Clinical Digest: Recent Clinical Trials on Autism
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Autism. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Autism
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Scalp Acupuncture Treatment for Chronic Tic Disorders in Children: A Multicenter Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if scalp acupuncture works to treat chronic tic disorders (CTD) in children. It will also learn about the safety of scalp acupuncture. The main questions it aims to answer are: * Does scalp acupuncture improve clinical symptoms and social functioning, … |
HAO ZHOU; | 2025-05-01 |
| 2 | A ‘Proof of Concept’ Study to Identify Neural Target Engagement of Escitalopram in Adolescents With Autism Spectrum Disorder Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the acute effects of escitalopram (Lexapro®) on select brain networks during task-based functional magnetic resonance imaging (fMRI) in adolescent individuals with autism spectrum disorder (ASD). We hope to learn more about the acute effects of escitalopram and how it might be used to treat inflexible thinking or rigid-compulsive behavior that can be associated with restricted and repetitive behaviors in adolescents with ASD. Participants will: * Attend 3 visits to complete tests of thinking abilities and fill out surveys about their health and behavior * Be randomly assigned to receive escitalopram at one of the first two visits after screening and a placebo at the other visit. * Complete 2 MRI scans while doing a reward-based task that tracks eye movement |
KATHRYN UNRUH; | 2025-05-01 |
| 3 | Transcranial Magnetic Stimulation Guided By Personalized Brain Functional Sectors (pBFS) for Language Deficit Comorbid in Autism Spectrum Disorder Child: A Multi-center, Randomized, Sham-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this trial is to evaluate the efficacy and safety of precision neuromodulation in improving language ability in children with autism spectrum disorder (ASD) who also have language development delay. The neuromodulation will be delivered using the accelerated intermittent theta burst stimulation (aiTBS) protocol, targeting the language network in the left superior frontal gyrus (SFG), guided by personalized Brain Functional Sector (pBFS) technology. |
BEIJING CHANGPING TIANHE RESEARCH INSTITUTE OF BRAIN SCIENCE | 2025-04-25 |
| 4 | An Evaluation of Care (Education) and Treatment Reviews for People With Learning Disabilities and Autistic People (CECILIA) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Aims In this research project, we will determine whether Care (Education) and Treatment Reviews are helpful for people with learning disabilities and autistic people and their families. Background Care (Education) and Treatment Reviews were started in 2014 to help get autistic people and people with learning disabilities out of psychiatric hospitals and to prevent their admission to psychiatric hospitals. Care (Education) and Treatment Reviews involve an independent panel including an Expert by Experience, a clinician, … |
COVENTRY AND WARWICKSHIRE PARTNERSHIP NHS TRUST | 2025-04-15 |
| 5 | Differences in Prosocial Behaviors and Related Brain Networks in Children With Autism and Typical Development PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare the brain functional network between children with autism and typical development, using magnetic resonance imaging (MRI), electroencephalogram/event-related potentials(EEG/ERPs) and functional Near Infrared Spectrum(fNIRs). The main questions it aims to answer are as follows: 1. What are the differences of the functional brain network between autism and TD children? 2. What are the differences of the brain activity in response to special social stimulus between autism and TD children? Participants will receive developmental/intelligence assessments (Griffiths Mental Developmental Scales/Wechsler Preschool and Primary Scale of Intelligence-IV/Wechsler Intelligence Scale for Children-IV for children of different ages), social assessments(Autism Diagnostic Observation Schedule-2nd Edition/Social Communication Questionnaire), EEG/ERPs and fNIRs in resting and task states, and head MRI in natural sleeping state(without sedative). |
XIU XU; | 2025-04-15 |
| 6 | Effects of Standardized Walking Obstacle Course (SWOC) Activities on Balance, Gait and Endurance in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is a developmental disorder characterized by challenges in social communication, social interaction, repetitive behaviors, and restrictive interests. Affecting 0.2-2% of children, ASD often includes motor growth retardation, which worsens over time. The disorder is more commonly diagnosed in boys, and its cause is believed to be genetic, with environmental stimuli potentially activating certain genes. This study aims to explore the effects of Standardized Walking Obstacle Course (SWOC) activities on balance, gait, and endurance in children with ASD, … |
KAINAT SUBTAIN; | 2025-04-15 |
| 7 | A Target Engagement Study of Pimavanserin for Behavioral Inflexibility With Open Label Trial for Rigid Rigid-compulsive Behavior in Adolescents and Adults With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase 2 study examines the safety, tolerability, and preliminary efficacy of pimavanserin in individuals with Autism Spectrum Disorder. Male or female participants aged 16 to 40 years of age will be randomized to receive single doses of either placebo or pimavanserin in this randomized, placebo-controlled, cross-over designed study, followed by open label extension. |
JEREMY VEENSTRA-VANDERWEELE; | 2025-04-15 |
| 8 | Effects of Image-Sand Play Therapy Versus Table Top Training Program With Weighted Cuffs on Visual Motor Integration in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares Image-Sand Play Therapy and Tabletop Training with Weighted Cuffs for improving Visual-Motor Integration (VMI) in children with autism. A 12-week randomized controlled trial will be conducted at Tanzeem-ul-Nisan, Faisalabad. Beery VMI will assess outcomes. Data will be analyzed using SPSS-23. Non-probability conventional sampling will be used. Sessions occur twice weekly. |
HAMNA FAISAL; | 2025-04-15 |
| 9 | Trial Readiness and Endpoint Assessment in Pediatric Myotonic Dystrophy Extension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a natural history study to improve the types of assessments and biological samples that will be used in clinical drug trials in both congenital myotonic dystrophy and childhood myotonic dystrophy. |
NICHOLAS JOHNSON; | 2025-04-14 |
| 10 | The Effect of Dual-tasking Program on Cognitive and Physical Functions and Independence in Activities of Daily Living in Children with Duchenne Muscular Dystrophy: A Single-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and frequent developmental, cognitive and behavioral impairments, occurring in one in 5000 live births of boys. DMD is caused by a deficiency of the protein dystrophin, which maintains the structure and functionality of muscle cells. The absence of dystrophin leads to the weakening and eventual death of muscle cells, resulting in reduced muscle strength and impaired motor function. In early childhood, children with DMD may experience delays in basic motor skills such as walking and standing. Later in life, … |
BAŞAK ÇAĞLA ARSLAN; | 2025-04-14 |
| 11 | Stereotypi in Motor-, Vocal- and Feeding Behaviors: Novel Extensions to Adults Related Papers Related Patents Related Grants Related Experts View Highlight: Adults with developmental disabilities (DD) and autism represent a vulnerable demographic that transitions into adulthood with diverse etiologies, exhibiting a significantly higher prevalence of various challenging behaviors. These problematic behaviors can lead to adverse health outcomes and a diminished quality of life. Addressing these issues often necessitates an interdisciplinary approach to continuity of care, focusing on enhancing functional skills, empowerment, and independence, as well as preventing and mitigating challenging behaviors. The current research proposal comprises of three studies designed to evaluate the efficacy of behavioral interventions for problematic behaviors in adults with DD and autism. If left unaddressed, … |
PETUR INGI PETURSSON; | 2025-04-08 |
| 12 | Effect of Cognitive-Behavioral Strategies on Self-Efficacy, Sense of Coherence, and Psychological Ownership Among Nurses Caring for Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if a structured training program in cognitive-behavioral strategies can improve: Self-efficacy: The belief in one’s ability to succeed in specific tasks or situations. Sense of coherence: A perception of life as comprehensible, manageable, and meaningful. Psychological ownership: A sense of possession or attachment to one’s job or role. These outcomes are critical for nurses working with children with ASD, as their role involves unique emotional and professional challenges. The study will use a rigorous scientific approach to assess the effectiveness of the intervention. |
PORT SAID UNIVERSITY | 2025-04-05 |
| 13 | Prevalence of Neurodevelopmental Disorders in A Homeless Population – Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction \& Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder). Methods / approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, … |
CAROLINE DEMILY; | 2025-04-01 |
| 14 | A Multi-center, Randomized, Double-blind, Placebo-controlled, Therapeutic Exploratory Phase II Clinical Trial to Evaluate The Efficacy and Safety of NV01-A02 in Children With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled, therapeutic exploratory Phase 2 clinical trial designed to evaluate the efficacy and safety of NV01-A02 in pediatric participants diagnosed with Autism Spectrum Disorder (ASD). |
NEUROVENTI | 2025-04-01 |
| 15 | Evaluating An Integrated Habituation Programme for Enhancing Dental Examination Acceptance in Children With Autism Spectrum Disorder: An Effectiveness Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this effectiveness trial is to investigate if an integrated dental habituation programme can enhance acceptance of a clinical dental examination in children (aged 5-8 years) with autism spectrum disorder (ASD). The main questions it aims to answer are: * Can a dental habituation programme performed by trained dental hygienists increase the acceptance of a clinical dental examination in children with ASD? * Is a dental habituation programme for children with ASD more effective compared to home preparation using visual aids performed by parents/guardians in increasing the acceptance of a clinical dental examination in children with ASD? The study participants will be randomly assigned to either the habituation group (intervention) or the home preparation group (augmented control) to investigate the effectiveness in increasing acceptance and cooperation of a clinical dental examination. |
LENE ELISABETH MYHREN; | 2025-04-01 |
| 16 | The More Than Words® Program for Parents of Young Children With Social Communication Challenges: A Pilot Pragmatic Randomized Waitlist-Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: More Than Words® – The Hanen Program® for Parents of Autistic Children or Children Who May Benefit from Social Communication Support is a family-focused intervention program delivered by a speech-language pathologist (SLP). The goal of More Than Words is to empower parents to be the main facilitator of their child’s social communication development, which increases the child’s opportunities to develop social communication skills in everyday situations. It is one of the programs offered to families who receive services from Ontario’s Preschool Speech and Language program, … |
JANIS ORAM; | 2025-04-01 |
| 17 | Efficacy of Nutritional Supplements on Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if nutritional supplements could alleviate the clinical symptoms in children with autism spectrum disorder. It will also learn about the safety of these nutritional supplements. Researchers will compare the combination of nutritional supplements and behavioral intervention, to behavioral intervention alone, to see if nutritional supplements work to treat autism. Participants will receive the combination of nutritional supplements and behavioral interventions or solely behavioral interventions for 3 months. And they will visit the clinic at the beginning of the trial (baseline) and after the 3-month intervention period for examinations. |
FEI LI; | 2025-04-01 |
| 18 | NDBI Training and Coaching PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Naturalistic developmental behavioral interventions (NDBIs) are a newer class of evidence-based interventions for young autistic children to promote their positive developmental or behavioral outcomes. These are often delivered by family members or other natural change agents given the emphasis on naturalistic transactions between an adult and a child. Despite the emerging evidence, there are practical difficulties that hinder wider dissemination and implementation of NDBIs, including low level of access to some of these branded, packaged NDBIs. To mitigate these difficulties related to access, … |
JAMES D LEE; | 2025-04-01 |
| 19 | CONEXUS: Prospective Study of The Feasibility of Brain Connectivity Imaging By Functional Ultrasound Imaging (fUS) in Newborn Infant PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Neurodevelopmental disorders (NDD) affect how the brain develops and can lead to lifelong difficulties with movement, learning, behavior, and thinking. Every year, around one million newborns in Europe are affected by these conditions. Some babies are at higher risk of NDD due to factors such as being born extremely premature, having poor growth in the womb, experiencing a lack of oxygen at birth, or having a family history of severe NDD. However, … |
VALERIE BIRAN; | 2025-04-01 |
| 20 | Suramin for The Treatment of Autism Trial (STAT): A Randomized, Double Blind, Crossover Trial of KZ101 in A Male Pediatric Population With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Suramin has been found to correct the symptoms, metabolism, and brain synaptic abnormalities in two classical genetic and environmental mouse models of autism. A preliminary clinical trial (SAT-1) examined the safety and activity of a single low-dose of suramin in children with ASD and concluded suramin showed promise as a novel approach to treatment of ASD. The current study, STAT-2A, will be a randomized, double-blind, crossover, 30-week study to evaluate the preliminary proof of concept, safety, … |
ARAM KIM; | 2025-04-01 |
| 21 | ASPE Subproject – Training to Understand and Navigate Emotions and Interactions (TUNE In) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test a novel, cognitive behavioral treatment strategy to improve social functioning in adults with autism spectrum disorder. The treatment, named TUNE In (Training to Understand and Navigate Emotions and Interactions), includes components to address the many behavioral domains involved in social functioning, including social motivation, social anxiety, social cognition, social skills, and generalization of the skills to community settings. The Investigators will test the efficacy of TUNE In to improve social functioning in adults with autism spectrum disorder (ASD), using a randomized controlled trial using the SRS-2 as the primary outcome measure. |
EDWARD BRODKIN; | 2025-03-24 |
| 22 | Effects of Receptive Language Intervention Vs Individual Therapy for Preschool Children With PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and social interaction and the presence of restricted, repetitive behaviors. Atypical behaviors, conditioning, … |
SYEDA MARIAM ZAHRA; | 2025-03-20 |
| 23 | Effect of Sensory Integration in Speech Therapy for Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is considered one of the commonest developmental disabilities, characterized mainly by impairments in social performance and communicative skills, repetitive stereotypical behaviors, and restriction in interests and activities, with a combination of sensory, cognitive, behavioral, and communication features which persist throughout life. Caminha \& Lampreia specified that there is a significantly high prevalence of sensory processing dysfunctions in ASD. Sensory processing means how the central and peripheral nervous systems deal with the incoming sensory input from different sensory organs; visual, auditory, smell, taste, tactile, proprioception, … |
HINA OMER; | 2025-03-17 |
| 24 | Effects of Qigong Sensory Training on Sensory Modulation and Behavior in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social interaction, communication, and a range of repetitive behaviors. Among these challenges, sensory processing abnormalities are highly prevalent, manifesting as hyper- or hypo-sensitivity to sensory stimuli, and can significantly impact daily functioning and quality of life. In sensory modulation there are difficulties in regulating and responding appropriately to sensory input from the environment. Sensory modulation can have a significant impact on the daily lives of individuals with autism, affecting their ability to engage in various activities and navigate social interactions. Autistic children also have repetitive behaviors, … |
MUHAMMAD YOUSAF; | 2025-03-17 |
| 25 | Effects of Treadmill Training With and Without Compression Stockings on Toe Walking and Balance in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) affects around 1.7% of US children, with co-occurring conditions like ADHD, anxiety, and epilepsy complicating daily functioning. Early intervention strategies, such as sensory-based therapies and physical exercises like treadmill training, are used to improve motor skills and overall functioning in children with ASD. A randomized controlled trial is being conducted to evaluate the impact of treadmill interventions on children with toe-walking behaviors. Participants will be assigned to either Group A or Group B, … |
QUTBIA ABAQ JAVED CHEEMA; | 2025-03-15 |
| 26 | In-Home Parent-Child Training System: Validation Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Koronis Biomedical Technologies Corporation (KBT) is developing a cognitive intervention to promote healthy development of Executive Function (EF) skills in young children by leveraging a smartphone-based training regime designed for parents. |
STEPHANIE M. CARLSON; | 2025-03-10 |
| 27 | The Effect of Mindfulness-Based Stress Reduction Programme on Stress, Anxiety, Self-Compassion and Prenatal Attachment in Pregnant Women with Perinatal Loss; A Randomised Controlled StudyMBSR PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research will be conducted to examine the effects of a mindfulness-based stress reduction (MBSR) programme on stress, anxiety, self-compassion and prenatal attachment in pregnant women with perinatal loss. This randomised controlled trial was conducted with 80 pregnant women with perinatal loss (40 participants in the experimental group and 40 participants in the control group). The experimental group will receive a total of eight sessions of MBSR in two sessions per week for four weeks. The data of the study will be collected by Personal Information Form, Tilburg Distress in Pregnancy Scale, Self-Compassion Scale Short Form, … |
HATICE GUL OZTAS; | 2025-03-10 |
| 28 | Effects of Multiple-Session Transcranial Direct Current Stimulation (tDCS) on Behavioral, Physiological, and Electrophysiological Measures With Adults With Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to investigate the effects of multiple sessions of transcranial direct current stimulation (tDCS) delivered while participants complete tasks that target social learning with high functioning adults with ASD and/or high traits of ASD. The main question it aims to answer is: What are the effects of multiple sessions of active compared to sham tDCS, with tDCS simultaneously paired with social learning tasks, from employing a within-subject, cross-over randomized controlled trial design? Participants will: * Complete a randomly assigned block of 5 sessions of active and a block of 5 sessions of sham tDCS, … |
UNIVERSITY OF NEW MEXICO | 2025-03-04 |
| 29 | Behavioural Activation for Depression in Adults with Severe Learning Disabilities. A Feasibility Randomised Controlled Study of Behavioural Activation with Treatment As Usual (TAU) Vs TAU Alone PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Research shows that people with severe learning disabilities get depressed at least as often as the wider population. Psychological therapies are recommended to treat depression, and some of these have been adapted for those people with learning disabilities who can talk about their problems. No research has properly tested a psychological therapy for people with severe learning disabilities and any mental health problem. The investigators recently completed a study that tested a psychological therapy (behavioural activation) for people with mild learning disabilities and depression. Behavioural activation improves people’s mood by helping them to re-engage in activity that has meaning and purpose for them, rather than relying on talking or thinking skills. Because of this behavioural activation might be promising for people with severe learning disabilities and depression. Along with PAMIS, an organisation for families of people with more profound disabilities, the investigators have adapted the therapy for this group. The investigators now want to find out if it would be possible to carry out a research project about whether behavioural activation works for depressed adults with severe learning disabilities. This is called a feasibility study. The investigators would see if it is possible to recruit 50 adults with severe learning disabilities, and if they are willing to be randomly placed in a group who get behavioural activation or a group who get usual help from services. Other information about running a study would be collected, including about keeping in contact with participants and what measures are needed to find out if change is happening. |
NHS GREATER GLASGOW AND CLYDE | 2025-03-04 |
| 30 | Randomized Pragmatic, Cluster, Stepped-wedge Trial of Early Detection and Referral for Autism and Neurodevelopmental Disorders at The Maternal and Child Protection Services for Care Before 1 Year of Follow-up PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare two screening strategies for identifying infants with a potential risk of Autism Spectrum and Neurodevelopmental Disorders to provide early access to care and increase the likelihood of a favorable outcome |
CENTRE HOSPITALIER INTERCOMMUNAL CRETEIL | 2025-03-01 |
| 31 | How The Simultaneous or Delayed Presentation of Visual and Auditory Stimuli Affects Response Accuracy and Reaction Times in Participants with Autism Spectrum Condition (ASC) During An Association Task PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to examine how the mode of presentation of visual and auditory stimuli-separate or simultaneous-affects accuracy and reaction time in visual-auditory association in participants with Autism Spectrum Condition (ASC) compared to neurotypical individuals. The study aims to evaluate whether sensory overlap (simultaneous stimuli) increases cognitive load and decreases performance, while stimulus separation (separate presentation of visual and auditory stimuli) may facilitate processing and improve performance, … |
FLAVIA MARINO; | 2025-03-01 |
| 32 | A Pharmaco-Imaging Trial of Mixed Amphetamine Salts for The Treatment of ADHD in Intellectually-intact Youth with Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We are conducting a 10-week brain imaging and medication study. We are doing the research to study the response of ADHD in youth with ASD on extended-release formulation of mixed amphetamine salts (MAS) (also know as Adderall XR). We also want to find out if taking MAS has any effect on the brains of children and adolescents with ADHD and ASD. This study will help researchers better understand how the use of MAS to treat ADHD effects children and adolescents with ASD. We will compare MAS to a placebo. The placebo will look exactly like the MAS capsules but will contain no MAS. During this study, participants may get a placebo instead of MAS. Placebos are used in research studies to see if the study results are due to the study drug or due to other reasons. Participants with ASD and ADHD will complete 4-weeks of treatment with the study medication or placebo. They will complete bi-weekly study visits virtually via a telemedicine platform with the study doctor and complete questionnaires. On alternating weeks, they will meet with a MGH study team member to discuss medication adherence and potential side effects. Participants will have the option to attend all study visits in-person if you prefer. They will also complete baseline and endpoint MR scan visits at MIT. During the MR Scan visits, they will complete a series of tasks to measure inattention, impulsivity, reward sensitivity, decision-making, and working memory. Participants without ADHD or ASD will complete eligibility screening with MGH. If eligible, they will be invited to baseline and endpoint MRI scan visits at MIT. During the MRI Scan visits, they will complete a series of tasks to measure inattention, impulsivity, reward sensitivity, decision-making, and working memory. |
GAGAN JOSHI; | 2025-03-01 |
| 33 | The Effects of Community-based Sailing Program on Resilience of School-aged Children with Autism: A Pilot Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot RCT is to evaluate the feasibility and acceptability of the community-based sailing program and to assess the preliminary effects before the main RCT, given the literature on sailing for children with ASD has not yet been established. Does community-based sailing improve the resilience of participants? Does community-based sailing improve the quality of life, self-esteem, depressive symptoms and social functioning outcomes of participants? Researchers will compare the effect of community-based sailing to the attention control group at baseline following randomisation and post-intervention Participants will: Participate in a community-based sailing program over four days, … |
MYRIAN SZE NGA FAN; | 2025-03-01 |
| 34 | The Effect of Virtual Reality Homework Exercises As An Add-On to Behavioral Therapy for Children with Selective Mutism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Selective mustism (SM) is an anxiety disorder that manifests in childhood. Children with Children with SM do not speak in certain social situations where this is expected of them. For example, a child may talk at home, … |
LUUK STAPERSMA; | 2025-03-01 |
| 35 | Electrophysiological Correlates of Anxiety-related Improvements Following Cognitive Behavioral Therapy for Autistic Youth in High-Need Communities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate neural constructs related to anxiety symptoms in response to Facing Your Fears (FYF) treatment in autistic participants with co-occurring anxiety. Researchers will compare participants receiving immediate FYF intervention to those in the waitlist control group (receiving treatment as usual) to see if there are differences in neural constructs and anxiety symptom changes over the study period. Participants will: * Complete the Facing Your Fears (FYF) intervention if assigned to the immediate treatment group * Continue their usual treatment during a waitlist period if assigned to the control group, … |
ERIN KANG; | 2025-03-01 |
| 36 | Optical Imaging As A Diagnostic Tool for Monitoring Brain Function in X-linked Rare Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fragile X syndrome (FXS, OMIM #300624) and Creatine Transporter Deficiency (CTD, #300352) are the two most common causes of X-linked intellectual disability. FXS and CTD affect hemizygous males and with highly variable severity heterozygous females. Both these neurodevelopmental disorders (NDDs) have a dramatic impact on the family quality of life and the health-care system. These disorders share common clinical traits, including intellectual disability, autistic-like features, behavioural and mood alterations and seizures. Brain anatomy appears largely normal, suggesting that functional deficits result from subtle changes in synaptic connectivity. Moreover, … |
HOSPICES CIVILS DE LYON | 2025-03-01 |
| 37 | A Multicenter Pilot Clinical Trial to Prevent Infantile Spasms Relapse PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After initially successful treatment, many children with infantile spasms unfortunately have a relapse, and relapse is linked to poor long-term outcomes such as autism and other forms of epilepsy. The aim of this study is to determine if treatment with low-dose prednisolone is safe, well tolerated, and effective in reducing the risk of relapse. |
SHAUN HUSSAIN; | 2025-03-01 |
| 38 | The Effect Of Exercise On Performance And Quality Of Life In Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if regular exercise intervention may improve the health status of the participants diagnosed with autism spectrum disorder, ages between 5-13 years old. The main question it aims to answer is: * if combined regular exercise program improves motor skills, repetitive movements, aerobic capacity and quality of life of participants? * Researchers will compare the exercising and non-exercising participants to see if regular exercise improves the health related parameters. Participants will do exercise for 12 weeks regularly. |
ŞENSU DINÇER; | 2025-02-27 |
| 39 | Use of Eye Tracking to Study Social Perception Abnormalities in Children with Angelman Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Angelman syndrome (AS) is a rare neurogenetic disorder that affects approximately 1 in 15,000 children – approximately 500,000 people worldwide. It is a major neurodevelopmental disorder characterized by severe developmental delay with significant intellectual disability, lack of oral language, motor, balance, and sensory impairments. While basic research and clinical trials are progressing, the scientific community is still searching for key biomarkers to assess significant improvements in individuals participating in clinical trials. Eye tracking has been widely used in the diagnosis of social perception abnormalities in children with autism spectrum disorder, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-02-25 |
| 40 | The Effect of Applied Group Training Given to Mothers with Children with Autism on Perceived Social Support, Depressive Symptoms and Self-compassion: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD), which can also be defined as a type of special need, is a congenital neurodevelopmental disorder whose symptoms are observed in early childhood. ASD, which has deficits in social communication and interaction as well as limited-repetitive behaviour patterns, starts in the early developmental stage and causes a significant impairment in areas of social functioning . A child with autism causes serious anxiety and depression in the family for many reasons, including the uncertainty of the diagnosis, the severity and duration of the disorder, … |
HAVVA KAÇAN; | 2025-02-15 |
| 41 | Networks Integrating Anxiety and Metabolism in Human Anorexia Nervosa, A Randomised Controlled Trial on Physiological and Psychological Responses to Caloric and Non-Caloric Meals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anorexia nervosa (AN) is known as the psychiatric disorder with the highest mortality rate as long-term calorie restriction causes medical complications and suicide risk. The ineffectiveness of pharmacological treatments increases interest in the etiopathogenesis of the disease. This study aims to examine the effects of caloric and non-caloric food intake on stress response, changes in brain network activity in AN patients and healthy volunteers, and examine whether these changes are related to caloric intake through neuroendocrine and psychological responses. The study will include 30 female AN patients aged 13-18 who are newly diagnosed and have not received any treatment, … |
OLOF LAGERLÖF; | 2025-02-15 |
| 42 | The Alama Project: Autism Outcomes and Neurobehavioral Markers in Young Children Born to Mothers With HIV in Kenya PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures to determine whether these can predict autism diagnoses in both children exposed to HIV and uninfected (CHEU) and children not exposed to HIV and uninfected (CHUU). |
REBECCA MCNALLY KEEHN; | 2025-02-11 |
| 43 | Pai.ACT: An Artificial Intelligence-Driven Chatbot-Assisted ACT Mobile Platform With Mental Health Triage – A Randomized Controlled Trial and Regional Service Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Parents of children with special needs in Hong Kong often face limited psychological support, which can negatively impact the child rehabilitation process and the well-being of parent-child relationships. To address this gap, we have developed Pai.ACT, the first deep learning-based mental health advisory system for parents. Pai.ACT features an AI chatbot that integrates the counselling principles of Acceptance and Commitment Therapy (ACT) through natural language processing, providing parents with a human-like voice-to-text experience. Using data from chatbot interactions, … |
YUEN YU CHONG; | 2025-02-10 |
| 44 | Mental Health, Intellectual and Neurodevelopmental Disorder Detection with Artificial Intelligence Models: Testing Speech-Based Machine Learning Algorithms for Clinical Assessment and Risk Stratification in Mental Health Presentations PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates whether AI-driven analysis of speech can accurately predict clinical diagnoses and assess risk for various mental or behavioral health conditions, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, bipolar disorder, generalized anxiety disorder, major depressive disorder, obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and schizophrenia. We aim to develop tools that can support clinicians in making more accurate and efficient diagnoses. |
JULIANNA OLAH; | 2025-02-04 |
| 45 | Effectiveness of A Zinc Oxide Adhesive Securement Device in The Fixation of Midline and Peripherally Inserted Central Catheters in Hospitalized Adult Patients: Randomised Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study in which a zinc oxide fixation device (a product that can help protect the skin) for catheters (polyurethane tubes inserted into a vein) will be tested to reduce catheter-related complications: catheter displacement, skin complications, phlebitis and pain.. |
FERRAN PADILLA NULA; | 2025-02-01 |
| 46 | Exploring Eye Vergence Markers in Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators study aims to evaluate the utility of eye vergence, an eye-tracking measure, as an indicator of visuo-spatial attention in children aged 4-17 years and adults, using computer-based eye-tracking tasks. Eye vergence, a binocular movement crucial for depth perception, has recently been linked to attentional control and neurodevelopmental conditions (NDCs) like ADHD and ASD. The investigators will work with children and adults from the CAN and Beckenham clinical centres to explore the relationship between eye vergence and diagnostic categories, potentially identifying subgroups with specific or overlapping attentional differences. This research may aid in the early detection of attention deficits, … |
ELIZABETH KILBEY; | 2025-02-01 |
| 47 | Evaluation of The Effects of Different Dietary Practices on Quality of Life and Eating Behavior in Children with Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the effects of gluten-free casein-free diet and feingold diet on gastrointestinal system (GI) symptoms , eating behavior and quality of life in children with autism spectrum disorder. Research questions are below: Is there a difference in the effects of a gluten-free-casein-free diet and the Feingold Diet on GI symptoms? Is there a difference in the effects of a gluten-free-casein-free diet and the Feingold Diet on eating behavior? Is there a difference in the effects of a gluten-free-casein-free diet and the Feingold Diet on quality of life? |
SIMGE GÜREL; | 2025-02-01 |
| 48 | Identifying The Prevalence of Complex Post-Traumatic Stress Disorder in Trauma-Exposed Children and Adolescents and Examining Related Factors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess the psychiatric evaluation of children and adolescents exposed to trauma in the outpatient clinic and to determine the prevalence of PTSD and Complex PTSD (CPTSD) diagnoses. Additionally, it aims to compare the clinical characteristics of children exposed to trauma who do not receive a PTSD diagnosis, those diagnosed with PTSD, and those diagnosed with CPTSD, as well as to examine the trauma history of their parents and the severity of their anxiety and depression. Furthermore, since there is no existing scale to assess CPTSD in children in our country, … |
BEYZA NUR KARAL; | 2025-01-30 |
| 49 | Milieu Teaching-AV (MT-AV Pilot): A Pilot Study to Assess The Feasibility of An Adaptation of Milieu Teaching for Infant Siblings of Autistic Children That Encourages Looking to The Mouth Related Papers Related Patents Related Grants Related Experts View Highlight: This project will look at whether a novel approach to language intervention that encourages looking to audiovisual speech cues for infants with autistic older siblings (Baby Sibs), who are highly likely be diagnosed with autism or developmental language disorder (DLD). This study will specifically look at (a) whether caregivers find this approach to be easy to implement in their homes, (b) whether they find this approach to be acceptable, and (c) whether caregivers use the taught strategies in interactions with their infants. |
JACOB I. FELDMAN; | 2025-01-30 |
| 50 | Motor-voice Assessment in Infants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants.. The main questions it aims to answer are: Identify voice factors among infants with newborn-detectable risk. Identify association between individual characteristics (Gestational age at birth, global function, motor-function) and voice factors. Examine unique features of voice production that are present in infants with high-risk for Cerebral Palsy (CP). Participants will be asked to upload a 3-minute videos of their child at term-age, 3.5-, … |
JILL HEATHCOCK; | 2025-01-28 |
| 51 | Plasma Oxytocin Changes in Response to Low-dose MDMA Vs. Placebo in Patients With Arginine Vasopressin Deficiency (Central Diabetes Insipidus) and Healthy Controls – The OxyMAX Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigator hypothesize that low-dose MDMA (3,4-methylenedioxymethamphetamine) will produce a sufficiently strong oxytocin stimulation in healthy controls and no relevant increase in patients. This study will confirm previously published data and provide important safety data with low-dose MDMA stimulation testing. |
MIRJAM CHRIST-CRAIN; | 2025-01-27 |
| 52 | Clinical Impact of Non-invasive Neurally Adjusted Ventilatory Assist in Very Preterm Infants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective observational study investigating the impact of NIV-NAVA on short-term clinical outcomes and long-term neurodevelopment in very preterm infants. |
JUYOUNG LEE; | 2025-01-20 |
| 53 | EVALUATION OF A COMMUNITY DRIVEN, EQUITABLE INTERVENTION FOR BLACK CHILDREN WITH AUTISM PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Findings from a group level assessment with caregivers of Black children with autism revealed barriers to equitable care and services (e.g., a lack of cultural representation among their child’s care team, caregiver stress, stigma, and uncertainty about services needed). The Autism Doula program was identified by the community to address the aforementioned barriers and provide culturally matched family navigation and social-emotional support while also acknowledging the unique experiences and values of caregivers of Black children with autism. Impact: The current project aims to assess the acceptability, feasibility, … |
CHILDREN’S HOSPITAL MEDICAL CENTER CINCINNATI | 2025-01-18 |
| 54 | Study on The Safety, Tolerability, and Preliminary Efficacy of Single Intrathecal Injection of AAV-MECP2 for The Treatment of Rett Syndrome Related Papers Related Patents Related Grants Related Experts View Highlight: Rett syndrome (RTT) is a serious neurodevelopmental disorder that has a significant impact on patients and their families. Patients suffer from severe social dysfunction and poor quality of life, and there is currently no effective treatment available. The MECP2 functional loss mutation is the clear pathogenic factor. In recent years, gene therapy has been applied in neuromuscular diseases such as SMA and has achieved good safety and effectiveness. Professor Qiu Zilong’s self-developed AAV-MECP2 gene therapy product for RTT was found to significantly improve disease symptoms in RTT model mice, … |
GUANGZHOU WOMEN AND CHILDREN’S MEDICAL CENTER | 2025-01-14 |
| 55 | Effects of The Structured Sherborne Developmental Movement Program on Sensory and Motor Performance and Functional Status in Children With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to investigate the effects of the Structured Sherborne Developmental Movement Program on sensory and motor performance and functional status in children with autism spectrum disorders. |
ELIF DILAN ATILGAN; | 2025-01-09 |
| 56 | Use of Eye Tracking to Aid in Autism Risk Detection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures. |
REBECCA MCNALLY KEEHN; | 2025-01-08 |
| 57 | Cera™ ASD Occluder Post-Market Clinical Follow-Up Study：A Multi-Center, Single-arm, Ambispective Post-Market Follow-Up Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this post-market study is to: * collect real-word clinical data and confirm the long-time safety and performance of the Lifetech Cera™ ASD Occluder * identify previously unknown side-effects |
LIFETECH SCIENTIFIC SHENZHEN | 2025-01-03 |
| 58 | Evaluation of The Risk of Developing Disordered Eating Behaviors or Eating Disorders in Children and Adolescents with Obesity Using A Digi-Physical Treatment Tool PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate the risk of developing disordered eating behavior or an eating disorder among children and adolescents with obesity who have used a digi-physical treatment tool with daily measurements conducted at home. The primary outcomes are to: * Evaluate the proportion of patients exhibiting documented signs of disordered eating behaviors during or after treatment (e.g., caloric restriction, skipping meals, binge eating). * Evaluate the proportion of patients diagnosed with an eating disorder (e.g., anorexia nervosa, bulimia nervosa, binge eating disorder) during or after treatment. Patients at Martina Childrens Hospital, Stockholm, Sweden, … |
PERNILLA DANIELSSON; | 2025-01-01 |
| 59 | The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on The Healing of Postoperative Pain and Periapical Lesions in The Treatment of Apical Periodontitis: Randomized Controlled Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to evaluate the effect of Mesenchymal Stem Cells (MSCs) isolated from the umbilical cord and exosomes derived from these cells on the success of the treatment in the regenerative endodontic treatment of necrotic open apex molar teeth. Regenerative endodontic treatment aims to disinfect root canals and revascularize pulp tissue. Our goals in this study are; obtaining umbilical cord-derived MSCs, obtaining exosomes derived from umbilical cord MSCs, selecting patients with molar teeth with necrotic open apex and periapical lesion, initiation of regenerative endodontic treatment and disinfection of root canals, … |
IPEK ERASLAN AKYUZ; | 2025-01-01 |
| 60 | Hybrid Effectiveness-Implementation Trial of An Executive Functioning Intervention for Children’s Mental Health Services PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to follow up on a prior project examining the impact of training therapists in an executive functioning intervention Unstuck and On Target (UOT) adapted for community mental health settings. Study aims are to test the clinical and implementation effectiveness of training mental health therapists in Unstuck and On Target, an executive functioning intervention, relative to Unified Protocol for Children, a transdiagnostic intervention for emotional disorders. This includes examining the implementation of Unstuck and associated outcomes (e.g., effective delivery, expanded use of Unstuck beyond autism, … |
KELSEY DICKSON; | 2024-12-15 |
| 61 | Randomized Control Trial of SCERTS (Social Communication, Emotional Regulation, Transactional Support) Program for Children with Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized control trial aims to assess the efficacy of the SCERTS intervention in children aged 3-6 years diagnosed with mild to moderate Autism Spectrum Disorder (ASD). The study evaluates the program’s impact on improving social communication skills, adaptive behavior, and reducing caregiver stress while enhancing parental quality of life. The intervention incorporates components of Social Communication, Emotional Regulation, and Transactional Support, tailored to cultural and contextual needs in Pakistan. The study will also validate translated and culturally adapted tools for program evaluation. The SCERTS model is a multidisciplinary, evidence-based intervention that focuses on enhancing social communication, emotional regulation, … |
AISHA SALEEM; | 2024-12-15 |
| 62 | Effectiveness of A Positive Psychology and Mindfulness Based App for Parents of Children with A Neurodevelopmental Disorder (NDD): Study Protocol of A Pragmatic Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: An app based on positive psychology and mindfulness to support the mental well-being of parents of children with a Neurodevelopmental Disorder (NDD) was developed and will be evaluated on effectiveness. |
KIM TONIS; | 2024-12-03 |
| 63 | Developmental and Epileptic Encephalopathy of Genetic Etiology: Natural History Through Reuse of Clinical Data / DEE-RETRO PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Developmental and Epileptic Encephalopathy (DEE) are a heterogeneous group of neurodevelopmental disorders linked to both epilepsy and its underlying etiology, independently of epileptiform activity. The creation of a database with retrospective follow-up of a large number of patients on a national scale will enable better knowledge of specific biomarkers, and thus a better classification and understanding of the natural evolution of DEE according to their etiology. This will enable better, more personalized therapeutic management of patients, depending on etiology and the presence or absence of these biomarkers. The investigators will also be able to draw up management recommendations, … |
PATRICK VAN BOGAERT; | 2024-12-01 |
| 64 | Improving Academic and Social Functioning in Middle-Schoolers With Autism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to test how well two group interventions work for middle-school children with Autism Spectrum Disorder (ASD). One of the interventions focuses on teaching parents and adolescent skills to help improve their social functioning and the other focuses on teaching parents and adolescents skills to improve organization, planning, and study skills. Eligible participants will be randomly (like a coin flip) assigned to attend one of the two interventions. |
LEANNE TAMM; | 2024-12-01 |
| 65 | EVALUATION of EARLY FAMILY and MULTIFAMILY INTERVENTION for YOUNG CHILDREN with AUTISM SPECTRUM DISORDERS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Collaborative early management of children under 30 months with autism spectrum disorder and their families in an ambulatory child psychiatry unit. |
PIERRE LECARPENTIER; | 2024-11-29 |
| 66 | Promoting Early Intervention Timing and Attention to Language PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study (PETAL: Promoting Early intervention Timing and Attention to Language) aims to determine the timing of intervention among infants with Increased Likelihood for Autism (ILA; at risk for autism by virtue of having an older sibling with autism) on communication and language outcomes at 24 months. Results of this study will determine when (9 vs 12 vs 15 months), and based on which measures (brain, language, … |
CONNIE KASARI; | 2024-11-25 |
| 67 | Intervention for Neurodevelopmental Support in Preterm Infants Using Responsive Parenting and E-health (INSPIRE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Research problem and specific questions More than 1000 very preterm infants (\< 32 weeks) are born every year in Sweden. They are at high risk of neurodevelopmental disabilities and mental illness throughout the lifespan. The overall purpose is to develop and evaluate a novel e-health intervention aimed at improving neurodevelopment (cognitive, motor, feeding, language, socio-emotional) of very preterm infants by supporting responsive parenting behaviours. The primary research question is whether the intervention improves child neurodevelopment up to 2 years. Further research questions relate to the emotional availability of parents and children, … |
UMEÅ UNIVERSITY | 2024-11-20 |
| 68 | Expediting Enrollment Into Autism-specific Intervention for Black Toddlers: A Telehealth-based Family Navigation Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess whether telehealth-based Family Navigation (FN) expedites enrollment (e.g., reduces time in days) in community-based autism intervention for Black toddlers under the age of 4 after their initial diagnosis of autism. The main questions it aims to answer are: Does Family Navigation decrease the time to initiation of intervention for Black toddlers with autism? Does Family Navigation improve developmental outcomes at 18 months post-diagnosis of autism? Does Family Navigation improve caregiver well-being? Caregivers in the Family Navigation condition will receive 4 research-based individual sessions with a trained navigator to support them in identifying and enrolling in recommended autism early intervention services. All navigation sessions will be delivered virtually via phone/Zoom. Researchers will compare participants who receive family navigation to participants who receive the standard of care (educational materials) to see if family navigation outperforms the standard of care. |
KELLY CARAVELLA; | 2024-11-19 |
| 69 | The Efficacy of Parent Management Training to Treat Irritability PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to see if 12 sessions of a Parent Management Training program can treat irritability in children aged 10-14 years old. The main question it aims to answer are: * Can a Parent Management Training for parents reduce anger outbursts and cranky moods in their children? * Can Parent Management Training be done in an outpatient clinic and do parents like it? Up to 18 families can join this study. This study will be used to set up a larger study in the Fall of 2025. Parent participants will complete 12 sessions of Parent Management Training for Irritability. Each session will be 45-55 minutes weekly. They will also participate in the assessments of their child before, during and after treatment. Child participants will do assessments before, during and after the Parent Management Training treatment. |
JOEL STODDARD; | 2024-11-18 |
| 70 | Emergent Bilinguals: The Relationship Between Child Language Proficiency and Language of Treatment on The Outcomes Children with Developmental Language Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Of the 12 million children in the USA growing up bilingual, about 1 million experience Developmental Language Disorder (DLD), a disorder in language learning and use. Currently there is no guidance for speech language pathologists (SLPs) as to the language of intervention for emergent Spanish-English bilingual children with DLD. This project will examine the relationship between language proficiency and the language of intervention, considering monolingual intervention (Spanish or English) and interleaved Spanish-English intervention with the goal of improving language outcomes and thereby strengthening long-term academic achievement |
UNIVERSITY OF HOUSTON | 2024-11-11 |
| 71 | Evaluation of Sustained Endogenous Attention Deficits in Attention Deficit Hyperactivity Disorder: Validation of A Computerized Neuropsychological Test. PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Subjects with ADHD may exhibit deficits in sustained internal attention. The Sustained-Paced Finger Tapping test was recently developed and experimentally used in international literature to assess sustained internal attention in typically developing children. This clinical study has several objectives: 1) to assess the presence of internal sustained attention deficits in children with ADHD through the Sustained-Paced Finger Tapping; 2) to evaluate the discriminant and ecological validity of the Sustained-Paced Finger Tapping. |
IRCCS EUGENIO MEDEA | 2024-11-11 |
| 72 | Further Delineation of The De Santo Shinawi Syndrome Phenotype Using A Series of Individuals Carrying A Pathogenic Variant of The WAC Gene PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this retrospective, multicenter study would be to extend the phenotypic spectrum of DeSanto Shinawi Syndrome and improve the knowledge of its evolution. To this end, the investigators would like to issue a call for international collaboration in order to create a series of new genetically diagnosed patients, not yet described in previous publications, and with a larger number of individuals evaluated in a single study. One of the aims would be to establish a set of standardized clinical and paraclinical examinations to be carried out at diagnosis and for follow-up of affected patients. This would enable patients, … |
FLORIAN CHERIK; | 2024-11-07 |
| 73 | Expanding Autism Diagnostic Biomarkers to Kenya PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures. |
REBECCA MCNALLY KEEHN; | 2024-11-07 |
| 74 | Psilocybin for Treatment-Resistant Depression in Autism: A Pilot Trial with Pre-Post Brain and Cognitive Measurement to Understand Mechanism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We propose a first-of-its-kind open-label clinical trial to investigate the feasibility, tolerability, and safety of administering psilocybin in autistic adults with treatment-resistant depression (TRD). In this study, 20 participants (intellectually able and fluent-speech adults) with autism and co-occurring TRD will receive around 20 hours of manualized psychotherapy that has previously been used with psilocybin (Agin-Liebes et al., 2020). They will also receive psilocybin at 2 different time points, firstly a safety dose of 10mg, … |
CENTRE FOR ADDICTION AND MENTAL HEALTH | 2024-11-01 |
| 75 | Effects Of Ankle Weighted Cuffs Training on Kinesthetic Awareness and Toe Walking in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorders (ASD) are a diverse group of conditions. They are characterized by some degree of difficulty with social interaction, communication and behaviors. Kinesthetic awareness can be defined as how we sense our body and the way it moves. This person might have difficulty understanding where their body is in relation to other objects, thus appearing clumsy, knocking things over, dropping items or misjudging personal space and thus standing too close to others. |
HAFIZA RASHIDA MAQBOOL; | 2024-10-28 |
| 76 | Little Journey – Usability Study Related Papers Related Patents Related Grants Related Experts View Highlight: Assessment of the usability/ acceptability of the Little Journey app with children aged between 3-12 years old with a diagnosis of autism spectrum disorder (ASD) and experience of attending hospital for a procedure, and their parent (or carer), using a test scenario and semi-structured interview. |
LITTLE JOURNEY | 2024-09-28 |
| 77 | Effects of Muscle Energy Technique With and Without Stationary Cycling on Toe Walking With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In Autism spectrum disorder (ASD) is a developmental disability caused by differences in the brain. People with ASD often have problems with social communication and interaction, and restricted or repetitive behaviors or interests. People with ASD may also have different ways of learning, moving, … |
RNA MOHAMMAD IQBAL; | 2024-09-26 |
| 78 | Comparative Effects of Individual and Grouped Sensory Perceptual Motor Training on Gross Motor Skills and Quality of Life in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism is the most prevalent disorder as it affects attention, awareness, cognitive development, social development, and emotional aspects too. It is one of the comprehensive developmental disorders in the early stage, which is characterized by weak social learning and communication, limited activities, interests, learning, insufficient imaginative and stereotypical thinking or non-functional thinking of movements and verbalities. A lack of sensory perception leads to a leading autistic child's sensitivity to sensory stimuli or weak sensitivity and the child is not aware of the surrounding environment. |
SARA SATTAR; | 2024-09-26 |
| 79 | Efficacy of LEGO Therapy for Adolescent with Level 1 Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if LEGO therapy can enhance social skills in children aged 10-14 diagnosed with high-functioning Autism Spectrum Disorder. The main questions it aims to answer are: Does LEGO therapy improve social communication and interaction skills in children with Autism Spectrum Disorder? Do children show behavioral improvements in social skills after participating in LEGO therapy? Researchers will compare children receiving LEGO therapy to a control group (who will not receive LEGO therapy but continue their usual treatments) to see if LEGO therapy leads to greater improvements in social skills. Participants will: Complete behavioral tasks, including a LEGO construction test, at the beginning (T0) and after 3 months (T1). Attend weekly LEGO therapy sessions for 90 minutes, over the course of 3 months (12 sessions). Complete questionnaires about social behaviors, both parents and children, at T0 and T1. |
ANTONIO NARZISI; | 2024-09-20 |
| 80 | Deep Brain Stimulation for The Treatment of Severe Refractory Self-Injurious Behaviour in Children With Autism Spectrum Disorder: A Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Deep Brain Stimulation for the Treatment of Severe Refractory Self-Injurious Behaviour in Children with Autism Spectrum Disorder: A Randomized Trial To evaluate the effectiveness of deep brain stimulation (DBS) of the nucleus accumbens for the treatment of severe refractory, repetitive self-injurious behavior (SIB) in children with Autism Spectrum Disorder. Secondary objectives are to examine the effects of DBS on subtypes of SIB through functional analysis. |
GEORGE IBRAHIM; | 2024-09-11 |
| 81 | Being A Parent with An Autism Spectrum Disorder: Strengths, Challenges and Adaptation of A Mentalization-based Parenting Program PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In many individuals, Autism Spectrum Disorder (ASD) is recognized and diagnosed late in adolescence or even in adulthood, despite the presence of long-standing impairments and distress. One area that has received little attention so far is research and interventions in clinical practice that relate to the experienced realities of parenthood for autistic adults or offer support in this context. The few existing research findings in this field suggest that parents with ASD might face specific challenges. At the same time, there is a lack of empirical research on the experiences autistic adults have with parenthood, … |
JOHANNES BOETTCHER; | 2024-09-01 |
| 82 | Pilot Randomized Trial of The RUBI Program for Families of Autistic Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate if a redesigned version of the RUBI parenting intervention can reduce challenging behaviors and improve adaptive skills in autistic adults with co-occurring challenging behaviors. The main questions it aims to answer are: – Is the redesigned RUBI intervention feasible and acceptable for autistic adults and their families? – Does the redesigned RUBI intervention reduce challenging behaviors and enhance the quality of life for autistic adults? – Researchers will compare the redesigned RUBI intervention to an active control group, Introduction to the Science and Lived Experience of Autism (ISLEA), … |
DAINA M TAGAVI; | 2024-09-01 |
| 83 | Effect of Web-Based Animated Training Given To Mothers With Children Between 18-36 Months on The Awareness Level: Mother-Child School PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Toilet training is the training that helps children gain control of their urine and stool while they are asleep and awake, and to recognize that they need to go to the toilet and relieve themselves without being reminded or helped.Toilet training is the training that helps children gain control of their urine and stool while they are asleep and awake, and to recognize that they need to go to the toilet and relieve themselves without being reminded or helped.Weaning is the gradual cessation of breastfeeding. For most mothers and their babies, … |
EDA GULBETEKIN; | 2024-09-01 |
| 84 | Investigating The Potential Efficacy, Feasibility, and Acceptability of Parent Telecoaching Intervention on Children With Autism and Their Parents in Palestine: A Mixed-Method Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In Palestine, children with autism spectrum disorder and their parents face difficulties in receiving needed early intervention and rehabilitation services due to a lack of specialized professionals and centers, as well as cultural, political, geographical, and financial barriers. Parents also face difficulties in raising their children with autism in their homes as they lack knowledge about the disorder and the best interventions that can be used to help these children. Parent telecoaching intervention, or what is called (distance coaching via technology) can help parents and their children with autism. However, … |
MOHAMMAD SALAHAT; | 2024-09-01 |
| 85 | Efficacy of Physical Activity for The Management of Stereotyped Behavior and Anxiety in Children with Autism Spectrum Disorder: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of the study is to investigate whether physical activity can significantly manage stereotyped behavior and anxiety in children diagnosed with Autism Spectrum Disorder (ASD). The study aims to contribute to the existing literature by providing robust evidence on the efficacy of Physical Activity intervention for ASD, which could inform clinical practices and improve treatment outcomes. |
SABA RASHID; | 2024-08-21 |
| 86 | Klinefelter Syndrome – The Effect of Testosterone Treatment in Puberty. A Randomized, Double-blind Placebo-controlled Intervention Study: ‘The TiPY Study’ PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to study the effect of testosterone replacement therapy during puberty in boys with Klinefelter syndrome (KS, 47,XXY). The main questions to answer are how treatment with testosterone will affect body fat mass, lipid and glucose metabolism, growth and body proportions, bone mineralization as well as effects on neurocognitive development and emotional and social difficulties. Participants will be randomized to two years treatment with testosterone or placebo. |
LISE AKSGLÆDE; | 2024-08-15 |
| 87 | Discerning The Abnormal Functional Connectivity Involving The Social Reciprocity Network in Autism Spectrum Disorder and The Impact of Transcranial Magnetic Stimulation in Mitigating The Abnormalities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is no consensus regarding the neurological substrate underpinning ASD. The investigators describe the novel concept of social reciprocity network and hypothesize that aberrant connectivity/oscillatory patterns affecting this network contribute to the core deficits in ASD. The overarching goal of this trial is to explore abnormalities involving the neuronal connectivity and oscillatory patterns within the social reciprocity network and to elucidate the role of modulating this network via rTMS in improving the above measures and social cognition in ASD. Quantitative electroencephalography (QEEG) coherence and spectral power analysis are reliable measures of neuronal connectivity and dynamics. The investigators aim to study the QEEG coherence/spectral power analysis to explore the neuronal dynamics affecting the social reciprocity network in ASD. |
MITRA ASSADI; | 2024-08-15 |
| 88 | A Multi-center, Randomized, Assessor-blind, Superiority, Confirmatory Clinical Trial to Assess Safety and Efficacy of Cognitive Therapy Software ‘NDTx-01’ for Improving Social Awareness and Interaction in Children and Adolescents With Autism Spectrum Disorder (ASD) or Social Communication Disorder (SCD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to demonstrate the superiority of the treatment of cognitive therapy software ‘NDTx-01’ compared to TAU (Treatment-As-Usual). |
YOO-SOOK JOUNG; | 2024-08-14 |
| 89 | Culturally Adapted Play-Based Behavioural Intervention Among Children With Autism Spectrum Disorder in Semi-Rural Tamil Nadu: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compared Culturally Adapted Play-Based Behavioural Intervention (PPBI) and Applied Behaviour Analysis (ABA) for children with Autism Spectrum Disorder (ASD) in semi-rural Tamil Nadu through a double-blinded randomized controlled trial with 56 participants. The PPBI approach integrated traditional Tamil games such as Paandi (hopscotch), Kuzhi Thanda (hole-and-peg game), and Paramapadham (snakes and ladders) to encourage social interaction, cooperative play, motor skill development, and emotional self-regulation. Activities were structured to progress through various developmental goals, including turn-taking, gesture-based communication, sensory-motor coordination, language expression, peer collaboration, and real-life scenario practice. Additionally, storytelling, music-based play, … |
MADHANRAJ SEKAR; | 2024-08-05 |
| 90 | Natural History with Focus on Oncological Risk Evaluation in Pediatric Patients with PTEN Pathogenic Variants – Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study in pediatric patientis carryng PTEN pathogenic variants aimed to define oncological risk in children and provide a deeper insight of the clinical course, establishing an updated follow-up protocol. |
FONDAZIONE I R C C S ISTITUTO NEUROLOGICO CARLO BESTA | 2024-08-01 |
| 91 | Participatory Research for Suicide Prevention in Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to pilot test a new educational intervention for organization members focused on suicide prevention for autistic people. The main questions it aims to answer are: – Does participating in the intervention increase participants’ knowledge, skills, and actions to support suicide prevention for autistic people? – What feedback do participants have to help improve the intervention? Participants will: – engage in a four-part virtual educational intervention – answer questions via online survey before, after, and 3-months after the intervention – participate in an optional interview to provide feedback |
ANNE KIRBY; | 2024-08-01 |
| 92 | Piloting Eye Movement Desensitization and Reprocessing (EMDR) in People Living with HIV and Trauma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Eye Movement Desensitization and Reprocessing therapy is a time-limited trauma-response therapy that treats symptoms of stress that result disturbing life experiences. Eye Movement Desensitization and Reprocessing therapy has been used to treat trauma-related symptoms for people living with HIV. People living with HIV tend to experience higher psychiatric morbidity rates of depression, anxiety, and post-traumatic stress symptoms than the general population. However, even with case studies of Eye Movement Desensitization and Reprocessing therapy on people living with HIV, … |
BETHANY RHOTEN; | 2024-07-29 |
| 93 | ADAPT: Approach to Dance for Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be a randomized trial that will examine the impact of a recreational ballet program on children with autism spectrum disorder (ASD). The research team are primarily interested in assessing changes in motor skills with secondary objectives focused on the social, psychological, and behavioral effects. The study will aim to collect data from 24 participants with ASD. Participants must be 7-12 years old, have a confirmed diagnosis of ASD, … |
ALEXANDER KOLEVZON; | 2024-07-17 |
| 94 | Preliminary Efficacy and Feasibility of Using NeuroCytotron in The Treatment of Autism Spectrum Disorder: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Preliminary Efficacy and Feasibility of Using NeuroCytotron in the Treatment of Autism Spectrum Disorder |
LORENZO R MORALES MANCIAS; | 2024-07-15 |
| 95 | The Modulatory Effects of Oxytocin and Vasopressin on Delta-beta Cross-frequency Coupling PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the study is to investigate whether intranasal oxytocin and vasopressin have effects on delta-beta cross-frequency coupling under resting-state and task conditions. |
SHUXIA YAO; | 2024-07-01 |
| 96 | Effect of Combined Music and Taekwondo Training on The Psychological and Physical Condition of Children with Autism Spectrum Disorder: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to evaluate the effect of combined music and taekwondo training on the mental and physical condition of children with autism spectrum disorder. Participants will be asked to do combined music and taekwondo training or taekwondo training alone to evaluate if the combined training is better than the taekwondo training alone on mental and physical performance for children with autism spectrum disorder. |
CLARE CW YU; | 2024-06-30 |
| 97 | Iterative Redesign of A Multifaceted Implementation Strategy for A School-based Behavioral Skills Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The increased prevalence of autism spectrum disorder (1 in 36 youth) in the United States along with the exorbitant cost of care of supporting one autistic individual with and without intellectual disability across their lifespan ($2.4 and $1.4 million, respectively) creates a sense of urgency to improve outcomes for autistic youth. Schools are the primary setting in which autistic children receive intervention. Despite a growing array of evidence-based interventions (EBI) such as behavioral management, … |
JILL LOCKE; | 2024-06-20 |
| 98 | Assessing A Mobile App-based Mindfulness Training to Improve Mental Health of Caregivers of Children With Autism Spectrum Disorder in Rural Areas PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to investigate the effectiveness of a mobile app-based mindfulness program in improving the mental well-being of caregivers with a child diagnosed with autism spectrum disorder (ASD) who live in rural areas of Maine. The primary question the investigators aim to answer is whether this mindfulness intervention can reduce stress and anxiety in these rural caregivers of children with ASD. Participants in the trial will engage in a 30-day mindfulness program that they can complete over a maximum of 60 days. During this time, … |
KAHSI A. PEDERSEN; | 2024-06-15 |
| 99 | Autistic Eye Contact? A Hermeneutic Phenomenological Multicenter Study on Experiences With Eye Contact Between Adults With and Without Autism Spectrum Disorder With Use of Semi-structured Interviews. Using Semi-structured Interviews, The Experiences of People With and Without Autism Regarding Eye Contact Were Made Clear. The Topic List for These Semi-structured Interviews Was Developed in Co-design With People With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research explored both breadth and depth of the experiences with eye contact in adults with and without ASD. A hermeneutic phenomenological multicenter design was used in which 15 adults with ASD and 15 adults without ASD were interviewed, using semi-structured interviews. Analyses using Multisite Qualitative Analysis (MSQA) and PRICE-model for saturation. |
JOS BOER; | 2024-06-03 |
| 100 | Prevalence and Healthcare Consumption of ASD Patients Using French Medico-administrative Data (SNDS) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is one of the neurodevelopmental disorders described in the DSM5 (American Psychiatric Association, 2013). This heterogeneous syndrome appears in childhood and persists throughout life with different developments from one individual to another. It is clinically characterized by the combination of deficits in social communication with restricted and repetitive behaviors. The prevalence of ASD has seen a significant increase over the last 10 years, with estimates varying greatly from one country to another, ranging from 4.2/1,000 in France to 31/1,000 in Iceland. In France, … |
CATHERINE QUANTIN; | 2024-06-01 |
| 101 | A Randomized Controlled Study to Evaluate Social Skill Treatment Options in Children With Autism Using VR Technology PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to compare and learn about Virtual Reality (VR) in children with autism/Autistic children. The main question it aims to answer is: • Does the Floreo VR clinical product show clinical improvement in autism symptoms? Participants will engage the VR product for twice a week for twelve weeks. They will be randomized to either the Floreo Clinical Product or a VR Control group experience. Researchers will compare the two groups to see if there is an effect on learning specific skills and behaviors. |
SUZANNE GOH; | 2024-05-31 |
| 102 | Social Cognition in Major Depression and Autism Spectrum Disorder: Cortical Excitatory-inhibitory Imbalance and Neuromechanism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the brain physiological responses in depression and autism. The main questions aim to answer are: 1. Comparing the ratios of cortical excitation and inhibition among four groups: autism group, autism with depression group, depression group, and normal control group using Transcranial magnetic stimulation and electroencephalography (TMS-EEG). This study explores the relationship between the ratios of cortical excitation and inhibition and the severity of clinical symptoms. 2. Comparing the brain inflammation among four groups: autism group, autism with depression group, depression group, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2024-05-28 |
| 103 | Investigating The Effects of Executive Functions and Social Cognition on The Relationship Between Autistic Traits and Mental Health PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to analyze the effects of executive functions (EFs) and social-cognitive abilities on the associations between autistic traits and mental health indicators (depression, anxiety, and stress). Moreover, the study will produce online training modules for executive functions and social cognition, aimed at reducing the likelihood of adverse mental health outcomes in individuals with and without elevated autistic traits. Therefore, four main hypotheses will be addressed: 1. Revealing the mediating role of executive functions (cognitive flexibility, inhibitory control, and working memory) will help predict the association between autistic traits and mental health symptoms (anxiety, depression, … |
DILRUBA SÖNMEZ; | 2024-05-20 |
| 104 | The Effect of Vestibular and Proprioceptive Exercise Practices on Hyperactivity Levels in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the effect of vestibular and proprioceptive exercise practices on the hyperactivity level in children with autism spectrum disorder. |
ÖĞR. ÜYESI ÖMER ŞEVGIN; | 2024-05-15 |
| 105 | Utility of NESA Microcurrents in The Treatment of Sleep Disturbances, Disruptive Behaviours of Children With Autism Spectrum Disorders and in The Quality of Life of The Family Unit PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The term or definition of Autism Spectrum Disorder (ASD) defines a pervasive neurodevelopmental disorder in which deficits in communication and social interaction, altered sensorimotor behaviours, repetitive, restricted and stereotyped interests and activities are observed. One of the disorders most frequently associated with ASD, and which most affects the quality of life of the child and his or her family, is sleep disorders; it is estimated that between 50 and 80 percent of children with ASD present this alteration and generally continue to suffer from it in adolescence and adulthood; … |
ANÍBAL BÁEZ SUÁREZ; | 2024-05-13 |
| 106 | Comparison of Neuromuscular and Aquatic Exercise Programs on Fall Risk and Physical Function in Geriatrics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: The aim of this study is to compare neuromuscular and aquatic Exercise programs on fall risk and physical function in geriatrics. Methods: As a result of the power analysis (G-Power), 36 participants are planned to be included in this study Block randomization will be used to divide participants into 2 groups, each with at least 18 participants: Group 1 (NE Group) and Group 2 (AE Group) (Randomizer.org). NE (Neuromuscular Exercise) group will participate in a 12-week exercise program consisting of sensorimotor system training, postural stability and control, global and local joint stabilization, balance training, muscle strength, breathing, … |
OZUM CETINKAYA; | 2024-05-04 |
| 107 | Oxytocin Administration to Therapists and Its Effects on Patient-perceived Attunement and Responsiveness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years there is a great interest in the possible role of Oxytocin (OT) as a facilitator for enhancing psychotherapeutic processes in patients with mental illnesses. Specific studies explored OT administration to patients, and the effect on psychotherapy on interaction within the therapeutic dyad. Nonetheless, studies exploring OT’s effects of the therapists’ side of the therapeutic dyad on the psychotherapy session and outcome, have not been conducted. The current study aims to assess the effect of OT administration to the therapists of psychiatric outpatients, … |
SHALVATA MENTAL HEALTH CENTER | 2024-05-01 |
| 108 | Influence of Rhythm and Interpersonal Relationship on Gait Parameters in Children with Autism Spectrum Disorder: A Controlled Intervention Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) affects social communication and motor coordination, with less synchrony with others and atypical gait patterns. Relationship with the adult or speed modify gait parameters in children diagnosed with ASD between 4 and 6 years old. Methodology: a cross-sectional observational design was carried out. The aim of this study was to analyze gait pattern variations in children with ASD in different speed conditions and modifying the social environment. |
ESTRADA BARRANCO; | 2024-05-01 |
| 109 | A Comparative Study Between General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the present study is to compare between general anesthesia versus sedation with dexmedetomidine and ketamine with local infilteration at the catheter insertion site in pediatric patients undergoing transcutaneous closure of atrial septal defect on hemodynamic changes. |
AYA EBRAHIM ABDELHAFEZ MASHAL; | 2024-05-01 |
| 110 | Investigation of Oral Structural and Functional Problems in Children With Autism Secondary IDs: PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to examine oral structural and functional problems in children with autism. |
AYŞE KÜBRA ŞAHAN; | 2024-04-11 |
| 111 | Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder Using Transcranial Magnetic Stimulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations of others (also known as mentalizing) in young adults with autism. The main question it aims to answers is can stimulation of the right temporoparietal junction can change brain activity related to mentalizing during social interaction in the stimulation area and other brain areas connected to it. Researchers will compare results to a group of individuals without autism to see if the patterns of neural activity change are similar between the groups. Participants will undergo assessment of their clinical traits and social skills and baseline MRI scan. They will attend three additional visits that include TMS session and functional MRI scans before and right after TMS. |
VAUGHN STEELE; | 2024-04-03 |
| 112 | Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized trial is to determine efficacy of dexmedetomidine in improving quality of recovery in pediatric patients undergoing interventional catheter closure of ASD while maintaining the hemodynamic parameters. Additionally he stress reducing effects of dexmedetomidine will be investigated in this population . The main questions it aims to answer are: Does Dexmedetomidine maintain stable hemodynamics in pediatric patients undergoing transcatheter ASD Closure while improving their quality of recovery? Does dexmedetomidine prolong duration of recovery and time to extubation in pediatric patients ? Does dexmedetomidine exert stress reducing properties in this population? Participants will: Either be administered Dexmedetomidine in a loading/maintenance regimen or a placebo, with hemodynamics being monitored at the baseline, intraoperatively and postoperatively, with recovery time and quality of recovery especially emergence delirium being monitored. Stress hormone levels will be sampled at baseline and postoperatively. |
MOHAMED AHMED ADEL OKASHA; | 2024-04-03 |
| 113 | Translational Biomarkers and Therapeutic Development for Very Young Children Diagnosed with Autism Spectrum Disorder and Co-occurring Anxiety PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A within-subjects design will be used for this preliminary investigation of four biomarkers across two contexts of use: prediction of treatment response (i.e., stratification) and quantification of response (i.e., change). |
SUSAN FAJA; | 2024-04-02 |
| 114 | Repetitive Transcranial Magnetic Stimulation Guided By Personalized Brain Functional Sectors (pBFS) for Low-Functioning Autism Spectrum Disorder: A Multi-center, Randomized, Sham-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this trial is to assess the efficacy and safety of precision neuromodulation for alleviating core symptoms in patients with autism spectrum disorder (ASD) who also have intellectual or developmental delay. The neuromodulation will be administered using intermittent theta burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC), guided by personalized Brain Functional Sector (pBFS) technology. |
CHANGPING LABORATORY | 2024-04-01 |
| 115 | Development of Prosocial Behaviors and Related Brain Network in Infants of High and Low Risk of ASD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare the developmental trajectories of prosocial behaviors and functional network connections in infants and toddlers at high and low risk of autism spectrum disorder (ASD). The main questions it aims to answer are what the differences in prosocial behaviors and related brain network connections between infants/toddlers at high and low risk of ASD are. Participants will receive developmental and social communicational assessments (Griffiths Mental Developmental Scales, Peabody Developmental Motor Scales, The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist), resting-state EEG and MRI in a natural sleeping state. |
XIU XU; | 2024-04-01 |
| 116 | Efficacy of Oral Midazolam for Sedation and Amnesia in Preschool Children Undergoing Dental Procedures: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dental anxiety frequently impedes effective dental care in pediatric patients. This study aimed to compare the efficacy and safety of two doses (0.3 mg/kg and 0.6 mg/kg) of oral midazolam for sedation and amnesia in preschool children undergoing dental procedures. Methods: This prospective, double-blind, randomized controlled trial included 80 children aged 3-6 years with dental anxiety. Participants were randomly assigned to receive oral midazolam at either 0.3 mg/kg or 0.6 mg/kg. Sedation efficacy, onset time, procedure duration, cooperation level (Houpt Behavior Rating Scale), recovery time, amnesia at 12 hours, 24 hours, and one week, as well as adverse events, … |
DUC NGUYEN MINH; | 2024-04-01 |
| 117 | The Effect of Psychoeducation on Adult Siblings of People With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to apply a psychoeducational program in adult siblings of people with ASD as a means to provide knowledge related to the disorder and improving their quality of life. The psycho-educational program will be implemented in adult siblings of people with ASD and its effectiveness will be assessed. Participation in this program is expected to contribute in the improvement of the quality of life of the participants, their siblings with ASD and those related to them. No risk is identified. |
CHARALAMPOS DEPASTAS; | 2024-03-28 |
| 118 | Oral Health Implications of Dietary Preferences in Autistic Paediatric Population: A Cross-Sectional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to explore how dietary habits affect oral health in children with autism. By examining a cross-section of the autistic paediatric population, the research seeks to identify patterns or specific dietary preferences that may contribute to or mitigate oral health issues. This observational study does not intervene in participants’ diets but observes existing habits and their oral health outcomes, aiming to provide insights that could guide better dietary recommendations and oral health practices for children with autism. |
SUNIL KUMAR VADDAMANU; | 2024-03-25 |
| 119 | Effects of The Probiotic K11-tmax on Symptoms and Inflammatory Markers in Children With Autism Spectrum Disorder PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The research is characterized as a randomized, double-blind clinical trial (phase III) in which administered the probiotic K11-T (with and without added amino acids, fatty acids and vitamins) to children between 3 and 11 years old with Autism Spectrum Disorder – ASD, being subsequently assessed outcomes related to inflammatory markers and neuropsychiatric and sociopedagogical criteria. To this end, the study will create three groups, one of which will be a control group, which will receive a placebo, the other will receive the probiotic without micronutrients and another will receive the probiotic with added nutrients. |
DEIVIS DE OLIVEIRA GUIMARAES; | 2024-03-22 |
| 120 | Additional Effects of Vestibulo-Ocular Reflex Exercises to Improve Balance and Reduce Stimming in Adolescents With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder is a neurodevelopmental disorder that encompasses a number of disorders specifically affecting social skills, Communication and present with Rapid repetitive behaviors. Autism spectrum disorder also presents with inability of body to process sensory information which can causes symptoms such as balance deficits, sensitivity to certain sounds or an exaggerated reaction to a normal stimulus. Autism spectrum disorder can affect the quality of life of an individual to a severe extent. This disorder due to sensory processing deficits also shows difficulty in motor planning, … |
AYESHA AFRIDI; | 2024-03-20 |
| 121 | The Effects of Sensory-Motor Integration Exercises on Sensory Processing and Balance in Children With Autism Spectrum Disorder: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial evaluates the effectiveness of a 16-week structured sensory-motor integration exercise program compared to conventional therapy (Applied Behavior Analysis and massage therapy) in improving sensory processing abilities and balance in children aged 6-12 years diagnosed with Autism Spectrum Disorder (ASD). Outcomes are measured using the Short Sensory Profile and Berg Balance Scale at baseline and after 16 weeks of intervention. Findings aim to demonstrate the clinical utility of sensory-motor integration exercises in enhancing functional outcomes for children with ASD. |
MOHAMED ALY; | 2024-03-13 |
| 122 | A Pilot Study to Develop A Behavior-based Screening Protocol for Early Diagnosis of Autism Spectrum Disorders PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to collect basic data to develop a tool for early screening of autism spectrum disorder (ASD) in children and adolescents through eye tracking and motion analysis. |
MINYOUNG KIM; | 2024-03-01 |
| 123 | SkillTalk: Using Streaming Video for Young Adults With Autism Spectrum Disorder to Build Microskills to Develop and Sustain Relationships for Healthy and Independent Living Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effectiveness of using a Microskills video training library for young adults, aged 18-28, with autism spectrum disorder (ASD) to enhance their skills in developing and maintaining healthy relationships. The main questions it aims to answer are: – Does using SkillTalk increase autistic young adults skills in the communications skills that are demonstrated in the video curriculum (skills: resolve conflict, compromise, give feedback)? – Does using SkillTalk increase reported confidence and satisfaction in communication and relationship skills? – Does using SkillTalk increase interpersonal competence? – … |
REGINA FIRPO-TRIPLETT; | 2024-03-01 |
| 124 | Clinical Spectrum of Infants of Diabetic Mothers , in Neonatal Intensive Care Unit of Assiut University Children’s Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Determine spectrum of clinical presentations and complications associated with maternal diabetes mellitus in their newborns attending and admitted to Neonatal Intensive Care Unit of Assiut University Children’s Hospital. |
DINA NASSER MAHROUS DANIAL; | 2024-03-01 |
| 125 | Effectiveness of Lidocaine Injection on Stellate Ganglion in Pediatric Patients With Autism Spectrum Disorder: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore efficacy of stellate ganglion block Children with Autistic Disorder. The main question it aims to answer is: Can stellate ganglion block improve the Autistic Disorder in children? Children with Autistic Disorder will be divided into the control group and experimental group evenly. All the patients were provided with routine therapy, while the patients in the experimental group were given stellate ganglion block. The Childhood Autism Rating Scale of the two groups of patients before and after treatment are evaluated. |
MUHAMMAD | 2024-03-01 |
| 126 | Exploring The Effectiveness of Dance As An Intervention to Promote Social-Emotional Health Within The Everyday Lives of Children With ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will explore the effectiveness of dance as an intervention to promote social-emotional health within children with ASD. |
JULIE KUGEL; | 2024-03-01 |
| 127 | Stellate Ganglion Block in Children With Autistic Disorder: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore efficacy of stellate ganglion block Children with Autistic Disorder. The main question it aims to answer is: Can stellate ganglion block improve the Autistic Disorder in children? Children with Autistic Disorder will be divided into the control group and experimental group evenly. All the patients were provided with routine therapy, while the patients in the experimental group were given stellate ganglion block. The Childhood Autism Rating Scale of the two groups of patients before and after treatment are evaluated. |
COPKA SONPASHAN; | 2024-03-01 |
| 128 | Fecal Microbiota Transplantation for Gastrointestinal, Autistic, Emotion, and Behavior Symptoms of Patients With Autism Spectrum Disorder and Gastrointestinal Problems: A Preliminary Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the efficacy of fecal microbiota transplantation on the gastrointestinal symptoms, autistic symptoms and emotional behavior symptoms of patients with autism spectrum disorder, and investigate the relations between the brain-gut axis, cytokines and autism spectrum disorder. Fecal microbiota transplantation have the potentials to improve intestinal microbiota composition, regulate immunity, and then improve gastrointestinal symptoms, autistic symptoms, emotional behavior symptoms and sleep of children with autism spectrum disorder. Early intervention at school-age may even benefit development, improve cognition and prognosis. |
WEI-CHIH CHIN; | 2024-03-01 |
| 129 | Autism Spectrum Disorder and Attachment. An Explorative Study of Attachment Styles in Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study examines the relationship between attachment and autism spectrum disorder (ASD) in adults. |
STEPHANIE BOHNEN; | 2024-03-01 |
| 130 | Effects of Rhythmic Balance Auditory Vision Training And Strength Training On Motor Function And Cognition In Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism, a complex neurodevelopmental disorder that is marked by limited interests, and challenges in communication and social interactions and problem includes difficulties in understanding and responding to social cues, repetitive behaviors, intense focus on specific interests, and challenges with verbal and nonverbal communication. Rhythmic Balance Auditory Vision Training (RBAVT) a therapeutic approach which helps in improving coordination and balance in individuals with various neurological conditions. Strength training enhance physical health and muscle development. Thus, … |
RIPHAH INTERNATIONAL UNIVERSITY | 2024-02-25 |
| 131 | Adaptation and Feasibility of The Community-Based Anxiety Program Tailored for Autism (CAPTA): A Randomized Control PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anxiety is very common in autistic youth. Recently, an intervention has been created by the investigators to target these symptoms in autistic youth in a community setting. The purpose of this study is to determine the feasibility of implementing this treatment in community care centers. |
ERIC A STORCH; | 2024-02-16 |
| 132 | Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for The Treatment of Anxiety Comorbid With Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators will recruit up to 10 patients with Anxiety comorbid with Autism Spectrum Disorder (ASD) from the outpatient clinics at MUSC. This pilot trial will be an open-label investigation of the safety and feasibility of transcutaneous auricular vagus nerve stimulation (taVNS) as a nonpharmacological wearable intervention used to manage anxiety and other neuropsychiatric symptoms at home, with patients/caretakers self-administering treatments. Each subject will undergo an initial in-person screening and be consented prior to participating in the study. This will be followed by an in-person training session with the subject (and caretaker if applicable), … |
STEWART COX; | 2024-02-10 |
| 133 | A Randomized Controlled Trial To Explore The Efficacy of Stellate Ganglion Block in Children With Autistic Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore efficacy of stellate ganglion block Children with Autistic Disorder. The main question it aims to answer is: Can stellate ganglion block improve the Autistic Disorder in children? Children with Autistic Disorder will be divided into the control group and experimental group evenly. All the patients were provided with routine therapy, while the patients in the experimental group were given stellate ganglion block. The Childhood Autism Rating Scale of the two groups of patients before and after treatment are evaluated. |
ZENG CHANGHAO; | 2024-02-05 |
| 134 | Improving Psychological Wellbeing Through Stress Reduction Among Parents Having Children With Neurodevelopmental Disorders: A Multi-pronged Intervention in Bangladesh PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This project addresses the mental health challenges faced by parents caring for children with Neurodevelopmental Disorders (NDDs) in Bangladesh. These parents often experience high levels of stress, anxiety, and depression, impacting family dynamics and the child’s development. The project aims to design, implement, and assess an intervention to reduce parenting stress and enhance parental well-being. This intervention focuses on emotional intelligence and will be delivered through in-person training and a mobile app. The study will use a cluster randomized controlled trial methodology, … |
MD ATIQUL HAQUE; | 2024-02-04 |
| 135 | Patterns of Disease, Outcomes and Treatment Response in Children With Neurodevelopmental Disorders PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders. |
RICHARD FRYE; | 2024-02-01 |
| 136 | Efficacy Evaluation and Mechanism Study of Ketogenic Diet on Autism Spectrum Disorder in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, which is characterized by social interaction and communication defects, rigid repetitive behaviors, and often accompanied by speech development retardation. According to the report released by the Morbidity and Mortality Weekly Report (MMWR) of the Centers for Disease Control and Prevention (CDC), according to the statistical data analysis in 2020, one out of every 36 8-year-old children (2.76%) was confirmed to have autism spectrum disorder (ASD). This ratio is higher than that published in December 2021, … |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2024-02-01 |
| 137 | Investigating The Effects of Combined Mental and Physical Stress PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effects of combined mental and physical stress on biomarkers of stress in healthy college aged individuals. The mental stress performed is a virtual reality active shooter drill that lasts ~3 minutes, and the physical stressor is a Ruffier squat test accompanied with jump rope, in order to examine the effects of combined stress versus physical stress alone. The main question to answer is: – What is the impact of combined stress in comparison to a single stressor on markers of subjective and biological stress? |
MATT MCALLISTER; | 2024-01-20 |
| 138 | Home Ultra-longterm EEG Monitoring for Rare Epilepsies and Developmental and Epileptic Encephalopathies. An Open Label Nonpharmacological Interventional Prospective Study By Means of Minimally Invasive Wearable EEG Device PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: With this study the Investigator expects to develop a precise patient-centered model of care by means of home ultra-long-term EEG monitoring with a minimally invasive wearable EEG device (sqEEG). The following aims will be pursued: 1. to assess the sensitivity, reliability, and safety of sqEEG to record seizures over prolonged periods; 2. to verify sensitivity and reliability of automated seizure detection algorithms and to assess circadian and ultradian seizure/interictal epileptic discharges; distribution for the development of personalized seizure action plan; … |
STEFANO MELETTI; | 2024-01-17 |
| 139 | Assessing Heterogeneity of Treatment Response in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Greater than 80% of children with autism spectrum disorder (ASD) experience sensory differences that make it difficult for them to fully participate in meaningful everyday activities. In this research study, we will use MRI and behavioral methods to assess how sensory interventions might change sensory brain structures, allowing us to better predict which sensory interventions might work best for whom. |
UNIVERSITY OF FLORIDA | 2024-01-16 |
| 140 | Caregiver’s Burden and Their Relationship to Physical Activity, Exercise Self-Efficacy, Perceived Exercise Benefits and Barriers in Caregivers of Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to examine the relationship between caregiving burden and physical activity, exercise self-efficacy, and perceived exercise benefits and barriers in caregivers of Caregivers of children with autism spectrum disorder (CwASD).The study population consisted of primary caregivers of a CwASD for at least 1 year. Caregiving burden was assessed using the Zarit Caregiver Burden Scale, physical activity using the International Physical Activity Questionnaire-Short form (IPAQ-SF), exercise self-efficacy using the Exercise Self-Efficacy Scale, and perceived exercise benefit using the Exercise Benefits/Barriers Scale. The relationship between caregiver burden and other parameters was analysed. |
GÜLLÜ AYDIN YAĞCIOĞLU; | 2024-01-15 |
| 141 | Predicting Language and Literacy Growth in Children With ASD Using Statistical Learning PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to test a reciprocal relationship between statistical learning and the development of language and literacy in first-graders with autism and their non-autistic peers. The main questions it aims to answer are: 1. whether children’s statistical learning abilities can predict their long-term improvement of language and literacy skills in school; 2. how children’s brains automatically learn patterns from speech and prints; … |
ZHENGHAN QI; | 2024-01-13 |
| 142 | Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus: A Double-blind Randomised Placebo-controlled Trial: The OxyTUTION Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized, placebo-controlled, double-blind trial aims to investigate intranasal OXT as a novel therapeutical option in central diabetes insipidus (cDI) to improve psychological symptoms and socio-emotional functioning. Optionally, patients can present for additional assessments in sub-studies: * fMRI sub-study at day 14 (± 2 days) (one additional visit) * Social-stress sub-study at day 14 (± 2 days) (one additional visit) |
MIRJAM CHRIST-CRAIN; | 2024-01-08 |
| 143 | Oxytocin Modulates The Processing of The Advantageous- and Disadvantageous-inequity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and whether oxytocin has similar effects on them or not. |
SHUXIA YAO; | 2024-01-07 |
| 144 | Effects of Probiotic Consumption in Children with Autism Spectrum Disorder (ASD) in The Metropolitan District of Quito, Ecuador PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine the effects of Saccharomyces boulardii (Sb) consumption on Ecuadorian children with a diagnosis of autism spectrum disorder (ASD) and digestive symptoms. Saccharomyces boulardii is a probiotic, in other words, a beneficial microorganism. The main question it aims to answer is: Does Sb improve intestinal health, defenses against infections, nutrition and behavior of the participants. Researchers will compare children when they are taking and not taking Saccharomyces boulardii to know if there are changes in digestive symptoms, immune system function, … |
PAÚL CÁRDENAS; | 2024-01-06 |
| 145 | Oral Health Care Guidance to Enhance Parent Confidence and Ability to Improve Toothbrushing Performance for Autistic Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Parents of autistic children have reported a lack of understanding by oral health care staff around delivery of oral health preventive habits for their children. This study aims to investigate if oral healthcare training utilising the Mini Mouth Care Matters (MCM) programme designed for Special Education Settings (SES) enhances parent confidence in their ability to influence their child’s oral health, … |
JENNIFER PARRY; | 2024-01-03 |
| 146 | Treating Anxiety in Young Children with Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anxiety is prevalent in young children, under 7 years of age, with autism. Yet, few studies have examined anxiety interventions for this age range, and only one anxiety treatment study has included young children with cognitive and language delays. Anxiety treatment models utilizing cognitive-behavioral therapy (CBT), adapted for children with autism, are empirically supported in school-age autistic children. Further, preliminary evidence suggests CBT approaches may reduce intolerance of uncertainty (IU), … |
AMY KEEFER; | 2024-01-02 |
| 147 | Pembangunan Dan Keberkesanan Modul Intervensi Berasaskan Sensori Dalam Kalangan Kanak-kanak Dengan Autisme / The Development and Effectiveness of Sensory-based Intervention Modules in Children With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the effectiveness of Sensory-based intervention modules on children with Autism Spectrum Disorder (ASD). The main questions this study aims to answer is How do children with ASD respond to Sensory-based intervention (SBI) in terms of their sensory processing, social skills, and play? Thus, the objective of this study is to determine the significant differences in sensory processing, social skills, and play in children with ASD before and after receiving the Sensory-based intervention (SBI) module in the intervention and control groups. Participants in this study are children with ASD, … |
NATIONAL UNIVERSITY OF MALAYSIA | 2024-01-01 |
| 148 | Probiotic Intervention for Microbiome Modifications and Consequential Clinical Improvements in Children With Fragile X Syndrome: Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this clinical trial is to evaluate efficacy of probiotic mixture which contains Lactobacillus casei, Lactobacillus salivarius and Bifidobacterium breve, in children with Fragile X aged 3-18 years. Specifically, links between microbiome modifications by probiotic mixture and behavioral manifestations and brain processing (eye tracker, EEG analysis) will be assessed. Exploratory objects of this trial are analyses of microbiome composition and assessment of its alterations and modifications (by probiotic mixture) that may lead to clinical improvement and prediction which patients with FXS may be likely to benefit from probiotics treatment. This is open label trial without masking, … |
DRAGANA PROTIC; | 2024-01-01 |
| 149 | Testing The Potential of High-dose Vitamin B6 Supplements for Sensory Reactivity in Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to explore the effect of Vitamin B6 supplementation on anxiety sensory hyperreactivity in autistic adults. Researchers will compare a placebo group to high-dose Vitamin-B6 to see if vitamin B6 reduce anxiety and sensory reactivity differences in autism. |
DAVID FIELD; | 2024-01-01 |
| 150 | De Novo Cerebral Microembolization Associated With Patent Foramen Ovale Closure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate (1) the de novo cerebral microembolization in patients who undergo transcatheter closure of PFO or ASD, and (2) evaluate the relationship between de novo cerebral microembolization and in situ thrombus within PFO. |
CHAOWU YAN; | 2024-01-01 |
| 151 | Factors Associated With Successful Completion of MRI in Children Undergoing A Vigil Sedation With Dexmedetomidin: An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective cohort study aiming to determine whether the use of Dexmedetomidine (DEX) to sedate children prior to MRI scanning is more or less effective in children with autism spectrum disorders or other neurodevelopmental disorders compared to other children. |
ANNE CHARLOTTE CULLIER; | 2024-01-01 |
| 152 | Psychiatric Comorbidities in Children With Generalized Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Epilepsy is defined as a chronic disorder that presents with recurrent episodes of unprovoked seizures. Epileptic seizures are caused by excessive excitation of cortical neurons. The condition has various etiologies and comorbidities. Classification; The Classification of Epilepsies includes several diagnostic levels (steps): 1. from seizure type to epilepsy type (generalized/focal/combined generalized and focal/unknown) 2. etiology (genetic/ structural/ infectious/ metabolic/ immune/unknown). A clinician can use any level of the classification |
ASMAA GAMAL HASHEM; | 2023-12-30 |
| 153 | Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Cognitive Functions and Behavior in Individuals with Autism Spectrum Disorder ( ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with core symptoms that include impairments in social communication and restricted and repetitive behaviors, interests, and activities. Social cognition is a broad term used to understand, perceive, and interpret information about others and ourselves in a social context. Impairments in social cognition are often highlighted as a potential mechanism underlying social disability in autism spectrum disorder. High-order cognitive functions, such as Executive function (EF) and social cognition, … |
HAYFA ALI ALGHABBAN; | 2023-12-21 |
| 154 | Co-Developing and Piloting Culturally-Responsive Informational Materials About Autism for Families of Young Children: Employing A Train-the-Trainer Implementation Model Within A Nonprofit Setting PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine how helpful and relevant the Family Care Project workbook is for families from culturally and linguistically diverse backgrounds who have a young child at autism likelihood. The main questions this trial aims to answer are: – Is the Family Care Project workbook useful for families? – Is the Family Care Project workbook easy to use? – Can the Family Care Project be implemented by non-profit workers who do not have health backgrounds? Participants will complete surveys that elicit their feedback on their use of the workbook. |
HANNAH BENAVIDEZ; | 2023-12-15 |
| 155 | Effects of Fundamental Motor Skills Program on Motor and Cognitive Abilities in School Going Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: School age child development is a range from 6 to 12 years of age. During this time period observable differences in height, weight, and build of children may be prominent. The language skills of children continue to grow and many behavior changes occur as they try to find their place among their peers. School-age children gain between four and seven pounds each year., Increases in height will vary, and a three-to-six height difference in age groups is typical. Growth spurts are common in school-age children, … |
MUHAMMAD ASIF JAVED; | 2023-12-05 |
| 156 | Evaluation of The Videodrama Therapeutic Device for Children with Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is a neurodevelopmental disorder (Valerie, Sperenza, 2009) that begins early in development, characterized by persistent deficits in communication and social interactions across various contexts and restricted, repetitive patterns of behavior, interests, or activities. These symptoms significantly impact social, school/professional functioning, or other important areas and are not better explained by intellectual disability or global developmental delay (American Psychiatric Association, 2013). |
CENTRE HOSPITALIER INTERCOMMUNAL ROBERT BALLANGER | 2023-12-04 |
| 157 | The Involvement of Sleep Spindle Waves in The Auxiliary Diagnosis of Social Memory Disorders in Children With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Research background and project basis Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder characterized by social disorders and repetitive stereotypical behavior. Social memory impairment is a significant feature of ASD patients, and the specific pathogenesis of social memory impairment in ASD patients is currently unclear, and there are no objective indicators to measure social memory levels. Sleep spindle wave is a special brain wave in sleep that is closely related to memory consolidation. However, … |
FIRST AFFILIATED HOSPITAL XI’AN JIAOTONG UNIVERSITY | 2023-12-04 |
| 158 | Russian Registry of Endovascular Closure of Patent Foramen Ovale PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will include all patients over 18 years of age who underwent endovascular closure of patent foramen ovale in medical centers in the Russian Federation, who gave written informed consent to the closure and provided personal data as part of inpatient medical care. The project participants will be 29 medical centers in the Russian Federation, where endovascular closure of patent foramen ovale is performed. |
ANDREY TERESHCHENKO; | 2023-12-01 |
| 159 | Adaptive Trial of Parent Empowerment and Coaching in Early Intervention: PEACE for ImPACT Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators will test the impact of the PEACE implementation toolkit and determine the level of implementation support needed to improve early intervention providers use of caregiver coaching with families of young children with autism who receive early intervention services. The study will also assess caregiver and child outcomes for families receiving caregiver coaching and the cost effectiveness of the PEACE implementation toolkit. The investigators will enroll 200 early intervention providers, and 400 parent-child dyads. |
MELANIE PELLECCHIA; | 2023-12-01 |
| 160 | A Multi-center, Single-arm, Real-world Registry Assessing The Clinical Use of The Lifetech CeraFlex™ ASD Closure System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this post-market registry is to assess the clinical use of the Lifetech CeraFlex™ Closure System in a real-world and on-label fashion. |
LIFETECH SCIENTIFIC SHENZHEN | 2023-12-01 |
| 161 | Effectiveness and Mechanism of Online Peer Companion Intervention on Children With Autism Spectrum Disorders: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional study was to examine the effectiveness and mechanism of online peer companion intervention (OPCI) on the social abilities and mental health of ASD children. The main questions it aims to answer are: 1. Whether OPCI is effective on the social abilities and mental health of ASD children; 2. What impact does OPCI have on the social abilities and mental health of ordinary children; 3. What impact does OPCI have on the mental health of both children’s parents; 4. What are the mechanisms of OPCI on ASD children. |
PEKING UNIVERSITY | 2023-12-01 |
| 162 | Effects of Cuevas Medek Exercises on Balance and Posture Control in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorders (ASDs) describe a group of neurodevelopmental conditions in which the individuals face challenges with social engagement. This childhood disorder is characterized by core impairments in social/communication and repetitive behaviors. Autism spectrum disorder (ASD) is a lifelong disorder that occurs in approximately 1 in 68 children aged 8 years. It is primarily characterized by limited social interaction and communication, restricted interest, … |
INTSAM ASLAM; | 2023-12-01 |
| 163 | A Pilot Study of Buspirone for The Treatment of Anxiety in Youth With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this exploratory 8-week pilot study is to evaluate the safety and efficacy of buspirone for the treatment of anxiety in youth (ages 6-17 years) with autism spectrum disorders. The study results will be used to generate hypotheses for a larger randomized-controlled trial with explicit hypotheses and sufficient statistical power. |
TOLGA A CERANOGLU; | 2023-12-01 |
| 164 | Comparative Study of Static Balance Abilities in Children With Autism and Neurotypical Peers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Virtual Reality Rehabilitation System (VRRS) is an innovative and sophisticated technology, aimed to generate immersive and interactive settings intended for therapeutic and evaluative objectives. Through the utilization of virtual reality technology, it constructs diverse scenarios, tasks, and activities in a controlled digital environment, fostering engagement. Primarily crafted for rehabilitation purposes, the VRRS features adaptable programs addressing various therapeutic requirements, encompassing motor skill enhancement, cognitive challenges, and assessments related to balance.Understanding the nuanced motor abilities in children, particularly those with neurodevelopmental conditions like autism, … |
FLAVIA MARINO; | 2023-12-01 |
| 165 | To Establish Developmental Regression-related Disease Cohort and Animal Model and Achievement Transformation Innovation Team PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The incidence rate of developmental regression is gradually increasing. In the early stages of children’s development, both ASD and DD patients can experience developmental regression, which in turn aggravates cognitive function impairment and seriously affects the effectiveness of intervention and treatment. However, the mechanism is unclear, and early screening and diagnosis are difficult. At present, the etiological mechanism of regressive autism and retardation patients at home and abroad is still unclear.This study will advance knowledge about the biological neurocognitive processes, … |
CHEN LI; | 2023-11-30 |
| 166 | A Blinded, Cross-Over Study to Evaluate The Safety and Efficacy of ARD-501 in Patients With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a blinded, placebo controlled, cross-over trial evaluating the safety of two dose-levels of in subjects with ASD. |
ANN CHILDRESS; | 2023-11-30 |
| 167 | Analysis on Graphic Tablet of Motor and Cognitive Components of Written Production in Adults With and Without Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective is to assess the psycholinguistic and graphomotor characteristics of written production in patients with ASD. The secondary objectives are: – Identifying links between specific deficits of ASD and difficulties in written production. – Identifying links between the severity of ASD and difficulties in written production. The primary evaluation criterion is the quantity of written production, namely the number of words produced in 5 minutes on a text copying task (BHK) and in 15 minutes on each of the two written production tasks (descriptive and persuasive). The secondary evaluation criteria are: – … |
EVAN LAUNAY; | 2023-11-29 |
| 168 | Evaluation of The Effect of Food Selectivity Intervention in Children With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Food selectivity is a common challenge among children with Autism Spectrum Disorder (ASD), with significant impacts on their nutrition and well-being. The main purpose of this study is to promote children’s active participation in mealtime routines and encourage experimentation with new foods through an approach that emphasizes joy and serenity during mealtimes. The study will involve children with ASD between the ages of 4 and 10 years, of both sexes. Food selectivity will be assessed through interviews with parents and the use of specially created cards. The protocol will include 45-minute sessions, twice a week, … |
FLAVIA MARINO; | 2023-11-23 |
| 169 | Peripheral Blood VA/TREM2 Levels and Their Correlation Analysis With The Development and Autistic Symptoms in Children With ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social impairment, repetitive behaviors, and narrow interests. With advancements in diagnostic techniques, the prevalence of ASD has been increasing annually. However, due to its complex and diverse etiology, there is no definitive consensus on the pathogenic mechanism of ASD. Numerous studies indicate that genetics, environment, and other factors play crucial roles in the onset of ASD. Vitamin A (VA) exerts its effects in the body through its active metabolite, retinoic acid (RA), … |
HUA WEI; | 2023-11-20 |
| 170 | The Effect of Posture, Hand Functions and Sensory Processing Skills on Nutrition in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine the effects of posture, hand functions and sensory processing skills on nutrition in children with autism spectrum disorder. The study aims to include 40 children diagnosed with Autism Spectrum Disorder (ASD), directed from the Department of Child and Adolescent Psychiatry at Istanbul University, along with their parents/caregivers, and 40 healthy children along with their parents/caregivers. |
ELIF DURGUT; | 2023-11-20 |
| 171 | Improving Theory of Mind in Children With Autism Spectrum Disorder Through Visual Perspective Taking Training: Behavioral and Functional Near-Infrared Spectroscopy Research PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to employ a longitudinal tracking research to investigate the effects of a visual perspective taking intervention on the development of theory of mind in children with autism. Additionally, the investigators seek to examine modifications in the neural mechanisms linked to facial emotion recognition in children both before and after intervention by using the functional Near-Infrared Spectroscopy (fNIRS) to record the relative changes in blood oxygen levels in the cerebral cortex with the oddball Face-Periodic Visual Stimulation (FPVS) paradigm. |
MI TIAN; | 2023-11-15 |
| 172 | Communication Training Around Sexual Health Topics for Parents of Youth With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effectiveness of using a Microskills video training library for training parents of adolescents with ASD in talking with their teens about relationships and sexual health topics. The main questions it aims to answer are: – Does using SkillTalk increase parents’ skills in communicating with their teens about relationships and sexual health? – Does using SkillTalk increase the frequency of conversations about relationships and sexual health? – Does using SkillTalk increase parents’ confidence in their ability to communicate with their teens about relationships and sexual health? – … |
ASHLEY PHILLIBER; | 2023-11-15 |
| 173 | A Randomised Controlled Trial on The Effectiveness of Improvisational Music Therapy for Autistic Children Aged 7 – 11 [Autism-CHIME Trial] PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effectiveness of individual sessions of improvisational music therapy for autistic children aged 7 – 11. Researchers will compare the impact of adding improvisational music therapy to usual care alone for autistic children over a 12-week period. Participants will be randomly assigned to one of the following two conditions: the Improvisational Music Therapy (intervention) Group or the support as usual (control) Group. The aim is to achieve seven overarching objectives: 1. To determine whether 12 weeks of individual sessions of improvisational music therapy in addition to support as usual is superior to support as usual alone in improving social communication in autistic children. 2. To examine whether 12 weeks of individual sessions of improvisational music therapy in addition to support as usual is superior to support as usual alone in improving communication skills in autistic children. 3. To examine whether 12 weeks of individual sessions of improvisational music therapy in addition to support as usual is superior to support as usual alone in reducing psychosocial problems in autistic children. 4. To examine whether 12 weeks of individual sessions of improvisational music therapy in addition to support as usual is superior to support as usual alone in improving wellbeing of autistic children. 5. To examine whether 12 weeks of individual sessions of improvisational music therapy in addition to support as usual is superior to support as usual alone in improving adaptive functioning in autistic children. 6. To examine whether 12 weeks of individual sessions of improvisational music therapy in addition to support as usual is superior to support as usual alone in improving anxiety in autistic children. 7. To examine whether the therapeutic relationship predicts the development of social, communication and language skills among autistic children. |
SIMON BARON-COHEN; | 2023-11-13 |
| 174 | Cortical Mechanisms of Speech in Noise Perception in Autism and Fragile X Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain’s response to background noise affect a person’s ability to understand speech? 2) Can visual cues improve hearing in background noise? Participants will complete the following: * hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism. |
ELIZABETH SMITH; | 2023-11-10 |
| 175 | Effects of Virtual Discrete Trial Training on Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is a neurodevelopmental disorder categorized by deficits in social communication and the occurrence of restricted interests and repetitive behaviors. The cautionary needs of children with ASD are significant, it affects parents and siblings as well and requires substantial social support. If adequate intervention is not provided to children with ASD on time, … |
SHAHZADI ARSHAD; | 2023-11-02 |
| 176 | Contribution of Central Auditory Processing Disorder (CAPD) to Sleep Disturbances in Autism Spectrum Disorder (ASD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study aims to understand poor sleep as a possible cause to CAPD in children and adolescents with ASD (ASD+) compared to ASD youth without CAPD (ASD-), using both caregiver-report and objective clinician administered measures. Additionally, the study will aim to understand the complex relationship between CAPD, sleep, and other associated phenotypic features of ASD such as executive and psychiatric functioning. |
AARTI NAIR; | 2023-11-01 |
| 177 | Effectiveness of Parent Led Implementation of A Virtual Reality Social Skills Training Program for Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional trial is to establish training protocols to show feasibility of training parents and caregivers to administer the VR protocol. The primary objective is to evaluate the effects of treatment with Floreo Building Social Connections (BSC) on the AIM, … |
KRESTIN RADONOVICH; | 2023-11-01 |
| 178 | Understanding The Neural Mechanism Behind Sensory Processing Anomalies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess sensory processing anomalies in neurotypical children, children with autism spectrum disorder, and attention-deficit hyperactivity disorder, particularly within the vibrotactile and auditory sensory modalities. |
DANIEL SKAK MAZHARI-JENSEN; | 2023-11-01 |
| 179 | The Effects of A Virtual Reality Game on Anxiety During Dental Procedures in Children (VR-TOOTH): A Randomized, Controlled Trial Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized clinical trial is to verify the efficacy of VR immersion over a muted cartoon on a wall-mounted TV to decrease dental fear and anxiety of children undergoing dental procedures. The study also aims to gain insight on the satisfaction of parents and healthcare providers on the use of VR during dental appointments. Main research question: Does VR immersion compare to a cartoon on a wall-mounted TV is more efficacious to decrease dental fear and anxiety of children requiring dental procedures? Participants will be playing through a VR immersive game wearing a eye-tracking VR headset that requires no movement of the head to play, facilitating the dental procedure. The investigators will take measures of the stress levels of participants and their parents using a validated stress scale and also by taking salivary samples to verify the levels of a stress biomarker (alpha-amylase). |
SYLVIE LE MAY; | 2023-11-01 |
| 180 | The Effect of Daily Executive Function Training in School-aged Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many studies support that children with autism spectrum disorder (ASD) show executive dysfunction. The applicant’s NSC project report also indicated that in all areas in the behavior rating inventory of executive function, the second edition (BRIEF-2), including inhibit, self-monitor, shift, emotional control, initiate, working memory, plan/organize, task-monitor, and organization of materials, children in the typically developmental group showed better performance than children in the ASD group. The results also indicated that compared to the diagnosis of ASD, an executive function could be a better predictor of daily life adaptation. Similarly, … |
MENG-TING CHEN; | 2023-10-31 |
| 181 | Description of The Impact of The Modelo Sentido’s® on The Adaptive Behaviors of Children Between 3 and 7 Years Old, on The Autism Spectrum and Other Associated Neurodevelopmental Challenges PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Knowing the impact of the Modelo Sentido´s® (MS) on the gain of adaptive behaviors in children on the autism spectrum (AS) and other associated neurodevelopmental challenges (ANDC), is essential to improve the quality of life of children, families and professionals who live with neurodevelopmental challenges; inform parents about the efficacy and effectiveness of the interventions offered; provide scientific knowledge required by government agencies, public and private policy makers to make informed decisions about which intervention they should support; contribute with a manualized intervention program contextually appropriate to the strengths and challenge within a low- and middle-income country, … |
BÁRBARA M TOMÁS; | 2023-10-30 |
| 182 | Assessing The Impact of Integrative Medicine on Anxiety and Wellbeing of Hospital Workers Exposed Directly or Indirectly to Terror, Trauma or War PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: During the Iron Swords war in Israel in 2023, the residents of the Gaza Strip and the surrounding area, along with the soldiers of the security service, … |
SAMUEL ATTIAS; | 2023-10-21 |
| 183 | Effect of Therapeutic Diet Along With Special Physiotherapy Program on Growth Motor Development and Cognitive Function in Autism Spectrum Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: : A clinical trial will be conducted to investigate the effect of free-gluten/ casein diet along with specific physiotherapy program on gross motor development and cognitive function in 3-12 years old children with ASD, And thus establish a streamlining of nutrition and physical activity for children with autism and ASD. |
MOHAMED MOUSTAFA MOHAMED AHMED; | 2023-10-17 |
| 184 | Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders: A Multi-center, Single Arm, Prospective, Open-label, Extendable Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, single arm, prospective, open-label, extendable study for the efficacy and safety of combo-stim deep brain stimulation for treatment-refractory mental disorders (obsessive-compulsive disorder, schizophrenia, bipolar with depression, anorexia nervosa, gambling disorder and adult autism). |
ZHEN WANG; | 2023-10-16 |
| 185 | Enhancing Theory of Mind Skills in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The project involves the participation of 40 children with Autism Spectrum Disorder of both sexes, aged between 6 and 10 years. The subjects will undergo a pre-intervention evaluation phase, which will consist of administering the Theory of Mind (ToM) test present in the NEuroPSYcology second edition (NEPSY) battery, part A. The same test will be administered again at the end of the intervention. Once the inclusion criteria have been met and following the randomization of the sample, divided into Experimental Group (EG n=20) and Control Group (CG n=20), … |
FLAVIA MARINO; | 2023-10-16 |
| 186 | ASDactive: Feasibility of An Integrated Theory-based Intervention to Promote Habitual Physical Activity Behaviours in Autistic Youth PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: ASDactive is a theory-based behaviour change intervention aimed at improving the physical activity behaviours of autistic youth. The feasibility of the intervention will be tested through interviews with participants and stakeholders. Proof of concept will be tested through preliminary measures of physical activity measured before and after the intervention. |
KATHRINE PARSONS; | 2023-10-01 |
| 187 | The Effect of Parent-Mediated Intervention Program on Children’s Autism Symptoms, Behavioral Problems and Parents’ Stress Level in Children With Autism Spectrum Disorder Exposed to Earthquake in Turkey in February 2023 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After devastating natural events such as earthquakes, individuals with special needs experience much more difficulties. There is a limited number of studies investigating the impact of disasters on individuals with autism. Studies show that resilience and recovery of pre-disaster functioning in young people with autism largely depends on their immediate inclusion in routine, … |
SABRI HERGÜNER; | 2023-10-01 |
| 188 | Personalized Brain Functional Sectors (pBFS) Guided Noninvasive Neuromodulation Treatment for Pre-school Children With Autism Spectrum Disorder (ASD): A Single-center, Double-blinded, Sham-Controlled, Randomized Clinical Trial Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial aims to evaluate the efficacy and safeness of the pBFS-guided rTMS intervention for core symptom relief in pre-school children with autism spectrum disorder (ASD). |
CHANGPING LABORATORY | 2023-10-01 |
| 189 | Effects of Ayres Sensory Integration Therapy Versus Conservative Treatment in Autism Spectrum PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: This study named effects of ayres sensory integration therapy versus conservative treatment in autism spectrum is a randomized clinical trail study.There is no evidence-based … |
MUHAMMAD NAVEED BABUR; | 2023-10-01 |
| 190 | An Exploratory, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating The Effect and Safety of Pitolisant in Children and Adolescents With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Proof of concept, multicenter, randomized, double-blind, placebo-controlled, parallel-group, study to investigate the effect, safety, tolerability and pharmacokinetics of pitolisant in male children and adolescents with Autism Spectrum Disorders. |
OLIVIER BONNOT; | 2023-10-01 |
| 191 | The Effect of Animal-Assisted Therapy on Prosocial Behavior and Emotional Regulation in Autistic Children: Comparison Between A Live Canine and A Toy Canine Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigated the human-animal interaction (HAI) and bond (HAB) between a canine trained in therapy techniques or a canine plush toy and youth with autism spectrum disorder (ASD) during animal-assisted therapy (AAT) sessions. The purpose of this study is to explore identified gaps in knowledge pertaining to AAT in pediatric ASD care management by documenting human interaction between either a live canine or the plush toy canine during AAT sessions and evaluating prosocial behaviors observed during and after AAT sessions. This study addressed the following research questions: 1. How do children with autism ages 2 to 18 years interact with a live canine during AAT sessions? 2. How do children with autism ages 2 to 18 years interact with a toy plush dog during AAT sessions? 3. Is there a difference in HAI in the live canine group and the toy plush dog group? 4. Is there a difference in prosocial behavior observed during AAT sessions between the live canine group and the toy plush dog group? 5. Is there a difference in behavior after AAT sessions between the live canine group and the toy plush dog group? Participants were randomly assigned to either the live canine or toy plush dog group. Adaptive functioning and social responsiveness evaluations were obtained to compare baseline behavior between the two groups. Participants attended an AAT session once weekly for 6 to 8 weeks. Each group received the same therapy provided by the therapist; the only difference being the incorporation of a live canine during the therapy session. Caregivers completed a weekly assessment depicting participants’ positive and negative affect at the beginning of each session. Caregivers also completed a monthly assessment noting strengths and difficulties in social functioning and behavior at the start of the first, middle, and final session. AAT sessions were recorded and behavior occurring during the sessions was coded to note HAI and HAB that occurred during the sessions. |
MICHELE KILMER; | 2023-10-01 |
| 192 | Investigating The Clinical Utility of The Oxford Virtual Autism Assessment Tool (OVAAT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to evaluate a new Autism Spectrum Disorder (ASD) diagnostic tool (Oxford Virtual Autism Assessment Tool (OVAAT)) to see whether it can: – Be able to identify autistic traits – Be able to distinguish between autistic and non-autistic young people – Is the tool better, similar or worse than another evidence-based observational tool (ADOS-2) in identifying features of autism? |
OXFORD HEALTH NHS FOUNDATION TRUST | 2023-09-22 |
| 193 | Evaluating Efficacy of A Digital Game Based Therapeutic for Improving Socialization Outcomes in Autistic Children, A Randomized Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The following study aims to assess the efficacy of the game-based digital therapeutic, GuessWhat, in improving adaptive socialization skills in children with Autism Spectrum Disorder (ASD). GuessWhat is a mobile application (available for free for iOS and Android) which contains a suite of games: pro-social charades, emotion guessing, and quiz. Participant families will use their personal smartphones to download the app and play it with their child according to a predetermined regimen. |
DENNIS PAUL WALL; | 2023-09-21 |
| 194 | Washed Microbiota Transplantation (WMT) for Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. Intestinal microbial disturbance is common in children with ASD. A great deal of evidence shows that intestinal microbes can influence the brain to play its role through gut-brain-microbiota axis. We intend to explore the role of Washed Microbiota Transplantation in improving symptoms of children in autism spectrum disorder; To study the potential etiological mechanism of autism spectrum disorder. |
THE SECOND HOSPITAL OF NANJING MEDICAL UNIVERSITY | 2023-09-20 |
| 195 | Effect of Omega-3 Fatty Acid on Neurobehavioral Status of Children With Autism Spectrum Disorder: A Randomized, Double- Blind, Placebo Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is conducted to assess whether Omega-3 fatty acid improves neurobehavioral staus of children with Autism Spectrum Disorder and whether there is any correlation of this improvement with reference range of Omega-3 fatty acid. |
SHAWSUN TAMANNA CHOWDHURY; | 2023-09-19 |
| 196 | Broad Phenotype Children With Autism in Kent, Surrey, and Sussex: Developing A Self-Report Questionnaire Prioritising Individual Self-Care PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Referrals for autism assessment have greatly increased in the last few years. This means that waiting times are longer for families, and children and young people are struggling to get the support they need. This also means that the number of autistic children and young people there is assumed to be is not correct. A better understanding of the true number of autistic children and young people is needed so that better support for them can be provided. This research aims to understand what autism looks like in Kent, Surrey, … |
SOPHIE MCGREVEY; | 2023-09-18 |
| 197 | Comparative Study Between Ultrasound Guided Pericapsular Nerve Block Versus Iv Sedation Analgesia in Reduction of Shoulder Dislocation, Double Blinded Controlled Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: When someone experiences a shoulder dislocation, it can be extremely painful. Emergency physicians often choose to use conscious sedation to help reduce the pain. However, some patients may not be able to tolerate conscious sedation due to concerns about their ability to breathe properly or the risk of inhaling fluids. A recently developed technique called Ultrasound-guided Pericapsular Nerve Group (PENG) block is used to block the articular branches of the shoulder and the pericapsular spread around the glenohumeral joint. The PENG block is commonly used in hip surgery and is effective in providing motor-sparing analgesic results. |
FATMA AHMED ABDEL FATAH; | 2023-09-15 |
| 198 | Caregiver Skills Training: Comparing The Effectiveness of Training Clinicians Via Telehealth and In-Person Training PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Caregiver Skills Training (CST) is an evidence-based intervention for parents of young children with developmental disabilities that was developed through a collaboration between Autism Speaks and the World Health Organization. The intervention is typically offered by Facilitators who are trained and supervised by CST Master Trainers. This study seeks to use a remote training model to compare two training and supervision processes. One group, comprised of facilitators from rural settings, will be trained and supervised by two master trainers from the University of Pittsburgh using a remote training model. A second group, … |
BENJAMIN L HANDEN; | 2023-09-15 |
| 199 | Evaluation of Theta Burst Transcranial Magnetic Stimulation As An Adjunct to Standard Therapy in Improving Core Function Deficits in Children 5-15 Year Age With Autism Spectrum Disorder – A Randomized, Double Blind, Sham Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate Theta Burst Transcranial Magnetic Stimulation as an adjunct to standard therapy in improving core function deficits in children 5-15 year age with Autism Spectrum disorder. The main question it aims to answer is whether Theta burst Transcranial Magnetic Stimulation would improve core function deficit in children age 5 – 15 years with Autism Spectrum Disorder as an adjunct to standard therapy. Participants will receive patterned transcranial magnetic stimulation- … |
SHEFFALI GULATI; | 2023-09-15 |
| 200 | Effectiveness of A YouTube-delivered Nutrition Education Intervention Among Parents of Children With Obesity and Autism: The Intervention Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Parents as primary caregivers play an important role in shaping children’s mealtime and eating behaviors; and in preventing weight gain. Conventionally, in-person, parent-implemented treatments have worked well for children with autism, however, post-COVID-19 pandemic there is a need for virtual, evidence-based training for parents to improve nutrition in children with autism and weight issues. This study aims to: a) increase self-efficacy among parents of children with autism and overweight or obesity to feed their children a healthy diet, b) improve parental nutrition knowledge and skills on how to feed their child with autism and overweight or obesity a healthier diet, … |
MITESHRI D PRAJAPATI; | 2023-09-07 |
| 201 | The Effect of Cognitive Orientation Approach on Daily Occupational Performance on Executive Functions and Occupational Participation in Children With Autism Spectrum Disorder: Randomized Controlled Study With 1 Month Follow-up PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is by using the Cognitive Orientation Approach on Daily Occupational Performance, which is also supported by the literature and applied by occupational therapists, in children diagnosed with Autism Spectrum Disorder, it is aimed to determine how children’s executive function scores and occupational participation change. The main questions it aims to answer are: – Does the Cognitive Orientation Approach on Daily Occupational Performance have an effect on executive functions? – Does the Cognitive Orientation Approach on Daily Occupational Performance have an effect on occupational performance? Participants will: – … |
ZEYNEP ÇORAKCI YAZICIOĞLU; | 2023-09-04 |
| 202 | Evaluation of Some Inflammatory Markers in Autism Spectrum Disorders PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate some Inflammatory markers [IL-6, IL-8, TNF_alpha] in children with autism spectrum disorder |
GHADA MOHAMED ALI; | 2023-09-01 |
| 203 | A Pilot Randomized Controlled Trial of Stepped Vs Stratified Care for Pediatric Anxiety Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to evaluate the feasibility, acceptability, and safety of two care pathways (including internet-delivered cognitive behavioral therapy [CBT] and/or in-person CBT) for children and adolescents with anxiety disorders. |
EVA SERLACHIUS; | 2023-09-01 |
| 204 | ACT (Acceptance Commitment Therapy) Combined with Yoga for Parental Burnout in Parents with Autistic Children: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: OBJECTIVE: To explore the intervention effect of ACT combined with a yoga intervention program on parenting burnout in parents with ASD. METHODS: This study used a combination of qualitative research and quantitative analysis to examine the intervention effects of an ACT-centered intervention program on parenting burnout in parents of children with ASD, and to clarify the evaluations and perceptions of parents with ASD about the research program through qualitative research. RESULTS AND CONCLUSION: To clarify the intervention effect of ACT combined with yoga intervention program on parenting burnout of ASD parents. |
JIAYI CHEN; | 2023-09-01 |
| 205 | Digital Interventions for Social IsOLation In YouThs And TheIR FamiliEs PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to implement multimodal digital interventions for adolescents and young adults with social isolation (SI) and their family members. Furthermore, the neurobiological basis of SI will be explored by analyzing blood neuroinflammation biomarkers in socially isolated participants. The main questions that this project aims to answer are: – What is the general feasibility and applicability of the proposed digital interventions? – What is the effect of the proposed digital interventions on the SI-related clinical symptoms and the cognitive and global functioning of participants with SI? Participants will be asked to undergo: – … |
MIRELLA RUGGERI; | 2023-09-01 |
| 206 | Vitamen D in Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the present study, we aim to evaluate the serum level of 25 hydrxy vitamin D in autistic children . |
AHMED ABDELMONEIM AHMED; | 2023-09-01 |
| 207 | Evaluating The Effect of Use of Technologies to Increase The Cognitive Abilities in Children With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Applied Behavior Analysis (ABA) is a therapeutic approach for autism that is based on the principles of behavioral theory, learning, and positive reinforcement. Current research shows that early and intensive ABA intervention is effective in reducing dysfunctional behaviors and promoting learning and enactment of socially appropriate behaviors. In this context, new approaches that attempt to integrate advanced technologies can play a key role. This experimental protocol aims to test whether the use of advanced technologies, such as tablets, … |
FLAVIA MARINO; | 2023-09-01 |
| 208 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase III Clinical Trial to Evaluate The Efficacy and Safety of AST-001 Followed By An Open-Label Extension Treatment Period in Children With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Study purpose: To demonstrate the superiority of AST-001 compared to placebo in improving core symptoms of autism spectrum disorder (ASD) in children with ASD. 2. Background: ASD is a neurodevelopmental disorder characterized by deficits in social communication and social interaction as well as restricted, repetitive patterns of behavior, interests, or activities. There are no approved medicines to treat the core symptom of ASD. Although these drugs and other psychotropic medications are associated with side effects, … |
YOO-SOOK JOUNG; | 2023-08-29 |
| 209 | A Comparison of Two School Based Interventions to Manage Anxiety in Autistic Students PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare two school based interventions to manage anxiety in autistic students. The main question\[s\] it aims to answer are: 1) Compare the effectiveness of Facing Your Fears-School Based Program (FYF-SB) with Zones of Regulation (ZOR) on anxiety reduction and emotion regulation; and 2) examine the feasibility and satisfaction of FYF-SB and ZOR, according to students, caregivers and school providers. Autistic students with anxiety between 8-14 years will be randomized to either FYF-SB and ZOR. They will participate in one of the programs for 12 weeks and pre, … |
JUDY REAVEN; | 2023-08-25 |
| 210 | Effects of Exergaming on Gait and Fall Risk in Children With Autism Spectrum Disorder (ASD): A Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: Autism Spectrum Disorder (ASD) is characterized as a neurodevelopmental disorder, with motor symptoms that may predispose to falls and gait changes. Exercises through virtual reality (exergaming) showed good results in children with ASD, but no studies were found that evaluated the effects of exergaming on gait and the risk of falls. Objective: To evaluate the effects of exergaming on motor performance during gait and the risk of falls in children with ASD. Method: Pilot study of a clinical trial. There will be 22 participants, diagnosed with ASD, level I or II; age: 5 to 9 years old; … |
KAREN VALADARES TRIPPO; | 2023-08-25 |
| 211 | A Prospective, Multi-Center Study of Dynamic Quantification of Social-Visual Engagement (DQSVE) in Autism Spectrum Disorder (ASD): Diagnosis and Assessment For Children PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to learn about the utility and performance of the EarliPoint System (™): Evaluation for Autism Spectrum Disorder to diagnose and assess autism spectrum disorder (ASD) in children ages 31-96 months (2.5 – … |
EARLITEC DIAGNOSTICS | 2023-08-23 |
| 212 | Telehealth Parent-only Treatment for Youth With Autism Spectrum Disorder and Overweight/Obesity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this proposed study is to collect initial efficacy data on a telehealth parent-based behavioral program for children with autism and overweight or obesity (PBT-A), compared with health education (HE). |
KERRI BOUTELLE; | 2023-08-18 |
| 213 | Taurine Supplementation Improves Core Symptoms in Children With Autism Spectrum Disorders: An Exploratory Randomized, Double-blinded, Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the treatment of autism spectrum disorders (ASD), medication is only an adjunct, and the main treatment modalities are education and behavioral therapy. People with autism incur huge medical and educational costs, which puts a great financial burden on families.Taurine is one of the abundant amino acids in tissues and organs, and plays a variety of physiological and pharmacological functions in nervous, cardiovascular, renal, endocrine and immune systems. A large number of studies have shown that taurine can improve cognitive function impairment under various physiological or pathological conditions through a variety of mechanisms, … |
HAO ZHOU; | 2023-08-18 |
| 214 | Early Life Anemia and Children’s Risk of Neurodevelopmental Disorders: National and Regional Register-based Studies PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall project aim is to study children’s neurodevelopmental outcomes (including diagnoses of autism, ADHD, and intellectual disability) following exposure to maternal anemia during pregnancy or anemia during the first year of life using national and regional Swedish health-data registers, and to assess children’s neurodevelopmental outcomes over the range of maternal hemoglobin levels during pregnancy. |
RENEE GARDNER; | 2023-08-15 |
| 215 | Integrated Platform for Measuring and Reducing Symptoms of Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will consist of a randomized, double-blind, sham-controlled clinical trial at SUNY Upstate Medical University with 40 autistic children evaluating the effects of transcranial photobiomodulation (tPBM) on multiple clinically validated scales. |
STATE UNIVERSITY OF NEW YORK UPSTATE MEDICAL UNIVERSITY | 2023-08-15 |
| 216 | Randomized Placebo-controlled Crossover Trial of Diphenhydramine for Sleep in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the effect of diphenhydramine on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Diphenhydramine is an anti-histaminergic agent with strong hypnotic properties. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of diphenhydramine on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures. |
ANTONIO HARDAN; | 2023-08-09 |
| 217 | Acceptability, Feasibility, and Development of An AI Driven, Multi-sensor, Non-invasive Digital Mental Health Platform in Children With ADHD and Emotional Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study collecting data using a wearable to measure the biometric features in youth with Attention deficit hyperactivity disorder(ADHD) and Autism. |
MAXISHEALTH | 2023-08-09 |
| 218 | Randomized Placebo-Controlled Crossover Trial of Suvorexant for Sleep in Children with Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the effect of suvorexant on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Suvorexant is a selective, dual orexin receptor antagonist (DORA) used for the treatment of sleep onset difficulties and/or sleep maintenance. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of suvorexant on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures. |
ANTONIO HARDAN; | 2023-08-09 |
| 219 | Randomized Placebo-Controlled Crossover Trial of Zolpidem for Sleep in Children with Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the effect of zolpidem on sleep in children and adolescents with Autism Spectrum Disorder (ASD). Zolpidem is a nonbenzodiazepine GABAa receptor agonist drug that acts as a hypnotic. To accomplish this, the investigators will use a randomized double-blind placebo-controlled crossover 8-week study design to examine the effect of zolpidem on sleep physiology as assessed by polysomnography (PSG), actigraphy, circadian rhythm, and clinical measures. |
ANTONIO HARDAN; | 2023-08-09 |
| 220 | Pilot Testing of A Mobile Phone App-based Intervention for Supporting and Empowering Parents of Children With Autism Spectrum Disorder (ASD): A Mixed-method Study of Feasibility, Acceptability, and Preliminary Efficacy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to conduct a pilot randomised controlled trial (RCT) evaluating the feasibility, acceptability, and preliminary efficacy of a 6-week mobile app-based intervention in empowering and supporting Chinese parents of autism spectrum disorder (ASD) children through knowledge and skills transfer and mindfulness training. The investigators hypothesise that the app will be feasible and acceptable, and that there will be a greater reduction in parental stress and mood symptoms, and improvement of mindfulness attitude and parenting competence in parents with ASD children after the 6-week app-based intervention than the waitlist controls. |
WONG WING HO; | 2023-08-01 |
| 221 | Neuroregulatory Effect and Mechanism of Transcranial Direct Current Stimulation on Medial Prefrontal Cortex in Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this proposed study, a transcranial direct current stimulator is used to intervene in the medial prefrontal cortex of children with autism, and the efficacy of this intervention method is evaluated, as well as the internal mechanism of Autism Spectrum Disorders’ intervention is discussed. |
JIAN-JUN OU; | 2023-08-01 |
| 222 | Implementation of The Parents Taking Action With Caregivers of Young Autistic Children in Paraguay PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The principal aim of this study is to conduct a single group design pilot of a psychoeducational caregiver training (i.e., culturally adapted Parents Taking Action) with a group of family caregivers of young children with autism in Paraguay. The following research questions will be addressed: Research Question #1: What is the feasibility and acceptability of the intervention? Research Question #2: Do participants improve between pre and post-test on outcome measures? Parents will receive 10 weekly remote sessions on information about autism and strategies to support their child’s development. The weekly sessions will be held via telehealth by the researcher and 2 and 2 Paraguayan trained parents of autistic individuals. |
SANDY MAGANA; | 2023-08-01 |
| 223 | Determination of The Median Effective Dose of Propofol in Combination With Different Doses of Esketamine During Colonoscopy for Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the dose-response relationship of esketamine in combination with propofol for children with Autism Spectrum Disorder undering colonoscopy. |
THE SECOND HOSPITAL OF NANJING MEDICAL UNIVERSITY | 2023-07-30 |
| 224 | Developing A Culturally Adapted Intervention for Latino Youth Transitioning to Adulthood PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the acceptability, feasibility (e.g., satisfaction, completion rate, barriers to recruitment, treatment fidelity) of the culturally refined Launching! to Adulthood (¡Iniciando! la Adultez) program and to test for a preliminary signal of effect between baseline and post-treatment for the Launching! to Adulthood (¡Iniciando! la Adultez) program. |
ANTONIO PAGAN; | 2023-07-29 |
| 225 | A Phase IIa Multicenter, Open-label, 12-week Study to Investigate The Pharmacokinetics and Safety and to Provide Proof of Mechanism of Alogabat in Children and Adolescents Aged 5-17 Years With Angelman Syndrome (AS) With Deletion Genotype PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a two-part, Phase IIa, multicenter, 12-week, open-label study. Up to 56 participants with deletion AS aged 5-17 years (inclusive) will be enrolled in the study. |
HOFFMANN LA ROCHE | 2023-07-27 |
| 226 | Use of Augmented Reality for Restricted and Repetitive Behavior and Executive Function of Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to determine the effects of usage of augmented reality for Restricted and repetitive behavior and executive function of children with autism spectrum disorder |
SUMAN SHERAZ; | 2023-07-25 |
| 227 | Application of Esketamine in Anesthesia of Autism Children Undergoing Colonic Transendoscopic Enteral Tubing PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. Autistic children appear with significant frequency for medical services, lots of which requiring procedural sedation or anaesthesia. Autistic children have often been described as difficult to sedate or anesthetize due to a variety of ASD symptoms. It is a challenging task to provide safe and effective sedation during the procedure of colonic TET for FMT in autism children. The investigators intend to explore an optimum anesthetic regimen for autism children undergoing endoscopic procedures. |
THE SECOND HOSPITAL OF NANJING MEDICAL UNIVERSITY | 2023-07-20 |
| 228 | Interactive Mirroring Games WIth SOcial Robot (IOGIOCO) and Robotic System Adapted Into A Clinical Scale (RISCALE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The importance of early intervention in Autism Spectrum Disorders (ASD) has been widely demonstrated, and developmental trajectories in ASD highlight the importance of nonverbal communication, such as intransitive gesture production, as a possible positive prognostic factor for language development. The use of technological tools in the therapy of individuals with ASD has also become increasingly important due to their increased engagement and responsiveness to technological objects, such as robots. Materials and methods: We developed a training protocol using the humanoid robot NAO, called IOGIOCO (Interactive mirroring Games wIth sOCial rObot), … |
FONDAZIONE DON CARLO GNOCCHI ONLUS | 2023-07-14 |
| 229 | More and Less Social Comprehension: Child and Text Factors for Autistic Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this early Phase 1 clinical trial is to assess if the social content of a story impacts autistic children’s listening comprehension of stories. The main questions this study aims to answer are: * Does removing social content from a story improve listening comprehension in autistic children? * Does listening comprehension of more social versus less social stories differentially predict performance on a standardized reading comprehension measure? Participants will listen to more social and less social stories while viewing accompanying pictures and answer comprehension questions about the stories and complete a standardized assessment of reading comprehension. In addition, … |
MEGHAN M. DAVIDSON; | 2023-07-10 |
| 230 | The Effect of Sleep Hygiene Training Implemented With The Combined Package Program on Sleep Deprivation and Sleep Habits in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Good and quality sleep, which has an important place in the lives of all living things; important for the health and well-being of children. Proper sleep habits are needed for quality and adequate sleep. According to the National Sleep Foundation, these habits include practices such as regular bedtimes, sleep routines, screen restrictions before bed. With the age of starting school in children; Due to the roles brought by school, lessons and social obligations, problems such as delay in bedtime and shorter sleep time are seen. Shortening of sleep time causes sleep deprivation. sleep deprivation; … |
SEMRA KOSE; | 2023-07-09 |
| 231 | An Online Evaluation of Work Chat: A Virtual Workday Among Employed Autistic Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is aiming to see if it is feasible for the intervention Work Chat to be delivered in a completely online setting to adults with autism spectrum disorder. |
MATTHEW SMITH; | 2023-07-07 |
| 232 | Musical Rhythm Sensitivity to Scaffold Social Engagement in Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of this study is to examine rhythm sensitivity as a predictor of response to naturalistic developmental behavioral intervention (NDBIs) in autistic toddlers. Toddlers receive either Reciprocal Imitation Training (RIT), an evidence-based NDBI that supports children’s imitation and social communication skills, or a music-enhanced version of RIT. Throughout their participation in the intervention, toddlers will complete study procedures of viewing naturalistic videos of infant-directed singing and other social scenes while eye gaze data is collected. |
MIRIAM LENSE; | 2023-07-03 |
| 233 | EFFECT OF RISPERIDONE Vs ARIPIPRAZOLE ON OXIDATIVE STRESS IN PATIENTS WITH AUTISM SPECTRUM DISORDER: A RANDOMIZED CONTROLLED TRIAL PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this Randomized Controlled Trial is to to compare the effect of Risperidone vs Aripiprazole in terms of change in serum Glutathione level in patients with Autism Spectrum Disorder over a period of 6 weeks. The main questions it aims to answer are: 1. (Primary Outcome) Change in serum Glutathione levels following 6 weeks of intervention in both the arms 2. (Secondary Outcomes) Change in serum superoxide dismutase (SOD) levels following 6 weeks of intervention. Change in ISAA score following 6 weeks of intervention. Change in ABC-C score following 6 weeks of intervention. • Adverse events reported in both groups Details of intervention- One arm of the study population to get Risperidone 1mg/day for a total duration of 6 weeks and another arm to get Aripiprazole 2mg/day for a total duration of 6 weeks. Baseline assessment of Serum Glutathione, Serum SOD, ISAA scale, ABC-C scale will be done and same will be assesssed at 6 weeks follow up. |
DEBADATTA MOHAPATRA; | 2023-07-01 |
| 234 | Families FORWARD: Development of A Family-Based Transition Planning Program for Culturally-Diverse Youth on The Autism Spectrum PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to develop a community-based program to support family members of transition-aged youth on the autism spectrum to help them plan for the future. The main aims of the study are: 1. To develop the Families FORWARD program 2. To conduct proof-of-concept testing of the Families FORWARD program Participants will complete surveys before and after participating in the program and will participate in exit interviews at the end of the program. |
KRISTIN LONG; | 2023-07-01 |
| 235 | Effects of Augmented Reality Game-based Training on Social Communication of Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to determine the effects augmented reality game-based training on social communication of children with autism spectrum disorder. |
SUMAN SHERAZ; | 2023-07-01 |
| 236 | Randomized Controlled Trial of Intranasal Midazolam Vs Intranasal Dexmedetomidine Vs Intranasal Ketamine Evaluating Length of Stay After Medication Administration and Anxiolysis During Minimal Procedures in Pediatric Population in Pediatric Emergency Department PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to optimize patient and family experience and allow for successful and efficient procedure completion. This is the first study that will compare three intranasal medications (Intranasal Midazolam, Dexmedetomidine, … |
RYAN MCKEE; | 2023-07-01 |
| 237 | First CRUSH: Piloting The Preliminary Feasibility and Acceptability of The Competence in Romance and Understanding Sexual Health (CRUSH) Curriculum PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the feasibility and acceptability of a behavioral intervention in designed to provide sexual education and improve the behavioral skills of autistic adults for intimate relationships. The main questions it aims to answer are: – Acquire feasibility and acceptability data for delivery of the CRUSH curriculum in a group didactic setting plus 1-1 coaching. – Acquire feasibility and acceptability data regarding the assessment battery for future clinical trials. Participants will complete: – A screening call. – Provide documentation of a diagnosis of autism spectrum disorder. – … |
SUSAN FAJA; | 2023-07-01 |
| 238 | Adapting An Advocacy Services Intervention for Latinx Families of Transition-aged Youth With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: When youth with autism spectrum disorder (ASD) transition from school to adult services, they fall off a service cliff. To increase access to services, the investigators developed the ASSIST program, which teaches parents how to advocate for adult services on behalf of youth with ASD. In a pilot randomized controlled trial (RCT: R34 MH104428), treatment group (versus control) participants demonstrated significantly improved knowledge of adult services, advocacy, and empowerment. Sons/daughters of treatment group participants had increased access to services. For advocacy services interventions like ASSIST to be equitable, … |
MEGHAN BURKE; | 2023-06-28 |
| 239 | ABLLS-R and Portage Guide in The Development of Receptive Language Skills in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Language is the system someone uses to communicate with another person. This covers the origins and construction of words, their definitions, and the use of language in various contexts. In normally developing children, receptive language skills are typically much more advanced than expressive language skills. However, … |
ALEENA IRUM; | 2023-06-10 |
| 240 | An Open-label Extension Study to Investigate Safety and Tolerability of ML-004 in Adolescents and Adults with Autism Spectrum Disorders (ASD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ML-004-003 is a multi-center, open-label extension study that will enroll approximately 120 adolescent and adult subjects with ASD that have completed study ML-004-002. The primary objective of the study will be to evaluate the safety of ML-004 in subjects with ASD. |
MAPLIGHT THERAPEUTICS | 2023-06-01 |
| 241 | Investigation of The Effect of Snoezelen-Based Occupational Therapy Intervention on Sleep and Behavioral Problems in 18-36 Months Children at Risk of Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: Sleep and behavioral problems are common in infants at risk of autism. This study aims to examine the effect of Snoezelen-Based Occupational Therapy intervention on sleep and behavioral problems in infants at risk of autism. Design: Twenty-four infants (15 boys, 9 girls) at risk for autism were randomized to the intervention group (n = 12; 28.33 ± 6.52 months) and the control group (n = 9; 30.11 ± 5.20 years). The intervention group received Snoezelen-Based Occupational Therapy intervention in addition to the conventional 8-week sensory integration intervention, … |
YUSUF ISLAM DEGERLI; | 2023-06-01 |
| 242 | The Effect of Physiotherapy and Nutrition Services Provided By Telerehabilitation Method on The Physical, Nutrition and Psychological Conditions of Children With Autism and Their Families PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study, which investigators named the Effect of Physiotherapy and Nutrition Services Provided with Telerehabilitation Methods on the Physical, Nutrition and Psychological Conditions of Children with Autism and their Families, was aimed to evaluate the effects of physiotherapy and nutrition education to be given to families. Children with autism spectrum disorder There will be questionnaires that investigators will ask participants to answer about your personal information and some questions about your life. Via a smart phone video conference to caring parents of children with autism; In this project, … |
SAGLIK BILIMLERI UNIVERSITESI | 2023-06-01 |
| 243 | The Effect of Mındfulness-Based Stress Reductıon Program Applıed to Parents Wıth A Chıld Wıth Autısm on The Level Of Depressıon, Anxıety, Stress and Hopelessness: Randomızed Controlled Trıal PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research was planned to examine the effect of mindfulness-based stress reduction program applied to parents with autistic children on the level of depression, anxiety, stress and hopelessness. |
SELVERHAN YURTTUTAN; | 2023-06-01 |
| 244 | Effects of The Virtual Reality Dream Game on Anxiety During Dental Procedures in Children (VR-TOOTH): A Pilot Randomized, Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction. Dental fear and anxiety (DFA) is a condition that affects approximately a quarter of children and adolescents. Lack of patient cooperation due to DFA can create an environment of stress, … |
SYLVIE LE MAY; | 2023-06-01 |
| 245 | Motor Skills in Children With Attention Deficit and Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Physiotherapists have positive effects on motor skills, executive functions and symptoms of children with attention deficit and hyperactivity disorder. However, progression takes time due to the symptoms of the disease. Physiotherapists need strategies to manage the symptoms of ADHD. Music can be used as a strategy because music is known to reduce the symptoms of children in this group. There is no study in the literature on how motor skills will be affected with musical accompaniment. The aim of this study is to compare motor skills performed with and without music in children with ADHD. When we evaluate motor skills like in a treatment session, the usability of music as an environmental factor will be investigated according to the positive, negative or ineffective results of the music effect. |
ZEHRA GÜÇHAN; | 2023-06-01 |
| 246 | Psychiatric Orders in Psychoanalytic Treatment of ASD Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is often accompanied by a variety of other symptoms, such as bipolar disorder, Attention Deficit Hyperactivity Disorder (ADHD), Social Anxiety Disorder (SAD), Avoidant Personality Disorder (AvPD), Obsessive Compulsive Disorder (OCD), etc. The behavioral and social complications often marginalize the population, impact on life satisfaction, undermined societal values that impact on economic and financial fairness, and so forth. Furthermore, persons with ASD are neurodiverse from standardized pharmacological and clinical cares, … |
YANG I. PACHANKIS; | 2023-06-01 |
| 247 | Smartphone-Based Neurobehavioral Assessments As A Diagnostic Aid in Autism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Retrospective case-control study to assess the diagnostic accuracy in autism spectrum disorder (ASD) of a new smartphone-based platform designed to conduct neurometric evaluations by measuring facial and behavioural reflexes. |
BLINKLAB | 2023-05-15 |
| 248 | Effect of Virtual Reality-based Training on Postural Control in Youth With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the effect of short-term (3 days/week for 2 weeks) Virtual Reality (VR) active video gaming intervention on static and dynamic balance, versus traditional balance training exercises, in youth with ASD. The participants in the intervention group will engage in VR active video gaming using the Nintendo Switch Sports under supervision via Zoom for 6 sessions occurring over 2 weeks, from their home. While, the participants in the control group will engage in standard physical therapy exercises for balance and walking under supervision via Zoom, for 6 sessions occurring over 2 weeks, … |
GEORGIA FREY; | 2023-05-15 |
| 249 | The Effect of Tidal Model-Based Psychiatric Nursing Approach Applied on Mothers of Children With Autism Spectrum Disorder of Internalized Stigma and Psychological Well-being PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effect of Tidal Model-based psychiatric nursing approach on internalized stigma and psychological well-being in mothers of children diagnosed with ASD. The main question[s] it aims to answer are: [Is the Tidal Model-based psychiatric nursing approach effective on the internalized stigma of mothers with children diagnosed with ASD?] [Is the Tidal Model-based psychiatric nursing approach effective on the psychological well-being of mothers with children diagnosed with ASD?] Data will be collected through scale forms and face-to-face individual interviews. Within the scope of the pre-test application, … |
ZAHIDE GÜL YAZGI DEMİR; | 2023-05-12 |
| 250 | Emotional Regulation to Manage Anxiety and Anger in Individuals With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to learn about and manage emotions such as anxiety and anger. The activities are aimed at identifying and managing emotions such as anxiety and anger, through the recognition of the changes that occur at a physiological, cognitive, behavioral and communicative level. In the first sessions, children will be exposed to the emotion of happiness through pleasant activities and involved in relaxation exercises. In subsequent sessions, anger and then anxiety will be addressed first. Social tools will be introduced and ways of thinking and perspective useful to children will be addressed. Furthermore, … |
FLAVIA MARINO; | 2023-05-10 |
| 251 | Parent-Mediated Intervention for Families With Children With Autism and Feeding Challenges, Australia Cohort PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal is to expand a parent-mediated intervention for feeding challenges in children with autism with an Australian cohort, building on recent research and current successful models already being used. A parent-mediated intervention would primarily occur in the home environment, working with the parent to establish goals and implement the intervention based on their child’s specific needs. |
KARLA K AUSDERAU; | 2023-05-01 |
| 252 | Investigating Autism Clinical Risk Factors With Profiling The Intestinal Microbiome and Metabolome Analysis and Their Impact on Disease Severity and Clinical Outcomes in Autistic Egyptian Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The role of gut microbiome was recently raised in the pathogenesis of neurodevelopmental disorders including autism spectrum disorder (ASD). In view of these evidences, together with poor conductance of researches on gut microbiota in ASD patients in Egypt, in addition to the absence of definite medical test or biological marker for diagnosis of ASD, … |
SARA ELADAWY; | 2023-05-01 |
| 253 | Effect of Nutrition and Oral Hygiene Education Using Telehealth on Diet Diversity, Nutrition Literacy and Oral Hygiene Practices in Children With Autism: A Mixed-method Stud PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional study is to assess the knowledge of caregivers of children with Autism Spectrum Disorder (ASD) regarding oral and nutritional health and the burdens they encounter in dealing and caring for these children. The main aims to answer are: Educating caregivers on – Diet diversities – Improving oral health habits Participants will have to – Fill questionnaires – Undergo educational sessions – Fill post education questionnaires Researchers will compare pre and post educational questionnaires to see if the intervention makes a difference. |
ALIYA HAIDER; | 2023-05-01 |
| 254 | A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Investigate The Efficacy and Safety of JZP541 in Adults With Irritability Associated With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Behavior dysregulation is commonly associated with people with autism spectrum disorder (ASD). Irritability is a major safety concern in adults with ASD. This study will assess the efficacy and safety of JZP541 in the treatment of adults with irritability associated with ASD. |
JAZZ PHARMACEUTICALS | 2023-05-01 |
| 255 | Virtual Reality Technology For Cognitive Functions Of Children With Down Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to identify the effect of fully-immersive virtual reality technology on cognitive functions of children with Down syndrome |
AYMAN KAMAL ELBORAEY; | 2023-05-01 |
| 256 | Effect of Picture Exchange Communication System in Improving Oral Hygiene Status Among Preschool Children with Autism Spectrum Disorder-A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Oral health is an important part of overall health of the children and precisely it is additionally imperative for children who need out of the ordinary or special health care. Children with autism spectrum disorder normally face trouble in maintenance of good oral hygiene due to their incapacity to communicate and interact socially and are one such group lacking sufficient oral health knowledge to sustain their oral health owing to communication barriers. Objective: To assess and compare the effect of Picture Exchange Communication System (PECS) intervention on oral hygiene status of preschool children (aged 4 to 6 years old) with Autism Spectrum Disorder (ASD) over a period of three months. Methods: Children with confirmed diagnosis of autism will be randomly divided into two groups. All the participants of both the groups, intervention (Group I) and control (Group II) will receive conventional oral hygiene instructions in presence of their parents. These instructions will be given on model, showing each surface to be cleaned properly. Tooth brushing with the Horizontal Scrub Technique will be promoted and performance of brushing twice daily for 2 minutes. Moreover, instruction to avoid sugary diet will also be given. Additionally, the intervention participants (Group I) will be provided a set of 10 picture cards depicting brushing sequences and techniques by animated character for PECS intervention. The plaque scores will be recorded in the two groups by using PI index by Silness & Loe (1964), GI scores will also be recorded by using GI index Loe & Silness (1963) using a periodontal probe at baseline. Following the initial examination, oral health education will be given on model to both groups, in addition to this (Group I) will be demonstrated to use PECS intervention. After three months follow up visit will be conducted in which plaque and gingival scores will be recorded again in both groups to assess the impact of PECS intervention on oral hygiene status of children with ASD. |
SAQIB MINHAS; | 2023-05-01 |
| 257 | Sensory Integration Therapy in A Sample of Children With Autism Spectrum Disorder; An Outcome Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine the effects of therapy in sensory rooms with multisensory environment on the severity of autism spectrum disorder and stereotyped and repetitive behaviours in a sample of Egyptian children with autism spectrum disorder |
RAHAF MOHAMED ABDELRAHMAN; | 2023-05-01 |
| 258 | Expanding Interventions for Automatically Maintained SIB Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to demonstrate feasibility of procedures and compare the outcomes of intervention arrangements to reduce sensory based self-injurious behavior exhibited by individuals with intellectual and developmental disabilities. The main question[s] it aims to answer are: (1) Demonstrate ability to meet enrollment requirements. (2) Evaluate acceptability and feasibility of participation relative to observation length and study duration. (3) Track and compare participant progress across interventions. (4) Demonstrate acceptable procedural fidelity and interobserver agreement. And (5) conduct post hoc evaluation of clinical presentation and intervention match. Participants will [describe the main tasks participants will be asked to do, treatments they’ll be given and use bullets if it is more than 2 items]. If there is a comparison group: Researchers will compare [insert groups] to see if [insert effects]. |
JOEL E. RINGDAHL; | 2023-04-18 |
| 259 | Enhancing Social Relations: Training Protocol for Children With ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The following protocol was developed with the intention of significantly improving social skills by focusing on increasing relationship skills among children with ASD. Divided into two distinct parts, Basic Social Relationships and Intermediate Social Relationships, the protocol has 4 stages for the former and 5 stages for the latter. Each phase is preparatory to the next, and in addition, a teaching procedure is implemented that adopts three prompt levels (partial, moderate and total), … |
FLAVIA MARINO; | 2023-04-17 |
| 260 | Effectiveness of Chinese Handwriting Intervention Program for Children With ASD: A Randomized Crossover Trail PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research aims to investigate the effectiveness and acceptability of the newly developed Chinese handwriting performance intervention program |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2023-04-07 |
| 261 | Disorders and The Effect of Corresponding Treatment on The Quality of Life of Children and Adolescents With Autism and Their Caregivers PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study mainly investigated the incidence of eye diseases in children with autism spectrum disorder(ASD) in Tianjin area, and analyzed related risk factors, so as to raise attention to eye diseases in children with ASD. To evaluate the impact of ophthalmic treatment on the quality of life of children with autism and their primary caregivers. |
TIANJIN EYE HOSPITAL | 2023-04-01 |
| 262 | Evaluation of Serum Adrenal Androgens Among Prepubertal and Pubertal Boys With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unclear etiology. There are theories depicting the importance of sex steroid hormones in autism, since the prevalence of the disorder is male-biased. What makes boys more vulnerable to achieve the diagnosis of autism remains unclear. One of the theories strengthens the importance of fetal organizational effect of testosterone on brain development. Baron Cohen with coworkers showed that elevated fetal levels of several androgens including testosterone were high in male-fetuses who later in postnatal life achieved the diagnosis of autism and fetal testosterone levels were positively correlated with autistic traits in general population. Females with conditions of abnormal prenatal exposure to testosterone and its sex steroid precursors, such as congenital adrenal hyperplasia and polycystic ovary syndrome, were found to have higher rate of autistic traits as well as their children were of higher risk of developing autism. However, the exact mechanism by which these hormones influence the manifestation of autistic traits remains undiscovered. Another model explaining higher prevalence of ASD in males is a female protective model which suggests that multiple genetic factors contribute to the development of ASD and that higher threshold of genetic liability is required in females compared to males. Zhang et al. demonstrated genetic evidence of sex differences in ASD confirming female protective model, employing investigation of de novo mutations, common variants of ASD candidate genes and their co-expression in male and female brain. During infancy: The Gonadotropin releasing hormone (GnRH) pulse generator is reactivated by 6 to 10 days after birth. This period, termed the mini puberty of infancy, was first described in the 1970s. During mini puberty, luteinizing hormone (LH) levels approximate pubertal concentrations, reaching a peak between 16 and 20 days of life. Serum testosterone levels rise in response to rising concentrations of LH, paralleling an increase in Leydig cell number and testicular testosterone concentrations. Serum testosterone levels peak from 1 to 3 months (210 ± 130 ng/dL or 7.28 ± 4.51 nmol/L on day of life 30) and decline by roughly 50% per month reaching prepubertal levels by 7 to 12 months of age. Dihydrotestosterone (DHT) concentrations parallel the rise in testosterone, reaching pubertal values during the early postnatal period. During puberty: Testosterone is produced primarily by the testes, though a small amount is also made in the adrenal gland. Gonadarche refers to the onset of sex steroid production from the gonads and occurs in response to pulsatile production of GnRH from the hypothalamus, which in turn stimulates production of LH and Follicle stimulating hormone (FSH) from the pituitary gland. LH stimulates the Leydig cells to produce testosterone, whereas FSH stimulates the Sertoli cells to proliferate and initiate spermatogenesis. Active androgens are synthesized via two alternative pathways. The first of them is known as the classic frontdoor pathway with pregnenolone serving as androgen precursor, which underwent a conversion to DHEA and subsequently to androstenediol. These metabolic steps are catalyzed by CYP17A1 (in the C17,20-lyase step) and (mostly adrenal) AKR1C3 enzyme, respectively. Dehydroepiandrosterone (DHEA) and androstenediol are readily sulfated by SULT2A1 in adrenal cortex and their sulfates serve as the stock pool for the production of active androgens of the adrenal origin as the production of androgens in early childhood of boys is limited to extra-gonadal tissues, such as adrenal, skin, etc. These sulfated primary androgens may be subsequently deconjugated and metabolized by HSD3B1 and HSD3B2 isoforms to androstenedione and Total testosterone (TST) and then to 5α/β-reduced 17-oxo- and 17β-androgens, respectively. In addition, the androstenedione may be readily converted to testosterone by adrenal AKR1C3. From the aforementioned substances, TST, 5α-dihydrotestosterone, and 11-oxo-testosterone are known as the most potent bioactive androgens. Besides the frontdoor pathway the dihydrotestosterone may be also formed by so called backdoor pathway. This pathway is based on a direct conversion of 5α/β-reduced pregnane steroids (C21) to their 5α/β-reduced androgen (C19) metabolites which is catalyzed by the same enzyme converting pregnenolone to DHEA (CYP17A1 in the C17,20-lyase step). These 5α/β-reduced androgen (C19) metabolites include also the most active androgen 5α-dihydrotestosterone. The backdoor pathway is crucial for androgen synthesis in marsupials but may also be active in various human steroid-related disorders. |
SALMA SAMIR ISMAIL; | 2023-04-01 |
| 263 | BABY@NET: A Technology-based National Surveillance Network for The Early Identification of Autism Spectrum Disorder and Other Neurodevelopmental Disorders in At-risk Populations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance. ASD resulted in 4.31 million (95% UI 2.82-6.23) global Disability-Adjusted Life Years (DALYs) in 2019, … |
MARIA LUISA SCATTONI; | 2023-04-01 |
| 264 | Effects of Early Trauma on Neurocognitive Development and Mental Health PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to learn more about how early life experience influences the brain, behaviour, and the immune system later in life. This will help improve understanding of why certain early life experiences (e.g., adoption, stress and parental separation) can cause difficulties for some people when they are adults. The long-term goal of this research is to develop tools that could identify young people who are vulnerable to developing future problems, this will ensure people get the help that they need at the right time for them. This study will use psychological assessment, online games, … |
REBECCA ELLIOT; | 2023-04-01 |
| 265 | Crossover Trial of Cannabidiol (CBD) Versus Placebo for Psychiatric Presentations in Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There are no FDA approved treatments for use in adults with autism spectrum disorder (ASD), many of whom have distressing anxiety, mood disturbances, sleep problems, and agitation. Some researchers and individuals with ASD have noted that cannabidiol (CBD) is beneficial for those psychiatric problems. This study is to learn more about the effectiveness and safety of CBD in the treatment of psychiatric problems in adults with ASD. The study will last 14 weeks total, during which six weeks participants will receive a pill containing CBD, two weeks where participants will receive no drug/placebo, … |
ELIZABETH WISE; | 2023-04-01 |
| 266 | A Prospective, Multi-Center, Longitudinal Study of Dynamic Quantification of Social-Visual Engagement (DQSVE) For Treatment Monitoring In Children With Autism Spectrum Disorder (ASD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to learn about the utility and performance of the EarliPoint(™) System: Evaluation for Autism Spectrum Disorder to monitor changes in a child’s verbal ability, non-verbal learning, … |
EARLITEC DIAGNOSTICS | 2023-03-31 |
| 267 | A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess The Efficacy, Safety, and Tolerability of Dexpramipexole Administered Orally for 52 Weeks in Participants With Severe Eosinophilic Asthma PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this clinical study is to investigate the safety, tolerability, and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma. |
MICHAEL E. WECHSLER; | 2023-03-27 |
| 268 | The Importance of Sleep for Diabetes Associated Tasks and Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Adolescents with type 1 diabetes (T1D) experience more disturbed sleep and there is some evidence that they spend less time in deep sleep compared to their healthy peers, potentially impacting diabetes management. Disturbed sleep may adversely affect diabetes management which requires day-to-day decision-making, emotional and behavioural regulation, attention, and planning. Despite a massive increase in new technology, more than 50% of adolescents do not reach their glycaemic target. Lack of sleep impairing diabetes management including blood glucose monitoring may play an important role in reaching the goal. For approximately 4000 children and adolescents in Denmark living with T1D, … |
JANNET SVENSSON; | 2023-03-27 |
| 269 | The Impact of A Virtual Magic Trick Training Program on Social Emotional Functioning in Adolescents with Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed project will attempt to confirm the benefits of a structured magic trick training program (MTTP) experience in adolescents with autism. Benefits of participating in a 6-week virtual MTTP will be evaluated using validated assessments to measure social-emotional competencies. |
HON K. YUEN; | 2023-03-27 |
| 270 | How Related Are Speech Production and Reading? An Investigation of The Impact of Motor Tasks and Lidocaine on Reading Unfamiliar Words in Adults With and Without Dyslexia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Recent claims report that reading ability is partially dependent on speech production. While the evidence for this claim is compelling, it is not known to what extent, the speech production system contributes to successful reading performance in adult populations with dyslexia. One direct way to determine the influence of speech production feedback on reading performance is to measure reading performance in adults with dyslexia with an added motor component (i.e., sucking on a lollipop, holding a bite bar or numbing their oral mucosa with lidocaine). To adults with and without dyslexia 18 years of age and older (60 in total; … |
UNIVERSITY OF ALBERTA | 2023-03-27 |
| 271 | Validation Study of The Coping, Motivation Ans Post-diagnosis Psychoeducation Program for Adults With Autism : A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to evaluate the effectiveness of a post-diagnostic psychoeducational intervention in increasing the sense of self-efficacy of adults diagnosed with Autism Spectrum Disorder-Without associated Intellectual Disability |
ERIC BIZET; | 2023-03-20 |
| 272 | Acceptance and Commitment Therapy for Stress Reduction in Caregivers of Children With Autism Spectrum Disorder: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Parents/Caregivers of children with autism need psychological flexibility and self-efficacy for the ACT program to be effective. This study will compare intervention differences between groups. Repeated measures will be given three times (pre-intervention, post-intervention, and follow-up) to an ACT intervention group and a support group (control). The purpose of the present study is to compare the effects of a brief ACT-based workshop for parents of children with autism with a concurrent parent support control group using a variety of self-report measures addressing psychological flexibility, depression, thought suppression, cognitive fusion, positive aspects of caregiving, stress, self-compassion, and valued living. |
FIELDING GRADUATE UNIVERSITY | 2023-03-19 |
| 273 | Mind The Heart – Mental Health in Children and Adolescents With Congenital Heart Defects in Denmark PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the Mind the Heart study is to document the feasibility of an online parent/child administered screening model for mental disorders (MDs) in Danish children and adolescents with congenital heart disease (CHD). As MDs in children and adolescents with chronic somatic health issues are frequently underdiagnosed and undertreated, we further aim to develop a website with evidence based information on mental health in children and adolescents with CHD in order to promote knowledge and awareness among families and health professionals across sectors. |
SARA HIRANI LAU-JENSEN; | 2023-03-17 |
| 274 | Videoconferencing-based Focused Acceptance and Commitment Therapy for Parents of Children With Special Health Care Needs: A Non-randomised Controlled Feasibility Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the proposed non-randomized waitlist-controlled design study is to evaluate the feasibility, acceptability, and potential effectiveness of using a Videoconferencing-based Individual Focused Acceptance and Commitment Therapy (FACT) approach to enhance the mental well-being of parents of children with special healthcare needs (SHCN) over a three-month period after the intervention has taken place. |
YUEN YU CHONG; | 2023-03-15 |
| 275 | Early Treatment for Children With Mental Health Problems and Genetic Abnormalities Through A Parenting Intervention (The GAP): A Pragmatic Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The GAP study is a randomized controlled trial that aims to determine the feasibility and efficacy of the Incredible Years Autism Spectrum and Language Delays (IY-ASLD®) intervention for families of children with developmental problems from a genetic basis. It is a multicentric trial where families will randomly be assigned to the intervention group or to a control group (they will follow their usual treatment). The intervention will be carried out in an online format, … |
LAIA VILLALTA; | 2023-03-14 |
| 276 | Influence of Virtual Reality Rehabilitation Training on Posture Control in Children With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Children with ASD have poorer postural balance when compared to normal individuals. So, The aim of this study is to assess the effect of Virtual Reality on postural control in Autistic children |
MOHAMED A. ABDEL GHAFAR; | 2023-03-10 |
| 277 | LifeFirst Supporting Wellbeing Among Adults By Stopping Tobacco Habit PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to promote tobacco cessation among adults in high-reach, low-resource community settings in Mumbai, India. Tobacco use is a major driver of cancer deaths and as of 2017, about 267 million individuals use smokeless and/or smoked tobacco in India. One of the WHO-endorsed evidence-based practices for tobacco cessation is brief advice interventions, which involve screening for tobacco use, advising patients to quit, and referring them to treatment. While these interventions often include medication for tobacco cessation in higher-income countries, such treatments can be an expensive and impractical solution in low- … |
SHOBA RAMANADHAN; | 2023-03-01 |
| 278 | Personalized Brain Functional Sectors (pBFS) Guided Precision Neuromodulation Treatment for Autism Spectrum Disorder (ASD): A Single-center, Sham-controlled, Double-blinded, Randomized Clinical Trial Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the neuromodulation (i.e., iTBS) effectiveness for treating autism spectrum disorder (ASD) by targeting at the pBFS-guided executive function brain network or social brain network. |
CHANGPING LABORATORY | 2023-03-01 |
| 279 | Effect of Multisensory Environment Room on Behavior in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate the effect of multisensory environment room on behavior in children with autism spectrum disorder age 3-5 years old. The children will be randomized into 2 groups: the experimental and the control group. The control group will be educated about the autistic and hoe program training. The intervention group will got the same educational program as the control group plus training in multisensory room environment once a week for 10 weeks. The outcome measurement was done as the before intervention, at the 5th and 10th week. |
SIVAPORN VONGPIPATANA; | 2023-03-01 |
| 280 | MOTOR PROFICIENCY in RELATION to COGNITIVE FUNCTIONS and SEVERITY in CHILDREN with AUTISM SPECTRUM DISORDERS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate the relationship between cognitive function, the severity of autism spectrum disorder (ASD), and the development of fine and gross motor skills in children with ASD |
AYA GAMAL ALI ABDELMONIEM; | 2023-03-01 |
| 281 | Proposal for An Adaptation of Linehan’s Biosocial Model to Emotional Dysregulation in Autism Spectrum Disorder: Narrative Review of The Literature and Clinical Case Related Papers Related Patents Related Grants Related Experts View Highlight: Linehan’s biosocial model conceptualizes the factors at play in the development of emotional dysregulation (ED), that is, difficulty regulating one’s emotions, in borderline personality disorder (BPD). The model explains ED as the result of the interaction between the person’s biological emotional vulnerability and their exposure to early invalidating experiences from those around them. Recently, ED has been shown to be prevalent in autism spectrum disorder (ASD). The objective of the study is to propose an adaptation of Linehan’s model to the specificities of ASD to conceptualize the factors contributing to ED in the context of this disorder. To do this, … |
LUISA WEINER; | 2023-02-21 |
| 282 | Psychometric Validation of The Camouflaging Autistic Traits Questionnaire (CAT-Q/DE) in A German Population of Autistic and Non-autistic Adolescents PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: For many affected individuals, despite impairment and distress, autism spectrum disorder (ASD) is recognized and diagnosed late, in school age, adolescence, or even in adulthood, which could be due, among other things, to the use of compensatory strategies such as so-called camouflaging by the respective individual. In order to better investigate and quantify these adaptive and compensatory strategies of individuals with autism, the Camouflaging Autistic Traits Questionnaire (CAT-Q) has recently been developed and validated in the English-speaking world. The CAT-Q is designed to assess the extent of camouflaging behavior, … |
JOHANNES BOETTCHER; | 2023-02-20 |
| 283 | A Randomized Controlled Phase II Study to Assess The Efficacy of Floreo VR Building Social Connections Vs. Active VR Exposure Control As Treatment for Social Skills in Autistic Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Randomized Controlled Phase II study to assess the efficacy of Floreo VR (Virtual reality) Building Social Connections as treatment for social skills in children with Autism Spectrum Disorder (ASD) |
FLOREO | 2023-02-15 |
| 284 | Cortical Contributions to Frequency-Following Response Generation and Modulation; Post-Operative Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to better understand cortical contributions of the human temporal lobe to the frequency-following response. Frequency-following responses (FFR) are electrophysiological recordings that reflect phase-locked activity of neural ensembles in the auditory pathway and are used as an indicator of the integrity of supra-threshold speech processing. FFR was first studied in subcortical areas, … |
TAYLOR ABEL; | 2023-02-14 |
| 285 | The Effect of Physical Activity on The Response of Autonomic Nervous System in Individuals With Autism Spectrum Disorders of Different Age Groups PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the effect of physical activity on autism spectrum disorder (ASD) in individuals with ASD of different age groups through measuring the hemodynamic, heart activity and respiratory system parameters. |
MOHAMMED MOUSTAFA; | 2023-02-12 |
| 286 | Testing The Efficacy of An Adapted Family-Centered Autism Transition Intervention in A Safety Net Hospital Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized controlled trial will be conducted to determine the effects of an adapted family-centered autism transition intervention called Transitioning Together/Juntos en la Transición on meaningful outcomes for families. The study will occur in a safety net hospital setting. The adapted version of this multi-family group psychoeducation intervention is delivered across one individual family joining session and four 2.5 hour multi-family group sessions. The parent and youth groups are held in separately, at the same time. |
JOCELYN L KUHN; | 2023-02-10 |
| 287 | The Use of Home Spirometry in The Monitoring of Patients With Acute Exacerbation of Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After outpatient clinic visit, asthmatic patients with worsening of symptoms (including dyspnea, wheezing, chest tightness, cough, activity limitation, awaken in the midnight due to discomfort) and are diagnosed of acute exacerbation by physician, will be recruited. The patients are asked to record symptoms using asthma symptom diary (ASD) with home spirometry simultaneously for 14 days. Visit 1 (day 1) All patients will be evaluated the following: 1. Record the patients’ demographics (age, gender, race), baseline characteristics, comorbidities, health care resources use (visits, lab tests, hospitalization and cost), pharmacological and non-pharmacological treatments 2. Blood sampling for eosinophils, … |
CHANG GUNG MEMORIAL HOSPITAL | 2023-02-07 |
| 288 | Connecting Breath and Mind: Development of An Online Holistic Treatment Programme Connecting Psychological Wellbeing and Breathing Techniques in Children and Young People With Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Recruitment target: Phase I: Co-design of intervention: 5 to 15 CYP aged between 12-18 years of age referred to the pan-London long COVID MDT. Phase II: Randomised pilot: 40 patients (12-18 years) will be recruited from a potential pool of 214 patients referred to the pan-London long COVID MDT. Methods: Phase I: Co-design Design and setting The intervention will be co-designed with CYP following a process informed by practice-base evidence, which centres the voices and wisdom of CYP, focuses on creativity and playfulness, … |
ROYAL BROMPTON & HAREFIELD NHS FOUNDATION TRUST | 2023-02-03 |
| 289 | Contribution of Animal-assisted Intervention in Oral Healthcare for Disabled Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether animal-assisted therapy during 2 care sessions then facilitates conventional ambulatory management without animal assistance in anxious uncooperative children with autism. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-02-01 |
| 290 | The Effect of Mindfulness-Based Self-Compassion Education Given to Parents of Children With Autism Spectrum Disorder on Stress, Psychological Resilience and Well-Being PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autistic Spectrum Disorder (ASD) is an important public health problem in our country as well as all over the world. The physical, psychological, social and economic problems and mood disorders experienced by the parents of these children can negatively affect not only themselves, but also the effectiveness of the intervention and treatment programs applied to the children. Therefore, many mindfulness-based intervention programs aim to improve stress reduction, resilience and well-being in parents. In this study, it is aimed to evaluate the effect of mindfulness-based self-compassion training given to parents of children with ASD on stress, … |
MINE CENGİZ; | 2023-02-01 |
| 291 | The Effect of Parenting With Positive Behavior Interventions on Community Inclusion for Military Connected and Dependent Children With Autism and Their Parents PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to find out if a training program for parents with military dependent or connected children with autism (ASD) who have challenging behavior will help those children and their families participate in more community activities. The training program, called Parenting with Positive Behavior Interventions, may help military parents learn new tools that will help their children with autism and challenging behavior attend community activities more easily. |
LAUREN AVELLONE; | 2023-02-01 |
| 292 | Investigating The Impact of An Emotional Stress Alarm App (KeepCalm) on Managing Stress and Preventing Challenging Behaviors in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: School-based behavioral approaches to managing challenging behaviors in children with ASD are limited by three key factors: 1) children with ASD often have difficulties communicating their emotions; 2) it is challenging to implement evidence-based, personalized strategies for individual children, and; 3) it is difficult for teachers to track which strategies are successful for individual children. The investigators’ personalized mobile-health emotion regulation application (m-health app) will pair heart rate tracking with digital tools to help reduce challenging behavior by supporting stress detection, reminding teachers of specific behavioral strategies and helping teachers to track progress. |
UNIVERSITY OF PENNSYLVANIA | 2023-02-01 |
| 293 | The Effectiveness of Using Daily Living Skills and Sensory Integration Training Combined With Executive Function Strategies for Improving Self-Care, Sensory Integration and Fine Motor Skills in Children With ASD in Qatar: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test if using what is called executive function strategies like strategies for improving self-regulation ,strategies for improving planning and problem solving work well when applied within occupational therapy treatment program for children who is diagnosed with Autism Spectrum Disorder , the study will compare between applying regular occupational therapy alone and applying regular occupational therapy plus executive function strategies in improving children with autism spectrum disorder , they will be two group in the study: first group called control group and second group called intervention group, … |
BARA YOUSEF; | 2023-02-01 |
| 294 | The Effect of Occupational Therapy and Sensory Integration Approach Supported Digital Storytelling on Facilitating Social Participation of Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Given the interest of children with Autism Spectrum Disorder (ASD) in using computers, this study examined the effect of Digital Storytelling (DST) activity on increasing activity participation and self-regulation. In this study, children with ASD and typically developing children were allowed to participate in DST workshops together. Selection of children intervention Children diagnosed with ASD and typically developing children attending Zeytinburnu Municipality Family Women Support and Disability Center (AKDEM) were included. The study was completed with a total of 15 children with ASD and 12 children with TD. In person-centered occupational therapy training with sensory integration, … |
REMZIYE AKARSU; | 2023-01-20 |
| 295 | A Multilevel Approach to Assess The Involvement of Gut Microbiome in Autism and Childhood Stress Regulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Using a metabolomics approach in combination with eye-tracking data, this research study proposes to gather evidence from two interrelated body systems (gut and brain) in order to assess how the microbiome is involved in stress modulated symptoms in children with autism and children exposed to repeated stress in comparison to a control group. |
GESULLA CAVANAUGH; | 2023-01-12 |
| 296 | Investigation of The Effect of Ayres Sensory Integration Therapy on Occupational Performance in Children With Autism Spectrum Disorder: A Randomized Control PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ayres Sensory Integration (ASI) Therapy is an individualized intervention designed to address specific underlying sensorimotor issues that may affect children’s performance during daily routines and occupations. The intervention takes place in the context of play, emphasizes the active participation of the child, involves a collaborative relationship between the occupational therapist and the child, and focuses on participation-oriented outcomes that are collected at regular intervals throughout the intervention program. In general, its content is to improve the child’s occupational performance. The program, which will be carried out in accordance with the Ayres Sensory Integration Fidelity Measure®, … |
ZEYNEP ÇORAKCI; | 2023-01-06 |
| 297 | Pilot Randomized Controlled Trial of A Telehealth Mindfulness-based Intervention for Adolescents With Autism Spectrum Disorder and Their Caregivers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will evaluate the effectiveness of MINDful TIME, an 8-week mindfulness-based program designed to improve mental health in adolescents with autism spectrum disorder and their caregivers. MINDful TIME includes weekly psychoeducational group meetings conducted through videoconferencing and use of a commercially available mindfulness meditation app. We predict that adolescents in the mindfulness intervention group will demonstrate increases in self-reported mindfulness and reductions in self- and parent-reported anxiety and depression relative to a delayed treatment control group. We will also explore whether caregivers in the treatment group demonstrate improvements in quality of life. |
NICOLE MATTHEWS; | 2023-01-04 |
| 298 | Promoting Communicative Initiative in Minimally Verbal Autistic Children Through Interaction with The Humanoid Social Robot PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Minimally verbal (MV) children with Autism Spectrum Disorder (ASD) face significant challenges in communication and social interaction, which are fundamental to learning and development. Current therapeutic approaches, such as speech therapy and augmentative communication systems, often have variable efficacy due to engagement and responsiveness challenges. This pilot study investigates using of the humanoid robot NAO as part of a rehabilitative program designed for MV children with ASD. NAO, with its predictable and engaging interaction style, is hypothesized to enhance communicative initiative, expressive communication, and social interaction in this population. The study employs a randomized controlled trial design, … |
FRANCESCA CUCINOTTA; | 2023-01-02 |
| 299 | A Crisis Prevention Program in Youth With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mental health crises involve acute psychiatric states, such as aggression and/or self-injury, which can result in harm to self or others. There is evidence to suggest that 20% to 25% of autistic children are at risk of a mental health crises, however no crisis prevention programs exist for autistic children. The goal of this project is to evaluate, via a randomized design, a novel crisis prevention program. |
LUTHER KALB; | 2023-01-02 |
| 300 | Quantitative EEG Neurofeedback As An Add-on Therapy For Attention-deficit Hyperactivity Disorder (ADHD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Attention deficit/hyperactivity disorder (ADHD) is a common neurological disorder in children, mainly manifesting as attention deficit, excessive hyperactivity, and impulsivity. It is a chronic condition that affects millions of children and often continues into adulthood. The prevalence of ADHD in the worldwide is approximately 5%, predominantly occurring in boys, and more than half of patients continue to experience symptoms into adulthood. Children with ADHD have moral disorders and learning difficulties, and these factors will seriously affect their academic achievements and familial and social relationships; thus, treatment is necessary. Currently, the treatment for ADHD is usually pharmacological intervention, such as methylphenidate, … |
MOHAMED EMAD ELDEEN MAHMOUD; | 2023-01-01 |
| 301 | Biomarkers of ADHD Treatment Response PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this translational biomarker study is to use electroencephalography (EEG) to identify brain signatures that will predict a child’s response to two of the most commonly prescribed ADHD medications, … |
ANNE ARNETT; | 2023-01-01 |
| 302 | The Effectiveness of An Autistic-delivered Peer-support Intervention for Autistic Adults: Community Autism Peer Specialist (CAPS) Program PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The number of autistic adults reached 5.4 million in the United States in 2017 and is projected to continue to rise, but evidence-based practices to optimize their health and well-being are limited and poor outcomes are common. This study will leverage existing infrastructure to finalize the development of a novel support service provided by peers with lived experience, incorporating input from autistic peer specialists, autism researchers, peer support researchers, and experts in peer support training. Investigators will then conduct a pilot randomized controlled trial to examine the effectiveness of the service while also examining the feasibility, acceptability, … |
LINDSAY SHEA; | 2023-01-01 |
| 303 | Comparing The Effectiveness of Physical Exercise and Melatonin Supplement in Treating Sleep Disturbance in Children With ASD: A RCT Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This RCT study aims to compare effectiveness physical exercise and melatonin supplement on treating sleep disturbance in children with ASD. A four-arm randomized controlled trial with equal allocation ratio to the three intervention groups (i.e., jogging; melatonin supplement, combine jogging and melatonin supplement) and one placebo-control group will be conducted . Actigraph device and sleep log will be used for sleep assessment. 6-sulfoxymelatonin from 24-h and first morning urinary samples. The investigators will monitor the changes of four sleep parameters (sleep onset latency, sleep efficiency, … |
ANDY TSE CHOI-YEUNG; | 2023-01-01 |
| 304 | Assessing Moral Cognitive Skills in Adults With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the international literature, it is currently accepted that, relative to neurotypicals, people with Autism Spectrum Disorder (ASD) present patterns of moral judgments marked by a minimization of intentionality and a strong condemnation of agents responsible for accidents. However, until now, all studies are based on declarative paradigms, and no one has proposed to examine the relationship of people with ASD to moral transgressions (i.e. to a bad action done deliberately or to a good deed deliberately omitted) in an implicit paradigm, that is, … |
ELODIE PEYROUX; | 2023-01-01 |
| 305 | A Strength-Based Employment Maintenance Program for Individuals on The Autism Spectrum PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are looking to evaluate how effective a training program that focuses on character strengths may be in improving job maintenance skills in young adults. The investigators are examining the effects of this intervention in young adults who feel they would like to help in improving their satisfaction with work, and in keeping their jobs. |
HELEN GENOVA; | 2023-01-01 |
| 306 | The Effects of Melatonin on Sleep Spindles in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sleep disturbances and sensory sensitivities are common disabling features of autism, but their underlying causes are not clear. We hypothesize that both of these difficulties reflect disrupted communication between a deep brain structure, the thalamus, and the brain’s outer layer, the cortex. This communication is mediated by the thalamic reticular nucleus (TRN). Due to its small size and location deep in the brain, we cannot assess TRN function without invasive techniques. Fortunately, sleep spindles, … |
DARA S. MANOACH; | 2023-01-01 |
| 307 | APP-based Emotion Recognition Training Improve ASD Social Function PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the study is to investigate whether APP-based emotional recognition training improve social function in autistic children. |
WEIHUA ZHAO; | 2023-01-01 |
| 308 | Explore The Impacts of One Session Theta Burst Stimulation Over Cerebellum in Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigator would like to investigate the impact of theta-burst stimulation over cerebellum in adults with autism spectrum disorder |
HSING CHANG NI; | 2022-12-28 |
| 309 | Effects of Sports, Play and Active Recreation for Kids (SPARK) Versus Fundamental Motor Skill Training on Social and Motor Skills in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It was a Randomized Clinical Trial.Data will be collected from Life care rehabilitation and special child facility.The study was completed within 6 months after approval of synopsis.The calculated sample size, through WHO sample size calculator, using Bruininks- Oseretsky test’s mean and standard deviation (Mean Dynamic Balance) as outcome measure was 20 in each group. After adding 10% dropout the sample size will be 20+4=24 in each group; hence, … |
KHADIJA LIAQUAT; | 2022-12-27 |
| 310 | Investigating The Unique Motor Characteristics and Corresponding Cortical Activation During Handwriting — in 5-12 Year-old Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The mechanism of the motor problem in children with autism spectrum disorder (ASD) in handwriting has been investigated in the following three aspects, including collecting dynamic handwriting performance, exploring the related underlying factors, and investigating corresponding brain activities. This study aimed to investigate the underlying factor of handwriting issue in children with ASD. There are four study aims. The first is to examine the differences of handwriting performance between children with ASD and TD using kinetic and kinematic measurements and handwriting difficulties questionnaires. The second is to investigate the group difference of the underlying motor factors, … |
NATIONAL CHENG KUNG UNIVERSITY HOSPITAL | 2022-12-27 |
| 311 | Faecal Microbiota Analysis in Neurotypical and Autism Syndrome Disorder Siblings: FAMILY PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to accurately characterise the gut microbiota composition of faeces of children with ASD and compare it with the gut microbiota composition of their neurotypical siblings. In addition it aims to also characterise the metagenome and metabolome of the faeces of both ASD and neurotypical siblings. |
BEN MARLOW; | 2022-12-20 |
| 312 | Application of Ketamine Combined With Dexmedetomidine Sedation in Magnetic Resonance Imaging of Children With Autism and Autism Spectrum Disorder:a-Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: To investigate the use of ketamine combined with dexmedetomidine for sedation in children with autism spectrum disorder, Methods:aged 2-6 years,, ASA grade I or II. The children were randomly divided into three groups using a random number table method: a low-dose dexmedetomidine group (DEXL group,n=100）The high-dose group of dexmedetomidine (DEXH group,n=100) and the group of esketamine combined with dexmedetomidine (DEXE group,n=100). The DEXL group received 2.5 μ g/kg of dexmedetomidine nasal drops, the DEXH group received 3 μ g/kg of dexmedetomidine nasal drops, … |
LI NA; | 2022-12-01 |
| 313 | Modulation of Serotonin Pathways Using Psilocybin in Adults With and Without Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test the hypothesis that brain systems are differentially regulated by serotonin in individuals with and without Autism Spectrum Disorder. |
GRAINNE MCALONAN; | 2022-12-01 |
| 314 | A Multicenter Randomized Controlled Study of The Efficacy of Oral Motor Therapy in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Children with Autism spectrum disorders have speech disorders, which in turn aggravate communication difficulties and lead to an increase in their core symptoms. This experiment attempts to investigate the efficacy of Chinese language oral motor therapy in improving various aspects of articulation, language ability, and behavior of children with autism in conjunction with the International General Autism Scale, and provides a basis for the rational formulation of clinical treatment plans. |
THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIVERSITY | 2022-12-01 |
| 315 | A Phase II/III Double-Blind, Randomised and Controlled-to-Open-Label Study Assessing The Efficacy of Full-Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) on The Severity of Autism Spectrum Disorder in Young People PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an 18 to 54 week study assessing the efficacy of Full-Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) on the severity of autism spectrum disorder in young people. |
MICHAEL FAHEY; | 2022-11-30 |
| 316 | Accuracy of Community General Pediatrician Diagnosis of Autism Compared to A Multidisciplinary Team Assessment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goals of this diagnostic study are to determine how accurate general pediatricians are in autism spectrum disorder (ASD) diagnostic assessment and which children might be best suited for this type of assessment. The investigators will also evaluate the use of a new virtual diagnostic tool, the Autism Assessment for Preschoolers with Language Element Sequence (AAPLES). The investigators will recruit twenty general pediatricians from across Ontario, Canada, as well as 200 of their patients (maximum 10 per pediatrician) who have been referred with possible ASD. The general pediatrician will complete their assessment and decide on a diagnosis, … |
MELANIE PENNER; | 2022-11-24 |
| 317 | Comparative Effectiveness of Three Devices for Transcatheter Closure of Atrial Septal Defects for Adults: A Pilot Study (Trio-ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a proposal, for the first time in Canada, to examine the comparative effectiveness of three commercially available devices (ASO, FSO, and GAO/GSO) for transcatheter closure of atrial septal defects (ASD) in adults using a pilot randomized controlled trial. |
ERIC HORLICK; | 2022-11-23 |
| 318 | Feasibility and Effectiveness of Online Peer Companion Intervention on Children With Autism Spectrum Disorders PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional study was to explore the feasibility and effectiveness of online peer companion intervention (OPCI) on the social abilities and mental health of ASD children. The main questions it aims to answer are: 1. What is the acceptability and adherence of OPCI; 2. Whether OPCI is effective on the social abilities and mental health of ASD children; 3. What impact does OPCI have on ordinary children and parents of both children? |
PEKING UNIVERSITY | 2022-11-20 |
| 319 | Virtual Mindfulness for Autistic Adults: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test the effectiveness of a virtual group mindfulness intervention for autistic adults on their mental health and well-being, compared to a group who has not received the virtual group intervention. Specifically, the investigators will compare change across multiple indicators of mental health and well-being for participants, post-intervention, and at 15 weeks follow-up, to participants in a waitlist control group who have not yet received the intervention. |
YONA LUNSKY; | 2022-11-17 |
| 320 | Single-center, Double-blind, Placebo-controlled, Randomized Clinical Trials for Safety and Efficacy Assessment of Symptoms Related to Autism Spectrum Disorder Using NuEyne P01 in Patients With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the safety and the efficacy of applying transcutaneous trigeminal nerve stimulator (NuEyne P01) on autism spectrum disorder. |
HEE JEONG YOO; | 2022-11-15 |
| 321 | Micronutrient Supplementation in Children With Autism Spectrum Disorder (ASD): A Clinical Trial Examining Mechanism of Action PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An open-label examination of changes in metabolites with use of micronutrients in children with autism spectrum disorder (ASD). Investigators will also measure behavioral measures monthly at school with teachers and parents report. |
ROBERT HENDREN; | 2022-11-14 |
| 322 | Pilot RCT to Compare A Home Based Tailored Cognitive Behavioral Therapy for Insomnia (CBT-I) Versus Webased CBT-I to Improve Sleep in Caregivers With Insomnia in The Context of Caring for A Child With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) represents one of the most perplexing neurobiological disorders with a prevalence of 1 in 54 children. The lifelong challenging and disruptive behaviors often associated with ASD requires caregivers to change their behavior and modify their environments to provide an ecosystem for optimal outcomes for their child, family and themselves. ASD behaviors can have significant impact on caregivers mental health and family functioning, including the ability to develop and maintain healthy sleep routines. The caregiving population in US has a high prevalence of insomnia; … |
UNIVERSITY OF PENNSYLVANIA | 2022-11-05 |
| 323 | A 52-Week Open-Label Extension Study of Pimavanserin in Children and Adolescents With Irritability Associated With Autism Spectrum Disorder (ASD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 52-week, open-label extension study of double-blind study ACP-103-069 to determine the long-term safety and tolerability of pimavanserin for the treatment of irritability associated with ASD in children and adolescents (aged 5 to 17 years). ACP-103-069 is a 6-week, randomized, double-blind, fixed-dose, placebo controlled, parallel group study of pimavanserin in children and adolescents with irritability associated with autism spectrum disorder (ASD). |
ACADIA PHARMACEUTICALS | 2022-11-02 |
| 324 | Color Doppler to Confirm Epidural Catheter Positioning in Parturient, Would It Help PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to calculate the sensitivity and specificity of using color Doppler with pulsed wave Doppler to accurately detect the position of epidural catheter |
RABAB MOHAMMAD HABEEB; | 2022-11-01 |
| 325 | Screening for Neurodevelopmental Disorders in Siblings of Children With Autism Diagnosed in Tertiary Centers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, a selective and multi-stages screening for neurodevelopmental disorders (NDD) in siblings of children with a confirmed ASD is done. The main aims are to estimate the prevalence of NDD among siblings and to evaluate the feasibility and acceptability of a standardized screening procedure. |
VÉRONIQUE GONNIER; | 2022-11-01 |
| 326 | The Effect of Art Therapy Applied to Mothers on Eating Behavior in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Art therapy; Art therapy is an integrative mental health service that enriches the lives of individuals, families, and communities through active art practices, the creative process, applied psychological theory, and human experience in a psychotherapeutic relationship. It is a therapeutic method used in the form of sessions to improve self-esteem and self-esteem. Art therapy used to develop emotional resilience, increase insight, develop social skills, reduce and resolve conflicts and distress seeks to both find an outlet for complex and intense emotions and It allows them to be verbally expressed at an intellectual level, … |
ELIF AKYİĞİT ALBAYRAK; | 2022-11-01 |
| 327 | Analgesic Efficacy of Bilateral Ultrasound Guided Transversus Thoracic Muscle Plane Block Versus Erector Spinae Plane Block in Pediatric Patients Undergoing Corrective Cardiac Surgeries – A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Corrective cardiac surgeries include a bundle of major surgeries that take place in pediatric patients and require imperative perioperative pain control; hence, the art of healing starts from trying to diminish or abolish pain. The use of highly potent opioids for paediatric cardiac anaesthesia has gained widespread popularity during the last 20 years . In addition to the important advantage of hemodynamic stability, the large-dose opioid-based anaesthetic techniques also blunt the stress response; however, large doses can cause over sedation, … |
ENGY I. ABUELDAHAB; | 2022-11-01 |
| 328 | Ketogenic Diet for Status Epilepticus in Infants, Children and Adolescents Aged 6 Months to 18 Years Immediately After Cessation of Convulsive Status Epilepticus; A Randomized Open Labelled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Ketogenic diet being started early in those with status epilepticus and frequent or abundant discharges in EEG in comparison to just standard therapy is being evaluated here for efficacy and adverse effects. |
SHEFFALI GULATI; | 2022-11-01 |
| 329 | Leveraging Autism Intervention for Families Using Telehealth (LIFT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the LIFT study is to develop a technology-assisted adaptation of the JASPER (Joint Attention, Symbolic Play, Engagement, and Regulation: Kasari et al., 2021) social communication intervention for young children with autism spectrum disorder (ASD). In partnership with community early intervention (EI) and early childhood special education (ECSE) practitioners in Oregon, … |
STEPHANIE Y SHIRE; | 2022-11-01 |
| 330 | Evaluating The Efficacy of Pathways Early Autism Intervention on Social Orienting, Joint Attention and Social Language: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the efficacy of Pathways parent-mediated early autism intervention (Pathways) and a parent education intervention (PEI) delivered to culturally and linguistically diverse families with children 12-42 months of age suspected of or diagnosed with autism. Question 1: Is Pathways more effective than a PEI at (a) fostering the development of social orienting, joint attention, … |
PAMELA ROLLINS; | 2022-10-27 |
| 331 | Training Intervention and Program of Support (TIPS) for Fostering The Adoption of Family-centred Telehealth Interventions in Pediatric Rehabilitation: A Pan-Canadian Implementation-effectiveness Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Timely access to family-centred services for children with disability and their families is important to support their development and well-being. Currently, many children face long wait times and barriers to services. Lack of access can lead to negative impacts for children and stress for their families. With the COVID-19 pandemic, these issues have been made more challenging with the loss of rehabilitation support for children, increasing stress on families. During this time, therapists moved to telehealth service delivery to support children and families. We know that telehealth can improve access to services, children’s outcomes, and family satisfaction, … |
CHANTAL CAMDEN; | 2022-10-17 |
| 332 | International, Multicentric, Observational Study to Characterize Subpopulations of Patients With Autism Spectrum Disorder PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine sufficient number of biological and clinical markers to identify subgroups of potential best responders to a specific medication |
CESAR OCHOA-LUBINOFF; | 2022-10-13 |
| 333 | Effects of A Multimodal Exercise Program for Children With Autistic Spectrum Disorder (ASD) on Cognitive and Motor Abilities: Part III PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Exploring the effects of an exercise program for children ages 6 -26 years old who have been diagnosed with autism spectrum disorder and neurotypical children respond to high-intensity whole body exercise interventions (Group 1), training using a sensory glove and armband (Group 2), no-intervention control (waitlist control) (Group 3). Approximately 50 children and adolescents will volunteer to participate in this program with participants parents’ (or legal guardians’) permission. This study will be conducted at an off-site pediatric occupational therapy facility Inclusive Sports and Fitness, Inc. (ISF). |
NEW YORK INSTITUTE OF TECHNOLOGY | 2022-10-12 |
| 334 | Validation Externe Par Apprentissage Statistique Et Réduction Des Dimensions D’entrée De L’échelle D-PSY PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There have been debates about whether psychiatric disorders should be classified according to categories (categorical model) or according to a continuum between normal and pathological functioning (dimensional model). While the former is the main one used to facilitate reliability, it has several limitations. We will use machine learning to develop a predictive model, bridging the gap between the dimensional and categorical approaches. Psychometric measures obtained from a questionnaire will be collected. Then, … |
AURORE VIALATTE; | 2022-10-11 |
| 335 | Training and Implementation of RUBI in Community Mental Health Settings PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project is focused on evaluating outcomes related to this statewide clinical training effort in the RUBI parent training program. Up to 400 providers in Maine are enrolling in a Level 1 16-hour RUBI introductory training through one of three modalities (1) self-paced On Demand webinars, (2) 16 weekly one-hour meetings (ECHO group); … |
KAREN BEARSS; | 2022-10-03 |
| 336 | Evaluation of An Animal Assisted Therapy Program in People With Mental Illness, for The Promotion of Positive Mental Health Behaviors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Scientific literature reports that focusing interventions on people with mental health problems, from the threshold of Positive Mental Health, is effective and allows the person to promote positive mental health behaviors. The well-known Animal Assisted Therapy is a complementary intervention used for decades that has reported scientific evidence in the field of mental health in communication, socialization, anxiety and adherence to treatment of patients. This protocol aims to create and evaluate an Assisted Therapy program with dogs in relation to the development and promotion of Positive Mental Health behaviors in people with mental illness in a community rehabilitation service. |
JUDITH BALAGUER; | 2022-10-01 |
| 337 | A Randomized, Double-Blind, Sparing-effect Placebo Controlled, With Cross-over Study to Evaluate The Safety, Tolerability and Efficacy of SCI-210 in Children With Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and efficacy of SCI-210 in the treatment of Autism Spectrum Disorders (ASD) |
GAL MEIRI; | 2022-10-01 |
| 338 | The Family Check-Up: Implementing A New Family-Centred Model Within Autism Services PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many children and youth with autism spectrum disorder have high levels of emotional and behavioural problems. Parents play a powerful role in supporting their children’s well-being. Research also shows that certain factors (e.g., parent mental health, access to services) can affect autistic children’s well-being in important ways. Despite this, autism services rarely ask about, or act upon, the factors that we know affect child and family well-being. We are addressing this problem by testing a program called the Family Check-Up within a large autism service. The Family Check-Up is a strengths-based, … |
TERESA BENNETT; | 2022-10-01 |
| 339 | Auricular Transcutaneous Electrical Nerve Stimulation Treatment of Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, investigators will examine the treatment effects of transcutaneous electrical nerve stimulation with different stimulation frequencies on individuals with autism. |
JIAN KONG; | 2022-10-01 |
| 340 | Manual Motor Planning Deficits and Performance Differences in Children With Autism Spectrum Condition: A Kinematic Analysis to Extract Objective Markers of Motor Atypia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Condition (ASC) is a behavioral syndrome characterized by a severe organizational disorder of thinking and major functions that regulate human adaptation. It is to be considered as a functional disorder, or of executive functions, whose dysfunction is expressed in the difficulty of making voluntary movements, sequentially coordinated with each other according to a purpose, and of initiating an action, planning and monitoring it by inhibiting inappropriate responses such as gesture perseveration. Literature studies suggest that, compared to children with typical development (TD) and regardless of cognitive status, … |
FLAVIA MARINO; | 2022-10-01 |
| 341 | Self-Advocacy at The University Level: Teaching Students With Autism Spectrum Disorder to Advocate for Their Needs Related Papers Related Patents Related Grants Related Experts View Highlight: Cases in autism spectrum disorder (ASD) have dramatically risen over the past 30 years, with the current rate of 1 in every 44 (Maenner et al., 2021) children born with the condition. Much emphasis rests on the need for various interventions, practices, and therapies during childhood to improve quality of life and success across a variety of settings. Nonetheless, as they age, all children advance through the education system and eventually leave the school system. Consequently, it should not be surprising that these children must grow up and face realities after high school. For some, this may include residential placements, … |
MARK TAPIA; | 2022-10-01 |
| 342 | Biomarkers Trajectories of Early Intervention in Siblings of Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project deals with essential challenges in the context of Autism Spectrum Disorder benefiting from a prospective design in childhood, early intervention and a cutting-edge experimental techniques. The present study tests the potential effect of early intervention on neural and behavioral responses in toddlers at elevated likelihood of developing autism (siblings of children with autism) who show clinical autistic signs. Four comparison groups were included in the study: (1) toddlers at elevated likelihood of developing autism with clinical autistic signs who receive early intervention from 18 to 24 months (2) toddlers at elevated likelihood of developing autism with clinical autistic signs who do not receive early intervention (3) toddlers at elevated likelihood of developing autism without clinical autistic signs who only received assessment and monitoring, and (4) typically developing toddlers who only received assessment and monitoring. This study focuses on social and nonsocial sensory integration skills (measured by electroencephalographic and eyetracking recordings) to identify reliable biomarkers for early detection and intervention of autism during a critical period of development. The characterization of biomarkers will guide the detection of the most vulnerable children that will benefit from early intervention, with the long-term aim of reducing the impact of autism on the National Health System. |
IRCCS EUGENIO MEDEA | 2022-09-26 |
| 343 | Coaching Children With Anxiety and Autism Through Telehealth PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine a telehealth parenting intervention to reduce anxiety in 20 families of children between 4 and 8 years old with autism and anxiety. Caregivers and children complete 12 telehealth treatment sessions. Caregivers and children will complete pre tests, post tests, and 3 month followup assessments that include observations, heart rate monitoring, and caregiver ratings. |
LAURA CARPENTER; | 2022-09-23 |
| 344 | Impact of Slow Breathing on Markers of Stress in Response to A Virtual Reality Active Shooter Drill PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effects of slow breathing breathing on markers of stress in healthy college aged individuals. The breathing intervention is performed for five minutes pre and post a virtual reality active shooter drill. The main question to answer is: 1) what is the impact of a controlled breathing intervention and virtual reality active shooter drill on markers of subjective and biological stress? |
MATT MCALLISTER; | 2022-09-23 |
| 345 | Repetitive Transcranial Magnetic Stimulation to Promote Helpful Self-regulatory Behaviour in Children and Youth With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the feasibility of repetitive Transcranial Magnetic Stimulation (rTMS) in Autism Spectrum Disorder (ASD) with self-regulation impairment. Baseline and follow-up participant visits will include behavioral assessments of self-regulation and magnetic resonance imaging (MRI) to determine neurophysiological outcomes before and after rTMS treatment. |
DERYK BEAL; | 2022-09-22 |
| 346 | Differential Modulation of Neural and Behavioral Responses to Emotional Scenes By Intranasal and Oral Oxytocin Administration in Healthy Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will investigate whether oxytocin administered either intranasally or orally (lingual) (24 international units, IU) can differentially modulate men’s neural and behavioral responses to emotional scenes using an implicit emotional paradigm. |
KEITH M KENDRICK; | 2022-09-20 |
| 347 | Eliminating Post-Mastectomy Pain and Opioids With Percutaneous Cryoneurolysis: A Single-Administration, Non-Opioid, Non-Addictive, Multiple-Month Analgesic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Breast cancer is the most common type of cancer in women. Removal of the breast, called mastectomy, is performed either when there is cancer-or an increased risk of cancer-in the breast. This can result in a lot of pain during the months after surgery. Opioids-narcotics-are the most common pain control method provided to patients; but they frequently do not relieve enough pain, have undesirable side effects like vomiting and constipation, and are sometimes misused which can lead to addiction. Mastectomy also frequently results in long-term pain which can interfere with physical and emotional functioning; … |
BRIAN M. ILFELD; | 2022-09-15 |
| 348 | Partners in School: Promoting Continuity Across Home and School for Children With Autism By Improving Parent-Teacher Communication During The Transition to School PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Partners in School is a collection of implementation strategies (e.g., communication training, problem-solving consultation) to help parents/primary caregivers and teachers of children with autism spectrum disorder implement the same practices across home and school. |
GAZI AZAD; | 2022-09-15 |
| 349 | The Effect of Reiki on Treatment Compliance, Eating Behaviors and Metabolic Values in Obese Individuals With Type 2 Diabetes: Randomized Controlled Study Related Papers Related Patents Related Grants Related Experts View Highlight: The increase in the prevalence of diabetes and the loss of various organs and functions in the individual as a result of complications caused by diabetes affect the life expectancy and quality of individuals, and cause social and economic losses affecting the whole society. For this reason, the individual management of the diabetic patient is important in terms of ensuring effective participation and compliance in treatment and care. Patients must have knowledge, skills and positive attitudes in order to successfully comply with diabetes treatment. Patients are in compliance with diabetes treatment; they encounter some barriers such as medication barriers, … |
FATMAZ ZEHRA KÜÇÜK; | 2022-09-15 |
| 350 | A Randomized, Double-blind, Parallel Group, Placebo-controlled Study to Investigate The Efficacy, Safety, and Tolerability of ML-004 in Adolescents and Adults with Autism Spectrum Disorders (ASD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ML-004-002 is a multi-center, randomized, double-blind, parallel-group, placebo-controlled study that will enroll approximately 150 adolescent and adult subjects with ASD. The primary objective is to evaluate the efficacy of ML-004 compared with placebo in the improvement of social communication deficits in subjects with ASD. |
MAPLIGHT THERAPEUTICS | 2022-09-13 |
| 351 | Digital-based Psychosocial Intervention for Parents of Children With Neurodevelopmental Disorders: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to implement a structured psychosocial intervention program with digital support (randomized and with a control group) that will be conducted virtually and synchronously to families of children with autism spectrum disorder (ASD) and families of children with Attention Deficit with hyperactivity Disorder (ADHD). The main questions it aims to answer are: 1. Will the program impact on different variables in the parents’ domain (parental stress variables, quality of life/social support and coping skills), 2. Will the program impact on different variables in the children’s domain (daily life functioning, social behavioral variables, … |
CARMEN BERENGUER-FORNER; | 2022-09-07 |
| 352 | BEhavioral Health Stratified Treatment (BEST) to Optimize Transition to Adulthood for Youth with Intellectual And/or Developmental Disabilities (IDD) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Many youth with disabilities and their families receive care coordination services from a state Maternal and Child Health Bureau (MCHB) agency. MCHB care coordination services help youth with disabilities get the medical care and social services they need to be healthy. Complex HEalth Care for Kids (CHECK) developed a program to combine mental health treatment and care coordination services for youth with disabilities. The goal of this study is to see whether a care coordination program that treats depression and anxiety (MCHB care coordination + CHECK) is better than a care coordination program (MCHB care coordination alone) that refers youth to mental health services in terms of making youth feel healthier, happier, and able to handle future challenges. The project team will test which care coordination approach is better at making youth with disabilities: (Aim 1) less anxious and depressed; (Aim 2) feel healthier, function better, and practice healthy habits; (Aim 3) improve their ability to manage their health. This study will also evaluate which approach makes (Aim 4) youth, caregivers, and providers feel more satisfied with their care coordination experience. This study will give youth with disabilities and their families information about what kinds of care coordination models are available, and better suited to their needs. The study team will reach out to 780 youth with intellectual and/or developmental disabilities, age 13-20 years old, who receive care coordination services from the state of Illinois MCHB. If these youth are eligible and agree to be in the study, they will be placed, by chance, into either MCHB care coordination alone or into the MCHB care coordination + CHECK program. In both groups, youth will have a care coordinator who helps them identify and make plans to meet their needs and provides referrals to services/resources. Youth in the MCHB care coordination + CHECK care coordination will get mental health treatment directly from CHECK staff if they report symptoms of depression or anxiety. Treatment may include an online program or group meetings that teach youth how to cope with negative thoughts and feelings. Youth in each group will be followed for 24 months and will receive gift cards for participating. Youth will be asked questions about anxiety and depression, health, functioning, ability to manage their health care, self-efficacy, and their experience with care coordination. |
BENJAMIN VAN VOORHEES; | 2022-09-01 |
| 353 | Abnormal Thyroid Profile in Children With Attention Deficit With Hyperactivity Disorder (ADHD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: The observational data of University Children’s Hospitals of Nice, suggest that about a quarter of children and adolescents with ADHD may present with an abnormal thyroid profile. Main objective: To confirm that a subsample of children and adolescents with ADHD present with an abnormal thyroid profile using the gold standard for free fraction of hormones : chromatography with mass spectrometry. Secondary objective: To examine to what extent this categorization holds using classic immuno-analytic assays. To characterize clinically and from a neuropsychological point of view this subsample and compare it to the other participants. Study duration and design: 30 months (24 months for inclusion and 6 months for data analyses) open-label, (category 2 : interventional research with minimal risks or constraints), multicentre, without treatment or placebo administration. Expected outcomes: Ancillary studies will investigate genetic physiopathological mechanisms (polymorphisms of deiodase or transmembrane carriers of thyroid hormones) and link this profile to other biological markers proposed in the literature (low ferritinemia, higher oxidative stress, atopic comorbid disease). The clinical trajectory of this subgroup and the persistence of this abnormal thyroid profile in adulthood will be a relevant issue in the future. |
HERVÉ CACI; | 2022-09-01 |
| 354 | Dynamic Cervical Implant (DCI) Versus Anterior Cervical Discectomy And Fusion(ACDF) For The Treatment Of Single-Level Cervical Degenerative Disc Disease (DDD): An RCT PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: TO Compare The Clinical And Radiographic Outcomes of DCI VS ACDF For The Treatment Of Single-Level Cervical Degenerative Disc Disease (DDD) |
MAHMOUD ABDELRAHMAN SALEH EL ATTAR; | 2022-08-25 |
| 355 | Exploring Caregivers’ Experiences Related to The Use of A Smart Toothbrush By Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to examine caregiver reactions to the use of the hum by Colgate Smart Kids Toothbrush and associated app by children with autism spectrum disorder (ASD). |
KATHERINE FRANCE; | 2022-08-24 |
| 356 | Parent-mediated and Telehealth Intervention for Children With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study has two purposes: Aim 1: To develop a Telehealth Early Intervention Program (TEIP) for children with ASD that will be carried out by parents at home when interact with their children; … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2022-08-19 |
| 357 | Effects of General Anesthesia on Brain Functional Connectivity and Cognition in Children With Potential Neurological Damage PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Postoperative Cognitive Dysfunction(POCD)is a common postoperative complications, existing clinical research focused on the adult patients, ignoring that the developing human brain with underlying neurological impairments may be at higher risk for cognitive impairment, so we need a prospective study, observe this kind of special groups in the brain structure and function of before and after general anesthesia, To determine the susceptibility to neurotoxicity of general anesthesia drugs. |
LAI JIANG; | 2022-08-15 |
| 358 | Use of A Telehealth Approach to Build Resilience in Parents of Children with Autism Through Mindfulness Practice PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the project is to investigate the effects of online 8-week MBSR intervention on diverse parents to support their children with ASD. The investigators will conduct a randomized waitlist-controlled trial with a sample size 22 parents. This study utilizes psychological, behavioral and psychophysiological measures with parents of children with ASD ages 6-12. The first aim is to determine if parents of children with autism from diverse populations are willing participate in and complete an online MBSR program and if online delivery is as effective as in-person program. The battery of parental-report psychological assessments to measure resilience, … |
MEGAN CHANG; | 2022-08-15 |
| 359 | Training in Neuro Strengths-Based Approach to Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Neuro-Strength-Based Approach to Autism (NSBAA) attempts to translate what research has discovered about the autistic brain into terms that autistics, and those involved with autistics, can understand. It is not intended to be a new approach to intervention but hopefully a unifying approach to understanding autism that all therapists, educators, clinicians, and parents can use when working with autistic individuals. It was developed by an autistic occupational therapist, based on her lifetime obsession of learning everything she could about how typical brains work, and, following her diagnosis, … |
BLAIR BRADEN; | 2022-08-15 |
| 360 | Promoting Inclusive Educational Environments for Children With Autism and Other Social-communication Challenges: Preschool Class and Primary School PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the effect of using the Autism Program Environment Rating Scale (APERS) as the foundation for providing feedback, in-service training and coaching to teachers, to improve program quality for autistic (ASD) students and students with related social-communication challenges (SCC) in Swedish primary school classrooms. In the current study half of the participating classrooms will receive the APERS-based model for program quality improvement, while the other half will receive services as usual. It is hypothesized that the APERS-based model will improve primary school program quality for children with ASD and SCC, … |
LISE ROLL-PETTERSSON; | 2022-08-15 |
| 361 | A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy and Safety of Pimavanserin for The Treatment of Irritability Associated With Autism Spectrum Sisorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 6-week, randomized, double-blind, fixed-dose, placebo-controlled, parallel group study in children and adolescents (aged 5 to17 years) with autism spectrum disorder (ASD) with irritability, agitation, or self-injurious behaviors to study the efficacy and safety of pimavanserin |
ACADIA PHARMACEUTICALS | 2022-08-09 |
| 362 | Development and Refinement of A Parent-mediated Mobile App Intervention for Parents of Children With Autism Spectrum Disorder Participating in An Adapted Horseback Riding Program Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this exploratory sequential mixed methods study is to develop and refine a parent-mediated mobile app intervention focused on improving the motor outcomes of children with autism spectrum disorder (ASD) participating in an adapted horseback riding program. |
LUIS COLUMNA; | 2022-08-08 |
| 363 | Active Ingredients & Efficacy of AquOTic: Aquatic Occupational Therapy for Children on The Autism Spectrum PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Accidental drowning is the number one cause of death in children with autism spectrum disorders (ASD) and highlights the critical need for swim lessons and water safety training for this population. Our team has developed and tested an innovative, occupational therapy (OT) based aquatic program – AquOTic – that provides preliminary support for the use of an individualized swim skills training intervention in children with ASD. The AquOTic program uses a combination of sensory, motor learning, and behavioral approaches to improve water safety and swim skills. In this study, … |
ERIKA KEMP; | 2022-08-04 |
| 364 | Analysis of Risk Factors of Neurodevelopmental Disorder in Deaf Infants Under Ten Months of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Among risk factors of neurodevelopmental disorder is congenital hearing loss. However, congenital deafness is neither necessary nor sufficient for the occurrence of warning signs of neurodevelopmental disorder. The investigative team hypothesizes that the co-occurrence of these two clinical entities results from a common origin, within a syndromic diagnosis including other medical issues. These situations would therefore be very different from those of babies suffering from isolated sensorineural deafness. This study aims to identify which factors are statistically correlated with the association of congenital deafness and early symptoms of neurodevelopmental disorder, … |
SALOMÉ AKRICH; | 2022-08-03 |
| 365 | Effect of PLAY Project Intervention Program on Children With Autism Spectrum Disorder: A Multi-center, Randomized Control Study in China PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the effectiveness of the Play and Language for Autistic Youngsters (PLAY) Project Home Consultation model to improve parent-child interaction, child development, and autism symptomatology in young children with autism spectrum disorders (ASDs) in China. |
YAN HAO; | 2022-08-01 |
| 366 | Ultrasound-Guided Single Shoot Serratus Anterior Plane Block Versus Erector Spinae Plane Block As Novel Techniques for Post-Thoracotomy Pain Control in Pediatric Cardiac Surgery and Its Effect in Ultra-Fast Track Recovery: A Prospective Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Objectives: Opioid based analgesia is the main used technique in pediatric cardiac surgery which preclude fast-track recovery. Ultrasound guided regional fascial plane blocks are used recently in many pediatric surgical procedure with excellent outcomes and very low rate of complication. The investigators will compare ultrasound guided serratus anterior plane block and erector spinae plane block in pediatric cardiac surgical procedure through thoracotomy approach regarding effectiveness of postoperative analgesia, … |
AIN SHAMS UNIVERSITY | 2022-07-24 |
| 367 | Outcomes and Neural Mechanisms of Emotion Regulation Therapy in Young Adults With Autism: A Pilot Feasibility Study Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot study is designed to investigate the clinical outcomes and neural mechanisms of emotion regulation behavioral treatment , in a small sample of young adults diagnosed with autism spectrum disorder. |
MICHAL ASSAF; | 2022-07-15 |
| 368 | Transcutaneous Electrical Acupoint Stimulation (TEAS) and Dense Cranial Electroacupuncture Stimulation (DCEAS) for Psychiatric Sequelae and Related Biomarkers in Women Victims of Domestic Violence: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an assessor-blinded, randomized controlled trial. A total of 110 women victims of domestic violence aged 18-65 years will be recruited from local community centers and domestic violence shelters (refugee centers). They will be randomly assigned to routine care combined with (n = 55) and without (n = 55) additional acupuncture (TEAS+DCEAS) for 12 weeks. Acupuncture therapy will be conducted with 2 DCEAS sessions at clinics and 3 TEAS sessions at home each week. The primary outcome is the Beck Depression Inventory II (BDI-II) for depression. Secondary outcomes include the 17-item Hamilton Depression Rating Scale (HAMD-17) for depression, … |
ZHANG ZHANG-JIN; | 2022-07-13 |
| 369 | Efficacy and Mechanism of Repeated Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorder: An Open-label Clinical Trial(Ⅱ) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a open-label clinical trial involving over 30 children aged ≥4 years with autism spectrum disorder. During the study, subjects received repeated transcranial magnetic stimulation (rTMS) intervention at the left primary motor cortex (M1) 10 times per day for 5 days. From the beginning of intervention to the end of 4 weeks after the completion of intervention, the subjects’s clinical symptomatology, cognitive psychology, neuroimaging, and adverse events will be followed up. Based on results from a recent unpublished pilot data, the investigators propose that cTBS treatment will induce a significant improvement in verbal/social communication performance in ASD children. |
FEI LI; | 2022-07-12 |
| 370 | Amplifying Treatment Response in Early Intervention ‘Minimal Responders’ With Autism Spectrum Disorder: A Virtual Parent-Coaching Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Early intervention (EI) using naturalistic behavioural methods have shown benefits for the development of communication and other skills for young children with autism spectrum disorder. The publicly funded autism EI program in Nova Scotia (NS) is based on such a method, Pivotal Response Treatment (PRT), and pre-post studies indicate benefits for children and families. However, not all children benefit equally. In this study, the investigators test the efficacy of a brief parent-mediated intervention designed to prime responsivity to PRT in children with a minimal responder profile derived from previous studies of the PRT-based EI program. |
ISABEL SMITH; | 2022-07-12 |
| 371 | An 8-Week, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Phase 3 Study of The Efficacy and Safety of Cariprazine in The Treatment of Pediatric Subjects (5 to 17 Years of Age) With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) consists of deficits in social, communication, and cognitive development, repetitive and stereotypic behaviors. Many ASD patients show notably high levels of irritability, including verbal and physical aggression, self injury, … |
ABBVIE | 2022-07-07 |
| 372 | The Relationship Between Parents’ Fatigue and Quality of Life, and The Quality of Life and Participation of Children With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: By comparing them to a healthy control group, this study aims to investigate the relationship between the participation of children with autism spectrum disorder (ASD) in home, school, and community environments and their parents’ fatigue, depression, and quality of life, … |
OZGUN KAYA KARA; | 2022-07-01 |
| 373 | Testing A Family Service Navigator Program for Low-resourced Families of Young Children with Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop and test a family navigator training and an app (a technology-based treatment support system) for low-resourced families of young children (aged 3-5) with autism. The hypothesis is that the navigator training and treatment support system will help enable navigators to support families of young children with autism in accessing needed services. |
MEGHAN BURKE; | 2022-07-01 |
| 374 | A Phase III Double-Blind, Randomized, Placebo Controlled, Multi Center Clinical Study to Evaluate The Efficacy and Safety of Intravenous L-Citrulline for The Prevention of Clinical Sequelae of Acute Lung Injury Induced By Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, placebo controlled, multicenter study to compare the efficacy and safety of L-citrulline versus placebo in patients undergoing surgery for congenital heart defects. Eligible patients undergoing repair of a large unrestrictive ventricular septal defect (VSD), a partial or complete atrioventricular septal defect (AVSD), or an ostium primum atrial septal defect (primum ASD) will be eligible for enrollment. |
CHRISTOPHER MASTROPIETRO; | 2022-06-29 |
| 375 | Parent-mediated Intervention for Toddlers With Early Social Communication Challenges or Emerging Autism: A Multi-site Randomized Controlled Trial of A Group-based Virtual Program That Empowers Parents As Change Agents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized control trial is to test the efficacy of the Social ABCs 6 week, group-based model using a virtual delivery platform. The Social ABCs is a caregiver-mediated early intervention program, aiming to increase child skills in directed, intentional vocalizations, and shared smiling with a primary caregiver for toddlers identified as early signs or a confirmed diagnosis of autism spectrum disorder (ASD), or having related social communication challenges. A positive RCT was previously completed using the program’s in-person individual, 12-week model, … |
JESSICA BRIAN; | 2022-06-27 |
| 376 | The Effect of Hepatic Impairment on The Pharmacokinetics of Balovaptan: A Phase I, Multiple-Center, Open-Label Study Following Multiple Daily Oral Doses of Balovaptan in Subjects With Moderate Hepatic Impairment and Healthy Subjects With Normal Hepatic Function Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, non-randomized, open-label, parallel group, multiple-dose study to assess the pharmacokinetic, safety, and tolerability of balovaptan in male and female subjects with moderate hepatic impairment compared to healthy subjects with normal hepatic function matched by age (±10 years), sex, and body mass index (BMI; ±20%). |
HOFFMANN LA ROCHE | 2022-06-26 |
| 377 | A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Single Dose, 2-Way, 2-Period Crossover Safety and Exploratory Efficacy Study of INP105 (POD-OLZ) for The Acute Treatment of Agitation in Adolescents and Young Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2a, proof-of concept, 2-way, 2-period crossover, double-blind study to evaluate the safety and efficacy of INP105 as an acute treatment versus placebo in adolescents and young adults with autism spectrum disorder (ASD) experiencing agitation. Approximately 32 ASD patients who are currently being treated for agitation/aggression at several inpatient units specializing in behavioral treatment will be enrolled. INP105 is a novel combination product that sprays a powder formulation of olanzapine to the upper nasal space. An earlier formulation showed a similar extent, but faster rate of absorption compared to the approved intramuscular product. In this study, … |
CRAIG ERICKSON; | 2022-06-23 |
| 378 | The Effects of Orally Administered Oxytocin on Behavioral and Neural Responses to Self Versus Other Touch Distinction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the study is to investigate the modulatory effects of oxytocin (24IU) administered orally using medicated lollipops on the behavioral and neural responses to touching yourself compared with being touched by others. |
KEITH KENDRICK; | 2022-06-22 |
| 379 | Contextual Behavioral Strategies to Help Parents Adhere to Behavior Plans for Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many children with autism demonstrate severe problem behavior (SPB) in the form of self-injury, aggression, and disruptive behavior. Conducting a functional analysis and implementing derived treatments can produce effective behavior plans. Nonetheless, skills training and an effective plan may not be sufficient to produce parent adherence. This applied research proposal describes an approach to target the negative maintaining contingencies supporting parent reinforcement of problem behavior (accommodation) and nonadherence. The intervention, borrowed from Acceptance and Commitment Therapy and Behavioral Activation strategies, … |
HUGO W MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER | 2022-06-21 |
| 380 | Maternal Risk Factors for Autism Spectrum Disorders: A Case-Control Approach PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: New research suggests that about 1 in 8 children may be diagnosed with an autism spectrum disorder (ASD) in the United States. This could be due to several reasons which remain unknown. This study invites mothers who have given birth to children in the United States to share their experiences with diet and supplementation during pregnancy. The purpose of this study is to understand the role of a mother’s diet, social standing, … |
MICHAEL HANIFF; | 2022-06-16 |
| 381 | Early Diagnostic Response Model (EDRM): Evaluating An Early Screening to Evaluation Pilot Protocol for Children Identified As High Risk for Autism in 3 Pilot Early Intervention Health Districts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Three districts of Babies Can’t Wait (BCW) will be referring families with children seeking an autism spectrum disorder (autism) diagnosis at the Emory Autism Center’s (EAC) Child Screening and Assessment Clinic.The objective of this study is to develop, pilot, and evaluate a diagnostic protocol for children identified at high risk for autism in the BCW early intervention program screening (part of a public health service). This program evaluation will be using pre- and post-data and data collected through the process to evaluate the effectiveness of the EDRM pilot. |
ALLISON SCHWARTZ; | 2022-06-16 |
| 382 | Medico-economic Evaluation of The Care By Serious Games in Outpatient Units and at Home for Children With Autism Spectrum Disorders PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized open-label study comparing children aged 3 to 6 years with autism and normal cognitive development or mild cognitive impairment receiving the usual treatment plus intensive use of eGOLIAH (experimental group) with children receiving only the usual treatment (control group). eGOLIAH (Gaming Open Library for Intervention in Autism at Home) is an accessible online platform for digital games inspired by the principles of the Early Start Denver Model (ESDM), … |
DOCTOR SUZANNE THÜMMLER; | 2022-06-15 |
| 383 | Effects of Exergaming on Bimanual Hand Dexterity in Autistic Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Through this study we aim to determine the effect of Exergaming on bimanual hand dexterity in Autistic children. This randomized controlled trial will recruit a sample of 20 autistic children as per the inclusion and exclusion criteria, through convenient sampling. The sample will be then randomly allocated to control group receiving the conventional dexterity training exercises and Intervention group which will be receiving conventional plus exergaming intervention. |
SARA AABROO; | 2022-06-15 |
| 384 | Testing The Feasibility of A Teletherapy Plus Parent Coaching Intervention for Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is one of the most frequently occurring childhood-onset neurodevelopmental disorders affecting 1 in every 54 children. Most children with ASD experience challenges participating in daily activities (e.g.: eating, sleeping, bathing, grooming, playing, etc.) and receive occupational therapy intervention to address these. The COVID-19 pandemic has restricted in-person therapy for many of these children and there is an urgent need for evidence-based, validated telehealth intervention. This project will adapt an evidence-based occupational therapy intervention, … |
THOMAS JEFFERSON UNIVERSITY | 2022-06-15 |
| 385 | The Listening Program With Bone Conduction Headphones Changes Hypersensitivity to Sound and Behavioral Responses Associated With Flight/Fight Responses of Children With Autism Spectrum Disorder Therefore Increasing Adaptive Life Skills Related Papers Related Patents Related Grants Related Experts View Highlight: There are limited approaches to specifically address auditory sensory over- and under-responsivity (SOR) in children with Autism Spectrum Disorder (ASD). Exposure therapy (or systematic desensitization) may be a treatment option; researchers are investigating this approach. Many children receive sensory integration therapy, but this approach does not specifically target auditory SOR. Some families are advised to have their children avoid noxious stimuli or use compensatory techniques such as wearing headphones or ear plugs. While preliminary research suggests that use of noise attenuating headphones may reduce sympathetic activation for children with ASD and auditory SOR, … |
SUZANNE VERCONTAIRE; | 2022-06-13 |
| 386 | The Effect of Simulation-based Training on Confidence and Competence in Obtaining Vitals in A Child With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective is to evaluate the efficacy of an online learning module combined with high fidelity simulation-based training in improving medical assistants’ and registered nurses’ self-confidence and competence scores in taking vital signs in a child with Autism Spectrum Disorder in clinic. The study will explore the efficacy of high-fidelity simulation which has not been studied to date as a training modality for teaching healthcare workers about Autism Spectrum Disorder. The investigators will also evaluate patient encounter data to provide insight into trainees’ transformation of knowledge into clinical practice. The hypothesis is that nurses and medical assistants who participate in an online learning module combined with simulation-based training will demonstrate improved self-confidence and competence scores in evaluating children with Autism. |
KEVIN CHING; | 2022-06-07 |
| 387 | Effectiveness of Home Based Early Intervention of Extremely Premature Infant By Parent PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to prove the effectiveness of home based early intervention of extremely premature infant by Parent. |
JEONG YI KWON; | 2022-06-02 |
| 388 | The Effect of Inspiratory Muscle Training on Respiratory Function, Balance and Functional Capacity in Trainable Mentally Handicapped Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The aim of this study was to examine the effect of inspiratory muscle training on respiratory functions, balance and functional capacity in trainable mentally disabled individuals. Methods: Within the scope of the study, 30 children, aged between 8 and 17 years, diagnosed with educable mental disabilities, were randomly divided into experimental and conventional physiotherapy rehabilitation program (CPRP) groups. Before and after the test, blood pressure, respiratory frequency, pulse oximetry heart rate and arterial oxygen saturation (SpO2) values, and Modified Borg scores for fatigue and dyspnea detection were recorded. Body composition analysis, respiratory function test, … |
HANIFE ABAKAY; | 2022-06-02 |
| 389 | Can A Novel Telemedicine Tool Reduce Disparities Related to The Identification of Preschool PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Families seeking evaluation for autism spectrum disorder (ASD) often face barriers such as low availability of specialists, lengthy waitlists, and long distances to tertiary care diagnostic centers. This is especially true for children from traditionally underserved groups and communities. Without innovative approaches for enhanced identification of ASD, families and clinicians will continue to struggle with accessing and providing care. Telemedicine offers tremendous potential for addressing this need, but there are few psychometrically sound, validated tools that can be administered remotely, via telehealth platforms. This team of investigators developed and conducted a preliminary evaluation of a novel parent-administered, clinician-guided tele-diagnostic tool, … |
ZACHARY WARREN; | 2022-06-01 |
| 390 | The Effect of Cognitive Behavioral Therapy on Psychological Distress Among Mothers of Children With Autism Spectrum Disorders: The Role of Problem-Solving Appraisal PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cognitive behavioral therapy sessions can effectively reduce distress in mothers of children with autism. here we emphasize on the role of problem solving appraisal in CBT sessions to improve problem solving skills ability and minimize psychological distress . pre- intervention assessment (T1) for all participants , then designed 8 sessions for study group will apply . post intervention assessment (T2) will conduct immediately after CBT sessions |
ENAS MAHROUS ABDELAZIZ; | 2022-06-01 |
| 391 | Evaluating The Behavioral Effect of A Virtual Reality-mediated Mindfulness-based Interventions on Parents of Children With Autism: A Randomized Controlled Trial (RCT) Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mindfulness is a technique that involves the intentional and non-judgmental regulation of attention to the present moment, with curiosity, openness, and acceptance, as per its definition. Mindfulness-based interventions (MBIs) have been used to manage mood disorders in various clinical and non-clinical settings, including neurological patients and cardiovascular diseases. Studies have consistently demonstrated that MBIs reduce depressive and anxiety symptoms, … |
ANTONIO CERASA; | 2022-06-01 |
| 392 | Clinical Trial of Fecal Microbiota Transplantation in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. Intestinal microbial disturbance is common in children with ASD, and about 40% of ASD children suffer from gastrointestinal dysfunction. A great deal of evidence shows that intestinal microbes can influence the brain to play its role through brain-intestinal-microbiota axis. Fecal microbial biota transplantation (FMT) is the most direct way to change the intestinal flora rapidly. We intend to study the difference of intestinal flora structure and metabolism between ASD children and control children at the level of phylum, genus and species; … |
YAN HAO; | 2022-06-01 |
| 393 | Evaluating The Efficacy of Transcranial Pulse Stimulation (TPS) on Individuals with Autism Spectrum Disorder (ASD)- A Double-blinded, Randomized, Sham-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the efficacy and tolerability of TPS on young adolescents with ASD. Methods: This is a two-armed, randomized, double-blinded, sham-controlled trial. Sampling: A total number of 36 subjects, aged between 12 to 17, diagnosed with ASD, will be recruited. Individuals with a Childhood of Autism Rating Scale (CARS) score ≤ 30 (i.e., … |
TERIS CHEUNG; | 2022-06-01 |
| 394 | Development and Validation of A System for The Anticipation of Challenging Behaviors of People With Autism Spectrum Disorder Based on A Smart Shirt: A Mixed-method Design PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Most people with autism spectrum disorder (ASD) present at least one form of challenging behavior (CB). Self-injurious, aggressive, and disruptive CBs linked with social interaction, community-based service exclusion, and a life quality reduction for people with ASD, their caregivers, and health professionals. The current study has three objectives: 1) to assess the differences in the physiological reaction of high-functioning adults with ASD and typically developed peers, using bio-signal measurements such as heart rate derived from wearable Smart Shirt (SS), 2) to learn which physiological parameters can best predict the imminent onset of a CB, … |
MEIR LOTAN; | 2022-06-01 |
| 395 | Modulation of Neurocognitive Mechanisms Involved in Inhibitory Control in Tic Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study aims to assess the effects of non invasive electrical stimulation of the vagus nerve via transcutaneous vagus nerve stimulation (tVNS) on cognitive functions, inhibitory and tic control in patients with tic disorders. Taking into account the role that GABA plays in inhibitory control, the presence of alteration of GABA neurotransmission in Tic disorders and the possibility to increase GABA release with tVNS, the investigators hypothesized that tVNS might improve behavioral control in Tic disorders. Moreover, as suggested by previous studies investigating the effects of tVNS in other patient populations, … |
IRCCS EUGENIO MEDEA | 2022-06-01 |
| 396 | Evaluating The Effect of Immersive Room Intervention on Visual Attention in Children With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by language delay, impaired social interactions, and repetitive behaviors. Its manifestation varies among individuals due to genetic and environmental factors. Technology-based interventions, such as robots, serious games, virtual reality and immersive room, have shown better results in the cognitive-behavioral treatment of ASD. Visual attention, which is often deficient in individuals with ASD, is a focus in these interventions, as it can aid stimulus processing. Virtual reality offers a more ecological environment for such interventions. In this study, … |
FLAVIA MARINO; | 2022-06-01 |
| 397 | Holter and ECG Changes After Transcatheter Closure Of ASD In Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Atrial septal defects (ASD) account for 10% of all congenital heart defects [1]. Hemodynamic consequences of an ASD are dilatation of the right atrium and right ventricle (RV) because of the volume overload due to the left-to-right shunt through the ASD.For several decades, surgical closure has been considered the standard method of repairing a secundum ASD [2]. Surgical repair, albeit enjoying a high success rate, negligible mortality, and good long-term outcome, is associated with morbidity, discomfort, … |
MARWA AHMED ABDEL GALIL; | 2022-06-01 |
| 398 | Modulation of The Activity in The Cerebellum With Transcranial Direct Current Stimulation in Autistic Participants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Research on the involvement of the cerebellum in social understanding behavior and the mentalizing brain system has just begun. Knowledge about the neurobiology of social understanding is important for understanding the ways to manipulate these processes. Like cerebral tDCS, cerebellar tDCS could then be used to enhance more complex processes, such as mentalizing, in healthy individuals. It can eventually also be examined as a therapeutic tool for patients with mentalizing difficulties such as patients with ASD. In this study, … |
BEATRIZ CATOIRA; | 2022-05-24 |
| 399 | The Effect of A Combination of Human Milk Oligosaccharides (HMOs) and Probiotics on Behavioural Change in Children With Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research project will investigate if a supplement containing a unique combination of prebiotics and probiotics can influence behaviour in children diagnosed with autism spectrum disorder. The study will use a combination of human milk oligosaccharides (HMOs, prebiotics) and probiotics as an oral powder.This clinical trial will have two consecutive phases. Phase 1A is an 8-week randomised, double-blinded, placebo-controlled trial. Participants will be recruited and randomised (1:1) to receive either the investigational product (treatment group, n=30) or the placebo (control group, … |
PETER SW DAVIES; | 2022-05-17 |
| 400 | Improving Outcomes in Autism: Community Implementation of Stepped Transition in Education Program PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to conduct the first community-based implementation of the STEPS program and test feasibility and preliminary impact. After first working with stakeholders to refine and optimize the program we will launch a Hybrid Type 1 open trial, targeting 25 transition-age youth (TAY) with ASD. |
SUSAN W WHITE; | 2022-05-15 |
| 401 | Feasibility Study About Super Digital Platform: A Joint System for Rehabilitation and Educational Projects for Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Due to its complexity and variability, Autism Spectrum Disorder (ASD) requires multidisciplinary and multidimensional interventions. SUPER (in Italian: Sistema Unitario in una Piattaforma Riabilitativa ed Educativa) is an Italian digital platform, implemented to facilitate collaboration between families, health services, and schools and to promote personalized intervention for children with ASD. The research protocol, aimed to test SUPER’s feasibility and usability, foresees the enrollment of 12 ASD children in the Experimental Group (EG) and 12 ASD children for the Control Group. All families, teachers, and clinicians will perform usual rehabilitative and educative interventions, but the EG will use SUPER, … |
GIULIA PURPURA; | 2022-05-09 |
| 402 | Transcranial Photobiomodulation for Reducing Autism Symptoms in Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The hypothesis of the study is that photobiomodulation reduces symptoms of autism. Participants will be children between the ages of 2 and 7, who have been diagnosed with moderate to severe autism. Transcranial photobiomodulation will be administered to the children in the experimental condition twice a week for 10 weeks. Results will be measured through parental interviews, standardized CARS2 (Childhood Autism Rating Scales, 2nd Edition) and data collected from EEG. |
YULI FRADKIN; | 2022-05-08 |
| 403 | Effects of A Motor Intervention Program on Motor Skills and Adaptive Functions for Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be a randomized controlled trial, which will aim to establish the appropriate and feasible content of the planned motor intervention program. A sample of 30 young children with ASD (4 to 5 years old) will be randomly assigned to treatment and control groups. Children in the treatment group will receive a 8-week motor skill intervention program. Children in the control group will receive a 8-week cognitive training program. Each week will be of 1.5-hour duration. Outcome measurements will consist of the Bruininks-Oseretsky Test of Motor Proficiency-Second Edition Brief Form and Vineland Adaptive Behavior Scales-Third Edition. A two-factor mixed design ANOVA will be conducted to compare pre- and post-tests differences in the treatment and control groups. The findings of the proposed study will be useful for occupational therapists and clinicians to assist caregivers in implementing the intervention program and will contribute to knowledge regarding the effects of motor intervention program on increasing the motor skills of young children with ASD in Taiwan. Practitioners can design a standard treatment manual and provide information for implementing the motor intervention program. The expected results will help clinicians apply empirical knowledge to provide and promote the health and development of young children with ASD. |
LING-YI LIN; | 2022-05-06 |
| 404 | Refining and Implementing Technology-Enhanced Family Navigation to Promote Early Access and Engagement With Mental Health Services for Youth With Autism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project, Refining and Implementing Technology-Enhanced Family Navigation to Promote Early Access and Engagement with Mental Health Services for Youth with Autism (ATTAIN NAV) is focused on adapting and implementing family navigation in primary care settings to help accelerate and facilitate engagement in mental health and community services for children with autism and their families. |
NICOLE STADNICK; | 2022-05-01 |
| 405 | Transcutaneous Auricular Vagus Nerve Stimulation Improves Inhibitory Control in Emotional Go-Nogo Task PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) improves the ability of inhibitory control in an emotional Go-Nogo task. |
KEITH KENDRICK; | 2022-05-01 |
| 406 | The Effect of Animal-Assisted Therapy on Prosocial Behavior in Children With Developmental Delay or Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to evaluate the effect of animal-assisted therapy (AAT) on prosocial behavior and emotional regulation in children with developmental delay, behavioral concerns, or autism spectrum disorder. Service dog use in the pediatric population who have these concerns is increasing and more studies are indicated to determine best practice for incorporating canines into traditional therapy sessions to enhance therapeutic outcomes. The hypothesis for this study is that inclusion of the canine will enhance therapy sessions and produce a lasting effect on prosocial behavior and emotional regulation after AAT sessions have concluded. |
MICHELE KILMER; | 2022-05-01 |
| 407 | Intermittent Theta-Burst Stimulation to Target Irritability in Adults With ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to demonstrate the feasibility, tolerability, safety and preliminary efficacy of 6 weeks of fMRI-guided iTBS delivered to personalized regions of the prefrontal cortex (PFC) in adults with ASD in reducing irritability in adults with ASD. |
LAWRENCE FUNG; | 2022-05-01 |
| 408 | A Randomized Study to Compare The Efficacy of Primary Thrombectomy With Double Stent (DS-EVT) Versus Primary Thrombectomy With One Stent (SS-EVT) As An Initial Attempt at Thrombectomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The use of a double stent retriever (Dual-SR) has been proposed as a safe and effective technique. The invesigators hypothesized that the use of Dual-SR primary could lead to higher first-pass effect rates and better outcomes compared to Single-SR primary. Our goal is to develop a research project to provide additional information on the potential benefits of the simultaneous double stent approach primarily in stroke patients receiving TVS. A randomized study to compare the efficacy of double primary SR versus single primary SR |
HOSPITAL UNIVERSITARI VALL D’HEBRON RESEARCH INSTITUTE | 2022-04-21 |
| 409 | Characterizing Occupational Therapy Intervention for Children With Autism Spectrum PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot study aims to identify behavioral and neural measures of sensory processing and attention associated with routine occupational therapy intervention for children with autism spectrum disorders. Specifically, the investigator will examine the impact of a child’s level of engagement during therapy using standardized behavioral and electroencephalography (EEG) measures of sensory processing. |
JEWEL CRASTA; | 2022-04-19 |
| 410 | Investigation of The Effect of Yoga on Balance, Reaction Time and Agility in Children With Attention Deficit and Hyperactivity Disorder: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose: To determine the effect of 8-week kids yoga training on balance, reaction time and agility on children diagnosed with attention deficit hyperactivity disorder (ADHD). Method: A randomized controlled trial. The intervention (kids yoga) was an 8-week program administered to children attending a special education center by a yoga instructor occupational therapist. Outcomes included Pediatric Balance Scale, Bruininks-Oseretsky Motor Proficiency Test-Short Form, and Microgate Witty SEM System assessed at baseline and at the end of 8th week. |
CEMRE BAFRALI; | 2022-04-15 |
| 411 | Social Anxiety MDMA-Assisted Therapy Investigation (SAMATI): A Randomized, Delayed Treatment Control Phase 2 Study of The Safety and Effectiveness of Manualized MDMA-Assisted Therapy for The Treatment of Social Anxiety Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, open-label delayed treatment study to assess the safety and effect of MDMA-assisted therapy in treating 20 participants diagnosed with moderate-to-severe social anxiety disorder (SAD) of the generalized subtype. This study will obtain an estimate of effect size for two experimental sessions of MDMA-assisted therapy for the treatment of social anxiety disorder on measures of safety, social anxiety, functional outcomes, psychiatric symptoms, and putative mechanisms of action. The primary outcome for this study will be the Liebowitz Social Anxiety Scale (LSAS) administered by a blinded Independent Rater (IR). Other assessments, including physiological, self-report, … |
JASON B LUOMA; | 2022-04-13 |
| 412 | The Autism Biomarkers Consortium for Clinical Trials PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter longitudinal study that aims to validate a set of measures that were previously identified as promising candidate biomarkers and/or sensitive and reliable objective measures of social function in ASD for potential use in clinical trials. The confirmation study will repeat the data collection and analysis protocols from the original ABC-CT study. This confirmation study will recruit 200 ASD and 200 TD comparison participants who are 6-11 years old, matching the overall sample size but providing a larger normative reference sample and greater statistical power for group comparisons. |
JAMES C. MCPARTLAND; | 2022-04-11 |
| 413 | A Clinical Study Evaluating The Efficacy and Safety of Retinoic Acid in Patients With 15q11-q13 Duplication Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorders (ASD), with its core symptoms of communication and repetitive behaviors, is a serious neurodevelopmental disorder common in childhood and affects about 1% of children. So far, autism remains a clinical dilemma with no effective therapy. The most common chromsomal ability among ASD patients is 15q11-13q duplication syndrome(dup15q syndrome).Clinical phenotypes of dup15q syndrome include autism, mental retardation, epilepsy (usually refractory epilepsy, often manifested as infantile spasm), congenital heart disease, mild facial abnormalities, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2022-04-01 |
| 414 | Efficacy of Administering Oxytocin Orally Using A Medicated Lollipop Approach on Peripheral Concentrations and Attention: Comparisons With Intranasal and Lingual Spray Administration PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will investigate whether oxytocin (24IU) administered orally using medicated lollipops results in increased peripheral oxytocin concentrations and can modulate social attention in an anti-saccade paradigm in the same way as when it is administered by intranasal or lingual routes. |
KEITH KENDRICK; | 2022-04-01 |
| 415 | Holter and ECG Changes After Trancatheter Closure Of ASD In Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Atrial septal defects (ASD) account for 10% of all congenital heart defects . Hemodynamic consequences of an ASD are dilatation of the right atrium and right ventricle (RV) because of the volume overload due to the left-to-right shunt through the ASD.For several decades, surgical closure has been considered the standard method of repairing a secundum ASD . Surgical repair, albeit enjoying a high success rate, negligible mortality, and good long-term outcome, is associated with morbidity, discomfort, … |
MARWA AHMED ABDELGALIL; | 2022-04-01 |
| 416 | Improving Transition Outcomes for Youth With Autism Spectrum Disorder From Within A Medicaid Accountable Care Organization Related Papers Related Patents Related Grants Related Experts View Highlight: Despite an increasing number of children with Autism Spectrum Disorder (ASD), fragmentation across child and adult service systems results in poor education, employment and health outcomes for transition-aged youth (TAY). The investigators will develop a transition intervention embedded in a series of systems-level strategies currently being deployed in a large Medicaid Accountable Care Organization (ACO). The investigators will conduct a randomized pilot study of 40 families of TAY with ASD. All families will receive care by providers trained in the Got Transition toolkit (the systems level component of the intervention) and have access to web-based transition resources. Families in the ‘intervention refinement’ arm will also receive a family-based problem solving education (PSE) intervention. |
MICHAEL SILVERSTEIN; | 2022-04-01 |
| 417 | FOOD-AUT Pilot Study Developing Canteen Menus Targeted to Nutritional and Sensory Needs of Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The FOOD-AUT pilot study aimed to improve the health status of adults with Autism Spectrum Disorder (ASD) through a nutritional intervention at canteen service. The researchers adapted the canteen menus to the nutritional and sensory needs of this vulnerable population, reducing their food selectivity and improving their dietary diversity with a positive impact on their health. This project consisted of two phases: first an observational phase (Work Package 1, WP1) and secondarily an interventional phase (Work Package 2, WP2). |
HELLAS CENA; | 2022-03-30 |
| 418 | Internet-Based, Parent-Led Cognitive-Behavioral Therapy for Anxiety in Youth With ASD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares the effectiveness of two levels of therapist support for an internet-based, parent-led cognitive behavioral therapy for youth with anxiety and ASD. |
ANDREW GUZICK; | 2022-03-28 |
| 419 | The Impact of A Parent-mediated Intervention on Social Behaviour and Social Brain Development in Infants at High Risk for Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomised-controlled trial will assess the effect of an early intervention on the social-communicative abilities and brain activity of infants with elevated likelihood of Autism Spectrum Disorder (ASD). The children´s social-communicative abilities and the related brain activity will be evaluated at three time points: before the start of the intervention (pre-intervention), immediately after its conclusion (post-intervention) and 6 months after its conclusion (follow-up). |
HERBERT ROEYERS; | 2022-03-28 |
| 420 | Phase I Pre-pilot Open-label Clinical Trial of Nabilone for Severe Behavioural Problems (aggression) in Adults with Intellectual and Developmental Disabilities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Innovative treatments are urgently needed for severe behavioural problems (SBPs) in adults with intellectual and developmental disabilities (IDD). Although a synthetic cannabinoid, nabilone may be a plausible and safe alternative to treat SBP, safety and efficacy of nabilone in people with IDD has never been evaluated. The investigators propose to conduct this first-ever Phase I pre-pilot open-label clinical trial to collect data on the tolerability and safety profile of nabilone in adults with IDD, and explore changes in SBP pre- and post-treatment. The results will inform a next-stage pilot randomized controlled trial, followed by a fully powered trial eventually. |
HSIANG-YUAN LIN; | 2022-03-17 |
| 421 | Noninvasive Brain Stimulation to Treat Core Social Deficits in Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized interventional study designed to evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in adults with autism spectrum disorder (ASD). |
JAMES MCPARTLAND; | 2022-03-17 |
| 422 | Validation of A Salivary MiRNA Diagnostic Test for Autism Spectrum Disorder PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months. Participants will at each timepoint have a non-invasive saliva swab collected and complete a brief demographic and medical history questionnaire as well. Children in the pediatric/provider setting who will receive a referral for an ASD diagnosis because they were determined to have a suspicion of developing ASD will be enrolled in the study. Children will also be enrolled in the specialist evaluation setting where they will receive a DSM-5 diagnosis. A subset of both enrollment cohorts will also be followed up with at a third time point in which their diagnosis will be confirmed, and information about any ongoing treatment will be gathered. |
DAVID LEVITSKIY; | 2022-03-16 |
| 423 | Study of The Prevalence of Autistic Traits in Angelman Syndrome, The Correlation With Cognitive Level, Epilepsy, With Socio-communication Skills and Parenting Styles PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational cross-sectional study is to establish the prevalence of autism spectrum disorder in children and adolescents with Angelman syndrome. The main questions it aims to answer are: – which clinical variables differentiate AS patients with and without Autism Spectrum Disorder between genetics, epilepsy, pharmacotherapy, behavioural problems, parenting style and parents’ perceived stress. – which clinical variables differentiate parenting styles and levels of perceived stress. We collect data from neuropsychological, speech therapy and physiotherapeutic assessments, during regular clinical follow-ups, regarding: cognitive development (Bayely Scales of Infant Development-III, Cognitive Scale) and adaptive behaviour; … |
MARTINA BAGGIO; | 2022-03-15 |
| 424 | Enhancement of Behavioral and Cognitive Outcomes in Autism Spectrum Disorder Via Neurostimulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) encompasses a range of limitations in reciprocal social and communicative milestones, as well as restrictive and/or repetitive patterns of behavior which lead to significant functional challenges impacting individuals throughout their lifespan. There are major shortcomings in the existing pharmacological interventions; they are of limited efficacy, target a subset of problematic behaviors, and fail to improve social cognition. To overcome these limitations and improve outcomes, the investigators study the use of neurostimulation to mitigate the social and cognitive manifestations of ASD. |
MITRA ASSADI; | 2022-03-15 |
| 425 | Magnetic Resonance Imaging Neuroanatomical Study of Patients with An Autism Spectrum Disorder, Their Relatives and Typically Developing Subjects PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This project is structured around a central study called Study of genetic factors involved in autism and related conditions (Genes and Autism study, sponsor: INSERM). This study explores clinical and genetic aspects of ASD (autism spectrum disorders) and is complemented with several ancillary studies (such as this one) which will use the data of the main study and will allow an extensive review of phenotypes associated with ASD. In this ancillary study, we will go on the acquisition of anatomical, diffusion and functional MRI in subjects with ASD, … |
RICHARD DELORME; | 2022-03-13 |
| 426 | Effects of Parent-Mediated Intervention on Restricted and Repetitive Behaviors in Children With ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our primary aim in the study is to investigate the effect of an online group-based 8-week parent-mediated intervention program targeting social communication on restrictive repetitive behaviors. Our second aim is to investigate the factors affecting the change in restrictive repetitive behavior. Our hypotheses are that after completing the 8-week online group-based parent-mediated intervention program, the participants’ social interaction skills will increase, their restrictive repetitive behaviors will decrease, and their emotion regulation problems will decrease. |
SABRI HERGÜNER; | 2022-03-12 |
| 427 | Allogeneic Wharton Jelly Mesenchymal Stromal Cell (WJMSC) for Treatment of Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. |
HANAN JAFAR; | 2022-03-09 |
| 428 | Use of Immersive Virtual Reality to Train The Multisensory Processing Capacities of Children Aged 8 to 16 Years-old With An Autism Spectrum Disorder: Single-center Randomized Pilot Study in Parallel Groups – SEVIRE. (Sensory Virtual Reality) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is defined as a neurodevelopmental disorder that affects the functioning and development of social communication (DSM5 – 2013). ASD causes particularities in sensory treatments (auditory, visual), qualified as uni-modal. Added to this, there is difficulties to deal with prevailing stimuli of the environment (pluri-modal) ; parents report the discomfort of their child in this situation with noisy behavioral manifestations. Therapeutic social skills programs most often address the subject’s lack of adjustment to their environment through understanding social rules and codes and cognitive treatment of situations. Thus, … |
UNIVERSITY HOSPITAL TOURS | 2022-03-03 |
| 429 | Computer-Mediated Intervention to Enhance Emotional Competence in Children With Autism in Schools PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum condition (ASC) is a neurodevelopmental disorder characterized fundamentally by social deficits. Emotional competence – the ability to express, recognize, understand, and regulate emotions – is a key aspect of social communication. Evidence suggests that the developmental trajectories of autistic children differ from that of neuro-typical children regarding their ability to process and recognize emotions from paralinguistic emotional facial, body language, and voice tone cues. They also have difficulty integrating these cues in context and lack in emotional language. Numerous approaches to teaching people with autism how to recognize and understand emotions have been tried, … |
OFER GOLAN; | 2022-03-01 |
| 430 | Improvement In Left Ventricular Diameter After Closure Of Atrial Septal Defect With Fenestrated Patch: A Cross-sectional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: The presence of pulmonary hypertension (PH) in atrial septal defect (ASD) poses a clinical challenge on whether or not to close the defect. Closing the defect increases the risk of low cardiac output syndrome (LCOS), while leaving the defect open may eventually lead to irreparable shunt reversal, hypoxemia, … |
HEROE SOEBROTO; | 2022-03-01 |
| 431 | A Comparison Of The Effect Of Target-Controlled Infusion Anesthesia And Inhalation Anesthesia On Patient Outcomes In Pediatric Patients Undergoing Endovascular Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A total of 70 patients who underwent angiographic examination, ASD closure, VSD closure, PDA closure and aortic balloon dilatation were included in this study. |
SIBEL SEÇKIN PEHLIVAN; | 2022-03-01 |
| 432 | Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency): Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is currently no treatment for the body symptoms of Autism Spectrum Disorders (ASD). However, basic research suggests that some forms of ASD may be alleviated, even in the adult stage. The genes involved in ASDs particularly impact synaptic homeostasis. Specific clinical trials in patients with synaptic mutations need to be carried out. In this spirit, patients with deleterious mutations in SHANK3 represent a paradigm. The induced pluripotent stem cells (iPSc) carrying SHANK3 mutations and derived in neurons, … |
DELORME RICHARD; | 2022-02-21 |
| 433 | Evaluation of An Explicit Approach to Teach Grammatical Forms to Children With Language Impairment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized clinical trial that uses a Sequential Multiple Assignment Randomized Trial (SMART) study design. The study will directly compare the efficacy of an innovative intervention that combines explicit and implicit approaches to a traditional implicit treatment approach to teach true grammatical forms to children with developmental language disorder (DLD). The study will also compare interventions that include sequences of Explicit-added and Implicit-only treatments. Participants will include 5- through 9-year-old children with DLD who present with significant grammatical weaknesses. In Phase 1, … |
UNIVERSITY OF MINNESOTA | 2022-02-15 |
| 434 | Equine-assisted Therapy for Therapy-resistant Adolescents With Autism Spectrum Disorders, A Replicated AB-design PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the (cost)effectivity of Equine assisted Therapy in adolescents with Autism Spectrum disorders. |
NANDA LAMBREGT-ROMMELSE; | 2022-02-14 |
| 435 | THRIVE-ASD: Telehealth Rapid Intervention for Externalizing Behaviors in ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to evaluate a time-limited version of Parent Child Interaction Therapy (PCIT) delivered via telehealth for young children with autism spectrum disorder (ASD) and disruptive behavior problems. Families will be randomly assigned to receive 10 sessions of Tele-PCIT or Treatment as Usual. Families will complete a baseline assessment, a post-treatment assessment, and a 3-month follow-up. |
ROSMARY ROS-DEMARIZE; | 2022-02-11 |
| 436 | Evaluation of Transcranial Photobiomodulation in Autism Spectrum Disorder: Double-Blind, Placebo-Controlled, Randomized Clinical Study of A Novel Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this 8-week double-blind randomized placebo-controlled study is to assess the tolerability, safety, and efficacy of tPBM in adult patients with ASD. |
TOLGA A CERANOGLU; | 2022-02-11 |
| 437 | A Randomized, Placebo-Controlled Crossover Trial to Assess The Safety and Efficacy of NB-001 in Children and Adolescents With 22q11 Deletion Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2, randomized, placebo-controlled crossover trial to assess the safety and efficacy of NB-001 in children and adolescents with 22q11DS that manifest commonly associated neuropsychiatric conditions. |
NAOMI MEEKS; | 2022-02-10 |
| 438 | Effect of Deep Propioceptive Stimulation on Sleep Disorders, Behavior and Brain Connectivity in Adults with Prader-Willi Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective is to study the effect of deep propioceptive stimulation with a heavy blanket for 2 weeks compared with a placebo blanket on sleep quality and behavior in patients with PWS |
ASSUMPTA CAIXAS; | 2022-02-10 |
| 439 | Better Understand Motor Deficits Associated With Autism Spectrum Disorders: Development of An Assessment Protocol PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research is a case-control study aiming to characterize motor peculiarities (objective quantitative and qualitative measures) and its psycho-physiological correlates of children with ASD. |
HELENE COTTENCEAU; | 2022-02-07 |
| 440 | Biomarker-Driven Pharmacological Treatment for Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The social cognitive deficits associated with autism spectrum disorder (ASD) are related to an imbalance in excitatory and inhibitory neurotransmission, specifically a deficit in the inhibitory neurotransmitter GABA. The investigators have used magnetic resonance spectroscopy (MRS) techniques to measure GABA in specific brain regions and have demonstrated that a single dose of gabapentin increases GABA in brain regions associated with social cognition. This study will use a biomarker-driven approach to investigate gabapentin to correct the underlying imbalance of neurotransmitters and improve the core social cognitive deficits in ASD. By using a brain-based biomarker (GABA) that is quantifiable and measurable, … |
DAVID COCHRAN; | 2022-02-04 |
| 441 | Autism Spectrum Disorders: Double Blind Randomized Placebo-control Active Pilot Study of Transcranial Magnetic Stimulation Applied to The Superior Temporal Sulcus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Difficulties in social interactions are the core feature of autism spectrum disorder (ASD) and are characterized by abnormal social perception, mainly concerning eye gaze. Anatomo-functional abnormalities within the superior temporal sulcus (STS), a key region of the social brain, have been described in ASD. The investigators had recently shown that it is possible to modulate the neural activity of the STS with transcranial magnetic stimulation (TMS) with an impact on social perception, measured by eye-tracking. In the context of ASD, stimulation of the STS with excitatory TMS could lead to an improvement in social perception, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-02-02 |
| 442 | The Development of A Screening Questionnaire to Discriminate Autism Spectrum Disorder and Schizotypal Disorder, and Validation of The Danish Version of RAADS-R PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to investigate the validity, reliability and clinical features of a Danish version of the Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R). A self-reporting scale devise used as a supplementary questionnaire in diagnosing autism spectrum disorder (ASD) in adults. Furthermore the validity of novel screening questionnaire: SchiZotypal Autism Questionnaire (ZAQ), will be investigated. ZAQ is developed to discriminate Schizotypal Disorder from ASD. |
RIZWAN PARVAIZ; | 2022-02-01 |
| 443 | Combined PET and MR Investigations of The Pathophysiology of Gilles De La Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Gilles de la Tourette syndrome (GTS; also known as Tourette syndrome) is a congenital neuropsychiatric disorder. Characteristic symptoms are so-called tics-rapid, repetitive movements (motor tics) or vocalizations (vocal tics) that start suddenly without any apparent purpose. Previous research supports the hypothesis of defective regulation (dysregulation) of the dopaminergic system, with particular discussion of dysfunction of tonic/phasic dopamine release or dopaminergic hyperinnervation. Moreover, given the complex interaction of different neurotransmitters, especially in the basal ganglia, it can be assumed that abnormal dopaminergic transmission also affects other transmitter systems, such as glutamate (Glu) or γ-aminobutyrate (GABA). Furthermore, … |
HARALD E MÖLLER; | 2022-02-01 |
| 444 | Neural Basis of Social Cognition Deficits in Youth With Autism and Schizophrenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Difficulties in reciprocal social interaction are hallmark features of several neuropsychiatric disorders, most notably autism spectrum disorder (ASD) and schizophrenia spectrum disorder (SSD). While recent studies have demonstrated substantial overlap in genetic etiology between ASD and SSD, little is known about common versus unique neural mechanisms that may underlie these downstream social deficits that cross diagnostic boundaries. Thus, a comprehensive imaging study examining social deficits in youth with ASD and adolescent- onset SSD at the neurochemical, connectivity, as well as functional activation level will be crucial in furthering our understanding of these underlying neural mechanisms. Specifically, … |
AARTI NAIR; | 2022-02-01 |
| 445 | A Pilot Study of Transcranial Direct Current Stimulation (tDCS) in Children With Autism Spectrum Disorder Related Papers Related Patents Related Grants Related Experts View Highlight: Although many children diagnosed with autism spectrum disorder (ASD) make significant progress in learning and their cognitive skills improve with applied behavior analysis (ABA), there are a significant number of children who show an absence or a plateau in various skills. Deficits in executive functioning are likely to be involved in many of these cognitive and learning disabilities due to poor functioning of the prefrontal cortex. Currently, … |
BARBIE ZIMMERMAN-BIER; | 2022-02-01 |
| 446 | Extension for Community Healthcare Outcomes (ECHO) Autism Diagnostic Study in Primary Care Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a collaborative study that will provide a comprehensive source of observational data that can be used to obtain real world evidence of ASD. The study will contain demographic and observational clinical data for eligible participants. All decisions regarding patient care will be determined by the ECHO Autism Clinician (EAC). All clinical outcomes will be assessed by the EAC as would occur in routine clinical practice. |
COGNOA | 2022-01-31 |
| 447 | Smartphone Mindfulness Autism Research Team Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Individuals diagnosed with autism are also often diagnosed with anxiety disorders. Therefore, having useful strategies to manage stress and anxiety may be particularly helpful for autistic individuals. Mindfulness-based interventions, delivered in-person as well as those offered remotely online, have been found to lower stress and anxiety. Although in-person mindfulness training has been found to be helpful for autistic individuals, there is little research that has studied remote app-based mindfulness training in autistic adults. This study examines whether a six-week structured intervention, using a mindfulness app, … |
JOHN DE GABRIELI; | 2022-01-30 |
| 448 | Efficacy and Mechanism of Repeated Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorder: An Open-label Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a 6-week open-label clinical trial involving 20 children aged 6-10 years with autism spectrum disorder. During the study, subjects received repeated transcranial magnetic stimulation（rTMS）intervention at the left primary motor cortex (M1) 5 times per day for 10 days. From the beginning of intervention to the end of 4 weeks after the completion of intervention, the subjects’s clinical symptomatology, cognitive psychology, neuroimaging, and adverse events will be followed up.Our purpose is to explore whether rTMS can improve the clinical symptoms of children with autism spectrum disorder in China, … |
FEI LI; | 2022-01-28 |
| 449 | An Integrated Nutrition Intervention Through The Part C Early Intervention Services to Promote Healthy Eating Habits for Children With ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is an unmet need for nutrition interventions that address both autism spectrum disorder (ASD) specific feeding challenges and unbalanced eating habits among children with ASD to prevent future chronic health conditions. Children with ASD tend to consume few fruit and vegetables and mainly high-energy dense foods, including sugar-sweetened beverages and processed snacks. Obesity prevalence in children with ASD is up to 40% higher than in typically developing children, and recent studies show significantly elevated risks of hyperlipidemia and hypertension among individuals with ASD, … |
HEEWON L GRAY; | 2022-01-27 |
| 450 | Pediatric Early Autism Recognition System: PEARS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to assess a new autism evaluation model that would include the addition of a Level-2 autism screener, the Rapid Interactive Screening Test for Autism in Toddlers (RITA-T), to the developmental screening already done by the child’s pediatrician. The study hypotheses: 1. The PEARS intervention will show high feasibility to primary care physicians (PCPs) and patient families. 2. The PEARS intervention will lead to increased parent activation around autism diagnosis. |
NICOLE HAMP; | 2022-01-27 |
| 451 | Combined PET and MR Investigations of The Pathophysiology of Gilles De La Tourette Syndrome. Part 2: 7T MRI PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Gilles de la Tourette syndrome (GTS; also known as Tourette syndrome) is a congenital neuropsychiatric disorder. Characteristic symptoms are so-called tics-rapid, repetitive movements (motor tics) or vocalizations (vocal tics) that start suddenly without any apparent purpose. Previous research supports the hypothesis of defective regulation (dysregulation) of the dopaminergic system, with particular discussion of dysfunction of tonic/phasic dopamine release or dopaminergic hyperinnervation. Moreover, given the complex interaction of different neurotransmitters, especially in the basal ganglia, it can be assumed that abnormal dopaminergic transmission also affects other transmitter systems, such as glutamate (Glu) or γ-aminobutyrate (GABA). Furthermore, … |
HARALD E MÖLLER; | 2022-01-27 |
| 452 | Impact of Caffeine, Theanine, Tyrosine Ingestion on Markers of Stress in Response to A Cognitive Challenge and Virtual Reality Active Shooter Drill PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine the effects of caffeine, theanine and tyrosine ingestion on markers of stress in healthy college aged individuals that are exposed to a mental stress task. The main questions to answer are: 1. what is the impact of a mental stress task involving a cognitive challenge and virtual reality based active shooter scenario on markers of subjective and biological stress? 2. what is the impact of supplement ingestion (caffeine, theanine, tyrosine, analyzed separately) 40 min prior to exposure to the mental stress task? |
MATT MCALLISTER; | 2022-01-25 |
| 453 | Identification of Gait Disorders in Children, Adolescents and Young Adults With Rare Genetic Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this pilot study is to explore whether the knowledge and experience gained during the T-GaiD project (Treatment of Gait Disorders in Dravet Syndrome – NCT03857451) can be transferred to another population with similar problems, i.e. motor and gait problems as a result of a genetic disorder characterized by epilepsy and developmental delay. In this pilot study, … |
ANN HALLEMANS; | 2022-01-25 |
| 454 | A Randomized, Double-Blind, Chronic Dosing (12-weeks), Two-Period, Placebo-Controlled, Crossover, Multi-Center Study to Assess The Efficacy, Safety, and Tolerability of Two Doses of L1-79 for The Treatment of The Core Deficits in Social-Communication Interaction in Adolescents and Young Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the efficacy, safety and tolerability of L1-79 in participants aged 12-21 years who have been diagnosed with ASD with a score of >/= 70 on the Wechsler Abbreviated Scale of Intelligence (WASI-II), and a score of >/= 4 on the Clinical Global Impression of Severity of Illness (CGI-S) weighted for socialization. |
RAUN MELMED; | 2022-01-25 |
| 455 | A PHASE I STUDY OF HCT-MSC, AN UMBILICAL CORD-DERIVED MESENCHYMAL STROMAL CELL PRODUCT, IN ADULTS WITH AUTISM SPECTRUM DISORDER PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine the safety and tolerability of a single intravenous dose of Human Umbilical Cord Tissue Derived Mesenchymal Stromal Cells (hCT-MSC) in adults with autism spectrum disorder (ASD). hCT-MSC is a cell product isolated from umbilical cord tissue. The cells from the cord tissue are processed and expanded in the laboratory and then infused intravenously in a single dose per participant. Participants will be ages 18-35 years, … |
JOANNE KURTZBERG; | 2022-01-24 |
| 456 | Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for The Treatment of Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of Autism |
CHADWICK PRODROMOS; | 2022-01-23 |
| 457 | Electrophysiological Markers for Interventions in Phelan-McDermid Syndrome and Idiopathic Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial will use growth hormone as a novel treatment for Phelan-McDermid syndrome (PMS) and idiopathic autism. A double-blind, placebo-controlled crossover trial design will be used in 30 children with idiopathic autism and 15 children with PMS to evaluate the the effects of growth hormone on visual evoked potentials (VEPs), socialization, language, and repetitive behaviors. The researchers expect to provide evidence for the feasibility of using VEPs in PMS, and to show support for growth hormone in ameliorating clinical symptoms of ASD. |
ALEXANDER KOLEVZON; | 2022-01-19 |
| 458 | Optimizing Intervention Options for Toddlers With Early Social Communication Delays PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Improving social communication outcomes for toddler siblings of children with autism, who are at high risk for multiple language and communication deficits beyond autism, has important public health implications. The proposed study is a pilot sequential multiple random assignment trial of 44 high-risk siblings that examines the feasibility, acceptability, and preliminary effects of an adaptive intervention for social communication. Evaluating effective parent-mediated communication support strategies for toddlers at high-risk supports NIDCD’s mission of behavioral research focused on disordered language development and the prevention of health impairments such as communication disorders. |
UNIVERSITY OF TEXAS AT AUSTIN | 2022-01-15 |
| 459 | The Effects of Creatine Supplementation in Autism Spectrum Disorder: A Randomized Placebo-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism Spectrum Disorder (ASD) is accompanied by reduced levels of total creatine in right temporal-parietal junction and other brain regions of interest, and addressing this deficit by exogenous administration of creatine may have beneficial effects on brain metabolism and disease-specific clinical symptoms in patients suffering from ASD. |
UNIVERSITY OF NOVI SAD FACULTY OF SPORT AND PHYSICAL EDUCATION | 2022-01-15 |
| 460 | A Machine Learning Approach for Predicting TDCS Treatment Outcomes of Adolescents With Autism Spectrum Disorders PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disturbances in communication, poor social skills, and aberrant behaviors. Particularly detrimental are the presence of restricted and repetitive stereotyped behaviors and uncontrollable temper outbursts over trivial changes in the environment, which often cause emotional stress for the children, their families, … |
YVONNE HAN; | 2022-01-05 |
| 461 | MRI-Eye Tracking Pairing, A Tool for Assessing Social Cognition in Children With ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Most studies use static visual percepts that are less representative of joint attention versus an ecological environment. This has the consequence of decreasing the perception of an interaction with a social partner, … |
CENTRE HOSPITALIER UNIVERSITAIRE AMIENS | 2022-01-04 |
| 462 | A Randomized Controlled Trial of Parent-mediated Social-communication Therapy for Young Children at Risk for Neurodevelopmental Difficulties Living in Poverty in Brazil PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Exposure to adverse environments such as socioeconomic disadvantage and psychosocial deprivation are risk-factors for neurodevelopmental problems in childhood. Children exposed to such environments may benefit from interventions that target social-communication abilities, since these skills act as protective factors for healthy neurodevelopment in vulnerable children. One early childhood intervention that has shown efficacy in improving early social-communication development is Paediatric Autism Communication Therapy (PACT). However, … |
ALICIA MATIJASEVICH; | 2022-01-01 |
| 463 | Cerebellum and Autism: Regional Specialization for Social and Executive Functions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to determine the impact of neuromodulation to the cerebellum on social and executive functions in neurotypical young adults and young adults with autism. |
CATHERINE STOODLEY; | 2022-01-01 |
| 464 | The More Than Words® Parent-Delivered Program for Autistic Children and Those with Social Communication Challenges: A Single Arm Pragmatic Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Hanen Centre®’s More Than Words® (MTW) program is a globally used, parent coaching intervention delivered by speech-language pathologists (SLPs) to parents of children with social communication challenges, including those who have a confirmed or suspected diagnosis of autism. The training program is designed to provide parents with the tools, strategies, and support they need to help their children reach their full communication and social interaction potential. In this study, … |
JANIS ORAM; | 2022-01-01 |
| 465 | Speech Treatment for Minimally Verbal Children With ASD and CAS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This study tests whether CAS-specific treatment, appropriately modified for minimally verbal children with autism, improves their speech. |
KAREN CHENAUSKY; | 2022-01-01 |
| 466 | Effect of Oculomotor and Gaze Stability Exercise on Writing Capabilities on Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Autism spectrum disorders (ASD)are neurodevelopmental disorders that are clinically characterized by a triad of features: impairments in social interaction, impairments in communication, and presence of restrictive repetitive and stereotypical behaviors, interests, or activities (DSM-IV). In addition to these core deficits, ASD is associated with a high prevalence of fine motor difficulties and executive function impairments that contribute to acquisition and performance of skilled motor tasks. It is therefore not surprising that handwriting difficulties are frequently reported in children with ASD. |
SAMAH MAHMOUD SHEHA; | 2022-01-01 |
| 467 | Establish The Couple Intervention Program for Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The development of adult intimate relationships and the transition into couplehood are part of most people’s life cycles, but these transitions become very challenging for individuals diagnosed with autism spectrum disorder (ASD) in as much as social interactions, emotional communication, and reciprocity, which are essential for interpersonal relationships, are made more difficult due to the condition itself. In the Adult ASD Clinic of National Taiwan University Hospital, we observe that the wives of the ASD husband suffer from long-term frustration, loneliness and helplessness, and are frequently experience anxiety and depression, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2022-01-01 |
| 468 | Autologous Bone Marrow Mononuclear Cell Transplantation Combined With Educational Intervention for Autism Spectrum Disorders (ASD): A Phase 2 Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and effectiveness of autologous bone marrow mononuclear cell infusion combined with educational intervention for children with autism spectrum disorder (ASD). Inclusion criteria: Male/Female patients diagnosed with Autism disorder based on DSM-V scale, the patient is between 3 to 7 years old, a patient has a medium level to server level of autism (CARS score>=30 to <50), VARS-2 >=50, patient’s parent or caregiver must have the educational level of high school or above, … |
LIEMG NGUYEN; | 2021-12-26 |
| 469 | Impact of Early Craniosacral Evaluation and Treatment on The Optimization of Infant Neurodevelopment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Craniosacral exploration and therapy is one of the innovative palpation and treatment techniques in specialized physiotherapy, which can contribute in an efficient, subtle and sudden way to the detection of dysfunctions in the cranial sutures or fontanelles and/or alterations or blockages that may exist in the frontal lobes and other areas of the skull and body. Objective: To demonstrate the need for programs that consider preventive evaluation and specialized physiotherapeutic treatment (craniosacral therapy) in schools and health centers during all stages of child growth (from birth to 12 years of age), maximizing the development of the child’s physical, emotional, psychosocial, … |
GEMA LEÓN BRAVO; | 2021-12-18 |
| 470 | A Randomized, Controlled, Multicenter Study to Evaluate The Safety and Efficacy of Paltusotine in Subjects With Non-pharmacologically Treated Acromegaly (PATHFNDR-2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with non-pharmacologically treated acromegaly. |
CRINETICS PHARMACEUTICALS | 2021-12-17 |
| 471 | CAnnabidiol Study in Children With Autism Spectrum DisordEr (CASCADE): A Double-Blind, Placebo-Controlled Study to Investigate Efficacy and Safety of Cannabidiol in Children and Adolescents With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, placebo-controlled study but all study participants will receive the active study medication at some point during the study for at least 12 weeks, and some children with receive CBD for the entire study. |
NICOLE R TARTAGLIA; | 2021-12-15 |
| 472 | An Intervention Program to Improve Emotion Regulation Among Parents of Children with ASD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine the effectiveness of a short-term therapeutic workshop in improving reflective functioning, the belief that emotions can change, the reported use of effective emotional regulation strategies, and perceived parental self-efficacy and child behavior. |
YAEL ENAV; | 2021-12-14 |
| 473 | Evaluating and Establishing The Relationship in The Five Critical X-ray Time Points in Spinal Deformity Realignment: Preoperative Standing and Supine, Intraoperative Pre- and Post-correction, and Postoperative Standing Films PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To establish the relationship in the five critical X-ray time points during multilevel posterior column osteotomies (MPCO) spinal deformity realignment in patients with adult spinal deformity and to follow the participants longitudinally to examine any follow-up X-rays and clinical data to compare to the post-operative standing scan and pre-operative data. |
JOSEPH OSORIO; | 2021-12-07 |
| 474 | Effect of Aquatic Training Versus Land Exercises on Motor Function in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinically, infants with Autism Spectrum Disorder often display gross motor delays in supine, prone, and sitting skills in their first year of life . Studies reveal that motor abnormalities in Autism Spectrum Disorder can occur very early in developmental trajectory. |
AMIRA MAHMOUD ABD-ELMONEM; | 2021-12-01 |
| 475 | Fatty Acid Supplements Alter Biological Signatures and Behavior in Children With Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the protocol is to test the impact of Omega 3-6 on pre-specified biological signatures (IL-1β, IL-2, and IFNγ) and to correlate changes in the biological signatures with changes in ASD symptoms. |
SARAH KEIM; | 2021-12-01 |
| 476 | The Utility of A Synbiotic With Adjunct Gut-directed Hypnotherapy on The Severity of Gastrointestinal Symptoms in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: CLINICAL ISSUE: Children with Autism Spectrum Disorder (ASD) are four times more likely to suffer with functional gastrointestinal disorders (FGIDs) than their neurotypical peers. The presence of FGIDs are linked to increased undesirable behaviour and ASD severity. Current behavioural approaches for ASD therapy do not alleviate the high comorbidity of FGIDs within this population. BACKGROUND: Dysfunction of the microbiome-gut-brain (MGB) axis has been implicated in pathogenesis of both ASD and FGIDs. Probiotics and prebiotics can modulate the gut microbiome and research has shown efficacy at improving gastrointestinal (GI) symptoms in children with ASD and neurotypical (NT) children with FGIDs. Gut-directed hypnotherapy (GDH) has shown utility in treating FGIDs in NT children and adults but has not yet been trialed in children with ASD. Targeting therapies to address the dysfunction of the bidirectional MGB axis will likely be more effective than either brain/behavioural or gut-based therapy alone. HYPOTHESIS: A synbiotic (prebiotic + probiotic mixture) with combined GDH will be more effective than a synbiotic alone at reducing GI symptoms in children with ASD aged 5.00 to 10.99 years over a 12-week period. |
LEANNE K MITCHELL; | 2021-12-01 |
| 477 | Effect of Naturalistic Teaching Strategies in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will show the effect of naturalistic teaching strategies and picture exchange communication systems in children with an autism spectrum disorder. There will be two groups in this study. One control group and the other experimental group. One group will be provided with the naturalistic teaching strategies and pecs therapy both and the other group will be provided with the PECS therapy. The research will be conducted within the duration of six months after the approval from BASR. The two groups will be first assessed using the portage early education program and pecs manual. After 20 sessions of respective therapeutic techniques, both of the groups will be reassessed. The results of both of the groups will be then compared and conclusions will be drawn. |
NAMEEKA SHAHID; | 2021-11-25 |
| 478 | Theta Burst Stimulation for Refractory Depression in Autism Spectrum Conditions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this research study the investigators aim to learn more about the therapeutic effects of a newer form of non-invasive transcranial magnetic stimulation (TMS), called theta burst simulation (TBS), on refractory depression in Autism Spectrum Conditions. |
ERNEST PEDAPATI; | 2021-11-24 |
| 479 | Physical Activity and Cardiorespiratory Fitness in Adolescents With Autism Spectrum Disorder: Reliability, Validity and Correlates PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to increase knowledge and insights with regard to physical activity behavior in adolescents with Autism Spectrum Disorder. |
TINE VAN DAMME; | 2021-11-18 |
| 480 | Neurofeedback Intervention in Children With Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project aims to: – explore the effectiveness of Neurofeedback therapy for children diagnosed with Autism Spectrum Disorder (ASD) – assess if cognitive functions are affected before and after Neurofeedback Intervention |
SHEMAILA SALEEM; | 2021-11-15 |
| 481 | Comparative Effect of Rhythmic Balance Auditory Vision Training (Bal-A-Vis-X) and Aerobic Training in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the aim of this study is to compare the effects of Rhythmic Balance, Auditory, and Vision Exercises and Aerobic training in children with Autism Spectrum Disorder. |
ARUBA SAEED; | 2021-11-11 |
| 482 | The Study of Risk Factors and Intervention for Children With Chronic Irritability – A Preliminary Approach With Epidemiological, Neuropsychological and Neuroinflammation Studies PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dextromethorphan Added on for Children With Chronic Irritability |
CHIN-BIN YEH; | 2021-11-10 |
| 483 | Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: During the first few decades of life, the brain changes dramatically in shape and function. Sleep lets researchers measure these changes. Researchers want to create a database of sleep and neurodevelopmental data in a group of infants and children to learn more. Objective: To address a knowledge and data gap in the field of sleep and neurodevelopment in infants and children. Eligibility: Children ages 6 months to 76 months who may or may not be at risk for neurodevelopmental and neuropsychiatric disorders. Also, … |
ASHURA W BUCKLEY; | 2021-11-09 |
| 484 | Metabolic Autism Prediction (MAP) Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot clinical trial tests the hypothesis that certain blood metabolite levels can be used to predict Autism Spectrum Disorder (ASD). The study cohort will consist of 200 participants between the ages 18 and 60 months who have been referred to a developmental pediatric center for clinical evaluation of ASD or other developmental delay. Two selected sites will enroll 75 participants each with another 50 typically developing participants. Participants will receive a physical exam (including a dysmorphology evaluation), ADOS, VABS, MSEL, DSM-5, and M-CHAT assessments, and receive a diagnosis. A fasting blood draw is required, … |
RAUN MELMED; | 2021-11-03 |
| 485 | Effects of Sibling-Mediated Intervention on Early Literacy and Social Reciprocity for Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Given the increasing prevalence of autism spectrum disorder (ASD), estimated to be 1 in 68 in the United States alone, ASD has become one of the fastest-growing pediatric concerns. The deficits of children with ASD range across social communication and academic skills. One of the effective interventions that have been used commonly for ASD is the model-lead-test, which includes modeling, prompting children to practice target skills together, and providing children with affirmative feedback or error correction. Previous research has demonstrated that the model-lead-test is successful in teaching different skills for individuals with ASD, including functional, social, … |
CHENGAN YUAN; | 2021-11-02 |
| 486 | Establishing A Diagnostic and Therapeutic Index in Autism Spectrum Disorder (ASD) and Fragile X Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to accumulate and quantitatively analyze data on the microbiome, serotonin signaling and genetics, and inflammatory cytokines from patients with Autism Spectrum Disorder and Fragile X Syndrome. Computational analysis of multi-dimensional datasets will be used to establish a Diagnostic and Therapeutic Index – an objective set of tools that can help differentiate subtypes of Autism Spectrum Disorder and develop more accurate methods of diagnosis and response to treatment. |
JULIA V PEREDERIY; | 2021-11-01 |
| 487 | Improving Health in People With Multimorbidity: A Paradigm Shift in Health Care From Disease-based Curative Models to Personalized Exercise Therapy and Self-management PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic conditions such as knee or hip osteoarthritis (OA), chronic obstructive pulmonary disease (COPD), heart failure (HF), coronary heart disease (CHD), hypertension, type 2 diabetes mellitus (T2DM) and depression are among the leading causes of global disability and affect hundreds of millions of people around the world. In recent years, multimorbidity, commonly defined as the co-occurrence of at least two chronic conditions, has also gained interest due to its substantial impact on the person and society. Despite the significant burden of multimorbidity, … |
SØREN T SKOU; | 2021-11-01 |
| 488 | Early Neurodivergent Developmental Trajectories in Toddlers and Young Children on The Autism Spectrum and Effectiveness of The Early Start Denver Model in Community Settings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Early support is thought to be key to ensure a better quality of life for young children on the autism spectrum. Among early support, different evidence-based approaches have combined the principles of developmental and behavioral science within a naturalistic and interactive frame and grouped under the umbrella of Naturalistic Developmental Behavioral Interventions (NDBI). In the context of NDBIs, the Early Start Denver Model is a manualized support that has reported evidence of efficacy for therapist-, group- and caregiver-implemented support, in multiple research as well as community based settings, different countries and languages (Rogers \& Dawson, … |
LILIANA RUTA; | 2021-11-01 |
| 489 | Evaluating The Antidepressant Efficacy of Transcranial Magnetic Stimulation (TMS) in Patients With Inflammatory Bowel Disease (IBD) and Effects on IBD-related Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Transcranial magnetic stimulation (rTMS) has demonstrated diagnostic and therapeutic potential for a number of conditions and is an approved treatment for depression. Inflammatory Bowel Disease (IBD) has a significant impact on mental health, and comorbid maladaptive behaviors and pain are highly prevalent in patients with IBD and are often under-treated. The investigators predict TMS will improve comorbid maladaptive behavior (heightened interoceptive awareness, sleep, fatigue, catastrophizing, anxiety and depression), reduce pain and improve quality of life in persons with inflammatory bowel disease (IBD). Further, TMS benefits will be associated with changes in gut microbiome as measured by stool, … |
UNIVERSITY OF CALGARY | 2021-11-01 |
| 490 | Effects of A Dog-assisted Therapy on Quality of Life, Work Engagement and Burnout Among Professionals Working in A School for Special Education PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial aims to evaluate the effects of an 8-week program consisting of dog-assisted therapy on the work engagement, burnout, pain, and quality of life among professionals working in a School for Special Education. A total of 30 participants will be involved in the program, which will be comprised of eight 50-min sessions conducted once a week. The hypothesis of the researchers in this study is that this program will achieve a reduction in burnout levels in workers, as well as an improvement in engagement and quality of life. |
DANIEL COLLADO-MATEO; | 2021-10-26 |
| 491 | Brain INvolvement in Dystrophinopathies (BIND): Deep Functional Phenotyping of Duchenne Muscular Dystrophy and Becker Muscular Dystrophy Patients (WP5 and WP6) Part 2: A Neurobehavioural and MRI Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to understand the relationship between DMD and BMD brain comorbidities, and the location of the gene mutation which causes the disease. |
GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST | 2021-10-11 |
| 492 | Effectiveness of Structural-Visual Model Behavioral Approach and Predictive Factors of Cooperativity and Compliance in Dental Examinations for Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study are: 1. Evaluating the effectiveness of the structural-visual model of behavioral approach on the compliance and cooperativity of children with ASD in dental examinations. 2. Analyzing the association between the predicting factors and compliance in the step of dental examination. 3. Analyzing the association between the predicting factors and cooperativity in dental examinations. This study tested two hypotheses: 1. Evaluating the effectiveness of the structural-visual model of behavioral approach on the compliance 2. Evaluating the effectiveness of the structural-visual model of behavioral approach on cooperativity of children with ASD in dental examinations. The participants will undergo the structural visual approach intervention, and the investigator will measure its effectiveness through four assessments: one pre-test and three post-tests. |
ALFINI OCTAVIA; | 2021-10-04 |
| 493 | Examining The Active Ingredients of Consultation to Improve Implementation of A Parent-mediated Intervention for Children With Autism in The Community Mental Health System PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Parent-mediated interventions are considered best practice for treating children with autism spectrum disorder, but these interventions are underutilized in community settings. Implementation strategies like consultation can improve the implementation of these interventions, but little is known about the active ingredients of consultation. This study uses an experimental design (ABCD single-case design with multiple baselines) to identify the active ingredients of a consultation model designed to support the implementation of a parent-mediated intervention for autism spectrum disorder in a low-resourced community mental health system. |
BROOKE INGERSOLL; | 2021-10-01 |
| 494 | Clinical Observational and Statistical Study for Detection of Prevalence and Risk Factors of Disruptive Behavior in Children With Attention Deficit Hyperactivity Disorder (ADHD) Related Papers Related Patents Related Grants Related Experts View Highlight: Identification of prevalence and Risk factors for disruptive behavior in children with Attention Deficit Hyperactivity Disorder and Early recognition of disruptive behavior in children with ADHD |
EMAN SAYED HASSAN MAHROS; | 2021-10-01 |
| 495 | Social Skills in Children With Developmental Coordination Disorder (DCD): A Cross-sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study we will examine the social-communicative skills of children with Developmental Coordination Disorder (DCD) by using online parental questionnaires in children aged 5 to 15y. |
DOMINIQUE VAN DE VELDE; | 2021-09-28 |
| 496 | Exploring Predictors of Response to A Peer-mediated Communication Intervention for Minimally Verbal Preschoolers With ASD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine what child variables (i.e., social attention and peer interest) predict communication gains in response to a peer-mediated intervention for 40 minimally-verbal preschool children with ASD and 80 peers. The Stay-Play-Talk with iPad intervention will be implemented for 8 weeks. Gains in communication and reciprocity with peers will be measured at post-treatment and in non-treatment settings. Another goal is to determine if variance in communication gains accounted for by the two social variables differs based on the pre-treatment measurement context. |
KATHY THIEMANN-BOURQUE; | 2021-09-21 |
| 497 | Use of An Adaptive Sensory Environment in Autism Spectrum Disorder (ASD) Patients in The Perioperative Environment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to prospectively examine the preoperative anxiety scores of ASD patients in an adaptive sensory environment. Additionally, the investigators aim to determine the relationship of severity of sensory integration in ASD patients and their preoperative anxiety scores. The study will also study the family satisfaction with tailored care of their ASD child in the peri-operative environment. |
SEAN ANTOSH; | 2021-09-20 |
| 498 | Exploration of Aquatic Therapy in Children With Autism and Their Families PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an aquatic occupational therapy group for children between the ages of 3-12 that have an autism diagnosis. Intervention will focus on increasing the child’s safety swim skills. |
ERIKA KEMP; | 2021-09-14 |
| 499 | Effect of Dexmedetomidine of Gastrointestinal Motility PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Anorectal manometry requires that the patient be able to respond to command and not receive any medications which could alter muscle tone or motility. In the pediatric population, anorectal manometry can be psychologically challenging to parents and their child, as it is traditionally performed without adjuvant sedation or anesthesia. Sedatives and anesthesia can alter motility and smooth muscle activity, as well as render it difficult or impossible for the child to follow commands required of the study. Patient or parent non-compliance, … |
KEIRA MASON; | 2021-09-14 |
| 500 | A Hybrid Effectiveness-implementation Trial of A School Based Executive Function Treatment for Transition Age Youth With Autism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test the effectiveness of a school-based cognitive behavioral executive function (EF) intervention, Unstuck and On Target High School (UOT:HS), for transition-age youth with autism spectrum disorder (ASD). UOT:HS was designed to be embedded in high schools and delivered by school staff to improve generalization of skills, increase access to mental health care, and fill a gap in evidence-based approaches to support postsecondary transition. UOT:HS targets flexibility and planning skills and focuses on key functions needed for adult success across 26, 1-hour lessons. School staff will be trained to deliver UOT:HS, study staff will provide ongoing check-ins, … |
CARA PUGLIESE; | 2021-09-07 |