Clinical Digest: Recent Clinical Trials on Arthritis
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Arthritis. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Arthritis
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Randomized Trial on The Evaluation of The Effectiveness of One Single Bone Marrow Aspirate Hip Injection Versus Triamcinolone for Hip Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single site, randomized single blinded, two arm study researching the effects of bone marrow aspirate concentrate (BMAC) versus Triamcinolone in patients with hip osteoarthritis. The aims and hypothesis are as follows: Specific Aim 1: Evaluate the change in pain and functional scores of a single bone marrow aspirate injection in comparison to triamcinolone in patients with hip osteoarthritis through validated patient reported outcomes scores at baseline to 12 months (6 weeks, 3 months, 6 months, … |
LEONARDO OLIVEIRA; | 2025-05-01 |
| 2 | Association of Ultrasonographic Temporal Artery Lesions and Relapse in Patients with Giant Cell Arteritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Ultrasound evaluation of the temporal and axillary arteries is currently well recognized in the field of giant cell arteritis (GCA), a disease primarily affecting medium- and large-caliber vessels. Structural ultrasound abnormalities are now well described in this pathology, but their association with relapse and clinical concordance is unknown. There is currently a follow-up score (the OGUS score) for medium- and large-caliber arteries that could also predict the clinical course of the disease. |
UNIVERSITY HOSPITAL BREST | 2025-05-01 |
| 3 | The Effectiveness of Oral Cannabis Extracts for Osteoarthritic Pain: An Internal Pilot, Placebo Controlled, Blinded Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians. Current OA treatments often have limited effectiveness and may cause side effects. As a result, many individuals with OA turn to medical cannabis for pain relief, … |
HANCE CLARKE; | 2025-05-01 |
| 4 | Medium-and Long-term Efficacy of Two Ultrasound-guided Intra-articular Injections of OnabotulinumtoxinA (Botox®) Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis : A Randomized Double-blind Controlled Trial in Three-parallel Arms PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study will be to compare the effects of 2 intra-articular injections of onabotulinumtoxinA with those of 1 intra-articular injection of onabotulinumtoxinA and 1 of normal saline and those of 2 intra-articular injections of normal saline on base-of-thumb pain at 6 months after the first injection. |
CHRISTELLE NGUYEN; | 2025-05-01 |
| 5 | Resorbable Embolization MicroSpheres for OsteoaRthritis Benefit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multi-center, prospective, randomized trial of GAE using Nexsphere-F against steroid injection |
NORTH AMERICAN SCIENCE ASSOCIATES | 2025-05-01 |
| 6 | Pharmacist-physiotherapist Collaborative Management for Early Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is a slowly progressive chronic condition that is associated with aging and is characterized as joint pain. Individuals with early-stage OA usually do not seek medical attention. If and when they do, patients more often present to a pharmacy for over-the-counter medications. The investigators want to leverage community pharmacists’ accessibility and scope of practice to best support patients with early knee OA. Given there are no disease-modifying treatments for OA, treatment guidelines center on patient education, self-management, and exercise, … |
ROSS TSUYUKI; | 2025-05-01 |
| 7 | Study on The Relationship Between Knee Osteoarthritis, Motor Control and The Risk of Falls, and The Effectiveness of Virtual Reality in Managing It in Older People PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about knee osteoarthritis, functionality, and risk of falls in community-dwelling adults aged 60 years and older. The main questions it aims to answer are: * What are the characteristics of a community-dwelling population over 60 years and older in terms of knee osteoarthritis, functionality, and risk of falls? * Does an intervention with virtual reality lower knee osteoarthritis symptoms, raise functionality and prevent falls in community-dwelling adults aged 60 years and older, … |
UNIVERSIDADE DA CORUÑA | 2025-05-01 |
| 8 | Single-dose Intra-Articular of A Hybrid Purified Hyaluronic Acid with A High Molecular Weight and Sodium Chondroitin of Biotechnological Origin in Combination with Rehabilitation Treatment in Sports Adults with Osteoarthritis of The Knee PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: : This observational case-control study aims to evaluate the efficacy of a single-dose intra-articular injection of a hybrid purified hyaluronic acid with high molecular weight and sodium chondroitin of biotechnological origin, combined with rehabilitation treatment, in sports adults with moderate to severe knee osteoarthritis. Additionally, the study incorporates isokinetic testing to assess muscle strength and functional capacity. The primary objective is to determine whether this combined treatment improves pain relief, functional capacity, and overall quality of life compared to rehabilitation treatment alone. Participants aged 18 to 50 years, diagnosed with knee osteoarthritis, … |
PROF.SSA GIULIA LETIZIA MAURO; | 2025-05-01 |
| 9 | The Effect of Omega-3 Fatty Acids in Patients with Rheumatoid Arthritis: A Study Protocol of A Double-blinded Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this double-blinded randomized controlled trial (RCT) was to assess the effect of omega-3 intake versus placebo among patients with RA on the primary outcome of disease activity, and the secondary outcomes of function, fatigue and sleep. This is a prospective, comparative, randomized study, that will be conducted in a single centre (the Rheumatology Department of Charles Nicolle Hospital) during a period of 10 months. This double-blinded RCT will include adult patients diagnosed with RA according to the Association of Rheumatology America (ACR) criteria, … |
SELMA BOUDEN; | 2025-05-01 |
| 10 | A Phase 3, Randomised, Double-Blind, Placebo-Controlled Multi-Centre Study to Evaluate The Treatment Effect of Pentosan Polysulfate Sodium Compared to Placebo in Participants With Knee Osteoarthritis Pain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee OA pain. Study details include: * The study duration will be up to 64 weeks. * The treatment duration will be 6 weeks. * The visit frequency will be twice weekly during treatment. * The visit/contact frequency will be every 4-6 weeks during the 52-week Follow-up period. * Approximately 466 participants will be enrolled into this study. |
PARADIGM BIOPHARMACEUTICALS | 2025-05-01 |
| 11 | Pain Perception During Intra-Articular Knee Joint Injection: What Is The Effect of Needle Gauge and The Use of Ethyl Chloride? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate factors that affect the subjective experience of pain during and after intra-articular knee joint injection of steroids by comparing needle gauge size (22 G vs 25 G needles), as well as the presence or absence of topical ethyl chloride spray. Additionally, this study will investigate the effects of other various factors on patients’ pain associated with the injection. Lastly, … |
DANIEL HERMAN; | 2025-05-01 |
| 12 | Prospective Validation of A Pharmacological Biomarker for Low-Dose Rituximab in Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of the prediction of clinical response to rituximab at a dose of 1000 mg once using a pharmacological model including several pharmacokinetic and pharmacodynamic parameters. |
UNIVERSITY HOSPITAL TOURS | 2025-05-01 |
| 13 | Cellular and Molecular Analysis of Synovial Tissue of Patients With Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to study the inflammatory response in various forms of arthritis. |
DIEGO KYBURZ; | 2025-05-01 |
| 14 | Telehealth Exercise and Mindfulness for Pain in Osteoarthritis: A Stage 1B Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial (RCT) is to test the feasibility of an 10-week telehealth mindful exercise intervention compared to a telehealth exercise only intervention for people with knee osteoarthritis (OA). This RCT will be fully digital with all recruitment, assessments, and intervention being conducted remotely. |
DEEPAK KUMAR; | 2025-05-01 |
| 15 | Comparison of The Effects of Ultrasound-guided Genicular Nerve Block and Conventional Physical Therapy on Pain, Functionality and Balance in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee arthritis is a chronic joint disease that causes pain, disability and impaired quality of life, leading to significant social and health problems worldwide. Moreover, these public and economic impacts related to osteoarthritis of the knee are expected to increase in the future. With the global increase in the proportion of the elderly population, overall obesity rates and the associated incidence of osteoarthritis of the knee, clinicians are now focusing on new treatment strategies. The diagnosis is usually made by history, physical examination and radiography (X-ray) and there is no need for additional examination. Today, … |
HACER IREM ALTAY CAGLAR; | 2025-05-01 |
| 16 | ATP (Adenosine Triphosphate) Concentration Measurement By Phosphorus-31 Spectroscopy in Phosphate Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Phosphate diabetes is defined by urinary phosphate wasting due to impaired tubular reabsorption. It can be classified based on either a genetic or acquired origin. Chronic hypophosphatemia causes rickets in children, leading to growth disorders, bone deformities, and bone pain. In adults, it results in osteomalacia, pseudofractures, as well as muscle fatigue and weakness during exertion. X-linked hypophosphatemia (XLH) is a common cause of hereditary rickets linked to renal phosphate loss due to elevated FGF23 levels, … |
HOSPICES CIVILS DE LYON | 2025-05-01 |
| 17 | Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis – Early Rheumatoid Arthritis Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to assess the feasibility of an intensive, remotely-delivered, combined aerobic and resistance training exercise program for patients with Rheumatoid Arthritis (RA) and to collect data to support power calculations for a larger research study. |
BRIAN J ANDONIAN; | 2025-05-01 |
| 18 | Redefining BMI: The Body, Mind, and Inflammation Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Emerging adulthood (18-25 years of age) is a critical developmental window to promote weight management and cardiometabolic health, particularly for emerging adult women. The primary purpose of this study is to test the preliminary efficacy of the intensive lifestyle intervention for EA women in reducing adiposity, as well as improving biomarkers of inflammation and metabolic risk over 12 months compared with a traditional behavioral weight loss intervention. This treatment program will be tested in emerging adult (EA) women ages 18-25 years old with a BMI of 25-50 kg/m\^2. |
JESSICA LAROSE; | 2025-05-01 |
| 19 | Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using Over The Top Single-bundle Technique and Lateral Extra-articular Tenodesis With Achilles Tendon Allograft PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Several techniques for revision of anterior cruciate ligament (ACL) reconstruction and different types of grafts have been used over the years. These include single-bundle techniques, double-bundle techniques, and single-bundle techniques with external tenodesis. We also distinguish between the use of autografts and grafts from donors, or allografts. The choice of surgical technique and graft type is strongly influenced by the progression of damage characterizing these patients (meniscal, chondral, or ligamentous), the surgical decisions made during the initial surgery (graft used, orientation, and number of bone tunnels), … |
ISTITUTO ORTOPEDICO RIZZOLI | 2025-05-01 |
| 20 | The Role of Vitamin K on Knee Osteoarthritis Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The appropriate form and dosing of vitamin K to benefit relevant outcomes in knee osteoarthritis (OA) are not known. In intervention studies for conditions other than knee OA (e.g., prevention of cardiovascular disease), the most commonly used forms and doses include phylloquinone (vitamin K1; 1000µg or 500µg daily) or menaquinone-7 (MK-7 or vitamin K2; 300µg daily). However, whether these doses are adequate to increase vitamin K to levels that ameliorate risk of adverse OA outcomes is not known. Furthermore, although some studies suggest enhanced bioavailability of MK-7 over vitamin K1, as well as extra-hepatic effects, … |
JEAN LIEW; | 2025-05-01 |
| 21 | Elbow Arthroplasty and Patient Reported Post-operative Activities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients who underwent Total elbow replacement from and after 2010 with a minimum of 6 months at a single institution will be studied retrospectively. The data required for the study will be collected prospectively. Patient demographic data will be collected through the Information team and electronic patient record. Surveys will include questions about whether they recalled the activities that were not recommended by the surgeons, oxford elbow scores and the type of activities they currently perform. Patients will be contacted by telephone after initial screening against inclusion and exclusion criteria, … |
GOPIKANTHAN MANOHARAN; | 2025-04-30 |
| 22 | Real Life Non-interventional Study on Safety and Effectiveness of Ilaris® (Canakinumab) 150 Mg for Subcutaneous Injection in Hereditary Periodic Fever Syndrome (CAPS, CrFMF, TRAPS and HIDS/MKD) Patients and SJIA Patients (REASSURE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to evaluate safety and effectiveness of Ilaris in adult and pediatric patients receiving the drug in a clinical setting for any of the following indications, Hereditary Periodic Fever Syndromes, Cryopyrin-associated periodic syndromes (CAPS), colchicine resistance familial Mediterranean fever (crFMF), TNF receptor associated periodic syndrome (TRAPS), Hyper-IgD syndrome / Mevalonate kinase deficiency (HIDS/MKD) or Systemic juvenile idiopathic arthritis (sJIA). |
NOVARTIS PHARMACEUTICALS | 2025-04-30 |
| 23 | The Impact of Fasting on Disease Activity and The Gut Microbiota in Patients with Psoriasis and Psoriatic Arthritis – The RiseFast Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The RiseFast pilot study will investigate the clinical, metabolic and immunological effects of fasting and plant-based diet (PBD) on patients with psoriasis (PsO) and psoriatic arthritis (PsA) on their gut microbiota. The project will combine clinical assessments, cytometric profiling, and gut microbiota analysis to explore the relationship between fasting, a plant-based diet, and psoriatic disease. The study includes a 7-day fasting period followed by 11 weeks of PBD, with the goal of improving disease activity, quality of life, and understanding the role of gut microbiota in these conditions. This approach could lead to low-cost, … |
ANIKA RAJPUT KHOKHAR; | 2025-04-30 |
| 24 | Comparison Between The Effects of Two Different Muscle Energy Techniques on Hamstring Flexibility in Patients with Hamstring Tightness Secondary to Knee Osteoarthritis: Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The current study will compare the effect of using the muscle energy technique in 2 different methods on the hamstring muscle flexibility |
HISHAM MOHAMED HUSSEIN; | 2025-04-30 |
| 25 | CHAT-OA: Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the use of a generative artificial intelligence large language model chatbot in improving decision making factors in patients with hip and knee osteoarthritis. The main questions it aims to answer are: Does the use of an artificial intelligence chatbot have an effect on decisional conflict and anxiety related to decision making? Are changes in decisional conflict correlated with changes in patient reported outcomes? Are changes in decisional conflict correlated with health literacy? Participants will interact with an artificial intelligence chatbot prior to their clinic visit with an orthopaedic surgeon, … |
ZACHARY C LUM; | 2025-04-28 |
| 26 | Evaluation of The Effect of Vitamin E (α-tocopherol) Supplementation on Clinical Activity and Inflammation in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this clinical trial is to determine whether α-tocopherol (vitamin E) supplementation decreases inflammation and clinical activity in patients with rheumatoid arthritis (RA).The main questions to be answered are: * Is supplementation with vitamin E (α-tocopherol) for one month associated with decreased clinical activity and inflammation in patients with RA? Researchers will compare α-tocopherol with a placebo (a look-alike substance containing no active ingredient) to see if α-tocopherol effectively reduces inflammation and clinical activity in patients with rheumatoid arthritis. Participants will: * Take two capsules (one in the morning and one in the afternoon) of either α-tocopherol or placebo every day for a month. * Attend clinic visits at the start of the intervention (baseline) and at the end of the month for final check-ups and tests. * Keep a diary to record your symptoms and how often you take α-tocopherol or placebo. |
CHRISTIAN JOHANA J BAÑOS HERNÁNDEZ; | 2025-04-28 |
| 27 | FAldini Sport Total Joint Arthroplasty-Knee II: Toward Rehabilitation of Sports Activity Following Total Knee Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The majority of patients undergoing total knee arthroplasty are elderly individuals with low functional demands, aiming to alleviate pain. However, there exists a subgroup of younger patients, under the age of 65, with higher functional demands. The purpose of this study is to evaluate the return to sports activities in this patient group following a non-cemented total knee arthroplasty procedure and a specific rehabilitation protocol. The investigators expect that with the use of non-cemented prostheses and a specific rehabilitation protocol, many of these patients will safely resume sports activities. |
ISTITUTO ORTOPEDICO RIZZOLI | 2025-04-26 |
| 28 | Optimal High-Intensity Laser Therapy (HILT) Parameters for Pain and Function in Patients With Moderate Knee Osteoarthritis: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to find the best settings (dose) for High-Intensity Laser Therapy (HILT) to reduce pain and improve function in people with moderate knee osteoarthritis. Participants will be randomly assigned to receive one of three different doses of HILT (low, medium, or high) or a sham (placebo) laser treatment, three times a week for four weeks. The main outcomes measured will be changes in knee pain (using a pain scale) and knee function (using a questionnaire) from the beginning to the end of the 4-week treatment period. |
AL HAYAH UNIVERSITY IN CAIRO | 2025-04-23 |
| 29 | Ambispective, Non-Interventional Study to Evaluate The Epidemiology of Interstitial Lung Diseases (ILDs) Associated to Rheumatic Diseases (Rheumatoid Arthritis, Connective Tissue Diseases, Spondylarthritis and Sarcoidosis) and The Progression Risk Factors in The Mexican Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to characterize the epidemiology of interstitial lung diseases (ILD) associated to connective tissue disease (CTD) in Mexico, and to study its correlation with the different comorbidities and treatments used, as well as the possible impacts of these factors on the outcome of progression, exacerbations, and mortality in patients with ILD associated to CTD. |
BOEHRINGER INGELHEIM | 2025-04-21 |
| 30 | Trapeziectomy and Suture Suspensionplasty for Thumb Carpometacarpal Arthritis – Is In-Clinic Therapy Needed? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a randomized, controlled trial to evaluate the efficacy of formal occupational therapy on outcomes following CMC arthroplasty |
JULIE NUELLE; | 2025-04-17 |
| 31 | Randomized,Double-blind,Placebo,Positive-controlled Phase III Trial of VDJ001 In Patients With Moderate-to-severe Active Rheumatoid Arthritis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A multicenter, randomized, double-blind, placebo-controlled, and active drug-controlled Phase III pivotal clinical trial of recombinant humanized anti-interleukin-6 receptor monoclonal antibody injection (VDJ001) for the treatment of moderate-to-severe active rheumatoid arthritis with poor response to methotrexate |
BEIJING VDJBIO | 2025-04-15 |
| 32 | A Phase 2 Multicenter, Randomized, Platform Study of Targeted Therapies for The Treatment of Adult Subjects With Active Psoriatic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriatic arthritis (PsA) is a type of arthritis that happens when the body’s immune system attacks healthy cells and tissues causing joint pain, stiffness, and swelling. Symptoms can get worse and go away for periods of time. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies, for the treatment of active psoriatic arthritis and to assess the changes in disease symptoms. The therapies being assessed in this sub-study are risankizumab and lutikizumab. Participants will be randomized in a 1:1:1 ratio to one of the three treatment arms: lutikizumab monotherapy, … |
ABBVIE | 2025-04-15 |
| 33 | A Randomized, Double-Blind, Placebo-Controlled, Parallel Design Clinical Study to Evaluate The Efficacy of Native CT-II® in Individuals With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized, double-blind, placebo-controlled clinical study evaluates the efficacy of Native CT-II® (undenatured type II collagen) in individuals with knee osteoarthritis using a parallel design.Participants are assigned to one of three groups: Group 1 receives Native CT-II® (40 mg daily individed doses), Group 2 receives Glucosamine HCL + Chondroitin Sulphate (2700 mg daily as acomparator), and Group 3 receives a placebo (Microcrystalline Cellulose). All participants take threecapsules after breakfast and three after dinner for 90 days . The study aims to screen approximately 142 participants , randomizing around 114 (considering a 20% dropout rate), … |
VEDIC LIFESCIENCES PVT | 2025-04-15 |
| 34 | Cross-cultural Adaptation and Validation of A Turkish Version of The Arthritis Self-Efficacy Scale-8 (ASES-8) for Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Self-efficacy is a psychosocial construct that reflects an individual’s confidence in their ability to perform specific tasks, focusing more on one’s belief in their abilities than on actual performance. This concept is especially important in knee osteoarthritis (KOA) management, as it can significantly influence overall health and treatment outcomes, and it is considered a modifiable trait. KOA is one of the most common musculoskeletal disorders worldwide, substantially impacting quality of life due to symptoms such as limited mobility, chronic pain, and joint stiffness. These symptoms can hinder daily activities and potentially lead to social isolation. In patients with KOA, … |
BEZMIALEM VAKIF UNIVERSITY | 2025-04-15 |
| 35 | Bone Marrow Aspirate Injections in Knee Arthroscopy: A Randomized, Single-Blind, Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or cartilage damage. Like flipping a coin, patients will be randomly assigned to one of two groups of 25 patients each. One group will receive standard arthroscopic surgery plus an injection of bone marrow aspirate, while the other group will receive standard surgery plus a saline (salt water) injection. During surgery, for patients in the treatment group, … |
ANIL S RANAWAT; | 2025-04-15 |
| 36 | Role of Wild Blueberries in Mitigating Pain and Inflammation in Knee Osteoarthritis and Rheumatoid Arthritis and in Modifying Gut Microbiome As A Disease Mechanism: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Arthritis, an inflammatory condition characterized by pain, redness, heat and swelling in joints, is the leading cause of disability and reduced quality of life in US adults, and accounts for the highest total health care spending in the US. Among all foods, dietary berries including blueberries have been associated with improved cardiometabolic biomarker score in a seven-year national survey in US adults, and thus blueberries warrant further investigation for these chronic conditions. This forms the scope of this RCT using wild blueberries in adults with arthritis and examining the gut microbiome as a mediating mechanism of their effects. |
ARPITA BASU; | 2025-04-15 |
| 37 | Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy: Effectiveness of 5 Nerve Protocols Versus 3 Nerve and 2 Nerve Protocols – A Prospective Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic. Current conservative treatments have moderate effects on chronic knee pain and their use is limited due to the risk of side effects. In addition to pain, patients also experience other symptoms. As a result of the osteoarthritis process, prorioception in the knee is impaired with a decrease in mechanoreceptors, resulting in loss of balance and an increase in the risk of falling. |
BENGU TUREMENOGULLARI; | 2025-04-15 |
| 38 | Evaluation of Liver Fibrosis and Hepatic Steatosis Using FIB-4 Score and Ultrasonography in Psoriatic Arthritis Patients Treated With TNF or IL-17 Inhibitors: A Retrospective Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriatic arthritis (PsA) is an inflammatory joint disease that can also affect the liver. Some medications used to treat PsA, such as biological agents (TNF-alpha inhibitors and IL-17 inhibitors), … |
MEHMET SERKAN KILIÇOĞLU; | 2025-04-10 |
| 39 | Reliability and Validity of The Glittre Activities of Daily Living Test in Children and Adolescents With Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Juvenile Idiopathic Arthritis (JIA) is children’s most common inflammatory rheumatic disease. The International League of Associations for Rheumatology (ILAR) defines it as a chronic arthritis condition that begins before the age of 16 lasts for six weeks or more, and has an unknown cause. Despite the gains made in the management of the disease of individuals with JIA with modern medical treatment methods, the physical and psychosocial problems caused by chronic inflammation negatively affect the daily living activities of individuals with JIA. On the other hand, in the JIA Core Set created by Outcome Measures in Rheumatology (OMERACT) in 2018, … |
SINAN BURAN; | 2025-04-10 |
| 40 | A Phase Ⅰ, Randomized, Double-Blind, Placebo-Controlled Dose Escalation Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SHR-3045 in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SHR-3045 in healthy subjects. |
XUEYING DING; | 2025-04-08 |
| 41 | Gemelli Longitudinal Cohort on Long-term Outcomes in RheumatIc DiseAses PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic rheumatic diseases (CRDs) are major determinant of disability in the general population. Particularly, immune-mediated CRDs also represent a significant cause of morbidity and mortality among younger individuals. CRDs lead to substantial direct costs related to healthcare service use and pharmacological expenses, … |
MARIA ANTONIETTA D’AGOSTINO; | 2025-04-07 |
| 42 | Remote Tai Chi for Knee Osteoarthritis: An Embedded Pragmatic Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pragmatic randomized trial is to evaluate the effectiveness of remote Tai Chi to treat knee pain in adults with knee osteoarthritis. The main questions the trial aims to answer are: * Compared to routine care, will patients with Knee OA receiving remote Tai Chi exhibit greater improvement in knee-related pain (WOMAC pain score, primary outcome), pain interference (PROMIS-Pain Interference, secondary outcome), … |
CHENCHEN WANG; | 2025-04-07 |
| 43 | Pain Reprocessing Therapy in Post-Operative Knee Pain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery. The study is comparing PRT to usual care (the regular treatment people get after surgery) to see which works better for relieving pain. The main questions the study aims to answer are: 1. Does PRT help lower pain in people who have chronic knee pain after knee surgery? 2. How do the effects of PRT compare with usual care in terms of pain relief and other factors such as anxiety, depression, … |
YONI ASHAR; | 2025-04-07 |
| 44 | An Open Label Phase IIb Study to Evaluate Safety and Tolerability of OA-SYS in Subjects with Moderate to Severe Osteoarthritis of The Knee Joint PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being conducted to evaluate the safety and tolerability of OA-SYS in patients with moderate to severe OA of the knee joint. |
AGELESS BIOTECH | 2025-04-02 |
| 45 | Ultrasonication-mediated Microbubbles Dressings Increase The Therapeutic Efficacy of Piroxicam Gel for Hand Arthritis: Assessments Using Conventional and Ultrafast Power Doppler Imaging PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if ultrasonication-mediated microbubbles dressing works to treat hand arthritis in adults. It will also learn about the safety of ultrasonication-mediated microbubbles dressing. The main questions it aims to answer are: Does ultrasonication-mediated microbubbles dressing increase the therapeutic efficacy of piroxicam gel for hand arthritis? Researchers will compare ultrasonication-mediated microbubbles dressing + piroxicam gel to ultrasonication + piroxicam gel and piroxicam gel alone to see if ultrasonication-mediated microbubbles dressing works to treat hand arthritis. Participants will: Take ultrasonication-mediated microbubbles dressing (day 1,3,5) + piroxicam gel (day 2,4,6,7) , … |
KUO-LUNG LAI; | 2025-04-02 |
| 46 | Implementing A Guideline-based Model of Care for Hip and Knee Osteoarthritis in Finland. A Benchmarking-controlled Trial (FIN-OA) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to bridge the gap between guideline recommendations and clinical practice in osteoarthritis (OA) management. By implementing a systematic, evidence-based model of care, the project seeks to improve patient outcomes, reduce healthcare costs, and provide equitable access to care. The project consists of three phases. In the first phase the current OA care is mapped through registry review and questionnaires and interviews of patients and healthcare professionals. In the second, implementation phase of the project, … |
RIIKKA HOLOPAINEN; | 2025-04-01 |
| 47 | Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term of NRS pain score. The participants will be evaluated by numeric rating scale and oxford knee score for assessment of pain relief up to 16 weeks. |
AHMED BOEITH; | 2025-04-01 |
| 48 | Randomized, Controlled, Multi-center Phase II Clinical Trial for The Treatment of Patellofemoral Osteoarthritis With Nasal Chondrocyte-based Tissue Engineered Cartilage Implantation Vs Current Standard of Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ENCANTO is a randomized, controlled, multi-center phase II clinical trial for the treatment of patellofemoral osteoarthritis (PFOA) with an Advanced Therapy Medicinal Product (ATMP), nasal chondrocyte-based tissue engineered cartilage (N-TEC) implantation in comparison with current standard of care depending on the stage of osteoarthritis. The goal of this phase II trial is to evaluate the efficacy of N-TEC treatment in comparison to an active comparator Autologous Matrix Induced Chondrogenesis (AMIC) for early stage PFOA or patellofemoral arthroplasty (PFA) for late stage PFOA. The N-TEC engineered cartilage graft is obtained by culturing expanded autologous nasal chondrocytes within a collagen type I/III membrane. |
UNIVERSITY HOSPITAL BASEL SWITZERLAND | 2025-04-01 |
| 49 | A Randomized, Double-Blind, Multi-Site Placebo Controlled Trial of Colchicine in Calcium Pyrophosphate Deposition Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if colchicine reduces levels of proteins indicating inflammation in the blood in individuals with calcium pyrophosphate deposition (CPPD) disease. The trial will also test the effect of colchicine on joint symptoms in CPPD disease. The main questions it aims to answer are: * Does colchicine reduce the level of interleukin 18 (IL-18) in the blood of individuals with CPPD disease? * Does colchicine reduce pain scores in individuals with CPPD disease? Researchers will compare colchicine once daily to a placebo (a look-alike pill that contains no drug) to see if colchicine works to treat CPPD disease. Participants will: * Take colchicine or a placebo every day for 6 months * Visit the clinic 3 times in 6 months for joint examinations, surveys, and blood tests. Each visit will last 2-3 hours. * Speak on the telephone with researchers for about 4 times over 6 months. Each phone call will last about 5 minutes. |
SARA TEDESCHI; | 2025-04-01 |
| 50 | Evaluation of Articular Damage in Patients With Juvenile Idiopathic Arthritis (JIA) After Transition to Adult Care and Correlation With Disease Characteristics and Treatments PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Juvenile idiopathic arthritis (JIA) is the most common childhood chronic rheumatic disease, encompassing all forms of arthritis that persist for more than 6 weeks, with onset before age 16, after exclusion of other causes of arthritis. It is a heterogeneous disease, whose complexity is only partially encompassed by the actual classification criteria and it is characterized by prolonged synovial inflammation that can lead to joint destruction. Whilst the assessment of structural joint damage is part of the routinary evaluation of disease severity and progression in patients with rheumatoid arthritis (RA), … |
IRCCS BURLO GAROFOLO | 2025-04-01 |
| 51 | Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee Osteoarthritis – Randomized Controlled Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PRP+HA-23 is a double-blind randomized controlled clinical trial with 1:1:1 allocation. The objective of the study is to evaluate by a randomized controlled, double-blind clinical trial the efficacy and safety of viscosupplementation-associated PRP infiltration compared with PRP-only or HA-only infiltration for the treatment of patients with knee osteoarthritis. |
DAVIDE REALE; | 2025-04-01 |
| 52 | A Randomized, Double-Blind, Parallel-Controlled, Multicenter Clinical Trial of Antarctic Krill Oil in The Management of Knee Osteoarthritis Pain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effectiveness and safety of Antarctic Krill Oil (AKO) as a dietary supplement in managing pain associated with knee osteoarthritis (OA). The main questions it aims to answer are: ①Does AKO reduce daily pain intensity in participants with moderate knee OA? ②What adverse effects do participants experience when taking AKO? Researchers will conduct a randomized, double-blind study comparing AKO to a placebo (identical appearance without active components) to assess: * Changes in joint pain severity; ②Functional improvement in daily activities; ③Biochemical safety parameters,etc. |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2025-04-01 |
| 53 | Comparison of Denervation Techniques for The Treatment of Knee Osteoarthritis: A Randomized Clinical Trial of Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies. The study evaluates the effectiveness and safety of continuous ablative radiofrequency, which uses heat energy to disrupt pain signals, and chemical denervation with absolute alcohol, which involves an injection to reduce pain transmission. Participants will be randomly assigned to one of the treatments, and their pain levels, mobility, and quality of life will be monitored over time to determine which method provides better pain relief. |
LEONARDO HENRIQUE CUNHA FERRARO; | 2025-04-01 |
| 54 | Examination of The Dose Response Relationship Between Physical Activity and Arthritis-Attributable Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to see examine the effects of 3 different levels of physical activity (45 minutes/week, 90 minutes/week, or 150 minutes/week) on arthritis symptoms. |
CHRISTINE A PELLEGRINI; | 2025-04-01 |
| 55 | Effectiveness of Muscle Energy Techniques and Mulligan Mobilization Along With Conventional Physical Therapy in Knee Joint Osteoarthritis Patients: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effectiveness of integrating Muscle Energy Technique (MET) and Mulligan Mobilization with conventional physical therapy in the management of knee osteoarthritis (OA), with a specific focus on improving hamstring flexibility and reducing functional limitations. The findings will help inform clinical decision-making and enhance patient outcomes in OA rehabilitation. |
BABAR ISRAR; | 2025-04-01 |
| 56 | A Randomized, Double-Blind, Phase 2, Efficacy and Safety Cross-Over Study of Allogeneic HB-adMSCs Vs Placebo for The Treatment of Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Methodology: Randomized, double-blind, AB/BA cross-over study with a washout period of 12 weeks. Treatment Duration: 8 weeks per group General Objectives: To assess the efficacy and safety of multiple intravenous infusions of allogeneic HB-adMSCs by improving signs and symptoms of juvenile idiopathic arthritis in this subject population. Number of Subjects: 66 (6 subjects in Cohort 1 and 60 subjects in Cohort 2) Indication: Juvenile Idiopathic Arthritis |
THANH CHENG; | 2025-04-01 |
| 57 | Combining Virtual Reality and Hypnosis to Alleviate Chronic Pain in Elderly Patients with Hand Arthritis: A Pilot Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot randomized clinical trial is to test the efficacy of an intervention combining virtual reality and hypnosis on decreasing pain and improving quality of life in elderly patients with hand arthritis. The main questions it aims to answer are: * Does the intervention allow for an improvement of patient reported outcomes related to pain and quality of life? * Does the intervention allow for an improvement of physiological variables related to pain? Researchers will compare intervention group to a passive control group (i.e., … |
CIUSSS DE L’EST DE L’ÎLE DE MONTRÉAL | 2025-04-01 |
| 58 | Demographic Data and Clinical Presentation of Pediatric Uveitis Patients in Upper Egypt PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To describe and analyze the demographics, Clinical characteristics, etiology, and visual outcomes of pediatric uveitis cases attending the outpatient clinic of Ophthalmology department, Assiut University Hospital. |
HASNAA SALAH EBRAHIM ABO ELYUON; | 2025-04-01 |
| 59 | A Phase 1/2a, Multicenter, Randomized, Controlled, Single-Blind, Dose-Finding Study to Evaluate The Safety and Efficacy of Cryopreserved Devitalized Adipose Tissue Allograft (BRC-OA) for Pain Treatment in Subjects With Mild to Severe Osteoarthritis (OA) of The Knee PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety profile of BRC-OA for pain treatment in patients with mild to severe OA of the knee, focusing particularly on two distinct doses. Alongside safety assessments, the study also aims to investigate the initial efficacy of BRC-OA in treating pain among these patients. The study product is a cryopreserved devitalized adipose tissue allograft (BRC-OA). BRC-OA is composed of a devitalized human adipose particulate that retains the inherent properties of adipose such as tissue architecture, extracellular matrix, and signaling molecules. |
BRITECYTE | 2025-04-01 |
| 60 | Early Feasibility Study of Cartilage Defect Repair PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Any patient aged 14 or older up to 55 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed conservative care, and is a candidate for surgical intervention to treat. |
CYTEX THERAPEUTICS | 2025-04-01 |
| 61 | Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot study aims to investigate the viability of using a smartwatch-based electrodermal activity (EDA) sensor to capture enough EDA signal to quantitatively assess pain in osteoarthritis subjects and test the feasibility of its methods and procedures for later use in subsequent larger-scale studies. |
PETER L. SCHILLING; | 2025-04-01 |
| 62 | Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Recruiting will be performed via checking the calendar for scheduled TKA procedures in the \> 8 weeks by clinical staff in the UAMS orthopedic clinic. Clinic staff will look for basic inclusion/exclusion criteria in the EMR for those patients. Clinic staff will either contact directly or send contact information to the PI of this study to contact for recruitment purposes. During the initial phone call, … |
UNIVERSITY OF ARKANSAS | 2025-04-01 |
| 63 | Effects of Postural Corrector and Activity Tracker for Enhanced Post-operative Rehabilitation of Total Knee Replacement PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: * To assess the impact of postural corrector on post-operative knee function and activity * To evaluate the role of activity tracker in monitoring and enhancing post-operative rehabilitation * To assess the effects of postural corrector and activity tracker on pain management during rehabilitation |
AYESHA SADIQ; | 2025-04-01 |
| 64 | Analysis of The Pathophysiological and Functional State of The Knee Joint PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis is the most common degenerative condition affecting the knee joint globally, with an incidence of about 7% of the population. In Italy, it affects approximately 3.9 million people, with a direct treatment cost of around €2.5 billion. At the joint level, osteoarthritis manifests with pain and reduced functionality, worsening as the disease progresses and severely limiting knee movement. Compounding this, osteoarthritis can impact both elderly and younger individuals due to traumatic factors. Despite its significant impact, effective treatments for osteoarthritis that address its underlying causes are still lacking, focusing mainly on symptom management. Therefore, … |
STEFANO ZAFFAGNINI; | 2025-04-01 |
| 65 | A Prospective, Single-arm, Multinational, Multi-center, Clinical Study to Evaluate The Performance and Safety of Musculoskeletal Embolization Using NBGM200 in Patients With Knee Degenerative Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study in patients with knee osteoarthritis treated by embolization using NBGM200 |
NEXT BIOMEDICAL | 2025-04-01 |
| 66 | Impact of Ultra-processed Foods in A Population of Patients With Chronic Rheumatic Diseases (Rheumatoid Arthritis, Spondyloarthritis, Osteoarthritis) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Ultra-processed foods (UPF) represent one of the mainstays of today’s diet. They are defined by the NOVA classification system. It was demonstrated that UPF consumption was associated with activity of inflammatory bowel diseases with underlying mechanisms not fully identified yet. It is suspected that UPF constituents could modify the gut microbiota, increase intestinal barrier permeability and directly engage immune surveillance systems, effects that could individually or synergistically increase the risk of immunomediated diseases. As some pathophysiological mechanisms are shared among IBD and rheumatic diseases, … |
MAXIME AUROUX; | 2025-03-31 |
| 67 | The Effect of Non-steroidal Anti-inflammatory Drug (NSAID) Use on The Efficacy of Dextrose Prolotherapy in The Treatment of Knee Osteoarthritis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our purpose is to expand upon the results of the pilot study performed at David Grant Medical Center (DGMC) which showed that concomitant non-steroidal NSAID use in adults with knee osteoarthritis (OA) undergoing a three-shot dextrose prolotherapy (DPT) injection series did not negate the efficacy of DPT. Additionally, it showed that giving both treatments simultaneously is safe and efficacious. The small sample size and design of the pilot study limited the conclusions that can be drawn on the concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) during DPT treatment. This is a double-blinded, randomized, … |
ALEXANDER R KIM; | 2025-03-31 |
| 68 | A Randomized Controlled Clinical Trial Investigating The Effects of The Digital App Rheumabuddy4.1 in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid arthritis (RA) is one of the most frequently occurring autoimmune rheumatic diseases, affecting an estimated 1% of the global population. RA is a chronic inflammatory disease that leads to the development of synovial inflammation and effusion, ultimately followed by joint destruction and permanent disability. The substantial socioeconomic burden and the challenge of RA patients adhering to treatment is an important factor of this disease and its impact on both patients and society. An innovative approach is needed in order to find new ways to assist and truly empower patients to understand their disease, … |
HENNING BLIDDAL; | 2025-03-31 |
| 69 | Effect of Retro-walking Versus Forward-walking Training Using Underwater Treadmill on Pain and Function in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study Will investigate and compare the effects of retro-walking and forward-walking underwater treadmill training on pain, function and ROM in subjects with chronic knee OA |
NOURHAN ATWA SAID; | 2025-03-30 |
| 70 | Assessment of Platelet Rich Plasma with Injectable Platelet Rich Fibrin VS Platelet Rich Plasma Vs Platelet Rich Fibrin in Management of Temporomandibular Joint Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Studying effectiveness of prp with prf comparing with prp or prf for mangement of tmj osteoarthritis as result in pain and mandibular movement in adult pt |
ALIAA BABEKIR AHMED MOHAMED; | 2025-03-29 |
| 71 | A Randomized Double-Blinded and Placebo-Controlled Trial to Assess The Impact of Biophoton Therapy on Chronic Severe Arthritis Pain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study Objective The purpose of this clinical study is to evaluate if biophoton therapy, delivered by Tesla BioHealing® Biophoton Generators (Biophotonizer), can alleviate chronic severe pain. Study Design This is a randomized, double-blinded, placebo-controlled intervention clinical study to assess the effectiveness of biophoton therapy in managing chronic severe pain. Approximately 102 patients with chronic severe arthritis pain will participate in the study. Study Randomization The biostatistician will prepare a randomization schedule including a series of subject numbers. A subject number will be randomly assigned to each study participant, … |
FIRST INSTITUTE OF ALL MEDICINES | 2025-03-28 |
| 72 | Genicular Artery Embolization (GAE) Vs InTra-articular Corticosteroid Injection for Osteoarthritic Knee Pain. (GET-IN Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates genicular artery embolization (GAE) as a minimally invasive alternative to ntra-articular corticosteroid injections (IA) or treating knee osteoarthritis (OA) pain. Designed as a randomized controlled tria, the study compares pain relief effectiveness and safety between GAE and IA over a 12-month follow-up. Eligible participants are aged over 40 with symptomatic knee OA resistant to conservative treatment. Primary outcomes focus on pain reduction (NRS score), while secondary measures include function, quality of life, imaging findings, and adverse events. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2025-03-25 |
| 73 | Applications of Ultrasound and Physical Parameters in Assessing Fall Risk Among Patients With Knee Osteoarthritis: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Falls are a significant issue for patients with knee osteoarthritis, as they can lead to hospitalization or even more severe consequences. Therefore, it is crucial to assess fall risk early in rehabilitation clinics. Sarcopenia, which is the reduction of muscle mass, increases the risk of falls. This study involved 250 adults with knee osteoarthritis, using a technology called POCUS to assess muscle mass, … |
NATIONAL TAIWAN UNIVERSITY CLINICAL TRIAL CENTER | 2025-03-24 |
| 74 | Investigation of Postural Parameters, Physical Functions, Balance and Quality of Life in Different Hip Pathologies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is known that pelvic parameters affect physical hip functions in hip pathologies. Depending on the type and severity of hip pathologies, posture, muscle strength, balance, and pain parameters may change, thereby impacting an individual’s quality of life. This study aimed to examine the postural parameters, muscle strength, balance, quality of life, pain intensity, and pain localization of individuals with different hip pathologies, including hip osteoarthritis, hip impingement syndrome, hip labrum tear, hip dysplasia, and hip avascular necrosis. |
ESRA ATEŞ NUMANOĞLU; | 2025-03-20 |
| 75 | Segurança E Eficácia De Nova Abordagem Ecoguiada De Ablação Por Radiofrequência Dos Nervos Geniculados PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research team is doing a study to learn more about a new way to treat long-term knee pain caused by joint damage. They are using a treatment called radiofrequency ablation (RFA). This is a procedure where doctors use heat to stop certain nerves from sending pain signals. In this study, doctors will use ultrasound to guide a small needle to nerves around the knee, called genicular nerves. Then, … |
MANUEL TOMÁS FARINHA CAROÇO; | 2025-03-20 |
| 76 | A Phase 2a, Single-Arm Study to Investigate The Efficacy and Safety of LY3541860 in Adult Participants With Moderately to Severely Active Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the effects of LY3541860 in adult participants with moderately to severely active Rheumatoid Arthritis with inadequate response to a least one biologic disease-modifying antirheumatic drug (bDMARD)or targeted synthetic disease-modifying antirheumatic drug (tsDMARD). Study participation is approximately 50 weeks, including a 6-week screening period, 24-week treatment period, and a 20-week safety follow up period. |
JOHN TESSER; | 2025-03-19 |
| 77 | Pivotal, Prospective, Randomized, Controlled, Multicenter Clinical Trial of BioPoly® Partial Resurfacing Knee Implant for Treatment of Focal Cartilage Lesions of The Distal Femur PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients with knee pain and symptoms who are candidates for surgical intervention of the knee compared to outcomes for the control group. The primary effectiveness endpoint is Month 24 composite clinical success (CCS) defined by: * no secondary surgical intervention (SSI) and * an improvement from baseline in the Knee injury and Osteoarthritis Outcome Score (KOOS) total score (scaled 0 to 100) of at least 10 points. Researchers will compare the CCS for the investigational device group to a control group receiving the standard of care, either microfracture or debridement). Subjects randomized to the investigational group will receive the BioPoly Knee device and those randomized to the control group will receive the current standard of care, either microfracture or debridement. |
IAN NELSON; | 2025-03-17 |
| 78 | A Randomized Controlled Phase L Clinical Study to Evaluate The Efficacy, Safety, Tolerability and Pharmacokinetics/Pharmacodynamics of GNC-038 Tetra-specific Antibody Injection in Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized controlled phase I clinical study with safety, efficacy, and pharmacokinetic/pharmacodynamic characteristics in patients with rheumatoid arthritis. |
SHUANG YE; | 2025-03-17 |
| 79 | Cross-validation of A Predictive Model of Response to Anti-TNF Alpha Based on Oxylipin Response in Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to use a blood test to predict whether a participant diagnosed with rheumatoid arthritis will respond to anti-TNF alpha treatment . The main questions it aims to answer is: Is the predictive model created using oxylipins effective? Participants starting anti-TNF alpha treatment will have a blood sample taken before starting treatment and 6 months afterwards. |
ANNE TOURNADRE; | 2025-03-15 |
| 80 | A Phase 3, Multicenter, Double-blind, Placebo-controlled, Randomized Withdrawal Trial to Evaluate The Efficacy, Safety, and Pharmacokinetics of Deucravacitinib in Children and Adolescents From 5 to Less Than 18 Years of Age With Active Juvenile Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the drug levels, efficacy, and safety of Deucravacitinib (BMS-986165) in pediatric participants with juvenile psoriatic arthritis. |
BRISTOL MYERS SQUIBB | 2025-03-13 |
| 81 | The Relationship Between Physical and Psychosocial Status and Irisin Level in Individuals with Knee Osteoarthritis Performing Brisk Walking Exercise PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this prospective randomised controled study is to investigate the effect of 8-weeks brisk walking exercise on irisin levels, physical and psychosocial parameters in individuals with knee osteoarthritis, and the relationship between irisin levels and physical and psychosocial parameters. The main question it aims to answer is: does 8-weeks brisk walking exercise increase irisin levels and imoroves physical and psychosocial parameters and is the irisin level in relation with the physical and psychosocial parameters. |
ÜMMAHANI KUŞ; | 2025-03-13 |
| 82 | Electromagnetic Transduction Therapy (EMTT) on Mid-foot Osteoarthritis: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if Electromagnetic Transduction Therapy (EMTT) is a viable treatment option in patients with osteoarthritis of the foot and/or ankle. |
ELIZABETH BONDI; | 2025-03-13 |
| 83 | Open-Label, Single-Arm Trial to Evaluate The Pharmacokinetics and Safety of Bimekizumab in Pediatric Study Participants From 2 to Less Than 18 Years of Age With Active Juvenile Idiopathic Arthritis Subtypes Enthesitis-Related Arthritis (Including Juvenile-Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess plasma bimekizumab concentrations following subcutaneous (sc) bimekizumab administration. |
UCB BIOPHARMA SRL | 2025-03-11 |
| 84 | An Open-label, Long-term Extension Clinical Study to Evaluate The Safety, Tolerability, and Efficacy of TLL-018 in Patients With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to evaluate the long-term safety, tolerability, and efficacy of TLL-018 in patients with rheumatoid arthritis (RA) who have completed a preceding randomized controlled trial with TLL-018. |
HANGZHOU HIGHLIGHTLL PHARMACEUTICAL | 2025-03-10 |
| 85 | Capsaicin in Digital Osteoarthritis Versus Control : A Randomized Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this multicentric, randomized controlled double-blind clinical trial is to demonstrate the efficacy of transdermal application of capsaicin in patients with painful digital osteoarthritis with a neuropathic pain component. Participants will receive either a transdermal patch of capsaicin 179 mg (8%) or the control treatment (capsaicin 0.04%). Researchers will compare the intensity of pain in the fingers at day 60 in the capsaicin 8% group versus capsaicin 0.04% (control arm) |
SYLVAIN MATHIEU; | 2025-03-07 |
| 86 | A Phase 4, Prospective, Open-Label, Single-Arm Study to Assess The Effectiveness of Tirzepatide After Initiation of Ixekizumab in Adult Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe PsA and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months. |
ANDREW SHAROBEEM; | 2025-03-06 |
| 87 | Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient and Its Relation With Response to Methotrexate PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriasis is a chronic, immune-mediated, multisystemic, inflammatory disease caused by the interaction of multiple susceptibility genes and environmental factors that affects 1-3% of the population worldwide .Psoriasis also is a chronic inflammatory skin disease characterized by scaly indurated erythema. Psoriatic arthritis (PsA) is an autoimmune and chronic musculoskeletal disorder that is associated with psoriasis of the skin . Its presentation can vary from subtle manifestations to highly destructive forms. Joint pain, stiffness and swelling are the most common symptoms. |
MARWA NAGUIB AHMED; | 2025-03-05 |
| 88 | The Relationship of Hand Sensory and Strength Assessments with Functionality and Kinesiophobia in Individuals with Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid arthritis (RA) is a systemic inflammatory disease that can involve all tissues with synovium. The wrist and hand, which are of great importance in our daily activities, are involved early and specifically because they are rich in synovium, which is the target tissue in RA.In many patients with rheumatoid arthritis, hand and wrist involvement is seen from the early stages of the disease. Pain, … |
FIRAT UNIVERSITY | 2025-03-05 |
| 89 | Anticholinergic Drug Use in Patients With Rheumatoid Arthritis and Its Effects on Fracture Risk PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory rheumatological disease. Use of corticosteroids for more than 3 months in RA treatment is considered an important risk factor in terms of developing secondary osteoporosis and increasing the risk of fracture. The cumulative effect of taking one or more drugs with anticholinergic properties is called anticholinergic load. It is stated that anticholinergic load also increases the risk of fracture in individuals. The aim of this study is to investigate the effects of drugs used by patients with Rheumatoid Arthritis (RA) on anticholinergic load and fracture risk. The Fracture Risk Assessment Tool (FRAX) will be used to assess fracture risk in patients. Materials and methods: The study was planned as a prospective cohort study. The study will included 100 patients who were followed up as outpatients with rheumatoid arthritis diagnosis in the physical medicine and rehabilitation clinic between 2024-2025. Patients of both genders and over 18 years of age diagnosed with rheumatoid arthritis will be included in the study. Patients with systemic diseases or medications affecting bone metabolism and those with metallic materials in the hip or lumbar vertebrae affecting bone mineral density measurement will be excluded from the study. Demographic characteristics, systemic diseases, medications used, bone density measurement and blood test values of the patients will be recorded. Patients taking multiple medications with anticholinergic effects create an anticholinergic burden. The Anticholinergic Drug Scale, Anticholinergic Cognitive Burden Scale and Anticholinergic Risk Scale will be used to measure anticholinergic burden in the study. |
BILAL UYSAL; | 2025-03-03 |
| 90 | Effect of Tight Urate Control in Gouty Arthritis Compared to Usual Care (TICOGA), A Randomised Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Gout is caused by a reaction to urate crystals that results in attacks of severe joint pain. Medicines that lower urate levels can prevent gout flares, however it takes time for this benefit to be felt, … |
PHILIP L RICHES; | 2025-03-03 |
| 91 | Effect of Hip Abductor Strengthening Exercises in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized controlled trial is to find the effect of hip abductor strengthening exercises on pain, range of motion, functional disability and balance in patient with knee osteoarthritis. |
KINZA ANWAR; | 2025-03-03 |
| 92 | Monocentric, Randomized Study, Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Some patients complain of articular noise (such as clicking, snapping, cracking or popping) after a total knee replacement. Controversy remains about whether there is a correlation between articular noise and worse outcomes following a knee replacement. A study by Nam et al. on 1540 patients revealed an association between noise and residual symptoms 30 days after they received a total knee replacement. Conversely, … |
ELSAN | 2025-03-01 |
| 93 | Advancing The Understanding of Pain Mechanisms in Inflammatory Arthritis Towards Precision Pain Management PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Our primary objective is to better understand the etiology and consequences of chronic paint by using an explorative approach to identify phenotypes and endotypes of patients with inflammatory arthritis, with a special focus on central sensitization and cognitive functioning as a key element in chronic pain. We will also examine the risk factors and clinical impact of these factors on pain, disease activity and treatment effects in a longitudinal study of patients with inflammatory joint disesases. |
IDA KRISTIN HAUGEN; | 2025-03-01 |
| 94 | Prevalence and Characteristics of Widespread Pain in People With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal is to evaluate whether the number of pain sites or pain estimation with Instant and Constant Osteoarthritis Pain (ICOAP) is related to functional impairment in the lower extremity in people with knee osteoarthritis (KOA). The main questions it aims to answer are: 1. What is the relationship between the number of pain sites and physical function when adjusted for age, sex, education level, and origin in people with KOA? 2. What is the relationship between pain experience measured with ICOAP (constant and intermittent pain subscales, as well as total score) and reduced physical function when adjusted for age, … |
CHAN-MEI HO-HENRIKSSON; | 2025-03-01 |
| 95 | A Prospective, Multicenter, Single-Blind, Randomized Controlled Clinical Trial of An Autologous Platelet-Rich Concentrated Growth Factor (CGF) Preparation Kit for The Treatment of Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effectiveness and safety of an autologous platelet-rich concentrated growth factor (CGF) preparation kit for the treatment of knee osteoarthritis in patients diagnosed with this condition. The main question it aims to answer is: Can the CGF preparation kit effectively improve symptoms and reduce pain in patients with knee osteoarthritis compared to a control intervention? Researchers will compare the CGF treatment group to a control group using platelet-rich plasma (PRP) to see if the CGF intervention results in greater improvements in knee function and pain relief. Participants will: Undergo three intra-articular injections of CGF or PRP into the knee joint at weekly intervals. Complete assessments including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS) for pain at specified intervals. Be monitored for safety and potential adverse events throughout the study period. |
GUANGDONG HONGZHI BIOTECHNOLOGY | 2025-03-01 |
| 96 | Investigation of Biopsychosocial Characteristics of Individuals Diagnosed with Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Since pain and depression are observed together in rheumatic diseases, the concept of limitation caused by the disease and health-related quality of life becomes more determinant than radiological joint damage. Sleep problems observed in OA also increase the level of depression findings and difficulty in movement. The chronic nature of the disease includes issues such as pain, fatigue, sleep problems, loss of function, anxiety, depression, and social isolation, together as in other chronic diseases. This complex structure accompanies a picture in which inflammatory processes are triggered. When the literature is examined, … |
AYSIMA BARLAK; | 2025-03-01 |
| 97 | Prophylactic Conjoint Tendon Lengthening During Reverse Shoulder Arthroplasty: Is There A Difference in Anterior Shoulder Pain At One Year After Surgery? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Some patients may experience persistent pain in the front of their shoulder after reverse shoulder replacement. One of the possible reasons for this is that the surgery causes a change in the alignment of the shoulder joint, which may cause increased tension and compression on one of the biceps tendon called the conjoint tendon. The purpose of this study is to evaluate whether conjoint tendon lengthening, a surgical procedure that involves cutting and lengthening the conjoint tendon in order to reduce tension and compression, … |
NICKOLAS GARBIS; | 2025-03-01 |
| 98 | Novel Perioperative Optimization of Obese Osteoarthritic Patients Pending Total Knee Replacement with Glucagon-like Peptide-1 Receptor Agonist (NPO-OOPS-TKR) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Studies have shown that obese patients undergoing total knee replacement (TKR) surgery face a higher risk of perioperative issues such as increased use of pain medication, surgical site infections, and the need for revision surgeries compared to non-obese patients. Obesity is also linked to more significant preoperative pain and lingering symptoms post-surgery. Consequently, … |
LAWRENCE LAU; | 2025-03-01 |
| 99 | Extracorporeal Shock Wave Therapy in Patients With Knee Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pathological arthritis is a degenerative disease affecting the joints, characterized by pain, limitation of movement up to ankylosis and disability. Treatment is aimed at reducing pain and slowing the loss of functionality of the district. Among conservative treatments, pharmacological options (NSAIDs, cortisone, contrasupplements, hyaluronic acid) and non-pharmacological options (therapeutic exercise, physical therapy, orthosis, etc.) are indicated. In cases not responding to conservative treatments, surgical treatment will be necessary with prosthetic replacement of the joint district. |
AZIENDA OSPEDALIERO UNIVERSITARIA CONSORZIALE POLICLINICO DI BARI | 2025-03-01 |
| 100 | Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Double-Blind, Pilot Randomized Sham-Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Genicular Artery Embolization for Reducing Pain in Symptomatic Knee Osteoarthritis: A Double-Blind, Pilot Randomized Sham-Controlled Study (SHAM-PAIN) is a NIH-NIAMS funded project designed to assess enrollment feasibility and detect any differences between GAE and a similar sham intervention in reducing KOA-related pain at 3 months as measured by the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscore. Additionally, this study aims to determine the magnitude of difference in pain response between GAE and sham to adequately power a larger, more definitive randomized sham-controlled trial (RCT). The influence of psychosocial and psychocognitive factors, changes in analgesic use, … |
OSMAN AHMED; | 2025-03-01 |
| 101 | Post-market Clinical Follow-up Study to Provide Safety, Performance and Clinical Benefits Data of The Comprehensive® Primary Revision Stems (Implants and Instrumentation) – A Retrospective and Prospective Consecutive Series Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this retrospective and prospective consecutive series PMCF (Post Market Clinical Follow Up) study is to collect long-term data confirming safety, performance and clinical benefits of the Comprehensive Primary Revision Stems (implants and instrumentation) when used for shoulder arthroplasty at 1, 3, 5, 7 and 10 years. |
ZIMMER BIOMET | 2025-03-01 |
| 102 | Comparative Outcomes of Robotic-Assisted Total Knee Arthroplasty: Cruciate-Retaining (CR) Versus Bi-Cruciate Retaining (BCR) in A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The global prevalence of osteoarthritis of the knee with total knee arthroplasty performed is projected to substantially rise in the near future. This phenomenon is also observed in Hong Kong in which more than 4000 elective total joint replacement surgeries were performed in 2021 and over 30,000 patients are on the waiting list where some regions would have to wait for a median of more than 4 years. REAL INTELLIGENCE™ CORI™ (CORI Navigation) is a computer-assisted orthopedic surgical navigation and blurring system. CORI Navigation is designed to aid surgeons in planning and executing a procedure involving bone preparation for total knee arthroplasty (TKA) procedures. CORI Navigation is comprised of a console control unit, optical tracking camera, primary and secondary input displays (tablet and optional display monitor), and foot pedal. The CORI Navigation software consists of a patient and user management module, a surgical planner, and an intra-operative cutting module. Bi-Cruciate Retaining (BCR) total knee arthroplasty (TKA) was designed for more kinematically functional implants that better reconstruct natural knee kinematics for activities of daily living. Surgical implant designs that resect the cruciate ligaments has emerged to simplify implantation and reduce surgical difficulty. The improvement of the biomechanical properties mimicking the natural kinematics of both the BCR and CR TKA may provide an effective solution to patient’s dissatisfaction and impaired functional outcomes after surgery. |
TIM-YUN MICHAEL ONG; | 2025-03-01 |
| 103 | MAintAin Activity in Arthritis: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Best practice guidelines across the world always recommend those living with arthritis to be physically active. Research shows that being active can help people living with arthritis to do the things that they want to do for longer, reduce pain, improve quality of life and protect against getting other health conditions such as heart disease, … |
ROYAL COLLEGE OF SURGEONS IRELAND | 2025-03-01 |
| 104 | Comparison of Functional Recovery Between Restricted Inverse Kinematic Alignment and Adjusted Mechanical Alignment with Robotic-assisted Unilateral Total Knee Arthroplasty. A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if restricted inverse kinematic alignment total knee arthroplasty (restricted iKA TKA) improves functional recovery compared to adjusted mechanical alignment total knee arthroplasty (aMA TKA) in patients undergoing unilateral robotic-assisted total knee arthroplasty by comparing performance-based outcome, 2-minute walk test (2MWT) as a primary outcome. This trial will also assess other outcomes including satisfaction, patient-reported functional outcomes, range of motion, visual analog scale for pain and complication of both techniques. The main question aims to answer is: In unilateral robotic-assisted total knee arthroplasty, … |
KRIT BOONTANAPIBUL; | 2025-03-01 |
| 105 | Pilot Investigation on The Effects of Sub Acute (12 Week) Home Base Whole-body Vibration Training in Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this proposal is to understand how the Vibrant Health Ultimate whole-body vibration (WBV) machine affects pain and inflammation in older adults. The investigators’ hypothesize that sub-acute (12 weeks) WBV will lead to improvement in the level of knee pain and improve vascular function via a decrease in systemic inflammation. |
AUGUSTA UNIVERSITY | 2025-03-01 |
| 106 | A Multicenter, Randomized, Double-blind, Controlled Phase III Trial of Allogenic Adipose Tissue-Derived Mesenchymal Stem Cells (AlloJoin®) Therapy for Knee Osteoarthritis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the efficacy and safety of Allogenic Adipose Tissue-Derived Mesenchymal Stem Cells Therapy |
WUXI CELLULAR BIOPHARMACEUTICAL GROUP | 2025-02-28 |
| 107 | A Phase 2, Two-Part, Randomized, Double-Blind, Active-Controlled Study to Assess The Safety and Tolerability of Enekinragene Inzadenovec (PCRX-201) in Subjects With Painful Osteoarthritis of The Knee PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if a single knee injection of different doses (Dose A and Dose B) of an investigation product PCRX-201, following steroid pretreatment, … |
BRADLY GOODMAN; | 2025-02-26 |
| 108 | NUTRA- Nutrition in Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Individuals with Rheumatoid Arthritis (RA) often experience persistent symptoms such as pain and stiffness despite modern pharmacological treatments. They also have an increased risk of cardiovascular disease. Elevated risk factors for cardiovascular disease limit the options for symptom-relieving medications, making a reduction in these risk factors highly desirable. Diet has been shown to reduce several of these factors, but the scientific evidence for rheumatoid arthritis is limited, … |
VASTRA GOTALAND REGION | 2025-02-25 |
| 109 | Is Hydro Dissection Treatment More Successful With Ultrasonography or Fluoroscopy in The Management of Adhesive Capsulitis? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the differences in joint range of motion, Visual Analog Scale (VAS) scores, and the Shoulder Pain and Disability Index (SPADI) outcomes in patients with adhesive capsulitis (frozen shoulder) who undergo hydrodilatation therapy with either ultrasound (USG) or fluoroscopy guidance, in addition to a suprascapular nerve block. |
DAMLA YÜRÜK; | 2025-02-25 |
| 110 | Systemic Oral Glucocorticoids for The Treatment of Acute Osteoarthritis Pain in The Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to compare the analgesic effects (relief of pain) of glucocorticoids (steroids) and pain medication versus pain medication alone in adult patients presenting to the emergency department with joint pain due to osteoarthritis. Steroids are drugs that can reduce inflammation and are used commonly for many different medical conditions. In brief, … |
BRENT BECKER; | 2025-02-24 |
| 111 | The Efficacy of Transcutaneous Pulsed Radiofrequency Acupuncture for Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Efficacy of transcutaneous acupoint pulsed radiofrequency with rehabilitation for knee osteoarthritis. |
SHIN KONG WU HO SU MEMORIAL HOSPITAL | 2025-02-24 |
| 112 | A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating The Efficacy and Safety of JNJ-77242113 for The Treatment of Biologic-naïve Participants With Active Psoriatic Arthritis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA. |
JANSSEN RESEARCH & DEVELOPMENT | 2025-02-21 |
| 113 | A Randomized, Controlled, Prospective and Multicenter Clinical Investigation Evaluating The Safety and Performance of ABIO3419 in Treating Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is a chronic degenerative joint disease characterized macroscopically by progressive damage of articular cartilage, joint space narrowing, subchondral bone remodelling, joint marginal osteophyte formation and synovitis. It is also characterized by a decrease of the concentration and molecular weight of the hyaluronic acid in the synovial fluid which ultimately leads to poor viscoelastic properties of synovial fluid and induction of proinflammatory pathways. The intra-articular injection of viscosupplementation gel (mainly exogenous hyaluronic acid) represents one of the most used therapeutic strategies to treat osteoarthritis symptoms. Several studies on knee Osteoarthritis, … |
KRISTAPS KNOHENFELDS; | 2025-02-21 |
| 114 | The Effect of Adding Reflexology to Mulligan Mobilization for Patient With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: to investigate the effect of adding Reflexlogy to mulligan mobilization and the conventional treatment for patients with Osteoarthritis knees |
RANIA AHMED NASSAR; | 2025-02-20 |
| 115 | Validity and Reliability Study of The Turkish Version of The Early Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The symptoms of early osteoarthritis (OA) are quite similar to established knee OA, they differ, particularly in frequency, intensity, and severity. For this reason, in 2023, the International Symposium of intra-articular treatment (ISIAT) technical experts panel (TEP-technical experts panel) published for the first time a questionnaire designed to assess and monitor the follow-up and clinical progression of patients affected by early knee OA. Early management of knee OA is recommended by various guidelines because this approach may alter the course and clinical features of the disease, especially when considering disease-modifying agents that may delay disease progression. Therefore, … |
FATMA MERIH AKPINAR; | 2025-02-19 |
| 116 | A Randomized, Double-Blind, Multi-Center, Placebo-Controlled, Trial to Evaluate The Efficacy and Safety of Once Daily Diclofenac Gel AMZ001 in The Treatment of Pain and Symptoms of Knee Osteoarthritis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, 6-week trial of a formulation of AMZ001 once daily versus placebo once daily. |
AMZELL | 2025-02-18 |
| 117 | An Alternative Assessment in Patients with Rheumatoid Arthritis: Comparing Bicycle Ergometer and 6 Minute Step Test and Proving The Validity of The 6 Minute Step Test PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Although joint involvement is predominant, RA is a systemic disease that can affect many organs. RA is a disease that includes changes such as inflammation, joint pain, fatigue, increased risk of coronary and heart disease. In patients with RA, exercises should be planned for decreased muscle strength, endurance, aerobic capacity and affected normal joint movements. Aerobic exercise capacity should be measured for individualized exercise planning in rehabilitation. Bicycle ergometer, one of the aerobic capacity tests, has been used in rehabilitation for a long time. Although it is frequently used in rehabilitation, it has some disadvantages. Therefore, … |
HAVVAGÜL DOĞAN; | 2025-02-18 |
| 118 | The Effect of A Group Exercise Intervention on Balance in People With Knee Osteoarthritis: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators want to find out if a 12-week exercise program improves balance in people with knee osteoarthritis. This study will involve two visits to the School of Kinesiology at the University of the Fraser Valley (Chilliwack campus). Each visit will last approximately one hour. Participants will be asked to fill out questionnaires and complete a balance test. In between visits, … |
GILLIAN HATFIELD; | 2025-02-18 |
| 119 | Physical and Mental Health Intervention for Black Adults with Knee Osteoarthritis: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research study is to test the feasibility of a physical and mental health intervention (Positive Minds, Strong Joints or PMSJ) for Black adults with knee osteoarthritis (OA). |
DEEPAK KUMAR; | 2025-02-17 |
| 120 | Efficacy and Safety of Acupuncture in The Treatment of Osteoarthritis of The Knee: Study Protocol for A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main question of this study was to evaluate the efficacy and safety of acupuncture in the treatment of knee osteoarthritis (KOA) through a single-blind, randomized controlled trial divided into two groups. Patients in both groups received a total of 24 acupuncture treatments over an 8-week period. The differences in knee NRS score, WOMAC index, walking test, mental health assessment and other indicators between the acupuncture group and the sham acupuncture group before and after treatment were compared to provide high-quality evidence to support the effectiveness of acupuncture in treating KOA. |
WU ZENAN; | 2025-02-15 |
| 121 | Personalized Physical Activity Promotion in Osteoarthritis Patients Using A Smartphone-based Solution PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this project is to promote physical activity in patients with osteoarthritis. More specifically, this study aims to test the acceptability of an app to promote physical activity in the target population, and consequently the feasibility of such an approach. A mobile phone application – namely PIANISSIMO – will be developed specifically for this project. It aims to spread knowledge on the benefits of physical activity and collect data on how this knowledge can induce behavior changes toward a more physically active lifestyle. The intervention is delivered via the app, … |
LAURENT MALISOUX; | 2025-02-13 |
| 122 | Evaluation of The MISHA® Knee System for Symptom Relief in Subjects With Medial Knee Osteoarthritis Versus The Use of Non-surgical Treatment: Randomized Clinical Trial and Comparison of Therapies for Medial Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with non-surgical treatment. This is the first randomized head-to-head study comparing outcomes from subjects treated with the MISHA Knee System. |
TIANYI WANG; | 2025-02-13 |
| 123 | Chinese Rheumatism Biobank(CRB) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Early prediction of major organ damage in SLE needs to dynamically track the evolution of SLE patients before and after the onset of major organ damage, and analyze the microscopic molecular evolution patterns synchronized with the macroscopic pathophysiological changes. |
CHINESE SLE TREATMENT AND RESEARCH GROUP | 2025-02-10 |
| 124 | Efficacy of NSAID Peritendinous Injection for Acute Tendinitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates whether NSAID peritendinous or ligament injections at acute sprain sites can relieve pain and restore function. Forty patients will be randomly assigned to either the injection or oral NSAID group. Pain will be assessed subjectively using the Numeric Pain Rating Scale and objectively through pressure pain threshold measurements. Functional outcomes (DASH for the upper limb, FADI for the lower limb) will be evaluated before treatment and at 3 days, 1 week, and 4 weeks post-treatment. |
YU-HSUAN CHENG; | 2025-02-10 |
| 125 | A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Crossover Multicenter Study to Explore The Safety and Efficacy of Oral PIPE-791 As Treatment in Subjects with Chronic Osteoarthritis Pain (COAP) or Chronic Low Back Pain (CLBP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of this clinical trial is to learn if PIPE-791 is safe and well-tolerated in adults with chronic osteoarthritis pain (COAP) or chronic low back pain (CLBP). The study will also explore whether PIPE-791 lowers pain in people with COAP or CLBP. Subjects will: * Complete a washout period to stop their current pain medications. * Take a daily dose of PIPE-791 or placebo for 4 weeks, … |
CONTINEUM THERAPEUTICS | 2025-02-04 |
| 126 | Web-based Rehabilitation After Surgical Salvage Procedures for Wrist Osteoarthritis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Wrist osteoarthritis is often caused by past trauma to the wrist. The primary symptom is joint pain. Salvage surgery is the final solution if exercise therapy, analgesics, orthoses, or cortisone injections fail to relieve pain. This trial aims to evaluate if a web-based rehabilitation protocol is non-inferior to standard, face-to-face, rehabilitation in terms of patient-reported outcome after surgical salvage procedures. |
ELIN SWÄRD; | 2025-02-03 |
| 127 | A Randomized Controlled Trial of Oral Curcumin for The Treatment of Pain of CMC Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the use of turmeric (Curcumin) as a treatment for pain of thumb-joint arthritis. Turmeric is commonly being used as an over-the-counter treatment for musculoskeletal pain. Clinical trials have demonstrated a pain-relief benefit for knee osteoarthritis, … |
BRENT DEGEORGE; | 2025-02-01 |
| 128 | Effectiveness of Therapeutic Exercises on Spinopelvic Mobility PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the extent to which spinopelvic exercises may affect either sagittal spinal deformity or spinopelvic mobility and identifying patients at risk for hip instability following a total hip replacement. |
JASON JENNINGS; | 2025-02-01 |
| 129 | Reducing Disparities in Hypertension Care for Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid arthritis (RA) is a autoimmune disease associated with an increased risk of developing coronary artery disease (CAD) and premature death, particularly in Black patients. Traditional CAD risk factors like hypertension (HTN) are both very common and poorly controlled among Black RA patients. Disparities in RA disease activity further increase the risk of CAD in this population. Black patients face significant barriers when seeking RA care, … |
DUKE UNIVERSITY | 2025-02-01 |
| 130 | Comparison of The Effectiveness of Conventional and Cooled Radiofrequency Ablation in Advanced Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to examine and compare the effects of conventional and cooled radiofrequency ablation on pain and disability levels in patients with knee pain resistant to other treatments due to knee osteoarthritis. |
AYSE NAZ KALEM; | 2025-02-01 |
| 131 | Estimating VO2 Max and Recovery in Patients Undergoing Total Hip Arthroplasty: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to estimate VO2 max levels at pre- and post-operative timepoints before and after hip arthroplasty surgery, using non-exercise-based measurement methods. |
TOM WAINWRIGHT; | 2025-02-01 |
| 132 | Prospective Multi-country, Real-world, Multi-arm Study of Treatment PErsistence With RISankizumab in Psoriatic Arthritis (PERIS) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriatic arthritis (PsA) is a type of arthritis (swelling and stiffness in the joints) that is frequently seen in trial participants who also have the skin condition psoriasis. It is caused by an overactive immune system where the body attacks healthy tissue by mistake. This study aims to describe the long term usage and effectiveness with risankizumab (RZB) relative to other advanced therapeutic options for the management of PsA in daily clinical practice. Risankizumab is an approved drug for the treatment of psoriatic arthritis. The study will not be conducted in the United States, … |
ABBVIE | 2025-01-31 |
| 133 | Evaluation of The Safety of LipiodolⓇ Embolization in Symptomatic Digital Osteoarthritis Refractory to Conventional Treatment: A Pilot Study of 15 Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the safety of arterial embolization using Lipiodol® in patients with symptomatic hand osteoarthritis refractory to conventional treatment. It will also learn about the efficacy of arterial embolization with Lipiodol® in reducing pain and improving hand function. The main questions it aims to answer are: * What are the side effects and complications associated with the Lipiodol® arterial embolization procedure? * Does arterial embolization reduce pain intensity and improve hand function? Researchers will evaluate patients over a 6-month period to assess the safety of Lipiodol® embolization and its impact on joint pain, … |
XAVIER ROMAND; | 2025-01-30 |
| 134 | The Effects of Patient and Visit Characteristics on Health Outcomes in Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to understand the patient and clinic visit characteristics that affect health outcomes for individuals with knee osteoarthritis (OA) pain using topical diclofenac gel. The main questions it aims to answer are: * What baseline patient characteristics predict response to topical diclofenac? * Does patient physiology during the study visit predict response to topical diclofenac? * Do study visit characteristics predict response to topical diclofenac? Participants will: * attend 2 study visits to complete study questionnaires and have blood drawn * apply topical diclofenac to their knee for 8 weeks * complete biweekly questions about knee pain and diclofenac use between study visits |
MICHELLE DOSSETT; | 2025-01-29 |
| 135 | A Double-blind, Placebo-controlled, Randomized Study to Evaluate The Efficacy and Safety of KBP-336 As An Adjunct to Diet and Exercise in Obese Individuals with Osteoarthritis of The Knee PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if KBP-336 works to treat pain in osteoarthritis in individuals living with obesity. It will also learn about the effects on other parameters, such as quality of life and metabolism, … |
KEYBIOSCIENCE AG | 2025-01-28 |
| 136 | Efficacy and Safety Study for The Combination of Etoricoxib / Betamethasone Compared to Etoricoxib for The Treatment of Patients Diagnosed With Acute Gout Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase III longitudinal, multicenter, randomized, double-blind clinical trial. The aim of this study is to evaluate the efficacy and safety of the Fixed-Dose Combination of Etoricoxib/Betamethasone Versus Etoricoxib in Patients With Acute Gouty Arthritis |
RAFAEL LANUZA-RAMIREZ; | 2025-01-27 |
| 137 | Validity and Reliability of The Six-minute Peg Board and Ring Test in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to evaluate the validity and reliability of 6-PBRT in patients with rheumatoid arthritis and to determine the applicability of the test for this population. |
BAŞAK KAVALCI KOL; | 2025-01-26 |
| 138 | Investigation of Respiratory Muscle Strength, Respiratory Muscle Endurance and Muscle Oxygenation in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate respiratory muscle strength, respiratory muscle endurance, muscle oxygenation, upper extremity and lower extremity exercise capacity in rheumatoid arthritis patients compared with healthy individuals. |
BAŞAK KAVALCI KOL; | 2025-01-25 |
| 139 | Investigation of Upper Extremity Exercise Capacity, Hand Grip Strength and Daily Living Activities in Rheumatoid Arthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There are limited studies in the literature evaluating upper extremity functional exercise capacity, muscle functions and daily living activities in rheumatoid arthritis patients. In this context, the aim of this study was to investigate upper extremity exercise capacity, hand grip strength and daily living activities in rheumatoid arthritis patients. |
BAŞAK KAVALCI KOL; | 2025-01-25 |
| 140 | COSTI: COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty – A Triple Blinded, Randomized Controlled Trial Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA. |
AMIR KHOSHBIN; | 2025-01-24 |
| 141 | A Multicenter, Prospective, Study to Evaluate The Impact of Modifying The Validated Psoriasis Epidemiology Screening Tool (PEST) on The Potential Diagnosis of Psoriatic Arthritis in Adult Patients With Moderate-to-severe Plaque Psoriasis in Canada (ScreenX) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the impact of adding two questions and pictures to the validated PEST on the potential diagnosis of PsA in participants with moderate-to-severe plaque PsO in Canada. |
NOVARTIS PHARMACEUTICALS | 2025-01-23 |
| 142 | Comparative Efficacy of Intra-articular Vs. MRI-guided Extra-articular Dextrose Injections in Knee Osteoarthritis Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is a serious worldwide public health concern, causing increased disability-adjusted life years (DALY), the reasons of which include rising prevalence of obesity and increasing older populations. The knee is one of the most easily injured joint in the body, and knee OA can become a chronic and disabling condition that pose a threat to not only the patient but also his or her caretakers and healthcare resources. The prevalence of knee OA is 5% – 15% in men over 60 years, and 10% – 25% in women aged more than 60. Knee OA can result from injuries, diseases, … |
LIN-FEN HSIEH; | 2025-01-23 |
| 143 | Effects of Including Interferential Current in A Therapeutic Exercise Program in Individuals With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The first-line treatment for knee osteoarthritis (KOA) in terms of pain and functionality is physical exercise. The use of interferential current (IC) associated with other resources may be beneficial in reducing pain intensity and improving functionality. However, the effects of its simultaneous use with therapeutic exercise have not yet been fully established. The aim of this project will be to evaluate the effects of including IC in a therapeutic exercise program in relation to pain intensity, functionality, self-efficacy, maximum voluntary contraction and overall perceived effect in individuals with KOA. Therefore, research participants of both sexes, … |
CID A GOMES; | 2025-01-20 |
| 144 | Genicular Artery Embolization for The Treatment of Moderate to Severe Osteoarthritic Knee Pain Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this investigation is to evaluate the safety of the geniculate artery embolization (GAE) procedure with HydroPearl® Microspheres in 30 patients with knee pain caused by osteoarthritis with 24 months follow-up. The GAE procedure is an arterial embolization procedure that blocks abnormal blood vessels caused be knee arthritis in order to evaluate the effect on knee pain. |
ANDREW PICEL; | 2025-01-15 |
| 145 | A Phase 2b, Multicenter, Double-blind, Placebo-controlled Randomized Withdrawal Study to Assess The Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat, ACPA-Positive Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase 2b, multicenter, double-blind, placebo-controlled, randomized withdrawal study is designed to assess the efficacy and safety of IMVT-1402 in adult participants with active, difficult-to-treat, anti-citrullinated protein autoantibody (ACPA) positive rheumatoid arthritis (RA). The primary objective is to evaluate the effects of IMVT-1402 compared to placebo, as measured by the American College of Rheumatology 20% (ACR20) response. |
IMMUNOVANT SCIENCES | 2025-01-10 |
| 146 | A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating The Efficacy and Safety of JNJ-77242113 for The Treatment of Biologic-experienced Participants With Active Psoriatic Arthritis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in biologic-experienced participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA. |
JANSSEN RESEARCH & DEVELOPMENT | 2025-01-09 |
| 147 | A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Phase 3 Study to Evaluate The Efficacy and Safety of Subcutaneous CT-P13 in Patients With Moderately to Severely Active Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Phase 3 Study to Evaluate the Efficacy and Safety of Subcutaneous CT-P13 in Patients with Moderately to Severely Active Rheumatoid Arthritis |
CELLTRION | 2025-01-03 |
| 148 | Effects of Feldenkrais Exercises on Pain, Range of Motion, and Disability in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to determine the effects of Feldenkrais Exercises on Pain, Range of Motion, and Disability in Patients with Knee osteoarthritis. Knee osteoarthritis poses significant challenges in pain management, mobility improvement, and disability reduction among middle-aged to older adults. Feldenkrais Method offers benefits comparable to back school lessons or core stability exercises. This study, conducted as a Randomized Controlled Trial at RIPHAH Rehabilitation Clinic, aims to assess the efficacy of Feldenkrais exercises compared to conventional physical therapy in addressing pain, range of motion, … |
GHULAM FATIMA; | 2025-01-02 |
| 149 | The Effect of ColcHicine on The Incidence of Knee or Hip Replacements: A Randomized, Double-blind, Multicentre Study in Symptomatic Knee or Hip Osteoarthritis PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effect of treatment with colchicine 0.5mg once daily as compared to placebo in patients with knee or hip osteoarthritis on the incidence of first occurrence of knee or hip replacement. The main question it aims to answer is: Does colchicine lower the number of knee or hip replacements in participants with osteoarthritis? Researchers will compare colchicine to a placebo (a look-alike substance that contains no drug) to see if colchicine works to treat osteoarthritis. Participants will: * take colchicine every day for 3 tot 4.5 years * visit the clinic every year for check-up and tests such as blood samples and x-rays * fill in questionnaires every 3 months |
SINT MAARTENSKLINIEK | 2025-01-01 |
| 150 | Correlation Between Radiculopathy And Quality Of Life In Patients With Chronic Lumbar Spondylosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to answer the following question: Is there a Correlation Between Lumbar Radiculopathy and Quality of Life in Patients with chronic lumbar spondylosis? |
MONA ABDELMAGEED ALI; | 2024-12-20 |
| 151 | Is Telerehabilitation A Good Alternative to Face-to-Face Rehabilitation Beyond Clinical Walls in Recovery After Total Hip Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if telerehabilitation in patients who had undergone total hip arthroplasty. The main questions it aims to answer are: – Does telerehabilitation improve the functional level of the participants? – Does telerehabilitation improve the locomotor performance of the participants? Researchers will compare telerehabilitation to face to face rehabilitation (traditional rehabilitation programme) to see if telerehabilitation works in total hip arthroplasty recovery. Participants will: – Attend physiotherapy and rehabilitation sessions supervised by a physiotherapist 2 days a week for 8 weeks. – … |
AKIN SÜZER; | 2024-12-15 |
| 152 | Phase 1b Randomized, Double Blind, Placebo-controlled Study to Evaluate Safety, Tolerability and Pharmacokinetics of LPX-TI641 in Patients With Rheumatoid Arthritis and Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to study the drug LPX-TI641 in patients with rheumatoid arthritis and psoriatic arthritis. We will compare the safety and tolerability of LPX-TI641 to placebo( a look-alike solution) that contains no drug). We will also evaluate the plasma pharmacokinetics of LPX-TI641. LPX-TI641 (or placebo) will be administered as an oral solution for 28 days. |
LAPIX THERAPEUTICS | 2024-12-15 |
| 153 | Evaluation of The Efficacy and Tolerability of An Exclusion Diet in Patients With Juvenile Idiopathic Arthritis: Interventional, Exploratory Single-center, Randomized, Controlled, Open-label, Add-on Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The JIA-ED study is a pilot project. Based on experience in another inflammatory disease, a 4-week period was extrapolated as sufficient to assess the effectiveness of the experimental intervention. This observation is supported by literature data showing that, halfway through phase I of the CDED (Crohn Diseasse Exclusion Diet), it is already possible to identify a subset of patients with Crohn’s disease who are responsive to the dietary treatment and who also have a higher likelihood of achieving clinical remission by the end of the first phase of the diet itself. |
PAOLO LIONETTI; | 2024-12-12 |
| 154 | An Analysis of Factors Associated with Chronic Musculoskeletal Pain, Pain Management Preferences, Coping Strategies and Health-related Quality of Life Among Older People: A Comparative Cross-Cultural Study of Turkey, Croatia and Romania PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic musculoskeletal pain is common among older adults. This study aimed to identify and describe the characteristics of chronic musculoskeletal pain, pain management and coping strategies among older adults from Turkey, Croatia and Romania. The study also aimed to explore cultural differences in pain experience and management. Methods: 337 older adults with chronic pain participate 100 from Turkey, 131 from Croatia and 106 from Romania. Semi-structured interviews will explore four main topics, including factors influencing pain, coping strategies, management strategies, and health-related quality of life. |
EYLÜL PINAR KISA; | 2024-12-10 |
| 155 | Ultrasonographic Measurement of Thumb Muscle Thickness and Evaluation of Pinch and Grip Strength in First Carpometacarpal Joint Osteoarthritis: A Comparison of Early and Advanced Stages PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A total of 34 patients aged between 50-80 years, diagnosed with first carpometacarpal joint osteoarthritis based on hand radiographs taken within the last 3 months, will be included in the study from the Physical Therapy and Rehabilitation outpatient clinic. Sociodemographic data such as age, gender, height, weight, and BMI will be recorded. Based on their current radiographs, patients will be classified into two groups according to the Eaton-Littler classification: Stage 1-2 (early stage) and Stage 3-4 (advanced stage). Pain levels will be assessed using the Visual Analog Scale (VAS). Hand grip strength will be evaluated with a Jamar hand dynamometer, … |
BUSRA SIRIN; | 2024-12-10 |
| 156 | Clinical Study Evaluating Anti Rheumatic Activity and The Role of Silymarin in Attenuating Methotrexate Toxicity in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the anti-rheumatic activity and the role of silymarin in attenuating methotrexate toxicity in patients with rheumatoid arthritis. Methodology: This is a randomized, double blind placebo controlled parallel study that will be conducted on 44 patients with active rheumatoid arthritis. Group1 (placebo group; n=22) which will receive IM or SC Methotrexate plus placebo tablet once daily for 3 months. Group2 (Silymarin group; … |
HEND MOHSEN MOHAMED EL-METWALLY; | 2024-12-10 |
| 157 | Effects of Thoracic Mobility Exercises on Thoracic Hyper Kyphosis and Impact on Hamstring Flexibility in Patients With Tibio Femoral Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized clinical trial is to find the effect of thoracic mobility exercises on thoracic hyper kyphosis and hamstring flexibility with tibiofemoral arthritis patients on reducing hyper kyphotic posture, knee pain and improving flexibility of hamstring muscles. |
MARIA KHALID; | 2024-12-03 |
| 158 | Effect of Manual Diaphragmatic Release on Ventilatory Functions in Women With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the effect of manual diaphragmatic release on ventilatory functions in women with rheumatoid arthritis |
SAHER LOTFY EL GAYAR; | 2024-12-03 |
| 159 | IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients and Its Relation With Response to Systemic Biologic Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. It impairs patients’ quality of life enormously. Psoriasis refers to a persistent inflammatory illness of the skin and joints. It also impacts roughly 2%-3% of the inhabitants of the universe |
FATMA ABDEL-MONEM MAHMOUD; | 2024-12-01 |
| 160 | Epidemiology of Gonococcal Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this retrospective observational study was to describe the epidemiology of Neisseria gonorrhoeae septic arthritis over the last 10 years at Brest and Rennes university hospitals. The main question is whether there are any risk factors based on the epidemiological and clinical data on these cases. The second objective is to characterize the gonococcal strains isolated in order to determine whether there is a common clone, a virulence factor or specific resistance genes. |
GENEVIÈVE HERY-ARNAUD; | 2024-12-01 |
| 161 | The Effect of Spinopelvic Movements on Hip Functions in Patients With Total Hip Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study aims to evaluate the effect of spinopelvic movement on hip functions in individuals who have undergone total hip arthroplasty (THA). This study will contribute to the literature by helping identify and prevent issues experienced by THA patients, ranging from hip pain to limited mobility and even hip dislocation. |
ELIF AYGUN POLAT; | 2024-12-01 |
| 162 | Generating Evidence Study for Systemic Lupus Erythematosus Using Different Types of Methodologies PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The project will be conducted in four distinct stages. Firstly, evidence synthesis will be carried out to gather and analyze available data on the topic. Following this, a discussion among physicians will be facilitated to understand the knowledge gaps among rheumatologists and other specialists regarding SLE. Subsequently, consensus will be sought among a select group of rheumatologists on various aspects related to patient care, unmet medical needs, and implementation of new technologies. Finally, the findings and conclusions from these stages will be used to inform the development and publication of scientific papers. |
ASTRAZENECA | 2024-11-30 |
| 163 | Assessment of The Reliability and Validity of The Six-Spot Step Test in Patients Following Total Hip Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the SSST’s validity, reliability, and ability to differentiate between high and low fall risk individuals in THA patients. Establishing the SSST as a valid and reliable tool will help manage rehabilitation and apply timely interventions for THA patients. |
ELIF AYGUN POLAT; | 2024-11-30 |
| 164 | SakuraBead Used As Resorbable Embolic for Genicular Artery Embolization PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An open label, prospective, two-arm, multicenter, randomized controlled trial comparing SakuraBead genicular artery embolization (GAE) with a control (corticosteroid injection). |
CRANNMED | 2024-11-28 |
| 165 | Effect of Chondractiv Move (Dietary Supplement) on Activity-related Joint Discomfort in Physically Active Subjects: A Double-blind, Randomized, Placebo-controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Joint discomfort, manifested as knee pain or gonalgia, is a common problem not only among athletes, but also among people who regularly take part in physical activities and sports. This discomfort can limit mobility and flexibility, even in healthy people who do not suffer from osteoarthritis or other joint diseases. Functional joint discomfort is also due to joint stress and the short-term deterioration of cartilage. The processes of cartilage formation and degradation lose their balance under load, … |
CAROLE PERRIN; | 2024-11-25 |
| 166 | Randomized, Sham Controlled, Single Blind Study on The Performance and Safety of Photo Biomodulation Therapy (PBMT) With LightForce® Therapy Lasers on Knee Osteoarthritis Pain Reduction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: DJO UK Ltd (ENOVIS) is conducting this study to assess the effectiveness of LightForce® Therapy Lasers on pain reduction in subjects with unilateral or bilateral knee osteoarthritis. In detail this study will assess superiority of LightForce® Therapy Lasers combined with standard of care, represented by physiotherapy/exercise program compared to sham laser combined with standard of care (physiotherapy/exercise program) on pain reduction in subjects with knee osteoarthritis. In addition, this study allows to collect post market clinical data on the safety and performance of LightForce® Therapy Lasers, when used, following the normal clinical practice, … |
BERNARD BONTHOUX; | 2024-11-23 |
| 167 | Effect of Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA): A Randomized, Double-Blind, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a trial of tirzepatide in people with obesity and knee osteoarthritis. The main purpose of this study is to see if tirzepatide can reduce number of these participants who require a knee replacement. Participants will be randomized to take a weekly injection of tirzepatide or a placebo for a total of 72 weeks. |
MICHELLE M DOWSEY; | 2024-11-19 |
| 168 | Assessment of Cardiorespiratory Fitness Using The Progressive Aerobic Cardiovascular Endurance Run in Patients with Juvenile Idiopathic Arthritis and Familial Mediterranean Fever: A Healthy Control Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Juvenile Idiopathic Arthritis (JIA) and Familial Mediterranean Fever (FMF) are the most common autoimmune and autoinflammatory rheumatic diseases in childhood. Symptoms such as reduced muscle strength, joint pain, fatigue, and limited activity, which are common in childhood rheumatic diseases, often lead to impaired physical function. Cardiorespiratory fitness, which is an important indicator of physical function, plays a critical role in health-related outcomes in children and adolescents with rheumatic disease. Maximum oxygen consumption (VO2 peak) is considered the fundamental criterion for evaluating cardiorespiratory fitness. The need for extensive equipment and trained personnel, … |
ASYA ALBAYRAK; | 2024-11-11 |
| 169 | Placebo Response of Different Types of Sham Acupuncture for Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to conduct a randomized controlled trial to investigate the difference in clinical efficacy and blinding effect between real acupuncture and various sham acupuncture techniques. |
SUN XIN; | 2024-11-10 |
| 170 | A Randomized, Placebo-controlled, Multicenter, Study to Evaluate The Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis (UP-SPOUT) PF:3 Related Papers Related Patents Related Grants Related Experts View |
WALTER MAKSYMOWYCH; | 2024-11-06 |
| 171 | Evaluation of The Treatment of Arthritis and The Correction of Bone Alignment Default of The Toes Using The Lync® Medical Device PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The LYNC clinical investigation aims to confirm the clinical benefits, performance and safety of the Lync® device when implanted in the toes for the treatment of arthritis and correction of bone misalignments. The main objective of the study is to confirm the clinical benefits of the Lync® device for the treatment of arthritis and the correction of bone alignment default, by evaluating the restoration of the functional capacities of the forefoot at 3 -4 months post-operative follow-up with AOFAS-LMIS score. |
NOVASTEP | 2024-11-04 |
| 172 | Comparison of The Effectiveness of Autologous Conditioned Serum and Platelet-rich Plasma in Temporomandibular Joint Osteoarthritis; A Randomized Prospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Temporomandibular joint (TMJ) disorders are health conditions that can occur at any age and are recognized as the most common cause of chronic pain, affecting 5-12% of the population. Pain in the TMJ region can lead to limitations in mouth opening and lateral movements of the mandible. In cases where conservative treatments are insufficient for TMJ disorders and osteoarthritis, symptoms can be alleviated through arthrocentesis, a minimally invasive procedure with a low risk of complications, … |
ROJDAN FERMAN GÜNEŞ UYSAL; | 2024-11-01 |
| 173 | A Phase 3, Multicenter, Open-label, Basket, LTE Study to Evaluate The Safety of Guselkumab in Pediatric Participants With Crohn’s Disease, Ulcerative Colitis, or Juvenile Psoriatic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate long-term safety of subcutaneous guselkumab in pediatric participants with moderately to severely active ulcerative colitis, or moderately to severely active Crohn’s disease, or juvenile psoriatic arthritis (jPsA). |
JANSSEN RESEARCH & DEVELOPMENT | 2024-10-29 |
| 174 | Optimizing Treatment for Children and Adolescents with Juvenile Idiopathic Arthritis in Sustained Remission: A Comparison of Three Treatment Strategies. The MOVE-JIA Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare three different maintenance and step-down treatment strategies in children and adolescents with juvenile idiopathic arthritis in sustained remission. The main questions it aims to answer are: * Is the proportion of study participants with a disease flare different between each of the two drug withdrawal arms and the stable treatment arm during 12 months? * Does the proportion of study participants with a disease flare differ between the two drug withdrawal arms during 12 months? * How long time does it take before a disease flare occurs, … |
ANNA-BIRGITTE AGA; | 2024-10-24 |
| 175 | A Multicenter, Randomized, Double-Blind, Risankizumab-Controlled, Parallel-Group Study to Evaluate The Efficacy and Safety of Bimekizumab in Adult Study Participants With Active Psoriatic Arthritis PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to compare the efficacy of bimekizumab versus risankizumab after 16 weeks of treatment in study participants with active psoriatic arthritis (PsA). |
UCB BIOPHARMA SRL | 2024-10-21 |
| 176 | Feasibility of A Self-management App for People with Knee Osteoarthritis (OA-AID Feasibility Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this feasibility trial, an 8-week digital intervention including remote monitoring in patients with knee osteoarthritis (OA) will be tested. The app will provide information on osteoarthritis and recommended treatment for people with knee OA. |
ANNE THERESE TVETER; | 2024-10-20 |
| 177 | A Phase 3, Parallel-group, Randomized, Double-blind, 3-arm, Placebo-controlled, Multicenter Study to Investigate The Efficacy and Safety of Subcutaneous Sonelokimab in Male and Female Participants Aged 18 Years and Over With Active Psoriatic Arthritis Who Are Naive to Biologic DMARDs PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study to demonstrate the clinical efficacy and safety of sonelokimab administered subcutaneously compared with placebo in the treatment of adult patients with active psoriatic arthritis who are naive to biologic disease-modifying antirheumatic drug therapy. |
MOONLAKE IMMUNOTHERAPEUTICS AG | 2024-10-15 |
| 178 | Effect of Baduanjin on Pain, Balance and Kinesiophobia in Individuals With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is the most common rheumatologic disease in the world, primarily resulting in progressive cartilage destruction. It is most common in the knee joint. In this study, it is aimed to determine the effect of Baduanjin to reduce kinesiobia and increase functional exercise capacity by reducing or completely eliminating balance loss and pain in patients with knee osteoarthritis and to shed light on future studies. 60 individuals between 40 and 70 years of age with osteoarthritis will be included in the study. Individuals will be randomized into three groups. In the study, … |
ZEYNEP HOŞBAY; | 2024-10-15 |
| 179 | Clinical Study Evaluating The Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this clinical trial is to Evaluate the Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate. Methodology: This is a randomized, double blind placebo controlled parallel study that will be conducted on 44 patients with active rheumatoid arthritis. Group1 (placebo group; n=22) which will receive IM or SC Methotrexate plus placebo tablet once daily for 3 months. Group2 (Empa group; … |
NEHAD WALEED KARAM; | 2024-10-15 |
| 180 | SOFT KNEE BRACE VERSUS LATERAL WEDGE FOOT INSOLE on PAIN and PROPRIOCEPTION in KNEE OSTEOARTHRITIS PATIENTS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the aim of study is to investigate the efficacy of soft knee brace versus lateral wedge foot insole on pain and proprioception in knee OA |
OMAR HA ABDELMOAMEN EL SAYED; | 2024-10-15 |
| 181 | An Artificial Intelligence-based Approach in Total Knee Arthroplasty: from Inflammatory Responses to Personalized Medicine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Goal: The goal of this interventional study is to understand how multimodal preoperative data can predict outcomes after Total Knee Arthroplasty (TKA) and improve personalized medicine practices. Participant Population: The study will enroll 197 patients suffering from symptomatic, end-stage knee osteoarthritis, who are above 18 years old and have functionally intact ligaments. Main Questions: * Can multimodal preoperative data, genetic predisposition, and psycho-behavioral characteristics predict outcomes after TKA? * Can AI models effectively use this data to customize prostheses and surgical interventions, … |
UMILE GIUSEPPE LONGO; | 2024-10-14 |
| 182 | A Prospective, Randomized, Double-blind, Parallel-group Study to Compare The Efficacy, Safety, Pharmacokinetics and Immunogenicity of MB04 and EU-sourced Enbrel® in Patients with Moderate to Severe Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A study to compare efficacy, pharmacokinetics, safety and immunogenicity of MB04 \[proposed etanercept biosimilar\] to Enbrel® \[EU-sourced\] in rheumatoid arthritis |
MABXIENCE RESEARCH S L | 2024-10-03 |
| 183 | Causal Association Between Rheumatoid Arthritis and Periodontitis: A Mendelian Randomization Study PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population. |
ZHIBIN XU; | 2024-10-01 |
| 184 | Policy-Induced Conservative Management Prioritization Over Arthroplasty on Knee Osteoarthritis Outcomes PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the long-term effects of a non-surgical management programme in people with osteoarthritis that are eligible for a knee joint replacement surgery to treat their knee osteoarthritis (KOA). The main question it aims to answer is: – Does the non-surgical management programme reduce the proportion of referred patients who are treated with a knee arthroplasty without reducing the health-related quality of life over a two-year perspective? |
MARIUS HENRIKSEN; | 2024-10-01 |
| 185 | Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the ability of long-duration low intensity therapeutic ultrasound (LITUS) to alleviate knee Osteoarthritis pain over a 24-week period. The primary objective of this study is to evaluate the analgesic effect of LITUS in subjects suffering from knee Osteoarthritis pain. Secondary objectives are to assess the ability of LITUS to improve joint function. |
GEORGE K LEWIS; | 2024-10-01 |
| 186 | The Relationship Between The Level of Somatosensory Amplification and Psychological and Functional Status in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As modern society enters the age of an aging population, the prevalence of knee OA continues to increase, which necessitates multi-faceted research. Although there are studies on exaggeration of bodily sensations, depression, kinesiophobia and functional status in patients with knee OA, there are deficiencies in correlating these factors with each other and in directing evaluation and treatment programs. Based on this, this study aims to demonstrate the relationship between the level of exaggeration of bodily sensations, psychological-functional status and perceived pain level in patients with knee pain due to knee OA. |
MESUT ERGAN; | 2024-10-01 |
| 187 | 30-Second Sit-to-Stand Test As An Alternative Tool for Assessing Functional Capacity in Patients With Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Juvenile Idiopathic Arthritis (JIA) is a heterogeneous, idiopathic, chronic inflammatory, rheumatic disease that is most common in childhood and is thought to involve immunological mechanisms in its etiopathogenesis. The physiology of children and adolescents is constantly changing due to the development and maturation of their systems. At the same time, the changes that this population shows, especially during the growth spurt and adolescence, can affect their performance in frequently used functional tests such as the 6-Minute Walk Test (6MWT). At the same time, … |
NILAY ARMAN; | 2024-09-30 |
| 188 | Evaluation of The Safety and Hemostatic Effectiveness of SURGICEL® Powder in TKA：a Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study subjects are patients in our hospital’s orthopedics department undergoing unilateral primary total knee arthroplasty (TKA) due to primary osteoarthritis. Through a prospective, parallel randomized controlled study, 112 participants will be divided into two groups: the SURGICEL® Powder group and the non-use group. The study will compare the total perioperative blood loss , intraoperative blood loss, transfusion rate and volume, postoperative hemoglobin decline, hematocrit decline, limb swelling rate , postoperative limb pain , and range of motion. Statistical analysis will be performed on the data to observe the hemostatic effects of SURGICEL® Powder, … |
PEKING UNIVERSITY THIRD HOSPITAL | 2024-09-28 |
| 189 | Efficacy and Safety of Ixekizumab or Ixekizumab Concomitantly Administered With Tirzepatide in Adult Participants With Active Psoriatic Arthritis and Obesity or Overweight: A Phase 3b, Randomized, Multicenter, Open-Label Study (TOGETHER-PsA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to demonstrate that when participants with psoriatic arthritis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in their psoriatic arthritis and achieve weight reduction compared to when receiving ixekizumab. Participation in this study includes up to 12 visits and could last up to 61 weeks including screening, open label treatment period, and post-treatment follow-up period. |
ELI LILLY | 2024-09-24 |
| 190 | Orthobiologic Treatment for Knee Osteoarthritis (Ortobiologisk Behandling Av Kneleddsartrose) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to compare treatment for osteoarthritis in the knee using platelet rich plasma (PRP) or adipose stem cells (ADS). The main questions it aims to answer are: * Will the patients clinically benefit from the treatment, and if so, which treatment is better? * Will there be radiological findings to support this? Participants will be randomized into one of four groups: PRP, ADS, PRP + ADS or placebo treatment (saline) and will be examined and get an X-ray and MRI of the knee taken at inclusion and after 1 and 2 years. |
UNIVERSITY HOSPITAL OF NORTH NORWAY | 2024-09-23 |
| 191 | Reducing The Burden of Post-traumatic Knee Osteoarthritis Targeting Persistent Abnormal Joint Loading and Quadriceps Muscle Dysfunctions in Young Adults with ACL Injury – A Pilot and Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: FROM RISK FACTORS TO THE PREVENTION OF LONG-TERM CONSEQUENCES AFTER CRUCIATE LIGAMENT INJURY (ACL injury) – This is a research project where we seek new knowledge about why some people have a high risk and others a low risk of developing long-term consequences such as persistent pain, thigh muscle dysfunctions and osteoarthritis after ACL surgery. Through more knowledge about risk factors for persistent pain, thigh muscle dysfunctions, and, in the long term, osteoarthritis, … |
MAY ARNA RISBERG; | 2024-09-19 |
| 192 | A Pilot Randomized-controlled Trial Evaluating The Efficacy of A Live-Online Mindfulness-Based Intervention: The Making Mindfulness Matter© in Children with Juvenile Idiopathic Arthritis Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigator will evaluate the efficacy of M3©, an intervention for patients with JIA and their caregivers. Children with Juvenile arthritis and their parents will attend an 8 week online program called Making Mindfulness Matter (M3). This is a facilitator-led program that integrates knowledge and skills related to mindfulness, social-emotional learning, neuroscience, and positive psychology to promote coping and resiliency for children and families in context of the challenges of pediatric chronic disease. The child program is designed for children 4-12 years of age, … |
ROBERTA BERARD; | 2024-09-12 |
| 193 | Efficacy and Safety Study of The Fixed-dose Combination of Celecoxib/Acetaminophen Compared to Celecoxib for The Treatment of Pain in Patients Diagnosed With Osteoarthritis in Acute Exacerbation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase III, longitudinal, multicenter, randomized, double-blind clinical trial designed to evaluate the efficacy and safety of a fixed-dose combination of celecoxib and acetaminophen compared to celecoxib monotherapy for the treatment of pain associated with acute exacerbations of osteoarthritis. |
ISABEL E RUCKER-JOERG; | 2024-09-09 |
| 194 | The Efficacy of A Complex Interdisciplinary Nurse-Coordinated SELf-MAnagement Intervention for People with Substantial Impact from Their Inflammatory Arthritis: Protocol for The Randomized Pragmatic INSELMA Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Patients with inflammatory arthritis (IA) experience substantial impact of their disease despite optimal pharmacological treatment. To be able to manage these challenges effectively, patients require tailored self-management support from various professionals. We thus developed a six-month nurse-coordinated interdisciplinary self-management intervention (INSELMA), in collaboration with patients, clinicians and managers. A pilot study on the INSELMA intervention in 18 participants showed promising results. It is now relevant to test the intervention and compare it to a control group in a larger study . Objectives: The primary objective is to compare the efficacy of the INSELMA intervention to usual care (control group), … |
JETTE PRIMDAHL; | 2024-09-05 |
| 195 | Association of Helicobacter Pylori Infection With Disease Activity in Systemic Lupus Erythrematosis and Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To find the relation of Helicobacter pylori with disease activity in SLE and RA |
FATMA MOSTAFA MOHAMED AHMED; | 2024-09-04 |
| 196 | Efficacy of Biodex Balance Training Versus Whole Body Vibration Training in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to answer the research question: Are there differences between the effect of Biodex balance training and Whole-body vibration training on Knee osteoarthritis? |
CAIRO UNIVERSITY | 2024-09-01 |
| 197 | Wrist and Carpal Arthrodeses. A 1-year Follow-up Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study at the Orthopedic Department, Drammen Hospital, examines the effectiveness and safety of various arthrodesis procedures in the wrist and carpus to relieve chronic pain and restore functional stability. Arthrodesis, which fuses two or more bones to eliminate joint mobility, is considered as a last resort when conservative treatments do not produce the desired results. The study includes patients with advanced degenerative changes, rheumatoid arthritis, or extensive injuries. Patients assessed preoperatively and postoperatively through measurements of range of motion, grip strength, and pain using various tools such as PRWHE, QuickDASH, … |
VESTRE VIKEN HOSPITAL TRUST | 2024-09-01 |
| 198 | Effect of CDMARD and Baricitinib Therapy on IL-6, IL-12, IL-15 and IL-23 Expression Levels in Rheumatoid Arthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation and articular damage. Continuous medical research has dramatically improved the outcomes for patients with RA. Traditional therapeutic approaches have relied on glucocorticoids, nonsteroidal anti-inflammatory drugs (NSAIDs) and disease modifying antirheumatic drugs (DMARDs) such as methotrexate, sulfasalazine or leflunomide. Glucocorticoids and NSAIDs interfere with the inflammatory cascades while DMARDs impede both the inflammatory and the destructive processes of RA. These drugs, although efficient, are not specifically directed against inflammatory cells or cytokines and are associated with significant toxicity. The development of biologic DMARDs (bDMARDs), … |
MAHA SAYED IBRAHIM ABDELRAHMAN; | 2024-09-01 |
| 199 | Is There A Relationship Between Ultrasound Findings of Thumb Muscles and Grip Strength in Addition to Pain Threshold in Thumb Carpometacarpal Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Carpometacarpal (CMC) joint osteoarthritis is a disorder that is estimated to affect more than one-third of postmenopausal women, leading to decreased muscle strength, reduced joint range of motion, and pain.The pathogenesis of thumb CMC osteoarthritis involves complex interactions between biomechanical forces, genetic predisposition, hormonal changes, repetitive microtrauma, and aging. An important factor in the progression of carpometacarpal osteoarthritis is the loss of joint stability provided by the surrounding muscles (2). The common methods for diagnosing thumb CMC OA is plain radiographs and clinical examinations. However, radiographs are unable to assess the role of surrounding structures, … |
FATIH SULTAN MEHMET TRAINING AND RESEARCH HOSPITAL | 2024-08-31 |
| 200 | A Multi-center, Open, Randomized, 18-month, Parallel-group, Superiority Study to Compare The Effect of Proactive Therapeutic Drug Monitoring Versus Standard of Care With Regards to Maintenance of Sustained Disease Control Without Flare in Adults With Rheumatoid Arthritis Treated With A Subcutaneous Tumor Necrosis Factor Inhibitor PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare therapeutic drug monitoring (TDM) versus Standard of care in patients with rheumatoid arthritis treated with a subcutaneous tumor necrosis factor inhibitor (adalimumab). The main question it aims to answer is: Is TDM superior to standard of care in order to maintain sustained disease control without flares? Participants will be followed with blood sampling every second month, measuring serum drug levels and anti-drug antibodies of the TNFi. In the TDM-group, the researchers will adjust the dosage of the TNFi based on knowledge on optimal therapeutic ranges. In the Standard of care group, … |
HELGA LECHNER-RADNER; | 2024-08-20 |
| 201 | Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation: A Randomized, Single-blind, Placebo-controlled Parallel-group Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research evaluated the effects of UCII, glucosamine and curcumin supplementation on knee pain and inflammation. |
TAIPEI MEDICAL UNIVERSITY | 2024-08-20 |
| 202 | Construct Validity and Responsiveness of EQ-5D-3L in Patients With Rheumatic Disease PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the construct validity (convergent and known-groups) and responsiveness of EQ-5D-3L in patients with rheumatoid arthritis, polyarthritis, psoriatic arthritis, and ankylosing spondylitis. The study is based on retrospective registry data from the Swedish Rheumatology Registry (SRQ). |
EMELIE HEINTZ; | 2024-08-16 |
| 203 | Evaluating The Physiological Impact of Pain Neuroscience Education Versus Standard Education for Older Adults With Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators are comparing two types of education for older adults with knee osteoarthritis: standard biomedical education focusing on the disease process, and a newer approach called pain neuroscience education (PNE), which teaches about the complexity of pain and dispels myths. While PNE has shown benefits in self-reported pain and function, little is known about its effects on physiological responses to pain. the investigators will measure physiological indicators, particularly activity in the autonomic nervous system (ANS), … |
LISA CARLESSO; | 2024-08-15 |
| 204 | Activating The Cholinergic Anti-Inflammatory Pathway with Focused Ultrasound Stimulation in Healthy Volunteers and People with Inflammatory Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to investigate whether non-invasive ultrasound (US) that is optimized for stimulation and can elicit an anti-inflammatory response in people with Inflammatory Arthritis as compared to a sham intervention. The primary endpoint is the change in pro-inflammatory cytokines in blood drawn before and after US. Each participant receives 4 experimental US sessions, one of which is randomly assigned to be placebo. |
SURF THERAPEUTICS | 2024-08-15 |
| 205 | The Relationship Between Serum Chemokine Ligand 21 (CCL-21) Level and Disease Activity in Patients With Rheumatoid Arthritis and Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid arthritis (RA) is a chronic systemic disease characterized by the development of new capillaries involved in the infiltration of inflammatory cells causing synovial hyperplasia and progressive destruction of cartilage and bone.Osteoarthritis (OA) is a degenerative joint disease that involves articular cartilage and other intra-articular structures.Although the pathological mechanisms involved in OA and RA are different, the onset and progression of both diseases are associated with inflammation, … |
GAZIOSMANPASA RESEARCH AND EDUCATION HOSPITAL | 2024-08-12 |
| 206 | Ultrasonographic Evaluation of Asymptomatic Shoulder Joint Pathologies in Rheumatoid Arthritis Patients Compared to Healthy Controls: Case-Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ultrasonographic determination of changes and degree of damage in asymptomatic shoulder joint periarticular structures in RA patients and comparison with healthy controls. |
YUNUS EMRE DOGAN; | 2024-08-12 |
| 207 | Early Photobiomodulation Therapy on Pain and Range of Motion Following Flexor Tendon Repair PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study was to evaluate the therapeutic effect of low-level laser in improving pain and ROM following flexor tendon repair surgery. |
REHAB HESHAM MOHAMED EL-SHEIKH; | 2024-08-01 |
| 208 | Effects of Platelet-Rich Plasma and Ozone Therapy on Pain and Quality of Life in Knee Osteoarthritis: A Retrospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered. In advanced-stage gonarthrosis, steroid injections may respond. However, in mild and moderate knee arthritis, regenerative methods come to the forefront because the joint cartilage is still partially/completely intact. PRP and ozone therapy are frequently applied intra-articular treatments. This study will compare the effects of both injection methods on clinical outcomes. |
SELDA ÇIFTCI; | 2024-08-01 |
| 209 | Biochemical Role of Matrix Metalloproteinase -9 in Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid arthritis (RA) is a systemic autoimmune pathology associated with a chronic inflammatory process, which can damage both joints and extra-articular organs, including the heart, kidney, lung, digestive system, eye, skin and nervous system.(Cojocaru et al. 2010, Conforti et al. 2021). Rheumatoid arthritis affects most commonly the hand, wrist, and foot, but it can also affect large joints .IT is characterized by painful, swollen joints that can severely impair physical function and quality of life and associated with increased mortality (Sparks et al. 2016). About 70% of patients with RA are women, … |
BASMA ABOELFOTOH MAHMOUD; | 2024-08-01 |
| 210 | Double-Blind Randomized Controlled Trial Comparing The Effectiveness of Two Standardized Radial Pressure Wave Techniques Versus Pain-Site Guided Therapy in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate and compare the effectiveness of radial pressure wave therapy (RPWT) applied at different anatomical sites in patients with knee osteoarthritis (OA) over a follow-up of four months. The main questions it aims to answer are: How effective is the application of RPWT on the medial and lateral interarticular lines in patients with knee OA? Are standardized RPWT application techniques on interarticular lines superior to the traditional application technique on the points of greatest pain in patients with knee OA? Researchers will compare the effectiveness of two standardized application techniques on interarticular lines to decrease pain and improve function in patients with knee OA. Participants will receive three sessions of RPWT on the most painful knee as a result of knee OA. |
ARMANDO TONATIUH AVILA GARCIA; | 2024-08-01 |
| 211 | Evaluation of Allocetra By Intra-articular Injection for The Treatment of Psoriatic Arthritis Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label study to evaluate the safety and initial efficacy of intra-articular administration of Allocetra in patients with Psoriatic Arthritis (PsA). |
ENLIVEX THERAPEUTICS | 2024-08-01 |
| 212 | Role of Intra-articular Corticosteroid Injection in Geniculate Artery Embolization for Knee Osteoarthritis: A Comparative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the effectiveness and safety of intra-articular corticosteroid injection (IACI) in alleviating post-procedural pain and improving early outcomes in patients undergoing geniculate artery embolization (GAE) for knee osteoarthritis (OA). The main questions it aims to answer are: – Does intra-articular corticosteroid injection reduce pain levels post-procedure compared to GAE alone? – … |
AHMED AWAD BESSAR; | 2024-07-30 |
| 213 | Comparative Study of CT and Fluoroscopic Guided Genicular Nerve Ablation in The Treatment of Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate the comparative effectiveness of CT-guided and fluoroscopic-guided genicular nerve ablation in reducing knee pain and improving function in adults diagnosed with knee osteoarthritis refractory to conservative treatment. The main questions it aims to answer are: – Does CT-guided genicular nerve ablation provide superior pain relief compared to fluoroscopic-guided genicular nerve ablation? – Is there a significant difference in functional improvement between the two techniques? Researchers will compare the outcomes between the CT-guided and fluoroscopic-guided groups to determine which method achieves better pain relief, functional enhancement, safety profile, … |
AHMED AWAD BESSAR; | 2024-07-30 |
| 214 | Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain Management: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate whether performing genicular nerve ablation (GNA) before geniculate artery embolization (GAE) improves pain relief and knee function in patients with chronic knee pain. The main questions it aims to answer are: – Does performing GNA prior to GAE enhance pain relief, as measured by the Visual Analog Scale (VAS), at 3 months post-procedure? – … |
AHMED AWAD BESSAR; | 2024-07-30 |
| 215 | Long-term Effects of Methotrexate in Adults With Erosive Hand Osteoarthritis: A 30-month Follow-up of Former MERINO Participants (MERINO:2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In response to the high prevalence of synovitis in hand osteoarthritis (OA) and its association with pain, there\'s a compelling rationale for investigating the efficacy of MTX in managing inflammatory erosive hand OA. Recent guidelines highlight the need for large, well-designed trials to assess the effectiveness of MTX. A recent trial (METHODS study) showed promising pain reduction with MTX, but due to pandemic-related protocol changes, the duration of the study was limited to six months. The ongoing MERINO trial randomizes participants to MTX or placebo for one year. After completing the MERINO trial, … |
DIAKONHJEMMET HOSPITAL | 2024-07-29 |
| 216 | Comparison of Radiofrequency Applications and Alcoholic Neurolysis of Genicular Nerve for The Treatment of Knee Osteoarthritic Pain: A Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the efficacy of radiofrequency ablation and alcoholic neurolysis of genicular nerve on alleviating pain and improving the function of advanced knee osteoarthritis patients. |
MOHAMMED SAID ELSHARKAWY; | 2024-07-25 |
| 217 | Investigation of The Effect of Movement Mobilization Concept on Quantitative Sensory Parameters, Pain, Muscle Activation Levels in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Individuals with knee osteoarthritis are one of the groups most affected by musculoskeletal disorders and experience pain and mobility limitations that significantly limit their daily living activities. Quantitative sensory assessment in individuals with osteoarthritis plays a critical role in evaluating disease progression and treatment effectiveness by objectively measuring changes in sensory perception such as proprioception and nociception. These changes in sensory perception can negatively affect individuals’ movement control and balance. In this context, evaluation of quantitative sensory parameters allows the development of more targeted and effective interventions in the rehabilitation processes of individuals with osteoarthritis. Additionally, … |
BURCU PAMUKCU; | 2024-07-25 |
| 218 | Comparison of Percutaneous and Conventional Radiofrequency Applications for The Treatment of Knee Osteoarthritic Pain: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare percutaneous and conventional radiofrequency applications for the treatment of knee osteoarthritic pain. |
MOHAMMED SAID ELSHARKAWY; | 2024-07-25 |
| 219 | Acute Effects of Whole-Body Vibration on Pain, Neuromuscular Performance and Gait Quality in Patients with Knee Osteoarthritis. A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis is a chronic joint disease with an impact on quality of life and an increasing incidence what leads to huge costs and burden on the economy. The present study investigates immediate effects of whole-body vibration on pain, neuromuscular performance, and gait quality in patients with knee osteoarthritis. Eligible patients (n=20) with knee osteoarthritis grade 2 or 3 on Kallgren Lawrence will complete a 5 minute WBV training and a control condition in a randomized order (cross over design). Pain, maximum strength of the leg flexors and extensors, … |
WOLFGANG KEMMLER; | 2024-07-15 |
| 220 | Blood Flow Restriction with Different Loads Versus Moderate Resistive Exercises in Patients with Knee Osteoarthritis: A Double Blinded Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trail will be conducted to investigate the effect of blood flow restriction (BFR) with different load levels between low blood occlusion percentage (50%) group and high blood occlusion percentage (70%) compared to moderate intensity training (60% of 1 RM) in patients with chronic knee osteoarthritis. The main questions it aims to answer are: 1. Will there be no difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on pain intensity in knee osteoarthritis ? 2. Will there be no difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on quadriceps muscle strength in knee osteoarthritis ? 3. Will there be no difference difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on rate of perceived exertion in knee osteoarthritis ? 4. Will there be no difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on functional ability in knee osteoarthritis ? 5. Will there be no difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on physical function in knee osteoarthritis ? All participants will receive: 1. 16 sessions of supervised intervention 2 times per week for 8 weeks. 2. The assessment will be at 3 time points, baseline and at 4 weeks and at 8 weeks. |
FARAH FOUAD GOMAA EL GAMAL; | 2024-07-15 |
| 221 | Quantitative Assessment of BB-02 Therapy Effect on Cartilage Status in Patients Affected By Early Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis is a condition that affects young or middle-aged patients with high functional demands. Knee replacement surgery in patients under 65 years of age is associated with a high risk of failure and the need for revision. For this reason, it becomes crucial to identify treatment alternatives aimed primarily at resolving symptoms but also at slowing down the joint degenerative process, with the goal of delaying the need for prosthetic treatment as much as possible. The medical device BB-02 (IGEA SpA, Carpi, … |
ISTITUTO ORTOPEDICO RIZZOLI | 2024-07-10 |
| 222 | Open-label, Randomized, Assessor-blinded, Efficacy, Safety, Tolerability, and Pharmacokinetics Study of Subcutaneous Risankizumab With An Adalimumab Reference Arm in Children With Active Juvenile Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriatic arthritis (PsA) is a type of arthritis that happens when the body’s immune system attacks healthy cells and tissues causing joint pain, stiffness, and swelling. Symptoms can get worse and go away for periods of time. PsA that begins before a patient’s 16th birthday is called juvenile PsA (jPsA).This study will evaluate how safe risankizumab is for the treatment of psoriatic arthritis and to assess change in disease symptoms. Risankizumab is being studied for the treatment of jPsA and adalimumab is approved for the treatment of jPsA. Participants are placed in 1 of 2 groups, … |
ABBVIE | 2024-07-08 |
| 223 | Active Pharmacovigilance Study of The Medicine Rinvoq™ (Upadacitinib) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The LOOK-UP is an investigator-initiated clinical study with the aim of monitoring the post-marketing safety of the medicine Rinvoq™ (upadacitinib), which is indicated for the treatment of rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, atopic dermatitis, ulcerative colitis, and Crohn’s disease. The Marketing Authorisation Holder is AbbVie Deutschland GmbH & Co. KG. |
INÊS RIBEIRO VAZ; | 2024-07-01 |
| 224 | Validity and Reliability of The Inflammatory Arthritis Facilitators and Barriers to Physical Activity (IFAB) Questionnaire for Individuals With Pediatric Rheumatic Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: No tool has been found to evaluate behaviors that may hinder or facilitate physical activity in individuals with pediatric rheumatic diseases. In this sense, the importance of examining physical activity barriers and facilitators in children with rheumatic diseases is clear. We believe that our study will guide the increase in physical activity, which is very important for reducing disease risks in individuals with pediatric rheumatic diseases. The aim of our study is to examine the validity and reliability of the Inflammatory Arthritis Facilitators and Barriers to Physical Activity (IFAB) Questionnaire in individuals with pediatric rheumatic diseases (juvenile idiopathic arthritis, … |
NILAY ARMAN; | 2024-07-01 |
| 225 | Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Historically, total knee arthroplasty (TKA) has been performed with the goal of restoring a neutral mechanical axis, eliminating the average 3 degrees of valgus and varus of the distal femur and proximal tibia joint lines respectively. This is thought to provide a more stable and neutral joint-bearing surface. Because of this shift to a 0-degree knee angle, soft tissue releases are frequently required to balance the knee after making the distal tibia and proximal tibia cuts. More recently and increasingly, TKAs have been performed with a goal of restoring kinematic, or anatomic, … |
NICHOLAS BROWN; | 2024-07-01 |
| 226 | The Effect of Core Stabilization Training on Pain, Functional Status, Fatigue, and Quality of Life in Patients with Juvenile Spondyloarthropathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Core stabilization exercises developed by McGill have been shown to be one of the physiotherapy techniques aimed at reducing pain, increasing aerobic capacity, enhancing muscle strength, and thereby improving bone health in children with JIA. However, there is no study that has investigated core stabilization training for different types of JIA. In our study, we aim to compare the effectiveness of core stabilization training and a daily physical activity program in children with spondyloarthropathy, to help identify the most effective strategy for clinical practice. Additionally, highlighting the specific effects of core stabilization training on the treatment of juvenile spondyloarthropathy (pain, … |
GOKCE LEBLEBICI; | 2024-07-01 |
| 227 | Comparative Effects of Mulligan and Maitland Techniques on Pain, Range of Motion and Functional Disability in Post Prp Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis (OA) is a major cause of disability nowadays. Osteoarthritis (OA), also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage. It is most common in elderly people and can be divided into two types, primary and secondary. Platelet-rich plasma (PRP) is an autologous blood product that contains a high concentration of platelets, specifically, 3 to 5 times that of normal blood. PRP contains a high concentration of autogenous growth factors, including vascular endothelial growth factor, platelet-derived growth factor, and transforming growth factor-β, … |
MUQADDAS SHAREEF; | 2024-07-01 |
| 228 | Analgesia for Total Hip Arthroplasty With PENG Block (ATHAPENG) PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Total hip arthroplasty (THA) for osteoarthritis is a commonly performed surgery worldwide. It is associated with significant pain, with median pain scores in the first 24 hours … |
HOSPICES CIVILS DE LYON | 2024-06-25 |
| 229 | A Single Center, Randomized, Double-blind, Single Dose Bioequivalence Trial of Genakumab in Chinese Healthy Male Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate whether Genakumab Injection is bioequivalent to Genakumab for Injection. |
CHANGCHUN GENESCIENCE PHARMACEUTICAL | 2024-06-24 |
| 230 | Prospective Trial of The OrthoCor Advanced System for Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this clinical trial is to show that PEMF therapy, heat, recovery metrics, and compliance data provided by the OrthoCor Advanced System improves pain and quality of life for patients with osteoarthritis. The main question it aims to answer is: Does therapy from the OrthoCor Advanced System improve symptoms of osteoarthritis? Researchers will compare range of motion measurements, sit to stand test results, … |
JOSHUA G HACKEL; | 2024-06-18 |
| 231 | Effects of Black Cumin and Turmeric Along With Quantum Acoustic Waves on Inflammatory Markers and Pain in Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis is a chronic inflammatory disease that directly affects the quality of life and financial burden. The understanding of the mechanism and available intervention strategies can not minimize its incidence that increased by 1/10 since 1990. The combination of black cumin and turmeric with sound waves is not well known. |
MUHAMMAD FAEEM AFZAL; | 2024-06-15 |
| 232 | Mechanical Knee Decompression With and Without Heating: Impact on Pain, Function, and Range of Motion PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: a randomized controlled trial tends to compare the effects of adding superficial heating during the application of knee decompression session to the results of decompression alone without heating. |
HISHAM MOHAMED HUSSEIN; | 2024-06-15 |
| 233 | Assessing The Efficacy of Ginger Powder Capsules As An Analgesic for Intraoperative and Post- Endodontic Pain Management in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate the analgesic effect of ginger powder capsules compared to placebo on intra-operative and post-operative pain of single-visit endodontic treatment of mandibular molars with symptomatic irreversible pulpitis. |
OMAR ALDERBASHI; | 2024-06-15 |
| 234 | Effects of Mulligan Mobilization With Movement As Compared to Kaltenborn Joint Mobilization in The Management of Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomised controlled trial and the purpose of this study is to determine the Effects of Mulligan mobilization with movement as compared to Kaltenborn joint mobilization in the management of knee osteoarthritis. To determine the effects of Mulligan MWM as compared to Kaltenborn joint mobilization in terms of pain, function, range of motion and gait in persons with knee osteoarthritis. |
SHANZA FATIMA; | 2024-06-10 |
| 235 | Effect of NMES As An Add-On to Exercise Program in Degenerative Meniscus Tears: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized-controlled trial aims to investigate the effect of NMES as an add-on to an exercise program in patients with degenerative meniscus tears. |
TANSU BIRINCI; | 2024-06-10 |
| 236 | SUPPLEMENTARY EFFECTS OF RESISTANCE TRAINING IN ADDITION TO JOINT MOBILIZATION IN PERSONS WITH KNEE OSTEOARTHRITIS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Joint mobilization and resistance exercise training are effective conservative treatment options for the management of osteoarthritis. However, currently no study has highlighted the supplementary effects of resistance training in addition to joint mobilization in people suffering from knee osteoarthritis. The current study is aimed at bridging the gap in literature and providing evidence regarding the additive impact of resistance training to joint mobilization in knee osteoarthritis. |
WANIA MAHEEN; | 2024-06-10 |
| 237 | Comparison of The Open Kinetic Chain and Closed Kinetic Chain Strengthening Exercises on Pain, Function, and Health-related Quality of Life in Degenerative Meniscus Tears PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized-controlled trial aims to compare the effect of open kinetic chain and closed kinetic chain strengthening exercises on pain, function, and health-related quality of life in degenerative meniscus tears. |
TANSU BIRINCI; | 2024-06-10 |
| 238 | Effect of Transcutaneous Auricular Electroacupuncture on Sleep Disturbances in Patients with Rheumatoid Arthritis: A Randomized Double-Blind Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to determine whether transcutaneous auricular vagus nerve stimulation (taVNS) is suitable for improving sleep disorders in patients with rheumatoid arthritis (RA). It will also evaluate the safety of taVNS. The main questions it aims to answer are: Can taVNS improve the sleep quality of RA patients? What medical issues might RA patients experience while receiving taVNS treatment? Researchers will compare taVNS with a placebo (a similar substance that does not contain the actual treatment) to see if taVNS is effective in improving sleep disorders in RA patients. Participants will: Receive taVNS or sham stimulation daily for 4 weeks Keep a daily sleep diary and visit the hospital once a week for check-ups and tests Record their sleep quality and related symptoms This study aims to provide a new, safe, and effective non-drug therapy for sleep disorders related to RA. |
JUAN JIAO; | 2024-06-06 |
| 239 | Adherence and Clinical Outcomes in Patients With E-Device for Etanercept Administration in Rheumatoid Arthritis Patients: Real Word Evidence in A Colombian Institution PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a descriptive, ambispective, and single-site study in Colombia, which is designed to evaluate the adherence, persistence, and clinical outcomes (defined as the patient’s disease activity and functional status) of RA patients within 40 weeks after the patient administered the first injection of the etanercept medication through the Smartclic® device. The study data seeks from medical records containing the Smartclic device injection log and pharmacy claims database available from an institution specialized in rheumatological care. The study will only include records of patients treated or starting treatment with etanercept and whose indicated autoinjection device has been Smartclic. |
PFIZER | 2024-06-06 |
| 240 | Treatment of Patellofemoral Osteoarthritis With Nasal Chondrocyte-based Engineered Cartilage Implantation in A Randomized, Controlled, Multi-center Phase II Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this investigator-initiated study is to assess the efficacy of treating patellofemoral osteoarthritis with an Advanced Therapy Medicinal Product (ATMP), autologous nasal chondrocyte tissue engineered cartilage (N-TEC), in comparison with a standard therapy using platelet rich plasma injections. The engineered cartilage graft is obtained by culturing expanded autologous nasal chondrocytes within a collagen type I/III membrane. |
MARCUS MUMME; | 2024-06-06 |
| 241 | Metformin Treatment of Patients with Hand Osteoarthritis: A Randomised, Placebo-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare metformin (2 g daily), or maximum tolerated dose, for 16 weeks with placebo as a treatment of hand osteoarthritis symptoms. |
MARIUS HENRIKSEN; | 2024-06-03 |
| 242 | A Clinical Study to Assess The Efficacy of Cannabigerol in Patients With Active Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-group exploratory longitudinal prospective study lasting 8 weeks. The study aims to measure the efficacy of purified cannabigerol (CBG) in patients with active rheumatoid arthritis using laboratory and self-reported outcome measures. |
RAPHAEL PHARMA | 2024-06-03 |
| 243 | The Effect of Low Dose Pregabalin and Etoricoxib Combination on Pain in Comparison to Etoricoxib Alone in Patients Suffering From Chronic Low Back Pain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effects of pregabalin in reducing pain intensity and improving functional disability in patients with chronic low back pain of neuropathic origin when used in combination with Etoricoxib. Hypothesis Pregabalin-etoricoxib combination is more effective than etoricoxib monotherapy in reducing pain and improving functional status in patients with chronic low back pain. Null Hypothesis: There is no significant difference between pregabalin-etoricoxib combination and etoricoxib monotherapy in reducing pain and improving functional status in patients with chronic low back pain. Study Design: Comparative clinical study Setting: Watim General Hospital Duration of study: 18 months after ethical approval Sample Size: a previous study (8), was used to calculate the sample size, Using the WHO sample size calculator, a sample size of 140 patients (70 in each group) was determined with a 5% level of significance and 95% power of test. Sampling Technique: non-probability convenience sampling. Sample selection Inclusion criteria: – Participants within age 20-65 years – Both male and non-pregnant non-lactating female patients will be included in the study – Patients experiencing CLBP symptoms from last 6 months – No experience of previous low back surgery Exclusion Criteria: – Patients with the history of antidepressant, opioid, and benzodiazepine medications – Patients with the history of CYP1A2 inhibitors usage – Patients already taking pregabalin – Patients with the history of suicidal ideation, severe depression, anxiety disorder psychosis, and cognitive impairment Data collection Participants will be divided into two study groups. Group A (n=70) participant will receive 60mg Etoricoxib once daily along with a placebo and Group B (n=70) participants will also receive etoricoxib 60mg once daily(15) along with a placebo for 4 weeks. At the start of week 5 the group B will start taking Pregabalin 75mg along with Etoricoxib 60mg once daily for next 4 weeks, while, group A will continue same treatment as before. At Weeks 0 and 4 and 8 of the study, participants will be evaluated. Liver enzyme levels will be measured both at the beginning and end of the trial. The pain will be measured using numeric rating scale (NRS). CLBP-related impairment will be evaluated using the self-reported 24-item Roland-Morris impairment Questionnaire (RMDQ) |
MUHAMMAD ILYAS; | 2024-06-01 |
| 244 | The Effect of Psoriatic Arthritis on Female Sexual Dysfunction and Their Relation to Sex Hormones PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders. |
EGYMEDICALPEDIA | 2024-06-01 |
| 245 | Knowledge Translation and Exercise for Degenerative Meniscal Tears and Early Osteoarthritis: The KNEE-DEeP Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee pain due to a degenerative meniscal tear (DMT) or early osteoarthritis (OA) is a frequent presentation in middle-aged and older adults. In the knee joint a DMT can occur normally with age, but is also associated with the continuum of knee OA. Exercise is recommended as the main treatment to aid recovery, while an arthroscopy (camera in the knee) to remove torn cartilage does not provide any additional benefit. Despite this many patients in Ireland with this type of knee pain are referred to an orthopaedic surgeon by their GP, … |
HELEN O’LEARY; | 2024-06-01 |
| 246 | Effects of Agility and Perturbation Based Training in Addition to Routine Physical Therapy on Pain, Function and Quality of Life in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis is a degenerative joint disease. Knee OA patients sometimes report episodes of knee instability that limit their ADLs. The episodes of instability are similar to those reported in knee ligament injuries. It is believed that modifications of interventions that are used to promote knee stability in knee ligament injuries can be used in knee OA to enhance knee stability and function. The purpose of this study will be to determine the effects of agility and perturbation-based training in addition to routine physical therapy on pain, function, quality of life and disability in knee osteoarthritis. |
MARYAM IJAZ; | 2024-06-01 |
| 247 | COMPARISON OF PERIOPERATIVE ANALGESIC EFFECTIVENESS OF PATIENTS WHO HAD FASIA ILIAC COMPARTMENT BLOCK AND 4IN1 BLOCK APPLIED IN TOTAL KNEE PROSTHESIS SURGERY PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients who will undergo elective total knee arthroplasty surgery under spinal anesthesia will be included in the study according to the postoperative analgesia method applied: Group Control, Group FICB and Group 4in1. Peripheral nerve block will be performed with 30 ml %0.25 bupivacaine for Group FICB and Group 4 in 1 patients. Peripheral nerve block will not be performed on Group Control patients. Patient-controlled analgesia will be given to all three groups in the postoperative period. PCA is a pain palliation method routinely used in all patients postoperatively. NRS score, PCA tramadol consumption, PCA demand, need for additional analgesia, … |
SAVAS ALTINSOY; | 2024-06-01 |
| 248 | Effects of Ultrasound-guided Genicular Nerve Block in Knee Osteoarthritis Patients on Proprioception and Static Balance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Genicular nerve block (GNB) is a novel and promising interventional method for pain in knee osteoarthritis (KOA). However ,it contains afferent fibers that receive impulses from proprioceptive and deep sensory receptors located in the joint capsule, ligaments, muscles, tendons and periosteum. These proprioceptive stimuli are effective on joint position and biomechanics, protect the joint from injuries and help maintain balance. This study aims to evaluate Pproprioception and static balance after ultrasound-guided GNB in patients with knee osteoarthritis. |
ANKARA CITY HOSPITAL BILKENT | 2024-06-01 |
| 249 | Efficacy of High Power Laser Versus Low Level Laser in Ultrasonographic and Functional Outcomes in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: this study will be conducted to compare between high power laser and low-intensity laser on ultrasonographic and functional outcomes in patients with knee osteoarthritis |
NABIL MAHMOUD ISMAIL ABDEL-AAL; | 2024-05-30 |
| 250 | Effect of A Sequence of Specific Manual Therapy Techniques Targeting The Autonomic Nervous System in Healthy Adults: A Single-application Double-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The activity of the autonomic nervous system has been shown to influence the appearance of symptoms in some diseases such as rheumatoid arthritis, fibromyalgia, or migraine, among others. In the bibliography we find different authors who, through intervention using manual therapy, have demonstrated its effects on the autonomic nervous system, especially on the increase in parasympathetic activity and reduction in sympathetic activity. A clinical trial is proposed to verify these effects. |
PERE RAMÓN RODRÍGUEZ RUBIO; | 2024-05-23 |
| 251 | Coexistence of Night Pain and Neuropathic Pain in Patients with Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim is to investigate the frequency and severity of neuropathic pain and its association with night pain in patients with knee osteoarthritis. For this purpose a progressive longitudinal study design was planned. The secondary aim is to investigate the relationship between night pain and neuropathic pain and sleep quality. |
TACISER KAYA; | 2024-05-16 |
| 252 | Comparative Effectiveness of New Initiators of Tofacitinib and Other Biologic/Targeted Synthetic DMARDs in Patients With Rheumatoid Arthritis PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn how different types of medicines may improve disease activity in people with rheumatoid arthritis (RA). RA is a kind of joint disease that causes pain and swelling. The study will look at data from a large, US-based group of RA patients who have taken the below medicines: – Tofacitinib – Abatacept – Tocilizumab or sarilumab The study will compare clinical disease activity scores of patients on the different medicines taken. The study will also decide whether some patient traits or disease factors play a role in how medicines may improve disease activity. |
PFIZER | 2024-05-15 |
| 253 | Exercise-induced Hypoalgesia in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to evaluate the differences in the phenomenon of exercise-induced hypoalgesia in patients with osteoarthritis. |
LUIS SUSO; | 2024-05-15 |
| 254 | Motor Imagery and Action Observation in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to evaluate the effects of an exercise programme combined with motor imagery and action observation, both in the short and long term. |
LUIS SUSO; | 2024-05-15 |
| 255 | Muscle Fatigability and Trip-specific Fall Risk in Adults With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about how fatigue affects the risk of falling in adults aged 55-70 years with and without knee osteoarthritis. The main questions this trial aims to answer are: * Does fatigue increase the risk of tripping while walking? and * Does fatigue increase the risk of falling in response to a trip while walking? Participants will * Complete questionnaires * Wear a device that measures physical activity for 5-7 days * Complete a 30 minute walk on a treadmill * Complete the following before and after the treadmill walk: * Computer test to measure mental fatigue * Maximal strength testing * Balance test Researchers will compare adults with and without knee osteoarthritis to see if fall risk in adults with knee osteoarthritis is affected more by walking activity compared to adults without knee osteoarthritis. |
UNIVERSITY OF DELAWARE | 2024-05-14 |
| 256 | An Open-label, Multiple Dose, Multicenter Study to Evaluate The Pharmacokinetics, Safety, and Tolerability of Filgotinib in Children and Adolescents From 8 to Less Than 18 Years of Age With Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Study to evaluate the pharmacokinetics, safety, and tolerability in paediatric population for treating juvenile idiopathic arthritis (JIA). |
ALFASIGMA S P A | 2024-05-13 |
| 257 | ACP Max™ PRP System for Knee Osteoarthritis: A Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective, multicenter (up to 4 sites), randomized, double-blind, two-arm study. Forty-five (45) patients will be randomized to receive a single 4-6 ml intra-articular (IA) injection of either the output of ACP Max™ (n=30) or 6 ml of Depo-Medrol® (methylprednisolone acetate) (n=15). |
ARTHREX | 2024-05-13 |
| 258 | Preventing Muscle Wasting During Rheumatoid Arthritis Flares: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: People living with Rheumatoid Arthritis (RA) often present with low muscle mass compared to their healthy counterparts. This affects their mobility, overall health and quality of life. Even though low muscle mass in RA has been recognised for decades, it is still highly prevalent and very little is known about its development, progression, and potential management. The researchers hypothesise that flares of disease activity trigger acute events of muscle wasting due to high inflammation and reduced mobility. This is commonly observed in bed rest studies and people hospitalised for various reasons. If this holds true for RA, … |
LEEDS BECKETT UNIVERSITY | 2024-05-13 |
| 259 | Quantifying The Movement Dynamics of Adults Living with Total Knee Arthroplasty and Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and healthy individuals. |
JOSIE MORRIS; | 2024-05-07 |
| 260 | Preventing Injured Knees From OsteoArthritis: Severity Outcomes (PIKASO) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction. This research study will compare metformin to placebo. The placebo tablet looks exactly like metformin, but contains no metformin. Placebos are used in research studies to see if the results are due to the study drug or due to other reasons. Metformin is approved by the U.S. Food and Drug Administration (FDA) to treat type II diabetes. Notably, it also has anti-inflammatory effects, … |
MORGAN H. JONES; | 2024-05-06 |
| 261 | Effect of Preoperative Combined Care Guidance on Pain, Anxiety and Joint Range of Motion in Patients Undergoing Total Knee Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effectiveness of combined care guidance and general care guidance on pain scores, anxiety levels and joint mobility in patients undergoing total artificial knee replacement. The main questions it aims to answer are: – Does combined care coaching reduce patient pain scores and anxiety levels after surgery? – Does combined care guidance improve knee joint mobility after surgery? Researchers will compare combined care guidance and general care to see if combined care guidance reduces patients’ pain scores and anxiety levels after surgery, … |
LI YING-HUNG; | 2024-05-01 |
| 262 | Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The EDUEX trial will determine whether the addition of progressive resistance training (PRT) to a patient education program (EDU) will improve clinical outcomes in patients with hip OA. In a subsample, the effect of PRT on the articular cartilage and other structures of the hip joint is investigated. In this subsample, a comprehensive assessment of possible mechanisms underlying the effects of exercise on pain and function is undertaken. The EduEx trial will be a multicentre, stratified (by site), block randomized (allocation 1:1), controlled, parallel-group superiority trial. 150 people with hip OA will be recruited from hospitals, physiotherapy clinics, … |
TROELS KJELDSEN; | 2024-05-01 |
| 263 | Revealing The Potential of Intravenous Pulse Steroid Therapy; Impressive Results in Attaining Remission or Low Disease Activity in Refractory Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Remission or low disease activity in active rheumatoid arthritis |
AHMED MAHROUS; | 2024-05-01 |
| 264 | The Efficacy of Intravenous Pulse in Attaining Remission in Refractory Juvenile Idiopathic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Interventional phase 3 study aiming to unravel the value of pulse steroids in achieving remission or low disease activity in refractory active JIA |
AHMED MAHROUS; | 2024-05-01 |
| 265 | Self-management Nursing Intervention for Women With Rheumatoid Arthritis: A Pragmatic Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction. Chronic autoimmune diseases are catalogued as catastrophic conditions that generate a negative impact on the health and well-being of the affected person. In this particular case, rheumatoid arthritis is its main representative, which is a predominant disease in women, affecting not only the musculoskeletal system but in general, all dimensions of the human being and generating great costs for health systems. Adaptation to living with the disease requires the individual to develop capacities for a positive management of the condition, and in this sense, … |
VANESSA BURBANO; | 2024-05-01 |
| 266 | Comparative Effects Of Dynamic And Static Stretching On Pain, Lower Extremity Function And Knee Range Of Motion In Postmenopausal Females With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As the aging population continues to grow, there is a pressing need to explore effective interventions to alleviate the symptoms of osteoarthritis, particularly in postmenopausal women who may experience unique challenges. Osteoarthritis (OA) is progressive joint disease characterized by joint inflammation and a reparative bone response and is one of the top five most disabling conditions that affects more than one-third of persons >65 years of age, commonly affecting hands, feet, spine, hips, and knees. Among the various therapeutic modalities, stretching exercises, both dynamic and static, have gained attention for their potential to enhance joint flexibility, reduce pain, … |
TANZEELA MAJEED; | 2024-04-24 |
| 267 | INFINITY™ With ADAPTIS™ and EVERLAST™ Technology Total Ankle Replacement Follow-up PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: An ankle replacement procedure consists of replacing the worn-out joint surfaces of the ankle with metal and plastic components that are shaped to allow continued movement of the ankle. There are several different types of ankle replacement available. Infinity ankle implants are already routinely used in NHS hospitals. The INFINITY™ with ADAPTIS™ and EVERLAST™ ankle replacement system is a development of the Infinity ankle implant, … |
NORTHUMBRIA HEALTHCARE NHS FOUNDATION TRUST | 2024-04-23 |
| 268 | The Effect of Virtual Reality Application Applied to Patients with Total Knee Replacement At Different Times on Anxiety and Recovery Quality PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to examine the effect of virtual reality application on anxiety and quality of recovery at different times (preoperatively and intraoperatively) in patients undergoing total knee replacement. |
ÖZGE İŞERI; | 2024-04-21 |
| 269 | A Prospective Real-World Evidence Study Evaluating The Effects of Voltaren Use on Mobility and Quality of Life in Participants With Knee Osteoarthritis (OA) Pain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate how topical diclofenac use can improve functional mobility and physical activity primarily, as well as other quality-of-life (QoL) parameters such as sleep, mood, and engagement in daily activities in participants with knee OA. |
HALEON | 2024-04-19 |
| 270 | MRI-based Graft Maturity After Blood Flow Restriction Training in Bone-patellar Tendon-bone Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale Graft maturity is correlated with strength and biomechanical properties of the reconstructed ACL. There are concerns that heavy-load resistance training (HLRT) may have detrimental effects on ACL graft maturation. Therefore, low-load blood flow restriction training (LL-BFRT) has been suggested as an alternative to HLRT. As LL-BFRT is an increasingly popular method for the rehabilitation after an ACL reconstruction, … |
JASPER MOST; | 2024-04-17 |
| 271 | Prevention of Post MEniscectomy Osteoarthritis: From New Animal Model to Patient PRofiLing (PEARL) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Data collection from patients included in the observational clinical study will be achieved by the following activities: A total of 100 patients with degenerative meniscal tears will be enrolled in the observational study and treated according to the current standard of care which consists in an arthroscopic partial meniscectomy in all the three clinical operative Unit involved in the project. Demographic, anamnestic and clinical data (age, gender, BMI, habits, co-morbidities, … |
ISTITUTO CLINICO HUMANITAS | 2024-04-15 |
| 272 | Effect of Antigravity Treadmill Training on Pain, Gait Characteristics, and Function in Patients With Knee Osteoarthritis- A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To date, the anti-gravity treadmill, as a representative method of lower body positive pressure treadmills, has been rarely reported for knee osteoarthritis rehabilitation. Purpose: This study aims to evaluate the effect of antigravity treadmill training on pain, gait characteristics, and function in patients with knee osteoarthritis. |
PRINCE SATTAM BIN ABDULAZIZ UNIVERSITY | 2024-04-07 |
| 273 | Effectivity of Allogenic Umbilical Cord Mesenchymal Stem Cells Conditioned Media for Osteoarthritis of The Knee Joint: A Clinical Study of Functional Score and Magnetic Resonance Imaging Evaluation Using CartiGram PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is a joint disorder that often occurs and causes disability. This disorder is characterized by an inflammatory reaction in the synovial joints accompanied by a gradual degeneration process in the articular cartilage and sub-chondral bone. Current research has discovered that stem cells produce conditioned media (secretome, extra vesicles, and exosomes) that have tissue regeneration, immunomodulation, anti-inflammatory, and anti-apoptotic capabilities. Research on conditioned media for umbilical cord mesenchymal stem cells is still at the in vivo stage in experimental animals. For this reason, … |
BINTANG SOETJAHJO; | 2024-04-03 |
| 274 | Long Term Results After Hip Arthroscopy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A common cause of hip joint pain in the young and active population is femoroacetabular impingement (FAI) syndrome. if FAI is left untreated, the changed morphology will have a negative effect on the existing joint and will contribute to the development of osteoarthritis (OA). Hip arthroscopy is the first choice of operative treatment for FAI. While hip arthroscopy improves the patient reported outcome measures (PROMs), the influence of this treatment on the contribution to the development of osteoarthritis after FAI is to the best of our knowledge still unknown. |
REINIER HAGA ORTHOPEDISCH CENTRUM | 2024-04-01 |
| 275 | Clinical Interpretation and Cutoff Scores for Manual Ability Measured By The ABILHAND Questionnaire in Individuals With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In individuals with rheumatoid arthritis, the most significant symptom is the loss of manual ability and function in the hands. In rheumatoid arthritis, where patient-reported assessment scales are frequently used, hand skills should be evaluated with an ideal questionnaire that best represents hand activities. The ABILHAND-RA questionnaire possesses all these features, being a short and easily fillable survey. The aim is to determine of clinically significant cutoff scores for perceived manual ability evaluated by ABILHAND corresponding to observed and perceived upper extremity assessments in individuals with rheumatoid arthritis. |
BERNA CAGLA BALKISLI; | 2024-04-01 |
| 276 | Analgesic Effects of A Treatment With Cannabis Sativa Extract in Patients With Knee Osteoarthritis – CANOA (Cannabis for Osteoarthritis) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is the most prevalent joint disease in humans, often causing disability in affected individuals, especially the elderly. OA is featured by mechanical articular pain, crackling and short post-immobilization stiffness. OA pain has variable pathophysiology, and despite many pharmacological options available, its treatment is often ineffective and presents significant side effects. On this way, the search for more effective and safer treatments is paramount on the OA field. Among potential treatments are the Cannabis-derived substances. Cannabis plants have been used for diverse purposes by mankind over thousands of years. Its best-known species, Cannabis sativa, … |
FEDERAL UNIVERSITY OF LATIN AMERICAN INTEGRATION | 2024-04-01 |
| 277 | Comparison of The Effects of Genicular Radiofrequency Ablation and Pulsed Radiofrequency Applications on Pain Levels in Patients with Osteoarthritis, Guided By Ultrasound” PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the effectiveness of two treatments-genicular nerve radiofrequency ablation and pulsed radiofrequency-in reducing pain and improving function in osteoarthritis patients. These techniques, used after diagnostic nerve blocks, aim to provide long-lasting pain relief. Despite both being found effective, no clear consensus exists on which method is superior. The study seeks to compare these techniques and contribute new insights to the existing literature. |
ÜLKÜ SABUNCU; | 2024-04-01 |
| 278 | Effects of Exercise Programs on Gait in Children With Scoliosis Diagnosed Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Juvenile Idiopathic Arthritis (JIA) is one of the common chronic diseases in childhood. Problems such as weakness or pain may occur in JIA, especially in the joints and the muscles around the trunk (1). These conditions may lead to abnormal displacement of the center of gravity, deterioration of biomechanics, and muscle imbalance in children with JIA (2, 3). All these situations can lead to scoliosis, which we often encounter in children with JIA. Current studies describing various 3-dimension (3D) exercise methods (SEAS, Schroth, Dobomed, BSPTS, Side-shift, Lyon, etc.) effective on scoliosis (4). However, … |
GOKCE LEBLEBICI; | 2024-04-01 |
| 279 | Prevalence of Migraine and Neuropathic Pain in Osteoarthritis: Multicenter, Multidisciplinary, Cross-sectional Epidemiological Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to estimate the frequency of neuropathic pain and migraines in a group of patients with osteoarthritis of the knees, hips, hands, spine or other joints. In addition to their usual care for osteoarthritis, participants will complete questionnaires to define migraine and neuropathic pain. |
SYLVAIN MATHIEU; | 2024-03-27 |
| 280 | The Effect of Mobile Application-Based Care on Functional Status And Self-Care Agency in Patients Undergoing Total Knee Replacement PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Total knee prosthesis (TKP); It is a surgical treatment used in the management of functional limitations and severe pain occurring on the degenerated joint surface as a result of rheumatoid arthritis, osteoarthritis, posttraumatic arthritis and other nonspecific arthritis. Nursing care is of great importance in the success of TKP surgery. Reducing pain, preventing complications, increasing self-care ability, and improving the quality of life by improving postoperative knee functions are the main goals of postoperative nursing care. In order to achieve these goals, … |
SINOP UNIVERSITY | 2024-03-27 |
| 281 | Evaluation of The Effectiveness of Manual Therapy in Patients With Knee Osteoarthritis: Randomized Controlled Single-blind Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effects of three different applications (Manual therapy, electrotherapy and home program) on long-term pain, joint range of motion and, secondarily, the functional level of the knee. |
TUĞBA GÖNEN; | 2024-03-25 |
| 282 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase II Clinical Study to Evaluate The Efficacy and Safety of 608 in Patients with Non-radiographic Axial Spondyloarthritis (nr-axSpA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effect and safety of 608 in patients with nr-axSpA. |
XIAOFENG ZENG; | 2024-03-22 |
| 283 | Analysis of Dry Needling Combined With An Exercise Program in The Treatment of Osteoarthritis Knee: Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthrosis (OA) is a chronic degenerative disease that affects the joints, knee OA is the most prevalent type, affecting 265 million people worldwide, more than 40% of adults over 45 years of age, being one of the greatest causes of disability, which leads to a decrease in the quality of life of those who suffer from it, and increased medical care and costs. Currently, clinical guidelines recommend physical exercise as the first line of treatment for knee OA. Reviews conducted in 2020 observe a low level of evidence regarding dry needling in subjects with OA, … |
MANUEL ALBORNOZ CABELLO; | 2024-03-20 |
| 284 | Test-Retest Reliability and Concurrent Validity of The 3 Meter Backward Walk Test in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis of the knee is a common joint disease that causes loss of balance and proprioception. Changes in the knee joint such as mechanoreceptor loss, muscle strength imbalance, muscle weakness, capsular hypertrophy, subchondral edema, and increased loss of balance and proprioception lead to an increased risk of falls. In the literature, knee osteoarthritis is repeatedly mentioned as an independent risk factor for falls, and knee osteoarthritis is associated with recurrent falls. There are many performance-based clinical measurement tests that assess fall risk in knee osteoarthritis. Some of these tests include the timed up and walk test, the five-step sit-to-stand test, … |
MARMARA UNIVERSITY | 2024-03-15 |
| 285 | Geriatric Locomotive Syndrome Kinesiophobia, Physical Activity Level, Physical Performance, Fatigue, Cognitive Functions in Older Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It has been stated that the results of physical function and physical performance affecting locomotive syndrome in elderly individuals are controversial and studies are still needed. However, no studies have been found examining its relationship with the decrease in physical activity level, decline in cognitive functions, kinesiophobia (fear of movement) and fatigue seen in old age. Early detection of locomotive syndrome risk factors in elderly individuals will help prevent this condition, detect the risk of falling in elderly individuals and increase their quality of life. Based on these deficiencies, … |
AYŞE ABIT KOCAMAN; | 2024-03-07 |
| 286 | A Multi-centre Feasibility Study Assessing Shoe-worn Insoles to Improve Clinical and Biomechanical Features of Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Shoe-worn insoles (also known as orthotics) can provide symptomatic relief for people with knee osteoarthritis. However, given they act at the feet, and given that many people with knee osteoarthritis also report foot pain, it is important to assess the effects of these devices at both joints. We will conduct a multi-centre randomized pilot trial to determine feasibility and preliminary efficacy. |
MICHAEL HUNT; | 2024-03-04 |
| 287 | Title of Study: Eating Habits and Symptom Severity in Autoimmune Diseases: A Patient Survey PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to collect information on rheumatology patients’ dietary habits, autoimmune disease activity, dietary changes, disease symptom improvements, and perceptions on their dietary habits and how it affects their autoimmune disease. The main objective is to see if rheumatology patients change their dietary habits after their diagnosis of an autoimmune disease and if it subjectively improved their disease symptoms. It will also look at rheumatology patients’ expectations for their rheumatologist when it comes to dietary advice and what resources they used to choose their new dietary habits. The study also seeks to measure the interest that rheumatology patients have in pursuing dietary changes as a means of controlling the symptoms of their autoimmune disease. It is expected that patients who changed their eating habits to healthier diets such as a Mediterranean diet would report less severe autoimmune disease symptoms. There are limited dietary recommendations for the management of many rheumatological diseases, so this study seeks to assess rheumatology patients’ willingness to try dietary modifications, what improvements they had, and why they decide to make these changes in light of limited information. |
NEHA BHANUSALI; | 2024-03-01 |
| 288 | The PASSPORT Trial: Pharmacokinetics, Efficacy and Safety of CT-P13 Subcutaneous As Induction Therapy in Patients With Active Crohn’s Disease or Ulcerative Colitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare induction treatment with CT-P13 SC to induction treatment with CT-P13 IV in terms of pharmacokinetics in adult patients with inflammatory bowel disease (IBD) who have been diagnosed for at least 3 months and for whom the physician has decided to initiate treatment with infliximab CT-P13 as part of the standard of care. The main aim of this study is to demonstrate that induction treatment with CT-P13 SC is non-inferior to CT-P13 IV in terms of pharmacokinetics at Week 6. |
YORAM BOUHNIK; | 2024-03-01 |
| 289 | Investigation of The Effect of Nonsurgical Periodontal Treatment Applied Together With Anti-TNF-α on Alveolar Bone Loss and Oxidative Stress in Patients With Rheumatoid Arthritis and Periodontitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Periodontitis is a multifactorial disease of the periodontium that can lead to destruction of the alveolar bone and supporting connective tissue and subsequent tooth loss. Recent studies have shown that periodontitis is associated with age, smoking habits, genetic predisposition, socioeconomic status, and various systemic diseases such as diabetes mellitus, atherosclerosis, obesity, osteoporosis, and rheumatoid arthritis (RA). RA is a chronic, systemic inflammatory disease of unknown etiology that primarily affects the joints. Periodontitis and RA have similar clinical and pathogenic features. Clinically, … |
HATICE YEMENOĞLU; | 2024-03-01 |
| 290 | The Effects of Kinesio Taping on Knee Pain, Range of Motion, and Functional Performance in People With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effectiveness of Kinesio Taping in individuals with knee osteoarthritis (KOA). KOA is a common condition that can lead to pain, stiffness, and decreased mobility. The main questions it aims to answer are: – Does Kinesio Taping reduce pain in individuals with KOA? – … |
MARWAN MAHMOUD ALJOHANI; | 2024-03-01 |
| 291 | Effectiveness of Dry Needling With or Without Mulligan Two Leg Rotation Technique on Pain, Range of Motion and Joint Dysfunction in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of study is to determine the effectiveness of dry needling with or without mulligan two leg rotation technique on pain, range of motion and joint dysfunction in knee osteoarthritis. The study will be a single blinded randomized controlled trial conducted at the Physical Therapy Department of Hussain Memorial Hospital, focusing on the treatment of knee osteoarthritis in adults aged 40 to 80 years. |
MUHAMMAD NAVEED BABUR; | 2024-03-01 |
| 292 | A Phase Ia, Multicenter, Double-Blind, Placebo-controlled Study to Evaluate The Safety of CYT-108 for The Therapy of Mild to Moderate Primary Osteoarthritis of The Knee PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this Phase 1 study is to investigate the safety of CYT-108, our experimental recombinant protease inhibitor drug candidate for osteoarthritis, in a population of patients suffering from osteoarthritis of the knee. The main questions this study aims to answer are: 1. are two doses of CYT-108, delivered 12 weeks apart, safe when injected directly into the joint? 2. does administration of CYT-108 result in a reduction in pain, stiffness, and improvement in daily physical function? Participants will either receive a placebo (Phosphate Buffer Saline, PBS) or CYT-108, … |
CYTONICS | 2024-03-01 |
| 293 | Association Between Severity of Periodontitis and The Level of Anti-citrullinated Protein Antibodies (ACPAs) in Rheumatoid Arthritis Patients Before and After Non-surgical Periodontal Treatment (Pre and Post Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics. The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid before and after non-surgical periodontal treatment and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients |
ZAINAB HAFEZ; | 2024-03-01 |
| 294 | Application of Auriculotherapy in Enhanced Recovery After Surgery of Total Knee Arthroplasty for Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To further improve the surgical outcomes of patients undergoing total knee arthroplasty (TKA). This study aims to use ear acupoint therapy to address the following clinical issues: 1 The degree of postoperative inflammation and edema in the patient; 2. Patient pain; 3. Patient functional recovery. 4. Surgical scar repair for patients; 5. Patient perioperative anxiety and postoperative satisfaction. Exploring the safety and effectiveness of ear acupoint therapy in the postoperative application of TKA, leveraging the advantages of suitable traditional Chinese medicine techniques in simplicity, convenience, effectiveness, and cost-effectiveness, … |
QINDONG MI; | 2024-03-01 |
| 295 | Comparing The Effect of Toe-in Gait Modification Along With Conventional Physiotherapy in People With Medial Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Medial knee osteoarthritis (OA) remains a prevalent and debilitating condition, despite conventional physiotherapy interventions aimed at reducing pain and improving function. This study investigates the additional benefits of toe-in gait modification when combined with conventional physiotherapy in individuals with medial knee OA. Rooted in biomechanical theories suggesting that altering gait patterns can reduce medial knee load, this research employs a randomized controlled trial methodology. |
MUHAMMAD NAVEED BABUR; | 2024-02-28 |
| 296 | Effectiveness of Virtual Reality in Patients With Symptomatic Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One of the main challenges facing the therapist in the treatment of adhesive capsulitis is to motivate the patient throughout conventional therapy. As noted in a recent review, individuals are more interested in leisure activities rather than performing repetitive tasks during therapy. Virtual reality (VR) is a three-dimensional computer-aided programme built with a system that creates virtual reality movements and generates a high amount of visual and sensory feedback during exercise. As a result, virtual reality (VR) has been used in many medical indications and has been shown to promote adherence to treatment by increasing patient motivation. |
BASAK CIGDEM KARACAY; | 2024-02-28 |
| 297 | Post Marketing Surveillance of Jyseleca Tab. (Filgotinib Maleate) in Korean Subjects PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to collect and evaluate the following information in relation to the safety and the efficacy of Jyseleca tablet (Filgotinib Maleate) 100 milligram (mg) and 200 mg in this post marketing setting: (1) Serious adverse events and adverse drug reactions (2) Unexpected adverse events and adverse drug reactions not reflected in precautions for use (3) Known adverse drug reactions (4) Non-serious adverse events and adverse drug reactions (5) Other safety and effectiveness related information will be evaluated in accordance with the permitted articles under the actual conditions of use in Korea. |
EISAI KOREA | 2024-02-27 |
| 298 | The Feasibility And Efficacy Of A Telerehabilitation Program For People With Knee Osteoarthiritis In Sri Lanka PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: it will be 8 week zoom program of exercises for knee osteo arthritis. participant will be selected according to elegibilty criteria. pre and post measurements will be obtained. then feasibility and efficacy will be assesed. |
UNIVERSITY OF PERADENIYA | 2024-02-22 |
| 299 | Evaluation of The Effect of Different Doses of Ozone Therapy on Pain and Function of Patients With Knee Osteoarthritis Referred to The Sports Medicine Clinic of Hazrat Rasool Akram Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed as a randomized clinical trial that will be conducted in Hazrat Rasool Akram Hospital in Tehran. Patients with knee osteoarthritis were selected based on the study entry criteria and written consent was obtained from them. Then, by random assignment, patients will be divided into three treatment groups: control group (under oxygen gas injection), intervention group 1 (intra-articular injection of ozone with a dose of 20 micrograms) and intervention group 2 (intra-articular injection of ozone with a dose of 40 micrograms). |
AHMAD NAZARI; | 2024-02-20 |
| 300 | Effects of Mulligan Mobilization With Movement (MWM) Technique in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effect of the MWM technique on pain, normal joint movement, proprioception and quality of life in patients with knee osteoarthritis (OA). |
EMINE ATICI; | 2024-02-19 |
| 301 | Efficacy of Pain Neuroscience Education and Physiotherapy in Patients Diagnosed With Spondyloarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Spondyloarthritis, notably ankylosing spondylitis (AS), represents a chronic rheumatic condition typified by persistent back pain and stiffness. It constitutes a substantial portion of diagnoses within rheumatology units and exhibits a higher prevalence among males. Diagnosis relies upon comprehensive clinical evaluation, including patient history, physical examination, and adjunctive radiological assessments, with genetic predisposition, particularly the presence of the HLA-B27 antigen, playing a significant role. Management strategies encompass a multidisciplinary approach, with physiotherapy emerging as a cornerstone therapeutic modality. Various exercise interventions, particularly those supervised by trained professionals, demonstrate efficacy in improving pain, stiffness, and overall functional capacity. Furthermore, … |
CARLOS FERNÁNDEZ-MORALES; | 2024-02-15 |
| 302 | Effect of Mulligan Medial/Lateral Glide With and Without Compression/ Decompression Technique on Pain, Range of Motion and Function on Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Effect of Mulligan Medial/Lateral Glide Techniques with and without Compression-Decompression on Pain, Range of Motion and Function in Patients with Knee Osteoarthritis. This study aims to investigate these effects to develop more effective, non-invasive treatment protocols for improving pain, range of motion and overall function in knee OA |
MUHAMMAD NAVEED BABUR; | 2024-02-15 |
| 303 | The Feasibility and Acceptability of A Plant-Based Diet in People With Rheumatoid Arthritis – A Randomized Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this feasibility study, our primary goal is to assess the practicality of implementing a plant-based food diet intervention for individuals with rheumatoid arthritis (RA). The intervention consists of three key components: 1) Educational materials (videos), 2) Participation in a cooking workshop introducing plant-based meals, complete with recipes, and 3) Daily delivery of plant-based dinner meals over a four-week period. This comprehensive investigation covers the testing of recruitment procedures, randomization, intervention elements, outcome assessments, and participant retention. Adopting a daily plant-based diet involves introducing several new plant-based foods and making adjustments to the existing diets of patients with RA. Consequently, … |
ALLAN LINNEBERG; | 2024-02-15 |
| 304 | Long-term Evaluation of Outcomes of Patients Undergoing Autologous Bone Marrow Concentrate Infiltration Vs. Hyaluronic Acid for The Treatment of Bilateral Knee Osteoarthritis. Prospective Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective observational study for long-term clinical evaluation (minimum 4-year follow-up) in patients treated within the research protocol OA-bi-blind (Double-blind randomized trial on the treatment of bilateral knee osteoarthritis: Autologous bone marrow concentrate VS. hyaluronic acid) |
STEFANO ZAFFAGNINI; | 2024-02-09 |
| 305 | Complementary Treatment With Procaine Periarticular Injections for Pain Reduction and Functional Improvement in Elderly Individuals With Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: § The goal of this clinical trial is to assess the effect of periarticular procaine injections combined with physical therapy on joint pain in individuals 65 and older suffering from osteoarthritis of the hip or the knee. The main question it aims to answer is: Is procaine effective in decreasing joint pain? Researchers will compare procaine injections combined with physical therapy to physical therapy only to evaluate whether or not procaine helps decrease joint pain. Participants will: Undergo procaine periarticular injections and physical therapy Assess their symptoms and pain using scales and tests provided |
SORINA MARIA AURELIAN; | 2024-02-08 |
| 306 | Effect of Overdose Ultrasound on The Articular Cartilage of The Osteoarthritic Knee in Adult Albino Rat: A Histological Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the effect of overdose ultrasound on the articular cartilage of the osteoarthritic knee in adult albino rate. The US is considered the most popular and effective treatment for osteoarthritis as it can penetrate deep tissue reaching internal structures which allow it to be effective for osteoarthritis treatment. Previous researches apply US as a treatment for different cases with different intensity and repetition, but no one has actually proven the frequency of this use or the effect of excess use on cells, … |
SHAHENDA MOHAMED EISSA; | 2024-02-07 |
| 307 | Study on Eating Habits and Association with omic Profiles in Families with A Subject Affected By A Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study is part of a PNRR 2022 project (call Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems, currently awaiting funding response) and represents the continuation of an observational clinical study named TRANSMIC, approved by the pediatric ethics committee of the Tuscany region. TRANSMIC was an integral part of a European research project within the joint programming initiative (JPI), under the HDHL-INTIMIC theme: A Healthy Diet for a Healthy Life, aimed at understanding the cause-effect relationships between diet, gut microbiome, … |
PAOLO LIONETTI; | 2024-02-07 |
| 308 | A Study to Evaluate The Efficacy and Safety of ZILRETTA in Subjects With Glenohumeral Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Objective: To assess the efficacy of ZILRETTA on pain following an intra-articular (IA) injection in subjects with glenohumeral osteoarthritis (OA) relative to normal saline placebo Secondary Objective: * To assess the efficacy of ZILRETTA on pain following an IA injection in subjects with glenohumeral OA relative to triamcinolone acetonide injectable suspension, immediate release (TCA-IR) and normal saline placebo * To assess the safety of ZILRETTA in subjects with glenohumeral OA relative to normal saline placebo and TCA-IR |
ROBERT SORRELL; | 2024-02-05 |
| 309 | Ultrasound-Guided Hydrodilatation With Triamcinolone Acetonide for Adhesive Capsulitis:The Effect of The Rotator Cuff Interval With Posterior Glenohumeral Recess Approaches on The Improvement of Joint Motion and Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to compare the efficacy of ultrasus-guided hydrodilation of Rotator Cuff Interval combined with Posterior Glenohumeral recess approach and hydrodilation of the Rotator cuff Interval alone in Adhesive Capsulitis. |
GENERAL HOSPITAL OF NINGXIA MEDICAL UNIVERSITY | 2024-02-05 |
| 310 | The Impact of Mulligan Squeeze Technique As An Adjunct to Conventional Physiotherapy on Meniscal Derangement in Knee Osteoarthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to find out the effects of Mulligan’s Squeeze technique added as a complementary treatment to the conventional physiotherapy for the management of meniscal derangement in knee osteoarthritis patients. |
IZZA AYUB; PT; | 2024-02-02 |
| 311 | Predictor of Renal Involvement in Rheumatoid Arthritis:Value of Renal Resistive Index PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of resistive index on the renal artery as early predictor factor of renal affection in patients with rheumatoid arthritis. |
FATMA NOMAN MOHAMED ABDELAZIZ; | 2024-02-01 |
| 312 | A Randomized, Open-label, Active-Controlled Phase II Trial to Evaluate The Efficacy and Safety of SSGJ-613 for Prophylaxis Against Acute Gouty Arthritis Flares in Subjects Initiating Urate-Lowering Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the efficacy and safety of recombinant anti-interleukin-1β humanized monoclonal antibody injection in Chinese gout participants Initiating Urate-Lowering Treatment. |
HEJIAN ZOU; | 2024-02-01 |
| 313 | Evaluation of The Effect of Non-Surgical Periodontal Therapy on Serum and Salivary Biomarker Levels in Individuals With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Periodontitis is a common chronic inflammatory disease characterised by the destruction of the soft and hard tissues supporting the tooth, including alveolar bone, periodontal ligament and cementum. Periodontitis has been associated with different host characteristics such as diabetes or neutrophil disorders and environmental factors such as smoking, alcohol consumption and stress. On the other hand, periodontal bacterial infection triggers a systemic immune response that is associated with an increased risk of different disorders such as bacterial pneumonia, cardiovascular disease and autoimmune diseases. Rheumatoid arthritis (RA) is a severe chronic autoimmune disease of unknown etiology, characterised by symmetrical, … |
BURCU KARADUMAN; | 2024-02-01 |
| 314 | Effects of Thrower’s Ten and Routine Physical Therapy on Pain, Range of Motion and Functional Disability in Patients With Shoulder Impingement Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the effects of thrower’s ten and routine physical therapy on pain, range of motion and functional disability in patients with shoulder impingement syndrome |
RABIYA NOOR; | 2024-02-01 |
| 315 | Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases, A Double-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To study the effect of silymarin against methotrexate-induced liver injury in rheumatic diseases including rheumatoid arthritis, psoriatric arthritis and psoriasis |
PHRAMONGKUTKLAO COLLEGE OF MEDICINE AND HOSPITAL | 2024-02-01 |
| 316 | Ultrasound-imaged Muscle Architecture and Muscle Strength in Fibromyalgia and It’s Correlation With Pain, Disease Activity, and Functionality PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to determine whether there is decrease in muscle mass and muscle strength in Fibromyalgia Syndrome (FMS) patients in comparison to controls. And to determine whether these parameters are correlated with clinical ones. Briefly the main questions investigators aims to answer are: – Is there a significant difference in muscle morphology between FMS and controls? – Is there a significant difference in muscle strength between FMS and controls? – Is there a relationship between muscle thickness and pennation angle of the Quadriceps, gastrocnemius medialis, gastrocnemius lateralis and Tibialis anterior muscles and disease activity, … |
DELAL OZTURK; | 2024-02-01 |
| 317 | The GRK2 Inhibitor Paroxetine As A Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid arthritis (RA) is a systemic chronic auto-inflammatory disorder which imposes a remarkable burden of morbidity and mortality on global health. The complex interaction between genetics, environment, and immunological response contribute to RA pathogenesis. Current treatment comprises conventional disease-modifying anti-rheumatic drugs (DMARDs) followed by biological DMARDs, if necessary, to achieve low disease activity or remission. Therapeutics used in RA had limitations in tolerability, access, and response duration and magnitude. Consequently, implementation of safe adjunctive treatment for RA is urgently needed to boost the therapeutic response. |
MOSTAFA BAHAA; | 2024-01-31 |
| 318 | The AMPK Modulator Metformin As A Novel Adjunct to Conventional Therapy in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis (OA) is a chronic, painful disease associated with considerable morbidity, costs and disability. It is estimated that over a third of people aged over 60 have radiographic knee OA2 and over 50% of these with knee OA will go on to have a total knee replacement in their lifetime. At present there are no licensed treatments that alter disease progress and management is primarily concerned with symptom control to retain or improve joint function, although a trial of strontium ranelate showed promising results. |
MOSTAFA BAHAA; | 2024-01-30 |
| 319 | Combined Open And Closed Kinetic Chain Exercises On Static And Dynamic Strength Of Hamstring And Quadriceps In Knee Osteoarthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: study will be conducted at faculty of physical therapy cairo university to investigate the effect of combined kinetic chain exercises on static and dynamic hamstring and quadriceps strength in knee osteoarthritis patients |
HADEER ALI EL SAYAAD; | 2024-01-30 |
| 320 | A Phase 1/2a Randomized, Double-Blind Placebo-controlled Study of Intra-articular Allocetra in Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double blind, randomized,multi-center study to evaluate the safety and efficacy of intra-articular administration of Allocetra compared to placebo in patients with symptomatic knee osteoarthritis. |
ENLIVEX THERAPEUTICS | 2024-01-26 |
| 321 | Defining Stress REsilience And Mindfulness Effects in Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial will test a mindfulness program in individuals with rheumatoid arthritis (RA). The main goals of this pilot study are to: * Assess patient satisfaction with a mindfulness course * Identify barriers to participation in, or completion of, a mindfulness course * Gather initial information to understand how a mindfulness course impacts RA symptoms Participants will: * Complete online questionnaires * Attend two in-person study visits, … |
SARAH L PATTERSON; | 2024-01-26 |
| 322 | A Multicenter, Phase 1b, Double-blind, Placebo-controlled Study to Evaluate The Safety and Tolerability, and The Efficacy of Si-544 in Adults With Psoriasis Vulgaris or Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to investigate the safety and tolerability of si-544. Other objectives are to study the metabolism of si-544 in the body and to assess the effects of si-544 on cells of the body’s immune system (immune cells) that have been chronically activated by the disease. Likewise, the effect of si-544 on inflammatory responses in the body triggered by the disease and other disease symptoms will be investigated. |
SELECTION THERAPEUTICS | 2024-01-22 |
| 323 | ADDITIVE BENEFITS OF KALTENBORN SUSTAINED STRETCH JOINT MOBILIZATION WITH RESISTANCE EXERCISE TRAINING IN KNEE OSTEOARTHRITIS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: to determine the supplementary effects of Kaltenborn sustained stretch mobilization when combined with resistance training in the management of knee osteoarthritis. |
ANAS HAMEED; | 2024-01-20 |
| 324 | Efficacy of Hydrolyzed Collagen and Undenatured Collagen Type II in Alleviating Pain in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized controlled trial Targeted patients who come to receive treatment for osteoarthritis that meets the research indications will be assigned to a random group by the box of 4 randomization method, with a sequence that is randomly generated by a computer. The groups are divided into two groups: Group 1: Patients who have taken 480 mg of hydrolyzed collagen and 20 mg of undenatured type II collagen Group 2: Control patients will take placebo Primary outcome : Pain level |
VARAH YUENYONGVIWAT; | 2024-01-20 |
| 325 | Prevalence of Musculoskeletal Complaints in Nursing Home Residents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the prevalence of joint complaints in nursing home residents with and without dementia. Primary objective: Number of tender or swollen joints. Secondary objectives: 1. Only when it is possible for the nursing home resident to provide us this information: how nursing home residents themselves assess the severity of their joint complaints that day (at that time). If the nursing home resident cannot answer this question (reliably), … |
MARLOES VAN ONNA; | 2024-01-18 |
| 326 | Multicenter, PrOspective, Randomized, Controlled Trial Comparing GenIcular Artery EmbOlization Using Embosphere Microspheres to Corticosteroid INjections for The Treatment of Symptomatic Knee Osteoarthritis: MOTION Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This multicenter, prospective, interventional trial is designed to assess the outcome of subjects with symptomatic knee osteoarthritis (OA) that are randomized to treatment with either genicular artery embolization (GAE) using Embosphere Microspheres or steroid injection over a period of 24 months. |
SANDEEP BAGLA; | 2024-01-16 |
| 327 | The Efficacy of Intra-articular Triamcinolone Acetonide 5mg Vs. 10 Mg Vs. 40 Mg in Patients With Knee Osteoarthritis: A Non-inferiority Randomized Controlled Double-blind Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis of the knee is a common problem that is increasing in prevalence as the population ages. In a knee with osteoarthritis, there is variable damage to the articular cartilage and underlying bone that can cause varying degrees of pain. When pain is bothersome, osteoarthritis is treated to improve functional abilities. One of the most recognized and used treatments is intra-articular cortisone injection. Cortisone is a powerful anti-inflammatory drug that is used to reduce pain. Unfortunately, cortisone can have significant side effects, … |
DIEN HUNG LUONG; | 2024-01-15 |
| 328 | Influence of Honey Phonophoresis on Cartilage Thickness in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is a progressive chronic disease with the loss of articular cartilage. It is now well recognized that the progression of the disease involves erosion of the cartilage, osteochondral inflammatory damage, and bone distortion. Many recent medical procedures provide treatment through improving symptoms through tissue regeneration and restoring homeostasis to local cells. Unlike bone, articular cartilage is rather recalcitrant to regenerate. Honey is a natural material contain 200 distinct chemical compounds in honey including a wide range of phenolic compounds that have antioxidant, bacteriostatic, antimicrobial, … |
MOHAMED MOUSTAFA MOHAMED AHMED; | 2024-01-15 |
| 329 | Bone Marrow Vs Adipose Tissue As A Cell Source for Infiltrative Treatment of Knee Osteoarthritis: Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The MAST-GR study is a randomized controlled interventional trial with parallel treatment arms and 1:1 allocation The primary objective of the study is to compare the safety and efficacy of a single intra-articular infiltration of Bone marrow aspirate concentrate (BMAC) with one of minimally manipulated adipose tissue (MM-AT) so as to determine the most effective cellular product in treating patients with knee osteoarthritis (OA). The secondary objective is to demonstrate whether intra-articular infiltration of BMAC or MM-AT can induce disease-modifying effects in knee OA by imaging and biological assessments on peripheral blood. The tertiary objective of the study is to identify factors that influence the clinical response to treatment (baseline characteristics of patients, biological characteristics of the treated knee, characteristics of cellular products, BMAC and MM-AT). |
LUCA ANDRIOLO; | 2024-01-08 |
| 330 | Investigating The Effects of Mat Pilates Exercises in Patients With Axial Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effectiveness of mat Pilates exercises on spinal mobility, spinal muscle endurance, disease activity, fatigue, emotional well-being, physical performance, and overall quality of life in Psoriatic Arthritis (PsA) patients with axial involvement. |
DENIZ BAYRAKTAR; | 2024-01-08 |
| 331 | A Prospective, Multicenter Clinical Investigation Evaluating The Safety of ABIO3419 in Treating Knee Osteoarthritis: Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is a chronic degenerative joint disease characterized macroscopically by progressive damage of articular cartilage, joint space narrowing, subchondral bone remodelling, joint marginal osteophyte formation and synovitis. It is also characterized by a decrease of the concentration and molecular weight of the hyaluronic acid in the synovial fluid which ultimately leads to poor viscoelastic properties of synovial fluid and induction of proinflammatory pathways. The intra-articular injection of viscosupplementation gel (mainly exogenous hyaluronic acid) represents one of the most used therapeutic strategies to treat osteoarthritis symptoms. Several studies on knee Osteoarthritis, … |
KRISTAPS KNOHENFELDS; | 2024-01-08 |
| 332 | Immediate Effects of High-intensity Laser Therapy on Knee Joint Position Sense and Knee Muscle Strength in Patients with Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare whether HILT versus Sham-HILT is effective to reduce pain, improve knee joint position sense, and knee muscle strength. Participants will undergo a single-session of HILT or Sham-HILT, the measurements of pain, knee joint position sense error, and knee muscle strength will be done at before, immediately after, and 24-hour after the single-session intervention. |
PRASERT SAKULSRIPRASERT; | 2024-01-05 |
| 333 | Comparative Effects of Core Stabilization Exercises Versus Foot-ankle Strengthening Program on Pain, Physical Function and Quality of Life in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis (OA) is also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage. It is most common in the elder population. It results from functional disability and altered knee biomechanics. Risk factors of Knee OA include; older age, genetics and obesity, female gender. The aim of this study is to compare the effects of core stabilization exercises versus foot-ankle strengthening program on pain, physical function and quality of life in patients with knee osteoarthritis. |
ALI RAZA; | 2024-01-04 |
| 334 | Comparative Effect of Radial Shockwave Therapy and Graston Instrument Assisted Soft Tissue Mobilization on Plantar Fasciitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Plantar fasciitis is a common musculoskeletal disorder characterized by inflammation of the plantar fascia, causing heel pain and discomfort. Various treatment modalities have been explored to alleviate symptoms, … |
SABA RAFIQUE; | 2024-01-04 |
| 335 | Intraarticular Gold Microparticles for Hip Osteoarthritis – A 2-year Follow-up Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In a pilot study, we recently showed that intraarticular metallic gold microparticles reduce knee osteoarthritis pain for up to two years and found associated significant proteomic changes in serum and synovial fluid within eight weeks. This study aim to evaluate the outcome after intra-articular injection of gold microparticles for hip osteoarthritis. |
STEN RASMUSSEN; | 2024-01-02 |
| 336 | Comparison of Short-term Effects of Extracorporeal Shock Wave Therapy, Low-level Laser Therapy and Pulsed Electromagnetic Field Therapy in Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 120 patients with Kellgren-Lawrence grade 2-3 knee osteoarthritis will be randomized into four groups: Control group, Extracorporeal shock wave therapy (ESWT) (once a week for 3 sessions), Low-level laser therapy (LLLT) (twice a week for 8 sessions), and Pulsed electromagnetic field therapy (PEMF) (twice a week for 8 sessions), with 30 patients in each group. All participants will be instructed in a daily exercise program, including knee joint range of motion, stretching, and strengthening exercises (3×10 repetitions). Outcome measures, including the Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Short Form-36 (SF-36), … |
BILINÇ DOĞRUÖZ KARATEKIN; | 2024-01-01 |
| 337 | Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty: A Blinded Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Total knee arthroplasty is a surgical treatment which involves replacing the damaged articular cartilage of the knee joint with an artificial prosthetic in end-stage knee osteoarthritis. Although total knee arthroplasties are mostly successful, approximately 1 in 5 patients are unsatisfied with their outcomes with 16-33% of patients of patients experiencing lasting pain following total knee arthroplasty. Multiprofen-CC™ is a compounded topical analgesic currently available to healthcare professionals for prescription in patients experiencing localized musculoskeletal pain. To date there has been no evidence-based guidance generated to evaluate the efficacy of Multiprofen-CC™ in osteoarthritis patients. This study will test, … |
GIUSEPPE VALENTE; | 2024-01-01 |
| 338 | Impact of Personalized Rehabilitation Guidance Based on WeChat Official Accounts Platform on Functional Recovery and Quality of Life of Patients with Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate the impact of personalized rehabilitation guidance based on the WeChat Official Accounts Platform on the functional recovery and quality of life of patients with knee osteoarthritis (KOA).Ninety patients diagnosed with KOA undergoing joint replacement were included via convenient sampling.The patients were randomly divided into an observation group and a control group,with 45 patients in each group.The control group received traditional rehabilitation guidance,while the observation group received personalized rehabilitation guidance through the WeChat Official Accounts Platform in addition to the traditional guidance.Different care plans had varying effects on patients’ scores on the 36-item Short Form Health Survey (SF-36),Visual Analog Scale (VAS),and Lysholm Knee Scoring Scale. |
YAN DONG; | 2024-01-01 |
| 339 | Effects of Haptic Movement Retraining on Osteoarthritis Progression PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading. Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loading. However, this has not been tested in individuals with knee osteoarthritis. In this study, participants will be trained to alter the activation of their gastrocnemius muscle, … |
SCOTT DELP; | 2024-01-01 |
| 340 | Managing Dry Eye in Rheumatoid Arthritis Patients With Dual-Polymer Hydroxypropyl Guar-and Hyaluronic Acid Containing Lubricant Eye Drops PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the efficacy of hydroxypropyl guar-and hyaluronic acid containing lubricant eye drops in rheumatoid arthritis patients . The main question it aims to answer is: • whether adding hydroxypropyl guar-and hyaluronic acid containing lubricant eye drops to steroid-based dry eye therapy improves dry eye symptoms in rheumatoid arthritis patients after 1 month. Participants with rheumatoid arthritis will be treat with SYSTANE™ Hydration Lubricant Eye Drops (1-2 drops 4 times a day) and 0.1% Fluorometholone (1-2 drops 3 times a day) in both eyes for 12 weeks |
CHI-CHIN SUN; | 2024-01-01 |
| 341 | Knee Osteoarthrosis (KOA) in Jordanian Patients: A Phase I Dose-finding Study Using Extracellular Vesicles (EV) for Advanced Stage III and IV KOA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Extracellular vesicles (EV) will be injected in patients diagnosed with Knee osteoarthrosis |
HANAN JAFAR; | 2024-01-01 |
| 342 | Effectiveness of Digital Rehabilitation (SIMPLI.REHAB) in The Arthritis Hand: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the effectiveness of SIMPLI.REHAB, a digital tool employed as an interface for administering occupational rehabilitation programs to patients diagnosed with Rheumatoid and Psoriatic Arthritis. Both of these conditions are inflammatory joint disorders capable of causing significant morphofunctional alterations in the hands, especially in their advanced stages. The introduction of digital technology emerges as a complementary tool when implementing rehabilitation programs. Utilizing a prospective, longitudinal, single-blinded experimental study, … |
EUGÉNIO MOITA GONÇALVES; | 2024-01-01 |
| 343 | The Efficiency of Supervised Exercise Program Versus Personalized Mobile-Based Exercise Program in Patients With Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Juvenile Idiopathic Arthritis (JIA) is a heterogeneous, idiopathic, chronic inflammatory, rheumatic disease that is most common in childhood and is thought to involve immunological mechanisms in its etiopathogenesis. Exercise and physical activity (PA) approaches have an important place in the treatment of childhood rheumatic diseases. These approaches alleviate both the symptoms of children and adolescents’ chronic diseases and complications secondary to pharmacological treatments, and prevent the occurrence of new chronic diseases. However, it is difficult to draw conclusions regarding the effects of exercise types on patients with JIA, … |
AYSE ASENA YEKDANEH; | 2024-01-01 |
| 344 | Role of Lung Ultrasound in Screening for Interstitial Lung Disease in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this observational cross-sectional study is to assess accuracy of Lung Ultrasound to early diagnose ILD among Rheumatoid arthritis patients. Rheumatoid arthritis patients with suggestive history of chest troubles will be evaluated using chest ultrasound and high resolution CT chest to evaluate ability of chest ultrasound to early diagnose ILD among rheumatoid arthritis patients. |
WALEED GAMAL ELDDIN KHALEEL; | 2024-01-01 |
| 345 | Effects of The Otago Exercise Program on Rehabilitation Outcomes of Balance, Strength and Functional Outcomes in Post-Operative Total Knee Replacement Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research is to assess the effects of the Otago Exercise Program on Rehabilitation outcomes of balance strength and functional outcomes of post Total Knee Replacement patients. A randomized controlled trial that will include a total of 44 participants divided into two groups control and experimental. The experimental group will receive the Otago Exercise Program for four weeks, three times per week for forty to forty-five minutes. The control group will receive general TKR protocol for four weeks, three times per week for 30 minutes. Data collected will be analyzed through SPSS 25. |
SARA AABROO; | 2024-01-01 |
| 346 | Effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) Therapy in Rheumatoid Arthritis (RA) Patients With Persistent Pain Despite Inflammation Being Under Control: A Multiple Baseline Single Case Experimental Design Study Across Ten Cases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Around 20% of rheumatoid arthritis (RA) patients have persistent pain, despite having well-controlled disease activity. There is a significant overlap in underlying mechanisms between post-traumatic stress disorder (PTSD) and persistent pain. Eye Movement Desensitization and Reprocessing (EMDR) is a proven effective treatment for PTSD and evidence is growing that it may also be effective for persistent pain. Objective: To assess the feasibility and estimate the effectiveness of EMDR in RA patients with persistent pain despite inflammation being under control. Study design: A multiple-baseline single-case experimental design (SCED) across three time series. Participants will be randomized to one of the three time series. Within the time series the start of the intervention is randomly determined. Four participants will be assigned to the shortest, three to the medium and three to the longest baseline length. The SCED study consists of a baseline phase (A1), intervention phase (B), post-treatment phase (A2), follow-up phase 1 (A3), and follow-up phase 2 (A4). Study population: Subjects are RA patients > 18 years with low disease activity (DAS28<3.2) at >2 measurements over the previous 12 months and concurrent elevated pain scores (NRS-pain>6). Intervention (if applicable): EMDR therapy consists of an intake and eight sessions of 90 minutes in total, performed according to the EMDR standard protocol, conducted by four psychologists, all are level-II trained, under the supervision of an EMDR Europe consultant. EMDR focuses on processing traumatic memories, pain-related memories, and current physical pain. Main study parameters/endpoints: Primary endpoint for effectiveness is the pre-treatment phase A1 to post-treatment phase A2 difference in NRS pain intensity. Feasibility is examined by monitoring recruitment, dropout rates, and treatment satisfaction. Nature and extent of the burden and risks associated with participation, benefit and group relatedness: If the therapy is effective, pain intensity decreases, additional physical complaints of RA decrease and participants experience less discomfort from their pain in daily life. EMDR therapy is an evidence-based treatment for PTSD and the reduction of posttraumatic stress favors the recovery of physical complaints. Participating in the study includes two conversations for inclusion (two times 60 minutes consisting of one telephone conversation and one face-to-face conversation), attending the EMDR therapy intake (one time 90 minutes) and sessions (eight times 90 minutes), and daily registration of complaints (about two minutes per day) via a smartphone application, completing the questionnaires (about 14-28 minutes at six specific time points during the study), and an exit conversation at six months follow up. Daily registration will take 18 to 20 weeks maximum. At the three- and six-month follow-up, participants will be asked to register daily for 14 days. EMDR sessions can be emotionally intense, but never are as challenging as living with unprocessed (traumatic) pain-related memories. There are no risks associated with EMDR therapy. |
HARALD E. VONKEMAN; | 2024-01-01 |
| 347 | The Efficacy of Allogenic Mesenchymal Stem Cells Derived Exosomes in Osteoarthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Present research focuses on the potential of exosomes, which are small vesicles secreted by mesenchymal stem cells (MSCs), as a therapeutic approach for osteoarthritis (OA). OA is a degenerative joint disorder characterized by the destruction of cartilage and loss of extracellular matrix. It’s associated with pro-inflammatory cytokines and increased expression of matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS). MSCs have been explored as a new treatment for OA over the last decade1. It’s suggested that the paracrine secretion of trophic factors, in which exosomes play a crucial role, … |
LEILA DEHGHANI; | 2024-01-01 |
| 348 | Evaluation of Serum Follistatin-Like Protein 1 Levels in Behcet’s Disease and Its Association With Disease Activity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Behçet’s disease (BD) is a multi-system auto inflammatory disorder with vasculitic features. The exact etiological of BD is still obscure, although environmental and genetics factors have been found to be involved in disease pathogenesis.FSTL-1 can act as diagnostic and prognostic biomarkers for Some inflammatory autoimmune diseases including BD. |
SARA FARRAG AHMED MOHAMED; | 2024-01-01 |
| 349 | Comparative Effectiveness of Different Drugs Used to Treat Patients in Rheumatoid Arthritis Saudi Database (RASD) The Primary Objective of This Study Is to Compare The Effectiveness of Different Biological Disease Modifying Antirheumatic Drugs (bDMARDs) and Targeted Synthetic (tsDMARDs) Using DAS-28-CRP and CDAI Scores PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparative effectiveness of different drugs used to treat patients in Rheumatoid Arthritis Saudi database (RASD) Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease-causing significant disability among patients(1). The prevalence rate of RA varies based on the geographical locations, however, several reviews reported a global prevalence rate of 0.5-1.1% with an annual incidence rate of 20-50 cases per 100 000 of the American and North European population(1,2). Of this population, the World Health Organization reports that 50% will not be able to hold a sustainable job after 10 years of diagnosis . In Saudi Arabia, … |
HANI MOHAMMAD ALMOALLIM; | 2023-12-15 |
| 350 | Metacarpophalangeal Joint Prostheses in Hand Surgery. A Retrospective Investigation on Functional Outcome After Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary working hypothesis of this study is whether KeriFlex® metacarpophalangeal joint prostheses provide an equivalent result to Swanson finger joint implants in patients with rheumatoid arthritis or post-traumatic osteoarthritis. Functional status will be measured by Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire no earlier than 1 year after surgery. |
MARKUS BOCK; | 2023-12-15 |
| 351 | The Relationship of Serum Uric Acid With Severity of Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis (Krasnokutsky et al., 2017). The hallmark of OA is the degradation and loss of articular cartilage, although most tissues of the joint become affected, such as bone, synovium, ligaments, menisci (knee), labrum (hip), periarticular fat, and muscle (Englund, 2023).It is believed that there is a pathological link between hyperuricemia and OA Therefore, … |
AYA MOHAMED SABER; | 2023-12-10 |
| 352 | First in Human Study of SakuraBead for Genicular Artery Embolization to Treat Pain Secondary to Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective, single-centre, single-arm, unmasked, First in Human study that aims to evaluate the safety and efficacy of SakuraBead resorbable microspheres in adult patients suffering from pain secondary to knee osteoarthritis. |
CRANNMED | 2023-12-05 |
| 353 | Remote and In-person Supervised Exercise in Patients with Knee Osteoarthritis (RISE-KOA): A Single Blinded, Randomized, Non-inferiority Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Exercise supervision via telehealth resources is an alternative to the in-person modality with similar therapeutic effectiveness across different clinical profiles. Especially in the context of knee osteoarthritis (OA), exercise is recommended by international guidelines. However, it is necessary to elucidate the comparability of remote and in-person supervised exercise effectiveness for these patients. Therefore, the study’s objective is to investigate the responses of a remote compared to the in-person supervised exercise program on patient-reported outcomes measures (PROMs), muscular architecture, … |
CRISTINE LIMA ALBERTON; | 2023-12-04 |
| 354 | Infliximab-Pfizer Biosimilar Post-Marketing Database Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn about the safety of the safety of the study medicine called infliximab for the possible treatment of rheumatoid arthritis (RA), ulcerative colitis (UC, Crohn’s disease, or psoriasis. RA is a kind of joint disease that causes pain and swelling. UC causes inflammation and sores (also called ulcers), in the lining of the rectum and colon. Chron’s disease is a disease that lasts for a long time and causes severe irritation in your digestive tract. Psoriasis is a skin disease that gives you a dry, … |
PFIZER | 2023-12-01 |
| 355 | Performances of DendrisCHIP®OA in Bone and Joint Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bone and joint infections (BJI) with and without prosthetic material (knee, hip and shoulder) are complex to diagnose and treat, justifying the creation of expert centers by the French Ministry of Health (CRIOAc). In case of BJI with material, the diagnosis is based on a set of clinical, bacteriological, cytological and radiological criteria known as the EBJIS 2021 (European Bone & Joint Infections Society) criteria. For septic arthritis, diagnosis is based on bacteriology and cytology. Microbiology remains essential, and the delay of obtention of microbiological results is crucial to adapt the antibiotic treatment. Although, … |
ANNE-LAURE ROUX; | 2023-12-01 |
| 356 | Augmentation of Subscapularis Repair in Total Shoulder Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this research is to compare the images obtained by ultrasound between a standard repair of the subscapularis tissue and after repair with a Biobrace. The secondary purpose is to determine if there are any clinical differences. |
MICHAEL T. FREEHILL; | 2023-12-01 |
| 357 | Effectiveness of A Mobile Telerehabilitation Tool Versus Conventional Treatment in Total Knee Arthroplasty: A Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee arthroplasty is one of the most common surgical procedures, and early rehabilitation is essential for patient recovery, pain modulation and a faster reintegration into daily life activities. However, it has been reported that the percentage of patients who continue rehabilitation for the time required to achieve these outcomes is much lower than those who abandon therapy. This is often due to various factors such as office hours, difficult access to appointments, and sometimes insufficient infrastructure and personnel to meet the demand. Currently, due to the global situation, it is crucial to conduct these rehabilitation processes remotely and virtually, … |
CLAUDIA ARISTIZÁBAL; | 2023-12-01 |
| 358 | Investigation of The Relationship Between Vitamin B12, Folic Acid and 25 OH D Levels and Radiologic Stage in Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the relationship between folic acid, vitamin B12 and 25-OH vitamin D levels and radiographic staging in patients diagnosed with primary gonarthrosis. |
FILIZ YILDIZ AYDIN; | 2023-12-01 |
| 359 | Phonophoresis Versus Low-Level Laser Therapy on Dequervain Tenosynovitis After Delivery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: De Quervain’s tenosynovitis is a frequently encountered pain of the hand and wrist. It results from compression and irritation of the extensor pollicis brevis and abductor pollicis longs tendons as they pass through the first dorsal compartment of the wrist. Patients complain of tenderness and swelling proximal to the radial styloid process, as well as pain in the wrist and on the radial side of the hand. Owing to persistent pain and inflammation, the pinch and grasp strength of the hand is considerably compromised, … |
REHAM ATTIA MOHAMED KHOTAPY; | 2023-12-01 |
| 360 | Anatomic Relationship Of The Popliteal Vessels In Two Types Of Open Wedge High Tibial Osteotomy ( Monoplanar VS Biplanar ) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Aim Is To Study The Anatomic Relationship Of The Popliteal Vesseles In Two Types Of (OWHTO) Techniques (Monoplanar VS Biplanar) Which Provide More Safe Technique To The PV |
ALI AYMAN FAROUK; | 2023-12-01 |
| 361 | Diagnostic Value of SonoElastography in Evaluation of Median Nerve Changes With Rheumatoid Arthritis Patients Without Symptoms of Carpal Tunnel Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the role of ultrasonography and SE in detecting the median nerve changes before progression to CTS in patients with RA. |
MARCO MAGDY WADIE; | 2023-12-01 |
| 362 | Effect of JAK Inhibitor on Bone Erosion Repair in Rheumatoid Arthritis Assessed By HR-pQCT: A Randomized Placebo-controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective To investigate the effect of Janus kinase (JAK) inhibition by baricitinib on erosion healing in rheumatoid arthritis (RA) patients with active disease using high-resolution peripheral quantitative computer tomography(HR-pQCT). Hypothesis JAK inhibitor can lead to healing of existing erosion in RA patients with active disease. Design and subjects This is a 24-week, randomized, placebo-controlled, … |
HO SO; | 2023-12-01 |
| 363 | Prevalence of Subclinical Vertebral Fractures in Rheumatoid Arthritis and Ankylosing Spondylitis in Egyptian Patients and Its Relation to Some Clinical Data PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study of prevalence of subclinical vertebral fractures in Rheumatoid Arthritis and Ankylosing spondylitis |
BASMA ZARIEF NAGEH FAHMY; | 2023-12-01 |
| 364 | The Impact of Therapeutic Alliance on Clinical Outcomes in Patients With Symptomatic Knee Osteoarthritis. A Randomized Clinical Trial Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The therapeutic alliance (TA) is the working relationship or positive social bond between the patient and the therapist. TA is based on collaboration, communication, empathy of the therapist and mutual respect. Fostering an enhanced therapeutic alliance is a low-cost, therapist-dependent strategy that can accompany any clinical intervention. Growing evidence suggests that the TA plays a pivotal role in clinical outcomes in psychotherapy, medicine and physiotherapy interventions for chronic low back pain. On the other hand, therapeutic exercise is an economic, … |
IVÁN ALEJANDRO CUYUL VÁSQUEZ; | 2023-12-01 |
| 365 | Effect of Immersive Virtual Reality Exergaming Program on Physical Fitness, Functional Capacity and Physical Activity In Adolescents Diagnosed With Juvenile Idiopathic Arthritis: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate the effect of home-based exercise program versus personalized IVR exergame (Fit-XR) program on physical fitness, functional capacity and physical activity in adolescents with Juvenile idiopathic arthritis. Patients followed up by four tertiary pediatric rheumatology centers will be included in the project. Two different exercise programs will be applied to the patients by experienced physiotherapists. Fit-XR program will be 25-30 minutes a day and will be applied 2 days a week for 8 weeks under the supervision of a physiotherapist in the clinic. The total points obtained by the participants during the FiT-XR games will be recorded after each training session. In the second group, a personalized multicomponent (balance, strength, agility, endurance) home- based exercise program will be applied according to the physical fitness level of the children. |
NILAY ARMAN; | 2023-12-01 |
| 366 | Estimate Serum Oxytocin Pharmacodynamic Range in The Periphery Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to define the maximum effect oxytocin (naturally occurring hormone that is made in the brain) has on pain from a 5 minute heat probe applied to the skin and to get an estimate for the relationship between the amount of pain relief at different amounts of oxytocin in the blood. This is a study of participants that will receive an intravenous (IV) infusion of oxytocin (naturally occurring hormone that is made in the brain) with blood samples taken thereafter in order to create a formula to describe the concentrations of oxytocin in the blood over time (pharmacokinetics). In this study healthy volunteers and people with knee arthritis so severe that there is a need for a joint replacement are recruited for a one day study. Each study participant will have 2 IV catheters placed (one in each arm). After placement of the IV catheters, 4 different levels of oxytocin will be given by IV infusion. Blood samples will be taken before the infusion begins and after each different level of the infusion. The blood will be drawn through the second IV catheter. The study team will also do some tests to get a rough idea of how oxytocin changes perceptions on the skin and how this relates to the amount of oxytocin in the blood at the same time. The study team will study a painful perception by placing a probe on the skin and heating it to 113 degrees Fahrenheit for 5 minutes. Each study participant will score any pain that is experienced on a 0 to 10 scale. |
JAMES C EISENACH; | 2023-12-01 |
| 367 | A Prospective, Multi-national, Cross-sectional Study on A Risk-factor Guided Approach to Interstitial Lung Disease Screening in Patients With Rheumatoid Arthritis at Higher Risk for ILD Using High Resolution Computed Tomography PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall aim of the study is to develop and validate a Rheumatoid Arthritis-Interstitial Lung Disease (RA-ILD) clinical prediction model (screening tool) based on risk factors to guide screening for ILD in patients with RA using High Resolution Computed Tomography (HRCT). |
BOEHRINGER INGELHEIM | 2023-11-27 |
| 368 | Effects of Blood Flow Restriction Training With Low Intensity Exercises on Pain,Range of Motion and Quality of Life in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to examine the effects of blood flow restriction training(BFRT) with low intensity exercises on pain, range of motion and quality of life in Knee Osteoarthritis. A randomized clinical trial will be conducted at Lahore general hospital. Non-probability convenience sampling will be used, and 36 subjects, age 40-65 years will be randomly allocated into two groups by lottery method after meeting the inclusion criteria. |
IQRA KHAN; | 2023-11-23 |
| 369 | Effects of Kaltenborn Versus Mulligan Techniques on Pain, Range of Motion and Functional Disability in Patients With Rheumatoid Arthritis Of The Wrist PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project was a randomized control trial conducted to check the effects of kaltenborn versus mulligan techniques on pain ,range of motion and functional disability in patients with rheumatoid arthritis of the wrist The inflammatory polyarthritis that primarily affects the tiny joints is a hallmark of rheumatoid arthritis, a chronic autoimmune illness. It is characterized by synovial joint degeneration, joint swelling, and joint discomfort, … |
HAJRA ANWER; | 2023-11-23 |
| 370 | Comparison of Intrinsic Foot Muscle Strengthening and Hip Abductor Strengthening on Pain, Range of Motion, Function, Foot Arches and Knee Alignment in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be Randomized controlled trail, Subject diagnosed with knee osteoarthritis meeting predetermined inclusion and exclusion criteria will be divided into two groups. Pre assessment will be done using pain, ROM, function, foot arches and knee alignment as subjective measurement through KOOS questionnaire, goniometer, 2D frontal plane projection, Berkemann foot prints using ink and paper ,30s chair stand test, … |
MUHAMMAD SANAULLAH; | 2023-11-23 |
| 371 | Effects of Sensory Motor Training Versus Kinesthetic Exercises on Pain, Range of Motion, Proprioception and Quality of Life in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study i will see the effects of kinesthetic exercises and sensory motor training on pain and range of motion in patients with knee OA. |
MUHAMMAD SANAULLAH; | 2023-11-23 |
| 372 | Evaluation of The Efficiency of Propioceptive Study According to Radiological Stages in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: We divided patients with knee osteoarthritis into two groups. Group 1 consisted of stage 1 and stage 2 patients. Group 2 consisted of stage 3 and stage 4 patients. Proprioceptive … |
SIBEL GAYRETLI ATAN; | 2023-11-21 |
| 373 | A Randomized, Multi-center, Double Blind, Parallel Study to Examine The Effect of Lipogems Processed Microfragmented Adipose Tissue in Comparison to Saline for The Treatment of Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effect of a single autologous, intra-articular injection of MFat versus saline injection for the treatment of pain and function associated with K/L grade 2/3 knee Osteoarthritis. Participants will receive an injection of MFat or saline. |
LIPOGEMS INTERNATIONAL SPA | 2023-11-20 |
| 374 | The Role of Synovectomy in Pain Reduction Among Osteoarthritis Patients Following Total Knee Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is the most common joint disease, causing severe pain due to joint inflammation (synovitis). While total knee arthroplasty (TKA) is commonly performed to reduce pain, 20% of patients are dissatisfied with their outcome post-surgery. This dissatisfaction is caused by persistent pain post-TKA due to synovitis that is not routinely removed during surgery. To address this problem, a synovectomy can be performed during TKA, which involves resecting the inflamed layer of tissue lining the joint, called the synovium, and its associated sensory nerve endings. Since the synovium will regenerate in the months post-surgery, … |
BRENT LANTING; | 2023-11-20 |
| 375 | Effect of Combined Mode-Kinetic Chain Exercise With and Without Core Stability Exercises on Pain, Range of Motion, Quality of Life on Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this [type of study: Randomized control trial] is to [ see the effects of Combined Mode Kinetic Chain Exercises along with or without core stability exercises on pain, range of motion and disability ] in [ in patients with Knee Osteoarthritis].The main question it aims to answer is: Wether core stability exercises is effective if performed along with Combined chain kinetic exercises to improves the condition of Knee Osteoarthritis? Group A will receive Core Stability Exercises along with Combined Chain Kinetic Exercises and Group B will receive combined Chain Kinetic Exercises. |
MUHAMMAD SANAULLAH; | 2023-11-20 |
| 376 | Comparative Effect of Non Immersive Virtual Reality Based Training (Xbox Kinect) and Kinetic Chain Exercises in Patient With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is necessary to explore the novel rehabilitation strategies to treat knee osteoarthritis. Although kinetic chain exercises have shown efficacy but there is growing interest in Virtual Reality training using Xbox Kinect because it has the potential to enhance motivation and patient’s adherence to Rehabilitation. The aim of this study is to compare the effectiveness of both interventions and provide a valuable insight to optimize the therapeutic strategies for treating knee osteoarthritis. |
SYED SHAKIL URREHMAN; | 2023-11-16 |
| 377 | Partial Wrist Denervation Versus Self-managed Exercise Therapy in Patients with Wrist Osteoarthritis: A Randomized Controlled Multicenter Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized controlled trial comparing partial wrist denervation to a self-managed exercise therapy program in 140 patients with wrist osteoarthritis. |
ELIN SWÄRD; | 2023-11-15 |
| 378 | Accelerated Rehabilitation Program and Functional Recovery After Direct Anterior Approach for Total Hip Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The causes for total hip arthroplasty (THA) in Taiwan include ischemic necrosis of the femoral head and degenerative osteoarthritis. Contemporary, the surgical approach for total hip replacement mostly adopts the lateral approach. However, the direct anterior approach (DAA) has gained attention gradually due to its characteristics such as muscle preservation, small surgical incision length, and few surgical complications. Nevertheless, literature lacks detailed exploration or long-term follow-up on the recovery of physical functions related to fall occurrence after this type of surgery. It limits the establishment and design of suitable post-operative rehabilitation plans. Therefore, … |
HSIU-CHEN LIN; | 2023-11-14 |
| 379 | Investıgatıon Of The Effect Of Traınıng And Counselıng Provıded By Tele Nursıng Servıce After Total Knee Prosthesıs On Post-Operatıve Qualıty Of Lıfe And Complıcatıons PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine the effect of education and consultancy provided via telenursing service after total knee arthroplasty on postoperative quality of life and some complications. |
GÜLŞAH BEKTAŞ; | 2023-11-13 |
| 380 | Effect of Ultrasound With Simultaneous Hyaluronate Injection on Risk of Fall in Geriatric Women With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: For many years’ physiotherapists have been using ultrasound in treatment of knee osteoarthritis especially in geriatrics (people aged above 65 years) for its known therapeutic effect in relieving pain and improving knee function. Hyaluronan is used to treat osteoarthritis of the knee. Such treatments, called viscosupplementation, are administered as a course of injections into the knee joint, and are believed to supplement the viscosity of the joint fluid, thereby lubricating the joint, cushioning the joint, … |
HEND REDA SAKR; | 2023-11-11 |
| 381 | Safety and Efficacy of SWK002 in Patients with D2T-Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label, single-site, dose-escalation study in up to 18 participants with refractory rheumatoid arthritis. This study aims to evaluate the safety and efficacy of the treatment with Anti-CD19 CART. |
THE FIRST AFFILIATED HOSPITAL OF UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA | 2023-11-09 |
| 382 | A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-ranging, Efficacy and Safety Study of SAR441566 Plus Methotrexate in Adults With ModeratetoSevere Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a parallel group, Phase 2, randomized, double-blind, placebo controlled, 5-arm, international, multicenter, 12-week proof of concept, dose finding study. It is designed to assess efficacy and safety of treatment with SAR441566 for 12 weeks. It will be conducted in male and female adult participants with moderate-to-severe rheumatoid arthritis (RA) not adequately controlled on methotrexate (MTX) and biologic/targeted synthetic disease modifying anti-rheumatic drug (DMARD) naive. Study treatment includes investigational medicinal product (IMP: SAR441566 or placebo) added-on to a background therapy of MTX. Study details include a run-in period (4 to 6 weeks) before randomization to determine eligibility, … |
SANOFI | 2023-11-07 |
| 383 | Incidence of Persistent Pain After Knee Arthroplasty: A Nationwide Cross-sectional Survey Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a nationwide cross-sectional survey on pain and satisfaction after knee arthroplasty (KA). Please find the full protocol uploaded at ClinicalTrials.gov The goal of this observational study is to study pain and satisfaction in patients operated with knee arthroplasty. The main question it aims to answer are: – What is the incidence of persistent postsurgical pain in unselected knee arthroplasty patients – What is the level of satisfaction in unselected knee arthroplasty patients? Participants will be asked to answer a 22-item questionnaire. |
JENS LAIGAARD; | 2023-11-01 |
| 384 | The Impact of Genicular Nerves Chemical Neurolysis on The Quality of Life of Patients With Advanced Knee Osteoarthritis. A Randomized, Double-blinded, Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Genicular nerves chemical neurolysis in advanced osteoarthritis of the knee joint. |
POZNAN UNIVERSITY OF MEDICAL SCIENCES | 2023-11-01 |
| 385 | Effectiveness of Biologics on Synovitis and Enthesitis Using Musculoskeletal Ultrasound Assessment in Subclinical Psoriatic Arthritis: A 12-week Observational Real-world Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriatic arthritis (PsA) is one of the most common comorbidities in patients with psoriasis (PsO). Current research suggests that the progression from PsO to PsA can be divided into five stages of the disease: PsO, preclinical PsA, subclinical PsA, prodromal PsA, and clinical PsA. Subclinical PsA refers to psoriasis participants who do not exhibit any clinical symptoms of arthritis but show evidence of synovio-enthesitis on ultrasound (US). However, there is currently no definitive biomarker that can accurately predict the progression from PsO to PsA. Synovitis and enthesitis are considered important features of PsA. Musculoskeletal ultrasound, … |
CHAO JI; | 2023-11-01 |
| 386 | The Impact of The Pericapsular Nerve Group Block (PENG) Chemical Neurolysis on The Quality of Life of Patients With Advanced Hip Osteoarthritis. A Randomized, Prospective Double-blinded Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PENG neurolysis in advanced osteoarthritis of the hip joint. |
POZNAN UNIVERSITY OF MEDICAL SCIENCES | 2023-11-01 |
| 387 | Frequency of Sacroiliitis in Inflammatory Bowel Disease Patients Using MRI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. to determine the overall frequency of Inflammatory sacroiliitis among patients with Inflammatory bowel disease using magnetic resonance imaging 2. identify the association of sacroliitis in IBD patients clinical and laboratory markers |
MAGY WAGEEH ABDELMALAK; | 2023-11-01 |
| 388 | Effectiveness of Knee Sync Partner and Strengthening Exercises Versus Strengthening Exercises in Knee Osteoarthritis. A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study explores the effectiveness of a novel treatment approach for knee osteoarthritis (OA) by comparing the combined use of a new device, Knee Sync Partner, which provides electrical knee traction with stimulation and strengthening exercises, to traditional strengthening exercises alone. Knee osteoarthritis is a leading cause of chronic pain and disability worldwide, significantly impacting the quality of life for many individuals, especially with the growing elderly population. |
MUHAMMAD NAVEED BABUR; | 2023-11-01 |
| 389 | Effects of Retro-walking in Knee OA Along With Conventional Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis is degenerative joint disease that cause deterioration of the articular cartilage and neighboring tissue and lead to osteophyte formation, weakening of surrounding muscles, ligamentous laxity and inflammation of synovium. Diagnosis can be made based on history and clinical features and risk factors including age, sex, body mass index , absence of whole leg pain, fixed flexion deformity, absence of traumatic event, restricted flexion range of motion, pain in descending stairs, … |
MARIA KHALID; | 2023-11-01 |
| 390 | Comparison of Hip Strengthening Exercises and Core Stability Exercises in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee Osteoarthritis is a chronic degenerative joint disease with complex etiology that results in loss of normal joint function due to damage to the articular cartilage. It is characterized by pain, swelling, … |
RASHID HAFEEZ NASIR; | 2023-11-01 |
| 391 | Impact of Electromagnetic Field Therapy on Pain Severity and Functional Disability in Patients With Mechanical Back Pain: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the impact of electromagnetic field therapy on pain severity and functional disability in mechanical back pain patients suffering from myofascial trigger points. |
DOAA AYOUB ELIMY MOHAMMED; | 2023-11-01 |
| 392 | The Effects of Aerobic Exercise and Active Video Games As Adjuncts to Conventional Physiotherapy on Pain, Functional Capacity, and Balance in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial was conducted by the CONSORT guidelines for non-pharmacological treatments. Participants were randomly assigned to control, gaming, or aerobic groups using the closed-envelope randomization method. All groups received conventional physiotherapy for 8 weeks. In addition, the gaming group played active video games 3 days per week, while the aerobic group engaged in cycling-based aerobic exercise (20 minutes per session) 3 days per week. The control group received only conventional physiotherapy and continued their daily activities. Evaluations were performed by the same assessor at the baseline and after eight weeks. |
SERKAN USGU; | 2023-11-01 |
| 393 | Clinical Study Evaluating The Effect of Carvedilol in Patients With Active Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims at investigating the possible efficacy and safety of carvedilol as an adjunctive therapy in patients with active rheumatoid arthritis and hypertension. |
YOMNA ABDELRAFEA AHMED; | 2023-11-01 |
| 394 | A Prospective, Randomized, Clinical Trial to Evaluate The Safety and Efficacy of AMT-RegeneraActiva in The Management of Knee Osteoarthritis (OA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare in 60 patients suffering for Knee OA to demonstrate that AMT-RegeneraActiva is able to speed up the improvement process of knee osteoarthritis (OA) compared to Sodium Hyaluronate Participants will [describe the main tasks participants will be asked to do, treatments they’ll be given and use bullets if it is more than 2 items]. Researchers will compare 2 Groups to see to demonstrate that AMT-RegeneraActiva is able to speed up the improvement process of knee osteoarthritis (OA) compared to Sodium Hyaluronate to pain management and improvement of functionality. |
VINCENZO SALINI; | 2023-11-01 |
| 395 | An Exploratory Clinical Study to Investigate The Effect of AutoSTEM-OA and AlloSTEM-OA in Participants With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A phase 1 exploratory clinical study to investigate safety, tolerance and efficacy of a single intra-articular injection of autoSTEM-OA or alloSTEM-OA in participants with mild to moderate knee osteoarthritis |
STEMMEDICAL | 2023-11-01 |
| 396 | Balance, Walking Speed, Quadriceps Femoris Muscle Strength and Quality of Life in Falling and Non-falling Individuals With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A descriptive study evaluating balance, gait speed, Quadriceps Femoris muscle strength and quality of life in individuals with Chronic obstructive pulmonary disease (COPD) who fell and did not fall. |
MERAL SERTEL; | 2023-10-30 |
| 397 | A Single Arm, Single Center, Open Label , Pilot Clinical Study to Evaluate The Efficacy and Safety of Transcatheter Arterial Micro Embolization (TAME) Using Nexsphere F in Patients With Knee Degenerative Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Among knee degenerative osteoarthritis patients aged 50 or older, it will prove the therapeutic effect and safety of Nexsphere-F embolization for patients who need additional treatment because pain is not controlled even if conventional treatments are taken. |
HYUCKMIN KWON; | 2023-10-23 |
| 398 | Randomized Crossover Diet Study Comparing Impact of Mediterranean Diet to Western Diet on Fatigue in Autoimmune Hepatitis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, proof-of-concept pilot study which uses a cross-over design to compare two dietary interventions/treatments: Western Diet (WD) vs Mediterranean (MD) and impact on quality-of-life parameters in AIH. Participants will receive both treatments through two phases and will be divided into two groups. |
CRAIG LAMMERT; | 2023-10-23 |
| 399 | The Effect of RF Genicular Nerve Block Applied in The Preoperative Period on Fast-track Total Knee Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In our study, investigators plan to compare the preoperative RF and genicular nerve ablation approach in patients who underwent TKA(Total Knee Arthroplasty) using the Fast-Track protocol in terms of meeting postoperative pain, function and early discharge criteria. |
HARUN RESIT GUNGOR; | 2023-10-19 |
| 400 | Post-Market Clinical Follow Up for Total Knee Arthroplasty System Madison PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: MADISON Total Knee Prosthesis is intended to be used for total knee arthroplasty to reduce pain and restore joint mobility of the knee. Clinical data for MADISON Total Knee Prosthesis available are not deemed sufficient to support performance and benefits claimed on the whole lifetime of the product. Thus, in order to maintain compliance with the EU regulation (2017/745) related to medical devices and following ISO 14/155:2020, SERF has set up post-market clinical follow-up study (PMCF) to confirm safety and performance of Total Knee Arthroplasty system MADISON. This study is designed to cover the expected 15-years follow-up, … |
SOCIETE DETUDE DE RECHERCHE ET DE FABRICATION | 2023-10-17 |
| 401 | Assessment of Fatigue in Psoriatic Arthritis and Cutaneous Psoriasis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Psoriatic arthritis is characterized with pain, swelling and joint stiffness. These are inflammatory reactions against tendons, ligaments and joints associated with fatigue. In France, almost 93.000 people are affected by psoriatic arthritis and the main symptoms appear between 30 and 50 years old. Psoriatic arthritis may be due to a genetic predisposition involving the HLA B27 gene, or to environmental factors such as stress, physical or psychological trauma, or infection. Obesity, type 2 diabetes and hypertension can also be factors associated with the onset of psoriatic arthritis. Cutaneous psoriasis is a non-contagious chronic inflammatory skin disease, … |
CARINA MIHU; | 2023-10-16 |
| 402 | Effect of Metformin As Add-on Therapy to Ibuprofen on Disease Activity in Knee Osteoarthritis Patients: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized, double blind, placebo-controlled clinical trial is to learn about, the effect of metformin compared with placebo-controlled group on disease activity and interleukin-6 level in patients with knee osteoarthritis.The main question it aims to answer is:Is Metformin as add-on therapy more effective in reducing disease activity in Ibuprofen-treated patients with grade II-III knee osteoarthritis? Half of Participants will receive metformin with standard of care(ibuprofen and rabeprazole) while other half placebo and standard of care (ibuprofen and rabeprazole). |
DELOWAR HOSSAIN; | 2023-10-15 |
| 403 | Comparison of The Effectiveness of Physical Therapy With Ultrasound-Guided Radiofrequency Ablation of The Genicular Nerve in Patients With Chronic Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to compare the effects of conventional physiotherapy methods with ultrasound-guided radiofrequency ablation of the genicular nerve on pain and functional status in patients with stage 2-3 chronic knee osteoarthritis. |
MERVE ÇAKIR; | 2023-10-15 |
| 404 | Investigating Orthobiologics After Platelet-Rich Plasma and Photobiomodulation Treatment of Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research assesses the effects that Photobiomodulation Therapy (PBMT) has on Intra-articular administered Plasma-Rich Platelet (PRP) injections for Knee Osteoarthritis (KOA) treatment through evaluations of synovial and serum inflammatory and reparative biomarkers. A comparison of Physical Therapy (PT) vs PT + PRP vs PT + PBMT vs PT + PRP + PBMT for KOA treatment is made. The relationship between self-reported pain and functionality and treatment mechanisms is analyzed along with an analysis of the intersectionality between participant self-reported pain and functionality and medicine markers across treatment groups. These aims seek to inform current treatment practices in treating KOA and returning Active-Duty Service Members to duty readiness. |
SCOTT P GROGAN; | 2023-10-13 |
| 405 | Comparison of Integrated Neuromuscular Inhibition Technique and Dry Needling on Trigger Points in Patient With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to compare the effects of Integrated Neuromuscular Inhibition Technique and Dry Needling on Functional Disability, Pain and Range of Motion. A randomized control trial will be conducted at Wah General Hospital Taxila. The sample size is 36 calculated through G-Power but I recruited 50. The participants were divided into two interventional groups each having 18 participants. Tools used in this study are Goniometer, NPRS, WOMAC, and Self structured Questionnaire. Data will be collected before and immediately after the application of interventions. Data will be analyzed through SPSS. |
LAL GUL KHAN; | 2023-10-12 |
| 406 | An Open-Label Single-Arm Phase I/IIa Study to Evaluate The Safety of Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product StromaForte for The Treatment of Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This open-label, single-arm, phase I/II study in mild-to-moderate stage knee osteoarthritis patients is designed to assess the safety and tolerability of intraarticular human allogeneic bone marrow-derived mesenchymal stromal cell product StromaForte. 12 male and/or female patients aged over 18 years will be enrolled. The main questions it aims to answer are: To assess the safety and tolerability of StromaForte within 24 hours, 4 days ,28 days, 84, … |
FAHTI YOUSEF; | 2023-10-12 |
| 407 | Prospective, Multicenter, Randomized Single-blind Study on The Interest of Capsular Repair in The Latarjet Operation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the occurrence of osteoarthritis (YES/NO) by radiography. |
GCS RAMSAY SANTÉ POUR L’ENSEIGNEMENT ET LA RECHERCHE | 2023-10-11 |
| 408 | Invastigation of The Relationship Between Early Quadriceps Arthrogenic Muscle Inhibition and Functional Recovery After Total Knee Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Total knee arthroplasty (TKA) surgery is a common procedure performed to reduce pain, improve function, and enhance the quality of life in patients with end-stage knee osteoarthritis. As with other knee-related injuries and surgeries, TKA surgery can lead to inhibition of the quadriceps muscle, resulting in a decrease in the muscle’s capacity to generate maximum voluntary force. This issue can negatively affect post-injury rehabilitation and function. The long-term persistent neuromuscular muscle inhibition in the quadriceps, one of the most important anti-gravity muscles in our body, leads to muscle atrophy and strength loss, … |
SIBEL BOZGEYIK; | 2023-10-10 |
| 409 | Comparative Analysis of Aqueous Humor Adipokines in Patients With Glaucoma and Healthy Controls Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to observe whether there are differences in adipokines in the aqueous humor between patients with primary open-angle glaucoma (POAG) and healthy controls |
CHUN ZHANG; | 2023-10-08 |
| 410 | Determining The Impact of A New Physiotherapist-Led Primary Care Model for Hip and Knee Pain – A Pilot Cluster Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot cluster randomized controlled trial to to evaluate the individual and health system impacts of implementing a new physiotherapist-led primary care model for hip and knee pain in Canada. |
JORDAN MILLER; | 2023-10-02 |
| 411 | A Multicenter, Randomized Open-Label Study to Assess The Efficacy, Safety, and Pharmacokinetics of Upadacitinib With A Tocilizumab Reference Arm in Subjects From 1 Year to Less Than 18 Years Old With Active Systemic Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Juvenile Idiopathic Arthritis (JIA) is the most common type of arthritis that affects children. The term idiopathic means of unknown origin. It is a chronic (long-lasting) disease that causes swelling, warmth, and pain of one or more small joints. Systemic JIA ia a rare and serious form of JIA. Systemic means it may affect not only the joints but other parts of the body, including the liver, … |
ABBVIE | 2023-10-02 |
| 412 | Comparison of The Effectiveness of Ultrasound-Guided Perimeniscal Steroid and Dextrose Injections in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: The primary goal of treating knee osteoarthritis is to reduce pain and improve the patient’s quality of life. Medial meniscal extrusion is a condition that is linked to pain and disability in knee osteoarthritis and can be identified through ultrasound. For patients with medial meniscal extrusion, perimeniscal corticosteroid injection has been shown to be a helpful addition to primary treatment for moderate to severe pain relief. Dextrose prolotherapy has also been found to provide periarticular benefits for knee osteoarthritis. This study aims to compare the effectiveness of ultrasound-guided perimeniscal corticosteroid and perimeniscal dextrose injections in patients with osteoarthritis, … |
GAMZE GUL GULEC; | 2023-10-02 |
| 413 | Evidence Based Training Program Combined With Nutrition Therapy for Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to evaluate the effects of an evidence-based training program in combination with an antiinflammatory dietetic intervention on quality of life for patients with knee osteoarthritis |
ST PÖLTEN UNIVERSITY OF APPLIED SCIENCES | 2023-10-02 |
| 414 | Effect of Proprioceptive Exercises on Joint Pain and Quality of Life Among Geriatric Patients With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis, the disease of knee joint pain caused by joint degeneration, it is the commonest joint disease and had a negative effect on geriatric patients’ quality of life (QoL). Proprioceptive exercise and isometric exercise have been recommended as suitable for reducing joint pain and improvement of quality of life in the geriatric patients. |
AML HAMDI MAHMOUD; | 2023-10-01 |
| 415 | Comparison of Infection Rate Between Vancomycin and Gentamycin for Intraoperative Presoaking of Graft in Primary Anterior Cruciate Ligament Reconstruction ( Randomized Controlled Trial ) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to compare the efficacy of Vancomycin versus Gentamycin , in reducing infection rates following Anterior Cruciate Ligament Reconstruction . |
MINA ANWER TAWFEK; | 2023-10-01 |
| 416 | Corticosteroid Vs Platelet-Rich Plasma Intra-articular Injections in The Treatment of Knee Osteoarthritis in Patients Fifty Years and Older: A Look at Pain and Functional Outcomes at A Single Institution PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will explore the effectiveness of intra-articular knee injections in patients with osteoarthritis by comparing Corticosteroid (triamcinolone) vs Platelet Rich Plasma (PRP). This study is a randomized controlled trial with a sample size of one hundred and sixty patients (160). Patients would be recruited via new referrals and follow-up appointments in the Orthopaedic clinic at the UHWI (University Hospital of the West Indies) with knee osteoarthritis. The aim of the study is to: 1. To determine if platelet-rich plasma injections are better at improving functional outcomes in the knee using Western Ontario and McMaster Universities Arthritis Index (WOMAC) when compared to intraarticular steroids. 2. To identify adverse reactions related to these injections |
WAYNE PALMER; | 2023-10-01 |
| 417 | A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Determine The Efficacy, Safety, and Dosing of TG-C in Adult Subjects With Symptomatic Early Hip Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Determine the Efficacy, Safety, and Dosing of TG-C in Adult Subjects with Symptomatic Early Hip Osteoarthritis. TG-C will be administered to the target hip by a single ultrasound (or fluoroscopy)-guided, intra-articular injection with image capture showing correct injection of study drug into the femoroacetabular joint. Patients will be followed for 12 months for safety and efficacy. |
KOLON TISSUEGENE | 2023-10-01 |
| 418 | Efficacy and Safety of Oral L-Arginine for Pain Relief in Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine the pain-relief efficacy and safety of L-arginine in knee OA patients. |
GUANGHUA LEI; | 2023-10-01 |
| 419 | Collection of CT Images to Evaluate Bone Quality Before Total Shoulder Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to evaluate the preoperative bone quality assessment based on CT to later establish a scale for the decision of stemless shoulder arthroplasty. |
ZIMMER BIOMET | 2023-10-01 |
| 420 | A Phase I, Open Label, Single Arm, Multiple Center, Dose Escalation Clinical Trial to Evaluate The Safety, Tolerability and Efficacy of Human Induced Pluripotent Stem Cell Derived Mesenchymal Stromal Cells (NCR100) Injection in The Treatment of Subjects With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It is a dose-escalating, open label study in adult KOA subjects. |
CHANGQING ZHANG; | 2023-10-01 |
| 421 | Changes in Postural Stability and Balance Confidence in People After Elective Unilateral Total Hip Arthroplasty for Osteoarthritis: A Prospective Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Total hip arthroplasty (THA) is a common surgery that eases pain, restores functional movement, and improves the overall quality of life in people with severe hip osteoarthritis (OA). Unfortunately, problems with postural stability, commonly known as balance, are still noticed in people even years after the surgery. These postural stability problems typically result in falls. The aim of the proposed study is to investigate how THA surgery affects a person’s overall quality of life, both physically and psychologically, … |
BRENT LANTING; | 2023-10-01 |
| 422 | An Evaluator-blinded Randomized Controlled Trial Study of The Effect of Anti-inflammatory Diet in Subjects With Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites. |
MONICA GUMA; | 2023-10-01 |
| 423 | A Multicenter, Randomized, Single Blind, Positive Drug and Placebo Parallel Controlled Phase II Clinical Trial to Evaluate The Efficacy and Safety of HRF2105patch in Relieving Pain of Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being conducted to evaluate the efficacy, and safety of HRF2105patch in relieving pain of Osteoarthritis. |
JIANGSU HENGRUI MEDICINE | 2023-10-01 |
| 424 | Role of Tele-rehabilitation in Elderly Women With Locomotor Disabilities Due to Knee Osteo Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is the most common degenerative joint disease with an inflammatory component that starts from the matrix of the articular cartilage. Females are affected more than males and they have marked locomotor disabilities. Moreover, OA patients suffer from a range of extra-articular symptoms which also leads to functional impairment and disability such as fatigue, depression, anxiety, fear of movement, physical inactivity, … |
GOPAL NAMBI; | 2023-10-01 |
| 425 | A Randomized Controlled Trial Comparing The Efficacy of A Three-Point Versus A Six-Point Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare three-point and six-point Genicular Nerve Radiofrequency Ablation (GNRFA) in adults with chronic knee osteoarthritis (KOA). The main question it aims to answer is whether six- target GNRFA technique is more efficacious than standard three-target GNRFA technique in managing the pain and function of KOA. Consented patients who respond to a diagnostic block will be randomly assigned to either three-point or six-point GNRFA. Researchers will compare pain and function in these two groups. |
MCMASTER UNIVERSITY | 2023-10-01 |
| 426 | Comparison of The Effectiveness of Pulsed Radiofrequency Therapy and Canal Adductor Blockade for Chronic Pain and Functioning in Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is intended to prove the efficacy and safety of ultrasound-guided pulsed radiofrequency therapy on adductor canal nerves by patients with Knee osteoarthritis. |
MENSUR SALIHOVIC; | 2023-09-30 |
| 427 | A Multicenter, Randomized, Placebo-Controlled Phase 1b Study to Evaluate The Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of Multiple Ascending Doses of GS-0272 in Adult Participants With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goals of this clinical study are to learn more about the study drug, GS-0272, and its safety and tolerability following multiple doses in participants with rheumatoid arthritis (RA). The primary objectives of this study are to assess the safety and tolerability of multiple ascending doses of GS-0272 and to characterize the pharmacokinetics of GS-0272 following multiple doses of GS-0272, in participants with RA. |
GILEAD SCIENCES | 2023-09-28 |
| 428 | The Effect of Adding Instrumented Hip Concentric Abductor Strengthening Exercise to Instrumented Knee Flexor-Extensor Concentric Strengthening Exercise on Pain, Function, Physical Performance, and Quality of Life in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to investigate the effectiveness of adding hip device-assisted concentric abductor strengthening (HDACAS) program to knee device-assisted concentric flexor-extensor strengthening (KDACFES) program on pain, function, physical performance, quality of life and gait parameters in patients with knee osteoarthritis (OA). |
HASAN HÜSEYIN GÖKPINAR; | 2023-09-20 |
| 429 | Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis: A Randomized Controlled Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this pilot randomized trial is to obtain necessary prerequisite data to conduct a randomized controlled intervention to test the effect of vitamin K supplementation on knee osteoarthritis progression and related functional decline. To address critical parameters required to design this larger RCT, we will conduct a double-blind, 2-armed, parallel-group intervention study, with a placebo run-in, in which 50 adults with mild to moderate knee OA and low baseline vitamin K status will be randomly assigned to 1 mg phylloquinone/day or matching placebo, and treated for 6 months. Specifically, … |
SARAH BOOTH; | 2023-09-20 |
| 430 | Cultural Adaptation and Turkish Version of The Worry About Pain Questionnaire in Individuals With Musculoskeletal Pain: Reliability and Validity Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pain is one of the main complaints that causes people to apply to health institutions. Pain is seen as a passive warning signal of an underlying disease process; When it becomes chronic, it is considered a disease on its own. Pain that persists longer than the expected recovery time is defined as chronic pain. Pain is associated with a number of psychological, physical, and social factors(6). Clinical observations report that various psychological problems, especially anxiety, and depression, accompany chronic pain, and the long-term persistence of pain significantly impacts a patient’s quality of life. Chronic musculoskeletal pain causes fatigue, sleep disruption, … |
KUBRA KOCE; | 2023-09-20 |
| 431 | Healthy Body & Mind Program: A Pilot Randomised Controlled Trial to Improve Quality of Life, Reduce Pain, and Reduce Dementia Risk in People Living With Cognitive Decline and Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot randomised clinical trial is to compare a 12-week Healthy Body & Mind Program to usual care in older adults living with cognitive decline and osteoarthritis. The main questions it aims to answer are: – Does the Healthy Body & Mind Program improve health-related quality of life in older adults living with cognitive decline and osteoarthritis (pre/post and intervention/control)? – Does the Healthy Body & Mind Program improve other health outcomes (cognition, pain, anxiety/depression, … |
CLAIRE BURLEY; | 2023-09-18 |
| 432 | Investigation of The Effects of Percussion Massage Therapy After Anterior Cruciate Ligament Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Over the past decade, vibration therapy has gained popularity. This treatment involves the transmission of vibration either through whole-body vibration (WBV) platforms or by applying local vibration (LV) directly to the muscles or tendons. In the context of ACLR (anterior cruciate ligament reconstruction), it has been reported that a single session of either WBV or LV, applied while patients maintain a squatting position, acutely improves the strength of the Quadriceps muscle when applied 50 months post-surgery, … |
BURAK MENEK; | 2023-09-15 |
| 433 | Magnetic Field Therapy Versus Transcutaneous Electrical Nerve-stimulation in Knee Osteoarthritis: A Head-to-head Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The effectiveness of PEMF in improving physical function among Osteoarthritic (OA) patients remains a topic of debate, leading to the American College of Rheumatology not yet endorsing its use in OA treatment. Therefore, it’s essential to investigate PEMF therapy’s efficacy in alleviating joint pain, stiffness, and enhancing physical function in knee OA patients Our study objectives were to evaluate the effectiveness and safety of PEMF therapy and to compare its efficacy with TENS in knee OA management. |
RAZGALLAH EMNA; | 2023-09-15 |
| 434 | Extended Hip Ultrasound As Anew Protocol for Septic Hip in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To establish a new protocol in order to increase ultrasound diagnostic accuracy of pediatrics presented with signs of septic hip . |
DALIA KHALED MOSTAFA MOHAMED; | 2023-09-15 |
| 435 | A Multicentre Randomized, Double-blind, Placebo Controlled, Dose-finding, Phase 2 Study (MARS-17) of GSK3858279 in Adult Participants With Moderate to Severe Pain Due to Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is dose-finding study of GSK3858279 in participants with moderate to severe knee osteoarthritis pain. The purpose of this study is to investigate and provide the data necessary to select the optimal effective and safe dose(s) of GSK3858279. |
GLAXOSMITHKLINE | 2023-09-13 |
| 436 | A Multicenter, Postmarket Surveillance Study of Subjects With The Canary CanturioTM Te Tibial Extension PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this prospective observational cohort study are to evaluate the safety, reliability, reproducibility, and accuracy of the Canary canturioTM te post-TKA. |
CHARLES HANBY; | 2023-09-12 |
| 437 | Effect of Retrowalking Program Versus Whole Body Vibration on Quadriceps Muscle Torque in Patients With Chronic Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis is one of the most common degenerative joint disease that affects approximately more than 300 million people worldwide |
MARWA GA AMR; | 2023-09-11 |
| 438 | A Phase 3 Prospective, Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate The Efficacy of Amniotic Suspension Allograft (ASA) in Patients with Osteoarthritis of The Knee PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee. |
ORGANOGENESIS | 2023-09-06 |
| 439 | Evaluation of The Relationship Between The Architecture of The Quadriceps, Tibialis Anterior and Gastrocnemius Muscles and Muscle Strength in Female Gonarthrosis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this cross-sectional study is to evaluate muscle architecture changes and it’s effect on muscle strength in female patients with gonarthrosis.Main questions are: – Is there any correlation between muscle strength and muscle thickness, pennation angle fiber length? – Is there any muscle architecture difference in gonarthrosis and is it effecting the muscle strength? The investigators will enroll patients with unilateral gonarthrosis so that investigators can compare the changes within osteoarthritic and healthy knee with the same physical activity levels. |
BEZMIALEM VAKIF UNIVERSITY | 2023-09-05 |
| 440 | Exploring Biomechanics and Clinical Outcomes in Responders and Non-Responders to Physical Therapy Management for Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis is a degenerative joint disease that affects many older adults. However, not all patients see improvements as a result of physical therapy management; therefore, a better understanding of biomechanics and assessment of clinical outcomes between responders and non-responders is required. The included participants will be provided with informed consent and an explanation of the study procedure before enrolling in data collection. The data collection will be arranged in the same order. Practice trials will be provided before the start of data collection. The data collection will consist of standardized questionnaires, assessments, and tests commonly used in clinics. |
KOMSAK SINSURIN; | 2023-09-05 |
| 441 | Efficacy and Safety of Melatonin for Pain Relief in Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: By recruiting knee osteoarthritis patients and treating them with melatonin, this study aims to determine the efficacy and safety of melatonin in alleviating pain in this patient population. |
CHAO ZENG; | 2023-09-01 |
| 442 | Therapeutic Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis and Periarticular Tissue Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury. |
XIJING HOSPITAL | 2023-09-01 |
| 443 | Evaluation of Some Inflammatory Markers in Autism Spectrum Disorders PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate some Inflammatory markers [IL-6, IL-8, TNF_alpha] in children with autism spectrum disorder |
GHADA MOHAMED ALI; | 2023-09-01 |
| 444 | Comparison of The Effectiveness of Exercise and Classical Massage in The Control of Edema in The Knee in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to compare the effectiveness of exercise and classical massage in the control of knee edema in patients with knee osteoarthritis. |
ÖĞR. ÜYESI ÖMER ŞEVGIN; | 2023-09-01 |
| 445 | 3D Joint Space Evaluation in Knee Osteoarthritis: The Importance of Weight-bearing and Flexion PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Osteoarthritis (OA) is mainly characterized by cartilage degeneration. In knee OA, measuring the distance between the tibia and femur, known as the joint space width (JSW), is an often-used method to quantify the progression of the disease or the effectiveness of treatments, because it is an indirect measure of cartilage degeneration. However, JSW is often measured while the patient is standing (weight-bearing) with slightly flexed knees, with a flexion angle of around 7-10 degrees, … |
MYLÈNE JANSEN; | 2023-09-01 |
| 446 | Immediate Analgesic Effects of Cheek Acupuncture for Acute Gouty Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the immediate analgesic effect and patients’ evaluation of the treatment of cheek acupuncture in patients with acute gouty arthritis. The main question it aims to answer are: Does cheek acupuncture has immediate pain relief effects on patients with acute gouty arthritis. Participants will received cheek acupuncture for 30 mins. If there is a comparison group: Researchers will compare etoricoxib group to see if cheek acupuncture is superior to etoricoxib for improvement of acute pain in subjects with acute gouty arthritis. |
YUPING LIN; | 2023-09-01 |
| 447 | Patient Satisfaction After Primary Total Hip Arthroplasty In Assiut University Hospitals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: measure the level of patient satisfaction after THA at the arthroplasty unit of Assiut University Hospital. |
AHMED HAMZA SAYED MOHAMED; | 2023-09-01 |
| 448 | Correlation of Fibrinogen to Albumin Ratio and C-reactive Protein to Albumin Ratio With Disease Activity in Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between FAR/CAR and Juvenile arthritis disease activity score (JASDAS27) in Juvenile idiopathic arthritis (JIA) |
MAHA SAYED IBRAHIM ABDELRAHMAN; | 2023-09-01 |
| 449 | The Effectiveness of Shoulder Terminal Sensory Articular Nerve Radiofrequency Ablation for Non-surgical Refractory Shoulder Pain Due to Rotator Cuff Pathology and Osteoarthritis; A Prospective Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Through this prospective, single-arm cohort pilot study, we plan to explore the safety and effectiveness of Shoulder Radiofrequency Ablation (SRFA) in patients with non-operative chronic shoulder pain due to shoulder osteoarthritis with or without rotator cuff tears. |
TAYLOR BURNHAM; | 2023-09-01 |
| 450 | The Effect of Progressive Relaxation Exercises on Postoperative Pain Intensity, Sleep Quality, and Recovery in Patients Undergoing Total Knee Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The indicators of patient recovery in the postoperative period include sleep, physical functionality, mental health, cognitive functionality, pain, and psychosocial functionality. This thesis aims to investigate the effects of progressive relaxation exercises on postoperative pain intensity, sleep quality, and recovery in patients undergoing total knee arthroplasty.This study, designed as a randomized controlled experimental study, will be conducted between September 1, 2023, and August 1, 2024, at ÇAYCUMA State Hospital in ZONGULDAK province, Turkey, among patients undergoing total knee arthroplasty. A total of 96 patients will be recruited based on the sample size calculated using G-power analysis. Through block randomization, … |
RUMEYSA BIRKANIM; | 2023-09-01 |
| 451 | Validity, Reliability, and Smallest Detectable Change of The Short Form 12-Item (SF-12) Health Survey in Individuals With Knee Osteoarthritis: A Cross-sectional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee Osteoarthritis (OA) is one of the most common joint diseases with chronic low-severity inflammation. 80% of individuals with knee OA have limited movements; It was found that 25% of them could not do their daily work. In addition, … |
MELTEM MERAN ÇAĞLAR; | 2023-09-01 |
| 452 | Functional Recovery After Total Knee Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about patients’ recoveries after receiving total knee arthroplasty (TKA). The main questions it aims to answer are: Does robotic-assisted TKA have improved perceived recovery when compared to conventional TKA? Does robotic-assisted TKA lead to improved functional recovery when compared to conventional TKA? Researchers will compare if robotic-assisted versus conventional procedures lead to different recovery speeds. Participants will answer questionnaires and undergo physical therapy testing before and at several timepoints after their procedure. |
KENNETH URISH; | 2023-09-01 |
| 453 | Randomized, Double-blind, Placebo-controlled, Multicenter Phase II Trial to Evaluate The Efficacy and Safety of TQH3821 Tablets in Patients With Treated Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and safety of TQH3821 in treated patients with moderate-to-severe active rheumatoid arthritis. |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2023-08-30 |
| 454 | Effects of Home Based Resistance Training As Compared to Supervised Resistance Training Exercise in The Management of Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis is a degenerative pathology that is characterized by structural changes in the joint, such as joint space narrowing, thickening of the joint capsule, and cartilage degeneration that encourages friction between the bone surfaces and causes pain, which is thought to be a major symptom of knee osteoarthritis. Knee osteoarthritis (OA) treatment focuses on reducing pain while also enhancing function and quality of life by resistant training and Home-based exercise, a time-effective and practical treatment option for people with chronic conditions. As the past literature states that home based trainings are cost and time effective, … |
FOUNDATION UNIVERSITY ISLAMABAD | 2023-08-30 |
| 455 | Randomized, Double-blinded, Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Genicular nerve neurolysis (GN) constitutes a relatively novel technique, whereby different chemical compounds (i.e. alcohol, phenol) are injected in close proximity to the genicular nerves of the knee joint, with the intention to exert a neurolytic effect by denaturing proteins resulting in Wallerian degeneration distal to the lesion. Based on the preliminary evidence and considering the potential benefits of the technique, we hypothesized that ultrasound-guided genicular chemical neurolysis with phenol is superior in terms of pain relief at 3 months, when compared to intra-articular steroid (IAS) injection. |
JAVIER WEBAR; | 2023-08-28 |
| 456 | Investigation of The Effects of Progressive Resistance Exercises on Pain, Functional Activity, Quality of Life and Serum Biomarkers in Individuals With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is known that the global socioeconomic burden of individuals with knee osteoarthritis (OA) is on a constantly rising curve. In addition, it is predicted that this burden will increase with the increase in the aging rate of countries. While the evidence level of exercise in the treatment of individuals with knee OA is at A level, a standard exercise program has still not been established for these individuals. One of the most important elements in establishing a standard exercise protocol can be realized by understanding how exercise provides positive effects in these individuals. Today, … |
MELTEM MERAN ÇAĞLAR; | 2023-08-28 |
| 457 | Effect of Whole Body Vibration Therapy on Pain, Muscle Strength, Balance and Quality of Life in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the effects of whole body vibration therapy on knee osteoarthritis. While the participants did static exercise in one group, whole body vibration therapy was applied during static exercise in another group. As a result of 15 sessions of treatment in both groups, the effects on pain, muscle strength, balance and quality of life were compared. |
BURAK ÇETINKAYA; | 2023-08-28 |
| 458 | Effect of Combination of Curcuminoid Standardized Turmeric Extract With Acupressure on Inflammatory Markers, Endorphins and Quality of Life in Elderly People With Osteoarthritis Genu PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to to investigate the efficacy of acupressure and standardized curcuminoids from turmeric extract to inflammatory markers, endorphin hormones in the blood and quality of life in elderly patient with Osteoarthritis Genu. The main questions it aims to answer are: 1. Is there any effect combination of acupressure and standardized curcuminoids from turmeric extract to inflammatory markers in elderly patients with Osteoarthritis Genu? 2. Is there any effect combination of acupressure and standardized curcuminoids from turmeric extract to endorphin hormones in the blood in elderly patients with Osteoarthritis Genu? 3. Is there an effect combination of acupressure and standardized curcuminoids from turmeric extract to quality of life in elderly patients with Osteoarthritis Genu? Participants in the intervention group received 2 treatments, namely acupressure at points that provide osteoarthritis-specific comfort and standardized curcuminoids from turmeric extract capsules. Participant in the control group alo would receive 2 treatments, an active placebo (starch capsules and sham acupressure). Researchers will compare interventional group and sham group to see efficacy the combination therapy |
SRINALESTI MAHANANI; | 2023-08-27 |
| 459 | Effectiveness of Probiotics and Standard Therapy Versus Standard Therapy Alone in Patients of Mild to Moderate Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the effectiveness of probiotics when given in combination with standard therapy in patients of mild to moderate rheumatoid arthritis |
FAWAD AHMAD RANDHAWA; | 2023-08-24 |
| 460 | A Pilot Study: Safety and Efficacy of Allogenic Mesenchymal Stem Cell Type AFCC for Treating in Elderly Knee Osteoarthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Amniotic fluid mesenchymal stem cells developed for chondrogenic treatment (AFCC) are used to treat elderly patients suffering from knee osteoarthritis (OA). The injection reduces inflammation and promotes the recovery of knee function, leading to an improved quality of life. |
TATSANEE PHERMTHAI; | 2023-08-17 |
| 461 | The Effect of Ultrasonographic Cartilage Thickness and Quadriceps/Hamstring Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The knee pain status of the patients who are followed in the rheumatology special branch of the Physical Medicine and Rehabilitation Outpatient Clinic and who meet the inclusion criteria will be questioned. In patients with or without knee pain, the cartilage thickness measurement of the knee joint will be measured from 3 points by ultrasound. At the same time, Quadriceps and Hamstring muscle thickness measurements of the patients will be made from the midpoints where the muscle thickness is the highest. The physician who performed the ultrasonographic measurements of the knee pain status of the patients does not know. |
AYLIN AYYILDIZ; | 2023-08-15 |
| 462 | The Frequency of Osteosarcopenia in Patients With Rheumatoid Arthritis and The Factors Affecting The Sarcopenia-osteoporosis Relationship PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study is a cross-sectional study, and its aim is to compare and analyze the prevalence of sarcopenia and osteoporosis in patients with rheumatoid arthritis (RA) with a control group and to reveal the impact of sarcopenia on osteoporosis, fall risk, and fracture risk. This prospective cross-sectional study will include 100 rheumatoid arthritis patients and 100 healthy controls, matched for age and sex. Patients will be consecutively and meticulously enrolled based on inclusion and exclusion criteria. A detailed medical history and examination will be performed on the patients, … |
ILHAN ÇAĞLAR KAYA; | 2023-08-15 |
| 463 | A Phase 2a Multicenter, Randomized, Double Blind, Parallel, Proof of Concept Study Evaluating The Efficacy and Safety of Nipocalimab and Certolizumab Combination Therapy in Participants With Active Rheumatoid Arthritis Despite Prior Treatment With Advanced Therapies (bDMARD or TsDMARD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of combination therapy with nipocalimab and certolizumab compared to certolizumab monotherapy. |
JANSSEN RESEARCH & DEVELOPMENT | 2023-08-15 |
| 464 | Comparison of The Efficacy of Dextrose Prolotherapy and Platelet Rich Plasma Injections in Patients With Knee Osteoarthritis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this prospective, randomized, controlled, single-blinded study, we aimed to evaluate the effects of Dextrose Prolotherapy and Platelet Rich Plasma injections in patients with chronic knee osteoarthritis. |
EKIN ILKE SEN; | 2023-08-15 |
| 465 | Outcome and Prognosis of Supported Self-management in Thumb Base Osteoarthritis: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background Thumb base osteoarthritis (OA) is common in adults 40 years and over. It affects a person’s ability to work, be independent and care for others. Sufferers complain of severe pain and difficulty in completing everyday tasks. The main treatment for the condition is advice on how a person can manage their condition (self-management), reduce their pain, strengthen their hands with exercises and practical tips on tackling painful tasks, … |
UNIVERSITY HOSPITALS OF DERBY AND BURTON NHS FOUNDATION TRUST | 2023-08-08 |
| 466 | Anatomic Versus Reverse Shoulder Arthroplasty for Primary Glenohumeral Osteoarthritis: A Randomized Prospective Study Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of the investigators prospective randomized study is to determine whether reverse total shoulder arthroplasty (RTSA) have at least as good results as anatomic TSA (non-inferiority), in patients with glenohumeral osteoarthritis, without rotator cuff tears nor significant glenoid retroversion. The secondary goals are 1) to evaluate whether RTSA eventually grants superior postoperative clinical and radiographic outcomes than anatomic TSA (superiority), … |
CHRISTOPHER JOYCE; | 2023-08-02 |
| 467 | A Randomised, Double Blind Placebo-controlled Trial Evaluating The Medical Food Synbiotic SBD121, Versus Placebo for The Clinical Dietary Management of Early Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomised, double-blind, placebo controlled clinical food trial is to determine if the medical food SBD121 Synbiotic (prebiotic and probiotic) will aid in the dietary management of symptoms of early rheumatoid arthritis (RA). |
SOLAREA BIO | 2023-08-01 |
| 468 | A Phase 3 Study to Investigate The Efficacy and Safety of LY3437943 Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of The Knee: A Randomized, Double-Blind, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the safety and efficacy of retatrutide once-weekly in participants who have obesity or are overweight and have osteoarthritis (OA) of the knee. The study will lasts about 77 weeks. |
ELI LILLY | 2023-08-01 |
| 469 | Cardiac and Pulmonary Assessment in Egyptian Patients With Rheumatoid Arthritis and Their Correlation With Disease Activity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine cardiac and pulmonary involvement in RA patients To assess the correlation between cardiopulmonary findings in RA patients with disease activity. To compare between diaphragmatic ultrasonography and PFT i.e. spirometry as a screening tool for restrictive pulmonary disorders. To assess correlation between anterior chest wall ultrasound and pulmonary function test in RA patients. |
YOSRA YOUSIF MAHMOUD NASSER; | 2023-08-01 |
| 470 | Efficacy of Pulsed High Intensity Laser Therapy in Treatment of Psoriatic Hand Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study was to evaluate the therapeutic efficacy of pulsed high intensity level laser therapy in improving symptoms of psoriatic hand arthritis. |
MAHMOUD SHAWKY HELMY ABDELHAMID; | 2023-08-01 |
| 471 | Effect Of Percussion Massage Gun On Hamstrings Flexibility In Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study would be to investigate: – The effect of using percussion massage gun on Hamstring flexibility in patients with knee osteoarthritis. – The effect of using percussion massage gun on pain in patients with knee osteoarthritis. – The effect of using percussion massage gun on ROM in patients with knee osteoarthritis. – The effect of using percussion massage gun on knee function in patients with knee osteoarthritis. |
HEBA MOHAMED MOAWED EL-BERKAWY; | 2023-08-01 |
| 472 | What Affects The Severity of Knee Osteoarthritis? Aging or Associated Metabolic Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis |
AMANY MOHAMED ABDELRAHMAN; | 2023-08-01 |
| 473 | Perioperative Pain Management for Total Shoulder Arthroplasty: A Pilot Non-Inferiority Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Total shoulder arthroplasty (TSA) is a common and effective treatment for end-stage shoulder pathologies. Over the past 25 years, implant designs have evolved and the indications for joint replacement have expanded significantly to include arthritis, rotator cuff arthropathy, complex shoulder trauma and trauma sequelae. This has resulted in a worldwide increase in rates of shoulder replacement surgery. The concomitant increased treatment burden for health care systems has prompted interest in strategies to improve the effectiveness and efficiency of patient care such as streamlining intraoperative procedures, mitigating complications, … |
LAWSON HEALTH RESEARCH INSTITUTE | 2023-08-01 |
| 474 | Clinical Study of 18F-labeled Probes Targeting Fibroblast Activating Protein and Integrin Avβ3 (FAPI-RGD) to Assess Disease Activity in Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about 18F-FAPI-RGD PET/CT imaging in assessing rheumatoid arthritis disease activity. Participants will undergo clinical evaluation and 18F-FAPI-RGD PET/CT examination. |
HAO WANG; | 2023-08-01 |
| 475 | A Comparative Study Between Transcutaneous Pulsed Radiofrequency Application Plus Genicular Nerve Block Versus Intra-Articular Hyaluronic Acid Injection for Management of Chronic Pain in Knee Osteo-arthritis: A Prospective Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present study is to compare the analgesic efficacy of combined transcutaneous pulsed radiofrequency plus genicular nerve block with bupivacaine plus corticosteroid versus intraarticular Hyaluronic acid injections, in terms of clinical and functional parameters, in patients with knee osteoarthritis. |
OMAR HASHEM MOHAMMED; | 2023-08-01 |
| 476 | Investigating The Most Effective Exercise Modality in Knee Osteoarthritis; A RCT PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess and compare the effectiveness of three different exercise modalities-whole-body vibration exercise, progressive resistance exercise, and home-based exercise -in improving quadriceps isometric muscle strength, physical function, balance, knee pain, osteoarthritis symptoms, and overall quality of life in individuals with knee osteoarthritis. The main questions it aims to answer are: – How do WBV, PRE, and home-based exercise compare in improving quadriceps strength in people with knee osteoarthritis? – Which exercise modality leads to the greatest improvements in physical function, balance, knee pain, … |
MUSTAFA ALABDALLAH ALALEWY; | 2023-08-01 |
| 477 | NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis: A Randomized, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Researchers are trying to compare two different types of intraarticular injections (injection in the joint) for treating the symptoms of moderate to advanced basilar thumb arthritis. One injection is ketorolac (an NSAID) and the other is triamcinolone (a corticosteroid). |
MARCO RIZZO; | 2023-07-28 |
| 478 | Evaluation of The Efficacy of Genicular Nerve Alcohol Neurolysis in The Management of Knee Osteoarthritis Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to evaluate the efficacy of genicular nerve alcohol neurolysis in the treatment of pain caused by chronic knee osteoarthritis. The investigators will evaluate the efficacy of genicular nerve alcohol neurolysis using the numeric rating scale (NRS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) through patients’ medical records. NRS and WOMAC scores will be evaluated before, 1, and 3 months after the procedure. |
DAMLA YÜRÜK; | 2023-07-28 |
| 479 | Comparison of Neuropathic Pain Symptoms in Hand Osteoarthritis and Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It was aimed to compare neuropathic pain symptoms in hand osteoarthritis and rheumatoid arthritis. |
SELDA ÇIFTCI; | 2023-07-27 |
| 480 | The Distribution of Immunoglobulin Isotype in Polyclonal Hypergammaglobulinemia in Systemic and Autoimmune Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Polyclonal hypergammaglobulinaemia is characterized by increased levels of immunoglobulins and is a common feature observed in various diseases such as autoimmune diseases, chronic infectious diseases or lymphoid hemopathy. Some autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis or Sjögren’s syndrome are frequently associated with polyclonal hypergammaglobulinaemia. Recent data have suggested that the distribution of immunoglobulin isotypes in polyclonal hypergammaglobulinaemia may be disease-specific. However, isotype repartition in polyclonal hypergammaglobulinaemia remains poorly understood. The investigators will investigate the distribution of immunoglobulin isotype in patients with autoimmune disease and polyclonal hypergammaglobulinaemia. Moreover, … |
CENTRE HOSPITALIER UNIVERSITAIRE AMIENS | 2023-07-27 |
| 481 | Combining A CD40L-Binding Protein (VIB4920) With A TNF-alpha Inhibitor for The Treatment of Inadequately Controlled Rheumatoid Arthritis (ITN092AI) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective is to determine if the addition of a 12-week course of treatment with VIB4920 to TNFi treatment will result in improved clinical disease control in patients with RA who have had an inadequate response to a TNFi. |
JONATHAN GRAF; | 2023-07-25 |
| 482 | Assessment of Maximal Rate of Force Development of Ankle Muscles and Its Association Functional Ability in Patients With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a detailed assessment of the maximal rate of force development of ankle muscles and its association with functional ability in patients with knee osteoarthritis (OA). |
MOHAMED MAGDY ELMELIGIE; | 2023-07-20 |
| 483 | Assessment of Physician Consideration of Electronic Patient Reported Outcomes, from Patients with Gout, Rheumatoid Arthritis, Sjogren’s Syndrome or Systemic Lupus Erythematosus, on The Frequency of Therapeutic Adjustments PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Inflammatory rheumatic diseases affect 1% of the population. Treatment of such diseases should be based on disease activity, safety issues and other patient characteristics such as comorbidities (EULAR, 2022), leading to a higher risk of cardiovascular diseases. To this end, the general treat-to-target approach, as recommended in the EULAR guidance, … |
UNIVERSITY HOSPITAL STRASBOURG FRANCE | 2023-07-18 |
| 484 | Clinical Study Evaluating The Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluating the effect of the flavonoids combination (diosmin and hesperidin) as adjuvant therapy on patients with rheumatoid arthritis |
AHMED ABDELBAR; | 2023-07-18 |
| 485 | A Multicenter, Randomized, Open-label Phase IIb Clinical Study to Evaluate The Efficacy and Safety of GenaKumab in The Treatment of Active Systemic Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A multicenter, randomized, open-label Phase IIb clinical study to evaluate the efficacy and safety of GenaKumab in the treatment of active systemic juvenile idiopathic arthritis. |
GENESCIENCE PHARMACEUTICALS | 2023-07-16 |
| 486 | Associations Between Psychological Factors, Pain Sensitivity, and Physical Function in Knee Osteoarthritis: A One-year Follow Up Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine if baseline measures of psychology and pain sensitivity can predict changes in physical function at 1 year in patients with knee osteoarthritis. |
MOHAMED MAGDY ELMELIGIE; | 2023-07-15 |
| 487 | The Mediating Effect of Nociplastic Pain on The Relationship Between Rheumatoid Arthritis Severity and Cognition in Geriatric Patients: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: this study aims to determine if nociplastic pain mediates the relationship between rheumatoid arthritis (RA) severity and cognitive impairment in geriatric patients 100 patients aged 65-90 years with long-standing RA and assess their disease severity, cognition, and pain sensitization will be recruited. Expectations that patients with more severe RA will have worse cognitive function, and that this relationship will be mediated by higher levels of nociplastic pain. |
MOHAMED MAGDY ELMELIGIE; | 2023-07-15 |
| 488 | Prospective Non-Interventional Study on Structum® in Adult Patients with Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chondroitin sulfate (CS) is a SYSADOA and a natural biomacromolecule belonging to the class of glycosaminoglycans. CS is a major component of the extracellular matrix (ECM), where it constitutes an essential component of proteoglycans. To this date, no real-world studies have been conducted to precisely describe the burden associated with OA among patients treated with CS.Therefore, an observational, descriptive, prospective, national study will be conducted to describe the burden associated with OA and the quality of life of patients treated with Structum® in Poland. |
PIOTR WILAND; | 2023-07-12 |
| 489 | Use of Allocetra-OTS in End Stage Knee Osteoarthritis – Assessment of Safety PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study to assess safety and possible efficacy of Allocetra-OTS in end-stage knee osteoarthritis. |
AMIR ORON; | 2023-07-12 |
| 490 | Positioning of Continuous Adductor Canal Catheters After Total Knee Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to determine the incidence of dislodgement for adductor canal catheters after total knee arthroplasty on post-operative day 1. We will also attempt to identify factors associated with secondary catheter failure. |
SUNNYBROOK HEALTH SCIENCES CENTRE | 2023-07-10 |
| 491 | The Effect of Graded Motor Imagery on Pain and Function in Individuals With Knee Osteoarthritis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate whether Graded Motor Imagery (GMI) application is as effective as Transcutaneous Electrical Nerve Stimulation (TENS) in individuals with knee osteoarthritis (OA). The objectives are to improve range of motion (ROM) and muscle strength, reduce pain and stiffness, increase pain pressure threshold, and enhance function and physical performance through GMI application. |
ZEYNEP YILDIZ KIZKIN; | 2023-07-10 |
| 492 | Effect of Eye Movement Desensitization and Reprocessing (EMDR) on Pain in Patients With in Patients Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: They explained the improvement of pain in patients with EMDR treatment in chronic pain with Shapiro’s adaptive information processing model. According to this model; The nociceptive sense is related to the emotional response. During the traumatic event, the painful stimulus is stored both physically and as an image, thought, and affect. Therefore, traumatic memories contain affective elements as well as conscious awareness and contribute significantly to stress along with chronic pain. Reprocessing these dysfunctionally stored memories will allow the problematic memories to integrate, … |
MÜJDE MORAN; | 2023-07-10 |
| 493 | Efficacy of Percutaneous Electrical Stimulation Compared to Transcutaneous Electrical Stimulation in Combination With An Education and Exercise Program in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare the effectiveness of percutaneous electrotherapy treatment with transcutaneous and placebo. |
JOSUE FERNANDEZ CARNERO; | 2023-07-06 |
| 494 | A 24-Week Multicenter, Open-label, Single-arm, Phase 4 Study to Evaluate The Safety of Ixekizumab in Patients With Moderate-to-Severe Plaque Psoriasis or Active Psoriatic Arthritis in India PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to investigate the safety and tolerability of ixekizumab in participants in India with moderate-to-severe plaque psoriasis (PsO) or active psoriatic arthritis (PsA) |
SATYAKI GANGULY; | 2023-07-05 |
| 495 | Incidence of Tenderness Opposite to Adductor Canal in Patients Suffering From Osteoarthritis Knee Pain. A Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Knee osteoarthritis (KOA) is a common knee disorder. The pathological changes affecting the knee are typically examined by using X-ray imaging to assess the narrowing of the joint space and the presence of osteophytes. However, some previous clinical trials have revealed a discrepancy between the severity of joint pain and the image finding even with the use of knee MRI. Some studies have revealed that there are age-related changes in the type of fibers with the formation of a network of transverse fiber bands, … |
ABEER AHMED; | 2023-07-01 |
| 496 | A Phase II, Blinded, Randomised, Placebo Controlled Clinical Trial to Determine The Safety and Effect on Pain and Function According to RAPID-3 of IHL-675A in Patients With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomised, double-blind, placebo-controlled Phase II clinical trial is to assess the safety and effect of of IHL-675A in rheumatoid arthritis patients on pain, and function according to RAPID-3. 128 volunteers will be enrolled and randomised to one of four treatments (32 subjects per treatment). Each treatment will be self-administered twice daily for 24 weeks. The four treatments are: – Treatment 1 – IHL-675A – Treatment 2 – CBD – Treatment 3 – HCQ – Treatment 4 – Placebo |
STEPHEN HALL; | 2023-07-01 |
| 497 | Frequency Assessment of Leukocyte Immunoglobulin-like Receptors A3 In Ankylosing Spondylitis And Axial Psoriatic Arthritis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To evaluate the frequency of LILRA3 in Ankylosing spondylitis and Axial psoriatic arthritis patients. 2. To investigate the association of LILRA3 with Ankylosing spondylitis and Axial psoriatic arthritis disease activity and severity. |
ALAA ADEL ABDELMOEZ; | 2023-07-01 |
| 498 | Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to BDMARD or TsDMARD +/- CsDMARD Changing Treatment to A BDMARD or TsDMARD Treatment +/- CsDMARD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of this study is to assess a cfDNA-based blood test using genetic, transcriptomic and/or epigenetic information to help doctors predict the best treatment options for rheumatoid arthritis (RA) patients with inadequate response or intolerance to previous therapies. |
AQTUAL | 2023-07-01 |
| 499 | Investigator Initiated Trial to Evaluate Cartilage Regeneration By Arthroscopy in Patients With K-L Grade III Knee Osteoarthritis After JOINTSTEM Administration PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to confirm cartilage regeneration through arthroscopy after a single administration of autologous Adipose Tissue derived Mesenchymal stem cells(JOINTSTEM) in patients with degenerative arthritis of K-L grade 3 |
CHANGMIN LEE; | 2023-07-01 |
| 500 | Knee Osteoarthritis and Lazer Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that causes hypertrophic changes in bone. OA is a non-inflammatory progressive musculoskeletal disease and is one of the most common degenerative diseases in the general population. OA is characterized by progressive cartilage destruction in load-bearing joints, subchondral sclerosis, osteophyte formation, and some biochemical and morphological changes in the synovial membrane and joint capsule. Common symptoms of knee osteoarthritis are; Knee pain that increases with activity, limitation of normal joint movement of the knee, edema, … |
METEHAN YANA; | 2023-07-01 |