Clinical Digest: Recent Clinical Trials on Salmonella
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Salmonella. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Salmonella
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Effect of Aquatic Exercises on Muscle Strength and Quality of Life in Children With Sickle Cell Anemia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sickle cell anemia is a global public health disorder that affects millions of people across the globe. It is an inherited autosomal recessive hemoglobin condition caused by a beta-globin gene mutation that results in an aberrant sickle cell hemoglobin molecule with glutamic acid replaced by valine at position six of the beta-globin chain. Sickle cell anemia is a hereditary illness characterized by persistent microvascular blockage by sickle-shaped cells, chronic hemolytic anemia, and tissue destruction. Red-cell dehydration, hypoxemia, metabolic acidosis, and hyperthermia are typical vaso-occlusive triggers. Children with sickle cell anemia frequently have poor growth and nutritional status, increased protein turnover, … |
EMAN SAMIR SHALTOUT; | 2025-05-01 |
| 2 | Evaluation of Typhoid Conjugate Vaccine (TCV) Effectiveness Among Bangladeshi Children Using The Test-negative Design PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective closed cohort, open-label, phase III effectiveness study using a test-negative design of a typhoid conjugate vaccine, ZyVac® TCV (purified Vi capsular polysaccharide of Salmonella Typhi conjugated to tetanus toxoid as carrier protein), manufactured by Zydus Lifesciences Limited. The study will be conducted in a closed cohort population among children aged 6 months to 15 years residing in wards 5, 6, 7, 48, 49, 50, 63, 71, … |
INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH | 2025-04-01 |
| 3 | Long-Term Protection of Vi Antibodies Induced By Vi-DT Conjugate Vaccines (Bio TCV) in Indonesian Population Compared to PQed TCV PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Typhoid fever is a serious systemic infection caused by the enteric pathogen Salmonella enterica serovar typhi. S typhi is spread by the fecal-oral route. Although largely an endemic disease, S. typhi has epidemic potential. This research aims to determine the long-term immune response after administration of one dose of Bio TCV and PQed TCV vaccines in the population in Indonesia. Research participants will be taken from research participants who complete the Bio TCV (Typhoid 0319) Phase III clinical trial research included in the Main Study Group I. |
PT BIO FARMA | 2025-04-01 |
| 4 | Can A Patient in Intensive Care Be Visited By His or Her Pet? Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Nearly half of all intensive care patients describe symptoms of anxiety and depression after a stay in the ICU, and one in five has genuine post-traumatic stress disorder. As a result, improving patient experience has become a priority in the ICU, and particular attention is being paid to the need to recreate a familiar environment. Animal-mediated interventions have been developed for a number of patients over many years. These strategies are widely used with elderly patients, and patients with cognitive or psychiatric disorders, for whom the literature shows benefits on anxiety, … |
CINDY POKRANDT; | 2025-04-01 |
| 5 | An Open-Label, Dose-Escalation Clinical Trial to Evaluate The Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy of YB1-X7 Injection in Subjects with Advanced Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial is an open-label, dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetic, and preliminary efficacy of YB1-X7 injection in subjects with advanced solid tumors. YB1-X7 injection is an attenuated Salmonella-based tumor therapy. It selectively accumulates in hypoxic tumor regions while being rapidly cleared from normal organs. After proliferating in the tumor microenvironment, YB1-X7 invades tumor cells and releases its therapeutic payload, leading to tumor cell death and tumor regression. Conditions：To treat subjects with advanced and/or metastatic solid tumors who do not to respond to conventional standard treatment or who lack effective standard treatment. |
SHANGHAI SALVECTORS BIOTECHNOLOGY | 2025-03-15 |
| 6 | Multi-component Chlorination Intervention to Reduce Neonatal Infections in Rural Health Facilities PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The CLEAN (ChLorine to reduce Enteric and Antibiotic resistant infections in Neonates) cluster randomized controlled trial in western Kenya will evaluate the impact of a multi-component chlorination intervention in health care facilities on maternal and neonatal health. Intervention facilities will receive a passive chlorination technology for water supply treatment and a reliable supply of sodium hypochlorite disinfectant. Both intervention and treatment facilities will receive infection prevention and control messaging. The goal of the study is to evaluate the impact of the intervention on bacterial contamination of water supply, on staff hands, and on high-touch surfaces in maternity wards, … |
AMY J PICKERING; | 2025-01-21 |
| 7 | Association of Helicobacter Pylori Infection With Disease Activity in Systemic Lupus Erythrematosis and Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To find the relation of Helicobacter pylori with disease activity in SLE and RA |
FATMA MOSTAFA MOHAMED AHMED; | 2024-09-04 |
| 8 | Fecal Transplantation in Patients With Colonic Diverticulitis: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the safety and effect of fecal microbiome transplantation (FMT) in patients with a former episode of acute colonic diverticulitis. The main question[s] it aims to answer are: – Is FMT in patients with a former episode of acute colonic diverticulitis a safe procedure without severe adverse events – What is the impact of FMT on patient-reported outcomes and re-admission rate Participants will be asked to: – to ingest either 25-30 capsules with FMT or placebo capsules – Fill-in GI-QLI questionnaire prior to treatment/placebo and 3 months post baseline – … |
THOMAS BJØRSUM-MEYER; | 2024-04-01 |
| 9 | Ability of The Probiotic Vivomixx to Improve Environmental Enteropathy in Pregnant Women: A Proof of Concept Trial in Bangladesh, Pakistan, Senegal and Zambia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial will determine if a well-established probiotic, Vivomixx, can modulate maternal microbiota and ameliorate maternal environmental enteropathy which compromises growth in the first 1000 days. The probiotic Vivomixx has been used in many thousands of people including pregnant women, both within and outside a research context. This trial is the first in a proposed series of proof-of-concept intervention studies which are intended to provide data to enable a rational selection of interventions to be evaluated at scale in future large scale trials in which birth outcomes and postnatal growth will be key endpoints. |
S. M. TAFSIR HASAN; | 2023-06-22 |
| 10 | A Phase I/IIa, Open-label, Dose Escalation and Dose-Expansion Study to Evaluate The Safety and Tolerability of Modified Salmonella Typhimurium SGN1 Administered Via Intratumoral Injection in Patients With Advanced Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: To characterize safety, tolerability, MTD and OBD of intratumoral injection of SGN1 in patients with advanced solid tumors, and to preliminarily investigate the efficacy and safety of SGN1 in specific tumor subtypes. Study Rationale: The mechanism of action for SGN1 is based on the fact that most tumors are methionine dependent. SGN1 is designed to be used as a tumor therapeutic bacterium that can preferentially replicate and accumulate in tumors and starve them of essential amino acids by delivering the oncolytic enzyme L-Methioninase. Patient Population: Patients presenting with histologically confirmed advanced and/or metastatic solid tumors that are refractory to standard therapy and for which no other conventional therapy exists. |
GUANGZHOU SINOGEN PHARMACEUTICAL | 2023-04-19 |
| 11 | A Randomized Controlled Trial Comparing Nifuroxazide Plus Lactulose With Lactulose Alone in The Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluating the efficacy and safety of the efficacy and safety of nifuroxazide in combination with lactulose in comparison to lactulose alone in the treatment of hepatic encephalopathy in patients with grade II-III hepatic encephalopathy |
MENNAT ALLAH SAEID EMAM; | 2023-03-12 |
| 12 | Phase I/IIa, Open-label Study to Evaluate Safety, Tolerability and Preliminary Efficacy of Modified Salmonella Typhimurium SGN1 in Patients With Advanced Solid Tumor PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives:To assess the safety and tolerability followed by a dose expansion study to characterize safety, and preliminary efficacy of SGN1 in participants with refractory solid tumors. Study Rationale:The mechanism of action for SGN1 is based on the fact that most tumors are methionine dependent. SGN1 is designed to be used as a tumor therapeutic bacterium that can preferentially replicate and accumulate in tumors and starve them of essential amino acids by delivering the oncolytic enzyme L-Methioninase. Patient Population:The treatment populations shall be patients presenting with histologically confirmed advanced and/or metastatic solid tumors that are refractory to standard therapy and for which no other conventional therapy exists. |
GUANGZHOU SINOGEN PHARMACEUTICAL | 2023-01-16 |
| 13 | Azithromycine Pour La Vie Des Enfants Au Niger – Implémentation Et Recherche: Essai Mortalité Et Résistance (Azithromycin for Child Survival in Niger: Programmatic Trial) PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The MORDOR trial found that biannual distribution of azithromycin to children 1-59 months old reduced child mortality. The World Health Organization (WHO) released conditional guidelines for this intervention, which include targeting azithromycin distributions to children 1-11 months of age in high mortality settings. The proposed trial aims to demonstrate and evaluate large-scale implementation of azithromycin to children aged 1-11 months old in the context of a programmatic setting while monitoring mortality and resistance antimicrobial resistance. |
KIERAN O’BRIEN; | 2022-12-01 |
| 14 | Ability of The Probiotic Vivomixx to Improve Environmental Enteropathy in Pregnant Women: A Proof of Concept Trial in Senegal PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stunting in young children refers to attenuated linear growth. In the year 2020, 149.2 million children under the age of 5 were stunted, accounting for 22% of stunting globally. Stunting has short- and long-term consequences of increased morbidity and mortality, impairment of neurocognitive development , impaired responses to oral vaccines, and increased risk of non-communicable diseases. Stunting is partly driven by Environmental Enteric Dysfunction (EED), an enteropathic condition characterised by altered gut permeability, … |
YAKHYA DIEYE; | 2022-12-01 |
| 15 | Ability of The Probiotic Vivomixx to Improve Environmental Enteropathy in Pregnant Women: A Proof of Concept Trial in Bangladesh, Pakistan, Senegal and Zambia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial will determine if a well-established probiotic, Vivomixx, can modulate the maternal microbiota and ameliorate the maternal environmental enteropathy which compromises growth in the first 1000 days. The probiotic Vivomixx has been used in many thousands of people including pregnant women, both within and outside a research context. This trial is the first in a proposed series of proof-of-concept intervention studies which are intended to provide data to enable a rational selection of interventions to be evaluated at scale in future large scale phase 2 trial in which birth outcomes and postnatal growth will be key endpoints. |
PAUL KELLY; | 2022-12-01 |
| 16 | A Phase 1, Observer-blind, Randomised, Controlled, Single-centre Study to Evaluate The Safety, Reactogenicity, and Immune Responses to An Adjuvanted and Non-adjuvanted Conjugate Vaccine Against Salmonella Typhi and Salmonella Paratyphi A in Healthy Adults 18 to 50 Years of Age in Europe PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A bivalent Typhoid and Paratyphoid A conjugate investigational vaccine aimed to prevent both typhoid and paratyphoid enteric fever in infants and older age groups has been developed by GlaxoSmithKline (GSK). The purpose of this first-time-in-human study is to evaluate the safety and immunogenicity profile of a low and a full dose of the investigational vaccine, formulated with or without adjuvant, administered in 2 doses, 24 weeks apart, in healthy adults 18 to 50 years of age in Europe. |
GLAXOSMITHKLINE | 2022-11-08 |
| 17 | A Randomized Controlled, Open Labeled, Two Arm, Study of Addition of Everolimus to Standard of Care in Carcinoma Gallbladder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Gallbladder cancer (GBC) is the most common malignant tumour of the biliary tract. It is also the most aggressive cancer of the biliary tract with the shortest median survival from the time of diagnosis. Currently, radical resection is the most effective strategy to potentially cure GBC. Chemotherapy and radiotherapy have been employed as adjuvant and palliative setting, however, the overall survival is still dismal. This study aim to evaluate the addition of Everolimus in addition to standard of care in gallbladder cancer. |
MANOJ PANDEY; | 2022-11-01 |
| 18 | WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if adding dietary fiber, such as inulin, to a diet that does not have enough fiber would raise the levels of potentially beneficial bacteria, such as Bifidobacterium, in the gut. There is evidence to suggest that these microbes can affect gut health and immune response, including to vaccines. The investigators will examine how inulin in the diet (compared to the maltodextrin control) (1) causes changes in the composition and function of the gut microbes, (2) reduces gut inflammation and gut leakiness caused by the vaccine, (3) increases immune response to vaccination, … |
DANIELLE LEMAY; | 2022-09-27 |
| 19 | Evaluation of DPP® Typhoid Assay (Chembio Diagnostic System, Inc) for The Diagnosis of Typhoid From Well Characterized Serum Sample PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Fever management is a major problem in Low and Middle Income Countries (LMICs) where access to good quality diagnostic test is often unavailable. Fever due to typhoid is similar to other undifferentiated febrile illnesses and typhoid can be mistaken with other vector borne febrile illnesses such as scrub typhus. Currently available diagnostic tests, blood and bone marrow culture, and RDTs have several limitations including a low sensitivity and specificity . Recently, … |
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS SWITZERLAND | 2022-09-15 |
| 20 | A Phase 1/2a, Observer-blind, Randomized, Controlled, Two-stage, Multi-country Study to Evaluate The Safety, Reactogenicity, and Immune Response of The Trivalent Vaccine Against Invasive Nontyphoidal Salmonella (iNTS) and Typhoid Fever in Healthy European and African Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety, reactogenicity, and immune response induced by the GlaxoSmithKline Biologicals SA (GSK) Vaccines Institute for Global Health (GVGH) invasive nontyphoidal Salmonella-typhoid conjugate (iNTS-TCV) candidate vaccine to be administered for the first time in humans. The study intervention will be evaluated in European adults in Stage 1 (a 2-step staggered design) followed by African adults in Stage 2. |
KANCHANAMALA WITHANAGE; | 2022-09-13 |
| 21 | Phase 1 Randomized, Placebo-Controlled, Study to Compare The Safety, Reactogenicity, and Immunogenicity of A Full-Strength Formulation of Trivalent Salmonella (S. Enteritidis/S. Typhimurium/S. Typhi Vi) Conjugate Vaccine (TSCV), A Half-Strength Formulation of TSCV, and A Dilutional Half-Strength Dose of TSCV Against Invasive Salmonella Disease Administered Parenterally to Healthy U.S. Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, placebo-controlled interventional study. The main purpose of this research is to test the safety and measure the immune response of the trivalent vaccine against invasive Salmonella disease. The vaccine will be tested over a range of doses. |
WILBUR CHEN; | 2022-08-15 |
| 22 | Research of Change of Microbial System Intestines and Efficacy for Probiotic Treatment of Persistent Diarrhea in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Persistent diarrhea is a common health problem worldwide, particularly in low-income countries. According to the WHO, approximately 3% to 20% of acute diarrhea episodes in children under 5 years of age become persistent diarrhea. Persistent diarrhea causes malnutrition, weight loss, and dehydration, as well as increasing treatment costs and the risk of mortality. One of the main causes of persistent diarrhea is the overgrowth and spread of bacteria, as well as viral infections that can disrupt the balance of microorganisms in the gut. Antibiotics are effective in treating bacterial infections that cause persistent diarrhea in children, … |
HA DANG THUY; | 2022-07-01 |
| 23 | Optimisation De L’Usage D’Antibiotiques Et Contrôle Des Infections Au Niveau Communautaire Par Un Paquet D’Interventions Ciblant Le Comportement Au Burkina Faso Et En République Démocratique Du Congo PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Emergence of antibiotic resistance (AMR) is a serious concern for Low and Middle Income Countries (LMICs). Unregulated use of antibiotics, a major AMR driver, is highly prevalent in LMICs, with medicine stores as key providers. Physical interactions between One Health compartments increase cross-domain transmission risks, although the relative importance of different reservoirs is uncertain, with community-level dynamics of AMR in LMICs largely unquantified. In two rural health districts in Burkina Faso and DR Congo, a behavioural intervention bundle will be developed, targeting medicine stores and their communities, to optimise antibiotic use and improve hygiene, … |
MARIANNE AB VAN DER SANDE; | 2022-05-18 |
| 24 | Development and Evaluation of An Electronic Algorithm Using A Combination of A Two-step Malaria RDT, and Other Rapid Diagnostic Tools for The Management of Febrile Illness in Children Under 5 Attending Outpatient Facilities in Burkina Faso PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In Sub-Saharan Africa (SSA), fever remains a major public health problem in children. The introduction of malaria rapid diagnostic tests (RDTs) in routine healthcare has greatly improved the management of malaria. However, despite the good attitude of healthcare workers to adhere to malaria RDT test results, persisting hrp2antigen and low sensitivity of pLDH RDT negatively affect antimalarials and antibiotics prescriptions practices. This is one of the main causes of antimicrobial resistance (AMR) and inappropriate management of febrile diseases. To improve the diagnosis of febrile diseases and subsequent prescription of antimicrobials, … |
INSTITUT DE RECHERCHE EN SCIENCES DE LA SANTE BURKINA FASO | 2022-02-28 |
| 25 | Persistent Readiness Through Early Prediction Immunization Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will enroll volunteers in an open-format (outside hospital) setting, to complete novel data collection/analysis of biomarkers, facial images, and audio-recording to establish an optimal set of parameters to predict emergent cases of infection via an early warning score, along with actionable personalized information. |
MARIELLE PKJ ENGELEN; | 2022-02-08 |
| 26 | An Open-label Effectiveness Study of A Typhoid Conjugate Vaccine in Kisantu, Democratic Republic of Congo (TyVECO) – Step 2: Typhoid Conjugate Vaccine (TCV) Mass-vaccination Campaign PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective cohort evaluation of vaccine effectiveness of a single dose of Typbar-TCV® against symptomatic blood culture-confirmed typhoid fever when administered through a mass vaccination campaign to children 9 months to <16 years of age in Kisantu, DRC. |
FLORIAN MARKS; | 2022-01-01 |
| 27 | Serum Levels of Interleukins 6 and 8 in Malnourished Children With Acute Diarrhea PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cytokines, such as IL-6 and IL-8 can be used as markers of acute infections, including acute gastroenteritis. However, there have been no previous studies on the levels of IL-6 and IL-8 in malnourished children with acute diarrhea. This study aims to evaluate serum levels of interleukins 6 and 8 in malnourished children with acute diarrhea. |
MOTAZ MOHAMED HASSAN; | 2022-01-01 |
| 28 | An Open-label Effectiveness Study of A Typhoid Conjugate Vaccine in Kisantu, Democratic Republic of Congo (TyVECO) – Step 3: Surveillance Protocol PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: In Kisantu Health Zone, approximate population 200,000, fever surveillance will be implemented in 8 health centers and 1 tertiary hospital. Individuals presenting to one of these study facilities with acute fever or history of fever or individuals presenting with suspicion of intestinal perforation irrespective of fever status, will be considered for enrollment. Following consent, … |
INTERNATIONAL VACCINE INSTITUTE | 2021-08-09 |
| 29 | Multiple Myeloma Trial of Orally Administered Salmonella Based Survivin Vaccine Related Papers Related Patents Related Grants Related Experts View Highlight: Multiple myeloma patients will receive a cancer vaccine, called TXSVN that has been derived from the bacteria Salmonella. TXSVN is a weakened form of a live vaccine strain of the Salmonella bacteria (also known as the CVD908ssb strain) that has been genetically modified in the laboratory to produce a protein known as Survivin that stimulates an immune response in the body to the Survivin tumor antigen. CVD908ssb has been administered to over 80 healthy donors as a Salmonella vaccine in reported clinical trials. This trial intends to explore administration of this vaccine at a lower dose than what was tested in healthy individuals. Survivin belongs to the group of proteins known as tumor-associated antigens (TAAs). These are cell proteins that are specific to the cancer cell. They either are not found or are found in low levels normal cells in the human body. More than 90% of myeloma cancer cells have been shown to possess large quantities of Survivin. TXSVN may activate the immune system which is your body’s ability to fight disease, and help develop a response against cancer cells that express Survivin. Survivin has been safely targeted using immune cells, drugs or direct inhibitors in over 50 patients with cancers in published reports. TXSVN, the modified strain of CVD908ssb has not been tested in humans to this date. TXSVN is an investigational product not approved by the U.S. Food and Drug Administration. The purpose of this study is to find the largest safe dose of TXSVN, to learn what the side effects are, and to see whether this therapy might help participants with multiple myeloma. |
PREMAL LULLA; | 2021-08-06 |
| 30 | Treating Non-typhoidal Salmonella Bloodstream Infections in Children Under Five in DR Congo: A Cohort Study – TreNTS PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: With this study the researchers aim to provide observational data on the treatment efficacy of currently used antibiotic treatment regimens for NTS BSI in hospital-admitted children. The study is an observational cohort study where the antibiotic treatments used and treatment outcomes in the St. Luc general referral hospital in Kisantu health zone (Province Kongo Central, DR Congo) will be described. |
BIEKE TACK; | 2021-08-01 |
| 31 | The Potential Protective Effect of A Formula Supplemented With Fermented Matrices on The Risk of Developing Neonatal Sepsis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo controlled trial, with parallel groups and reference group. The aim of the study was to evaluate the hypothesis that an immunonutritional strategy, based on use of Lactobacillus paracasei CBA L74-fermented formula, prevents or limits the development of late-onset-sepsis in preterm infants. |
HEINZ ITALIA SPA | 2021-03-01 |
| 32 | Clinical Decision Support in Non-typhoidal Salmonella Bloodstream Infections in Children in Sub-Saharan Africa: A Prospective Cohort Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In sub-Saharan Africa, non-typhoidal Salmonella (NTS) are a frequent cause of bloodstream infection, display high levels of antibiotic resistance and have a high case fatality rate (15%). In Kisantu hospital in the Democratic Republic of Congo (DR Congo), NTS account for 75% of bloodstream infection in children and many children are co-infected with Plasmodium falciparum (Pf) malaria. NTS bloodstream infection presents as a non-specific severe febrile illness, which challenges early diagnosis and, as a consequence, prompt and appropriate antibiotic treatment.Moreover, at the first level of care, frontline health workers have limited expertise and diagnostic skills and, as a consequence, … |
BIEKE TACK; | 2021-02-01 |
| 33 | Health Itinerary of Young Children With Suspected Bloodstream Infection in Kisantu General Referral Hospital, DR Congo: A Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Bloodstream infections are frequent in children admitted to the hospital for severe febrile illness in sub-Saharan Africa.Ongoing blood culture surveillance at Kisantu Hospital showed non-typhoidal Salmonella (NTS) as the first cause of bloodstream infections in children. Bloodstream infections have a high case fatality (15 – 20%). Outcome of bloodstream infections is dependent on timely diagnosis and treatment. However, observations at Kisantu Hospital showed that many children arrive late and die early after admission. By interviewing caregivers of severely ill children admitted to Kisantu Hospital, the investigators aim to study their health itinerary, … |
BIEKE TACK; | 2021-02-01 |
| 34 | Comparative Study of Commercially Available Typhoid Point of Care Tests to Benchmark Current and Emerging Tools PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to perform a head to head comparison of 11 typhoid tests currently in the market and simultaneously develop a sample set that can be used in future evaluations of emerging technologies. The central objective is to evaluate different Typhoid Rapid Diagnostic Tests (RDTs) that are commercially available internationally for detecting antigens or antibodies to Salmonella Typhi and use Blood culture as standard for comparison. The end point will be to determine estimates of sensitivity and specificity for each test, with 95% confidence interval, using blood culture as reference. |
ROBERT ONSARE; | 2021-01-01 |
| 35 | Effect of Herbal Formulation on Karika Syrup on Thrombocytes Count PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Effect of Herbal Formulation Karika Syrup on Thrombocyte Count. |
HAFIZ MUHAMMAD ASIF; | 2021-01-01 |
| 36 | Clinical Trial to Compare The Efficacy and Safety of A Multiple Amino-acid Based ORS VS002A With The Standard WHO-ORS in The Management of Noncholera Acute Watery Diarrhea in Infants and Young Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background (brief): 1. Burden: Diarrhea is the second deadliest disease for under-five children globally and the situation is more serious in developing countries. It was responsible for 688 million illnesses and 499,000 deaths worldwide in children less than 5 years of age in 2015 (Kotloff, … |
INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH | 2020-12-01 |
| 37 | Evaluation of The Efficacy and Safety of Rifaximin in Combination With N-acetylcysteine (NAC) in Adult Patients With Irritable Bowel Syndrome With Diarrhea PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized, prospective proof of concept, double-blind, single site clinical trial to determine the efficacy of combined rifaximin and N-acetylcysteine (NAC) therapy vs. rifaximin alone in decreasing clinical symptoms in subjects with IBS-D. |
BIANCA CHANG; | 2020-11-13 |
| 38 | Comparative Study of Commercially Available Typhoid Point of Care Tests to Benchmark Current and Emerging Tools PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Typhoid fever (typhoid) is an enteric bacterial infection caused by Salmonella enterica serovar Typhi (Salmonella Typhi; S. Typhi). It is one of the most common bacterial causes of acute febrile illness in the developing world, with an estimated 10.9 million new cases worldwide and 116.8 thousand deaths in 2017. Like many febrile illnesses, typhoid presents with non-specific symptoms and signs, especially in its early stages. In routine healthcare settings in low- and middle-income countries (LMIC), typhoid fever is commonly suspected and treated empirically with antibiotics. This overuse of antibiotics creates a selective pressure for the development of antimicrobial resistance (AMR), … |
RUMINA HASAN; | 2020-10-25 |
| 39 | EFFICACY OF MORUS ALBA FRUIT EXTRACTS AND CHLORHEXIDINE ON SALIVARY STREPTOCOCCUS MUTANS AND PH LEVELS PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dental caries is highly prevalent across the globe including Pakistan and is associated with tooth loss, malocclusion and temporomandibular joint problems and sometimes may cause life threatening infections. Streptococcus mutans is considered to be one of the major pathogen responsible for the development of dental caries. As treatment of dental carries is quite expensive, main focus is on the prevention of dental carries. Chlorhexidine is the gold standard mouthwash used for the prevention of dental carries but its use has been associated with certain side effects including staining of teeth, … |
EID MUHAMMAD; | 2020-10-20 |
| 40 | Safe Food, Fair Food For Cambodia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Safe Food Fair Food for Cambodia (SFFF) is a Feed the Future Innovation Lab project funded by USAID. This 3-year project aims to improve food safety of animal source food (ASF) in Cambodia. SFFF was awarded to the International Livestock Research Institute (ILRI), National Animal Health and Production Research Institute (NAHPRI) and Livestock Development for Community Livelihood Organization (LDC) and in collaboration with Cambodian Ministry of Health CDC and NIPH. Based on the findings and consultations with food safety stakeholders in Cambodia, … |
DELIA RANDOLPH; | 2020-06-30 |
| 41 | Efficacy of Dietary Modulation With High Prebiotic and Probiotic Content on Nutritional and Metabolic Status in Schizophrenia Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The microbiota plays a vital role in the two-way communication between the gastrointestinal tract and the central nervous system (CNS), articulated as the microbiota-intestine-brain axis. This function provides sufficient evidence to establish a causal relationship between numerous neuropsychiatric disorders, such as schizophrenia. Besides, the microbiota modulation through the dietary pattern is related to the improvement of the physical and psychopathological health of patients. In this sense, the use of psychobiotics (prebiotics and probiotics with nutraceutical action) highlights. This research will be aimed to test the efficacy of prebiotic dietary modulation in patients diagnosed with schizophrenia, … |
ALFONSO SEVILLANO JIMÉNEZ; | 2020-06-25 |
| 42 | Retrospective Study From November 2019 -Febrauary 2020 on Severe Respiratory Illness to Access The Presence or Absence of COVID-19 in Patients Samples By Real-time PcR PF:4 Related Papers Related Patents Related Grants Related Experts View Abstract: A- Methodology adopted in the retrospective study: Sample Size Determination: 500 case presented from November 2019- February 2020 will be included in explore study from Ain shams … |
SARA HASSAN AGWA; | 2020-04-14 |
| 43 | Knowledge,Attitude and Practice of Food Handleres About Food Safety in Assiut University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The heavy burden of food borne diseases causes substantial economic losses to individual , households, health systems and entire nations. As poor food hygienic practices could contribute food -borne diseases in hospital, so food handlers’ knowledge, attitude and practicing is an important factor that is essential in order to lower food borne disease. All three traits; knowledge, attitude and education are compulsory to enable safe food handling practices |
AMARAT MOHAMED MAHMOUD; | 2020-04-01 |
| 44 | Arthritis in Assiut University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: – To define prevalence of different types of arthritis in patients attending Assiut University Children Hospital (AUCH) – To define prognosis of these different types – To evaluate management of arthritis in Assiut University Children Hospital, in comparison to international guidelines |
MOHAMED MASOUD ADB-ELMONEM; | 2020-04-01 |
| 45 | A Two-strain Probiotic (L Rhamnosus ATCC 53103 & L Reuteri DSM 29063) Compared With A Single Strain Probiotic (L Rhamnosus ATCC 53103) for Preventing Antibiotic-associated Diarrhea: An Open-label, Randomized, Noninferiority Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will use a noninferiority design to examine whether the administration of L rhamnosus ATCC 53103 &amp;amp;amp;amp;amp;amp;amp; L reuteri DSM 29063 (Flostrum Baby) is no worse than (or as good as) the administration of a recommended probiotic L rhamnosus ATCC 53103 (commercially available as Dicoflor, hereafter a reference product) for the prevention of antibiotic-associated diarrhea in children, |
HENRYK SZYMAŃSKI; | 2020-02-01 |
| 46 | Prebiotic GOS and Lactoferrin for Beneficial Gut Microbiota With Iron Supplements PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The ultimate goal of this research is to develop a means to safely administer iron supplements to infants in settings with a high infection burden. The investigators will conduct a randomized clinical trial in 6 month-old Kenyan infants in conjunction with mechanistic microbiota studies using a novel long-term continuous polyfermenter platform inoculated with immobilized fecal microbiota from Kenyan infants. Oral iron supplements are associated with a significant 15% increase in the rate of diarrhea in children in malaria-endemic areas. The most recent studies have shown that prebiotic galacto-oligosaccharides (GOS) can provide partial amelioration of the adverse effects of iron supplementation by enhancing the growth of barrier populations of bifidobacteria and lactobacilli. The investigators hypothesize that the combination of GOS with bovine lactoferrin, adding iron sequestration as well as antimicrobial and immunomodulatory activities, will provide almost complete protection against the adverse effects of added iron on the intestinal microbiota. |
GARY M BRITTENHAM; | 2020-01-15 |
| 47 | Phase 1 Randomized, Placebo-Controlled, Dose-Escalation Study of The Safety, Reactogenicity, and Immunogenicity of Trivalent (S. Enteritidis/S. Typhimurium/S. Typhi Vi) Conjugate Vaccine Against Invasive Salmonella Disease Administered Parenterally to Healthy U.S. Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, placebo-controlled dose-escalation study. The main purpose of this research is to test the safety and measure the immune response of the trivalent vaccine against invasive Salmonella disease. The vaccine will be tested over a range of doses. |
WILBUR CHEN; | 2019-10-28 |
| 48 | Clinical Effectiveness of Egg-derived Polyclonal Antibodies (IM-01) for The Treatment of Mild-moderate Clostridium Difficile Infection (CDI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients diagnosed to have mild-moderate CDI will be randomized to receive IM-01 egg-derived anti-C. difficile polyclonal antibodies in increasing dosages, twice daily, for a total of 10 – 14 days. Resolution of diarrhea and other symptoms and fecal test parameters will be used to assess clinical effectiveness of Immunotherapy with IM-01 antibodies. Patients will be followed for recurrence of CDI. Subjects who are assessed as non-respondents to IM-01 will be reassessed and treated with standard of care CDI antibiotics for 10 -14 days. |
THOMAS J LOUIE; | 2019-10-04 |
| 49 | Undetectable IgE As A Sentinel Biomarker for Humoral Immunodeficiency PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is trying to find out if an undetectable serum immunoglobulin E (IgE) is a biomarker, or early sign of, the development of immune deficiency. |
LARRY BORISH; | 2019-07-01 |
| 50 | Treatment of 21st Century Typhoid Fever in Children;Open Label Mono Vs Combination Drug Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates whether XDR Typhoid fever in children can be effectively treated with monotherapy (meropenum alone), or a combination (meropenum and azithromycin). |
FATIMA G SIDDIQI; | 2019-06-20 |
| 51 | Exploring The Bottleneck Hypothesis of The Pathogenesis of Bacteraemia in An Ambulatory Outpatient Human Experimental Infection of Salmonella Typhi PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Typhoid fever is an infection caused by the bacteria Salmonella Typhi (S. Typhi). S. Typhi causes disease principally in developing countries where communities do not have access to safe water or adequate sanitation. It is thought to cause illness in approximately 22 million people every year and up to 200,000 deaths, mostly in children. The bacteria are spread when faeces from infected individuals contaminate food and water sources. Symptoms of infection include headache, … |
ANDREW J POLLARD; | 2019-05-30 |
| 52 | Sonographic Assessment in Severe Ulcerative Colitis Patients Admitted for Intravenous Corticosteroids and Eligible for Infliximab Rescue Therapy; A Prospective Clinician-blinded Observational Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction Acute severe ulcerative colitis (ASUC) occurs in 15-25 % of all ulcerative colitis (UC) patients. Initial treatment with intravenous corticosteroids fails in 30-50 % of patients, for whom the next line of treatment is biological therapy or colectomy. Acute colectomy has a higher risk of morbidity and mortality than a scheduled colectomy. Data suggest that an accelerated administration of biological treatment in corticosteroid non-responders compared to clinical practice, 5-7 days with intravenous corticosteroids, may be superior in inducing disease remission, thus potentially avoiding acute colectomy. However, … |
JOHAN F. ILVEMARK; | 2019-02-21 |
| 53 | Point-of-Use Pathogen Identification Tool for Diarrhea PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Many people suffer from diarrhea every year. In the United States, it leads to about 130,000 hospitalizations and 3,000 deaths a year. Researchers want to test a tool that may show them what germs cause diarrhea. It is a simple paper strip test and doesn t require electric power. This may make it easier for health care workers to more quickly fight diarrheal diseases. Objective: To test a tool that may detect what germs cause diarrhea. Eligibility: People already enrolled in an active NIH protocol who have diarrhea Design: Participants will have 1 or 2 studies. They will give information about their symptoms, current medicines, and basic personal data. They will give a stool sample. Part of each sample will be tested in a lab. The rest will be stored indefinitely. No personal data will be connected to the samples. The stored samples may be used in future research. Positive test results will be reported to a participant s primary doctor |
WENDY A HENDERSON; | 2019-02-14 |
| 54 | Healthcare Resource Utilisation, Common Mental Health Problems, and Infections in People With Inflammatory Bowel Disease (IBD) PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Ulcerative colitis and Crohn’s disease are the commonest types of inflammatory bowel disease (IBD). Both conditions range in severity from no symptoms to being potentially fatal. Both conditions are treated with medications which suppress the immune system. It is not known whether this increases the risk for infections and cancers in these conditions. It is also recognised by healthcare professionals that these conditions cause a considerable amount of psychological distress. However, … |
MOMENTUM DATA | 2019-02-01 |
| 55 | Effects of Nutritional Fat on The Growth of Intestinal E. Coli PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Recent experiments in the lab of Prof. WD Hardt revealed, that in mice, 24 h exposure to a high-fat diet results in a breakdown of colonization resistance against Salmonella typhimurium. Mechanistic experiments identified bile acids as the mediator for reduced colonization resistance. Exposure to a high fat diet leads to increased bile acid secretion which in turn modify the intestinal microbiota. It is now the aim to verify the results of this study in human healthy volunteers. The nutritional habits of all participants will carefully be evaluated. In the intervention phase, … |
WOLF-DIETRICH HARDT; | 2019-01-24 |
| 56 | Pilot Clinical Study of DNA Vaccination Against Neuroblastoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is pilot open-label study to evaluate the safety and immunogenicity of a DNA vaccine strategy in relapsed neuroblastoma patients following chemotherapy and HSC transplantation. The combined form of the vaccine includes an intramuscular injection of the DNA-polyethylenimine conjugate and oral administration using the attenuated Salmonella enterica as DNA vaccine carriers. Objectives of the study: 1. To assess safety and document local and systemic toxicity to combined DNA vaccine 2. To determine immunogenicity of the vaccine 3. To evaluate clinical response to vaccination. Control of minimal residual disease in bone marrow and duration of remission. |
ALEXANDER MELESHKO; | 2019-01-09 |
| 57 | Fecal Microbiota Transplantation As A Therapeutic Strategy for Patients Infected With HIV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients eligible for the study will be selected on Fridays during the HIV consultation at the Infectious Diseases Department. Patients that meet the inclusion and exclusion criteria, will be randomized and assigned in two groups 1:1. A group will start intervention with FMT (fecal matter transplant) through frozen capsules and after seven days, … |
ADRIAN CAMACHO-ORTIZ; | 2018-09-06 |
| 58 | Comparison of Lactoferrin Vs Traditional Iron Therapy for Treatment of Iron Deficiency Anemia in School-age Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anemia is a great public health problem affecting both developing and developed countries. Iron deficiency anemia represents about 50% of causes of anemia worldwide. Lactoferrin fortified milk has a positive effect on Hb and iron status of infants. the hypothesis of this study is lactoferrin may have comparable efficacy to ferrous sulfate therapy with more tolerability and fewer side effects. the research question of this study is whether oral lactoferrin is effective for treatment of iron deficiency anemia, compared to traditional ferrous sulfate therapy regarding hemoglobin rise and side effects and tolerability. |
SAEED SALAH ABDULJALIL SOLIMAN; | 2018-09-05 |
| 59 | Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma After CPFA-rich Diet PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fatty acids containing a cyclopropane ring in their structure (CPFA) have been found in plants, fungi, a wide variety of bacteria and recently detected in dairy products and bovine meat. Little is known about CPFA in mammals, especially in human tissues. This work aims at investigating the presence of CPFA in plasma of humans after a regular consumption of CPFA from milk and cheese. A free living diet controlled in CPFA, mainly deriving from Grana Padano cheese and whole milk containing CPFA, will be consumed by 10 healthy normal weight volunteers for three weeks, … |
DANIELE DEL RIO; | 2018-08-06 |
| 60 | Investigation of Innate Immune Responses to Salmonella Typhi in Typhoid Fever in Children and Adults Patients and Vaccinees in Dhaka, Bangladesh PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Typhoid fever caused by Salmonella Typhi and Paratyphi causes over 21 million cases of febrile illness and 200,000 deaths are attributed to enteric fever each year. Typhoid fever is an enteric infection that results in febrile illness. Typhoid fever causes significant morbidity in the developing world especially young children.S. Typhi specific antibody responses are elicited in typhoid fever and following typhoid vaccination. Cross-reactive multifunctional CD+4 T cell mediated IL-17 responses have been shown in typhoid fever. As S. Typhi as an intracellular pathogen, … |
INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH | 2018-07-15 |
| 61 | Evaluation of A Typhoid Conjugate Vaccine Introduction Program in Navi Mumbai, India PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the impact of a government-led typhoid conjugate vaccine introduction program on typhoid disease burden in Navi Mumbai, India. |
STEPHEN P LUBY; | 2018-07-02 |
| 62 | Interaction Between Non-typhoid Salmonella, Host Microbiota, and Immune System During Acute Infection and Remission PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Stool and blood samples from patients with a non-typhoid Salmonella infection will be collected during an observation period of six months and analyzed for changes in the microbiota diversity and composition, mutation rates in the Salmonella strains and the specific immune response evoked by the infection. Findings are compared to healthy individuals and individuals with acute, infectious diarrhea caused by other microorganisms. |
BENJAMIN MISSELWITZ; | 2018-06-15 |
| 63 | Improvements Through The Use of A Rapid Multiplex PCR Enteric Pathogen Detection Kit in Children With Hematochezia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Children presenting for emergency department (ED) care with bloody diarrhea (i.e. hematochezia) represent a diagnostic challenge. Infectious enteric pathogens – Salmonella, Shigella and Shiga toxin-producing Escherichia coli (STEC) – … |
STEPHEN FREEDMAN; | 2018-06-05 |
| 64 | Fecal Microbiota Transplantation for The Treatment of Chronic Pouchitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with chronic pouchitis are treated with fecal transplant from several unrelated, healthy donors. The treatment consists of enemas of 100 mL fecal suspension, applied for 14 consecutive days. |
OLE THORLACIUS-USSING; | 2018-05-15 |
| 65 | Clinical Evaluation of The FilmArray® Global Fever (GF) Panel PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the clinical sensitivity and specificity of the FilmArray Global Fever (GF) Panel. |
BIOFIRE DEFENSE | 2018-03-26 |
| 66 | The Effect of A Multispecies Probiotic on Reducing The Incidence of Antibiotic-associated Diarrhoea in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this trial, the investigators aim to assess the effectiveness of a multispecies probiotic consisting of 2 strains of Bifidobacterium (B. bifidum W23, B. lactis W51) and 6 strains of Lactobacillus (L. acidophilus W37, L. acidophilus W55, L. paracasei W20, L. plantarum W62, L. rhamnosus W71, and L. salivarius W24) in reducing the risk of antibiotic-associated diarrhoea in a group of children undergoing antibiotic therapy for common infections. |
JAN ŁUKASIK; | 2018-02-16 |
| 67 | Cognitive, Emotional, and Neural Responses to Acute Inflammation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a pilot study to examine the effects of acute inflammation on cognition and emotion in healthy participants using a between-subjects, randomized, double-blind design. |
AOIFE S O’DONOVAN; | 2018-01-01 |
| 68 | Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies. What Does The Patient Suffer From When The Appendix Proves to Be Healthy? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Trial The aim of the study is to investigate which infectious diseases might mimic the symptoms of acute appendicitis to a degree to cause a diagnostic laparoscopy or laparoscopic appendectomy. The primary outcome is to compare the incidence of Yersinia spp. infection in patients, who undergo surgery due to suspected appendicitis, between those with and without appendicitis detected by polymerase chain reaction on rectal swabs. The secondary outcomes are comparison of the incidence of bacterial pathogens (Campylobacter spp., Salmonella spp., Shigella spp., Aeromonas spp.) and Enterobius vermicularis in the two groups. Rectal swabs, appendix swabs, … |
SIV FONNES; | 2017-11-21 |
| 69 | Saccharomyces Boulardii in The Prevention of Antibiotic-associated Diarrhea in Hospitalized Adult Patients With Lower Respiratory Tract Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Antibiotic-associated diarrhea (AAD) is the most common gastrointestinal complication of antibiotic use, with potentially serious clinical impact. The aim of this study is to assess the efficacy and safety of Saccharomyces boulardii in the prevention of AAD in adult patients with lower respiratory tract infection (LRTI) treated in a hospital. A multicenter, randomized, parallel-group, double-blind, placebo-controlled study is conducted whereby adults who are hospitalized due to LRTI and treated with intravenous antibiotics and randomized to capsules containing S. boulardii or indistinguishable placebo. The outcome measures were: relevant clinical features, gastrointestinal symptoms, and adverse events. |
BRANISLAVA MILENKOVIC; | 2017-11-01 |
| 70 | Investigation of The Prevalence of Sepsis in Adults in Multicenter Intensive Care Unıts in Turkey PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The pathophysiology and treatment of sepsis disease are still not fully known. International guides often refer to the studies done in the developed countries and suggest some treatments. The infrastructure of the developing countries is quite different. For this reason, it is not exactly scientific how much these proposals are reflected in patient treatment. In our study, We will try to reveal the treatment of sepsis. |
ILHAN BAHAR; | 2017-10-01 |
| 71 | Probiotic Modulation of Intestinal Microbiota in Long-term Intake of Proton Pump Inhibitors: Influence on Intestinal Inflammation and Digestion PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Long-term proton pump inhibitor use has been linked to intestinal dysbiosis, inflammation and gastrointestinal symptoms. Probiotics has been shown to correct dysbiosis, reduce inflammation and strengthen the gut barrier. The aim of this study is to evaluate the influence of a three months intervention with a probiotic on intestinal inflammation, bowel symptoms, dysbiosis and gut permeability. |
MEDICAL UNIVERSITY OF GRAZ | 2017-09-22 |
| 72 | Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic diarrhea is defined as stool volume of more than 10g/kg/day in toddlers/infants and greater than 200 g/day in older children that lasts for 14 days or more. Chronic diarrhea has many of causes can calcified as infectious & noninfectious causes. – Infectious causes as: – Escherichia coli, Giardia Lamblia, tuberculosis, Clostridium difficile & Shigella. – Noninfectious causes as(Abnormal digestive processes- Nutrient Mal -absorption- Immune/ inflammatory- Defects of electrolyte And metaboliteTransport- Motility disorders- Diarrhea associated With exogenous substances) There are four basic pathophysiological categories of diarrhea: as ( osmotic diarrhea- secretory diarrheas- motility related diarrhea- Inflammatory diarrhea) |
MOUSTAFA ABD ELLATIF; | 2017-08-22 |
| 73 | Iron and Infection: Neonatal Nutritional Immunity (NeoInnate Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The motivation for this study was produced from our preliminary data, which showed that during the first 96 hours of life a full-term neonate will actively reduce the overall serum iron concentration of their blood and the transferrin saturation decreases rapidly from 45% in cord blood to ~20% by six hours post-delivery. The Investigators hypothesise that this active sequestration of iron, which results in hypoferremia, is done in an effort to limit susceptibility to infection, a process referred to as nutritional immunity. Currently, … |
CARLA CERAMI; | 2017-07-25 |
| 74 | The Non-specific Effects of Vaccination Related to Mortality and Morbidity in Nanoro Health and Demographic Surveillance System Cohort PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: It has long been recognized that the positive effects of vaccination on childhood mortality cannot be solely attributed to a decline in the disease targeted by the vaccine. These so-called non-specific effects of vaccination have so far mostly been linked to mortality. However, it has been suggested that non-specific effects may also effect morbidity and nutritional status. This study aims to further explore the correlation between vaccination, susceptibility to infectious diseases (particularly malaria and bacterial infections), … |
ANDRÉ VAN DER VEN; | 2017-06-17 |
| 75 | EURECA (EUropeanRElapseCAlprotectin) Study – Calprotectin As Prediction Marker of Relapse in Patients With Quiescent Ulcerative Colitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the correlation of fecal calprotectin (FC) values to quiescent ulcerative colitis and to disease activity (relapse) as assessed by clinical data and endoscopy. |
DIASORIN | 2017-06-02 |
| 76 | ESBL-producing Enterobacteriaceae in Patients With Traveller’s Diarrhoea- A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with traveller’s diarrhoea frequently harbour Extended Spectrum Betalactamase (ESBL)-producing Enterobacteriaceae (EPE) returning from EPE-endemic areas. This study investigates to what extent travellers returning to Sweden with traveller’s diarrhoea carry ESBL in their stool. The isolates are examined further according to species, phenotype, antibiogram and whole genome sequencing. |
OSKAR LJUNGQUIST; | 2017-02-01 |
| 77 | Efficacy of Fermented Rice Flour for The Treatment of Atopic Dermatitis : Randomized, Double-Blind, Placebo-Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Study Evaluate the efficacy of the subministration of fermented rice flour (7 g/day) on the clinical course of patients with moderate or severe Atopic Dermatitis, in terms of a reduction in the SCORAD score, during the study period and four weeks after the suspension of the treatment. |
ENZACARMINA D’AURIA; | 2017-01-23 |
| 78 | The Potential Role of The Household Environment As The Reservoir for Invasive Salmonellosis in Children, Kisangani, DR Congo PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bloodstream infections caused by non-typhoid Salmonella (NTS) are a major killing disease in Sub-Saharan Africa. Despite the high case fatality rate, the main reservoir -human, zoonotic or environmental- for invasive NTS rests unknown. The main objective of this study is to assess 1. the household environment (household member, cattle and pets, rats) for intestinal carriage of NTS and 2. the household water supply for presence of NTS . Households of children with proven NTS invasive infection will be addressed. |
DADI FALAY; | 2017-01-01 |
| 79 | Lactobacillus Reuteri DSM 17938 in The Prevention of Antibiotic-associated Diarrhea in Children: Protocol of A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess the effect of Lactobacillus reuteri DSM 17938 administration for the prevention of diarrhea and AAD in children. |
HANNA SZAJEWSKA; | 2016-12-01 |
| 80 | Colitis Prospective Cohort Study: Determining The Aetiologies of Acute Colitis and Developing A Diagnostic Score to Identify Patients Requiring Specific Investigations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aetiologies of computed tomography-diagnosed acute colitis remain surprisingly unknown. Moreover, no diagnostic tool or clinical score allow to quickly determine or at least stratify the exact cause of colitis in patients admitted at an Emergency Ward and to direct them to the appropriate therapeutic care. The aims of the present study are to describe the presentation and aetiologies of acute colitis, and to develop diagnostic methods to guide patients admitted for acute colitis to the appropriate therapeutic care, notably colonoscopy. |
JEREMY MEYER; | 2016-11-01 |
| 81 | A Phase 2a, Observer Blind, Randomized, Controlled, Single Center Study To Evaluate The Safety, Reactogenicity And Immunogenicity Of 2 Doses Of The GVGH 1790GAHB Vaccine Against Shigella Sonnei, Administered Intramuscularly In Adult Subjects From A Country Endemic For Shigellosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and the immunogenicity of two different doses of the GVGH S. sonnei vaccine in healthy adults and represents the first step towards testing of the GMMA vaccine in the vaccine target population of children from developing countries where shigellosis is endemic. |
GLAXOSMITHKLINE | 2016-08-08 |
| 82 | International Multicenter, Double-blind, Randomized, Parallel Group Placebo-Controlled Clinical Trial of Efficacy and Safety of Ergoferon in The Treatment of Viral Intestinal Infections in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to obtain additional data on efficacy and safety of Ergoferon in the treatment of viral intestinal infections in inpatient children. |
MATERIA MEDICA HOLDING | 2016-06-23 |
| 83 | Phase 2b, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate The Efficacy and Immunogenicity of The Intramuscular Norovirus GI.1/GII.4 Bivalent Virus-like Particle Vaccine in Healthy Adults Aged 18 – 49 Years PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of the Norovirus (NoV) GI.1/GII.4 bivalent virus-like particle vaccine against moderate or severe acute gastroenteritis (AGE) due to genotype-specific (GI.1 and GII.4) NoV strains. |
TAKEDA | 2016-06-14 |
| 84 | Parallel Group, Double Blinded, 1:1, Randomized Controlled Phase III Trial of Co-trimoxazole Versus Azithromycin for The Treatment of Undifferentiated Fever In Nepal PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine whether azithromycin or cotrimoxazole is the best empirical treatment for undifferentiated febrile illness in Nepal |
BUDDHA BASNYAT; | 2016-05-23 |
| 85 | The Effects of Zinc Supplementation in Children With Sickle Cell Disease in Western Kenya: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Zinc is a nutritionally essential trace element found in previous studies to reduce growth retardation and improve immune function, which may also result in decreased incidence of infectious diseases including malaria, pneumonia and diarrhea. Sickle Cell Disease (SCD) patients are known to be susceptible to zinc deficiency and appear to benefit from zinc supplementation. The proposed pilot research project aims to investigate the influence of zinc supplementation on incidence of malaria infections, … |
LUCAS OTIENO TINA; | 2016-05-20 |
| 86 | Comparison of Fecal Microbiota Between Patients With Early and Late Crohn’s Disease and Relationship With Different Genetic and Serological Profiles PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The cause of CD could be different according to age at onset of CD symptoms. Indeed we know that some very young patients at CD diagnosis have particular genetic variants as abnormalities of the IL10R that are regarded as quite monogenic disease. In the other way, the microbiota also undergoes substantial changes at the extremes of life, … |
CORINNE GOWER-ROUSSEAU; | 2016-05-09 |
| 87 | A Double Blind, Placebo Controlled, Randomised, Single Centred, Parallel Study to Determine The Potential of B-GOS, to Beneficially Influence The Wellbeing and Ageing in Healthy 52-65 Years Old Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate the potential of B-GOS to beneficially influence the wellbeing and ageing in healthy adults (52-65 years old). The study will consist of a 4 month randomised double blind parallel treatment period with either B-GOS of Placebo, and 1 month follow up period without treatments. |
CLASADO | 2016-03-01 |
| 88 | Markers of T Cell Suppression: Antimalarial Treatment and Vaccine Responses in Healthy Malian Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: People with malaria often show altered immune responses to many illnesses and vaccines. This means that the malaria might cause immune suppression. It is not clear how or which vaccines are impacted by malaria. It is also not clear if the impacts are such that people should be preemptively treated before they get vaccinations. Researchers want to see if there is a link between taking an antimalaria drug prior to getting vaccines and the immune response to those vaccines. To do this, … |
SARA A HEALY; | 2015-09-04 |
| 89 | A Phase IIb, Observer-blind, Randomised Controlled Trial to Assess The Immunogenicity and Protective Efficacy of Vi Conjugated (Vi-TCV) and Unconjugated (Vi-PS) Polysaccharide Vaccines in Preventing Typhoid Infection Compared to A Control Vaccine (Meningococcal ACWY), Using A Human Challenge Model of Typhoid Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Using an established model of human typhoid infection, whereby healthy adults are deliberately exposed to typhoid-causing bacteria, the investigators will determine how effective a new typhoid conjugate vaccine (Vi-TCV) is in preventing infection. The new typhoid vaccine will be compared with a control vaccine (meningococcal ACWY). The protective effect of a currently used typhoid polysaccharide vaccine (Vi-PS) will also be studied and compared with the control vaccine using this model of typhoid infection. A second component of this study will involve vaccinating 15-20 participants with Vi-PS. Serum will be obtained prior to vaccination and 4-6 weeks after vaccination. The post-vaccination serum will be pooled and used to create an anti-Vi IgG serum standard. |
ANDREW J POLLARD; | 2015-09-01 |
| 90 | A Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Microbial Translocation and Chronic Immune Activation in HIV-infected Malian Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The composition of the intestinal bacterial flora effects gut immunologic function and intestinal barrier integrity. HIV infection impairs gut immune and epithelial function resulting in an altered gut bacterial flora and leakage of gut bacterial products into the bloodstream. These bacterial products can overstimulate the immune system leading to increased inflammation and HIV disease progression. The investigators will investigate whether oral supplementation of certain beneficial probiotic bacteria may attenuate these processes in HIV infected women in Mali, Africa. This is a single arm study to evaluate the effect of 12 weeks of combination oral probiotic supplementation (VSL#3, Sigma-Tau Pharmaceuticals – … |
DANIEL E NIXON; | 2015-05-01 |
| 91 | Randomised Placebo Controlled Trial of Faecal Microbiota Transplantation in Irritable Bowel Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of thus study is to determine if faecal microbiota transplantation will result in improvement in clinical outcomes in patients with irritable bowel syndrome. |
FERGUS SHANAHAN; | 2015-03-01 |
| 92 | A Controlled Before and After Study to Measure The Effect of An Urban Sanitation Intervention on Child Health, in Low-income Neighborhoods of Maputo, Mozambique PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the health impact of a basic sanitation intervention in Maputo, Mozambique. |
JOE BROWN; | 2015-02-01 |
| 93 | Investigating The Effects of Typhoid Vaccine on Sleep in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Research studies have found a relationship between the immune system (how the body reacts to an infection) and the development of depression. As it is still unclear how they might be linked the investigators will use a typhoid vaccination to activate the body’s immune system and will measure the response by looking at changes in sleep patterns. |
ANN L SHARPLEY; | 2015-02-01 |
| 94 | 64N Nutraceutical for The Prevention of Childhood Diarrhea and Pneumonia in Low Resource Settings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the occurrence of childhood diarrheal disease and pneumonia in subjects under the age of 5 years in low resource settings who have received prophylactic 64N nutraceutical (64N)as a neonate as compared with neonates who have not received prophylactic 64N. |
DONNA M ROHRS; | 2015-01-01 |
| 95 | Investigating The Mechanisms and Determinants of Systemic and Mucosal Immunity to Salmonella Typhi and Salmonella Paratyphi A in Naïve and Previously Exposed Individuals – A Challenge and Rechallenge Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Enteric fever, an infection characterised by diarrhoea and rash, is most often caused by a bacteria called Salmonella enterica. After ingesting contaminated food or drink, the Salmonellae travel first to the gut, then the bloodstream, from where they can infect other parts of the body. Antibiotics are used to kill the bacteria, but with increasing rates of antibiotic resistance, this treatment is becoming less effective. Two Salmonella variants, Typhi and Paratyphi, cause over 30 million cases of enteric fever and more than 200,000 deaths per year, mostly in developing countries. While improved hygiene and sanitation should eventually eliminate enteric fever, … |
ANDREW POLLARD; | 2014-12-01 |
| 96 | Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Single Center, Randomized, Controlled Pilot Study in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Oxygen treatment is widely used in acutely ill patients. In particular, oxygen treatment is routinely used in acute coronary syndrome (ACS) patients with suspected acute myocardial infarction and variably recommended in ACS-guidelines, despite very limited data supporting a beneficial effect. Immediate re-opening of the acutely occluded infarct-related bloodvessel via primary percutaneous coronary intervention (PCI) is the treatment of choice to limit ischemic injury in the setting of ST-elevation ACS (STE-ACS). However, the sudden re-initiation of blood flow achieved with primary PCI can give rise to further damage, … |
LEIF SVENSSON; | 2014-10-01 |
| 97 | IDIS Project Work Package 2: Establishing A Biobank at ITM and Collaborating Centres PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The IDIS study aims to develop a new rapid diagnostic test for invasive salmonellosis using samples (blood, urine) collected from patients with fever and healthy controls at the Institute of Tropical Medicine (ITM) and collaborating centers. The samples are collected after informed consent and/or assent is given by the participant and are stored in a -80 ⁰C freezer after processing (centrifugation and/or aliquoting). Basic information regarding the patient and the samples are coded and stored in a protected Microsoft Access database. The samples will be shipped to Belgium for proteomic analysis. Identification of Salmonella specific proteins in the samples will hopefully support the development of a rapid diagnostic test. Once this test has been developed, the samples will also be used for validation and evaluation of this test. |
LAURA KUIJPERS; | 2014-09-01 |
| 98 | Reduction of C-Difficile Infection Using Fecal Microbiota Transplant PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Clostridium-difficile (C-difficile) is a gram positive anaerobic spore-forming bacterium that can lead to severe diarrhea and pseudomembranous colitis. According to Schroeder (2005), there are approximately 3 million cases annually with a mortality rate of 1-2.5 %. It is most often associated with overuse of antibiotics. According to Bartlett & Gerding (2008), 15-25% of anti-microbial-associated diarrhea is caused by C-difficile. The purpose of this study is to determine if donor fecal microbiota transplant via colonoscopy reduces refractory C-difficile infection better than current routine methods such as continued antibiotic treatment. Specifically, … |
SHERRI MENDELSON; | 2014-04-01 |
| 99 | Efficacy and Safety of Fecal Microbiota Transplantation for Severe Clostridium Difficile Associated Colitis Related Papers Related Patents Related Grants Related Experts View Highlight: Clostridium difficile has become one of the leading causes of hospital acquired infections, and is associated with increased mortality. Patients with C. difficile associated disease (CDAD) possess deficiencies in ‘normal’ fecal microbial composition, most likely as a result of earlier antibiotic usage. The current standard of care treatment for severe C. difficile, which consists of antibiotics, does not restore the microbiota. Restoration of the normal colonic microbiota by fecal microbiota transplantation (FMT) may enable reversion colonic microbial population to a more ‘normal’state and lead to cure. A few patients develop severe CDAD which may be complicated by adynamic ileus, … |
STRAHILEVITZ JACOB; | 2014-04-01 |
| 100 | Development of A Human Model of Salmonella Enterica Serovar Paratyphi A Challenge in Healthy Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Enteric fever is responsible for over 20 million illnesses and 200,000 deaths each year. S. Paratyphi A accounts for a substantial and increasing proportion of these cases, as high as 90% in some regions of Asia. There are currently no vaccines directed against S. Paratyphi A, although there some candidates in preclinical and phase 1 trials. This study is funded by the European Vaccine Initiative and the Bill and Melinda Gates Foundation. Paratyphoid is a human-restricted infection, for which there are currently no small animal models available. In order to further our understanding of the host-pathogen interactions, … |
ANDREW POLLARD; | 2014-03-01 |
| 101 | Evidence of Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn’s Disease: Family Studies and Relations With A Particular Genetic Profile and Serological. Comparison of Affected Individuals, Their Siblings and Healthy Controls PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Transversal multicentric French study on the microbiota in patients with Crohn’s disease and their first degree healthy relatives The primary objective is the comparison of microbiota between patients with CD, healthy controls non genetically linked and first degree healthy relatives of patients with CD. |
CORINNE GOWER-ROUSSEAU; | 2013-10-03 |
| 102 | Cross-reactive Immunity Elicited By Oral and Parenteral Typhoid Vaccines Against Non-typhoid Salmonellae PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In a recent controlled study, the investigators explored cross-reactive immune responses against different Salmonella spp. in healthy volunteers immunized with either the oral (Vivotif® ) or parenteral (Typherix®) typhoid vaccines (ISRCTN68125331). In the present study immune responses will be studied in a group receiving both of these vaccines and in the previously immunized volunteers after booster immunization (same groups receive same vaccines 2-4 years after primary immunization). |
ANU KANTELE; | 2013-10-01 |
| 103 | Use of Traditional Chinese Medicine (Ren Shen Yang Rong Tang) Against Microinflammation in Hemodialysis Patients: A Quasi-randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Participants and study design: Subjects were recruited and selected for uremic patients on maintenance hemodialysis (HD) who informed us of their interest in the investigators study and were mentally capable to give an informed written consent and willing to comply with study requirements. The inclusion criteria were 18 years or older, with at least 3 months maintenance HD. The exclusion criteria were malignancy, acute infection, gastrointestinal bleeding, pregnancy, … |
PO-JEN HSIAO; | 2013-01-01 |
| 104 | Global Genomic and Proteomic Profiling of African Children With Typhoid Fever PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To develop a rapid, sensitive, and inexpensive diagnostic method, as well as more efficacious vaccine, for countries where typhoid fever remains a major public health burden. |
STEPHEN OBARO; | 2012-09-01 |
| 105 | Role of BCG Vaccination As Booster on Salmonella Typhi Vaccine PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The BCG (bacillus Calmette-Guerin) vaccine is used for the protection against tuberculosis. Apart from it’s protective effect against tuberculosis BCG vaccine has been shown to have non-specific effects on the innate immune system and is in epidemiological studies associated with reduced mortality due to infectious diseases. Several studies have shown that BCG can boost the effect of other vaccines. The present study aims to investigate the boosting effect of BCG on the response to typhoid fever vaccine (TFV) and to assess the non-specific effects of BCG on the innate immune system at early timepoints by vaccinating volunteers with either TFV alone or BCG followed by TFV 14 days later. The study hypothesis is that when BCG is given 14 days before typhoid fever vaccine a better vaccination result in terms of antibody production will be accomplished against typhoid fever due to the effects of BCG on the innate immune system. |
MIHAI NETEA; | 2012-07-01 |
| 106 | Effects of Acute Systemic Inflammation on Arterial Stiffness and Microcirculation Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the effect of acute inflammation on arterial stiffness and microcirculation. Patients with severe sepsis will be compared with age-, sex- and cardiovascular risk factors-matched controls. The primary outcome is the carotid-femoral pulse wave velocity. The other outcome measures are: systemic hemodynamics (systolic, diastolic, mean and pulse blood pressures, heart rate, cardiac output, left ventricular ejection fraction, systemic vascular resistances), central hemodynamics (aortic systolic, diastolic, mean and pulse pressures, and augmentation index), thenar tissue oxygen saturation, biological makers of inflammation (plasma fibrinogen, C-reactive protein, interleukin-6, matrix metalloproteinases -2, -9, tissue inhibitor of metalloproteinase 1), … |
BRUNO LAVIOLLE; | 2012-02-23 |
| 107 | A Randomized, Blinded, Placebo-Controlled Phase 1 Study to Evaluate The Safety and Immunogenicity of GLA in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The advent of vaccines contributed to major improvements in human morbidity and mortality due to infectious diseases such as polio, small pox, measles and diphtheria. However infectious diseases like HIV, malaria and tuberculosis continue to be major causes of death worldwide and conventional vaccine strategies have not been successful. The fundamental problem is that current protein based vaccines do not elicit the necessary T-cell immunity. Experimentally, adjuvants can be given in conjunction with a vaccine to activate and mature the dendritic cell (DC), … |
MARINA CASKEY; | 2011-07-01 |
| 108 | Oral Probiotics Lactobacillus Rhamnosus GR-1 and Lactobacillus Reuteri RC-14 Reduce Group B Streptococci Colonization in Pregnant Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine whether daily use of oral gelatin capsules containing dried viable Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 can reduce the GBS colonization rate of vagina and rectum in pregnant women who present with GBS-positive diagnosed by GBS culture at 35-37 weeks gestation. This study is a prospective double blind randomized clinical trial. Vaginal and rectal GBS screening culture are carried out for all pregnant women at 35-37 weeks of gestation in our out-patient department. Subjects with vagina and rectum GBS colonization are invited to participate in our study after informed consent. A total of 200 pregnant women will participate in the study during the 12-months trial period. They are randomly assigned to one of the two groups. The study group is treated with two oral capsules of probiotics once daily (before sleeping) for 14 days, and the control group will take 2 capsules of placebos. Vaginal and rectal GBS culture is repeated for all participators 2 weeks later. All participators will treated according to GBS guideline by CDC in 2002 during laboring. |
CHINA MEDICAL UNIVERSITY HOSPITAL | 2011-04-01 |
| 109 | Positron Emission Tomography of Infection and Vasculitis (PETU) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications. |
ANNE ROIVAINEN; | 2011-01-01 |
| 110 | A Prospective Single Arm, Open-label, International, Multicenter Study to Evaluate The Safety, Efficacy and Pharmacokinetics of Atazanavir (ATV) Powder Boosted With Ritonavir (RTV) With An Optimized NRTI Background Therapy, in HIV Infected Pediatric Patients Greater Than or Equal to 3 Months to Less Than 6 Years. (Pediatric Atazanavir International Clinical Evaluation: The PRINCE I Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether atazanavir powder combined with ritonavir is safe and well tolerated and produces appropriate drug exposure in children ≥3 months to <6 years of age. |
BRISTOL MYERS SQUIBB | 2010-10-13 |
| 111 | The Role of Short-course Ceftriaxone Therapy in The Treatment of Severe Nontyphoidal Salmonella Enterocolitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the investigators study is to evaluate if short-course of ceftriaxone therapy could shorten the clinical courses of severe nontyphoidal Salmonella enterocolitis in children and the excretion of Salmonella in feces. |
MING_HAN TSAI; | 2010-08-01 |
| 112 | Phase I Trial of A Live Oral Salmonella Enterica Serovar Paratyphi A Vaccine Harboring Mutations in GuaBA and ClpX PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether CVD 1902 (a live, attenuated, oral vaccine) is safe and effective in the prevention of Salmonella enterica serovar paratyphi A infection. |
KAREN KOTLOFF; | 2010-05-01 |
| 113 | A Phase 1 Study of An IL-2 Expressing, Attenuated Salmonella Typhimurium in Patients With Unresectable Hepatic Spread From Any Non-Hematologic Primary PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The working hypothesis is that oral administration of an attenuated strain of Salmonella typhimurium is safe and efficacious for patients with unresectable hepatic metastasis from a solid tumor cancer. The primary objective of the study is to determine the MTD of Salmonella typhimurium in the treatment. |
EDWARD W. GREENO; | 2010-04-01 |
| 114 | Transdermal Absorption of DMPS and Its Effect on Urinary Mercury Excretion Related Papers Related Patents Related Grants Related Experts View Highlight: DMPS is a metal chelator which is approved for use in Europe. While not an FDA-approved drug in the US, it is easily obtained and administered by alternative health practitioners to their patients. A formulation called ‘TD DMPS’ (transdermal DMPS) is in use, … |
ANNE-MICHELLE RUHA; | 2010-04-01 |
| 115 | Confocal Laser Endomicroscopy in Patients With Diarrhea PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to determine the frequency of different gastrointestinal disorders as the cause of diarrhea in patients at a tertiary referral center using confocal laser endomicroscopy. |
MARKUS F. NEURATH; | 2010-02-01 |
| 116 | Mycobacterial and Opportunistic Infections in HIV-Negative Patients Associated With Autoantibodies to Interferon-gamma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Opportunistic infections are caused by bacteria, mycobacteria, fungi or viruses that do not normally cause infections in people with healthy immune systems. Some of these infections can cause public health concerns, especially in areas with limited access to treatment. People who acquire opportunistic infections usually have diseases that affect their immune systems, such as human immunodeficiency virus (HIV), or do not have enough white blood cells to fight the infection. However, … |
CHRISTA S ZERBE; | 2010-01-07 |
| 117 | Bovine Colostrum for Patients With Non Alcoholic Fatty Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Trial Synopsis: Bovine Colostrum for patients with non alcoholic fatty liver disease (NAFLD). Design: This is a single-arm, open-label, before-and after exploratory trial of 30 days of Bovine Colostrum Powder (BCP) to improve NAFLD and the metabolic syndrome. Duration: 8 weeks per subject. Sample Size: 30 subjects. Population: Patients with biopsy proven NASH (NAS of > 4) and an ALT level of ≥ 30 (U/L). Regimen Study treatment will consist of BCP, three 1.2 g oral tablets (equivalent to 600 mg of BCP each) for 4 weeks, … |
HADASSAH MEDICAL ORGANIZATION | 2010-01-01 |
| 118 | Comparative Phase I Safety and Immunogenicity in Adult Volunteers of Three Recombinant Attenuated Salmonella Typhi Vaccine Vectors Producing Streptococcus Pneumoniae Surface Protein Antigen PspA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this Phase I clinical study, three recombinant, avirulent Salmonella Typhi (RASV) strains each expressing the Streptococcus pneumoniae surface protein, PspA, will be compared as live biological vaccine vectors to evaluate safe and tolerable, single, oral dose levels in adult subjects. |
SHARON FREY; | 2009-08-01 |
| 119 | Phase 3 Study of Lactobacillus Reuterii in Patients With Symptomatic Non-complicated Diverticular Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the effectiveness and the tolerability of the Lactobacillus reuteri in the control of the diverticular disease symptoms and in the prevention of acute diverticulitis episodes. |
VITO ANNESE; | 2009-02-01 |
| 120 | The Treatment Effect of Bio-Three on Children With Enteritis Due to Salmonella or Rotavirus or Any Unknown Reason PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diarrhea due to acute enteritis is a common symptom in the children. Lots of patients are infected by rotavirus or salmonella. Base on the past researches, there is benefit effect of probiotics on patients with diarrhea or acute enteritis. In this clinical study, bio-Three, a probiotic which contains three independent probiotics, will be used in patients with acute diarrhea. This is a single site, … |
YUNG-FENG HUANG; | 2009-02-01 |
| 121 | A Controlled Study of Salmonella Ty21a and Cholera/ ETEC-vaccine and The Role of Oats in Daily Diet As A New Treatment in Patients With Mild or Moderate Ulcerative Colitis Related Papers Related Patents Related Grants Related Experts View Highlight: Ulcerative colitis is a chronic inflammatory bowel disease caused by an imbalance between natural defence mechanisms in the intestinal mucosa and microbes in the intestinal lumen. We hypothesise that an improvement or even normalisation of this balance may be achieved by the use of vaccines and dietary oats. The combined use of oral typhoid vaccine and cholera/ETEC-vaccine is supposed to stimulate mucosal defence factors, while dietary oats modifies the microbial environment inside the intestinal lumen. Or study aim is to show if such treatment brings symptom relief to patients with ulcerative colitis. |
GUNNAR NYSÆTER; | 2008-10-01 |
| 122 | Community Acquired Bacteremic Syndromes in Young Nigerian Children PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: To define the etiologic agents of community acquired bacteremic syndromes (defined as septicemia, bacteremia, pneumonia and/or meningitis) in a malaria endemic setting. |
STEPHEN OBARO; | 2008-09-01 |
| 123 | Introduction of An Oral Live Human Rotavirus (Rotarix) Vaccine in Matlab PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be conducted in the Matlab Health and Demographic Surveillance System (HDSS) field area of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) to determine the population effectiveness of Rotarix in Bangladeshi children. Villages in both intervention and government comparison areas will be included in this evaluation. We propose to introduce Rotarix into half of the villages of the Matlab HDSS. In villages randomized to receive the vaccine, all eligible children will be offered Rotarix during their first two Expanded Programme on Immunization (EPI) visits, … |
K ZAMAN; | 2008-09-01 |
| 124 | The Effect of Jarro-Dophilus EPS Probiotics on The Prevention of Diarrhea, Quality of Life and Symptoms in Adults Receiving Antibiotic Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate if ingestion of a probiotic formula (Jarrow-Dophilus EPS)reduces incidence of diarrhea and improves the quality of life of patients receiving antibiotic therapy. |
YVONNE M SHEVCHUK; | 2008-03-01 |
| 125 | Strain and Dose-Finding Study of DS26-1 and WS0115A Enterotoxigenic E. Coli (ETEC) Challenge Strains That Express CS19 Fimbriae PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This will be a strain and dose-finding study in which CS19-ETEC strain WS0115A will be administered at a starting inoculum of 5 x 108 colony forming units (cfu) to 5 subjects as the initial step to establish a human disease model. If an 80% attack rate (AR) for predefined diarrheal disease is achieved without high output diarrhea, the same inoculum will be given to 5 – 10 more subjects for confirmation of AR. If an 80% AR is not achieved, … |
AUGUST LOUIS BOURGEOIS; | 2007-09-01 |
| 126 | A Multicenter, Double-blind, Randomized, Escalating Dose-ranging Study to Investigate The Safety and Immunogenicity of The VAX102 Influenza Vaccine in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the safety and immunogenicity of VAX102 [Flagellin.HuM2e], a recombinant, inactivated, subunit influenza vaccine given as a two dose regimen at a range of doses. |
CHRISTINE TURLEY; | 2007-09-01 |
| 127 | Open-Label Trial of A Prebiotic Preparation Containing Inulin and Oligofructose (Synergy-1) for The Treatment of Mild to Moderate Acute Ulcerative Colitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Based on the efficacy of inulin and oligofructose in treating experimental colitis and emerging evidence suggesting probiotics are efficacious in maintaining and inducing remission in human ulcerative colitis (UC), the investigators intend to conduct an open label study using Synergy-1, a 1:1 oligosaccharide/ inulin mixture, in patients with mild to moderately active left-sided UC. The investigators hypothesize that oligofructose-enriched inulin (Synergy-1) can be used safely in the treatment of mild to moderate UC, … |
LEVINUS DIELEMAN; | 2007-08-01 |
| 128 | A Randomized, Double Blind, Controlled Study to Determine The Efficacy of Zinc Supplementation on Diarrhea Incidence in An Adult Population in Western Kenya PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Zinc deficiency is prevalent in children in developing countries. Zinc-supplementation is proven to reduce the duration and severity of childhood diarrhea in randomized controlled trials. However, despite this evidence, its efficacy to reduce diarrhea morbidity in adults remains unknown. The main objective of this study is to determine the efficacy of Zn-supplementation on diarrhea incidences in a vulnerable adult population. The study will be carried out in Kombewa division, … |
MARIA E BOVILL; | 2007-07-01 |
| 129 | Exploratory Study to Evaluate The Effect of L-isoleucine Supplemented Oral Rehydration Solution in The Treatment of Acute Diarrhoea in Children and in Inducing Innate Immunity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Efforts are continuing to improve the efficacy of oral rehydration solution in terms of reducing the severity (stool volume) and duration of diarrhoea (enhancement of recovery). Antimicrobial peptides, produced by the epithelial cells, represent an important component of the innate immunity of all epithelial surfaces of the body including intestine. Induction of expression of antimicrobial peptides on epithelial cell surface, may thus hasten recovery from infectious diarrhoea. Isoleucine is an essential amino acid that is easily available and not very expensive, … |
INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH | 2007-07-01 |
| 130 | Ulcerative Colitis European Registry: A Prospective, Observational, Non-interventional, Post-Marketing Safety Surveillance Program PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, safety surveillance registry in participants with moderate-to-severe active ulcerative colitis (UC). |
MERCK SHARP & DOHME | 2007-06-01 |
| 131 | Efficacy and Safety/Tolerability of Ragweed MATA MPL, A Randomized, Placebo-Controlled, Double-Blind Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Ragweed MATAMPL has been developed by Allergy Therapeutics to provide pre-seasonal specific immunotherapy for patients with proven type I hypersensitivity to cross reacting ragweed pollens causing rhinitis and/or conjunctivitis with or without mild to moderate asthma bronchiale. The purpose of this study is to compare the efficacy of Ragweed MATAMPL versus placebo in ragweed-allergic subjects following 4 subcutaneous injections of study medication administered before the start of the 2007 ragweed pollen season |
ALLERGY THERAPEUTICS | 2007-03-01 |
| 132 | Efficacy and Safety/Tolerability of Grass MATA MPL, A Randomized, Placebo-Controlled, Double-Blind Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Grass MATA MPL has been developed by Allergy Therapeutics (UK) Ltd. to provide pre-seasonal specific immunotherapy for patients with proven type I hypersensitivity to cross reacting grass pollens causing rhinitis and/or conjunctivitis with or without mild to moderate asthma bronchiale. The purpose of this study is to compare the efficacy of Grass MATA MPL versus placebo in grass-allergic subjects following 4 subcutaneous injections of study medication administered before the start of the 2007 grass pollen season. |
ALLERGY THERAPEUTICS | 2006-11-01 |
| 133 | Long Term Protection By and Persistence of Vi Antibodies Induced By Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age Related Papers Related Patents Related Grants Related Experts View Highlight: Typhoid fever remains an important cause of morbidity and mortality in the developing world. It is estimated that more than 16 million cases and about 600,000 deaths occur annually, most of which occur in Southeast Asia and Africa. Ingestion of food or water contaminated by acutely infected persons or chronic carriers is the most common form of transmission. As a result, typhoid fever is prevalent where unsafe drinking water or contaminated food is common. Typhoid fever is highly endemic in Vietnam, … |
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT NICHD | 2006-10-05 |
| 134 | NCCLS Interpretive Criteria for Salmonella PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the clinical significance of gene mutations encoding antibiotic resistance, but not expressed as clinical resistance, in Salmonella bacteria |
DAVID PATERSON; | 2006-03-01 |
| 135 | Postmarketing Study of Probiotics Medication in Childhood Diarrhea PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Probiotic bacteria inhabit the gastrointestinal tracts of healthy individuals and may improve the health status of patients with digestive disease. The first aim of our study will seek to determine if probiotics medication (Bio-Three) inhibit gastrointestinal infection and reduce its inflammatory response in the intestine. The second aim will explore the bacterial count (microbiology) and subsequent immune response in probiotic inhibition of enterocolitis in children. We try to seek to gain an advanced understanding of probiotics versus pathogenic microorganism and host interactions, and mucosal immune responses to probiotics in the intestine. |
CHIEN-CHANG CHEN; | 2006-02-01 |
| 136 | A Randomized, Double-Blind, Placebo-Controlled, Dose Escalation, In-Patient Phase I/II Study to Determine The Safety and Immunogenicity of Ty800 in Healthy Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to determine whether a new vaccine for typhoid fever is safe and effective. This study will also look at what effects (good and bad) this new vaccine, Ty800, has on the volunteers. The study will determine the highest dose of Ty800 that can be given without causing severe side effects. About 54 healthy males and females, ages 18-45 inclusive, in the Cincinnati metropolitan area will be enrolled in this study. They will be in the study for approximately 7 months, which includes a one month screening period, study product administration on Day 0, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2006-02-01 |
| 137 | Phase I Randomized, Double-Blind, Heterologous Prime-Boost Study of The Safety and Immunogenicity of Vi Polysaccharide Typhoid Vaccine After Priming By Live Attenuated Oral Vi+ Salmonella Typhi Strain CVD 909 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to see if giving a typhoid vaccine by mouth (an experimental vaccine, CVD 909) before giving a vaccine shot (Typhim Vi) will result in a better immune response than giving Typhim Vi vaccine by itself. Another purpose is to see whether CVD 909 is safe. Typhim Vi has been shown to be safe and effective in preventing typhoid fever in older children and adults, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2006-02-01 |
| 138 | Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine, Phase 1 Trial in Adults at NIH CC PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate a new (conjugate) vaccine for typhoid fever, which remains a serious disease especially difficult to treat in developing countries. Salmonella typhi, the bacteria causing typhoid fever, have become resistant to several antibiotics increasing the difficulty of treating the disease. The disease may have serious complications effecting bones, brain, and intestines, with permanent injury or death. Methods to control typhoid fever, such as a sanitary water and food supply, along with effective sewage treatment, are not likely to be available soon in those countries. NIH scientists developed a vaccine called Vi, … |
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT NICHD | 2006-01-09 |
| 139 | The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: All surgical procedures carry with them the risk of infection. Even a minor infection can extend the hospitalization after cardiac surgery. The average minimum increase in length of stay for a single infection is three days. One of the many means used to reduce post-operative infections is the preventative, or prophylactic, administration of antibiotics just before and just after surgery. Because antibiotics, and for that matter surgery itself, alter the body’s natural immune and inflammatory responses and the makeup of the bacteria in the intestine, … |
DAVID S SERES; | 2005-11-01 |
| 140 | A Multicenter, Single-Blind, Placebo-Controlled, Phase 2 Study to Evaluate The Induction of Immunogenicity With Different Doses of Tree MATA in Subjects Allergic to Tree Pollen PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tree MATA (modified pollen allergen tyrosine adsorbate) has been developed to provide pre-seasonal specific immunotherapy for patients with hypersensitivity to tree (birch, alder, and hazel) pollen. Different doses of Tree MATA will be administered and immunological changes following this treatment will be assessed. |
ALLERGY THERAPEUTICS | 2005-07-01 |
| 141 | A Single-Blind Phase I Study to Assess The Residual Allergenicity of Tyrosine Adsorbed Ragweed Pollen Allergoid With MPL Using Skin Prick Testing PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the residual allergenicity of the modified ragweed pollen in Ragweed MATA MPL (modified pollen allergen tyrosine adsorbate + Monophosphoryl Lipid A) by skin prick testing. This is done by a comparison of the wheal response after skin prick testing with different concentrations of aqueous native allergen, modified allergen, modified tyrosine adsorbed allergen, and Ragweed MATA MPL. |
DEEPEN PATEL; | 2005-06-01 |
| 142 | A Double-Blind Phase I Study to Evaluate The Safety and Tolerability of Tyrosine Adsorbed Ragweed Pollen Allergoid With MPL® in Healthy Volunteers Related Papers Related Patents Related Grants Related Experts View Highlight: The safety and tolerability of tyrosine adsorbed ragweed pollen allergoid with monophosphoryl lipid A (MPL) was planned to be evaluated. For this purpose, a total of 4 injections of either increasing doses of the study drug or placebo (tyrosine) was planned to be administered in 7-day intervals to healthy volunteers. |
ALLERGY THERAPEUTICS | 2005-05-01 |
| 143 | A Single-blind Phase I Study to Assess The Residual Allergenicity of Tree (Birch, Hazel and Alder) Pollen Allergoid Using Skin Prick Testing PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the residual allergenicity of Tree MATA (modified pollen allergen tyrosine adsorbate) by skin prick testing. This is done by a comparison of the wheal response after skin prick testing with aqueous native and modified allergen, modified tyrosine adsorbed allergen and Tree MATA MPL (modified tyrosine adsorbed + MPL [Monophosphoryl Lipid A]). |
ALLERGY THERAPEUTICS | 2005-04-01 |
| 144 | A Single-blind Phase 1 Study to Assess The Residual Allergenicity of Grass/Rye Pollen Allergoid Using Skin Prick Testing PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the residual allergenicity of Grass MATA (modified pollen allergen tyrosine adsorbate) by skin prick testing. This is done by a comparison of the wheal response after skin prick testing with aqueous native and modified allergen, modified tyrosine adsorbed allergen and Grass MATA MPL (modified tyrosine adsorbed + MPL). |
MICHAEL J. NOONAN; | 2005-03-01 |
| 145 | A Multicenter, Single-Blind, Placebo-Controlled, Phase 2 Study to Evaluate The Induction of Immunogenicity With Different Doses of Grass MATA in Subjects Allergic to Grass and Rye Pollen PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Grass MATA (modified pollen allergen tyrosine adsorbate) has been developed to provide pre-seasonal specific immunotherapy for patients with hypersensitivity to grass and rye pollen. Different doses of Grass MATA will be administered and immunological changes following this treatment will be assessed. |
PAUL H. RATNER; | 2005-03-01 |
| 146 | Development of An Oral Prime-Boost AIDS Vaccine to Elicit Broadly Neutralizing Antibodies Against HIV-1 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test the safety of and immune response to an oral HIV vaccine in healthy volunteers. The vaccine in this study uses a weakened bacterium called Salmonella typhi to deliver an HIV gene into the body through the mouth. The body then produces an HIV protein from the gene; this protein stimulates an anti-HIV immune response. The vaccine contains only one of the many substances that HIV needs to make more copies of itself, so the vaccine itself cannot cause HIV or AIDS. |
GEORGE K. LEWIS; | 2003-06-09 |
| 147 | Randomized, Double-Blind, Controlled Clinical Trial to Compare Efficacy of A Single Dose of Azithromycin Versus A Single Dose of Ciprofloxacin in The Treatment of Adults With Clinically Severe Cholera Due to V. Cholerae O1 or O139 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cholera remains an important cause of diarrhoeal illness and death in Asia, Africa and Latin America. Antimicrobial therapy is an important adjunct to fluid therapy in the management of patients with cholera, and should be given to all patients with clinically moderate-to-severe disease since they can reduce the diarrhoea duration and stool volume by half. Current therapy for cholera is limited by increasing prevalence of multiply-resistant strains of Vibrio cholerae O1 or O139. Tetracycline and doxycycline had been the drugs of choice for treating cholera, … |
INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH | 2002-12-01 |
| 148 | Oral Rehydration SolutionContaining Amylase Resistant Starch in Severely Malnourished Children With Watery Diarrhoea Due to Vibrio Cholerae PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe malnutrition is associated with a high rate of mortality, even when using the latest WHO recommendations. Watery diarrhea as observed in cholera is an additional vital risk to those children. The fragility of the children together with the complexity of the pathophysiology and the simplicity of the medical environment where the treatment is delivered are serious constraints for the development of new therapies. Dehydration is a special immediate risk in those children who already displayed altered body distribution of water with potassium, magnesium, … |
NUR H ALAM; | 2001-07-01 |
| 149 | A Phase I Trial of A Live, Genetically Modified Salmonella Typhimurium (VNP20009) for The Treatment of Cancer By Intravenous Administration Related Papers Related Patents Related Grants Related Experts View Highlight: RATIONALE: Biological therapies such as VNP20009 use different ways to stimulate the immune system and stop cancer cells from growing. PURPOSE: Phase I trial to study the effectiveness of VNP20009 in treating patients who have advanced solid tumors. |
VION PHARMACEUTICALS | 2000-05-01 |
| 150 | A Phase I Trial of A Live, Genetically Modified Salmonella Typhimurium (VNP20009) for The Treatment of Cancer By Intravenous Administration PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine the safety and toxicities of intravenously administering a genetically modified type of Salmonella bacteria (VNP20009) and its impact on tumor growth in advanced or metastatic cancer (cancer that has spread from the primary site). The first patients in the study will be given the smallest dose of VNP20009, and those who enter later will receive increasingly larger doses. This will be done to determine the maximum dose that can be given without serious side effects. Normally, … |
NATIONAL CANCER INSTITUTE NCI | 2000-03-01 |
| 151 | A Phase I Safety and Immunogenicity Trial of Orally Administered Live Attenuated Recombinant Salmonella Typhi CVD 908 Delta-asd (pW57-asd+) Expressing HIV-1 LAI Gp120 (VVG 203) and Parenterally Administered HIV-1 MN Rgp120 in Alum in HIV-1-Uninfected Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and effectiveness of giving healthy volunteers a new oral HIV vaccine which has been incorporated into a bacterial cell. This oral vaccine (HIV-1 LAI gp120) will be given with or without a different injected HIV vaccine (HIV-1 MN rgp120). Vaccines are preparations that are introduced into the body to try to prevent infection or create resistance to infection. This study examines a new oral vaccine to see if it can improve the immune system’s ability to fight the HIV virus when given alone or with another injected vaccine. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 1999-11-02 |
| 152 | Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for The Treatment of Salmonella Infections in AIDS Patients Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the effectiveness of standard treatment with parenteral ampicillin and oral amoxicillin compared to initial daily therapy with ceftriaxone followed by 3 times weekly suppressive treatment for salmonella infections in AIDS patients. |
UNIVERSITY OF SOUTHERN CALIFORNIA | 1999-11-02 |
| 153 | A Phase I Trial of A Live, Genetically Modified Salmonella Typhimurium (VNP20009) for The Treatment of Cancer By Intratumoral Injection Related Papers Related Patents Related Grants Related Experts View Highlight: RATIONALE: Biological therapies such as VNP20009 use different ways to stimulate the immune system and stop cancer cells from growing. PURPOSE: Phase I trial to study the effectiveness of VNP20009 in treating patients who have advanced or metastatic solid tumors that have not responded to previous therapy. |
VION PHARMACEUTICALS | 1999-08-01 |
| 154 | A Population-Based Case-Control Study of Biliary Tract Cancers in Shanghai, China PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The key aims of this study include estimation of possible risk associated with a history of gallstones, bacterial infection for the biliary tract, other medical history, diet, use of tobacco and alcohol, obesity, reproductive factors, and family history of cancer. Information will be used to examine risk patterns a) seperately by anatomic subsite; b) among patients with gallbladder cancer vs. controls undergoing cholecystectomy for gallstones; … |
JILL E. KOSHIOL; | 1997-05-16 |