Clinical Digest: A Comprehensive Review of Recent Pfizer Patents
This compilation provides an overview of Pfizer‘s latest patent inventions. Alongside these patents are potentially related patents, which may include work from Pfizer or other entities exploring similar therapeutic areas. This resource aims to offer researchers, clinicians, investors, and the broader public insights into Pfizer’s current research and development pipeline. By presenting patent details alongside related intellectual property (regardless of origin), this compilation facilitates a broader understanding of Pfizer’s strategic focus and how it potentially compares to direct and indirect competitors in these therapeutic spaces. This information can be valuable for identifying emerging trends in drug development, assessing the commercial potential of specific research programs, and understanding the broader landscape of scientific contributions related to Pfizer’s patent inventions. (Last updated on: 2025-05-22)
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TABLE 1: Clinical Digest: A Comprehensive Review of Recent Pfizer Patents
| Title | Applicant/Assignee | Filing Date | Publish Date | Grant Date | |
|---|---|---|---|---|---|
| 1 | NOVEL ANTIBODIES AND ANTIBODY CONJUGATES FOR THE TREATMENT OF METABOLIC DISORDERS Related Patents View Abstract: Disclosed herein are novel antibodies, novel agonist peptides, and novel dual agonist peptides. Further disclosed herein are novel antibody conjugates comprising the novel … |
PFIZER | 2024-11-14 | 2025-05-22 | |
| 2 | LFA3 VARIANTS AND COMPOSITIONS AND USES THEREOF Related Patents View Abstract: The invention provides LFA3 polypeptide molecules, e.g., variant LFA3 fusion polypeptide molecules. The invention includes uses, and associated methods of using the LFA3 … |
PFIZER; REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2024-09-06 | 2025-05-22 | |
| 3 | Methods for Incorporating Azido Groups in Bacterial Capsular Polysaccharides Related Patents View Abstract: The present invention relates to fermentation methods for incorporating azido groups in bacterial capsular polysaccharides. The invention also relates to capsular polysaccharides … |
PFIZER | 2023-02-22 | 2025-05-22 | |
| 4 | ANTIBODIES AND ANTIBODY-DRUG CONJUGATES SPECIFIC FOR CD123 AND USES THEREOF Related Patents View Abstract: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising … |
PFIZER | 2024-12-03 | 2025-05-15 | |
| 5 | ANTI-MIGIS-alpha ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: Provided herein are antibodies (including antigen-binding fragments thereof) that specifically bind to MIGIS-α, including for example without limitation, bispecific MIGIS-α/CD3 … |
PFIZER et. al. | 2024-11-08 | 2025-05-15 | |
| 6 | TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF Related Patents View Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful … |
PFIZER | 2024-11-05 | 2025-05-08 | |
| 7 | CHIMERIC ANTIGEN RECEPTORS TARGETING CD70 Related Patents View Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and … |
PFIZER | 2024-10-17 | 2025-05-08 | |
| 8 | Pyrrolo[2,3-d]pyrimidinyl, Pyrrolo[2,3-b]pyrazinyl and Pyrrolo[2,3-d]pyridinyl Acryla-mides Related Patents View Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for … |
PFIZER | 2024-07-15 | 2025-05-01 | |
| 9 | AMPHIPHILIC TLR7/8 ADJUVANTS AND USES THEREOF Related Patents View Abstract: The invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, L, X, Y and p are as defined in the description; to their use in … |
PFIZER | 2024-07-03 | 2025-05-01 | |
| 10 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF Related Patents View Abstract: Described herein are compounds of Formula I: I and their pharmaceutically acceptable salts, wherein R , R , R , R , R , R , t1, Y , and Y are defined herein; their use as MC4R … |
PFIZER | 2022-12-05 | 2025-04-24 | |
| 11 | METHODS AND DOSING REGIMENS COMPRISING A CDK2 INHIBITOR FOR THE TREATMENT OF CANCER Related Patents View Abstract: The disclosure provides methods of treating cancer in a subject in need thereof comprising administering to the subject a therapeutically effective amount of PF-07104091, as a … |
PFIZER | 2022-12-01 | 2025-04-24 | |
| 12 | Solid Forms of 2-[(4-{6-[(4-Cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid, 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-amine Salt Related Patents View Abstract: The invention provides solid forms of 2-[(4-{6-[(4-Cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid, … |
PFIZER | 2022-08-25 | 2025-04-24 | |
| 13 | Nitrogen-Linked Benzisoxazole Sulfonamide Derivatives Related Patents View Abstract: The present invention relates to compounds of Formula (I): … |
PFIZER et. al. | 2024-10-01 | 2025-04-17 | |
| 14 | ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF Related Patents View Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from lipopolysaccharides and conjugates thereof. … |
PFIZER | 2024-09-09 | 2025-04-17 | |
| 15 | MULTIPLEXED BIOLOGICAL ASSAY DEVICE WITH ELECTRONIC READOUT Related Patents View Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed … |
PFIZER | 2024-12-19 | 2025-04-10 | |
| 16 | ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF Related Patents View Abstract: This invention relates to compositions that include a polypeptide derived from or a fragment thereof; and modified O-polysaccharide molecules derived from lipopolysaccharides … |
PFIZER | 2024-09-09 | 2025-04-10 | |
| 17 | KLF2 INDUCING DEUTERATED COMPOUNDS AND USES THEREOF Related Patents View Abstract: The present disclosure provides deuterated compounds that are inducers of KLF2 and pharmaceutical compositions comprising the same. The present disclosure further provides method … |
RIPARIAN PHARMACEUTICALS; PFIZER | 2024-08-02 | 2025-04-03 | |
| 18 | Nitrile-Containing Antiviral Compounds Related Patents View Abstract: The invention relates to compounds of Formula I″ wherein R, R , R , R , p, q and q′ are as defined herein, pharmaceutical compositions comprising the compounds, methods of … |
PFIZER | 2024-10-16 | 2025-03-27 | |
| 19 | Crystalline form of (2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one Related Patents View Abstract: Described herein is a crystalline form of … |
PFIZER | 2024-11-21 | 2025-03-13 | |
| 20 | Dosing Regime For Treatment of Chronic Hand Eczema Related Patents View Abstract: Method for treating moderate to severe chronic hand eczema in a subject in need thereof, which method comprises the step of administering to said subject a therapeutically … |
PFIZER | 2022-01-31 | 2025-03-13 | |
| 21 | AQUEOUS FORMULATION COMPRISING 1-(4-{[4-(DIMETHYLAMINO)PIPERIDIN-1-YL]CARBONYL}PHENYL)-3-[4-(4,6-DIMORPHOLIN-4-YL-1,3,5-TRIAZIN-2-YL)PHENYL]UREA Related Patents View Abstract: The present invention relates to a pharmaceutical aqueous formulation comprising … |
PFIZER | 2024-09-05 | 2025-02-27 | |
| 22 | Amorphous Form of (S)-2-(5-((3-Ethoxypyridin-2-YL)Oxy)Pyridin-3-YL)-N-(Tetrahydrofuran-3-YL)Pyrimidine-5-Carboxamide Related Patents View Abstract: Solid forms of (S)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-(tetrahydrofuran-3-yl)pyrimidine-5-carboxamide, including crystalline forms and an amorphous form, in addition … |
PFIZER | 2022-08-23 | 2025-02-27 | |
| 23 | Deuterated Antiviral Compounds Related Patents View Abstract: The invention relates to compounds of Formula (I) wherein Y , Y , Y , Y , Y , Y , Y , Y , Y , Y and Y are as defined herein and to their use in medicine; to compositions … |
PFIZER | 2024-08-09 | 2025-02-13 | |
| 24 | COMBINATION THERAPIES AND USES FOR TREATING CANCER Related Patents View Abstract: The present disclosure relates to the treatment of cancer and/or cancer-associated disease. Certain aspects relate to the treatment of an individual having cancer or … |
PFIZER | 2022-12-12 | 2025-02-13 | |
| 25 | BLISTER PACKAGING FOR PHARMACEUTICALS Related Patents View Abstract: A blister package is disclosed herein. The blister package includes a body, a plurality of pockets, and a top seal. The body has a top surface and a bottom surface opposite the … |
PFIZER | 2022-12-16 | 2025-02-06 | |
| 26 | METHODS AND DOSING REGIMENS COMPRISING A CDK2 INHIBITOR AND A CDK4 INHIBITOR FOR TREATING CANCER Related Patents View Abstract: This disclosure relates to combination therapies for use in treating cancer, comprising a CDK2 inhibitor of Formula (I) and a selective CDK4 inhibitor of Formula (II), each as … |
PFIZER | 2022-12-01 | 2025-02-06 | |
| 27 | CDK4 INHIBITOR FOR THE TREATMENT OF CANCER Related Patents View Abstract: The disclosure provides a method of treating cancer comprising administering to a subject in need thereof with a therapeutically effective amount of PF-07220060. The disclosure … |
PFIZER; PFIZER | 2022-11-29 | 2025-02-06 | |
| 28 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS Related Patents View Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for … |
PFIZER | 2024-10-01 | 2025-01-30 | |
| 29 | ANTIBODIES SPECIFIC FOR CD70 AND THEIR USES Related Patents View Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 … |
PFIZER | 2024-04-18 | 2025-01-09 | |
| 30 | IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATED CAPSULAR SACCHARIDE ANTIGENS, KITS COMPRISING THE SAME AND USES THEREOF Related Patents View Abstract: The present invention relates to new immunogenic compositions comprising conjugated capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions … |
PFIZER | 2024-03-19 | 2025-01-09 | |
| 31 | HEALTH INFORMATION PLATFORM Related Patents View Abstract: A system and methods of providing credibility and trustworthiness to users in a wellness platform. A method for providing search results to a user in an app including searching a … |
PFIZER | 2024-06-26 | 2025-01-02 | |
| 32 | POLYNUCLEOTIDE COMPOSITIONS AND USES THEREOF Related Patents View Abstract: The invention relates to RNA molecules encoding an fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a … |
PFIZER | 2024-06-11 | 2025-01-02 | |
| 33 | COMPOSITIONS AND METHODS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN Related Patents View Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant toxin A and/or a mutant toxin B. The mutant toxin may include a glucosyltransferase … |
PFIZER | 2024-03-01 | 2025-01-02 | |
| 34 | CALICHEAMICIN DERIVATIVES AND ANTIBODY DRUG CONJUGATES THEREOF Related Patents View Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC’s), and to payload-linker compounds and ADC compounds … |
PFIZER | 2024-04-05 | 2024-12-12 | |
| 35 | CRYSTALLINE FORM OF AZALACTAM COMPOUND Related Patents View Abstract: This disclosure relates to a crystalline form of 4-[( R)- -aminopropyl]- -{ -[( S)- -methyl- -dihydro- H-pyrro-lo[ -c][ ]triazol- -yl]pyridin- -yl}- -[( R)- -methylpyrrolidin- … |
PFIZER | 2022-10-04 | 2024-12-12 | |
| 36 | SYSTEMS AND METHODS FOR PERFORMING BIOLOGICAL ASSAYS Related Patents View Abstract: Systems and methods for performing biological assays are provided herein. The systems and methods determine one or more characteristics of a nucleic acid amplification sample … |
PFIZER | 2024-08-15 | 2024-12-05 | |
| 37 | WEARABLE COMPANION FOR DETECTING THE CYTOKINE RELEASE SYNDROME Related Patents View Abstract: Embodiments disclosed herein may provide digital medicine support for predicting and mitigating side effects of bispecific antibody treatment (e.g., Pfizer’s Elranatamab) for … |
PFIZER | 2022-12-22 | 2024-12-05 | |
| 38 | METABOLITES OF GLP1R AGONISTS Related Patents View Abstract: The present invention provides compounds of Formula XA-1, XA-2, XA-3, XA-4, XA-5, or XA-6, or metabolites of Compound 1 or metabolites of a compound of Formula I, PA-I, or PA-III, … |
PFIZER | 2024-07-31 | 2024-11-28 | |
| 39 | Modulators of STING (Stimulator of Interferon Genes) Related Patents View Abstract: Provided herein are compounds of the general formula (I): and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing … |
PFIZER | 2024-03-18 | 2024-11-21 | |
| 40 | DIGITAL MEDICINE COMPANION FOR TREATING AND MANAGING SKIN DISEASES Related Patents View Abstract: A digital medicine companion for managing skin diseases (e.g., atopic dermatitis, psoriasis) may include patient wearable devices passively collecting patient data, patient user … |
PFIZER | 2022-12-16 | 2024-11-21 | |
| 41 | Immunogenic Compositions Comprising Conjugated Capsular Saccharide Antigens and Uses Thereof Related Patents View Abstract: The present invention relates to new immunogenic compositions comprising conjugated capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of … |
PFIZER | 2023-12-06 | 2024-11-14 | |
| 42 | CD21 ANTIBODIES AND USES THEREOF Related Patents View Abstract: Provided herein are anti-CD21 antibodies or antigen binding fragments thereof and their use in the treatment of autoimmune diseases or disorders. … |
CHILDREN’S MEDICAL CENTER; PFIZER | 2022-07-06 | 2024-11-14 | |
| 43 | GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR ANTAGONISTS AND USES THEREOF Related Patents View Abstract: Described herein are compounds of Formula I: and their pharmaceutically acceptable salts, wherein R , R , R , L , T , T , T , T , t1, and t2 are defined herein; their use as GIPR … |
PFIZER | 2024-04-12 | 2024-11-07 | |
| 44 | N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS Related Patents View Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate … |
PFIZER | 2023-05-03 | 2024-11-07 | |
| 45 | LILRB1 and LILRB2 ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is directed to Anti-LILRB1 and anti-LILRB2 bispecific antibodies, anti-LILRB1 antibodies, and anti-LILRB2 antibodies, their uses and pharmaceutical compositions … |
PFIZER | 2024-04-18 | 2024-10-31 | |
| 46 | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof Related Patents View Abstract: The present invention relates to new immunogenic compositions comprising conjugated capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions … |
PFIZER | 2024-04-12 | 2024-10-24 | |
| 47 | SUBSTITUTED INDAZOLE PROPIONIC ACID DERIVATIVE COMPOUNDS AND USES THEREOF Related Patents View Abstract: The invention relates to substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers … |
PFIZER | 2024-04-04 | 2024-10-10 | |
| 48 | Pyrido[4,3-d]pyrimidine Compounds Related Patents View Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for … |
PFIZER | 2024-04-03 | 2024-10-10 | |
| 49 | COMBINATION THERAPY COMPRISING A PKC INHIBITOR AND A C-MET INHIBITOR Related Patents View Abstract: Provided herein is a combination therapy and methods of using such combination therapy to treat diseases or disorders associated with PKC and c-MET. … |
IDEAYA BIOSCIENCES et. al. | 2022-12-05 | 2024-10-10 | |
| 50 | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof Related Patents View Abstract: The present invention relates to new immunogenic compositions comprising conjugated capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions … |
PFIZER | 2024-03-29 | 2024-10-03 | |
| 51 | ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF Related Patents View Abstract: This invention provides a polypeptide derived from or a fragment thereof, including compositions and methods thereof. In one embodiment, the compositions comprise a polypeptide … |
PFIZER | 2024-03-06 | 2024-10-03 | |
| 52 | Improved Expression Vectors and Uses Thereof Related Patents View Abstract: Vectors and nucleic acid constructs for improved antibody production are provided. Also provided are methods of making and using the vectors and constructs. … |
PFIZER | 2022-07-29 | 2024-10-03 | |
| 53 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS Related Patents View Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the … |
PFIZER | 2024-03-18 | 2024-09-26 | |
| 54 | METHODS FOR PRODUCING OF LIPIDS Related Patents View Abstract: Methods for producing a compound of Formula I, Formula I, wherein R and R are independently a i) linear or branched or cyclic, ii) saturated or unsaturated, and iii) substituted … |
PFIZER | 2022-01-12 | 2024-09-26 | |
| 55 | PHARMACEUTICAL COMPOSITIONS CONTAINING ADENO-ASSOCIATED VIRAL VECTOR Related Patents View Abstract: The present invention provides compositions comprising a recombinant AAV (rAAV) vector and one or more pharmaceutically acceptable excipients. The compositions have improved … |
PFIZER | 2022-03-29 | 2024-09-19 | |
| 56 | IMMUNOGENIC COMPOSITIONS AND USES THEREOF Related Patents View Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from , commonly referred to as group B (GBS), conjugated to a carrier protein, and … |
PFIZER | 2024-05-10 | 2024-09-12 | |
| 57 | SOLID FORMS OF PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS Related Patents View Abstract: The present disclosure provides solid forms of … |
PFIZER | 2024-05-06 | 2024-09-12 | |
| 58 | SELECTIVELY VENTED BIOLOGICAL ASSAY DEVICES AND ASSOCIATED METHODS Related Patents View Abstract: Selectively vented biological assay devices and methods of performing biological assays with such devices are provided herein. Disclosed devices include a selective venting … |
PFIZER | 2024-05-01 | 2024-09-12 | |
| 59 | NOVEL DRUGGABLE REGIONS IN THE HUMAN CYTOMEGALOVIRUS GLYCOPROTEIN B POLYPEPTIDE AND METHODS OF USE THEREOF Related Patents View Abstract: The present invention relates to a method for identifying a candidate therapeutic for a disease caused by infection with a human cytomegalovirus (HCMV) having a glycoprotein B … |
PFIZER | 2022-02-21 | 2024-09-12 | |
| 60 | CDK2 INHIBITORS Related Patents View Abstract: This invention relates to compounds of Formula (I) … |
PFIZER | 2023-07-05 | 2024-09-05 | |
| 61 | CETYLTRIMETHYLAMMONIUM BROMIDE (CTAB) AS A LYSIS AND FLOCCULATION REAGENT IN GENE THERAPY DOWNSTREAM PROCESSES Related Patents View Abstract: The present disclosure describes improved methods for use in purifying biological products made by host cells. In some embodiments, the improved methods comprise one or more steps … |
PFIZER | 2024-02-26 | 2024-08-29 | |
| 62 | ANTI-CXCR5 ANTIBODIES AND COMPOSITIONS AND USES THEREOF Related Patents View Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to CXCR5. The antibodies can be afucosylated and exhibit increased ADCC compared … |
PFIZER; REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2024-03-04 | 2024-08-22 | |
| 63 | Devices and Methods for Modifying Optical Properties Related Patents View Abstract: Devices and methods for modifying optical properties of biological samples or aspects thereof are provided. The subject methods include generating a reaction product with a device … |
PFIZER | 2024-04-15 | 2024-08-15 | |
| 64 | PRODUCTION OF ADENO-ASSOCIATED VIRUS VECTOR IN INSECT CELLS Related Patents View Abstract: The present disclosure relates to compositions and methods for the optimal large-scale production of rAAV vectors using the baculovirus expression vector system in insect cells. … |
PFIZER | 2022-06-20 | 2024-08-15 | |
| 65 | ANTI-EDB ANTIBODIES AND ANTIBODY-DRUG CONJUGATES Related Patents View Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same. … |
PFIZER | 2023-12-04 | 2024-08-08 | |
| 66 | RECOMBINANT EXPRESSION OF KLEBSIELLA PNEUMONIAE O-ANTIGENS IN ESCHERICHIA COLI Related Patents View Abstract: This invention provides a recombinant ( ) host cell for producing a ( ) O-antigen, wherein the host cell comprises a polynucleotide encoding the O-antigen, including methods … |
PFIZER | 2022-05-23 | 2024-08-08 | |
| 67 | VACCINES AGAINST RESPIRATORY DISEASES Related Patents View Abstract: The present disclosure relates to hMPV F, PIV3 F and PIV1 F protein mutants, nucleic acids or vectors encoding a hMPV F, PIV3 F and PIV1 F protein mutant, compositions comprising … |
PFIZER | 2024-01-16 | 2024-08-01 | |
| 68 | IMMUNOGENIC COMPOSITIONS AND USES THEREOF Related Patents View Abstract: The present disclosure relates to compositions comprising RNA molecules encoding an antigen derived from influenza, wherein the RNA may be formulated in a lipid nanoparticle … |
PFIZER | 2023-12-07 | 2024-08-01 | |
| 69 | BTLA Fusion Protein Agonists and Uses Thereof Related Patents View Abstract: The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins … |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; PFIZER | 2024-02-15 | 2024-07-25 | |
| 70 | Papain-like protease (PLpro) inhibitors Related Patents View Abstract: The invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof as defined in the description; to their use in medicine; to compositions containing … |
PFIZER | 2023-12-07 | 2024-07-25 | |
| 71 | IMMUNOGENIC COMPOSITIONS FOR USE IN PNEUMOCOCCAL VACCINES Related Patents View Abstract: An object of the present invention is to provide immunogenic compositions for protection against , in particular against serogroup 10A and 39, while limiting the number of … |
PFIZER | 2024-02-01 | 2024-07-18 | |
| 72 | HSD17B13 Inhibitors and/or Degraders Related Patents View Abstract: Described herein are 3-fluoro-4-hydroxybenzamide-containing inhibitors and/or degraders, and pharmaceutical compositions containing 3-fluoro-hydroxybenzamide-containing inhibitors … |
PFIZER | 2023-12-15 | 2024-07-18 | |
| 73 | CLAUDIN 18.2 TARGETING CHIMERIC ANTIGEN RECEPTORS AND BINDING AGENTS AND USES THEREOF Related Patents View Abstract: Provided herein are Claudin 18.2 binding agents and chimeric antigen receptors (CARs) comprising a Claudin 18.2 binding molecule that specifically binds to Claudin 18.2; and … |
ALLOGENE THERAPEUTICS et. al. | 2023-11-28 | 2024-07-04 | |
| 74 | COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIUM DIFFICILE Related Patents View Abstract: In one aspect, the invention relates to an immunogenic composition that includes a toxoid A and/or a toxoid B, and methods of use thereof. In another aspect, the invention … |
PFIZER | 2023-08-09 | 2024-07-04 | |
| 75 | COMBINATION THERAPY COMPRISING A PKC INHIBITOR AND A MEK INHIBITOR Related Patents View Abstract: Provided herein is a combination therapy and methods of using such combination therapy to treat diseases or disorders associated with PKC and MEK. … |
IDEAYA BIOSCIENCES et. al. | 2022-04-14 | 2024-06-27 | |
| 76 | METHODS FOR PRODUCING OF LIPIDS Related Patents View Abstract: The present disclosure provides methods for producing a compound having a chemical formula of Formula I, wherein R and R are independently a i) linear or branched or cyclic, ii) … |
PFIZER | 2022-04-06 | 2024-06-27 | |
| 77 | Azalactam Compounds as HPK1 Inhibitors Related Patents View Abstract: This invention relates to compounds of general Formula I … |
PFIZER | 2023-05-08 | 2024-06-20 | |
| 78 | IMMUNOGENIC COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE AGAINST CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE Related Patents View Abstract: The present invention relates to immunogenic compositions that comprise a toxoid A and/or a toxoid B, and an adjuvant, and methods of use thereof. The present invention further … |
PFIZER | 2023-12-11 | 2024-06-13 | |
| 79 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES Related Patents View Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R , R , L, … |
PFIZER | 2023-12-07 | 2024-06-13 | |
| 80 | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof Related Patents View Abstract: The present invention relates to new immunogenic compositions comprising conjugated capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of … |
PFIZER | 2023-11-20 | 2024-06-06 | |
| 81 | ANTI-EDB ANTIBODIES AND ANTIBODY-DRUG CONJUGATES Related Patents View Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same. … |
PFIZER | 2023-10-23 | 2024-06-06 | |
| 82 | COMPOUNDS FOR THE ACTIVATION OF AMPK Related Patents View Abstract: Described herein are compounds of Formula I, … |
PFIZER | 2023-10-11 | 2024-06-06 | |
| 83 | Combination of Talazoparib and an Anti-Androgen for the Treatment of DDR Gene Mutated Metastatic Castration-Sensitive Prostate Cancer Related Patents View Abstract: This invention relates to combination therapies comprising talazoparib, or a pharmaceutically acceptable salt thereof, and an anti-androgen, or a pharmaceutically acceptable salt … |
PFIZER; ASTELLAS PHARMA | 2022-03-21 | 2024-06-06 | |
| 84 | INTERFERON BETA ANTIBODIES AND USES THEREOF Related Patents View Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments … |
PFIZER et. al. | 2023-11-16 | 2024-05-30 | |
| 85 | Treatment of Breast Cancer with Amcenestrant and Palbociclib Related Patents View Abstract: The present disclosure provides methods of treating breast cancer with a combination of amcenestrant and palbociclib. … |
SANOFI; PFIZER | 2022-03-02 | 2024-05-30 | |
| 86 | BENZODIAZEPINES FOR TREATING OR PREVENTING RESPIRATORY SYNCYTIAL VIRUS INFECTION Related Patents View Abstract: Pharmacuetical Compounds Benzodiazepine derivatives of formula (I): wherein: R is H or F; R is selected from formula (II) and formula (III) R is C -C alkyl which is unsubstituted … |
PFIZER | 2022-02-24 | 2024-05-30 | |
| 87 | METHODS OF ADMINISTERING LONG-ACTING GROWTH HORMONE POLYPEPTIDES Related Patents View Abstract: The subject matter described herein is directed to methods of treating growth hormone related disorders by administering a long-acting recombinant human growth hormone. In another … |
PFIZER; OPKO BIOLOGICS | 2022-03-17 | 2024-05-23 | |
| 88 | ORAL SOLUTION FORMULATION Related Patents View Abstract: The present invention relates to an oral solution formulation or an oral powder for constitution comprising … |
PFIZER | 2024-01-23 | 2024-05-16 | |
| 89 | Antibody Purification Related Patents View Abstract: Antibody compositions and methods for the purification of antibodies are provided. Purification methods provided involve the use of hydroxyapatite resin (HA) to separate an … |
PFIZER | 2023-12-21 | 2024-05-16 | |
| 90 | ANTI-EDB ANTIBODIES AND ANTIBODY-DRUG CONJUGATES Related Patents View Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same. … |
PFIZER | 2023-10-23 | 2024-05-16 | |
| 91 | Methods For Treatment of Vitiligo Related Patents View Abstract: Method for treating vitiligo, including active and stable non-segmental vitiligo, using compounds and analogues which inhibit certain kinases including Janus Kinase (JAK), said … |
PFIZER | 2022-03-28 | 2024-05-16 | |
| 92 | SOLID STATE FORMS OF (S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE AND USES THEREOF Related Patents View Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of … |
PFIZER | 2024-01-16 | 2024-05-09 | |
| 93 | HSD17B13 INHIBITORS AND/OR DEGRADERS Related Patents View Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing … |
PFIZER | 2023-10-06 | 2024-05-09 | |
| 94 | PURIFICATION OF ANTIBODY DRUG CONJUGATES USING A SODIUM PHOSPHATE GRADIENT Related Patents View Abstract: Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate … |
PFIZER | 2023-05-23 | 2024-05-09 | |
| 95 | Diacylglycerol Acyl Transferase 2 Inhibitors Related Patents View Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are … |
PFIZER | 2023-11-28 | 2024-05-02 | |
| 96 | COMPOUND FOR THE TREATMENT OF CANCER Related Patents View Abstract: The invention relates to 4-((6-(2,2-Difluoroethyl)-8-(2-hydroxy-2-methylcyclopentyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)piperidine-1-sulfonamide or … |
PFIZER | 2023-10-17 | 2024-05-02 | |
| 97 | GLP-1 Receptor Agonists and Uses Thereof Related Patents View Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising … |
PFIZER | 2023-11-20 | 2024-04-25 | |
| 98 | Colorimetric Detection of Nucleic Acid Amplification Related Patents View Abstract: Colorimetry is used to detect amplification reaction products. A sample is contacted with a reaction mix under conditions such that an amplification reaction occurs and produces … |
PFIZER | 2023-02-20 | 2024-04-25 | |
| 99 | Benzimidazole Derivatives and Their Use As Inhibitors of ITK For The Treatment of Skin Disease Related Patents View Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R to R are as defined in the description; to their use in medicine; … |
PFIZER | 2021-12-13 | 2024-04-25 | |
| 100 | Novel SIK Inhibitors Related Patents View Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A and A are independently O or S; X is selected from CH , CD , NR , O, and S, … |
PFIZER | 2023-09-13 | 2024-04-18 | |
| 101 | Antibodies Specific for CD47, PD-L1, and Uses Thereof Related Patents View Abstract: Antibodies that specifically bind to CD47 and antibodies that specifically bind to PD-L1 are provided, as well as CD47/PD-L1 bispecific antibodies. Also provided are uses of these … |
PFIZER | 2023-05-18 | 2024-04-18 | |
| 102 | Methods of Protecting RNA Related Patents View Abstract: The present disclosure provides methods of protecting ribonucleic acid (RNA) from degradation under certain conditions by contacting the RNA with an amino acid. The present … |
PFIZER | 2022-02-15 | 2024-04-18 | |
| 103 | Pyrido[2,3-D]Imidazole Derivatives and Their Use As Inhibitors of ITK for the Treatment of Skin Disease Related Patents View Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R to R are as defined in the description; to their use in medicine; … |
PFIZER | 2021-12-13 | 2024-04-18 | |
| 104 | MULTISPECIFIC ANTIBODIES AND USES THEREOF Related Patents View Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that … |
PFIZER | 2023-02-28 | 2024-04-11 | |
| 105 | NOVEL ACC INHIBITORS Related Patents View Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, … |
PFIZER | 2023-07-26 | 2024-04-04 | |
| 106 | SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH Related Patents View Abstract: The present invention relates to a compound of the formula I wherein R to R , A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the … |
PFIZER | 2023-03-15 | 2024-04-04 | |
| 107 | HUMAN CYTOMEGALOVIRUS GB POLYPEPTIDE Related Patents View Abstract: The present invention relates to polypeptides and cytomegalovirus (CMV) antigens that include at least two introduced amino acid mutations relative to the amino acid sequence of … |
PFIZER | 2023-11-10 | 2024-03-28 | |
| 108 | B-CELL MATURATION ANTIGEN (BCMA) ANTI-IDIOTYPIC ANTIBODIES Related Patents View Abstract: Provided herein are anti-idiotype antibodies that specifically recognize anti-BCMA antibody moieties, in particular, anti-BCMA antibody moieties present in recombinant receptors, … |
ALLOGENE THERAPEUTICS et. al. | 2023-09-18 | 2024-03-28 | |
| 109 | CELLS AND METHOD OF CELL CULTURE Related Patents View Abstract: The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention … |
PFIZER | 2023-07-12 | 2024-03-21 | |
| 110 | ANTI-BMP9 ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to bone morphogenetic protein-9 (BMP9) are provided. Embodiments include uses, and associated methods of … |
PFIZER; BRIGHAM AND WOMEN’S HOSPITAL; GENERAL HOSPITAL | 2023-05-31 | 2024-03-14 | |
| 111 | CD1a ANTIBODIES AND USES THEREOF Related Patents View Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to Cluster of Differentiation 1a (CD1a) are provided. Embodiments include uses, and associated methods of … |
PFIZER; CHILDREN’S MEDICAL CENTER | 2023-07-19 | 2024-03-07 | |
| 112 | ANTI-E-SELECTIN ANTIBODIES, COMPOSITIONS AND METHODS OF USE Related Patents View Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to E-selectin. The invention includes uses, and associated methods of using the … |
PFIZER | 2023-02-27 | 2024-03-07 | |
| 113 | Solid Forms of an eIF4E Inhibitor Related Patents View Abstract: The present invention relates to solid forms of … |
PFIZER et. al. | 2021-12-22 | 2024-03-07 | |
| 114 | SOLID FORMS OF A CDK2 INHIBITOR Related Patents View Abstract: The invention relates to solid forms of (1R,3S)-3-[3-({[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl}amino)-1H-pyrazol-5-yl]cyclopentyl propan-2-ylcarbamate, to … |
PFIZER | 2021-12-21 | 2024-03-07 | |
| 115 | IMPROVED PHARMACEUTICAL COMPOSITIONS CONTAINING ADENO-ASSOCIATED VIRAL VECTOR Related Patents View Abstract: The present invention provides compositions comprising a recombinant AAV and one or more pharmaceutically acceptable excipients. The compositions have improved stability and shelf … |
SANGAMO THERAPEUTICS; PFIZER | 2021-12-17 | 2024-02-29 | |
| 116 | GLP-1 Receptor Agonists and Uses Thereof Related Patents View Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising … |
PFIZER | 2023-10-09 | 2024-02-22 | |
| 117 | ANTI-TL1A ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The present invention discloses an isolated antibody that specifically binds to TL1A, comprising a heavy chain variable region (TL1A-VH) and a light chain variable region … |
PFIZER; BRISTOL-MYERS SQUIBB | 2023-05-09 | 2024-02-22 | |
| 118 | ANTI- IL27R ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The present invention relates to antibodies that specifically bind to one or both of IL27RA and gp130. The present invention further relates to bispecific antibodies that … |
PFIZER | 2023-08-01 | 2024-02-15 | |
| 119 | SOLID STATE FORMS OF (S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE AND USES THEREOF Related Patents View Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of … |
PFIZER | 2023-07-28 | 2024-02-15 | |
| 120 | HILIC UPLC-MS Method For Separating and Analyzing Intact Adeno-Associated Virus Capsid Proteins Related Patents View Abstract: Chromatographic method for separation of AAV capsid proteins using hydrophilic-interaction chromatography (HILIC). The method provides the ability to quantify capsid protein ratio … |
PFIZER | 2021-12-13 | 2024-02-15 | |
| 121 | METHODS FOR PURIFICATION OF AAV VECTORS BY AFFINITY CHROMATOGRAPHY Related Patents View Abstract: The present disclosure provides methods for purifying a recombinant AAV (rAAV) vector from a solution by affinity chromatography to produce an eluate enriched for AAV vectors … |
PFIZER | 2021-12-20 | 2024-02-08 | |
| 122 | GLP-1 RECEPTOR AGONISTS AND USES THEREOF Related Patents View Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods … |
PFIZER | 2023-09-28 | 2024-02-01 | |
| 123 | IMMUNOGENIC GLYCOPROTEIN CONJUGATES Related Patents View Abstract: The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In … |
PFIZER | 2023-06-06 | 2024-02-01 | |
| 124 | CD47 BLOCKADE THERAPY WITH CD38 ANTIBODY Related Patents View Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blocking agent and a CD38 antibody such as daratumumab. The anti-cancer effect of SIRPαFc is … |
PFIZER | 2023-08-30 | 2024-01-18 | |
| 125 | THERAPEUTIC ANTIBODIES AND THEIR USES Related Patents View Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or … |
PFIZER | 2023-08-25 | 2024-01-18 | |
| 126 | THERAPEUTIC ANTIBODIES AND THEIR USES Related Patents View Abstract: The present invention relates to antibodies that specifically bind to B7-H4 (B7 Homology 4, encoded by gene VTCN1) and bispecific antibodies that specifically bind to both B7-H4 … |
PFIZER | 2023-08-15 | 2024-01-18 | |
| 127 | IMAGE-BASED DISEASE DIAGNOSTICS USING A MOBILE DEVICE Related Patents View Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient … |
PFIZER | 2023-08-02 | 2024-01-18 | |
| 128 | SELF-AMPLIFYING RNA ENCODING AN INFLUENZA VIRUS ANTIGEN Related Patents View Abstract: Self-amplifying RNA (saRNA) molecules encoding an influenza virus antigen and methods of use thereof are disclosed herein. … |
PFIZER | 2023-07-06 | 2024-01-11 | |
| 129 | IL-12 Variants and Uses Thereof Related Patents View Abstract: IL-12 variants are provided. Also provided are antibodies that specifically bind to PD1. Also provided are fusion proteins of IL-12 variants and anti-PD1 antibodies. Also provided … |
PFIZER | 2023-06-15 | 2024-01-11 | |
| 130 | COMBINATION PRODUCT FOR THE TREATMENT OF CANCER Related Patents View Abstract: Methods of administering a therapeutically effective amount of Debio 1143 and a therapeutically effective amount of an anti-PD-L1 antibody or antigen-binding fragment thereof, for … |
DEBIOPHARM INTERNATIONAL; MERCK PATENT; PFIZER | 2023-06-02 | 2024-01-11 | |
| 131 | METHODS AND COMPOSITIONS FOR INHIBITING EXCESS NUCLEIC ACID PRECIPITATION Related Patents View Abstract: The present disclosure provides improved methods and systems for transfecting host cells with nucleic acids, such as plasmid DNA, for purposes of efficiently producing biological … |
PFIZER | 2021-12-17 | 2024-01-11 | |
| 132 | METHODS AND COMPOSITIONS FOR INHIBITING EXCESS NUCLEIC ACID PRECIPITATION Related Patents View Abstract: The present disclosure describes improved methods for use in purifying biological products made by host cells. In some embodiments, the improved methods comprise one or more steps … |
PFIZER | 2021-12-17 | 2024-01-11 | |
| 133 | 3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS Related Patents View Abstract: The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form … |
PFIZER | 2023-09-18 | 2024-01-04 | |
| 134 | CELL CULTURE PROCESS Related Patents View Abstract: A cell culture medium comprising tyrosine at a concentration of at least 3 mM and polyvinylalcohol (PVA). … |
PFIZER | 2023-08-31 | 2023-12-28 | |
| 135 | NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS THEREOF Related Patents View Abstract: In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a non-serogroup B capsular polysaccharide. The invention further relates to … |
PFIZER | 2023-06-29 | 2023-12-28 | |
| 136 | TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF Related Patents View Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful … |
PFIZER | 2023-03-13 | 2023-12-28 | |
| 137 | ANTI-TNFR2 ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The present disclosure provides antibodies that bind to TNFR2 as well as uses of the antibodies and associated methods. The disclosure also provides processes for making, … |
PFIZER | 2023-05-25 | 2023-12-21 | |
| 138 | SOLID STATE FORMS OF (S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE AND USES THEREOF Related Patents View Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of … |
PFIZER | 2023-01-20 | 2023-12-21 | |
| 139 | SOLID STATE FORMS OF (S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE AND USES THEREOF Citation: 2 Related Patents View Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of … |
PFIZER | 2023-07-28 | 2023-11-30 | |
| 140 | Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes) Related Patents View Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and … |
PFIZER | 2023-07-24 | 2023-11-30 | |
| 141 | Chemical Compounds Related Patents View Abstract: The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such … |
PFIZER | 2023-05-24 | 2023-11-30 | |
| 142 | ANTI-LYMPHOTOXIN BETA RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: Antibodies that specifically bind to LTBR are provided. Also provided are uses of these antibodies, and related compositions and methods. … |
PFIZER | 2023-05-10 | 2023-11-16 | |
| 143 | GLYCOCONJUGATION PROCESSES AND COMPOSITIONS Related Patents View Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, … |
PFIZER | 2023-06-21 | 2023-11-09 | |
| 144 | ANTIBODIES AND ANTIBODY-DRUG CONJUGATES SPECIFIC FOR CD123 AND USES THEREOF Related Patents View Abstract: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising … |
PFIZER | 2023-03-08 | 2023-11-09 | |
| 145 | GROUP B STREPTOCOCCUS POLYSACCHARIDE-PROTEIN CONJUGATES, METHODS FOR PRODUCING CONJUGATES, IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATES, AND USES THEREOF Related Patents View Abstract: The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from , commonly referred to as group B streptococcus (GBS), and a … |
PFIZER | 2022-12-01 | 2023-11-02 | |
| 146 | Bicyclic-Fused Heteroaryl or Aryl Compounds Related Patents View Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. … |
PFIZER | 2023-06-28 | 2023-10-26 | |
| 147 | ANTIBODIES SPECIFIC FOR GUCY2C AND USES THEREOF Related Patents View Abstract: The present invention provides novel antibodies that specifically bind to GUCY2c and uses thereof in the treatment of cancer. The present invention further provides novel … |
PFIZER | 2022-10-27 | 2023-10-26 | |
| 148 | ANTI-IL-2 ANTIBODIES AND COMPOSITIONS AND USES THEREOF Related Patents View Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The … |
PFIZER; REGENTS OF THE UNIVERSITY OF CALIFORNIA; BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-09-16 | 2023-10-26 | |
| 149 | N1-Pyrazolospiroketone Acetyl-CoA Carboxylase Inhibitors Related Patents View Abstract: The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R , R , R , Z, A , L and A are as described herein; pharmaceutical … |
PFIZER | 2023-05-03 | 2023-10-12 | |
| 150 | METHODS, DOSAGE REGIMENS, AND COMPOSITIONS FOR TREATING HIDRADENITIS Related Patents View Abstract: There are methods, dosage regimens, and compositions for treating hidradenitis suppurativa. … |
PFIZER | 2023-03-08 | 2023-09-21 | |
| 151 | DLL3 TARGETING CHIMERIC ANTIGEN RECEPTORS AND BINDING AGENTS Related Patents View Abstract: Provided herein are DLL3 binding agents and chimeric antigen receptors (CARs) comprising a DLL3 binding molecule that specifically binds to DLL3; and immune cells comprising these … |
ALLOGENE THERAPEUTICS et. al. | 2023-04-27 | 2023-09-14 | |
| 152 | Benzimidazole Derivative Compounds and Uses Thereof Related Patents View Abstract: The invention relates to benzimidazoles of Formula (1) and pharmaceutically acceptable salts thereof, wherein R to R are as defined in the description; to their use in medicine; … |
PFIZER | 2023-04-17 | 2023-09-07 | |
| 153 | COMBINATION OF AN ANTI-PD-L1 ANTIBODY AND A DNA-PK INHIBITOR FOR THE TREATMENT OF CANCER Related Patents View Abstract: The present invention relates to combination therapies useful for the treatment of cancer. In particular, the invention relates to a therapeutic combination which comprises an … |
MERCK PATENT et. al. | 2022-12-23 | 2023-08-31 | |
| 154 | ANTI-EDB ANTIBODIES AND ANTIBODY-DRUG CONJUGATES Related Patents View Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same. … |
PFIZER | 2023-02-09 | 2023-08-03 | |
| 155 | RNA MOLECULES Related Patents View Abstract: The present disclosure relates to RNA molecules encoding a varicella zoster virus (VZV). The present disclosure further relates to compositions comprising the RNA molecules … |
PFIZER | 2022-10-12 | 2023-07-27 | |
| 156 | RSV F Protein Mutants Related Patents View Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, … |
PFIZER | 2023-03-29 | 2023-07-13 | |
| 157 | PHARMACEUTICAL AQUEOUS FORMULATION COMPRISING 1-(4-{[4-(DIMETHYLAMINO)PIPERIDIN-1-YL]CARBONYL}PHENYL)-3-[4-(4,6-DIMORPHOLIN-4-YL-1,3,5-TRIAZIN-2-YL)PHENYL]UREA Citation: 1 Related Patents View Abstract: The present invention relates to a pharmaceutical aqueous formulation comprising … |
PFIZER | 2022-11-30 | 2023-07-13 | |
| 158 | GLYCOCONJUGATION PROCESS Related Patents View Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related … |
PFIZER | 2023-03-01 | 2023-06-29 | |
| 159 | SOLID STATE FORMS OF (S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE AND USES THEREOF Citation: 2 Related Patents View Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of … |
PFIZER | 2023-02-17 | 2023-06-29 | |
| 160 | 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES Related Patents View Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R , R , L, … |
PFIZER | 2023-02-21 | 2023-06-22 | |
| 161 | SOLID FORMS OF PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS Related Patents View Abstract: The present disclosure provides solid forms of … |
PFIZER | 2022-12-16 | 2023-06-22 | |
| 162 | PIPERAZINE AZASPIRO DERIVATIVES Related Patents View Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: X , X , R , … |
PFIZER | 2022-10-19 | 2023-06-22 | |
| 163 | IMMUNOGENIC COMPOSITIONS FOR USE IN PNEUMOCOCCAL VACCINES Related Patents View Abstract: An object of the present invention is to provide immunogenic compositions for protection against , in particular against serogroup 18, while limiting the number of conjugates. … |
PFIZER | 2022-07-15 | 2023-06-22 | |
| 164 | METHODS FOR ANTAGONIZING A MELANOCORTIN 4 RECEPTOR Related Patents View Abstract: Described herein are methods of treating MC4R-related conditions, diseases, or disorders by administering compounds of Formula I: … |
PFIZER | 2023-01-31 | 2023-06-08 | |
| 165 | Benzisoxazole Sulfonamide Derivatives Related Patents View Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, R -R , and n are defined herein. The novel benzisoxazole … |
PFIZER et. al. | 2022-09-16 | 2023-06-08 | |
| 166 | SOLID STATE FORMS OF (S)-2-(((S)-6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)AMINO)-N-(1-(2-METHYL-1-(NEOPENTYLAMINO)PROPAN-2-YL)-1H-IMIDAZOL-4-YL)PENTANAMIDE AND USES THEREOF Related Patents View Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of … |
PFIZER | 2023-01-27 | 2023-06-01 | |
| 167 | BCKDK INHIBITORS AND/OR DEGRADERS Related Patents View Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors and/or … |
PFIZER | 2022-11-30 | 2023-06-01 | |
| 168 | Boron Containing PDE4 Inhibitors Related Patents View Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses … |
PFIZER | 2022-12-15 | 2023-05-11 | |
| 169 | TRICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS Related Patents View Abstract: The present invention is directed to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents A, R , R , R , R , R , R and n are as defined … |
PFIZER | 2022-10-12 | 2023-05-11 | |
| 170 | 3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS Related Patents View Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R , R , R and R are as defined herein. The invention further relates to … |
PFIZER | 2022-12-01 | 2023-04-20 | |
| 171 | GLP-1 RECEPTOR AGONISTS AND USES THEREOF Citation: 1 Related Patents View Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods … |
PFIZER | 2022-10-24 | 2023-04-20 | |
| 172 | Nitrile-Containing Antiviral Compounds Related Patents View Abstract: The invention relates to compounds of Formula I″ wherein R, R , R , R , p, q and q′ are as defined herein, pharmaceutical compositions comprising the compounds, methods of … |
PFIZER | 2022-09-14 | 2023-04-20 | |
| 173 | COMPOSITIONS AND METHODS FOR TREATMENT OF ABNORMAL CELL GROWTH Related Patents View Abstract: This invention relates to oral dosage forms and methods that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans. … |
VERASTEM et. al. | 2022-06-10 | 2023-04-06 | |
| 174 | ANTIBODIES SPECIFIC FOR FLT3 AND THEIR USES Citation: 1 Related Patents View Abstract: The present invention provides antibodies that specifically bind to FLT3 (Fms-Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and … |
PFIZER | 2022-06-24 | 2023-02-23 | |
| 175 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES Related Patents View Abstract: A compound compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable … |
PFIZER | 2022-09-07 | 2023-02-09 | |
| 176 | CHIMERIC ANTIGEN RECEPTORS TARGETING CD70 Related Patents View Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and … |
PFIZER | 2022-06-17 | 2023-02-09 | |
| 177 | TRICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS Related Patents View Abstract: The present invention is directed to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents A, R , R , R , R , R , R and n are as defined … |
PFIZER | 2022-08-12 | 2023-01-05 | |
| 178 | ANTIBODIES SPECIFIC FOR CD70 AND THEIR USES Related Patents View Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 … |
PFIZER | 2022-06-01 | 2023-01-05 | |
| 179 | TUMOR NECROSIS FACTOR-LIKE LIGAND 1A SPECIFIC ANTIBODIES AND COMPOSITIONS AND USES THEREOF Related Patents View Abstract: The present invention provides antibodies, or antigen-binding fragment thereof, which specifically bind to tumor necrosis factor (TNF)-like ligand (TL1A). The invention further … |
PFIZER; BRISTOL-MYERS SQUIBB | 2022-07-28 | 2022-12-08 | |
| 180 | IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATED CAPSULAR SACCHARIDE ANTIGENS AND USES THEREOF Related Patents View Abstract: The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof. … |
PFIZER | 2022-05-25 | 2022-12-08 | |
| 181 | IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATED CAPSULAR SACCHARIDE ANTIGENS AND USES THEREOF Related Patents View Abstract: The present invention relates to new conjugated capsular saccharide antigens (glycoconjugates), immunogenic compositions comprising said glycoconjugates and uses thereof. … |
PFIZER | 2022-05-25 | 2022-12-08 | |
| 182 | ANTI-GDF15 ANTIBODIES, COMPOSITIONS AND METHODS OF USE Related Patents View Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies. … |
PFIZER | 2022-08-01 | 2022-12-01 | |
| 183 | STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDES AND CONJUGATES THEREOF Related Patents View Abstract: The invention relates to activated serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising … |
PFIZER | 2022-07-22 | 2022-12-01 | |
| 184 | IMMUNOGENIC COMPOSITION AGAINST INFLUENZA Citation: 1 Related Patents View Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one … |
PFIZER | 2022-04-29 | 2022-11-17 | |
| 185 | CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN Related Patents View Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, … |
PFIZER | 2022-03-15 | 2022-10-27 | |
| 186 | CDK2/4/6 Inhibitors Related Patents View Abstract: This invention relates to compounds of general Formula (I) … |
PFIZER | 2022-06-15 | 2022-10-13 | |
| 187 | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR INHIBITOR FOR TREATING CANCER Related Patents View Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a VEGFR inhibitor, and the use of the combination … |
PFIZER; MERCK | 2022-04-20 | 2022-10-13 | |
| 188 | 3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS Related Patents View Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R , R , R and R are as defined herein. The invention further relates to … |
PFIZER | 2022-03-30 | 2022-10-13 | |
| 189 | Modulators of STING (Stimulator of Interferon Genes) Related Patents View Abstract: Provided herein are compounds of the general formula (I): and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing … |
PFIZER | 2022-03-11 | 2022-09-29 | |
| 190 | ANTI-AVBETA8 ANTIBODIES AND COMPOSITIONS AND USES THEREOF Related Patents View Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to αvβ8 integrin. The invention includes uses, and associated methods of using the … |
PFIZER; REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-05-13 | 2022-09-15 | |
| 191 | TOLL-LIKE RECEPTOR AGONISTS Related Patents View Abstract: The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, … |
PFIZER | 2022-05-06 | 2022-09-01 | |
| 192 | Nitrile-Containing Antiviral Compounds Related Patents View Abstract: The invention relates to compounds of Formula I″ wherein R, R , R , R , p, q and q′ are as defined herein, pharmaceutical compositions comprising the compounds, methods of … |
PFIZER | 2022-04-22 | 2022-08-18 | |
| 193 | CHIMERIC ANTIGEN RECEPTORS TARGETING EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III Related Patents View Abstract: The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to … |
PFIZER | 2022-01-27 | 2022-07-21 | |
| 194 | PROTEASE-ACTIVATING CD45-GATE CAR Related Patents View Abstract: A reversibly gated effector polypeptide e.g. a chimeric antigen receptor (protease-activating CD45-gate CAR) comprising an extracellular CD45 recruiting domain, a … |
ALLOGENE THERAPEUTICS et. al. | 2021-12-21 | 2022-07-21 | |
| 195 | DOSING REGIMEN OF AVELUMAB FOR THE TREATMENT OF CANCER Related Patents View Abstract: The present invention relates to dosing regimen of avelumab for the treatment of cancer. In particular, the invention relates to improved dosing regimen of avelumab for the … |
PFIZER et. al. | 2022-02-09 | 2022-07-14 | |
| 196 | E. COLI FIMH MUTANTS AND USES THEREOF Citation: 2 Related Patents View Abstract: This disclosure relates to the design of mutated FimH polypeptides that result in improved biochemical properties and immunogenicity, compositions comprising such polypeptides, … |
PFIZER | 2021-12-17 | 2022-06-30 | |
| 197 | ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF Citation: 1 Related Patents View Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from lipopolysaccharides and conjugates thereof. … |
PFIZER | 2022-02-15 | 2022-06-02 | |
| 198 | TOFACITINIB ORAL SUSTAINED RELEASE DOSAGE FORMS Citation: 1 Related Patents View Abstract: The present invention relates to oral sustained release formulations of tofacitinib and pharmaceutical acceptable salts thereof. The formulations described herein have desirable … |
PFIZER | 2022-01-21 | 2022-05-12 | |
| 199 | Nitrile-Containing Antiviral Compounds Related Patents View Abstract: The invention relates to compounds of Formula I″ wherein R, R , R , R , p, q and q′ are as defined herein, pharmaceutical compositions comprising the compounds, methods of … |
PFIZER | 2021-12-17 | 2022-05-12 | |
| 200 | MANUFACTURING PROCESS AND INTERMEDIATES FOR A PYRROLO[2,3-D]PYRIMIDINE COMPOUND AND USE THEREOF Related Patents View Abstract: The present invention relates to a manufacturing process and intermediates for preparing a crystalline or non-crystalline form of … |
PFIZER | 2022-01-10 | 2022-04-28 |