of this prospective cohort study is to asses the Safety and efficacy of Adalimumab therapy for treatment of Behcet’s disease-related uveitis in adult patients at sohag university hospital. Patients will receive adalimumab (40 IU), subcutaneous injection every two weeks for 6 months either as a primary treatment or if refractory to corticosteroids and at least one conventional synthetic immunosuppressive drug. |
MERVAT ZIDAN MAHMOUD; | 2022-12-15 |
| 129 | A Phase 2 Trial to Evaluate The EBA, Safety and Tolerability of Ethionamide Alone and in Combination With BVL-GSK098 Administered Orally to Adults With Newly Diagnosed, Rifampicin- and Isoniazid-Susceptible Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the 7-day early bactericidal activity (EBA), pharmacokinetics (PK), safety and tolerability of ethionamide (Eto) with or without BVL-GSK098 in participants with rifampicin- and isoniazid-susceptible pulmonary TB. |
REINARD MCPHERSON; | 2022-12-06 |
| 130 | Implementation of A New Strategic TB Case-Finding, Treatment and Prevention Public Health Pack in Thailand PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The project aimed to test a strategy for the early detection and prevention of tuberculosis in household contacts of tuberculosis patients in order to reduce the morbidity, mortality and transmission of this disease in Thailand. This strategy will be evaluated in comparison with the current programmatic approach through a pragmatic trial with cluster randomization (cluster randomized controlled trial) which will be conducted over the next 3 years. This project is carried out in collaboration with the Tuberculosis Division of the Ministry of Public Health of Thailand, … |
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT | 2022-12-01 |
| 131 | Eosinophil Associated Proteins and Microbiome Profiling in Adults With Eosinophilic Oesophagitis at A Single UK Tertiary Centre PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Eosinophilic oesophagitis (EoE) is an inflammatory condition of the oesophagus (food pipe) that can lead to difficulty swallowing and to food to getting stuck and has become increasingly common over the past 40 years. EoE is triggered by a protein in the diet but alterations to the types of bacteria (microbiome) in the oesophagus may also be involved. EoE is diagnosed with gastroscopy (a thin camera test via the mouth) where 6 tiny samples (biopsies) are taken. Treatment is either with removing food groups from the diet or medications including steroids (budesonide) or a proton pump inhibitor (PPI, … |
ST GEORGE’S UNIVERSITY OF LONDON | 2022-11-09 |
| 132 | The Effect of Steady State Aerobic Training on Insulin Sensitivity on Diabetic Patients During Tobacco Cessation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: – Prevalence of smoking in men and women ages 15 and over who currently smoke any tobacco product on a daily or non-daily basis Egypt smoking rate for 2018 was 21.40%, a 0.1% increase from 2016. – According to WHO reports, smoking is currently responsible for six million premature deaths every year, of which 600 000 individuals die from the effects of second-hand smoke. – … |
ALAA MOHAMED NAGUIB ASHRY; | 2022-11-09 |
| 133 | A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 2 Study to Evaluate Clinical Efficacy and Safety of Deucravacitinib (BMS-986165) in Participants With Alopecia Areata PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of deucravacitinib versus placebo at Week 24 and safety and tolerability of deucravacitinib versus placebo in adults with alopecia areata. |
BRISTOL MYERS SQUIBB | 2022-11-08 |
| 134 | Medical Thoracoscopy for Undiagnosed Transudative and Exudative Pleural Effusion PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Indonesia is one of country that contributes the most cases of tuberculosis worldwide. Tuberculosis is the most commonly etiology of exudative pleural effusion. There have been many studies about undiagnosed exudative pleural effusion, but there are not many studies about the use of medical thoracoscopy for diagnosing transudative and exudative pleural effusion, especially on biomarkers of C-Reactive Protein (CRP), D-dimer, Adenosine Deaminase (ADA), Antinuclear Antibody (ANA), C3 C4 complements, Cancer Antigen 125 (CA-125), Xpert Mycobacterium Tuberculosis (Xpert MTB), Lupus Erythematosus cell (LE cell), cytology (effusion and smear) and histopathology. Information gained from those biomarkers via thoracenthesis and medical troracoscopy, … |
GURMEET SINGH; | 2022-11-01 |
| 135 | Medical Thoracoscopy for Undiagnosed Transudative and Exudative Pleural Effusions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Indonesia is one of country that contributes the most cases of tuberculosis worldwide. Tuberculosis is the most commonly etiology of exudative pleural effusion. There have been many studies about undiagnosed exudative pleural effusions, but there are not many studies about the use of medical thoracoscopy for diagnosing transudative and exudative pleural effusion, especially on biomarkers of C-Reactive Protein (CRP), D-dimer, Adenosine Deaminase (ADA), Antinuclear Antibody (ANA), C3 C4 complements, Cancer Antigen 125 (CA-125), Xpert Mycobacterium Tuberculosis (Xpert MTB), Lupus Erythematosus cell (LE cell), cytology (effusion and smear) and histopathology. Information gained from those biomarkers via thoracocentesis and medical thoracoscopy, … |
GURMEET SINGH; | 2022-11-01 |
| 136 | The Effect of Art Therapy Applied to Mothers on Eating Behavior in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Art therapy; Art therapy is an integrative mental health service that enriches the lives of individuals, families, and communities through active art practices, the creative process, applied psychological theory, and human experience in a psychotherapeutic relationship. It is a therapeutic method used in the form of sessions to improve self-esteem and self-esteem. Art therapy used to develop emotional resilience, increase insight, develop social skills, reduce and resolve conflicts and distress seeks to both find an outlet for complex and intense emotions and It allows them to be verbally expressed at an intellectual level, … |
ELIF AKYİĞİT ALBAYRAK; | 2022-11-01 |
| 137 | Phase IIb Clinical Trial to Evaluate The Efficacy and Safety of The Administration of RUTI® Immunotherapy With The Standard Treatment in Patients With Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is proposed to evaluate the safety and efficacy of the RUTI vaccine in patients with pulmonary tuberculosis. Therapeutic vaccination of RUTI would stimulate the immune response not only against growing bacteria, but also against bacteria in a latent state that are less sensitive to antibiotic treatments. Therapeutic vaccination in patients with pulmonary tuberculosis could improve the speed of recovery of patients without inducing the appearance of drug resistance. |
ARCHIVEL FARMA S L | 2022-10-29 |
| 138 | Same-day Versus Rapid ART Initiation in HIV-positive Individuals Presenting With Symptoms of Tuberculosis: An Open-label Randomized Non-inferiority Trial in Lesotho and Blantyre District, Malawi PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: SaDAPT is a pragmatic, randomized, therapeutic-use trial comparing two approaches (ART first versus TB results first) for the timing of ART initiation in PLHIV with presumptive TB, but no signs of central nervous system (CNS) disease, in a routine primary and secondary care setting in southern Africa with regard to HIV viral suppression (VL \<400 copies/mL) 26 weeks after enrolment. |
NIKLAUS LABHARDT; | 2022-10-19 |
| 139 | Assessing The Effectiveness of Integration of Rapid Antigen Testing for SARS-CoV-2 in MNCH, HIV and TB Services in Cameroon and Kenya: A Pre- and Post- Implementation Evaluation (Effectiveness Study) PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: In many national Coronavirus Disease 2019 (COVID-19) response plans, including in Kenya and Cameroon, antigen detection tests are being used to improve access for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing. Targeting the populations most at risk for COVID-19 disease, including pregnant women, people living with HIV, and patients with tuberculosis (TB), and those who are the most vulnerable to transmission to other populations, can reduce the negative impact of the SARS-CoV-2 pandemic. Catalyzing COVID-19 Action (CCA) aims to strengthen detection by screening and diagnosing cases of SARS-CoV-2 in MNCH clinics, HIV clinics, … |
NILESH BHATT; | 2022-10-11 |
| 140 | Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis: A Phase III Randomized Control Trial (Doxy-TB) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is a global pandemic that despite successful treatment and bacterial eradication can cause chronic ill health, also known as pulmonary impairment after tuberculosis (PIAT). A recent Phase 2b double-blind randomised-controlled clinical trial shows that adjunctive doxycycline therapy along with standard pulmonary TB (PTB) treatment is safe, accelerates resolution of inflammation, … |
CATHERINE ONG; | 2022-10-03 |
| 141 | Phase 1b/2a Safety and Immunogenicity of The DNMT Inhibitor Azacitidine During Anti-Tuberculosis Therapy Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis has been shown to make immune genes inaccessible and slows immune response The purpose of this research is to see if if azacitidine is safe and can return the ability of the body to resist tuberculosis (TB), a contagious infection that attacks the lungs. Individuals with tuberculosis are being asked to participate. Some will receive a drug to restore a host immunity while others can choose to receive standard of care. All patients will continue to receive standard of care tuberculosis therapy regardless of whether they chose to participate in the study. This study is a Phase Ib/IIa single-institution, … |
ANDREW DINARDO; | 2022-10-01 |
| 142 | High-dose Intravenous Vitamin C As An Adjunctive Treatment for Sepsis in Rwanda: A Feasibility Trial Related Papers Related Patents Related Grants Related Experts View Highlight: This feasibility study serves to determine if it is possible to perform a powered randomized control trial of high-dose intravenous vitamin C (ascorbic acid) as an adjunctive medication in the management of sepsis and septic shock in Rwanda. Further data will be collected including Sequential Organ Failure Assessment (SOFA) score, Universal Vital Assessment (UVA) score, duration of vasopressors, … |
DENNIS A HOPKINSON; | 2022-10-01 |
| 143 | Hybrid Trial for Alcohol Reduction Among People With TB and HIV in India (HATHI) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The highest incidence of tuberculosis disease (TB) in the world is in India, accounting for 27% of all new cases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy alcohol use can worsen the health of people who have Tuberculosis (TB) and people who have both TB and HIV. Behavioral interventions that 1) target alcohol use and 2) are integrated into TB and HIV care may lead to better alcohol and treatment outcomes. The goal of this study is to test if a behavioral alcohol reduction intervention integrated into TB treatment can reduce alcohol use and improve TB and HIV health outcomes among people with unhealthy alcohol use. The aims of the HATHI study are: Aim 1: To test if a 4 session behavioral alcohol reduction intervention, called HATHI, integrated into TB and HIV Care can decrease unhealthy alcohol use among persons with TB and HIV. Aim 2: To test if the HATHI intervention, integrated into TB and HIV care can improve TB and HIV clinical outcomes; Aim 3: To evaluate barriers and facilitators to integrating HATHI intervention into TB and HIV care, and to determine the incremental costs of delivering HATHI intervention in TB and HIV clinical settings. Investigators hypothesize that HATHI intervention will reduce alcohol use among persons with TB and TB with HIV, and that its delivery in the TB and HIV setting will be acceptable and feasible to patients and providers. |
AMITA GUPTA; | 2022-09-22 |
| 144 | Genomic Study of Young-Onset Diabetes Mellitus PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes Mellitus (DM) has been a major contributor to health burden in Indonesia and currently its burden still continues to rise. This is a result of increasing DM prevalence in the country as well as high rates of chronic complications from DM. Findings in Indonesia show that there is a high proportion of young people with diabetes, and also a high risk of therapeutic failure and complications from DM occurring in the younger population. Young-onset DM has a wide clinical spectrum, including autoimmune DM, polygenic DM, … |
DICKY L TAHAPARY; | 2022-09-12 |
| 145 | Efficacy of N-acetylcysteine to Prevent Anti-tuberculosis Drug-induced Liver Injury: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the efficacy of NAC to prevent clinically significant anti-TB drugs induced liver injury (AT-DILI). |
WATCHARASAK CHOTIYAPUTTA; | 2022-09-09 |
| 146 | Tuberculosis Diagnostic Trial of CAD4TB Screening Alone Compared to CAD4TB Screening Combined With A CRP Triage Test, Both Followed By Confirmatory Xpert MTB/RIF Ultra in Communities of Lesotho and South Africa PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: According to WHO, about 40% of the incident TB cases in 2020 are either under-reported or under-diagnosed causing on one hand major health risks and on the other hand catastrophic financial consequences. In particular, indigent people in hard-to-reach communities with high TB/HIV burden are at high risk of missed or delayed diagnoses. Hence, active case finding for TB remains an integral part of tuberculosis control in high-risk groups, such as people living with HIV (PLHIV) or diabetes mellitus, people living in specific geographical locations associated with a high burden of TB and poor access to health care, miners, … |
KLAUS REITHER; | 2022-09-07 |
| 147 | A Pilot Study of 68Ga-FAPI-RGD PET/CT Imaging in The Lung Cancer Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Based on the high expression of specific receptors on the surface of diseased tissues and neovascularization, noninvasive targeted molecular imaging can be used to visualize lesions in vitro by combining specific ligands labeled with short half-life isotopes. Lung cancer tissues express fibroblast activating protein FAP, and also have high expression of integrin αVβ3 receptor on the surface of blood vessels. In this study, a novel dual-target imaging agent 68Ga-FAPI-RGD was used for PET/CT imaging of lung cancer. |
ZHAOHUI ZHU; | 2022-09-03 |
| 148 | A Multicenter, Randomized, Double-blind, Positive Control Study to Evaluate The Efficacy and Safety of Sudapyridine (WX-081) Tables in Patients With Rifampicin-resistant Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to demonstrate that the antibacterial activity of Sudapyridine (WX-081) is not inferior to Bedaquiline when added to a Background Regimen (BR) for treatment of rifampicin- resistant TB. Also, safety and clinical outcome will be evaluated. |
NAIHUI CHU; | 2022-09-02 |
| 149 | Evaluation of Molecular Point-of-care Xpert® Xpress SARS-CoV-2 Detection Implementation in Resource-limited Settings PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is envisaged to evaluate the diagnostic accuracy and effectiveness of POC viral load (VL) assay in improving the availability of SARS-CoV-2 detection for COVID-19 patient management in decentralized healthcare facilities of resource-constrained settings in Tanzania, DR Congo and Burkina Faso. |
DANIEL T MINJA; | 2022-09-01 |
| 150 | Latent Tuberculosis in Healthcare Workers – The Reality of A Portuguese Tertiary Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective, descriptive study to assess latent tuberculosis infection (LTBI) among healthcare worker (HCW) in a tertiary hospital in a low-risk area. |
CARINA ROLO SILVESTRE; | 2022-09-01 |
| 151 | Multicenter Prospective Evaluation of Rapid Viability Tests for Mycobacterium Tuberculosis to Improve The Follow-up of Tuberculosis Patients and Guide Isolation Measures PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the present study is to confirm in a multicentric study the utility of our viability test in large cohort of smear-positive pulmonary tuberculosis patients under treatment and to determine if the test could help physicians to discontinue isolation measures in hospital setting. |
BENJAMIN WYPLOSZ; | 2022-09-01 |
| 152 | A Spectrum of Hematological Disorders in Children Presented With Pancytopenia at Assiut University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the spectrum of pancytopenia with its frequency and etiology in children presenting to Assiut University Children Hospital during one year |
ZAKRIA YOUNES MOHAMMED ESSEMY; | 2022-09-01 |
| 153 | Molbio Truenat TB Platform Combined With The Truenat TB Assays for Detection of Tuberculosis and Rifampicin Resistance in Adults With Presumptive Pulmonary Tuberculosis at Primary-level Diagnostic Centres in Tanzania and Mozambique: A Pragmatic, Cluster-randomized Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A cluster randomized controlled trial to evaluate the effect of placing Truenat platform/TB assays at primary health care clinics combined with rapid communication of results on time to treatment initiation of microbiologically confirmed TB. |
KATHARINA KRANZER; | 2022-08-28 |
| 154 | A Phase II, Prospective, Randomized, Multicenter Trial to Evaluate The Efficacy and Safety/Tolerability of Two Linezolid Dosing Strategies in Combination With A Short Course Regimen for The Treatment of Drug-Resistant Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the efficacy (how well the medicines work) and tolerability (whether participants stop treatment because of side effects from a drug or treatment) of an anti-TB treatment regimen that compares two doses of linezolid (LZD), combined with bedaquiline (BDQ), delamanid (DLM), and clofazimine (CFZ). This study will also measure the level of these medicines in the participants’ blood. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2022-08-11 |
| 155 | Collision of Three Global Pandemics: The Effect of Tuberculosis and HIV on The Epidemiological, Clinical, Virological and Immunological Trajectory of COVID-19 in Botswana and Namibia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: COVID-19 has emerged as global pandemic during the past few months, with an unprecedented impact on public health, and society more generally. Virus epidemiology is poorly understood, … |
MARELI CLAASSENS; | 2022-08-01 |
| 156 | Evaluation of The Diagnostic Role of Enteroscopy in Small Intestinal Diseases at Al-Rajhi University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To identify the role of enteroscopy in diagnosis and treatment of small intestinal diseases. |
MAIADA MOHIE ELDIN IBRAHIM; | 2022-08-01 |
| 157 | A Parallel Group, Phase 2A, Randomised, Open Label, 4 Treatment Arm Study to Assess The Early Bactericidal Activity, Safety and Tolerability of Oral GSK3036656 in Combination With Either Oral Delamanid or Oral Bedaquiline, Oral Delamanid in Combination With Oral Bedaquiline, or Standard of Care in Males and Females Aged 18 to 65 Years Inclusive With Drug-sensitive (Rifampicin-susceptible) Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to measure the early bactericidal activity (EBA), safety, tolerability and pharmacokinetics with GSK3036656 in combination with either delamanid or bedaquiline, delamanid in combination with bedaquiline or standard of care for 14 days in participants with newly diagnosed sputum smear positive drug-sensitive pulmonary tuberculosis. Participants will revert to the standard treatment (RIFAFOUR® e-275) once the study treatment (Day 1 to Day 14) has been completed. RIFAFOUR e-275 is a registered trademark of Sanofi-Aventis |
VERONIQUE DE JAGER; | 2022-07-27 |
| 158 | Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy: Phase 2 Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate a combination of bedaquiline and rifampicin as post exposure prophylaxis (PEP) for leprosy in Comoros. It will be a follow-up to the PEOPLE trial on PEP with rifampicin, which is ending in 2022. This new trial will be called the ‘Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy’ or ‘BE-PEOPLE’ trial. There will be two main study arms, a comparator arm based on the current WHO recommendation of providing a single dose of rifampicin (10 mg/kg) to close contacts of leprosy patients and an intervention arm in which this regimen will be reinforced with bedaquiline, … |
YOUNOUSSA ASSOUMANI; | 2022-07-14 |
| 159 | Tunisian National Registry on Psoriasis PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: National cross-sectional multicentric study to describe the epidemiological characteristics of patients with Psoriasis in Tunisia |
DACIMA CONSULTING | 2022-07-12 |
| 160 | Randomized Controlled Trial Of A Health Belief Model-Based Intervention To Prompt To Take Up The Childhood Vaccines And Effect On Vaccination Attitudes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine the effect of pregnant women aged 18 years and older who have completed their 28th week of pregnancy and received intervention based on the Health Belief Model, on encouraging childhood vaccinations and influencing their vaccination attitudes, compared to pregnant women who receive standard care group. The 12-month vaccination rate of newborns and the change in their attitudes will be determined according to the Public Attitude Towards Vaccination Scale – Health Belief Model. |
KÜBRA SULTAN DENGIZ; | 2022-07-04 |
| 161 | HIV Transmission in The Era of Scaling Up Access to Antiretroviral Therapy in Ethiopia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to understand patterns of HIV transmission in a high-prevalence area in Ethiopia, and to compare viral genetic information in people with HIV who are newly diagnosed and have not been exposed to antiretroviral therapy with persons receiving antiretroviral therapy without viral suppression. The main questions it aims to answer are: * Do people with HIV who fail to achieve viral suppression contribute to the ongoing spread of HIV in Ethiopia, … |
PER BJÖRKMAN; | 2022-07-01 |
| 162 | Effect of Integrating Traditional Tuberculosis Care With Modern Health Care on Case Detection, Cost, and Client Satisfaction in Amhara Region, Ethiopia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Although many interventions are implemented to increase TB case detection, decrease diagnosis delay, and avoid catastrophic costs, there are no significant changes and the end TB goal will not be achieved in 2035. Innovative intervention that considers indigenous knowledge and unique culture and religious perspectives because many people go to traditional healers and holy water for healing. Therefore, integrating traditional tuberculosis care with modern care increase case detection, decrease diagnosis delay, and avoid catastrophic costs. There is no literature clearly defining integrating traditional TB care with modern care, but for the purpose of this study, … |
DESALEGNE AMARE; | 2022-07-01 |
| 163 | Role of Low Dose Steroids Vs Placebo in Addition to Anti-tuberculosis Treatment (ATT) in Regression of Lymph Node Sizes in Patients With Tuberculous Lymphadenopathy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted as a single blinded randomized control trial. The goal of this clinical trial is to learn about the role of low dose steroids in the resolution of tuberculous lymphadenitis. The prime questions, this clinical trial aims to answer are: – Is there any role of starting low dose steroids in resolution of lymph node size along side standard anti-tubercular drugs in patients of tuberculous lymphadenitis? – … |
FAHAD JAVED AWAN; | 2022-07-01 |
| 164 | The Effect of Vitamin D Supplementation on Toll-Like Receptor (TLR) 2, 4, and Clinical Outcomes of Spondylitis Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background : The toll-like receptor is an essential receptor that stimulates the innate immunity response. In tuberculosis, toll-like receptors, particularly the TLR-2, and TLR-4 are crucial in recognizing various ligands with a lipoprotein structure in the bacilli. Vitamin D deficiency leads to lower expression of these receptors, Hence the immune response against Mycobacterium tuberculosis will be altered. Various studies addressed the importance of vitamin D supplementation in pulmonary tuberculosis but the effect of vitamin D in extrapulmonary tuberculosis, particularly spondylitis tuberculosis is not sufficiently identified. Objectives: To assess the effect of oral vitamin D supplementation on the expression of TLR-2, … |
BUMI HERMAN; | 2022-07-01 |
| 165 | One-month Latent Tuberculosis Treatment for Renal Transplant Candidates PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, single-center, single-arm, open-label study investigating the safety, compliance and pharmacokinetics of 1-month treatment of Isoniazid, Rifapentine and Vitamin B6 in renal transplant candidates. |
PINKI BHATT; | 2022-07-01 |
| 166 | Evaluation of Antigen Rapid Diagnostic Tests (Ag-RDTs) for Community Identification of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Kiambu County, Kenya PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Background: Testing with antigen-detecting rapid diagnostic tests (Ag-RDTs), including in asymptomatic individuals, has the potential to promptly identify more Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections and consequently decrease spread of coronavirus-19 disease at the community level. In addition, rapid test results are important for immediate clinical management and isolation of patients with SARS-CoV-2 infection, and for contact tracing and quarantining of contacts. Data on SARS-CoV-2 infection rates, the acceptability of Ag-RDT, … |
ROSE OTIENO MASABA; | 2022-06-20 |
| 167 | Selected Concise Host Transcriptional Signatures for The Blood-based Diagnosis of Active Tuberculosis in An HIV-prevalent Setting (RNA-based Diagnosis of TB) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is the biggest infectious cause of death worldwide, and the biggest cause of death in Sub-Saharan Africa among HIV-positive patients. There is need for a non-sputum-based rapid triage test that identifies individuals with presumptive TB requiring confirmatory diagnostic investigation. Such a test could reduce the burden on health systems, expedite referral and confirmatory testing, and treatment thereby reducing transmission. A non-sputum triage test is needed as many symptomatic patients including those with HIV, … |
GRANT THERON; | 2022-06-20 |
| 168 | A Phase 2a Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety, and Tolerability of An Oral Tablet Formulation of JNJ-77242113 for The Treatment of Moderate-to-Severe Plaque Psoriasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the efficacy of an oral tablet formulation of JNJ-77242113 compared with placebo in participants with moderate-to-severe plaque psoriasis. |
JANSSEN RESEARCH & DEVELOPMENT | 2022-06-13 |
| 169 | A Single-centre, Open-label, Exploratory Study to Investigate The Pharmacokinetics of Ethionamide and Ethionamide Sulfoxide in Patients Established on Treatment for Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the pharmacokinetics of ethionamide (Eto) and ethionamide-sulfoxide (Eto-SO) in participants with tuberculosis (TB) when Eto is dosed under programmatic conditions. |
BIOVERSYS AG | 2022-06-10 |
| 170 | Training CHWs to Support Re-Engagement in TB/HIV Care in The Context of Depression and Substance Use PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up (LTFU) in HIV/TB care. Patients with depression and substance use (SU) have a greater likelihood of being LTFU in HIV/TB care, and there is evidence that CHWs may exhibit stigma towards these patients. When CHWs have negative attitudes towards these patients, on average they spend less time with these patients, are less likely to implement evidence-based practices, and deliver less patient-centered care. Therefore, … |
JESSICA F MAGIDSON; | 2022-06-08 |
| 171 | A Brief Educational Video for Patients Prescribed Latent Tuberculosis Treatment: A Randomized Trial in An Integrated Healthcare Organization in The United States PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Many patients who are prescribed treatment for latent tuberculosis (LTBI) do not complete treatment. Effective interventions that are low-cost and feasible for large-scale implementation are needed to support efforts to eliminate TB. The investigators hypothesize that a 3-minute educational LTBI video intervention will improve treatment completion compared to standard care (no intervention). A randomized trial will be conducted at Kaiser Permanente Southern California, including adults who are prescribed treatment for LTBI, identified using an electronic health record algorithm. At the time of treatment prescription, … |
KAISER PERMANENTE | 2022-06-03 |
| 172 | Performance Evaluation of The Molbio Diagnostics Truenat™MTB Plus/COVID-19for TB and COVID-19case Detection Using Prospectively Collected NP (Nasopharyngeal) Swabs and Sputum Samples From Participants With Symptoms Suggestive of TB PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, multicentre study in which the accuracy of the Molbio Diagnostics Truenat™ MTB (Mycobacterium tuberculosis) Plus/COVID-19multiplex will be assessed for TB and COVID-19 case detection using prospectively collected NP swabs and sputum samples from patients with symptoms suggestive of TB. The overall study period is of 24 months which includes telephonic follow-up of the baseline COVID-19negative patients at 2 weeks and of all participants at 2 months. |
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS SWITZERLAND | 2022-06-01 |
| 173 | A Multicenter Clinical Trial of Recombinant Human Interferon Gamma (Ingaron) in Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of testing: To confirm the effectiveness and safety of the drug Ingaron when used in patients hospitalized at the research center for various reasons. |
SPP PHARMACLON | 2022-06-01 |
| 174 | Effectiveness, Feasibility, And Usability Of Mobile Application To Improve Adherence To Tuberculosis Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is a major public health concern, where it is among the top ten causes of death and the leading cause of death due to a single infectious agent globally. Providing standard anti-TB therapy for at least six months is recommended as one of the important strategies to control TB epidemic. However, prolonged duration of TB treatment raised issues of non-adherence. Non-adherence to TB therapy could negatively affect clinical and public health outcomes. Introduction of Direct Observed Therapy (DOT) has been used as a standard strategy to improve anti-TB adherence. Nonetheless, … |
MOHD FAZELI BIN SAZALI; | 2022-06-01 |
| 175 | Efficacy of Tofacitinib in Vitiligo-a Randomized Controlled Trial in A Selected Tertiary Level Hospital in Dhaka PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Standard treatment for vitiligo often has unsatisfactory outcomes. With a new understanding of pathogenesis, novel drugs have been introduced which have shown to be effective in small-scale studies. Tofacitinib, a Janus kinase(JAK) inhibitor-2 has shown promising results in the treatment of vitiligo. However, … |
PI RESEARCH CONSULTANCY CENTER BANGLADESH | 2022-05-30 |
| 176 | Open-label Study to Evaluate The Pharmacokinetics, Safety, and Immunogenicity of Ustekinumab in Pediatric Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate pharmacokinetics (PK) of ustekinumab in juvenile psoriatic arthritis (jPsA) and pediatric psoriasis (PsO). |
JANSSEN RESEARCH & DEVELOPMENT | 2022-05-24 |
| 177 | INTEGrating Rapid Antigen TEsting for SARS-CoV-2 in Maternal, Neonatal and Child Health, HIV and Tuberculosis Services in Cameroon and Kenya: A Cluster Randomized Trial of Two Models PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Integration of antigen-detecting rapid diagnostic tests (Ag-RDT) for COVID-19 into services that provide care for vulnerable populations such as pregnant women, children, people with HIV infection, and patients with tuberculosis (TB) will identify more people with Coronavirus infection. This will allow for earlier treatment and tracing of contacts to decrease the spread of the coronavirus. This study is looking at two models for providing the testing in Maternal, Newborn and Child Health (MNCH), Tuberculosis (TB) and HIV clinics in Cameroon and Kenya. In some clinics, … |
NILESH BHATT; | 2022-05-17 |
| 178 | A Clinical Challenge Study to Evaluate Controlled Human Infection With BCG Administered By The Aerosol Inhaled Route in Historically BCG-vaccinated Healthy Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the human clinical response to BCG challenge in historically BCG-vaccinated healthy adult volunteers. It will involve 12 participants in a controlled dose escalation. Bronchoscopies will be performed 14 days post-challenge to measure BCG recovered from bronchial samples. Blood tests will be taken to look at potential immunological markers of immunity. |
HELEN MCSHANE; | 2022-05-17 |
| 179 | Impact of Rifabutin on The Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, single-center, fixed-sequence, nonrandomized, open-label study in healthy adults to investigate the impact of rifabutin on the pharmacokinetics of trikafta. |
PAUL BERINGER; | 2022-05-09 |
| 180 | Randomized Controlled Trial Comparing Diagnostic Yield for Small Bowel Endoscopy Between Novel Motorized Spiral and Single Balloon Enteroscopy in Suspected Crohn’s Disease (the MOTOR-CD Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Both single-balloon enteroscopy (SBE) and novel motorized spiral enteroscopy (NMSE) are effective techniques for small bowel endoscopy in suspected Crohn’s disease (CD). Small bowel endoscopy is indicated for confirming diagnosis when CD is suspected based on clinical features along with cross-sectional small bowel imaging (computed tomography enterography/enteroclysis: CTE or magnetic resonance enterography/enteroclysis: MRE) or capsule endoscopy (CE). It not only helps in diagnosing CD, but it also helps in excluding CD, diagnosing alternate conditions and taking a surgical decision if a tight stricture is found. The pilot study done by the investigators in 177 suspected CD patients (37.2% female, … |
ASIAN INSTITUTE OF GASTROENTEROLOGY INDIA | 2022-05-07 |
| 181 | Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens Into The Human Lung PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Tuberculosis (TB) is a lung disease. It is caused by inhaling a type of airborne bacterium. Tuberculin Purified Protein Derivative (PPD) is used to test for TB exposure. It is usually injected under a person s skin. In this study, it will be applied in the lung. Objective: To learn how the cells within the lung react (immune response) when exposed to PPD. Eligibility: Adults ages 18-64 who (1) have been exposed to TB but do not have active disease or symptoms or (2) have never been exposed to TB. Design: Participants will be screened with a medical history, … |
IFEANYICHUKWU U ANIDI; | 2022-05-03 |
| 182 | ANRS 12424: Determination of Adequate Tuberculosis Regimen in Adults and Adolescents Hospitalized With HIV-associated Severe Immune Suppression (CD4 ≤ 100 Cells/µL): The DATURA Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: DATURA trial is a phase III, multicenter, two-arm, open-label, randomized superiority trial to compare the efficacy and the safety of an intensified tuberculosis (TB) regimen versus standard TB treatment in HIV-infected adults and adolescents hospitalized for TB with CD4 ≤ 100 cells/μL over 48 weeks: * Intensified TB treatment regimen: increased doses of rifampicin and isoniazid together with standard-dose of pyrazinamide and ethambutol for 8 weeks in addition to prednisone for 6 weeks and albendazole for 3 days * WHO standard TB treatment regimen. The continuation phase of TB treatment will be identical in the two arms: 4 months of rifampicin and isoniazid at standard doses. |
BLANC FRANÇOIS-XAVIER; | 2022-04-21 |
| 183 | A Phase 2 Trial to Evaluate The Early Bactericidal Activity, Safety and Tolerability of Sanfetrinem Cilexetil Administered Orally to Adults With Newly Diagnosed, Smear-Positive, Rifampicin-Susceptible Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the 2-week bactericidal activity, pharmacokinetics, safety and tolerability of sanfetrinem cilexetil in participants with rifampicin-susceptible pulmonary tuberculosis. |
TASK APPLIED SCIENCE | 2022-04-21 |
| 184 | Automated Smartphone-based Cough Audio Classification for Rapid Tuberculosis Triage Testing (Cough Audio TriaGE for TB; CAGE-TB) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: TB is the single biggest infectious cause of death (1.5 million died in 2018), killing more HIV-positive people than any other disease, and is arguably the most important poverty-related disease in the world. TB’s estimated incidence in Africa has been declining over recent years but progress is slow and plateauing. To avert stagnation, truly innovative and ambitious technologies are needed, especially those that improve case finding and time-to-diagnosis as, in mathematical models based on the TB care cascade framework, interventions that accomplish this will have the most impact on disrupting population-level transmission, … |
GRANT THERON; | 2022-04-19 |
| 185 | The Effect of The Combination of Excision and Intraoperative Steroid Administration in Idiopathic Granulomatous Mastitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: After breast cancer, diopathic Granulomatous Mastitis (IGM) is among the breast diseases that bother patients and clinicians the most. Countries with a coast to the Mediterranean, especially our country, are the most common geography of this disease. For this reason, a significant part of the important scientific publications about IGM in the last 3-4 decades are from the countries of this geography and mainly from our country. The paradigm of whether IGM should be treated medically or surgically is still a matter of debate. Today, effective treatment results can be achieved with medical treatments, … |
HUSEYIN OZGUR AYTAC; | 2022-04-16 |
| 186 | An Open Prospective Observational Study Evaluating The Efficacy and Tolerability of Interferon Gamma (Ingaron) Injections in Patients With Drug-resistant Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and tolerability of the complex therapy of drug-resistant respiratory tuberculosis using the drug Ingaron, a lyophilisate for the preparation of a solution for injection for intramuscular or subcutaneous administration of 500,000 IU. |
SPP PHARMACLON | 2022-04-15 |
| 187 | A Multicenter, Phase 2b/c, Open-label, Randomized, Dose-finding Trial to Evaluate The Safety and Efficacy of A 4 Month Regimen of OPC-167832 in Combination With Delamanid and Bedaquiline in Subjects With Drug-susceptible Pulmonary Tuberculosis in Comparison With Standard Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial will assess the safety and efficacy of OPC-167832 combined with delamanid and bedaquiline in participants with drug-susceptible tuberculosis (DS-TB) administered for 17 weeks compared to rifampin, isoniazid, ethambutol, pyrazinamide (RHEZ) administered for 26 weeks. |
OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION | 2022-04-12 |
| 188 | Tuberculosis – Learning The Effect of Parasites and Reinforcing Diets (TB-LEOPARD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this research are to determine: * the burden of intestinal parasitic infections among persons living with pulmonary tuberculosis (TB) * whether intestinal parasitic infections alter TB treatment outcomes, … |
PRANAY SINHA; | 2022-04-09 |
| 189 | Comparison of 3-month Once-weekly Isoniazid Plus Rifapentine, 4-month Daily Rifampicin, and 3-month Daily Isoniazid Plus Rifampicin for The Treatment Latent Tuberculosis in Patients With End-stage Kidney Disease: A Randomised Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective To determine if treatment completion with a 4-month rifampin (4R) or 3-month rifapentine (P) + isoniazid (H) weekly for 12 weeks (3HP) regimens is better than with a 3-month (3HR) regimen for treatment of latent tuberculosis (TB) infection (LTBI) in patients with end stage kidney disease. Methods Design: Multicenter, prospective, parallel-group, open-label, controlled clinical trial. Study population: All adult patients with ESKD in who treatment for LTBI is prescribed at 7 hospitals. Interventions: Patients who accept participation, will be randomly assigned to one of the 3 arms: 3HR (control) (90 doses), … |
MIGUEL SANTÍN; | 2022-04-01 |
| 190 | The Prophylaxis of Tuberculosis According to TSPOT Results After Kidney Transplantation (PTTKT):Protocol for An Open-label, Prospective, Randomized, 3-arm, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Organ transplant recipients are a high incidence group of tuberculosis infection, and the incidence rate is 7-27 times that of the general population. The prevention of postoperative tuberculosis infection is an important part of kidney transplant recipients postoperative follow-up. Taking reasonable tuberculosis prevention strategies for organ transplant recipients can better prevent the occurrence of postoperative tuberculosis and reduce the unreasonable use of anti-tuberculosis drugs. The previous screening methods for active tuberculosis mainly include sputum smear culture, tissue biopsy, tuberculin skin test, tuberculosis antibody, tuberculosis DNA, and chest imaging. However, … |
TAO LIN; | 2022-04-01 |
| 191 | A Prospective, Self-controlled Study to Explore Efficacy and Safety of Orelabrutinib in AQP4-IgG Positive Neuromyelitis Optica Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Neuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory demyelinating autoimmune disease of the central nervous system. NMOSD is a highly relapsing, severely disabling disease. AQP4-IgG positive NMOSD is related to a specific aquaporin 4 antibody (AQP4 IgG) produced by mature B cells. BTK is a key kinase in B cell receptor signal transduction pathway. Abnormal activation of BTK related signaling pathway can lead to autoantibody production and autoimmune diseases. Therefore, BTK can be developed as a new target for autoimmune diseases. |
YAN XU; | 2022-04-01 |
| 192 | Evaluating The Sequelae of Pulmonary Tuberculosis in Gambian Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to describe the long-term adverse outcomes associated with PTB in children, to describe the evolution of these sequelae, and to determine the epidemiological risk factors associated with these sequelae. We will conduct a prospective cohort study. Children who have completed treatment for PTB will be enrolled. The study visit will be performed in the study clinic where clinical assessment, spirometry and radiography will be performed. The planned duration of the study is 36 months. Participant enrolment is estimated to begin in March 2022. Estimated date of last participant enrolled is December 2022. |
ESIN NKEREUWEM; | 2022-03-29 |
| 193 | Comparing Novel Methods of Study Information Notice Administration to The Standard Approach in Enhancing Clinical Studies Understanding in Resource Limited Settings: A Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized trial in which participants are assigned to one of 2 strategies of information notice administration which include the standard approach versus a video-based cartoon approach. An information notice about the study will be administered to each participant individually. The study involves the integration of tuberculosis screening at all pediatric entry points, and other activities aimed at improving pediatric tuberculosis diagnosis and management. The understanding of participants will be assessed using a test of understanding adapted from the Quality of Informed consent (QIC). |
BORIS K TCHOUNGA; | 2022-03-28 |
| 194 | Safety and Tolerability of Ultra-short Course Rifapentine and Isoniazid (1HP) for Prevention of Tuberculosis in HIV-Uninfected Individuals PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare treatment success (adherence and completion of treatment) and safety of 1HP with 3HP in HIV-uninfected adults and adolescents at increased risk of TB. |
RICHARD CHAISSON; | 2022-03-24 |
| 195 | Time-to-Detection in Culture of Mycobacterium Tuberculosis : Performance for Assessing Index Cases Infectivity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: determination if time-to-detection in cultures of M. tuberculosis samples is more discriminating than acid-fast staining in transmission |
CENTRE HOSPITALIER UNIVERSITAIRE DE NICE | 2022-03-15 |
| 196 | Leveraging MHealth to Enable and Adapt Community Health Worker Strategies to Improve TB/HIV Patient Outcomes in South Africa (LEAP-TB-SA) Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: mHealth solutions designed to support affordable human resources for health, such as community health workers (CHWs), offer the opportunity to reimagine a patient-centered, system-level solution that may radically change care models in low resource settings. The ‘leap’ of m-health is most potent and practical in settings where desktop-based infrastructure is lacking and hard-wired internet connectivity is unavailable. Investigators have demonstrated the feasibility of mHealth and human resource solutions in South Africa and shown marked improvements in screening, … |
JASON E FARLEY; | 2022-03-10 |
| 197 | Human-centered Design and Communities of Practice to Improve Delivery of Home-based Tuberculosis Contact Investigation in Uganda PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: In a previous randomized control trial, the investigators identified gaps in the implementation of tuberculosis (TB) contact investigation at multiple levels of the service delivery cascade. Drawing on prior experiences, the investigators have recently developed a novel strategy to enhance the implementation of routine contact investigation procedures. This user-centered implementation strategy was created through serial prototyping guided by human-centered design (HCD) and employs communities of practice (CoP) as an adjunctive adaptation and sustainment strategy. The investigators are now conducting a stepped-wedge, … |
J. LUCIAN DAVIS; | 2022-03-07 |
| 198 | Comparison of Efficacy of Ketogenic Diet and ACTH Therapy Among Children With West Syndrome: A Pilot Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Children with West syndrome are prone to refractory seizures with poor neurocognitive outcome overall. The current standard of care consists of treatment with ACTH, but the grade of evidence is not high and not much RCTs are available. Ketogenic diet is an effective and well tolerated treatment option in drug refractory epilepsy and also in refractory west syndrome. In view of minimal side effects, … |
SHEFFALI GULATI; | 2022-03-01 |
| 199 | COVID-19, Patients’ Evolution and The Influence of The Pandemic on Health Care and Outcomes in Chronic PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: 1.- To evaluate the changes in health care and use of services in patients with chronic diseases such as chronic obstructive pulmonary disease (COPD), heart failure and major depression between 2017-2019 and the years 2020-2022, COVID pandemic period, and to see their relationship with clinical outcomes (in terms of mortality, admissions, death, current situation of his disease) and changes in health-related quality of life. 2- To evaluate the health care provided to a cohort of patients diagnosed with SARSCOV-2 (COVID-19 positive) during 2020 based on accessibility, … |
JOSE M QUINTANA-LOPEZ; | 2022-02-28 |
| 200 | Evaluating The Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19 PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is now the commonest cause of death in many African countries. Globally, ~35% (almost 1 in 3) of TB cases are ‘missed’ (remain undiagnosed or undetected). In sub-Saharan Africa, 40-50% of the TB case burden remains undiagnosed within the community. These ‘missed’ TB cases (at primary care level) serve as a reservoir, which severely undermines TB control. With rapid advances in the development of TB screening tests, the investigators aim to determine the pragmatic utility of computer-assisted x-ray diagnosis (CAD). Recent data suggest that CAD performs on par with experienced radiologists to identify potential TB cases, … |
KEERTAN DHEDA; | 2022-02-23 |
| 201 | A Phase 2b Study to Evaluate The Efficacy, Safety and PK of A Combination of Bictegravir, Emtricitabine, and Tenofovir Alafenamide Fumarate for Treatment of HIV-1 Infection in Patients With DS-TB on A Rifampicin-based Regimen PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being conducted to assess the antiretroviral activity of a fixed-drug, single tablet, combination of Bictegravir 50mg/ Emtricitabine 200mg/ Tenofovir alafenamide 25mg (Biktarvy®) dosed twice daily in HIV-1 infected, ART-naïve patients with TB co-infection receiving a rifampicin-based tuberculosis (TB) treatment regimen. This study will assess the activity of Bictegravir and dolutegravir-containing ART regimens in patients with drug-susceptible TB through 48 weeks |
ANUSHKA NAIDOO; | 2022-02-18 |
| 202 | A Special Drug Use-results Survey to Evaluate The Safety and Efficacy of Subcutaneous Administration of Cosentyx in Pediatric Patients With Psoriasis Vulgaris, Psoriatic Arthritis, or Pustular Psoriasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, centrally registered observational study without a control group. This observational study is a specified drug use-results survey conducted under GPSP to collect information on safety and efficacy during the observation period (52 weeks after the start of treatment with this drug) in pediatric patients with psoriasis vulgaris, psoriatic arthritis, or pustular psoriasis who received this drug. |
NOVARTIS PHARMACEUTICALS | 2022-02-14 |
| 203 | A Phase Ⅱ Study on The Safety, Tolerability and Immunogenicity of The Recombinant Mycobacterium Tuberculosis Vaccine Freeze-dried PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The safety, tolerability and immunogenicity of lyophilized recombinant tuberculosis vaccine (AEC/BC02) were studied in a randomized, blind, controlled phase ⅱ A clinical study in patients 18 years and older with latent infection of Mycobacterium tuberculosis.Twenty patients with negative control group and 180 patients with latent mycobacterium tuberculosis infection were divided into sentinel group, placebo group, high-dose adjuvant group, low-dose vaccine group, high-dose vaccine group and high-dose vaccine group (three doses).During the test, each subject shall not change groups or receive drugs.The negative control group did not take chemical drugs and did not get vaccinated after enrollment, … |
TAO HUANG; | 2022-02-10 |
| 204 | Airway Microbiome and Th17-mediated Inflammation in COPD Among HIV-infected Individuals in A Rural Ugandan Cohort PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: COPD is increasing in prevalence among people living with HIV/AIDS (PLWHA) as widespread use of ART has increased longevity in this population. In rural Ugandan ART clinics, we report COPD prevalence of 6.22%. Currently, it’s not fully known what drives chronic lung inflammation in PLWHA population despite being virologically suppressed on ART. There is need to explore factors driving chronic airway inflammation among PLWHA. Airway microbiome has been implicated in the pathogenesis of COPD. Preliminary analysis from our study revealed that, … |
ALEX KAYONGO; | 2022-02-01 |
| 205 | Tuberculosis Drug Levels and Continuous Glucose Monitoring in Diabetic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes significantly increases the risk of developing active tuberculosis (TB). Diabetic patients who do develop TB have worse treatment outcomes and overall mortality. TB also worsens blood glucose control in diabetics, the mechanism of which is not well understood. The incidence of type 2 diabetes is rising globally, and consequently diabetes and TB co-infection is increasingly common, … |
ANN STURDY; | 2022-02-01 |
| 206 | Diagnostic Accuracy of Imaging Findings in Tubercular Meningitis/Spinal Tubercular Arachnoiditis and Correlation With Outcomes in Patients With Tubercular Meningitis, Spinal Tubercular Arachnoiditis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this Diagnostic accuracy study is – To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and – To study the correlation of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis with clinical outcomes after completion of therapy – Secondary objectives – To study the proportion of patients having clinical or imaging features of spinal tubercular arachnoiditis – To study the factors determining outcomes in patients with spinal tubercular arachnoiditis – … |
ARUNMOZHIMARAN ELAVARASI; | 2022-01-27 |
| 207 | Pharmacokinetics of Drugs Used to Treat Drug-sensitive Tuberculosis in Breastfeeding Mother-infant Pairs: An Observational Pharmacokinetic Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pregnant or lactating women requiring treatment for drug sensitive-TB will be identified and invited for sampling. If they are pregnant when identified, they will be invited for sampling after delivery. Plasma and breastmilk samples will be obtained pre-dose and at 2, 4, 6, and 8 hours post-dose. If logistics permit (for example living close to the research unit), … |
CATRIONA WAITT; | 2022-01-20 |
| 208 | Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was a randomized controlled trial studying about acid-fast bacillus sputum conversion ratio from positive to negative of pulmonary tuberculosis patients between metformin with pulmonary tuberculosis standard treatment group and placebo drug with pulmonary tuberculosis standard treatment. |
ANGSANA PHUPHUAKRAT; | 2022-01-15 |
| 209 | Evaluation of The Specificity of Intradermal Test With Recombinant Tuberculosis Allergen in BCG Vaccinated Healthy Volunteers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to test the recombinant tuberculosis skin test in the previously BCG vaccinated healthy adults with low risk of TB development, to determine the test specificity. |
ALEKSEY V. KAZAKOV; | 2022-01-10 |
| 210 | IMPI-3 – A Randomized Controlled Trial of High Vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators hypothesise that high dose RIF (RIF35) will increase pericardial fluid RIF exposure and so enhance mycobacterial clearance, compared to standard of care dosing (RIF10). This Phase 2b randomized, placebo-controlled, double-blinded trial will evaluate the efficacy and safety of RIF 35mg/kg compared 10mg/kg, added to standard first-line ATT, for the treatment of PCTB. |
MPIKO NTSEKHE; | 2022-01-10 |
| 211 | Open Label, Single Center, Phase 1 Dose Escalation and Extension Trial to Evaluate Safety and Tolerability of Chlorquine As Adjuvant Drug to Standard 4-drug Anti-tuberculosis Therapy in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In vitro and in vivo data show promising results of adjunctive use of Chloroquine to standard tuberculosis therapy as Chloroquine enhances animicrobial effectiveness against intracellular MTB. To date, no safety data of the concurrent use of both treatments is availble. In a phase I trial, the investigators aim to evaluate safety and tolerability of the concurrent use of Chloroquine and standard anti-TB drug in healthy volunteers. |
MARISA KAELIN; | 2022-01-04 |
| 212 | A Phase IIA Randomized Double-blind Placebo-controlled Single-centre Study of The Effect of Bacillus Calmette-Guérin (BCG) Vaccination on The HIV Latent Reservoir PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Background and Rationale: HIV infection affects around 40 million people globally and is incurable due to persistence of viral genetic material within the host genome as the … |
JOHANNES NEMETH; | 2022-01-04 |
| 213 | Validating The Use of Blood Transcriptomic Signatures for The Diagnosis of Active Pulmonary Tuberculosis With The ISIT-TB Prototype in Adults Living in A High Burden Setting PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: ISIT-TB Prototype is a diagnostic assay based on a transcriptional blood signature suggestive of the detection of Mycobacterium tuberculosis. |
KEERTAN DHEDA; | 2022-01-03 |
| 214 | Safety and Immunogenicity of Three Doses of An Inactivated SARS-CoV-2 Vaccine in Chinese Pulmonary Tuberculosis Patients Aged 18-75 Years: A Randomized, Double-blind, Parallel-controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, parallel-controlled study, for evaluation of safety and immunogenicity of three doses of an inactivated COVID-19 vaccine (CoronaVac) in pulmonary tuberculosis patients aged 18-75 years. 200 tuberculosis patients and 40 healthy adults aged 18-75 years will be recruited in this study. Of them, 200 pulmonary tuberculosis patients will be randomized at a 1:1 ratio to receive two doses of standard dosage CoronaVac plus one dose of double dosage CoronaVac or two doses of standard dosage CoronaVac plus one dose of standard dosage CoronaVac at a schedule of 0, 28, 56 days, … |
JING-XIN LI; | 2021-12-22 |
| 215 | New Strategies for Assessment of The Persistence of Viable Bacilli in Latent and Active Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Current diagnostic tools such as interferon gamma release assay (IGRA) and purified protein derivative (PPD) can not distinguish patients with latent tuberculosis infection (LTBI) and persistence of live mycobacteria. This inability to rule out living mycobacteria in patients investigated for LTBI leads to unnecessary and potentially harmful treatment regimes all around the globe. The goal of this observational study is to identify candidate biomarkers for viable bacilli in latent tuberculosis in order to decrease the use of unnecessary and ineffective antibiotic treatment. |
PER BJÖRKMAN; | 2021-12-21 |
| 216 | A Multi-country, Epidemiologic Study to Assess The Interferon Gamma Release Assay (IGRA) Positivity, and to Build Capacity to Conduct A Tuberculosis (TB) Vaccine Efficacy Study, in Populations With A High TB Disease Burden PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to conduct a multi-country, multi-site, epidemiologic study designed to assess the proportion of interferon gamma release assay (IGRA) positivity, at site level, and to build capacity to conduct a future TB vaccine efficacy study. |
BILL & MELINDA GATES MEDICAL RESEARCH INSTITUTE | 2021-12-20 |
| 217 | ENose-TB: Electronic Nose for Tuberculosis Screening in Indonesia PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: An electronic-nose (e-nose) had been investigated as a diagnostic tool for tuberculosis by examining exhaled breath of the patients. Universitas Gadjah Mada has developed an e-nose device for TB diagnostic tool. Here the investigators test the device in order to analyze the sensitivity and specificity electronic-nose as a screening tool for tuberculosis. |
YODI MAHENDRADHATA; | 2021-12-02 |
| 218 | A Proof-of Concept, Randomized, Controlled Study of Tuberculosis Immunization With BCG to Prevent Infection in Healthy Adults (TIPI Trial) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG can lessen tuberculosis (TB) infection by producing an immune response when given to adults traveling to countries with a high burden of TB. BCG will be compared with a placebo (an inactive vaccine). BCG (Japan) is used globally but is not approved for use in the United States, therefore it is considered experimental. Participants choosing to take part in this research study, will be randomly assigned (this is like a coin flip) to BCG or placebo. 2000 eligible volunteers will be enrolled. |
PAUL GOEPFERT; | 2021-12-01 |
| 219 | The Prevalence of Genital Tuberculosis and The Impact on Reproductive Outcomes in Infertile Women: A National Multicenter Prospective Cohort Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Female genital tuberculosis infection (FGTB) is an important cause of female infertility in TB-endemic areas. The pregnancy rate of assisted reproductive treatment (ART) in the infertile women with FGTB is still unsatisfied even after receiving standard anti-tuberculosis treatment. Moreover, recent years have witnessed an alarming increase in reports of FGTB-related maternal and neonatal complications after fertility treatments. These underscore that timely detection and treatment of FGTB before ART hold benefit for the mother and child. |
WEN-HONG ZHANG; | 2021-12-01 |
| 220 | Evaluating A New Stool Based QPCR for Diagnosis of Tuberculosis in Children and People Living With HIV PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Stool4TB aims to evaluate an innovative stool-based qPCR diagnostic platform (with the capacity to become a POC diagnostic tool) in the high TB and HIV burden settings of Mozambique, Eswatini and Uganda, under the hypothesis that it will narrow the extremely large TB case detection gap by improving TB confirmation rates in children and people living with HIV (PLHIV). |
ALBERTO L GARCÍA-BASTEIRO; | 2021-12-01 |
| 221 | Utilizing The Crosstalk Among Chicoric Acid, 13-Cis Retinoic Acid(Aerosolized), Minocycline and Vitamin D As A Potent Quadrate Therapy for Treating Patients With Multidrug-resistant TB and Patient With Both Multidrug-resistant TB and COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Utilizing the Crosstalk Among Chicoric Acid, 13-Cis Retinoic Acid(Aerosolized), Minocycline and Vitamin D as a Potent Quadrate Therapy for treating patients with Multidrug-resistant TB and patient with both Multidrug-resistant TB and COVID-19 . A double-edged sword Clinical Study I)Part of Tuberculosis Tuberculosis (TB) is a major infectious disease killer globally. It affected 10 million and killed 1.4 million people in 2019 alone. The predicted impact of the COVID-19 pandemic is an additional 190,000 TB deaths in 2020, … |
MAHMOUD RAMADAN MOHAMED ELKAZZAZ; | 2021-12-01 |
| 222 | A Phase IIb Study to Explore The Efficacy and Safety of The Concomitant Administration of RUTI® Immunotherapy With The Standard Treatment in Patients With TB Related Papers Related Patents Related Grants Related Experts View Highlight: The study is an exploratory clinical trial to evaluate the efficacy and safety of the treatment with a vaccine against tuberculosis (RUTI®) given at the same time as standard treatment in patients with tuberculosis. It is a prospective, randomized (1:1), double-blind, multicentre, placebo-controlled clinical phase IIb trial. |
ARCHIVEL FARMA S L | 2021-12-01 |
| 223 | Randomized Clinical Trial: IS Zinc and Zinc Ionophere EGCG As Supplement Improve Outcome of Active Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis is still global burden disease at all the word and effect on quality life of patients and affect on health authorities because the cost of medicine and health cost . – A total of 1.4 million people died from TB in 2019 (including 208 000 people with HIV). Worldwide, TB is one of the top 10 causes of death and the leading cause from a single infectious agent (above HIV/AIDS). – In 2019, an estimated 10 million people fell ill with tuberculosis (TB) worldwide. 5.6 million men, … |
AMR KAMEL KHALIL AHMED; | 2021-11-30 |
| 224 | Video-observed Therapy (vDOT) As A Surrogate to Directly Observed Therapy (DOT) for Active Tuberculosis: A Feasibility Study in A Low Incidence High-income Area PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is still present in Switzerland, and concerns mainly foreign-born subjects. Monitoring compliance to treatment by Directly Observed Therapy (DOT) is strongly encouraged by the World Health Organization (WHO). It is however time-consuming, costly and stigmatising. This study aims to examine the feasibility of monitoring compliance through a secured web platform and videos sent via an application on a cellphone, a concept known as vDOT (Video-observed therapy). The study aims to include all patients treated for tuberculosis is on our area during an 18 month period and monitor acceptance, compliance, and technical issues related to vDOT. |
JEAN-PAUL JANSSENS; | 2021-11-26 |
| 225 | Active Case Finding Using Mobile Vans Equipped With Artificial Intelligence Aided Radiology Tests and Sputum Collection for Rapid Diagnostic Tests to Reduce Tuberculosis Prevalence Among High-risk Populations in Rural China: A Pragmatic Cluster Randomized Controlled Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to find out if using mobile vans with advanced technology can help reduce tuberculosis (TB) in rural Guangxi, China. The study will also examine how practical and cost-effective this approach is. The main questions it aims to answer are: 1) Does this new screening method lower the number of TB cases among high-risk groups? and 2) Is this method practical and acceptable for communities and healthcare workers? Participants in the study will: 1) undergo TB screening with mobile vans that use artificial intelligence (AI) to read chest X-rays, … |
XIAOLIN WEI; | 2021-11-20 |
| 226 | Cross-sectional Study on Prevalence of Latent Tuberculosis Infection in Health-care Workers and Students. A GENERATOR Infrastructure PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a cross-sectional study that examines the prevalence of Latent Tuberculosis Infection [LTBI], defined as individuals infected with Mycobacterium tuberculosis with no clinical evidence of disease, and the possible risk factors of LTBI in a large cohort of health care workers (HCWs) and students. |
ELEONORA NUCERA; | 2021-11-17 |
| 227 | PredicTB: Validating A Clinical Risk Score for Early Management of Tuberculosis in Ugandan Primary Health Clinics PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Although curative treatment exists, tuberculosis (TB) remains the leading cause of infectious mortality worldwide – often because people seek care for TB symptoms in highly resource-constrained clinics that cannot provide same-day diagnostic testing. The research team has developed an easy-to-use clinical risk score that, if implemented in these settings, might help clinicians identify patients at high risk for TB and thereby start treatment for those patients on the same day. This study will investigate the effectiveness and implementation of this score in four peri-urban clinics in Uganda, … |
DAVID W DOWDY; | 2021-11-10 |
| 228 | A Phase 1b Study to Evaluate The Efficacy and Safety of JNJ-64251330, A Janus Kinase (JAK) Inhibitor, in Participants With Familial Adenomatous Polyposis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the effect of JNJ-64251330 in participants with Familial Adenomatous Polyposis (FAP) on colorectal polyp burden (sum of the polyp diameters). |
JANSSEN RESEARCH & DEVELOPMENT | 2021-11-10 |
| 229 | Women’s MHealth Program: Nthabi Application in Lesotho PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will determine how well the mobile health (mHealth) Nthabi application is introduced and used at district hospitals in Lesotho. This will help with measuring the effectiveness of an evidence-based mHealth application in a low-income country. Three factors will be studied when assessing the mHealth application’s overall impact: 1) end-user content knowledge 2) pre and post stage of change and 3) system usage. This data will be collected by the mHealth application. End-users will use the mHealth application over a period of two months. Results will be shared with the clinical, health services research, information technology, and policy communities. |
BRIAN JACK; | 2021-11-08 |
| 230 | A Feasibility Study Evaluating The Prognostic and Logistic Value of Measuring D-dimer Levels in Primary Care Using (POC) Tests PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: DESTINY D-Dimer is an observational feasibility study, and a collaboration between the University of South Wales and Cwm Taf Morgannwg University Health Board (CTMUHB). The study is based at St. John’s Medical Practice in Aberdare, where participant recruitment will take place. Blood D-dimer data will be collected from CTMUHB Pathology Laboratory services, at Prince Charles Hospital. Study blood samples will be obtained by the research student, LAH, … |
UNIVERSITY OF SOUTH WALES | 2021-10-26 |
| 231 | Interrupting HIV and TB Stigma in The Household During TB Contact Investigation in Uganda PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will carry out a prospective, household cluster-randomized, implementation trial evaluating a complex, multi-component, social and behavioral intervention designed to normalize the acceptance of HIV testing in the household and increase diagnosis of HIV. |
J. LUCIAN DAVIS; | 2021-10-25 |
| 232 | Cryospray Therapy for Benign Airway Stenosis: A Randomized Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Benign central airway stenosis (BCAS) is an important cause of both pulmonary morbidity and mortality. Notable causes include post-intubation stenosis, collagen vascular diseases, airway trauma, infectious and idiopathic subglottic stenosis (iSGS). Surgery is the preferred definite option; however, the first therapeutic attempt is usually endoscopic to temporarily restore airway patency and symptomatic improvement. Several endoscopic modalities exist for treatment. Most commonly, thermal or laser therapy to make radial incisions into the stenotic lesion, … |
ANKUSH RATWANI; | 2021-10-25 |
| 233 | A Phase 2a, Multicenter, Randomized, Double-blind Study Evaluating The Efficacy and Safety of Subcutaneously Administered Guselkumab and Golimumab Combination Therapy in Participants With Active Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of guselkumab plus golimumab combination treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) to prior anti-tumor necrosis factor-alpha (anti-TNF-alpha) therapies by assessing clinical response compared with guselkumab monotherapy. |
JANSSEN RESEARCH & DEVELOPMENT | 2021-10-25 |
| 234 | A Phase IIb, Open Label, Randomized Controlled Dose Ranging Multi-Center Trial to Evaluate The Safety, Tolerability, Pharmacokinetics and Exposure-Response Relationship of Different Doses of Delpazolid in Combination With Bedaquiline Delamanid Moxifloxacin in Adult Subjects With Newly Diagnosed, Uncomplicated, Smear-Positive, Drug-sensitive Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial is to describe the safety, tolerability and exposure-toxicity relationship of Depazolid given over 16 weeks, in combination with standard-dose Bedaquiline, Delamanid and Moxifloxacin, compared to standard-dose Bedaquiline, Delamanid and Moxifloxacin alone |
LEGOCHEM BIOSCIENCES | 2021-10-22 |
| 235 | A Phase 3, Multicenter, Open-label, Basket, Long-term Extension Study of Ustekinumab in Pediatric Clinical Study Participants (2 to <18 Years of Age) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to collect long-term safety data of subcutaneous (SC) ustekinumab |
JANSSEN RESEARCH & DEVELOPMENT | 2021-10-18 |
| 236 | COVID-19 Booster Vaccination in Persons With Multiple Sclerosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The success of the U.S. vaccination program against SARS-Cov-2 is shown by a dramatic drop in infection rates, hospitalizations and deaths.However, it appears that many persons who take medications that chronically suppress the immune system do not produce neutralizing antibodies to COVID-19 proteins in response to vaccination. This group includes a significant number of persons with multiple sclerosis (PWMS), … |
JOSEPH B GUARNACCIA; | 2021-10-15 |
| 237 | Point-of-care Ultrasound for The Diagnosis and Risk Stratification of Lower Respiratory Tract Infections in TB Endemic Regions: A Multicenter Prospective Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In Sub-Saharan Africa, lower respiratory tract infections (LRTIs) and tuberculosis (TB) jointly are the leading cause of overall mortality. There is a need to integrate sustainable triage and management strategies into standard care. The TrUST study investigates the utility of point-of-care ultrasound (POCUS) for diagnosis and prognosis of LRTIs in TB endemic regions in the outpatient triage setting. Automated interpretation of POCUS by artificial intelligence (AI) may further standardize and improve its predictive utility as well as facilitate its implementation into usual practice. |
BOILLAT-BLANCO NOEMIE; | 2021-10-14 |
| 238 | Long-term Health After Severe Acute Malnutrition in Children and Adults: The Role of The Pancreas PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Whilst there is an increasing prevalence of overweight and obesity worldwide, malnutrition remains common. In addition, malnutrition, overweight, and infections often interact. The consequences of malnutrition after birth are little studied. Severe acute malnutrition in childhood remains common in Africa and Asia and many adult patients with tuberculosis or HIV, diseases which are common in Africa and Asia, may become malnourished. We are interested in diabetes, … |
SUZANNE FILTEAU; | 2021-10-12 |
| 239 | A Phase 2a/2b, Multicenter, Randomized, Placebo and Active Comparator-controlled, Double-Blind, Dose-ranging Study to Evaluate The Safety and Efficacy of Bermekimab (JNJ-77474462) for The Treatment of Subjects With Moderate to Severe Hidradenitis Suppurativa PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the clinical efficacy of bermekimab in participants with moderate to severe Hidradenitis Suppurativa (HS). |
JANSSEN RESEARCH & DEVELOPMENT | 2021-10-12 |
| 240 | Evaluate The Effectiveness, Safety and Tolerability of Various Doses of Linezolid in Combination With Bedaquiline and Pretomanid in Adults With Pre-Extensively Drug-Resistant (Pre-XDR), Or Treatment Intolerant/Non-responsive Multidrug-Resistant (MDRTI/NR) Pulmonary Tuberculosis in India PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Existing problem with DR TB management: Injectable regimens for longer duration with toxicity Poor adherence, treatment failures, continued transmission Need of the study: Oral regimens of shorter duration Improved treatment adherence Implementation of community-based models of care Reduction in direct costs and indirect costs of patients Improved treatment outcomes Need for shorter, tolerable and effective regimen Hence modified BPaL regimen is designed to study the newer shorter oral in varying doses of Linezolid for pre XDR Tb patients and MDR TI/NR patients |
C PADMAPRIYADARSINI; | 2021-10-07 |
| 241 | Strengthening of Airborne Preventive Measures Inside Households of Pulmonary TB Cases As A Tool to Reduce New Infections in Close Contacts. A Pilot, Controlled, Pre-post Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is currently one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent (ranking above HIV/AIDS). The investigators hypothesize that reducing respiratory exposure within the household, during the first weeks of TB treatment initiation of the index case, can reduce new TB infections in close contacts. For this purpose, a pilot, controlled, pre-post study will be set up, to evaluate the feasibility of implementing a bundle of respiratory precautions to all household contacts of new pulmonary TB cases, compared to standard of care, … |
MARÍA ELVIRA BALCELLS; | 2021-10-04 |
| 242 | Improved Diagnostics for Paediatric Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Research Question: To test the feasibility of TiKa system to reliably detect Mycobacterium tuberculosis in faeces of paediatric patients with Tuberculosis Study Design: … |
ST GEORGE’S UNIVERSITY OF LONDON | 2021-10-04 |
| 243 | The Effect of Lactoferrin in High Calorie Formula on IL-6 and IL10 in Children With Failure to Thrive and Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Lactoferrin is an iron-binding glycoprotein of the transferrin family which is expressed and refers to it as a red protein from milk. It is known that lactoferrin can modulate the overall immune response in inflammatory disorders including modulation of cytokine/ chemokine production and immune regulation that resenting by interleukin (IL)-10. Children with failure to thrive have increase the risk of infectious disease. The mechanism behind this may be due to impaired of immune function, in which pro-inflammation response is increased (IL-1β, IL-6), … |
ANDY DARMA; | 2021-10-04 |
| 244 | High Calorie Formula Intervention on Weight, Length, Total Lymphocyte Count, TNF-α and IGF-1 in Growth Faltering Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: High calorie formula (Oral Nutrition Supplement/ONS) are products used for oral nutrition support with the aim to increase the nutritional intake. they are a nutrition treatment option children with limited intake. ONS are typically used in addition to a normal diet, when diet alone is insufficient to meet daily nutritional requirement due to infection or others. ONS should be treated like medication, ensure they are labelled with the patient’s name and provided at the prescribed time. It is well established that nutritional deficiency or inadequate can impair immune function. Growing evidence suggest that for certain conditions, … |
ANDY DARMA; | 2021-10-04 |
| 245 | Research and Development of An Artificial Intelligence Technology System for Digital Pathological Diagnosis and Therapeutic Effect Prediction Based on Multimodal Data Fusion of Common Tumors and Major Infectious Diseases in The Respiratory System Using Deep Learning Technology PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To improve accurate diagnosis and treatment of common malignant tumors and major infectious diseases in the respiratory system, we aim to establish a large medical database that includes standardized and structured clinical diagnosis and treatment information such as electronic medical records, image features, pathological features, and multi-omics information, and to develop a multi-modal data fusion-based technology system for individualized intelligent pathological diagnosis and therapeutic effect prediction using artificial intelligence technology. |
YANG JIN; | 2021-10-01 |
| 246 | Multi-centric Prospective Cohort Study of TB Recurrence Free Cure Among Microbiologically Confirmed New Pulmonary Tuberculosis Patients Treated Under NTEP With The 4-month Moxifloxacin Containing Daily Regimen PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The 4-month daily regimen containing moxifloxacin (2HRZEM 7 / 2HRM7) of ICMR-NIRT was studied in 321 sputum positive pulmonary TB patients in a randomised clinical trial. Of the 321, there were 96% with sputum smear grading of 2+/3+ and 80% with >2 zone involvement in the chest radiograph, The sputum culture conversion at the end of intensive phase was 94%, … |
BANU REKHA; | 2021-10-01 |
| 247 | Inpatient Package to Reduce HIV and AIDS-related Death in Zambia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Early post-discharge mortality is high among HIV-infected Zambians admitted to the hospital. Likely this is in part due to missed opportunities to identify lethal coinfections and optimize HIV care during admission (and before discharge). In this study the investigators will develop and pilot a new approach to inpatient HIV care that follows international guidelines for management of advanced HIV disease. |
MICHAEL VINIKOOR; | 2021-10-01 |
| 248 | Global IBD Visualization of Epidemiology Studies (GIVES) in The 21st Century (GIVES-21) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Crohn’s disease (CD) and Ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) of unknown etiology. The pathophysiology of IBD relates to the mucosal immune response to antigenic stimulation from the gut microbiota secondary to environmental influence, on a background of genetic susceptibility. IBD represents an important public health problem because it affects mostly young people at an age when they are most active in their private and professional life, … |
SIEW CHIEN NG; | 2021-10-01 |
| 249 | Acquisition and Persistence of Rifampicin Resistance in Staphylococcus Aureus During and After Treatment for Latent Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Two commonly used treatments for latent tuberculosis infection are either 4 months rifampicin or 6-9 months isoniazid. The invistigators will study the risk of acquisition of rifampicin resistance in commensal Staphylococcus aureus in persons treated with rifampicin versus in persons treated with isoniazide. Through repeated swab cultures before, during, and after treatment the investigators will also investigate potential accumulation of mutations associated with rifampicin resistance over time. Finally, household contacts to persons with rifampicin-resistant S. aureus will be examined to investigate whether onward transmission of rifampicin-resistant S. aureus occurs within households. |
ANTON REEPALU; | 2021-09-30 |
| 250 | A Randomized Controlled Pilot Trial of Cyclosporine Vs Steroids in DRESS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Current treatments for patients with drug reaction with eosinophilia and systemic symptoms (DRESS) include supportive care, steroids and cyclosporine. No randomized controlled trial (RCT) exists in comparing these treatments and all available literature comes in the form of case reports and case series. These two treatments are considered standard of care and this trial seeks only to compare outcomes of DRESS between these two therapies. No additional labs, … |
SCOTT WORSWICK; | 2021-09-27 |
| 251 | Asthma Education and Its Impact on Emergency Department Visits By Asthmatic Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to evaluate the effects of an educational asthma program on the frequency of emergency department visits and identifying factors associated with frequent emergency department visits by asthmatic children and determine its effect on asthma severity and quality of life among asthmatic children and their caregivers. |
AIN SHAMS UNIVERSITY | 2021-09-26 |
| 252 | Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this pragmatic trial is to determine the effectiveness of a Whole Genome Sequencing (WGS) Drug Sensitivity Testing (DST) strategy to guide individualised treatment of rifampicin resistant tuberculosis (RR-TB) patients. The primary objective is to determine the effectiveness of this WGS DST strategy in patients diagnosed with RR-TB. We will additionally perform an exploratory health economics evaluation of both arms, and will determine the feasibility of the WGS DST strategy. |
ANNELIES VAN RIE; | 2021-09-21 |
| 253 | An Open-Label Phase 2 Trial to Evaluate The Male Reproductive Safety of A 6-Month Combination Treatment for Pulmonary Tuberculosis (TB) of Bedaquiline Plus Pretomanid Plus Moxifloxacin Plus Pyrazinamide (BPaMZ) in Adult Male Participants With Drug Resistant Pulmonary TB PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pretomanid is being used in an antimicrobial combination regimen(s) to treat patients with pulmonary tuberculosis (TB). The primary purpose of the Male Reproductive Safety – BPaMZ/SEM- clinical study is to evaluate the potential effect of pretomanid on human testicular function whilst being used in a 26 weeks antimicrobial combination regimen consisting of bedaquiline (B) plus pretomanid (Pa) plus moxifloxacin (M) and pyrazinamide (Z) (BPaMZ). |
GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT | 2021-09-16 |
| 254 | Análisis De La Precisión De Ensayos De Laboratorio Para Diagnóstico De Strongyloidiasis Humana En Escolares De Escuelas De Áreas Endémicas En Parroquias Del Cantón San Lorenzo, Provincia De Esmeraldas, Ecuador PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: the World Health Organization (WHO) has recently committed to promote the control of strongyloidiasis within 2030 targets for STH control programmes. A specific target is to establish by 2030 an efficient strongyloidiasis control programme in school aged children (SAC), envisaging ivermectin preventive chemotherapy (PC) of SAC at risk of morbidity due to strongyloidiasis. The monitoring of such ambitious PC activity strictly requires appropriate diagnostic tools, but fundamental gaps exist in this field. Indeed, … |
DORA BUONFRATE; | 2021-09-06 |
| 255 | MiRNA in Sweat, A Novel Digital Biomarker for Detection of Active Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The detection of miRNA (non-coding ribonucleic acid) in the blood in the context of active tuberculosis is an innovative approach to the detection of new disease-specific biomarkers. The primary goal of this analysis is to define, for the first time, an miRNA fingerprint for tuberculosis in sweat. Samples that were collected as part of the Sweatb Study (NCT03667742) project are examined for the occurrence of disease-specific, non-coding miRNAs to define new biomarkers in the sweat. These biomarkers can be detected non-invasively and will help in the detection of patients with active tuberculosis. |
JENS ECKSTEIN; | 2021-09-06 |
| 256 | Diagnostic Performance of A Novel Lipoarabinomannan Test (FujiLAM) to Detect Tuberculosis in HIV-positive Patients in Kenya PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The Fujifilm SILVAMP TB LAM (FujiLAM; Fujifilm, Tokyo, Japan) is a novel (not commercialized) urine based point-of-care assay to diagnose TB in HIV-positive patients. A first study using urine frozen samples has reported a higher sensitivity of this test over the currently commercialised Alere Determine TB LAM Ag assay (AlereLAM). |
MÉDECINS SANS FRONTIÈRES KENYA | 2021-09-01 |
| 257 | Vitamin D3 Supplementation Vs Placebo for Vitamin D Deficient/Insufficient Patients Undergoing Arthroscopic Rotator Cuff Repair: A Quadruple-blinded Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rotator cuff injuries are the most common cause of shoulder disability and is increasingly more prevalent in the aging population. Rotator cuff repair has long been the mainstay of treatment for symptomatic full-thickness tears and medium to large partial thickness tears that do no improve with nonoperative therapies. Approximately 32% of the US population is Vitamin D deficient. This is important for many health reasons, but specifically, Vitamin D has been found to play a critical role in bone mineralization and fracture healing/prevention. There is emerging data to support Vitamin D’s role in regulating the inflammatory response throughout the body, … |
MICHAEL BOGARD; | 2021-09-01 |
| 258 | Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the pharmacokinetic (PK) properties of antiretroviral (ARV) and anti-tuberculosis (TB) drugs administered during pregnancy and postpartum. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2021-09-01 |
| 259 | Immune Maping of Tuberculosis and Sarcoidosis Granuloma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here we compared the immunological micro-environments of granulomas from TB and sarcoidosis patients using in situ sequencing (ISS) transcriptomic analysis and multiplexed immunolabelling of tissue sections. |
MARTIN ROTTENBERG; | 2021-09-01 |
| 260 | Evaluation of Less Invasive Procedures for Visceral Leishmaniasis Treatment Efficacy Monitoring Test of Cure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Left untreated, visceral leishmaniasis (VL) is fatal. The highest burden of VL worldwide is in eastern Africa where field-adapted diagnostic and test-of-cure tools and treatment are lacking. The current laboratory tool to help assessing cure, treatment failure and relapse is microscopy, based on invasive sampling (e.g. splenic or bone marrow aspirate). Non-invasive, more sensitive tools will enable these assessments with minimum risk and discomfort to patients. This study aims to evaluate immunological and molecular tests to predict cure and relapse, … |
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS SWITZERLAND | 2021-09-01 |
| 261 | Bacillus Calmette-Guerin Against Covid-19 for Prevention and Amelioration of Severity Trial Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the efficacy of Bacille Calmette-Guérin (BCG) vaccination compared to placebo in reducing severe Covid-19 disease among elderly residents of skilled nursing facilities. The investigators hypothesize that BCG vaccination can reduce severity of Covid-19 disease. Patients who are residents of participating long-term care facilities (LTCFs), with the ability to understand and cooperate with study procedures, who agree to participate in the study will be randomly assigned to receive BCG vaccination or a placebo. Participants will be followed for up to twelve months to assess severity of Covid-19 outcomes. |
MEGAN MURRAY; | 2021-09-01 |
| 262 | The 8-week, Prospective, Randomized Controlled of IntraDermal Administration of Comirnaty® 6 Microgram Versus Intramuscular Comirnaty® 30 Microgram By 28 Days Interval Efficacy Study in Healthy Volunteer Related Papers Related Patents Related Grants Related Experts View Highlight: The 8-week, Prospective, Randomized controlled of IntraDermal administration of Comirnaty® 6 microgram compare to Intramuscular Comirnaty® 30 microgram by 28 days interval Efficacy Study in 4 groups of healthy volunteer ( 1 people who complete sinovac vaccination 2 people who received 1 dosage of AstraZeneca vaccine 3 naive vaccination 4 any other vaccination not in 1-3 with anti Spike antibody less than 650 AU/ ml) . Comparison of antibody level and T cell response to SAR-CoV-2 antigen in vitro after 28 day post vaccination is primary outcome and the side effect as well as infection rate in 8 weeks is secondary outcomes. |
SUBSAI KONGSAENGDAO; | 2021-08-31 |
| 263 | A Prospective, Randomized Open-Label Phase II Study of The Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People With TB and Co-infected With HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The METHOD study will examine whether adding metformin to standard antibiotic treatment for tuberculosis (TB) in people with HIV is safe and well tolerated. The study will also test if adding metformin clears the infection more quickly and with less lung damage. When enrolled, participants will have an equal chance of being in the group that takes standard TB medicines alone or in the group that also takes metformin. Participants will have a chance to be put on either: 1) standard TB medicines (isoniazid, rifampicin, ethambutol and pyrazinamide for two months, continuing isoniazid and rifampin for four more months) only; … |
HARDY KORNFELD; | 2021-08-26 |
| 264 | Exploring The Role of Microbiome in Susceptibility, Treatment Response and Outcome Among Tuberculosis Patients; A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a deadly infectious disease and major global public health problem. Recent evidence from animal studies suggests that the microbiome plays a role in TB pathogenesis and immune response. However, until now, no similar study has been performed in humans and thus any influence of the microbiota on TB or vice versa remains unknown. |
MUHAMMAD SHAHZAD; | 2021-08-22 |
| 265 | An Open-label, Sequential Non-randomised Pharmacokinetics Study of DTG Plasma Exposure When Given As Twice or Once Daily DTG in The Presence of Rifampicin in Children With HIV and TB Between 20-35kgs in SA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stage 1 proposed study will provide evidence to support the use of twice-daily dose 50mg DTG in children (20-35kgs) co-treated with RIF. |
MOHERNDRAN ARCHARY; | 2021-08-19 |
| 266 | Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The New Strat-TB trial is a superiority Phase III randomised control clinical trial with a 2X2 factorial design. The main aim of the study is to assess the efficacy and safety of high dose rifampicin and levofloxacin for 14 days in addition to standard TB therapy with or without steroids among adults hospitalized with HIV-associated disseminated tuberculosis. The investigators hypothesize that intensified treatment with increased rifampicin doses at 35 mg/kg plus levofloxacin will more rapidly reduce the mycobacterial load. The investigators also hypothesize that steroids will have an immune-modulatory effect and dampen the activation of the innate immune system. The investigators hypothesize that these two strategies will lead to improved survival in patients hospitalized with HIV-associated disseminated tuberculosis. |
CHARLOTTE SCHUTZ; | 2021-08-11 |
| 267 | Impact of Malnutrition on Pharmacokinetic or Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in TB-HIV Co-infected Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: TB-Speed TB-PK is a cross-sectional PK study of anti-TB treatment nested in the TB-Speed HIV and TB-Speed SAM studies aiming at assessing the impact of malnutrition on PK of rifampicin, isoniazid, pyrazinamide, and ethambutol in TB-HIV co-infected children in Uganda and Zambia. |
ERIC WOBUDEYA; | 2021-08-01 |
| 268 | Prospective Quality Improvement Project for High-Risk Diabetes Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes is the most important comorbidity of tuberculosis patients in Taiwan, and 1/4 of tuberculosis patients also It is a diabetic patient, and the treatment of latent tuberculosis infection is currently an important policy of the Taiwan Disease Control Agency One, because babies are prone to encounter difficulties in the early stages, because of the spread of Australian patients in the community, The Department of Disease Control encourages patients with diabetes to receive screening and treatment for latent tuberculosis infection. |
TAIPEI MEDICAL UNIVERSITY WANFANG HOSPITAL | 2021-07-29 |
| 269 | PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Infection in Liberia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Tuberculosis (TB) is a health threat for people living with human immunodeficiency virus (HIV). People living with HIV are more likely than others to develop active TB. Also, … |
STEPHEN A MIGUELES; | 2021-07-27 |
| 270 | Tuberculosis En Niños: Implementación De Una Estrategia De Cuidado Integral Para Los Niños Contacto De Pacientes Con Tuberculosis Pulmonar Bacilífera PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: childhood tuberculosis continues to be a major public health problem, despite the fact that the visibility of the epidemic in this population group has increased, studies are still lacking that can resolve the gaps that persist. Objective: To design, implement and evaluate an integrated care strategy for children under five years old household contacts of patients with smear positive pulmonary tuberculosis in Medellín and the Metropolitan Area. Methodology: quasi-experimental study, in which around 300 children household contacts of patients with smear positive pulmonary tuberculosis from Medellín and the Metropolitan Area will be evaluated, … |
CORPORACION PARA INVESTIGACIONES BIOLOGICAS | 2021-07-26 |
| 271 | TuBerculosis Incidence in AS, PsA or Pso Patients Treated With Secukinumab: Real World Evidence in Brazilian Environment (ToBeReal) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a retrospective observational study that relied on data extracted from patient’s chart review at the participating centers. Data was entered into an electronic Case Report Form (eCRF) designed to capture all relevant information to achieve the study objectives. After the ethical approval for each participating site, the respective Investigator and/or designated qualified study staff were responsible for including all eligible patients in a consecutive manner and entering their information into the eCRF. Patients were primarily identified with ankylosing spondylitis (AS), psoriatic arthritis (PsA), and psoriasis (PsO) diagnosis according to the International Classification of Diseases (ICD)-10 code (M45, M07, … |
NOVARTIS PHARMACEUTICALS | 2021-07-23 |
| 272 | Prokinetic Effect of Selected Nutraceuticals on Management of Gastrointestinal Disturbances Among Pulmonary Tuberculosis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Anti-Tuberculosis Treatment (ATT) is one of the effective treatments of tuberculosis but the use of drugs for a long time put an adverse effect on the gut and other organs of the body. Nutraceuticals are the cheapest natural sources with therapeutic effects. These natural medicines help in alleviating gastrointestinal disturbances. This study will be conducted to overcome gastrointestinal issues with the help of nutraceuticals, which are more acceptable by the majority and have no side effects. |
ASMA LATIF; | 2021-07-15 |
| 273 | Randomized, Blinded, Single-arm Intradermal Injection, Control of Similar Products on The Market, The Safety Pre-evaluation Phase I Clinical Trial of BCG-PPD in Tuberculosis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A total of 80 TB patients aged 65 years and below who are randomly assigned to the experimental group and the control group. The experimental group is injected with BCG-PPD test drug once, and the control group is injected with BCG-PPD control drug once.Subjects undergoing physical examination, vital signs, blood routine, urine routine, blood biochemistry, electrocardiogram, chest X-ray, tuberculosis culture, tuberculosis smear, HIV antibody test and blood pregnancy（only women of childbearing age） during the screening period.Vital signs were checked before skin test, the injection site is photographed at 0min after skin test, … |
ZHONGYUAN WANG; | 2021-07-02 |
| 274 | Integrating Electronic Patient Reported Biometric Measures (ePReBMs) From ADAMM-RSM in Respiratory Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Lung diseases are one of the most common causes of emergency room visits. There are very few tools that are able to predict which patients will have a worsening or increasing severity of their condition. There are also limited ways to check the health of patients with respiratory conditions at home and during the time between medical appointments. The ADAMM-RSMTM device records heart rate, breathing rate, temperature, … |
GIOVANNI FERRARA; | 2021-07-01 |
| 275 | Relation Between Plasma Soluble Urokinase Plasminogen Activator Receptor and Behçet’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine whether plasma levels of the soluble urokinase plasminogen activator(suPAR) can serve as a blood-based biomarker for diagnosis of Behçet’s disease and its correlation with disease activity. |
MOHAMED FARGHALY RAMADAN; | 2021-07-01 |
| 276 | A Randomized Controlled Trial to Test A Novel Negative Pressure Isolation Device During Aerosol Generating Procedures in The Operating Room PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test the safety and efficacy of a new isolation device to contain aerosol during aerosol-generating procedures in the operating room. |
JOHN SHIN; | 2021-06-29 |
| 277 | Incidence of Metabolic Syndrome in People Living With HIV Without ExperienCe to ART Who Start DoLutegravir Based-Regimen Compared With BictegrAvir Based-RegimeN After 48 Weeks (MICTLAN Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to identify the incidence of MetS at 48 weeks for ATP III score in patients living with HIV (PLH) who started antiretroviral therapy (ART) with Dolutegravir based-regimen compared with Bictegravir based-regimen. MICTLAN is a randomized open clinical trial developed with men PLH who started ART randomized to BIC/FTC/TAF or DTG/3TC/ABC. Weight, height, blood pressure, and waist circumference and electriccircumference were measured during routine clinical care; in addition, electric bioimpedance were measured atmeasuredwas done; repeated measures of weight in kilograms were done at baseline, … |
JOSÉ ANTONIO MATA MARÍN; | 2021-06-25 |
| 278 | Effect of SARS-CoV-2 Disease on Immune Responses, Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the Coronavirus disease (COVID-19). Tuberculosis (TB) is the foremost cause of infectious deaths globally. In 2025, an additional 1.4 million TB deaths could occur as direct consequence of the COVID-19 pandemic. It is postulated that individuals with latent or active TB are more susceptible to SARS-CoV-2 disease and that COVID-19 disease rate is high in patients with active TB, … |
S. SUBASH BABU; | 2021-06-21 |
| 279 | Effectiveness of Road Traffic Crashes First-aid Education on Knowledge, Attitude, and Practice Among Commercial Motorcyclists in Kigali-City, Rwanda PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Prehospital management after road traffic crashes(RTC) is a predicting factor to patient outcomes especially in Low-Income Countries where emergency medical services are lacking. This may explain the high mortality related to RTC in Rwanda for instance, where the delay to reach the hospital of these victims was found as an independent factor to death . For that reason, this study hypothesizes that the training of non -professionals as commercial motorcyclists could help to reduce trauma-related mortality and morbidity in Rwanda. The protocol general objective is to evaluate the effectiveness of road traffic crashes first -aid education on knowledge, attitudes, … |
CHRISTINE UFASHINGABIRE MINANI; | 2021-06-19 |
| 280 | A Phase IIc Trial of Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare a 3-month rifapentine (RPT)/clofazimine (CFZ)-containing regimen with CFZ loading dose versus 6-month standard of care (SOC) for drug-susceptible (DS) tuberculosis (TB). |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2021-06-16 |
| 281 | Impact of Second Forward View Examination of The Proximal Colon on Adenoma Detection Rate PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the impact of second forward view examination of the proximal colon on adenoma detection rate Inclusion criteria：Patients ≥18 years of age undergoing screening, follow-up monitoring, and diagnostic colonoscopy Exclusion criteria：①Cecal intubation failed. ②Have a history of colorectal surgery. ③Insufficient bowel preparation, inadequate bowel preparation quality (Boston Bowel Preparation Scale (BBPS)scores < 2 in any segment of the colon). ④Inflammatory bowel disease or intestinal tuberculosis. ⑤Familial polyp syndrome. ⑥polyp retrieval failure. ⑦Patients with coagulation dysfunction. Patients ≥ 18 years of age who came to our hospital's Digestive Endoscopy Center for screening, ... |
ZHU XIAOJIA; | 2021-06-14 |
| 282 | Improving Timeliness of Birth Dose Vaccines in 15 Health Facilities in Cameroon Through Integrating Immunizations Into Maternity and Newborn Care Services: A Feasibility Assessment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This feasibility assessment is to provide quantitative findings of an intervention integrating immunizations into maternity and newborn care across 15 health facilities in Cameroon. |
ANKOUANE ANDOULO FIRMIN; | 2021-06-10 |
| 283 | A Qualitative Study to Optimize A Community-Based Pediatric TB/HIV Prevention Intervention and Implementation Strategy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This qualitative study is designed to elicit the perspectives of relevant stakeholders to adapt a community-based TB/HIV intervention aimed on providing home-based TB prevention treatment (TPT) initiation for child TB contacts, to design its implementation strategy and, post intervention, to assess lessons learned for future scale up. Participants will include policy makers and health system managers, nurse and physician providers, community health team members, and child caregivers of TB-exposed children. Stakeholders will be asked to participate in two interviews, … |
NICOLE SALAZAR-AUSTIN; | 2021-06-04 |
| 284 | Evaluation of Advanced HIV Disease Differentiated Care Model in Malawi: A Mixed Methods Non-randomized Cluster Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the implementation of an enhanced package of care, CD4 and tuberculosis lipoarabinomannan (TB-LAM) tests and the initiation of patients on TB prophylaxis [TPT and CPT], on retention in care and viral suppression ((<50 copies/ml) at 6 and 12 months after AHD care and treatment enrollment. The study will also assess the change in AHD screening, management and service uptake indicators among PLHIV clients before and after implementation of the QI collaborative implementation (QICI) project, evaluate the acceptability and feasibility of the AHD package of care among patients and HCWs providing related health services, ... |
THULANI MAPHOSA; | 2021-06-01 |
| 285 | WHO Public Health Emergency Solidarity Clinical Trial for COVID-19 Treatments PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In early 2020 there were no approved anti-viral treatments for COVID19 Infection. The SOLIDARITY trial is a multicentre adaptive international randomised trial sponsored by Word Health Organization to determine the efficacy of Remdesivir (daily infusion for 10 days), or Acalabrutinib (orally twice daily for 10 days), or Interferon β1a(daily injection for 6 days) compared with local standard of care in patients admitted to hospital for COVID19 infection on all-cause mortality, stratified by severity of disease at the time of randomisation. The major secondary outcomes are duration of hospital stay and time to first receiving ventilation (or intensive care). |
MARVIN REID; | 2021-06-01 |
| 286 | A Trial of Vitamin D Supplementation Among Tuberculosis Patients in South India PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to understand the effects of vitamin D supplementation on immunological outcomes among patients with tuberculosis. |
SAURABH MEHTA; | 2021-06-01 |
| 287 | Low-dose CT Compared to Lung Ultrasonography Vs Standard of Care for The Diagnosis of Pneumonia in The Elderly: A Multicentre Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Pneumonia is a leading cause of mortality and a common indication for antibiotic in elderly patients. However, its diagnosis is often inaccurate. We aim to compare the diagnostic accuracy, the clinical and cost outcomes and the use of antibiotics associated with three imaging strategies in patients >65 years old with suspected pneumonia in the emergency room (ER): Chest-X ray (CXR, standard of care), … |
VIRGINIE PRENDKI; | 2021-06-01 |
| 288 | The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired health-related quality of life. As a chronic disease, rheumatoid Chronic arthritis needs long-term treatment. At the same time, RA can cause skin, eye, lung, liver, kidney, blood and cardiovascular diseases All of them were extraarticular lesions. It causes a heavy burden to the patients themselves, their families and the society. The main clinical manifestations of RA were morning stiffness Joint swelling and pain, cartilage destruction and joint space narrowing, if not treated, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2021-05-31 |
| 289 | The Role of The Bacillus Calmette-Guérin Vaccine (BCG) in The Clinical Evolution of COVID-19 and in The Efficacy of Anti-SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) Vaccines PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinical trial with randomized allocation in two arms (BCG vaccine versus placebo) of volunteers at risk but not yet infected nor vaccinated against SARS-CoV-2. Initially will be evaluated whether BCG has a protective role against severe form of the disease. After participants are vaccinated against COVID-19, it will be evaluated whether BCG favors the vaccine’s efficacy. Volunteers will be recruited in three Brazilian states, with at least 250 seronegative in each group. The BCG-trained immunity stimulus will be investigated by assessing cytokines at D0 and D60 in a subsample of 50 participants per group. Until being vaccinated against COVID-19, … |
SIMONE LADEIA-ANDRADE; | 2021-05-27 |
| 290 | Management of Osteoarticular Infection Due to Multidrug Resistant Mycobacterium Tuberculosis Strains in France PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The recommendations for the treatment of MDR tuberculosis are based on pulmonary tuberculosis since there is a lack of specific recommendations for TB bone and osteoarticular disease, including those due to multi drug resistance strains (MDR IOATB). Given the lack of data regarding MDR IOATB, it may be helpful to study the diagnosis, medical treatment, surgical indications and prognosis of a cohort of MDR IOATB patients. |
ALEXANDRA AUBRY; | 2021-05-17 |
| 291 | The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in The Treatment of Periodontal Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Periodontal disease is an infectious pathology that consists of the destruction of the gums and supporting structures around the teeth. There are several mechanisms involved in this process. In healthy conditions there is a balance between the bacteria present in the gums and the defence mechanisms of the host to fight the disease. One of the substances involved in favouring this protective mechanism is a peptide called LL-37. The aim of this study is to find out more about the rol of this peptide during this process by using a non invasive method of analysis consisting of analysing some samples of the fluid existing between the gums and the teeth. This clinical study will take place at the University Clinic at the University Rey Juan Carlos, Alcorcon (Madrid), Spain. Patients that attend the clinic suffering from gum disease will be offered the possibility to participate in this study. A full questionnaire indicating the risks and benefits of participating in the study as well as the management of confidential personal data will be discussed with the participants in full detail. Full consent will be sought before commencing the study. Firstly, all participants will receive a through periodontal (gum) examination to assess if they suffer from periodontal disease and to what extent (severity). Based on this preliminary data, patients will be classified in different categories. Patients will be divided in two groups: – 30 Healthy patients (no signs of periodontitis) – 30 Periodontal patients (subdivided in 2 groups of 30, depending of the severity of their disease: – 15 patients with Stage I-II periodontitis (mild/moderate) – 15 patients with Stage III-IV periodontitis (severe). The intervention will consist on taking samples of crevicular fluid (the fluid found in the space between the gum and the root of the tooth) to quantify the presence of LL-37 as well as IL-4, IL-6, IL-10, which seems to be associated with the defence mechanisms (immunity) of the host against periodontal disease. These samples will be analysed in the laboratory by using some specific procedure called ELISA. All patients from the test group will receive a basic course of periodontal treatment (root scale and polish), which is intended to remove the bacteria causing the disease from the space between the gums and the roots (periodontal pocket). Samples of crevicular fluid will be obtained before commencing the treatment. After 4-6 weeks, a new periodontal examination will take place to assess if there is an improvement of the condition and also to quantify the levels of LL-37, IL-4, IL-6, IL-10. The findings of this study will help to understand the role of this peptide in the defence mechanism of the host against periodontal disease. This could ultimately serve to develop new therapies that could include the use of this peptide in addition to the routine periodontal treatment prescribed to improve the healing conditions of the patient against periodontal disease. |
DAVID MADRUGA-GONZALEZ; | 2021-05-17 |
| 292 | Two-site Laboratory-based Diagnostic Accuracy and Feasibility Study of The Xpert MTB/XDR Assay for Detection of Isoniazid, Fluoroquinolone, Ethionamide and Second-line Injectable Anti-tuberculosis Drug Resistance PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The Cepheid Xpert MTB/XDR cartridge, which runs on the same platform as Xpert MTB/RIF Ultra, has been developed to detect additional resistance to isoniazid, fluoroquinolones and second-line injectable anti-tuberculosis drugs and provides results within 2 hours and on primary samples. An evaluation of the the Xpert MTB/XDR assay is currently underway in clinical settings in South Africa, India and Moldova. The TB-CAPT MTB/XDR Study will add further diagnostic accuracy and feasibility data to the evidence base for the Xpert MTB/XDR assay. |
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS SWITZERLAND | 2021-05-14 |
| 293 | A Phase IIB, Open-Label, Randomized Controlled Dose Ranging Multi-Center Trial to Evaluate The Safety, Tolerability, Pharmacokinetics and Exposure-Response Relationship of Different Doses of Sutezolid in Combination With Bedaquiline, Delamanid and Moxifloxacin in Adult Subjects With Newly Diagnosed, Uncomplicated, Smear-Positive, Drug-sensitive Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an open-label, randomized, controlled, multi-center Phase IIB dose-finding trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response-relationship of different doses of sutezolid (STZ) in combination with bedaquiline, delamanid and moxifloxacin in adults with newly diagnosed, uncomplicated, smear positive and drug sensitive pulmonary tuberculosis. Participants will be randomized to one of five arms containing bedaquiline, delamanid and moxifloxacin with different doses of STZ (0mg, 600mg once daily (OD), 1200mg OD, 600 mg twice daily (BD), 800 mg BD). Study treatment duration will be three months, … |
MICHAEL HOELSCHER; | 2021-05-06 |
| 294 | Evaluation of The Efficacy and Safety of A Short-course, Daily, 4-month Regimen Including Isoniazid, Pyrazinamide, Rifapentine and Moxifloxacin (2HZPM/2HPM) for The Treatment of Drug-susceptible Pulmonary Tuberculosis in Taiwan (ESCAPE-TB) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The development of efficacious, safe, and shorter treatment regimens could significantly improve TB management and treatment success rates. This prospective, 3-year, single arm study is to evaluate the efficacy and safety of a short-course, 4-month regimen including isoniazid(H), pyrazinamide(P), rifapentine (P), and moxifloxacin(M) (2HZPM/2HPM) for the treatment of drug-susceptible, pulmonary tuberculosis, and compared with a historical control group receiving the standard six-month regimen. |
SUSAN SHIN-JUNG LEE; | 2021-05-01 |
| 295 | BCG Vaccination Scar Formation in Children Under Five Years :Factors Affecting Its Formation and Subsequent Adverse Effects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study of BCG Vaccination scars of under five years old children . Estimation of the frequency of children without BCG scar after BCG vaccine . Evaluation of factors which may affect scar formation . Tuberculin skin test response in children without BCG scar . Frequency of vaccine adverse effects as injection-site abscess, lymphadenitis, severe local reaction, and disseminated BCG infection. |
SHIMAA ABD ELHAMID MAHRAN; | 2021-05-01 |
| 296 | Immunology Dysregulation in Lymphadenitis Tuberculosis : An Observational Study Using Patient’ Block Paraffins 2019 Until 2021 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mycobacterium tuberculosis (M. tuberculosis) infection is still a problem that cannot be overcome in Indonesia. In 2018 the number of tuberculosis (TB) sufferers in Indonesia reached more than 850/100,000 population, an increase around 20% from the previous year’s incidence. One of the highest number of cases is in East Java Province, … |
BERNADETTE DIAN NOVITA; | 2021-05-01 |
| 297 | Comparison of Anti-tuberculous Drug Levels in Diabetic and Non-diabetic Tuberculosis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares blood levels of tuberculosis medications between diabetic patients and non-diabetic patients. There is some research that suggests these medications are at lower levels in diabetic patients with tuberculosis, … |
JESSICA BARRETT; | 2021-05-01 |
| 298 | Transmission of Tuberculosis Among Illicit Drug Use Linkages PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is the leading infectious disease killer globally and leading cause of death in persons with HIV. The most effective way to reduce TB incidence and mortality is to interrupt transmission. This requires finding and treating individuals with TB disease early, … |
KAREN JACOBSON; | 2021-04-22 |
| 299 | Predicting The Future: Incipient Tuberculosis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will study, prospectively, if contacts (household or close contacts) of tuberculosis (TB) patients with high C-reactive protein (CRP), low hemoglobin (Hb) levels, and a positive Xpert Host Response (HR) cartridge result develop active TB within 12 months. They will also investigate if there is a correlation between progressing to active TB within 12 months and having high levels of the iron homeostasis markers (Hepcidin, … |
GRANT THERON; | 2021-04-21 |
| 300 | Short Intervention and Measurement of Pharmacokinetics of Linezolid in Tuberculosis Meningitis: A Pharmacokinetics and Safety/Tolerability Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis meningitis (TBM) is the most severe manifestation of TB, resulting in death or neurological disability in up to 50% of affected patients, despite antibacterial treatment. This TBM treatment follows the model for pulmonary TB by using the same first-line TB drugs (a combination of rifampicin, isoniazid, pyrazinamide and ethambutol) and the same dosing guidelines, although it is known that penetration of two of these drugs (rifampicin and ethambutol) into cerebrospinal fluid (CSF) is limited. Improvement of treatment of TBM is urgently needed. To do so, … |
AHMAD RIZAL GANIEM; | 2021-04-21 |
| 301 | A Cross-Sectional Study to Estimate The Influence of Malnutrition, Diabetes Mellitus and Helminth Infections on Biosignatures in Latent Tuberculosis in A South Indian Population PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: About 2 billion people worldwide are infected with tuberculosis (TB). Ninety percent of those people have latent TB infection (LTBI). Risk factors like malnutrition, diabetes mellitus (DM), and helminth infection can affect the development of active TB. Researchers want to study LTBI individuals with these issues to see how they may contribute to a person s higher risk for developing active TB. This study will take place in Chennai, India. Objective: To estimate the prevalence of malnutrition, DM, … |
THOMAS B NUTMAN; | 2021-04-19 |
| 302 | Multicentre Clinical Trial to Assess The Performance of Culture-free, End-to-end Targeted NGS (tNGS) Solutions for Diagnosis of Drug Resistant TB (DR-TB) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Current rapid molecular assays for detection of drug-resistant TB from direct clinical samples have important limitations. They are not suited for high-throughput settings; can only be used to detect a limited number of target gene regions and are not ideal for detection of phenotypic resistance conferred by mutations across large gene regions (e.g. pyrazinamide). Culture-free, end-to-end targeted NGS (tNGS) Solutions for Diagnosis of Drug Resistant TB can offer higher throughput and greater accuracy across more TB drugs than current WHO endorsed molecular assays, … |
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS SWITZERLAND | 2021-04-16 |
| 303 | Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) Study PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: To reduce the burden of TB worldwide through more accurate, faster, simpler, and less expensive diagnosis of TB Every year, more than 3 million people with TB remain undiagnosed and 1 million die. Better diagnostics are essential to reducing the enormous burden of TB worldwide. The Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) brings together experts in TB care, technology assessment, diagnostics development, laboratory medicine, epidemiology, health economics and mathematical modeling with highly experienced clinical study sites in 10 countries. |
ADITHYA CATTAMANCHI; | 2021-04-14 |
| 304 | Creating A Sustainable Infrastructure for SARS-COV-2 (COVID-19) Testing at Syringe Exchange Programs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PWIDs have been an underserved population in the context of the current pandemic; thus, little is known about the prevalence of COVID-19 and the acceptability and possible reach of testing for COVID-19 among PWIDs. To address this gap, this study leverages a current partnership with HIV Alliance (HIVA) in Oregon and our Community and Scientific Advisory Board to support implementation and sustainability of a COVID-19 testing program. Specifically, we will use community-based participatory approaches to develop, implement, and evaluate a COVID-19 testing program offered through HIVA’s Syringe Services Programs (SSP), … |
UNIVERSITY OF OREGON | 2021-04-14 |
| 305 | Detection of SARS-CoV-2 RNA and Biomarkers in Coughed Droplets From Patients With COVID-19 and Controls PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn how to better detect infection and understand how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes lung disease and is spread. The novel device called PneumoniaCheck is a safe way to collect material from the lung from coughs. Study participants will collect cough specimens over a 24 hour period. |
LARRY J. ANDERSON; | 2021-04-14 |
| 306 | Repair of Nasal Septal Perforations Using (Autologous) Nasal Chondrocyte Tissue Engineered Cartilage (N-TEC)- A Phase I Clinical Trial Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the safety and feasibility of implanting an engineered cartilage tissue in an interposition graft with a temporoparietal fascia (TPF) flap to repair medium size septal perforation. The engineered cartilage graft is obtained by culturing expanded autologous nasal chondrocytes within a collagen type I/III membrane. In addition, first data on efficacy will be collected. |
MARTIN HAUG; | 2021-04-09 |
| 307 | Randomized Controlled Trial to Compare Clinical Efficacy of Surgical and Filtering Facepiece 2 Masks for Care Home Workers Treating COVID-19 Patients PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Recent results demonstrated an increased risk of COVID-19 infection among healthcare workers (HCW), particularly when access to personal protective equipment (PPE) was inadequate. (ref). During the COVID-19 pandemic, access to PPE has become complicated by a surge in worldwide demand combined with production limitations and logistical barriers. Since their introduction in hospitals in the 1990s, filtering facepiece (FFP) masks, mostly of the FFP2 type, are used by HCWs to protect themselves against bioaerosols due to tuberculosis, measles, … |
UNIVERSITY OF ZURICH | 2021-04-08 |
| 308 | Pilot Study for Development of Microneedles for Diagnosis of Latent Tuberculosis Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate new technique, microneedle, to detect latent tuberculosis (TB) in healthy volunteers |
SIVAPORN GATECHOMPOL; | 2021-04-08 |
| 309 | Cardiopulmonary Function and Quality of Life in People With Sequelae of Pulmonary Tuberculosis Undergoing Pulmonary Rehabilitation: Controlled and Randomized Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This work aims to assess cardiopulmonary function and quality of life in people with sequelae of pulmonary tuberculosis undergoing rehabilitation. It is an experimental clinical study, with evaluation before and after the intervention. Included participants will be randomized and divided into a control group and an intervention group. Quality of life is examined by two questionnaires and physical fitness by specific tests, before and after the intervention. The intervention is the realization of a supervised physical exercise protocol. |
DIEGO DE FARIA MAGALHÃES TORRES; | 2021-04-07 |
| 310 | A Phase 3 Study of The Efficacy, Safety, and Pharmacokinetics of Ustekinumab As Open-label Intravenous Induction Treatment Followed By Randomized Double-blind Subcutaneous Ustekinumab Maintenance in Pediatric Participants With Moderately to Severely Active Crohn’s Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of ustekinumab dosing in inducing clinical remission (Global) and in maintaining clinical remission (US); to evaluate the safety profile and ustekinumab exposure (pharmacokinetics \[PK\]) in pediatric participants with moderately to severely active Crohn’s disease. |
JANSSEN RESEARCH & DEVELOPMENT | 2021-04-06 |
| 311 | A Multicenter, Open-Label, Randomized Study to Assess The Pharmacokinetics, Safety, and Efficacy of Two Doses of Bimekizumab in Adolescent Study Participants With Moderate to Severe Plaque Psoriasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess th pharmacokinetics (PK) of bimekizumab administered subcutaneously (sc) in adolescents with moderate to severe plaque psoriasis (PSO). |
UCB BIOPHARMA SRL | 2021-04-06 |
| 312 | Safety of Rifampicin at High Dose for The Treatment of Adult Subjects With Complex Drug Susceptible Pulmonary and Extrapulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety of rifampicin given at a dose three times as the standard one, in persons with tuberculosis that belong to groups that have not been widely included in previous trials. |
ADRIÁN SÁNCHEZ-MONTALVÁ; | 2021-04-01 |
| 313 | A Study of Ultrashort PRS Regimen V in The Treatment of MDR-TB PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an exploratory, prospective, randomized, active control, and open label clinical trial to evaluate the efficacy and safety of 6-9 months treatment with the ultrashort PRS Regimen V. |
WEI SHA MD & PHD; | 2021-04-01 |
| 314 | A Randomized Controlled Trial to Evaluate A Scalable Active Case Finding Intervention for TB Using A Point-of-care Molecular Tool (Gene Xpert) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: TB remains the foremost infectious disease killer globally. A startling statistic is that two out of every five TB cases globally (40%) remain undiagnosed and untreated. These ‘missed’ or undiagnosed cases are disproportionately concentrated in large peri-urban ‘slums’ and informal settlements of large cities in Africa and Asia (they are frequently minimally symptomatic but remain infectious). The lack of a sensitive low cost same-day test represented a major challenge to active community-based case finding (ACF) compared to the current model where patients ‘self-seek’ care (passive case finding). More recently, … |
KEERTAN DHEDA; | 2021-03-26 |
| 315 | Tuberculosis As A Risk Factor for A Severe Course and Adverse Long-term Outcome of A Symptomatic Sars-CoV-2 Infection in Johannesburg, South Africa PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study has two main objectives. First, the clinical characteristics and outcomes of hospitalized patients with symptomatic Covid-19 disease will be compared between persons with a history of past or current TB infection or disease and those, who have had no TB history. The possible impact of an HIV-coinfection will be also addressed in the planned investigations and analysis. Second, the long-term consequences and clinical outcomes of Covid-19 up to 12 months post-infection will be analysed in both groups (with and without TB history) with the main focus on cardio-pulmonary outcomes. |
ANDREA RACHOW; | 2021-03-23 |
| 316 | Prevalence of Intrathoracic Lymph Node Calcifications and Metastatic Involvement in Patients Undergoing Endosonography for Diagnosis And/or Mediastinal Staging of Intrathoracic Malignancy: A Cross-sectional Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The presence of calcifications, which is a relatively common feature in intrathoracic lymph nodes, typically contributes to confer them a heterogeneous aspect during endosonographic B-mode examination, but their prevalence and a possible association between calcifications and metastatic involvement has never been systematically evaluated. We hypothesize that, in patients undergoing mediastinal diagnosis or staging of suspected/known lung cancer/intrathoracic malignancies, the prevalence of lymph node metastases is similar in calcified and non-calcified lymph nodes. |
ROCCO TRISOLINI; | 2021-03-20 |
| 317 | A Phase 3 Study of The Efficacy, Safety and Pharmacokinetics of Ustekinumab As Open-label Intravenous Induction Treatment Followed By Randomized Double-blind Subcutaneous Ustekinumab Maintenance in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate: a) the efficacy of ustekinumab dosing in inducing clinical remission, b) safety profile of ustekinumab, and c) ustekinumab exposure (pharmacokinetics \[PK\]) in pediatric participants with moderately to severely active UC. |
JANSSEN RESEARCH & DEVELOPMENT | 2021-03-17 |
| 318 | Protecting Native Families From COVID-19 (PROTECT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to increase and hasten testing among those with COVID-19 symptoms and improve adherence to recommended strategies following positive test results in high-risk groups in the White Mountain Apache and Navajo Nation communities. |
ALLISON BARLOW; | 2021-03-08 |
| 319 | A Phase 2a Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Proof-of-Concept Clinical Study to Evaluate The Safety and Efficacy of JNJ-64304500 As Add-on Therapy to Standard of Care Biologic Therapy With Anti-Tumor Necrosis Factor Alpha or Anti-Interleukin 12/23 in Responder Not Remitter Participants With Active Crohn’s Disease Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy and safety of JNJ-64304500 as add-on therapy to standard of care (SOC) biologic treatment with anti-tumor necrosis factor alpha or anti-interleukin 12/23 inhibitors in participants with active Crohn’s disease in response but not remission to SOC biologic therapy. |
JANSSEN RESEARCH & DEVELOPMENT | 2021-03-03 |
| 320 | Novel Triple-dose Tuberculosis Retreatment Regimen: How to Overcome Resistance Without Creating More in Niger PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine if a high-dose first-line regimen is non-inferior (non-inferiority margin 10%) in terms of safety to the same regimen at regular dosing, in previously treated patients with rifampicin-susceptible recurrent Tuberculosis (TB). |
SANI KADRI; | 2021-03-01 |
| 321 | Role of MHealth-based Interventions Including Social Media to Improve Childhood Immunization Coverage During COVID 19 Pandemic in Pakistan: Qualitative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In order to improve routine immunization uptake during COVID-19 pandemic, and to understand the perceptions and barriers related to vaccine hesitancy and coverage during COVID 19 and to explore the need for COVID-19 vaccination, separately and as a part of routine immunization, the investigators will be using qualitative methodology to explore and understand the role of mHealth and social media interventions, that are most suitable in Pakistani context to improve vaccination coverage during COVID-19 pandemic. |
ABDUL MOMIN KAZI; | 2021-03-01 |
| 322 | Comparative Study of Outcome Between Primary Closure and Delayed Primary Closure of Skin Incision in Emergency Caesarean Section PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pregnant mothers requiring emergency cs with history of ruptured membranes would be allocated randomly into two groups in an aim to study the comparative outcome of different methods of skin closure namely primary and delayed primary closure on the incidence of wound infections requiring secondary closures and to detect the associated risk factors increasing chance of surgical site infections. |
JHUMA BISWAS; | 2021-03-01 |
| 323 | Evaluation of Early Bactericidal Activity and Safety in Pulmonary Tuberculosis With Pyrifazimine (TBI-166) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The new drug pyrifazimine (previous name: TBI-166) developed by the Institute of Materia Medica of the Chinese Academy of Medical Sciences which is Beijing Union Pharmaceutical Second Factory relied on is obtained by retaining the key skeleton of the lead drug clofazimine which can exert its efficacy and modification by introducing moderate polar groups structural. While the drug has strong activity against tuberculosis-sensitive bacteria and drug-resistant bacteria in vivo and in vitro, its pharmacokinetic properties and skin staining side effects have been significantly improved compared with the lead drugs, … |
CHU NAIHU; | 2021-03-01 |
| 324 | Comparing The Accessibility of The World Health Organization’s Tuberculosis Guidelines to The ETB Catalogue of Recommendations: A Two-Arm Superiority Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The World Health Organization’s Global Tuberculosis Programme (WHO-GTB) issues evidence-informed guideline recommendations on tuberculosis (TB). These recommendations are used by decision-makers, guideline developers and other stakeholders. In an effort to improve the accessibility and usability of these recommendations, a new eTB catalogue of recommendations has been developed. This study aims to compare the accessibility of the new eTB catalogue to the earlier method of accessing recommendations directed through the general WHO website. |
MICAYLA N MATTHEWS; | 2021-02-26 |
| 325 | Can BCG Vaccination at First Health-facility Contact Reduce Early Infant Mortality? A Cluster Randomised Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacillus Calmette-Guérin (BCG) vaccination is recommended at birth to protect against tuberculosis (TB) in countries with high TB burden. BCG is supplied in multidose vials with limited durability after reconstitution. In Guinea-Bissau, this has led to a practice of only opening a BCG vial at specific days, and only if sufficient children are present. Therefore, BCG vaccination is frequently delayed. Accumulating evidence indicates that BCG has beneficial effects on survival beyond the specific protection against tuberculosis, … |
ANE B FISKER; | 2021-02-25 |
| 326 | A Multicenter, Randomized, Placebo-controlled, Double-blind, Proof-of-concept Study of Guselkumab in Participants With Systemic Sclerosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the efficacy of guselkumab in participants with systemic sclerosis (SSc). |
JANSSEN PHARMACEUTICAL K K | 2021-02-24 |
| 327 | Making An Early Diagnosis of Talaromycosis – A Strategy to Reduce Morbidity and Mortality in Advanced HIV Disease in Southeast Asia PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a research study to determine whether a new antigen detection test called Mp1p EIA can make an early diagnosis of talaromycosis from the blood and urine of patients. Talaromycosis is a life-threatening infection caused by a fungus endemic in Southeast Asia commonly found in patients with advanced HIV disease called Talaromyces marneffei. |
THUY LE; | 2021-02-22 |
| 328 | Prospective, Multicentre Evaluation of The Accuracy of CAD4TB and C-reactive Protein Assay As Triage Tests for The Diagnosis of Pulmonary Tuberculosis in Presumptive Adult TB Patients (TB TRIAGE+ Accuracy) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In the TB TRIAGE+ ACCURACY study, the accuracy of the following products will be determined: – CAD4TB (Delft Imaging System, NL), a digital chest x-ray analysis software – Afinion CRP assay (Alere Afinion, USA), … |
KLAUS REITHER; | 2021-02-15 |
| 329 | Spectrum of Bacterial Infections in Rheumatology and The Role of Urinary Tract Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Retrospective study of patients with a proved non-tuberculous osteoarticular infection (OAI) diagnosed in a rheumatology department during the years 2010-2020. The objectives are : – To describe sites, type of micro-organism, clinical data, origin of infection, therapeutic modalities et outcome – To compare OAI of urinary origin with those with another origin |
EDOUARD PERTUISET; | 2021-02-12 |
| 330 | Intensified Tuberculosis Treatment to Reduce The Mortality of HIV-infected and Uninfected Patients With Tuberculosis Meningitis: A Phase III Randomized Controlled Trial (Acronym: INTENSE-TBM) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: INTENSE-TBM is randomized controlled, phase III, multicenter, 2 x 2 factorial plan superiority trial assessing the efficacity of two interventions to reduce mortality from tuberculous meningitis (TBM) in adolescents and adults with or without HIV-infection in sub-Saharan Africa: – Intensified TBM treatment with high-dose rifampicin and linezolid, compared to WHO standard TBM treatment. – Aspirin, compared to not receiving aspirin. The trial will be open-label for anti-TB treatment and placebo-controlled for aspirin treatment. |
FABRICE BONNET; | 2021-02-07 |
| 331 | Tuberculosis (TB) Aftermath: A Hybrid Type I Effectiveness-implementation Non-inferiority Randomized Trial in India Comparing Two Active Case Finding (ACF) Strategies Among Individuals Treated for TB and Their Household Contacts PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: TB Aftermath will compare effectiveness, cost-effectiveness and feasibility of two ACF strategies for detecting recurrent TB and provide evidence needed to implement and scale the preferred ACF strategy. The specific aims are: Primary Aim 1: To conduct a non-inferiority randomized trial to measure the comparative effectiveness of two potentially implementable ACF strategies within India’s National TB Elimination Program (NTEP), conducted by existing NTEP healthcare workers (HCWs): (i) home-based ACF (HACF) and (ii) telephonic ACF (TACF). Primary Aim 2: To characterize implementation processes of the ACF strategies using the Reach, Effectiveness, Adoption, Implementation, … |
JONATHAN GOLUB; | 2021-01-29 |
| 332 | Development of A Rapid and Accurate Diagnostic Assay for Tuberculosis By Using New Sample Preparation and Detection Technique PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates new technique for diagnosis of tuberculosis. Among patients who are suspected with tuberculosis, participants will be tested conventional method including Xpert TB/RIF assay, and new diagnostic technique using homobifunctionalImidoesters compounds. |
SEI WON LEE; | 2021-01-28 |
| 333 | A Study to Evaluate The Effectiveness of E-IMCI Implementation Compared to Standard of Care for Sick Children Aged Under Five Years in Primary Health Care Clinics in KwaZulu-Natal, South Africa PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The research hypothesis is that sick children attending primary health care (PHC) clinics who are managed by IMCI-trained health workers (HWs) using electronic Integrated Management of Childhood Illness guidelines (e-IMCI) receive better quality of care compared to children managed by HWs using conventional paper-based IMCI (pIMCI). The aim of the study is to evaluate the effectiveness of e-IMCI to improve care for sick children under five years attending PHC clinics in one district in KwaZulu-Natal, … |
CHRISTIANE HORWOOD; | 2021-01-22 |
| 334 | Phase 2a Randomised Double-blind Placebo-controlled Trial to Assess Safety, Efficacy of Artesunate & Curcumin in Crohn’s Disease Patients, Who Continue to Have Mild to Moderate Disease Activity on An Adequate Dose of Azathioprine PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center phase 2a, randomised double-blind, placebo-controlled factorial design, proof of concept trial. Patients with Crohn’s disease who are on an adequate dose of azathioprine and still continue to active disease (CDAI > 150 and c-reactive protein > 6) will be enrolled. Forty patients will be randomised in a 1:1:1:1 ratio into 4 groups in a 2×2 factorial design to receive artesunate 200 mg PO daily for 2 weeks and / or Curcumin 2 gm PO daily for 3 months or placebo. Treatment Curcumin x 13 weeks Placebo C x 13 weeks Artesunate x 2 weeks Group 1 Group 2 Placebo A x 2 weeks Group 3 Group 4 During the treatment period and follow up period patients will be continued on their regular dose of azathioprine and 5-aminosalicylic acid with no change allowed during the study period. Patients will maintain a daily diary of symptoms and adverse events. Scheduled hospital visits with blood and stool tests will be at baseline, week 1, month 1, month 3 and month 6. Primary endpoint will be remission (defined as CDAI < 150) at 3 months |
UDAY C GHOSHAL; | 2021-01-21 |
| 335 | Repurposing A Lipid Lowering Drug to Treat Tuberculosis: Effectiveness of Statins As Adjuvant to Treatment of Pulmonary Tuberculosis in Nigeria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is caused by mycobacterial organism. It is the leading infectious disease cause of death globally, with more than 10 million new cases and over 2 million deaths annually. Developing countries bear the greatest brunt of the disease. The long duration of current treatment is associated with poor compliance, thereby contributing to frequent relapses and to the emergence of drug-resistant TB. In addition, individuals who have been clinically cured may have lung damage, which could be permanent. Therefore, … |
ADEWOLE OLUFEMI; | 2021-01-19 |
| 336 | Xpert MTB/RIF Ultra Assay for The Detection of Mycobacterium Tuberculosis (MTB) in Bronchoalveolar Lavage (BAL) for Pulmonary TB and Endobronchial Ultrasound Guided Transbronchial Needle Aspiration (EBUS-TBNA) Samples for Mediastinal TB PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective observational multi-centre UK study will evaluate Xpert MTB/RIF Ultra for the detection of Mycobacterium tuberculosis (MTB) in bronchoalveolar lavage (BAL) samples for pulmonary TB and endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) samples for mediastinal TB and compare the diagnostic performance against conventional modalities (smear, culture, cytology) as well as to a clinical composite diagnosis. This will be using a clinical expert panel reviewing data blindly. The Investigators will assess the performance of Xpert Ultra by calculating the sensitivity, specificity, … |
ONN MIN KON; | 2021-01-15 |
| 337 | The Effect of High Dose Rifampicin on The Activity of Cytochrome P450 Enzymes and P-glycoprotein in Patients With Pulmonary Tuberculosis: A Cocktail Phenotyping Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Higher doses of rifampicin as a means of more efficient use of this pivotal TB drug has shown promising results and might become standard in future. This means that higher doses of rifampicin will be co-administered with many other drugs taken by TB patients, including anti-retroviral, anti-diabetic, cardiovascular and other drugs. Therefore, in this study the aim is to quantitatively assess the drug interaction potential of high dose rifampicin (~40 mg/kg daily dose, … |
RADBOUD UNIVERSITY MEDICAL CENTER | 2021-01-07 |
| 338 | DIAGNOSIS of PULMONARY TUBERCULOSIS Through HUMAN BREATH TEST Center: Douala – CAMEROON PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is one of the top 10 causes of death in the world. More than 95% of TB deaths are in middle- and middle-income countries. Low incomes and long-term diagnosis promote this persistence. In 2017, Cameroon was the 3rd in the top of 20 countries with the highest estimated numbers of incident TB cases among people living with HIV, based on the severity of their TB burden. World Health Organization (WHO) encourages the introduction of rapid, non-invasive and cheaper screening tests. In this scope, … |
YOLANDE CHRISTELLE KETCHANJI MOUGANG; | 2021-01-05 |
| 339 | Evaluation of The Effectiveness and Cost-effectiveness of A Community-delivered Integrated Malaria Elimination (CIME) Model in Myanmar: An Open Stepped-wedge Cluster-randomised Controlled Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: In Myanmar, community health workers, known as malaria volunteers, have played a key role in reducing the malaria burden in the malaria control phase, providing essential malaria services in rural areas where the coverage of formal health services is limited. However, the community-delivered models that have worked well for malaria control may not work well for malaria elimination. In parallel with switching from interventions for malaria control to those for elimination, the motivation and social importance of malaria volunteers has declined along with the decline of the malaria burden. To sustain volunteer motivation, … |
FREYA FOWKES; | 2021-01-01 |
| 340 | A Randomized Double Blind Placebo Controlled Trial of Rifapentine and Isoniazid for Prevention of Tuberculosis in People With Diabetes PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus (DM) increases susceptibility to Tuberculosis (TB) and worsens TB patient outcomes. The number of patients with combined TB and DM now outnumbers that of combined TB and HIV and it has been estimated that 15-30% of TB disease may be attributable to diabetes globally. This may be expected to rise substantially as DM prevalence increases. Treatment of Latent TB Infection (LTBI) in this population will likely have a significant clinical benefit. Similar to HIV-infected individuals, … |
NYANDA ELIAS NTINGINYA; | 2021-01-01 |
| 341 | Efficacy and Safety of Cyclophosphamide in The Treatment of Refractory Proliferative Arachnoiditis in Central Nervous System Tuberculosis- A Randomized Double Blinded Placebo Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tubercular meningitis occurs in around 10% of those with extrapulmonary tuberculosis and is a major cause of mortality and morbidity. Inspite of effective Anti-tubercular drugs, still around 30% of patients develop complications due to arachnoiditis such as spinal tubercular radiculomyelitis, optico-chiasmatic arachnoiditis, development of new tuberculomas after starting therapy etc. which are probably immune mediated inflammatory responses due to paradoxical reaction to ATT. The management of arachnoiditis is far from satisfactory. High dose methylprednisolone, intrathecal hyaluronic acid, thalidomide have been tried in small case series and case reports. However, … |
ARUNMOZHIMARAN ELAVARASI; | 2021-01-01 |
| 342 | Mansonella Perstans Effects on BCG Vaccine-induced Protection Against Childhood Tuberculosis (TB) As Well As TB Disease Severity and Recovery in Cameroon (MAP-TB) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Filarial nematodes modulate the host immune response to promote regulatory and T helper type 2 immune responses, which were shown to influence concomitant infections. Indeed, several studies showed that increased susceptibility and worsened disease course of HIV, tuberculosis (TB) and malaria in filarial endemic regions. Moreover, the investigators demonstrated that M. perstans infections polarize and suppress immune responses with likely consequences for concomitant infections and vaccine-induced protection. In addition, … |
MANUEL RITTER; | 2020-12-01 |
| 343 | Impact of The Respiratory Isolation on The Quality of Life in Patients Hospitalized for Tuberculosis or COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The respiratory isolation could have a harmful impact on the well-being of patients, especially in a psychological point of view such as anxiety and depression disorders or through the relationship with medical team and/or relatives but also in terms of informations. The evaluation of the impact of respiratory isolation in patients hospitalized for tuberculosis or COVID-19 could allow to identify the different kinds of problems encountered by these patients (physical, psychological, sociological, informations, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2020-12-01 |
| 344 | Vitamin D Supplementation Effect In Children With Pulmonary Tuberculosis Treatment: Randomized Double Blind Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the vitamin D supplementation effect to improve clinical outcomes in children with pulmonary tuberculosis treatment. This randomized, double-blind control trial with a cohort design was conducted in West Borneo from December 2020 – July 2021. A Total 84 patients met the inclusion criteria; aged 6 to 18 years old, newly diagnosed with pulmonary tuberculosis with vitamin D insufficiency. Only 80 patients completed the six months follow-up. The intervention was 1,000 IU vitamin D or placebo for six months treatment. Comparison of clinical conditions and nutritional status are analyzed statistically. |
LIANDA TAMARA; | 2020-12-01 |
| 345 | TB Treatment Support Tools: Refinement and Evaluation of An Interactive Mobile App and Direct Adherence Monitoring on TB Treatment Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this study is to conduct a Randomized Clinical Trial (RCT) to evaluate a tuberculosis treatment support tool (TB-TST), a cellular phone app developed using user-centered design principles and a paper-based drug metabolite urine test strip modified for home use for testing the presence of isoniazid drug metabolites in urine to directly monitor adherence to treatment, to improve treatment outcomes for patients with TB receiving self-administered treatment (SAT). Poor medication adherence to TB regimens, along with challenges in monitoring patients and returning them to treatment, … |
FERNANDO A RUBINSTEIN; | 2020-11-17 |
| 346 | Development of Device Kit for Rapid and Sensitive Diagnostic Method for The Tuberculosis; Using Amine Groups Called HI(Homobifunctional Imidoesters),Negative Charge of The Pathogen and Formed Electrical Bonding to Isolate and Concentrate The Pathogen PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It is intended for patients who have been admitted to the outpatient or emergency room or are hospitalized For patients who diagnose pulmonary tuberculosis or extrapulmonary tuberculosis using Xpert TB/RIF, additionally, diagnose pulmonary tuberculosis or extrapulmonary tuberculosis using a new diagnostic method, and check the test results. Check whether the tuberculosis bacteria were actually cultured in the sample in the future, and compare the sensitivity and specificity in each test. Validation in animal model In an animal model (rat) with chronic obstructive pulmonary disease that shows similar characteristics to tuberculosis destructive lung, … |
SEI WON LEE; | 2020-11-17 |
| 347 | A Randomized, Placebo-controlled, Observer-blind, Phase 2 Study to Evaluate Safety and Immunogenicity of The Investigational M72/AS01E Mycobacterium Tuberculosis (Mtb) Vaccine in Virally Suppressed, Antiretroviral-treated Participants With Human Immunodeficiency Virus (HIV) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety and immunogenicity of M72/AS01E vaccination in virally suppressed, antiretroviral-treated participants with human immunodeficiency virus infection (HIV). |
BILL & MELINDA GATES MEDICAL RESEARCH INSTITUTE | 2020-11-17 |
| 348 | BCG and Plasma Amyloid in Non-Demented Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: BCG vaccination, the most widely used vaccination in the world, is used to reduce risk of tuberculosis infection; it is used for other mycobacterial infections as well, benefiting leprosy and Buruli ulcer. BCG has heterologous effects that aids in an array of non-mycobacterial and viral infections as well as bladder cancer. It is the heterologous effect, sometimes called the off-target effect that may offer benefit in Alzheimer’s disease. Population studies and studies of adults receiving BCG show a lessened risk of Alzheimer’s disease. The study will see if BCG vaccination will alter a plasma test for amyloid, … |
COAD T DOW; | 2020-11-09 |
| 349 | Field Evaluation of A Point-of-care Triage Test for Active Tuberculosis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Tuberculosis (TB) is a bacterial lung infection leaving 3.6 million people undiagnosed each year. Thirty percent of infected people do not receive treatment due to failure to receive diagnostic testing or being lost to follow-up between testing and availability of results. Objective: To refine and field-validate a point-of-care (POC) finger stick blood test for use worldwide to triage for active TB. Eligibility: Persons aged 12 – 70 years with symptoms suggestive of TB disease Study design: Participants will be screened with: Medical history Physical exam HIV test, diabetes screening Blood (finger stick and venous), … |
GERHARD WALZL; | 2020-11-05 |
| 350 | Managing Appropriate Prescribing in Primary Care COPD Patients With Comorbidities: Evaluation of The Desktop Helper (Number 10) in A Pragmatic Cluster Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: Reducing inappropriate medications for primary care COPD patients with comorbidities (‘medication-comorbidity clashes’), by evaluation of the Desktop Helper (number 10) in a pragmatic cluster randomized controlled trial. Study design: A four-arm pragmatic cluster randomized controlled trial (cluster RCT), which will be conducted in GP practices in the Netherlands. In the cluster RCT, the control condition (arm 1: care as usual) will be compared with three intervention arms (i.e. arm 2: the ‘Desktop Helper (number 10)’ , arm 3: an e-learning module, … |
JANWILLEM KOCKS; | 2020-11-01 |
| 351 | A Randomised, Double Blind (Sponsor Unblinded), Placebo-controlled, First Time in Human Study to Evaluate The Safety, Tolerability and Pharmacokinetics of Single and Repeat Oral Doses and The Food Effect of GSK2556286 in Healthy Adult Participants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a first time in human (FTIH) study to evaluate the safety, tolerability and pharmacokinetics (PK) of single and repeat ascending doses of GSK2556286 in healthy adult participants. Food effect (FE) cohorts will investigate the influence of food on the PK of GSK2556286. The study will be conducted in two parts. Part A will be a single ascending dose (SAD) including up to 11 cohorts (Cohort 1A to cohort 11A) and Part B will be a multiple ascending dose (MAD), including up to 4 cohorts (Cohort 1B to cohort 4B). |
EDWARD BANHAM-HALL; | 2020-10-30 |
| 352 | Economic Evaluation of New MDR TB Regimens (PRACTECAL EE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current treatment regimen for MDR-TB has poor outcomes and costs of treating MDR-TB are greater than treating drug susceptible TB, both in terms of health service and patient-incurred costs. Urgent action is needed to Identify short, effective and tolerable treatments for people with MDR-TB. The PRACTECAL economic evaluation sub-study (PRACTECAL-EE) will take place alongside the TB PRACTECAL trial, aiming to assess the costs to patients and providers of such regimens and to estimate the cost-effectiveness and poverty impact of an introduction of new MDR-TB regimens in the three countries participating in the main study. |
SEDONA SWEENY; | 2020-10-20 |
| 353 | A Phase II Clinical Study of Transarterial Chemoembolization (TACE) Plus Hepatic Arterial Infusion Chemotherapy (HAIC) With Oxaliplatin and Raltitrexed for Barcelona Stage C Hepatocellular Carcinoma (HCC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose：explore the effectiveness and safety of transarterial chemoembolization (TACE) plus Hepatic Arterial Infusion Chemotherapy (HAIC) with oxaliplatin and raltitrexed for Barcelona stage C hepatocellular carcinoma (HCC) |
ZHU XU; | 2020-10-20 |
| 354 | Impact of Mobile Health Interactive Software on Tuberculosis Treatment Outcomes: The Call for Life (CFLU-TB) Project PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be an open-label Randomized Controlled Trial (RCT) to determine the effect of Call for Life TB (CFLU-TB) on Tuberculosis (TB) treatment success in patients with non-drug resistant Tuberculosis receiving care at three public health facilities, Kisenyi Health Centre IV, Kasangati Health Centre IV and Kiryandongo government Hospital. Call for Life TB will employ a mobile health Health technology called CONNECT FOR LIFE™ to provide SMS or Interactive Voice Response patient support. This support will be in the form of clinic appointment, daily pill reminders, reminders, … |
DATHAN BYONANEBYE MIREMBE; | 2020-10-19 |
| 355 | Assessment of A Viral Load Result-driven Automated Differentiated Service Delivery Model for Participants Taking Antiretroviral Therapy in Lesotho PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This cluster randomized clinical trial at 18 nurse-led rural health centers in Lesotho will test an automated differentiated service delivery model using viral load results, other clinical characteristics and participants’ preference to automatically triage participants into groups requiring different levels of attention and care. |
SWISS TROPICAL & PUBLIC HEALTH INSTITUTE | 2020-10-14 |
| 356 | European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) SARS-CoV-2 Antibody Study Protocol PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Scientific knowledge about the COVID-19 pandemic and the virus that is causing it (SARS-CoV-2) is developing rapidly, and the investigators have a clearer idea of the population groups who are at higher risk of becoming infected, having serious illness, and dying. However, less is known about COVID-19 in children, adolescents and young adults living with HIV. It is not yet known whether, or how, HIV affects people’s risk of being infected with the virus or becoming ill. This study aims to find out whether children and adolescents living with HIV have had the COVID-19 virus, … |
PENTA FOUNDATION | 2020-10-14 |
| 357 | A Prospective Observational Study on Assessment of The Soluble Urokinase Plasminogen Activator Receptor in Adult Patients With Covid-19 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is the soluble form of the cell membrane-bound protein urokinase plasminogen activator receptor (uPAR), which is expressed mainly on immune cells, endothelial cells, … |
ATHANASIOS CHALKIAS; | 2020-10-11 |
| 358 | Aerosol Transmission of Severe Acute Respiratory Syndrome Coronavirus: A Dilemma Related Papers Related Patents Related Grants Related Experts View Highlight: There is little information on the characteristics of airborne severe acute respiratory syndrome coronavirus containing aerosols, their concentration, or their infectivity.The aim was to determine airborne severe acute respiratory syndrome coronavirus transmission, their infectivity in different areas such as patient’s room and in medical staff área. |
VANINA LAURA PAGOTTO; | 2020-10-08 |
| 359 | Identifcation of Biomarkers for Active Pulmonary Tuberculosis Using A Metabolomics Approach: A Prospective Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This experiment is designed to analyze the metabolites in body fluids from patients with active tuberculosis and latent tuberculosis infection also with health volunteer, then combine the metabolic product features with clinical characteristics, to develop a kind of metabolites targets to evaluate the progress in tuberculosis, thus provide a basis for further utilization of humoral metabolites in the diagnosis of tuberculosis. |
PINTONG HUANG; | 2020-10-01 |
| 360 | Diagnostic Value of Chest Ultrasound in Detecting Causes of Radiological Opacities in Comparison to CT Scan Among Children at Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the accuracy of chest ultrasound for diagnosis of different lung lesions in comparison to the gold standard among children. |
DHEKRA ASHOUR ABOUD SALEM; | 2020-10-01 |
| 361 | The Effect of Rifampin on Etonogestrel Concentrations in Contraceptive Implant Users PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is important for women taking rifampin to be aware if they are at greater risk of an unintended pregnancy while on the implant. An unintended pregnancy has many social, emotional, and financial impacts on women and society. Rifampin is also a Class C medication for pregnancy and could have potential negative effects on a developing fetus. Additionally, women considering rifampin for treatment of LTBI face additional risks with an unintended pregnancy, … |
UNIVERSITY OF COLORADO DENVER | 2020-09-23 |
| 362 | Using BCG Vaccine to Enhance Non-specific Protection of Senior Citizens During The COVID-19 Pandemic. A Randomized Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The virus SARS-CoV-2 has spread rapidly throughout the world. Seniors are at high risk of severe COVID-19 when infected. Bacille Calmette-Guérin (BCG) is a vaccine against tuberculosis, with protective non-specific effects against other infections; significant reductions in morbidity and mortality have been reported, … |
ANNE MARIE ROSENDAHL MADSEN; | 2020-09-15 |
| 363 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Guselkumab in Subjects With Active Lupus Nephritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of guselkumab in participants with active lupus nephritis (LN). |
JANSSEN RESEARCH & DEVELOPMENT | 2020-09-15 |
| 364 | Transmission of COVID19 in Crowded Environments PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: South Africa recorded it’s first coronavirus disease 2019 (COVID19) case on March 5, 2020. In response to the COVID19 outbreak World Health Organisation recommendations, South Africa implemented non-pharmaceutical recommendations. The major risk mitigation factors recommended by World Health Organisation and others – physical distancing and hygiene – are extremely difficult to implement in much of Africa. The investigators will conduct a randomised controlled trial to investigate the effect of an infection mitigation intervention to assess the effect on household transmission of severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 in household settings with an index patient diagnosed SARS-CoV-2 positive. |
LINDA-GAIL BEKKER; | 2020-09-14 |
| 365 | Role of Ultrasound Guided Percutaneous Transthoracic Core Needle Biopsy in Diagnosis of Peripheral Thoracic Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to calculate sensitivity, and accuracy of ultrasound guided percutaneous core needle biopsy in different thoracic tumors (lung, pleural, chest wall and mediastinal). |
MAHA FATHY; | 2020-09-12 |
| 366 | A Multi-center, Randomized, Positive-controlled Phase 2 Clinical Trial to Evaluate The Early Bactericidal Activity, Safety and Tolerability of WX-081 in Participants With Drug-naive&Susceptible or Drug-Resistant Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, parallel, open-label, positive-controlled Phase 2 clinical trial, which aims to evaluate the early bactericidal activity, safety and tolerability of WX-081 in patients with drug-naive&susceptible and drug-resistant tuberculosis. Also the efficacy of WX-081 will be explored in participants with drug-resistant tuberculosis. |
CHU NAIHUI; | 2020-09-12 |
| 367 | Computer Aided Screening for Tuberculosis in Low Resource Environments PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: People living with HIV (PLHIV) who require admission to hospital in WHO Africa region have poor outcomes. TB is very common in this group, but can be difficult to diagnose. The CASTLE trial aims to determine whether systematic screening for tuberculosis using digital chest X-ray with computer-aided diagnosis (DCXR-CAD) plus urine lipoarabinomannan testing with Fujifilm SILVAMP TB LAM (FujiLAM) plus usual care can improve admission outcomes for hospitalised PLHIV, compared to usual care alone. Our study is a single centre, unblinded, … |
RACHAEL M BURKE; | 2020-09-02 |
| 368 | Role of Short Course Rifapentine and Isoniazid for The Preventive Treatment for Latent Genital Tuberculosis in Women With Recurrent Implantation Failure: A Prospective Interventional Cohort Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the efficacy, safety and tolerability of the 1-month regimen of three times weekly rifapentine plus isoniazid in improving fertility outcome in recurrent implantation failure (RIF) patients with latent genital tuberculosis (LGTB), compared to no treatment and non-LGTB patients. |
WEN-HONG ZHANG; | 2020-09-01 |
| 369 | Impact of A Pharmacist-led Patient-centred Care Intervention Along With Text-Message Reminders, on The Management of Newly Diagnosed Tubercular Patients: A Protocol for A Randomized Controlled Trial’ PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to standardize the management of Pharmaceutical care with the two-way text messages and incentive for mobile usage during the treatment for tuberculosis patients, to improve the outcomes and compliance, reduce the risk of transmission and to evaluate the patient perspective in terms of their quality of life, shared decision making and satisfaction with services provided. |
FARMAN ULLAH KHAN; | 2020-09-01 |
| 370 | Evaluation of Serum Cytokine Values in Patients With Granulomatous Mastitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Granulomatous mastitis is a rare, chronic, benign inflammatory disease of the breast that plays a role in many varying etiologies, including infectious and non-infectious causes. Etiological reasons were examined in various studies, but neither etiology nor definite criteria for diagnosis were found. Our aim in this study is to examine the role of cytokines in differentiating the etiology of granulomatous mastitis and using it as a prognostic marker. |
UFUK OGUZ IDIZ; | 2020-09-01 |
| 371 | The Role of Trained Immunity in Fungal Infection and The Mechanism Behind It PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigator vaccinated 76 healthy BCG-naive participant with BCG, while 3 participants received. Half of BCG-vaccinated participants (n = 38) received an incremental dose of metformin for 6 days (up to 1,000 mg twice daily on day 6). On the day 0 (total 20; n = 10 for BCG vaccination, n = 10 for BCG vaccination plus taking metformin), day 14 (total 30; n=15 for BCG vaccination, n = 15 for BCG vaccination plus taking metformin), day 90 (total 26; n = 13 for BCG vaccination, n=13 for BCG vaccination plus taking metformin) of BCG vaccination, PBMCs were isolated, … |
ZHIBING LU; | 2020-09-01 |
| 372 | Impact of New Genomic Tools on The Management of Patients With Multidrug-resistant Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In the context of the emergence of cases of multidrug-resistant tuberculosis (MDR-TB) it is crucial to improve patient’s management. Therefore, assessing the place of innovative strategies enabling the diagnosis of those cases (e.g. WGS and Deeplex-MycTB) in the personalized care of patients with MDR-TB and the rationalization of medical biology procedures is a major issue. This project participates to these goals since the investigators will : (i) assess the diagnostic qualities and the performance of the different innovatives strategies enabling detection of resistance to anti-tuberculosis drugs, … |
ALEXANDRA AUBRY; | 2020-08-29 |
| 373 | A Phase 2 Trial to Evaluate The Early Bactericidal Activity and Safety of Meropenem With Amoxicillin/Clavulanate Plus Either Pyrazinamde or Bedaquiline in Adults With Newly Diagnosed Rifampicin-susceptible Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A single-center, open-label clinical trial to determine the early bactericidal activity (EBA) and safety of the combination of meropenem and amoxicillin/clavulanate plus pyrazinamide vs. meropenem and amoxicillin/clavulanate plus bedaquiline administered for 14 consecutive days. This study forms part of a series of 2-week EBA studies to determine the relative bactericidal activity of several new or repurposed anti-tuberculosis agents from which to determine the most effective and safe combination to evaluate in larger and longer duration regimen-based trials. |
VERONIQUE R DE JAGER; | 2020-08-17 |
| 374 | Rosuvastatin Evaluation As A Tuberculosis Treatment Adjunct PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial aims to determine whether the addition of rosuvastatin to standard TB therapy in pulmonary tuberculosis results in accelerated of sputum culture conversion. The trial will also investigate potential new biomarkers of sterilising activity and immune-modulatory activity. |
NICHOLAS PATON; | 2020-08-12 |
| 375 | The Impact of Malnutrition on Immune Responses to Tuberculosis in Indian Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess immune responses to Mtb in children with MAM compared to well-nourished children and to evaluate the impact of a nutrition intervention on these immune responses. |
AISHWARYA VENKATARAMAN; | 2020-08-01 |
| 376 | A Randomized, Controlled, Multi-center Clinical Trial of Short Course Treatment for Newly Diagnosed Rifampicin Resistant Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, controlled, multi-center clinical study. The main purpose of this study was to study the efficacy and safety data of total oral short-term therapy as an alternative to injection in the treatment of newly diagnosed RR-TB patients. |
CHU NAIHU; | 2020-08-01 |
| 377 | Evaluation of Immune Cells in Patients With Granulomatous Mastitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Granulomatous mastitis is a rare, chronic, benign inflammatory disease of the breast that plays a role in many varying etiologies, including infectious and non-infectious causes. Etiological reasons were examined in various studies, but neither etiology nor definite criteria for diagnosis were found. Our aim in this study is to examine the role of immunophenotyping in differentiating the etiology of granulomatous mastitis and using it as a prognostic marker. |
UFUK OGUZ IDIZ; | 2020-08-01 |
| 378 | Performance Evaluation of BCG Vaccination in Healthcare Personnel to Reduce The Severity of SARS-COV-2 Infection in Medellín, Colombia, 2020 Related Papers Related Patents Related Grants Related Experts View Highlight: Until the first half of April, Colombia has more than 2,800 infected cases and a hundred deaths as a result of COVID-19, with Antioquia being the third department with the highest number of cases. Official records indicate that, in Colombia, the first case was diagnosed on March 6, 2020, corresponding to a patient from Italy. However, in conversations with several infectologists and intensivists from Medellín, … |
JUAN C CATAÑO; | 2020-08-01 |
| 379 | Multidrug Resistant Tuberculosis Close Contacts Tracing in China PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate the incidence of etiologically confirmed or clinically diagnosed active tuberculosis in close contacts of MDR-TB patients. |
WEN-HONG ZHANG; | 2020-07-21 |
| 380 | Safety and Effectiveness of Delamanid-containing Regimen for Treatment of Patients With Multidrug-resistant Tuberculosis in China PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to monitor and evaluate the safety and effectiveness of Delamanid in combination with an optimal background regimen (OBR) of anti-TB drugs for treatment of MDR-TB. |
LIANG LI; | 2020-07-16 |
| 381 | Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention: The 3HP Options Implementation Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention (3HP Options Implementation Trial) study will be a three-arm, open-label, parallel, randomized trial. This hybrid effectiveness-implementation trial will be conducted among people living with HIV infection (PLHIV) enrolled in HIV/AIDS care at the Mulago Immune Suppression Syndrome (i.e., HIV/AIDS) clinic in Kampala, … |
ADITHYA CATTAMANCHI; | 2020-07-13 |
| 382 | DOT Selfie: A Mobile Health Intervention With Transfer of Social Bundle Incentives to Increase Treatment Adherence in Tuberculosis Patients in Uganda: A Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled trial (RCT) to determine whether Video Observed Treatment (VDOT) using social internet bundle incentives for tuberculosis (TB) is an effective way to improve medication adherence in TB treatment, compared with standard in-person treatment (home-/ community-based). The study will include two study arms: one will receive TB treatment using the standard in-person DOT, and the other through VDOT. All patients (regardless of study arm) will receive daily TB treatment under home- or community-based observation . For patients in the In-person DOT arm, … |
JULIET NABBUYE SEKANDI; | 2020-07-13 |
| 383 | A Multi-centre, Randomised, Double-blind, Placebo-controlled Phase III Clinical Trial Evaluating The Effect of BCG Vaccination on The Incidence and Severity of SARS-CoV-2 Infections Among Healthcare Professionals During The COVID-19 Pandemic in Poland PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Countries that have not carried out universal mass vaccination against tuberculosis (BCG) have been shown to have higher incidence and death rates due to COVID-19 than countries with mass, … |
HANNA CZAJKA; | 2020-07-07 |
| 384 | Tuberculosis Screening With AeoNose and CAD4TB in Paraguayan Prisons PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Two diagnostic tools for TB screening in high risk groups need additional assessment: the AeoNose™, an ‘electronic nose device’ for breath sampling, and digital chest X-ray (CXR) with computer aided detection with CAD4TB® software. This study will systematically screen prisoners and its’ employees for TB, test the diagnostic performance of AeoNose™ and CAD4TB (both individually and together) as a TB screening tool and and establish Mycobacterium tuberculosis epidemiology in Paraguayan prisons. |
CECILE MAGIS-ESCURRA; | 2020-07-01 |
| 385 | Study to Evaluate The Effectiveness of BCG Vaccine in Reducing Morbidity and Mortality in Elderly Individuals in COVID-19 Hotspots in India PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: SARS-CoV2 viral infection is spreading rapidly throughout the world and in India the epidemic poses a major threat to the public health system. Elderly individuals, especially those with diabetes, hypertension, other chronic diseases are at high risk of mortality. Strategies to protect these individuals are desperately needed to safeguard continuous patient care. Bacille Calmette-Guérin (BCG) is a vaccine against tuberculosis, with protective non-specific effects against other respiratory tract infections in in-vitro and in-vivo studies, … |
PADMAPRIYADARSINI CHANDRASEKARAN; | 2020-07-01 |
| 386 | A Prospective Household Study of SARS-CoV-2, Influenza, and Respiratory Syncytial Virus Community Burden, Transmission Dynamics and Viral Interaction in South Africa (the PHIRST-C Study) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to characterize the community burden (including the clinical features) and transmissibility of SARS-CoV-2 within the context of a functional antibody response. In addition,the study will assess the effect of the interaction of SARS-CoV-2 with influenza virus and RSV on disease severity and transmission dynamics. A household-level prospective cohort study will be conducted in one rural and one urban community located in Mpumalanga Province and North West Province, … |
KATHLEEN KAHN; | 2020-07-01 |
| 387 | Prevalence of Latent Tuberculosis in High Risk Children Attending Pediatric Hospital of Assiut University PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: identify the prevalence of latent tuberculosis (according to new guideline ;NICE tuberculosis) among these high risk groups of children and notify ministry of health |
NASEF SAFWAT LEMBY; | 2020-07-01 |
| 388 | Increasing Notifications of Tuberculosis From Private Practitioners: A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is the third leading cause of death in Indonesia. Disturbingly, the prevalence survey showed that over half of TB cases in Indonesia are not notified. The huge private sector in Indonesia, comprising an estimated 70,000 practitioners, provides over 50% of health care but notifies less than 10% of all diagnosed TB cases. INSTEP2 is a cluster randomised controlled intervention trial. The multi-component public health intervention will be administered to private practitioners (PP) in Community Health Centre (CHC) clusters. The change in the number of TB notifications over 12 months before, and 12 months after, … |
PANJI FORTUNA HADISOEMARTO; | 2020-07-01 |
| 389 | SMS-based Mobile Health Intervention for Nutritional Status and Treatment Outcomes Among TB Patients in Addis Ababa, Ethiopia: A Cluster Randomized Trial (CRT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Ethiopia is one of the high burden Tuberculosis countries and Tuberculosis is still the leading cause of mortality due to communicable diseases in the country. Nutritional status is one of the predictors of TB treatment outcomes. Thus, the current practices need integration of nutritional intervention in the DOT using Mobile health intervention. However, to investigator’s knowledge, there is no sufficient evidence on the effect SMS text Messaging Mobile Health intervention on nutritional status and TB treatment outcomes in Ethiopia. |
ZEKARIYAS SAHILE; | 2020-07-01 |
| 390 | A Pilot Study of Mobile Directly Observed Therapy (mDOT) for Immunosuppressant Adherence in Adult Liver Transplant Recipients Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppressant medication adherence among adult liver transplant recipients. The investigators aim to test this by randomly assigning transplant recipients to the intervention (use of an mHealth app to manage and track their immunosuppression regimen) or control arm (standard of care) upon discharge from their initial transplant hospitalization, and tracking medication adherence over time. The study population will be approximately 50 adult liver transplant recipients at the Johns Hopkins Hospital. |
MACEY HENDERSON; | 2020-06-29 |
| 391 | A Pilot Study of Mobile Directly Observed Therapy (mDOT) for Immunosuppressant Adherence in Adolescent Liver Transplant Recipients Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppression medication adherence among adolescent liver transplant recipients. The investigators aim to test this by recruiting adolescent (ages 14-21) liver transplant recipients to use an mHealth application to record themselves taking their immunosuppression medications, and tracking medication adherence over time. The study population will be approximately 25 adolescent liver transplant recipients at the Johns Hopkins Hospital. |
MACEY HENDERSON; | 2020-06-18 |
| 392 | Prognostic Value of Serum Interleukin-6 (IL-6) and Soluble Interleukin-6 Receptor (sIL-6R) in Severe Coronavirus Disease (COVID-19) Pneumonia Treated With Tocilizumab – A Prospective Single Center Study (UHID-COVID19) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single arm, prospective, observational, single center study to assess the role of interleukin-6 (IL-6) and soluble interleukin 6 receptor (sIL-6R) as predictors of efficacy and safety outcomes in patients with severe coronavirus disease (COVID-19) pneumonia treated with tocilizumab. At least 30 patients will be enrolled who are diagnosed with severe COVID-19 pneumonia and meet the entry criteria. |
ROK CIVLJAK; | 2020-06-16 |
| 393 | Xpert MTB/RIF Test As The Initial Diagnostic Test in The Diagnosis of Pulmonary Tuberculosis: A Pragmatic Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Currently in Taiwan, most clinicians use sputum smear and culture for the diagnosis of pulmonary tuberculosis (TB) and apply nucleic acid amplification (NAA) test in a selected manner. In 2013, the World Health Organization issued conditional recommendation that Xpert MTB/RIF may be used rather than conventional microscopy and culture as the initial diagnostic test in all adults suspected of having TB. The newly published Taiwan guidelines for TB diagnosis and treatment has recommended NAA test, together with smear and culture, … |
CHEN-YUAN CHIANG; | 2020-06-15 |
| 394 | Artificial Neural Network As Diagnostic Tools For Rifampicin-Resistant Tuberculosis In Indonesia: A Predictive Model Study and Economic Evaluation PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Title: Artificial Neural Network as Diagnostic Tools For Rifampicin-Resistant Tuberculosis In Indonesia. A Predictive Model Study and Economic Evaluation. Background: Drug-resistant tuberculosis has become a global threat particularly in Indonesia. The need to increase detection, followed by appropriate treatment is a concern in dealing with these cases. The rapid molecular test (specifically for detecting rifampicin-resistant) is now being utilized in health care service, particularly at primary care level with some challenges including the lack of quality control (including how to obtained and treat the specimen properly prior to the examination) which then, … |
BUMI HERMAN; | 2020-06-15 |
| 395 | Refining Multidrug Tuberculosis Treatment With The Ultra Short All Oral Regimen PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to pyrazinamide) treatments for 24 to 32 weeks (regimen consisted of clofazimine for 36~44 weeks) in subjects with multidrug-resistant tuberculosis (MDR-TB) compared to WHO standardized shorter regimen of 36-44 weeks. |
WEN-HONG ZHANG; | 2020-06-01 |
| 396 | Electronic Pillbox-enabled Self-administered Therapy Versus Standard Directly Observed Therapy for Tuberculosis Medication Adherence and Treatment Outcomes in Ethiopia: A Multicenter Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To address the multifaceted challenges associated with tuberculosis (TB) in-person directly observed therapy (DOT), the World Health Organization recently recommended countries maximize the use of digital adherence technologies. Sub-Saharan Africa needs to investigate the effectiveness of such technologies in local contexts and proactively contribute to global decisions around patient-centered TB care. This study aims to evaluate the effectiveness of pillbox-enabled self-administered therapy (SAT) compared to standard DOT on adherence to TB medication and treatment outcomes in Ethiopia. It also aims to assess the usability, acceptability, … |
TSEGAHUN MANYAZEWAL; | 2020-06-01 |
| 397 | Pharmacokinetic Evaluation and Local Tolerability of Dry Powder Amikacin Via The Cyclops™ in Patients With Drug Susceptible Tuberculosis Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Multidrug-resistant tuberculosis (MDR-TB) is defined as tuberculosis resistant to isoniazid and rifampicin. The incidence of MDR-TB worldwide is 3.9% for new cases and 21% for previously treated cases. However, the incidence of previously treated cases can rise to above 50% in eastern European countries. With increasing frequency of MDR-TB (and even extensively drug-resistant types), morbidity and mortality due to TB fail to decline worldwide. Amikacin, one of the drugs against MDR-TB, … |
ONNO AKKERMAN; | 2020-06-01 |
| 398 | Phase Ib Clinical Trial Evaluating The Safety and Immunogenicity of Freeze-dried Recombinant Tuberculosis Vaccine (AEC / BC02) in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Single-center, single-dose, placebo-controlled, open-label trials were used to evaluate the safety and immunogenicity of low-dose adjuvants and low-dose vaccines in the upper arm deltoid muscle intramuscularly in the double negative population. Thirty (PPD-QFT-) healthy adult subjects aged 18-45 were selected and divided into placebo group, low-dose adjuvant group, and low-dose vaccine group. During the test, each subject must not change groups and inoculate drugs. Every two weeks (0-2-4-6-8-10 weeks), alternately inject a dose of placebo or left and right upper arm deltoid muscles. Low-dose adjuvant or low-dose vaccine, a total of 6 doses. |
ZHAOLIN HUANG; | 2020-05-27 |
| 399 | BARICIVID-19 STUDY: MultiCentre, Randomised, Phase IIa Clinical Trial Evaluating Efficacy and Tolerability of Baricitinib As Add-on Treatment of In-patients With COVID-19 Compared to Standard Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There is urgent need of an effective therapy for Covid-19. To date, the best treatment of SARS-CoV-2 infection is unknown. Baricitinib has been identified as potential treatment for 2019-nCoV acute respiratory disease, … |
FRANCESCO MENICHETTI; | 2020-05-20 |
| 400 | Using BCG Vaccine to Enhance Non-specific Protection of Health Care Workers During The COVID-19 Pandemic. A Randomized Controlled Multi-center Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The COVID-19 pandemic challenges the available hospital capacity, and this will be augmented by absenteeism of healthcare workers (HCW). HCW are at high risk, currently HCW constitute 20% of all the COVID-19 cases in Denmark. Strategies to prevent absenteeism of HCW are urgently needed. Bacille Calmette-Guérin (BCG) is a vaccine against tuberculosis, with protective non-specific effects against other infections; significant reductions in morbidity and mortality have been reported, … |
FREDERIK SCHALTZ-BUCHHOLZER; | 2020-05-18 |
| 401 | Bioaerosol Sampling of Patients With Suspected Pulmonary Tuberculosis: A Study Protocol PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is transmitted in bioaerosols containing Mycobacterium tuberculosis (Mtb). Mtb-containing bioaerosols are likely related to host infectiousness and central to ongoing TB transmission. No routine diagnostic assay exists to measure Mtb in bioaerosols. Furthermore, published studies of Mtb in bioaerosol samples, have been limited to individuals with sputum-positive pulmonary TB. Currently TB diagnosis is based on clinical symptoms and sputum laboratory findings. However, … |
DESMOND TUTU HIV FOUNDATION | 2020-05-15 |
| 402 | Reducing Morbidity and Mortality in Health Care Workers Exposed to SARS-CoV-2 By Enhancing Non-specific Immune Responses Through Bacillus Calmette-Guérin Vaccination, A Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A novel betacoronavirus, SARS-CoV-2, is spreading rapidly throughout the world. A large epidemic in South Africa may overwhelm available hospital capacity and healthcare resources which would be worsened by absenteeism of healthcare workers and other frontline staff (HCW). Strategies to prevent morbidity and mortality of HCW are desperately needed to safeguard continuous patient care. Bacillus Calmette-Guérin (BCG) is a vaccine against tuberculosis (TB), with protective non-specific effects against other respiratory tract infections in in vitro and in vivo studies, … |
TASK APPLIED SCIENCE | 2020-05-04 |
| 403 | Effects of Pulmonary Tuberculosis Sequelae on Functional Outcomes in Patients With COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It is known that there is a complex relationship between tuberculosis and COPD. Post-tuberculosis airway disease or COPD associated with tuberculosis occurs in a significant portion of tuberculosis patients. However, it was observed that mortality rates and exacerbation rates of COPD patients with tuberculosis sequel were higher. However, the effect of tuberculosis sequela on functional outcomes in COPD patients has not been investigated in the studies. The aim of this study is to determine whether the previous tuberculosis sequelae has a functional effect on patients with COPD. |
ILKNUR NAZ; | 2020-05-01 |
| 404 | A Phase-II Clinical Trial for First Line Treatment of Stage II/III Covid-19 Patients to Treat Hyperinflammation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: RuxCoFlam is a single arm, non-randomized open phase II trial for front line treatment of Covid-19 patients with defined hyperinflammation. |
MED. ANDREAS HOCHHAUS; | 2020-04-22 |
| 405 | To Assess The Efficiency and Satisfaction of Pharmacist Giving Patient-centred Advice on Telephone Consultation in TB Patients: Experience of The COVID-19 Pandemic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic might be an opportunity to review and refine our practices in anti TB treatment. For the follow-up of selected patients, telephone consultations may be efficient and cost-effective. The aim of the study is to assess the efficiency and the satisfaction with telephone consultation for the pharmacist and the TB patient. The study was conducted in tertiary care hospital TB control centres patients. |
FARMAN ULLAH KHAN; | 2020-04-20 |
| 406 | Reducing Hospital Admission of Elderly in SARS-CoV-2 Pandemic Via The Induction of Trained Immunity By Bacillus Calmette-Guérin Vaccination, A Randomized Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacillus Calmette-Guérin (BCG) vaccine not only protects against tuberculosis, but has also been shown to induce protection against various infections with a viral aetiology, leading to significant reductions in morbidity and mortality. We hypothesize that BCG vaccination might be a potent preventive measure against SARS-CoV-2 infection and/or may reduce disease severity in elderly people, who are known to be at increased risk of illness and death from SARS-CoV-2 infection. Therefore, … |
RADBOUD UNIVERSITY MEDICAL CENTER | 2020-04-16 |
| 407 | CITRUS Study (Comparing The Incidence Between Tiotropium and ICS/LABA in Real World Use in South Korea) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-interventional, Single-country study based on existing data from medical records of COPD patients treated with LAMA or fixed dose combination of ICS/LABA |
BOEHRINGER INGELHEIM | 2020-04-15 |
| 408 | Antegrade Observational Comparative Study for The Intravesical Instillation Therapy of Bacillus Calmette Guerin With The Use of Different Types of Urinary Catheters in Patients With Urinary Bladder Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study compares the complications caused after the BCG intravesical instillation in patients treated for non invasive bladder cancer.The patients are divided into two groups one receiving IVI (intravesical Instillations) with the use of latex catheter while in the other silicone catheter is used.The two groups are compared in terms of fever, hematuria, LUTS and other complications following IVI. |
BELLOS THEMISTOKLIS; | 2020-04-12 |
| 409 | Evaluating Newly Approved Drugs in Combination Regimens for Multidrug-Resistant TB With Fluoroquinolone Resistance (endTB-Q) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: endTB-Q Clinical Trial is a Phase III, randomized, controlled, open-label, non-inferiority, multi-country trial evaluating the efficacy and safety of two new, all-oral, shortened regimens for multidrug-resistant tuberculosis (MDR-TB) with fluoroquinolone resistance. |
LORENZO GUGLIELMETTI; | 2020-04-06 |
| 410 | Evaluation of New Biomarker-based Approaches for Improving The Diagnosis of Childhood Tuberculous Meningitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The rapid diagnosis of tuberculosis (TB) in children remains a serious challenge owing to limitations in the existing diagnostic tests. TB meningitis (TBM), an extrapulmonary form of TB, is the most severe manifestation of paediatric TB. TBM results in high morbidity and mortality in children, despite the availability of chemotherapy, mainly due to diagnostic delay. Most tests required for proper TBM diagnosis including analysis of cerebrospinal fluid (CSF) and brain imaging are not available in resource-limited settings e.g., … |
VINZEIGH LEUKES; | 2020-04-01 |
| 411 | Assessment of The Psycho-social Impact of COVID-19 Outbreak (COM-COVID) PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: It has been shown in previous important outbreaks of infectious diseases that they have a huge impact on individuals and communities. The psychological effects of the illness itself and the traumatic experiences of loved ones are experienced by individuals and complete health systems. Added to this, the social ecosystem and family finances are also severely affected. After several months of the outbreak start and several weeks of quarantine and self-isolation, the emotional burden on the community has increased. Added to this, many of the confirmed cases are healthcare workers. In addition to the risk of infection, … |
CRIS VILAPLANA; | 2020-03-31 |
| 412 | Reducing Health Care Workers Absenteeism in COVID-19 Pandemic By Enhanced Trained Immune Responses Through Bacillus Calmette-Guérin Vaccination, A Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Covid-19 spreads rapidly throughout the world. A large epidemic in the Netherlands would seriously challenge the available hospital capacity, and this would be augmented by absenteeism of healthcare workers (HCW). Strategies to prevent absenteeism of HCW are, therefore, desperately needed to safeguard continuous patient care. Bacille Calmette-Guérin (BCG) is a vaccine against tuberculosis, with protective non-specific effects against other respiratory tract infections in in vitro and in vivo studies, … |
MJM BONTEN; | 2020-03-25 |
| 413 | Double-Blind, Randomized, Placebo-Controlled Phase IIa Clinical Trial to Investigate The Safety and Immunogenicity of RUTI® Therapeutic Vaccination in Patients With MDR-TB After Successful Intensive-phase Treatment Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective, randomized, double-blind, multicentre, placebo-controlled clinical phase IIa trial to evaluate safety and immunogenicity of RUTI® vaccine in Multidrug-resistant Tuberculosis (MDR-TB) patients favourably responding to standard MDR-TB treatment. Time point of vaccination starts at 16 weeks upon start of standard MDR-TB treatment (cohort A), and if clinically safe as evaluated by an independent panel of experts (DSMB), another cohort of patients will be vaccinated at 2 weeks upon start of standard MDR-TB treatment (cohort B), All the patients will be followed up 8 weeks after vaccination. |
TJIP S VAN DER WERF; | 2020-03-18 |
| 414 | Impact of An Innovative Childhood TB Diagnostic Approach Decentralized to District Hospital and Primary Health Care Levels on Childhood Tuberculosis Case Detection and Management in High Tuberculosis Incidence Countries PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The TB-Speed Decentralisation study aims to increase childhood Tuberculosis (TB) case detection at district hospital (DH) and Primary health Care (PHC) levels using adapted and child-friendly specimen collection methods, i.e. Nasopharyngeal Aspirate (NPA) and stool samples, sensitive microbiological detection tests (Ultra) close to the point-of-care (Omni/G1(Edge)), reinforced training on clinical diagnosis, and standardized CXR quality and interpretation using digital radiography. The TB-Speed Decentralisation study will evaluate the impact of an innovative patient care level diagnostic approach deployed at DH and PHC levels, namely the DH focused and the PHC focused decentralization strategies. This is aimed at, … |
OLIVIER MARCY; | 2020-03-07 |
| 415 | A Pilot Study of Mobile Directly Observed Therapy (mDOT) for Immunosuppressant Adherence in Adolescent Kidney Transplant Recipients Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppression medication adherence among adolescent kidney transplant recipients. The investigators aim to test this by recruiting adolescent (ages 14-21) kidney transplant recipients to use an mHealth application to record themselves taking their immunosuppression medications, and tracking medication adherence over time. The study population will be approximately 50 adolescent kidney transplant recipients at the Johns Hopkins Hospital. |
MACEY L HENDERSON; | 2020-03-04 |
| 416 | Genotype-Informed Versus Empiric Management of VirEmia (GIVE MOVE) in HIV-Infected Children and Adolescents on Antiretroviral Therapy: An Open-Label Randomised Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: HIV infection can be effectively controlled with antiretroviral therapy (ART). However, children and adolescents living with HIV and receiving ART suffer high rates of treatment failure, predominantly caused by suboptimal adherence to therapy and/or viral drug resistance. While high-income countries routinely use genotypic resistance testing (GRT) to determine which drug combinations are likely to be effective, this diagnostic tool is relatively costly and labour-intensive and is not routinely available in most resource-limited settings. GIVE MOVE is a multi-country (Lesotho, … |
JENNIFER A BROWN; | 2020-03-03 |
| 417 | Endobronchial Ultrasound Transbronchial Needle Aspiration (EBUS-TBNA) Versus The Endobronchial Ultrasound Transbronchial Needle Biopsy Using The Acquire Needle in The Assessment of Mediastinal and Hilar Lymphadenopathy: A Randomised Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine whether a new type of needle used for sampling lymph nodes (glands) around the airways of the lung, during a procedure called an endobronchial ultrasound (EBUS, provides more or better quality tissue to allow a definite diagnosis to be made than with the current standard sampling needle. Two hundred and fifty patients will be randomised to procedures using either the new or standard needle, and the results compared. |
SAMUEL V KEMP; | 2020-03-02 |
| 418 | Empirical Treatment Against Cytomegalovirus and Tuberculosis in HIV-infected Infants With Severe Pneumonia: A Multicenter, Open-label Randomized Controlled Clinical Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial will evaluate whether empirical treatment against cytomegalovirus and tuberculosis improves survival of HIV-infected infants with severe pneumonia. |
HOSPITAL UNIVERSITARIO 12 DE OCTUBRE | 2020-03-01 |
| 419 | A Prospective, Randomized Controlled Study for The Efficacy and Safety of The Substitution of Pyrazinamide and Ethambutol With Moxifloxacin During The Intensive Phase of Treatment of Pulmonary Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to find an optimized initial regimen for pulmonary tuberculosis(PTB), evaluating the efficacy, safety and acceptability of isoniazid, rifampicin and moxifloxacin(HRM) for the intensive phase of initial therapy of PTB, compared with the standard initial regimen. |
LI DING; | 2020-03-01 |
| 420 | Phenotypic Personalized Medicine: Systematically Optimized Combination Therapy in Multiple Myeloma Using CURATE.AI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinical trial applying CURATE.AI, a Phenotypic Precision Medicine (PPM) platform, to Bortezomib, Thalidomide and Cyclophosphamide dosing in multiple myeloma patients to show improvement in response. |
WEE JOO CHNG; | 2020-03-01 |
| 421 | StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of pravastatin adjunctive therapy when combined with the standard tuberculosis (TB) treatment regimen in adults with TB. |
PETROS C. KARAKOUSIS; | 2020-02-21 |
| 422 | Evaluation of Stigma and Related Factors in Fibromyalgia Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Stigmatization is especially studied in mental disorders such as schizophrenia. In recent years, different chronic diseases such as AIDS, tuberculosis, and diabetes have also been shown to decrease in quality of life due to the stigma of these patients. |
MEHMET AKIF GÜLER; | 2020-02-13 |
| 423 | Simple Blind, Placebo Controlled, Randomized, Two-stage, Prospective, Single-center Safety, Tolerability and Reactogenicity Trial of The [Recombinant Tuberculosis Allergen in Standard Dilution], Solution for Intradermal Injection, 0.1 ML/Dose, Produced By FSUE SPbSRIVS FMBA of Russia, in Healthy Volunteers After A Single Dose in The Dilution of 0.1 Μg / 0.1 ML or 0.2 Μg / 0.1 ML PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary objective of the trial is to study the safety and tolerability of the Recombinant tuberculosis allergen in standard dilution in healthy volunteers after a single dose. Additional trial purpose: evaluation of the product reactogenicity. |
ST PETERSBURG RESEARCH INSTITUTE OF VACCINES AND SERA | 2020-02-13 |
| 424 | Switching Treatment-Experienced, Integrase Inhibitor-Naïve, Virally Suppressed HIV-1 Infected Adults From Ritonavir Boosted Protease Inhibitors to Dolutegravir: An Open-Label Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Kenya has the 4th largest HIV burden in the world with about 1.6 million people living with HIV. Of these, just over 1 million are on antiretroviral therapy (ART). Current national guidelines recommend a first line regimen composed of 2 nucleoside reverse transcriptase inhibitors (NRTI) plus an integrase strand transfer inhibitor (INSTI) or a non-nucleoside reverse transcriptase inhibitor(NNRTI). Second line regimens are composed of 2 NRTI plus a ritonavir boosted protease inhibitor(PIr). This is based on evidence showing good clinical outcomes on this regimen. PIr are associated with side effects including an increase in cardiovascular disease risk and, … |
LOICE ACHIENG; | 2020-02-12 |
| 425 | Randomized Trial of Pharmaceutical Care and Text Messaging Intervention to Improve Tuberculosis Care and Management Among Drug-susceptible Patients in Pakistan PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to standardize the management of Pharmaceutical care with the two-way text messages and incentive for mobile usage during the treatment for tuberculosis patients, to improve the outcomes and compliance, reduce the risk of transmission and to evaluate the patient perspective in terms of their quality of life, shared decision making and satisfaction with services provided. |
FARMAN ULLAH KHAN; | 2020-02-01 |
| 426 | Strategies to Increase Antenatal Iron and Folic Acid Supplementation and Malaria Prophylaxis in Rural South-central Côte D’Ivoire: Study Protocol of A Cluster Randomised Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Pregnancy increases the risk of malaria and nutritional deficiency. Despite some progress in ANC access over the past years, coverage of antenatal iron and folic acid supplementation (AIFAS) and intermittent preventive treatment of malaria in pregnancy (IPTp) remains low in many countries. The main objective of this research project is to identify the most effective ways to increase AIFAS and IPTp in low-income settings. We will assess the relative effectiveness of two strategies: the provision of information on the importance of AIFAS and IPTp for pregnant women (Intervention Arm I – demand side intervention), … |
SIAKA KONE; | 2020-02-01 |
| 427 | Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: PandrTB is a study of the pharmacokinetics(PK) and pharmacodynamics(PD) of bedaquiline, delamanid, clofazimine, linezolid, moxifloxacin, levofloxacin and pyrazinamide used in novel combinations to treat multidrug-resistant tuberculosis(MDR-TB). |
HELEN MARGARET MCILLERON; | 2020-01-30 |
| 428 | Case Control Study of Vitamin D Status and Adult Multidrug-resistant Pulmonary Tuberculosis in Maharashtra, India PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: India has the highest incidence of and mortality from multi-drug resistant tuberculosis (MDR-TB) globally. Vitamin D status may be an important determinant of MDR-TB infection and treatment outcomes; however, observational evidence is insufficient to support its use as an adjunct therapy or prophylaxis. Using a case-control design, this study will evaluate the relationship between vitamin D status and active MDR-TB disease among adult outpatient pulmonary MDR-TB cases, household contact controls, and matched controls from the general population (non-household controls) in Mumbai, … |
WAFAIE FAWZI; | 2020-01-27 |
| 429 | LILAC – TB : Lowering InterLeukin-1 Receptor Antagonist Concentrations After TB Treatment Onset : A Proof of Concept Study in Cambodia and Ivory Coast (ANRS 12394) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite marked improvements in the diagnosis of tuberculosis there are difficulties in diagnosing and monitoring treatment outcome among TB patients. The use of immunological biomarkers alone or in combination with other clinical parameters could predict early the response to TB treatment. The aim of this study is to demonstrate that the IL-1 receptor antagonist (IL-1Ra) concentrations significantly decrease within two weeks following TB treatment initiation in adults with active documented TB. |
LAURENCE WEISS; | 2020-01-21 |
| 430 | A Phase 2a, Dose Escalation, Controlled, Randomized Study to Evaluate Safety, Early Bactericidal Activity (EBA) and Pharmacokinetics of TBA-7371 in Adult Patients With Rifampicin-sensitive Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety, early bactericidal activity (EBA) and pharmacokinetics of TBA-7371 in adult participants with rifampicin-sensitive tuberculosis and select dose regimen(s) for future studies. |
BILL & MELINDA GATES MEDICAL RESEARCH INSTITUTE | 2020-01-16 |
| 431 | Multicentre Clinical Performance Evaluation of The Molbio Diagnostics Truenat™ HCV RNA Assay PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Molbio Diagnostics Ltd. (India) has developed the Truelab™ Real Time quantitative PCR system that is widely used in India for diagnostics of tuberculosis (TB). The system consists of two portable machines and two microfluidic cartridges and can be used in point-of-care settings. The manufacturer has recently developed a new assay that detects HCV RNA, the Truenat™ HCV RNA assay. It is a simple two-step assay for RNA extraction and amplification with a total turnaround time of 60 min, using whole blood, plasma and serum as sample types. Most importantly, … |
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS SWITZERLAND | 2020-01-12 |
| 432 | Cytometric Immunodiagnostics of Latent Tuberculosis Infection (LTBI) and The Influence of Previous BCG Vaccination – Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: TB-reactive immune cells will be tested in a multiparametric flow cytometry to distinguish an immune response for antigens of Mycobacterium spp. in TB disease/latent infection or a reaction after BCG vaccine. |
KAROLÍNA DOLEŽALOVÁ; | 2020-01-02 |
| 433 | Prevalence of Chronic Pulmonary Aspergillosis and Antifungal Drug Resistance of Aspergillus Spp. in Pulmonary Tuberculosis Patients in Uzbekistan PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary tuberculosis (PTB) is the most common cause of lung destruction, contributing to coinfections development, and Aspergillosis spp. is one of the most important. Diagnosis of chronic pulmonary aspergillosis (CPA) in PTB patients is difficult due to similarity of clinical and radiological data, … |
SVETLANA OSIPOVA; | 2020-01-01 |
| 434 | Standard Versus Double Dose Dolutegravir in Patients With HIV-associated Tuberculosis: A Phase 2 Non-comparative Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators propose to conduct a phase 2 randomised (1:1) double-blind placebo-controlled trial of the dolutegravir-lamivudine-tenofovir fixed dose combination tablet daily with an additional 50 mg dose of dolutegravir/matching placebo taken 12 hours later in ART-naïve or fisrt-line interrupted HIV-infected patients on rifampicin-based anti-tuberculosis therapy. The hypothesis is that virologic outcomes with standard dose dolutegravir-based ART will be acceptable in patients on rifampicin-based anti-tuberculosis therapy. |
GARY MAARTENS; | 2019-12-19 |
| 435 | Effect of Community Active Case Finding Strategies for Detection of Tuberculosis in Cambodia: Study Protocol for A Pragmatic Cluster Randomized Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is a highly stigmatized disease, and approximately one-third of the Cambodian population living with TB are undetected. Therefore, it is vital to find these missing cases and promptly link them to care to reduce disease progression and interrupt further transmission. The integration of community-based, peer-driven intervention in TB active case finding (ACF) is relatively novel. In partnership with KHANA, the National Center for Tuberculosis and Leprosy Control (CENAT), and the Cambodia Anti-Tuberculosis Association (CATA), we will conduct a pragmatic cluster randomized controlled trial comparing 1) the ACF with the seed-and-recruit model; 2) ACF targeting household and neighborhood contacts; … |
SIYAN YI; | 2019-12-16 |
| 436 | Prospective Multicentre Evaluation of The Accuracy and Diagnostic Yield of The Fujifilm SILVAMP TB LAM (FujiLAM) Test for The Diagnosis of Tuberculosis in People Living With HIV PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, multicentre cohort study in which the accuracy and the diagnostic yield of the FujiLAM test will be assessed using a microbiological reference standard, an extended microbiological reference standard and a composite reference standard among inpatient and outpatient people living with HIV (PLHIV). |
MORTEN RUHWALD; | 2019-12-13 |
| 437 | Clinical Evaluation of The Effectiveness and Safety of Resective Epilepsy Surgery for Tuberous Sclerosis Complex Related Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective controlled studies to identify clinical epilepsy control, cognitive changes, and safety in resective epilepsy surgery of tuberculosis-related epilepsy. |
SHULI LIANG; | 2019-12-12 |
| 438 | Clinical Evaluation of The Effectiveness and Safety of Vagus Nerve Stimulation for Tuberous Sclerosis Complex Related Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective controlled studies to identify clinical epilepsy control, cognitive changes, and safety in VNS treatment of tuberculosis-related epilepsy. |
SHULI LIANG; | 2019-12-10 |
| 439 | Performance Evaluation of The VIDAS TB-IGRA Assay PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the performance of the VIDAS® Interferon Gamma (IFN-γ) Release Assay (TB-IGRA) assay, which is intended for use as an aid in the diagnosis of tuberculosis infection. This study is designed to assess (1) the sensitivity of this assay, (2) its percent agreement with other diagnostic tests, (3) its measurement precision , and (4) any potential interference of the presence of other non-tuberculosis mycobacterial bacterial infections with this assay. |
DAVID PRIDE; | 2019-12-05 |
| 440 | The Effect of Rifampicin on The Pharmacokinetics of Intracellular Tenofovir-diphosphate and Tenofovir When Coadministered With Tenofovir Alafenamide Fumarate During The Maintenance Phase of Tuberculosis Treatment in TB/HIV-1 Coinfected Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pharmacokinetic study investigating the effect of rifampicin on the pharmacokinetics of intracellular tenofovir-diphosphate and plasma tenofovir when coadministered with tenofovir alafenamide fumarate during the maintenance phase of tuberculosis treatment in TB/HIV-1 coinfected participants (EpiTAF) |
FRANCOIS VENTER; | 2019-12-05 |
| 441 | Comparison of Regular Trigger Timing and Two Days Delay of Trigger in Ovarian Stimulations By GnRH Antagonist Protocol in in Vitro Fertilization PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The use of antagonist ovulation stimulation program is increasing year by year, because of its convenience, flexibility, and prevention effect of ovarian hyperstimulation syndrome. However, many researchers and clinicians believe that the clinical outcomes of antagonist regimens are worse than those of classical long-term regimens. Studies showed that the reasons for that maybe antagonist protocol results in poor effect on oocytes maturation or endometrial receptivity. At present, the trigger time of antagonist regimen is more than three follicles with diameters of ≥17 mm, … |
LI RONG; | 2019-12-01 |
| 442 | Patient Centered Intervention to Prevent Tuberculosis Among Children Under Five Years Old Who Are Household Contacts of Persons With Tuberculosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Isoniazid preventive therapy (IPT) reduces the risk of tuberculosis in 60%. Young children are at higher risk of developing severe forms of TB, though this can be prevented with a full course of IPT. Preliminary data indicate that 60% of eligible children start IPT, and 30% complete it. Furthermore, … |
LARISSA OTERO; | 2019-12-01 |
| 443 | A Prospective Phase Ib/IIa, Active-controlled, Randomized, Open-label Study to Evaluate The Safety, Tolerability, Extended Early Bactericidal Activity and Pharmacokinetics of Multiple Oral Doses of BTZ-043 Tablets in Subjects With Newly Diagnosed, Uncomplicated, Smear-positive, Drug-susceptible Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, open label, two-centre, randomized, controlled, two-stage, phase Ib/IIa study to evaluate the safety, tolerability, PK, drug-drug interaction and bactericidal activity of BTZ-043 administered orally once daily over 14 days to participants with newly diagnosed, uncomplicated, smear-positive, drug-susceptible pulmonary tuberculosis. The primary objective is to assess the safety and tolerability of BTZ-043 given over 14 days by evaluation of adverse events during treatment and follow-up period in patients with newly diagnosed, uncomplicated, smear-positive, drug-susceptible pulmonary tuberculosis. |
MICHAEL HOELSCHER; | 2019-11-15 |
| 444 | First in Human Study to Evaluate The Safety, Tolerability and Preliminary Efficacy of The Bispecific PSMAxCD3 Antibody CC-1 in Patients With Castration Resistant Prostate Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial is a first in human (FIH) study in patients with castration resistant metastatic prostate cancer (CRPC) after failure of third-line therapy aiming to evaluate safety and efficacy of CC-1, a bispecific antibody (bsAb) with PSMAxCD3 specificity developed within DKTK. CC-1 binds to human prostate-specific membrane antigen (PSMA) on prostate cancer cells as well as to tumor vessels of CRPC, … |
HELMUT R SALIH; | 2019-11-15 |
| 445 | Development of A Diagnostic Prediction Score for Tuberculosis in Hospitalized Children With Severe Acute Malnutrition PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: TB-Speed SAM is a multicentric, prospective diagnostic cohort study conducted in two countries with high and very high TB incidence (Uganda and Zambia). It aims at assessing several diagnostic tests that could result in the development of a score and algorithm for TB treatment decision in hospitalised children with severe acute malnutrition (SAM). |
OLIVIER MARCY; | 2019-11-04 |
| 446 | Modified Ross Score for Evaluation of Heart Failure in Children With Lower Respiratory Tract PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: – Identification of Patient those at risk For heart failure associated with lower respiratory tract infection – Assess the value of Ross score evaluation in lower respiratory tract infection complicated with HF, as a diagnostic tool for severity of HF |
ENAS SAAD HASSAN; | 2019-11-01 |
| 447 | Level of FeNO in Chinese Asthma Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the level of FeNO in Chinese asthma patients with respect to the different levels of asthma control over 1 year. |
FANNY W.S. KO; | 2019-10-15 |
| 448 | Community Intervention for Tuberculosis Active Contact Tracing and Preventive Therapy – A Cluster Randomized Study (CONTACT) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The many gaps observed in the cascade of care of tuberculosis (TB) child contacts occur mostly in the screening, preventive therapy (PT) initiation and PT completion steps and the main drivers of these gaps are considered to be the health system infrastructure, … |
MARYLINE BONNET; | 2019-10-14 |
| 449 | Point-of-care Strategies to Improve Tuberculosis Care Among Severely Immunosuppressed HIV-infected Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) remains the major cause of morbidity and mortality among patients with HIV. Sub-optimal diagnostics contributes towards poor patient outcome and there is an urgent need to identify non-sputum-based point-of-care diagnostic tests. The urine based lateral flow lipoarabinomannan TB diagnostic test (LF-LAM) is a simple, inexpensive point-of-care test. In 2015, the World Health Organization endorsed LF-LAM for conditional use among patients with advanced HIV, … |
JOHANNA MARIA ÅHSBERG; | 2019-10-14 |
| 450 | Phase I/II Dose Finding and Safety Study of Rifapentine and Isoniazid in HIV-Infected and HIV-Uninfected Children With Latent Tuberculosis Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypotheses: Rifapentine (given as water-dispersible monolayer and/or fixed dose combination with isoniazid) dosing in HIV-infected and uninfected children ≤ 12 years of age with latent TB infection (LTBI) or with exposure to Mycobacterium tuberculosis (M. tuberculosis) will require higher mg/kg rifapentine dosing than adults to achieve adult- exposures which are correlated with efficacy in trials of TB prevention. Investigators further hypothesize that rifapentine will be safe and well-tolerated in HIV-infected and uninfected children who require treatment for LTBI. |
ANNEKE HESSELING; | 2019-10-12 |
| 451 | Validation of A Tuberculosis Treatment Decision Algorithm in HIV-infected Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: TB-Speed HIV is a prospective multicentre management study evaluating the safety and feasibility of the recently proposed PAANTHER TB treatment decision algorithm for HIV-infected children with presumptive TB. It will be conducted in four countries with high and very high TB (Tuberculosis) incidence (Côte d’Ivoire, Uganda, Mozambique, and Zambia) which have not participated in the study that developed the PAANTHER algorithm. |
OLIVIER MARCY; | 2019-10-02 |
| 452 | Improving Rhode Island’s Tuberculosis Preventive Services in Primary Care: A Mixed-Methods Evaluation of An Innovative Telementoring Model PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study explores primary care team members’ knowledge, attitudinal, and skill gaps related to LTBI testing and treatment. The gaps identified will inform the design of a survey and telementoring educational program (TB infection ECHO course). The EMR data query will further explore the reach of the ECHO model. The hypothesis for this study is that the TB infection ECHO course will be feasible, will have a significant impact on primary care provider participants’ learning and performance related to LTBI testing and treatment in their primary care practices, … |
DARIA SZKWARKO; | 2019-10-02 |
| 453 | Proportion of Clinical Improvement and Score Comparison of Type 1 Interferon, Transcriptomic Analysis in Idiopathic Uveitis Patients With IGRA Positive Before and After Anti-Tuberculosis Drugs Treatment: Cohort Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine the proportion of clinical improvement, the score changing of type 1 interferon selected gene expression, and analysis of transcriptomics profiling in patients with idiopathic uveitis positive IGRA before and after receiving Anti-Tuberculosis Therapy (ATT). Hopefully, by conducting this research, … |
RINA LA DISTIA NORA; | 2019-10-01 |
| 454 | Causes of Fever of Unknown Origin (FUO) in Infants and Children Attending Assiut University Children Hospital (AUCH) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Definition: fever < 38˚c for which the cause could not be identified, documented by a health care provider after 3w.evaluation as an outpatient [or after 1w. evaluation in the hospital]. Most cases, however, do not have fever alone, but FUO results from atypical presentation of common diseases. On the other hand FUO lasting longer than 6mo is uncommon in children & suggests granulomatous, autoimmune or auto inflammatory diseases |
RANDA MOHAMMED ABD EL TWAB; | 2019-10-01 |
| 455 | Randomized Open-label Study of The Impact of Prolonged Systemic Corticosteroid Therapy on The Course and Relapse Risk of Checkpoint Inhibitor Interstitial Lung Disease (Pneumonitis) Related to The Treatment of Solid Tumors With Anti-programmed-death Type 1 Receptor or Ligand Antibodies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective interventional open-label randomized trial. The patients treated with anti- PD-1 (programmed-death receptor type 1) or anti-PD-L1 (programmed-death ligand) antibodies in case of new acute onset interstitial changes or new seriuos respiratory system related symptoms will be recruited for this study to perform diagnostics. At the recruitment the patient will be randomized 1:1 to investigatory or control arm, … |
MATEUSZ POLACZEK; | 2019-10-01 |
| 456 | 11 El-Saraya St. – Manial – Cairo PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present investigation is to assess the clinical therapeutic effect of topical use of Coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus and determine whether the effect, if any, was due to its antioxidant activity. |
MOSTAFA ABDELSAMIE BAKRY NAFIE; | 2019-10-01 |
| 457 | Optimization of Tuberculosis Diagnosis and Management Using Four Immunological Biomarkers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is the leading cause of death by infectious disease in the world, responsible for 1.6 million deaths in 2017. The treatment of active TB requires at least a 6-month combined antibiotic regimen and can cause heavy side effects. As a consequence, treatment adherence is not optimal, … |
FLORENCE ADER; | 2019-09-30 |
| 458 | Novel Triple-dose Tuberculosis Retreatment Regimens: How to Overcome Resistance Without Creating More Related Papers Related Patents Related Grants Related Experts View Highlight: Drug-resistance is a major challenge for tuberculosis (TB) care programs. The new WHO guideline recommends adding levofloxacin in previously treated patients with isoniazid-resistant rifampicin-susceptible TB. The investigators believe that such a retreatment regimen may result in acquired resistance to fluoroquinolone, the core drug of multidrug-resistant TB (MDR-TB) regimen, and thus threaten the effectiveness of the fluoroquinolone-based MDR-TB treatment regimen. Therefore the investigators propose to study if regimens strengthened by using high-dose first-line drugs, either a triple dose of isoniazid or a triple dose of rifampicin, … |
TOM DECROO; | 2019-09-30 |
| 459 | Comparing Incidence Rate of Systemic Drug Reactions Under 3HP and 1HP Regimen for Latent Tuberculosis Infection Treatment: A Pragmatic Multicenter Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Successful implement of preventive therapy for subjects with latent tuberculosis infection (LTBI) is the critical step for elimination of tuberculosis (TB). The major obstacle of traditional preventive therapy is the unacceptable long treatment duration, taking isoniazid 5mg/kg daily for a total of 9 months (9H), thus seriously compromising its acceptability. With the introduction of 12-doses weekly high-dose (15 mg/kg) rifapentine plus isoniazid (3HP regimen), the completion rate of 3HP has be shown to be much higher than 9H. However, 4.9% to 9.1% of LTBI cases who received 3HP failed to complete treatment because of side effects. Systemic drug reactions (SDRs), … |
JANN-YUAN WANG; | 2019-09-24 |
| 460 | Saliva and Dried Blood Spot Therapeutic Drug Monitoring for MDR-TB in Tanzania PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dried blood spot and saliva samples are collected during multidrug resistant tuberculosis (MDR-TB) treatment to measure the drug concentration of levofloxacin. Feasibility of both analytical procedures in a high burdened setting is explored. |
JAN-WILLEM C ALFFENAAR; | 2019-09-24 |
| 461 | Assessing The Ability of The T-SPOT®.TB Test to Identify Those at Risk of Active Mycobacterium Tuberculosis Infection Using The Normalized Tuberculosis (TB) Specific Lymphocyte Response PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this clinical research study is to demonstrate performance of the normalized TB specific lymphocyte response (NTBSLR) in identifying patients with active TB disease. The secondary exploratory objective is to demonstrate that active TB cannot be identified using an antigen-to-mitogen ratio derived from an ELISA-based IGRA. |
BLANCA RESTREPO; | 2019-09-23 |
| 462 | Prospective Evaluation of Novel Diagnostics for Tuberculosis in KwaZulu-Natal, South Africa PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) infects nearly two billion people and has become the leading infectious cause of mortality worldwide, due in part to inadequate diagnostic and prognostic tests. Older diagnostic tools, such as acid-fast staining, and newer diagnostic tests, such as nucleic acid amplification, are either insensitive, expensive, or not suitable for use at the clinical point-of-care. Therefore, novel diagnostic tests are needed to diagnose active TB disease among adults, people living with HIV (PLHIV), and children in TB-endemic countries. In this project, the investigators will conduct clinical evaluation studies of emerging TB diagnostic tests among (1) hospitalized adults, … |
PAUL DRAIN; | 2019-09-18 |
| 463 | A Study to Validate and Improve An Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear Slides PF:3 Related Papers Related Patents Related Grants Related Experts View Abstract: Sensitivity, specificity, and average analysis time were determined. An image database of >40,000 images was also created for internal use. … |
DIASCOPIC | 2019-09-15 |
| 464 | Randomized Controlled Trial of Vitamin D Supplementation on Improvement of Pneumonic Children at Tertiary Pediatric Hospital in Egypt PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In Egypt, according to UNICEF 2018, Acute Respiratory Tract Infection (ARTIs)was estimated to account for 11% and 19% of the under-five and post-neonatal mortalities respectively. Despite the well-recognized role of vitamin D in metabolism and homeostasis in the general population, there is now growing interest in its probable association with pneumonia. Globally, about 30% to 90% of Under-5 children experience vitamin D deficiency. This could vary among children, according to the socioeconomic, environmental and behavioral circumstances. Studies evaluating the association of 1,25 (OH)2D deficiency and the severity of respiratory tract infection, are rare and showed controversial findings. However, … |
CAIRO UNIVERSITY | 2019-09-09 |
| 465 | Delayed Diagnosis of Bacteriologically Positive Pulmonary Tuberculosis and Relative Optimized Suggestions in China PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to collect health-seeking pathways, sociodemographic characteristics and symptoms of 400 newly diagnosed patients with bacteriologically confirmed pulmonary tuberculosis(TB). |
WEN-HONG ZHANG; | 2019-09-08 |
| 466 | A Phase 3b, Multicenter, Interventional, Randomized, Placebo-controlled Study Investigating The Efficacy and Safety of Guselkumab for The Treatment of Palmoplantar-non-Pustular Psoriasis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of guselkumab for the treatment of palmoplantar psoriasis. |
JANSSEN CILAG | 2019-09-03 |
| 467 | Japan Post-Marketing Surveillance – Specified Drug Use-results Survey for Peficitinib to Assess Safety and Effectiveness in The Patients With Rheumatoid Arthritis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to investigate the safety and effectiveness in routine clinical practice and actual clinical setting for all patients with rheumatoid arthritis (RA) treated with peficitinib. |
ASTELLAS PHARMA | 2019-09-02 |
| 468 | IDENTIFICATION OF URINARY MICROBIOTE IN PATIENTS WITH DIAGNOSTIC-RELATED CYSTOSCOPY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Identify by culture the urinary microbiota of patients with bladder cancer (at the time of diagnosis) and controls.Identify by metagenomics the urinary microbiota of patients with bladder cancer (at the time of diagnosis) and controls. |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2019-09-01 |
| 469 | A Study of Pattern of Presentation of Pulmonary Tuberculosis Patients Undergoing Treatment at Assiut University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the investigator’s study is to detect the characteristics, pattern and outcome of pulmonary tuberculosis patients treated at Assiut University Hospital by collecting their demographic, clinical, laboratory and radiological data. |
MARWA HUSSIEN KILANY; | 2019-09-01 |
| 470 | Emergency Department Triage in A Resource Constrained Setting: Application of The World Health Organization Triage Scale in Regional Papua New Guinea PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Triage is an important component of emergency care (EC). It aims to sort patients based on the urgency of their condition such that the highest acuity patients are prioritised for assessment and treatment. Grounded in the ethical principles of equity and justice, triage is necessary whenever there is a mismatch between demand for EC and the availability of resources. Globally, … |
ROB MITCHELL; | 2019-08-30 |
| 471 | The Association of Vitamin D Supplementation With The Outcome in Critically Ill Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vitamin D deficiency is highly prevalent in critically ill adult and pediatric population that causes multiple adverse health outcomes including higher illness severity score, increased morbidity and mortality, multiple organ dysfunction, longer duration of Mechanical ventilation, longer duration of Oxygen therapy and increased length of stay (LOS) in PICU and hospital. Vitamin D deficiency is a modifiable risk factor that can be corrected with high dose of vitamin D supplementation to improve the clinical outcome. This study is designed to determine whether random vitamin D supplementation within dose limits improves clinical outcomes in critically ill children. |
MUSTAHSIN KHALIL; | 2019-08-29 |
| 472 | An Open Label, Randomized Controlled Trial to Establish The Efficacy and Safety of A Study Strategy Consisting of 6 Months of Bedaquiline (BDQ), Delamanid (DLM), and Linezolid (LNZ), With Levofloxacin (LVX) and Clofazimine (CFZ) Compared to The Current South African Standard of Care (Control Strategy) for 9 Months for The Treatment of Rifampicin Resistant Tuberculosis (RR-TB) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: BEAT Tuberculosis is a phase 3, open label, multi-centre, randomized controlled trial. The purpose of this trial is to compare the efficacy and safety of a Study Strategy consisting of 6 months of bedaquiline (BDQ), delamanid (DLM), and linezolid (LNZ), with levofloxacin (LVX) and clofazimine (CFZ) compared to the current South African Standard of Care (Control Strategy) for 9 months for the treatment of rifampicin resistant (RR-TB) Tuberculosis. |
FRANCESCA CONRADIE; | 2019-08-22 |
| 473 | Implementation for Tuberculosis Preventive Therapy Among Latent Tuberculosis Infection in HIV-infected Individuals Using Novel Regimen of Isoniazid/Rifapentine Daily (4 Weeks) Compared to Isoniazid/Rifapentine Weekly (12 Weeks) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators want to know if ultra-short, effective treatment for latent tuberculosis (TB) infection (LTBI) could dramatically reduce the global incidence of active TB or not. The investigators hypothesize that short-course (4-week) daily isoniazid/rifapentine (INH/RPT) (1HP) is not inferior to standard -course (12 weeks) INH/RPT weekly regimen (3HP) for the prevention of TB in human immunodeficiency virus (HIV)-infected individuals. |
ANCHALEE AVIHINGSANON; | 2019-08-15 |
| 474 | The Usability Testing of The IeHS (Integrated E-healthcare Services) Web-based Application in The Therapy Management of HIV and Tuberculosis in Indonesia: A Concurrent Nested Study Design PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Technology that has a particular focus on patients’ needs and ease-of-use and -access plays a significant role in the development of e-health and m-health. The proposed model of a secured mobile health application may promote patient’s self-management and enhances adherence in chronic therapy exactly as it is easy-to-use, reducing patient’s burden in accessing medication information and instructions, and providing the opportunity for direct communications with health providers in charge for each patient with access to mobile technologies. Consequently, … |
LUSIANA RUSDI IDRUS; | 2019-08-05 |
| 475 | Six Weeks of Daily Rifapentine Vs. A Comparator Arm of 12-16 Week Rifamycin-based Treatment of Latent M. Tuberculosis Infection: Assessment of Safety, Tolerability and Effectiveness PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is conducted to compare the safety and effectiveness of a novel short 6-week regimen of daily rifapentine (6wP, experimental arm) with a comparator arm of 12-16 weeks of rifamycin-based treatment (standard of care, control arm) of latent M. tuberculosis infection (LTBI). This trial is conducted among persons who are at increased risk of progression to tuberculosis (TB) and require treatment of LTBI. The study will be conducted in the United States, the United Kingdom, … |
CENTERS FOR DISEASE CONTROL AND PREVENTION | 2019-08-01 |
| 476 | Effect of Vitamin D3 Supplementation on Chronic Granulomatous Disease Patients With BCGosis/Itis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: When children with chronic granulomatous disease (CGD) got BCG infection the treatment would be a tough task. The goal of the proposed research is to observe weather vitamin D supplementation can help the CGD children get through this challenge. |
JINQIAO SUN; | 2019-08-01 |
| 477 | Effect of Drinking Water Chlorination on Child Survival in Rural Kenya PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to estimate the effect of community-wide provision of water treatment (chlorine) solution on all-cause child mortality and on infectious disease related child mortality. We will also examine effects on the following secondary outcomes: 7-day diarrhea prevalence, all-cause under-2 mortality, diarrheal disease related child mortality, school attendance, and school enrollment. In addition, and for a subsample of children, we will examine effects on motor development, emergent language and literacy, emergent math/numeracy, and socio-emotional development. |
AMY PICKERING; | 2019-07-26 |
| 478 | Tuberculosis- Learning The Impact of Nutrition PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed work is based on the finding that one-third of the world is infected with the bacteria Mycobacterium tuberculosis (Mtb) and only 10% of these individuals develop TB. The study aims to identify factors that drive progression to disease and study signals (markers of the immune response) that detect who will progress to active TB and why this happens. Armed with these markers, the study will address how malnutrition and worms alter this signal profile to cause active TB. The work will be conducted in India, where there are 2.8 million TB cases each year – … |
NATASHA HOCHBERG; | 2019-07-12 |
| 479 | Uptake, Effectiveness and Acceptability of Routine Screening of Pregnant Migrants for Latent Tuberculosis Infection in Antenatal Care: A Feasibility Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The UK has the second highest tuberculosis (TB) incidence in Western Europe. Most active cases occur in migrants due to reactivation of latent TB infection (LTBI) acquired abroad. Screening migrants for LTBI was recently introduced by Public Health England to reduce TB rates and transmission of infectious cases. Newham, which has one of the highest TB rates in London introduced the first large-scale LTBI screening programme for migrants, … |
HEINKE KUNST; | 2019-07-03 |
| 480 | Evaluation of Pharmacokinetics and Safety Tolerability of Higher Doses of Rifampicin in Children With Newly Diagnosed Uncomplicated Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis in children is a major public health problem and it contributes 10% of the total TB cases worldwide. TB treatment outcomes in children are challenged by insufficient consideration of the relationships between doses administered, concentrations achieved and eventual desirable and undesirable effects (pharmacodynamics) of TB drugs. Rifampicin is a pivotal TB drug and data from adults suggest that a much higher dose of rifampicin (35 mg/kg instead of 10 mg/kg), resulting in much higher rifampicin exposures in plasma, … |
KILIMANJARO CLINICAL RESEARCH INSTITUTE | 2019-07-01 |
| 481 | Efficacy of Risk-Targeted Video Based Directly on Observed Therapy for Latent TB Related Papers Related Patents Related Grants Related Experts View Highlight: Center for Disease Control (CDC) data reveal that after years of sustained decrease, the incidence of active tuberculosis (TB) disease in the US has plateaued. Most of the cases occur when Mycobacterium tuberculosis (Mtb) reactivates replication in people who have latent tuberculosis infection (LTBI). Only 5 to 10% of subjects with LTBI develop active TB Infection over their lifetime. Current US guidelines recommend treating everyone with LTBI to stop progression to active TB. As treatment is long, only about 45-55% of patients finish treatment overall, … |
SOUMYA CHATTERJEE; | 2019-06-30 |
| 482 | Evaluation of Xpert MTB/RIF Ultra in Stools and Urine to Improve Tuberculosis Diagnosis in Children PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) diagnosis in children is challenging in low and middle-income countries where access to TB culture and X-ray is limited. More than half cases of childhood TB remain undiagnosed every year. A delay in TB diagnosis can lead to an increase in preventable morbidity and mortality. This study aims to provide evidence on the diagnostic accuracy of Xpert MTB/RIF Ultra in stools and urine for TB diagnosis in children. |
LAURA MORETÓ PLANAS; | 2019-06-26 |
| 483 | Evaluating Point-of-care Ultrasound to Improve Tuberculosis Diagnosis in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diagnosis of tuberculosis (TB) in children is particularly challenging in low and middle-income countries (LMIC), and a high number of children remain undiagnosed and untreated. A delay in diagnosis can lead to an increase in preventable morbidity and mortality. Point-of-care ultrasound (POCUS) is a bedside, non-invasive, inexpensive imaging tool, and TB-focused POCUS has been used and validated for adults with HIV. This study aims to describe the TB-focused POCUS findings for children with presumptive TB aged between 6 months and 15 years old, and to stratify the results per HIV, … |
LAURA MORETO; | 2019-06-26 |
| 484 | Multicentre Study to Evaluate The Diagnostic Accuracy of A Stool Processing Kit Combined With Xpert MTB/RIF Ultra for Paediatric TB Diagnosis Using Microbiological Confirmation on Respiratory Samples As The Reference Standard PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, multicentre cohort study in which the accuracy and the diagnostic yield of the Stool Processing Kit (SPK) in combination with Xpert Ultra MTB/RIF (Ultra) on stool samples will be assessed using a microbiological reference standard and a composite reference standard among children with signs and symptoms of pulmonary tuberculosis. |
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS SWITZERLAND | 2019-06-19 |
| 485 | Phase IIA Trial of The Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid With or Without Aspirin, for HIV-associated Tuberculous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: LASER-TBM is a parallel group, randomized, multi-arm phase IIa trial evaluating the safety of increased dose rifampicin (RIF) plus linezolid (LZD), with or without aspirin (ASA), for the treatment of HIV-infected adults with tuberculous meningitis (TBM). The study will recruit 100 HIV-infected adults with TBM across four sites in South Africa. The primary endpoint is the occurrence of solicited treatment-related adverse events. Secondary endpoints include death and disability (including neurocognitive impairment), radiological outcomes, … |
ROBERT J WILKINSON; | 2019-06-12 |
| 486 | Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx MDR-TB) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable active tuberculosis (TB) during 96 weeks of follow-up among high-risk household contacts (HHCs) of adults with multidrug-resistant tuberculosis (MDR-TB) (index cases). High-risk HHCs are those with HIV or non-HIV immunosuppression, latent TB infection, and young children below the age of 5 years. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2019-06-03 |
| 487 | Economic Evaluation of An Online Screening Tool With Selective Follow-up Versus Periodic Health Screening By The Occupational Physician PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In Belgium, Periodic Health Screenings (PHS) are obliged by law for several occupations, including safety functions, jobs with heightened vigilance, work that involves physical, biological or chemical agents or tasks that are an ergonomic or mental burden. Scientifically it remains an open question whether these screenings guarantee the prevention of later health problems or problems with functioning at work. The objective of this study is to compare the cost-effectiveness of PHS with an online health screening tool with selective follow-up. In five Flemish hospitals, the employees eligible for PHS (exempting frequent exposure to ionizing radiation, preparation of cytostatics, … |
JEROEN LUYTEN; | 2019-06-01 |
| 488 | AIDS Defining Opportunistic Infections in Naive HIV Cases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: HIV patients are likely to suffer from opportunistic infections, in absence of highly active retroviral therapy. This happens due to lack of awareness of HIV status among patients or unresponsive to anti retroviral drugs. This study is for the prevalence of AIDS defining OIs among treatment naive HIV patients. |
RANJAN KUMAR SINGH; | 2019-06-01 |
| 489 | Video Directly Observed Therapy (VDOT) to Improve Medication Adherence Among Depression Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Due to the lack of human resources, it is impossible to monitor patients’ medication adherence objectively or in-person by observation like tuberculosis programs worldwide do. The feasibility and patient acceptance of the innovative video-based directly observed therapy (VDOT) approach for improving medication adherence among tuberculosis patients has been demonstrated through studies in the United States as well as internationally (7). Medication adherence among VDOT users has been found to be comparable to in-person directly observed treatment (91% vs 95%) among patients in New York (8). In this clinical research project, we will test the feasibility, … |
UCONN HEALTH | 2019-05-27 |
| 490 | The Role of Vitamin D, A, and Beta Carotene in Tuberculosis Patients With Vitamin D Receptor Gene Polymorphism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Recent studies showed that vitamin D and A has an effect in improving sputum conversion in tuberculosis. This study aims to find out the effect of vitamin D 1000 IU and A 6000 IU supplementation on Tuberculosis patients with vitamin D receptor gene polymorphism, who live in North Sumatera, Indonesia. This study is a randomized control clinical trial, with 48 tuberculosis patients with vitamin D receptor gene polymorphism which are TaqI and FokI participating, divided into two groups, each with 24 participants, which are treatment group (I) which receives nutritional counseling, vitamin D 1000 IU, vitamin A 6000 IU, … |
DINA KEUMALA SARI; | 2019-05-14 |
| 491 | Soy, Catfish, Anchovy, and Rice Supplementation Increases 25(OH)D Serum Levels in Tuberculosis Patients With Complications PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis patients that have complications (e.g., diabetes mellitus and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)) who live in tropical regions experience vitamin D deficiency, especially in North Sumatra, Indonesia. The presence of vitamin D receptor (VDR) polymorphism genes, TaqI and FokI, is one of the predisposing factors, as is high levels of inflammatory markers, also indicating disease progression and malnutrition. This study aims to assess the effect of 50 g of soy-catfish-anchovy-rice (SCAR) porridge per day for 14 days on 25(OH)D, calcium, … |
DINA KEUMALA SARI; | 2019-05-11 |
| 492 | Nyaditum Resae® (a Food Supplement) As A Co-adjuvant During First-line Treatment for Active Pulmonary Tuberculosis and Its Impact on The Gut Microbiota – A Pilot Double-blind Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This will be the first study to evaluate the use of Nyaditum resae® as a potential agent for reducing antibiotic-associated gut dysbiosis in patients with drug-susceptible TB, and potentially improving clinical and microbiological markers of outcome |
GRANT THERON; | 2019-05-10 |
| 493 | An Open-Label, Phase II Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination With Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pharmacokinetic (PK) study was to evaluate if a double dose (3 mg) of levonorgestrel (LNG) overcomes known drug-drug interactions (DDIs) with efavirenz (EFV)-based antiretroviral therapy (ART) or rifampicin (RIF)-containing tuberculosis (TB) therapy. The safety of double-dose (3.0 mg) LNG versus standard-dose (1.5 mg) was also compared. |
AIDS CLINICAL TRIALS GROUP | 2019-05-06 |
| 494 | Assessing The Ability of The T-SPOT®.TB Test to Identify Those at Risk of Active Mycobacterium Tuberculosis Infection Using The Normalized TB Specific Lymphocyte Response PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this clinical research study is to demonstrate performance of the normalized TB specific lymphocyte response in identifying patients with active TB disease. The secondary exploratory objective is to demonstrate that active TB cannot be identified using an antigen-to-mitogen ratio derived from an ELISA-based IGRA. |
KEERTAN DHEDA; | 2019-05-02 |
| 495 | Evaluation of CRISPR-based Test for The Rapid Identification of Mycobacterium Tuberculosis Complex in Pulmonary Tuberculosis Suspects PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational Mycobacterium tuberculosis (MTB) diagnostics evaluation study is a prospective study of pulmonary TB suspects who are undergoing sputum or bronchoalveolar lavage fluid (BALF) evaluation for pulmonary TB. The sensitivity and specificity of the CRISPR-based assay will be compared to clinical diagnosis, conventional culture methods and Xpert MTB/RIF assay on same batch specimens. |
WEN-HONG ZHANG; | 2019-05-01 |
| 496 | Isolation of Circulating Pulmonary Cells in COPD and Its Relationship With Clinical Relevant Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We have demonstrated for the very first time that it is possible to isolate CPCs (circulating pulmonary cells) in patients with COPD in a sample of 17 patients (with a recovery rate of nearly 40%) and none of 10 healthy, non- smokers controls with a patented method [provisional Spanish Patent Application (P201730724)], based on liquid biopsy methodology (Romero Palacios et at, submitted 2017), … |
ENRIQUE HERRERA VIEDMA; | 2019-05-01 |
| 497 | Combined Phone Based Video DOT and Mobile Payments for TB Treatment in Cambodia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project proposes to develop and pilot a novel smart phone-based intervention to improve tuberculosis (TB) treatment adherence in Cambodia, which integrates video-enabled Directly Observed Treatment (vDOT) with an automated rewards system that transfers mobile money and eventual phone ownership to compliant patients. The results will be of immediate relevance to Cambodia’s National TB Control Program (which is partnering with us), the major implementing field partner Operation ASHA (a leading TB-focused nonprofit organization), as well as other TB control programs seeking new alternatives to improving adherence, especially where traditional DOT may be infeasible or costly, … |
JOANNE S. YOONG; | 2019-05-01 |
| 498 | A Study Assessing The Utility of Low-dose Computed Tomography (LDCT) in Lung Cancer Screening in North India PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Lung cancer screening with low-dose computed tomography (LDCT) has been recently shown to result in a significant reduction in lung cancer-specific mortality. However, the utility of LDCT screening in developing countries with high incidence of tuberculosis has not been adequately studied. The investigators hypothesize that LDCT screening in tuberculosis endemic regions is likely to yield a large proportion of false-positive results, especially in the initial round of screening, posing a significant burden on the healthcare system. Herein, the investigators assess the utility of LDCT and its cost-effectiveness in India. |
NAVNEET SINGH; | 2019-05-01 |
| 499 | Conception and Validation of A Clinico-radiological Classification of Peritoneal Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Traditionally, peritoneal tuberculosis has been classified as wet-ascitic, dry-plastic type and fibrotic -fixed types. there is substantial overlap between these definitions and the clinical implication of the categorisation into the three patterns is unclear. The clinical presentation will be used to divide participants into 1) Abdominal distension dominant disease or 2) Pain Dominant and/or 3) Obstruction dominant peritoneal tuberculosis. The radiological findings between these groups will be compared if findings on radiology are discriminative of these three patterns of presentation. |
VISHAL SHARMA; | 2019-05-01 |
| 500 | A Single Escalating Dose Pilot Trial of Canakinumab (ILARIS®) Assessing Safety and Biomarker Changes in Boys With Duchenne Muscular Dystrophy Related Papers Related Patents Related Grants Related Experts View Highlight: Canakinumab is an anti-interleukin 1 beta (IL1β) antibody approved for use in young children with familial Mediterranean fever, systemic onset juvenile idiopathic arthritis and TNF-receptor associated periodic fever syndrome. This study is a pilot trial to investigate the effects of canakinumab on clinical safety and potential clinical efficacy as demonstrated by short-term changes in select serum biomarkers in a sample of young boys with DMD who are most likely to have high levels of muscle inflammation. Steroid naive DMD subjects aged greater than or equal to 2 years old to less than 6 years old will receive a single subcutaneous dose of canakinumab and undergo safety and serum biomarker monitoring for 30 days. The first 3 subjects will receive 2 mg/kg and if well tolerated, the second 3 subjects will receive 4 mg/kg. |
CHRISTOPHER SPURNEY; | 2019-05-01 |