Clinical Digest: Recent Clinical Trials on Chlamydia
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Chlamydia. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Chlamydia
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | WHO-recommended Periodic Presumptive Treatment Versus Doxycycline Post-Exposure Prophylaxis for STI Control Among Cisgender Men Who Have Sex With Men in Kenya PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Men who have sex with men (MSM) are at high risk for gonorrhea and chlamydia in Kenya, where nucleic acid amplification testing is not feasible and most infections therefore go undiagnosed. We propose an open-label randomized clinical trial with 2900 participants assigned to WHO-recommended periodic presumptive treatment (PPT) or doxycycline post-exposure prophylaxis (doxyPEP), compared to standard syndromic treatment, with 18 months of follow-up and rigorous culture-based and molecular analysis of antimicrobial resistance in Neisseria gonorrhoeae. This work will provide critical data needed to inform guidelines and improve STI control among MSM in sub-Saharan Africa and other resource-limited settings, … |
SUSAN GRAHAM; | 2025-05-01 |
| 2 | Effect of Aquatic Exercises on Muscle Strength and Quality of Life in Children With Sickle Cell Anemia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sickle cell anemia is a global public health disorder that affects millions of people across the globe. It is an inherited autosomal recessive hemoglobin condition caused by a beta-globin gene mutation that results in an aberrant sickle cell hemoglobin molecule with glutamic acid replaced by valine at position six of the beta-globin chain. Sickle cell anemia is a hereditary illness characterized by persistent microvascular blockage by sickle-shaped cells, chronic hemolytic anemia, and tissue destruction. Red-cell dehydration, hypoxemia, metabolic acidosis, and hyperthermia are typical vaso-occlusive triggers. Children with sickle cell anemia frequently have poor growth and nutritional status, increased protein turnover, … |
EMAN SAMIR SHALTOUT; | 2025-05-01 |
| 3 | STI Self-swab Testing At The Time of Telemed Medication Abortion Provision PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interventional study is to provide more access to STI testing for patients who seek abortion care through telemedicine, particularly for those whose access to STI testing is otherwise limited. The main questions it aims to answer are: What is the acceptability, feasibility, … |
OLIVIA MANAYAN; | 2025-04-30 |
| 4 | Establishing Baseline Sysmex UF-5000 Flow Cytometer Results in Healthy Men PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute urethritis (inflammation of the male urethra) affects millions of men in the United States each year. Effective management of STIs is complicated by asymptomatic infections, as men often delay seeking care until symptoms become severe. Yet, even men without symptoms can show measurable evidence of urethritis. Therefore, a cheap, simple, and non-invasive point-of-care (POC) test, providing results within 30 minutes, could significantly enhance STI management by facilitating early diagnosis and treatment. A new diagnostic method, urine flow cytometry, … |
STEPHEN J. JORDAN; | 2025-04-09 |
| 5 | GODDESS (Gathering Online for Dialogue and Discussion to Enhance Social Support): Engaging Young African American Women in A Virtual Group App to Address Alcohol Misuse, Sexual Risk, and Pre-exposure Prophylaxis (PrEP) in North Carolina (NC) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this trial is to test a modified mobile health intervention (with a group component) relative to a mobile health intervention in a two-arm randomized trial with 500 young African American women who are human immunodeficiency virus (HIV)-negative and who misuse alcohol. The expected outcomes are to: (1) determine the efficacy of the virtual group component in reducing alcohol use and sexual risk and increasing pre-exposure prophylaxis (PrEP) utilization; and (2) understand selected outcomes for implementation. Participants will be randomized to receive either the mHealth app or the mHealth app plus the group component, … |
FELICIA A BROWNE; | 2025-04-01 |
| 6 | Superiority of On-demand Pre-exposure Prophylaxis Versus Post-exposure Prophylaxis on Using Doxycycline for Preventing Sexually Transmitted Infections in Men Who Have Sex With Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effectiveness of doxycycline taken for on-demand pre-exposure prophylaxis (DoxyODPrEP) and its post-exposure use (DoxyPEP) in preventing bacterial sexually transmitted infections (STI), including chlamydia, gonorrhoea, and syphilis among men who have sex with men (MSM). The main questions it aims to answer are: 1. Is DoxyODPrEP superior to DoxyPEP? 2. Are both regimens safe? 3. Does the MSM community accept the use of doxycycline to prevent bacterial STI? Participants will be asked to take doxycycline according to the study arm they are randomly assigned to, … |
TSZ HO KWAN; | 2025-03-29 |
| 7 | A Phase 1/2, Randomized, Placebo-controlled, Multi-arm, Dose-finding Study to Evaluate The Safety, Immunogenicity, and Efficacy of A Chlamydia Trachomatis MRNA Vaccine Candidate in Adults Aged 18 to 29 Years PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety, efficacy, and immunogenicity of different dose levels (low, medium, and high) of Chlamydia messenger ribonucleic acid (mRNA) Vaccine candidate in adult participants aged 18 to 29 years. This study will consist of 3 Sentinel Cohorts and a Main Cohort, with the Sentinel Cohorts assessing the safety of the different dose levels in a stepwise manner. All participants will be followed up to 12 months after the last study intervention administration. Thus, the expected duration of the participant’s involvement will be 18 months. |
SANOFI | 2025-03-17 |
| 8 | Optimizing Mobile Interventions to Overcome Stigma and Promote HIV Prevention Among Thai Young Transgender Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project will develop a multi-component, technology-delivered intervention designed to reduce HIV and intersectional stigma and improve the use of HIV pre-exposure prophylaxis (PrEP) among HIV-negative Thai, young transgender women (18-29 years). |
BO WANG; | 2025-02-20 |
| 9 | Community Burden of Mycoplasma Genitalium Infection and Its Implications for Test-and-treat Strategies PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: To assess the burden and the transmission dynamics of Mycoplasma genitalium (MG) infection in men who have sex with men in Hong Kong. Design and setting: involving a) a cross-sectional study (completion of an online self-administered survey, followed by self-sampling for testing in the laboratory, and performance of HIV self-test); b) a mathematical modelling study to simulate the transmission dynamics of MG infection and resistant MG infection and compare the impacts of test-and-treat strategies. Participants: Around 920 men who have sex with men would be recruited |
NGAI SZE WONG; | 2025-02-18 |
| 10 | A Functional Performance and Acceptability Evaluation of The Miss Liberty Female Condom Compared to The FC2 Female Condom PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the functional performance and acceptability of the Miss Liberty female condom version 1 (Miss Liberty female condom), compared to the FC2 female condom. The study will be a sequential randomised 2-period cross-over trial comparing five uses of the Miss Liberty female condom, compared to the control FC2 female condom. Each woman will be asked to use five Miss Liberty female condoms, and five FC2 control female condoms in a randomised order. Woman will complete a Condom Use Report after each condom use. Function, safety, … |
MAGS BEKSINSKA; | 2025-02-01 |
| 11 | Testing The Efficacy of Safe South Africa: An Intervention to Prevent HIV Risk and Interpersonal Violence Among Adolescent Boys PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, investigators will examine the efficacy of Safe South Africa, a behavioral intervention that is developmentally- and gender-tailored to prevent human immunodeficiency virus (HIV) and intimate partner violence (IPV) among adolescent boys. South Africa faces some of the highest global rates of HIV and IPV with sustained high incidence of HIV and alarming rates of IPV among adolescents and thus, … |
CAROLINE KUO; | 2025-01-22 |
| 12 | Development of A Predictive Model for Sexually Transmitted Infections in Individuals Using Pre-Exposure Prophylaxis for HIV in Spain PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: To develop and validate a predictive model for acquiring sexually transmitted infections (STIs) in individuals using HIV pre-exposure prophylaxis (PrEP) within the national program providing this strategy. Methods: Ambispective cohort study, multicentric (23 Spanish hospitals). All PrEP users, with follow-up within the program, will be included. Entry into the program will be considered as the baseline visit. From there, patients are followed quarterly, following the national protocols for monitoring PrEP users in Spain. At each visit, diagnosis of different STIs (serum, pharyngeal swab, urethral or urine sample, rectal swab, endocervical/vaginal swab, … |
ANAIS CORMA-GOMEZ; | 2025-01-01 |
| 13 | Screen to Prevent: Using Digital Health to Improve HIV Screening and Prevention for Adolescents in The Emergency Department PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this interrupted time series quasi-experimental design study is to implement universal opt- out HIV testing and linkage to HIV preventive care in 15-21 year old adolescents visiting the pediatric emergency department (ED). The main question\[s\] it aims to answer are: 1. What is the uptake, reach and effectiveness of universally offered, opt-out HIV screening across pediatric EDs after implementing an adapted version of a tablet-based screening process? 2. What is the successful linkage to comprehensive HIV pre-exposure prophylaxis (PrEP) care using a novel, … |
JENNIFER L REED; | 2024-12-16 |
| 14 | A Video Intervention on Young Adults’ Fertility Awareness: A Large-scale Educational RCT in Denmark and Norway Measuring Fecundity Knowledge, Fertility Intentions, Reproductive Behavior and Long-run Impacts on Realized Fertility PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This RCT investigates the impact of an educational video on fecundity knowledge among young adults. The video discusses several risk factors associated with fecundity, such as age and smoking. The primary outcome measure of the RCT is fecundity knowledge. The knowledge level is defined based on the following factors: Age; smoking; sexually transmitted infections; Success of spontaneous pregnancy according to female age; Success of pregnancy according to female age and fertility treatment. The secondary outcomes are: intentions regarding the timing of desired pregnancy/childbirth; fecundity-protective behaviors; life goals; realized fertility later in life. |
MIKKO MYRSKYLÄ; | 2024-11-26 |
| 15 | ED2PrEP – Patient Focused, Low-burden Strategies for PrEP Uptake Among Emergency Departments Patients: A Two-arm Hybrid Implementation-effectiveness Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe inequities in HIV pre-exposure prophylaxis (PrEP) access and use in communities hardest hit by the HIV epidemic persist, further exacerbating ongoing racial/ethnic and socioeconomic disparities in HIV incidence. In these same communities, many patients at risk for HIV seek care for sexually transmitted infections (STIs) in Emergency Departments (EDs), but the structure of traditional ED care is poorly suited to address HIV prevention or provide PrEP. To advance the Prevent objective of the Ending the HIV Epidemic (EHE) initiative, … |
URIEL FELSEN; | 2024-10-01 |
| 16 | Association of Helicobacter Pylori Infection With Disease Activity in Systemic Lupus Erythrematosis and Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To find the relation of Helicobacter pylori with disease activity in SLE and RA |
FATMA MOSTAFA MOHAMED AHMED; | 2024-09-04 |
| 17 | A Phase 3 Randomized, Observer-Blind, Placebo-Controlled Study to Assess Efficacy of Meningococcal Group B (rMenB+OMV NZ (Bexsero)) in Preventing Gonococcal Infection Among South African Cis-Gender Women PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This proposed 2-arm randomized evaluation of two doses of 4CMenB vaccine versus placebo at Enrollment and Month 2 is designed as a proof-of-concept study to inform potential use for dual meningococcal B and gonococcal prevention, and to inform Neisseria gonorrheae vaccine development. |
CONNIE CELUM; | 2024-08-14 |
| 18 | The Link Between Human Cytomegalovirus Gene Expression and Glutamate Levels in Migraine :Relationship to The Vit D Deficiency PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To correlate serum 25(OH)-vitamin D level with duration, frequency, and severity of migraine headache attacks 2. To evaluate the relationship between the serum level of vitamin D and other indices in patients with migraine. 3. To correlate the serum level of glutamate with gene expression of in migraine |
AHMED MOHAMED OMAR ALI; | 2024-05-01 |
| 19 | Zenyth: Feasibility and Acceptability of An Motivational Interviewing (MI)-Based Telehealth Intervention for Bacterial Sexually Transmitted Infection (STI) Screening PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the United States (US), gay and bisexual men living with human immunodeficiency virus (HIV) bear a heavy burden of bacterial sexually transmitted infections (STIs) such as gonorrhea, chlamydia, and syphilis. It is important to diagnose and treat STIs in a timely manner to prevent health complications and reduce transmissions. The purpose of this study is to understand whether gay and bisexual men living with HIV are willing to collect and return specimens for bacterial STI testing when combined with live audio/video (AV) conferencing support. |
AKSHAY SHARMA; | 2024-04-19 |
| 20 | Fecal Transplantation in Patients With Colonic Diverticulitis: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the safety and effect of fecal microbiome transplantation (FMT) in patients with a former episode of acute colonic diverticulitis. The main question[s] it aims to answer are: – Is FMT in patients with a former episode of acute colonic diverticulitis a safe procedure without severe adverse events – What is the impact of FMT on patient-reported outcomes and re-admission rate Participants will be asked to: – to ingest either 25-30 capsules with FMT or placebo capsules – Fill-in GI-QLI questionnaire prior to treatment/placebo and 3 months post baseline – … |
THOMAS BJØRSUM-MEYER; | 2024-04-01 |
| 21 | Randomized Controlled Trial in Nepal: Introducing Point-of-care Tests and Identifying Barriers to Reduce Antibiotics for Vaginal Discharge PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine if and how the implementation of point-of care-tests (POCT) for sexually transmitted infections in the management of abnormal vaginal discharge reduces the overtreatment with antibiotics in a low income country. The setting is a university hospital in a semi-rural area in Nepal and several of its rural out-reach-centers. The plan is to include 1500 women attending the gynecological outpatients with a problem of vaginal discharge over approximately a one year period. The main questions the clinical trial aims to answer are: – … |
RISA AM LONNEE-HOFFMANN; | 2024-02-01 |
| 22 | A Phase 4 Study of A 3-Day Vs. 7-Day Regimen of Doxycycline for The Treatment of Chlamydial Infection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 4 blinded, randomized, active-controlled, non-inferiority trial. Persons of any gender identity will be eligible. Final evaluable population will include a minimum 596 individuals: 298 persons assigned female sex at birth (AFAB) with confirmed urogenital chlamydia (CT) and 298 persons assigned male at birth (AMAB) with confirmed rectal chlamydia (CT). Approximately 664 participants will be enrolled to achieve a minimum 596 participants who contribute primary outcome data. Randomization will be stratified by study site and sex at birth: 332 persons assigned female sex at birth (AFAB) and 332 persons assigned male sex at birth (AMAB). Participants will be randomized 1:1 to a 3-day regimen of doxycycline or a 7-day regimen of doxycycline. The study blind will be maintained by providing 7 days of identical pre-filled blister packs, one with 3 days of active treatment and 4 days of placebo, and the other with 7 days of active treatment. Participants will be asked to return 28 days after randomization (at day 29), at which time they will be re-tested for chlamydia (CT) using a laboratory-based chlamydia (CT) nucleic acid amplification test (NAAT). |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2024-01-19 |
| 23 | Screening with Tampons: Evaluating Diagnostic Accuracy for STIs, BV and HPV and Assessing Participant Views PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Diagnostic trial comparing the diagnostic accuracy of the DAYE Diagnostic Tampon (DDT) with a vaginal swab (self-collected and clinician taken). |
LUKE TWELVES; | 2024-01-15 |
| 24 | Evaluating The Effectiveness in Supportive Treatment of Vaginitis of Vaginal-spraying Bacillus Probiotic Spore Suspension (LiveSpo X-Secret) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Vaginitis is a common reproductive infection in women worldwide, particularly in tropical and underdeveloped countries. Traditional antibiotic treatments can disrupt the balance of beneficial bacteria, requiring repeated use, seriously affecting women’s health. Therefore, probiotics are microorganisms that are beneficial to human health when consumed in sufficient amounts, playing an important role in maintaining the balance of the body’s microflora, especially in the intestines and vagina. Many studies around the world have proven that probiotic strains belonging to the genera Lactobacillus, Bifidobacterium, Bacillus, and Saccharomyces can help reduce the incidence and severity of bacterial vaginal infections and yeast infections. However, … |
CHUONG C NGUYEN; | 2023-12-01 |
| 25 | Effect of Oral Probiotic Heat-killed Lactobacillus Johnsonii TCI250 or White Pomegranate Extract on The Vaginal Flora PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to explore the effect of Lactobacillus johnsonii and white pomegranate extract on female bacterial status, it aims to answer are: – Evaluate Lactobacillus johnsonii TCI250 probiotics or white pomegranate extract in regulating female vaginal bacteria and improving vaginal health. – Evaluate Lactobacillus johnsonii TCI250 probiotics or white pomegranate extract in regulating inflammation. Participants will be randomly assigned to placebo (n = 50), probiotic heat-killed Lactobacillus johnsonii TCI250 group (n = 50) and white pomegranate extract group (n = 50) for 8 weeks. Researchers will compare the vaginal flora and inflammation. |
SHIH CHIEN HUANG; | 2023-10-02 |
| 26 | Prevalence of Genital, Anal and Oral HPV Infection and Sexually Transmitted Infections, and of Anal Dysplasia in The Transgender Population (PrevHPV-TG) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to estimate the prevalence of HPV infections anal and ENT level and according to HIV status in transgender (TG) population. The main question it aims to answer is: – What is the prevalence of HPV lesions in transgender population (TG); – What kind of high risk HPV (hrHPV) and low risk HPV (lrHPV) are detected at the genital, anal and ENT level |
JADE GHOSN; | 2023-10-01 |
| 27 | A Digital Patient Decision Aid to Increase Sexually Transmitted Infection Testing in The Emergency Department: The STIckER Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a pilot randomized trial of STIckER in which 40 providers (20 trained in using the STIckER decision aid and 20 providing standard care) will enroll a total of 140 sexually active young Emergency Department (ED) patients over six months in a pediatric and adult ED setting. The primary goal is to determine if sexually active young individuals who use STIckER are more likely to undergo STI testing. By developing an effective automated digital tool to increase STI testing, the investigators aim to improve evidence-based sexual health education, reduce STI rates, … |
JASON E. ZUCKER; | 2023-09-01 |
| 28 | Laparoscopic Tubal Disconnection Versus Laparoscopic Salpingectomy in Infertile Patients Scheduled for IVF/ICSI. Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tubal factor infertility is known to be one of the most common indications for IVF treatment. Patients with hydrosalpinges have been identified to have poor pregnancy outcomes such as lower implantation and pregnancy rates & higher rates of spontaneous abortion and ectopic pregnancies. Surgical intervention can be recommended for patients with hydrosalpinx prior to IVF/ICSI. This study will be done at Ain Shams University Maternity Hospital, to compare laparoscopic salpingectomy & laparoscopic tubal disconnection as two surgical modalities of treatment of unilateral or bilateral hydrosalpinges in women older than 30 years and scheduled for IVF/ICSI, regarding implantation rates, … |
AHMED MOHAMMED ELMARAGHY; | 2023-08-30 |
| 29 | A Pilot Randomized Controlled Trial to Assess A Model of Decentralised STI-Self Testing and Risk Self-Assessment Among Adolescent Girls and Young Women in South Africa to Trigger PrEP Re-start PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot randomized trial among 50 AGYW (aged ≥16≤18 years), who discontinued PrEP use within the past 6 months, assigned in a 1:1 ratio to receive: 1) STI self-test kits (Neisseria gonorrhoea (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV)) with in-person instruction at enrolment and telephone/video-based instructions for home use coupled with self-administered behavioural risk assessment or 2) self-administered behavioural risk assessment only (standard of care). All participants will receive comprehensive sexual and reproductive health (SRH) services during their study visits including choice of family planning method initiation and support, and behavioural HIV/STI risk reduction counselling. |
THESLA PALANEE-PHILLIPS; | 2023-07-05 |
| 30 | A Pharmacist-run, Community-based PrEP Program for High-risk Women-the OPTIMIZE Study Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate uptake and retention of long acting cabotegravir (LA-CAB) also known as Apretude versus daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) also known as Truvada for PrEP among high-risk women in metro-Orlando through week 48 (to also include reasons for lack of retention in PrEP care) |
ORLANDO IMMUNOLOGY CENTER | 2023-06-21 |
| 31 | Meatal Swab Yourself With Testing for Infections Collectively (MYSTIC) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is 1. to improve the accuracy of chlamydia multi-site testing in men who have sex with men (MSM) and trans-women, whilst saving diagnostic costs, by comparing two new pooling methods with the 3-samples tested separately 2. to assess the diagnostic accuracy of pooled specimens for lymphogranuloma venereum detection (LGV) – a type of chlamydia infection Chlamydia and gonorrhoea testing for MSM and trans-women usually involves 3 samples from the throat, bum and wee-pipe. The tests can be combined into a single sample pot (pooled sample) which reduces costs, … |
JANET WILSON; | 2023-05-29 |
| 32 | Trachoma Elimination Study By Focused Antibiotic (TESFA): The Impact of An Enhanced Antibiotic Treatment Regimen on Trachoma in Amhara, Ethiopia PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The study population consists of all households residing in eligible kebeles (sub-districts) within districts in Amhara National Regional State which are identified as having a high prevalence of trachoma and infection measured from recent trachoma impact assessments. Within each study kebele, one village will be randomly selected to serve as the sentinel study site for that kebele. Once these villages are chosen, the study team will use government-provided census records, or perform a census in each village, and will randomly choose 50 children to serve as the sentinel children for the study. After the baseline visit, … |
KELLY CALLAHAN; | 2023-05-01 |
| 33 | IGHID 12118 – Pay-it-forward Gonorrhea and Chlamydia Testing Among Men in China: The PIONEER Pragmatic Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: PIONEER is a three-arm, programmatic cluster randomized controlled trial (RCT) to compare effectiveness of three implementation strategies, followed by a mixed-methods implementation evaluation study |
JOSEPH D TUCKER; | 2023-04-01 |
| 34 | Feasibility and Acceptability of An Electronic Clinical Decision Support Tool for Adolescent Sexual and Reproductive Health Services PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Many studies show early detection of sexual activity in adolescents can improve their health management and that primary care pediatricians would benefit from supports to address adolescent health, including sexual and reproductive health. The primary objective of this study is to evaluate the feasibility, acceptability, and usability of a sexual and reproductive health (SRH) services clinical decision support (CDS) tool within the electronic health record (EHR) among clinicians, adolescent patients, … |
BRIAN P. JENSSEN; | 2023-04-01 |
| 35 | Extraordinarily Fun Training Project in Compulsory Secondary Education-Sexually Transmitted Infections: Educational Intervention on STI in Adolescents From 1st&2nd Year of Compulsory Secondary Education Incorporating The Gender Perspective PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Project FEDE-ITS will improve the STI knowledge and its treatment, of adolescents in the 1st and 2nd year of compulsory secondary education in the intervention group compared to compared to the control group, and will modify the sexual risk practices and the perception of risky practices of alcohol and other drug use during sex of participants in the intervention group compared to the control group. |
DAVID PEDRAZAS-LÓPEZ; | 2023-03-01 |
| 36 | PrEP Rapid Access: An Open Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to determine the feasibility and acceptability of an intervention (Rapid PrEP Access) providing people who inject drugs (PWID) immediate access to PrEP prescriptions through same-day human immunodeficiency virus (HIV) self-testing, … |
SABRINA ASSOUMOU; | 2023-02-01 |
| 37 | Validation of Selected Point of Care Rapid STI Diagnostic Tests for Laboratory Based and Self- Test Use – A Sub-Study of Acceptability Research on Integrated Point of Care Sexually Transmitted Infection (STI) Testing and Expanded Partner Therapy (EPT) (ARISE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this sub-study (PROVE) is to support and facilitate the validation of commercially available point of care (POC) sexually transmitted infection (STI) diagnostic test kits/devices for potential on-site laboratory use as well as bedside use in parallel to gold standard established testing methodologies. A further extension of bedside testing would include self-testing. |
THESLA PALANEE-PHILLIPS; | 2023-01-26 |
| 38 | Integrating Addiction and Infectious Diseases Services Into Primary Care in Rural Settings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate an intervention strategy in introducing screen/evaluate/treat (SET) procedures for HIV/ hepatitis C/ and Opioid Use Disorder in Primary Care Clinics in West Virginia. The main questions it aims to answer are: * What are the barriers and facilitators to integrating evidence based practices for screening and treatment of HIV, hepatitis C, and Opioid Use Disorder into primary care clinics in West Virginia? * To assess the extent to which our SET processes are achieved through enhanced EHR tools, … |
FREDERICK L ALTICE; | 2023-01-24 |
| 39 | Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in Zimbabwe PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective interventional study to evaluate a strategy of point-of-care testing for sexually transmitted infections including chlamydia, gonorrhoea, trichomoniasis, syphilis, and Hepatitis B with comprehensive case management including partner notification in antenatal settings in Harare province, Zimbabwe. |
KEVIN MARTIN; | 2023-01-12 |
| 40 | Impact of A Rapid Test for Gonorrhea and Chlamydia on The Clinical Management of Urethritis and Cervicitis in A Sexual Health Clinic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a pilot randomized controlled trial evaluating the use of either a) rapid 30-minute desktop assay or b) point-of-care gram stain (current standard of care) to guide the clinical management of patients with symptomatic urethritis or cervicitis evaluated in the Massachusetts General Hospital Sexual Health Clinic. Patients presenting with symptoms of urethritis or cervicitis and meeting inclusion criteria will be randomized to have diagnostic specimens tested during the clinical encounter using either the 30-minute desktop assay or point-of-care gram stain. Patients randomized to the intervention arm of the study will also have a gram stain created, … |
INGRID V. BASSETT; | 2023-01-01 |
| 41 | Pan-genome Sequencing of Urine Cell-free DNA for Therapy of Urinary Infectious Diseases: A Single Center Prospective Study Clinical Control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Urinary tract infection is a common infectious disease in clinic. Although urinary tract infection can be initially diagnosed by clinical sign and symptom, signs and urine routine, the application of appropriate antibiotic therapy depends on the further identification of pathogens. Metagenomic sequencing has been widely used in clinical pathogen diagnosis, especially in difficult infectious diseases. ICompared with tissue samples, cerebrospinal fluid, bronchoalveolar lavage fluid, whole blood and other samples, … |
JUNXUE WANG; | 2023-01-01 |
| 42 | Pre-surgical Ultrasound Evaluation for Improving Patient Selection for VNOTES Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is an emerging field in minimally invasive surgery. International consensus-based statement was recently published to help guide the basis for adopting vNOTES into clinical practice, including regarding patient selection. It was agreed that women with potential adhesions are not appropriate candidates for vNOTES approach including women with suspected adhesions due to history of severe pelvic inflammatory disease (PID) or endometriosis. However, as some pelvic infections might be asymptomatic, pre-operation imaging might be beneficial to complete improved selection of patients. Moreover, … |
AYA MOHR SASSON; | 2022-12-01 |
| 43 | Medical Assistance for Procreation Patient Library Targeting Patients With Idiopathic Infertility or Low Ovarian Reserve Before The Age of 35 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Creation of a patient library in Medically Assisted Procreation to allow the implementation of further research with the following objectives: * To identify new relevant biomarkers in patients who will carry a pregnancy to term * To better specify or identify new infertility risk factors * To identify new relevant biomarkers in patients with reduced ovarian reserve Four consultations are planned with biological et clinical collection. |
UNIVERSITY HOSPITAL BREST | 2022-11-11 |
| 44 | Enhancing PrEP Outcomes Among Kenyan Adolescent Girls and Young Women With A Novel Pharmacy-based PrEP Delivery Platform PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will conduct a cluster RCT in Kisumu, Kenya to determine the effect of nurse-navigators on PrEP initiation, persistence, and adherence among AGYW seeking contraception within a pharmacy-based PrEP delivery model. The study will randomize 20 retail pharmacies offering PrEP (10 pharmacies per randomization arm) and will enroll 1900 AGYW seeking contraception. All participants will be enrolled following purchase of a contraceptive method, offered PrEP (daily oral PrEP or the DPV-VR) and followed for 10 months. The study will quantify and compare PrEP initiation, persistence, and adherence at the pharmacy-level between randomization arms, … |
JILLIAN PINTYE; | 2022-11-01 |
| 45 | Using Micro Electro Mechanical Systems to Detect The Air of Vaginal Discharge PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study aims to train the algorithm and assess the performance of the Ainos Flora Women’s Vaginal Health Tester in identifying vaginal infections. |
FUNG-WEI CHANG; | 2022-10-01 |
| 46 | A Savings Intervention to Reduce Men’s Engagement in HIV Risk Behaviors PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized control trial will test an economic intervention to reduce Kenyan men’s engagement in behaviors that increase the risk of HIV/STIs. Participants randomized to the intervention group will be able to open accounts with a partner bank and will be incentivized to save with lottery-based rewards. |
HARSHA THIRUMURTHY; | 2022-07-18 |
| 47 | Assess The Performance of Metagenomic Sequencing in The Diagnosis of STI (NGS-IST) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study will be to assess the performance of the Next-Generation-Sequencing (NGS) diagnostics of Chlamydia trachomatis and Neisseria gonorrhoeae compared to reference techniques. |
LAURE SURGERS; | 2022-07-11 |
| 48 | Assessing The Feasibility and Preliminary Impact of A MHealth App on Reducing STI Risk in Black MSM PrEP Users PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will recruit 120 Black men who have sex with men (BMSM) from the local area, New Orleans. The main purpose of this research study is to test the effect of a new smartphone application, PCheck, on reducing the incidence of STIs, compared to routine care through the LSU-Crescent Care Sexual Health/PrEP Clinic. |
MEREDITH CLEMENT; | 2022-06-01 |
| 49 | Enhancing The A in SAFE: Accelerating Trachoma Elimination in The Republic of South Sudan PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the cost and feasibility of two strategies of enhanced Mass Drug Administration (MDA) of Zithromax to treat trachoma in the Republic of South Sudan. The secondary objectives of this study are to measure trachoma infection outcomes during the 12-month follow-up period among children up to 9 years of age. |
SCOTT NASH; | 2022-05-04 |
| 50 | Expedited Partner Therapy and The HIV Prevention Cascade for MSM in Peru PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The HIV epidemic in Peru remains concentrated in the subpopulation of men who have sex with men (MSM), where the prevalence of disease has been estimated between 10-22% in recent epidemiologic surveys. Partner-based methods to limit the spread of HIV and STI co-infection, including partner notification and partner treatment, provide an important new strategy for HIV control in the region. Expedited Partner Therapy (EPT) has been shown to reduce rates of persistent or recurrent gonorrhea and chlamydia infection in heterosexual patients, … |
JESSE CLARK; | 2022-04-25 |
| 51 | Comparison of The Efficacy of Emergency Two-level and Single Cervical Cerclage in Cervical Insufficiency in The Second Trimester of Pregnancy – Multicenter Prospective Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical insufficiency is defined as painless dilatation of the cervix during the second trimester of pregnancy. As a result of shortening and opening of the cervix, despite the lack of uterine contractions, the fetal membranes invade into the cervical canal and then into the vagina, … |
KATARZYNA KOSINSKA KACZYNSKA; | 2022-03-11 |
| 52 | A Randomized Crossover Study to Evaluate The Efficacy of Antibacterial Mouthwash in Preventing Pharyngeal Gonorrhea Among A High Risk Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine acceptability and preliminary efficacy of daily use of an antibacterial mouthwash as compared to a placebo mouthwash in reducing the incidence of pharyngeal gonorrhea among a cohort of HIV-positive and high risk HIV-negative men. Investigators plan to test the following hypotheses: 1. Participants will maintain a high level of adherence and satisfaction with daily mouthwash use. Furthermore, … |
MARJAN JAVANBAKHT; | 2022-02-17 |
| 53 | PrEPTECH Phase 2 Study: Randomized-Controlled Trial of A Telehealth Intervention Delivering PrEP to Young Men Who Have Sex With Men and Transgender Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PrEPTECH Phase 2 is a 2-arm randomized controlled trial to assess the effectiveness of a telehealth intervention in increasing PrEP uptake among cisgender men and transgender women who have sex with men over six months. Participants (N = 400) will be randomized equally into one of two study conditions, treatment with a telehealth intervention called PrEPTECH or a control condition consisting of treatment as usual plus access to a listing of online and local PrEP resources, … |
REBECCA BRAUN; | 2022-02-12 |
| 54 | Acceptability Research on Integrated Point of Care Sexually Transmitted Infection (STI) Testing and Expedited Partner Therapy (EPT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This protocol builds on nearly a decade of collaborative HIV/STI prevention research to conduct a prospective cohort study of Adolescent Girls and Young Women (AGYW) eligible for PrEP in South Africa in which we will assess the acceptability of point-of-care STI testing plus Expedited Partner Therapy (EPT) and its impact on the incidence of common curable STIs over 12 months of follow-up. The social-behavioral scientist will undertake qualitative interviews with participants and their male partners to identify facilitators and barriers to EPT uptake and conduct a comparative cost analysis to estimate the cost per person tested using point-of-care STI testing with and without EPT incremental to the cost of standard of care. Findings from the proposed research will provide essential knowledge for national policymakers to advance approaches to STI screening and treatment that will lead to improvements in AGYW sexual reproductive health and reductions in STIs. The data generated from this project are essential to inform efforts to reduce the burden of STIs and HIV-1 in women and achieve the 2030 Sustainable Development Goals, which includes substantial reductions in HIIV and STIs in key at-risk populations. This project will support global efforts to substantially reduce STIs in key populations. |
THESLA PALANEE-PHILLIPS; | 2022-02-11 |
| 55 | Cumulative Pregnancy Rate With Lower and Higher Dose of Gonadotropin During Controlled Ovarian Hyperstimulation During IVF Among Expected Poor Responders: A Prospective, Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Controlled ovarian hyperstimulation (COH) is an important step during in vitro fertilization (IVF). Its aim optimally is to recruit 10-15 oocytes. When deciding on the actual treatment, different stimulation protocols, various stimulating agents and wide range of gonadotropin dose can one choose from. Prior to the decision on the actual stimulation protocol and gonadotropin (Gn) dose the patient’s expected response to stimulation is assessed primarily using ovarian reserve markers. Most medications used during stimulation exert their effect in a dose-dependent manner hence with a higher Gn dose one would expect a better response, … |
PETER KOVACS; | 2021-12-02 |
| 56 | Addressing The Continuum of Care Among High-risk Thai Men PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Young Thai men who have sex with men (YMSM) are at high risk for HIV. However, the Thailand National HIV Strategy does not adequately cover HIV prevention for YMSM using specific methods relevant to them, and instead uses a one-size-fits all approach. Partnering with the Thailand Ministry of Public Health (MOPH), the proposed study seeks to finalize, implement and evaluate a multicomponent, multi-level, community mobilization, combination intervention (HUG-M+) to address the entire Continuum of Prevention and Care. The investigators propose to test the efficacy of this approach by conducting research in two Northeastern Thai cities, … |
THOMAS E GUADAMUZ; | 2021-11-27 |
| 57 | A Cluster Randomized Trial of Two Mask Systems (Acteev™ N95 + Acteev™ Fabric Masks Vs. Standard N95 + Fabric Masks During Shifts & in Community) in Preventing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) in HCWs PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A cluster randomized trial will be conducted to evaluate the difference between an Acteev™ system (Acteev™ N95 masks YQD8008 during shifts+ Acteev™ fabric masks in community) and a standard system (standard N95 masks during shifts+ fabric masks in community) in preventing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2)in healthcare workers(HCWs). |
RAINA MACINTYRE; | 2021-11-13 |
| 58 | Same-Day PrEP Initiation and Sexual Health for Transgender Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Transgender women (trans women; assigned male sex at birth but identify as female) are at high risk for HIV infection, and are an important, under-researched population in sub-Saharan Africa. Trans women have a 13 times greater risk of acquiring HIV than adults aged 15-49 years in the general population, and in Africa, trans women have nearly twice the HIV prevalence (25%) of men who have sex with men [MSM] (14%). Oral pre-exposure prophylaxis (PrEP) is an effective prevention tool that could change the trajectory of the HIV epidemic among the 25 million trans women globally, … |
ANDREW MUJUGIRA; | 2021-11-02 |
| 59 | Expanding The Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study utilizes a randomized controlled trial design to evaluate the efficacy of two intervention components for couples HIV testing and counseling (CHTC): a communication skills training video and a substance use module. Participants are randomized in a full-factorial design to one of 4 conditions: CHTC as usual; CHTC + communication skills training videos; CHTC + substance use module; or CHTC plus both adjunct components. |
TYREL STARKS; | 2021-10-13 |
| 60 | Multilevel Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To achieve an AIDS-free generation, there is a critical need for programs which go beyond individual-level behavior change to reduce HIV and STI infections among adolescent girls and young women in sub-Saharan Africa. Informed, Motivated, Aware, and Responsible Adolescents and Adults (IMARA) is an evidence-based HIV-prevention intervention for adolescent girls and young women (AGYW) and their female caregivers, … |
GERI DONENBERG; | 2021-10-02 |
| 61 | Research and Development of An Artificial Intelligence Technology System for Digital Pathological Diagnosis and Therapeutic Effect Prediction Based on Multimodal Data Fusion of Common Tumors and Major Infectious Diseases in The Respiratory System Using Deep Learning Technology PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To improve accurate diagnosis and treatment of common malignant tumors and major infectious diseases in the respiratory system, we aim to establish a large medical database that includes standardized and structured clinical diagnosis and treatment information such as electronic medical records, image features, pathological features, and multi-omics information, and to develop a multi-modal data fusion-based technology system for individualized intelligent pathological diagnosis and therapeutic effect prediction using artificial intelligence technology. |
YANG JIN; | 2021-10-01 |
| 62 | Transgender Men and HIV in Uganda: PrEP Uptake and Persistence PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Transgender men (trans men; assigned female sex at birth but identify as male) are generally thought to be at low risk of HIV acquisition, perhaps because of the assumption that they have sex with cis-gender women. Emerging data from resource-rich settings show that trans men often face many of the same high risks as transgender women (trans women; assigned male sex at birth but identify as female). Trans men report similar rates to trans women of engagement in sex work and engage in unprotected receptive vaginal and/or anal sex with cis-gender men. Additionally, … |
ANDREW MUJUGIRA; | 2021-09-16 |
| 63 | Optimizing A Multi-Modal Intervention to Reduce Health-Risking Sexual Behaviors: Component Selection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this project is to evaluate the components of the app-based intervention Mission Wellness to reduce health-risking sexual behaviors (HRSBs; e.g., condom non-use, multiple sexual partners) in active-duty members of the US Military to improve their sexual and reproductive health (SRH) and readiness to serve. Following the multiphase optimization strategy (MOST) framework, factorial component selection experiments (CSEs) will be conducted to evaluate which five experimental intervention components (i.e., Narratives, Skills, Scenarios, Future, and Risk) elicit the greatest improvements in the outcomes of interest given key constraints. |
RYAN R LANDOLL; | 2021-09-02 |
| 64 | Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective randomized controlled study examines whether the type of glove used (sterile vs clean) for cervical examination to assess progression in labor impacts the rates of intrapartum and/or postpartum infection in patients during labor or induction of labor at term. |
STACY SLAT; | 2021-09-02 |
| 65 | Randomized Controlled Trial (RCT) Comparing Microbiome-driven Embryo Transfer (mET) By EMMA/ALICE Test Vs Conventional Frozen Embryo Transfer (FET) of Blastocysts in Infertile Women at Their First IVF/ICSI Cycle PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Although the endometrium has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome. The uterine microbiome can be defined as Lactobacillus-dominated (<90% Lactobacillus spp.) or non-Lactobacillus-dominated (<90% Lactobacillus spp. with >10% of other bacteria). The presence of a pathogenic microbiota in endometrium was associated with significant decrease in implantation, pregnancy, ongoing pregnancy and live birth rates. Some of these pathogens microorganisms can also produce infection and inflammation that may lead to chronic endometritis. Nowadays, … |
JIE QIAO; | 2021-08-01 |
| 66 | Comparison of Efficacy of Two Combination Regimens for The Treatment of Uncomplicated Neisseria Gonorrhoeae and Chlamydia Trachomatis Coinfection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The frequency of Chlamydia trachomatis and Neisseria gonorrhoeae coinfection can vary depending on their individual incidence and prevalence rates.Single-agent therapy with ceftriaxone is the preferred regimen for treatment of gonococcal infections. If an injectable cephalosporin is not available, cefixime is the only oral cephalosporin that can be used for gonococcal therapy. Doxycycline was recommended for presumptive treatment of chlamydia in nonpregnant individuals with gonococcal infection. The study is conducted to evaluate the effectiveness of two regimens in combination with doxycycline with cefixime or ceftriaxone. |
HAIPHONG UNIVERSITY OF MEDICINE AND PHARMACY | 2021-07-15 |
| 67 | Prevalence and Longitudinal Follow-up Over 2 Years of Anal Lesions, HPV Infection and Associated Sexually Transmitted Infections Among Men Who Have Sex With Men (MSM) in Lomé, Togo PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The DepIST-H study, funded by the French AIDS and Hepatitis Research Agency (ANRS), is to estimate prevalence (the number of cases over a given period of time) and incidence (the number of new cases over a given period of time) of anal lesions (condylomas, dysplasia, cancers) by HIV status among MSM in Lomé, Togo |
CHARLOTTE CHARPENTIER; | 2021-06-24 |
| 68 | Comparing Two Approaches to Care Coordination for High-Cost/High-Need Patients in Primary Care PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Medical care has improved greatly over the past 50 years. Treatments for most medical conditions can help us lead longer and healthier lives, but there are still problems. Many patients with two or more conditions see many different doctors and sometimes take more medications than needed. These patients can feel lost and confused. In addition, non-medical issues involving housing, food, transportation, employment, income, support from others, and language barriers can have a large impact on our health. In Minnesota, … |
LEIF I SOLBERG; | 2021-06-14 |
| 69 | Randomized Trial Leveraging Electronic Health Record Data in A Risk Prediction Model to Increase HIV PrEP Uptake in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Kaiser Permanente Northern California (KPNC) has been a national leader in implementation of HIV preexposure prophylaxis (PrEP), a daily antiretroviral pill that is more than 99% effective in preventing HIV acquisition. However, many patients at risk for HIV at KPNC are not yet using PrEP, resulting in preventable infections each year. In prior work, … |
KAISER PERMANENTE | 2021-06-01 |
| 70 | Population Burden of Sexually Transmitted Infections and Implication for Intervention in Hong Kong PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 5-year cross-disciplinary sexually transmitted infection (STI) project involving a) territory-wide and community-based studies (survey and specimen collection); b) simulation of STI transmission dynamics and comparison of STI intervention strategies through mathematical modelling and cost-effectiveness analysis. The aim of this project is to assess the burden and the transmission dynamics of STIs in the general population and men who have sex with men (MSM) in Hong Kong. Around 1300 sexually experienced adults and 900 MSM would be recruited, 100 participants would be invited for individual in-depth interviews. Main outcome measures include STI history and service preference, … |
NGAI SZE WONG; | 2021-05-13 |
| 71 | PrEP Intervention for People Who Inject Substances and Use Methamphetamine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, PrEP Intervention for people who Inject Substances and Use Methamphetamine (PRIME), we propose to assess if using video directly observed therapy with real-time contingency management (VDOT-CM) may help people assigned male sex at birth who have sex with men (MSM) who inject methamphetamine adhere to PrEP. We will randomize 140 adults who inject substances and use methamphetamine, are HIV-negative, and have recently engaged in a sexual HIV risk behavior to VDOT-CM or counseling alone for 24 weeks. The study aims are to (1) determine the efficacy of VDOT-CM compared to counseling alone for PrEP adherence, … |
PHILLIP COFFIN; | 2021-04-30 |
| 72 | Vaginal Microbiota Transplant to Promote Lactobacillus-dominant Cervicovaginal Communities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis. |
DOUGLAS KWON; | 2021-04-22 |
| 73 | Evaluation of The Congruity of Methods Used in The Diagnostics of Chronic Endometritis in The Course of Infertility and The Effectiveness of Antibiotic Therapy in The Context of Remission of Symptoms and Obstetric Results PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic endometritis (CE) is characterized by the presence of atypical plasma cell infiltrates (CD138 positive) in the endometrial stroma. Recent analyzes suggest that CE adversely affects fertility by reducing endometrial receptivity, impairing decidualization and uterine contractility, thus increasing the risk of recurrent pregnancy loss and implantation failure. It is likely that a significant proportion of idiopathic infertility cases are due to CE. The diagnosis of CE is a challenge because the clinical examination and transvaginal ultrasonography are considered non-specific. The recent scientific research has been aimed at identifying hysteroscopic CE diagnostic criteria and establishing the compatibility of ultrasonographic, hysteroscopic, … |
IWONA MAGDALENA GAWRON; | 2021-04-01 |
| 74 | A Randomized Trial of Doxycycline Chemoprophylaxis for The Prevention of Sexually Transmitted Infections in Gay, Bisexual and Other Men Who Have Sex With Men (gbMSM) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There is a growing epidemic of the bacterial sexually transmitted infections (STIs) syphilis, chlamydia and gonorrhea worldwide; similarly concerning trends have been noted in Canada, where increases of over 160% have been seen in bacterial STIs over the last decade. In Canada, gay, bisexual, and other men who have sex with men (gbMSM) – including those living with HIV – are disproportionately impacted by bacterial STIs5,6These dramatic increases in bacterial STIs, the potential development of serious complications including AMR, and waning effectiveness of the promotion of conventional STI prevention tools (e.g. condoms), … |
JONATHAN TROY GRENNAN; | 2021-04-01 |
| 75 | Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate different screening strategies to decrease the burden of Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV) among pregnant women, and reduce adverse birth outcomes. In turn it aims to evaluate the cost per pregnant woman screened and treated, cost of adverse birth outcomes, and cost-effectiveness per sexually transmitted infection (STI) and disability-adjusted life-year (DALY) averted. Furthermore, … |
ANDREW MEDINA-MARINO; | 2021-03-29 |
| 76 | Contingency Management for PrEP Adherence And/or Methamphetamine UseDisorder Among MSM and TW in Los Angeles: A Pilot Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Use of crystal methamphetamine (MA) leads to changes in sexual risk behavior, adherence to HIV prevention tools, immune response to infection, and tissue inflammation that collectively increase risk for HIV transmission among MA-using men who have sex with men (MSM), their sexual partners, and their networks. Contingency Management (CM) offers a behavioral modification tool helpful for reducing frequency of MA use, but the effects of CM on the behavioral and biological factors that promote HIV transmission in MSM networks have only been partially evaluated. The intersection of substance use, sexual risk behavior, … |
JESSE CLARK; | 2021-03-15 |
| 77 | Genital Tract Infections, The Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This cohort study plans to investigate associations between the presence of multiple lower genital tract microorganisms in pregnancy and gestational age at birth. The study enrols pregnant women at one public health care facility in East London, South Africa. At enrolment and 30-34 weeks of pregnancy, participants provide swabs for testing for sexually transmitted infections, vaginal yeasts and genital mycoplasmas; for microscopy and Nugent scoring; … |
NICOLA LOW; | 2021-03-01 |
| 78 | Real Risks of The Online World: Association of Online Dating Addiction With Mental and Sexual Health Outcomes in Sexual Minorities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Development and validation of questionnaire/scale to assess online dating addiction in a sub-cohort of the SwissPrEPared cohort study (validation sample: n=300). Longitudinal design to assess the association of online dating addiction and sexual/mental health. No randomised trial, only 1 cohort which will be stratified according to severity/risk of online dating addiction. |
UNIVERSITY OF ZURICH | 2021-03-01 |
| 79 | The Diagnosis and Treatment of Chlamydia Trachomatis and Neisseria Gonorrhoeae in Pregnant Women to Prevent Adverse Neonatal Consequences PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the effectiveness of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) testing and treatment during pregnancy to reduce adverse pregnancy and birth outcomes compared to the standard of care (treatment based on symptoms and signs). |
JEFFREY D KLAUSNER; | 2021-02-24 |
| 80 | Investigating The Effectiveness of Innovative Intrauterine Antibiotic Therapy for The Treatment of Patients With Chronic Endometritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Endometritis (CE) is related to infertility and entails a challenging management. This study investigates the treatment of off-label intrauterine antibiotic infusion either separately or combined with oral antibiotic administration, and it assesses respective performance against the gold standard treatment of oral antibiotic adminstration. Data sourced herein reports on treatment efficiency, defined as a negative diagnosis for chronic endometritis. |
KONSTANTINOS SFAKIANOUDIS; | 2021-01-19 |
| 81 | A Phase II Randomized, Observer-Blind, Placebo-Controlled Study, to Assess The Efficacy of Meningococcal Group B Vaccine RMenB+OMV NZ (Bexsero) in Preventing Gonococcal Infection PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase II, randomized, observer-blind, placebo-controlled, multi-site trial of the FDA licensed rMenB+OMV NZ vaccine, Bexsero. The targeted study population is men and women 18-50 years of age who are disproportionately vulnerable to N. gonorrhoeae infection. Approximately 2,200 participants are expected to be enrolled to achieve at least 202 primary endpoints in the Per Protocol Population. Data will be collected in an observer-blind manner. Study product recipients and study staff responsible for the evaluation of any study endpoint will be unaware of whether Bexsero or placebo were administered. The duration of the study for participants who are enrolled and randomized will be approximately 16 months. Study participation is expected to be completed in approximately 36 months. The primary objective of the study is to demonstrate efficacy of Bexsero in prevention of urogenital and/or anorectal gonococcal infection. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2020-12-29 |
| 82 | Prospective Cohort Trial To Assess Acceptability and Efficacy of An Adapted STI/HIV Intervention Behavioral Intervention Program in A Population of US Army Personnel and Their Medical Beneficiaries – Execution Phase PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The hypothesis is that a behavioral intervention tool adapted for the US military population will be acceptable and associated with a decrease in incident sexually transmitted infection (STI)/HIV rates and high-risk sexual behaviors, and increased self-reported condom use compared to the standard of care at the Joint Base Lewis-McChord (JBLM) Preventive Medicine clinic and the Fort Bragg Department of Public Health (part of Womack Army Medical Center). |
TATJANA CALVANO; | 2020-11-04 |
| 83 | Comparison of Cervical Intraepithelial Neoplasia 2/3 Treatment Outcomes With A Portable LMIC-adapted Thermal Ablation Device Vs. Gas-based Cryotherapy PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this academic-industrial partnership will be to compare two thermoablation modalities using devices adapted to low and middle income countries (LMICs) to traditional CO2-based cryotherapy for the treatment of cervical precancer. The investigators will investigate whether the cure rates of cervical intraepithelial neoplasia 2 and more severe diagnoses (CIN2+) with these devices are non-inferior compared to that of conventional cryotherapy. The results of this study will affect other research areas by serving as a springboard to exploring treatment alternatives that are amenable to low-resource settings and thus will reach the most vulnerable populations. |
MIRIAM CREMER; | 2020-10-30 |
| 84 | Pre-exposure Prophylaxis of HIV Infection Among Men Who Have Sex With Men (MSM) and Transgender Women (TG) in Suburban Yangon, Myanmar PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: HIV is concentrated among key populations in Myanmar. Globally, HIV-prevalence among transgender (TG) women is one of the highest; laboratory-confirmed prevalence is reported up to 40%. In September 2015, WHO recommended the use of Pre-Exposure Prophylaxis (PrEP) for people at substantial risk of HIV as part of a combination HIV prevention strategy. A demonstration project will take place to implement and evaluate the uptake and effectiveness of PrEP among MSM, and TG women in a clinic in Hlaingtharyar township, Yangon. The aim is to describe PrEP uptake, as well as HIV-seroconversion and STI infection rates among those who use PrEP. |
NINI TUN; | 2020-10-28 |
| 85 | Peer-Delivered HIV Self-Testing, STI Self-Sampling and PrEP for Transgender Women in Uganda PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Transgender women (TGW) are at high risk for HIV infection, and are an important, under-researched population in sub-Saharan Africa. Globally, HIV acquisition risk among TGW is 13 times higher than other adults aged 15-49 years. In Uganda, HIV prevalence among TGW is 22% compared to 5.9% in the general population. Encouraging use of self-controlled HIV prevention tools – specifically, HIV self-testing (HIVST), STI self-sampling (STISS) and antiretroviral pre-exposure prophylaxis (PrEP) – … |
ANDREW MUJUGIRA; | 2020-10-26 |
| 86 | Phase 3 Double-blind Placebo-controlled Efficacy Trial of EVO100 Vaginal Gel for The Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate whether EVO100 vaginal gel prevents the sexual transmission of CT and GC infection |
EVOFEM | 2020-10-15 |
| 87 | Does Screening for Gonorrhea and Chlamydia Affect The Incidence of These Infections in Men Who Have Sex With Men Taking HIV Pre Exposure Prophylaxis (PrEP): A Randomized, Multicentre Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A Multicentre, controlled, randomized trial of 3 site (urethra, pharynx and rectum) sampling performed every 3 months (3×3) for Neisseria gonorrhoea (Ng)/Chlamydia trachomatis (Ct) screening (comparator) vs. no screening (intervention). |
CHRIS KENYON; | 2020-09-21 |
| 88 | Alignment of PrEP Use With HIV Risk in Young Women and Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Oral pre-exposure prophylaxis (PrEP) is a recommended component of combination HIV prevention and its availability is rising through demonstration projects and full-scale national programs. In sub-Saharan Africa, young women are a priority population for HIV prevention and targeted to initiate PrEP, … |
RENEE HEFFRON; | 2020-08-30 |
| 89 | Satisfaction, Continuity, and Bleeding Patterns in Patients With Breast Cancer Using Copper and Silver Intrauterine Device (IUD) Compared to Copper IUD: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present work seeks an alternative to the copper IUD for contraception in breast cancer patients, evaluating the satisfaction and continuity of the copper and silver IUD, as well as the quality of life, compared to the copper IUD, especially in the regarding the menstrual bleeding pattern of these patients and possible mechanisms that justify such differences. A randomized (1:1) controlled clinical trial is proposed. Women between 18 and 45 years of age, diagnosed with breast carcinoma through histopathological study, who have had at least one vaginal sexual intercourse in life and wish to use intrauterine contraception will be included. |
EDMUND C BARACAT; | 2020-08-06 |
| 90 | Improving The Detection of STIs in The Pediatric Emergency Department: A Pragmatic Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Sexually transmitted infections (STIs) are highly prevalent among adolescents. Despite established principles for STI control, clinical practices related to screening and diagnosis, treatment, and prevention of STIs among adolescents are suboptimal. There is an urgent need to expand our screening programs to nontraditional healthcare settings such as emergency departments (ED) to reach those adolescents who would otherwise not receive preventive healthcare, … |
JENNIFER REED; | 2020-07-20 |
| 91 | Combined Use of A Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Adult Patients With Sickle-cell Disease Hospitalized for Acute Chest Syndrome. A Bi-centric, Open, Parallel-group, Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many patients with Sickle Cell Disease (SCD) may develop Acute Chest Syndrome (ACS). ACS is usually caused by a Lower respiratory tract infection (LRTI) which may be caused by either a bacterium or a virus. Antibiotics are usually used for 7 to 10 days with no microbiological workup. The hypothesis of the study is that the identification of the microorganisms might lead to a reduction of antibiotics exposure and a better care of the patients. We speculate that an early pathogen-directed strategy (respiratory broad panel multiplex PCR and early antibiotics interruption based on the PCT values decrease) might reduce the antibiotics exposure in SCD patients with ACS who are hospitalized and for whom an antibiotic treatment is indicated, as compared with usual care |
MURIEL FARTOUKH; | 2020-06-02 |
| 92 | Genital Chlamydia Trachomatis Treatment to Pregnant Women to Prevent Adverse Pregnancy Outcomes: A Randomized Control Trial Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to identify the relationship between genital C. trachomatis and adverse pregnancy outcomes, and investigate whether screening and treatment of genital C. trachomatis in pregnant women can reduce adverse pregnancy outcomes. Approximately 200 pregnant women from Nanhai Hospital of Southern Medical University in Guangzhou, China will be enrolled and randomized to the intervention or control group. |
WEIMING TANG; | 2020-05-21 |
| 93 | Application of Vaginal-spraying LiveSpo X-secret in Supporting Treatment of Sexually Transmitted Diseases in Vietnamese Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Sexually Transmitted Infections (STIs) are common gynecological infections worldwide, especially in tropical and underdeveloped countries, primarily affecting the reproductive age group. Microbial pathogens causing STIs include bacteria, viruses, fungi, and protozoa. In Vietnam, STIs are a significant public health concern due to their high incidence and tendency to have mild or no symptoms, making them easy to overlook. While antibiotics or antifungal drugs are typically used to treat STIs caused by bacterial or fungal agents such as Chlamydia, Gonorrhea, and Candida, no specific treatment exists for most viral STIs. Thus, … |
HA TV BUI; | 2020-05-03 |
| 94 | Retrospective Study From November 2019 -Febrauary 2020 on Severe Respiratory Illness to Access The Presence or Absence of COVID-19 in Patients Samples By Real-time PcR PF:4 Related Papers Related Patents Related Grants Related Experts View Abstract: A- Methodology adopted in the retrospective study: Sample Size Determination: 500 case presented from November 2019- February 2020 will be included in explore study from Ain shams … |
SARA HASSAN AGWA; | 2020-04-14 |
| 95 | Comparison of Self-taken Penile Meatal Swabs Versus First-catch Urine for The Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Objectives: To compare self-taken penile meatal swabs versus first-catch urine samples for the detection of chlamydia, gonorrhoea and Mycoplasma genitalium from the penile urethra using nucleic acid amplification tests. To assess the acceptability of self-taken penile meatal swabs compared with first-catch urine samples. To assess the prevalence of Mycoplasma genitalium in those with urethritis. To assess the prevalence of Mycoplasma genitalium antimicrobial resistance. To evaluate the utility of using Mycoplasma genitalium resistance-guided therapy. To compare the cost of using self-taken penile meatal swabs versus FCU samples for the correct detection of Chlamydia trachomatis, … |
THE LEEDS TEACHING HOSPITALS NHS TRUST | 2020-04-01 |
| 96 | Arthritis in Assiut University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: – To define prevalence of different types of arthritis in patients attending Assiut University Children Hospital (AUCH) – To define prognosis of these different types – To evaluate management of arthritis in Assiut University Children Hospital, in comparison to international guidelines |
MOHAMED MASOUD ADB-ELMONEM; | 2020-04-01 |
| 97 | Lactobacillus for Luteal Phase Support to Improve IVF Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to evaluate the effect of vaginal lactobacilli, a regulator of normal vaginal flora, on embryo implantation success during IVF / ICSI cycle follow-up. |
GÜRKAN UNCU; | 2020-03-30 |
| 98 | Role of Influenza A VIRus in The Biomolecular Pathogenesis of The Destabilization of Atherosclerotic Carotid Plaques PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Atherosclerosis is the main cause of cardiovascular diseases and is characterized by the accumulation of lipids and inflammatory cells such as macrophages and lymphocytes within the vessel wall of large and medium-sized arteries, forming so-called plaques. The underlying molecular mechanisms are not yet clearly understood. In particular, it is not yet clear what factors can cause the destabilization of atherosclerotic plaques, … |
DANIELA MAZZACCARO; | 2020-02-18 |
| 99 | A Phase I, Double-blind, Parallel, Randomised and Placebo-controlled Trial Investigating The Safety and Immunogenicity of A Chlamydia Vaccine, CTH522, in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present trial is a phase I, double-blind, parallel, randomised, and placebo-controlled trial of a chlamydia vaccine CTH522. Sixty-six subjects will be randomly assigned into six cohorts and are to receive four vaccination, … |
KATRINA POLLOCK; | 2020-02-17 |
| 100 | PrEP and DPEP: Doxycycline Post-exposure Prophylaxis for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV Pre-exposure Prophylaxis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized clinical trial of doxycycline post-exposure prophylaxis (dPEP) to reduce bacterial STIs among Kenyan women taking pre-exposure prophylaxis (PrEP). The overarching goal is to assess the effectiveness of dPEP on incidence of STIs while also balancing acceptability, cost, and impact on tetracycline resistance to inform public health policy. Participants will be randomized to receive dPEP and standard of care or the standard of care only. Questionnaires, focus group discussions, SMS, and in-depth interviews will be used to study acceptability and changes sexual behavior due to dPEP. |
JARED BAETEN; | 2020-02-05 |
| 101 | Impact of The Daily Doxycycline Pre-exposure Prophylaxis (PrEP) on The Incidence of Syphilis, Gonorrhoea and Chlamydia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. This study is a non-randomized observational cohort trial using before and after comparison to evaluate intervention 2. It would mimic the conditions that would occur outside a clinical trial. 2. After consent and enrolment, … |
BRIDGET HAIRE; | 2019-12-17 |
| 102 | Comparison of Current Standard of Care Versus The Australian Guidelines for Management of Mycoplasma Genitalium Infections Among Men Being Treated for Non-gonococcal Urethritis PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this protocol is to determine the difference in clearance of Mycoplasma genitalium (MG) when using the Australian management protocol versus the current Centers of Disease Control (CDC) treatment guidelines for US standard of care (SOC), to determine the proportion of men from the Deep South, with NGU attributable to MG, and to determine the proportion of MG cases that harbor the macrolide-resistance associated with mutation. |
BARBARA VAN DER POL; | 2019-11-19 |
| 103 | A Multi-site Multi-Setting Randomized Controlled Trial (RCT) of Integrated HIV Prevention and HCV Care for People Who Inject Drugs (PWID) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to compare and evaluate two strategies of delivering PrEP and Hepatitis C Virus (HCV) treatment to people who inject drugs to determine the best method of providing care. Participants will be randomized to one of two treatment arms: on-site integrated care or off-site referral to specialized care. |
LISA METSCH; | 2019-11-14 |
| 104 | OpTImisation of Methods for A Human INfection Model for Group B Streptococcus PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Group B Streptococcus (GBS) is the leading cause of neonatal sepsis and meningitis. In 2015, it was estimated that worldwide there were at least 320,000 infants with invasive GBS disease, 90,000 infant deaths and 10,000 cases of children with disability related to GBS meningitis. Maternal rectovaginal colonization with GBS is the biggest risk factor for neonatal GBS sepsis and meningitis within the first 6 days of life, … |
CATHERINE COSGROVE; | 2019-11-04 |
| 105 | Effects of Social Comparison Performance Feedback on Primary Care Quality PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: As part of UCLA Health’s commitment to developing a premier integrated health system built on a foundation of physician-led, team-based primary care, the Department of Medicine (DOM) recently implemented a new performance based incentive plan called the Primary Care Clinical Excellence (PCCE) Incentive Plan. This incentive plan was developed to motivate providers to improve health maintenance screening rates. The UCLA Health DOM Quality team is leading the implementation and evaluation of this new incentive plan across our primary care network. In addition, … |
DANIEL M. CROYMANS; | 2019-11-01 |
| 106 | Evaluation of EHealth Videos for The Singaporean Gay, Bisexual and Queer Male Community PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a pragmatic, randomized controlled trial design to evaluate an online video series developed by a community-based organization in Singapore for gay, bisexual and queer men. A total of 300 HIV-negative, gay, bisexual and queer men in Singapore aged 18 to 29 years old will be recruited with the assistance of the partner community-based organization (CBO), Action for AIDS Singapore. Recruitment will utilize both online and offline channels, and with the help of other CBOs in Singapore. Participants should also not have watched the video prior to their participation in this study, … |
TAN KAY JIN RAYNER; | 2019-10-13 |
| 107 | Randomized Open-label Study of The Impact of Prolonged Systemic Corticosteroid Therapy on The Course and Relapse Risk of Checkpoint Inhibitor Interstitial Lung Disease (Pneumonitis) Related to The Treatment of Solid Tumors With Anti-programmed-death Type 1 Receptor or Ligand Antibodies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective interventional open-label randomized trial. The patients treated with anti- PD-1 (programmed-death receptor type 1) or anti-PD-L1 (programmed-death ligand) antibodies in case of new acute onset interstitial changes or new seriuos respiratory system related symptoms will be recruited for this study to perform diagnostics. At the recruitment the patient will be randomized 1:1 to investigatory or control arm, … |
MATEUSZ POLACZEK; | 2019-10-01 |
| 108 | Pilot Peer Mentor Intervention to Train Black MSM to Use and Promote Home-based HIV and STI Testing PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of the study are to assess the feasibility, reach and preliminary efficacy of a brief intervention that trains Black men who have sex with men [referred to as Index] (a) to use home-based testing for HIV and sexually transmitted infections and (b) promote home-based testing to their peers and sexual partners. |
JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH | 2019-09-30 |
| 109 | Clinical Evaluation of The Click Sexual Health Test for The Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) in Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-center study with a minimum of three CLIA-waived intended operator sites in the United States in which prospectively self-collected vaginal specimens obtained from subjects who are symptomatic or asymptomatic for CT, NG, or TV will be evaluated with the Click Sexual Health Test in a Clinical Laboratory Improvement Amendments (CLIA) waived setting. Subjects interested in participating in this study will be assessed for eligibility and asked to give informed consent and assent, if applicable, by the Investigational Review Board (IRB). Only those subjects who meet the inclusion and exclusion criteria may be enrolled in the study. |
VISBY MEDICAL | 2019-09-16 |
| 110 | The Effect of Ibuprofen on The Endocrine and Metabolic Status of Women With PCOS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Polycystic ovary syndrome occurs in about 10% of women of childbearing age. His pathogenesis is not fully understood. More and more research concerns the role of chronic inflammation in these women as the cause of the disease. In vitro studies have shown a significant reduction in testosterone production by teak cells after ibuprofen. The goal of the project is to use a low dose of ibuprofen in women with PCOS to lower androgen levels. |
BEATA BANASZEWSKA; | 2019-09-01 |
| 111 | The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after a patient’s water bag has ruptured prematurely. If a patient has been diagnosed with rupture of their water bag between 18 0/7 weeks and 22 6/7 weeks and there are no other associated complications with the pregnancy, … |
ROBERT C MOORE; | 2019-08-28 |
| 112 | Are Rectal and Genital Chlamydia Trachomatis Infections in Women Related to Anal Sex, Autoinoculation / Contamination PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Chlamydia trachomatis is the most common cause of sexually transmitted bacterial infection in Sweden, an infection that is notifiable according to the Communicable Diseases Act and the Communicable Diseases Ordinance. Women account for 57 % of all cases detected since 1993. Recently published studies describe a high proportion of positive rectal chlamydia tests in women and in half of the cases there is no history of anal sex. In almost 20 % of cases, chlamydia has only been found rectally. Samples in these studies were self-collected and although the sensitivity of modern NAATs (Nucleic Acid Amplification Tests) is very high, … |
NAPOLEON KENTARCHOS; | 2019-08-27 |
| 113 | A Randomized, Placebo-controlled Trial of Oral Doxycycline for The Prevention of Syphilis in HIV-positive Men Who Have Sex with Men (MSM) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Syphilis is a sexually transmitted infection (STI) disproportionately affecting gay, bisexual and other men who have sex with men (gbMSM), with the potential for significant sequelae – particularly in those who are Human Immunodeficiency Virus (HIV)-positive. Rising rates of this STI have prompted a search for novel prevention solutions. A recent pilot study of daily doxycycline prophylaxis demonstrated promise as a novel STI prevention tool. This innovative approach to STI prevention has solid clinical precedent, both from the HIV pre-exposure prophylaxis (PrEP) literature, … |
JONATHAN TROY GRENNAN; | 2019-08-15 |
| 114 | Kyaterekera Project: A Combination Intervention Addressing Sexual Risk-Taking Behaviors Among Vulnerable Women in Uganda PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Guided by Social Cognitive and Asset theories as well as Behavioral Economics (BE) principles,the proposed RCT is carefully designed to test the additive contributions of savings-led microfinance beyond traditional HIV risk reduction (HIVRR) alone in decreasing biologically confirmed STIs, including HIV, improving high risk behavioral outcomes, while concurrently reducing income from sex work. Working within established health care- and outreach-based settings, we will randomly assign 990 FSWs to one of three study arms (11 town centers each): (1) a control arm comprising treatment as usual (TAU) for FSWs (quarterly 2-3 hour health education sessions, HIV testing services, and STI screening), … |
FRED SSEWAMALA; | 2019-08-01 |
| 115 | Multi-Center Clinical Performance Evaluation of The NeuMoDx™ Chlamydia Trachomatis (CT) / Neisseria Gonorrhoeae (NG) [CT/NG] Assay on The NeuMoDx™ 288 Molecular System and The NeuMoDx™96 Molecular System PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This investigational study will be conducted to evaluate the performance of the NeuMoDx™ CT/NG Assay on the NeuMoDx™ 288 Molecular System and NeuMoDx™ 96 Molecular System (collectively referred to as NeuMoDx™ CT/NG Assay test system). |
NEUMODX MOLECULAR | 2019-07-22 |
| 116 | Improving Antibiotic Use in Urgent Care Facilities Through Implementation and Evaluation of Core Elements of Outpatient Antibiotic Stewardship PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will implement a comprehensive outpatient stewardship program targeting a large network of Urgent Care (UC) clinics within Intermountain Helathcare. |
EDDIE STENEHJEM; | 2019-07-01 |
| 117 | Innovative Tools to Expand HIV Self-Testing PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The I-TEST study builds upon two participatory approaches, open challenge contests and entrepreneurship training. The study utilizes open challenge contest to generate youth-driven interventions on strategies to promote HIV self-testing and other testing for other sexually transmitted infections (STIs) among young people in Nigeria. Open challenge contests involves leveraging on the knowledge and strengths of the crowd (in this case young people) to generate solutions to an issue. Following completion of one of the open challenge contest, … |
JULIET IWELUNMOR; | 2019-07-01 |
| 118 | Computer-Assisted Motivational Interviewing Intervention to Facilitate Teen Pregnancy Prevention and Fitness Behavior Changes: A Randomized Trial for Young Men PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study aims to test and rigorously evaluate the effectiveness of a computer-assisted motivational interviewing (CAMI) intervention that has already been shown to be successful with young women by reducing the risk of rapid subsequent birth among adolescent mothers, and applying this intervention to young men. The purpose of the intervention is to increase condom use, increase female partner use of moderately or highly effective contraception, … |
DAVID L. BELL; | 2019-06-01 |
| 119 | Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project is designed to remedy unaddressed and interlocking HIV-prevention and mental health needs among gay and bisexual men (GBM) in the Central Eastern European country of Romania, and their underpinning stigma-related mechanisms. Rampant stigma contributes to the increasing prevalence of HIV among Romanian GBM (from under 10% in 2009 to close to 20% in 2014, by best available estimates) and keeps GBM out-of-reach of HIV-prevention services. An mHealth pilot intervention (titled Despre Mine. Despre Noi. [DMDN] translated as About Me. About Us.), … |
CORINA LELUTIU-WEINBERGER; | 2019-05-20 |
| 120 | A Double-blind Single Center, Crossover, Randomized Controlled Trial of Antibacterial Vs. Placebo Mouthwash to Reduce The Incidence of Gonorrhea/Chlamydia/Syphilis in MSM Taking HIV Pre-exposure Prophylaxis (PrEP) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study involves a randomized placebo controlled trial that aims to assess if a mouthwash (Listerine cool mint, LCM) is able to reduce the cumulative incidence of gonorrhoea (Ng), chlamydia (Ct) and syphilis in men who have sex with men and receiving preexposure prophylaxis (PrEP) at the Institute of Tropical Medicine (ITM). |
CHRIS KENYON; | 2019-04-03 |
| 121 | Comparing Specimen Collection Techniques to Screen for Sexually Transmitted Infections in Pregnant Women: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to compare two specimen collection techniques (vaginal vs. endocervical swab) to screen for sexually transmitted infections in pregnant women. Either a physician or the patient may collect the vaginal specimen; … |
KRISTA JENSEN; | 2019-03-12 |
| 122 | Acceptability and Efficacy of Self-sampling for Cervical Cancer Screening: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In Singapore, the current cervical cancer screening uptake among women in Singapore has remained at low 50% since its introduction in 2004. It has been widely reported that under-screened women have the highest risk of cervical cancer. Self-sampling HPV DNA screening may be a solution to the low uptake rates of local women, particularly among the under-screened population in Singapore. Self-sampling comprises women using a swab to obtain samples from their vagina. In this study, … |
NATIONAL UNIVERSITY HOSPITAL SINGAPORE | 2019-03-01 |
| 123 | Protecting Our Future: Promotion of Protective Sexual Health Practices Among Native American Youth and Young Adults Through An Assets-based Self-care Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research protocol is to test the efficacy of a self-care intervention through a randomized controlled trial (RCT), for increasing protective sexual health behaviors among youth in the participating Native American community. The investigators will randomize 450 youth and young adults ages 14-26 to the self-care intervention or a control program. Efficacy data will be collected up to 6 months post-intervention. The primary outcome will be uptake of sexually transmitted infection (STI) screening. Secondary outcomes will include: a) sexual risk and protective behaviors; … |
LAUREN TINGEY; | 2019-03-01 |
| 124 | Pivotal Study of A Single-Use, Point-of-Care Molecular Diagnostic Device for The Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) in Women PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center study with a minimum of three sites in the United States. The study will enroll approximately 1750 female subjects, 14 years of age and older, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2019-02-27 |
| 125 | A Within-subject Laboratory and Field Trial to Test The Use of Commercially Available Insect Repellents Against Contact From Musca Sorbens, The Putative Vector of Trachoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Musca sorbens, a fly that feeds from ocular and nasal discharge on humans, is thought to be the vector of trachoma. We are developing methods of fly control that specifically target this species, in the hope of interrupting Ct transmission. To our knowledge, the use of commercially available insect repellents has never been tested for prevention of Musca sorbens fly-eye contact (i.e. nuisance and landing in the peri-ocular area). Given the likely necessity for prolonged and/or high frequency fly-eye contact for Ct transmission, … |
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE | 2019-01-10 |
| 126 | Treatment of Infective Endocarditis By Vancomycin and Gentamycin in Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Infective endocarditis is a microbial infection of the endocardial surface of the heart. |
SARAH SOBHY HABIB; | 2019-01-01 |
| 127 | Pay-it-forward Gonorrhea and Chlamydia Testing Among Men Who Have Sex With Men in China: A Cluster Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled trial which will evaluate dual gonorrhea/chlamydia test uptake and other outcomes in men who have sex with men (MSM) in three trial arms – 1) a pay-it-forward testing arm, 2) a pay-what-you-want testing arm, and 3) standard of care arm. |
JOSEPH D TUCKER; | 2018-12-08 |
| 128 | Getting to Zero: Safer Conception Programming to Eliminate Sexual and Perinatal HIV Transmission Among HIV Sero-different Couples in Uganda PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite effective strategies to reduce periconception HIV transmission, there are few services to support people living with or affected by HIV to use these methods. In particular, there is a lack of safer conception services focused on engaging men living with HIV. Given known gender inequities in childbearing decision-making and HIV risk, it is critical that safer conception services deliver programming that engages men living with HIV and their HIV sero-different partners. The Healthy Families program, based at the ISS Clinic at Mbarara Regional Referral Hospital, … |
ANGELA KAIDA; | 2018-11-26 |
| 129 | Multicenter Epidemiologic Study of Severe Community Acquired Pneumonia in China PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is aimed to understand the clinical characteristics, etiology and resistance phenotype of major pathogens of SCAP in China through multicenter and prospective investigation. Thus to provide epidemiological basis for improving the SCAP diagnosis and treatment protocol suitable for China. |
JIEMING QU; | 2018-11-10 |
| 130 | Project PRIDE: Intervention to Reduce HIV Risk in Young Sexual Minority Men PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The specific aims are to: 1. Pilot test a randomized controlled trial of Project PRIDE for feasibility for subsequent research projects. A sample of 123 men aged 18-25 who identify as gay, bisexual, queer, or some other non-heterosexual identity, who are HIV negative, who report at least once instance of condomless anal sex in the absence of PrEP in the past 60 days, and who report drug use at least once in the past 60 days will be recruited and randomized to one of two conditions: 1. Project PRIDE: an eight-session primary HIV-prevention intervention; … |
NATHAN G. SMITH; | 2018-11-09 |
| 131 | Use of A Rapid Turnaround Test for Gonorrhea & Chlamydia to Improve Treatment of Women Presenting With Possible Sexually Transmitted Infections PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the effect of utilizing a rapid turnaround CT/NG test on treatment of female patients in the emergency department or urgent care setting with possible STIs. |
RICHARD GENTRY WILKERSON; | 2018-09-24 |
| 132 | Vaginal Self-sampling for Rapid Turnaround Gonorrhea/Chlamydia Testing in The Emergency Department PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Consenting adult female patient felt by the provider to require gonorrhea/chlamydia endocervical testing will be asked to provide an additional self sample specimen. The specimen will be sent to the laboratory using conventional diagnostic test for gonorrhea/chlamydia. |
BRIAN CHINNOCK; | 2018-09-17 |
| 133 | UROGEN WEL-DONE: Can The Novel Rapid Diagnostic UROGEN WELL D-ONE Detect Common Causes of Urinary Tract Infections and Urethritis? PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: UROGEN WELL D-ONE Principal research question: Can the UROGEN WELL D-ONE assay detect urinary tract infections and urethritis in clinical samples from patients attending Genitourinary Medicine outpatient clinics as accurately as standard laboratory microscopy and culture methodologies, … |
LUCY C JONES; | 2018-09-05 |
| 134 | HIV Pre-exposure Prophylaxis Implementation Study in South Korea PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to examine acceptability, patterns of use, rates of adherence, safety , and measured levels of drug when high risk men who have sex with men (MSM) are provided open-label tenofovir/emtricitabine (TDF/FTC) for PrEP in South Korea. Secondary objectives are 1) to evaluate HIV incidence among study participants, 2) to evaluate risk behavior and risk compensation among study participants, and 3) to identify barriers and facilitators of PrEP among study participants. The design of this study is a prospective, … |
JUN YONG CHOI; | 2018-08-28 |
| 135 | A Phase 4, Randomized, Double-Blinded, Placebo-Controlled Trial of Azithromycin Versus Doxycycline for The Treatment of Rectal Chlamydia in Men Who Have Sex With Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A clinical trial to compare the efficacy of azithromycin (Arm 1) vs. doxycycline (Arm 2) administered per CDC’s STD Treatment Guidelines for rectal Chlamydia trachomatis (CT) in men who have sex with men (MSM). Subjects will be males aged = / > 18 years with a microbiologically confirmed diagnosis of rectal CT and at least one male sex partner in the past 12 months. The trial will be conducted at two sites in the US and will enroll up to 274 total subjects to achieve 246 subjects who contribute to the primary analysis. The duration of this study will be approximately 16 months 22 months with subject participation duration 29 days. The primary objective of this study is to compare the efficacy of azithromycin vs. doxycycline for treatment of rectal CT infection in MSM based on microbiologic cure (negative NAAT) at Day 29. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2018-07-13 |
| 136 | Clinical Study of A Single-Use, Point-of-Care Molecular Diagnostic Device for The Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) Utilizing Vaginal Swabs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center study with a minimum of three sites in the United States. The study will enroll approximately 1750 female subjects and will have a study duration of approximately 9 months after enrollment of the first subject. Female subjects seen at the participating sites for any reason will be evaluated for enrollment in this study. All subjects will be managed per standard of care as applicable. Subjects who are enrolled in the study will perform self-collection of a vaginal swab to be tested by Click device, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2018-07-09 |
| 137 | Randomized, Open-label, Multicenter Study of Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to A Vaginal Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chlamydia trachomatis is the most commonly reported bacterial sexually transmitted infection (STI), especially among young women. Up to 75% of C. trachomatis infected women are asymptomatic. If untreated, C. trachomatis infection can cause sequelae such as pelvic inflammatory disease, ectopic pregnancy and tubal factor infertility. C. trachomatis can also cause anorectal infections, which are typically asymptomatic. Among women with urogenital chlamydial infection, around 36-91% also had concurrent anorectal chlamydial. Notably, there was no association with anal intercourse in the studies that reported it. However, guidelines do not recommend routine anorectal testing, … |
BERTILLE DE BARBEYRAC; | 2018-07-01 |
| 138 | Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium By Real-time Multiplex Polymerase Chain Reaction After Pooling Pharyngeal, Anorectal and Urinary Samples, in Men Who Have Sex With Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare the sensitivity of detecting Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium by real-time multiplex PCR in a pooled analysis (i.e. gathering pharyngeal, anorectal and urinary samples) versus the standard of care (where a real-time multiplex PCR is made in each of the three samples). |
THIERRY PRAZUCK; | 2018-06-29 |
| 139 | Prevalence of Sexually Transmitted Infections (STIs) at Entry Into Prison in Reunion PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Since the beginning of the 2000s, there has been a steady increase in the incidence of STIs in France. In Reunion, the few figures available seem to show the same phenomenon, especially for syphilis. The unfavorable socio-economic context, which is characterized by high levels of precariousness, significant population exchanges (immigration, travel) with neighboring countries, … |
MARIE-PIERRE MOITON; | 2018-06-19 |
| 140 | Evaluation of Presumptive Periodic Treatment (PPT) of Sexually Transmitted Infections (STIs) Among High-risk Populations Including Men Who Have Sex With Men, Female Sex Workers (FSW) and Mining Populations in Tanzania PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Sexually transmitted infections (STI) are important causes of reproductive health morbidity and mortality, and have long been implicated as major co-factors in the sexual transmission of HIV. Both ulcerative and non-ulcerative STI have been found to be strongly associated with HIV in cross-sectional and prospective studies and hence STI prevention and care are important aspects of HIV prevention. Periodic Presumptive Treatment of STIS (PPT) where risk populations are presumptively treated with a single dose of Azithromycin+Cefixime in regular intervals of 3 months has been shown to be effective in reducing STI prevalence at population level and has recently been integrated into the National STI guidelines of Tanzania. The USAID funded Sauti program will be one of the first to implement these new guidelines and roll out PPT in high risk populations in selected regions in Tanzania. This study will evaluate the impact of PPT as delivered by the Sauti program on prevalence of STIs in men who have sex with men and female sex workers in Dar es Salaam and Shinyanga respectively. |
AMANI SHAO; | 2018-05-14 |
| 141 | A New Approach to Integrating Primary and Secondary HIV Prevention in Young Male Couples PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Young gay, bisexual, and other men who have sex with men (YMSM) are the only risk group in which rates of new HIV infections are on the rise. There has been a relative dearth of research dedicated to understanding these health disparities between gay/bisexual and heterosexual youth, and even less has focused on identifying factors that might promote resilience against negative health outcomes. Understanding both risk factors and processes of resilience is critical in developing efficacious interventions to improve health in this population. Through a grant from the National Institutes of Health, … |
MICHAEL E. NEWCOMB; | 2018-04-05 |
| 142 | Phase IIa Prospective Study to Evaluate The Safety and Measure Efficacy of Anti-chlamydophila Antibiotic Combination (ACAC) Therapy Comprising 100mg Doxycycline, 500mg Azithromycin and 300mg Rifabutin in The Treatment of Patients With Coronary Heart Disease (CHD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to see whether the antibiotic combination of 100mg doxycycline, 500mg azithromycin and 300mg rifabutin is a safe and effective treatment for coronary artery disease which has not responded to ‘standard treatment’. Coronary artery disease is the process of plaque build up within the walls of the arteries responsible for supplying the heart with oxygen and nutrients. plaque is usually made up of fatty deposits, minerals and various amounts of tissue and white cells which eventually narrows the artery, … |
THOMAS BORODY; | 2018-04-04 |
| 143 | Suubi4Her: A Combination Intervention Addressing HIV Risk Behaviors Among Older Adolescent Girls Transitioning Into Adulthood in Uganda PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines the impact and cost associated with Suubi4Her, an innovative combination intervention that aims to prevent HIV risk behaviors among 15-17 year-old girls living in communities heavily affected by poverty and HIV/AIDS in Uganda. Participants will be randomly assigned at the school level into one of three study conditions: 1) Savings (Youth Development Accounts – YDA) – with a 1:1 incentive match rate – for education and microenterprise development; 2) Savings (YDA) + Multiple Family Groups intervention; … |
FRED SSEWAMALA; | 2018-03-23 |
| 144 | The PREMISE Trial: A Novel Regimen to Prevent Malaria and Sexually Transmitted Infections in Pregnant Women With HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: More than 3 billion people worldwide are at risk of acquiring malaria and pregnant women living with HIV in Africa are at particular risk. An effective prophylaxis regimen capable of preventing malaria and other common perinatal infections would have great potential to improve adverse birth outcomes. The purpose of this randomized controlled trial is to evaluate a new combination prophylaxis regimen in pregnant women with HIV in Cameroon to determine its efficacy and safety. |
JODIE DIONNE-ODOM; | 2018-03-07 |
| 145 | Couples Health Project: Couples-based Intervention to Reduce Drug Use and HIV Transmission Risk PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project tests the feasibility, acceptability, and preliminary efficacy of the Couples Health Project (CHP). CHP is a brief (3-session) couples-based Motivational Interviewing intervention which addresses drug use and sexual HIV transmission risk among partnered HIV negative YMSM (ages 18-29). The proposed project includes a randomized controlled trial (RCT) involving 50 couples who are randomized to complete either the CHP intervention or an attention-matched education control condition. |
TYREL STARKS; | 2018-03-06 |
| 146 | Delivery of Audiovisual Information on Early Medical Abortion to Women in Europe Via Digital Technology: Is It Acceptable and Informative? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The majority of abortions in the United Kingdom (UK) are performed before 9 weeks (63 days) gestation using a method known as Early Medical Abortion (EMA). EMA involves an assessment visit and provision of two types of medication . The assessment visit usually involves Ultrasound to confirm gestation, detailed personal history, safeguarding assessment and contraception planning, before arranging treatment and follow up. The process is long and lots of information is given to women attending the service. In NHS Lothian (National Health Service, Lothian Health Board), … |
JOHN REYNOLDS-WRIGHT; | 2018-03-05 |
| 147 | Youth-focused Strategies to Promote Adherence to Pre-exposure Prophylaxis Among Youth At-risk for HIV in Thailand PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized controlled clinical trial looking at the effect of use of a mobile phone application in addition to standard care compared to standard care alone at a youth-friendly clinic in young men who have sex with men and transgender women aged between 15-19 years at risk of HIV on PrEP adherence. |
WIPAPORN NATALIE SONGTAWEESIN; | 2018-03-01 |
| 148 | Non-Eosinophilic Neutrophilic Asthma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Define and characterize the neutrophilic phenotype of severe asthma. |
FUNDACIÓ INSTITUT DE RECERCA DE L’HOSPITAL DE LA SANTA CREU I SANT PAU | 2018-02-21 |
| 149 | Intervention to Reduce Drug Use and HIV Incidence Among High PrEP Priority Partnered YMSM PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research examines the efficacy of an individually-delivered intervention tailored for YMSM in relationships. The intervention – termed PARTNER – utilizes a brief (4 session) motivational interviewing format to target Pre-Exposure Prophylaxis (PrEP) uptake/adherence, HIV transmission risk behavior, and associated drug use. |
TYREL STARKS; | 2018-02-14 |
| 150 | Fathers Raising Responsible Men (FRRM): Addressing Sexual Health to Reduce Teen Pregnancy PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: While existing teen pregnancy prevention efforts have contributed to significant declines in the overall U.S. teen pregnancy rate, teen pregnancy prevention programs specifically targeting adolescent males are limited and sorely needed. The primary aim of the proposed research is to further develop, evaluate, … |
VINCENT GUILAMO-RAMOS; | 2018-01-03 |
| 151 | Enhanced SexHealth Intervention to Improve Adolescent Outcomes: A Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an adaptive trial with an initial Formative Revision Process followed by a Randomized Controlled Trial (RCT). Up to 500 adolescents will be consented into this study to achieve 6 completed subjects for the formative process and 86 completed subjects for the RCT. |
MELISSA MILLER; | 2017-12-01 |
| 152 | Phase 2B Double-blind Placebo-controlled Efficacy Trial of EVO100 (Previously Known As Amphora ® Gel) for The Prevention of Acquisition of Urogenital Chlamydia Trachomatis Infection PF:4 Related Papers Related Patents Related Grants Related Experts View Abstract: Primary: To determine if intravaginal EVO100 reduces the risk of urogenital Chlamydia trachomatis (CT) infection. Secondary: To determine if intravaginal EVO100 reduces the risk … |
EVOFEM | 2017-11-03 |
| 153 | A Structural HIV Prevention Intervention Targeting High-risk Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the effectiveness of a community based combination HIV prevention package, including biomedical, behavioral, and structural services for female sex workers (FSW) in Baltimore, Maryland. This study is a prospective two-group trial comparing the efficacy of a community-based comprehensive HIV/STI prevention package compared to standard of care (HIV testing, counseling, and referrals) among FSWs. Outcomes will be assessed through self-reported illicit drug use and sexual risk behaviors (behavioral) as well as HIV/STI testing (biological). |
SUSAN SHERMAN; | 2017-09-14 |
| 154 | The Impact of Legionella Urine Antigen Testing (LUAT) on The Local Epidemiology and Diagnosis of Legionella Pneumonia – A Hospital Based Study in Malaysia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: There has never been a paper published or research done to determine the rate of Legionella species as a cause of community or nosocomial acquired pneumonia requiring hospitalization in Malaysia. Anecdotally, Legionnaires’ disease is thought to be uncommon in Malaysia. This is one of the first prospective hospital-based studies to comprehensively evaluate the epidemiological and demographical factors of patients hospitalized with Legionella infection in Malaysia. |
ALBERT ANTHONY; | 2017-09-12 |
| 155 | Chlamydia Tracomatis and Other Lower Genital Tract Infections Among Women With Unexplained Early Miscarriage PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Although one fourth of pregnant women experience at least 1 abortion, yet only 50% of causes are identified. Pregnancy loss can result from viral, bacterial, and other infections. It can reach the fetoplacental units through blood born or local spread. Lower genital tract infections- a potentially preventable infections- was suggested as a cause of spontaneous miscarriage. It was reported in 15 and 66% of early and late miscarriages respectively. These infections are also commonly encountered among apparently healthy looking pregnant women with an overall prevalence of 40-54%. If left untreated it can lead to premature rupture of the membranes, … |
SAHAR MY ELBARADIE; | 2017-09-01 |
| 156 | Treatment Failure and Associated Predictors Following Azithromycin Treatment for Urogenital Chlamydial Infection in Males in Youth Correctional Facilities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study is a single center (with multiple long-term YCFs) treatment trial of the CDC-recommended azithromycin regimen (1 gm PO once) for chlamydia in males. This study is designed primarily to determine the frequency of chlamydia treatment failure following azithromycin in males who do versus do not have urethral symptoms of urethral discharge and/or dysuria. Anticipated enrollment is 446 males, between the age of 12 to 21 years old, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2017-08-24 |
| 157 | Efficacy of Couples-Based HIV Prevention in Vulnerable Young Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Young gay, bisexual, and other men who have sex with men (YMSM) are the only risk group in which rates of new HIV infections are on the rise. There has been a relative dearth of research dedicated to understanding these health disparities between gay/bisexual and heterosexual youth, and even less has focused on identifying factors that might promote resilience against negative health outcomes. Understanding both risk factors and processes of resilience is critical in developing efficacious interventions to improve health in this population. Through a grant from the National Institutes of Health, … |
MICHAEL E. NEWCOMB; | 2017-08-21 |
| 158 | A Randomized Controlled Trial Comparing Cure Rates of Cervical Intraepithelial Neoplasia Grade 2 and Higher (CIN2+) Treated With CO2-based Cryotherapy, CropPen, and Thermoablation (UH3) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this academic-industrial partnership will compare the CryoPen® and thermoablator to traditional CO2-based cryotherapy for the treatment of cervical precancer in low and middle income countries (LMICs) and investigate whether the cure rates of cervical intraepithelial neoplasia 2 and more severe diagnoses (CIN2+) with these devices are non-inferior compared to that of conventional cryotherapy. The results of this study will affect other research areas by serving as a springboard to exploring treatment alternatives that are amenable to low-resource settings and thus will reach the most vulnerable populations. |
MIRIAM CREMER; | 2017-08-01 |
| 159 | Mobile-Based Application MyChoices to Increase Uptake of HIV Testing, Detection of New HIV Infections, and Linkage to Care and Prevention Services By Young Men Who Have Sex With Men PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is testing the acceptability and feasibility of MyChoices, a mobile application (app), to promote HIV testing and pre-exposure prophylaxis (PrEP) uptake among young men who have sex with men (YMSM). |
KENNETH H. MAYER; | 2017-07-01 |
| 160 | Re-enrolling Young South African Mothers in School As A Social Vaccine Against HIV Transmission PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the efficacy of an intervention designed to reduce STI/HIV incidence by increasing the number of adolescent mothers who re-enroll and remain in school. The objective of the intervention is to have older mentor mothers, who themselves were pregnant adolescents, to mentor younger adolescent mothers. Mentor mothers will provide ongoing psychosocial support, help navigate re-admission to school, and help facilitate access to an existing State-sponsored cash transfer, the child support grant (CSG), … |
ALLISON K GROVES; | 2017-06-26 |
| 161 | A Cohort for Evaluation of Open-label PrEP Delivery Among Kenyan and South African Women: The POWER Cohort PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The POWER Cohort study is a PrEP implementation project to demonstrate Pre-exposure prophylaxis (PrEP) delivery for young women in Cape Town and Johannesburg, South Africa and Kisumu, Kenya. |
CONNIE CELUM; | 2017-06-14 |
| 162 | STD Testing in Outpatient Practices-The STOP STDs Study PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: National guidelines have recommended routine STD screening (chlamydia and gonorrhea) for sexually active young women under the age of 25. Despite these recommendations, many young women are not being screened for STDs, with some estimates that less than 50% of women receiving health care are screened for chlamydia. Untreated STDs can lead to important sequelae to women’s reproductive health including pelvic inflammatory disease, … |
HAROLD WIESENFELD; | 2017-06-12 |
| 163 | A New Approach to Controlling Chlamydia Transmission in Young People PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study, named Check it, is a bundled program for African American (AA) men ages 15-24 that includes community testing for chlamydia and gonorrhea, expedited treatment for subjects who test positive and their female sexual contacts, and rescreening for these two sexually transmitted infections. |
PATRICIA KISSINGER; | 2017-05-22 |
| 164 | Prevalence of Sexually Transmitted Infections Among People Attending The Sexual Assault Centre in Oslo, Norway: A Cohort Study at The Sexual Assault Centre in Oslo, Norway PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study the investigators seek to register the prevalence of sexually transmitted infections (STI) among people attending the Sexual Assault Centre in Oslo, Norway. The main aim of this study is to gather representative data on STIs after sexual assaults. Consequently, if the attendance for medical follow up turns out to be good/sufficient, prophylactic (antibiotic) treatment can potentially be omitted. |
ODD MARTIN VALLERSNES; | 2017-05-01 |
| 165 | Evaluating The Effectiveness of An EHealth EBI for Latino Youth in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test the relative effectiveness of a Hispanic-specific eHealth intervention, e-Health Familias Unidas, in preventing and reducing drug use, sexual risk behaviors, and STIs among Hispanic youth in primary care. Families will be recruited through four pediatric primary care settings. Pediatric staff and research team members, including nurse assistants and mental health professionals, will implement eHealth Familias Unidas. |
GUILLERMO PRADO; | 2017-04-18 |
| 166 | Performance of Nucleic Acid Amplification Tests for The Detection of Neisseria Gonorrhoeae and Chlamydia Trachomatis in Extragenital Sites PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to use participant samples to simultaneously evaluate three nucleic acid amplification tests (NAATs) diagnostic platforms. |
JEFFREY D KLAUSNER; | 2017-04-10 |
| 167 | The Effect of Social Media Support and Financial Incentives on Adherence to HIV Pre-exposure Prophylaxis in Young MSM of Color in Washington, DC PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if social media support and financial incentives improve adherence to Truvada as PrEP in African American, Latino and Asian MSM aged 18 to 24 living in the Washington, DC area who are at high risk for HIV acquisition. |
MARC O. SIEGEL; | 2017-04-01 |
| 168 | Ovarian Tissue Freezing For Fertility Preservation In Women Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to obtain ovarian tissue from female participants who will receive therapy which is expected to result in a loss or impairment of ovarian function and/or infertility and wish to preserve (freeze) ovarian tissue for the purpose of initiating a pregnancy in the future. Removal of the ovary for cryopreservation is an investigational procedure. 100% of the tissue will be used for the participant’s future use. There have been 86 pregnancies as a result of frozen ovarian tissue that has been re-implanted back into the pelvis and hormonal function has been restored in individuals for up to 7 years. By doing this study, the investigators hope to learn of how to successfully freeze and thaw ovarian tissue in a manner that permits subsequent use by patients at some point in the future. Participation may also advance our knowledge of how to successfully mature follicles and oocytes (eggs) that are contained in these tissues which may help others in the future. |
VLAD RADULESCU; | 2017-02-01 |
| 169 | Prevention of Diseases Induced By Chlamydia Trachomatis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to determine whether early screening and treating young women (<25 years of age) for genital Chlamydia Trachomatis (Ct) infection reduces the cumulative incidence of pelvic inflammatory disease (PID) over 24 months. As secondary objectives, the study aims - To determine the baseline prevalence and the incidence of Ct infection; - To improve knowledge on natural history of Ct infection in young women such as the rate and timing of progression to PID (at the beginning of the infection, at the end, throughout the course of infection), ... |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2017-01-10 |
| 170 | Evaluation of An Inpatient Sexual Risk Behavior Assessment Program PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an exploratory pilot study to evaluate the feasibility and potential effects of an innovative, individualized electronic inpatient sexual health intervention (iRAP) for adolescent females. The central hypothesis is that the electronic intervention, a sexual health questionnaire with tailored feedback based on the Trans Theoretical Model (TTM) of behavior change, will significantly increase adolescent females’ requests for sexually transmitted infection (STI) screening and sexual health management during their hospital admission. |
RHODE ISLAND HOSPITAL | 2017-01-04 |
| 171 | Prevention of Chlamydia Infection With Theater in School Sex Education – A Randomized Controlled Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study evaluated if interactive theater in school sex education affects student knowledge, attitudes and behavior regarding condom use. The intervention group got a play, value exercises, chlamydia games, condom school and interactive replay with professional actors and staff from a youth guidance center. The control group got standard sex education from school staff, based on the education guidelines of the Swedish National Agency for Education. |
ANNSOFIE ADOLFSSON; | 2016-12-01 |
| 172 | Gender-Affirmative Medical Care to Improve HIV Treatment Cascade Among Transgender Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Public health strategies are urgently needed to improve HIV disparities among transgender women, highly burdened by the epidemic globally, including holistic approaches that address those health needs prioritized by the community. To address this urgent need, a three-phase implementation science study of an integrated HIV service delivery model that combined HIV prevention and treatment services with gender-affirming primary medical care for transgender women was implemented in Lima, Peru, supported by peer navigation to improve outcomes across the HIV continuum of care: regular HIV testing for HIV-uninfected participants and linkage to preventive services; … |
JAVIER R LAMA; | 2016-10-01 |
| 173 | Use of Condoms in Prevention of Progression of Cervical Intraepithelial Neoplasia: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Women who are diagnosed with CIN2 and who have a pregnancy wish are followed up 6 months after the diagnosis with new examinations. The regression rate is based solely on the woman’s own ability to clear the cervical lesions. The use of condoms has shown a relatively good protective effect against Human Papillomavirus (HPV) infection. It has furthermore been indicated that condoms increase the regression rate of cervical lesions. The hypothesis of this study is that the regression rate of cervical intraepithelial neoplasia grade 2 (CIN2) increases when condoms are used consistently in the follow-up period of 6 months. |
MALENE SKORSTENGAARD; | 2016-09-01 |
| 174 | A Phase I First in Human, Double-blind, Parallel, Randomised and Placebo Controlled Clinical Trial of The Safety of SSI’s Adjuvanted Chlamydia Vaccine CTH522 in Healthy Women Aged 18 to 45 Years PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present trial is a phase I first in human, double blind, parallel and placebo controlled trial of SSI’s adjuvanted chlamydia vaccine CTH522: CTH522-CAF01 (CAF01 is an adjuvant system) and CTH522-Al(OH)3. The trial will be conducted at Imperial College Research site in the United Kingdom. Subjects are randomly assigned to one of the following three treatment groups in a ratio of 3:3:1. This trial consisted of 10 visits and 5 telephonic interviews |
SONYA ABRAHAM; | 2016-07-01 |
| 175 | Emergency Department, Rapid Assessment for Sexually Transmitted Infection PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate if a rapid urine Nucleic Acid Amplification Testing (NAAT) is non-inferior to the traditional swab NAAT for gonorrhea and chlamydia when performed in the Emergency Department. |
JOSEPH MILLER; | 2016-06-01 |
| 176 | Changing The STI Care Model to Reduce Genital Inflammation and HIV Risk in South African Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this prospective cohort study is to determine if a model of care including point-of-care testing, immediate therapy, expedited partner therapy and test of cure will result in a higher cure rate and a lower recurrence rate of sexually transmitted infections (STIs), with a subsequent reduction in genital inflammatory cytokines and hence HIV risk among young women in a high burden setting in KwaZulu-Natal, South Africa. The study will identify individuals with STIs using the GeneXpert system for the simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis, … |
NIGEL GARRETT; | 2016-05-15 |
| 177 | Pilot Feasibility Study: Recruiting African American Fathers and Their Adolescent Sons for Qualitative, Sexual Health Research PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop and pilot test recruitment methods for a future study of prevention of sexually transmitted infections (STI), including the human immunodeficiency virus (HIV), among Black adolescent boys through sexual health education by their fathers. |
SCHENITA RANDOLPH; | 2016-05-09 |
| 178 | A Couple-based HIV Prevention Intervention to Promote HIV Protection Among Latino Male Couples PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epidemiological studies have attributed the source of many new HIV and STI infections among MSM to primary partners. Despite recent emphasis on couples-based interventions, efficacious interventions for Latino male couples have yet to be tested. The proposed study builds on the PI’s post-doctoral research in which he adapted evidence based intervention for Black MSM couples, Connect ‘n Unite, for Latino male couples using methodologically rigorous adaptation procedures. The adapted intervention, Conectado Latinos en Parejas (CLP) expands the prevention alternatives offered in previous interventions by incorporating biomedical prevention methods such as pre-exposure prophylaxis (PrEP), promoting engagement in care, … |
OMAR MARTINEZ; | 2016-05-01 |
| 179 | Understanding Transmission of Genital and Extra-genital Chlamydia Trachomatis Infections in Women Receiving Routine Care; Implications for Control Strategies PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicenter prospective cohort study in Chlamydia trachomatis positive women after regular treatment to understand the transmission of anorectal CT infections. |
MAASTRICHT UNIVERSITY MEDICAL CENTER | 2016-04-01 |
| 180 | Fertility After Myomectomy Versus Uterine Artery Embolization for Symptomatic Uterine Fibroids Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose of this study: To establish the superiority of myomectomy versus Uterine Artery Embolization, in women with multiple symptomatic fibroids and no other infertility factor, seeking to conceive. |
ANTOINE TORRE; | 2016-04-01 |
| 181 | Impact of Long-Acting Progestin Contraception on The Vaginal Microbiome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite many years of research, controversy persists as to whether hormonal contraception promotes HIV acquisition. A number of observational studies on depot medroxyprogesterone acetate (DMPA) injection showed an increase in HIV risk and no evidence of increased risk with oral contraceptive pills. There are no human studies currently published on the impact of the levonorgestrel intrauterine device (LNG IUD) on HIV transmission risk and minimal data on the effects of the etonogestrel subdermal implant (ESI) on risk of HIV acquisition. Establishing whether any of these highly effective contraceptives increases the risk of HIV infection would have far-reaching public health implications, … |
WENDY KUOHUNG; | 2016-03-01 |
| 182 | A Randomized Study Evaluating An Intervention Integrating Economic Strengthening and HIV Prevention Programs for Vulnerable Youth in South Africa PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates whether the integration of an Economic Strengthening program with an HIV-prevention education program produce synergistic effects on economic and health outcomes for South African youth ages 14-17 years old. |
HOLLY BURKE; | 2016-02-01 |
| 183 | Pilot of An MHealth-enhanced, Safer Conception Intervention to Reduce HIV-1 Risk Among Kenyan HIV-1 Serodiscordant Couples PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The greatest burden of the HIV-1 epidemic lies in sub-Saharan Africa, where a substantial proportion of infections occur in long-term heterosexual HIV-1 serodiscordant partnerships. Such couples face a difficult dilemma when considering their desire to have children: forego condom use, attempt to conceive and risk HIV-1 transmission or continue condom use and relinquish their childbearing desires. Based on evidence from rigorous clinical trials demonstrating the strong efficacy of individual interventions for HIV-1 prevention and formative work with HIV-1 serodiscordant couples and clinicians with expertise in HIV-1 prevention and reproductive health in the Kenyan context, … |
RENEE HEFFRON; | 2016-02-01 |
| 184 | Sanitation, Water, and Instruction in Face-washing for Trachoma I/II PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: SWIFT I is a series of 3 cluster-randomized trials designed to assess several alternative strategies for trachoma control in communities that have been treated with many years of mass azithromycin distributions. The first trial (named WUHA) compares communities that receive a comprehensive Water, Sanitation, and Hygiene (WASH) package to those that receive no intervention. The second trial (named TAITU-A) compares communities randomized to targeted antibiotic treatment versus those randomized to mass antibiotics for trachoma, … |
JEREMY D KEENAN; | 2015-12-05 |
| 185 | Multimedia HIV/STI Prevention for Black Drug-Involved Women on Probation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study is a randomized controlled trial (RCT) that will rigorously evaluate the effectiveness and cost-effectiveness of delivering a multimedia evidence-based intervention (WORTH) and streamlined HIV testing to prevent human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs) with Black/African-American (hereafter referred to as Black) women drug users in probation sites in New York City (NYC), compared to streamlined HIV testing alone. Repeated assessments will occur at baseline and 3, 6, and 12-months post intervention. The primary outcomes will be to reduce cumulative incidence of biologically confirmed STIs (i.e., Chlamydia, … |
LOUISA GILBERT; | 2015-11-15 |
| 186 | Validity of Patient-Collected Wet Mounts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose/Objectives: To compare wet mount findings for clue cells, yeast, trichomonads and white blood cells per high-power field in self-collected vaginal specimens, compared to clinician-collected specimens, among symptomatic women visiting the San Antonio Metropolitan Health sexually transmitted disease clinic. Research Design/Plan: Prospective, non-randomized, non-blinded trial Methods: Obtain informed consent and specimens from 40 symptomatic adult females (eg abnormal discharge, odor and/or itching). Calculate concordance between clinician- and patient-collected samples using a Wilcoxon Matched-Pair test. Calculate sensitivity, specificity, positive predictive value and negative predictive value of the patient-collected wet mount, … |
JUNDA WOO; | 2015-11-01 |
| 187 | Evaluation of The Use of The Colli-Pee Device to Collect First-void Urine for Molecular Detection of Several Sexual Transmitted Infections, Including Reproducibility of The Test Results and Acceptability By MSM Participating in A PrEP Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study objectives: – To evaluate the usability of the Colli-PeeTM device to collect first-void urine for nucleic acid detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and Mycoplasma genitalium. – To collect feedback on the easiness of use and the willingness of future use of the Colli-PeeTM device. |
INSTITUTE OF TROPICAL MEDICINE BELGIUM | 2015-09-01 |
| 188 | Culturally Congruent HIV Risk Reduction App for Young Women, An Acceptability & Pilot Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Smartphone applications and mobile technologies offer users the potential to access critical information (e.g., proper condom use, directions to testing sites, and other sexual and reproductive health services) when it is needed most. Relevant findings will identify areas where existing interventions may be leveraged and adapted to work among young women of color in an urban setting and their networks. As SRH smartphone apps continue to proliferate, this study will expand researchers’, developers’, and health educators’ limited knowledge about the feasibility, acceptability and preliminary efficacy of a sexual health educational app tailored with and for young Black and Latino women, … |
CITY UNIVERSITY OF NEW YORK SCHOOL OF PUBLIC HEALTH | 2015-07-01 |
| 189 | Randomized Controlled Trial of An Adapted STD Screening and Risk Reduction Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this research study is to evaluate the impact of a paraprofessional-delivered, culturally adapted, evidence-based intervention (EBI) on sexually transmitted disease (STD), substance use and poor mental/emotional health among American Indians (AI) through a Randomized Controlled Trial (RCT). These intertwining risks have produced marked disparities and have unique cultural and social determinants in Native communities. If aims are achieved, scientific knowledge and community-based practice will be advanced in areas vital to AI communities, and to STD and drug prevention science. Prior to this study, … |
LAUREN TINGEY; | 2015-07-01 |
| 190 | A Study Comparing The Stability for Human Papillomavirus Testing of Three Dry Vaginal Self-samples Taken By Women Attending A Colposcopy Clinic PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 60 women from the Colposcopy Clinic at the Royal London Hospital will be recruited, having been referred following an abnormal cervical screening result. Aim Human Papillomavirus (HPV) is very common and can cause cervical cancer in some women. There is interest in HPV testing in place of the smear test currently used for cervical screening. HPV testing has potential for women to take self-samples. These self-samples have up to now mostly been placed into liquid to preserve them before testing. Using liquid however, … |
MANGESH A THORAT; | 2015-07-01 |
| 191 | Reducing Diagnostic Errors in Primary Care Pediatrics PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposal will focus on 3 specific, high-risk, pediatric ambulatory diagnostic errors each representing a unique dimension of diagnostic assessment: evaluation of symptoms, evaluation of signs and follow-up of diagnostic tests. Adolescent depression (i.e. symptoms) affects nearly 10% of teenagers, is misdiagnosed in almost 75% of adolescents and causes significant morbidity. Pediatric elevated blood pressure (signs) is misdiagnosed in 74-87% of patients, often due to inaccurate application of blood pressure parameters that change based on age, … |
MICHAEL RINKE; | 2015-06-01 |
| 192 | Fostering Resilience to Psychosocial and HIV Risk in Indian MSM PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: India has the world’s third largest HIV epidemic and men who have sex with men (MSM) are an identified high risk group. MSM in India face unique psychosocial stress underlying the context of HIV risk. To maximize the potential impact of an HIV prevention intervention, the purpose of this study is to test, in a two-arm randomized controlled efficacy trial, a behavioral intervention that addresses both psychosocial / contextual stress and reducing participant’s risk for HIV. |
STEVEN A. SAFREN; | 2015-06-01 |
| 193 | The Place of Imaging and Microbiology in The Diagnosis of Pneumonia in The Elderly: PneumOldCT PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diagnosis of pneumonia in the elderly is difficult because of the poor sensitivity and specificity of clinical signs as well as images from chest radiography (RT). New diagnostic tools such as thoracic low-dose computed tomography (CT), which exposes the patient to a weak dose of irradiation, could improve diagnosis. Moreover, low-dose CT could provide additional accuracy in the etiological clarification of pneumonia in elderly people. As a first step, the investigators aim to perform a 1 year (12 months of inclusion + 3 months of follow-up) prospective study including the Divisions of Internal Medicine, Rehabilitation, … |
VIRGINIE PRENDKI; | 2015-05-01 |
| 194 | A Phase II, Randomized, Multicenter, Dose-Ranging Study in Adult Subjects Evaluating The Efficacy, Safety, and Tolerability of Single Doses of GSK2140944 in The Treatment of Uncomplicated Urogenital Gonorrhea Caused By Neisseria Gonorrhoeae PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: GSK2140944 has demonstrated in vitro activity against Neisseria (N.) gonorrhoeae, including ciprofloxacin resistant and susceptible strains. This study is a Phase II, randomized, multicenter, open-label, dose ranging study designed to inform the optimal oral dose of GSK2140944 by further characterizing the efficacy, safety, … |
GLAXOSMITHKLINE | 2015-04-15 |
| 195 | Asymptomatic Sexually Transmitted Infections (STI) : Comparison of Two Screening Strategies Routine Screening Versus Screening As Reported By The Risks Taken By The Patient, in A Cohort of HIV Outpatients Men Who Have Sex With Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparison of two screening strategies of asymptomatic sexually transmitted infections : routine screening versus screening as reported by the risks taken by the patient, in a cohort of HIV outpatients men who have sex with men. The aim of this study will be create and validate a simple tool for clinicians. A digital tool will be developed will allowed empowerment of HIV-positive men who have sex with men. |
DAVID ZUCMAN; | 2015-04-01 |
| 196 | Effectiveness of A Patient Centered Intervention to Increase Dual Protection Against Unintended Pregnancy and Sexually Transmitted Disease Among Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to use a text messaging intervention to prevent unintended teen pregnancy and transmission of sexually transmitted disease. The study will be informed by a formative qualitative phase (February 2014 – January 2015) which will include individual qualitative interviews and focus groups with teens to elucidate and explore the barriers to effective contraceptive use and sexually transmitted disease (STD) prevention and to obtain feedback on the developed intervention. The second efficacy phase will randomize subjects to the texting intervention or to usual care. |
DEBORAH RINEHART; | 2015-04-01 |
| 197 | Evaluating A Microfinance Intervention for Vulnerable Women in Kazakhstan PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will examine the efficacy of a combined HIV and microfinance intervention to reduce biologically confirmed sexually transmitted infections (STIs), and new incidence of HIV and HCV, as well as reported sexual and drug risk behaviors among 520 women who have injected drugs in the past year and who engage in sex trading in Temirtau and Pavlodar, Kazakhstan. The proposed study builds on findings from an R34 by the investigative team testing a combination HIV prevention and microfinance intervention. Building on successful protocols and significant results, … |
SUSAN WITTE; | 2015-04-01 |
| 198 | Efficacy of A Health Promotion and STI Prevention Program for Entertainment Establishments in Singapore PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators aim to assess the efficacy of a multi-component intervention on condom use and sexually transmitted infection (STIs) in female entertainment workers and men frequenting entertainment establishments (EEs), using a quasi-experimental design. Joo Chiat and Golden Mile Complex will be selected purposively as control cluster sites (n=220) with follow-up of entertainment workers at 6 weeks. The same sites will be used as intervention sites after a 3-months ‘wash out’ period. Self-reported condom use, vaginal swab samples for polymerase chain reaction (PCR) for cervical gonorrhoea and chlamydia infections, … |
WONG MEE LIAN; | 2015-03-01 |
| 199 | Randomized Controlled Trial of Treatment of Male Partners of Women With BV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Male partners of womoen with recurrent bacteria vaginosis are randomized to treatment with metronidazole or placebo to compare the rates of recurrent BV in the women |
JANE SCHWEBKE; | 2015-02-01 |
| 200 | Detection of Chlamydia DNA By Polymerase Chain Reaction ( PCR ) in Tumours Tissue of Primary Tubal and Ovarian Cancers : A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: PCR for chlamydia DNA is done in paraffin blocks of cases of primary tubal cancer and is compared to cases of high grade serous ovarian cancer and normal tubes . |
MOHAMED LABAN; | 2015-01-01 |
| 201 | A Phase 1, Open-Label, Within-Subject Dose-Escalation Study to Evaluate The Clinical Vulvar-Vaginal Safety and Pharmacokinetic Profile of SST-6006, A Topical Sildenafil Cream (5% W/w), in Healthy Postmenopausal Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1, single center, open-label, within-subject dose-escalation study evaluating the safety and pharmacokinetics of SST-6006 in healthy postmenopausal women. Three dose levels of SST-6006 and a placebo regimen will be evaluated: 1 g (0 mg of sildenafil), 1 g (50 mg of sildenafil), 2 g (100 mg of sildenafil), and 4 g (200 mg of sildenafil). Doses will be administered sequentially and will be separated by a 14-16 day washout period. All 3 dose levels and the placebo will be applied both externally and internally. |
KEN LASSSETER; | 2015-01-01 |
| 202 | Silent Intracellular Infections and Early Pregnancy Loss PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Correlation between the presence of intracellular viruses/bacteria and the incidence of miscarriage during the first trimester of pregnancy. |
ANGELA GRAZIANO; | 2014-11-15 |
| 203 | Evaluating Impact of Azithromycin Mass Drug Administrations on All-cause Mortality and Antibiotic Resistance: Morbidity Study PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The long-term goal of this study is to more precisely define the role of mass azithromycin treatments as an intervention for reducing childhood morbidity and increasing growth, and for the potential selection of antibiotic resistance. The investigators propose a set of 3 cluster-randomized trials in Malawi, Niger, and Tanzania comparing communities randomized to oral azithromycin with those randomized to placebo. To assess the generalizability of the intervention, investigators will monitor for antibiotic resistance, … |
TOM M LIETMAN; | 2014-11-01 |
| 204 | Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine, in children hospitalized with pneumonia, if an extended duration of oral antibiotics (10 days) will be superior to a shorter duration (3 days) of antibiotics in improving clinical outcomes. Secondary Aims: 1. Describe the prevalence of respiratory viruses and bacteria at presentation. 2. Investigate the depression, anxiety and stress scores (DASS21) and quality of life scored (QOL) by parents of the children during admission, pre-discharge and post discharge and at follow-ups. |
ANNA MARIE NATHAN; | 2014-11-01 |
| 205 | Unexplained Early Miscarriage : Role and Prevalence of Lower Genital Tract Infections in Rural Area in Egypt PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study group included 910 women who attended Fayoum university hospital gynecology outpatient clinic for postabortive evaluation. The control group included 940 women attended outpatient clinic for any other procedure or complaint |
AHMED MAGED; | 2014-10-01 |
| 206 | Open-label Comparative Safety and Efficacy Study of Levofloxacin and Amoxicillin Clavulanic Acid in Patients With Acute ,Bacterial Rhinosinusitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Inflammatory paranasal diseases are among the most common diseases in ENT In Russia, puncture method has been conventional approach to treatment of maxillary sinusitis. However, this procedure is associated with a number of drawbacks A promising trend for the treatment of purulent sinusitis is a reasonable antibacterial therapy Fluoroquinolones, particularly levofloxacin, are highly active against pneumonocci and are more active vs. the drug products of the second generation against intracellular agents (Chlamydia spp., Mycoplasma spp., M. tuberculosis, rapidly growing atypical mycobacteria (M. avium, … |
A Y OVCHINNIKOV; | 2014-09-01 |
| 207 | Self-Obtained Vaginal Swabs for Chlamydia and Gonorrhea Testing: Concurrence in Non-Clinical Settings Vs. Clinical Settings PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the agreement between NAAT results for Chlamydia trachomatis and Neisseria gonorrhoeae infection obtained with self-obtained vaginal swabs (SOVS), collected in a non-clinical setting vs. NAAT results using SOVS collected in a clinical setting. This is a new use of this specimen type as SOVS are FDA cleared only for use in clinics. The NAAT (Gen-Probe APTIMA Combo 2® Assay (AC2)) result with the home-collected SOVS specimen will be compared to the result obtained with an SOVS collected in the clinic on multiple platforms (Direct Tube Sampling (DTS) / Panther / Tigris). The term home-collected is used to refer to any specimen that is not collected in a clinic, since there is no certainty that a specimen is collected at home or in a restroom in an office setting, etc. To compare the SOVS results to an FDA cleared predicate test with the collection of two clinician collected vaginal swabs. |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO | 2014-08-01 |
| 208 | An Open-Label, Randomized, Multi-Center Study to Evaluate The Efficacy and Safety of A Single Dose of Oral Solithromycin Compared to Single-Dose Intramuscular Ceftriaxone Plus Single-Dose Oral Azithromycin in The Treatment of Male and Female Patients With Uncomplicated Urogenital Gonorrhea With or Without Concomitant Chlamydia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will compare a single dose of oral solithromycin to the standard of care (intramuscular ceftriaxone plus oral azithromycin) in the treatment of patients with urogenital gonorrhea. A completed open-label Phase 2 study with single doses of solithromycin resulted in 100% microbiological eradication in male and female patients with uncomplicated urogenital gonorrhea. |
MARCUS CHEN; | 2014-08-01 |
| 209 | Nepal Elimination of Trachoma Study Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine if ocular Chlamydia trachomatis infection can be eliminated in communities in Nepal following mass antibiotic distributions with azithromycin. The investigators will study both clinical trachoma and ocular C. trachomatis infection. The overall objective is to determine if the current World Health Organization (WHO) treatment strategy results in elimination of trachoma and infection. 1. The investigators hypothesize that 24 communities in Kanchanpur, Kailali, … |
BRUCE D GAYNOR; | 2014-08-01 |
| 210 | Controlled, Multicenter, Randomized Parallel Group Pilot Study With 2 Treatment Arms in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis (BV) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacterial vaginosis (BV) is the most common cause of vaginitis in women of childbearing age. Women with symptomatic BV may present with malodorous discharge that is off-white, thin, and homogenous and has a fishy smell especially after intercourse. It is of importance to treat women with BV, as this condition is associated with serious risks, such as an increased risk of preterm birth in pregnant women, … |
UNIVERSITY HOSPITAL INSELSPITAL BERNE | 2014-06-01 |
| 211 | Back to BASICS: Boric Acid, Alternate Solution for Intravaginal Colonization, Comparing Intravaginal Metronidazole to Boric Acid in Women Symptomatic for Bacterial Vaginosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bacterial vaginosis (BV), the world’s most common vaginal infection, continues to cost patients time, energy, comfort and money. BV is associated with increased incidence of sexually transmitted infections (including HIV), spontaneous abortion, pre-term labour, post-surgical infections, and endometritis. Current treatment for those women symptomatic for BV includes both oral and intravaginal antibiotics, such as metronidazole, … |
KONIA TROUTON; | 2014-04-01 |
| 212 | Limiting HIV Target Cells By Inducing Immune Quiescence in The Female Genital Tract PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this project, the investigators want to analyse the capacity of Acetylsalicylic acid and hydoxychlroquin (HCQ) to induce an Immune Quiescence (IQ) phenotype, which has been previously associated with natural protection to HIV infection. This phenotype is characterized by lower expression of genes involved in cellular activation, lower resting levels of inflammatory cytokine production, lower level of systemic activated T cells, increased levels of systemic T regulatory, … |
KEITH FOWKE; | 2014-04-01 |
| 213 | Effectiveness of Cervical Screening in HPV Vaccinated Women – A Randomized Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to identify whether or not being informed infrequently results about screening is: 1) At least as safe and accurate as frequently obtaining all information from the present combination of opportunistic/organized cervical screening by comparing regimen results of three screening visits at the ages of 22, 25 and 30 years (Arm A1) vs. results of one screening visit at the age of 30 years (Arm A2) in Human papillomavirus (HPV) vaccinated young women. |
MATTI LEHTINEN; | 2014-03-01 |
| 214 | Clinical Study Protocol for The Illumigene® Chlamydia and Illumigene® Gonorrhea DNA Amplification Assays PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the illumigene Chlamydia and illumigene Gonorrhea assays, using the illumipro-10, with male urine, female urine, physician-collected (medical professional) endocervical swabs and self-collected vaginal swabs taken from symptomatic and asymptomatic patient populations. |
MERIDIAN BIOSCIENCE | 2014-03-01 |
| 215 | Mecillinam for Treatment of Genital Chlamydia Infection in Asymptomatic Men PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The mainstay of treating both symptomatic and asymptomatic genital Chlamydia trachomatis infection has been macrolide antibiotics in the form of azithromycin, and alternatively tetracycline antibiotics in the form of doxycycline. Studies from the late nineties found a single dose of 1 g azithromycin to be equally effective as a 7 day course of 200 mg doxycycline a day. However, recent studies have reported increasing treatment failure that may indicate that resistance to macrolide antibiotics among Chlamydia trachomatis is evolving. Research regarding other bacterial species indicates a high frequency of mutation based resistance in conjunction with azithromycin use, … |
ANNE OLAUG OLSEN; | 2014-03-01 |
| 216 | Prevalence of Gonorrhea and Chlamydia Infections in Multiple Anatomical Sites in HIV-infected Men Who Have Sex With Men at An HIV Clinic in Omaha, Nebraska PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypothesis: Men who have sex with men (MSM) are at higher risk for sexually transmitted diseases. Currently, free testing for sexually transmitted diseases is only being performed in urine samples. Investigators hypothesize that the rates of both gonorrhea and chlamydia will be higher when testing includes more than one anatomical site (rectum and oropharynx). The aim of the study is to estimate the rates of asymptomatic Chlamydia and/or Gonorrhea in the oropharynx, … |
URIEL SANDKOVSKY; | 2014-01-01 |
| 217 | A Validation Study of The Cepheid Xpert CT/NG for Detecting Chlamydia Trachomatis and Neisseria Gonorrhoeae in Rectal Samples PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to validate Xpert CT/NG for the detection of CT and GC in rectal samples as part of the PA DOH and CLIA requirements. The evaluation of samples obtained from the pharynx is exploratory and will provide new information on the frequency of pharyngeal infection due to CT and GC. A secondary objective will be to evaluate the prevalence of Trichomonas vaginalis in vaginal and rectal samples using both the Xpert system and AC2 to assess whether women positive for this pathogen rectally usually or always have vaginal infection due to this pathogen. The investigators hypothesis is that real-time PCR (polymerase chain reaction) amplification testing with the Cepheid Xpert CT/NG will have greater sensitivity than culture in detecting Neisseria gonorrhoeae in rectal samples. The investigators also hypothesize that Xpert CT/NG will be equivalent to the Gen-Probe APTIMA Combo2 (AC2) in detecting Chlamydia trachomatis and Neisseria gonorrhoeae in rectal samples. |
SHARON HILLIER; | 2013-12-01 |
| 218 | Erythromycin Versus Amoxicillin for Treatment of Antenatal Chlamydia Trachomatis Infection: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PREGNANT WOMEN IN ANTENATAL CLINIC WILL BE SCREENED FOR CHLAMYDIA TRACHOMATIS INFECTION WITH ENDOCERVICAL SWAB.THOSE THAT TEST POSITIVE AND SATISFY THE INCLUSION CRITERIA WILL BE COUNSELLED AND ENROLLED INTO THE STUDY AFTER OBTAINING INFORMED CONSENT.THE PARTICIPANTS WILL BE RANDOMISED INTO ONE OF THE TWO GROUPS.THE DRUGS WILL BE TAKEN FOR I WEEK AND THE SEXUAL PARTNER(S) WILL ALSO BE TREATED WITH DOXYCYCLINE FOR 1 WEEK. BARRIER CONTRACEPTION WILL ALSO BE USED DURING THE TREATMENT.THE SEXUAL PARTNERS WILL BE CONTACTED THROUGH TELEPHONE CALLS AND THE BENEFITS OF PARTICIPATING IN THE STUDY WILL BE EXPLAINED TO THEM. LATEX MALE CONDOM WILL BE GIVEN TO THE WOMEN. ALSO, FOLLOW-UP TELEPHONE CALLS WILL BE PUT ACROSS TO THEM DURING THE TREATMENT WEEK TO ENHANCE COMPLIANCE. A REPEAT ENDOCERVICAL SWAB WILL BE TAKEN 4 WEEKS AFTER TREATMENT TO CHECK FOR MICROBIOLOGICAL CLEARANCE. A STUDY PROFORMA WILL BE FILLED DURING THIS VISIT. THE DATA WILL BE ANALYSED USING STATISTICAL PACKAGE FOR SOCIAL SCIENCES VERSION 17. |
OKUNOLA TEMITOPE OMOLADUN; | 2013-10-01 |
| 219 | Reducing HIV/STD Risk in African American Women With At-Risk Male Partners PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The FemAALES Project is a community collaborative two-arm intervention designed to prevent HIV (human immunodeficiency) and STD (sexually transmitted disease) infection and transmission among African American women and men by reducing sexual risk factors and enhancing sexual negotiation skills. The team of investigators is a collaboration of researchers and community service providers who are committed to developing prevention interventions that employ holistic and culturally relevant approaches. This includes recognizing the impact of forces such as racism, sexism, and gender expectations on individual behavior and relationship dynamics in African American communities. Specifically, … |
NINA T HARAWA; | 2013-07-01 |
| 220 | Implementation of A Sexual Health Intervention for YMSM in Two Vietnamese Cities PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to implement a sexual health promotion intervention for male sex workers in Hanoi and Ho Chi Minh City, Vietnam. The study hypothesis is that this intervention will increase testing, treatment and vaccination for sexually transmitted infections, including intentions of participants to engage in these services beyond the conclusion of the intervention. At the community level, the study hypothesis is that male sex workers will be more aware of sexual health care and more likely to access these services in the future. |
NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES | 2013-05-01 |
| 221 | Efficacy of Internet-based HIV Prevention PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Young men who have sex with men (YMSM) account for almost 70% of HIV diagnoses among all young people in the U.S. and are alone in facing an increasing rate of infections. Because YMSM are less likely to receive relevant sexual health education in traditional settings (e.g. schools, community), the Internet is a unique route of reaching and helping YMSM. The purpose of this study is to compare two different versions of an online HIV prevention program for YMSM. The study is being conducted by researchers at Northwestern University in Chicago, Hunter College in New York City, … |
BRIAN MUSTANSKI; | 2013-05-01 |
| 222 | The Role of Viral Infection in Acute Exacerbations of Non-cystic Fibrosis Bronchiectasis in Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchiectasis is clinically characterized by irreversible dilation of the bronchi and bronchioles leading to persistent cough, purulent sputum, and airway flow limitation, which may be accompanied by recurrent exacerbations.It has been increasingly recognized that respiratory viruses are mainly responsible for acute exacerbation of chronic pulmonary diseases, i.e. asthma, chronic obstructive pulmonary disease and cystic fibrosis. However,little is known about the roles of viral infection in driving exacerbations of bronchiectasis.This study aims to identify the frequency of common viral infections and determine the roles that viruses play in acute exacerbations of bronchiectasis. |
YONGHUA GAO; | 2013-02-01 |
| 223 | Prospective Collection of Female First-catch Urine, Vaginal Swab,Cervical, and Endocervical Swab Specimens for Testing With The APTIMA Assays PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to obtain female first-catch urine, vaginal, cervical and endocervical swabs for testing with multiple APTIMA Assays on the Gen-Probe PANTHER® and TIGRIS® Systems. |
GEN PROBE | 2013-01-01 |
| 224 | A Trial of Intravesical Therapy for Interstitial Cystitis in Patients With Generalized Vulvodynia Related Papers Related Patents Related Grants Related Experts View Highlight: In order to investigate whether the pain in women with vulvodynia may represent bladder origin pain, we will be performing a diagnostic test for interstitial cystitis (IC) in women with generalized vulvodynia. Those women with a positive test for IC, we will be performing a series of bladder treatments (instillations) for IC and checking symptoms throughout the trial to see if significant relief of vulvar pain can be obtained through treatment for IC. |
BRUCE KAHN; | 2012-12-01 |
| 225 | An Integrated HIV Prevention Model for African American Mothers and Daughters PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study has three specific aims: 1. To conduct a 2-arm randomized controlled trial comparing IMARA to a family-based health program (FUELTM). The investigators will: a. Randomly assign 300 14-18 year-old AA or black girls and their primary female caregivers to IMARA (N=150) or FUELTM (N=150). Women and girls will be recruited four ways: 1) from mental health clinics using clinic liaisons, 2) flyers will be posted in clinic recruitment sites and other agencies instructing interested families to call our recruiter, 3) IMARA participants will hand flyers to interested women and girls they know, … |
GERI DONENBERG; | 2012-11-01 |
| 226 | Transplacental Transfer of Drugs Used in Pregnant Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The most important guideline for drug prescription concerning pregnant women is ‘drugs should be given only if the maternal benefits outweigh the potential risk to the fetus’. However, poor data is available on maternal drug disposition and transfer through the placenta, … |
KRISTEL VAN CALSTEREN; | 2012-11-01 |
| 227 | Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective, Randomised,Placebo-controlled, Double-blind Study Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic bladder pain syndrome is a chronic disabling disorder characterized by chronic pelvic pain, pressure or discomfort perceived to be related to the urinary bladder accompanied by at least one other urinary symptom such as persistent urgency or frequency in the absence of an identifiable cause. Chronic bladder pain syndrome severely decreases an individual’s quality of life and represents a significant financial burden to those affected by it. Currently, multifactorial pathogenesis is assumed including endocrine-involvement, pelvic floor muscle irregularities, immunologic aspects and chemical causes. Corresponding to the wide spectrum of presumptive triggers, a large number of therapeutic approaches are propagated, … |
FIONA BURKHARD; | 2012-11-01 |
| 228 | Expedited Partner Therapy As STI Control Among MSM in Peru PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Expedited Partner Therapy (EPT) has been shown to reduce rates of persistent or recurrent gonorrhea and chlamydia infection in heterosexual patients, but has not been evaluated for use among men who have sex with men (MSM). CDC guidelines support the use of EPT for partner management with heterosexual patients, but note the absence of evidence necessary to make an equivalent recommendation for the use of EPT with MSM. Randomized clinical trials to assess the impact of EPT on partner notification, treatment, … |
JESSE CLARK; | 2012-08-01 |
| 229 | Technology Enhanced Community Health Nursing (TECH-N) to Prevent Recurrent Sexually Transmitted Infections After Pelvic Inflammatory Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are enrolling 350 young women 13-25 years old diagnosed with pelvic inflammatory disease (PID) in Baltimore and randomize them to receive community health nurse (CHN) clinical support using a single post-PID face-to-face clinical evaluation and short messaging system communication support during the 30. The investigators hypothesize that repackaging the recommended Centers for Disease Control and Prevention (CDC) follow-up visit using a technology-enhanced community health nursing intervention (TECH-N) with integration of an evidence-based sexually transmitted infection (STI) prevention curriculum will reduce rates of short-term repeat infection by improving adherence to PID treatment and reducing unprotected intercourse and be more cost-effective compared with outpatient standard of care (and hospitalization). |
MARIA TRENT; | 2012-07-01 |
| 230 | A Phase 2b, Randomized, Double-Blind, Active-Controlled Study to Evaluate The Safety and Efficacy of Rifalazil (25 Milligram) Compared With Azithromycin (1 Gram) for The Treatment of Uncomplicated Genital Chlamydia Trachomatis Infection in Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test the safety and effectiveness of an investigational antibiotic drug, rifalazil for the treatment of uncomplicated genital Chlamydia trachomatis infection. This study will examine the effects of 25 milligram of rifalazil compared with azithromycin 1 gram, which will be given as a single dose to women who have genital chlamydial infection. |
ACTIVBIOTICS PHARMA | 2012-07-01 |
| 231 | Evaluation of Abbott RealTime CT/NG for The Detection of Chlamydia Trachomatis [CT] & Neisseria Gonorrhoeae [NG] From The Pharynx, Rectum & Urethra of Men Who Have Sex With Men [MSM] PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Julius Schachter, PhD, (Department of Laboratory Medicine, University of California, San Francisco) and Susan S. Philip, MD MPH (Department of Medicine, University of California, San Francisco) are conducting a study to evaluate the Abbott RealTime CT/NG polymerase chain reaction [PCR] assay (which is a nucleic acid amplification test [NAAT]) for detecting two sexually transmitted bacteria, Chlamydia trachomatis [CT] and Neisseria gonorrhoeae [NG], using urine samples and swabs from the throat and rectum of men who have sex with men [MSM]. Using this test on these swabs is experimental because it has not been approved by the Food & Drug Administration. |
JULIUS SCHACHTER; | 2012-06-01 |
| 232 | Repeat STI Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: People who present repeatedly at Sexually Transmitted Infection (STI) clinics represent a key population for HIV prevention intervention research. Despite their heightened risk there is an absence of empirical research on strategies to intervene with repeat STI. Some STI-clinic based behavioral HIV prevention studies, focusing on the general STI patient population, have found that risk reduction interventions can reduce the incidence of a subsequent STI. Studies have shown that expedited treatment for STI patients’ partners can reduce subsequent STI and enhancing partner notification can reduce risk for repeat infection. Those who go on to experience repeat infections, … |
LANCE WEINHARDT; | 2012-04-01 |
| 233 | HIV Prevention Intervention for Young Transgender Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test the efficacy of a uniquely targeted HIV risk reduction intervention for young transgender women (YTW), ages 16 to 29, at risk for HIV acquisition or transmission. |
ROBERT GAROFALO; | 2012-03-01 |
| 234 | Prospective Collection of Female First-catch Urine, Vaginal Swab, Cervical, and Endocervical Swab Specimens and Male Urethral Swab and First-catch Urine Specimens for Testing With The PANTHER® System PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to obtain female first-catch urine, vaginal, cervical and endocervical swabs and male first-catch urine and urethral swabs for testing with multiple APTIMA Assays on the Gen-Probe PANTHER® System |
GEN PROBE | 2012-02-01 |
| 235 | EKISS Electronic KIOSK Intervention for Safer-Sex: A Pilot Randomized Controlled Trial of An Interactive Computer-based Intervention for Sexual Health in Adolescents and Young Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized controlled trial to test acceptability, feasibility and preliminary efficacy of an interactive computer-based intervention with individualized feedback to promote sexual health in adolescents and young adults with assessment of behavioral and biomarker outcomes. |
TARANEH SHAFII; | 2012-02-01 |
| 236 | A Prospective, Double-masked, Placebo Controlled Comparison of Topical 0.15% Ganciclovir Gel (Zirgan®) Versus 0.3% Hypromellose Gel (Genteal Gel®; Placebo) for The Treatment of Adenovirus Conjunctivitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are conducting this study because the patient have an eye infection which is called adenoviral conjunctivitis, and is the most common cause of pink eye. There is currently no treatment for this condition. However, the researchers associated with this study want to understand if using a product called Zirgan, which is a topical ointment that is already FDA-approved for other types of eye infections, … |
PARAG A MAJMUDAR; | 2012-01-01 |
| 237 | Project AWARE: Using The ED to Prevent STIs in Youth Related Papers Related Patents Related Grants Related Experts View Highlight: Project Aware introduces a sexually transmitted infection (STI) screening model for sexually experienced adolescents aged 14 to 21 in a large, inner-city Emergency Department (ED) in the Bronx, N.Y. Project Aware will scaffold routine, rapid testing and counseling for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) onto an existing, successful, ED-based HIV testing and counseling program, Project BRIEF. Project Aware will educate and motivate youth to use condoms with the aid of a theory-based, youth-friendly multimedia behavioral intervention proven to be effective during the investigator’s K23 training. Through Project Aware, … |
YVETTE CALDERON; | 2011-12-01 |
| 238 | Reducing The Risk of HIV/STD Infection Among African American Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: African American men have by far the highest rates of HIV in the US, but there are few randomized controlled trials (RCTs) of interventions to dissuade heterosexually active African American men from engaging sexual risk behavior. This research seeks to address this gap in the behavioral intervention literature. That self-initiated behavior change, as well as intervention-induced behavior change, is often short-lived, eroding over time, is widely known; accordingly, this research also seeks to test a strategy to sustain intervention efficacy. In a RCT, … |
JOHN B JEMMOTT III; | 2011-10-01 |
| 239 | Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to see if a computerized counseling tool helps patients reduce their sexual transmission risk and improve their antiretroviral adherence. |
ANN KURTH; | 2011-09-01 |
| 240 | Assessing A Medicaid Randomized Insurance Experiment Within Community Clinics PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This study examines the impact of a randomized insurance experiment on preventive services receipt and healthcare utilization in safety net patients using linked public insurance claims and safety net clinics’ electronic health record (EHR) data. |
JENNIFER E DEVOE; | 2011-08-01 |
| 241 | Sexually Transmitted Infections Among African American Women Who Have Sex With Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine rates of sexually transmitted infections (STIs) among African American women who have sex with women (AAWSW). In addition, the study is interested in better understanding the types of risk behaviors that place AAWSW at risk for STIs. The investigators hypothesis is that AAWSW experience high rates of STIs, similar to heterosexual African American women. Knowledge gained from this study will guide development of interventions to reduce women’s risk for these types of infections and will improve how AAWSW are screened for STIs. |
CHRISTINA MUZNY; | 2011-08-01 |
| 242 | Women With Epilepsy: A Pilot Study of Pharmacokinetic and Pharmacodynamic Anti-epileptic Drug Effects in Levonorgestrel Intrauterine System Users PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will conduct a prospective, seven-month pilot study to explore pharmacokinetic (PK) and pharmacodynamic (PD) effects among women with epilepsy using the levonorgestrel intrauterine system (LNG IUS) for contraception. The investigators will enroll twenty women with well-controlled epilepsy maintained on stable anti-epileptic drugs (AED) therapy seeking the LNG IUS for contraception. The primary outcomes are AED levels and seizures before and after LNG IUS placement. Secondary outcomes include LNG levels, evidence of ovulation three weeks after insertion (serum progesterone >3ng/ml), bleeding and spotting, endometrial thickness, continuation, satisfaction and adverse events (removals, expulsions, … |
ANNE DAVIS; | 2011-08-01 |
| 243 | AMC-072: Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex With Males PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: RATIONALE: Vaccines made from a gene-modified virus may help the body build an effective immune response to prevent viral infection. PURPOSE: This phase II trial is studying how well vaccine therapy works in preventing human papillomavirus (HPV) infection in young HIV-positive male patients who have sex with males. |
JOEL PALEFSKY; | 2011-06-28 |
| 244 | A Case Control Study of Women With Multiple Sexual Partners Attending The Jefferson County Department of Health Sexually Transmitted Diseases Clinic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Both population based surveys and more focused research studies indicate that increased numbers of sexual partners and partner concurrency contribute to increased risk for acquisition of sexually transmitted infection (STI), including HIV infection. However, unlike for men, both national and sub-population-based studies consistently find that the great majority of women with or without STIs report only 1-2 sex partners in the preceding year and that a minority of women acknowledge > 3 sex partners over the same period, … |
CHRISTINA MUZNY; | 2011-05-01 |
| 245 | The Use of Computer-Assisted Self-Interviews to Improve Adolescent and Young Adult Health Screening in The Pediatric Emergency Department PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if an Audio-enhanced Computer-Assisted Self-Interview (ACASI) will lead to increase testing for sexually transmitted infections in youth visiting a pediatric ED |
FAHD A AHMAD; | 2011-04-01 |
| 246 | A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of The Dominican Republic (DR) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the feasibility of introducing voluntary medical male circumcision as a form of HIV prevention in high HIV prevalence areas in the Dominican Republic. |
MAXIMO BRITO; | 2011-02-01 |
| 247 | Safer Sex Intervention for Male Clients of Female Sex Workers in Tijuana, Mexico PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Behavioral interventions designed to reduce risk of HIV and sexually transmitted infections (STIs) have mostly failed to consider clients of female sex workers (FSWs), who may act as a bridge to the general population. This study proposes to test a brief, one-hour counseling intervention with male clients in Tijuana, Mexico, to reduce their rates of unprotected sex (i.e., … |
THOMAS L. PATTERSON; | 2011-01-01 |
| 248 | Chlamydia Trachomatis Immunology and Vaccinology Study: Determination of Protective T Cell Responses to Chlamydia Trachomatis Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective is to prospectively follow 200 women with or at risk of cervicitis to determine the chlamydia-specific cellular responses that correlate with protection against incident infection. The hypothesis is that a positive IFN-y response by peripheral CD4+ T cells responding to stimulation with HSP60 will be significantly associated with protection from incident C. trachomatis infection. |
HAROLD WIESENFELD; | 2011-01-01 |
| 249 | Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells Injection for Diabetic Foot PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for diabetic foot is safe and effective in the management of diabetic foot ischemia, the therapeutic effect of stem cells is caused by improving blood circulation in ischemic limb which would in turn promote ulcer healing, prevent amputation of limb and relieve the Sevier pain of ischemia. |
YANGANG WANG; | 2011-01-01 |
| 250 | A Double-Blind, Randomised, Placebo-Controlled Phase I Trial to Compare The Pharmacokinetics of Maraviroc and Dapivirine Following Application of Maraviroc Vaginal Vaginal Gel, 0.1% 2.5g, Dapivirine Vaginal Gel, 0.05%, 2.5g and Maraviroc 0.1% + Dapivirine 0.05% Vaginal Gel, 2.5g Formulations, and to Assess Their Safety As Compared to The Matching Placebo Vaginal Gel, 2.5g in Healthy, HIV-Negative Women Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the pharmacokinetics of the combination dapivirine and maraviroc gel and determine whether it is safe for daily use by healthy women in the United Kingdom |
INTERNATIONAL PARTNERSHIP FOR MICROBICIDES | 2011-01-01 |
| 251 | The Role of Respiratory Viruses in Exacerbations of Cystic Fibrosis in Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Respiratory viruses, such as those that cause colds and influenza, are very common in the general population. The average adult will experience between 2 and 4 viral respiratory illnesses each year. It is known that respiratory viruses can cause flare-ups of chronic lung diseases such as asthma and chronic obstructive pulmonary disease. In children with CF, respiratory viral infections have been identified in nearly half of all exacerbations and are associated with a decline in lung function and increased frequency of hospital admission and acquisition of new bacterial pathogens. Currently, … |
WILLIAM G FLIGHT; | 2010-12-01 |
| 252 | Clinical Evaluation of The APTIMA® Assay for Chlamydia Trachomatis Using The PANTHER™ System Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this multi-center clinical study is to demonstrate that the APTIMA(R) Assay for Chlamydia trachomatis (CT; ACT Assay), which is cleared for use on the TIGRIS DTS (Direct Transfer) System (TIGRIS System), can be tested on the PANTHER System. The intended use of the ACT Assay will be unchanged except for the inclusion of its use with the PANTHER System. ACT Assay performance on the PANTHER System is comparable to performance on the TIGRIS System. |
GEN PROBE | 2010-11-01 |
| 253 | Human Papillomavirus (HPV) Infection in Young Men Who Have Sex With Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Studies indicate that men who have sex with men (MSM) have a high prevalence of anogenital Human papillomavirus (HPV) infection and increased risk for HPV related anogenital lesions including anogenital warts, anal intraepithelial neoplasia (the abnormal proliferation of cells) and anal cancer. Currently in Australia, HPV vaccine for men is not covered by programs. This study will explore the prevalence of HPV infection and sexual behaviours associated with varying prevalence of HPV infection. The investigators will survey 200 MSM aged 16-20 years who just started their sexual life. The investigators will use a questionnaire to collect information of socio-demographic characteristics, … |
CHRISTOPHER FAIRLEY; | 2010-09-01 |
| 254 | Effect of Lycopene and Isoflavones on Glucose Metabolism Related Papers Related Patents Related Grants Related Experts View Highlight: Type 2 diabetes mellitus (DM2) is a growing social health problem world-wide, in particular with respect to its contribution to cardiovascular disease. The progressive increase in prevalence of DM2 has reached epidemic proportion and is a major cause of morbidity and mortality in all populations around the world. Conventional stepwise treatment of DM2 generally focuses on controlling blood glucose concentration. However, the risk for side-effects associated with the use of pharmacological intervention often delays initiation of therapy, with the potential implication on worsening morbidity and mortality from complications. On the other hand, non-pharmacological intervention in the form of dietary restrictions, … |
NICOLA ABATE; | 2010-09-01 |
| 255 | Maternal Genitourinary Infections and Adverse Perinatal Outcomes in Sylhet District, Bangladesh PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this study is to determine the impact of community-based screening and treatment of abnormal vaginal flora and urinary tract infections in early pregnancy (13-19 weeks) on preterm live birth in Sylhet district, Bangladesh. Hypothesis 1: Community-based screening and treatment of abnormal vaginal flora (Nugent score >4) and urinary tract infections in early pregnancy (13-19 weeks) will reduce the population rate of preterm live birth by at least 15%. The secondary aims of this study are: – To determine the impact of community-based screening and treatment of abnormal vaginal flora and urinary tract infections on the: – … |
ABDULLAH H BAQUI; | 2010-08-01 |
| 256 | Alcohol, Marijuana, and Risky Sex: Group Interventions With Detained Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research is studying behaviors that young people engage in that may place them at risk for contracting a sexually transmitted disease like HIV/AIDS, and what kind of educational program works best to reduce these risky behaviors. |
UNIVERSITY OF NEW MEXICO | 2010-08-01 |
| 257 | Vaginal Cytokines in Postmenopausal Women With Symptoms of Vulvovaginal Irritation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many postmenopausal women suffer from vaginal symptoms such as dryness, itching, and painful intercourse. The underlying pathology is unknown. Since symptoms are comparable to those found in infectious vaginitis during the reproductive life stage, the investigators hypothesize that the vaginal milieu in symptomatic postmenopausal women is comparable to inflammation in vaginitis. The investigators therefore study vaginal cytokines in symptomatic and asymptomatic postmenopausal women. |
PETRA STUTE; | 2010-08-01 |
| 258 | A Randomized Controlled Clinical Trial of An Internet-based Prevention Intervention to Reduce STI in High-risk HIV Infected MSM PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a CCTG sponsored trial in collaboration with UCSD-AVRC investigators to get more information about the methods that are used on the internet to provide information on how to reduce the risk of giving or getting infections that are often or usually passed from one person to another during sexual or intimate contact (sexually transmitted infection (STI)). STIs include chlamydia, … |
SHELDON MORRIS; | 2010-07-09 |
| 259 | PHAT Life: Preventing HIV/AIDS Among Teens in Juvenile Justice PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PHAT Life: Preventing HIV/AIDS Among Teens, is a uniquely-tailored intervention designed for recently-arrested juvenile offenders on probation. The program will teach teens about HIV/AIDS, sexually transmitted infections, and safer decision-making. The PHAT Life Research Study is a 2-arm randomized controlled trial of the PHAT Life Intervention. The investigators will test and compare PHAT Life to the health promotion control group on adolescent risky sexual behavior, substance use, and theoretical mediators. |
GERI DONENBERG; | 2010-06-15 |
| 260 | Project Aware: HIV Rapid Testing & Counseling in STD Clinics in The U.S. — An Adaptation of CTN 0032 PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Project Aware is a randomized controlled clinical trial in which individuals seeking medical or health services at sexually transmitted disease (STD) clinics are recruited to participate in a multi-center HIV testing and counseling study. The investigators will assess the relative effectiveness and cost-effectiveness of (1) on-site HIV rapid testing with brief, participant-tailored prevention counseling vs. (2) on-site HIV rapid testing with information only. The investigators will evaluate the effect of counseling on one primary outcome: STI incidence. Secondary outcomes will be reduction of sexual risk behaviors, substance use during sex (i.e., … |
LISA METSCH; | 2010-04-01 |
| 261 | Safety and Efficacy of WC2031 Versus Vibramycin for The Treatment of Uncomplicated Urogenital Chlamydia Trachomatis Infection: A Randomized, Double-blind, Double-dummy, Active-controlled, Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the clinical efficacy and safety of WC2031 200 mg tablets taken orally once a day for 7 days versus Vibramycin (doxycycline) 100 mg capsules taken orally twice a day for 7 days, for the treatment of uncomplicated urogenital Chlamydia trachomatis infection. Primary efficacy endpoint is microbiological cure at Day 28. Safety assessments are adverse events, changes in vital signs and laboratory test results. |
WARNER CHILCOTT | 2010-04-01 |
| 262 | A Double-Blind, Randomised, Placebo-Controlled Pharmacokinetic and Safety Trial in Healthy HIV-Negative Women to Assess The Delivery of Dapivirine From A Matrix Vaginal Ring and to Evaluate The Safety of A Matrix Vaginal Ring Containing 25 MG of Dapivirine PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study is a single-center, double-blind, randomised, placebo-controlled trial to evaluate the delivery of dapivirine from matrix vaginal rings over a 56 and 57 day period and to assess the safety as compared to placebo vaginal rings in 48 healthy, HIV-negative, sexually active women. |
INTERNATIONAL PARTNERSHIP FOR MICROBICIDES | 2010-04-01 |
| 263 | Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this on-going study is to study the number of days after antibiotic treatment has commenced (due to infection caused by the sexually transmitted bacteria Chlamydia trachomatis (CT) and Mycoplasma genitalium(Mg)) it takes to be cured i.e to get a negative test result. The specimens are analyzed on first-catch-urine (men) or patient’s self-obtained vaginal sample with quantitive nucleic acid amplification test(NAAT). A secondary aim is to detect macrolide resistant Mg-strains and study whether there are any emerging macrolide resistant Mg-strains after treatment with azithromycin. A third aim is to study whether the participating subjects are adherent to the study protocol meaning 12 samples taken during a period of four weeks. |
LARS FALK; | 2010-02-01 |
| 264 | Addressing Psychosocial Needs and HIV Risk in Indian MSM PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will develop and pilot test a combined individual and group-level behavioral HIV prevention intervention for men who have sex with men (MSM) in Chennai, India, addressing HIV risk within the context of broader psychosocial issues, including self-acceptance, substance use and social support. |
STEVEN A. SAFREN; | 2010-01-01 |
| 265 | Randomized Clinical Trial Evaluating Treatment Failure Following Recommended Therapy (Azithromycin Versus Doxycycline) for Genital Chlamydial Infection in Males and Females in Youth Correctional Facilities PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Chlamydia is a common infection among youth and can be given from one person to another during sex. Many people who have chlamydia have no signs of infection at all, but can pass the infection to anyone they have sex with. If not treated, chlamydia can lead to serious health problems. This study will look at how well medicines given for chlamydia infection work. The study requires 306 evaluable subjects, chlamydia-positive, males and non-pregnant females, ages 12-21, living in long-term, gender-segregated youth correctional facilities. Participants will be assigned to receive either doxycycline (2 times per day, by mouth, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2009-12-01 |
| 266 | Antigen-specific Cell Mediated Immune Response to Chlamydia Trachomatis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an exploratory study in which the investigators will develop a way to identify the cell responses most strongly associated with protection against chlamydia infection. This study is not driven by a hypothesis. |
THOMAS L CHERPES; | 2009-12-01 |
| 267 | A Double-Blind, Randomised, Placebo-Controlled Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess Delivery of Dapivirine From The Matrix Vaginal Ring Containing 25 MG of Dapivirine PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study is a single center, double-blind placebo-controlled trial to assess the safety and tolerability of the dapivirine ring as compared to a placebo ring when inserted for 28 days in 16 healthy, HIV-negative women. |
INTERNATIONAL PARTNERSHIP FOR MICROBICIDES | 2009-08-01 |
| 268 | Time to Cure Chlamydia Trachomatis: Prospective Cohort Study on Detection of Chlamydial RNA and DNA in Anorectal and Cervicovaginal Infections During 8 Weeks After Directly Observed Treatment With Azithromycin PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective was to understand the dynamics of Chlamydia trachomatis (Ct) detection by nucleic acid amplification testing (NAAT) after treatment and consequences for test-of-cure practice. |
MAASTRICHT UNIVERSITY MEDICAL CENTER | 2009-06-01 |
| 269 | Frequency, Pathogen Spectrum and Specific Immune Response in Acute Pharyngotonsillitis in Children and Adolescents PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute pharyngotonsillitis is one of the most common infections encountered by pediatricians. Most children with acute pharyngotonsillitis have symptoms that can be attributed to viral infection. However 30-40% of cases is of bacterial etiology. The purpose of this study is to examine frequency, age distribution, clinical picture and pathogen distribution in acute pharyngotonsillitis in children in a large urban setting. |
STEFAN ZIELEN; | 2009-05-01 |
| 270 | A Validation Study of The Gen-Probe APTIMA Combo2 (AC2) for Detecting Chlamydia Trachomatis and Neisseria Gonorrhoeae in Rectal Samples PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Our hypothesis is that nucleic acid amplification testing (NAAT) with the APTIMA Combo2 (AC2) will have greater sensitivity than culture in detecting Neisseria gonorrhoeae in rectal samples. We also hypothesize that AC2 will be equivalent to NAAT with the Becton Dickinson ProbeTec in detecting Chlamydia trachomatis and Neisseria gonorrhoeae in rectal samples. |
SHARON HILLIER; | 2009-05-01 |
| 271 | Prevalence of Asymptomatic and Symptomatic Infection of N. Gonorrheae and C. Trachomatis and Seroprevalence of HSV Typ 2 and Sexual Health Seeking Behaviour in People With HIV Infection in Bern PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There has been an increase in incidence in sexually transmitted infections in HIV infected patients in the last years. In this study the investigators will prospectively evaluate the prevalence of symptomatic and asymptomatic infections with N. gonorrhea and Ch. trachomatis as well as the seroprevalence of Herpes simplex Type 2 infection in HIV-infected patients attending the clinic for infectious diseases at the Berne University Hospital. In addition, participants will be asked to fill out a questionnaire on sexual behaviour and sexual health. Study hypothesis: STI prevalence is high in certain risk-groups to justify screening in regular intervals. |
HANSJAKOB FURRER; | 2009-05-01 |
| 272 | Adapting Project SAFE: Reducing STD/HIV Risk in Women Prisoners PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Project POWER will test the efficacy of a multi-session HIV Prevention program, adapted from an existing program (Project SAFE), for incarcerated women in the rural South. |
CATHERINE FOGEL; | 2009-03-01 |
| 273 | Colonization of The Female Urethra With Mycoplasma Hominis, Ureaplasma Urealyticum, Chlamydia Trachomatis, or Neisseria Gonorrhea in Patients With Lower Urinary Tract Symptoms PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the prevalence of mycoplasma hominis, ureaplasma urealyticum, neisseria gonorrhea, and chlamydia trachomatis in women with overactive bladder symptoms, and to correlate these findings with cystoscopic and urodynamic findings. |
DAVID AMOS SCHEINER; | 2009-01-01 |
| 274 | Biobehavioral Interventions for HIV-negative Methamphetamine-using MSM PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to decrease methamphetamine use and concomitant high-risk sexual behaviors among methamphetamine-using men who have sex with men (MSM) by combining a biomedical intervention with a behavioral intervention. The behavioral intervention will consist of an 8-week course of contingency management (CM) through which participants will be reinforced for testing negative for methamphetamine metabolites during periodic urine analyses. The biomedical intervention involves a 28-day course of an antiretroviral drug (Truvada) to be administered after an unanticipated HIV risk exposure (i.e., … |
CATHY J REBACK; | 2009-01-01 |
| 275 | Assessment of The Vaginal Residence Time of Biomarkers of Semen Exposure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the vaginal residence time of certain semen biomarkers. |
ROXANNE JAMSHIDI; | 2008-12-01 |
| 276 | Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The impetus for this study came from the findings of the investigators’ recently published study entitled Day-care management of severe and very severe pneumonia, without associated co-morbidities such as severe malnutrition, in an urban health clinic in Dhaka, Bangladesh. If day-care management is found to have comparable efficacy to that of hospital management of severe and very severe pneumonia in children then they could be managed at outpatient, … |
INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH | 2008-11-01 |
| 277 | IMARA, Adapting SiHLE for Detained African American Adolescent Females PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The IMARA Program will test the efficacy of a multi-session HIV Prevention program, adapted from an existing program(SiHLE), for incarcerated African American adolescent females. |
RALPH J. DICLEMENTE; | 2008-10-01 |
| 278 | Home Screening for Bacterial Vaginosis to Prevent STDs PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether regular screening (every 2 months) and treatment for bacterial vaginosis (BV [infection of the vagina]) will reduce the number of incidences of chlamydia and gonorrhea (sexually transmitted diseases) over the course of a year. Chlamydial and gonococcal infections will be determined by vaginal swab testing at 4, 8, and 12 months after enrollment. Subjects will include 1500 women aged 15-25 years who have clinical evidence of BV, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2008-07-28 |
| 279 | Integrating Prenatal Care to Reduce HIV/STDs Among Teens: A Translational Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effectiveness of CenteringPregnancy Plus, a group prenatal care treatment program with an HIV/sexually transmitted disease prevention component, in reducing health risk behaviors in pregnant teenagers seeking services at Community Health Centers in the New York metropolitan area. |
JEANNETTE R. ICKOVICS; | 2008-06-01 |
| 280 | Efficacy of HIV Posttest Support for ANC in South Africa PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled intervention trial with 1,500 pregnant and postpartum women to examine the efficacy of an enhanced model of ongoing post-test support for women attending antenatal and postnatal care in KwaZulu-Natal, South Africa. Through the intervention, the investigators will tailor voluntary counseling and testing (VCT) for HIV to the ANC setting and provide a continuum of psychosocial support for pregnant women through: (1) a standardized health education video before HIV pre-test counseling; (2) HIV pre- and post-test counseling sessions that prepare women for decisions related to testing, … |
SUZANNE MAMAN; | 2008-05-01 |
| 281 | Couples Based HIV/STI Prevention for Injecting Drug Users in Kazakhstan PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study addresses a significant public health threat of HIV, HCV and other STIs among a very high risk population of active IDUs and their sexual partners in Kazakhstan a region that is experiencing one of the fastest rising HIV epidemics in the world. There is a race to develop and implement effective HIV preventive interventions for IDUs and their sexual partners to stem the spread of HIV, HCV and other STIs in Almaty, … |
NABILA EL-BASSEL; | 2008-05-01 |
| 282 | An Open Label Study to Evaluate Cycle Control With Ortho Tri-Cyclen Lo (Norgestimate/Ethinyl Estradiol) and Yaz (Drospirenone/Ethinyl Estradiol) in Healthy Sexually Active Females PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study in healthy sexually active females is to evaluate the cycle control with norgestimate/ethinyl estradiol versus drospirenone/ethinyl estradiol. |
ORTHO MCNEIL JANSSEN SCIENTIFIC AFFAIRS | 2008-05-01 |
| 283 | Research to Programs for Trachoma Elimination: Antibiotic Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Trachoma, an ocular infection caused by C. trachomatis, is the second leading infectious cause of blindness worldwide. Years of repeated infection with C. trachomatis cause the eyelid to scar and contract and ultimately to rotate inward such that the eyelashes rub against the eyeball and abrade the cornea (trichiasis). The World Health Organization (WHO) has endorsed a multi-faceted strategy to combat trachoma, which includes the use of antibiotic treatment to reduce the community pool of infection with C. trachomatis. The objective of this study is to conduct a randomized, community-based trial in three countries (Niger, Tanzania and The Gambia), … |
SHEILA WEST; | 2008-05-01 |
| 284 | A Randomized, Single Blinded, Open-Label Crossover-Study of The Possible Induction of Oxidative Stress By Clarithromycin in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to examine whether Klacid® (Clarithromycin) will induce oxidative stress (stress from oxygen) in healthy subjects. This is done by measuring the content of a particular substance in the urine sample, which is released when the body is exposed to oxidative stress. In addition, there will also be taken blood samples, which is analysed for another substance that is indicative of oxidative stress. |
HENRIK E POULSEN; | 2008-05-01 |
| 285 | Help Us, Save Us! HIV/STI Risk Reduction for Black Men Who Have Sex With Men PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The incidence of HIV/AIDS among African American men who have sex with men (MSM) is alarming, and the public health response to this urgent situation has been hampered by a lack of sexual risk reduction interventions with solid evidence of efficacy in this population. Accordingly, the broad, long-term objective of the proposed research is to identify interventions to reduce the risk of sexually transmitted infection (STI) among African American MSM. This application seeks funds to develop and test the efficacy of a theory-based, … |
JOHN B JEMMOTT III; | 2008-04-01 |
| 286 | A Pilot Study of Copper T380A IUDs Versus Oral Levonorgestrel for Emergency Contraception PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to see if women presenting for emergency contraception (EC) are willing to accept the copper intrauterine device (IUD). This study will also compare the use of effective methods of contraception between women who selected the copper IUD or Plan B 6 months after they received EC. |
DAVID TUROK; | 2008-04-01 |
| 287 | Immunopathogenesis of Chlamydia Trachomatis Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sexually transmitted Chlamydia trachomatis infections are a widespread public health concern due to their prevalence and potentially devastating reproductive consequences, including pelvic inflammatory disease, infertility, and ectopic pregnancy. The goal of this study is to evaluate the risk factors for adverse outcomes following genital tract infection with Chlamydia trachomatis and to evaluate whether or not the presence of C. trachomatis in the rectum act as a reservoir for infection. |
AMY M SCURLOCK; | 2008-01-01 |
| 288 | Identification of Bacterial Species and Their Antibiotic-Resistant Spectrum in Sputum Specimen From The Patients With Pneumonia Via Nuclear Acid Detection Assay PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumonia is a common cause of morbidity and mortality. The diagnosis of pneumonia from the microbiology perspective has been challenging. Recent reports suggest the utility of nuclear acid detection for rapid and accurate diagnoses of these pathogens and their antibiotic-resistant spectrum. Extracted bacterial nucleic acid in sputum specimen will be identified by Nuclear acid detection assay kit with Microfluidic Pumping Chip and LAMP methods |
ZHANCHENG GAO; | 2007-12-01 |
| 289 | Leveraging Technology As A Clinician Extender to Screen Culturally Diverse Young Women for Chlamydia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to conduct a quality improvement intervention to improve the ability of health care providers to deliver an important preventive health service (CT screening) in order to meet the goal of universal CT screening for young women age 25 or younger as recommended by the CDC and virtually all major health organizations. This novel approach utilizes a bilingual (English-Spanish) computer kiosk module to deliver education about CT and allow patients to request a CT screening test. This module should significantly increase CT screening among at risk women (18-25yo) attending urgent care clinics and emergency departments. |
MARY-ANN SHAFER; | 2007-09-01 |
| 290 | The Effect of Oral Azithromycin in The Treatment of Chlamydial Conjunctivitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chlamydia trachomatis is one of the major causes of sexually transmitted disease and also the leading infectious cause of blindness in the world.Treatment of C. trachomatis eye infection has involved for a long time. The efficacy of single dose azithromycin has already been demonstrated as effective in the treatment of both trachoma and adult inclusion conjunctivitis.However, in our clinical experience, some patients of chlamydial conjunctivitis may require augmented single dose azithromycin treatments before C. trachomatis is eradicated. In this way, … |
YAN-MING CHEN; | 2007-09-01 |
| 291 | The Contraceptive Choice Project PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this project is to remove barriers to obtaining contraceptive methods, including the most effective and expensive methods. The study seeks to remove the financial and knowledge barriers and promote the most effective contraceptive methods to reduce unintended pregnancy rates at the population level. |
JEFFREY PEIPERT; | 2007-08-01 |
| 292 | A Prospective Single Arm Trial of Involved Field Radiotherapy Alone for Stage I-II Low Grade Non-gastric Marginal Zone Lymphoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective study will test the following hypotheses in patients with stage I-II low grade marginal zone (MZ) lymphoma: – Involved Field Radiotherapy will produce a complete response rate of > 90% – Radiotherapy will be associated with a locoregional progression of < 20% after 10 years - Death from MZ lymphoma will occur in < 40% of patients within 10 years of radiotherapy This study secondary objectives are: - To collect information on the prevalence of H. pylori in non-gastric MALT lymphoma - To estimate rates of acute and late toxicity of radiotherapy |
TRANS TASMAN RADIATION ONCOLOGY GROUP | 2007-07-08 |
| 293 | A Community-level RCT of Expedited Partner Treatment for Gonorrhea and Chlamydia PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The Washington State Community Expedited Partner Therapy Trial is a stepped-wedge community level randomized trial designed to test the hypothesis that a public health program designed to increase the use of expedited partner therapy can decrease the prevalence of chlamydial infection in young women and the incidence of gonorrhea in Washington state. The study intervention will be modeled after and intervention previously evaluated in King County WA (Golden MR, Sex Transm Dis 2007;598-603). The intervention has two components: 1) promotion of patient delivered partner therapy (PDPT) use by medical providers in accordance with Washington state guidelines; … |
MATTHEW GOLDEN; | 2007-07-01 |
| 294 | Chemoprophylaxis for HIV Prevention in Men PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether daily use of emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) can prevent HIV infection in men who also receive HIV counseling, condoms, and treatment for other sexually transmitted infections (STIs). |
ROBERT M. GRANT; | 2007-06-01 |
| 295 | Project Ai Shi Zi: Integrating HIV/STI Prevention and Treatment in China PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effectiveness of a physician training program, the Ai Shi Zi program, in improving HIV/sexually transmitted infection diagnosis, treatment, and management by Chinese physicians and in reducing the number of subsequent infections in their patients. |
THOMAS J. COATES; | 2007-04-01 |
| 296 | Management of Vaginal Complaints: A Pilot Study Within A Practice-Based Research Network PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many women present in primary care with vaginal complaints. The best way of managing these complaints is unclear. This trial will test two different methods of managing patients with vaginal complaints. This is a pilot trial. |
MATTHEW R. ANDERSON; | 2007-02-01 |
| 297 | Extended Antimicrobial Treatment of Bacterial Vaginosis Combined With Human Lactobacilli to Find The Best Treatment and Minimize The Risk of Relapses PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objectives of this study were to characterize lactobacilli of human vaginal origin and to investigate if more extended antibiotic treatment against Bacterial Vaginosis, together with adjuvant lactobacilli treatment, could increase the cure rate and furthermore, to investigate factors that could influence relapse. |
PER-GORAN LARSSON; | 2007-01-01 |
| 298 | Detection and Treatment Benefit of Microorganism (Chlamydia Trachomatis, Mycoplasma Hominis, Ureaplasma Urealyticum) in Overactive Bladder Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this prospective study is to determine the incidence of mycoplasma in women with overactive bladder (OAB) symptoms and whether antibiotic therapy targeting these organisms is effective. |
KYU-SUNG LEE; | 2007-01-01 |
| 299 | An Expanded Phase I Randomized Placebo Controlled Trial of The Safety and Tolerability of 3 Percent W/w SPL7013 Gel (VivaGel™) in Healthy Young Women When Administered Twice Daily for 14 Days PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test the safety and tolerability of a medication applied vaginally twice daily in females versus placebo (inactive substance). Study participants will include 60 women, ages 18-24, non-pregnant, previously sexually active, Human Immunodeficiency Virus (HIV) negative and sexually transmitted infection (STI) free, in San Francisco or Kisuma, Kenya. Each study participant will be followed for 14 days of product use and an additional 7 days for safety assessments. Study procedures will include a physical exam with a pap smear, urine testing, blood sample testing, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2006-12-01 |
| 300 | Home-sampling As A Tool in A Chlamydia Trachomatis Partner Notification Context. A Multi-centre Cluster-randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Though partner notification is mandatory to perform of Chlamydia trachomatis infected individuals in Sweden, there was a 10-15% annually increase of reported cases between 1997 and 2007 indicating that partner notification may not be effective in preventing transmission. The investigators wanted to determine whether there was any difference in time between home-sampling and clinical testing as a tool of partner notification measured from eliciting of partners to date of testing. |
LARS FALK; | 2006-11-01 |
| 301 | Phase II Randomized, Placebo-Controlled Double-Blind 4-Arm Trial for The Treatment of Non-Gonococcal Urethritis (NGU): Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at the safety, effectiveness, and tolerability of combination medications for the initial treatment of non-gonococcal urethritis (NGU). NGU is inflammation of the tube that carries urine from the bladder. NGU is caused by bacteria that may be passed from person to person during sex. This study will compare the 2 currently recommended NGU treatments, doxycycline and azithromycin, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2006-11-01 |
| 302 | Epidemiology of Community Acquired Pneumonia in North Israel PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumonia in general and CAP in particular is considered as one of the most common bacterial infections, associated with high rates of morbidity and mortality and is highly significant economically since all respiratory infections, and pneumonia especially, cause about 80% of antimicrobials use in the community. The high frequency of respiratory infections and the excessive use of antimicrobials are major contributors to the development of pathogens resistant to antimicrobials. In addition, in CAP almost all patients are treated empirically, without identification of causing pathogen. Aim of study: To identify common pathogens causing CAP in hospitalized patients in north Israel. |
FAHMI SHIBLI; | 2006-11-01 |
| 303 | A Randomized Trial of Spectroscopy Versus Standard Care in Cervical Intraepithelial Neoplasia Related Papers Related Patents Related Grants Related Experts View Highlight: Primary objectives 1. To conduct a randomized clinical trial of the emerging technology fluorescence and reflectance spectroscopy, comparing colposcopy to colposcopy + spectroscopy in the diagnostic setting, stratifying patients by outside Papanicolaou (Pap) smear of low grade and high grade squamous intraepithelial lesions, and to use multispectral digital colposcopy retrospectively. The number of clinically read referral Paps, clinically read UT MD Anderson Cancer Center (MDACC) Paps, quantitatively read Paps, quantitatively read biopsies, point probe fluorescence/reflectance spectroscopy, and the multi-spectral digital colposcopy image, that shows a possible cancer, High-grade Squamous Intraepithelial Lesion (HGSIL), Low-grade Squamous Intraepithelial Lesion (LGSIL), … |
HELEN E. RHODES; | 2006-11-01 |
| 304 | Randomized Evaluation of Short-Term Rifalazil Treatment on Carotid Atherosclerosis and Intima Media Thickness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate an antibiotic therapy called Rifalazil to determine its effect on hardening of the carotid arteries. |
ACTIVBIOTICS | 2006-10-01 |
| 305 | SIP 4-04 Evaluation of Abstinence-Only and Abstinence-Plus Program to Prevent HIV, STD, and Pregnancy Among Middle School Students PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the efficacy of two curricula relative to standard care. The first is a sexual risk avoidance curriculum for middle school students that included abstinence until marriage and complies with Title V Section 510 A-H abstinence education requirements. The second is a sexual risk reduction curriculum for middle school students that included abstinence and condom/contraceptive information and skills. Each intervention consists of an age-appropriate classroom curriculum and a CD-ROM-based tailored intervention delivered in 7th and 8th grade. The overall goal of the study is to identify common elements of effective sexuality education curricula that will be of benefit to youth. |
CHRISTINE MARKHAM; | 2006-09-01 |
| 306 | Bronchiectasis in COPD Patients : Role of Prophylaxis With Inhaled Steroids and Antibiotic on The Natural History of The Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchiectasis is a chronic pulmonary disease characterized by an irreversible dilatation of the bronchi. The current view of the pathogenesis of bronchiectasis considers initial colonization of the lower respiratory tract by different microorganisms as the first step leading to an inflammatory response characterized by neutrophil migration within the airways and secondary secretion of a variety of tissue-damaging oxidants and enzymes such as neutrophil elastase and myeloperoxidase. Persistence of microorganisms in the airways because of impairment in mucus clearance may lead to a vicious circle of events characterized by chronic bacterial colonization, persistent inflammatory reaction, … |
UNIVERSITY OF MILAN | 2006-09-01 |
| 307 | A Clinico-pathological Phase II Study With Translational Elements to Investigate The Possible Infective Causes of Non-Hodgkin Lymphoma of The Ocular Adnexae With Particular Reference to Chlamydia Species and The Effects of MALT Lymphoma Treatment With Tetracycline PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with mucosa-associated lymphoid tissue (MALT) lymphoma of the ocular adnexae (MLOA) will be eligible for treatment with doxycycline (part A: clinico-pathological study); patients with other types of ocular lymphoma, inflammatory lesions or those ineligible/unwilling for treatment with doxycycline can participate in the only pathologic study (part B). |
INTERNATIONAL EXTRANODAL LYMPHOMA STUDY GROUP IELSG | 2006-09-01 |
| 308 | Eliminating Trachoma With Repeat Mass Drug Treatment PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The WHO has initiated a program to eliminate trachoma, blinding eye infection caused by Chlamydia trachomatis, in large part by mass distributions of oral azithromycin. The proposed study will determine the frequency and treatment target of community-wide mass antibiotic treatment. We will also study the impact of mass antibiotic distribution on antibiotic-resistance in pneumococcus. |
THOMAS M. LIETMAN; | 2006-06-01 |
| 309 | Asthma Clinical Research Network (ACRN) Trial – Macrolides in Asthma (MIA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma can be caused by a variety of factors, including tobacco smoke, allergens, and respiratory airway infections. Many people use inhaled corticosteroid medications to treat their symptoms. These medications, however, are not effective for everyone. Clarithromycin is an antibiotic that may effectively treat asthma in these individuals. This study will evaluate the effectiveness of clarithromycin at controlling asthma symptoms. |
VERNON M. CHINCHILLI; | 2006-06-01 |
| 310 | Phase 3 Trial to Assess The Efficacy of Long-term (6 Months) Combination Antibiotics As A Treatment for Chlamydia-induced Reactive Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Reactive arthritis, also known as Reiter’s syndrome, is a form of arthritis that occurs as a reaction to an infection elsewhere in the body. It is characterized by inflammation of the joints, tendons, urogenital tract, and eyes. Pain and swelling in the knees, ankles, and feet are common. This study will determine the effectiveness of antibiotic therapy in treating people with chlamydia-induced reactive arthritis that has lasted for more than 6 months. |
JOHN D. CARTER; | 2006-05-01 |
| 311 | Intravaginal LACTIN-V for Prevention of Recurrent Urinary Tract Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Recurrent urinary tract infections (RUTIS) continue to be a major health problem in women and are now complicated by increasing antibiotic resistance. New preventive approaches are needed. Because most women with RUTI lack the normal protective Lactobacillus (LB) in their vaginal flora, we hypothesized that restoration of LB would reduce RUTIS. In this trail, women with recent UTI are randomized to receive either LB or placebo vaginal capsules and are followed for side effects, for colonization with LB and for occurrence of RUTI over hte next four months. |
ANN STAPLETON; | 2006-03-01 |
| 312 | Beneficial Effects of Oral Premarin Estrogen Replacement Therapy Assessed By Human Genome Array PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the immunological status of patients using Premarin. Premarin use is associated with an enhanced immune status, and possibly even some anti-cancer effect. The researchers will compare the use of Premarin with those not using hormone replacement therapy (HRT) to track the effects of Premarin in reducing the risk of infection and swelling. |
GREGOR REID; | 2006-03-01 |
| 313 | Home Sampling Versus Conventional Sampling for Screening of Urogenital Chlamydia Trachomatis in Young Men and Women. – A Randomised Control Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Urogenital Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection in Norway. Urogential C.trachomatis infection can easily be treated with antibiotics. However, left untreated it is a major cause of pelvic inflammatory disease (PID) that can lead to complications such as infertility, … |
NORWEGIAN INSTITUTE OF PUBLIC HEALTH | 2006-02-01 |
| 314 | Chlamydia Trachomatis Persistence in The Female Gastrointestinal Tract Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if Chlamydial infections persist in the rectum of females who have had a sexually transmitted infection of Chlamydia. |
AMY M SCURLOCK; | 2006-02-01 |
| 315 | A Multicenter, Open-label Study on The Efficacy, Cycle Control and Safety of A Contraceptive Vaginal Ring Delivering A Daily Dose of 150 Ug of Nestorone® and 15 Ug of Ethinyl Estradiol PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this 1-year study is to evaluate the efficacy and safety of a new contraceptive vaginal ring (CVR) delivering low doses of Nestorone (NES), a new, nonandrogenic progestin, and ethinyl estradiol (EE), an estrogen used in oral contraceptives. The CVR, which is made of silicone rubber, is designed to be used for 1 year (13 menstrual cycles) before replacement is required. |
POPULATION COUNCIL | 2005-12-01 |
| 316 | Determination of The Impact of Water and Health Education on Trachoma and Ocular C. Trachomatis in Niger PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: There are no specific trials addressing the benefit of water provision and health education on prevalence of trachoma and infection with ocular Chlamydia trachomatis over time, despite considerable effort to provide water resources in trachoma endemic areas. Such information is sorely needed, to advance the Global Alliance agenda for the Elimination of Blinding Trachoma. This community-based clinical trial will randomize ten communities in Maradi Niger, half to receive delivery of water and health education services, … |
SHEILA K WEST; | 2005-12-01 |
| 317 | Randomized Controlled Trial (RCT) in Children With Severe Pneumonia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumonia is the leading cause of childhood morbidity and death in many developing countries including Bangladesh, causing about 2 million deaths worldwide each year. Pneumonia is an infection of the lungs, most commonly caused by viruses or bacteria like Streptococcus pneumoniae and Haemophilus influenzae. Depending on the clinical presentation, pneumonia can be classified as very severe, severe or non-severe, with specific treatment for each of them except for antibiotic therapy. Severe and very severe pneumonia require hospitalization for additional supportive treatment such as suction, oxygen therapy and administration of bronchodilator. In Bangladesh, … |
HASAN ASHRAF; | 2005-12-01 |
| 318 | HIV/STI Prevention for Drug-Involved Couples PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial is designed to address gaps in couple-based HIV prevention research by focusing exclusively on HIV negative concordant couples where one or both partners are drug-involved. Building on prior couple-based HIV research that resulted in an evidence-based HIV prevention model for couples (Connect), intervention components were modified to address dyadic drug risk reduction and drug-related unsafe sex and a couple-based HIV risk reduction intervention (Connect II) was designed specifically for drug-involved, HIV negative concordant heterosexual couples at risk for HIV/STIs. For this RCT, … |
LOUISA GILBERT; | 2005-11-01 |
| 319 | Prospective Evaluation of Rifalazil Effect On Vascular Symptoms of Intermittent Claudication and Other Endpoints in Chlamydia Seropositive Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine whether rifalazil can significantly increase peak walking time (PWT) in patients with peripheral arterial disease (PAD). |
ACTIVBIOTICS | 2005-11-01 |
| 320 | An International Multi-centre, Randomised, Double-blind, Placebo-controlled Trial to Evaluate The Efficacy and Safety of 0.5% and 2% PRO 2000/5 Gels for The Prevention of Vaginally Acquired HIV Infection PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to determine the efficacy and safety of 0.5% and 2% PRO 2000/5 gels compared to placebo in preventing vaginally acquired HIV infection. |
SHEENA MCCORMACK; | 2005-10-01 |
| 321 | An Open-Label, Randomized, Multicenter Trial to Evaluate Continuation Rates, Side Effects and Acceptability of NuvaRing Versus OrthoEvra PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label prospective, multicenter, randomized trial to compare continuation rates into the fourth cycle of women using either the NuvaRing or OrthoEvra. Five hundred women will be recruited at 9 centers nationwide to be randomly assigned to use either the NuvaRing or OrthoEvra for four months. Women must either be on the pill or have recently stopped the pill and be relatively satisfied with oral contraceptive use to qualify for enrollment. Two visits and two phone calls will be required. |
MITCHELL D CREININ; | 2005-06-01 |
| 322 | Azithromycin in Control of Trachoma II Related Papers Related Patents Related Grants Related Experts View Highlight: Trachoma is the world’s leading cause of preventable blindness. This disease, caused by Chlamydia trachomatis, is endemic in many parts of the developing world. In 1990s we evaluated the use of community-wide treatment with oral azithromycin in a project called Azithromycin in Control of Trachoma (ACT). This approach resulted in clinical improvement and dramatic reduction in prevalence of chlamydial infection through a 1-year follow-up. We enrolled the ACT villages, as well as an additional village that had not had any prior treatments, … |
JULIUS SCHACHTER; | 2005-06-01 |
| 323 | Randomized Controlled Trial of An Group Intervention to Maintain HIV Prevention Gains in Female Adolescents PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, an intervention is tested that is designed to reduced risky sexual behaviors in adolescent females. Study design: – randomized, controlled study – participants: 640 girls aged 15-19 years old – length of follow-up: 1 year after the intervention is completed Study hypothesis: The experimental condition will significantly reduce risky sexual behaviors in adolescent females as measured by: – lower incidence of STI’s at 6 and 12 months, as compared to baseline – decreased incidence of risky sexual behaviors – increased knowledge of the level of risk of certain behaviors – … |
DIANNE MORRISON-BEEDY; | 2004-12-01 |
| 324 | Brief Intervention to Reduce STDs in ER Drug Users PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the proposed project is to determine the effectiveness of a brief motivational intervention among Emergency Department (ED) patients who use cocaine and/or heroin to prevent Sexually Transmitted Infections (STIs) and Human Immunodeficiency Virus (HIV) by comparing cumulative incidence and frequency of safe sex behavior between intervention and standard voluntary counseling, testing and referral to substance abuse treatment (control) groups over a one year follow-up period. |
EDWARD BERNSTEIN; | 2004-11-01 |
| 325 | Prospective, Randomized, Double-Blind Placebo Controlled Study on Influenza Vaccination in Prevention From Coronary Events in Patients With Coronary Artery Disease Confirmed By Angiography PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Influenza vaccination is recommended in patients (pts) with cardiovascular disease, however there is a shortage of clinical studies proving its protective effect on clinical course of coronary artery disease (CAD). The aim of the study was to evaluate the effect of influenza vaccination on the incidence of coronary events in pts with CAD confirmed by coronary angiography. |
ANDRZEJ CISZEWSKI; | 2004-10-01 |
| 326 | Behavioral Intervention for Minority Adolescent Women PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this Stage II clinical trial is to test the efficacy of a culturally sensitive, cognitive-behavioral intervention to reduce sexual risk behavior among minority adolescents for prevention of sexually transmitted infection (STI/HIV), unintended pregnancy and abuse by changing high-risk sexual behaviors, decreasing substance use and encouraging contraceptive use. Its primary goal is to expand risk-reduction interventions created in previous studies to further increase intervention efficacy for this particularly vulnerable, high-risk group. An adolescent intervention has been created and pilot tested in developmental studies. Results indicated reductions in substance use, risk behaviors, unintended pregnancy, … |
JANE D CHAMPION; | 2004-10-01 |
| 327 | Azithromycin Treatment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and Tracheostomy. Effects on Recurrent Respiratory Infections, Inflammatory Parameters and Bacterial Persistence PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aims of the study – to evaluate the rate of enteric gram negative bacteria colonization in tracheotomised COPD patients – to evaluate the effect of azithromycin long-term treatment on Pseudomonas aeruginosa colonization and colony counts, and on reduction of the number of exacerbations/hospitalisations, antibiotic courses and steroid use. – to evaluate the Quality of Life of patients treated and not treated with azithromycin, using a validate Italian version of St George questionnaire – to evaluate the rate of chronic colonization with atypical pathogens – to evaluate the safety and tolerability of a long-term treatment with azithromycin, … |
FRANCESCO BLASI; | 2004-10-01 |
| 328 | Community-Based Trial of Screening for Chlamydia Trachomatis to Prevent Pelvic Inflammatory Disease PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Chlamydial infection is a common, sexually transmitted disease which women can have without knowing. Untreated, it can lead to an infection of the womb and fallopian tubes called pelvic inflammatory disease (PID), which can cause infertility. There has been only one trial of chlamydia screening and this was in American women in 1992 and used outdated tests. We now need to see if screening using modern tests and self-taken swabs works in a high risk, young, … |
PIPPA OAKESHOTT; | 2004-09-01 |
| 329 | Multimodal Physician Intervention to Detect Amblyopia (Recruiting Title Equipping Primary Care Physicians to Improve Care for Children) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Current research shows low rates of quantitative vision screening at preschool ages in the medical home. This study targets providers (PCPs) to evaluate the effectiveness of a web-based intervention to improve knowledge about strabismus, amblyopia and preschool vision screening, to increase preschool vision screening rates, and to improve rates of diagnosis of strabismus and amblyopia by eye specialists. |
WENDY L MARSH-TOOTLE; | 2004-09-01 |
| 330 | Trial of Viagra’ in Men With Chronic Pelvic Pain Syndrome Type III PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Viagra is a potent 5-PDE inhibitor that causes vasodilation in the penis and, therefore, erection in men with erectile dysfunction. Our hypothesis is that Viagra may improve the symptoms of men with Chronic Pelvic Pain Syndrome based on the following assumptions: Chronic Pelvic Pelvic Syndrome and Interstitial Cystitis involve poorly understood central and peripheral pain sensitization such as are seen in Chronic Sympathetic Dystrophy, also called Chronic Regional Pain Syndrome. This pain may be caused by constricted blood vessels resulting from past stress, … |
RICHARD E BERGER; | 2004-07-01 |
| 331 | Pediatrics:Chlamydia, Sickle Cell Anemia and Stroke Risk – Ancillary to STOP II Related Papers Related Patents Related Grants Related Experts View Highlight: To establish a link among Chlamydia infection, sickle cell anemia, and stroke risk. |
LORI STYLES; | 2004-07-01 |
| 332 | A Phase II/III Multicenter, Randomized, Double-masked, Study of The Safety and Contraceptive Efficacy of C31G Compared to Conceptrol® PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-masked, controlled, phase III study of repeated use of C31G vaginal gel compared to Conceptrol® Vaginal Gel as the primary method of contraception over six months (183 days) and at least six cycles of use. In addition, there is an opportunity for subjects to continue with study treatment for up to twelve months (365 days) and twelve cycles of treatment upon completion of the first six months of treatment. |
HEALTH DECISIONS | 2004-06-01 |
| 333 | Phase I Safety and Acceptability Study of The Investigational Vaginal Microbicide PRO 2000/5 Gel (P) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: PRO 2000 Gel is designed to be inserted into the vagina to protect women from getting HIV during sex. So far, PRO 2000 Gel has been tested for safety in 136 women from Europe and the United States. This study will evaluate the safety and acceptability of PRO 2000 Gel when used by women in Pune, India. The study will also examine what Indian women and men think about using PRO 2000 Gel. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2004-04-16 |
| 334 | Randomized Controlled Trial of Advanced Provision Emergency Contraception Among Women With Gonorrhea or Chlamydia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to determine whether providing non-contracepting women with gonorrhea or chlamydial infection with advanced provision emergency contraception (APEC) and condoms decreases their risk of becoming pregnant. |
MATTHEW R GOLDEN; | 2004-01-01 |
| 335 | Lungwena Antenatal Intervention Study. A Single-centre Intervention Trial in Rural Malawi, Testing Maternal and Infant Health Effects of Presumptive Intermittent Treatment of Pregnant Women With Sulfadoxine-pyrimethamine and Azithromycin PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine whether treatment of pregnant Malawian women with repeated doses of sulfadoxine-pyrimethamine and azithromycin antibiotics will prevent preterm deliveries and result in other health benefits both for the mother and the foetus/newborn. |
PER ASHORN; | 2003-12-01 |
| 336 | Testing The POWER Project: A Neighborhood Intervention Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The intent of this project is to replicate the POWER pilot campaign using a randomized controlled trial with neighborhoods as the unit of randomization and analysis. We plan to rigorously test the effects of the POWER campaign on women’s knowledge of, … |
SHEANA BULL; | 2003-11-01 |
| 337 | NIMH Multisite HIV/STD Prevention Trial for African American Couples PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effectiveness of a risk-reduction program in preventing the transmission of HIV and sexually transmitted diseases among African-American heterosexual couples, with one partner having been previously diagnosed with an HIV infection. |
JOHN JEMMOTT; | 2003-11-01 |
| 338 | Use of Self-collected Vaginal Swabs As An Innovative Approach to Facilitate Testing for Repeat Chlamydia Infection PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if, among women who were treated for a prior chlamydial infection, home-based, self-collected vaginal swabs can increase rescreening for chlamydia in comparison with rescreening in the clinic. The study design is two randomized trials with enrollment at multiple family planning clinics and sexually transmitted disease (STD) clinics following a common protocol. |
FUJIE XU; | 2003-10-01 |
| 339 | HIV Risk Reduction Among Young Incarcerated Females PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project assesses the efficacy of an HIV prevention program with adolescent females incarcerated in the Mississippi training school for girls. Participants in both the health education control group and the HIV prevention group will increase health knowledge as a result of their participation in the health classes while incarcerated. However, participants in the HIV prevention group will increase their condom application, assertiveness, and communication skills relative to girls in the health education only group. In addition, after release from the training school, … |
ANGELA A. ROBERTSON; | 2003-09-01 |
| 340 | Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and The Community PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial conducted in Rakai District, Uganda, has enrolled 997 HIV positive men and 500 men who declined to learn HIV results (regardless of HIV status). The hypotheses are that male circumcision will be acceptable to and safe in both groups and will reduce the rates of STD acquisition in both groups and of HIV acquisition in HIV-negative men. Enrollment was ended on Dec 12, 2006, … |
DAVID SERWADDA; | 2003-08-01 |
| 341 | Nucleic Acid Amplification Tests for The Diagnosis of Pharyngeal and Rectal Chlamydia Trachomatis and Neisseria Gonorrhoeae Infections PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators at the University of Alabama in Birmingham in collaboration with investigators from the Centers for Disease Control in Atlanta are evaluating the performance of three commercial nucleic acid amplification tests for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae in pharyngeal and rectal swab specimens. Cultures for C. trachomatis and N. gonorrhoeae are performed as additional reference tests. Study subjects are men and women attending sexually transmitted disease (STD) and HIV care clinics in Birmingham, Alabama, who report sexual behaviors that place them at risk for pharyngeal or rectal sexually transmitted infections. |
LAURA H. BACHMANN; | 2003-06-01 |
| 342 | Multicenter Randomized Controlled Trial Evaluating The Efficacy of HIV/STD Prevention Counseling and Testing in Preventing High Risk Behaviors and New Sexually Transmitted Diseases (Project RESPECT) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The efficacy of counseling to prevent infection with the human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs) has not been definitively shown. This multi-center randomized controlled trial (Project RESPECT) sought to compare the effects of 2 interactive HIV/STD counseling interventions with didactic prevention messages typical of current practice. A total of 5758 STD clinic patients were enrolled from 5 public STD clinics (Baltimore, Md; Denver, Colo; Long Beach, Calif; Newark, NJ; and San Francisco, Calif) between July 1993 and September 1996. Eligible participants were heterosexual, … |
MARY L KAMB; | 2003-04-01 |
| 343 | Trachoma Elimination With Repeated Mass Azithromycin Treatments PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The WHO has initiated a program to eliminate blinding trachoma by the year 2020, in large part by mass oral azithromycin distributions. It is not clear how frequently or for how long these treatments are necessary. Here we assess the frequency and duration of treatment. |
THOMAS M LIETMAN; | 2003-03-01 |
| 344 | Using The Healthcare Visit to Improve Contraceptive Use PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Consistent and correct use of an effective contraceptive method is a primary determinant in preventing pregnancy. Unfortunately, only a minority of healthcare providers adequately address women’s contraceptive needs. We have developed a standardized behavioral-based contraceptive counseling model that can be used by providers and other clinic staff to address this limitation. The model, ESP, is an adaptation of motivational interviewing and involves: Exploring discrepancies between pregnancy intention and contraceptive use and between risk of STDs and condom use; Sharing information; … |
RUTH PETERSEN; | 2003-03-01 |
| 345 | Prospective Study of Possible Infectious Disease – Associated Antigen Drive in Previously Untreated Indolent Lymphoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if an infectious disease may be associated with the new lymphoma diagnosis. Infections to be tested include: 1. Helicobacter pylori (H. pylori): This is a bacteria sometimes found in the stomach that has been associated with a particular kind of lymphoma, … |
CAROL PORTLOCK; | 2003-02-01 |
| 346 | New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis: Immunostimulation Plus Antibiotic Versus Immunosuppression Plus Antibiotic Versus Conventional Standardtherapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. to investigate, whether one of the two alternative therapy strategies (antibiotic plus immunostimulation versus antibiotic plus immunosuppression) in chronic reactive arthritis is therapeutical superior to conventionel standardtherapy (DMARD). 2. to investigate, … |
JOACHIM SIEPER; | 2003-01-01 |
| 347 | Diagnosis of Ventilator- Associated Pneumonia in Children: A Comparative Study of Bronchoscopic and Non-Bronchoscopic Methods Related Papers Related Patents Related Grants Related Experts View Highlight: Background and Objectives: There is a need to validate and suggest easy and less costly diagnostic method for diagnosis of ventilator-associated pneumonia in developing country. The study was performed to compare available methods for the diagnosis and to characterize the organisms causing VAP. Design and Methods: All patients on mechanical ventilation for more than 48 hours and simplified CPIS ≥ 6 were enrolled prospectively. Four diagnostic procedures, endotracheal aspiration (ETA), blind bronchial sampling (BBS), … |
ANIL SACHDEV; | 2003-01-01 |
| 348 | Increased Access to Emergency Contraceptive Pills PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effect of easy access to emergency contraceptive pills (ECPs) on the rates of pregnancy and sexually transmitted infections (STIs). |
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT NICHD | 2002-10-01 |
| 349 | STARS: Sistas Talking About Real Solutions PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: STARS: Sistas Talking About Real Solutions is a health education intervention for African-American women, ages 18-29 aimed at reducing their risk for HIV. A total of 855 subjects were recruited from three Kaiser Permanente Medical Centers. Members were randomly selected from the membership database and sent a letter via mail introducing them to the project and inviting them to participate. Letters were followed up with a phone call and potential participants were screened for eligibility. To be able to participate, participants had to be African-American, female, between the ages of 18-29, single, … |
GINA M WINGOOD; | 2002-10-01 |
| 350 | A Pilot Study: Measurement of Digital Colposcopy for Fluorescence Spectroscopy of Cervical Intraepithelial Neoplasia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall objective of this study is to identify potential improvements for a noninvasive method of diagnosing dysplasia and neoplasia in the cervix using digital colposcopy for colposcopy for fluorescence spectroscopy. Other Objectives: – To measure digital fluorescence and reflectance images in vivo of sites in the human cervix. – To evaluate the effect of acetic acid in the image contrast obtained. – Compare the device performance to colposcopy and pathologic analysis of tissue removed at colposcopy. |
MICHELE FOLLEN; | 2002-09-01 |
| 351 | Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Multiple sclerosis (MS) is an inflammatory, demyelinating disease which affects the central nervous system (CNS). The etiology of MS is unknown, although the immune system appears to play a role. Many different infectious agents have been proposed as potential causes for MS, including Epstein-Barr virus, human herpesvirus 6, … |
NATIONAL CENTER FOR RESEARCH RESOURCES NCRR | 2002-08-07 |
| 352 | Endothelial Dysfunction As A Risk Factor in HIV Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Highly active antiretroviral therapy (HAART) has proven effective in altering the natural history of HIV infection in many patients. However, this therapy may not be sustainable because of the toxicities of the medications. Evidence suggests that HIV-infected patients on HAART may be at risk for premature coronary artery disease. The exact cause is unknown. It is possible that the medications directly affect the endothelium (the lining of the arteries that supply blood to the heart) and lead to premature heart disease. Or because the medications cause lipid abnormalities (high cholesterol) and a condition of relative insulin resistance, … |
NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER CC | 2002-05-01 |
| 353 | Reducing HIV Risk in Female Teens: A Tailored Approach PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The Horizons Program will test the efficacy of a multi-session HIV prevention program for African American female teens attending reproductive health clinics in Atlanta, GA. |
RALPH J. DICLEMENTE; | 2002-04-01 |
| 354 | Prevalence of Chlamydia Pneumoniae and Mycoplasma Pneumoniae in Different Forms of Obstructive Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To test the association between anti-Chlamydia serum titers and anti-Mycoplasma antibodies with Acute Coronary Syndromes. |
HOSPITAL DE BASE | 2002-03-01 |
| 355 | Study of Reproductive Health in Rural Madagascar With Emphasis on Urogenital Schistosomiasis and Sexually Transmitted Infections PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A cross-sectional study of urogenital schistosomiasis and sexually transmitted infections (STI) prevalence and associated morbidity in a rural community in Madagascar. Clearance of infections and resolution of morbidity were subsequently studied in two phases following systematic anti-STI and anti-schistosoma treatment, respectively. |
PETER DC LEUTSCHER; | 2001-08-01 |
| 356 | Computer-assisted STD Partner Notification PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To help public health professionals (DIS) in interviews of patients infected with STD for the names of their sex partners, this project used a computer-based partner elicitation program before the actual DIS interview. The main outcome was the mean number of partners named by those who had the intervention versus those those who did not. |
MATTHEW HOGBEN; | 2001-04-01 |
| 357 | Partner Notification for Chlamydia in Primary Care: Randomised Controlled Trial and Economic Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to compare the effectiveness of partner notification by general practice nurses with referral to a specialist clinic for people with genital chlamydia diagnosed in a community setting. We hypothesised that referral to a specialist would be more effective in ensuring treatment of the sexual partners of infected people than the simpler nurse-led strategy. |
UNIVERSITY OF BRISTOL | 2001-03-01 |
| 358 | Double-Blind Placebo-Controlled Clinical Effectiveness Trial of The 23-Valent Pneumococcal Vaccine Among Military Trainees At Increased Risk of Respiratory Disease PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective is to determine the clinical benefit of employing the 23-valent pneumococcal vaccine among US military trainees. Secondary objectives include: – determining the etiology of clinical pneumonia among U.S. military trainees; – comparing the serotype distribution of S. pneumoniae (Sp) isolates recovered from vaccinated and nonvaccinated trainees diagnosed with pneumonia; and – comparing days lost from training due to pneumonia or acute respiratory disease for vaccinated and nonvaccinated subjects. |
KEVIN RUSSELL; | 2000-10-01 |
| 359 | The Participant Agreement for Contact Tracing (PACT) Study: Enhancing Partner Notification Services PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients diagnosed with chlamydial infections (a sexually transmitted disease) are asked to notify their sex partners and tell them to seek medical evaluation. This project tests an enhancement to the materials provided to patients to help convince their partners to seek evaluation against the standard of care, which is a brief notification instruction. The desired outcomes are greater levels of notification by participants of their partners and lower levels of reinfection among participants. |
MATTHEW HOGBEN; | 2000-10-01 |
| 360 | Risk Factors for CV Disease in A Dialysis Cohort Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate whether traditional risk factors and novel risk factors predict higher risk of atherosclerotic cardiovascular disease (ASCVD) in a prospective study of incident dialysis patients. |
JOSEF CORESH; | 2000-09-01 |
| 361 | Costs and Effects of Early Switch of Intravenous to Oral Antibiotics in Severe Community-Acquired Pneumonia: A Multicenter Randomized Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with severe community-acquired pneumonia are included Half of the patients are treated with a 3 day course of intravenous antibiotics, followed, when clinical stable, by a course of oral antibiotics. Efficacy of this treatment is compared to a standard course of 7 days of intravenous antibiotics, which treatment is assigned to the other half of patients. Outcomes measured are clinical cure and costs. |
ANDY IM HOEPELMAN; | 2000-07-01 |
| 362 | Safety and Efficacy of Two Screen-and-Treat Approaches for The Prevention of Cervical Cancer PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The study measures the impact of screen-and-treat on the prevalence of high-grade cervical intraepithelial neoplasia and cancer (CIN 2+). It is a three-arm, randomized clinical trial comparing two screen-and-treat approaches to delayed evaluation as a control. The primary outcome is biopsy-confirmed CIN 2+ at 6 months and significant complications within 6 months of randomization with continued follow-up to detect CIN2+ and other complications up to 36 months post-randomization. |
THOMAS C WRIGHT; | 2000-01-01 |
| 363 | The Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease – A Randomized, Placebo Controlled, Double Blinded, Multicentre, Clinical Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A growing body of evidence links Chlamydia pneumoniae to the progression of coronary heart disease. The purpose of this study is to determine the positive and negative effect of 14 days treatment with clarithromycin 500 mg daily in patients already suffering from stable coronary heart disease. The participants will be followed for at least two years after the treatment. Abbott Laboratories supplied Clarithromycin and placebo tablets. |
CHRISTIAN GLUUD; | 1999-10-01 |
| 364 | ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The ASTHMA Pilot Study is a randomized, controlled, parallel group clinical trial of 6 weekly doses of azithromycin (cumulative dose 4800 mg) or placebo as adjunctive treatment in addition to usual care for adults with stable persistent asthma, with final follow up at 3 months after completion of study medication. The hypothesis to be tested is that antibiotic treatment will improve asthma at followup, and that this improvement will be limited to patients with evidence of C. pneumoniae infection. The secondary hypothesis is that randomized, controlled treatment trials can be carried out successfully in a geographically dispersed practice-based research network. |
DAVID L HAHN; | 1999-09-01 |
| 365 | Home Screening for Chlamydia Surveillance PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled trial to determine whether a home screening test for chlamydia and gonorrhea will lead to increased use of screening tests and increased detection of sexually transmitted diseases. |
ROBERTA B NESS; | 1999-06-01 |
| 366 | Immunomodulatory Effects of Hormone Therapy in Postmenopausal Women With Chronic Chlamydia Pneumoniae or Cytomegalovirus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hardening of the arteries (atherosclerosis) and heart disease are much more common in men than in women. However, as women grow older, especially after menopause the incidence of atherosclerosis and heart disease increases. These findings suggest that estrogen may be protective and help in preventing heart disease. Studies of large groups of post-menopausal women suggest that hormone replacement therapy (therapy that includes estrogen) reduces the risk of heart disease. Estrogen causes favorable changes in particles that carry cholesterol in the blood stream and improves function of blood vessels. Estrogen may also stimulate the immune system’s ability to fight off infections that may lead to or contribute to atherosclerosis. Researchers believe two specific infectious agents (Chlamydia pneumoniae and human cytomegalovirus) may cause damage to the lining of blood vessels resulting in inflammation and the development of atherosclerosis. The purpose of this study is to determine if estrogen treatment can change how the immune system responds to chronic infections, by Chlamydia pneumoniae and human cytomegalovirus, in postmenopausal women. |
NATIONAL HEART LUNG AND BLOOD INSTITUTE NHLBI | 1999-05-01 |
| 367 | Infection and Cardiovascular Disease Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate the role of chronic infection as a risk factor for vascular disease in a study of Native Americans. The primary focus is on the two most common agents Chlamydia pneumoniae and cytomegalovirus with a secondary emphasis on Helicobacter pylori. |
MICHAEL DAVIDSON; | 1999-04-01 |
| 368 | Azithromycin and Coronary Events Study (ACES) Related Papers Related Patents Related Grants Related Experts View Highlight: To determine whether treatment with azithromycin decreases the rate of coronary heart disease events among patients with stable documented coronary artery disease. |
J. GRAYSTON; | 1998-09-01 |
| 369 | Inflammation, Infection, and Future Cardiovascular Risk Related Papers Related Patents Related Grants Related Experts View Highlight: To examine markers of underlying chronic inflammation and infection as potential risk factors for future myocardial infarction (MI), stroke (CVA), and venous thromboembolism (VTE) in plasma samples collected at baseline from healthy participants in the Physicians’ Health Study (PHS). |
PAUL RIDKER; | 1998-09-01 |
| 370 | Study of Hispanic Acculturation Reproduction and The Environment (SHARE) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The most persistent and intractable cause of infant and child mortality and morbidity in the US remains preterm and low birthweight deliveries. Pregnant women in the United States experience the highest incidence of these complications among developed countries. Even more disturbing is the observation that immigrant Hispanic women experience worsening birth outcomes the longer they live here, despite increasing access to prenatal care, … |
MARC B SCHENKER; | 1998-08-01 |
| 371 | CSP #706D – HIV Seroprevalence and Risks in Veterans With Severe Mental Illness Related Papers Related Patents Related Grants Related Experts View Highlight: It is suspected, but not well documented, that persons with severe mental illness (SMI) represent a significant transmission source of serious infectious diseases. SMI diagnoses are defined as schizophrenia, schizoaffective disorder, bipolar disorder, or posttraumatic stress disorder (PTSD). Severely mentally ill persons are at high risk for Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS). To assess the risk of HIV and related infections among these individuals, … |
US DEPARTMENT OF VETERANS AFFAIRS | 1998-01-01 |
| 372 | Populationbased Screening for Urogenital Chlamydia Trachomatis Infections By Use of Home-Obtained and Mailed Samples: A Randomized Study PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: 30,000 individuals living in Aarhus County, Denmark by Oct 1997 were randomized into two groups. The intervention group received an invitation to be tested for urogenital Chlamydia trachomatis by use of home-obtained and mailed sample (9,000 individuals). The control group received no intervention (21,000 individuals). Outcome measures: Number of tested individuals, number of detected infections, number of women developing PID, ectopic pregnancy or infertility, number of women giving birth to a child, … |
BERIT ANDERSEN; | 1997-10-01 |
| 373 | Hormonal Contraception, Cervical Ectopy, and STDs PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: There are biological reasons to suspect that hormones may affect the risk of a woman becoming infected with a sexually transmitted disease. The evidence on this issue to date is mixed and previous studies have methodologic flaws making it difficult to draw conclusions about the results. This study compares the risk of developing either Chlamydial or Gonorrheal infection among three groups of women: those using combined oral contraceptives (birth control pills); those using the injectable hormone (brand name Depo Provera); and those women using non-hormonal contraceptive methods. |
CHARLES MORRISON; | 1997-09-01 |
| 374 | Epidemiology of Carotid Artery Atherosclerosis in Youth PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine the relationship of risk factors measured in childhood to intimal medial thickness (IMT) in early adulthood and to examine familial factors which may be related to increased IMT, a measure of atherosclerosis. |
PATRICIA H DAVIS; | 1995-09-01 |