Clinical Digest: A Comprehensive Review of Recent Merck Sharp & Dohme Patents
This compilation provides an overview of Merck Sharp & Dohme‘s latest patent inventions. Alongside these patents are potentially related patents, which may include work from Merck Sharp & Dohme or other entities exploring similar therapeutic areas. This resource aims to offer researchers, clinicians, investors, and the broader public insights into Merck Sharp & Dohme’s current research and development pipeline. By presenting patent details alongside related intellectual property (regardless of origin), this compilation facilitates a broader understanding of Merck Sharp & Dohme’s strategic focus and how it potentially compares to direct and indirect competitors in these therapeutic spaces. This information can be valuable for identifying emerging trends in drug development, assessing the commercial potential of specific research programs, and understanding the broader landscape of scientific contributions related to Merck Sharp & Dohme’s patent inventions. (Last updated on: 2025-05-22)
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TABLE 1: Clinical Digest: A Comprehensive Review of Recent Merck Sharp & Dohme Patents
| Title | Applicant/Assignee | Filing Date | Publish Date | Grant Date | |
|---|---|---|---|---|---|
| 1 | PEPTIDE CONJUGATE VACCINE COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALZHEIMER’S DISEASE Related Patents View Abstract: The invention provides compositions and methods for the treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient, such as Alzheimer’s Disease. Such … |
MERCK SHARP & DOHME | 2024-11-14 | 2025-05-22 | |
| 2 | CYCLIC PEPTIDE FOR TRAPPING INTERLEUKIN-1 BETA Related Patents View Abstract: Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X , X , X , R -R , R , R , R , A , A , and subscripts t and w are as herein … |
MERCK SHARP & DOHME | 2024-11-12 | 2025-05-15 | |
| 3 | RIPK1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula I … |
MERCK SHARP & DOHME | 2024-10-31 | 2025-05-15 | |
| 4 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS Related Patents View Abstract: Compounds of Formulae (I)-(VII) or their pharmaceutically acceptable salts can inhibit the G12C, G12D, G12V, and/or G13D mutants of Kirsten rat sarcoma (KRAS) protein and are … |
MERCK SHARP & DOHME | 2024-10-18 | 2025-05-01 | |
| 5 | DEVICES FOR USE AS BLOOD BRAIN BARRIER MODELS Related Patents View Abstract: In some embodiments, devices for use as blood-brain barrier models are disclosed. The devices may include either a hydrogel component that surrounds a channel formed between a … |
MERCK SHARP & DOHME; WILLIAM MARSH RICE UNIVERSITY | 2024-10-16 | 2025-05-01 | |
| 6 | NEWCASTLE DISEASE VIRUSES AND USES THEREOF Related Patents View Abstract: Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and … |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI; MEMORIAL SLOAN-KETTERING CANCER CENTER; MERCK SHARP & DOHME | 2024-06-07 | 2025-04-24 | |
| 7 | PLASMA KALLIKREIN INHIBITORS Related Patents View Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating … |
MERCK SHARP & DOHME | 2023-01-23 | 2025-03-27 | |
| 8 | METHODS FOR TREATING ACUTE MYELOID LEUKEMIA WITH ANTI-ILT3 ANTIBODIES Related Patents View Abstract: This disclosure relates to methods for treating cancer in a subject identified as having acute myeloid leukemia (AML), comprising administering an anti-ILT3 antigen binding … |
MERCK SHARP & DOHME | 2022-07-25 | 2025-03-27 | |
| 9 | PLATFORM FOR ANALYSIS OF HIGH-THROUGHPUT SEQUENCING DATA Related Patents View Abstract: A sequencing data analysis platform can process datasets that include a large number of sequence read. The reads are aligned to one or more reference genomes. Due to sequencing … |
MERCK SHARP & DOHME et. al. | 2024-09-16 | 2025-03-20 | |
| 10 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS Related Patents View Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na 1.8 channel activity and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2024-11-26 | 2025-03-13 | |
| 11 | MULTIPRODUCT RESIN REUSE (MRR) FOR THE DEVELOPMENT AND CLINICAL MANUFACTURE OF THERAPEUTIC PROTEINS Related Patents View Abstract: The present invention provides a method for multiproduct resin reuse (MRR) utilizing ionic exchange chromatography columns. The methods of the invention outline the cleaning steps … |
MERCK SHARP & DOHME | 2024-08-09 | 2025-03-13 | |
| 12 | METHODS FOR TREATMENT AND PROPHYLAXIS OF HIV AND AIDS Related Patents View Abstract: The present invention is directed to methods for inhibition of HIV reverse transcriptase, treatment of infection by HIV, prophylaxis of infection by HIV, and the treatment, … |
MERCK SHARP & DOHME | 2024-11-13 | 2025-03-06 | |
| 13 | STABLE FORMULATIONS OF ANTI-CTLA4 ANTIBODIES ALONE AND IN COMBINATION WITH PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable formulations comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4), … |
MERCK SHARP & DOHME | 2024-09-11 | 2025-03-06 | |
| 14 | METHODS FOR TREATING CANCER WITH SUBCUTANEOUS ADMINISTRATION OF ANTI-PD1 ANTIBODIES Related Patents View Abstract: The invention relates to methods for treating cancer in a patient comprising subcutaneously administering a PD-1 antagonist, e.g., an anti-PD-1 antibody, or antigen binding … |
MERCK SHARP & DOHME | 2022-04-04 | 2025-03-06 | |
| 15 | LYOSPHERE CRITICAL REAGENT KIT Related Patents View Abstract: The present invention provides lyophilized pellets of low concentrations of antibodies in the form of lyospheres. These lyospheres provide pre-measured antibody concentrations … |
MERCK SHARP & DOHME | 2024-11-13 | 2025-02-27 | |
| 16 | TREATMENT OF MIGRAINE Related Patents View Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present … |
ALLERGAN PHARMACEUTICALS INTERNATIONAL et. al. | 2024-11-12 | 2025-02-27 | |
| 17 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS Related Patents View Abstract: The present disclosure is directed to compounds of Formula I: and their use as anti-viral agents for inhibition of the replication of hRSV and hMPV and treatment and prophylaxis … |
MERCK SHARP & DOHME | 2024-08-15 | 2025-02-27 | |
| 18 | ANTI-TIGIT ANTIBODIES Related Patents View Abstract: The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease. … |
MERCK SHARP & DOHME | 2024-08-05 | 2025-02-27 | |
| 19 | ANTIMALARIAL AGENTS Related Patents View Abstract: Provided are methods of treating malaria comprising administration of compounds of Formula (I), or a pharmaceutically acceptable salt thereof, to a subject in need thereof, … |
MERCK SHARP & DOHME; WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH; MSD R&D | 2022-12-05 | 2025-02-27 | |
| 20 | A THERAPEUTIC COMBINATION COMPRISING A TIGIT ANTAGONIST, A PD-1 ANTAGONIST, AND LENVATINIB Related Patents View Abstract: Provided herein are methods of treating cancer, an infectious disease, or an infection, which comprise administering to a human patient in need thereof: (a) a TIGIT antagonist; … |
EISAI R&D MANAGEMENT et. al. | 2022-08-09 | 2025-02-27 | |
| 21 | SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF Related Patents View Abstract: Provided are novel Substituted Thiophene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R , R , R , R , and R are as defined herein, as well as … |
MERCK SHARP & DOHME | 2022-12-15 | 2025-02-20 | |
| 22 | MONOVALENT INTERLEUKIN 12 (IL-12) HETERODIMERIC FC PROTEINS Related Patents View Abstract: Monovalent IL-12 heterodimeric Fc proteins that display attenuated potency at the IL-12 receptor compared to wild-type IL-12 and have an extended half-life compared to wild-type … |
MERCK SHARP & DOHME | 2024-08-08 | 2025-02-13 | |
| 23 | PYRAZOLOPYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES Related Patents View Abstract: Provided are novel Pyrazolopyrimidine Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R , R , R , and R are as defined herein. Also provided are … |
MERCK SHARP & DOHME | 2022-12-13 | 2025-02-13 | |
| 24 | PROCESSES FOR THE FORMULATION OF PNEUMOCOCCAL POLYSACCHARIDES FOR CONJUGATION TO A CARRIER PROTEIN Related Patents View Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from to a carrier protein. These processes are serotype … |
MERCK SHARP & DOHME | 2024-10-25 | 2025-02-06 | |
| 25 | BIOMARKERS FOR PREDICTING ELIGIBILITY FOR AN ANTI-ILT4 AND ANTI-PD-1 COMBINATION THERAPY Related Patents View Abstract: Disclosed herein are biomarkers that correlate with responses to an anti-ILT4 and anti-PD-1 combination therapy. A biomarker that can differentiate responders from non-responders … |
MERCK SHARP & DOHME | 2022-12-15 | 2025-02-06 | |
| 26 | P53 PEPTIDOMIMETIC MACROCYCLES Related Patents View Abstract: Disclosed are p53 peptidomimetic macrocycles, each p53 peptidomimetic macrocycle comprising an i, i+4 olefin staple and a polypeptide tail covalently linked to the p53 … |
MERCK SHARP & DOHME et. al. | 2022-12-05 | 2025-02-06 | |
| 27 | BLOCKING AND NON-BLOCKING SINGLE DOMAIN ANTIBODIES AND USES THEREOF Related Patents View Abstract: The invention relates, in part, to single domain antibody constructs. In particular, the invention relates, in part, to single domain antibody constructs that include a … |
MERCK SHARP & DOHME | 2022-12-01 | 2025-01-30 | |
| 28 | C-TERMINAL EXTENDED P53 ACTIVATOR CROSSLINKED PEPTIDOMIMETIC MACROCYCLES AGAINST MDM2/MDMX Related Patents View Abstract: The crosslinked peptidomimetic macrocycles disclosed herein comprise an alkene or alkyne staple and a poly-amino acid C-terminal tail. These crosslinked peptidomimetic macrocycles … |
MERCK SHARP & DOHME; MSD INTERNATIONAL; AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH | 2022-11-23 | 2025-01-30 | |
| 29 | TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS Related Patents View Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without … |
MERCK SHARP & DOHME | 2024-07-05 | 2025-01-23 | |
| 30 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Related Patents View Abstract: The present invention relates to Compounds of Formula (I) and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising … |
MERCK SHARP & DOHME | 2022-11-28 | 2025-01-23 | |
| 31 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS Related Patents View Abstract: The present invention relates to monobactam compounds of Formula I: The present invention also relates to pharmaceutical compositions comprising a monobactam compound of … |
MERCK SHARP & DOHME | 2022-11-16 | 2025-01-16 | |
| 32 | FORMULATIONS OF ANTIVIRAL COMPOUNDS Related Patents View Abstract: The present disclosure is directed to pharmaceutical formulations comprising an amorphous inhibitor of hepatitis C virus NS5A. These pharmaceutical formulations may be prepared by … |
MERCK SHARP & DOHME | 2024-09-23 | 2025-01-09 | |
| 33 | SCALABLE CHROMATOGRAPHY PROCESS FOR PURIFICATION OF HUMAN CYTOMEGALOVIRUS Related Patents View Abstract: The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two … |
MERCK SHARP & DOHME | 2024-07-11 | 2025-01-09 | |
| 34 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof Related Patents View Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise … |
ALIGOS THERAPEUTICS et. al. | 2022-09-08 | 2025-01-09 | |
| 35 | METHODS FOR TREATING CANCER USING A COMBINATION OF A PD-1 ANTAGONIST, AN ILT4 ANTAGONIST, AND CHEMOTHERAPEUTIC AGENTS Related Patents View Abstract: Provided herein are methods of treating cancer (e.g., ovarian, mesothelioma, triple-negative breast cancer), which comprise administering to a human patient in need thereof: (a) a … |
MERCK SHARP & DOHME | 2022-07-18 | 2025-01-09 | |
| 36 | COMBINATION OF A PD-1 ANTAGONIST AND A VEGF-R/FGFR/RET TYROSINE KINASE INHIBITOR FOR TREATING CANCER Related Patents View Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a multi-RTK inhibitor, and the use of the combination … |
EISAI R&D MANAGEMENT et. al. | 2024-09-06 | 2025-01-02 | |
| 37 | COMBINATION THERAPIES FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER Related Patents View Abstract: The present disclosure relates to methods of treating a cellular proliferative disorder (e.g., cancer) comprising administering: wherein: Also disclosed are therapeutic … |
MERCK SHARP & DOHME; SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL | 2023-12-07 | 2025-01-02 | |
| 38 | COMBINATION THERAPIES FOR THE TREATMENT OF CANCER Related Patents View Abstract: The present disclosure relates to methods of treating a cellular proliferative disorder (e.g., cancer) comprising administering: wherein: … |
MERCK SHARP & DOHME; SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL | 2023-12-07 | 2025-01-02 | |
| 39 | AMPOULE FOR ORAL VACCINE ADMINISTRATION AND METHODS OF USE Related Patents View Abstract: An ampoule includes a body having a cavity for storing a medicament, a neck coupled to the body and defining a nozzle in communication with the cavity of the body, a removable cap … |
MERCK SHARP & DOHME | 2022-11-11 | 2025-01-02 | |
| 40 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS Related Patents View Abstract: The present disclosure relates to compounds of formula (I) that are useful as modulators of a7 nAChR, compositions comprising such compounds, and the use of such compounds for … |
MERCK SHARP & DOHME | 2022-09-19 | 2025-01-02 | |
| 41 | COMPOSITIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF OBTAINING THE COMPOSITIONS THEREOF Related Patents View Abstract: The invention provides compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0% oxidation of Met105 in the CDRH3 heavy chain … |
MERCK SHARP & DOHME | 2024-09-06 | 2024-12-26 | |
| 42 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A TETRA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES Related Patents View Abstract: An insulin conjugate comprising or consisting of a tetra-valent sugar cluster is described. The tetra-valent sugar cluster is provided by tetra-dentate linker having four arms, … |
MERCK SHARP & DOHME | 2022-11-16 | 2024-12-26 | |
| 43 | VIAL-TO-SYRINGE CONVERTER AND METHODS OF MAKING AND USING SAME Related Patents View Abstract: In some examples, a vial-to-syringe converter includes a plunger rod, an adapter including a body having a piercing spike, a receiver and a lumen extending between the spike and … |
MERCK SHARP & DOHME | 2022-11-01 | 2024-12-26 | |
| 44 | SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF Related Patents View Abstract: Described herein are compounds of Formula I; and pharmaceutically acceptable salts thereof, wherein A, X, R , R , m, n, and p are as defined herein. The compounds of Formula I, … |
MERCK SHARP & DOHME | 2022-10-24 | 2024-12-26 | |
| 45 | MICRONEEDLE INJECTOR AND METHODS OF MAKING AND USING SAME Related Patents View Abstract: In some examples, an injector includes a base, a housing movable relative to the base, a needle unit disposed within the base, the needle unit comprising at least one piercing … |
MERCK SHARP & DOHME | 2022-11-01 | 2024-12-19 | |
| 46 | NANOEMULSION ADJUVANT COMPOSITIONS FOR HUMAN PAPILLOMAVIRUS VACCINES Related Patents View Abstract: The present disclosure provides, among other things, a vaccine composition that includes a squalene nanoemulsion (SNE) adjuvant and HPV virus-like particles (VLPs) of at least one … |
MERCK SHARP & DOHME | 2024-06-06 | 2024-12-12 | |
| 47 | BENZOXAZINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS Related Patents View Abstract: The present disclosure is directed to benzoxazinone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant … |
MERCK SHARP & DOHME | 2022-10-10 | 2024-12-12 | |
| 48 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2024-08-22 | 2024-12-05 | |
| 49 | 5,6 UNSATURATED BICYCLIC HETEROCYLES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 Related Patents View Abstract: Novel compounds of the structural formula (I), and pharmaceutically acceptable salts, hydrates and solvates thereof, are inhibitors of NLRP3 and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2024-05-30 | 2024-12-05 | |
| 50 | TRICYCLIC SULFAMIDES AND SULTAMS Related Patents View Abstract: Compounds of formula I, that modulate DCAF15 and induce RBM139 protein degradation, pharmaceutical compositions containing these compounds, and methods of using these compounds … |
MERCK SHARP & DOHME | 2022-10-07 | 2024-12-05 | |
| 51 | C-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, wherein R , R , and R are as … |
MERCK SHARP & DOHME | 2022-09-26 | 2024-12-05 | |
| 52 | COMPOUNDS AND ADJUVANT FORMULATIONS USEFUL IN PNEUMOCOCCAL VACCINES Related Patents View Abstract: The invention relates to novel compounds and formulations. Further, the invention relates to novel compounds and formulations useful in pneumococcal and pneumococcal conjugate … |
MERCK SHARP & DOHME | 2024-05-16 | 2024-11-28 | |
| 53 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2024-08-02 | 2024-11-21 | |
| 54 | POLYNUCLEOTIDES ENCODING NOROVIRUS VP1 ANTIGENS AND USES THEREOF Related Patents View Abstract: The present invention is directed to nucleic acids and related immunogenic polypeptides for the prevention or treatment of infectious diseases. In particular, the nucleic acids … |
MERCK SHARP & DOHME | 2024-05-06 | 2024-11-14 | |
| 55 | STREPTOCOCCUS PNEUMONIAE SEROTYPE SPECIFIC PCR PAD ASSAY Related Patents View Abstract: The invention described herein relates to a high-throughput and multiplex ( ) serotype (ST)-specific polymerase chain reaction-pneumococcal antigen detection (PCR-PAD) assay … |
MERCK SHARP & DOHME | 2024-04-23 | 2024-11-14 | |
| 56 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS Related Patents View Abstract: The present disclosure relates to compounds of formula I that are useful as modulators of α 7 nAChR, compositions comprising such compounds, and the use of such compounds for … |
MERCK SHARP & DOHME | 2022-09-19 | 2024-11-07 | |
| 57 | TROP2 BINDERS AND CONJUGATES THEREOF Related Patents View Abstract: TROP2 binders and variants thereof are described. In a specific embodiment, the TROP2 binders that are antibodies that preferentially bind high-expressing TROP2 cells over … |
MERCK SHARP & DOHME | 2024-04-22 | 2024-10-31 | |
| 58 | EVALUATING PRODUCTION BATCHES USING MACHINE-LEARNING Related Patents View Abstract: A method or a system for automated product inspection. The system receives multiple images of products captured from various perspectives. For each image, a machine-learning model … |
MERCK SHARP & DOHME et. al. | 2024-04-18 | 2024-10-24 | |
| 59 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof Related Patents View Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise … |
ALIGOS THERAPEUTICS et. al. | 2024-03-07 | 2024-10-24 | |
| 60 | SYRINGES AND INJECTORS WITH CAPACITIVE SENSING LOCKS AND METHODS OF MAKING AND USING SAME Related Patents View Abstract: An injecting device comprises a reservoir for containing a medicament, a needle in communication with the reservoir and configured to deliver the medicament to a patient’s body, a … |
MERCK SHARP & DOHME | 2022-09-07 | 2024-10-24 | |
| 61 | METHODS FOR MAKING POLYSACCHARIDE-PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by … |
MERCK SHARP & DOHME | 2024-06-28 | 2024-10-17 | |
| 62 | METHOD FOR ANALYZING TRACE LEVELS OF SEMI-VOLATILE NITROSAMINES IN SOLID SAMPLES Related Patents View Abstract: This invention describes a novel method encompassing preparing a nitrosamine sample. adding in relevant chemicals that reduces or eliminates in situ nitrosamine formation, … |
MERCK SHARP & DOHME | 2022-07-11 | 2024-10-17 | |
| 63 | STREPTOCOCCUS PNEUMONIAE SEROTYPE-SPECIFIC DETECTION ASSAY, REAGENTS AND KITS Related Patents View Abstract: is a major cause of community-acquired pneumonia (CAP) in young children, older adults, and those with conditions or medications that compromise their immunity. Since the … |
MERCK SHARP & DOHME | 2024-04-03 | 2024-10-10 | |
| 64 | IL4I1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein R , R , A, and B are as defined herein. The compounds of Formula I act as IL4I1 … |
MERCK SHARP & DOHME | 2024-03-27 | 2024-10-10 | |
| 65 | SOLID-PHASE GLYCAN REMODELING OF GLYCOPROTEINS Related Patents View Abstract: A solid-phase glycan remodeling (SPGR) system for the glycoengineering of glycoproteins to provide glycoprotein compositions comprising particular predominant glycoforms is … |
MERCK SHARP & DOHME | 2022-04-11 | 2024-10-10 | |
| 66 | PREPARATION OF OXINDOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS Related Patents View Abstract: Invented are compounds of formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making … |
MERCK SHARP & DOHME | 2024-05-23 | 2024-10-03 | |
| 67 | ORGANOID MICROINJECTION SYSTEM AND APPARATUS Related Patents View Abstract: A microinjection system and apparatus comprising stationary trough chips having wells and troughs to allow for efficient organoid microinjections are described. … |
MERCK SHARP & DOHME | 2022-09-07 | 2024-10-03 | |
| 68 | DOSAGE REGIMEN FOR ADMINISTRATION OF BELZUTIFAN Related Patents View Abstract: The present disclosure provides a method of treating cancer or von Hippel-Lindau (VHL) disease with a safe and effective therapeutic dose of belzutifan in a patient in need … |
MERCK SHARP & DOHME | 2022-08-08 | 2024-10-03 | |
| 69 | ANTIBODIES THAT BIND METAPNEUMOVIRUS, ANTIGENIC METAPNEUMOVIRUS PROTEINS, AND USES THEREOF Related Patents View Abstract: The present invention relates to anti-human metapneumovirus (hMPV) antibodies, as well as use of such antibodies in the treatment of viral infections. The invention also includes … |
MERCK SHARP & DOHME | 2022-02-08 | 2024-10-03 | |
| 70 | METHODS FOR TREATING CANCER WITH ANTI-ILT3 ANTIBODIES Related Patents View Abstract: This disclosure relates to methods for treating solid tumors in a patient identified as having metastatic triple negative breast cancer, glioblastoma, metastatic pancreatic ductal … |
MERCK SHARP & DOHME | 2022-03-17 | 2024-09-26 | |
| 71 | IL-2 MUTEINS FOR TREATING CANCER OR INFECTION Related Patents View Abstract: Provided herein are IL-2 muteins that bind to the IL-2 receptor β subunit but do not have measurable binding to the IL-2 receptor a subunit. Also provided are compositions, kits, … |
MERCK SHARP & DOHME | 2022-07-21 | 2024-09-19 | |
| 72 | HETEROARYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, R , R , and R are as … |
MERCK SHARP & DOHME | 2022-03-14 | 2024-09-19 | |
| 73 | ENZYMATIC SYNTHESIS OF 4′-ETHYNYL NUCLEOSIDE ANALOGS Related Patents View Abstract: The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on … |
MERCK SHARP & DOHME | 2024-05-28 | 2024-09-12 | |
| 74 | PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES Related Patents View Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and … |
MERCK SHARP & DOHME | 2024-04-29 | 2024-09-12 | |
| 75 | PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES Citation: 1 Related Patents View Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and … |
MERCK SHARP & DOHME | 2023-11-14 | 2024-09-12 | |
| 76 | ANTI-FOLR1 IMMUNOCONJUGATES AND ANTI-PD-1 ANTIBODY COMBINATIONS Related Patents View Abstract: Therapeutic combinations of immunoconjugates that bind to FOLR1 (e.g., IMGN853) with anti-PD-1 antibodies or antigen-binding fragments thereof (e.g., pembrolizumab) are provided. … |
IMMUNOGEN; MERCK SHARP & DOHME | 2023-10-18 | 2024-09-12 | |
| 77 | Static Multiomic Seed Approach for Identifying Molecular Signatures Related Patents View Abstract: Disclosed is a method for obtaining a dataset containing data values for a plurality of parameters corresponding to biological factors. Seed features that are known to be … |
MERCK SHARP & DOHME | 2023-03-07 | 2024-09-12 | |
| 78 | IDENTIFYING BIOSYNTHETIC GENE CLUSTERS Related Patents View Abstract: A biosynthetic gene cluster (BGC) prediction system identifies candidate BGCs within genomes using an iteratively trained machine-learned model. The system identifies, in a genome … |
MERCK SHARP & DOHME et. al. | 2024-05-03 | 2024-08-29 | |
| 79 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY Related Patents View Abstract: Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, … |
MERCK SHARP & DOHME | 2024-02-01 | 2024-08-29 | |
| 80 | PRODRUGS OF 4′-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS Related Patents View Abstract: The present invention is directed to prodrugs of compound A: which are nucleoside reverse transcriptase translocation inhibitors (NRTTI) and are useful in the inhibition of HIV … |
MERCK SHARP & DOHME | 2024-01-26 | 2024-08-29 | |
| 81 | IL4I1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof wherein A, E, U, X, Y, Z, R , R and n are as defined herein. The compounds of Formula I … |
MERCK SHARP & DOHME | 2022-06-23 | 2024-08-29 | |
| 82 | METHODS FOR PRODUCING STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDE CARRIER PROTEIN CONJUGATES Related Patents View Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal … |
MERCK SHARP & DOHME | 2024-04-17 | 2024-08-08 | |
| 83 | SOLID DOSAGE FORMULATIONS OF AN OREXIN RECEPTOR ANTAGONIST Related Patents View Abstract: The present invention is directed to a pharmaceutical composition comprising the compound suvorexant, or a pharmaceutically acceptable salt thereof, a concentration-enhancing … |
MERCK SHARP & DOHME | 2024-04-09 | 2024-08-08 | |
| 84 | SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF Related Patents View Abstract: The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt … |
MERCK SHARP & DOHME | 2022-05-26 | 2024-08-08 | |
| 85 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT Citation: 2 Related Patents View Abstract: Compounds of Formula (I) or (Ia) or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as … |
MERCK SHARP & DOHME | 2022-04-27 | 2024-08-08 | |
| 86 | PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE 0-ACYLTRANSFERASE 2 INHIBITORS Related Patents View Abstract: Provided are compounds of Formula I, Formula Ia and Formula Ib and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided … |
MERCK SHARP & DOHME | 2023-11-30 | 2024-08-01 | |
| 87 | CYCLOHEXYLGYCINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS Related Patents View Abstract: The present disclosure is directed to cyclohexylglycine derivatives of Formula I and their use as HIV-infected cell kill agents which accelerate the death of HIV GAG-POL … |
MERCK SHARP & DOHME | 2022-12-22 | 2024-08-01 | |
| 88 | FUNCTIONAL CELL-BASED POTENCY ASSAY FOR MEASURING BIOLOGICAL ACTIVITY OF INTERLEUKIN 2 (IL-2) ANALOGS Related Patents View Abstract: A functional cell-based potency assay for measuring the biological activity of IL-2 mutants with biased activity for the IL-2 receptor beta-gamma complex is described. In … |
MERCK SHARP & DOHME | 2022-06-02 | 2024-08-01 | |
| 89 | ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS Related Patents View Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the … |
MERCK SHARP & DOHME | 2024-04-09 | 2024-07-25 | |
| 90 | TRANSAMINASE ENZYMES FOR THE TRANSAMINATION OF (1S,5R)-6,8-DIOXABICYCLO[3.2.1]OCTAN-4-ONE Related Patents View Abstract: The present disclosure provides transaminase enzymes having improved properties and are capable of reducing (1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one with high selectivity. Also … |
MERCK SHARP & DOHME | 2022-05-26 | 2024-07-25 | |
| 91 | METHODS OF TREATMENT OF CANCER PATIENTS HAVING ALTERED SETD2 BIOMARKER WITH A PD-1 ANTAGONIST Related Patents View Abstract: The present disclosure describes methods of treatment of cancer in patients with altered activity or amount of a SETD2 biomarker with a treatment regimen comprising an antagonist … |
MERCK SHARP & DOHME | 2022-05-16 | 2024-07-25 | |
| 92 | ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS Related Patents View Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2022-05-02 | 2024-07-25 | |
| 93 | IL4I1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: The invention discloses a synthesizing method of benzimidazole derivant and intermediate, which is characterized by the following: proceeding arylation among aryl halide and … |
MERCK SHARP & DOHME; MSD R&D | 2022-04-28 | 2024-07-25 | |
| 94 | SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT Citation: 2 Related Patents View Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for … |
MERCK SHARP & DOHME | 2022-04-27 | 2024-07-25 | |
| 95 | SOLUTION FORMULATIONS OF ENGINEERED ANTI-IL-23p19 ANTIBODIES Related Patents View Abstract: The present invention provides high concentration solution formulations of anti-human interleukin-23 p19 (IL-23p19) antibody hum1388-b, and their use in treating various disorders. … |
MERCK SHARP & DOHME | 2024-01-05 | 2024-07-18 | |
| 96 | COMPOUNDS FOR TREATING CONDITIONS RELATED TO PCSK9 ACTIVITY Related Patents View Abstract: The present disclosure provides a method of treating hypercholesterolemia and other conditions related to PCSK9 activity, e.g. atherosclerosis, atherosclerotic cardiovascular … |
MERCK SHARP & DOHME | 2022-08-18 | 2024-07-18 | |
| 97 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT Citation: 2 Related Patents View Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for … |
MERCK SHARP & DOHME | 2022-04-15 | 2024-07-18 | |
| 98 | ANTI-ILT4 ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS Related Patents View Abstract: The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an … |
MERCK SHARP & DOHME; AGENUS | 2023-12-20 | 2024-07-11 | |
| 99 | COMBINATION THERAPIES FOR TREATING CANCER Related Patents View Abstract: The present invention provides methods of treatment for recurrent cancer(s) through combination therapy with an agent that inhibits programmed death-1 protein (PD-1) signaling and … |
TESARO; MERCK SHARP & DOHME | 2023-12-15 | 2024-07-11 | |
| 100 | PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION Related Patents View Abstract: The present invention provides a compound of Formula I wherein R , R , R , R , R , R , R , and subscripts x and n are as described herein and pharmaceutical compositions … |
MERCK SHARP & DOHME | 2023-11-20 | 2024-07-11 | |
| 101 | ROBOT TASK SCHEDULER WITH VERIFIED AUDIT TRAIL Related Patents View Abstract: A GUI is used to schedule a set of tasks for one or more robots to test samples using one or more instruments. A set of drivers are used to map instructions for the robots and … |
MERCK SHARP & DOHME | 2023-10-20 | 2024-07-11 | |
| 102 | BLOW-FILL SEALING METHOD FOR FILLING AND PACKAGING Citation: 1 Related Patents View Abstract: A method of controlling a temperature of a biopharmaceutical product during blow-fill sealing, includes developing a model based on heat transfer mechanisms that incorporates the … |
MERCK SHARP & DOHME | 2023-10-11 | 2024-07-11 | |
| 103 | RIPK1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula II, or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as RIPK1 inhibitors and can be useful in preventing, … |
MERCK SHARP & DOHME | 2022-04-21 | 2024-07-11 | |
| 104 | NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS Related Patents View Abstract: Novel forms of 2-amino-9-[(2R,5R,7R,8S,10R,12aR, … |
MERCK SHARP & DOHME | 2022-04-18 | 2024-07-04 | |
| 105 | AURISTATIN LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present disclosure is directed to linker-payloads, and pharmaceutically acceptable salts, solvates, or stereoisomer thereof, comprising a structure of formula I: The … |
MERCK SHARP & DOHME | 2023-12-12 | 2024-06-27 | |
| 106 | EXATECAN-DERIVED ADC LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present disclosure is directed to linker-payloads, and salts (including pharmaceutically acceptable salts), solvates, or stereoisomers thereof, comprising a structure of … |
MERCK SHARP & DOHME | 2023-10-23 | 2024-06-27 | |
| 107 | PHENYL AZEPINES AS RIPK1 INHIBITORS AND METHODS OF USE THEREOF Related Patents View Abstract: Described herein are compounds of Formula I: (I), or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as RIPK1 inhibitors and can be useful in … |
MERCK SHARP & DOHME | 2022-04-21 | 2024-06-27 | |
| 108 | PLASMA KALLIKREIN INHIBITORS Related Patents View Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or … |
MERCK SHARP & DOHME | 2022-04-18 | 2024-06-27 | |
| 109 | CONVOLUTIONAL NEURAL NETWORK FOR SUBVISIBLE PARTICULATE CLASSIFICATION OF BIOPHARMACEUTICALS Related Patents View Abstract: An analysis system implements a particulate classification model trained as a convolutional neural network to assess sterile formulation quality. The system obtains micro flow … |
MERCK SHARP & DOHME | 2023-12-20 | 2024-06-20 | |
| 110 | ROTAVIRUS VECTORS FOR HETEROLOGOUS GENE DELIVERY Related Patents View Abstract: Rotavirus vectors encoding in their genome a heterologous gene, and nucleic acid constructs encoding such rotavirus vectors. The rotavirus vector genome may include a rotavirus … |
MERCK SHARP & DOHME | 2022-04-11 | 2024-06-20 | |
| 111 | SYNTHESIS OF FLUORINATED CYCLIC DINUCLEOTIDES Related Patents View Abstract: The present invention relates to efficient processes useful in the preparation of fluorinated cyclic dinucleosides, such as … |
MERCK SHARP & DOHME | 2022-03-28 | 2024-06-20 | |
| 112 | PLASMA KALLIKREIN INHIBITORS Related Patents View Abstract: The present invention provides a compound of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or … |
MERCK SHARP & DOHME | 2022-03-16 | 2024-06-13 | |
| 113 | STABLE FORMULATIONS OF ANTI-TIGIT ANTIBODIES ALONE AND IN COMBINATION WITH PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The present invention relates to stable formulations of antibodies against T cell immunoreceptor with Ig and ITIM domains (TIGIT), optionally further containing an anti-human … |
MERCK SHARP & DOHME | 2024-01-25 | 2024-06-06 | |
| 114 | NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS Related Patents View Abstract: Novel forms of … |
MERCK SHARP & DOHME | 2022-04-04 | 2024-06-06 | |
| 115 | 3D SEGMENTATION OF LESIONS IN CT IMAGES USING SELF-SUPERVISED PRETRAINING WITH AUGMENTATION Related Patents View Abstract: A method or system for training a convolutional neural network (CNN) for medical imaging analysis. The system pre-trains the CNN’s encoder using a dataset of unlabeled 3D medical … |
MERCK SHARP & DOHME | 2023-11-28 | 2024-05-30 | |
| 116 | HETEROAROYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present invention is directed to certain (hetero)aroyl 4-aminopyrazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, R , R , and R are … |
MERCK SHARP & DOHME | 2022-03-14 | 2024-05-30 | |
| 117 | PRO DRUGS OF PDE10 COMPOUNDS Related Patents View Abstract: The present invention is directed to pro drugs of 2-methyl-N-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-6-((( S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-4-amine … |
MERCK SHARP & DOHME | 2023-12-13 | 2024-05-16 | |
| 118 | MULTI-DIMENSION UNIFIED SWIN TRANSFORMER FOR LESION SEGMENTATION Related Patents View Abstract: A system and method of multi-stage training of a transformer-based machine-learning model. The system performs at least two stages of the following three stages of training: … |
MERCK SHARP & DOHME | 2023-11-07 | 2024-05-16 | |
| 119 | REDUCING HIGH MANNOSE GLYCAN PROTEIN EXPRESSION USING GUANOSINE 5′-MONOPHOSPHATE Related Patents View Abstract: The present invention provides a method of reducing a high mannose glycan (HMG) content of a protein (e.g., monoclonal antibody) expressed during a mammalian cell culture (e.g., … |
MERCK SHARP & DOHME | 2022-03-03 | 2024-05-16 | |
| 120 | COMPOSITIONS AND METHODS FOR TREATING CANCER WITH SUBCUTANEOUS ADMINISTRATION OF ANTI-PD1 ANTIBODIES Related Patents View Abstract: The invention relates to compositions and methods for treating cancer in a patient comprising subcutaneously administering a PD-1 antagonist, e.g., an anti-PD-1 antibody (e.g. … |
MERCK SHARP & DOHME | 2023-10-11 | 2024-05-09 | |
| 121 | A CLOSED-SYSTEM UPSTREAM MANUFACTURING PROCESS FOR DENGUE VIRUS PRODUCTION Related Patents View Abstract: The instant invention discloses a closed-system, serum-free, microcarrier-based up-stream process to produce dengue virus. The process comprises a closed-system cell expansion … |
MERCK SHARP & DOHME | 2022-03-17 | 2024-05-09 | |
| 122 | RECIPROCAL INJECTION DEVICE AND METHODS OF USING SAME Related Patents View Abstract: In some embodiments, a reciprocal injection device includes a platform having a motor, a gearbox operatively coupled to the motor, an actuation slide driven by the motor, a pair … |
MERCK SHARP & DOHME | 2023-10-19 | 2024-05-02 | |
| 123 | ENHANCING IMMUNOGENICITY OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from bacterial capsules are … |
MERCK SHARP & DOHME | 2023-06-22 | 2024-05-02 | |
| 124 | FORMULATIONS OF DENGUE VIRUS VACCINE COMPOSITIONS Related Patents View Abstract: The present invention relates to formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a … |
MERCK SHARP & DOHME | 2023-12-06 | 2024-04-25 | |
| 125 | CHEMOVACCINATION AGAINST PLASMODIUM INFECTION WITH SELECTIVE PLASMEPSIN X INHIBITORS Related Patents View Abstract: The present invention relates to a method of chemovaccination against infection comprising administering to a patient an effective amount of a selective inhibitor of plasmepsin … |
MERCK SHARP & DOHME; WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH | 2022-02-02 | 2024-04-25 | |
| 126 | PHTHALAZINE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 Related Patents View Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, … |
MERCK SHARP & DOHME | 2023-09-21 | 2024-04-18 | |
| 127 | PROTEINS BINDING NKG2D, CD16, AND CEACAM5 Related Patents View Abstract: Multi-specific binding proteins that bind NKG2D, CD16, and CEACAM5 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer … |
MERCK SHARP & DOHME et. al. | 2023-08-08 | 2024-04-18 | |
| 128 | LIPID NANOPARTICLE ADJUVANT COMPOSITION FOR PNEUMOCOCCAL CONJUGATE VACCINES Related Patents View Abstract: The present invention relates generally to the prevention of pneumococcal disease. More specifically, the invention relates to compositions comprising pneumococcal conjugates and … |
MERCK SHARP & DOHME | 2022-02-02 | 2024-04-18 | |
| 129 | STERILE LINE CLIP SEPARATION TOOL Related Patents View Abstract: A system and a method are disclosed for disconnecting clips. A clip separation tool includes two arms, the arms having jaws to receive connected clips at a distal end of the arms … |
MERCK SHARP & DOHME | 2023-12-04 | 2024-04-11 | |
| 130 | EXATECAN-DERIVED TOPOISOMERASE-1 INHIBITORS PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present disclosure is directed to alcohol and amine containing exatecan derivatives, and pharmaceutically acceptable salts or solvates thereof, comprising a structure of … |
MERCK SHARP & DOHME | 2023-08-31 | 2024-04-11 | |
| 131 | METHODS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F Related Patents View Abstract: The present invention provides a method of producing a polysaccharide—protein conjugate with capsular polysaccharide from serotype 19F conjugated to a carrier protein. The method … |
MERCK SHARP & DOHME | 2023-12-15 | 2024-04-04 | |
| 132 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2023-11-09 | 2024-04-04 | |
| 133 | NANOEMULSION ADJUVANT COMPOSITION FOR PNEUMOCOCCAL CONJUGATE VACCINES Related Patents View Abstract: The present invention relates generally to the prevention of pneumococcal disease. More specifically, the invention relates to a composition comprising pneumococcal conjugates and … |
MERCK SHARP & DOHME | 2022-02-02 | 2024-04-04 | |
| 134 | HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA-GAMMAC DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER Related Patents View Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor βγ dimer over binding the IL-2 receptor αβγ trimer … |
MERCK SHARP & DOHME | 2023-10-11 | 2024-03-28 | |
| 135 | REACTION SYNTHESIS PATHFINDER Related Patents View Abstract: A reaction pathfinder system can leverage historical chemical reaction data and determine a synthesis route in a reaction network. The reaction pathfinder system can account for … |
MERCK SHARP & DOHME et. al. | 2022-09-27 | 2024-03-28 | |
| 136 | FACTOR XIA INHIBITORS Related Patents View Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or … |
MERCK SHARP & DOHME | 2022-01-24 | 2024-03-28 | |
| 137 | CLINICAL INVESTIGATION TIMELINESS PREDICTOR Related Patents View Abstract: A clinical investigation management system monitors clinical investigations performed across departments and clinical investigators. The system employs a method for predicting … |
MSD CZECH REPUBLIC et. al. | 2023-09-12 | 2024-03-21 | |
| 138 | METHODS FOR TREATING CANCER OR INFECTION USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY, AN ANTI-LAG3 ANTIBODY, AND AN ANTI-TIGIT ANTIBODY Related Patents View Abstract: Provided herein are methods of treating cancer or infection, which comprise administering to a human patient in need thereof: (a) an anti-human PD-1 monoclonal antibody or antigen … |
MERCK SHARP & DOHME | 2023-09-06 | 2024-03-21 | |
| 139 | Small Molecule Inhibitors of KRAS G12C Mutant Citation: 1 Related Patents View Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W , W , Y, Z, M, L, C , C , R , R , R , R , R , R , R , and the subscripts … |
MERCK SHARP & DOHME | 2023-05-03 | 2024-03-14 | |
| 140 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS Related Patents View Abstract: The present invention is directed to a compound of Formula I: or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising them and methods of … |
MERCK SHARP & DOHME | 2022-02-15 | 2024-03-14 | |
| 141 | AMIDO-SUBSTITUTED PYRIDYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES Related Patents View Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R , R , R , R , R , and R are … |
MERCK SHARP & DOHME | 2021-12-21 | 2024-02-29 | |
| 142 | NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS Related Patents View Abstract: Invented are compounds of formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making … |
MERCK SHARP & DOHME | 2023-09-12 | 2024-02-22 | |
| 143 | FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND CO-FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES Related Patents View Abstract: The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various … |
MERCK SHARP & DOHME | 2023-10-12 | 2024-02-15 | |
| 144 | Small Molecule Inhibitors of KRAS G12C Mutant Citation: 1 Related Patents View Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W , W , Y, Z, M, L, C , C , R , R , R , R , R , R , R , and the subscripts … |
MERCK SHARP & DOHME | 2023-05-03 | 2024-02-08 | |
| 145 | METHODS FOR TREATING CANCER WITH ANTI-PD-1 ANTIBODIES Related Patents View Abstract: The present invention relates to methods for treating cancer in a patient comprising administering a PD-1 antagonist, e.g., an anti-PD-1 antibody or antigen binding fragment … |
MERCK SHARP & DOHME | 2023-09-01 | 2024-01-25 | |
| 146 | RIPK1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as RIPK1 inhibitors and can be useful in preventing, … |
MERCK SHARP & DOHME | 2023-05-17 | 2024-01-25 | |
| 147 | DENSIFIED CO-PRECIPITATED MATERIALS ISOLATED BY THIN FILM EVAPORATION Related Patents View Abstract: The invention encompasses a process for densifying co-precipitated material comprised of an active pharmaceutical ingredient and at least one stabilizing excipient using thin film … |
MERCK SHARP & DOHME | 2023-07-07 | 2024-01-11 | |
| 148 | NOVEL SYNTHETIC PATHWAY TO BELZUTIFAN Related Patents View Abstract: The disclosure provides a novel process and synthetic intermediates for making belzutifan, a HIF-2a inhibitor, useful for the treatment of certain VHL-related indications and … |
MERCK SHARP & DOHME | 2023-07-03 | 2024-01-11 | |
| 149 | COMPOSITIONS AND METHODS FOR TREATING CANCER WITH A COMBINATION OF AN ANTAGONIST OF PD-1 AND AN ANTI-CTLA4 ANTIBODY Related Patents View Abstract: The present invention relates to methods for treating cancer comprising administering an antagonist of PD-1, e.g., anti-PD-1 antibody or antigen binding fragment thereof, and an … |
MERCK SHARP & DOHME | 2022-12-12 | 2024-01-11 | |
| 150 | CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA Related Patents View Abstract: Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X , X , X , A , A , R -R , R , R , R , R , R and R are as herein described. can trap … |
MERCK SHARP & DOHME | 2023-06-13 | 2023-12-21 | |
| 151 | AZIDE INSULIN ANALOGUES Related Patents View Abstract: The present invention relates to insulin analogues and processes of making such insulin analogues by direct conversion of a free amine to an azide via diazo-transfer with an … |
MERCK SHARP & DOHME | 2023-07-31 | 2023-11-16 | |
| 152 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS Related Patents View Abstract: The present disclosure is directed to compounds of Formula I or a pharmaceutically acceptable salt thereof, and their use for the treatment of hRSV and hMPV. … |
MERCK SHARP & DOHME | 2023-05-11 | 2023-11-16 | |
| 153 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMO VIRUS Related Patents View Abstract: The present disclosure is directed to compounds of Formula I: and their use as anti-viral agents for inhibition of the replication of hRSV and hMPV and treatment and prophylaxis … |
MERCK SHARP & DOHME | 2023-05-11 | 2023-11-16 | |
| 154 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2023-03-23 | 2023-10-26 | |
| 155 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS Related Patents View Abstract: The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical … |
MERCK SHARP & DOHME | 2022-11-10 | 2023-10-19 | |
| 156 | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations … |
MERCK SHARP & DOHME | 2023-03-10 | 2023-10-12 | |
| 157 | ADENOSINE A2A AND A2B RECEPTOR DUAL ANTAGONISTS FOR IMMUNO-ONCOLOGY Related Patents View Abstract: The present invention provides compounds of the structural Formula (I) and pharmaceutically acceptable salts thereof, wherein, are as defined herein, pharmaceutical compositions … |
MERCK SHARP & DOHME | 2022-07-21 | 2023-10-12 | |
| 158 | 2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS Related Patents View Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na 1.8 channel activity and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2023-06-05 | 2023-10-05 | |
| 159 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION Related Patents View Abstract: Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit … |
RA PHARMACEUTICALS | 2022-09-27 | 2023-09-28 | |
| 160 | ANTI-COAGULATION FACTOR XI ANTIBODIES Related Patents View Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described. … |
MERCK SHARP & DOHME; ADIMAB | 2023-04-18 | 2023-09-14 | |
| 161 | SYRINGES AND INJECTORS WITH CAPACITIVE SENSING AND METHODS OF MAKING AND USING SAME Related Patents View Abstract: An injecting device includes a reservoir for containing a medicament, a needle in communication with the reservoir and configured to deliver the medicament to a patient’s body, at … |
MERCK SHARP & DOHME | 2023-05-15 | 2023-09-07 | |
| 162 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2023-03-23 | 2023-09-07 | |
| 163 | STABLE FORMULATIONS OF CYTOMEGALOVIRUS Related Patents View Abstract: The present invention relates to stable formulations of a cytomegalovirus (CMV) comprising for example, a genetically modified CMV that is conditionally replication defective, a … |
MERCK SHARP & DOHME | 2022-11-30 | 2023-09-07 | |
| 164 | HPV VACCINE Related Patents View Abstract: The present disclosure provides, among other things, a pharmaceutical composition that includes a lipid nanoparticle adjuvant and an anti-human papillomavirus (HPV) comprising HPV … |
MERCK SHARP & DOHME | 2023-03-10 | 2023-08-31 | |
| 165 | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations … |
MERCK SHARP & DOHME | 2023-03-10 | 2023-08-24 | |
| 166 | ADJUVANTED VACCINES Related Patents View Abstract: Vaccine formulations are described comprising physically separated, lyophilized antigens and adjuvant components, which may be in lyoparticle form, as well as methods of using and … |
MERCK SHARP & DOHME | 2023-02-22 | 2023-07-27 | |
| 167 | ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS Related Patents View Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the … |
MERCK SHARP & DOHME | 2022-12-13 | 2023-07-06 | |
| 168 | PNEUMOCOCCAL CONJUGATE VACCINE FORMULATIONS Related Patents View Abstract: The present invention provides pneumococcal conjugate vaccine formulations comprising surfactant systems incorporating polysorbate 20 or a combination of a poloxamer and a polyol. … |
MERCK SHARP & DOHME | 2023-02-15 | 2023-06-29 | |
| 169 | ADJUVANTED VACCINES Related Patents View Abstract: Vaccine formulations are described comprising physically separated, lyophilized antigens and adjuvant components, which may be in lyoparticle form, as well as methods of using and … |
MERCK SHARP & DOHME | 2023-02-22 | 2023-06-22 | |
| 170 | PCSK9 ANTAGONIST COMPOUNDS Related Patents View Abstract: Disclosed are compounds of Formula A, or a pharmaceutically acceptable salt thereof: where A, X, R , and R are as defined herein, which compounds have properties for antagonizing … |
MERCK SHARP & DOHME | 2022-10-31 | 2023-06-01 | |
| 171 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS Related Patents View Abstract: The present invention relates to monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which … |
MERCK SHARP & DOHME | 2022-11-16 | 2023-05-25 | |
| 172 | SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF Related Patents View Abstract: Described herein are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein A, R , R , R , W, X, Y, Z, m, n and p are as defined herein. The compounds of … |
MERCK SHARP & DOHME | 2022-10-25 | 2023-05-25 | |
| 173 | PCSK9 ANTAGONIST COMPOUNDS Citation: 1 Related Patents View Abstract: Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R , R and R are as defined herein, which compounds have properties for antagonizing PCSK9. Also … |
MERCK SHARP & DOHME | 2022-06-30 | 2023-05-25 | |
| 174 | SCORING METHODS FOR ANTI-PD THERAPY ELIGIBILITY AND COMPOSITIONS FOR PERFORMING SAME Related Patents View Abstract: Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent based on a … |
AGILENT TECHNOLOGIES et. al. | 2023-01-18 | 2023-05-18 | |
| 175 | STABILIZED RSV F PROTEINS AND USES THEREOF Related Patents View Abstract: The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions … |
MERCK SHARP & DOHME | 2022-12-20 | 2023-05-11 | |
| 176 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS Related Patents View Abstract: Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound … |
MERCK SHARP & DOHME | 2022-12-02 | 2023-05-11 | |
| 177 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION Related Patents View Abstract: Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit … |
MERCK SHARP & DOHME et. al. | 2022-08-29 | 2023-04-20 | |
| 178 | NOVEL THERMOSTABLE LIPID NANOPARTICLE AND METHODS OF USE THEREOF Related Patents View Abstract: The present disclosure provides, among other things, a lipid nanoparticle adjuvant composition. The present disclosure provides pharmaceutical compositions that include a stable … |
MERCK SHARP & DOHME | 2022-08-17 | 2023-04-20 | |
| 179 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-09-22 | 2023-04-06 | |
| 180 | ANTIBODY DRUG CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS Related Patents View Abstract: Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and … |
MERCK SHARP & DOHME; AMBRX | 2022-10-26 | 2023-03-30 | |
| 181 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-09-27 | 2023-03-30 | |
| 182 | IN SILICO PROCESS FOR SELECTING PROTEIN FORMULATION EXCIPIENTS Related Patents View Abstract: The invention relates to an in silico screening method to identify candidate excipients for reducing aggregation of a protein in a formulation. The method combines computational … |
MERCK SHARP & DOHME | 2022-11-04 | 2023-03-23 | |
| 183 | METHODS FOR PRODUCING STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDE CARRIER PROTEIN CONJUGATES Related Patents View Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal … |
MERCK SHARP & DOHME | 2022-10-25 | 2023-03-16 | |
| 184 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-09-22 | 2023-03-09 | |
| 185 | FORMULATIONS OF DENGUE VIRUS VACCINE COMPOSITIONS Citation: 1 Related Patents View Abstract: The present invention relates to formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a … |
MERCK SHARP & DOHME | 2022-07-26 | 2023-03-02 | |
| 186 | HAND HELD DEVICE FOR AUTOMATICALLY REMOVING AND REPLACING SCREW-ON CAPS FOR CRYOGENIC TUBES, CRYOGENIC VIALS AND MICROTUBES Related Patents View Abstract: A handheld, battery operated device that, when activated, will grip a screw-cap on the top of a cryogenic vial, microtube, test tube or other pharmaceutical product container, and … |
MERCK SHARP & DOHME | 2022-08-15 | 2023-02-23 | |
| 187 | HPV VACCINE Related Patents View Abstract: The present disclosure provides, among other things, a single-dose vaccine composition that includes a chitosan adjuvant and HPV virus-like particles (VLPs) of at least one type … |
MERCK SHARP & DOHME | 2022-08-04 | 2023-02-16 | |
| 188 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-09-27 | 2023-02-09 | |
| 189 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-09-27 | 2023-01-26 | |
| 190 | NOVEL SYNTHETIC PATHWAY TO BELZUTIFAN AND CRYSTALLINE PHASES OF SYNTHETIC INTERMEDIATES Related Patents View Abstract: The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2α inhibitor, useful for the treatment of cancer. The disclosure also … |
MERCK SHARP & DOHME | 2022-05-20 | 2022-12-08 | |
| 191 | RECOMBINANT EXPRESSION OF CHLAMYDIA MOMP ANTIGEN Related Patents View Abstract: The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of host cells with … |
MERCK SHARP & DOHME | 2022-07-01 | 2022-12-01 | |
| 192 | COMPOUNDS FOR REDUCING THE VISCOSITY OF BIOLOGICAL FORMULATIONS Citation: 1 Related Patents View Abstract: The present invention relates to pegylated amino acid compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein X, R , R , R , R and n are as defined herein. … |
MERCK SHARP & DOHME | 2022-06-29 | 2022-12-01 | |
| 193 | CYCLOALKYL 3-OXOPIPERAZINE CARBOXAMIDES AND CYCLOHETEROALKYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS Related Patents View Abstract: Novel compounds of structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na 1.8 channel activity and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2022-05-05 | 2022-12-01 | |
| 194 | P116 ANTIBODIES Related Patents View Abstract: The present invention provides antibodies and antigen-binding fragments thereof that bind PI16 and block binding of ILT3 to PI16. … |
MERCK SHARP & DOHME | 2022-05-16 | 2022-11-17 | |
| 195 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-06-24 | 2022-10-13 | |
| 196 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-06-24 | 2022-10-13 | |
| 197 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-06-24 | 2022-10-13 | |
| 198 | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE-CARRIER PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides capsular polysaccharides from serotypes identified using NMR. The present invention further provides polysaccharide-protein conjugates in which … |
MERCK SHARP & DOHME | 2022-06-24 | 2022-10-13 | |
| 199 | PROCESSES FOR THE FORMULATION OF PNEUMOCOCCAL POLYSACCHARIDES FOR CONJUGATION TO A CARRIER PROTEIN Related Patents View Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from to a carrier protein. These process are serotype … |
MERCK SHARP & DOHME | 2022-06-09 | 2022-09-22 | |
| 200 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS Related Patents View Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na 1.8 channel activity and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2022-05-24 | 2022-09-15 |