Clinical Digest: Recent Clinical Trials on Chronic Obstructive Pulmonary Disease
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Chronic Obstructive Pulmonary Disease. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Chronic Obstructive Pulmonary Disease
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Standard Vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test titrated oxygen in prehospital patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The main question it aims to answer is: * To determine whether prehospital titrated oxygen strategy in patients with suspected AECOPD will decrease 30-day mortality compared to patients receiving standard care. Participants in the intervention will receive titrated oxygen – a mix of supplemental oxygen and compressed atmospheric air as driver for inhaled bronchodilators to target SpO2 (oxygen saturation) 88-92%. The intervention will be compared to standard treatment, … |
MARTIN F GUDE; | 2025-05-01 |
| 2 | Point-of-Care Ultrasound-Guided Diuresis for Acute Decompensated Heart Failure to Reduce 30-Day Readmissions and Acute Kidney Injury PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness. In severe cases, these symptoms worsen to the point where hospitalization is required. Unfortunately, many patients with severe heart failure are readmitted to the hospital within 30 days after discharge, which is both physically and emotionally challenging for patients and places a significant financial burden on individuals and the healthcare system. Although symptoms such as difficulty breathing and swelling may improve during the hospital stay, … |
JOHN PACELLA; | 2025-05-01 |
| 3 | The Effect of A Nurse Navigator Program on Readmission Rates for Patients With Elevated BMI, COPD, CHF, Dialysis Use, and H/o Alcohol Abuse PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine if educational intervention in high risk patients can lead to decreased hospital readmissions when compared to patients who are not in the intervention program. Additionally, to determine patient satisfaction with the educational program. |
GEORGE PUJALTE; | 2025-05-01 |
| 4 | A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Trial to Evaluate The Efficacy and Safety of Rademikibart As An Add-on Treatment for Acute Exacerbation in Participants With Chronic Obstructive Pulmonary Disease and Type 2 Inflammation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2, multicenter study in adult participants with an acute COPD exacerbation and type 2 inflammation |
CONNECT BIOPHARM | 2025-05-01 |
| 5 | Evaluating A Respiratory Oxygen Adherence Monitor for COPD Patients With Long-term Oxygen Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test a device called ROAM that is being developed to see how patients with chronic obstructive pulmonary disease (COPD) use oxygen therapy over a long period of time. This study will focus on evaluating the ROAM device, … |
EILEEN KREPKOVICH; | 2025-05-01 |
| 6 | COPD BALANCE: A Feasibility Study of Internet-Based Cognitive Behavioral Therapy and Educational Intervention to Improve Mental Health, Disease Knowledge, and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if an internet-based cognitive behavioral therapy (CBT) and education program can help improve mental health, disease knowledge, and quality of life in adults with chronic obstructive pulmonary disease (COPD). This is a feasibility study, meaning researchers want to find out if this online treatment program is practical, acceptable, and effective enough to use in a larger future study. The main questions it aims to answer are: Can internet-based CBT and disease education help participants feel less anxious, depressed, … |
JONAS AGHOLME; | 2025-05-01 |
| 7 | A Prospective, Multicenter, Randomized Controlled Clinical Trial Comparing Bronchoscopic Thermal Vapor Ablation and Percutaneous Microwave Ablation in Patients With COPD and Early-Stage Lung Cancer: Efficacy and Safety Evaluation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Based on the advantages of BTVA in the treatment of early-stage lung cancer and COPD, researchers propose the concept of using BTVA to treat COPD combined with early-stage lung cancer. Researchers plan to conduct a multicenter clinical study focusing on patients with COPD combined with malignant GGNs. Bronchoscopic BTVA surgery or percutaneous MWA surgery will be performed, evaluating the effectiveness and safety of bronchoscopic BTVA and percutaneous MWA surgery in the treatment of COPD combined with early-stage lung cancer. |
HENAN PROVINCIAL PEOPLE’S HOSPITAL | 2025-05-01 |
| 8 | Ambulatory Oxygen Therapy for Individuals With Mild-to-moderate Interstitial Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators plan to conduct a study to find out if giving portable oxygen therapy (during physical activity) to patients with interstitial lung disease will improve quality of life, exercise tolerance, shortness of breath, and blood vessel function. Oxygen will be provided for a period of 8 weeks. Additionally, the investigators plan to investigate if it is helpful to deliver individualized support when providing oxygen therapy, through check-in phone calls with a respiratory therapist and by providing additional educational material. |
MIKE STICKLAND; | 2025-05-01 |
| 9 | A Study on COPD Phenotypes, Endotypes and Treatable Traits PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and multisystemic disease with progressive increasing morbidity and mortality. COPD is now widely accepted as a heterogeneous condition with multiple phenotypes and endotypes.The recognition of COPD phenotypes and endotypes has significantly impacted the management of the disease. Furthermore, treatable traits (TTs) are recognizable phenotypic or endotypic characteristics that can be assessed and successfully targeted by therapy to improve a clinical outcome in a patient with airway disease. The healthcare system in Hong Kong is different from that of other places. Previous studies in Hong Kong only looked at specific endotypes; … |
FANNY W.S. KO; | 2025-04-25 |
| 10 | Staging Heart Failure With Preserved Ejection Fraction By Assessing Cardiac Chamber Involvement With Echocardiography PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure with preserved ejection fraction (HFpEF) is considered a systemic condition in which the prevalence of cardiovascular, metabolic, pulmonary and renal conditions determine the extent of cardiac involvement. Numerous attempts have been made to phenotype HFpEF, but we still lack a clinically and/or prognostically relevant approach. Progressive cardiac deterioration in HFpEF appears to be associated with a worse prognosis. However, no attempt has been made to classify the extent of cardiac involvement in HFpEF. We proposed the concept of HFpEF staging according to the extent of cardiac involvement identified by transthoracic echocardiography: Stage 1: isolated left ventricular involvement; … |
ANASTASIA SHCHENDRYGINA; | 2025-04-20 |
| 11 | Personalised Music Feedback to Optimise Adherence to The Walking Exercise Prescription During Pulmonary Rehabilitation for Individuals Living With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary Rehabilitation (PR) is an evidence-based intervention to effectively manage the physiological and psychological effects of Chronic Obstructive Pulmonary Disease (COPD). The aims of PR are to improve symptoms of COPD, increase exercise capacity, increase independency, improve overall behaviour related to health (like exercising more), and enhance quality of life. The cornerstone of PR programmes is aerobic exercise prescription. Typically, walking exercise is used, and the prescription is individualised for each patient based on their maximal walking exercise capacity. However, adherence to walking exercise is challenging for service users, … |
MARK ORME; | 2025-04-20 |
| 12 | Chronic Airway Inflammation: The Impact of Respiratory Microbiota, Infection Characteristics, and Imaging Features on Disease Progression and Quality of Life-A Multomic and Comprehensive Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study，Respiratory microbiota, infection characteristics and imaging manifestations in patients with chronic airway inflammation， adopted a prospective, observational, multi-omics study design to comprehensively evaluate the effects of respiratory microbiota, infection characteristics and imaging manifestations on disease outcomes and quality of life in patients with chronic airway inflammation. Involving six parallel sub-studies, These include: (1) the differences and mechanisms of lung microecology in ICS treatment sensitivity and resistance in patients with chronic airway inflammation, (2) the study of respiratory viral infection and inflammatory markers in patients with acute exacerbation of chronic obstructive pulmonary disease, … |
FIRST AFFILIATED HOSPITAL OF NINGBO UNIVERSITY | 2025-04-15 |
| 13 | The Effect of Bedside Whiteboard Use on Anxiety, Depression and Nursing Care in Chronic Obstructive Pulmonary Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ABSTRACT Chronic obstructive pulmonary disease (COPD) is a disease characterized by the inability of the body to adequately exchange gases, resulting in progressive shortness of breath that can form secretions and compromise the performance of daily activities. COPD is reported as the third most common cause of death worldwide, with 3.23 million deaths in 2019. Anxiety and depression are common in individuals with COPD. However, COPD is more common in patients with other chronic diseases such as hypertension, diabetes, … |
RAMAZAN DENİZ; | 2025-04-15 |
| 14 | Comparison of Clinical Cure Rate of Doxycycline and Levofloxacin in The Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will include patients with chronic obstructive pulmonary disease (COPD) who present with an acute exacerbation. Participants will be randomly assigned to receive either doxycycline or levofloxacin for 5 days. The aim is to compare how effective each antibiotic is in improving symptoms after 2 days of treatment. |
AMINA ASLAM; | 2025-04-15 |
| 15 | A Phase II, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate The Efficacy and Safety of Tozorakimab in Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With A History of COPD Exacerbations and Elevated Eosinophils (COMETA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate lung function parameters, composite endpoint for exacerbations in chronic obstructive pulmonary disease (COPDCompEx), symptoms and to provide safety information after tozorakimab or placebo administrations in participants with symptomatic chronic obstructive pulmonary disease (COPD) with history of exacerbations and high blood eosinophil counts. Study details include the following: * The maximum duration of the screening/run-in period is 5 weeks. An additional unscheduled visit may be performed prior to randomization to repeat safety assessments as deemed necessary by the investigator. * Eligible patients will enter 12-week treatment (intervention) period with site visits and investigational product (IP) administration every 2 weeks. * Participants who complete a treatment period, and have not been prematurely discontinued from IP, will enter a 10-week post-intervention follow-up period. * The study duration will be 27 weeks at maximum for each participant. |
ASTRAZENECA | 2025-04-12 |
| 16 | Reliability and Validity of The Glittre Activities of Daily Living Test in Children and Adolescents With Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Juvenile Idiopathic Arthritis (JIA) is children’s most common inflammatory rheumatic disease. The International League of Associations for Rheumatology (ILAR) defines it as a chronic arthritis condition that begins before the age of 16 lasts for six weeks or more, and has an unknown cause. Despite the gains made in the management of the disease of individuals with JIA with modern medical treatment methods, the physical and psychosocial problems caused by chronic inflammation negatively affect the daily living activities of individuals with JIA. On the other hand, in the JIA Core Set created by Outcome Measures in Rheumatology (OMERACT) in 2018, … |
SINAN BURAN; | 2025-04-10 |
| 17 | Functional Efficiency, Respiratory Parameters and Blood Rheological Tests in Elderly People With Respiratory Diseases Participating in Pulmonary Rehabilitation in Underground Salt Chambers – A Prospective Experimental Study, Controlled in A Crossover Design PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to assess the impact of the rehabilitation and treatment stay at the underground Health Resort of the ‘Wieliczka’ Salt Mine in Wieliczka on the functional capacity, respiratory parameters, and rheological properties of blood in elderly individuals with respiratory diseases. |
UNIVERSITY SCHOOL OF PHYSICAL EDUCATION KRAKOW POLAND | 2025-04-04 |
| 18 | Decreasing Disparity in Lung Disease: Pulmonary Rehabilitation for Rural Patients With COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test the uptake, effectiveness, and patient-caregiver-provider experience of a crucial treatment not provided in rural areas: pulmonary rehabilitation. |
ROBERTO P. BENZO; | 2025-04-01 |
| 19 | Comparative Effects of Triple Inhaled Therapy With Budesonide/Glycopyrronium/Formoterol Versus Fluticasone Furoate/Umeclidinium/Vilanterol on Small Airway Disease in COPD Patients: A Randomized Crossover Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine if triple inhaled therapy with Budesonide/Glycopyrronium/Formoterol (BGF) and Fluticasone Furoate/Umeclidinium/Vilanterol (FUV) are effective in treating patients with stable chronic obstructive pulmonary disease (COPD). It will also assess the safety of both drugs. The main questions it aims to answer are: * Does BGF demonstrate a comparable effect to FUV in COPD participants? * What medical problems do participants experience when taking BGFand FUV? |
NARONGKORN SAIPHOKLANG; | 2025-04-01 |
| 20 | Usefulness of Oscillometry in Assessing The Effectiveness of Inhaled Corticosteroides in Patients With COPD Exacerbator Phenotype PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this observational study is to determine the effectiveness of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) and frequent worsening of their respiratory symptoms by using a device called an oscillometer. This instrument is capable of measuring bronchial obstruction and air trapping in the lungs through vibrations during normal breathing. The main question it seeks to answer is: Could oscillometry be useful in assessing the effectiveness of inhaled corticosteroids in patients with COPD exacerbations, … |
YULIANA PASCUAL GONZÁLEZ; | 2025-04-01 |
| 21 | Study on The Lung Aerosol Deposition of Ultrasonic Rock Salt Inhalation Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the in vitro modeling phase, the investigators plan to use a realistic human upper respiratory tract model and an asymmetric ideal bronchial tree model. By combining 3D printing experiments with CFD simulations, the investigators will investigate the respiratory tract deposition rate and distribution of micro – moist particles in ultrasound rock salt aerosol inhalation therapy. This will be compared with a small – volume nebulizer to verify the effectiveness of ultrasound rock salt aerosol inhalation therapy and lay the foundation for further research on the application of this inhalation technique to other drug formulations. In the clinical phase, … |
JINGEN XIA; | 2025-03-31 |
| 22 | Virtual Pulmonary Rehabilitation Program for COPD Patients; A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot study is to investigate the feasibility of a virtual rehabilitation program in COPD patients. The main questions it aims to answer are: 1. To facilitate a safe rollout of the remote rehabilitation program for COPD patients in Southwest Finland. 2. To identify and subsequently improve limitations of the rehabilitation program. 3. To evaluate the levels of participant engagement and adherence to the digital COPD rehabilitation program over an extended period to understand its sustainability and long-term impact. 4. To determine the effectiveness of the digital COPD rehabilitation program in improving lung function, exercise capacity, … |
MATTHIJS FEUTH; | 2025-03-31 |
| 23 | A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate The Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) |
MEILAN HAN; | 2025-03-25 |
| 24 | Effects of Virtual Reality Training on Balance and Fall Risk of Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine whether Virtual Reality (VR) training has significant effects on balance and fall risk of patients with COPD, with a focus on the patient group (GOLD STANDARD I \& II). Additionally, the study determines whether VR training is a reliable substitute for traditional physical therapy balance. |
SUMAN SHERAZ; | 2025-03-25 |
| 25 | Effects of Vibrating Mesh Nebulisation in Patients with COPD During Non-invasive Ventilation (VMN-NIV) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Assessment of the effects of vibrating mesh nebulisation versus jet nebulisation on the electrical activity of the muscles involved in breathing (neural respiratory drive), breathing mechanics (respiratory impedance measured by forced oscillation technique), respiratory flow, heart rate and rhythm, spirometry and breathlessness symptoms in patients with chronic obstructive pulmonary disease who require non-invasive ventilation. |
EUI-SIK SUH; | 2025-03-21 |
| 26 | Efficacy of Different Osteopathic Manipulative Techniques Combined With Diaphragmatic Release in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test the efficiency of rib rising technique and thoracic lymphatic pump technique combining with manual diaphragmatic release technique in patients with chronic obstructive pulmonary disease |
SHIMAA MOKHTAR; | 2025-03-20 |
| 27 | A Proactive Patient-centered Interactive Smartphone-based Self-Management Support Program for Patients with Chronic Obstructive Pulmonary Disease – A Pragmatic Randomized Controlled Trial with Mixed-method Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to find out if a smartphone-based program (called 3S-C) can help people with COPD live better, healthier lives. It will also look at how the program affects their knowledge, habits, and overall health. The main questions the study wants to answer are: * Does the 3S-C program help people with COPD feel better and improve their quality of life? * Does it help them understand and manage their condition better? * Does it improve their health, … |
AGNES LAI YUEN KWAN; | 2025-03-19 |
| 28 | Reducing Sedentary Behavior in Patients with Severe COPD: A Nurse-Led Motivational Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This feasibility study aims to assess the practicality and acceptability of a nurse-led motivational interview intervention designed to reduce sedentary behavior in patients with severe Chronic Obstructive Pulmonary Disease (COPD). The study will evaluate the recruitment process, patient adherence, and the usability of accelerometers for objectively measuring sedentary time. A total of 10-12 patients with severe COPD will be recruited and receive individual motivational interviews conducted by trained nurses in their homes. The intervention will be based on motivational interviewing (MI) and Cognitive Behavioral Therapy (CBT) principles, … |
ZEALAND UNIVERSITY HOSPITAL | 2025-03-19 |
| 29 | A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate The Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) |
DAVE SINGH; | 2025-03-18 |
| 30 | The Impact of Eecentric Exercise on Cardiopulmonary Fitness and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the effects of elliptical exercise on the six-minute walk test and quality of life in patients with chronic obstructive pulmonary disease (COPD) to identify the most efficient exercise training method. |
KE-YUN CHAO; | 2025-03-17 |
| 31 | Knee Extensors Force Control in People With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Maximal muscle strength is one of the most commonly assessed neuromuscular parameters in people with COPD due to its accessibility and relevance for prescribing an appropriate workload for resistance training. However, maximal force production is very rarely necessary during daily activities which requires production of submaximal and precisely controlled forces. Despite growing research on motor impairments in COPD, very little attention has been given to the effect of this disease on force control. Therefore, this research aims to better understand the potential deficits in force control caused by COPD, through the use of advanced signal processing methods (i.e., … |
CENTRE HOSPITALIER INTERCOMMUNAL DE TOULON LA SEYNE SUR MER | 2025-03-07 |
| 32 | Influence of Cognitive Load on Postural Control in People With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Postural control impairment is common in people with COPD (pwCOPD), which can increase the risk of falls and affect quality of life. However, the majority of existing studies examine this postural control in isolation, without taking into account the cognitive demands that occur during activities of daily living during which individuals are often required to perform a mental task while maintaining their balance. This research aims to fill this gap by studying how a cognitive task can influence postural control in pwCOPD. We hypothesized an impaired postural control in pwCOPD compared to healthy individuals, … |
CENTRE HOSPITALIER INTERCOMMUNAL DE TOULON LA SEYNE SUR MER | 2025-03-07 |
| 33 | Local Antibiotic Delivery for Community Acquired Pneumonia – Pilot Study (LANDCAP1) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, double-blinded clinical pilot study to assess whether addition of inhaled levofloxacin 240 mg twice daily for three days leads to improved or worsened physiological status in CAP patients with and without pre-existing lung disease. |
COPENHAGEN RESPIRATORY RESEARCH | 2025-03-04 |
| 34 | Study on The Efficacy and Mechanism of Acupuncture in The Acute Stage of Chronic Airway Diseases (Asthma and Chronic Obstructive Pulmonary Disease) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: For patients in the acute phase of chronic airway diseases, on the basis of guideline-directed treatment, the experimental group was given acupuncture treatment, while the control group was given sham acupuncture treatment. The treatment lasted for one week, followed by a 13-week follow-up. For asthma and COPD, PEF and CAT were respectively used as the primary outcome measures to evaluate the clinical efficacy and safety of acupuncture. Based on the improvement of the primary outcome measures, the advantageous population was identified. The mechanism by which acupuncture reduces airway mucus hypersecretion was preliminarily explained. |
HENAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE | 2025-03-01 |
| 35 | Early Cardiovascular Risk Assessment of Patients With COPD During Respiratory Exacerbation for The Identification and Treatment of Cardiovascular Comorbidity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a research study involving patients hospitalized for COPD flare-ups. Patients will be randomly assigned to two groups: one group will only see a pulmonologist (lung doctor), and the other group will also be seen by a cardiologist (heart doctor) during their hospital stay. Both groups will fill out a questionnaire, and the pulmonologist will review their lung disease, adjust their treatment, and recommend follow-up care. The cardiologist will also assess the second group for heart diseases (like high cholesterol, diabetes, heart disease, high blood pressure, … |
TEL AVIV SOURASKY MEDICAL CENTER | 2025-03-01 |
| 36 | Comparison Of Upper Extremity Exercise Capacity Of Breast Cancer Patients With Healthy Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Breast cancer is one of the most common cancers among women worldwide, with an incidence rate of up to 16%. Although survival can be improved with early diagnosis and more effective therapies, physical complications such as lymphedema, upper extremity dysfunction and chronic pain are common during and/or after breast cancer treatments. In addition, lymphedema can cause symptoms such as decreased muscle strength and range of motion of the upper extremity, pain and fatigue, resulting in activity limitations and decreased functional level of the upper extremity. |
EBRU CALIK KUTUKCU; | 2025-03-01 |
| 37 | Acute Effects of Inspiratory Muscle Training with Different Loads on Peripheral Muscle Metabolism and Autonomic Response in COPD Patients: A Randomized Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will evaluate the acute effects of inspiratory muscle training (IMT) on peripheral muscle metabolism and autonomic response in patients with chronic obstructive pulmonary disease (COPD). This is a randomized, crossover study, with blinding of the evaluator and the researcher responsible for the statistical analysis. Participants will be divided into three groups at different times: TMI- strength (F), TMI to gain inspiratory muscle strength; IMT- resistance (R), IMT for improving inspiratory muscle resistance; and TMI sham. All participants randomized in the study will participate in the three groups, … |
EDUARDO ERIKO TENÓRIO DE FRANÇA; | 2025-03-01 |
| 38 | Remote Monitoring of COPD Patients Experiencing An Acute Exacerbation Through Health Evaluations Using Wearable Mobile Technology PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) causes about 3 million deaths annually and significantly burdens healthcare systems, costing the EU 38.6 billion euros, largely due to frequent hospitalizations triggered by acute exacerbations (AECOPD). AECOPD worsens patient health, accelerates lung decline, and lowers quality of life, highlighting the need for early detection. Moreover, these AECOPD events happen in an out-hospital setting and are therefore, … |
DAVID RUTTENS; | 2025-03-01 |
| 39 | Comparison of The Effects of Home High-Flow Nasal Cannula Therapy and Noninvasive Ventilation in Patients with Stable Chronic Hypercapnic Respiratory Failure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effects of home high-flow nasal cannula (HFNC) therapy and noninvasive ventilation (NIV) in patients with stable chronic hypercapnic respiratory failure. The main questions it aims to answer are: * Does HFNC or NIV reduce blood carbon dioxide levels more effectively? * How well do patients tolerate and adhere to each therapy? * Are there differences in oxygen saturation, respiratory rate, … |
SANG-HA KIM; | 2025-03-01 |
| 40 | Temple Health Chest Initiative (THCI 2.0) – Lung Cancer Screening Project With COPD Detection PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease is highly prevalent globally, with considerable morbidity and mortality associated. In the US, it is the 4th leading cause of death, as well as contributing to significant costs on healthcare utilization including hospitalization. Population-based screening for COPD has not been recommended by the US Preventative Services Task Force (USPSTF). However, LDCT screening for lung cancer in patients aged 50- 80 with ≥ 20 pack year smoking has been shown to improve survival. COPD is highly prevalent within LCS programs, … |
GERARD CRINER; | 2025-02-28 |
| 41 | Mindful Steps: Coupling Technology and Mind-Body Exercise to Facilitate Physical Activity in Chronic Cardiopulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this fully-remote randomized controlled trial is to test the efficacy of Mindful Steps in facilitating physical activity compared to usual standard of care among 136 patients with COPD and/or HF. The main question it aims to answer is can this intervention promote physical activity as measured by daily step counts in sedentary patients with COPD and/or HF. Participants will be randomized (1:1 ratio) to receive either the Mindful Steps intervention or usual care for 12 months, with both arms receiving a Walking for Health education booklet. |
GLORIA Y. YEH; | 2025-02-28 |
| 42 | User-Centered Design of A COPD Care Pathway for Patients With Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study gathers information for the development of a COPD care pathway for patients with cancer that reduces the treatment burden of patients, implements critical components of COPD care, and overcomes common barriers to COPD care in the community oncology clinic. |
THOMAS LYCAN; | 2025-02-27 |
| 43 | BONG: Reducing Severe Breathlessness With Dronabinol in The Severe and Very Severe Chronic Obstructive Pulmonary Disease Patient Group – A Randomized, Double-Blind, Placebo-Controlled, Crossover Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial examines whether Dronabinol, which contains the synthetic psychoactive compound tetrahydrocannabinol (THC), can alleviate severe breathlessness in patients with severe and very severe chronic obstructive pulmonary disease (COPD). |
OLE HILBERG; | 2025-02-26 |
| 44 | Effect of Neuromuscular Electrical Stimulation of Lower Limbs on Improving Exercise Self-Efficacy, Dyspnea During Activity and Fatigue in Patients with Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients diagnosed with COPD who meet the inclusion and exclusion criteria, either inpatients or outpatients, will be informed about the study’sstudy’s purpose and procedures by the principal investigator. After understanding their rights, they will provide informed consent. |
KAOHSIUNG MEDICAL UNIVERSITY CHUNG HO MEMORIAL HOSPITAL | 2025-02-25 |
| 45 | A Randomized, Safety and Efficacy Study of Taneasy 600mg Granules and Fluimucil 600mg Granules in COPD Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and efficacy of Taneasy 600mg granules and Fluimucil 600mg granules administered twice daily for 14 days in treatment of COPD Disease. |
BUN YAO BIOTECHNOLOGY | 2025-02-20 |
| 46 | TELE-TOC: Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Transitions of Care (TOC) between hospital, ambulatory, and home settings for high-risk, frequently hospitalized adults with chronic diseases, such as chronic obstructive pulmonary disease (COPD) are complex, costly, and vulnerable to safety threats and poor health outcomes. One potential solution to address this gap in care is the Transitional Care Model (TCM), which utilizes a patient-centered approach with in-home interventions; since in-person in-home visits are costly, using innovative telehealth, such as virtual visits via teleconferencing may be just as effective with greater feasibility, scalability, and sustainability, … |
VALERIE G PRESS; | 2025-02-19 |
| 47 | Implementation and Impact Study of An Informational Tool for Smoking Cessation in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a lung disease that affects nearly 8% of the adult population and causes 18,000 deaths per year in France. The most frequent cause of this pathology is smoking. COPD patients who stop smoking have a better quality of life, a marked a significant slowdown in disease progression and an increased life expectancy. Investigators propose to carry out a quantitative study among patients smokers suffering from COPD, by setting up a tool in the form of an motivational intervention specific to this population. |
HOPITAL NORD FRANCHE COMTE | 2025-02-14 |
| 48 | Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified By Eosinophil Levels PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The 3TR-ICS COPD study is an international, multicentre, randomized, parallel, controlled study that will recruit clinically stable former smokers COPD patients (with no exacerbations in the previous 8 weeks) on treatment with dual long-acting bronchodilators (LABA+LAMA), minimum 8 weeks of usage, not receiving ICS (either naïve or \> 3 months since last usage). The overall objective of this clinical trial is to identify the molecular signatures associated with the molecular response to ICS treatment in patients with COPD stratified by the levels of circulating eosinophils, and the potential influence of the pulmonary microbiome |
MARIA JOYERA RODRÍGUEZ; | 2025-02-12 |
| 49 | A Phase I Clinical Study on The Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Characteristics of Single/Multiple Dose Escalation of TQC3927 Inhalation Powder in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project is the stage of dose escalation, is was divided into single and multiple dose clinical study, This is a multi-center, randomized, double-blind, placebo-controlled , study to the safety, tolerability and pharmacokinetic characteristics of TQC3927 powder for inhalation in Chronic Obstructive Pulmonary Disease |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2025-02-11 |
| 50 | Early Prediction of Acute Exacerbations of COPD Using Wearable and Portable Remote Monitoring Technology with AI/ML Empowered Platforms: A Prospective Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is aimed to collect real-time physiological data using two wearable devices (a biometric ring and a biometric wristband), daily lung mechanical measurements by a handheld oscillometer, and participant-reported symptoms in patients with COPD remotely from their home environment. The data will be used to train and validate artificial intelligence and machine learning (AI/ML) models to predict COPD exacerbations in advance of their actual occurrence. The data will also be used to test the new severity classification system for exacerbations of COPD, as well as to determine important relationships between physiological measurements from the wearable devices, the handheld oscillometer, … |
BRYAN A. ROSS; | 2025-02-10 |
| 51 | Effects of Diaphragmatic Breathing and Relaxation Exercises in Patients with Gastroesophageal Reflux PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to examine the effects of diaphragmatic breathing exercises combined with relaxation exercises on patient-reported reflux symptoms, quality of life, anxiety, and depression levels in patients diagnosed with gastroesophageal reflux. |
TARIK OZMEN; | 2025-02-03 |
| 52 | Chronic Airway Disease and Miltimorbidity （CAM） Cohort: Protocol of A Prospective Multicenter Observational Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis, are highly prevalent and cause serious disease burden. Multimorbidity is recognized to influence treatment decision and prognosis of patients with stable CAD. The impact of multimorbidity on exacerbation CAD is under investigated. Methods: The Chronic Airway Disease and Miltimorbidity (CAM) cohort study is a prospective, multicenter, observational study aiming to recruit a minimum of 2000 patients hospitalized for exacerbation of COPD, asthma or bronchiectasis. Comprehensive data, including demographics, medical history, comorbidities, lung function, echocardiography, microbiological profiles, radiology, … |
TING YANG; | 2025-02-01 |
| 53 | Metoprolol in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the clinical trial was to see if Metoprolol was effective in treating patients with heart failure and chronic obstructive pulmonary disease. It will also learn about the safety of Metoprolol. The main questions it aims to answer are: Did Metoprolol reduce the frequency of all-cause deaths and re-hospitalizations in subjects? What medical problems do participants experience after taking Metoprolol? The researchers will compare different doses of Metoprolol to see the best dose for Metoprolol. Participants will: Take Metoprolol 23.75mg/ day or the maximum tolerable dose of Metoprolol daily for 24 months. Regular outpatient follow-up visits to the research center. Their symptoms and Metoprolol dosage were recorded. |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2025-02-01 |
| 54 | OM 85 to Prevent Respiratory Infections in Older At Risk Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: People living in NH are at higher risk of respiratory infections compared to their counterpart living in the community. Products obtained from dead bacteria (bacterial lysate) can be used to boost immune system and may reduce the risk of respiratory infections. Very little information is available on the effect of these substances in older people. This study will evaluate the efficacy of a bacterial lysate in reducing the incidence of lower respiratory tract infections in older people living in nursing homes. The study will include a treatment arm, in which participants will received the lysate, … |
RAFFAELE ANTONELLI INCALZI; | 2025-02-01 |
| 55 | Prospective Multicentric Cohort Study of Severe and Very Severe COPD Patients in Brazil PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Observational, prospective, multicenter cohort study with consecutive inclusion of COPD patients. Eligible patients will be those with severe and very severe COPD according to the GOLD 2024 (Global Initiative for Chronic Obstructive Lung Disease) guidelines being followed at participating hospitals. The severity of COPD is related to the exacerbation rate, which in turn is related to the progression of the disease and the occurrence of complications and death. There is no national data on this subgroup. |
ASTRAZENECA | 2025-01-31 |
| 56 | Comparative Study of Escalating PEEP (Positive End Expiratory Pressure) Vs. Lung Recruitment By Sustained Inflation Strategies for Managing Hypoxemia in COPD Patients Undergoing Video-Assisted Thoracoscopic Surgery (VATS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates and compares the effectiveness of two distinct ventilation strategies-escalating PEEP and lung recruitment maneuvers-in improving oxygenation (i.e., managing hypoxemia) in COPD patients undergoing VATS. |
AIN SHAMS UNIVERSITY | 2025-01-30 |
| 57 | Detecting Systemic Carbon Dioxide Levels With A Novel Biosensor; The DISCO-study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is an open, prospective, single center clinical observational pilot investigation. The aim is to compare the carbon dioxide values measured by the IscAlert sensor, which is inserted in proximity to the nasal mucosa. The study wants to investigate if the nasal mucosa application and measurements are feasible, what kind of possible complications such a measurement can cause, and if the measurements can be a surrogate marker for systemic carbon dioxide values. |
ANNE-MARIE GABRIELSEN; | 2025-01-30 |
| 58 | Validity and Reliability of The Six-minute Peg Board and Ring Test in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to evaluate the validity and reliability of 6-PBRT in patients with rheumatoid arthritis and to determine the applicability of the test for this population. |
BAŞAK KAVALCI KOL; | 2025-01-26 |
| 59 | Chronic Effect of Whole-body Electrical Stimulation in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized clinical trial. Patients with chronic obstructive pulmonary disease (COPD) GOLD III or IV will undergo 16 sessions of Whole-body Electrical Stimulation (WB-EMS) or pulmonary rehabilitation (PR), twice a week. WB-EMS will be performed in association with squats, biceps and triceps exercises, climbing up and down a step, … |
JOCIANE SCHARDONG; | 2025-01-20 |
| 60 | Validity and Reliability of The Six-minute Peg Board and Ring Test in Patients With Chronic Neck Pain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to evaluate the validity and reliability of six-minute peg board and ring test (6-PBRT) in individuals with chronic neck pain and to determine the applicability of the test for this patient population. |
BAŞAK KAVALCI KOL; | 2025-01-20 |
| 61 | Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent. Also, SDB shows high comorbidities with multisystem diseases. Furthermore, compared to patients with pure SDB, those comorbid with SDB and other disorders like cardiometabolic dysfunction and cognitive impairment experience poorer quality of life, higher rate of disease progression and mortality, and a greater economic burden. Currently, … |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2025-01-15 |
| 62 | Two-part, Single-dose, Dose-finding Study to Assess The Safety, Tolerability, Pharmacokinetics and Bronchodilator Effects of AERO-007 Inhalation Solution Using A General Purpose Nebulizer in Healthy Volunteers and Subjects With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 1/phase 2a, single dose, crossover study conducted in two parts. Part 1: Phase 1, open-label, 4-period crossover study in 8 healthy subjects to determine the optimal dose of AERO-001 and AERO-002, the active components of AERO-007 combo bronchodilator, using the systemic pharmacokinetic (PK) profile. Part 2: Phase 2a, randomized, double-blind, placebo-controlled, 3-period crossover study in 16 subjects with COPD to determine the safety, tolerability, PK, and bronchodilator profile of AERO-007 inhalation solution administered via oral inhalation using a general-purpose nebulizer. |
DAVE SINGH; | 2025-01-15 |
| 63 | The Respiratory Oxygen Adherence Monitor System for COPD With Long Term Oxygen Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to test a device being developed that can see how patients use oxygen therapy over a long period of time. This study will focus on developing a new display part called ROAM module which will be attached to your oxygen source. The display will provide easily-accessible information that can show how you interact with your supplies and the oxygen machine automatically without connecting the oxygen source to the internet or other devices. |
Y. MICHAEL SHIM; | 2025-01-14 |
| 64 | Preoxygenation for Tracheal Aspirations in Intensive Care, A Randomized Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Clearing the airways is a complex phenomenon involving the production of secretions, the nature of mucus (viscosity, elasticity, stringiness, and adhesiveness), ciliary movement, and coughing. In intubated and ventilated patients, endotracheal suctioning occur when the patient is unable to clear the airways of obstructions hindering the free passage of air. These suctioning can lead to transient desaturation exacerbated by a decrease in cardiac output due to increased mean arterial pressure, promoting cardiac arrhythmias. To minimize these effects, it is recommended to perform additional preoxygenation, … |
CLAIRE FAZILLEAU; | 2025-01-07 |
| 65 | A Digital Health Intervention for Promoting Self-management in Patients with Chronic Obstructive Pulmonary Disease – A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnea, cough, and chronic mucus hypersecretion are common symptoms in patients with Chronic Obstructive Pulmonary Disease (COPD), which increases risk of infections followed by exacerbations, often leading to hospitalization, … |
BENTE FRISK; | 2025-01-06 |
| 66 | A Mobile Integrated Health Intervention for The Management of Acute-phase Exacerbation of Congestive Health Failure and Chronic Obstructive Pulmonary Disease Related Papers Related Patents Related Grants Related Experts View Highlight: Episodic and disjointed medical care for older, community-dwelling adults with chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) leave them vulnerable to adverse events such as worsening disease trajectories, frequent emergency department (ED) utilization, and avoidable hospital admissions. It is imperative that an alternative means of health delivery be developed, establishing a coordinated, … |
LAUREL O’CONNOR; | 2025-01-01 |
| 67 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Clinical Study to Evaluate The Efficacy, Safety, and Pharmacokinetics of TQC2731 Injection in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and safety of TQC2731 injection in patients with moderate to severe chronic obstructive pulmonary disease. |
SHANGHAI CHIA TAI TIANQING PHARMACEUTICAL TECHNOLOGY DEVELOPMENT | 2024-12-31 |
| 68 | Respiratory Syncytial Virus Infection in Exacerbations of Chronic Obstructive Pulmonary Diasease: The RECODE Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to determine the prevalence of respiratory syncytial virus (RSV) infection and evaluate its association with clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) who experience exacerbations during the RSV season (October-April). The main question it aims to answer is: * What is the prevalence of RSV infection in patients with COPD during exacerbations in the RSV season? * Does RSV infection lead to worse clinical outcomes, including hospitalization, longer length of stay, acute cardiovascular events, … |
FUNDACIO PRIVADA MON CLINIC BARCELONA | 2024-12-16 |
| 69 | Investigation of The Validity and Reliability of 6-minute Pegboard and Ring Test in Patients With Interstitial Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Interstitial lung diseases (ILD) are a heterogeneous group of chronic respiratory diseases that cause significant mortality and morbidity worldwide, characterized by diffuse inflammation in the lung parenchyma and vascular structures, can progress to fibrosis, have known or unknown etiology, and can develop secondary to systemic autoimmune connective tissue diseases other than diseases where the primary pathology is in the lung. The 6-minute peg-board and ring test, which was first developed to determine the upper extremity exercise capacity of chronic obstructive pulmonary disease patients, … |
MERAL BOŞNAK GÜÇLÜ; | 2024-12-12 |
| 70 | Comparison of Exercise Capacity, Muscle Oxygenation and Physical Activity Levels Between Patients With Interstitial Lung Disease and Healthy Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Interstitial lung diseases (ILD) are a group of chronic respiratory diseases that cause significant mortality and morbidity worldwide. Although there are studies in the literature comparing different lung disease groups with healthy individuals, it has been determined that there is no study comparing the exercise capacity, muscle oxygenation, physical activity level, respiratory functions, respiratory and peripheral muscle strength, inspiratory muscle endurance, quality of life and sleep quality of individuals diagnosed with ILD with healthy individuals. |
MERAL BOŞNAK GÜÇLÜ; | 2024-12-12 |
| 71 | Can Total Mechanical Power Be A Determinant of Weaning Failure in Chronic Obstructive Pulmonary Disease (COPD)? PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A Comparison of Ventilator Parameters (TV, DP, Total Mechanical Power, etc.) Between Successfully and unsuccessfully Weaned Patients with COPD Undergoing Mechanical Ventilation Due to Respiratory Failure, and Diagnosed with Pneumonia or ARDS in the Intensive Care Unit. |
BAKIRKOY DR SADI KONUK RESEARCH AND TRAINING HOSPITAL | 2024-12-06 |
| 72 | The Effect of Flipped Learning on Nursing Students’ Knowledge and Skills of Inhaler Drug Administration PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In the study, it was aimed to evaluate the effect of inverted classroom teaching method on nursing students’ inhaler drug application knowledge and skills. |
BILECIK SEYH EDEBALI UNIVERSITESI | 2024-12-01 |
| 73 | Effect of FAST HUGS WITH ICU Approach on Length of Intensive Care Unit Stay in Patients With Hypoxic Respiratory Failure: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the effect of the FAST HUGS WITH ICU approach on the length of stay in the intensive care unit in patients with hypoxic respiratory failure. Patients will be randomly assigned to the experimental and control groups. The standard procedure will be applied to the control group. The FAST HUGS WITH ICU approach will be applied to the experimental group. We plan to follow up patients with Hypoxic Respiratory Failure using the abbreviation FAST HUGS WITH ICU (Feeding, Analgesia, Sedation, Thromboembolic prophylaxis, Head of bed elevation, Stress Ulcer prophylaxis and Glucose control Spontaneous breathing trial, … |
GAMZE KOÇ; | 2024-12-01 |
| 74 | Observation Study on The Efficacy of Yiqi Gubiao Pill in The Treatment of Chronic Obstructive Pulmonary Disease Secondary to Active Pulmonary Tuberculosis: A Double-Blind Randomized Controlled Trial Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis-related obstructive pulmonary disease (TOPD), as a high-burden disease in most countries, poses difficulties in the diagnosis and treatment of the disease when coexisting, and increases the risk of death for patients. Preliminary studies have shown that Yiqi Gubiao Wan has significant effects in relieving cough, alleviating asthma, expectorating phlegm, and delaying airway obstruction. The purpose of this study is to verify the therapeutic effect of Yiqi Gubiao pill on patients with TOPD through rigorous methodological design and to evaluate its safety. We will conduct a prospective, double-blind, randomized controlled trial. First, … |
JIN DAI; | 2024-11-30 |
| 75 | A Prospective, Multicenter, Self-controlled Clinical Trial to Validate Optical Ultrasonic Flow Ratio (OUFR) Based on Intravascular Imaging PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of is study is to validate a novel computational Fractional Flow Reserve (FFR) index method, termed Optical Ultrasonic Flow Ratio (OUFR), based on intravascular imaging including intravascular optical coherence tomography (OCT) and intravascular ultrasound (IVUS), using wire-based FFR as the gold standard. This is a prospective, multi-center, self-controlled clinical trial involving at least four medical centers and recruiting at least 114 subjects based on statistical power analysis. Participants undoing anticipated percutaneous coronary intervention will be performed: 1. Wire-based FFR measurement 2. Intravascular imaging, … |
YU BO; | 2024-11-10 |
| 76 | Bronchodilators and Dynamic Lung Mechanics During Exercise in COPD: Protocol for A Randomised, Placebo-controlled Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchodilators are medications that open the bronchi to help patients with COPD to breathe better. It is still not known exactly how this effect improves shortness of breath in people with COPD. The goal of this clinical trial is to determine whether bronchodilators lower resistance in the smallest airways in the lungs, and whether this will improve the feeling of breathlessness in these patients. The main questions the investigators attempt to answer are: * In patients with COPD, does treatment with a short-acting bronchodilator improve small airway resistance during exercise? * In patients with COPD, … |
J. ALBERTO NEDER; | 2024-11-10 |
| 77 | Expanding Pulmonary Rehabilitation in Other Chronic Respiratory Disease Than COPD – The ExPuRe Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this pilot randomized clinical trial is to evaluate the willingness, acceptance, adherence and signs of benefits of structured home-based pulmonary rehabilitation (HPR) and supervised pulmonary tele-rehabilitation (PTR) on respiratory symptoms, quality of life, functioning and physical activity in patients with ILD (Interstitial lung disease, Idiopathic pulmonary fibrosis, Sarcoidosis), … |
HENRIK HANSEN; | 2024-11-01 |
| 78 | Feasibility Study of Telerehabilitation for People with Chronic Obstructive Pulmonary Disease in Nuuk: Evaluation and Adaptations for Future Rollout Across Greenland PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease, or COPD, is a major global health issue. It can make people ill, impact their quality of life, and increase their use of healthcare services. In some parts of Greenland, it can be particularly challenging to manage COPD due to the distance to healthcare assistants, nurses, or doctors. Telerehabilitation, which allows people to receive treatment online, could be a good solution. This project aims to explore how we can best support COPD patients in Nuuk through an online rehabilitation program. The program functions as a pilot study, … |
STENO DIABETES CENTER GREENLAND | 2024-11-01 |
| 79 | Analyzing Acoustic Properties of The Vowel a Collected Via Mobile Phone From Individuals Diagnosed With Chronic Obstructive Pulmonary Disease and Health Control Groups PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Study aims to identify the changes in voice caused by Chronic Obstructive Pulmonary Disease (COPD) statistically for identifying the potential digital voice biomarkers. |
BLEKINGE INSTITUTE OF TECHNOLOGY | 2024-10-28 |
| 80 | Comparative Study on Respiratory Muscle Strength and Exercise Capacity in Smokers with COPD, PRISm and Pre-COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This cross-sectional study aims to evaluate the respiratory muscle strength and physical capacity of symptomatic adult smokers in Muğla. The study population will be the patients who were admitted to the pulmonary outpatient clinic of Muğla Training and Research Hospital between July 2024 and December 2024. The primary outcome is the proportion of individuals with Maximum Inspiratory Pressure (MIP) below 80%. Secondary outcomes include the 6-Minute Walk Test (6MWT) distance, Maximum Expiratory Pressure (MEP), and COPD Assessment Test (CAT) scores. Smokers will be categorized into COPD, PRISm, … |
SABRI SERHAN OLCAY; | 2024-10-20 |
| 81 | Relationship Between CAT Score and Airway Limitation in Adult Smokers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to show the relationship between CAT Score and airway limitation in smokers who applied to MSKU Chest Diseases Polyclinic with respiratory complaints (shortness of breath, cough, sputum, etc.) and underwent respiratory function tests. CAT Score is a measurement used to evaluate the quality of life of Chronic Obstructive Pulmonary Disease (COPD) patients. CAT Score is a scale used to assess patients’ symptoms (such as shortness of breath, cough, and sputum) and problems affecting their daily activities. CAT Score usually takes a value between 0 and 40, … |
SABRI SERHAN OLCAY; | 2024-10-12 |
| 82 | Experiential Learning and Critical Thinking: An Exploration of The Learning Effectiveness of Using Situational Case Videos in The Application of Emergency Nursing Course PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized controlled trial. The goal of this clinical trial is to introduce scenario-based case videos into the elective course of Emergency Nursing and Applications for first-year students in a two-year program. By using five typical scenario-based case videos, the aim is to guide students through experiential learning and critical thinking, overcome learning difficulties, increase learning interest, and enhance learning outcomes. The main aims of this research are: To explore the effectiveness of emergency scenario-based case teaching on students learning focus, knowledge acquisition, classroom participation, … |
CHIA-CHI KUO; | 2024-10-03 |
| 83 | Efficacy and Safety of 0.5% W/v Nano- Silver Nitrate Versus Silver Nitrate Solution for Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema: Prospective Interventional Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Emphysema is a progressive phenotype of chronic Obstructive Pulmonary Disease (COPD), poses a significant global health burden characterized by irreversible lung parenchymal destruction and airspace enlargement. In recent years, bronchoscopic lung volume reduction (BLVR) has considerable interest as a minimally invasive approach to reducing hyperinflation and improving lung function in patients with emphysema. BLVR techniques aim to achieve lung volume reduction by occluding or ablating emphysematous lung tissue through endobronchial delivery of various agents. Many techniques are available for BLVR as coil, endo-bronchial valve, and biological as thrombin, autologous blood and chemicals as silver nitrate solution. |
MOHAMED ABD ELMONIEM MOHAMED; | 2024-10-01 |
| 84 | The Increase of Lung Capacity Using The Lung Master (Pulmonary Exerciser) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators are studying how a device called The Lung Master device can help people breathe better. The investigational device increases the amount of air our lungs can hold, which is important for overall lung health. The Lung Master is not approved by the FDA. The study has two visits approximately one month apart. In the first visit participants will take a spirometry test, particularly forced vital capacity (FVC), to measure volume change in the lungs. Participants will take the investigational device home to use daily, … |
FARAHNAZ FALLAH TAFTI; | 2024-10-01 |
| 85 | A Randomized, Safety and Efficacy Study of Taneasy 600mg Granules and Actein Effervescent Tablets 600MG in COPD Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and efficacy of Taneasy 600mg granules and Actein effervescent tablets 600MG administered twice daily for 14 days in treatment of COPD Disease. |
BUN YAO BIOTECHNOLOGY | 2024-09-20 |
| 86 | Chronicling The COPD Patient Journey and Change in Impact of A Single Inhaler Combination Therapy on COPD Symptoms, Quality of Life and Exacerbations Following Initiation of Budenoside/Glycopyrronium/Formoterol [BGF](CHRONICLES COPD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The CHRONICLES study will investigate the change in clinical and patient reported outcomes after six-months of treatment with Budenoside/Glycopyrronium/Formoterol \[BGF\] in a real-world setting. |
CHRISTOPHER JAMES LICSKAI; | 2024-09-17 |
| 87 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial of The Efficacy and Safety of Inhaled TQC3721 Suspension in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy and safety of TQC3721 Suspension for Inhalation in patients with moderate to severe Chronic obstructive pulmonary disease (COPD) |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2024-09-14 |
| 88 | Effects of Isometric Hand Grip Exercise Training on Lung Function in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a preventable and treatable lung disease. People with COPD must work harder to breathe, which can lead to shortness of breath and/or feeling tired. Early in the disease, people with COPD may feel short of breath when they exercise. As the disease progresses, it can be hard to breathe out (exhale) or even breathe in (inhale). A person with COPD may have obstructive bronchiolitis emphysema, or a combination of both conditions. There is variety of treatment like breathing exercises, inspiratory muscle training exercises, … |
DANISH HASSAN; | 2024-09-01 |
| 89 | Association Between Cardiopulmonary Function, Mobility, Walking Ability, and Plantar Pressure Changes in Patients With Chronic Obstructive Pulmonary Disease: A Case-Control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It aims to understand the differences in everyday mobility and activity capabilities among patients with varying disease progression and severity, to serve as reference indicators for evaluating the effectiveness of pulmonary rehabilitation exercise training. |
KE-YUN CHAO; | 2024-09-01 |
| 90 | Effects Of Circuit Training and Progressive Resistance Exercise Program On Pulmonary And Physical Parameters In COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is characterized by a combination of pulmonary and extra-pulmonary manifestations that directly contribute to the increase in exercise intolerance and dyspnea, especially in more advanced stages of the disease, leading to physical inactivity and consequent worsening of these signs and symptoms. COPD is a preventable and treatable lung disease. Solid evidence shows that physical training, the most important component of a Pulmonary Rehabilitation program (PR), reduces dyspnea and fatigue, increases exercise performance, and improves peripheral muscle strength, functional capacity, … |
ZUBAIR KHALID; | 2024-08-30 |
| 91 | Anesthetic Management in Patients Undergoing Epicardial Ablation for The Treatment of Ventricular Tachycardia; Retrospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a retrospective study and is descriptive in nature. In this study, the investigators aimed to emphasize the importance of anesthesia management by cardiac risk assessment of patients undergoing epicardial ablation under general anesthesia and analysis of complications that developed during the procedure. |
FERDA YAMAN; | 2024-08-30 |
| 92 | A Phase IIb, Randomized, Double-blind, Placebo-controlled Study to Assess The Efficacy, Safety, and Pharmacokinetics of Glycopyrrolate Inhalation Solution Over 1 Week in Subjects With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, double-blind, placebo-controlled complete block cross-over study designed to assess the efficacy, safety, and pharmacokinetics of 3 dose levels of glycopyrrolate inhalation solution delivered twice daily via standard jet nebulizer over three 1-week active treatment periods and one 1-week placebo period in subjects with chronic obstructive pulmonary disease (COPD). |
VERONA PHARMA PLC | 2024-08-16 |
| 93 | Effects of Breathing Exercises With and Without Inspiratory Muscle Training on Dyspnea, Lung Volumes and Lung Capacities in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a major health issue that affects a large proportion of the population, especially those over 50 years old. It is characterized by breathlessness and reduced lung function. It has been hypothesized that practicing specific breathing exercises could potentially alleviate these symptoms and enhance lung volumes and capacities. In addition, there is a lack of clarity on the effects of inspiratory muscle training along with these breathing exercises, warranting further investigation. To determine the effects of breathing exercises with and without inspiratory muscle training on dyspnea, … |
SIDRA AFZAL; | 2024-08-15 |
| 94 | A Randomized, Double-blind, Placebo-controlled, Multiple Dose-Ranging Study to Assess The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Solrikitug in Participants With Chronic Obstructive Pulmonary Disease (ZION) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Randomized, Double-blind, Placebo-controlled, Multiple Dose-Ranging Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Solrikitug in Participants with Chronic Obstructive Pulmonary Disease (COPD). |
UNIQUITY ONE UNI | 2024-08-14 |
| 95 | Breathing New Life: The Impact of Incentive Spirometer Training on Rehabilitation and Health in Type 2 Diabetes With Sarcopenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In patients with Type 2 diabetes, the risk of developing sarcopenia is three times higher compared to individuals with normal blood sugar levels. Sarcopenia is often accompanied by reduced physical activity, immobility, slow gait, and poor endurance. More importantly, previous studies have shown that sarcopenia leads to a decrease in mobility, which in turn results in reduced cardiopulmonary function, difficulty in breathing, and subsequently even less activity. In diabetic patients, this can cause poor control of blood sugar and lipids, as well as sarcopenic obesity, creating a vicious cycle. Therefore, … |
YU-SHAN HSIEH; | 2024-08-01 |
| 96 | Effect of Breather on Ventilatory and Vascular Function in Chronic Obstructive Pulmonary Disease Patients With Intermittent Claudication PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study To show the effect of breather on ventilatory and vascular function in COPD patient with intermittent claudication. |
REEM MEDHAT MOHAMED ALI FARAHAT; | 2024-08-01 |
| 97 | The Effect of Body Composition on Respiratory Parameters, Functional Capacity and Sleep in Healthy Young Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Body composition has a significant effect on the respiratory system. Both respiratory prediction of function and a prognostic tool evaluated in the cardiopulmonary system factor. Respiratory function, which directly affects respiratory muscle strength and respiratory muscle endurance covers a range of data. In the literature, the relationship between body composition and respiratory function. Although there are studies examining body composition in healthy young adults, the relationship between them has not been clearly demonstrated. The aim of the study was to investigate the effects of body composition on respiratory function, respiratory muscle endurance, functional capacity and sleep quality. For this purpose, … |
MELIS USUL; | 2024-08-01 |
| 98 | Extra-Corporeal Carbon Dioxide Removal for Acute Decompensation of Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial (The ORION Study) Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, resulting in a social and economic burden that is substantial and increasing. Exacerbations affect the prognosis and quality of life of patients with COPD. Hospital mortality of patients admitted for a hypercapnic exacerbation of COPD is approximately 10% and the long-term outcome is poor. In addition, hypercapnic exacerbation of COPD have serious negative impacts on patient quality of life, lung function and costs. Thus, … |
V. MARCO RANIERI; | 2024-08-01 |
| 99 | Effects of Senobi Exercises Versus Jacobsons Muscular Relaxation Exercises on Pulmonary Functions, Dyspnea, and Sleep Quality in Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to evaluate the effects of Senobi versus Jacobsons muscular relaxation exercises on pulmonary functions, dyspnea, and sleep quality in chronic obstructive pulmonary disease. The study design will be a randomized clinical trial. The study will be completed in 10 months after the approval of the synopsis from the Ethical Committee of RCRS and AHS. A non-probability convenient sampling technique will be used to recruit the individuals into two groups. Group A had undergone Senobi exercises and Group B engaged in Jacobsons Muscular relaxation exercises along with conventional treatment of COPD. |
TASNEEM SHEHZADI; | 2024-07-25 |
| 100 | A Randomized Controlled Trial on Exercise Program in Patients With Nontuberculous Mycobacterial Pulmonary Disease (NTM-Exercise) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1.objective Evaluation of effectiveness and safety of exercise intervention program for patients with non-tuberculous mycobacterial pulmonary disease 2. background Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic respiratory infection that generally affects individuals with structural lung diseases, such as chronic obstructive pulmonary disease (COPD) and bronchiectasis and without structural lung disease. The prevalence of NTM-PD is increasing worldwide , … |
YONSEI UNIVERSITY | 2024-07-24 |
| 101 | Pulmonary Diffusing Capacity During Incremental Exercise in COPD: A Case-Control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The combined measurement of pulmonary diffusing capacity for carbon monoxide (CO) and nitric oxide (NO) (DL,CO,NO) has recently been standardized and validated for clinical use. It involves a noticeably short breath-hold time (≤5 seconds), making it feasible to perform on patients with chronic obstructive pulmonary disease (COPD). These patients have lower diffusing capacity and are unable to increase it during exercise, … |
MILAN MOHAMMAD; | 2024-07-15 |
| 102 | Clinimetric Properties of Performance-based Measures of Physical Function in Patients With COPD: A Comparison of Clinimetric Properties of Four Tools PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A COPD (Chronic obstructive pulmonary disease), is a group of progressive lung diseases. COPD is a preventable and treatable respiratory disorder largely caused by smoking and long term exposure to chemical irritants. This study aims to provide essential insights into the reliability, validity, responsiveness and Interpretability of such tests, enabling healthcare professionals to make informed decisions about patient recovery progress and the optimization of rehabilitation protocols. |
SUMAN SHERAZ; | 2024-07-15 |
| 103 | Effects of An Educational Intervention Program on Lung Function and Ergonomic Hazards Among Marble Factory Workers: Quasi-experimental Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Marble cutting exposes workers to dust, increasing risk of lung diseases like asthma, COPD, silicosis, and asbestosis. Many marble cutters in rural areas lack awareness of these risks and work without proper protection. Khyber Pakhtunkhwa has over 4000 marble factories employing over a million laborers, mostly unskilled and vulnerable. Workers face health risks from heavy lifting, poor posture, and respirable dust. Ergonomic disorders are also common due to poorly designed workstations, repetitive motions, and straining postures. Musculoskeletal Symptoms (MSS) can progress into Musculoskeletal Disorders (MSDs), … |
SUMAN SHERAZ; | 2024-07-15 |
| 104 | The Relation Between Atopy and Frequency of Exacerbation in Chronic Obstructive Pulmonary Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production and/or exacerbations) due to abnormalities of airways (bronchitis, bronchiolitis) and/or alveoli (emphysema) that cause persistent, often progressive, airflow obstruction. The presence of non-fully reversible airflow obstruction (FEV1/FVC < 0.7 post-bronchodilation) measured by spirometry confirms the diagnosis of COPD |
MOHAMED ABD ELMONIEM MOHAMED; | 2024-07-14 |
| 105 | An Open-label Phase II Study to Assess The Pharmacodynamic (PD) Effects of Dexpramipexole in Participants with Eosinophilic Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label Phase II study assessing the PD of dexpramipexole 150 mg twice daily (BID) in participants with eosinophilic COPD. This study will help characterize the profile and duration of reductions of blood absolute eosinophil counts (AEC). |
GERARD J CRINER; | 2024-07-09 |
| 106 | A 12-Week Single-Cohort Study, to Evaluate Real-World Effectiveness of A Triple Combination Beclometasone Diproprionate/Formoterol Fumarate/Glycopyrronium Bromide (BDP/FF/GB) in A Single Pressurised Metered Dose Inhaler (Trimbow® PMDI) in Subjects With COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate Real-World Effectiveness of a Triple Combination Beclometasone Diproprionate/Formoterol Fumarate/Glycopyrronium Bromide (BDP/FF/GB) in a Single Pressurised Metered Dose Inhaler (Trimbow® pMDI) in Subjects with Chronic Obstructive Pulmonary Disease (COPD). |
JINPING ZHENG; | 2024-07-02 |
| 107 | Exploration and Study on The Identification of Various Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) marker molecules. This model aims to accurately diagnose mutiple pulmonary diseases. The primary objectives it strives to accomplish are: 1. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose several common pulmonary diseases. 2. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose more pulmonary diseases. |
CHROMX HEALTH | 2024-06-30 |
| 108 | The Effect of Empowerment Model-Based Telenursing Interventions in Empowering Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the effect of telenursing interventions based on the empowerment model in empowering patients with COPD. |
ZAHIDE AKSOY; | 2024-06-25 |
| 109 | The Effect of Video-Based Breathing Exercises Taught to COPD Patients on Dyspnea Severity, Activity Level, and Sleep Quality PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is one of the most prevalent and high-mortality chronic diseases worldwide. Symptoms such as dyspnea, cough, sleep disturbances, fatigue, restricted activity levels, anxiety, and depression develop in COPD patients, negatively affecting their quality of life. Dyspnea, associated with various symptoms in COPD patients such as reduced activity levels and sleep disturbances, is a significant issue. Therefore, effective management of dyspnea will contribute to reducing other important problems associated with COPD. One of the non-pharmacological methods used in managing these symptoms associated with COPD is breathing exercises. Particularly, … |
AYFER BAYINDIR ÇEVIK; | 2024-06-20 |
| 110 | The Effect of Stress Ball on Pain, Anxiety and Physiological Parameters in COPD Patients Receiving Noninvasive Mechanical Ventilation Support PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomised controlled trial was to investigate the effect of a stress ball on pain, anxiety and physiological parameters in Chronic Obstructive Pulmonary Disease (COPD) patients on non-invasive mechanical ventilation (NIMV). |
HUSEYIN SEKER; | 2024-06-15 |
| 111 | Assessing The Efficacy of Dexmedetomidine in Alleviating Agitation for Exacerbated COPD Patients Who Are Treated for Psychosis Requiring Non- Invasive Ventilation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Many studies approved dexmedetomodine as a drug controlled agitation for psychotic patients and also for patients on non invasive ventilation. So we study the same effect on agitated patients who are on non invasive ventilation and also suffer of psychosis as agitation become more aggressive than usual |
MOHAMED ZAKAREA WFA; | 2024-06-10 |
| 112 | Anti-Inflammatory Reliever Therapy for Asthma Using Inhaled Budesonide/Formoterol As-needed With or Without Maintenance in South African Children: A Pragmatic Open Label Phase 3 Randomised Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 3 single-centre open label randomised controlled trial with two equal sized groups to assess the efficacy of budesonide/formoterol 80/4.5 (6-11 years) and 160/4.5 (12-18 years) compared to the standard of care in reducing asthma exacerbations over 52 weeks. Children and adolescents with a diagnosis of asthma or newly diagnosed with asthma will be screened for eligibility for enrolment. Those who had an asthma exacerbation in the previous year will be randomised 1:1, to either receive budesonide/formoterol inhaler for both symptom relief and for chronic anti- … |
UNIVERSITY OF KWAZULU | 2024-06-06 |
| 113 | The Effect of Combined High Intensity Interval Training and Inspiratory Muscle Training on Pulmonary Function and Exercise Capacity in COPD Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the effect of combined high intensity interval training (HIIT) and inspiratory muscle training (IMT) on pulmonary function and exercise capacity in patients COPD. one hundred patients with COPD (GOLD II and III) with ages between 40 and 70 years participated in this study. The main question it aims to answer is whether combined high intensity interval training (HIIT) and inspiratory muscle training (IMT) have effect on pulmonary function and exercise capacity Pulmonary function tests, incremental cycle ergometer tests, … |
AHMAD SAIED MOHAMMAD; | 2024-06-01 |
| 114 | ESPEN-EASO Sarcopenic Obesity (OS) Diagnostic Criteria Application in A COPD Cohort and OS Correlation to Diaphragmatic Thickness and Mobility for Determination of Tailored Pulmonary Rehabilitation Program: An Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to the purpose is to apply of ESPEN/EASO criteria for the diagnosis of sarcopenic obesity and calculation of OS prevalence in a sample of COPD patients. In addition, this study want to evaluate the impact of sarcopenic obesity on the respiratory function of COPD patients and the degree of severity of respiratory disease, assessed by spirometric examination; diaphragm thickness and excursion, by ultrasonographic study; performance, assessed by six-minute walk test (6-MWT); quality of life and degree of dyspnea (mMRC, Barthel dyspnea, S. George Respiratory Questionnaire); … |
IRCCS SAN RAFFAELE ROMA | 2024-06-01 |
| 115 | Exploring The Motivational Enhancement Therapy’s Impact on Motivation, Resilience, Anxiety Reduction, and COPD Outcomes in Geriatric Patient PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Motivational Enhancement Therapy (MET) is a systematic intervention that focuses on eliciting and strengthening a person’s intrinsic motivation to change. MET is rooted in motivational interviewing principles, emphasizing empathy, autonomy, and the evocation of the patient’s own motivations for change. The therapy typically involves several sessions where therapists help patients identify personal goals, explore ambivalence towards change, and develop actionable plans to achieve their desired outcomes. |
MOHAMED H ATTA; | 2024-06-01 |
| 116 | Frequency-time Analysis of Pathological Lung Sounds: Detection and Quantification of Pathological Sounds in Patients With Cystic Fibrosis, Pulmonary Fibrosis or COPD (Chronic Obstructive Pulmonary Disease) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to assess the potential of time-frequency representation and analysis of pulmonary sounds collected with an electronic stethoscope, as part of the routine monitoring of patients with cystic fibrosis, COPD or pulmonary fibrosis. |
GROUPE HOSPITALIER DE LA REGION DE MULHOUSE ET SUD ALSACE | 2024-06-01 |
| 117 | Impact of Breathing Exercises on Lung Function in Chronic Airway Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: aim of this study is to evaluate the efficacy of pulmonary rehabilitation program as a non-pharmacological treatment method to: Improve functional capacity as assessed by six-minute walking distance (6MWD) test. Improve dyspnea level as assessed by Medical Research Council (MRC) dyspnea scale. Improve pulmonary function tests and arterial blood gas. |
MOHAMED ABD ELMONIEM MOHAMED; | 2024-06-01 |
| 118 | EXACERBATIONS AND REAL-WORLD OUTOMES INCLUDING CARDIOPULMONARY EVENTS AMONG PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE INITIATING BUDESONIDE/GLYCOPYRRONIUM/FORMOTEROL (MITOS: EROS+CP US Study) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: A retrospective real-world data study, assessing the relationship between the timing of Budesonide/Glycopyrrolate/Formoterol initiation following an exacerbation and the occurrence of subsequent exacerbations, severe cardiopulmonary events and other real-world outcomes in the United States |
ASTRAZENECA | 2024-05-31 |
| 119 | Multi-Center Clean Air Randomized Controlled Trial in COPD PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing COPD exacerbation risk and improving quality of life, functional status, rescue medication use. |
STEPHAN EHRHARDT; | 2024-05-24 |
| 120 | Using Large Language Models Such As GPT-4 to Assess Guideline Adherence in Patients with Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: According to studies in the US and the Netherlands, 33-40% of patients with chronic conditions receive care that does not follow guideline recommendations. These findings have also been demonstrated in the management of COPD. This leads to under- or over-treatment of patients and, in the case of COPD, to exacerbations and hospitalisations. These exacerbations are a significant clinical problem, affecting patient’s lung function, quality of life and mortality. They are also a burden on the healthcare system. Technological advances in artificial intelligence offer the opportunity to address these issues in COPD management. In the past year, … |
MATTHIAS GRÖSCHEL; | 2024-05-15 |
| 121 | The Impact of COPD on Psychological Well-being: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) can significantly impact a person’s quality of life, not only physically but also mentally. This cross-sectional study aims to assess the psychological well-being of COPD patients by utilising specific questionnaires. These questionnaires will evaluate various aspects of mental health, including anxiety, depression, and potentially other relevant factors like self-compassion or fear of negative evaluation, self-efficacy, shame, and guilt. Additionally, the study will examine how these psychological factors relate to the severity of COPD symptoms, such as dyspnea and functional limitations. By understanding the psychological impact of COPD, … |
CRISAN ALEXANDRU FLORIAN; | 2024-05-13 |
| 122 | Exploring Muscle Proprieties in COPD: A Non-invasive Evaluation of Respiratory and Limb Muscle Mechanics Using Myotonometry PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine if patients with Chronic Obstructive Pulmonary Disease (COPD) exhibit altered muscle properties (specifically changes in tone and stiffness) in both their respiratory muscles and skeletal muscles when compared to healthy individuals. The study will utilize the Myotonometer, a non-invasive device, to assess these properties. |
CRISAN ALEXANDRU FLORIAN; | 2024-05-13 |
| 123 | Randomized Trial Evaluating The Rate of Pneumothorax in Severe Emphysema Secondary to Endoscopic Volume Reduction with Two-stage ZEPHYR® Valves Versus Endoscopic Volume Reduction with One-stage ZEPHYR® Valves PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) affects 3.5 million people and is the third leading cause of death worldwide. Emphysema involves air retention in the lungs and is ultimately responsible for a major deterioration in the quality of life. Available drug treatments have moderate efficacy whereas surgical lung volume reduction can improve exercise capacity when offered to a very selected population but at the cost of significant morbidity and mortality. Endoscopic Lung Volume reduction with ZEPHYR® valves improves respiratory function at rest, … |
UNIVERSITY HOSPITAL LIMOGES | 2024-05-06 |
| 124 | Oral Health Status of Cystic Fibrosis Patients. An Online Survey in Collaboration With The Vaincre La Mucoviscidose Patient Association PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cystic Fibrosis (CF) is a rare hereditary disease with autosomal recessive transmission, affecting 1 in 4700 births in France. Numerous studies have explored the links between oral health and CF, predominantly focusing on a children population. These studies reveal hyposalivation, a risk of dental erosion, an increased prevalence of enamel structural defects, but a reduced prevalence of dental caries in CF children, potentially explained by better oral hygiene. Periodontal disease does not appear to be increased in this population, while the oral quality of life of CF patients has been insufficiently studied. Today, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2024-05-01 |
| 125 | Effects of Cervical Nags on Accessory Muscles in Patients With Copd PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this work is to record changes on accessory muscles especially sternocleidomastoid and scalene after applying cervical NAGs in COPD patients. |
ASMAR FATIMA; | 2024-05-01 |
| 126 | The Effects of Acu-TENS in The Non-pharmacological Treatment of Dyspnea in Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnoea is one of the most important determinants of quality of life and often limits the activities of daily life, in subjects suffering from moderate-to-severe chronic obstructive pulmonary disease (COPD). Pharmachological treatment of dyspnoea is affected by several side effects and, in long-lasting treatments, a reduction of clinical efficacy may occur. Previous studies showed a reduction of perceived dyspnoea after trials of acupuncture or Transcutaneous Electrical Nerve Stimulation over acupoints (Acu-TENS). In this study will be investigated the effect of Acu-TENS on lung function and dyspnoea in patients with moderate-to-severe COPD (Cronic Obstructive Pulmonary Disease). |
ALESSANDRO TANI; | 2024-05-01 |
| 127 | Effect of CPAP on Respiratory Load and Lung Volume in Stable COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Both intrinsic positive end expiratory pressure (PEEPi) and dynamic hyperinflation are considered as inspiratory loads which increase work of breathing in patients with COPD. The application of extrinsic positive end expiratory pressure (PEEPe) supplied by CPAP has been claimed to reduce inspiratory load based on change in esophageal pressure which could be significantly affected by change in lung volume and airflow. The investigator hypothesized that CPAP could increase respiratory load because it increases lung volume. |
YUAN-MING LUO; | 2024-05-01 |
| 128 | A Controlled Breathing Intervention to Reduce Stress and Improve Symptoms in COPD Patients (REST): A Randomized Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a parallel design, randomized, controlled pilot trial comparing a controlled breath intervention (REST) to usual care for reducing stress in individuals with COPD. |
TRISHA M. PAREKH; | 2024-05-01 |
| 129 | Observational Retrospective Study To Describe Characteristics And Evaluate Real-World Outcomes in COPD Patients Initiating Trixeo Aerosphere (Budesonide/Glycopyrronium Bromide/Formoterol Fumarate) in Spain PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the ORESTES study is to describe the characteristics of the COPD patients initiating Trixeo (BGF -budesonide/glycopyrronium/formoterol) in Spain and to assess their real-world outcomes up to 12 months afterwards. For that purpose,a descriptive, observational, multi-centre, longitudinal, retrospective cohort study involving ~20 Spanish centres and aiming to include between 500 and 700 patients, has been designed. |
ASTRAZENECA | 2024-04-30 |
| 130 | A Non-interventional, Multi-centre Study to Investigate The Change in Patient-reported Outcomes in Moderate to Severe COPD Patients Newly Initiated on TRIXEO AEROSPHERE (Budesonide/Glycopyrronium/Formoterol) in Real-life Setting in Romania PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to describe patients’ clinical and self-reported outcomes of treatment with budesonide / glycopyrronium / formoterol Metered dose inhaler (BGF MDI) in Romania in real-life setting, up to 6 month of observation period. The study will focus primarily on the change in self-perceived health status in the first 12 weeks (3 months) of treatment with no pre-defined hypothesis. |
ASTRAZENECA | 2024-04-30 |
| 131 | A Phase I, Randomized, Partial Double-blind, Single-dose, 3-Way Cross-over Study to Assess The Total Systemic Exposure of Budesonide, Glycopyrronium, and Formoterol for BGF MDI HFO Compared With BGF MDI HFA Using An AeroChamber Plus Flow-Vu Spacer and to Compare The Total Systemic Exposure of BGF MDI HFO With A Spacer to BGF MDI HFO Without A Spacer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the effect on total systemic exposure and to characterize exposure BGF MDI HFO with a spacer compared to without a spacer; also, to demonstrate that total systemic exposure of BGF when administered as MDI HFO with a spacer is not greater than BGF MDI HFA with a spacer. |
ASTRAZENECA | 2024-04-26 |
| 132 | Pulmonary Thromboembolism in Patients Undergoing Percutaneous Pulmonary Thrombectomy: Need for Mechanical Respiratory And/or Circulatory Assistance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary embolism (PE) results from embolization of venous thrombi in the branches of the pulmonary arteries. Although anticoagulation is usually the preferred method of treatment, patients with high-risk and/or intermediate/high-risk pulmonary embolism may benefit from immediate reperfusion therapy, such as mechanical catheter thrombectomy. During this procedure, there may be an increase in pulmonary pressures caused by the introduction of pulmonary catheters, which may trigger hemodynamic instability. In addition, anesthesia performed during percutaneous mechanical thrombectomy may precipitate hemodynamic and respiratory compromise due to hypoxia, hypercapnia and increased airway pressure. We will perform a retrospective, … |
HOSPITAL UNIVERSITARI VALL D’HEBRON RESEARCH INSTITUTE | 2024-04-22 |
| 133 | Bronchodilator Effect of Oral Doxofylline and Procaterol in Chronic Obstructive Pulmonary Disease : A Randomized Crossover Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine if doxofylline and procaterol are effective in treating patients with stable chronic obstructive pulmonary disease (COPD). It will also assess the safety of both drugs. The main questions it aims to answer are: – Does doxofylline demonstrate a comparable bronchodilator effect to procaterol in COPD participants? – What medical problems do participants experience when taking doxofylline and procaterol? |
NARONGKORN SAIPHOKLANG; | 2024-04-16 |
| 134 | Accuracy of Accuhaler Tester, Ellipta Tester and Turbutester in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the accuracy of Accuhaler tester, Ellipta tester and Turbutester in patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is: • Do Accuhaler tester, Ellipta tester, and Turbutester demonstrate comparable accuracy to the In-check DIAL for assessing inspiratory inhalation force in COPD patients? |
NARONGKORN SAIPHOKLANG; | 2024-04-16 |
| 135 | Pivotal Study of The Performance and Safety of The Pneumoscope Device in Adults and Children PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Respiratory diseases are associated with high morbidity and mortality worldwide. Proper diagnosis and risk assessment of these conditions are essential for optimal management. Clinicians use three particularly useful tools to identify these conditions when assessing the patient’s status: the stethoscope, the pulse oximeter, and the thermometer. The Pneumoscope is an all-in-one device including a digital stethoscope, a pulse oximeter, and a thermometer. This study aims to assess the performance and safety of the Pneumoscope in recording respiratory sounds, body temperature, non-invasive blood oxygen saturation levels and heart rate in children and adults. |
JOHAN N SIEBERT; | 2024-04-15 |
| 136 | Influence of Airway Clearance Techniques on Ventilation Distribution in The Lateral Posture in COPD and Healthy Individuals PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: ELTGOL (Slow Expiration with the Opened Glottis in the Lateral posture) is an airway clearance technique performed in the lateral decubitus position. This technique focuses on optimizing ventilation of the infralateral lung (when the subject is lying in the lateral posture) to enhance local air-liquid interaction. Previous studies on ventilation differences between the infra- and supralateral lungs were conducted on healthy, young, male subjects, without the application of thoracic or abdominal pressure. This study aimed to assess ventilation distribution in right lateral recumbency in patients with chronic obstructive pulmonary disease (COPD), as well as healthy individuals, … |
WILLIAM PONCIN; | 2024-04-15 |
| 137 | Effect of PDE5 Inhibitor on Respiratory Symptoms in COPD Complicated By Pulmonary Hypertension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will study whether the drug tadalafil improves shortness of breath in 126 Veterans with Chronic Obstructive Pulmonary Disease (COPD) and high blood pressure in the lungs. The investigators will also assess whether tadalafil improves quality of life, home daily physical activity, exercise endurance, the frequency of acute flares of COPD, blood pressure in the lungs, … |
SHARON I ROUNDS; | 2024-04-01 |
| 138 | Validating The Accuracy of The Airvo 3 Device for Continuous Respiratory Rate Monitoring in Healthy Adults and Chronic Obstructive Pulmonary Disease (COPD) Patients: Comparison With A Reference Benchmark PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a clinical performance testing to validate the accuracy of the Airvo 3 device with respiratory rate algorithm manufactured by Fisher & Paykel Healthcare for continuous respiratory rate monitoring. |
MONICA RABANAL; | 2024-04-01 |
| 139 | Determination of The Effects of Walking and Home-Based Pulmonary Rehabilitation on Anxiety and Sleep Quality in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Although pulmonary rehabilitation plays an important role in increasing exercise tolerance and reducing hospitalizations in patients with chronic obstructive pulmonary disease (COPD), adherence to treatment is often low. Therefore, home-based pulmonary rehabilitation (PR) programs stand out as an effective intervention to alleviate the physiological and psychological burden of COPD patients and improve their quality of life. Nursing should develop a holistic approach to addressing the physical and psychological needs of patients to enhance the effectiveness of these programs. This study aims to evaluate the effects of an 8-week home-based PR program on cardiopulmonary parameters, respiratory function, anxiety levels, … |
BILECIK SEYH EDEBALI UNIVERSITESI | 2024-04-01 |
| 140 | A Randomized Controlled Study of The External Diaphragm Pacemaker Assisted Extubation in Premature Infants With Invasive Mechanical Ventilation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: With the development of perinatal medicine, more and more newborns with respiratory failure can be treated due to the use of respiratory support technology. However, long-term invasive mechanical ventilation treatment can lead to a series of complications such as ventilator-associated pneumonia, atelectasis and air leakage syndrome, … |
WANG JIANHUI; | 2024-03-31 |
| 141 | The Effect of Core Stabilization Training on Chest Expansion, Functional Capacity, and Trunk Muscle Endurance in Hearing-Impaired Children PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Children’s motor skills and physical performance increase with age due to the development of neuromuscular and cardiorespiratory systems. Sensory impairment seen in children with hearing loss can cause balance and coordination disorders, as well as decreased muscle strength and respiratory functions. Anatomically, core stabilization is provided by the diaphragm, abdominal, hip, pelvic floor, and gluteal muscles. Training for these muscles is intended to improve strength, endurance, and neuromuscular control. This training can help to improve the control of intra-abdominal pressure, intersegmental control of the spine, and muscular control of trunk movement. It also helps in strengthening the respiratory muscles, … |
DENIZ TUNCER; | 2024-03-30 |
| 142 | Pelvic Floor Exercises Versus Pilates on Urinary Incontinance in Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is To compare between the effect of both pelvic floor and Pilates exercises on urinary incontinences in COPD patients. |
RANA AYMAN; | 2024-03-29 |
| 143 | Effect of Motivational Interviewing Based on Pender’s Health Promotion Model on Patient-Reported Outcomes in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the effect of motivational interviewing based on Pender’s health promotion model on patient-reported outcomes in patients with COPD. |
ZEYNEP YILDIRIM; | 2024-03-29 |
| 144 | In Patients With Obstructive Airway Disease, Investigate The Effects of Different Breathing Strategies and Pedaling Rates on The Physiological Response to Bicycle Exercise PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The definition of obstructive airway disease is a ratio of the forced expiratory volume in one second (FEV1) to the forced vital capacity (FVC) of less than 0.7, which includes conditions such as chronic obstructive pulmonary disease, asthma, lymphangioleiomyomatosis, and bronchiolitis obliterans syndrome. For example, lung obstruction adversely affects many aspects of a patient’s health, such as lung function and exercise capacity. Pulmonary rehabilitation is widely used in patients with obstructive airway disease, and the prescription of pulmonary rehabilitation depends on exercise capacity parameters such as peak oxygen uptake (peak VO2), peak workload, and anaerobic threshold. However, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2024-03-20 |
| 145 | Alveolar-capillary Reserve After Exercise in COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass. |
RONAN BERG; | 2024-03-15 |
| 146 | Evaluation of The Multidimensional Impact of Therapeutic Education Workshops for COPD Patients, Cared for By The Maison De Prévention De La Santé Et D’Accompagnement Thérapeutique, in The North-West Val D’Oise Area PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess the impact of the Patient Therapeutic Education (PTE) workshops offered by the Maison de Prévention de la Santé et d’Accompagnement Thérapeutique (MPSAT) on the follow-up and feelings of the COPD patients who take part. These workshops are organised outside the hospital environment and supervised by hospital and town professionals in the NOVO zone. |
BRUNO PHILIPPE; | 2024-03-11 |
| 147 | Resistive Diaphragmatic Training Versus Volumes Oriented Spirometry On Pulmonary Function Test And Functional Capacity In Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Asthma, a chronic lung disease characterized by airway inflammation and constriction, presents ongoing challenges despite advancements in treatment. The aim of this study to deliver non-pharmacological interventions, particularly comparing resistive diaphragmatic training (RDT) and volume-oriented spirometry, to assess their efficacy in enhancing pulmonary function and functional capacity among asthmatic patients. it will compare resistive diaphragmatic training (RDT) with volume-oriented spirometry in asthmatic patients to pinpoint the superior method for enhancing lung function and daily capabilities. |
QURAT UL AIN; | 2024-03-10 |
| 148 | Effects of A Decision Support Intervention on End-of-life Care Planning in Chinese Older Adults With Advanced Disease and Their Family Members: A Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to test the effects of a patient decision aid (PDA) on planning for end-of-life (EOL) care among older adults with COPD. The main questions it aims to answer are: 1. Does a PDA improve the process of a person to make decisions on EOL care? 2. Does a PDA improve the readiness of a person to join advance care planning (ACP) communication? 3. Does a person make an advance directive after using a PDA? Participants in this study will: 1. Be randomly assigned to one of two groups. 2. In the experimental group, … |
LAI CHING TING; | 2024-03-10 |
| 149 | Combined Effects of Global Posture Re-education and Active Cycle of Breathing Technique on Cardiorespiratory Fitness, Posture and Quality of Life in Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The randomized controlled trial will involve 30 participants, with Group A receiving GPRM and ACBT, while Group B follows the conventional COPD model that includes ACBT only.Assessments of heart rate, physical fitness, and quality of life will contribute to a nuanced understanding of joint function, informing future COPD treatment paradigms. |
MUHAMMAD FAIZAN HAMID; | 2024-03-03 |
| 150 | Combined Effects of Lion’s Breath Technique With Chest Percussion Therapy in Pneumonia Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be randomized controlled trial with non-probability convenient sampling. Sample size will be 90,45 in each group. Outcome will be measured by using 6 minute walk test, Spirometry (FVC, FEV1/FVC and PEF), Functional Independence Measure. |
MUHAMMAD FAIZAN HAMID; | 2024-03-01 |
| 151 | Effect of PEP Buddy During Aerobic Training on Breathing, Exercise, and Sleep Quality in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Exercise intolerance and sleeping problems are among the most common symptoms experienced by patients with chronic obstructive pulmonary disease (COPD), which is associated with lung dynamic hyperinflation (DH). There was evidence that positive expiratory pressure (PEP), which less costly devices could offer, could reduce DH. A positive expiratory pressure device improved COPD-related symptoms in more than 70% of patients with COPD. PEP buddy is an adjunct to current COPD therapies, such as inhalers and pulmonary rehabilitation. It provides a tool for self-management and breathing re-training, reducing dyspnea and improving quality of life. |
EBTESAM NABIL; | 2024-03-01 |
| 152 | Interpreting Respiratory Oscillometry in Adult Asthma and COPD: A Delphi Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an international Delphi study to consolidate expert consensus on the use of respiratory oscillometry in the management of adult patients with asthma or chronic obstructive pulmonary disease (COPD). The primary objective of the Delphi study is to aid the interpretation of respiratory oscillometry in clinical practice amongst adult patients with asthma or COPD. This will be achieved by obtaining expert consensus on: – Which parameters are used in clinical practice for impulse oscillometry (IOS) and for forced oscillation technique (FOT) devices. – … |
LI PING CHUNG; | 2024-03-01 |
| 153 | Efficacy and Safety of Chinese Herb Medicine-Moxibustion Therapy on Chemotherapy-Induced Leukopenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cancer is the second leading cause of death globally, with an estimated 9.6 million deaths in 2018, accounting for one-sixth of total deaths. The economic burden of cancer continues to rise globally, causing significant physiological, psychological, and economic pressures on individuals, families, communities, and healthcare systems. The toxic effects of chemotherapy, such as nausea, vomiting, decreased blood cells, fatigue, etc., can impair patients’ function, activities, and quality of life. Chemotherapy-induced leukopenia (CIL), particularly low white blood cell counts (48.9%), … |
CHENG MING HUEI; | 2024-03-01 |
| 154 | An Observational, Non-Interventional Comparative Effectiveness Study of Mortality Outcomes and Related Cardiopulmonary Events Among A Cohort of Commercially Insured Chronic Obstructive Pulmonary Disease (COPD) Patients Who Initiate Breztri and Multiple Inhaler Triple Therapy (MITT) in The United States (US) PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with chronic obstructive pulmonary disease (COPD) have elevated risk of mortality and cardiopulmonary events, particularly following exacerbations. While single inhaler triple therapies (SITTs), such as budesonide/glycopyrrolate/formoterol fumarate (BGF), reduce mortality and cardiopulmonary event risk versus dual bronchodilator therapy, … |
ASTRAZENECA | 2024-02-29 |
| 155 | Combined Effects of Ba-Duan-Jin Based Deep Breathing Exercises and Forced Expiratory Technique in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be a randomized control trial. A total of 68 patients will be recruited and randomly assign to the experimental group or the control group in a 1:1 ratio. Participants in the experimental group will receive a 8-week Ba-duan jin exercise training intervention along with Forced Expiratory Technique at least 3 days a week and 30 minutes a day, while participants in the control group will be only given Forced Expiratory intervention and will be told to maintain their original lifestyle for 8 weeks along with standard COPD treatment. |
MUHAMMAD FAIZAN HAMID; | 2024-02-29 |
| 156 | The Detection of Chronic Obstructive Pulmonary Disease in Patients With Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Chronic obstructive pulmonary disease (COPD) is an ongoing lung condition caused by damage to the lungs. The damage results in swelling and irritation, also called inflammation, inside the airways that limit airflow into and out of the lungs. Diabetes can worsen the progression and prognosis of COPD. |
MUHAMMAD NAVEED BABUR; | 2024-02-28 |
| 157 | Investigation of Vestibular System Influence in Individuals With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: . The main question is whether the vestibular system is affected by COPD. If there is an influence, the second question is what is the relationship between balance and vestibular interaction in COPD patients. A total of 10 COPD patients and 10 healthy adults will include the study. Respiratory functions, … |
NIMET SERMENLI AYDIN; | 2024-02-25 |
| 158 | A Randomized, Double-blind, Parallel Group, Multi-center, Phase III Study to Assess The Efficacy of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler Relative to Glycopyrronium and Formoterol Fumarate MDI on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease (THARROS) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk. |
ASTRAZENECA | 2024-02-21 |
| 159 | Inclusion of Calcifediol in The Hospital Therapeutic Protocol for Treatment of SARS-CoV-2 Disease (COVID-19). Mortality Analysis. Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome variables, such as admission to the Intensive Care Unit (ICU), to Gerencia de Atención Integrada (GAI) de Albacete. Complejo Hospitalario Universitario de Albacete. Albacete (Spain), based on the files of the MXXI medical records, Information System of the Laboratory (ISL) and Pharmacy. |
COMPLEJO HOSPITALARIO UNIVERSITARIO DE ALBACETE | 2024-02-21 |
| 160 | Impact of Chronic Obstructive Pulmonary Disease (COPD) on Sexual Health, Loneliness, and Well-being: A Cross-sectional Study of Prevalence and Associated Variables in Individuals With and Without COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Summary Person-centered care is a hot topic within healthcare, yet communication about patients’ sexual health and intimacy issues remain too hot to handle within healthcare. Research indicates that sexual dysfunction and impaired sexual health are frequent among individuals with chronic obstructive pulmonary disease (COPD). Despite patients expecting healthcare professionals to address intimacy issues; these issues are often neglected, since the topic is a taboo. This study aims to address a gap in observational research by investigating the physical, … |
ANDERS L. OTTESEN; | 2024-02-20 |
| 161 | Effect of Chest Mobility Exercises Versus Proprioceptive Neuromuscular Facilitation in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chest mobility exercise versus proprioceptive neuromuscular facilitation in patients with chronic obstructive pulmonary disease |
ISAAC ZAKARIA ZARII YANII; | 2024-02-17 |
| 162 | The Effect of Airway Oscillation and Chest Wall Oscillation on Respiratory Functions and Sleep Quality in COPD Patients in Acute Exacerbation Period and Technical Inspection of Devices PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD); It is a common, treatable and preventable disease characterized by progressive and irreversible airflow limitation and has systemic effects with respiratory system involvement. Increased respiratory workload, decreased work . |
GAMZE ALTINKAYNAK; | 2024-02-15 |
| 163 | Effects of Active Cycle of Breathing Techniques With and Without Acapella in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease refers to a group of progressive lung diseases the block air flow and make it difficult to breath. It is potentially fatal and fourth leading cause of death in the world. The symptoms of this condition include shortness of breath, frequent coughing, … |
MADIHA YOUNIS; | 2024-02-15 |
| 164 | The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Major progress has been made in the area of cardiovascular disease, but we believe that further progress will involve mechanistically addressing underlying respiratory causes including chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA). The most common cause of death in COPD is cardiovascular, although mechanisms are unknown. OSA has been associated with major neurocognitive and cardiovascular sequelae, the latter likely a function of autonomic nervous system abnormalities, oxidative stress, inflammation, and other pathways. Recent data suggest that individuals with OVS die preferentially of cardiovascular disease compared to OSA or COPD alone, … |
ATUL MALHOTRA; | 2024-02-13 |
| 165 | Hypoxemia in The First 24 Hours After Trauma – An Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the occurrence of hypoxemia (an abnormally low concentration of oxygen in the blood) in trauma patients within the first 24 hours of hospital admission following arrival to a trauma center. The main questions the study aims to answer are: – Do trauma patients experience hypoxemia during the initial 24 hours of hospital admission following trauma? – … |
JACOB STEINMETZ; | 2024-02-13 |
| 166 | Effect of Hawthorn Vinegar, Black Mulberry Syrup and Green Tea on Quality of Life Related to Oral Mucositis and Oral Health in Individuals With Diabetes: Single Blind Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this context, this study investigated the quality of life related to oral mucositis and oral health in patients with DM using hawthorn vinegar, black mulberry syrup and green tea. |
HATICE DEMIRAĞ; | 2024-02-06 |
| 167 | Cross-Talk Between Arterial Calcifications PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Potential Cross-Talk Between Arterial Calcifications Background Vascular calcification is a key component of atherosclerosis. This study investigates the potential correlations between aortic and coronary calcifications detected via abdominal CT, considering age-related variations, to explore the possibility of cross-talk. Method A total of 921 patients (n=921) \[male: 508 (55%), female: 413 (44.7%)\] were divided into three age groups: 40-49, 50-69, and 70-90 years. Non-contrast abdominal CT scans were evaluated for calcifications in the coronary arteries, thoracic aorta, abdominal aorta (AA(1): suprarenal, AA(2): renal, AA(3): infrarenal), iliac arteries, and femoral artery. Aortic branches were categorized by calcification levels: none, \<25%, 25-50%, ≥50% |
ŞAHBENDER KOÇ; | 2024-02-02 |
| 168 | Efficacy of Phosphodiesterase Type 5 Inhibitors in Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ERASE PH-COPD is a randomized double-blind study, with 2 parallel groups. Patients with severe pulmonary hypertension due to chronic obstructive pulmonary disease, will be randomly assigned to receive Tadalafil orally or placebo. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2024-02-01 |
| 169 | Validation of A Digital Platform for Functional Respiratory Rehabilitation (ReHub) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD), characterized by persistent airflow limitation in the respiratory airways, is a chronic condition that affects millions of people worldwide. ReHub enables healthcare professionals to design therapeutic exercise programs for the treatment of COPD patients, … |
CARME PUY; | 2024-02-01 |
| 170 | Cross Cultural Validation of Urdu Version of Leicester Cough Questionnaire (LCQ) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Leicester Cough Questionnaire (LCQ) is a patient reported, 19-item tool, and it comprised physical, psychological, and social elements. The objective of the study is to cross culturally adapt LCQ in Urdu language and to find the reliability and validity in patients of COPD. It is a three-stage study. Leicester Cough Questionnaire (LCQ) will be adapted in Urdu and will be first tested for its content validity by using content validity index (CVI). In the second stage, the Urdu version of the Leicester Cough Questionnaire (LCQ) will be pilot run; tested for its validity and reliability. In the third stage, … |
WAJEEHA ZIA; | 2024-02-01 |
| 171 | Study of Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease (COPD). Effect of Body Composition PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnea, more commonly known as breathlessness, is a symptom found in the majority of patients with chronic obstructive pulmonary disease (COPD), with a major impact on quality of life and mortality. COPD is a chronic inflammatory disease of the bronchi, affecting 8% of the French population (more than 3 million people). By 2030, it will be the third leading cause of death worldwide. Effective management of dyspnea in these patients is a priority. In patients with severe COPD, physical exertion increases the workload of breathing, leading to dyspnea. At the same time, the respiratory muscles and fatty cells release cytokines, … |
CAMILLE ROLLAND-DEBORD; | 2024-02-01 |
| 172 | Impact of Support Groups for Patients With Non-Cystic Fibrosis Bronchiectasis on Quality of Life and Exacerbations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: BronchConnect is a prospective trial to investigate the impact of support groups on health care related quality of life in those with noncystic fibrosis bronchiectasis (NCFBE). It has been well demonstrated that participation in patient support groups improves quality of life in those who suffer from interstitial lung disease and chronic obstructive pulmonary disease, but the impact is largely unknown for those who live with NCFBE, a chronic lung disease with rising prevalence with no targeted FDA-approved therapy. NCFBE causes chronic cough, dyspnea, recurrent infections, … |
SHOSHANA ZHA; | 2024-02-01 |
| 173 | Xenon Xe 129 Hyperpolarized MRI Ventilation Imaging for The Evaluation of Treatment Response Comparing Three Different Bronchodilator Aerosol Delivery Methods in Patients With COPD: A Pilot Study Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare responses to bronchodilator treatment delivered by three different aerosol delivery methods in patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is whether there are differences in lung ventilation following treatment with each of the three methods as measured using hyperpolarized Xe 129 with MRI. Participants will: Receive a standard dose of albuterol delivered using each of 3 aerosol delivery devices. In total, participants will receive three treatments separated by at least 1 week each. Following each treatment, … |
JAIME MATA; | 2024-02-01 |
| 174 | A Portable Dyspnea Relief Device for Episodic Breathlessness in COPD (PEP-buddy): Effect on Dyspnea Severity and Mechanism of Action PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic dyspnea is the most characteristic symptom of patients with Chronic Obstructive Pulmonary Disease (COPD), with intermittent increases during exercise and other events.Despite optimal standard therapy, episodic dyspnea is a common occurrence in COPD. Recently, the PEP buddy was developed which is an easy-to use, hands-free device that generates positive expiratory pressure (PEP). Although currently the available evidence is limited, it indicates that utilizing the PEP-buddy can result in enhancements in dyspnea during exertion, exertional desaturation and overall quality of life. More research is needed to evaluate the effectiveness of this device and the long term usability, … |
JE HARTMAN; | 2024-01-31 |
| 175 | Feasibility of Semaglutide Therapy for Weight Loss in Advanced Lung Disease: A Pilot Study Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide therapy? 2. Are we able to titrate semaglutide therapy to a target weight? Participants will be asked to perform pulmonary function, physical function and body composition testing, as well as a blood draw before and after 12-weeks of semaglutide therapy. While on therapy, … |
MICHAELA R ANDERSON; | 2024-01-29 |
| 176 | Prediction Model for Postoperative Pulmonary Complications in Patients Undergoing Lung Transplantation Using Machine Learning: A Retrospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Since the first human lung transplantation in 1963, significant advancements in immunosuppressive agents from the mid-1990s have greatly improved the quantity and quality of such procedures. In 2004, a total of 1,815 lung transplantations were globally reported. Patients undergoing this procedure are typically elderly and experience not only impaired lung function but also overall health instability. Despite successful outcomes, postoperative pulmonary complications (PPCs) can lead to serious consequences, including deterioration and fatality. PPCs resulting from lung transplantation may lead to prolonged hospitalization, increased complications, and the need for additional treatment. Various factors, such as age, smoking, pre-existing lung diseases, … |
KIM HEE YOUNG; | 2024-01-22 |
| 177 | Associates Of, and Time to Recovery From, Eosinopenia in Severe COPD Exacerbation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goals of this observational study are to identify factors independently associated with admission eosinopenia in patients with a severe exacerbation of chronic obstructive pulmonary disease (COPD) and to determine when blood eosinophil count (BEC) will recover to baseline stable state in patients who are admitted to hospital with a severe exacerbation of COPD and associated eosinopenia. The main aims of the study are to: 1. Identify demographic, … |
PETER IRELAND; | 2024-01-22 |
| 178 | Association Between Handgrip Strength and Small Airway Disease in Patients With Stable Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the correlation between handgrip strength and small airway disease among patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is: • Is handgrip strength correlated with small airway disease in COPD patients? Participants will perform handgrip strength test and impulse oscillometry (IOS). |
NARONGKORN SAIPHOKLANG; | 2024-01-22 |
| 179 | Mechanical Properties of Peripheral and Accessory Respiratory Muscles in Chronic Obstructive Pulmonary Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The biomechanical properties of accessory respiratory muscles and peripheral muscles of COPD and healthy subjects will be measured and compared with the MyotonPro device. |
ESRA PEHLIVAN; | 2024-01-20 |
| 180 | Correlation Between Handgrip Strength and Air Trapping in Patients With Stable Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the relationship between handgrip strength and air trapping in patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is: • Is handgrip strength correlated with air trapping in COPD patients? Participants will perform handgrip strength test and lung volume measurement. |
NARONGKORN SAIPHOKLANG; | 2024-01-20 |
| 181 | Examining The Relationship Between Respiratory Muscle Fatigue and Lower Extremity Muscle Oxygenation in Chronic Obstructive Pulmonary Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In our study, changes in vastus lateralis muscle oxygenation will be evaluated with the Moxy device, a functional infrared oxygen measurement device, during the inspiratory muscle fatigue protocol in COPD cases and the healthy control group. |
ESRA PEHLIVAN; | 2024-01-20 |
| 182 | Combined Effects Of Autogenic Drainage and Segmental Breathing Techniques in Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease is one of the most common life threatening disease affecting population. It is a preventable and treatable lung disease. People with COPD must work harder to breathe, which can lead to shortness of breath and/or feeling tired. Autogenic drainage (AD) works by adapting your breathing and maximizing airflow within the airways to improve ventilation and clear sputum. Segmental breathing, also referred to as localized expansion breathing, … |
SIDRA AFZAL; | 2024-01-15 |
| 183 | Comparative Effects of Chest Physiotherapy and Lungs Squeezing Technique in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic pulmonary obstructive disease refers to a group of lungs problems that includes blockage of airway and difficulty in breathing. It includes mostly emphysema, asthma and chronic bronchitis. Chronic pulmonary obstructive disease is the third main cause of death in the whole world .The diagnosis of chronic obstructive pulmonary disease can be made by spirometer and the ratio of forced expiratory volume in 1 second over forced vital capacity (FEV1/FVC) should be less than 70%. It shows severity of airway obstruction .First technique is Chest physiotherapy, … |
SIDRA AFZAL; | 2024-01-15 |
| 184 | Task-specific Training for Patients With Acute Exacerbation of COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with Chronic Obstructive Pulmonary Disease (COPD) experience a progressive deterioration in their quality of life. Task-specific training is a type of approach focused on chronic patients that allows the acquisition of new skills or improvement of lost skills. The overall objective of this project is to evaluate the effectiveness of a task-specific training program during hospitalization of patients with acute exacerbation of COPD. A randomized clinical trial will be conducted in patients hospitalized for COPD. Participants after signing informed consent will be randomized between the control group (standard treatment) and the intervention group (task-specific training program in addition to standard treatment). The task-specific training program is a multidisciplinary program divided into three blocks where specific tasks will be performed on symptom education, education of activities of daily living and improvement of physical capacity with the aim of reinforcing skills necessary for the self-management of COPD patients in the short, medium and long term. |
MARIE CARMEN VALENZA; | 2024-01-15 |
| 185 | Combined Effects of Blow Bottle Device and Postural Drainage in Moderate to Severe Elderly COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It will be a randomized clinical trial. Age of selected subjects will be between 40 to 70 years. Data will be collected from Wazirabad institute of cardiology. There will be 2 groups i.e. group A will receive combination of blow bottle technique and postural drainage and group B will receive postural drainage. Spirometer will be used to evaluate pulmonary functions and breathless, cough and sputum scale (BCSS) will be used to evaluate the improvement in sputum diary of patients. Interventions will be given to the patients for 20-25 minutes twice a day for 6 days per week. After data collection, … |
SIDRA FAISAL; | 2024-01-15 |
| 186 | Combined Effects Of of Pursed Lip Breathing and Coordinated Breathing During Aerobic Exercise on Aerobic Capacity, Dyspnea and Anxiety Level in Adult Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: COPD is the chronic lung condition characterized by the damage and enlargement of the air sacs in the lungs, leading to breathing difficulties. A blockage may develop, which traps air inside your lungs. The patient shows clinical manifestation of cough, wheezing, chest tightness, … |
SIDRA AFZAL; | 2024-01-15 |
| 187 | Impact Du Bilan Et De La Prise En Charge Des Comorbidités En Médecine Interne Sur Le Risque Cardiovasculaire PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of assessing and managing cardiovascular risk is to avoid, limit or delay cardiovascular morbidity and mortality. Planned internal medicine hospitalization is developed around the management of cardiovascular risk in patients at high cardiovascular risk, whether in primary prevention or secondary prevention. During planned hospitalization, patients benefit from comprehensive, personalized and adapted care for their comorbidities and their CVRF (cardiovascular risk factors). This study will make it possible to evaluate this overall course of multidisciplinary management of comorbidities of patients at high cardiovascular risk. |
CAMILLE ROUBILLE; | 2024-01-15 |
| 188 | A Double-blinded Extension Study to Evaluate The Long-term Safety and Tolerability of Itepekimab in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Participated in Either EFC16750 or EFC16819 Clinical Studies PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a parallel, double blind, Phase 3, 2-arm study that is designed to provide additional safety information, assess the durability of treatment response, and provide additional PK and immunogenicity assessments. The primary purpose of this study is to evaluate safety and tolerability of both itepekimab SC Q2W or itepekimab SC Q4W in participants with COPD having completed the treatment period of the clinical studies EFC16750 or EFC16819. A secondary purpose of this study is to provide efficacy outcomes beyond the treatment period of the parent trials EFC16750 and EFC16819. Study details include: * The study duration will be up to 72 weeks * The treatment duration will be up to 52 weeks * A follow-up period of 20 weeks will be conducted * The number of on-site visits will be 7 and the number of phone contacts will be 5 |
SANOFI | 2024-01-11 |
| 189 | A Randomised, Placebo-Controlled, Double-Blind, Multi-Centre, 4-week, 3-way Crossover Pharmacodynamic Study to Assess The Equivalence of Budesonide, Glycopyrronium, and Formoterol Fumarate (BGF) Delivered By MDI HFO Compared With BGF Delivered By MDI HFA in Participants With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to demonstrate that the lung function effect from orally inhaled BGF delivered via HFO propellant is equivalent to the lung function effect from orally inhaled BGF delivered via HFA propellant in participants with COPD. The study duration for each participant will be approximately 15 to 16 weeks and consist of: 1. A screening and placebo run-in period of approximately 2 weeks prior to first dosing 2. Three treatment periods of approximately 4 weeks each (one period for each of 3 study interventions) 3. A final safety follow-up visit via telephone contact approximately 1 to 2 weeks after the final dose administration Participants will be provided with rescue SABA (albuterol or salbutamol) to be used as needed throughout the study. Participants will attend in-clinic study visits approximately weekly during the screening/run-in period (Visits 1, 2, and 3), then every 4 weeks (Visits 4, 5, and 6) to receive take-home study treatment, measure their lung function, and assess their health and safety |
ASTRAZENECA | 2024-01-11 |
| 190 | Evaluation of The Effect of Music Therapy on Dyspnea Severity and Vital Signs In Intensive Care Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the effect of music therapy on dyspnea severity and quality of life indicators in patients with Chronic Obstructive Pulmonary Disease (COPD) admitted to the intensive care unit. The study will be conducted at Isparta City Hospital and Kumluca State Hospital in Antalya, Turkey, using an experimental design. Patients will be divided into experimental and control groups, selected using randomization. Patients in the experimental group will receive music therapy in the Hüseyni maqam, … |
HAFIZE AYDEMIR; | 2024-01-07 |
| 191 | The Effect of A Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans With COPD and Chronic Musculoskeletal Pain PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Persons with COPD benefit from being physically active, but they are often limited by chronic musculoskeletal pain. This project will determine whether a non-pharmacologic, integrated, technology-mediated walking and Tai Chi mindfulness intervention can improve physical function in Veterans with COPD and chronic musculoskeletal pain. The proposed research addresses VA Rehabilitation R\&D Service’s high priority area of improving health-related quality of life by reducing disease burden and maximizing function in Veterans with chronic disease. |
MARILYN L. MOY; | 2024-01-03 |
| 192 | Determination of The Effects of Two Different Breathing Techniques and Forward-Leaning Position on Physiological Parameters in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine the effects of balloon inflation and pursed-lip breathing exercises, in addition to the forward-leaning position, on physiological parameters in individuals with Chronic Obstructive Pulmonary Disease (COPD). The hypotheses of the study are as follows: H1_1: The forward-leaning position and balloon inflation breathing exercise have a positive effect on physiological parameters in patients with Chronic Obstructive Pulmonary Disease (COPD). H1_2: The forward-leaning position and pursed-lip breathing exercise have a positive effect on physiological parameters in patients with COPD. H1_3: There is a significant difference in physiological parameters between the balloon inflation and pursed-lip breathing exercise groups and the control group. Within this scope, the study will be conducted with three groups: Intervention Group 1: Balloon inflation exercise applied in addition to the forward-leaning position. Intervention Group 2: Pursed-lip breathing exercise applied in addition to the forward-leaning position. Control Group: Standard practice implemented in the institution where the study is conducted. Participants: * A home exercise program will be designed for both intervention groups, allowing them to perform the exercises independently each day. * The exercises will start with three sessions per day and will be increased by one session each week, continuing for a total of four weeks. * Participants will visit the outpatient clinic in the 4th week for assessments and tests. * Patients will be contacted weekly by the researcher via phone to ensure adherence to the program. |
SEMRA ACIKSOZ; | 2024-01-03 |
| 193 | Respiratory Rehabilitation and The Impact of Psychiatric Comorbidities PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with respiratory insufficiency, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, asthma, bronchiectasis, and, to a lesser extent, other pathologies that result in respiratory insufficiency and require rehabilitation are admitted to in-hospital Respiratory Rehabilitation. Several studies have assessed the impact of comorbidities in the most frequent respiratory diseases such as COPD, asthma, pulmonary fibrosis, and cystic fibrosis in terms of worsening mortality, morbidity, and disease progression. However, to our knowledge, … |
MICHELE VITACCA; | 2024-01-02 |
| 194 | Effect of Time of Exercise Re-training on Functional Capacity in Individuals With Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies. The program should not be improved by introducing new subjects such as circadian rhythm. |
MICHAËL RACODON; | 2024-01-02 |
| 195 | A Multicenter, Non-interventional, Observational Clinical Trial to Assess The Quality of Life in Patients With ChRonic ObstructIve Pulmonary Disease Who Require Tiotropium As AdditiOnal TreatmeNt PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous disease usually with a decline lung function and worsening symptoms; hence, both forced expiratory volume in 1 s (FEV1; lung function) and validated patient-reported outcomes (PROs) are used in clinical trials to assess disease severity and response to treatment. The PROs are different in terms of their scope of assessment and in the information that they capture. PRO questionnaires such as the Baseline Dyspnoea Index (BDI), Transition Dyspnoea Index (TDI) and modified Medical Research Council (mMRC) dyspnoea scale are used to assess dyspnoea, whereas the Clinical COPD Questionnaire (CCQ), … |
ELPEN PHARMACEUTICAL | 2024-01-01 |
| 196 | The Effect of Patient Empowerment Training on Patients’ Self-Efficacy, Health Locus of Control and Perception of Nursing Care Quality PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study, planned in a randomized, pre-test, post-test, control group and single-blind research design, is to examine the effect of empowerment training given to inpatients diagnosed with chronic obstructive pulmonary disease (COPD) on the patients’ self-efficacy, … |
FILIZ OZBEY; | 2024-01-01 |
| 197 | Comparison of Viscoelastic Properties of Respiratory Muscles and Peripheral Muscles in Chronic Obstructive Pulmonary Disease Patients With Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to compare the viscoelastic properties of auxiliary respiratory muscles and peripheral muscles of chronic obstructive pulmonary disease patients with healthy subjects. Myotonometry was used to evaluate the viscoelastic properties of the muscles. The viscoelastic properties of the sternoclaidus mastoid, pectoralis major, upper trapezius, deltoid, biceps brachii, rectus femoris, gastrocinemius, and tibialis anterior muscles were evaluated. |
ÇAĞTAY MADEN; | 2024-01-01 |
| 198 | Evaluation of Consumption of Sevoflurane in Chronic Obstructive Pulmonary Disease Patients Under General Anesthesia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: All the Patients undergoing General Anesthesia and the patients who are having Chronic Obstructive Pulmonary Disease will be considered for this study. The Volume consumption of Sevoflurane will be studied in accordance with age, sex, duration , type of surgery, site of surgery and BMI.The volume consumption of sevoflurane is compared with Chronic Obstructive Pulmonary Disease and Normal Patients . |
SANTHOSH KUMAR T N; | 2024-01-01 |
| 199 | Heat Waves and The Elderly With COPD: Reducing Thermal and Cardiovascular Consequences PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate thermoregulatory responses in older individuals with COPD. |
CRAIG CRANDALL; | 2024-01-01 |
| 200 | Effects of Smart Eccentric Exercise Training on Lymphocyte Immunity and Erythrocyte Rheology in Patients With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to design eccentric exercise strategies for COPD patients to comprehensively improve their cardiopulmonary/muscular fitness, immune and hemorheological functions, and quality of life, thereby improving the prognosis of their disease. |
KE-YUN CHAO; | 2023-12-30 |
| 201 | Open-label Single-arm, Non-interventional, Multi-centre, Cohort Study for Evaluation of Clinical and Patient Reported Outcomes in New Users of BREZTRI (Budesonide / Glycopyrronium / Formoterol) in Routine Care Settings Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective-prospective, non-interventional, multi-centre study that will be conducted in routine clinical settings in Russia. Eligible patients with moderate to severe COPD routinely treated with BREZTRI will be observed according to routine clinical practice for up to 24 weeks. |
ASTRAZENECA | 2023-12-29 |
| 202 | Effect of Inspiratory Muscle Training Versus Transcutaneous Electrical Diaphragmatic Stimulation on The Severity of Copd PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a common and treatable disease characterized by progressive airflow limitation and tissue destruction. It is associated with structural lung changes due to chronic inflammation from prolonged exposure to noxious particles or gases most commonly cigarette smoke. POWERbreathe device (POWER-breathe International Ltd., Southam, Warwickshire, UK) is an inspiratory muscle training and this device has recently shown benefits on pulmonary function. Also, … |
ALAA MOHAMED EL-MOATASEM MOHAMED; | 2023-12-12 |
| 203 | Prehospital Use of Non-invasive Ventilation for Acute Respiratory Failure Due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test if treatment with prehospital Non-invasive ventilation (NIV) for patients with acute respiratory failure (ARF), due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) based on in-hospital criteria, … |
JESPER H HAUNSTRUP BRENDEL; | 2023-12-08 |
| 204 | Pulmonary Ventilation Heterogeneity Determined By Electrical Impedance Tomography During Pulmonary Function Testing in Subjects With Normal One-second Rates PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the demographic characteristics of normal one-second rates population in patients with pulmonary function tests recommended by outpatient physicians. To investigate whether EIT can identify spatial and temporal heterogeneity of lung ventilation in individuals with normal one-second rates during pulmonary function testing. To investigate the distribution patterns of lung ventilation in individuals with normal one-second rates using this technique, and provide references and evidence for early screening, diagnosis, treatment monitoring, and prognostic evaluation. |
SIR RUN RUN SHAW HOSPITAL | 2023-12-05 |
| 205 | The Effect of Training Given to Patients With COPD in Line With Pender’s Health Promotion Model on Self-Efficacy Level PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was conducted as a randomized controlled experimental study. The study was conducted with patients hospitalized in the chest diseases intensive care unit of a state hospital. The study was terminated with the participation of 140 patients, 70 in each group. Data were collected with Descriptive Information Form and COPD Self-Efficacy Scale. |
SEVDA KORKUT; | 2023-12-01 |
| 206 | A Phase 2a Randomized, Doubled-Blind, Placebo-Controlled Trial to Evaluate Safety, Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: AECOPD is a major cause of hospital admission and mortality. They contribute to long-term decline in lung function, physical capacity, and quality of life (QoL). RLS-0071 is a novel peptide being developed for the treatment of AECOPD. This study is designed to evaluate the safety and tolerability of RLS-0071 in the treatment of adults with moderate exacerbations of COPD. |
REALTA LIFE SCIENCES | 2023-12-01 |
| 207 | High Flow Nasal Oxygen For Hypercapnic, Acidotic Exacerbation Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this pilot study the feasibility of performing a larger trial to study the non-inferiority of High Flow Nasal Oxygen compared to non-invasive ventilation in patients with acute acidotic hypercapnic exacerbation of COPD wil be investigated |
DORIEN KIERS; | 2023-12-01 |
| 208 | Femoral Artery Blood Flow During Rest and One-leg Knee Extensor Exercise in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Doppler ultrasound is generally considered to provide reliable femoral blood flow measurements between rest and exercise, and the blood flow response to exercise is widely believed to be reduced in patients with chronic obstructive pulmonary disease (COPD). However, the test-retest reliability of the method during one-leg knee extensor exercise has not previously been compared between matched healthy individuals. |
MILAN MOHAMMAD; | 2023-12-01 |
| 209 | Randomised Control Trial to Study The Role of Non-invasive Ventilation Using Pressure Support Ventilation Versus Adaptive Support Ventilation With Intellisync Mode in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute exacerbation of COPD is defined acute worsening of respiratory symptoms requiring additional therapy. COPD exacerbations affects the health status and quality of life of affected patients. The inpatient mortality during exacerbation is 3 to 4% while, … |
INDERPAUL SINGH; | 2023-12-01 |
| 210 | A Pilot, Observation and Feasibility Study of Prevora (DIN 02046245) Integrated Into Homecare Visits of Adults With COPD or CHF or on Dialysis or Other Chronic Metabolic Conditions Which Are Correlated With Chronic Oral Inflammation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prevora is an antiseptic medication and dental treatment approved by Health Canada for reducing root decay (cavities) in adults at high risk of dental decay. An antiseptic kills germs and harmful bacteria. Prevora is applied to the teeth and gumline by a medical professional, takes about 10 minutes and is painless. Participating site(s) have a homecare program and usual care includes offering patients home care services before discharge from the hospital for some chronic diseases. Usual care includes home visits by a nurse and or personal support worker (PSW). The aim of this study is to explore the effectiveness, … |
CARRIE BELTZNER; | 2023-12-01 |
| 211 | Comparison of The Effects of Yoga and Conventional Physiotherapy Programs on Fatigue, Pulmonary Functions and Exercise Capacity in Patients With Sarcoidosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sarcoidosis is a multisystem disease, characterized by the formation of immune granulomas with various clinical symptoms depending on the involved organs, which can involve many organs and systems associated with emotional and physical consequences that affect the quality of life, whose cause is unknown, but usually affects the respiratory system, and occurs mostly in young and middle-aged adults. Lung involvement, seen in 95% of patients, causes limitation of lung capacity and decrease in inspiratory muscle strength, which are important factors that lead to an increase in dyspnea and a decrease in walking distance. In addition to respiratory muscle weakness, … |
ŞEYDA YILDIZ; | 2023-11-30 |
| 212 | Vowel Segmentation for Classification of Chronic Obstructive Pulmonary Disease Using Machine Learning PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This work aims to evaluate whether the segmentation of vowel recordings collected from patients diagnosed with COPD and healthy control groups can increase the classification precision of machine learning techniques. |
JOHAN SANMARTIN BERGLUND; | 2023-11-28 |
| 213 | A Two-part Phase 1 Randomized, Double-blind, Placebo-controlled Study to Investigate Safety, Tolerability, Immunogenicity, Pharmacokinetics and Pharmacodynamics of GSK3862995B Following Single Ascending Doses in Healthy Participants and Repeat Doses in Participants With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to investigate the safety and tolerability of ascending doses of GSK3862995B following single dose in healthy participants and repeat doses in participants with Chronic obstructive pulmonary disease (COPD). |
MICHAEL DENENBERG; | 2023-11-27 |
| 214 | Effects of Pilate Versus Aerobic Exercises on Dyspnea , Functional Capacity and Anxiety Status in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare the effects of Pilates, with its emphasis on proper breathing and muscle activation, and aerobic exercises, known for improving cardiovascular fitness, on dyspnea, anxiety, and functional capacity in COPD patients. |
TASNEEM SHEHZADI; | 2023-11-23 |
| 215 | A Trial in Participants With Chronic Obstructive Pulmonary Disease (COPD) to Evaluate The Impact of Vapendavir on The Development of Lower Respiratory Tract Symptoms Following Rhinovirus Challenge PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vapendavir (VPV) is a drug being developed to treat human rhinovirus (RV) infection, one virus responsible for the common cold. Vapendavir prevents the virus from entering cells and making more infectious copies of itself. A study is being planned to investigate VPV in patients with chronic obstructive pulmonary disease (COPD, a lung disease making it difficult to breathe) who develop a rhinoviral infection; however, VPV has not been approved for use in treating any indication (disease) by the FDA or any other global regulatory agency. Therefore, VPV is considered investigational, … |
ONN MIN KON; | 2023-11-20 |
| 216 | Effect of The Inhaled Triple Therapies Over The Small Airway in Patients With Chronic Obstructive Pulmonary Disease or Chronic Bronchitis Without Obstruction Secondary to Biomass Exposure: Randomized Controlled Clinical Trial Phase IV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase IV randomized controlled clinical trial intend to compare the effect of three close standard inhaled triple therapies and one close standard inhaled double therapy on the small airway in patients with Chronic Obstructive Pulmonary Disease (COPD-B) and chronic bronchitis without obstruction (BCNO) exposed to wood smoke. The treatment phase duration is of 3 months. As primary outcome, the resistance change in post-bronchodilatator impulse oscilometry will me measure at 30 minutes, 2 hours, 4 hours, and 24 hours post first dose of the asigned medication, and then at 1 and 3 months of treatment. As secondary outcomes, … |
NATIONAL INSTITUTE OF RESPIRATORY DISEASES MEXICO | 2023-11-15 |
| 217 | Effect of Thyme Oil on Respiratory Symptoms and Hemodynamic Parameters in COPD Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a high-prevalence, preventable and treatable disease characterized by abnormal respiratory symptoms and airway obstruction, often resulting from exposure to hazardous substances due to airway and/or alveolar abnormalities. The disease is an important problem with high morbidity and mortality rates all over the world and in our country. COPD is known as the third disease with a high mortality rate and the sixth disabling disease worldwide. The Global Burden of Disease Study reports 251 million cases of COPD worldwide in 2016. According to World Health Organization (WHO) data, … |
ZELIHA CENGİZ; | 2023-11-15 |
| 218 | Impacts of Aminophylline on Perioperative Lung Mechanics in COPD Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery: A Prospective Randomized Double Blinded Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the usefulness of adding aminophylline to dexmedetomidine intravenous infusion intraoperatively on oxygenation and lung mechanics in chronic obstructive pulmonary disease (COPD) morbidly obese patients undergoing bariatric surgery. |
SOLIMAN RAMADAN AHMED NASER; | 2023-11-11 |
| 219 | Pattern of Micro-bacterial Infection and Its Sensitivity to Antibiotics in COPD Patients With Acute Exacerbation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Measurement of bacterial species causing AECOPD and their Sensitivity pattern to antibiotics. |
MARIAM NAZIF ABDEL-TAWAB MOUSA; | 2023-11-01 |
| 220 | A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Study on The Efficacy and Safety of Xuanfei Baidu Granule in The Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective,multicenter, randomized, double-blind, placebo-controlled trial. This study plans to enroll 375 participants who will be randomly assigned in a 2:1 ratio. On the basis of basic treatment, one group will receive Xuanfei Baidu granule, while the other group will receive Xuanfei Baidu granule placebo, with one sachet in the morning and one in the evening, for a duration of 7 days. Visits will be conducted on days 7, 14, and 21 after enrollment. If any participant experiences an acute exacerbation of chronic obstructive pulmonary disease (COPD) requiring hospitalization during the treatment period, … |
CUILING FENG; | 2023-11-01 |
| 221 | A Multi-Centered, Randomized, Double-Blinded, Placebo-Controlled Phase II Clinical Trial, to Evaluate The Efficacy and Safety of 611 in Chinese Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study was to evaluate the efficacy and safety of 611 in Chinese adults with moderate to severe COPD. |
TING YANG; | 2023-11-01 |
| 222 | Chronic Obstructive Pulmonary Disease: A Multi-center Supervised Tele-rehabilitation Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease(COPD) patients could benefit from pulmonary rehabilitation(PR) in better managing of the disease and its symptoms and in avoiding future relapses and hospitalizations. However, due to a large number of drop outs from PR, lack of professionals, and the (Corona Virus Disease 2019) COVID-19 epidemic, the PR has been underutilized, leading to a need for investigation of updated forms. The study aims to investigate the effects of a home-based PR program using minimal accessories, facilitated with wearable activity trackers and smartphones. |
TING YANG; | 2023-11-01 |
| 223 | Reflections of Oxygen Delivery Methods Applied in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD) on Blood Gas and Spirometer Measurements PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine the effects of oxygen therapy methods applied as indicated in COPD acute exacerbations on blood gas results and spirometric measurements. |
EMINE SARCAN; | 2023-11-01 |
| 224 | Investigation of The Validity and Reliability of The Londrina Activities of Daily Living Protocol in Idiopathic Pulmonary Fibrosis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Londrina Activities of Daily Living Protocol was first developed for Chronic Obstructive Pulmonary Disease patients and was found to be valid and reliable, but there is no validity and reliability study of the Londrina Activities of Daily Living Protocol in IPF patients. The purpose of the study is to Examine the Validity and Reliability of the Londrina Activities of Daily Living Protocol in Idiopathic Pulmonary Fibrosis (IPF) patients. |
ILKNUR NAZ; | 2023-11-01 |
| 225 | Impact of Switching COPD Patients From Inhaler Devices to The Omron C28P Nebuliser: A Prospective, Real-world Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The cornerstone of COPD therapy is based on the use of inhalation drugs. The correct use of devices is crucial; a suboptimal use technique is the cause of a possible clinical deterioration with a consequent increase in exacerbations and healthcare expenditure. Inhalation of drugs by nebulizer, in specific populations of patients who have shown poor adherence to inhalation therapy and poor symptomatological control, could be a more advantageous therapeutic strategy than pMDIs or DPIs, … |
BONINI MATTEO; | 2023-11-01 |
| 226 | The PACED Study: A Randomized Controlled Pilot Study of Palliative Care Education Compared to Usual Care on Health Literacy and Quality of Life Among Older Adults With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot randomized controlled trial is to compare health literacy (HL) and quality of life (QOL) among older adults with chronic obstructive pulmonary disease (COPD) who completed a series of standardized palliative care (PC) educational video learning modules to usual care (US). The main question[s] it aims to answer are: Between Groups: – What effect does completing a series of standardized PC education video learning modules have on HL among older adults with COPD treated in the emergency department (ED) compared to usual care? – … |
KELLY COUNTS; | 2023-11-01 |
| 227 | Nutritional Supplementation With Indirect Calorimetry During Pulmonary Rehabilitation in Patients With Chronic Respiratory Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the nutritional status of patients with chronic pulmonary disease undergoing regular outpatient pulmonary rehabilitation. |
KE-YUN CHAO; | 2023-10-30 |
| 228 | The Role of Expectations in Chronic Obstructive Pulmonary Disease (COPD) – Development and Validation of A New Tool PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the impact of expectations on individuals with Chronic Obstructive Pulmonary Disease (COPD) and aims to develop and validate a novel tool to assess these expectations. By understanding the role of expectations, healthcare providers can better tailor interventions and support for COPD patients, ultimately improving their quality of life and treatment outcomes. |
ELEONORA VOLPATO; | 2023-10-30 |
| 229 | Development and Feasibility Testing of Digital Theory-based Pursed Lip Breathing in Stable Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pre-post design clinical trial is to develop a digital, theory-based Pursed Lip Breathing intervention protocol software system installed on smartphones (DT-PLB) and to preliminarily evaluate its feasibility and effects in stable Chronic Obstructive Pulmonary Disease (COPD). The main objectives are: 1. To develop a digital, theory-based Pursed Lip Breathing intervention protocol software system installed on smartphones for managing breathing exercises in stable COPD patients. 2. To pilot the methodological procedures of the pre-post study. 3. To determine the recruitment rate, retention rate, attrition rate, … |
HOUQIANG HUANG; | 2023-10-30 |
| 230 | Balance, Walking Speed, Quadriceps Femoris Muscle Strength and Quality of Life in Falling and Non-falling Individuals With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A descriptive study evaluating balance, gait speed, Quadriceps Femoris muscle strength and quality of life in individuals with Chronic obstructive pulmonary disease (COPD) who fell and did not fall. |
MERAL SERTEL; | 2023-10-30 |
| 231 | A Double-Blind, Multicentre, Randomized, Three-Period, Three-Treatment, Cross-Over Study to Evaluate The Effect of BGF MDI, BFF MDI, and Placebo MDI on Exercise Parameters in Participants With COPD (ATHLOS) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate the effect of Budesonide, Glycopyrronium, and Formoterol Fumarate (BGF) metered dose inhaler (MDI) compared with Placebo MDI, and Budesonide and Formoterol Fumarate (BFF) MDI on isotime inspiratory capacity (IC) and exercise endurance time. |
ASTRAZENECA | 2023-10-24 |
| 232 | Examination of The Effect of Handhaler Tiotropium, A Long-acting Anticholinergic, on Anterior Chamber Parameters PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to examine the effect of Tiotropium, which is used in the treatment of COPD, on eye symptoms.The study was conducted prospectively. Patients were examined in three groups. Thirty-six patients were included in each group in the study. Anterior chamber parameters, intraocular pressure values, and photopic-mesopic pupil diameters were measured at the initial visit for Group 1 and Group 2 patients, and at the third month of treatment for Group 3 patients. |
HAYRIYE BEKTAŞ; | 2023-10-23 |
| 233 | Role Of LDCT Chest In Assessment Of Apparently Healthy Smokers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the effectiveness of LDCT screening in detecting early-stage lung cancers among smokers who do not have symptoms of lung disease. |
HEND MOHAMED SAYED MOHAMED; | 2023-10-20 |
| 234 | Improvement of Pulmonary Function in Hemiplegic Cerebral Palsied Children By Using Hydrotherapy and Aerobic Exercises Related Papers Related Patents Related Grants Related Experts View Highlight: Cerebral palsy (CP) is the most common motor disability in childhood. Respiratory muscle weakness and a low upper to lower chest diameter ratio are common respiratory dysfunction manifestations in those children which negatively affect their quality of life.. |
RAGAEE SAEED MAHMOUD; | 2023-10-15 |
| 235 | A Pharmacist-Led Intervention on Medication Adherence and Inhaler Usage on Clinical Outcomes Among Patients With Asthma and Chronic Obstructive Pulmonary Disease in Ibadan, Nigeria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the impact of a pharmacist-led intervention programme on medication adherence and use of inhaler devices on clinical outcomes of patients with asthma and COPD attending a tertiary health facility in Nigeria. |
UYIOSE FORTRESS UFUAH; | 2023-10-04 |
| 236 | Pattern and Outcome of Respiratory Diseases in Patients Admitted in The Chest Department at Assiut University Hospital PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to determine the pattern and outcome of respiratory diseases in adults patients admitted to the Department of Chest Diseases at Assiut University Hospital. |
FATMA HAMDAN ZAKI ADEEL; | 2023-10-01 |
| 237 | Clinical Study for The Effectiveness of Roflumilast Treatment in COPD Greek Patients Based on Standard Clinical Practice. An Observational, Non-interventional Multicenter Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Preferred pharmacological management for COPD according to the GOLD guidelines are the long-acting anticholinergic LAMAs (Long-Acting / Short-Acting Muscarinic Antagonists), and long-acting β 2-Agonists LABA (Long-acting LABA) / β2-Long Action Fighters) as well as inhaled corticosteroids (ICS) Other drugs that can be used besides long-acting, are short-acting anticholinergics (SAMA) and β2-agonists (SABA), methylxanthines (Aminophylline and Theophylline), mucolytics and phosphodiesterase inhibitors 4 (Phosphorus) of which is roflumilast |
ELPEN PHARMACEUTICAL | 2023-10-01 |
| 238 | Role of Clopidogrel in Preventing Exacerbations in Patients With Severe COPD: An Open-label Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a debilitating respiratory disorder characterized by gradual and progressive airflow limitation. It has been hypothesized that clopidogrel may have role in reducing the exacerbation of COPD by reducing thromboembolic events. Several observational studies have found that taking clopidogrel reduces the likelihood of COPD exacerbations in patients with the disease. The study being conducted will be a randomized control trial, from March 2023 to March 2024 in department of pulmonology, … |
MUHAMMAD IMRAN; | 2023-10-01 |
| 239 | Clinical Characteristics and Predictors of Pulmonary Hypertension in COPD at Different Levels of Smoking PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To identify Predictors of pulmonary hypertension in COPD patients and its relation to different levels of smoking |
SHROUK MOHAMED SALAH MOSLEH; | 2023-10-01 |
| 240 | SIRT1(rs7069102 ) Gene Polymorphism in Chronic Obstructive Pulmonary Disease at Egyptian Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) prevalence, morbidity, and mortality vary across countries and across different groups within countries with a direct relation to the prevalence of tobacco smoking. Other risk factors for COPD include genetic factors, longstanding asthma, outdoor air pollution, second-hand smoke exposure, biomass smoke, indoor air pollution, occupational exposures, and tuberculosis . The prevalence and burden of COPD are projected to increase in the coming decades because of continued exposure to COPD risk factors and the changing age structure of the world’s population. As these factors are rapidly increasing in developing countries, … |
ZAINAB MAHMOUD KADRY; | 2023-10-01 |
| 241 | Effect Of Obesity on The Outcome Of Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study the relationship between the body mass index and duration of mechanical ventilation & complications in mechanically ventilated COPD patients. Study the effect of obesity on mortality rate of COPD mechanically ventilated patients. Determine prevalence of obesity in mechanically ventilated COPD patients. |
ASMAA GAMAL ABD ELHAMIED; | 2023-10-01 |
| 242 | Examination of The Relationship Between Clinical Variables and Dyspnea and Fear of Movement in Chronic Obstructive Pulmonary Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients diagnosed with COPD who applied to the Pulmonary Diseases Department of Kırıkkale Yüksek İhtisas Hospital will be included in the study. The aim of our study: It is aimed to investigate the effect of fear of movement due to dyspnea on respiratory function, muscle strength, physical performance and balance in Chronic Obstructive Pulmonary Disease Patients. |
SANIYE AYDOĞAN ARSLAN; | 2023-10-01 |
| 243 | Evaluation of The Concept Can Do Versus Do Do in Patients With Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Breast cancer occurs as a result of uncontrolled proliferation of cells in the breast tissue. Breast cancer is the most common type of cancer among women worldwide and is an important problem that threatens women’s lives. The incidence rate has reached approximately 16 Breast cancer treatment consists of local and systemic therapies. While local treatments include surgery and radiotherapy, systemic treatments, which are administered in two different ways, namely adjuvant and neoadjuvant systemic treatments, consist of chemotherapy, hormone therapy and targeted biological therapies. Although the treatment options for breast cancer are increasing day by day, … |
EBRU CALIK KUTUKCU; | 2023-09-30 |
| 244 | Randomized, Parallel Group, Phase III, Non-inferiority Study Comparing Ipratropium / Levosalbutamol Fixed Dose Combination in PMDI Form and Ipratropium and Salbutamol Free Dose Combination in PMDI Form in Stable Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the acute bronchodilator effect of pMDI formed Ipratropium / Levosalbutamol 20 mcg / 50 mcg fixed dose combination or pMDI formed Salbutamol 100 mcg Inhaler and Ipratropium 20 mcg Inhalation Aerosol in combination in stable moderate-severe-very severe COPD patients. |
NEUTEC AR GE SAN VE TIC A Ş | 2023-09-28 |
| 245 | A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate The Efficacy and Safety of Tozorakimab in Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With A History of COPD Exacerbations (MIRANDA) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab administered subcutaneously (SC) in adult participants with symptomatic COPD with a history of ≥ 2 moderate or ≥ 1 severe exacerbations of COPD in the 12 months prior to enrolment. Participants should be receiving optimised treatment with inhaled maintenance therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) throughout at least the last 3 months prior to enrolment. |
ASTRAZENECA | 2023-09-22 |
| 246 | Comparison of Blow Bottle Positive Expiratory Pressure (BBPE) Versus Acapella on Oxygenation,Peak Expiratory Flow Rate (PEFR) Among Patient With Chronic Bronchitis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparison of Blow Bottle Positive Expiratory pressure(BBPEP) versus Acapella on Oxygenation ,peak Expiratory Flow Rate(PEFR)among patient with chronic bronchitis. |
SUMERA ABDULHAMEED; | 2023-09-20 |
| 247 | Clinical and Medico-economic Study to Validate The Performance of A Digital and Personalized Solution (HEPHAÏ) to Support The Use of Inhaled Treatments for Asthma and COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In a context where the use of inhalation devices for respiratory medications is associated with a high frequency of critical errors, our primary hypothesis is that the use of the HEPHAÏ solution reduces this frequency compared to standard care. The objective of this clinical study is to evaluate the performance of the HEPHAÏ solution as a tool for improving the administration of inhaled treatments in patients undergoing pulmonary care for asthma and/or COPD, … |
CAPUCINE CAPUCINE.MORELOT@APHP.FR; | 2023-09-19 |
| 248 | Effectiveness and Cost-effectiveness of An Integrated Psychological Internet Intervention (MindWellness) in Chinese COPD Patients: Study Protocol of A Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Background Mental health problems in chronic obstructive pulmonary disease (COPD) patients are prominent and neglected. Web-based self-help therapies may effectively reduce mental health problems, but their effectiveness has not been evaluated in Chinese COPD patients. We developed an integrated Internet-based psychological intervention (MindWellness). This study aims to evaluate the effectiveness and cost-effectiveness of MindWellness in enhancing the mental wellbeing of COPD patients. Methods This study is a multicenter, two-arm, … |
SIMIAO CHEN; | 2023-09-15 |
| 249 | The Effect of Pursed Lip Breathing Exercise and Laughter Therapy on Dyspnea, Health Status, and Care Dependence in Individuals With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease is a chronic disease with increasing mortality, morbidity and prevalence in the world and in our country, and in which serious symptoms, especially dyspnea, develop. Due to dyspnea and symptoms, patients experience deterioration in their health status and an increase in care dependency. This research is a single-blind, randomized controlled experimental study designed to determine the effects of pursed lip breathing exercise and laughter therapy on dyspnea severity, … |
GONCAGUL ALDAN; | 2023-09-15 |
| 250 | Evaluation of Motor Imagery, Cognitive Function and Reaction Time in Children With Bronchiectasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to evaluate motor imagery ability, reaction time and cognitive function parameters in children with CF and non-CF bronchiectasis compared to healthy peers. |
HILAL DENIZOĞLU KÜLLI; | 2023-09-05 |
| 251 | Etiology Analysis of Chronic Cough After COVID-19 Infection and Research on The Efficacy of ICS or ICS/LABA PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study collected 600 patients, evaluated whether patients had airway hyperreactivity, airway inflammation, specific types and allergic reactions, comprehensively analyzed and classified the causes of chronic cough in patients, and evaluated and compared the improvement of cough symptoms and quality of life after ICS or ICS/LABA treatment. |
JUAN JIANG; | 2023-09-01 |
| 252 | Sarcopenia Screening in Elderly Individuals Living in Kirikkale Province PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, it is aimed to evaluate parameters such as sarcopenia screening, muscle mass measurement, loss of strength that may develop due to sarcopenia, loss of balance and related fall, decrease in functionality, fragility and decreased physical activity in individuals aged 65 years and older in Kırıkkale city center. |
SEYMA AKDAGLI; | 2023-09-01 |
| 253 | The Effectiveness of Harmonica Playing in Improving Lung Function Among In-home Patients With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Although it has been documented that harmonica playing plays a role in the pulmonary rehabilitation (PR) of patients with chronic obstructive pulmonary disease (COPD), current studies are limited by small sample sizes, uncomprehensive outcome indicators, and short intervention durations. Thus, the investigators aim to compare the harmonica combination group with the basic-PR-care group in terms of improving health outcomes among COPD patients, such as lung function, self-efficacy, quality of life, compliance with training, and emotional distress. |
ZENG QIUXUAN; | 2023-09-01 |
| 254 | The Impact of Education on The Rehabilitation of Patients Hospitalized Due to Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The planned research will enable the assessment of rehabilitation’s effects using two pulmonary rehabilitation models: conventional and supplemented with an education program for patients hospitalized due to chronic obstructive pulmonary disease. |
RENATA BORYS; | 2023-09-01 |
| 255 | Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Study Aim is creation of the Hospital Register of patients with heart failure with preserved ejection fraction (HFpEF) for a comprehensive assessment of the influence of gender characteristics, clinical and anamnestic factors, body composition, topical characteristics of congestion, instrumental data and markers of cellular inflammation and stress on immediate and long-term outcomes in patients with acute decompensated heart failure with preserved ejection fraction. During the study it is planned to assess gender, clinical and anamnestic indicators preceding hospitalization of patients in the hospital; characterize the features of comorbid status in the studied group of patient; … |
YURY TIMFEEV; | 2023-09-01 |
| 256 | A High-Flow Nasal Cannula Versus Noninvasive Ventilation in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Single-blind Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators investigated the efficacy and safety of High Flow Nasal Cannula (HFNC) at different flow rates compared to non-invasive ventilation (NIV) in patients presenting to the emergency department (ED) with acute exacerbations of Chronic obstructive pulmonary disease (COPD) who did not respond adequately to bronchodilator therapy and continued to exhibit hypercapnic respiratory failure. Specifically, the investigators tested the hypothesis that HFNC would be more effective at reducing partial pressure of carbon dioxide (PaCO2) levels and hospital stay duration and would be associated with greater patient comfort than NIV. |
ADEM AZ; | 2023-09-01 |
| 257 | Effects of A Decision Support Intervention on End-of-life Care Planning in Patients With Advanced Chronic Obstructive Pulmonary Disease and Their Family Members: A Mixed Method Approach PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to support EOL decision-making in patients with advanced COPD and their family members. A parallel two-arm single-blinded randomised controlled trial will be conducted to evaluate the effects of a specific decision support intervention. A total of 226 patients with advanced COPD and their designated family members will be recruited from hospital wards and outpatient clinics. |
HELEN YL CHAN; | 2023-09-01 |
| 258 | Novel Predictors of Premature Aging in COPD Patients: SCINEXA Score and Laboratory Markers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: •Examine whether COPD is associated with accelerated aging using a biological marker of aging and dermatological score |
SAHAR REFAAT MAHMOUD; | 2023-09-01 |
| 259 | Effects of Deep Breathing Exercise on Pulmonary Function, Perceived Stress and Physical Fitness Among Healthy Smokers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Effects of deep breathing exercise on pulmonary function, perceived stress and physical fitness among healthy smokers. |
MALIK MUHAMMAD ALI AWAN; | 2023-09-01 |
| 260 | Evaluation of Nasal IL 1 Beta ,IL 3 Level and Their Effects on Disease Severity in COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease is associated with systemic and local inflammation. exposure to harmful gases and particles play important role in initiating the inflammatory processes leading to the development of COPD. In high- and medium-income countries, tobacco smoking is considered the predominant source of these noxious elements.1 Asthma, COPD, rhinitis and rhinosinusitis (RS) are chronic diseases of the respiratory tract with an estimated global prevalence of about 12%.2The concept of united airways diseases (UAD) was formulated on the initial observation of the coexistence of allergic rhinitis and chronic rhinosinusitis with asthma.3 |
NERMEN ABUELKASSEM; | 2023-09-01 |
| 261 | An Investigator-Initiated, Single Center, Prospective, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate Safety and Efficacy of OnabotulinumtoxinA (BOTOX®) in Adults With Moderate Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial to determine the safety and effectiveness of treating the COPD symptoms with subcutaneous BOTOX injections in participants with moderate COPD. |
VICTORIA DO; | 2023-09-01 |
| 262 | Right Ventricle Dysfunction in Critically Ill Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess prevalence of right ventricle dysfunction in critically ill patient. To assess impact of RV dysfunction on short term (ICU stay, hospital stay, or mortality ≤30 days) and long term outcome (>30 days). To assess the accuracy of different parameters of RV dysfunction. |
MUSTAFA SHABAN ABDELSALAM THABET; | 2023-08-30 |
| 263 | Manual Hyperinflation Versus Diaphragmatic Proprioceptive Neuromuscular Facilitation on Pulmonary Functions in Mechanically Ventilated Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: the goal of this clinical trial is to compare between to important physiotherapy modalities applied on mechanically ventilated COPD patients the the main question the study aim to answer is which one of the two modalities has the better effect on mechanically ventilated patients with COPD patients will get manual hyperinflation technique and PNF technique \ researchers will compare MHI with PNF and will take a control group also |
OMAR HASHAM MOHAMED; | 2023-08-30 |
| 264 | The Enhanced Pulmonary Rehabilitation Program With Digital Remote Patient Monitoring: A Feasibility Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the current randomized controlled trial is to assess feasibility of integrating digital remote patient monitoring (dRPM) with the an enhanced Breathe Easy Pulmonary Rehabilitation Program for Individuals with COPD and Comorbidities (BEPR+), including aspects such as recruitment, retention, patient adherence, technology acceptability, adverse events, and staffing resources. The secondary objectives include comparing clinical outcomes (such as functional capacity, health status, quality of life, self-management, psychosocial health, physical activity and self-efficacy) between those who receive dRPM and BEPR+ (dRPM+) vs. those who receive BEPR+ alone. |
MICHAEL STICKLAND; | 2023-08-29 |
| 265 | Sample Collection for Biosensor Development Using Real-world Conditions with Exposure to urban Versus clean Air in Healthy Subjects and COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this proof-of-concept study is to obtain data that will contribute to the development of sensor devices (biosensor and environmental sensor) for patients with lung diseases (e.g. COPD). The study aims to validate our previous results from healthy subjects by joint testing of the biosensor and environmental device in a real-world setting. Healthy subjects and COPD subjects will be exposed to air of a traffic dense urban region (urban air) and to filtered indoor air (clean air) during activity and rest. Environmental and biomarker sensors will be used to measure several biomarkers and environmental conditions. |
FRAUNHOFER INSTITUTE OF TOXICOLOGY AND EXPERIMENTAL MEDICINE | 2023-08-28 |
| 266 | EFFECT OF PRANAYAMA YOGA ON SYMPTOMS, FATIGUE AND RESPIRATORY PARAMETERS IN INDIVIDUALS WITH COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study In this study, pranayama yoga practices are the sub-dimensions of respiratory parameters, symptom and disease affection level, psychosocial adjustment and psychosocial adjustment in individuals with COPD. It was planned in a randomized controlled manner to examine the effects of healthcare compliance, professional environment, family environment, sexual relations, extended family relationships, … |
YEDITEPE UNIVERSITY | 2023-08-25 |
| 267 | Randomized, Double-blind, Placebo-controlled, Dose Exploration, Multicenter Phase II Clinical Trial to Evaluate The Efficacy and Safety of TQC3721 Suspension for Inhalation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II clinical trial to evaluate the efficacy and safety of TQC3721 Suspension for Inhalation in patients with moderate to severe Chronic obstructive pulmonary disease (COPD). |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2023-08-23 |
| 268 | Effects of Blow Bottle Verses ACBTs Technique in Patients of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease is a common disease worldwide. Pulmonary rehabilitation is an important part to decrease the complications of COPD. Blow bottle technique is an economical and subjective technique promote the lung expansion, as compare to ACBTs. It used to treat the different complications in COPD patients and also decrease the dependency of patient. To find the comparative effects of blow bottle and active cycle of breathing on sputum diary, oxygen saturation, … |
WAJEEHA ZIA; | 2023-08-18 |
| 269 | The Acute and Chronic Benefits of Passive Heat Therapy for People With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: People with Chronic Obstructive Pulmonary Disease (COPD) often develop high blood pressure and heart disease due to their sedentary lifestyle and difficulty exercising. The investigators will test if heating can mimic the health benefits of exercise by monitoring the increase in leg blood-flow using ultrasound during a 45-minute hot-water footbath. The patients will then undergo 6-weeks of hot-water footbaths to examine whether the changes to blood-flow lead to improvements in blood pressure and other indicators of heart disease risk. |
NEIL EVES; | 2023-08-17 |
| 270 | COPD Case Finding In Nottingham and District: C-FIND COPD A Pilot Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The Targeted Lung Health Check (TLHC) is currently being rolled out in many regions of the United Kingdom and has just started in Nottingham. The same cohort of people are also at high risk for Chronic Obstructive Pulmonary Disease (COPD), a lung condition often caused by smoking and leading to breathlessness and cough. This study aims to provide pilot evidence of the role of breathing tests in those who have had a Computerised Tomography (CT) scan, in order to early diagnose COPD. Currently, at diagnosis, many patients have lost 30-40% of lung function already, … |
CHARLOTTE BOLTON; | 2023-08-15 |
| 271 | Thoracic Spinal Versus Thoracic Epidural Anesthesia for Patients with Chronic Obstructive Pulmonary Disease Undergoing Supine Percutaneous Nephrolithotomy for Management of Renal Stones. A Prospective Double-blind Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Owing to the elevated risk of perioperative comorbidities, chronic obstructive and restrictive pulmonary disorders can be a challenging task for the anesthetist. Endotracheal intubation and intermittent positive pressure ventilation (IPPV), two hallmarks of general anesthesia (GA), are known to increase the risk of serious complications such as barotrauma, laryngospasm, … |
FOUAD SOLIMAN; | 2023-08-15 |
| 272 | The Effect of Sodium Pyruvate Nasal Spray on Coughing in Patients With Idiopathic Pulmonary Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to administer a sodium pyruvate nasal spray that eliminates nasal oxidative stresses, caused by oxygen radicals, and demonstrate the efficacy of sodium pyruvate to reduce coughing and increase lung functions in patients with idiopathic pulmonary fibrosis. This will be a 21-day double-blinded randomized placebo-controlled trial designed to determine if patients with idiopathic pulmonary fibrosis treated with 20mM sodium pyruvate in 0.9% sodium chloride nasal spray solution will have reduced chronic coughing, as well as increased lung function (FEV1, FVC endpoints of 12% or more within the first week) and improved FEV1/FVC ratios. |
MANUEL M LAM; | 2023-08-15 |
| 273 | Online-adaptive Radiotherapy in Lung Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In patients with lung carcinoma who receive radiotherapy preoperatively or alternatively curative, high-dose radiotherapy instead of surgery, there are also deformations of the thorax from fraction to fraction. Currently, ART for lung carcinomas is carried out as part of patient care in the radiotherapy clinic. Patients are irradiated during repeated breath-holding manoeuvres in deep inspiration. The breath-holding manoeuvre is practised several times before the daily irradiation. An optical surface detection device is available for this purpose, … |
UNIVERSITY HOSPITAL ESSEN | 2023-08-02 |
| 274 | Determination of The Minimal Clinically Significant Difference (MCID) of Multidimensional Dyspnea Profile (MDP) Scores in Chronic Obstructive Pulmonary Disease (COPD) Patients During Pulmonary Rehabilitation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to determine the individual threshold of minimal clinical change (MCID) for each component of the Multidimensional Dyspnea Profile (MDP) questionnaire in COPD patients undergoing pulmonary rehabilitation. |
CAPUCINE MORELOT-PANZINI; | 2023-08-01 |
| 275 | Exploring Gas Transfer and The Utility of Dynamic Chest Radiography in Long Covid Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to identify if breathless patients with Long COVID have reduced transfer factor on pulmonary function testing and if the degree of transfer factor reduction is correlated with the symptom severity and physiological ability to exercise. We will also investigate whether a new type of X-ray called a dynamic chest X-ray can identify perfusion abnormalities and whether these correlate with differences in diffusion capacity measured on a pulmonary function test. |
LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST | 2023-08-01 |
| 276 | Evaluation of The Usefulness and Efficacy of Telemonitoring of Patients With COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A substantial number of people with COPD suffer from exacerbations, which are defined as an acute worsening of respiratory symptoms. To minimize exacerbations, telehealth has emerged as an alternative to improve clinical management, access to health care, and support for self-management. The study objective was to map the evidence of telehealth/telemedicine for the monitoring of adult COPD patients after hospitalization due to an exacerbation. |
SEMIR NOUIRA; | 2023-08-01 |
| 277 | Impact of Lung Hyperinflation on The Response to Pulmonary Vasodilator Therapy in Patients with Pulmonary Hypertension (PH) Associated with Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD). The study will include all patients from the hospital, followed for pulmonary hypertension associated with COPD under vasodilator therapy between 2015 and 2021. |
ARI CHAOUAT; | 2023-08-01 |
| 278 | Home-based Body Weight Exercise With Blood Flow Restriction (BFR): Feasibility of A Novel Rehabilitation Intervention in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this randomised controlled trial is to investigate the feasibility and acceptability of low-intensity exercise with blood flow restriction (BFR) in patients with Chronic Obstructive Pulmonary disease (COPD). The investigators will also collect functional and physiological outcome data to explore potential mechanisms and provide data for a power calculation to be used in a future randomised controlled trial (RCT) to ensure that subsequent full scale clinical RCT has maximum reach and benefit. The primary experimental hypothesis that underpins these aims is: • Low-intensity exercise with BFR is a tolerable, acceptable, … |
MRS HANOOF ALJOHANI; | 2023-08-01 |
| 279 | A Real-world, Multicenter, 52-week Prospective Cohort Study to Capture The Reasons for Switch to Triple Combination Therapy and to Assess The Clinical and Patient Reported Outcomes in Adults With Moderate to Severe COPD Treated With Trixeo Aerosphere™ in Routine Care Settings in Greece PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a debilitating and progressive respiratory condition characterized by irreversible airflow limitation. The overall 5-year survival for COPD patients is 56-92%, depending on disease severity. Considering the recent introduction of the Budesonide, Glycopyrronium bromide and Formoterol fumarate Metered-Dose Inhaler (BGF MDI) in COPD therapeutic arsenal as well as the increasingly important role of real-world (RW) data in health care decisions, as it bridges gaps not addressed by randomized clinical trials, there is a need for RW evidence studies that can serve as inputs for Health Technology Assessment (HTA) submissions. In view of this need, … |
ASTRAZENECA | 2023-07-21 |
| 280 | Effect of Senobi Breathing Exercise Versus Buteyko Breathing Technique on The Functional Performance Among Chronic Obstructive Pulmonary Disease Patient PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Effect of Senobi breathing exercise versus Buteyko breathing technique on functional performance among chronic obstructive pulmonary patient. |
SUMERA ABDULHAMEED; | 2023-07-20 |
| 281 | Comparison of Jacobson Relaxation Technique and Pranayama Technique in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Chronic obstructive pulmonary disease is a chronic inflammatory lung disease that cause obstructed airflow from the lungs. Symptoms include Breathing difficulty. cough, mucus … |
SUMERA HAMEED; | 2023-07-20 |
| 282 | An Investigation of The Physiological and Psychosocial Mechanisms Underpinning Balance Impairment in People With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an observational study investigating the mechanisms of balance problems in people with COPD and how COPD impacts them living their daily lives. The main objectives of this study are: – To quantify the relationship between balance and aspects of neuromuscular function in individuals with COPD, and compared to age-matched healthy controls – To understand the lived experience of people with COPD and their carers Participants will attend an appointment at the University rehab lab to: – Complete a balance test – Fill out some questionnaires on mood, health status and balance and falls – … |
SAMANTHA HARRISON; | 2023-07-17 |
| 283 | A Randomized Controlled Trial Comparing Diagnostic Performance of Primary Care Clinicians in The Interpretation of SPIROmetry With or Without Artificial Intelligence Decision Support Software PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate whether an artificial intelligence decision support software (ArtiQ.Spiro) improves the diagnostic accuracy of spirometry interpreted by primary care clinicians, as measured by Clinician Diagnostic Accuracy (vs Reference Standard). |
WILL MAN; | 2023-07-15 |
| 284 | Comparative Effects of Anterior Chest Compression Assist and Abdominal Thrust Assist Technique on Sputum Diary, Oxygen Saturation, Expiratory Flow Rate, and Dyspnea in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A total 34 patients will be taken. 2 groups will be created to apply intervention. After signing consent form, 17 patients in group A will be given abdominal thrust assist technique and 17 patients in group B will be given anterior chest compression technique. |
SIDRA FAISAL; | 2023-07-15 |
| 285 | A Wearable In-phase Chest Wall Vibration Device for Relief of Dyspnoea in COPD: A First-in-human Exploratory Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this exploratory clinical trial is to evaluate the initial clinical safety and performance of a prototype wearable chest wall vibration (CWV) device intended to relieve exertional dyspnea in adults with Chronic Obstructive Pulmonary Disease. The main questions it aims to answer are: – Can CWV be delivered safely to participants via a wearable device? – Is there evidence of an effect on participant-reported dyspnea, … |
ELEVRE MEDICAL | 2023-07-06 |
| 286 | Combined Effects of Blow Bottle Technique and Percussion Technique in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It will be a randomized control trial. Participants will be recruited according to inclusion criteria and will be allocated into 2 groups using convenience sampling technique. Group 1 will be treated with percussion technique for 30 min and group 2 with blow bottle technique combined with percussion technique for 30 min at DHQ Teaching Hospital Gujranwala. Intervention will be carried out for total 4 weeks of duration with 3 sessions per week. Outcome measures such as dyspnea, breathlessness, sputum and cough, O2 and pulse rate, expiratory flow rate will be measured by tools as mMRC, BCSS, … |
SIDRA AFZAL; | 2023-07-05 |
| 287 | Comparative Effects of Active Cycle of Breathing Techniques and Slow Expiration With Open Glottis in Lateral Posture in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is characterized by nonreversible airway obstruction. A diagnosis of COPD is determined by clinical assessment of airflow limitation and symptoms such as cough and wheeze; however, the detrimental effect of COPD symptoms on a patient’s quality of life is often underestimated. Rehabilitation exercise can lessen the possibility of the progressive exacerbation of the patient’s condition, exerting an active role in improving their lung function and the quality of the patients’ life .Therefore, Active cycle breathing techniques (ACBT) is a cycle of techniques consisting of breathing control, … |
SIDRA AFZAL; | 2023-07-05 |
| 288 | Comparative Effects of Costophrenic Assisted Cough and Anterior Chest Compression Technique on Sputum Diary, Oxygen Saturation, Expiratory Flow Rate, and Dyspnea in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production and wheezing. In Costophrenic assist, the therapist gives a quick stretch to the diaphragm and intercostals with repetitions. The patientt holds air in the lungs. As the patient gets ready to cough, the therapist performs a diaphragmatic assist. In Anterior chest compression: the therapist places one arm across the patient’s pectorals and the other parallel to it. After the patient takes a maximal breath, … |
SIDRA AFZAL; | 2023-07-05 |
| 289 | Combined Effects of Active Cycle of Breathing Technique and Autogenic Drainage in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomised controlled trial will be conducted with COPD patients as its target population. There will be 40 individuals for both the control group and the intervention group. Group A is a control group while Group B is an experimental group (20 participants on Group A and 20 on group B). The baseline treatment for both groups were pursed lip breathing and ACBT. On the other hand, … |
SIDRA AFZAL; | 2023-07-05 |
| 290 | Impact of Fixed TRIple Therapy With Beclometasone/Formoterol/Glycopyrronium DPI (Trimbow® in NEXThaler Device) in Chronic Obstructive PulmoNary Disease in REal-world Settings: Health-related Quality of Life Patient’ EXpectations and CharacterisTics: The TriNEXT Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational, prospective, multicentric, cohort study conducted in France to evaluate the QoL in COPD patients treated with TRIMBOW NEXThaler 88/5/9 in a routine clinical practice setting. Patients enrolled in this study will be patients diagnosed with a COPD with a ratio of post-bronchodilator (salbutamol 400 μg) forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) of less than 0.7 to whom TRIMBOW NEXThaler 88/5/9 has been initiated by an hospital or local pulmonologists in accordance with clinical practice and marketing authorization. |
CAPUCINE MORELOT PANZINI; | 2023-07-01 |
| 291 | A Clinical Validation Study to Evaluate The Diagnostic Accuracy of A Cough-based Auxiliary Diagnosis Algorithm for Chronic Obstructive Pulmonary Disease (COPD) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Cough is one of the most common symptoms in COPD patients, and its different characteristics in amplitude, frequency and waveform can be analyzed by intelligent algorithms for the auxiliary diagnosis of COPD. The current study is to conduct external clinical validation of COPD auxiliary diagnosis algorithm and lung function prediction algorithm, and preliminatively verify the performance of the algorithm, with the ultimate goal of developing a portable and rapid COPD auxiliary diagnosis and condition assessment tool that can be used at home. |
RUIJIN HOSPITAL | 2023-07-01 |
| 292 | Precision, Pulmonary Disease Evaluation and Lung Cancer Detection Using Quantitative Low-dose CT PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this project is to validate quantitative lung structure assessment using an automated analysis software (VIDA), for application to low dose computed tomography (LDCT) acquired for lung cancer screening. Currently the software runs on standard dose CT data. In addition, it is the plan to incorporate algorithms into the software to address assessment of any identified pulmonary lesions. |
JESSICA SIEREN; | 2023-07-01 |
| 293 | Effects of Elastic Tape on Pulmonary Rehabilitation of Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the effect of the use of elastic tape in chest wall and abdomen in the physical capacity, psychosocial distress levels, quality of life and anxiety, and depression symptoms of individuals with moderate to very severe COPD undergoing pulmonary rehabilitation. |
UNIVERSITY OF SAO PAULO GENERAL HOSPITAL | 2023-07-01 |
| 294 | Acute Effect of Whole-body Electrical Stimulation in COPD Patients: A Crossover Randomized Clinical Trial Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with chronic respiratory diseases present in addition to respiratory symptoms, peripheral muscle dysfunction, which contributes to functional impairment. The aim of the study is to investigate the safety of whole-body electrical stimulation in patients with chronic obstructive pulmonary disease (COPD). Patients will perform two whole body electrostimulation protocols, with an interval of one week between them. The primary outcome will be the safety of electrical stimulation through peripheral oxygen saturation, respiratory rate, systolic blood pressure, diastolic blood pressure, heart rate, dyspnea and fatigue (Borg subjective perceived exertion scale), … |
JOCIANE SCHARDONG; | 2023-07-01 |
| 295 | Examination of Acute Effects of Different Intensity Respiratory Muscle Training on Respiratory Muscle Activations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It has been observed in the literature that respiratory muscle electromyography activations at certain threshold loads have been examined in individuals with chronic obstructive pulmonary disease. However, no study has been found in the literature examining the acute effects of respiratory muscle training given at low, medium and high threshold loads on respiratory muscle activations. With this planned study, it is aimed to examine the electromyography activations of respiratory muscles before and after respiratory muscle training and to contribute to the literature by comparing the acute effects of respiratory muscle training applied at low, … |
CEYHUN TOPCUOĞLU; | 2023-06-30 |
| 296 | A Phase III Open-Label Extension Study to Evaluate The Long-Term Safety of Astegolimab in Patients With Chronic Obstructive Pulmonary Disease PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the long-term safety and to explore the efficacy of astegolimab in participants with chronic obstructive pulmonary disease (COPD) who have completed the 52-week placebo-controlled treatment period in parent studies GB43311 or GB44332. |
HOFFMANN LA ROCHE | 2023-06-28 |
| 297 | Evaluation By Electrical Impedancemetry of The Variation of Lung Volumes Under NIV in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this physiologic research is to assess lung volumes variations under NIV in stable COPD patients to understand the impact of high-intensity ventilation following the current recommendations. The main objective is to evaluate the variation of End-expiratory lung volume (EELV) reflecting the functional residual capacity (FRC), via the End-tidal lung impedance (EELI) obtained by electrical impedance tomography during a 20 minutes NIV session. |
LEO GRASSION; | 2023-06-26 |
| 298 | The Effectiveness of Dual-task Exercises in Individuals With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the effect of dual-task performance on motor and cognitive functions and to determine the effect of dual-task exercises given together with the pulmonary rehabilitation program on cardiopulmonary and musculoskeletal parameters in COPD. The main question[s]it aims to answer are: – Is dual-task performance in individuals with COPD different from healthy individuals? – Are dual-task exercises affect cardiopulmonary and musculoskeletal parameters in individuals with COPD? Patients will be randomly divided into 2 groups (Pulmonary Rehabilitation Group, … |
MARMARA UNIVERSITY | 2023-06-26 |
| 299 | Investigation of Respiratory Muscle Activations During Stable Threshold Load and Increasing Threshold Load Endurance Tests in Individuals With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the literature, it has been observed that there is an increase in respiratory muscle activity in individuals with COPD due to the increase in respiratory workload and in response to the loads given by respiratory muscle training devices. However, no study has been found in the literature comparing the activation of respiratory muscles during constant threshold load endurance test and increasing threshold load endurance test performed with respiratory muscle training devices, which are important for respiratory muscle function evaluation. With this planned study, … |
CEYHUN TOPCUOĞLU; | 2023-06-25 |
| 300 | Medlink for Diagnosing of Diabetes Mellitus, COPD, CHF, Myasthenia Gravis and Hypertension PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: MEDLINK IS A POCKET-SIZED MEDLINK is a pocket-sized, verbally interactive, programmable medical device that allows physicians to select which medical measurements they would like to take for a specific patient. The Physiological Parameters that can be measured by MEDLINK include, but is not limited to: Electrocardiography (ECG), Blood Pressure, Heart Rate, Blood Glucose, Pulse Rate, Blood Oxygen Saturation (SPO2), Electromyography (EMG) body temperature, and Respiratory Data. MEDLINK is a pocket-sized, verbally interactive, … |
ESTHER OLAWUYI; | 2023-06-16 |
| 301 | An Investigation of Different Type Single Limb Exercise Training Effects on Functional Capacity, Arterial Stifness, Muscle Activation and Quality of Life in Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise limitation is observed in COPD. Especially, decreased exercise performance related to vascular and fatique in quadriceps muscle. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and fatigue are observed in COPD. One leg exercise training result is not enough to highlight these parameters. Three types single leg exercise intervantion will be applied. Exercise capacity, muscle strength, lung function, electromyography, lactate and quality of life will be measured. |
ELIF KOCAAGA; | 2023-06-16 |
| 302 | Impact of Smoking Cessation Duration on Postoperative Complications in Lung Cancer Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the relationship between the duration of smoking cessation before surgery and postoperative complications in lung cancer patients undergoing surgery. Lung cancer surgery patients who have recently quit smoking or are long-term nonsmokers will be evaluated to determine if the timing of smoking cessation impacts the risk of complications after surgery. By analyzing these factors, the study seeks to provide guidance on optimal smoking cessation timing to reduce postoperative risks. |
CANER İŞEVI; | 2023-06-15 |
| 303 | Measuring Lung Mechanics in Patients With Chronic Obstructive Pulmonary Disease (COPD) Using The Rapid Expiratory Occlusion Method (REOM) Handheld Portable Oscillometer: A Cross-Sectional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose the study is to determine the agreement between the information obtained about lung mechanics (lung function) from the Rapid Expiratory Occlusion Monitor (REOM) handheld portable device with that obtained by conventional oscillometry as well as by pulmonary function testing (PFT), in patients with both ‘mild’ as well as ‘very severe’ forms of chronic obstructive pulmonary disease (COPD). This study also intends to study the user experience with this handheld portable device. |
BRYAN ROSS; | 2023-06-13 |
| 304 | Efficacy and Safety of Inhaled Nitric Oxide in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease: A Prospective, Single-center Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the influence of exercise capacity and safety of iNO at doses of 10 ppm or 40 ppm for 2 hours per day after continuous treatment for one week, which is of great significance for finding safe and effective methods for treating COPD. |
THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY | 2023-06-07 |
| 305 | Phase IV, 12-week, Single Arm, Open Label Study Evaluating The Safety and Efficacy of Fixed Dose Triple Combination FF/UMEC/VI Administered Once Daily in The Morning Via A Dry Powder Inhaler in Participants With Chronic Obstructive Pulmonary Disease in India PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate safety and efficacy of FF/UMEC/VI via ELLIPTA® inhaler. ELLIPTA is a registered trademark of GlaxoSmithKline group of companies. |
GLAXOSMITHKLINE | 2023-06-06 |
| 306 | The Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized Chronic Obstructive Pulmonary Disease Patients: The COPD Readmit Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether early diagnosis of OSA and initiation of and adherence to CPAP therapy in patients hospitalized for chronic obstructive pulmonary disease reduce 30-day hospital readmission rates. |
DENNIS HWANG; | 2023-06-01 |
| 307 | A Pragmatic Real-world Multicentre Observational Research Study to Explore The Clinical and Health Economic Impact of MyCOPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: COPD is a condition which affects over 3 million people in the UK. It causes chronic symptoms including breathlessness and cough, limitations in exercise tolerance and acute exacerbations of COPD (AECOPD) which often lead to hospital admission. Current treatment for COPD includes inhaled medication and exercise programmes called Pulmonary Rehabilitation(PR) to improve exercise tolerance and resilience to AECOPD. Currently NHS respiratory services are struggling to provide support to patients with COPD, … |
MY MHEALTH | 2023-06-01 |
| 308 | Prognostic Value of The Fat-free Mass Index on A Multidimensional Scale in Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: General Objective: To compare the prognostic value of the FODE scale for COPD exacerbations, where the fat-free mass index (FFMI) will be measured instead of the body mass index (BMI) in the BODE scale. Specific objectives: to describe the nutritional status of COPD patients according by the GesEPOC and GOLD phenotypes; to compare the mortality prognostic value of FODE with BODE; to compare the exacerbations and mortality prognostic value of the BODCAT scale, which includes the CAT questionnaire instead of the six-minute walking test (6MWT), with BODE; to compare the mortality prognostic value of the FODE and FODEx scales, … |
DANIEL LÓPEZ PADILLA; | 2023-06-01 |
| 309 | Effects of Respiratory Proprioceptive Neuromuscular Facilitation (PNF) Technique on Pulmonary Function of Chronic Pulmonary Obstructive Disease (COPD) Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the impact of PNF technique combined with aerobic exercises among COPD patients in a clinical setting. Previous literature has evaluated this technique in ventilated patients but in clinical setting specifically in Pakistan, this invention therapy has not been implied in COPD patients. |
SUMAN SHERAZ; | 2023-06-01 |
| 310 | Hemodynamic Assessment of The Hand Arterial Perfusion Through The Ultrasound-Doppler Hand Acceleration Time (HAT) Technique: A Descriptive Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic upper limb ischemia syndrome is uncommon compared to lower limb ischemia, with several potential causes (e.g., arteriosclerosis, compressive syndromes, arteritis, connective tissue diseases, trauma, and thrombosis). Many patients with upper limb ischemia remain asymptomatic due to arterial collateral vascularization. Given the wide variety of potential causes for upper limb ischemia, the diagnosis may require different technical approaches. Doppler ultrasound is a noninvasive, accessible, non-radiating technique that provides direct arterial imaging, … |
BEGOÑA GONZALO VILLANUEVA; | 2023-06-01 |
| 311 | Efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome |
MAHIDOL UNIVERSITY | 2023-06-01 |
| 312 | Asymmetric (DUET) Versus Conventional Nasal High Flow Interface for Management of Hypercapnic Patients With Mild to Moderate Acute Exacerbation of COPD: A Randomized, Crossover Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the new asymmetric nasal high flow interface with the conventional high flow nasal cannula in patients with COPD exacerbation. The main questions the study aims to answer are: • Does the use of the asymmetric interface lead to: 1. A greater decrease in the patients’ carbon dioxide 2. A greater decrease in respiratory rate and less dyspnea 3. Less need for advanced oxygen therapy measures 4. Same tolerance and comfort 5. Lower heart rate and blood pressure Participants will be asked to: Wear the asymmetric and conventional cannulas for 3 hours each with a 30 minute gap in-between. Arterial blood samples and various clinical parameters will be collected throughout the study period. Researchers will compare the effect of asymmetric versus conventional cannulas to answer the aforementioned questions. |
IOANNIS PANTAZOPOULOS; | 2023-06-01 |
| 313 | Effect of Selective Manual Therapy Techniques in Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study aiming for determining the combined effect of selective manual therapy techniques in chronic obstructive pulmonary disease patients |
AMIRA SAAD MOHAMED; | 2023-06-01 |
| 314 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Dose-response Phase 2 Clinical Trial to Compare The Efficacy and Safety of Bronpass Tab. Versus Placebo in Patients With Stable COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial is a multicenter, randomized, double-blind, placebo-controlled, parallel-group dose-response phase 2 clinical trial study to evaluate the efficacy and safety of Bronpass Tab. in 96 patients with chronic obstructive pulmonary disease. |
KWANG HA YOO; | 2023-06-01 |
| 315 | Efficacy of Catheter Ablation of Frequent Asymptomatic Idiopathic Premature Ventricular Complexes in Treating Latent Left Ventricular Systolic Dysfunction As Being Assessed By Speckle Tracking of LV Global Longitudinal Strain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Throughout the past decade, there were no straightforward recommendations regarding the management of asymptomatic high-burden Premature ventricular complexes (PVCs) in structurally normal heart extending from the European Society of Cardiology (ESC) guidelines of management of ventricular arrhythmias in 2014, passing by the American Heart Association (AHA), American College of Cardiology (ACC), and Heart Rhythm Association (HRA) guidelines 2017, … |
AIN SHAMS UNIVERSITY | 2023-06-01 |
| 316 | A Randomized, Parallel Group, Phase III, Non-inferiority Study Comparing Ipratropium / Levosalbutamol Fixed Dose Combination and Ipratropium and Levosalbutamol Free Dose Combination Nebuliser Solutions in Stable Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the acute bronchodilator effect of the Ipratropium / Levosalbutamol 1.25 mg & 0.5 mg / 2.5 mL fixed dose combination nebuliser solution or Levosalbutamol 1.25 mg / 3 mL nebuliser solution and Ipratropium 500 mcg nebuliser solution in stable moderate-severe-very severe COPD patients. |
NEUTEC AR GE SAN VE TIC A Ş | 2023-06-01 |
| 317 | Outcomes in Real-life After Initation Of TreatmeNt With Trixeo (Budesonide / Glycopyrronium / Formoterol), A Non-interventional, Multi-centre, Prospective Cohort Study in Italian Routine Care Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the CHOROS ORION study is to describe patients’ clinical and self-reported outcomes of treatment with BGF in Italy through effectiveness, clinical and self-reported measures assessed pre- and post-treatment initiation, up to one year of observation period. The study will focus primarily on the change in self-perceived health status in the first 12 weeks of treatment. This will allow to assess the short-term impact of treatment, thus contributing to fill the gap of knowledge from the current available medical literature. Moreover, in order to provide also a broader view, patients will be followed up to 52 weeks, … |
ASTRAZENECA | 2023-05-31 |
| 318 | A CLINICAL STUDY OF THE MeMed BV® TEST TO DISTINGUISH BETWEEN BACTERIAL AND VIRAL INFECTIONS AND LIMIT GUT COLONIZATION BY MULTIDRUG RESISTANT MICROORGANISMS PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The fast increase of Multidrug-resistant microorganisms (MDRO) due to the high amount of antimicrobials being poorly used may be limited by better regulating antimicrobial usage globally. The goal of this observational study is the performance of the MeMed BV® test in the MeMed Key® device at the emergency department to a) support the differential diagnosis between bacterial and viral infections of the respiratory tract and b) provide evidence of how the use of this test may limit gut colonization by MDRO. |
HELLENIC INSTITUTE FOR THE STUDY OF SEPSIS | 2023-05-29 |
| 319 | Evaluation of 3D Magnetic Resonance Spirometry: Comparison with Spirometry in Healthy Subjects and Patients with Respiratory Pathologies (asthma, COPD, Bilateral Lung Transplant) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Spirometry is now the gold standard technique for assessing lung function in humans. From the shape of a flow-volume curve measured while the patient, trained by the practitioner, performs forced breaths, the forced vital capacity (FVC) and the forced expiratory volume in one second (FEV1) can be deduced and the pulmonologist is able to detect and characterize respiratory diseases as well as to evaluate current treatments. This technique is non-invasive and simple. It is widely available, robust, reproducible and sensitive to intervention. However, it requires proactive cooperation from the patient and only measures global pulmonary ventilation, … |
VINCENT LEBON; | 2023-05-26 |
| 320 | Efficacy and Safety of Beta-glucan Supplement in Chronic Obstructive Pulmonary Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objectives of this study are to evaluate Efficacy and safety of beta-glucan supplement in chronic obstructive pulmonary disease patients. |
PORNANONG ARAMWIT; | 2023-05-25 |
| 321 | Dongzong Cardiovascular Bio-imaging Registry Study PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The DAILY project is a large-scale, multicenter, prospective initiative designed to establish a comprehensive bio-imaging database that integrates multidimensional data, including living environments, psychosocial and cognitive assessments, advanced lung and cardiovascular imaging, multi-omics profiles, clinical medication and surgical records, and health outcomes. Leveraging this extensive, multiscale dataset, the project aims to elucidate the intricate interplay between genetic biology and environmental factors in driving downstream biological alterations, thereby shaping lung and cardiovascular structural and functional phenotypes, and ultimately influencing the onset and progression of cardiovascular diseases (CVD). Through a systematic exploration and understanding of this complex network, … |
ZHANG LONGJIANG; | 2023-05-24 |
| 322 | Effect of L-menthol on Breathlessness and Exercise Capacity in Chronic Obstructive Pulmonary Disease: A Randomized PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the effect of L-menthol on breathlessness in patients with chronic obstructive pulmonary disease (COPD). |
ZAINAB AHMADI; | 2023-05-24 |
| 323 | Comparative Effects of Inspiratory Muscle Training Vs Expiratory Muscle Training Along With Aerobic Interval Training on Functional Performance and Fatigue Level in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is the 3rd leading cause of mortality and 7th leading cause of ill-health worldwide. It is characterized by persistent and progressive air flow resistance with expiratory flow more compromised as compared to inspiratory flow leading to CO2 retention and prominent hyperinflation of lungs. The overall effects of COPD on the patient’s entire body include pulmonary, followed by extra-pulmonary manifestations in which musculoskeletal derangements are more pronounced and interfere with daily activities, … |
HAFIZA MURIAM GHANI; | 2023-05-23 |
| 324 | The Effect of Acupressure on The Management of Dyspnea in Palliative Care Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnea can develop at any stage of the disease, but it is more common in the last period of life. Complementary and integrative methods used for dyspnea symptoms include acupuncture, acupressure, visualization techniques, herbal treatments, nutritional supplements, stress management, relaxation techniques, exercise, breathing training and psychotherapy, etc. There are studies in the literature showing that acupuncture and acupressure are effective in controlling dyspnea symptoms in various disease groups. Acupressure is an integrated method of applying physical pressure to acupuncture points on the body surface with hands, elbows or various tools. With good counseling, patients can apply this method, … |
DİLEK YILDIRIM; | 2023-05-22 |
| 325 | Non-contact Proactive Remote Monitoring to Facilitate Early Detection of Exacerbations in Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to determine if a COPD exacerbation can be detected early in its onset. The main questions it aims to answer are: * Can an exacerbation be detected before the person recognizes they are unwell? * What are the biological signals which provide the best indication of decompensation? * How does this indication of decompensation compare to a daily CAT? Participants will be asked to place a device, DistaSense, on top of their mattress and then sleep as normal. In addition, they will be asked to complete a daily CAT. |
JOHN HURST; | 2023-05-15 |
| 326 | Effects of BBT Versus Diaphragmatic Breathing on Exercise Capacity and Quality of Life in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Group A will be treated with manual chest physical therapy and Buteyko breathing technique Group-B will be treated with manual chest physical therapy and Diaphragmatic breathing technique. Patients will perform the technique 5 times a weeks for 8weeks and treatment evaluation will be done after 8 weeks |
SIDRA FAISAL; | 2023-05-15 |
| 327 | Comparative Effects of BBT and Active Cycle of Breathing Technique on Dyspnea and Quality of Life in COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Comparative effects of Butyeko breathing technique and Active Cycle of Breathing technique on dyspnea and quality of life in patients with chronic obstructive pulmonary disease |
SIDRA FAISAL; | 2023-05-15 |
| 328 | Preliminary Monocentric Study for The Validation of The Circuit of Examinations and Analyzes of Samples in Perspective of Large-scale Application for Better Classification of Airway Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: ADs (airway diseases) are a group of progressive diseases that lead to a decline of lung function, accelerated by recurrent exacerbations, which can lead to death. ADs include a number of different conditions including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis and bronchiolitis frequently related to immune difciency or hematopoietic stem cell transplantations (HSCT), … |
HOPITAL FOCH | 2023-05-15 |
| 329 | Randomized Controlled Study of Programmed Weaning From Noninvasive Mechanical Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose of research:to explore a reasonable programmed withdrawal process of noninvasive ventilation and thereby reduce the duration of noninvasive mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. |
QINGTAO ZHOU; | 2023-05-12 |
| 330 | Best End-Expiratory and Driving-Pressure for Individualized Flow Controlled Ventilation in Patients With COPD – An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with chronic obstructive pulmonary disease (COPD) have a significantly increased risk of postoperative pulmonary complications (PPC). Protective ventilation of the lungs could reduce the rate of PPC in patients with COPD. It has been suggested that flow controlled ventilation (FCV) may be less invasive and more protective to the lungs than conventional ventilation in patients with COPD. The primary aim of this study is to determine a optimal individual ventilation setting for FCV in ten participants with COPD. |
ANDRÉ DANKERT; | 2023-05-08 |
| 331 | Real-world Evidence Feasibility Trial, in Both Community and Hospital-based Settings, for A Technology-enabled Hybrid Service Delivery Model for Pulmonary Rehabilitation: Assessing Patient Uptake and Adherence, and Impact on Patient Outcomes and Service Capacity PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary rehabilitation is an exercise and education programme that helps improve breathlessness and quality of life for people living with lung and breathing problems. It improves exercise levels and breathlessness and is a recommended treatment for people with lung diseases and symptoms. Standard pulmonary rehabilitation programmes involve individuals attending group classes at hospitals or community centres, twice a week for 8 weeks. These classes are supervised by physiotherapists. At the moment, … |
ANGLIA RUSKIN UNIVERSITY | 2023-05-04 |
| 332 | Assessment Of Different Scores In Predicting Outcome In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease Patients In Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: evaluate the value of different scores in predicting hospital mortality and Need for MV In patients presented to ED with AECOPD. |
MOHAMMED MOSTAFA SALEH HUSSEIN; | 2023-05-03 |
| 333 | Withings Study to Analyze The Accuracy of Pulse Wave Velocity Measurement With Bathroom Scales PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the diagnostic performance of Withings bathroom scales WBS08 and WBS12 to measure PWV (Pulse Wave Velocity). |
PIERRE BOUTOUYRIE; | 2023-05-02 |
| 334 | An Observational Cohort Study of Inhaler Adherence and Blood Eosinophil Count in Exacerbations of Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study examining inhaler adherence and subsequent changes in blood eosinophil count in exacerbations of Chronic obstructive pulmonary disease (COPD) population. The study will run for 6 months as an observation period. Passive inhaler adherence monitoring will be done electronically via inhaler sensors connected to mobile Apps, and collecting symptoms questionnaires, diary of exacerbation events and trial visits predominantly in remote fashion. It will explore the feasibility of digital platform in clinical practice to collect the adherence data along with exacerbation events. |
NEIL GREENING; | 2023-05-01 |
| 335 | Predictors Of Chronic Thromboembolic Pulmonary Hypertension Following Acute Pulmonary Embolism PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Identify risk factors for developing chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Determine echocardiographic predictors of chronic thromboembolic pulmonary hypertension. Determine the radiological predictors of chronic thromboembolic pulmonary hypertension in CT pulmonary angiography. |
ASMAA GAMAL ABD ELHAMIED; | 2023-05-01 |
| 336 | The Effect of Inhaled Corticosteroids (ICS) Adjunct Therapy on Pulmonary Vascular Endothelial Function in Chronic Obstructive Pulmonary Disease (COPD): Comparison of Two Standard Treatments (NCT05607719 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study objective is to determine whether an ICS added for 4 weeks to a baseline treatment with a Long-Acting Beta-adrenergic Agonist (LABA) and Long-Acting Muscarinic Antagonist (LAMA) combination improves pulmonary vascular endothelial function as assessed by the vasodilator response to inhaled albuterol (endothelium-dependent vasodilation) in stable COPD patients treated with a LABA/LAMA without an ICS for at least one month. |
ADAM WANNER; | 2023-05-01 |
| 337 | Balance Training: Its Effect on Pulmonary Rehabilitation of Elderly Subjects With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study will be to verify whether the addition of an exercise program aimed to improve balance can reduce the risk of falling in subjects with COPD over 80 years of age compared to the standard rehabilitation program. Patients will be randomly assigned in two groups (intervention and control). The pulmonary rehabilitation (PR) program is organized in accordance with current guidelines. |
ELISABETTA ZAMPOGNA; | 2023-05-01 |
| 338 | Comparing The Acute Effects of Tiotropium Handihaler With Tiotropium Respimat on The Ventilation Distribution in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if tiotropium Respimat will result in better ventilation distribution of the lung in COPD participants quantified by hyperpolarized XeMRI. This study is designed to simulate the real-life clinical setting where patients receive one-time instruction on the inhaler use. |
YUH CHIN T HUANG; | 2023-05-01 |
| 339 | A Randomized, Double-blind, Placebo-controlled, Phase 1 Study of AER-01 (Solution for Inhalation, Delivered Via Nebulizer): As A First-In-Human Single Ascending Dose in Healthy Volunteers (Part A), and A 7-day Multiple Ascending Dose in Healthy Volunteers and Subjects With Chronic Obstructive Pulmonary Disease (COPD) and Moderate Airflow Limitation (Part B) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a first-in-human, randomized, double-blind, placebo-controlled, Phase 1 study of AER-01 (solution for inhalation, delivered via nebulizer) to assess the safety, tolerability and PK of AER-01. The study will be conducted in 2 parts: a single ascending dose (SAD) part in HVs (Part A) and a 7-day multiple ascending dose (MAD) part in HVs and subjects with COPD and moderate airflow limitation (Part B). |
EMIR REDZEPAGIC; | 2023-05-01 |
| 340 | Assessment of Salbutamol Effect on Arterial Oxygenation in COPD Patients During One-lung Ventilation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One-lung ventilation (OLV) is essential part of anesthesia during thoracic procedures. However, OLV induces a drastic increase of intrapulmonary shunt due to maintained pulmonary perfusion through the nonventilated lung, which may result in severe hypoxemia. Although the protective mechanisms of hypoxic pulmonary vasoconstriction favorably modulate pulmonary perfusion to the ventilated lung, the effect is attenuated in patients with history of chronic obstructive pulmonary disease (COPD), which alters compliance of the pulmonary artery. Salbutamol is a selective short-acting beta2-agonist and when inhaled during OLV, … |
YOUNG JUN OH; | 2023-04-25 |
| 341 | The Effect of Disease Severity and Respiratory Functions on Muscle Oxygenation in Stable COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to examine the peripheral muscle oxygenation of patients with Chronic Obstructive Pulmonary Disease at rest, during submaximal exercise and recovery, and to examine the effects of disease severity and respiratory functions on peripheral muscle oxygenations. In this study, the effect of disease severity and respiratory problems on peripheral muscle metabolism of patients with COPD will be explained. |
GULHAN YILMAZ GOKMEN; | 2023-04-24 |
| 342 | Feasibility of Pulmonary Rehabilitation Through Tele Rehabilitation Versus Traditional Center Based Pulmonary Rehabilitation for COPD in Pakistan PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the feasibility of Tele-rehabilitation vs traditional center-based pulmonary rehabilitation for people with chronic obstructive pulmonary disease |
MUHAMMAD IQBAL TARIQ; | 2023-04-20 |
| 343 | A Randomized, Parallel-group, Open, Two-period, Comparative Non-inferiority Study of Eurofarma’s Formoterol/budesonide Vs Alenia in The Treatment of Moderate to Severe Persistent Asthma with and Without Chronic Obstructive Pulmonary COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A phase III study, multicenter, randomized, parallel, open, two-period, comparative non-inferiority of Eurofarma versus Alenia® in the treatment of moderate to severe persistent asthma with and without obstructive pulmonary disease (COPD). ⚠️study will only be conducted in research centers in Brazil (please do not send e-mail if your center is outside brazil). |
EUROFARMA LABORATORIOS S A | 2023-04-19 |
| 344 | The 5 Repetitions Sit-to-stand Test, Carried Out Remotely Via Videoconference, in Patients With COPD: Is There A Learning Effect? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical study is to determine if a learning effect exists when the 5STS is assessed remotely via videoconference in patients with COPD. |
NICOLAS OLIVER; | 2023-04-18 |
| 345 | A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method） PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate diagnostic performance of N-terminal Brain natriuretic Peptide (NT-proBNP) in acute heart failure among Chinese population. Further, it sought to explore the optimal cut-off point fitting Chinese patients. |
BECKMAN COULTER | 2023-04-10 |
| 346 | Evaluation of Skeletal Muscle Function in Patients With Chronic Obstructive Pulmonary Disease Before and After Lung Rehabilitation Training Using Ultrasonic Elastography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of observational study is to evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography. Participants will undergo pulmonary rehabilitation. |
GANG HOU; | 2023-04-07 |
| 347 | The Usage of Spacers and The Relationship With Symptoms Severity in Chronic Obstructive Pulmonary Disease Elderly Patients: A Correlational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the usage of spacers and their relationship with symptom severity in chronic obstructive pulmonary disease elderly patients. Patients with chronic obstructive pulmonary disease aged 65 years or over at thoracic medicine outpatient clinics were recruited in this study. Research participants were interviewed using structured questionnaires, including demographic characteristics information, clinical characteristics information, and the chronic obstructive pulmonary disease assessment test. |
AI-LING CHANG; | 2023-04-06 |
| 348 | Remote Exercise-based Pulmonary Rehabilitation Telemedicine in Chronic Respiratory Disease: An Observational Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary rehabilitation is a program that helps people with lung disease improve their function. It uses exercise, education, and self-management strategies to improve physical ability and quality of life. Because some people are unable to visit West Park Healthcare Centre, we established a remote supervised pulmonary rehabilitation program that patients can access via an electronic device (computer, … |
ROGER GOLDSTEIN; | 2023-04-06 |
| 349 | Outcome Of Pulmonary Rehabilitation For Severe Chronic Obstructive Lung Disease Patients Undergoing Neuromuscular Electrical Stimulation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Patients with COPD often experience skeletal muscle dysfunction. For those who are unable or unwilling to undertake physical training, neuromuscular electrical stimulation (NMES) may provide an alternative method of exercise training. Objective: To investigate the effects of adding neuromuscular electrical stimulation of quadriceps and calf muscles to chest physiotherapy, compared to chest physiotherapy alone, on muscles strength (quadriceps and calf), femoral blood flow physical and pulmonary function in severe COPD Patients. |
AHMED SAMIR ABDELKHALIK YOUSSEF; | 2023-04-02 |
| 350 | Digital Innovation With Remote Management and Predictive Modelling to Integrate COPD Care With Artificial Intelligence-based Insights: An Acceptability, Feasibility and Safety Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: DYNAMIC AI is an MHRA-regulated medical device trial that will examine the feasibility of using AI predictive models within COPD multi-disciplinary team meetings, to allow clinicians to prioritise and optimise COPD management. |
NHS GREATER GLASGOW AND CLYDE | 2023-04-01 |
| 351 | Exploring Novel Biomarkers for Emphysema Detection: The ENBED Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate whether voice or capnometry, alone or in combination with other (non invasive) biomarkers can be used to detect emphysema on chest CT-scan in people with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is: • Can a machine-learning based algorithm be developed that can classify the extent of emphysema on chest CT scan from patients with COPD, based on voice and/or capnometry. Participants will: – perform different voice-related tasks – perform capnometry twice (before/after exercise) – perform a light exercise task between tasks ( 5-sit-to-stand test) – … |
SAMI SIMONS; | 2023-04-01 |
| 352 | Exploring Clinical Predictors of COPD Exacerbation in A Community Cohort PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of our study is to assess the feasibility and benefits of the implementation of an interactive telemonitoring system for earlier detection of COPD exacerbations in a community cohort preventing further deterioration requiring hospital admissions. |
MARIA JOAO BARBOSA; | 2023-04-01 |
| 353 | A40 EFL Registry: A Multicenter Prospective Study to Determine The Role of Expiratory Flow Limitation (EFL) in Patients With Chronic Obstructive Pulmonary Disease (COPD) Receiving Home Mechanical Ventilation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective observational multicenter registry study will include adults greater than 40 years old, diagnosed with chronic obstructive pulmonary disease, requiring home noninvasive ventilation as part of standard medical care. For the purposes of this study, chronic obstructive pulmonary disease is defined as chronic respiratory failure consisting of historical spirometry vales (FEV1 <60% predicted and FEV1/VC < 0.7) and chronic increased daytime carbon dioxide levels greater than 6.0 kPa or 45 mmHg. In addition, ... |
MICHAEL POLKEY; | 2023-04-01 |
| 354 | Prediction of COPD Chest CT Severity Using Electrical Impedance Tomography By Machine Learning Methods PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to predict the CT visual score of emphysema with EIT-based parameters, in order to provide a non-invasive and convenient method for the evaluation of lung structure and physiological and pathological progression of COPD. |
WANG KAIFEI; | 2023-04-01 |
| 355 | The Effect of Face Hand Fan Application on Dyspnea and Quality of Life in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diagnosing and managing dyspnea in patients with COPD is very important. Although pharmacological and non-pharmacological methods are used in the management of dyspnea, it is recommended that pharmacological methods be supported by non-pharmacological methods. Hand fan application, which is one of the non-pharmacological methods used in dyspnea management, provides an increase in self-efficacy in patients in addition to the stimulation of cold air flow to the trigeminal nerve branches, mucosa and skin. Although there are studies reporting that applying cold air to the face with a hand fan is effective in reducing the severity of dyspnea in different patient groups, … |
NECMIYE ÇÖMLEKÇİ; | 2023-04-01 |
| 356 | Effectiveness and Impact of Counseling Enhanced Using Electronic Cigarettes for Harm Reduction in People With Serious Mental Illness PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this open-label, randomized controlled trial study, participants who smoke combustible cigarettes (CC) and are diagnosed with Serious Mental Illness (SMI) will be randomized in two arms to receive harm-reduction counseling and Ecological Momentary Intervention text messaging (EMI) along with either e-cigarettes (EC) or nicotine replacement therapy (NRT) such as patch, lozenges and gums to compare the efficacy in CC smoking reduction. |
OMAR EL-SHAHAWY; | 2023-04-01 |
| 357 | Comparison of Multiple Methods of Exercise Training for Accessing Maximal Oxygen Consumption, Skeletal Muscle Oxygen Saturation, and Cardiopulmonary Outcomes in Patients With Chronic Respiratory Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study aims to investigate the effect of different exercise training in patients with chronic respiratory disease. |
KE-YUN CHAO; | 2023-04-01 |
| 358 | Satisfaction Survey on The Tolerability of Surgical Masks for Protection Against The Spread of SARS-CoV2 in Patients With Chronic Respiratory Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is conducted in the context of the COVID-19 pandemic in general, and more specifically in the context of the evaluation of the use of protective masks as a barrier to the spread of the virus. The wearing of masks is one of the recommended barrier measures to limit the spread of the SARS-CoV-2 virus responsible for COVID-19. It is recommended in all circumstances, and mandatory in some. Regardless of the type of mask used (noting that the so-called surgical masks are by far the most common), … |
THOMAS SIMILOWSKI; | 2023-04-01 |
| 359 | Interest of Performing Two 6-minute Walk Tests at The End of A Pulmonary Rehabilitation Program, in COPD Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In pulmonary rehabilitation, the 6-Minute Walk Test (6MWT) is essential to assess the effects of the program on patients’ health. Current guidelines don’t recommend to perform two 6MWT at the end of pulmonary rehabilitation. However, a more recent study shows that two 6MWT should be performed at the end of the program to accurately and reliably assess patients’ capacities. The aim of this study is to compare the results of two tests performed at the end of the program by COPD patients to find out whether there is a benefit of performing two 6MWT at the end of pulmonary rehabilitation. |
MARC BEAUMONT; | 2023-03-24 |
| 360 | Synergistic Assessment of Ultrasound Data and Respiratory PhysiOlogical Signals in LuNg Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The use of lung ultrasound is instrumental in the evaluation of many chest pathologies and its ability to detect pleuro-pulmonary pathology is widely accepted. However, the use of ultrasound to explore the state of the peripheral lung parenchyma, when the organ is still aerated, is a relatively new application. Horizontal and vertical artifacts are separate and distinct artifacts that can be seen during ultrasound examination of the lungs. While the practical role of lung ultrasound artifacts is accepted to detect and monitor many conditions, further research is needed for the physical interpretation of ultrasound artifacts. These artifacts are diagnostic signs, … |
RICCARDO INCHINGOLO; | 2023-03-22 |
| 361 | The Association Between Obstructive Sleep Apnea Severity and Red Blood Cells Indices PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of obstructive events (apnea and hypopnea) and intermittent hypoxia, which in turn contributes to the systemic inflammation that underlies this disease and its consequences (Ryan et al 2009, Gileles-Hillel et al 2014). This systemic inflammation leads to endothelial dysfunction, which contributes to the pathogenesis of cardiovascular complications in OSAS, in addition to the exposure to risk factors, such as male gender, older age, obesity, … |
TAMER AWAD; | 2023-03-20 |
| 362 | A Phase 2a Randomized, Placebo-Controlled Clinical Study to Evaluate The Efficacy and Safety of MK-5475 in Adults With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Researchers are looking for ways to treat pulmonary hypertension (PH) caused by chronic obstructive pulmonary disease (COPD). The goal of the study is to learn if people who take MK-5475 can walk farther in 6 minutes at Week 24 compared to people who take placebo. |
MERCK SHARP & DOHME | 2023-03-16 |
| 363 | Study on The Mechanism of Inhaled Nitric Oxide in The Treatment of Patients With Chronic Obstructive Pulmonary Disease (COPD) Complicated With Pulmonary Hypertension PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is a lack of effective treatments for chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension. Previous studies have found that inhaled nitric oxide (iNO) can reduce pulmonary artery pressure and improve exercise capacity in COPD with pulmonary hypertension patients. However, the specific mechanism is unclear. The study aims to evaluate pulmonary ventilation/perfusion, pulmonary artery pressure, oxygenation, symptoms and quality of life in COPD with pulmonary hypertension patients after short-term treatment with iNO. Observing a series of pathophysiological changes caused by the treatment of pulmonary hypertension with iNO in COPD, … |
TING YANG; | 2023-03-14 |
| 364 | The Effect of Respiratory Exercise Applied to COPD Patients With Virtual Reality Glasses on Dyspnea, Anxiety and Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It was planned to examine the effects of breathing exercises applied with virtual reality glasses on dyspnea, anxiety and quality of life in COPD patients. The study was planned to be conducted in a single-blind pre-test post-test parallel group randomized controlled experimental design. Hypotheses created for the research; … |
ARDAHAN UNIVERSITY | 2023-03-13 |
| 365 | Comparison of Dynamic Respiratory Muscle Strength and Endurance, Physical Activity Level and Physical Fitness in Asthmatic Children and Their Healthy Peers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Peak inspiratory flow (PIF) may be due to respiratory muscle strength, especially in those with severe airflow obstruction. PIF appears to be lower in children and adolescents with asthma than in non-asthmatics and correlates positively with age, height, weight, and respiratory muscle strength. Although physical activity and fitness are also believed to be important in lung health, the relationship between lung function and physical fitness is unclear. It measures dynamic lung volumes, s-index and PIF and provides information on dynamic lung function in children and adolescents. In this study, … |
ŞEYMA NUR ÖNAL; | 2023-03-13 |
| 366 | A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate The Efficacy and Safety of Ensifentrine Over 24 Weeks in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, double-blind, placebo-controlled, parallel-group clinical study, which aims to evaluate the efficacy, safety, and PK characteristics of Ensifentrine 3 mg twice daily (BID) for 24 weeks treatment of moderate to severe COPD. |
NUANCE PHARMA SHANGHAI | 2023-03-10 |
| 367 | Comparison of 2 Different Methods in Infraclavicular Block PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background :The investigators wanted to see if dexamethasone, which is routinely used as an adjuvant tool by different anesthesiologists in the orthopedics operating room, can really start the effect of other local anesthetics early and prolong the duration of action during infraclavicular block, and giving less additional analgesics after surgery. Aims:The investigators plan to determine whether this outcome of , dexamethasone which is routinely used as an adjuvant tool to prolong postoperative analgesia. Methods :60 participants will be included in the study. It includes participants the age of 18, … |
ESMA M SIMSEK; | 2023-03-10 |
| 368 | Added Diagnostic Value of Point of Care Ultrasound in Acute Dyspnea: A Prospective Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnea is a common diagnostic challenge in the Emergency Department (ED). Delay in diagnosis will increase time to correct treatment and could impact outcome. Previous studies have shown excellent diagnostic performance of point of care ultrasound (POCUS) to detect and differentiate between several important diagnosis (e.g heart failure and pneumonia) in patients with dyspnea. However, … |
JAKOB LUNDAGER FORBERG; | 2023-03-09 |
| 369 | Investigation of Peripheral Muscle Oxygenation At Rest and Movement in Hospitalized Patients in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Comparison with Stable Period PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of our study is to examine the Peripheral Muscle Oxygenations at rest and in motion on the 2nd day of hospitalized patients and before discharge in Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease and to compare the results in the hospital periods by repeating the tests in the stable periods of the patients 1 month after discharge. |
GULHAN YILMAZ GOKMEN; | 2023-03-08 |
| 370 | Effects of Post-isometric Relaxation Technique on Chest Expansion and Pulmonary Function Tests in Smokers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study was to investigate the immediate effects of PIR technique on chest expansion and pulmonary functions in cigarette smokers.This quasi-experimental pre-test post-test study will be conducted. Participants of interest would be approached and explained about the research. Informed written consent will be taken. Recruited participants will receive PIR technique on assessory respiratory muscles and chest expansion and pulmonary function tests will be obtained before and after the treatment. Data collection tools for this study are spirometer and measuring tape. |
FOUNDATION UNIVERSITY ISLAMABAD | 2023-03-07 |
| 371 | A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Extension Study to Evaluate The Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease (COPD) With A History of Exacerbations (PROSPERO) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Subjects who completed either OBERON or TITANIA will be offered the opportunity to consent for this Multicentre, Double-blind, Randomised, Placebo controlled, Parallel Group, Phase 3, extension study to evaluate the safety and efficacy of Tozorakimab in adult participants with symptomatic COPD. |
ASTRAZENECA | 2023-03-06 |
| 372 | The Effects of Combining Manual Soft Tissue Release and Physical Exercise Training on Lung Function(LF), Exercise Capacity(EC), and Cardiac Autonomic Function(CAF) in Moderate to Severe COPD: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The potential effects of combining manual soft tissue release and physical exercise training on lung function, exercise capacity, and cardiac autonomic function in patients with moderate and severe chronic obstructive pulmonary disease were investigated. |
KUN-LING TSAI; | 2023-03-02 |
| 373 | China Elderly Comorbidity Medical Database PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this observational cohort study is to provide comprehensive evaluation and early warning for elderly patients with chronic diseases. The main question it aims to answer is: How to explore effective evaluation methods for diseases in elderly patients based on the coexistence of multiple diseases and high individual heterogeneity? How to explore the key indicators and influencing factors of adverse events in elderly patients.. Participants will be followed up at 1, 3, 6, 9, and 12 months to obtain adverse event information. |
HONGWEI LI; | 2023-03-01 |
| 374 | The Addition of Inhaled FUROsemide to Standard of Care in COPD Exacerbation: A Randomized Double Blinded Control Trial (FUROSCOPE Trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized controlled trial is to determine the effect of adding inhaled furosemide to the known treatment of patient with Chronic obstructive pulmonary disease (COPD) exacerbation. It primarily aims at studying its effect on: 1. Relief of dyspnea sensation 2. Length of hospital stay Participants will be receiving the standard therapy of COPD exacerbation plus either inhaled furosemide or inhaled saline over 3 days. They will be asked to: – Perform spirometry – Fill in dyspnea score – Do arterial blood gases (ABGs) |
SALAH ZEINEDDINE; | 2023-03-01 |
| 375 | Evaluation of The Use of A Remote Monitoring and Follow-up Option for Patients With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the ability of the Bora Care remote monitoring solution to detect early acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD). |
NICOLAS ROCHE; | 2023-03-01 |
| 376 | Measure Airway Compliance By Endobronchial Optical Coherence Tomography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Optical Coherence Tomography （OCT）is a novel, non-invasive, high resolution special optical imaging techniques. In airway, Measure airway area and airway wall thickness is the most usage of Endobronchial Optical Coherence Tomography (EB-OCT）. Recently, the new protocol of EB-OCT is used to measure airway compliance, We will establish a new methodology of EB-OCT for measuring airway compliance, which will provide a new means to study respiratory diseases. |
XU HANG; | 2023-03-01 |
| 377 | Ultrasound of The Diaphragm As Physiological Biomarker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be conducted as a single-center, prospective cohort study. The primary objective of this study is to investigate the responsiveness of sonographic parameters of diaphragm to detect change in Borg score for dyspnea during hospitalisation for AECOPD without respiratory acidosis. |
WYTZE DE BOER; | 2023-03-01 |
| 378 | Evaluation of High Velocity Nasal Insufflation in Management of Respiratory Failure in Patients With Overlap Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: High velocity nasal insufflation (HVNI), a form of HFNC that utilizes a small bore nasal cannula to generate higher velocities of gas delivery than HFNC which uses large bore cannula, has the ability to accomplish complete purge of extra thoracic dead space at flow rates of 35 litres/min and may be able to provide ventilatory support in patients with respiratory failure in addition to oxygenation support in patients with overlap syndrome. This study aims to evaluate the effectiveness of HVNI compared to NIMV in management of respiratory failure in patients with obesity hypoventilation syndrome and overlap syndrome. |
ABANOUB HANY SADEK FARAG; | 2023-03-01 |
| 379 | Kronik Obstrüktif Akciğer Hastalığında Yürüyüş Sırasında Yürüyüşün Zaman Mesafe Karakteristikleri Ve Kol Salınımlarının İncelenmesi PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The former aim of this study is to determine whether the arm swings change in patients with Chronic Obstructive Pulmonary Disease (COPD) according to healthy subjects. The latter purposes to investigate the correlation between balance parameters and arm swing, how to change arm swing according to severity of the disease, and to determine the relationship between balance and the severity of disease, the relationship of posture both arm swing and severity of disease in patients with COPD. In accordance with this purposes, … |
AYNUR DEMIREL; | 2023-03-01 |
| 380 | A Clinical Evaluation of The RheOx Bronchial Rheoplasty System for The Treatment of The Symptoms of Chronic Bronchitis in Chinese Adult Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test in the Symptoms of Chronic Bronchitis in Chinese Adult Patients with COPD. Participants will be assigned to two sessions of treatments with RheOx – Treatment 1 is scheduled at right lung at the first treatment. – And then approximately one month later, treatment 2 is delivered to left lung at the second treatment. |
WANG GUANGFA; | 2023-03-01 |
| 381 | Mobile Application for Monitoring Patients With Home Oxygen. A Protocol of A Randomized and Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The use of mobile technology has become part of the reality capable of changing the health services’ paradigm. As a proof of that, nowadays, technology is seemed as a key tool in processes such as: data collection, epidemiological surveillance, health promotion, and disease prevention. Therefore, … |
ANISBED NARANJO ROJAS; | 2023-03-01 |
| 382 | Research of Endobronchial Optical Coherence Tomography in Pre-stage of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The pre-stage of Chronic Obstructive Pulmonary Disease (Pre-COPD) is challenging to diagnose. However, identifying Pre-COPD is a crucial step in the prevention and management of COPD. Endobronchial optical coherence tomography showed the value of diagnosis in Pre-COPD and COPD in previous researchs. |
GUANGHONG ZHOU; | 2023-03-01 |
| 383 | Effect of Intravenous Aminophylline on Hemodynamics and Recovery of Patients Undergoing Functional Endoscopic Sinus Surgery Under Dexmedetomidine Hypotensive Anesthesia: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to evaluate the effect of intravenous aminophylline on hemodynamics and recovery of patients receiving dexmedetomidine infusion during functional endoscopic sinus surgery. |
OSAMA REHAB; | 2023-02-25 |
| 384 | Improving Participation in Pulmonary Rehabilitation Through Peer Support and Storytelling PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) affects approximately 16 million Americans and is characterized by recurrent exacerbations that lead to 1.5 million Emergency Department visits and 700,000 hospitalizations annually. Pulmonary rehabilitation (PR) is a structured program of exercise and self-management support that has been proven to relieve shortness of breath and increase quality of life when initiated after an exacerbation, but unfortunately, few eligible patients participate. This project will compare the effectiveness of two novel strategies – one involving video narratives of other patients telling their story of how they overcame challenges and completed PR, … |
PETER LINDENAUER; | 2023-02-24 |
| 385 | Relationship Between Nutritional State and Respiratory Muscle Weakness in Adult Patients With Bronchietasis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To establish a relationship between malnutrion and respiratory muscle dysfunction in patients with bronchectasis |
ABDELRAHMAN GALAL SALIH; | 2023-02-23 |
| 386 | Multi-omics Analyses of Airway Host-microbiome Interaction in Chronic Obstructive Pulmonary Disease and Bronchiectasis Identify Potential Therapeutic Interventions PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) and bronchiectasis are common chronic respiratory diseases in China. COPD is characterized by irreversible lung function decline due to airway inflammation, emphysema and alveolar destruction. Bronchiectasis is characterized by permanent bronchiectasis, its main clinical symptoms are cough, dyspnea, hemoptysis and recurrent respiratory tract infections. The incidence and prevalence of bronchiectasis have assumed continuously grows in global. Airway microbiota, whose alterations play an important role in the occurrence and development of bronchiectasis, form a complex ecosystem interacted with host cells and various biotic and abiotic factors in the microenvironment. Additionally, … |
RUIJIN HOSPITAL | 2023-02-20 |
| 387 | Utility of Remote Lung Auscultation in Transitions of Care After Pulmonary Exacerbations of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Listening to breath sounds with the stethoscope/auscultation is used by pulmonary physicians in conjunction with pulmonary function, signs and symptoms, oxygen saturation and diagnostic testing to admit, follow and discharge patients from hospital. Of these, only auscultation routinely ceases upon discharge from Hospital. Healthcare utilization statistics have shown that for more than a decade, … |
SADIA BENZAQUEN; | 2023-02-20 |
| 388 | Characterizing The Recovery Phase of Acute Exacerbations of COPD Using Wearable Remote Monitoring Technology PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose the study is to successfully characterize the recovery phase of acute exacerbations of COPD in the outpatient setting using remotely captured physiologic data from wearable devices, to compare this with patient self-reported symptom data, to determine which physiologic variable(s) best correspond with AECOPD recovery, and to further document the feasibility, data quantity, data quality, and COPD outpatient usability experience with wearable devices. |
BRYAN ROSS; | 2023-02-16 |
| 389 | The Influence of Mitochondrial Derived Reactive Oxygen Species on Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease Related Papers Related Patents Related Grants Related Experts View Highlight: Cardiovascular health is a critical problem in patients with chronic obstructive pulmonary disease (COPD). Existing literature suggests oxidative stress from the mitochondria c driving some of the poor health outcomes in COPD. MitoQ is a mitochondrial-targeted antioxidant that has shown promise in improving cardiovascular outcomes in similar populations. Thus the purpose of this study is to test if MitoQ can improve cardiovascular health in COPD. |
PAULA RODRIGUEZ-MIGUELEZ; | 2023-02-16 |
| 390 | Comparison of The Efficacy of CRP, Procalcitonin and Pro-BNP As Diagnostic and Prognostic Markers in AECOPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) are one of the chief causes for admission to Emergency Department. AECOPD is a significant cause for mortality and morbidity worldwide. Emergency Medicine Physicians frequently manage these patients. Predicting the severity and possible prognosis of AECOPD is an important task for Emergency Medicine Physicians as treatment options and aggressiveness may depend on these predictions. In our study we aimed to compare different biomarkers such as Procalcitonin, … |
SERKAN DOĞAN; | 2023-02-15 |
| 391 | Clinical Study of The Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19 Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to evaluate the safety and effectiveness of umbilical cord mesenchymal stem cell (UCMSC)-derived extracellular vesicle nebulization inhalation therapy for the treatment of chronic cough after COVID-19 infection. The main objective is to assess whether UCMSC-derived exosome nebulization inhalation therapy alleviates chronic cough after COVID-19. Participants will be asked to complete a questionnaire to help researchers evaluate their cough severity and to record their scores before nebulization inhalation of UCMSC-derived exosomes. Participants will receive either continuous nebulized inhalation of UCMSC-derived exosomes for 5 days, twice daily, … |
JIHUI DU; | 2023-02-15 |
| 392 | Recruitment-to-inflation Ratio to Set Positive End-expiratory Pressure for Laparoscopic/Robotic Surgery: A Multicenter Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present investigation is focused to assess the effects of positive end-expiratory pressure (PEEP) on respiratory system compliance in obese patients invasive mechanical ventilation for laparoscopic or robotic surgery with pneumoperitoneum |
GIANMARIA CAMMAROTA; | 2023-02-15 |
| 393 | Defining A Noninvasive Signature for Pulmonary Vascular Remodeling in Group 3 PH PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main goal of this study is to develop a noninvasive signature for pulmonary vascular remodeling in Group 3 PH patients, using hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI). Such a signature may identify Group 3 PH responders to PAH-specific therapies. PAH’s unique 129Xe MRI signature has been shown in previous studies. Past studies have lacked a pathologic ground truth correlate of these signatures, … |
BASTIAAN DRIEHUYS; | 2023-02-15 |
| 394 | The Effect of Post-Discharge Multiple Nursing Interventions on The Number of Hospital Admissions, Dyspnea Level, and Quality of Life in COPD Patients Receiving Home Oxygen Therapy: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by persistent airflow obstruction and chronic respiratory symptoms or alpha-1-antitrypsin deficiency in response to inhaled cigarette smoke or other irritants. The excessive morbidity and mortality associated with COPD acute exacerbations represent a significant public health problem that places a high burden on patients, their families and society. In frequent and severe exacerbations, patients may experience a decrease in quality of life, depression, and even death up to one year after hospitalization. Costs associated with COPD are more than $15.5 billion, … |
HASAN BAKIR; | 2023-02-15 |
| 395 | Risk Stratifying COPD Exacerbations: A Prospective Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To identify clinical characteristics on presentation which predict differential outcomes in patients with exacerbation of COPD. |
WONG CHARLES; | 2023-02-01 |
| 396 | Integrated Personalized Care for Patients with Advanced Chronic Diseases to Improve Health and Quality of Life PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ADLIFE is a EU-funded project developing innovative digital health solutions to support healthcare planning and care delivery for patients with advanced chronic conditions (chronic obstructive pulmonary disease and/or heart disease failure). ADLIFE’s technology innovations will be deployed, used and evaluated in seven healthcare environments in Spain, the UK, Sweden, Germany, Denmark, and Israel. ADLIFE intends to impact three stakeholders: patients, informal caregivers and health professionals, and consequently across the seven participating international healthcare systems. ADLIFE intervention aims at slowing down the patients’ functional deterioration, ensuring their quality of life and promoting shared decision making, reducing the caregiver burden, … |
BIOSISTEMAK INSTITUTE FOR HEALTH SYSTEMS RESEARCH | 2023-02-01 |
| 397 | Holistic Wellbeing in COPD: The Communication About Sexuality (COSY) Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess the effectiveness of a communication intervention about sexuality on quality of life and other outcomes like physical activity, exercise capacity and health status in people with chronic obstructive pulmonary disease (COPD). |
ANJA FREI; | 2023-02-01 |
| 398 | Screening Moderate to Severe Obstructive Sleep Apnea With Wearable Device PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to find the best method to use Wellue O2 ring to screen for moderate to severe obstructive sleep apnea. The method that investigators use to screen for moderate to severe obstructive sleep apnea is oxygen desaturation index(ODI). The main questions of this study are 1. What is the best ODI to screen for moderate to severe obstructive sleep apnea? 2. What are the sensitivity, specificity and AUC of the study? In this study, … |
JAMES TISYAKORN; | 2023-02-01 |
| 399 | Microbial Colonization in Lung Cancer Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Aim: -To determine the prevalence and pattern of bronchial colonization in patients presenting with lung cancer at the time of diagnosis Secondary Aim: -To assess the potential demographic, clinical, radiological and histological predictors of colonization in patients with lung cancer |
TASNEEM HASSAN YOUNES; | 2023-02-01 |
| 400 | The Effect of Close Follow-Up Home Based Pulmonary Rehabilitation on Exacerbation Frequency and Hospital Admission in Severe COPD Cases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a randomized controlled trial. The cases will be divided into two groups as the Homespirometer group and the control group. Breathing exercises, aerobic exercise and peripheral muscle strengthening will be performed in both groups. A home-type spirometer will be given to the homespirometer group and it will be requested to send the spirometric measurement every week. The cases will be called to the hospital for control and evaluated at baseline, 3rd, 6th and 12th months. Evaluations include assessments such as exercise capacity measurement, muscle strength measurement, disease attack frequency, symptom scoring. |
ESRA PEHLIVAN; | 2023-02-01 |
| 401 | Heterogeneity and Disease Development of Early Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the clinical characteristics and heterogeneities of early chronic obstructive pulmonary disease (COPD), to determine the disease development of early COPD, and to establish a multidimensional model for predicting the outcomes of early COPD. |
JIEPING LEI; | 2023-02-01 |
| 402 | The Rehabilitation Complexity Scale (RCS) in Pulmonary Rehabilitation: Utility and Limitations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In August 2021, the Italian Ministry of Health published the Ministerial Decree to define the Criteria for the appropriateness concerning the access to hospital rehabilitation admission (in neurological, respiratory, cardiological, and orthopedic Units), classifying patients by complexity, the severity of disability and the number of ICD-9 discharge codes. The Appropriateness Decree adopted some fundamental criteria used in the United Kingdom for over 10 years (2009) where the Ministry of Health defined 3 levels of specialized rehabilitation based on the different complexity of the patient’s needs. Among the scales, … |
ISTITUTI CLINICI SCIENTIFICI MAUGERI SPA | 2023-01-30 |
| 403 | EMBOSS: Reach and Effect of A Person-centred Integrated-care Approach for Chronic Diseases and MultimorBidity in Patients of Low SOcio- Economic StatuS in General Practice PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: People of low socio economic status (SES) more often than others suffer from chronic diseases like diabetes mellitus, chronic obstructive pulmonary disease (COPD), or coronary diseases. Compared to others they more often have to deal with multiple diseases (multimorbidity) and they experience worse health outcomes. Their health literacy is often low. Current chronic disease management programs focus on reducing the burden of a single disease by prescribing medication, protocoled monitoring routines, or lifestyle advice. However, the effectiveness of these interventions is low in people with low SES, … |
RADBOUD UNIVERSITY MEDICAL CENTER | 2023-01-29 |
| 404 | Comparing Morning and Evening Dosing of Inhaled Long-Acting Muscarinic Antagonists for The Prevention of Hospitalization Requiring AECOPD or Death from All Causes – The LAMA By Night Study Utilizing A Comprehensive Nationwide Digital Platform for Recruitment Into A Pragmatic Randomized Controlled Trial Integrated with National Registries to Follow Outcomes PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: To examine, among once-daily LAMA using COPD patients, whether evening administration of LAMA is superior with respect to the incidence of hospitalization requiring AECOPD or death from all causes than the more conventional morning administration. |
CHRONIC OBSTRUCTIVE PULMONARY DISEASE TRIAL NETWORK DENMARK | 2023-01-27 |
| 405 | Clinical Study on The Safety and Efficacy of Mesenchymal Stem Cell Exosomes in The Treatment of Coronavirus Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study aims to investigate the safety and efficacy of nebulized inhalation of extracellular vesicles derived from mesenchymal stem cells combined with standard therapy for COVID-19-infected individuals. The primary objective is to determine whether nebulized MSC-secreted extracellular vesicles may be a feasible approach to alleviate COVID-19-induced lung injuries and promote recovery. Participants will be allocated to receive either nebulized MSC-secreted extracellular vesicles twice a day (BID) for 5 days as the test group or nebulized saline solution twice a day for 5 days as the control group. Researchers will compare the test and control groups to evaluate the safety and efficacy of extracellular vesicles in combination with standard therapy. |
XIAOYING HUANG; | 2023-01-23 |
| 406 | Evaluation of Frailty, Hand Grip Strength, Physically Activity, Kinesiophobia and Fatigue in Chronic Obstructive Pulmonary Disease and Asymptomatic Geriatric Individual PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The literature does not provide sufficient information on the evaluation of frailty, handgrip strength, physical activity, kinesiophobia, and fatigue in elderly individuals with Chronic Obstructive Pulmonary Disease and asymptomatic elderly individuals. Additionally, there is a gap in the literature regarding the impact of COPD on these parameters in geriatric individuals diagnosed with Chronic Obstructive Pulmonary Disease . To fill this gap in the literature and to establish treatment approaches based on the results of parameters studied in elderly individuals with Chronic Obstructive Pulmonary Disease in future studies. |
MERAL SERTEL; | 2023-01-21 |
| 407 | A Multicenter Double-blind Randomized Controlled Trial of Systemic Corticosteroid Therapy in AECOPD Patients Admitted to Hospital With Higher Blood Eosinophil Levels PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is one of the top three causes of death worldwide now. Acute exacerbations (AEs) of COPD are a risk factor for lung function deterioration, poor quality of life, longer hospitalization, and increased mortality. To date, COPD is associated with a heavy clinical and socioeconomic burden, of which AEs of COPD account for a significant part of the cost of patients with COPD. Although several retrospective cohort studies and post-hoc analyses from randomized controlled trials (RCTs) showed that AECOPD patients with higher blood eosinophils had a shorter length of hospital stay (LOS), … |
ZHAOHUI TONG; | 2023-01-16 |
| 408 | A Randomized, Double-blind, Placebo Controlled, Single and Repeat Dose Study to Assess The Safety, Tolerability, and Pharmacokinetics of Inhaled GSK3923868 in Participants With Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a two parts study, a single ascending dose followed by 14-days repeat dosing. The single ascending dose part will assess two dose levels of GSK3923868 or placebo across two treatment periods 1 and 2 in a single cohort of participants with a washout period of a minimum of 5 days after each treatment periods. The repeat dose part will assess repeated one dose level of GSK3923868 or placebo in treatment period 3 with up to 14 days of follow up in the same cohort of participants. The duration of study participation for treatment period 1, … |
GLAXOSMITHKLINE | 2023-01-13 |
| 409 | Air Filtration to Improve Indoor Air Quality (IAQ) and Chronic Obstructive Pulmonary Disease (COPD) Outcomes in A High-risk Urban Population of U.S. Military Veterans PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to investigate the effectiveness of stand-alone air filtration for improving indoor air quality (IAQ) and chronic obstructive pulmonary disease (COPD) outcomes in a high-risk urban cohort of 80 U.S. military veterans with COPD. Additional secondary goals of the study are to (1) investigate housing-related factors that may contribute to COPD exacerbation, (2) investigate the utility of using low-cost sensors for indoor air pollution epidemiology studies and for providing actionable or useful information on the quality of their indoor air to patients and their physicians, … |
BRENT STEPHENS; | 2023-01-11 |
| 410 | Rethinking Pulmonary Rehabilitation for Patients With COPD: A Three-arm Randomised Multicentre Trial (REPORT-trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary rehabilitation (PR) is one of the cornerstones of care for people with COPD together with smoking cessation and medical treatment. Despite the compelling evidence for its benefits, pulmonary rehabilitation is delivered to less than 30% of patients with COPD. Access to PR are particularly challenging, and especially for those with the most progressed stages of the disease. Pulmonary Tele-rehabilitation (PTR) and Home-based pulmonary rehabilitation (HPR) are two emerging models using health-care supportive technology that have proven equivalent to the conventional PR programs in patients with COPD who are able and willing to participate in conventional PR. However, … |
HENRIK HANSEN; | 2023-01-10 |
| 411 | Evolution of Pulsed Oxygen Saturation Throughout An Interval Training Session Compared to A Continuous Training Session in Patients With Chronic Obstructive Pulmonary Disease With Exercise-induced Oxygen Desaturation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients. The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session. |
GUILLAUME PRIEUR; | 2023-01-10 |
| 412 | Automated Oxygen Titration in Daily Life of Patients With Chronic Obstructive Pulmonary Disease on Home Oxygen Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sixteen patients with COPD and long term oxygen treatment (LTOT) will be included in the study. An automated home oxygen titrations (HOT) device will be attached to the patient´s home oxygen equipment. For 2×4 consequent days, the patients will be monitored and saturations, oxygen flow and physical activity level will be registered. In randomized order, … |
LINETTE MARIE KOFOD; | 2023-01-10 |
| 413 | Effect of Combined Upper and Lower Extremity Endurance Training Versus Lower Extremity Training Alone on ADL and Walking in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease with related exercise intolerance and marked disability due to symptoms such as dyspnea and fatigue. Effort intolerance and exercise-induced symptoms cause marked impairment in completing activities of daily living (ADL). Pulmonary rehabilitation (PR), which has exercise as a major component, is considered a key treatment in the management of COPD since PR is effective in improving exercise tolerance, exercise-induced dyspnea and fatigue, and health-related quality of life. Rehabilitation is also effective in improving the time required to perform ADLs, … |
ISTITUTI CLINICI SCIENTIFICI MAUGERI SPA | 2023-01-10 |
| 414 | Roflumilast Versus Methotrexate in The Treatment of Psoriasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor, which is approved in its oral form for chronic obstructive pulmonary disease, and in its topical form in the treatment of plaque psoriasis. Methotrexate is one of the conventional systemic treatments of psoriasis, so the aim of this study is to compare the efficacy and safety of roflumilast and methotrexate in the treatment of psoriasis |
DINA SAADI; | 2023-01-09 |
| 415 | TCM Daoyin Therapy in Early Chronic Obstructive Pulmonary Disease: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable disease. The aim of prospective randomized study is to evaluate the effects of TCM Daoyin training on Individuals at-risk for COPD. |
LU YING; | 2023-01-03 |
| 416 | Nasal High Flow (NHF) in COPD – Effects on Ventilation With Asymmetrical Nasal Cannulas (NHFDuet) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this controlled randomized crossover study is to compare the physiological effects of nasal high flow therapy (NHF) with 2 different nasal cannulas in patients with exacerbated chronic obstructive pulmonary disease (ECOPD) and chronic respiratory failure. 20 patients will be treated with NHF therapy (Airvo, Fisher&Paykel Healthcare, NZ) during wakefulness. Physiological measuremends will take place over three perdiods (visits). One period without NHF, one with NHF via standard cannula (Optiflow M) and one with asymmetrical cannula (Optiflow Duet) in randomised order. |
GEORG NILIUS; | 2023-01-02 |
| 417 | Effects of Increasing Mean Arterial Pressure on Renal Function in Patients with Shock and with Elevated Central Venous Pressure : A Pilot Study for The Individualization of Mean Arterial Pressure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure. |
PIERRE ASFAR; | 2023-01-02 |
| 418 | Association Between Frailty and Postoperative Adverse Outcomes in Patients Undergoing Urological Surgery PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: Frailty is a clinical condition associated with aging that is characterized by a decline in physiological capacity involving multiple organ systems. Previous research has established a strong correlation between frailty and increased mortality and morbidity risk after surgery. The 5-item modified frailty index (mFI-5) is a recent tool used to assess frailty. The aim of the present study was to use the mFI-5 to identify frailty and its association with postoperative adverse outcomes, including mortality and morbidity, among patients who underwent urologic procedures. |
CHAO-SHUN LIN; | 2023-01-01 |
| 419 | TOwards A Patient Centred MulTIMorbidity Approach FOR Chronic Disease MAnagement in Primary Care (OPTIMA FORMA) PHASE 3: Cluster Randomized Controlled Evaluation Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic diseases and multimorbidity are increasingly prevalent. However, over the last decades, attempts at improving primary care for chronic diseases have been focussed on the management of individual chronic diseases and single disease management (SDM) programs have been implemented in Dutch primary care. This causes multiple problems for patients with one or more chronic diseases, such as negative interaction between treatment of single diseases, high treatment burden, negative patient experiences, lack of attention for problems in other domains of life that may interact with the chronic disease, … |
RADBOUD UNIVERSITY MEDICAL CENTER | 2023-01-01 |
| 420 | Characterization and Definition of Right Ventricular Injury in Patients Admitted to Intensive Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The adequate characterization of RV injury is currently unknown. The hypothesis is that the best characterization of RV injury is the one with the most significant impact on the response to fluids and on the outcome. An RV failure is expected to induce fluid-unresponsiveness and potentially worst outcome. The main objective is to characterize different types of RV injury in critically ill patients by examining their association, including predictive performances, in hemodynamics parameters, ventilation parameters, and clinical outcomes The study will be based on the realisation of an echocardiography within 48 hours following inclusion. |
ANTOINE VIEILLARD-BARON; | 2023-01-01 |
| 421 | Community-based Pulmonary Rehabilitation (COPD Wellness) and Social Navigation (Health Advocates) to Improve Outcomes in Vulnerable Patients With COPD PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD), one of the leading causes of death in the US, disproportionately affects low socioeconomic communities. While few interventions effectively modify the course of COPD and improve outcomes, pulmonary rehabilitation is the one notable exception. However, implementation of this resource-intensive program in real-life settings, and in particular, for underserved communities, has proven to be challenging. Safety-net centers that serve primarily under-insured populations lack financial resources to provide pulmonary rehabilitation. The 10-week COPD Wellness and Plus+ Program directly addresses this gap, and yet, programs like these do not automatically lead to improved outcomes, … |
NEETA THAKUR; | 2023-01-01 |
| 422 | A Randomized Controlled Trial Investigating The Efficacy and Safety of Cardio® in Patient With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Research has over decades showed that marine food carries nutritional characteristics that promote human health. As seen in epidemiological studies and based on in vitro and in vivo studies, it is hypothesized that unrefined salmon oil as dietary supplement have anti-inflammatory effect. However, there is sufficient preliminary data to indicate bioactive compounds effect for clinical use, and further clinical trials investigating effect are needed. This trial will investigate the potential anti-inflammatory effect and reduction in the risk of cardio artery disease in patients diagnosed with chronic obstructive disease, COPD. |
DAG ARNE L HOFF; | 2023-01-01 |
| 423 | Validation of Emergency Surgery Score (ESS) As Outcome Prediction Score in Egyptian Patients Undergoing Emergency Laparotomy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the accuracy of Emergency Surgery Score in predicting postoperative morbidity and mortality in emergency laparotomy. |
DOAA AHMED MOHAMED; | 2023-01-01 |
| 424 | Effect of Azithromycin With ICS/LABA in Non-eosinophilic Chest Tightness Variant Asthma: A Multicentre Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Bronchial asthma (abbr. asthma) is one of common airway chronic inflammatory disease which usually threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually happened at night or in early morning. However, there are still some patients who persist only clinical manifestations of chest tightness, namely, chest tightness variant asthma (CTVA). This subgroup of asthma usually lacks asthma-specific clinical features, therefore, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2023-01-01 |
| 425 | Validation By Three-dimensional Actimetry Measurements of A Predictive Algorithm for Excessive Inactivity in Chronic Obstructive Pulmonary Disease (COPD) Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Recently, the principal investigator published an EI predictive Machine Learning algorithm based solely on clinical data, without any physical activity measures, collected from 1 409 patients. The GOLD standard of EI was defined on the basis of interrogation criteria. Patients considered as EI reported walking less than 10 minutes per day on average, and the pulmonologist judged that the patient had mainly domestic activities. Despite the subjective nature of the GOLD standard, the algorithm validated on a test sample had an error rate of only 13.7% (AUROC: 0.84, CI95% [0.75-0.92]). In the total study population (n=1409), … |
BERNARD AGUILANIU; | 2023-01-01 |
| 426 | RehabGBs: Rehabilitation in People With Guillain-Barré Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Guillain-Barré syndrome (GBS) is a neurological disease characterized by an inflammation of peripheral nerves, which might be responsible for long-term disability. Respiratory muscle weakness is a complication of GBS and might be responsible for respiratory symptoms, inadequate secretion clearance or hypoventilation, with negative impact on daily life. Inspiratory muscle training has been applied in respiratory and neurological diseases and benefits have been observed in symptoms (e.g., dyspnoea), pulmonary function, exercise capacity and quality of life. Nevertheless, results of this intervention in people with GBS are yet unknown. Moreover, … |
CENTRO DE REABILITACAO DO NORTE | 2023-01-01 |
| 427 | Neural Respiratory Drive of Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate the relationship among the neural respiratory drive (NRD), the sensation of the dyspnea and the effect of the bronchodilator on each stage COPD patients. |
ZHANG JIANHENG; | 2023-01-01 |
| 428 | Influence of Nasal High-flow Therapy (NHFT) on Ventilation and Sympathetic Drive in Patients With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen University Hospital). Overactivity of the sympathetic nerve activity (SNA) axis with centrally increased heart rate and peripheral vasoconstriction is a known phenomenon in patients with systolic heart failure (HF) and has recently been described in patients with primary lung diseases as in chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH). Comprehensive studies investigating sympathetic drive in Asthma as one of the major pulmonary diseases are still lacking. Furthermore, … |
JENS SPIESSHOEFER; | 2023-01-01 |
| 429 | Investigating The Role of Skeletal Muscle Dysfunction on Dyspnea and Exercise Intolerance in Interstitial Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnea (i.e. breathlessness) and exercise intolerance are common symptoms for patients with interstitial lung disease (ILD), yet it is not known why. It has been suggested that muscle dysfunction may contribute to dyspnea and exercise intolerance in ILD. Our study aims to: i) examine differences in the structure and function of the leg muscles in ILD patients, ii) determine if leg muscle fatigue contributes to dyspnea and exercise limitation in patients with ILD, and iii) determine the effects of breathing extra oxygen on leg muscle fatigue, as well as ability to exercise in ILD patients. |
JORDAN GUENETTE; | 2023-01-01 |
| 430 | Determinants of Balance in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of our study is to examine the relationship between balance and respiratory function, respiratory and peripheral muscle strength, functional capacity, and cognitive function in patients with Chronic Obstructive Pulmonary Disease (COPD). The secondary aim of our study is to compare respiratory function, respiratory and peripheral muscle strength, functional capacity, balance, and cognitive functions of COPD patients and healthy individuals. This study will examine and record the participant’s sociodemographic information and medical records. Balance, respiratory function, respiratory and peripheral muscle strength, functional capacity, and cognitive function will be assessed. Since the patients are included in this study, … |
HIKMET UCGUN; | 2023-01-01 |
| 431 | Impact of The Active Cycle of Breathing Technique and Pursed Lip Breathing With TheraPep on People With Acute Episode of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the short-term effects of two different breathing techniques (the active cycle breathing technique (ACBT) and the pursed lip breathing technique (PLB)) with Thera PEP® on the clearance of secretions and the oxygen saturation of individuals who have recently experienced an acute exacerbation of chronic obstructive pulmonary disease (COPD) in individuals who have recently experienced an acute exacerbation of COPD (COPD). Thirty patients will each have an acute COPD exacerbation seen on them, and then they will be randomly allocated to one of two groups (1. ACBT and PLB; … |
MOHAMMAD ABU SHAPHE; | 2022-12-30 |
| 432 | A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate The Efficacy and Safety of Astegolimab in Patients With Chronic Obstructive Pulmonary Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the efficacy and safety of astegolimab compared with placebo in participants with chronic obstructive pulmonary disease (COPD) who are former or current smokers and have a history of frequent exacerbations. |
HOFFMANN LA ROCHE | 2022-12-29 |
| 433 | The Effect of A Digital Therapeutics Program on Inhaled Medication Adherence in Patients With Chronic Obstructive Pulmonary Disease：a Prospective, Open-label, Randomized Controlled Clinical Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Digital Therapeutics (DTx) is an evidence-based，clinically evaluated software to treat，manage，and prevent a broad spectrum of diseases and disorders according to Digital Therapeutics Alliance，which may improve the adherence of patients with chronic obstructive pulmonary disease (COPD) to use inhaled medication and reduce the risk of acute exacerbation. This study plans to carry out a randomized controlled trial (RCT), using digital therapy to record and manage the behavior data of patients with COPD in the process of using inhaler medication, and analyze the correlation between digital therapy of COPD and patients’ drug compliance and treatment effect. |
TING YANG; | 2022-12-20 |
| 434 | A Phase I/II Randomized, Double Blinded, Placebo Trial to Evaluate The Safety and Potential Efficacy of Intravenous Infusion (IV) of ZofinTM for The Treatment of Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase I/II Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Intravenous Infusion (IV) of Zofin for the Treatment of Chronic Obstructive Pulmonary Disease (COPD). |
ORGANICELL REGENERATIVE MEDICINE | 2022-12-18 |
| 435 | Evaluation of Balance, Physical Activity, Functional Capacity and Activities of Daily Living in Frail Elderly Individuals With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is conducted on the evaluation of balance, physical activity, functional capacity and activities of daily living in frail elderly individuals with COPD. |
MERAL SERTEL; | 2022-12-15 |
| 436 | EzPAP Therapy Versus Non-invasive Ventilation for Hypercapnic Chronic Obstructive Pulmonary Disease Exacerbataion: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compared EzPAP and noninvasive treatments of hypercapnic COPD attacks. |
OYA GUVEN; | 2022-12-15 |
| 437 | Personalized Biomedical Risk Assessment for Smoking Cessation in Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study assesses the effect of a personalized smoking cessation infographic on physician smoking cessation counseling rates and smoking cessation pharmacotherapy prescription rates. The study assesses the difference in physician behaviour using an interrupted time series analysis (one-year pre vs. one-year post-intervention). General practitioners, nurse practitioners and respirologists who refer eligible patients (COPD, active smoking) for spirometry at the St. Michael’s Hospital Pulmonary Function Lab will receive the infographic. This is a quality improvement initiative. The smoking cessation infographic uses individualized patient data (height, weight, sex, baseline FEV1, … |
SAMIR GUPTA; | 2022-12-12 |
| 438 | Validating The Use of Frailty Measurements to Predict Care Expectations and Deteriorations in Quality of Life Among People With COPD: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research program is to validate frailty measurements as a risk stratification tool to predict deteriorations in patient-reported outcomes, to gain a better understanding of patient preferences for care within varying degrees of frailty, and to assess differences in frailty measurement between patients and their clinicians. This work will provide a foundation in the development of customized interventions for people with COPD and varying degrees of frailty, with the goal of improving quality of life and optimizing health system service delivery for patients and their care givers. |
SUNITA MULPURU; | 2022-12-12 |
| 439 | A Single-dose, Open-label, Multi-center, Randomized, 2-treatment Crossover Study to Compare The Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Acetylsalicylic Acid Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Adult Subjects With Obstructive or Restrictive Pulmonary Function PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the pharmacokinetics (PK) pharmacodynamics (PD), safety and tolerability of acetylsalicylic acid powder for oral inhalation (I-ASA) with non-enteric-coated chewable aspirin (C-ASA) in adult subjects with obstructive or restrictive pulmonary function. In the first treatment period, subjects will be randomized to receive either a single dose (100 mg) of I-ASA powder via a Dry Powder Inhaler (DPI) OR a single dose (162 mg) of C-ASA tablets. After a washout period, … |
PAUL GURBEL; | 2022-12-10 |
| 440 | Effects of Sugammadex and Conventional Reversal on Lung Function in Laparoscopic Abdominal Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clincal trial is to determine the differences in few parameter of lung function (ie Forced Vital Capacity (FCV)) between Sugammadex and conventional reversal in laparoscopic abdominal surgery. The main questions it aims to answer are: 1. Is there differences in the pulmonary function test preoperative and post extubation between Sugammadex and conventional reversal in laparoscopic abdominal surgery? 2. Is there differences in the size of atelectasis area between Sugammadex and conventional reversal in laparoscopic abdominal surgery? 3. Is there differences between sugammadex and conventional reversal in postoperative mean length of stay in laparoscopic abdominal surgery? Participants will be asked 1. to do baseline spirometry before operation 2. to be examined for lung ultrasound before operation 3. to be given either sugammadex or neostigmine as reversal after operation is completed 4. to repeat spirometry after operation for few times 5. to be examined for lung ultrasound after operation Researcher will compare sugammadex group and conventional group to see if any difference in term of lung function, size of atelectasis and length of stay. |
RHENDRA HARDY MOHAMAD ZAINI; | 2022-12-07 |
| 441 | Palliative Care Costs for Oncologic and Non-oncologic Patients Under Different Outpatient Management in Catalunya PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cost-of-illness studies in palliative care (PC) are a growing area of interest in health economics activity. They are, in part, stakeholders’ basis for deciding the allocation of the scarce public and private economic resources. There is no standard methodology to capture the formal and informal costs and expenses that health services and patients and their caregivers make during the PC attention period due to non-standard health services, and data capture approaches. |
JORDI GOL I GURINA FOUNDATION | 2022-12-05 |
| 442 | A Study to Investigate The Association of Real-world Sensor-derived Biometric Data With Clinical Parameters and Patient-reported Outcomes for Monitoring Disease Activity in Patients With Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this multicenter, prospective cohort study is to investigate the correlation of real-world sensor-derived biometric data obtained via a wearable device with clinical parameters and patient-reported outcomes (PROs) for monitoring disease activity and predicting exacerbations for participants with Chronic Obstructive Pulmonary Disease (COPD). The cohort of participants with COPD will be followed for 3 months. A calibration cohort with non-COPD participants will be included and followed for 2 weeks. |
MERCK HEALTHCARE KGAA DARMSTADT GERMANY AN AFFILIATE OF MERCK KGAA DARMSTADT GERMANY | 2022-12-05 |
| 443 | Investigation of Impairments in Body Functions and Structures, Activities and Participation Restrictions According to The ICF Framework in Chronic Obstructive Pulmonary Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This cross-sectional study aims to investigate to the impairments in body functions and structures, activities and participation restrictions according to the International Classification of Functioning, Disability and Health (ICF) framework in Chronic Obstructive Pulmonary Diseases (COPD) patients. |
TANSU BIRINCI; | 2022-12-05 |
| 444 | The Effect of Health Coaching on Perceived Social Support in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to determine the effect of the health coaching approach applied to patients with Chronic Obstructive Pulmonary Disease on the perceived social support of the patients. Research Hypotheses: H0: Health coaching approach has no effect on perceived social support in patients with COPD. H1: Health coaching approach has an effect on perceived social support in patients with COPD. |
DERYA TÜLÜCE; | 2022-12-01 |
| 445 | Clinical Feasibility of A Non-invasive Wearable Acoustic Device for Measuring Air Trapping in COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot observational study during which the investigators will conduct a longitudinal assessment of air trapping (with up to 2 visits) in 40 patients with COPD and variable degrees of air trapping and 20 healthy controls using ARIA. The investigators will characterize the clinical phenotype of the subjects by administering health and symptom-based questionnaires and obtaining lung function testing at rest and during exertion, and will then correlate and validate the ARIA-based indices with those of the more traditional physiologic measures of static and dynamic air trapping. |
GANESH KRISHNA; | 2022-12-01 |
| 446 | Effect of An Individual Counseling Session on Physical Activity Level of Individuals with Chronic Obstructive Pulmonary Disease (COPD) – Randomized Controlled Study (RCT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to study the effect of an individual counseling session on the level of physical activity and motivation to practice physical exercise in individuals with COPD. The main question\[s\] it aims to answer are: • Does a counseling session improve the level of physical activity and motivation to practice physical exercise in individuals with COPD? Participants will perform a respiratory rehabilitation program (Control Group, CG) and a respiratory rehabilitation program and the counseling session (Experimental Group, … |
TIAGO MIGUEL DOS SANTOS PASTILHA; | 2022-12-01 |
| 447 | Safety and Effectiveness of EV-Pure + WJ-Pure Treatment on Pulmonary Fibrosis Secondary to Covid-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-induced fibrotic lung damage continues long after viral infection has subsided and is exhibited by severe respiratory pathology and concomitant symptoms. The long-lasting sequelae in patients who have recovered from severe COVID indicate that there is a 30% chance of developing a persistent respiratory system pathology and a 10% chance of developing a severe pathology. The symptoms of lung fibrosis include a severe disruption of respiration, reduction of exercise tolerance, and concomitant development of persistent fibrotic lung damage. This study intends to evaluate benefits of a combination of WJPure and EVPure in Covid-19 patients exhibiting pulmonary fibrosis. |
VITTI LABS | 2022-11-30 |
| 448 | A Prospective, Multicentre, Cluster Randomised Controlled Trial to Evaluate The Impact of The Implementation of COPD Quality Standards in High Exacerbation Risk Patients——- A COPD Quality Improvement Program（QIP） PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: QIP(Quality Improvement Programme) is a COPD quality improvement program in China. The initial step of this program is to set up the Quality Standards(QS) of COPD management in clinical practice, then embed Quality Standards into routine care and uses Quality Control Indicators (QCI)to check the QS implementation. The aim of the QIP program is to standardize COPD management in clinical practice in China, including the standardization of diagnosis, assessment, pharmacological and non-pharmacological intervention, and follow-up. COPD patients can benefit from standardization clinical behaviours, to be identified early, be accessed comprehensively, and be treated correctly according to guidelines, … |
RONGCHANG CHEN; | 2022-11-25 |
| 449 | Translational Studies on Electronic Cigarette-derived Oxidants and Their Long-term Cardiopulmonary Effects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study on the impact of switching from cigarettes to Electronic Cigarettes (EC) on disease-related clinical symptoms and biomarkers of harm in smokers with preexisting Chronic Obstructive Pulmonary Disease (COPD). The researchers hypothesize that the smokers who switch to EC completely or significantly will experience reduced COPD symptoms, risks of exacerbations, and decreased levels of oxidative stress and inflammation. |
JOHN P. RICHIE; | 2022-11-22 |
| 450 | A Randomised, Double-blind, Placebo-controlled Study to Investigate The Safety and Tolerability of EP395 in Patients With Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this clinical trial is to investigate the safety and tolerability of oral, once-daily EP395 administration in COPD patients for 12 weeks. |
SUKH DAVE SINGH; | 2022-11-22 |
| 451 | The Effect of Music Therapy on Anxiety and Perceived Time in Pulmonary Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study explores the effects of music therapy intervention on anxiety and time perception during pulmonary rehabilitation. |
KE-YUN CHAO; | 2022-11-21 |
| 452 | GRIP: Evaluation of The Comparability of The Maximum Isometric Grip Strength Measurement Assessed with The JAMAR© Hydraulic Hand Dynamometer, The JAMAR© Smart Hand Dynamometer and The Martin Vigorimeter PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Maximum isometric grip strength (MIGS) is a cost-effective, easily accessible, valid and reliable outcome measure for assessing upper body strength in both, adults and children. The the JAMAR Hydraulic Hand Dynamometer is the current gold standard for measuring MIGS. For certain age- and activity-groups, alternative devices may be more appropriate. To date, the quality criteria (test-retest-reliability and validity) of the JAMAR Smart Hand Dynamometer and the Martin Vigorimeter compared to the current gold standard are not yet investigated. Furthermore, no reference values for different age-, sex-, … |
JOHANNES SCHERR; | 2022-11-17 |
| 453 | Utilizing Canadian Digital Technology to Prevent and Manage Diabetes, Obesity, and Heart Disease in Patients Living With Congestive Obstructive Pulmonary Disease – A Single-arm Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: People with Chronic Obstructive Pulmonary Disease (COPD) are at greater risk for Metabolic syndrome (MetS). Although the management of MetS will not cure COPD, it can beneficially impact health outcomes and quality of life through lifestyle modifications. The study aims to determine if using the Digital Metabolic Rehab program, which is based on preventive self-care and includes three key pillars of health: nutrition, fitness, and mindfulness, will be feasible to reduce or reverse MetS for individuals living with COPD. |
DOUG KLEIN; | 2022-11-17 |
| 454 | Does Severity of Airflow Obstruction Correlate to Static Lung Volumes Obtained By Nitrogen Washout and Body Plethysmography? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Obstructive lung disease is defined by limitations in expiratory airflow, caused by excess mucus, loss of muscle tone, and structural changes. Over time airflow reduction can lead to gas trapping in the lungs (hyperinflation). Hyperinflation is linked to diminished exercise tolerance, shortness of breath, and a poor quality of life. Early treatment options include inhalers and pulmonary rehabilitation; however, surgical intervention and oxygen therapy may be required in the later stages. More prompt, accurate diagnosis will help to improve patient outcomes and optimise their treatment pathways. Two methodologies used to determine lung volumes and hyperinflation, … |
VIRGINIA HAWKINS; | 2022-11-15 |
| 455 | Technical Validity and Clinical Feasibility of Using A Telerehabilitation System Using Advanced Telehealth Technologies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective study will be held in two steps. The aim of the first step is to assess the technical validity of transmitting data remotely from different devices connected to a telerehabilitation system. These will include real-time oximetry data during exercise on a cycle ergometer (heart rate and transcutaneous oxygen saturation) as well as daily step count from a commercially available physical activity tracker. The aim of the second step of the study is to assess the clinical feasibility of using the telerehabilitation system in real life conditions (in the home environment). Briefly, … |
TRISTAN BONNEVIE; | 2022-11-15 |
| 456 | The Effect of Maximal Strength Training on Lung Function in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the effect on maximal strength training on muscle function, lung function and quality of life for patients diagnosed with COPD grade II-III (Gold scale). Each patient will complete a total of 20 exercise session participating in a rehabilitation program for 4 weeks. Physiological and functional testing will be performed 4 weeks before the training intervention, at baseline and after the intervention period. |
JAN HELGERUD; | 2022-11-15 |
| 457 | A Phase 2a Randomised, Double Blind, Placebo Controlled, Parallel Arm, Multi-Centre Study to Evaluate The Efficacy and Safety of AZD4831 in Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a research study to evaluate the efficacy and safety of the investigational drug AZD4831 in adult participants with chronic obstructive pulmonary disease. |
ASTRAZENECA | 2022-11-14 |
| 458 | The Effect of Steady State Aerobic Training on Insulin Sensitivity on Diabetic Patients During Tobacco Cessation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: – Prevalence of smoking in men and women ages 15 and over who currently smoke any tobacco product on a daily or non-daily basis Egypt smoking rate for 2018 was 21.40%, a 0.1% increase from 2016. – According to WHO reports, smoking is currently responsible for six million premature deaths every year, of which 600 000 individuals die from the effects of second-hand smoke. – … |
ALAA MOHAMED NAGUIB ASHRY; | 2022-11-09 |
| 459 | The Impact of Pulmonary Rehabilitation on Respiratory Function and Quality of Life in Pediatric Patients With Chronic Lung Diseases: A Multidisciplinary Approach in Damietta Governorate PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic lung diseases (CLDs) such as asthma, cystic fibrosis, and bronchopulmonary dysplasia significantly impact pediatric patients’ respiratory function and overall well-being. Pulmonary rehabilitation (PR) has been shown to improve lung function, exercise tolerance, and quality of life in affected individuals. However, limited research has been conducted on PR implementation in Egypt. |
MOHAMED SALAH EL-SAYED; | 2022-11-01 |
| 460 | Dual Anti-platelet Therapy in Chronic Obstructive Pulmonary Disease Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 6 week crossover study in smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e. blood flow in the lungs measured on a contrast CT scan) compared to placebo. |
CARRIE PISTENMAA; | 2022-11-01 |
| 461 | Effect of Face Masks on Pulmonary Function in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Since COPD patients are at higher risk for severe illness in case of SARS-CoV-2-infection, precautions such as wearing masks are important for them. However, for this group of patients wearing a mask can lead to increased shortness of breath and discomfort. Aim of this study is to examine the impact of wearing a face mask during 6-Minute-Walking-Tests (6-MWT) in COPD patients. |
LUKASZ ANTONIEWICZ; | 2022-11-01 |
| 462 | Can Neurally Adjusted Ventilatory Assist Mode Reduce Mechanical Ventilation Day in Patients With Chronic Obstructive Pulmonary Disease ? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background： Neurally Adjusted Ventilatory Assist (NAVA) mode is a new mode of ventilator, using electronic potential of diaphragm to adjust tidal volume. At the same time, this mode can trigger and cycle-off inspiratory time by high sensitivity of electronic potential of diaphragm, increase patient-ventilator synchrony, reduce sedative drug, improve oxygenation, … |
FU JEN CATHOLIC UNIVERSITY HOSPITAL | 2022-11-01 |
| 463 | Pulmonary Diffusing Capacity to Nitric Oxide and Carbon Monoxide During Exercise in Patients With Chronic Obstructive Pulmonary Disease: A Test-retest Reliability Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) during exercise may be a useful physiological measure of alveolar-capillary reserve in patients with Chronic obstructive pulmonary disease (COPD). The present study investigated the test-retest reliability of DLCO/NO-based metrics. |
RONAN BERG; | 2022-11-01 |
| 464 | Airway Occlusion Measured During Non-invasive Ventilation to Assess Respiratory Effort PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-invasive ventilation (NIV) is extensively used in critical care settings and emergency departments for a variety of aetiologies but specially for acute respiratory failure (ARF). It eliminates morbidity related to the endotracheal tube and use of sedatives so it reduces intensive care unit (ICU) complications; however, on the other hand, the harmful effects of spontaneous breathing through the intensity of inspiratory effort may predispose the patient to the onset of self-inflicted lung injury (SILI). Therefore, … |
MARINA BUSICO; | 2022-10-30 |
| 465 | Automated Oxygen Titration to Improve Activities of Daily Living in Patients With Chronic Obstructive Pulmonary Disease on Home Oxygen PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the effect of automated oxygen titration compared to the usual fixed dose oxygen on the patient’s ability to perform activities of daily living. |
LINETTE MARIE KOFOD; | 2022-10-30 |
| 466 | Video Resources for People With Chronic Obstructive Pulmonary Disease: An Exploratory Qualitative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The IPCRG & Teesside University have searched the internet for video self management content for people living with COPD. Resources were reviewed by healthcare professionals and developed into a digital magazine to support people living with chronic obstructive Pulmonary Disease (COPD). The aims of this study are to 1. evaluate the use of the digital magazine format with video self-management content from an end user perspective, including 1. what characteristics a good video resource should have 2. what information is important to people with COPD to include in videos and digital magazines, … |
KIRSTI LOUGHRAN; | 2022-10-20 |
| 467 | Nurse-led Integrated Care of Complex Patients Facilitated By Telemonitoring: The Safe, Managed, and Responsive Transitions (SMaRT) Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In Canada, 3 out of 4 Canadians aged 65 and older have at least one chronic condition, while 1 in 4 seniors reported having three or more. Caring for complex patients who usually have multiple chronic conditions (MCC) is one of the biggest challenges facing our healthcare system. For patients, the lack of coordination and continuity of care as they transfer between healthcare settings and healthcare providers (HCPs) often results in a higher risk of readmission, suboptimal and fragmented care plans, delays in required medical intervention, inadequate self-care, … |
JANE DELACY; | 2022-10-17 |
| 468 | Use of A Digital App to Deliver Home-based Rehabilitative Interventions in Patients Affected By Respiratory Diseases: A Monocentric Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the feasibility and the mid-term effects of a pulmonary rehabilitation intervention, delivered by digital App, on quality of life of patients affected by respiratory diseases. The App will include a monitored exercise training program based on most recent cardiopulmonary rehabilitation guidelines, including alerts, reminders and educational contents as well as chat and online visits with healthcare professionals to improve patient engagement. |
MICHELE VITACCA; | 2022-10-17 |
| 469 | A 12-week, Prospective, Open Label, Single Cohort Study to Evaluate The Real-world Effectiveness of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol in A Single Inhaler (Trelegy Ellipta) in Symptomatic Chronic Obstructive Pulmonary Disease (COPD) Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the effectiveness of TRELEGY ELLIPTA on health status in participants with symptomatic COPD. The secondary objective is to evaluate the effectiveness of TRELEGY ELLIPTA on dyspnea and lung function in participants with symptomatic COPD. |
LEI WU; | 2022-10-14 |
| 470 | Can Micro-doses of Physical Activity Offset The Negative Cardiovascular Consequences of Being Sedentary in Patients With COPD? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than healthy individuals. Those who are the most sedentary have a greater risk of heart and blood vessel disease, … |
NEIL EVES; | 2022-10-12 |
| 471 | The Role of MiRNA in Group 3 Pulmonary Hypertension PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study recognizes the substantial value of lung tissue obtained from explanted lungs for fundamental research purposes.By analyzing pulmonary tissue affected by pulmonary hypertension, it is possible to discover shared pathogenetic mechanisms between these two groups and to gain a deeper understanding of the mechanisms underlying pulmonary hypertension. |
ELENA SALVATERRA; | 2022-10-10 |
| 472 | High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: high flow nasal cannula (HFNC) oxygen therapy utilizes an air oxygen blend allowing from 21 % to 1 00% FiO2 delivery and generates up to 60 L/min flow rates The gas is heated and humidified through an active heated humidifier and delivered via a single limb heated inspiratory circuit (to avoid heat loss and condensation) to the patient through a large diameter nasal cannula Theoretically, … |
ABDELRAHMAN ALHAM; | 2022-10-10 |
| 473 | Efficacy and Safety of Pembrolizumab As First-line Treatment for Advanced Non-small Cell Lung Cancer Complicated With Chronic Obstructive Pulmonary Disease: A Prospective, Single-arm, Single-center Phase II Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to evaluate the efficacy and safety of pembrolizumab in the first-line treatment of advanced NSCLC complicated with COPD and its influence on the course of COPD, so as to provide prospective clinical evidence for immunotherapy of NSCLC complicated with COPD in China and to guide clinical application. |
JIANWEN QIN; | 2022-10-10 |
| 474 | Effects of Face-to-face Versus Telematic Supervision During A Community-based Exercise Intervention (Urban Training) Plus Therapeutic Education Programme on Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This project plans on a community-based exercise intervention (Urban Training) combined with therapeutic education program, by using public spaces and urban walkable trails, adapted to each patient needs and capabilities in patients with chronic obstructive pulmonary disease (COPD). The main objective of the present study is to evaluate the effects comparing different levels of supervision (face-to-face vs telematic) in the short-, medium- and long-term with respect to: (primary outcome): exercise capacity, and (secondary outcomes): physical activity, quality of life, mental health and COPD exacerbations. |
TAMARA DEL CORRAL NÚÑEZ-FLORES; | 2022-10-05 |
| 475 | The Effect of Health Care Transition Based Education Program Given to Asthmatic Adolescents on Transition Readiness and Self-Efficacy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim: The purpose of this study was to examine the effect of health care transition-based education on transition readiness and self-efficacy in adolescents (14-18 years) with asthma through a randomized controlled experimental study that integrated the literature, model, and research on the transition from pediatrics to adult care. The research hypotheses are as follows: H0: There is no significant difference between the intervention and control groups’ mean Transition Readiness Assessment Questionnaire, … |
FATMA DİNÇ; | 2022-10-04 |
| 476 | Nasal Mucosal Immune Responses to Live Attenuated Influenza Virus (LAIV) in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Phenotypes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will determine the functional status of the nasal immune environment with LAIV exposure in COPD persons with frequent exacerbations (defined as individuals with two or more episodes of worsening in COPD symptoms requiring treatment with antibiotics and/or steroids in the prior 12 months) and COPD persons without frequent exacerbations to determine acute exacerbation of COPD (AECOPD)-associated dysfunction in a) cytokines and immune effector cells of the nasal mucosa and b) viral replication. The investigators hypothesize that: 1) COPD frequent exacerbators, compared to COPD infrequent exacerbators, will demonstrate altered mucosal immune responses to LAIV exposure, … |
MICHAEL B DRUMMOND; | 2022-10-03 |
| 477 | Exacerbations and Real-World Outcomes Among Chronic Obstructive Pulmonary Disease Patients Receiving Breztri (EROS Study) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: EROS was a retrospective analysis of people with COPD using the MORE2 Registry®. Inclusion required ≥1 severe, ≥2 moderate, or ≥1 moderate exacerbation while on other maintenance treatment. Primary outcomes were the rate of COPD exacerbations and healthcare costs for those that received BGF promptly. The effect of each 30-day delay in initiation of BGF was estimated using a multivariable negative binomial regression model. |
ASTRAZENECA | 2022-10-01 |
| 478 | Incidence and Risk Factors of Postoperative Pulmonary Complications in Elderly Patients Undergoing Robot Assisted Laparoscopic Pelvic Surgery: A Single Center, Prospective, Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Postoperative pulmonary complications are important factors affecting the prognosis of patients undergoing surgery. Studies have shown that patients undergoing abdominal or pelvic surgery, emergency surgery, or prolonged surgery are more likely to develop PPCs, especially when robot-assisted laparoscopic surgery is performed at extreme head low. The incidence of PPCs and associated risk factors in patients undergoing robot-assisted laparoscopic surgery compared with those undergoing conventional surgery should be re-examined. |
FENG GAO; | 2022-10-01 |
| 479 | Observational Study: Oxygen Therapy Monitoring in COPD Patients Using Connected Devices PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background : Long-term oxygen therapy is prescribed for patients with severe COPD. The aim of oxygen therapy is to administer oxygen at a concentration level higher than that of ambient air, in order to treat or prevent the symptoms and manifestations of arterial hypoxemia; this therapy can be applied either in an acute situation or as a long-term treatment, in cases of stabilized severe chronic hypoxemia. Currently, pneumologists do not have the possibility, between 2 consultations spaced several months apart, … |
ARI CHAOUAT; | 2022-10-01 |
| 480 | Effect of Neuromuscular Electrical Nerve Stimulation on Quadriceps Muscle Strength and Endurance in Patients With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a respiratory condition that results in a mixture of small airway disease and parenchymal destruction, changes that are characteristic of emphysema. COPD is also characterized by persistent airflow limitation, an aspect which is noted to be a major cause of morbidity and disease burden worldwide. One in every 8 patients who suffer an exacerbation requires to be admitted to the hospital. Due to repercussions that arise both because of the systemic effects of COPD and also the aggravating factors due to the exacerbation, … |
RANDALL DEBATTISTA; | 2022-10-01 |
| 481 | Interventional, Prospective, National, Multicentre, Randomised, Open-label, Controlled Clinical Study Comparing Two Parallel Groups, One Control Arm (Standard Treatment) Versus Intervention Arm (Standard Treatment + Study Product) Evaluating The Efficacy of Respicure® 0.38% /0.38% (Resveratrol / Quercetin) Phytotherapy Product From BEKER® Laboratories As An Add-on Treatment in The Management of Respiratory Conditions Including Asthma (Partially Controlled),Chronic Obstructive Pulmonary Disease COPD (Stage A, B, C and D) and Long Coronavirus Disease COVID in Algerian Adult Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Interventional, Prospective, National, Multicentre, Randomised, Open-label, Controlled Clinical Study Comparing Two Parallel Groups, One Control Arm (Standard Treatment) Versus Intervention Arm (Standard Treatment + Study Product) Evaluating the Efficacy of Respicure® 0.38% /0.38% (Resveratrol / Quercetin) Phytotherapy Product From BEKER Laboratories as an add-on Treatment in the Management of Respiratory Conditions Including Asthma (Partially Controlled),COPD (Stage A, B, C and D) and long COVID in Algerian Adult Patients . |
PR MERSAK GHARNAOUT; | 2022-10-01 |
| 482 | Effects of Diaphragm and Abdominal Muscle Training on Pulmonary Function Testing and Dyspnea Among Chronic Obstructive Pulmonary Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It will be a randomized control trial at Services Hospital Lahore through convenience sampling technique which will be allocated through simple random sampling through sealed opaque enveloped in to Group A and Group B . Group A: patients will be treated with basic breathing technique whereas Group B: will be treated by will be breathing technique along with diaphragm and abdominal training. The study will be completed within 6 months after synopsis approval from ethical Committee of RCRS & AHS . Data will be entered and analyzed by SPSS version 25. After assessing the normality of data , … |
WAJEEHA ZIA; | 2022-10-01 |
| 483 | Efficacy of High Frequency Chest Wall Oscillations Versus Lung Flute in Chronic Obstructive Pulmonary Disease Postcovid PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: COPD causes an acute deterioration of respiratory symptoms, particularly increased breathlessness and cough, and increased sputum volume and/or purulence. Worsening airflow limitation is associated with an increasing prevalence of exacerbations and risk of death. These exacerbations can range from self-limited diseases to episodes of florid respiratory failure requiring mechanical ventilation .Hospitalization for COPD patients post COVID is associated with poor prognosis with increased risk of death. Hence techniques of efficient clearance of peripheral airways may reduce airway occlusion by excess mucus and inflammatory cells, improving lung function, exercise capacity and reducing exacerbation frequency. |
ALAA MOHAMED EL-MOATASEM MOHAMED; | 2022-10-01 |
| 484 | Effect of Pulmonary Rehabilitation on Reducing Loneliness in Individuals With Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Loneliness is the feeling of sadness because one wants friends or company. This feeling is common in patients with chronic lung disease, who suffer from breathing difficulty, chronic cough, … |
DINA BROOKS; | 2022-10-01 |
| 485 | Immunological Basis for Mepolizumab Activity in COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The current literature suggests that the mode of action of mepolizumab is to bind with Interleukin (IL)-5 and block the interaction of IL-5 with the IL-5Ra receptor on eosinophils. This removal of IL-5 may not explain all of the effects of mepolizumab. The investigators propose a set of studies to systematically examine the spectrum of effects of this drug on the immune system. |
THOMAS ROGERS; | 2022-10-01 |
| 486 | Immunological Basis for Benralizumab Activity in Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The current literature suggests that the mode of action of benralizumab is to deplete eosinophils through a mechanism of antibody-dependent cell-mediated cytotoxicity. This direct cellular cytotoxicity may not explain all of the benralizumab effects. The investigators propose a set of studies to systematically examine the spectrum of effects of this drug on the immune system. |
THOMAS ROGERS; | 2022-10-01 |
| 487 | The Effect of Melatonin on Postoperative Pain Reduction After Orthognathic Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Orthognathic surgery is a procedure performed to correct dentofacial deformities. It involves osteotomy at the facial skeleton. Considerable pain is expected in the early recovery period. Melatonin is a hormone that is produced naturally by the body. Synthetic Melatonin is available over the counter for the management of sleeping disorder and jetlag. Clinically, Melatonin can also be used to reduce pain and analgesic consumption in patients undergoing surgery. Dexamethasone is a type of steroid. It can suppress the inflammatory response. It is an anti-inflammatory, … |
WINNIE WS CHOI; | 2022-10-01 |
| 488 | Effectiveness of Maintenance Treatment With Tiotropium + Olodaterol in Comparison to Inhaled Corticosteroids + Long-acting Β2 Agonists in COPD Patients in Taiwan: A Non-interventional Study Based on The Taiwan National Health Insurance (NHI) Data PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The real world study aims to assess effectiveness and safety profile between tiotropium/olodaterol (Tio/Olo) and inhaled corticosteroids(ICS) / Long-acting β2-agonists (LABA) in patients with chronic obstructive pulmonary disease (COPD) in Taiwan. The data used in this study will come from the Taiwan National Health Insurance (NHI) claims data between 2014 and 2019. |
BOEHRINGER INGELHEIM | 2022-09-30 |
| 489 | Safety Profile of Tiotropium + Olodaterol Used As Maintenance Treatment in COPD Patients in Taiwan: A Non-interventional Study Based on The Taiwan National Health Insurance (NHI) Data PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this real world study is to assess the safety profile of tiotropium/olodaterol (Tio/Olo). |
BOEHRINGER INGELHEIM | 2022-09-30 |
| 490 | Treatment of Pneumocystitis in COPD (the TOPIC Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease associated with chronic inflammation in the airways and lung, resulting in significant morbidity and mortality worldwide. Smoking is the primary risk factor for development of COPD and progression of the disease is associated with acute exacerbations of COPD (AECOPD) that can be triggered by acute bacterial or viral airway infections or can occur independently of infection. AECOPD can lead to hospitalization, progression of the disease, … |
MATTHEW SIMS; | 2022-09-28 |
| 491 | A Randomized, Double-Blind, 12-Week (With An Extension to 52 Weeks in A Subset of Participants), Multi-Center Study to Assess The Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate (BGF) Delivered By MDI HFO Compared to BGF Delivered By MDI HFA in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 12-week (with an extension to 52 weeks in a subset of participants) study comparing the safety of BGF MDI HFO twice daily (BID) with BGF MDI HFA BID in participants with moderate to very severe COPD. |
ASTRAZENECA | 2022-09-27 |
| 492 | Involvement of Skeletal Muscle Fibrocytes in SarcOpenia in Patients With Chronic ObstRuctive BronchopneumopaThia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is presently the third leading cause of death worldwide and is characterized by irreversible airflow limitation diagnosed by spirometry. COPD is currently considered as a systemic disease with predominantly respiratory involvement, associated with numerous comorbidities. Among these, muscle wasting, present in about one third of patients, is associated with a higher mortality (up to 10-fold, irrespective of the severity of the obstruction). Muscle wasting is classically characterized by a decrease in muscle strength and volume (sarcopenia), … |
PAULINE HENROT; | 2022-09-15 |
| 493 | Effects of Thoracic Kinesiotaping on Pulmonary Function and Functional Capacity of COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to determine the effects of diaphragmatic kinesiotaping (KT) facilitation technique on pulmonary function, functional capacity and forward head posture of chronic obstructive lung diseases (COPD) patients. The application of KT as an adjunct to conventional protocol in COPD patients if proven effective can enhance the symptom control in COPD patients for improving lung function, posture reducing the perception of dyspnea as well as improving functional capacity. |
SUMAN SHERAZ; | 2022-09-15 |
| 494 | Evaluation of An Algorithm That Can Detect COPD By Intelligent Terminal Device PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases. Early detection and treatment are critical to prevent the deterioration of COPD. In this study, we have established an algorithm that can detect and infer the severity of COPD from physiological parameters and audio data collected by wearable devices, and in this stage, we aim to evaluate the accuracy of this algorithm. |
GUANGFA WANG; | 2022-09-13 |
| 495 | The Relevance and Consistency Study of Changes in End Expiratory Lung Impedence Measured By EIT and End Expiratory Lung Volume Measured By Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping, dynamic pulmonary hyperinflation (DPH), therefore the intrinsic PEEP (PEEPi) increases. It is worthwhile to explore bedside methods to quantify the changes in dynamic pulmonary hyperinflation to guide safe and effective mechanical ventilation in airflow limited patients. |
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY | 2022-09-13 |
| 496 | Healthy at Home: Feasibility Trial of Home-Based Management of Patients With Chronic Obstructive Pulmonary Disease (COPD) Using Digital Technology PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective is to conduct a pilot-feasibility trial of the Healthy at Home program, a multimodal intervention aimed at preventing acute care needs among COPD patients. The program will feature a digital platform and virtual pulmonary rehabilitation to facilitate complex care management of UMass Memorial Health Patients |
APURV SONI; | 2022-09-09 |
| 497 | Pulmonary Adaptive Responses to HIIT in COPD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with chronic obstructive lung disease (COPD) suffer from a progressive loss of lung function that leads to poor quality of life, and often invalidity and early death. Regular exercise can improve quality of life in these patients, … |
RONAN BERG; | 2022-09-05 |
| 498 | Dream Analysis in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sleep is a fundamental period in life. In a previous work, the investigators have shown that COPD patients presented on the EEG figures found in patients with chronic pain: Alpha-Delta. The link between dyspnea and pain is very strong and this Alpha-Delta could, in these COPD patients, be the witness of nocturnal dyspnea. Although it is not possible in a non-awake patient to evaluate reliably the dyspnea, sleep offers us a window on the emotions and the feeling of the patient: Dreams. A few studies have shown the link between breathing and dreaming, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-09-05 |
| 499 | Deep Learning Diagnostic and Risk-stratification for Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease in Digital Lung Auscultations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), and chronic obstructive pulmonary disease (COPD) are severe, progressive, irreversibly incapacitating pulmonary disorders with modest response to therapeutic interventions and poor prognosis. Prompt and accurate diagnosis is important to enable patients to receive appropriate care at the earliest possible stage to delay disease progression and prolong survival. Artificial intelligence (AI)-assisted digital lung auscultation could constitute an alternative to conventional subjective operator-related auscultation to accurately and earlier diagnose these diseases. Moreover, lung ultrasound (LUS), a relevant gold standard for lung pathology, could also benefit from automation by deep learning. |
PIERRE-OLIVIER BRIDEVAUX; | 2022-09-02 |
| 500 | Triple Therapy Convenience By The Use of One or Multiple Inhalers and Digital Support in Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: TRICOLON is an investigator initiated, prospective, interventional, open-label, randomized, real-world, multi-centre, 3-arms study in the Netherlands. The primary objective is to investigate in COPD patients if single-inhaler triple therapy (SITT) is superior to multi-inhaler triple therapy (MITT) in terms of adherence to inhaled corticosteroids (ICS) therapy and to investigate if SITT with e-health support is superior to MITT and SITT without e-health support. |
FRANCISCUS GASTHUIS | 2022-09-01 |