Clinical Digest: Recent Clinical Trials on COVID-19
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to COVID-19. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on COVID-19
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Randomized, Controlled, Multicenter Phase I/II Study Comparing The Safety and Immunogenicity of A Booster Dose of An Intranasal COVID-19 Vaccine Expressing SARS-CoV-2 N/S Recombinant Proteins With A Booster Dose of COVID-19 MRNA Vaccine in Healthy Adults (MUCOBOOST) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase I/II trial in France evaluates safety and immunogenicity of a booster dose of an intranasal COVID-19 vaccine (LVT-001) versus a booster dose of a COVID-19 mRNA vaccine (Pfizer-BioNTech) in healthy adult volunteers. As a first-in-human trial, Phase I will assess the safety and immunogenicity of three escalating doses of the LVT-001 vaccine across 3 cohorts of 12 volunteers per dose level. Based on cumulative data collected up to Day 28 visit from the last included participant in the Phase I, … |
ANRS EMERGING INFECTIOUS DISEASES | 2025-05-01 |
| 2 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial – Effect of Hyperbaric Oxygen Therapy for The Treatment of Post COVID Condition (RECLAIM-HBOT) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The RECLAIM study platform will be used to explore whether the use of Hyperbaric Oxygen therapy (HBOT) improves the symptoms of post covid cognitive dysfunction. Hyperbaric oxygen therapy is a well-established medical treatment. HBOT promotes healing by delivering a high concentration of oxygen into the body. This high level of oxygen has a number of known benefits, such as growth of new blood vessels, as well as regulating immune and inflammation responses. It helps protect the brain and other nervous tissue from inflammation. HBOT may also have antiviral effects. Collectively, … |
RITA KATZNELSON; | 2025-05-01 |
| 3 | LC-REVITALIZE – A Long Covid Repurposed Drug Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Long-Covid (LC)-Revitalize clinical study is testing repurposed drug treatments for Long Covid, involving adult participants from Brazil, Canada, Italy, Uganda, Zambia, and the United States. To qualify, participants must have had Covid-19 and experienced Long Covid symptoms for at least three months. The main goal of the study is to determine whether the drug treatments can improve symptoms in five key areas: 1) fatigue, 2) breathing, 3) memory, thinking, and communication, 4) muscle and joint pain, and 5) circulation. A secondary goal is to assess changes in the body, such as reducing inflammation, … |
DOUGLAS D. FRASER; | 2025-05-01 |
| 4 | Physical Rehabilitation of Long COVID By Heat Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Although exercise intervention is a common strategy to restore functional capacity, it may not be feasible or enticing to many people with PASC. This clinical trial seeks to establish the tolerability and efficacy of at home lower-body heat therapy for improving functional capacity along with metabolic and vascular health in late-middle aged and older adults with PASC, also known as long COVID. |
GWENAEL LAYEC; | 2025-05-01 |
| 5 | From Inflammation Biomarkers to Remoddeling (FAPI PET/CT) Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: The diagnosis and pathogenesis of long COVID remains unknown. We have previously shown that \[68Ga\]FAPI Positron Emission Tomography-Computed Tomography (PET/CT) imaging shows potential for diagnosis and molecular understanding of this syndrome. We have previously shown that fibroblast activation protein (FAP) can be imaged in the lung, muscle and nasopharynx of long COVID patients (with dyspnea and fatigue). However, these preliminary data are derived from a selective group of patients with long COVID after critical COVID-19. We aim to explore the generalizability of these findings in patients with long COVID with dyspnea and fatigue, … |
J PILLAY; | 2025-05-01 |
| 6 | Effectiveness and Acceptability of The Unified Protocol for The Transdiagnostic Treatment of Emotional Disorders in People With Long COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Randomized Controlled Trial (RCT) aims to assess the effectiveness and acceptability of the Unified Protocol (UP) in an online group format for the treatment of emotional disorders in adults. Participants will be 90 adults (45 in the control group and 45 in the experimental group) with diagnosis of long COVID and comorbid emotional disorders. Participants will be recruited at Hospital Royo Villanova from Zaragoza, Spain. In this study it will be explored whether the changes obtained after the intervention in emotional disorders and cognitive complaints are maintained over 12 months. Additionally, … |
JORGE JAVIER OSMA LÓPEZ; | 2025-05-01 |
| 7 | Evaluating The Neuromodulatory Effect of Ketamine in Long COVID: A Pilot Study Targeting Fatigue and Neurocognitive Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Plain Language Summary: This study is a clinical trial to see if ketamine can help treat symptoms of Long COVID, especially fatigue and problems with thinking clearly (often called brain fog). Long COVID is a condition that affects people even after they have recovered from COVID-19, causing ongoing health issues like tiredness, memory problems, and difficulty concentrating. Right now, there are very few treatments available for these symptoms, … |
WILLIAM MICHAEL BRODE; | 2025-05-01 |
| 8 | Systems Biology of A MRNA Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Given Via Intradermal (ID) Injection Using Tropis Needle-Free Injection System (NFIS) or Intramuscular (IM) Injection Using Needle and Syringe PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if immune responses differ when the mRNA COVID-19 vaccine is given through different delivery methods, including a needle-free injection system, or via intramuscular injection using needle and syringe |
PHARMAJET | 2025-05-01 |
| 9 | Osteopathic Manipulative Therapy(OMT) Effects on Post-Acute Sequalae of COVID-19(PASC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is investigating the effects of using an Osteopathic Manipulative Therapy (OMT) treatment protocol that was shown to statistically improve smell in individuals suffering from Long-COVID olfactory (smell) dysfunction in a small single-blinded pilot trial conducted during 2021. The questions this study is trying to answer are: 1. Does this OMT protocol improve other non-smell related Long-COVID symptoms 2. Do 2 OMT treatments improve Long-COVID symptoms more than 1 OMT treatment Participants will: 1. Week 1: Take an digital survey regarding their Long-COVID symptoms undergo Long-COVID OMT treatment or a placebo treatment 2. Week 2: Take an digital survey regarding their Long-COVID symptoms then all will undergo Long-COVID OMT treatment 3. Week 3: Take an digital survey regarding their Long-COVID symptoms 4. Week 8: Take an digital survey regarding their Long-COVID symptoms |
MICHAEL STENTA; | 2025-05-01 |
| 10 | Routine Application of Point-of-care PCR Test to Identify and Direct Therapy for Acute Respiratory Infection in The Emergency Department (RAPID-ARIED) Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The RAPID-ARIED Trial is a pragmatic, single-centre, parallel group, open-label, randomised controlled trial to be conducted in the Accident and Emergency Department of Queen Mary Hospital in Hong Kong. The investigators aim to 1) to evaluate the clinical impact of the routine application of point-of-care polymerase chain reaction (PCR) testing for targeted respiratory pathogens in the emergency department (ED) for adult patients with acute respiratory infections (ARIs) on the hospital length of stay (LOS), antiviral and antibiotic use during influenza seasons or future waves of COVID-19; … |
LAM PUI KIN; | 2025-04-30 |
| 11 | Evaluation of The Diagnostic Performance of The DM-DIV (in Vitro Diagnostic Medical Device) TestNPass for The Diagnosis of SARS-CoV-2 Infection Using A Nasopharyngeal Sample PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic has created a major global health crisis that requires a rapid and effective response, particularly in the field of diagnostics. The first tests used, based on PCR (polymerase chain reaction) performed through a deep nasopharyngeal swab, have shown their limitations in controlling the epidemic. The current need is to develop new tests that are rapid, affordable and easy to use, and that can be used on a large scale in outpatient settings to reduce the burden on healthcare teams. In addition, … |
UNIVERSITY HOSPITAL GRENOBLE | 2025-04-30 |
| 12 | A Phase II, Multi-centre Open Label Study to Assess The Efficacy and Safety of Oral Apabetalone With Background Dapagliflozin in Subjects With Long -COVID-19 (Post-COVID-19 Conditions) and Type 2 Diabetes Mellitus (T2DM) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label, multicentre, phase II clinical trial that aims to assess the efficacy and safety of oral Apabetalone with background dapagliflozin for up to 12 weeks in T2DM patients with a history of probable or confirmed SARS-CoV-2 infection, with symptoms within 3 months from the onset of COVID-19 that last for at least 2 months and cannot be explained by an alternative diagnosis. |
RESVERLOGIX | 2025-04-15 |
| 13 | Phase 2 Study of S-892216 in Participants Infected With SARS-CoV-2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to investigate the antiviral effect of S-892216 in participants with coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. |
SHIONOGI | 2025-04-10 |
| 14 | Awake PROne Positioning in PatientS With Acute Hypoxemic Respiratory Failure in Germany – A Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia. Conclusive evidence for patients with AHRF without COVID-19 is still missing. We hypothesis that awake prone position in patients with AHRF is superior to standard supine/semi-recumbent position in terms of reducing the rate of tracheal intubation and/or all-cause death within 28 days after randomization. |
STEFAN KLUGE; | 2025-04-08 |
| 15 | Community-Academic Partnerships to Address COVID-19 Inequities Within African American Communities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the impact of an intervention to increase COVID-19 prevention behaviors, including COVID-19 testing. The intervention will be developed through a crowdsourcing contest. |
TIARNEY RITCHWOOD; | 2025-04-05 |
| 16 | Impact of Functional and Cognitive Rehabilitation, in Adults with Chronic Noncommunicable Diseases and Long Covid-19 , on Their Functional and Cognitive Capacity, Quality of Life, and The Evolution of Their Baseline Condition, in Bogotá D.C PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the impact of a functional and cognitive rehabilitation strategy compared to evidence-based informational messages, on functional capacity, cognitive abilities, quality of life, and disease progression in adults with chronic non-communicable diseases (NCDs) and Long Covid-19. Researchers will compare a structured rehabilitation program to informational support through evidence-based messages to determine if rehabilitation leads to better functional and cognitive outcomes in patients with Long Covid-19. Participants will be randomly assigned to one of two groups: 1. Functional and cognitive rehabilitation: Attending weekly in-person sessions for 8 weeks, … |
FUNDACIÓN CARDIOINFANTIL INSTITUTO DE CARDIOLOGÍA | 2025-04-01 |
| 17 | A Double-blind, Randomized Study to Evaluate The Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Long COVID is a condition where debilitating symptoms can persist for months after a COVID-19 infection. This study aims to evaluate the effects of NE3107 on several neurological symptoms reported in people with Long COVID including difficulty concentrating or remembering things (brain fog) and fatigue. Researchers will compare NE3107 to a placebo (a look-alike substance that contains no drug) to see if NE3107 works to treat neurocognitive and fatigue symptoms of long COVID. Participants will: * Take NE3107 or a placebo twice daily for 84 days * Visit the clinic 5 times for checkups and tests and have a follow up phone call |
BIOVIE | 2025-04-01 |
| 18 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial – Effect of Hi-OxSR for The Treatment of Post COVID Condition (RECLAIM-HiOxSR) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The RECLAIM study platform will be used to explore whether the use of the Hi-OxSR device improves the symptoms of post covid cognitive dysfunction. Carbon dioxide (CO2) has been proposed as a potential treatment for persistent immune activation as there is evidence that CO2 has antioxidant, anti-inflammatory, and anti-cytokine effects. We conducted a pilot study assessing the open label use of re-breathing CO2 (using Hi-OxSR) twice a day for 14 days, … |
ANGELA M CHEUNG; | 2025-04-01 |
| 19 | Community-based Behavioral Intervention to Increase COVID-19 and Influenza Vaccination for African American/ Black and Latino Persons: An Optimization Randomized Controlled Trial Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study responds to the need for community-engaged interventions to increase vaccine uptake among populations experiencing health disparities. We focus on COVID-19 and influenza vaccination, both of which now require annual vaccines. Among those at highest risk for morbidity, hospitalization, and mortality are African American/Black and Latino (ABBL) persons who are not up-to-date on these vaccinations. Only 20-28% of adult AABL persons are up-to-date on COVID-19 vaccination, compared to 31% of White persons, … |
NEW YORK UNIVERSITY | 2025-04-01 |
| 20 | Title Not in Corporate Clinical Trial Registry (CCTR) Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn about how well the yearly updates to the COVID-19 vaccine work in adults (age 18 years and above) with a healthy immune system (the body’s cells, … |
PFIZER | 2025-04-01 |
| 21 | Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have symptoms that last long after the active infection ends. This is called long COVID. Sometimes, long COVID can affect the nerves and cause problems with sleep, thinking, the senses, and movement. Researchers want to find out whether people with long COVID have retained inactive remnants of SARS-CoV-2 in their bodies. Objective: To collect tissue samples to see if people with long COVID have remnants of SARS-CoV-2 in their bodies. Eligibility: People 18 years or older who have recovered from COVID-19, … |
AVINDRA NATH; | 2025-03-27 |
| 22 | A Phase 2 Trial to Evaluate Safety and Immunogenicity of A Next-generation COVID-19 Vaccine Delivered By Inhaled Aerosol to Humans PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to study the safety of a new inhaled vaccine to prevent COVID infection and learn about the immune responses that are made in the lungs and the blood after vaccination. Participants will be randomized (like the toss of a coin) to receive the experimental vaccine or a placebo (a look-alike solution that contains no vaccine). To be in the study participants will have to have already had three doses of a messenger ribonucleic acid (mRNA) COVID vaccine and be generally healthy. Participants are given a single dose of the vaccine by breathing in a fine mist that goes directly into the lungs. During follow-up participants will: * visit the clinic for checkups and blood tests at 2, 4 and 8 weeks after vaccination * report their symptoms for 24 weeks after getting the vaccine. In some participants, the researchers will collect cells from the lung 4 weeks after vaccination (a test known as a bronchoscopy). |
FIONA SMAILL; | 2025-03-25 |
| 23 | Vale+ Tu Salud: Corner-Based Randomized Trial to Test A Latino Day Laborer Program Adapted to Prevent COVID 19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the cultural, socioeconomic, inter/personal and work-related factors that influence COVID 19 mitigation practices including social distancing, hand-washing and Personal protective equipment (PPE) use, to adapt, implement, and test Vale+Tú Salud in a cluster randomized trial to assess the extent to which LDL report increased adherence with COVID 19 mitigation practices 1 month post intervention and to promote Vale+Tú Salud just-in-time results and increase its capacity to rapidly disseminate findings among groups that serve LDL and other Latino immigrants. |
MARIA EUGENIA FERNANDEZ-ESQUER; | 2025-03-17 |
| 24 | A Phase 2, Randomized, Observer-blind, Active-control Study to Evaluate The Immunogenicity, Reactogenicity, and Safety of MRNA-1083 (Influenza and COVID-19) Vaccine in Adults ≥18 to <65 Years of Age PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the immunogenicity, reactogenicity, and safety, of mRNA-1083 multicomponent influenza and COVID-19 vaccine in adults ≥18 to \<65 years of age. |
MODERNATX | 2025-03-07 |
| 25 | Dissecting Human Immune Responses to Infection with Influenza or SARS-CoV-2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the virus-specific immune response in people who are symptomatic with confirmed influenza or COVID-19. We will study the immune response of people who have and who have not been vaccinated with the seasonal influenza and COVID-19 vaccines within the past year. All participants will have data collected and blood, saliva, and nasal swabs performed at five separate visits; 1) at study enrollment, 2) on study day 7, 3) on or between study days 10 to 28, 4) on study day 90, … |
PHILIP MUDD; | 2025-03-07 |
| 26 | A Randomized Controlled Basket Study for Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (RISE) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective, randomized controlled, basket trial. Patients diagnosed with Post-Acute Sequelae of SARS-CoV-2 Infection who meet the inclusion and exclusion criteria are recruited and divided into three symptom clusters: Inflammatory Cardiac involvement symptoms cluster, cough symptoms cluster and fatigue symptoms cluster. Each symptom cluster is randomly divided into an experimental group and a control group, Patients who do not accept treatment can be included in the observational cohort. Subjects in the experimental group receive immunomodulatory interventions plus conventional treatment, … |
WEN-HONG ZHANG; | 2025-03-01 |
| 27 | The Effects of Lactococcus Lactis JCM 5805 (LC-Plasma) Lactic Acid Bacteria on Immune Response and Reducing Symptoms of Upper Respiratory Infectious Disease in Australian Healthy Adults. Randomized Placebo-controlled Double-blind Parallel Group Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate the effects of LC-Plasma on the innate and acquired immune systems, including the activation of pDCs, which play a role in virus elimination, as well as to assess its efficacy in reducing clinical symptoms of upper respiratory infectious diseases in healthy adults. Researchers will compare LC-Plasma to placebo, participants will take a tablet containing LC-Plasma or placebo daily for 4 weeks. |
RDC CLINICAL PTY | 2025-03-01 |
| 28 | Optimising General Practice Long COVID Care – Feasibility Trial of A Pilot Educational Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial will evaluate the feasibility of a pilot educational intervention for GPs that aims to enhance care and care outcomes among patients with long COVID at six general practices in the Ireland East region. Our first objective is to conduct focus groups with key stakeholders (GPs, other health professionals, patients, families/carers) that will inform the contents of an education intervention. The second objective will be to implement this educational intervention, and the third objective will be to determine whether the intervention is feasible. Study outcomes will include: – … |
WALTER CULLEN; | 2025-03-01 |
| 29 | EFFICACY OF COLCHICINE IN IMPROVING CLINICAL OUTCOMES IN PATIENTS WITH MILD TO MODERATE COVID-19 PNEUMONIA IN LAHORE: A RANDOMIZED CONTROL TRIAL PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is for patients suffering from COVID-19 pneumonia (mild to moderate cases) ; especially in developing countries where expensive drugs are not available. Colchicine is an economically favourable anti inflammatory drug readily Used for gout patients but is being given experimentally in Covid 19 patients . Study has been designed in this way that drug has been given carefully to patients on which there will be no to minimum side effects . It is only to see beneficial effects if any present in Covid pneumonia patients which will be observed by clinical \& lab improvement. |
ZAEEMA KANWAL; | 2025-02-24 |
| 30 | Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Mental health symptoms, including cognitive impairment (brain fog), following COVID-19 are of great concern to Veterans. The investigators’ research seeks to advance understanding of the long-term effects of COVID-19 on neuropsychiatric and neurological functions, identifying clinically relevant biomarkers and directions for developing and testing therapeutic interventions. To accomplish these objectives the investigators are conducting a longitudinal study at two VA medical centers to: 1) assess and monitor cognitive function and psychiatric symptoms in Veterans post-COVID; 2) evaluate biomarkers of inflammation and signaling pathways associated with viral infection and neuropsychiatric function; … |
JENNIFER M LOFTIS; | 2025-02-20 |
| 31 | TELE-TOC: Telehealth Education Leveraging Electronic Transitions Of Care for COPD Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Transitions of Care (TOC) between hospital, ambulatory, and home settings for high-risk, frequently hospitalized adults with chronic diseases, such as chronic obstructive pulmonary disease (COPD) are complex, costly, and vulnerable to safety threats and poor health outcomes. One potential solution to address this gap in care is the Transitional Care Model (TCM), which utilizes a patient-centered approach with in-home interventions; since in-person in-home visits are costly, using innovative telehealth, such as virtual visits via teleconferencing may be just as effective with greater feasibility, scalability, and sustainability, … |
VALERIE G PRESS; | 2025-02-19 |
| 32 | Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue. This project seeks to analyze some blood components of people with long COVID, such as microRNAs and vitamin B12, in order to identify the body processes that changed after COVID-19 and thereby design better therapies and diagnostic methods focused on each of them. The hypothesis is that the expression of miR-21, … |
ALFONSO B. ALFARO; | 2025-02-18 |
| 33 | A PHASE 1/2 RANDOMIZED, DOUBLE-BLINDED STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF MODIFIED RNA VACCINE CANDIDATES AGAINST INFLUENZA AND COVID-19 IN HEALTHY INDIVIDUALS PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn about how the flu and COVID vaccines act when given alone or when mixed together. This study is seeking healthy participants aged 18 or older. All participants in this study will receive only 1 shot to their arm, either a flu or COVID vaccine, alone or mixed. Participants will take part in this study for about 6 months, and participants will need to visit the clinical study site at least 4 times. |
BIONTECH SE | 2025-02-10 |
| 34 | Phase II Proof-of-concept, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy and Safety of Plitidepsin in Adults with Post-COVID-19 Condition (PCC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to prove that plitidepsin could be an efficacious, safe, and well-tolerated therapy for PCC. To this end, we will perform a randomized, double-blind study comparing the clinical and laboratory benefits of plitidepsin vs. placebo in 90 subjects with moderate to severe functional disability. The study consists of an intervention period and a follow-up period, with a total of 135 +/-3 days approximately between both periods. During the intervention period, four treatment cycles will be administered, scheduled every 15 days (every 2 weeks), with intravenous (IV) infusion over three consecutive days. After completing the intervention period, … |
FUNDACIÓN FLS DE LUCHA CONTRA EL SIDA LAS ENFERMEDADES INFECCIOSAS Y LA PROMOCIÓN DE LA SALUD Y LA CIENCIA | 2025-02-07 |
| 35 | A Phase 3, Randomized, Observer-Blinded, Study to Compare The Safety and Immunogenicity of 3 Lots of SARS-CoV-2 RS Nanoparticle and Trivalent Hemagglutinin Nanoparticle Influenza Combination Vaccine With Matrix M™ Adjuvant in Participants ≥ 65 Years of Age Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of Phase 3 Study is Comparing the Safety and Immune Response of Three Batches of a COVID-19 and Flu Combination Vaccine in Seniors Aged 65+ |
NOVAVAX | 2025-02-01 |
| 36 | A Randomized Controlled Non-inferiority Trial of Placebo Versus Macrolide Antibiotics for Mycoplasma Pneumoniae Infection in Children with Community-acquired Pneumonia – The MYTHIC Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare a placebo (a look-alike substance that contains no active drug) with a commonly used antibiotic in children with Mycoplasma pneumoniae (a specific bacterium) induced community-acquired pneumonia. The main question it aims to answer is: Is antibiotic treatment needed in Mycoplasma pneumoniae (a specific bacterium) induced pneumonia? Participants will receive either a placebo or a antibiotic treatment and track their symptoms and vital signs until they are healthy. Researchers will then compare the length of symptoms between the placebo and the antibiotic group. |
CHRISTOPH BERGER; | 2025-01-28 |
| 37 | DETERMINING THE IMPACT OF MICROBIAL DYSBIOSIS ON IMMUNE AND BARRIER DYSFUNCTION IN LONG COVID PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The SARS-CoV-2 virus causes COVID-19, which ranges from mild initial symptoms to severe multi-organ dysfunction. While some patients recover to their baseline states, others develop a long COVID, or post-acute sequelae of SARS-CoV-2 (PASC) consisting of symptoms persisting \>2-6 months post-infection. PASC symptoms include post-exertional malaise, fatigue, and heart palpitations as well as incident GI disorders, cognitive dysfunction, and arthritis. Based on prevalence/incidence studies, … |
LAVANYA VISVABHARATHY; | 2025-01-21 |
| 38 | An Open Short-term Clinical Pilot Trial on Safety and Immunogenicity of Nasal COVID-19 Vaccine At Different Dose Levels and Administration Methods PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: COV2 is a nasal, investigational vaccine against COVID-19, based on a serotype 5 adenoviral vector producing the SARS-CoV-2 spike protein. In this trial, the primary comparison in terms of safety and immunogenicity will be between two different dose levels of COV2 booster vaccine (low, high), and two different administration methods (nasal drops, nasal spray). In addition, COV2 vaccine will also be evaluated in vaccine naive subjects. |
ROKOTE LABORATORIES FINLAND OY | 2025-01-21 |
| 39 | Assessing A Multicomponent Intervention to Improve Quality of Life in Individuals With Long COVID-19 (COVIDL/MIQoL): A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess the effectiveness of a multicomponent intervention in individuals with Long COVID. The main questions it aims to answer are: * Does the intervention increase quality of life, mental well-being, resilience, and physical condition in individuals with Long COVID? * Does the intervention decrease anxiety, depressed mood, and fatigue in individuals with Long COVID? The researchers will compare the multicomponent intervention with a control (non-intervention) group. Participants will: • Participate in a multicomponent intervention for 9 weeks (2 sessions each week, one of psycho-education and one of physical rehabilitation). |
MARIA LLISTOSELLA; | 2025-01-17 |
| 40 | Analysis of Single Respiratory Viral Infections Versus Co-infections in The Post-pandemic Era: Prevalence and ICU Needs in Hospitalized Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of our study is to investigate the prevalence of viral respiratory infections in inpatients following the end of the pandemic. Additionally, the prevalence of patients co-infected with multiple viruses simultaneously will be assessed. In the secondary part of the study, the development of respiratory tract infections, the need for intensive care, and mortality rates within seven days will also be evaluated, and risk factors for patients with a more severe clinical course will be statistically calculated. |
ÖZLEM GÜLER; | 2025-01-12 |
| 41 | The Trial Uses Medicinal Herbs to Direct T Cells to Engulf The COVID-19 Virus and Protect The Organs Well PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The human immune system is designed to protect individuals from external sources of infection and internal cell mutation. It works effectively and efficiently until inflammation disturbs its functioning. Once compromised by inflammation, the immune system loses its capacity to recognize antigens and dependably defend the body against disease and illness. When COVID-19 invades humans, it causes an immune-storm (cytokine-storm) that can directly damage the organ(s), leading to death. The virus is an antigen – a trigger – but it is not the actual reason that causes organ failure and death; instead, … |
WANZHU HOU; | 2025-01-01 |
| 42 | Evaluation of Concordance Between An Innovative Test on Exhaled Air (eBAM-CoV) and RT-PCR to Detect SARS-CoV-2 in Symptomatic Patients or Closed Contacts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: During the COVID-19 pandemic, testing primarily relied on the use of nasopharyngeal swabs to detect the SARS-CoV-2 virus, responsible for the disease. However, this technique has several limitations, including the variable quality of swabs, its invasive nature, and arbitrariness in the choice of the number of cycles. Furthermore, it does not allow for the detection of viral proteins. To overcome these limitations, researchers developed the eBAM-CoV test, patented for the detection of viral proteins in the exhaled air of COVID-19 patients. This portable device provides an immediate assessment of the viral load with both quantitative and qualitative results, … |
CENTRE HOSPITALIER UNIVERSITAIRE DE NĪMES | 2025-01-01 |
| 43 | Prospective Clinical Evaluation of COVID/Flu Detect™ Rapid Self-Test in Symptomatic Subjects for Non-Prescription Over-the-Counter (OTC) Use PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate the performance of the COVID/Flu Detect™ Rapid Self-Test when used in a home-like setting by lay users. The COVID/Flu Detect™ Rapid Self-Test is an investigational device intended for the qualitative detection and differentiation of SARS-CoV-2, influenza A, and influenza B protein antigens in nasal swab samples. Participants who are aged two (2) years and older and have symptoms of respiratory illness consistent with SARS-CoV-2 and influenza infection may be enrolled. Participants will use the COVID/Flu Detect™ Rapid Self-Test to self-collect, self-test, … |
INBIOS INTERNATIONAL | 2024-12-26 |
| 44 | A Phase 1 Study to Assess The Effect of Carbamazepine on The Pharmacokinetics of S-892216 in Healthy Adult Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to investigate the effect of multiple-dose administration of carbamazepine on the pharmacokinetics of S-892216 in healthy adults. |
SHIONOGI | 2024-12-17 |
| 45 | A Non-interventional, Prospective, Cross-sectional Study of The Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associated with The Post-acute Phase of The Infection By Sars-Cov-2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: More than 660 million cases of COVID-19 have been reported worldwide, with 183 million cases in the EU alone. In several people, after recovery, the effects of the first waves of COVID-19 persisted beyond the acute phase and increased the risk of chronic multiorgan symptoms and disease. Up to 70% of people affected by COVID-19 showed reduced organ function even four months or more after COVID-19 diagnosis. Such a functional decline is associated with an increased risk of the development of non-communicable diseases (NCDs). Thus, there is an essential need for a better knowledge, tools, … |
HELLENIC INSTITUTE FOR THE STUDY OF SEPSIS | 2024-12-10 |
| 46 | A Randomized, Observer-Blinded, Active-Controlled Study to Evaluate The Safety and Immunogenicity of A COVID-19 Influenza Combination Nanoparticle Vaccine and A Standalone Trivalent Nanoparticle Influenza Hemagglutinin Vaccine in Participants ≥ 65 Years of Age PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a medical study where participants will be randomly assigned to receive either a new combination vaccine that protects against both COVID-19 and the flu, or a standard flu vaccine. The researchers conducting the study won’t know which vaccine each participant receives, ensuring their observations are unbiased. This study compares the new combination vaccine to an already available flu vaccine to see how well it works. It’s a large-scale, final-stage study designed to thoroughly check how well the vaccines trigger an immune response (immunogenicity) and how safe they are. |
NOVAVAX | 2024-12-09 |
| 47 | AN INTERVENTIONAL EFFICACY AND SAFETY, PHASE 3, DOUBLE-BLIND, 2-ARM STUDY TO INVESTIGATE ORALLY ADMINISTERED IBUZATRELVIR COMPARED WITH PLACEBO IN NON-HOSPITALIZED SYMPTOMATIC ADULT AND ADOLESCENT PARTICIPANTS WITH COVID-19 WHO ARE AT HIGH RISK OF PROGRESSING TO SEVERE ILLNESS PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate whether ibuzatrelvir is effective and safe in adults and adolescents with COVID-19 who do not need to be in the hospital but who are at high risk for progression to severe disease. Eligible participants will be randomly assigned (by chance) to receive ibuzatrelvir or matching placebo orally for 5 days. Co-administration of locally available standard of care is allowed. The total duration of the study is around 6 months. |
PFIZER | 2024-12-08 |
| 48 | A Phase 2b, Randomized, Double-blind, Active-controlled Study of Single Dose CVXGA (CVXGA50) Intranasal COVID-19 Vaccine in Adults PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to assess the safety and relative efficacy of CVXGA (CVXGA50), a KP.2 containing vaccine, compared to COMIRNATY® (COVID-19 Vaccine, mRNA; 2024-2025 Formula), a currently approved COVID-19 vaccine in the prevention of symptomatic, RT-PCR-confirmed SARS-CoV-2 infection. The trial will enroll up to 10016 healthy participants. |
HONG JIN; | 2024-12-05 |
| 49 | A Phase 3, Randomized, Placebo-Controlled, Double-Blind Clinical Study to Evaluate The Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adults With COVID-19 at High Risk for Disease Progression PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Researchers are looking for other ways to prevent severe illness from COVID-19. COVID-19 is a virus that most often causes mild flu or cold-like symptoms. However, people with certain health conditions or other factors have a high risk (chance) of getting severely ill from COVID-19, which can require a hospital stay or lead to death. Some people who are high risk for severe illness may be unable to take certain treatments for COVID-19 because they are not available to them, … |
MERCK SHARP & DOHME | 2024-12-02 |
| 50 | Characterization of The IFN-I Response in Subjects Who Experienced Severe or Mild Forms of COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Type I interferon (IFN-I) production is triggered by the detection of viral molecules, such as strands of viral RNA or DNA, by receptors known as PRRs (Pattern Recognition Receptors) present on many cell types. These interferons are secreted in minimal concentrations but can activate neighboring cells to secrete over 700 proteins with antiviral properties (inhibition of viral replication, destabilization of viral membranes, etc.). Thus, the IFN-I response serves as the immune system’s first line of defense during a viral infection. Very early in the COVID-19 pandemic, several research teams, including ours, … |
JEAN-CHRISTOPHE RICHARD; | 2024-12-02 |
| 51 | Thymalfasin (Thymosin Alpha 1; Ta1) As An Enhancer of Vaccine Response Among Older Adults Receiving Booster Doses of COVID-19 Vaccine PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this research is to learn more about ZADAXIN® (trade name; thymalfasin generic; Ta1 for short) and determine if Ta1 has any benefit in increasing the immune response to the COVID-19 vaccine. Ta1 has been shown to stimulate the immune system to fight infections. This research study will test the safety and possible harms of Ta1 when it is given to people at different dose levels before COVID-19 vaccination. |
THE METHODIST HOSPITAL RESEARCH INSTITUTE | 2024-12-02 |
| 52 | The Effects of Qi-gong on Physiology and Quality of Life in Patients with Post-acute Sequelae of Covid-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine whether Qi-Gong can improve physiological function and quality of life (QoL) in individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Study Objectives: To assess whether Qi-Gong improves physiological function in individuals with PASC. To evaluate whether Qi-Gong enhances quality of life in individuals with PASC. Study Design: If a comparison group is included, researchers will compare Qi-Gong with standard care to assess its effectiveness. Participant Involvement: Practice Qi-Gong three times per week for three months. Record physiological data monthly. |
MEI-HUA WANG; | 2024-12-02 |
| 53 | Virtual Intervention and Direct Assessment (VIDA) of Social Determinants of Health in Southern Minnesota Latino Communities After Coronavirus Disease 2019 (COVID-19): A Pilot Study. The VIDA After COVID Study Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to objectively identify and address social determinants of health (SDOH) priorities and barriers in Latino patients who survived or are vulnerable to COVID-19, and to understand the consequences of COVID-19 survivorship in local Latino communities. |
ALICE GALLO DE MORAES; | 2024-12-01 |
| 54 | Estimated Vaccine Effectiveness and Durability of Pfizer/BioNTech 2024-2025 COVID-19 Vaccine Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a retrospective case control analysis on the real-world effectiveness of the Pfizer-BioNTech BNT162b2 vaccine (2024-2025 formulation) against symptomatic SARS-CoV-2 infection among CVS MinuteClinic patients testing for SARS-CoV-2, across different age groups, during periods of various variant circulation, and by months since receipt of vaccine dose. |
PFIZER | 2024-11-25 |
| 55 | A Phase 1/2, Parallel, Randomized, Modified Double-blind, Multi-arm Study to Assess The Safety and Immunogenicity of A Combination Vaccine Comprised of Different Recombinant Spike Antigen Levels of A Matrix-M Adjuvanted Recombinant COVID-19 Vaccine and High-dose Inactivated Influenza Vaccine in Adult Participants 50 Years of Age and Older PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Study VBT00001 is planned to be a Phase 1/2, randomized, modified double-blind, active-controlled, multi-center study to be conducted in approximately 980 adults aged 50 years and older in the United States. The purpose of the study is to assess the safety and immunogenicity of IIV-HD (high-dose inactivated influenza vaccine) + rC19 (adjuvanted recombinant COVID-19 vaccine) vaccine comprised of IIV-HD combined with different recombinant Spike (rS) antigen levels of rC19 compared to IIV-HD alone, rC19 (dose 1) alone, and IIV-HD and rC19 (dose 1) (coadministered in opposite arms). Placebo will be coadministered in the IIV-HD alone, rC19 (dose 1) alone, … |
SANOFI | 2024-11-19 |
| 56 | A Phase 1/2, Parallel, Randomized, Modified Double-blind, Multi-arm Study to Assess The Safety and Immunogenicity of A Combination Vaccine Comprised of Different Recombinant Spike Antigen Levels of A Matrix-M Adjuvanted Recombinant COVID-19 Vaccine and Recombinant Influenza Vaccine in Adult Participants 50 Years of Age and Older PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Study VBT00002 is planned to be a Phase 1/2, randomized, modified double-blind, active-controlled, multi-center study to be conducted in approximately 980 adults aged 50 years and older in the United States. The purpose of the study is to assess the safety and immunogenicity of recombinant influenza vaccine (RIV) + adjuvanted recombinant COVID-19 vaccine (rC19) vaccine comprised of RIV combined with different recombinant Spike (rS) antigen levels of rC19 compared to RIV alone, rC19 (dose 1) alone, and RIV and rC19 (dose 1) (coadministered in opposite arms). Placebo will be coadministered in the RIV alone, rC19 (dose 1) alone, … |
SANOFI | 2024-11-18 |
| 57 | Covid-19 Data Analyses in Brazil. Retrospective Study Using An Open Data Plataform (DataSUS) to Describe and Analyze Patient Characteristics and Covid-19 Outcomes in Brazil PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This descriptive study aims to describe the Brazilian scenario of patients hospitalized due to COVID-19 and to analyze the impact of COVID-19 on the Brazilian public health system. Data will be extracted from the largest secondary database of the Brazilian public health system, DATASUS (Departamento de Informática do Sistema Único de Saúde), responsible for collecting, processing, analyzing and disseminating health information and statistics in the country. The analysis, performed only on patients hospitalized during the hospitalization episode, will also evaluate the impact of vaccination against COVID-19 on the immunocompromised population compared to the general population. |
ASTRAZENECA | 2024-11-12 |
| 58 | Improving Health Status in COVID-19 Long-Hauler Through An Activity Coaching Programme: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized clinical trial investigates the effects of a distance physical activity coaching program on the health of COVID-19 long-hauler. The study evaluates the impact of individualized coaching interventions to improve participants’ physical activity and quality of life. |
MARIE CARMEN VALENZA; | 2024-11-11 |
| 59 | A Non-interventional, Prospective, Cross-sectional Study of Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infection By Sars-Cov-2 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Pneumonia, which can be acquired in the community (including influenza and COVID-19), is a leading cause of mortality. The risk of severe cardiovascular diseases events (stroke, myocardial infarction, pulmonary embolism) increases after infections, but causal mechanisms are not understood yet. There is an essential need for improved understanding of the relationship between pneumonia and cardiovascular diseases and early identification of patients at risk of cardiovascular events to develop tailored therapies. The overall concept underpinning Homi-lung is to investigate the time course of host-microbiome interactions during \&amp; after pneumonia to i) understand the causal relationship between trained immunity, … |
HELLENIC INSTITUTE FOR THE STUDY OF SEPSIS | 2024-11-08 |
| 60 | Virus-induced Immunosuppression Via Infection of Hematopoietic Progenitors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We propose to demonstrate that HIV-1 and SARS-CoV-2 are capable of targeting long-lived HSPC with self-renewal capacities. These progenitors, thus transformed into host cells, can give rise to a durable source of infected cells with an impact on hematopoiesis. |
CLAUDE CAPRON; | 2024-10-25 |
| 61 | Evaluation of A Multilevel Intervention on Adult COVID-19 and Influenza Vaccination Rate PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will test two tactics to improve uptake of two vaccines in adults. The vaccines prevent COVID-19 and influenza. Both are common and harmful. Most adults do not get either vaccine. This is despite strong recommendations that all adults get both vaccines. The study will involve adult patients at eight Mayo Clinic primary care practices in Rochester and Kasson. The study will test the two tactics together. Four clinics will get the two tactics. The other four clinics will not. The study will randomly assign the two tactics to the clinics. One tactic is to send a letter by US mail to the patient. The letter will state strong recommendations on getting both vaccines now. It will tell patients how to get the vaccines now. The second tactic is to send monthly emails to clinicians. It will remind them to use every visit to vaccinate patients against COVID-19 and influenza. The study will compare the uptake of the two vaccines after six months in the clinics with and without the two tactics. |
LILA J. RUTTEN; | 2024-10-21 |
| 62 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post-COVID-19 symptom burden, and biomarkers of inflammation and viral measures, in participants with Long COVID. |
WES ELY; | 2024-10-21 |
| 63 | A Longitudinal Assessment of Serology and Effectiveness to Determine COVID-19 Vaccine Correlates of Risk (CoR) and Correlates of Protection (CoP) in A Heterogeneous US Population Through Use of Decentralized Sites and Approaches for Data/specimen Collection PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite the availability of vaccines, there remains a need to identify specific immune responses that correlate with protection against SARS-CoV-2 infection. Additionally, the operational capability of retail pharmacy infrastructure to collect longitudinal data and biological samples needs to be assessed. This study aims to fill these gaps by determining correlates of protection (CoP), assessing the infrastructure’s capability, and examining demographic and geographic differences in participation. |
BIOMEDICAL ADVANCED RESEARCH AND DEVELOPMENT AUTHORITY | 2024-10-19 |
| 64 | Clinical Validation of The Aptitude Medical Systems Metrix COVID-19 Test for Detection of SARS-CoV-2 in Point-of-Care and At-Home (OTC)/Non-Laboratory Settings PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The Metrix COVID Test will be evaluated for use in Point-of-Care and Non-Laboratory settings in a home testing environment utilizing the clinical study design described herein. The study will take place in simulated home environments which will be set up within or near active clinical settings (e.g., … |
APTITUDE MEDICAL SYSTEMS | 2024-10-17 |
| 65 | Pilot Study on The Feasibility of An RCT: Evaluating Periodic Fasting As A Treatment Strategy for Long Covid in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Long COVID, characterized by persistent symptoms following acute COVID-19 infection, has emerged as a significant public health concern. Symptoms range from fatigue, cognitive impairments, to respiratory difficulties, affecting patients' quality of life. Dietary interventions, particularly fasting, have historically been used to modulate immune responses and improve health outcomes in various conditions. The Buchinger-Wilhelmi method represents a structured and medically supervised fasting approach. Given the inflammatory nature of long COVID, fasting may offer therapeutic benefits by modulating the immune response, enhancing cellular repair mechanisms, … |
JOCHEN SCHNEIDER; | 2024-10-15 |
| 66 | A Phase 3 Open-Label, Single-Arm Study to Evaluate The Safety and Immunogenicity of A JN.1 Subvariant SARS CoV-2 RS Vaccine PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study aims to investigate the safety and immunogenicity of the Novavax JN.1 subvariant vaccine SARS-CoV-2 rS adjuvanted with Matrix-M (NVX CoV2705) in previously vaccinated adults. A descriptive comparison will be made with participants who received the prior authorized vaccine NVX-CoV2601 in an earlier study (2019nCoV-313). |
NOVAVAX | 2024-10-14 |
| 67 | Korean Post Marketing Surveillance for Comirnaty Injection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to identify any problems and questions with respect to the safety of Comirnaty Injection (Bretovameran) during the post-marketing period. |
PFIZER | 2024-10-11 |
| 68 | A Phase 2b, Double-Blind, Multi-Center, Randomized, Comparator-Controlled Trial to Determine The Relative Efficacy, Safety, and Immunogenicity of The Investigational Oral SARS-CoV-2 Vaccine Tablet (VXA-CoV2-3.1) Against Currently Approved/Authorized MRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to determine the relative efficacy of the investigational oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine tablet VXA-CoV2-3.1 compared to a currently recommended vaccine for the prevention of symptomatic Coronavirus Disease 2019 (COVID-19). |
VAXART | 2024-10-08 |
| 69 | Text4Vax: Understanding The Effectiveness and Implementation of Text Message Reminders for Pediatric COVID-19 and Influenza Vaccines 2024-2025 Season PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This multi-site study assesses the impact of text message reminders on the receipt of COVID-19 and influenza text message reminders takes place primarily in practices from the American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) network. |
MELISSA STOCKWELL; | 2024-10-01 |
| 70 | EbolaCov: A Phase IV, Single-centre, Single-blinded, Randomized Controlled Trial to Assess Safety and Immunogenicity of RVSVΔG-ZEBOV-GP Vaccination When Dosed Concurrent With MRNA COVID-19 Vaccine Booster Doses in Healthy African Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Concurrent vaccination scheduling for key target populations in Rwanda, such as healthcare workers, may confer significant advantages in the provision of vaccine coverage to several infectious diseases. This is a phase IV vaccine trial that looks to establish if two licenced vaccines, the rVSVΔG-ZEBOV-GP vaccine for protection against Ebola virus and messenger ribonucleic acid (mRNA) COVID vaccine for protection against SARS-CoV-2 virus, given concurrently to self selected healthy adult volunteers confers an acceptable safety profile and immunogenicity response. |
CHRISTOPHER GREEN; | 2024-10-01 |
| 71 | A Multi-Site Clinical Evaluation of The LIAISON NES FLU A/B, RSV & COVID-19 Assay in Symptomatic Patients PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The DiaSorin Molecular LIAISON® NES FLU A/B, RSV & COVID-19 real-time polymerase chain reaction (RT-PCR) assay is intended for use on the DiaSorin LIAISON® NES instrument for the in-vitro qualitative detection and differentiation of nucleic acid from influenza A, influenza B, RSV and SARS-CoV-2 virus from dry nasal swabs (NS) from human patients with signs and symptoms during the acute phase of respiratory tract infection in conjunction with clinical and epidemiological risk factors. The LIAISON® NES FLU A/B, RSV & COVID-19 assay is intended for use as an aid in the differential diagnosis of influenza A, influenza B, … |
DIASORIN MOLECULAR | 2024-09-30 |
| 72 | Comparison of High Vs Standard Dose Influenza Vaccines in Pediatric Solid Organ Transplant Recipients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients. However, these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV). Recent studies have investigated two strategies to overcome poor immune responses in SOT recipients: (1) administration of high-dose (HD)-IIV compared to SD-IIV and (2) two doses of SD-IIV compared to one dose of SD-IIV in the same influenza season. One study compared HD-IIV vs. SD-IIV in adult SOT recipients and noted that HD-IIV was safe and more immunogenic; however, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2024-09-26 |
| 73 | Impact of Reactogenicity of The 2024-2025 COVID-19 Vaccines on Health Care Workers and First Responders in The United States PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To assess the impact of reactogenicity among health care workers and first responders receiving an updated 2024-25 Novavax COVID-19 vaccine as compared with those receiving an updated 2024-25 Pfizer-BioNTech mRNA COVID-19 vaccine |
SARANG K YOON; | 2024-09-20 |
| 74 | Investigation of COVID-19 Post-acute Sequelae in Patients from Hvidovre Hospitals Catchment Area, and in A Register of The Danish Population 2000-2026 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Since the first SARS-CoV-2 cases in 2019, over 660 million COVID-19 cases have been reported globally, including 183 million in the EU. Up to 70% of those infected experience reduced organ function four months or more after a COVID-19 diagnosis, potentially increasing the risk of non-communicable diseases (NCDs). The post-acute phase (PAP) after COVID-19 (four months or more after the acute phase) can lead to impaired function in various organ systems, with a focus on the lungs, cardiovascular system, and kidneys. These three NCDs collectively impose a significant burden on individuals and society. Urgently, … |
OVE ANDERSEN; | 2024-09-10 |
| 75 | A Phase 3b/4, Open-label Study to Assess The Immunogenicity of MRNA COVID-19 Variant-containing Vaccine Formulations in Previously Vaccinated Adults Aged ≥18 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the immunogenicity of mRNA COVID-19 variant-containing vaccine formulations against the vaccine matched variants and newly emerged variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in previously vaccinated adults. |
MODERNATX | 2024-09-09 |
| 76 | Identification of COVID-19 Infection From Measurement of Exhaled Breath PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The type and number of chemicals in exhaled breath are different in people with infection as compared to those without infection. In this study, the breath of people with and without COVID infection will be measured. Changes in the amount and type of chemicals in breath will be used to determine if an individual does or does not have COVID infection. If the measurements of breath are a reliable measure of COVID infection, this device may be used to rapidly screen people who are attending large public events (for example, … |
GEORGE DIAZ; | 2024-08-19 |
| 77 | Cognitive Muscular Therapy for Patients With Long-COVID (Post COVID-19) and Breathing Pattern Disorder PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to test a treatment known as Cognitive Muscular Therapy (CMT) for reducing breathlessness and improving autonomic function in patients with long-COVID. |
UNIVERSITY OF SALFORD | 2024-08-01 |
| 78 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple interventions and allows comparative analysis across the interventions. For example, objectives, measures, and endpoints are generalized in the platform protocol, but intervention-specific features are detailed in separate appendices. This platform protocol is a prospective, multi-center, multi-arm, … |
PARTHASARATHY SAIRAM; | 2024-07-31 |
| 79 | The Impact of Education on The Rehabilitation of Patients Hospitalized Due to Pneumonia With Confirmed COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The planned research will enable the assessment of rehabilitation’s effects using two pulmonary rehabilitation models: conventional and supplemented with an education program for patients hospitalized due to pneumonia with confirmed COVID-19. |
RENATA BORYS; | 2024-07-26 |
| 80 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management programs and treatment plans if results achieve key study outcomes. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating interventions to address and improve exercise intolerance and post-exertional malaise (PEM) as manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). The focus of this protocol is to assess interventions that can improve exercise capacity, daily activities tolerance, … |
NATHAN ERDMANN; | 2024-07-17 |
| 81 | Effectiveness of Combined Pulmonary Rehabilitation and Progressive Muscle Relaxation on Long-term COVID-19 Symptoms: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study aimed to evaluate the effectiveness of a 21-day program combining pulmonary rehabilitation (PR) with progressive muscle relaxation (PMR) in patients experiencing long-term symptoms of COVID-19. Participants with persistent symptoms will be randomly assigned to either a PR group or a PR combined with PMR group. The PR program includes aerobic exercises, strength training, and breathing exercises, while the PMR sessions involve systematic muscle tensing and relaxation techniques. We will measure outcomes such as lung function, exercise capacity, anxiety, depression, and sleep quality using validated questionnaires and clinical tests. |
ALEXANDRU CRISAN; | 2024-07-15 |
| 82 | Single-center, Randomized, Double-blind, Placebo-controlled Phase I/II Clinical Trial to Evaluate The Safety, Tolerability and Immunogenicity of Recombinant COVID-19 Vaccine (Sf9 Cells) in Healthy People Aged 6-17 Years Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase Ⅰ/Ⅱ, single-center, randomized, double-blind, placebo-controlled study, to evaluate the safety, tolerability and immunogenicity of the recombinant COVID-19 vaccine (Sf9 cells) in the subjects from healthy aged 6-17 years with immunization procedures 0, 21, 42 days and doses (10μg/20μg/40μg). |
FENGCAI ZHU; | 2024-07-01 |
| 83 | Applying Artificial Intelligence to Identify Subphenotypes of Acute Kidney Injury in Mexican Patients With Severe COVID-19 PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study was to identify subphenotypes of acute kidney injury patients with COVID-19, and the investigators analyzed their impact on mortality. The study included demographic and clinical variables of the participants. The implementation of Machine Learning algorithms and Artificial Intelligence methods are used, and some specific implementations were designed for the analysis, where each group was characterized by traditional statistical methods. |
ELIZABETH SANTIAGO DEL ANGEL; | 2024-06-18 |
| 84 | Use of Artificial Intelligence (AI) for The Prediction of Clinical Outcomes Such As Death and Complications in Patients Hospitalized for COVID Pneumonia During The 4 Pandemic Waves at The ASST of Lecco PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Predictive models can be applied in different areas, during the emergency of the COVID-19 pandemic, in fact, they have proven important in supporting health systems in planning strategic decisions and in formulating health policies for the containment of the disease. The Covid-19 pandemic, in particular, has represented a real challenge for our healthcare system. In Italy, it was divided into four main waves, … |
STEFANIA PICONI; | 2024-06-01 |
| 85 | Piloting A Telehealth Deliverable Self-Management and Cognitive Training Program (HOBSCOTCH, HOme Based Self-Management and COgnitive Training CHanges Lives) for People With Post Acute COVID-19 Syndrome (PACS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, HOBSCOTCH, for people with Post Acute Covid Syndrome (PACS). The main questions it aims to answer are: Can the current HOBSCOTCH program be adapted for people with PACS? Will people with PACS experience improved quality of life similar to that found in people with epilepsy after participating in the HOBSCOTCH program? Participants will be asked to: – attend nine, one-hour virtual (online and/or by telephone) HOBSCOTCH-PACS sessions with a one-on-one certified HOBSCOTCH-PACS coach – … |
ELAINE T. KIRIAKOPOULOS; | 2024-05-14 |
| 86 | A Multi-Site Clinical Evaluation of The LIAISON NES FLU A/B, RSV, & COVID-19 and LIAISON PLEX Respiratory (RSP) Flex Assays in Symptomatic Patients in Australia PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To establish the relative accuracy of the LIAISON® NES Flu A/B, RSV & COVID-19 assay for viral nucleic acid targets from professionally collected or patient self-collected dry nasal (NS) swabs and to establish the relative accuracy of the LIAISON PLEX® RSP Flex assay from NS and nasopharyngeal swabs (NPS) in applicable transport media from human patients exhibiting clinical signs and symptoms of a respiratory tract infection. |
JANET FARHANG; | 2024-05-06 |
| 87 | A Systematic Review of COVID-19’s Impact on Pregnancy Outcomes Related Papers Related Patents Related Grants Related Experts View Highlight: This systematic review aims to evaluate the impact of COVID-19 on pregnancy outcomes. It synthesizes data from various studies to provide insights into the effects of the virus on maternal and fetal health. The review focuses on key outcomes such as preterm birth, maternal complications, and neonatal health, utilizing comprehensive literature from peer-reviewed journals. By analyzing existing studies, we aim to identify trends and gaps in research regarding COVID-19 and pregnancy. This review is intended to inform healthcare providers and pregnant individuals about potential risks and considerations during the pandemic. |
HAMIDREZA KOUHPAYEH; | 2024-05-03 |
| 88 | A Binded, Randomised, Controlled Cross-over Trial to Assess The Safety and Efficacy of Mucosal Covid-19 and Influenza Vaccines PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the current study is to assess the effectiveness of protein-based COVID-19 or influenza vaccines when given individually or together via oral/ sublingual mucosal route instead of intramuscular delivery. The comparator will be a seasonal influenza vaccine which will also be administered with Advax-CpG adjuvant via the oral route. This study will use a cross-over design and everyone in the study will over a space of about 4 months receive both the COVID-19 and influenza vaccines. |
DIMITAR SAJKOV; | 2024-04-21 |
| 89 | Effects of Non-invasive Neuromodulation on Post-COVID-19 Syndrome: Multicenter Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to analyse whether there is an advantage in adding low-intensity electrical stimulations to the vagus nerve with electrodes in the outer ear to control pain and fatigue in people with primary chronic pain, … |
FEDERAL UNIVERSITY OF ABC | 2024-04-21 |
| 90 | Investigation of The Effect of Virtual Reality on Fatigue, Functional Capacity and Respiratory Function in Patients With Long Covid-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: SARS-CoV-2 was first detected in Wuhan, Hubei Province, China, in late 2019. It is a highly contagious virus that has been reported to occur in humans and is said to cause pneumonia. Covid-19 infection is transmitted through droplets during coughing and sneezing and through contact with the mouth, nose or eyes after contaminated hands. The most obvious symptoms of Covid-19 symptoms include cough, dyspnea and fever. Covid-19, which can also be seen asymptomatic, is in intensive care it may be severe enough to require hospitalization, cause multiple organ failure and even death it could be. Musculoskeletal symptoms such as fatigue, … |
YASEMIN BURAN ÇIRAK; | 2024-04-20 |
| 91 | Investigating The Effectiveness of Vimida, A Digital Intervention for People Suffering From Post-viral Chronic Fatigue After COVID-19 Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized controlled trial (RCT) with 160 patients suffering from fatigue after COVID-19 infection aims to investigate the effectiveness of the unguided digital therapeutic vimida for reducing post-COVID-19 fatigue. Inclusion criteria are: male, female or non-binary, age ≥18 years, diagnosis of post-COVID-19 fatigue, ≥3 months since the last infection with COVID-19, fatigue severity score (cut-off) of ≥ 16 on the Chalder Fatigue Scale (CFQ-11), consent to participation, … |
JOHANNA SCHRÖDER; | 2024-04-15 |
| 92 | Analysis of Laboratory Markers for Severe COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The course of coronavirus infection was often severe and required hospitalization of patients in the intensive care unit. The new SARS-Cov-2 has been poor studied, so relatively reliable markers are needed to effectively monitor patients and predict complications and outcome. Taking into account the known mechanisms of pathogenesis, the biochemical markers as ferritin, procalcitonin, C-reactive protein and D-dimer were chosen for this purpose. Patients were divided according to the degree of pulmonary infiltration. We hypothesized that the markers would correlate with dynamics, complications, and outcomes. |
KARAGANDA MEDICAL UNIVERSITY | 2024-04-10 |
| 93 | Randomized, Observer-Blind, Active-Controlled, Clinical Trial to Assess The Immunogenicity of An Investigational MRNA-1273.815 COVID-19 Vaccine in Previously Vaccinated Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate immune responses of an Investigational mRNA-1273.815 vaccine against the Omicron subvariant strain (XBB.1.5) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). |
MODERNATX | 2024-04-08 |
| 94 | Optimal Timing for Tracheostomy in Invasively Mechanically Ventilated COVID-19 Patients PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Tracheostomy is a medical procedure performed on the front of a persons neck. It is used to create a connection between the persons trachea and a mechanical ventilator instead of using a tube going through the mouth into the trachea, oral intubation. Living with a tracheostomy tube is less stressful compared to oral intubation and facilitate being awake and the start of training on spontaneous ventilation in mechanically ventilated patients. Studies of the timing of tracheostomy are either severely affected by methodological bias of to small to determine an effect. Thus, … |
BJÖRN AHLSTRÖM; | 2024-04-02 |
| 95 | A Randomized, Double-blind, Placebo-controlled, Multicenter Phase II Clinical Study to Evaluate The Efficacy, Safety, and Pharmacokinetics of SHEN211 Tablets in The Treatment of Patients With Mild and Moderate Novel Coronavirus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized, double-blind, placebo-controlled, multicenter phase II clinical study of SHEN211 tablets |
HONGZHOU LU; | 2024-04-01 |
| 96 | Relevance of The Multiplex PCR Approach for Severe Respiratory Infections of Patients Hospitalized – Including An Intensive Care Unit, During The COVID-19 Pandemic PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge. |
CENTRAL HOSPITAL NANCY FRANCE | 2024-04-01 |
| 97 | Leveraging Community-Academic Partnerships and Social Networks to Disseminate Vaccine-Related Information and Increase Vaccine Uptake Among Black Individuals with Rheumatic Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To establish the efficacy of a community-based POL (Popular Opinion Leader) intervention with two different trainings designed to increase COVID-19 vaccine and booster uptake and reduce hesitancy among social networks of Black individuals with rheumatic conditions. The investigators will also determine the structure and composition of the personal and outreach social networks of POLs. |
ROSALIND RAMSEY-GOLDMAN; | 2024-03-15 |
| 98 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating various interventions for use in the treatment of autonomic dysfunction symptoms, including cardiovascular complications and postural orthostatic tachycardia syndrome (POTS), in PASC participants. The interventions tested will include non-pharmacologic care and pharmacologic therapies with study drugs. |
KANECIA OBIE ZIMMERMAN; | 2024-03-11 |
| 99 | COVID-19 Rice Drug Is Brand Name of Drug Related Papers Related Patents Related Grants Related Experts View Highlight: COVID-19 Rice Drug Serial Number: 12401 Code Name: Covid19R Covid 19 Drug Powder Packets Whole Natural Purity 20 -1 g Packets Net Weight 0.7 oz (20 g) |
DO VAN TIN; | 2024-03-05 |
| 100 | A Phase 3, Multicenter, Observer-blind, Randomized, Controlled Study to Evaluate The Immunogenicity, Reactogenicity, and Safety of A Self-Amplifying RNA COVID-19 Vaccine (ARCT-2303), Administered Concomitantly With Quadrivalent Influenza Vaccines, in Adults PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, observer-blind, randomized, controlled phase 3 study to evaluate the immunogenicity, reactogenicity, and safety of an investigational self-amplifying RNA COVID-19 vaccine (ARCT-2303) administered concomitantly with quadrivalent influenza vaccines or standalone in adults who previously received authorized COVID-19 vaccine. |
ARCTURUS THERAPEUTICS | 2024-03-01 |
| 101 | Evaluation of Prevalence and Risk Factors of Persistent SARS-CoV-2 Infection in Immunocompromised Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Spontaneous international multicenter retrospective and prospective observational study which objective is to evaluate the prevalence and risk factors of persistent SARS-CoV-2 infection within a population of hematology patients with humoral immunity deficiency. |
MADDALENA GIANNELLA; | 2024-03-01 |
| 102 | Mitoquinone/mitoquinol Mesylate As Oral and Safe Postexposure Prophylaxis for Covid-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Adults who do not have major health, kidney, gastrointestinal disease will be randomized to receive oral mitoquinone/mitoquinol mesylate (Mito-MES) versus placebo to prevent the development and progression of COVID-19 after high-risk exposure to a person with confirmed SARS-CoV-2 infection. |
THEODOROS KELESIDIS; | 2024-03-01 |
| 103 | Collateral Effects of Pandemics – Care for Informal Caregivers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a workpackage in the German research consortium COLLPAN. The study will map collateral effects in terms of psychosocial and spiritual burden of informal caregivers during after the pandemic and identification/mapping of risk factors.It will also map available therapeutic and preventive interventions and relief of this burden for the present situation and for future pandemics. |
LUKAS RADBRUCH; | 2024-03-01 |
| 104 | Severe Group A Streptococcus Infections in Children During The COVID-19 Pandemic: An Interrupted Time-series Analysis in Paris, France, 2018-2023 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Streptococcus pyogenes, commonly referred to as Group A Streptococcus (GAS), has the ability to induce a diverse range of illnesses. In several European countries and the United States, a notable surge in invasive GAS (iGAS) infections has been documented since mid-2022. This sharp increase contrasts with the gradual rise in iGAS incidence observed among children over the past three decades. As demonstrated for several viral infections, the recent upturn in iGAS infections is potentially linked to the relaxation of mitigation measures implemented during the COVID-19 pandemic, such as face mask usage and school closures. Since November 2022, … |
JÉRÉMIE COHEN; | 2024-03-01 |
| 105 | Immunogenicity to SARS-CoV-2 of Co-administering Bivalent MRNA BNT162b2 Booster and Quadrivalent Influenza Vaccine Among Healthy Volunteers: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study, a pilot randomized controlled trial, single-blind (outcome assessor), evaluating the immune response (both humoral and cell-mediated) against SARS-CoV-2 and the safety of three different vaccine administration approaches: the SARS-CoV-2 mRNA vaccine alone, the influenza vaccine alone, and the co-administration of both vaccines. |
SARUNYOU CHUSRI; | 2024-03-01 |
| 106 | NUTRITIONAL OPTIMIZATION IN THE DIFFERENT PHASES OF CRITICAL ILLNESS. Comparison of The Urea/Creatinine Ratio With Indirect Calorimetry PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the efficiency of the urea/creatinine ratio as a catabolism marker compared to indirect calorimetry to optimize nutritional support in critically ill patients. |
JOSÉ RAIMUNDO ARAUJO DE AZEVEDO; | 2024-03-01 |
| 107 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diaphragm is the principal muscle of inspiration. Diaphragmatic dysfunction is seen in many conditions including following intubation, lung disease, prolonged ventilation, neuromuscular disease, phrenic nerve injury. The possible mechanisms of diaphragmatic dysfunction in patients with COVID19 are critical illness myopathy, ventilator-induced diaphragm dysfunction, iatrogenic phrenic nerve injury particularly secondary to line placement, post-infectious inflammatory neuropathy of the phrenic nerve, or possibly direct neuromuscular involvement of the SARS- CoV-2 virus given expression of the angiotensin- … |
FARHA IKRAMUDDIN; | 2024-03-01 |
| 108 | A Retrospective Observational Non-Interventional Study (NIS) to Assess Patient Characteristics and Healthcare Resource Use (HRU) Among COVID-19 Patients With or Without Nirmatrelvir/Ritonavir (PAXLOVID™) Treatment in The Kingdom of Bahrain PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to collect information on the: – general information of a group of people such as their age, sex – clinical information of the patients such as any other illness before having COVID 19. – the number of COVID-19 patients who meet and follow the most up to date World Health Organization (WHO) recommendations for medication to treat COVID-19 (such as version 14, published 10Nov2023) compared to Kingdom of Bahrain national recommendations – … |
PFIZER | 2024-02-29 |
| 109 | Inclusion of Calcifediol in The Hospital Therapeutic Protocol for Treatment of SARS-CoV-2 Disease (COVID-19). Mortality Analysis. Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome variables, such as admission to the Intensive Care Unit (ICU), to Gerencia de Atención Integrada (GAI) de Albacete. Complejo Hospitalario Universitario de Albacete. Albacete (Spain), based on the files of the MXXI medical records, Information System of the Laboratory (ISL) and Pharmacy. |
COMPLEJO HOSPITALARIO UNIVERSITARIO DE ALBACETE | 2024-02-21 |
| 110 | Impact of Covid-19 on Occupational Dermato-allergology Consultations of Health Peronnel PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Occupational dermatitis is the second most common occupational disease in Europe, with a notable prevalence among healthcare workers-approximately 20% of whom are affected. However, these figures may be underestimated due to underreporting. Despite the presumed scale of the problem, … |
CENTRE HOSPITALIER INTERCOMMUNAL CRETEIL | 2024-02-19 |
| 111 | Acute Cardiovascular Responses to A Single Exercise Session in Patients With Post-Covid-19 Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the study is to compare the acute cardiorespiratory and perceptual responses to a physical exercise session in those infected by Covid-19 with and without persistent symptoms. |
RAPHAEL MENDES RITTI DIAS; | 2024-02-15 |
| 112 | Effects of Physiotherapy Via Video Calls on Cardiopulmonary Functions, Physical Function, Cognitive Function, and Quality of Life in Patients With COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effects of Physiotherapy Via Video Calls on Cardiopulmonary Functions, Physical Function, Cognitive Function, Activity Daily Livings, and Quality of Life in Patients With COVID-19. |
POORIPUT WAONGENNGARM; | 2024-02-09 |
| 113 | Safety and Tolerability of Adjunct Dexamethasone in Addition to Standard of Care Antiviral Therapy Compared to Standard of Care Antiviral Therapy Alone for The Treatment of Moderate to Severe Lassa Fever PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dexamethasone is a corticosteroid which can modulate inflammatory-mediated tissue damage associated with a wide range of infectious diseases. Dexamethasone is routinely used for treatment of tuberculous meningitis and for pneumococcal meningitis in adults. In Coronavirus Disease 2019 (COVID-19) dexamethasone is also effectively preventing immune mediated damage of the lungs. There is also indication that dexamethasone may be promising in severe LF. |
BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE | 2024-02-05 |
| 114 | Delayed Surgical Obturator As A Treatment Option After Mucormycosis Post COVID-19: A Prospective Observational Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: During the COVID-19 pandemic, there was a lot of reporting of COVID-19-associated mucormycosis cases. Managing this condition posed a new challenge to clinicians. Management includes therapeutic drugs and aggressive surgical debridement. Due to the unpredictability of disease prognosis and the possible recurrence of the disease, rehabilitation with delayed surgical obturators is beneficial for patients. Hence, the current study aimed to evaluate the impact of delayed surgical obturators on quality of life of COVID-19-associated mucormycosis patients post-maxillectomies |
MOHAMMED EL-SAWY; | 2024-02-04 |
| 115 | Evaluation of Educational Interventions Targeting Beliefs About Human Papillomavirus (HPV) Among Female Employees PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effects of two different educational training programs on beliefs about Human Papillomavirus (HPV) in a group of female hospital employees. The main questions it aims to answer are: • Within the scope of the study, … |
SELVA DILAN GOLBASI KOC; | 2024-02-01 |
| 116 | The Effectiveness of A Health Promotion Program for Older People With Post-Covid-19 Sarcopenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the prevalence of sarcopenia in older people with post-COVID-19 living in Ratchatewi district, Bangkok and to test the effectiveness of health promotion program for older people with post-COVID-19 Sarcopenia. The main questions it aim to answer are: • How many is the prevalence of sarcopenia in older people with post-COVID-19 living in Ratchatewi district, Bangkok? • Can the health promotion program improve muscle mass and muscle strength in older people with post-COVID-19 Sarcopenia ? Participants will be asked eating protein supplement one scoop /day and exercising 2 times/week for 3 months. |
WANABHORN TONGCHOM; | 2024-02-01 |
| 117 | A Phase L Study to Assess The Safety and Tolerability of PET Imaging With [11 C]CPPC [5-cyano-N-( 4-( 4-[l L CJ Me1hylpiperazin-l-yl)-2-(Piperidin-l-yl)Phenyl)Furan-2-carboxamide] Radioligand and Magnetic Resonance (MR) Imaging in Patients With Long COVID Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to evaluate the safety of using the [5-cyano-N-(4-(4-[11C]Methylpiperazin-1-yl)-2-(Piperidin-1-yl)Phenyl)Furan-2-carboxamide] ([11C]CPPC) radiotracer in positron emission tomography (PET) imaging of people with history of COVID-19 infection, with and without symptoms. The investigators are also interested to see whether use of this radiotracer reveals imaging differences between patients with history of COVID-19 infection and still exhibiting symptoms or healthy patients with history of COVID-19 infection but exhibiting no current symptoms. |
LICIA LUNA; | 2024-02-01 |
| 118 | A Phase 1/2 Randomized Study to Evaluate The Safety, Tolerability, and Immunogenicity of A Modified RNA COVID-19 Vaccine and A Recombinant Influenza Vaccine Administered As A Single Injection in Healthy Adults 50 Years of Age or Older PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to see if combining a licensed COVID-19 vaccine and a licensed influenza vaccine into a single shot is safe and can help produce antibodies to defend the body against both SARS-CoV-2 (the virus that causes COVID-19) and influenza. Participants enrolled in this trial will be healthy adults, 50 years of age or older. |
PFIZER | 2024-01-31 |
| 119 | Master Protocol for Early Treatment and Post-Exposure Prophylaxis of COVID-19 Adaptive Platform Trial PROTECT-APT 1 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is an adaptive, randomized, double blind, platform trial evaluating promising investigational products (IP) for safety and efficacy as early outpatient treatment and post-exposure prophylaxis for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). |
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE | 2024-01-29 |
| 120 | Immunobridging Study: Immunogenicity and Safety of INAVAC (Vaksin Merah Putih – UNAIR SARS-CoV-2 (Vero Cell Inactivated)) Vaccine As Homologue Booster in Adult Subjects in Indonesia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this open-label clinical trial is to evaluate the safety and immunogenicity of INAVAC (Vaksin Merah Putih – UNAIR SARS-CoV-2 (Vero Cell Inactivated)) Vaccine as Homologue Booster in Adult Subjects in Indonesia. The main question it aims to answer is: To evaluate the humoral immunogenicity profile at 28 days following vaccination with INAVAC vaccine as homolog booster administered intramuscularly in healthy adults age 18 years and above. Participants will be administered one dose of vaccination for the third dose (booster vaccination) intramuscularly. |
DOMINICUS HUSADA; | 2024-01-29 |
| 121 | Performance and Safety Assessment of HUMER STOP VIRUS Nasal Spray in Adults With Early Symptoms of Viral Respiratory Infection (COVID-19, Flu, Common Cold): An Open-label Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There is no cure for cold or flu, most people recover in about within two weeks. Paracetamol may be used to reduce aches or treat fever, headache, … |
CAROLE PERRIN; | 2024-01-26 |
| 122 | Dysfunction of Olfaction After SARS-CoV-2 Infection: Morphological and Histomolecular Investigation of Olfactory Cleft Biopsies and Cytobrushes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls. |
LAURA VAN GERVEN; | 2024-01-24 |
| 123 | Effectiveness of BNT162b2 Formulations Using State Vaccine Registry and Insurance Claims Data Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to learn about how well different versions of the Pfizer-BioNTech COVID-19 vaccine (called BNT162b2) work at preventing death, severe COVID-19 that requires a trip to the hospital, and overall use of healthcare resources, such as needing to go the doctor or urgent care due to illness. Pfizer is not enrolling any participants for this study. Instead, existing data from different health data sources will be used to help answer the scientific questions Pfizer is interested in learning more about. |
PFIZER | 2024-01-17 |
| 124 | Evaluation of A Screen and Treat Protocol for Influenza in Socially Vulnerable Communities PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to demonstrate that the laboratory can mitigate respiratory virus transmission in underserved populations by using laboratory data to identify communities at risk for increase vial activity (hot spots) and intervening with a test-to-treat model provides increased access to influenza diagnostics and treatment in vulnerable and underserved communities. |
MICHAEL CROSSEY; | 2024-01-15 |
| 125 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine if low-dose naltrexone (LDN) reduces fatigue, improves related symptoms, and reduces inflammatory markers in peripheral blood in cases with Post-COVID-19 Fatigue Syndrome (PCFS) from COVID-19 (i.e. confirmed SARS-CoV-2 case). LDN refers to naltrexone given in doses of 1-4.5 mg. Overall, studies have found that LDN is safe and well-tolerated. It may help to reduce pain and inflammation and improve well-being and immune function.The trial will be conducted by the Complex Chronic Diseases Program (CCDP) at BC Women’s Hospital and will demonstrate whether LDN could benefit a large number of people with PCFS. |
LUIS NACUL; | 2024-01-15 |
| 126 | Mitigating Mental and Social Health Outcomes of COVID-19: A Counseling Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to develop a comprehensive mental health counseling programpurposed to address the social determinant of health impacts of the coronavirus disease of2019 (COVID-19). The main questions the investigators aim to answer are: 1) What are themental and social determinant of health impacts of a COVID-19 diagnosis, and 2) What are theimpacts of a counseling program implemented to address those impacts? Participants willparticipate in individual interviews, attend individual and group counseling, and be providedresources related to their social determinants of health needs. |
IDAHO STATE UNIVERSITY | 2024-01-15 |
| 127 | Evaluation of Gas Composition in The Oropharynx During High-flow Oxygen Therapy Through Nasal Cannula in Healthy Volunteers: A Physiological Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Observational, randomized studies and their meta-analyses have shown the high effectiveness of high-flow oxygen therapy through nasal cannulas, reaching 50-60% in acute hypoxemic respiratory failure. Some bench studies showed the advantages of high-flow oxygen therapy compared with standard oxygen therapy, consisting in reducing the anatomical dead space and maintaining a given inspiratory oxygen fraction in the hypopharynx of the mannequin, but the actual state of the gas composition of the hypopharynx was not studied. The study aim is measurement of the inspiratory (FiO2) and expiratory (FeO2) fractions of oxygen, … |
ANDREY I YAROSHETSKIY; | 2024-01-09 |
| 128 | Can Routine Consultations Be Used to Reduce COVID-19 Misinformation and Increase Vaccine Uptake? An Experimental Study in Ghana PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Whilst Ghana was one of the first countries to start vaccinating its population against COVID-19, less than 30% of the population was fully vaccinated at the end of 2022. To improve COVID-19 vaccine uptake, the government has so far relied on two strategies: sensitization in communities and specific national vaccination days. Against the backdrop of strict budget constraints and the return to normalcy in health-seeking behaviours, … |
LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE | 2024-01-08 |
| 129 | Patient-Reported Outcomes Associated With COVID 19 and Influenza: A Prospective Survey Study on Outpatient Symptomatic Adults With Laboratory-Confirmed Illness in The United States PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to understand: – the symptoms of COVID-19 or influenza – health-related outcomes of people with COVID-19 or influenza – the effects of vaccines in people with COVID-19 or influenza. This study will take in participants who are: – 18 years or older – … |
PFIZER | 2024-01-08 |
| 130 | Prospective Open-Label Pilot Study of Arginine Replacement Therapy in Children Hospitalized With COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate if receiving doses of arginine (a protein in the body) will improve mitochondria function in children with COVID-19. The study will be performed at the Children’s Healthcare of Atlanta, Arthur M. Blank Hospital. Patients will be randomized to receive one of three doses of arginine three times a day for five days or at discharge whichever comes first. |
CLAUDIA R. MORRIS; | 2024-01-08 |
| 131 | Efficacy of CPAP in Reducing Cognitive Fog in Post-COVID Patients With Sleep Apnea PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, observational study evaluating the relationship between severity of sleep apnea with severity of cognitive fog and if treatment of sleep apnea with CPAP improves cognitive fog in a cohort of post COVID patients with sleep apnea. |
VENKATESH KRISHNAMURTHY; | 2024-01-04 |
| 132 | A Cross-sectional Study of Ocular Manifestations During The Covid-19 Pandemic in Hubei Province PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: To investigate the clinical features of ocular manifestations during the novel coronavirus pneumonia pandemic in Hubei at the end of 2022 |
MIN KE; | 2024-01-01 |
| 133 | PROmotion of COVID-19 BOOSTer VA(X)Ccination in The Emergency Department – PROBOOSTVAXED PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this cluster randomized clinical trial is to test the efficacy of messaging interventions to increase booster vaccine uptake in adults in the emergency department(ED). The main question[s] it aims to answer are: – does vaccine messaging increase booster vaccine uptake at 30 days post ED visit – does asking about vaccine acceptance increase booster vaccine uptake at 30 days post ED visit All participants will answer two surveys about booster vaccines and intervention participants will receive messaging about booster vaccines.Intervention participants will receive either a question about booster vaccine acceptance, … |
ROBERT RODRIGUEZ; | 2024-01-01 |
| 134 | Using A Telehealth Model to Address Vaccine Hesitancy and Increase Vaccine Completion Among Vulnerable Communities in Southeastern Louisiana PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a 24-30 month behavioral intervention study to assess the impact of enrolling individuals a clinical pharmacist run telehealth education focused on wellness and vaccination. Individuals will be randomized to either a wellness only model focusing on nutrition, diabetes and hypertension or a wellness model with a vaccination education component. All participants will complete individual and group based interventions. Individuals will be recruited from industries with high risk for COVID-19 and other respiratory illness infection, such as health workers, teachers aides and the food industry. We are recruiting individuals who identify as African-American, Hispanic, … |
SARA AL-DAHIR; | 2024-01-01 |
| 135 | Impact of Prone Position Duration and Sex Differences on Ventilation and Oxygenation in COVID-19 ARDS Patients: A Retrospective Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this observational study is to learn the effects of prone position duration on patient outcomes in patients with severe acute respiratory distress syndrome (ARDS) due to Coronavirus Disease – … |
OGUZHAN KAYHAN; | 2024-01-01 |
| 136 | Pilot Study of An Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate The Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Long Covid is a multisystem condition comprising often severe symptoms that follow a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Long COVID often manifests as fatigue and neurocognitive impairment (also referred to as ‘brain fog’). Based on two systematic reviews of Covid-19 cases in neonates, children and adolescents under 19 years of age, fatigue caused by Long Covid can persist for years and can lead to work disability and labour shortages, posing a public health emergency with lasting health, mental, and economic impacts. To date, … |
ZAMIR HUSSAIN SUHAG; | 2024-01-01 |
| 137 | A Prospective, Non-interventional, Observational Clinical Validation Study to Analytically Validate The A&M Breathalyzer PROTECT Kiosk Breath Capture System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this effort will be to optimize and operationalize innovative passive surveillance systems and in parallel, the effort will identify, evaluate, and transition groundbreaking new technologies in diagnostics for operationalization. To meet the objective and execute the deliverables for this program of effort, the A&M Breathalyzer PROTECT Kiosk will be tested, modified and validated at Brooke Army Medical Center (BAMC). The collaborative efforts between the PI, Dr. Michael Morris at BAMC and Co-Investigator Dr. Tony Yuan at USU- … |
TONY YUAN; | 2023-12-27 |
| 138 | A Phase 2/3 Single-Arm, Open-label Study to Evaluate The Safety, Pharmacokinetics and Efficacy of Obeldesivir in Pediatric Participants With COVID-19 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to learn more about the safety and tolerability of obeldesivir (ODV) in children and adolescents with coronavirus disease 2019 (COVID-19). The primary objectives are to evaluate the plasma pharmacokinetics (PK), safety and tolerability of ODV in pediatric participants with COVID-19. |
GILEAD SCIENCES | 2023-12-26 |
| 139 | A PHASE 3, RANDOMIZED, OBSERVER-BLINDED STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A COMBINED MODIFIED RNA VACCINE CANDIDATE AGAINST COVID-19 AND INFLUENZA IN HEALTHY INDIVIDUALS PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to understand the safety and effects of a combined influenza and COVID-19 vaccine. This combined vaccine is compared to separate vaccines for the protection against influenza and SARS-CoV-2. Influenza and COVID-19 are diseases that can spread easily from one person to another and cause body aches, fever, cough, and other symptoms. Giving both influenza and COVID-19 vaccines together against influenza and SARS-CoV-2 could provide great benefits to both patients and caregivers in terms of simple and easy care. Around 7500 participants will be assigned into 1 of 4 vaccination groups (Group A, B, … |
BIONTECH SE | 2023-12-21 |
| 140 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Clinical Study to Evaluate The Efficacy, Safety, and Immunogenicity of Booster Vaccination With Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell) for The Prevention of SARS-CoV-2 Infection in A Population of 18 Years of Age and Older PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell) developed by WestVac Biopharma Co., Ltd. is a monovalent modified vaccine designed against Omicron XBB.1.5. This is a multi-center, randomized, double-blind, placebo-controlled phase 3 clinical study with two cohorts, i.e. the immuno-bridging observational cohort and the efficacy observational cohort, aims to evaluate the efficacy, safety, and immunogenicity of booster vaccination with Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell) for the prevention of SARS-CoV-2 infection in a population of 18 years of age and older. |
WESTVAC BIOPHARMA | 2023-12-19 |
| 141 | Safety Profile of Booster IndoVac COVID-19 Vaccination in Healthy Populations Aged 18 Years and Above PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is Post Authorization Safety Study (PASS) Phase IV of Booster IndoVac COVID-19 Vaccination |
HINDRA IRAWAN SATARI; | 2023-12-18 |
| 142 | Assessing The Impact of COVID-19 on HMPV Incidence and Severity Among Adults PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Human metapneumovirus (HMPV) is primarily recognized as a childhood pathogen, but its impact on adults remains largely underestimated. This study investigates the prevalence, clinical characteristics, and post-COVID-19 trends of HMPV infection among adults in Istanbul, Turkey. |
ACIBADEM UNIVERSITY | 2023-12-15 |
| 143 | An Observational Study to Describe EVUSHELD™ (Tixagevimab/Cilgavimab) Pre-exposure Prophylaxis in Real-world Setting in Japan PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational, cohort study that will use secondary data to describe the baseline demographics and clinical characteristics in patients who received EVUSHELD as PrEP against SARS-CoV-2 infection/COVID-19 in Japan. All patients who have a record of administration of EVUSHELD in the database will be included in the study. The index date will be defined as the date of first EVUSHELD administration in the database (Day 0) and the patients will be followed up to 6 months after the index date (Day 1 to 180). The look back period is defined as the 12-month period prior to index date (Day -360 to -1). The exposure of interest will be defined as the administration of EVUSHELD for use as PrEP against COVID-19. As the result of feasibility assessment, sample size of the study expected to be approximately 280. |
ASTRAZENECA | 2023-12-15 |
| 144 | A Randomized, Double-blind, Parallel, Placebo-control Study to Evaluate The Efficacy and Safety of Formosa 1-Breath Free (NRICM101) in Subjects With The Symptoms of COVID-19 or Influenza-like PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Formosa 1-Breath Free (NRICM101) has been widely known in Taiwan to treat COVID-19. However, there is no phase III pivotal clinical trial of Formosa 1-Breath Free (NRICM101) . In order to obtain scientific, standardized, and comparable clinical results, … |
CHINA MEDICAL UNIVERSITY HOSPITAL | 2023-12-15 |
| 145 | EFFECTS OF WHEY PROTEIN SUPPLEMENTATION ON CARDIOPULMONARY, MUSCLE AND IMMUNOHEMATOLOGICAL RESPONSES OF POST-COVID-19 PATIENTS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: COVID-19 left consequences in different organs from months to years requiring different types of rehabilitation. In fact, a severe loss in the lung function, and in the respiratory and peripheral muscle strength is commonly observed in post-COVID-19 patients. Objectives: Thus, the present study investigated whether 30 days of supplementation with a nutritional blend (ImmuneRecov®; composition: whey protein concentrate, astaxanthin, creatine, selenium, vitamin C, glutamic acid, tryptophan, magnesium) would help to minimize the respiratory (lung function) and muscular (respiratory and peripheral muscles) sequelae in post-COVID-19 patients. |
RODOLFO DE PAULA VIEIRA; | 2023-12-10 |
| 146 | Special Investigation for Booster Dose of Comirnaty (ｍonovalent: Omicron XBB.1.5.) Intramuscular Injection in Children of The 6 Months Though 4 Years of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this post-marketing study is to assess the safety of Comirnaty monovalent XBB.1.5. for booster vaccination children ages 6 months though 4 years under actual use medical practice. |
PFIZER | 2023-12-08 |
| 147 | Long Term Impact of Covid-19 Vaccination on Adolescence PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Long term impact of COVID 19 vaccination on dizziness-related disability and balance in adolescence |
ALAA NOURELDEEN KORA; | 2023-12-06 |
| 148 | Real-World Effectiveness and Safety of Oral Azvudine in Hospitalized Patients With COVID-19: A Multicenter, Retrospective, Cohort Study PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: To establish a real-world clinical cohort and database of Azvudine in the treatment of SARS-CoV-2 infection, and to provide stable and reliable evidence for the clinical efficacy and safety evaluation of azvudine in the treatment of SARS-CoV-2 infection. |
ZHIGANG REN; | 2023-12-05 |
| 149 | A Randomized, Blinded, Placebo-Controlled, Dose Escalation Phase 1 Trial of Recombinant COVID-19 Trivalent (XBB.1+BQ.1.1+Prototype) Protein Vaccine （CHO Cell）（LYB002V14） in Booster Vaccination in Participants Aged 18 Years Old and Above PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, blinded, and dose escalation phase I trial in males and non-pregnant females, starting at 18 years of age, inclusive, who are in good health and meet all eligibility criteria. This clinical trial is designed to assess the safety and immunogenicity of Recombinant COVID-19 Trivalent (XBB.1+BQ.1.1+Prototype) Protein Vaccine （CHO Cell）（LYB002V14）. |
QIN F YU; | 2023-12-04 |
| 150 | Clinical Performance Study for EDAN’s COVID-19/Flu A/Flu B/RSV Test Kits on Subjects Suspected of Respiratory Infection PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this clinical performance study is to evaluate and further validate the clinical performance of: 1. ClariLight Influenza A/B & SARS-CoV-2 test kits and 2. ClariLight Influenza A/B & RSV test kits, for the qualitative detection and differential diagnosis of SARS-CoV-2, influenza A, influenza B, and respiratory syncytial virus (RSV) present in anterior nasal and oropharyngeal swab, in combination with an automated molecular diagnostic analyzer and sample collection tube by comparing them against a CE marked, in-vitro diagnostic device, used in the standard of care. |
EDAN INSTRUMENTS | 2023-12-01 |
| 151 | Brief Digital Intervention to Increase COVID-19 Vaccination Among Individuals With Anxiety or Depression PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic has led to a mis/disinformation ecosystem that promotes divergent views of vaccine efficacy, as well as the legitimacy of science and medicine. Individuals are confronted with vaccine-related information from a multitude of sources, posing a challenge to identifying inaccurate information. COVID-19 vaccine uptake is lower among people with anxiety and depression than in the general population, … |
DENIS NASH; | 2023-12-01 |
| 152 | Post-COVID-19 Condition: Observational Study in Vietnam PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to estimate the prevalence of the post-COVID-19 condition in confirmed mild, moderate, and severe COVID-19 adult patients in Hai Phong, Vietnam. |
ANRS EMERGING INFECTIOUS DISEASES | 2023-12-01 |
| 153 | Project PEACH2: Promoting Engagement and COVID-19 Testing for Health PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: PEACH2 is a community-based study, targeting individuals affected by diabetes. Study participants will be randomized into the PEACH2 Intervention Arm or the Control Arm. The intervention lasts for 4 months and participants will be followed for 10 months in total. |
MARY BETH WEBER; | 2023-12-01 |
| 154 | Home-Based Respiratory Muscle Strength Training Program for Individuals With Post-COVID-19 Persistent Dyspnea PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the extent to which a 12-week respiratory rehabilitation program consisting of inspiratory and expiratory breathing exercises compared to expiratory breathing exercises alone will help to improve shortness of breath, respiratory symptoms, breathing function, distance walked, and quality of life in those who are experiencing persistent shortness of breath after having had COVID-19. Measurements will take place at the beginning, 6 weeks, and at 12 weeks in the study. |
CONSTANCE VISOVSKY; | 2023-12-01 |
| 155 | Pseudomonas Aeruginosa Infections Among COVID-19 Patients in Intensive Care Units at Nancy University Hospital During The First Three Epidemic Waves: A Retrospective Study (Pyo-COVID-3) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: P. aeruginosa is an opportunistic bacterium known to be responsible for numerous healthcare-associated infections, particularly in intensive care units (ICU). The frequency of these infections seems to have increased during the first waves of the COVID-19 pandemic. Identifying cases of co-infection and secondary infections with P. aeruginosa in patients with COVID-19 would provide a better understanding of the epidemiological evolution and characteristics of infected patients. Treatment of P. aeruginosa infections requires the use of antibiotics. Antibiotic resistance is a growing problem, … |
FLORENTIN ARNAUD; | 2023-12-01 |
| 156 | Efficacy of Adjunctive Sodium Citrate in Smell Retraining for People With Post-Acute Sequelae COVID-19 Olfactory Dysfunction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot study is to assess the feasibility and impact of using sodium citrate nasal spray as an adjunct to olfactory retraining in participants with long-term post-COVID-19 olfactory dysfunction. The main questions it aims to answer are: * Is sodium citrate nasal spray in addition to smell retraining feasible for participants to use in terms of participant need/desire, adherence, … |
BRENT A. SENIOR; | 2023-12-01 |
| 157 | Potential Role of Diaphragmatic Muscle Weakness As A Cause of Persistent Exertional Dyspnea in Patients With COVID-19 Disease Without Hospitalization PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles. The aim of the project is to measure respiratory muscle function and strength in our respiratory physiology laboratory in patients who were not hospitalized during the acute COVID-19-infection but still complain of different persistent symptoms including exertional dyspnea and fatigue. |
JENS SPIESSHÖFER; | 2023-12-01 |
| 158 | Effects of Rehabilitation Combined With A 12-week Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19 – A Randomized, Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Infection with SARS-CoV-2 virus leads to persistent symptoms for more than 12 weeks in 15% of cases (post-COVID syndrome). Symptoms like fatigue, dyspnoea, limitations in physical performance and activities, head ache, anxiety symptoms, and depression are heterogenous which limit physical health and participation in daily life activities. In the last years, multidisciplinary rehabilitation programs showed benefits in quality of life and symptom intensity in patients with post-COVID. Therefore, … |
ANDREAS REMBERT KOCZULLA; | 2023-12-01 |
| 159 | Clinical Evaluation of The Panbio™ COVID-19/Flu A&B Panel to Support Home Use PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to demonstrate the performance and usability of the the Panbio™ COVID-19/Flu A&B Panel Self Test in the hands of patients/lay-users. Nasal swabs will be self-collected by subjects/lay-users who are symptomatic and suspected of viral respiratory infection. They will perform, read, and interpret the test result. The test is intended for nonprescription home use for qualitative detection of COVID-19, Influenza A antigen, and Influenza B antigen. |
ABBOTT RAPID DX | 2023-11-30 |
| 160 | A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Safety, Tolerability, Pharmacokinetics, and Immunogenicity of REGN17092, An Anti-SARS-CoV-2 (COVID-19) Monoclonal Antibody, in Adult Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn about the safety and tolerability of different doses of REGN17092 administered with a needle either under the skin (called subcutaneous) or into a vein (called an infusion) in healthy participants. This is the first time that REGN17092 will be given to people. Other aims are to assess: * How much of the study drug is in the blood at different times * Whether the body makes its own antibodies against the study drug (which could make the drug less effective or lead to side effects) |
REGENERON PHARMACEUTICALS | 2023-11-28 |
| 161 | A Phase I, Open-label, Randomized, Active-Controlled Study in Adults to Characterize The Safety and Immunogenicity of AZD9838 and AZD6563 Vaccine (ARTEMIS-C) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to characterize the safety and immunogenicity of AZD9838 and AZD6563 when administered as a single dose vaccination against SARS-CoV-2 in adults. |
ASTRAZENECA | 2023-11-27 |
| 162 | A Randomized, Double Blind, Placebo-Controlled, Multiple Ascending Dose, Phase 1 Study of SLV213 in Healthy Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study will evaluate the safety, tolerability, and pharmacokinetics (PK) of multiple ascending doses (MAD) of SLV213 administered orally (PO) every 12 hours (Q12h) daily for 7 days in healthy male and female participants, 18-65 years of age. This study will help to select the most likely suitable dose (e.g., at Maximum Tolerated Dose [MTD]) for the treatment of patients with COVID-19 in a pivotal study. This phase 1 double blind, placebo-controlled study will consist of three sequential cohorts of 12 participants each (8 SLV213 and 4 placebo), at doses of 400 mg Q12h, 600 mg Q12h, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2023-11-25 |
| 163 | Clinical Validation of The Aptitude Medical Systems Metrix COVID/Flu Test for Detection of SARS-CoV-2 and Influenza A/B in Point-of-Care and Non-Laboratory Settings PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The Metrix COVID/Flu Test will be evaluated for use in Point-of-Care and Non-Laboratory settings in a home testing environment utilizing the clinical study design described herein. The study will take place in simulated home environments which will be set up within or near active clinical settings (e.g., urgent care facilities). This will be a prospective study conducted at three or more investigational sites located within the United States for the clinical validation of the Metrix COVID/Flu Test for the differential detection of SARS-CoV-2, Influenza A, … |
QIN YANG; | 2023-11-20 |
| 164 | Assessment of Left Atrial Function of COVID-19-recovered Patients During The Surge of Omicron Variants By Two-dimensional Speckle Tracking Echocardiography PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to retrospectively analyze left atrial function in mild to moderate COVID-19-recovered patients. The main questions it aims to answer are: – Whether left atrial function is involved in patients with mild to moderate COVID-19 after recovery. – What are the factors that may be associated with persistent heart-related symptoms (including chest pain, chest tightness, palpitations, shortness of breath, or postural tachycardia) in patients with mild to moderate COVID-19 ? Participants will undergo transthoracic echocardiography to obtain conventional ultrasound parameters, two-dimensional strain parameters will been obtained through software post-processing, … |
HAIYAN WANG; | 2023-11-20 |
| 165 | Additional Recombinant COVID-19 Humoral and Cell-Mediated Immunogenicity in Immunosuppressed Populations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine whether providing a recombinant booster COVID-19 vaccine improves sustained humoral and cell-mediated immunogenicity against SARS-CoV-2 in immunosuppressed patients with Inflammatory Bowel Disease (IBD) and/or solid organ transplant recipients. 120 participants will be enrolled and can expect to be on study for 6 months. |
FREDDY CALDERA; | 2023-11-20 |
| 166 | Phase IIb/III, Double-Blind, Randomised, Active-Controlled, Multi-Center, Non-Inferiority Clinical Trial, to Assess The Safety and Immunogenicity of A Booster Vaccination With An Adapted Recombinant Protein RBD Fusion Homodimer Candidate Against SARS-CoV-2, in Adults Vaccinated Against COVID-19 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase IIb/III, double-blind, randomised, active-controlled, multi-centre, non-inferiority clinical trial that aims to determine safety, tolerability and immunogenicity of a booster vaccination with a recombinant protein receptor binding domain (RBD) fusion homodimer of XBB.1.16 adapted candidate against SARS-CoV-2 developed by HIPRA (PHH-1V81). |
HIPRA SCIENTIFIC S L U | 2023-11-13 |
| 167 | Assessment of Ventilatory Efficacy in Patients With Fatigue Associated With SARS-CoV2 Infection After Ingestion of Beet Juice PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The lung is the organ most affected by COVID-19. There are patients who successfully overcome the acute COVID-19 infection and their lungs return to a normal state. However, a significant number present dyspnea and fatigue as sequelae without having a pulmonary origin, but with a significant impact on functionality. In our published studies in relation to fatigue in patients with symptoms attributed to persistent COVID, the investigators have shown that there is muscle involvement, observing a decrease in mechanical efficiency. This muscle involvement causes stimulation of ventilation through the ergoreceptors, … |
EULOGIO PLEGUEZUELOS; | 2023-11-13 |
| 168 | Diaphragm Dysfunction After COVID-19 As Determined By Dynamic Chest Radiography PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dynamic chest radiography (DCR) is a rapid and easily performed technique that captures real-time continuous images of the moving chest. COVID-19 has led to various complications and long-term effects, with dyspnea being a common symptom experienced by many patients. Studies conducted abroad have indicated that dyspnea following a new coronavirus infection can be attributed to diaphragm dysfunction. This study using DCR aims to describe diaphragm function in patients after coronavirus disease (COVID-19). |
LIU LAIYU; | 2023-11-10 |
| 169 | Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients. A Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Sleep is an important modulator of the immune response, whereby sleep disturbances (ie, poor sleep quality, insufficient sleep and/or primary sleep disorder, obstructive sleep apnea (OSA)) contribute to inflammatory disease risk and dysregulation of immune response in front of infectious agents. The objective of this study is to evaluate the impact of undiagnosed and non-treated sleep disorders on innate immunity in a cohort of COVID-19 patients and the role of trained immunity induced by influenza vaccination in the innate immune response. |
ANDREA GRAU FREIXINET; | 2023-11-06 |
| 170 | Vale+ Tu Salud: Corner-Based Randomized Trial to Test A Latino Day Laborer Program Adapted to Prevent COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the extent to which LDL report increased adherence with COVID 19 mitigation practices 1 month post intervention. |
MARIA EUGENIA FERNANDEZ-ESQUER; | 2023-11-03 |
| 171 | Pilot Study to Evaluate The Role of An Evidenced-based Chronic-disease Self-management Program to Support Challenges Experiencing Patients Living With Long-COVID and Chronic Diseases in Puerto Rico PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot non-randomized-controlled trial to evaluate the impact of Tomando control de su salud, an evidenced-based intervention for chronic disease self-management in the quality of life of patients living with Long-COVID in Puerto Rico. |
ENID J. GARCIA-RIVERA; | 2023-11-02 |
| 172 | Evaluation of A Training and Support Intervention for General Practitioners Managing Patients With Persistent Symptoms Following A COVID-19 Episode PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of the effectiveness of a training and support intervention for general practitioners treating patients with persistent symptoms after a COVID-19 episode on the patients’quality of life at 3 months. |
BRIGITTE RANQUE; | 2023-11-01 |
| 173 | Development and Qualification of Methods for Analyzing The Mucosal Immune Response to COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The pandemic associated with the SARS-CoV-2 coronavirus has affected over 760 million individuals worldwide, resulting in more than 6.9 million deaths. France has also been heavily impacted, with over 39.8 million infections and 167,000 deaths. SARS-CoV-2 primarily causes an upper respiratory tract infection transmitted through the air. When it reaches the lungs, it leads to a severe acute respiratory illness called COVID-19. The body’s response to this viral assault primarily occurs at the level of the respiratory mucosa. This mucosal response is complex, … |
ZOHA MAAKAROUN-VERMESSE; | 2023-11-01 |
| 174 | Influence of Physical Training Protocols in Hypoxic, Normobaric and Hypobaric Environments, on The Immune, Metabolic Response and Cardiopulmonary Behavior in Athletes Convalescent From Covid-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: COVID-19 has significantly impacted sports globally, with event postponements, training disruptions, and wide-ranging concerns. SARS-CoV-2 infection can result in hyperinflammation and cardiopulmonary changes, with hypoxia as an aggravating sign. Hypoxia triggers complex immunometabolic mechanisms, including activation of HIF-1α and induction of HLA-G expression. Hypoxia training protocols benefit aerobic capacity and sports performance, with potential immunological impact. Studying immunometabolic markers in this context can improve athletic preparation and athletes’ general health. |
CRISTINA MONTEIRO; | 2023-11-01 |
| 175 | The Objective of Our Study Is to Evaluate The Medium and Long-term Clinical Efficacy of Acupuncture in Patients With Post Covid Related Mild Cognitive Impairment (MCI) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: After being infected with Covid-19, many people developed to Brain fog. The treatment strategy now is based on the presumed pathological phenomenon and the physician’s clinical experience. Acupuncture has been used to improve cognitive dysfunction caused by central nervous system diseases for many years. A randomized rater-blinded controlled study is proposed to see the efficacy of acupuncture for brain fog. |
CHIEN YU HUANG; | 2023-11-01 |
| 176 | EB-PCC-01, A Pilot Randomized, Sham Controlled Safety and Efficacy Study of The EmitBio™ RD-X19 Treatment Device in Subjects With Post COVID-19 Condition (PCC) in The Outpatient Setting PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Duration of Treatment: 7 days, 2 times per day. Following Randomization on Week 1 Day 1, Subjects will continue to have televisits and rate symptoms and upright activity weekly during a 5 week follow up. Subjects will be followed via in clinic visits at week 2/day 8 (+3/-0 days) and Week 6 / day 36, (+3/-3days). Subjects will receive a weekly televisit during Week 3 / day 15 (+3/-3), Week 4 / day 22 (+3/-3), and Week 5 / day 29 (+3/-3). |
GILBERT JENOURI; | 2023-10-30 |
| 177 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed Testofen (a specialised extract of Trigonella foenum-graecum (Fenugreek) seed) compared to placebo on post COVID-19 symptoms in otherwise healthy participants 18 years and over. |
AMANDA RAO; | 2023-10-25 |
| 178 | Antibody Response to Coronavirus Disease 2019 (COVID-19) Vaccination in Pregnant Woman and Transplacental Passage Into Cord Blood PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to study the correlation of maternal and cord blood level of Anti SAR-CoV. |
MONTREE BOONYAKITANON; | 2023-10-25 |
| 179 | Effect of Apollo Wearable on Symptoms Related to Post-acute Sequelae SARS-CoV-2 Infection (PASC) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine how Apollo wearable use impacts symptoms and quality of life following long COVID. |
BELINDA TAN; | 2023-10-23 |
| 180 | Real World Evaluation of COVID-19 Burden and Nirmatrelvir/Ritonavir in Taiwan Using National Health Insurance Research Database Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn about: – effects of living with COVID-19 and – how effective is nirmatrelvir-ritonavir in treating COVID-19. This is a study of two groups of COVID-19 patients in Taiwan. In Group 1 the below participants were included in the study: – Patients of all ages. – Patients who were confirmed to have COVID-19 infection between 01 January 2021 and 31 December 2021. – Cases of patients registered in the databases. In Group 2 the below participants were included in the study: – Participants who are 12 years or older. – … |
PFIZER | 2023-10-23 |
| 181 | Use and Effectiveness of COVID-19 Vaccines Using State Vaccine Registries and Insurance Claims Data Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to use vaccination information from state vaccine registries linked with HealthVerity insurance claims for the following: * to measure how effective the Pfizer-BioNTech vaccine is at preventing post-COVID conditions. * to understand characteristics of patients who are receiving COVID-19 vaccines. All patients whose information is kept unidentified in the HealthVerity database are eligible to be included for both aims of this study. |
PFIZER | 2023-10-23 |
| 182 | Booster Epidemiological Evaluation of Health, Illness and Vaccine Efficacy Study: Randomized Trial to Compare The Clinical Efficacy of Novavax Vs. MRNA COVID-19 2023-2024 Updated Vaccines Among Adults 18-49 and 50+ Years in The United States PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to find out how well two different 2023-2024 updated COVID-19 vaccines protect people from COVID-19 (the disease caused by the SARS-CoV-2 virus), and to determine if getting a 2023-2024 updated vaccine provides better protection from COVID-19 than not getting a vaccine. If the participant chooses to get a 2023-2024 updated COVID-19 vaccine as part of this study, they will have a 50/50 chance of receiving either the Novavax or Pfizer mRNA vaccine. If the participant decides not to get a 2023-2024 updated COVID-19 vaccine, … |
SARANG K. YOON; | 2023-10-16 |
| 183 | The Effects of Based-home High-resistance Inspiratory Muscle Training on Neurovascular Control, Blood Pressure, and Exercise Capacity in Patients With Post-COVID-19 Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with post-Covid-19 syndrome are at high risk of developing cardiovascular diseases 12 months after acute infection of COVID-19. We recently revealed that these patients have elevated muscular sympathetic nerve activity (MSNA), vascular dysfunction, impaired cardiac diastolic function, and reduced functional capacity. Considering that these outcomes are independent predictors of cardiovascular mortality, it is urgent to restore the cardiovascular health of these patients. High resistance inspiratory muscle strength training (IMST) at 75% of pressure inspiratory (PImax) performed at home (5 min/session, 5-7 times/week per 6 weeks) reduces the MSNA, … |
ALLAN KLUSER SALES; | 2023-10-16 |
| 184 | A Randomized, Double-Blinded, Placebo-Controlled, Pilot Study of The Combination of Valacyclovir + Celecoxib (IMC-2) for The Treatment of Post-Acute Sequelae of SARS-CoV-2 Infection in Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To explore the safety and efficacy of daily doses of celecoxib + valacyclovir in the treatment of patients with prolonged symptoms caused by COVID-19. |
LUCINDA BATEMAN; | 2023-10-15 |
| 185 | Disease Burden Transition of Mucormycosis in Hematologic Malignancies Population Across Covid 19 Era: A Single-center Comparative Analysis From China PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The project intends to carry out a retrospective study on the epidemiology, predisposing factors, clinical manifestations, diagnosis, treatment, prognosis and economic burden of mucormycosis in a Chinese single-center allogeneic hematopoietic stem cell transplantation population. The project was conducted at the Blood Diseases Hospital, Chinese Academy of Medical Sciences, which has rich experience in hematopoietic stem cell transplantation and has completed more than 3,000 cases of various types of HSCT, 400 allogeneic hematopoietic stem cell transplants per year, … |
INSTITUTE OF HEMATOLOGY & BLOOD DISEASES HOSPITAL CHINA | 2023-10-07 |
| 186 | CSP0010 FINDER® Instrument and FINDER® FLU A/B, RSV, SARS-CoV-2 Test Clinical Evaluation Protocol PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare the FINDER FLU A/B, RSV, SARS-CoV-2 Test to an FDA-cleared device. The study will utilize prospectively collected de-identified nasopharyngeal samples obtained from both pediatric and adult populations from subjects presenting with symptoms of respiratory illness. The main question it aims to answer are: • the study is to validate that the device intended use in terms that the device’s performance meets the criteria for substantial equivalence with a predicate and satisfies the statutory criteria for Clinical Laboratory Improvement Amendments (CLIA) waiver. |
BAEBIES | 2023-10-02 |
| 187 | A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in The Treatment of COVID-related Persistent Smell Loss PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss. This study aims to determine the efficacy of two at-home treatments, smell training and non-invasive trigeminal nerve stimulation. This study requires participants to conduct daily at-home treatment sessions, attend three in-person study visits at the MUSC Department of Psychiatry and Behavioral Sciences, and complete electronic questionnaires over the 12-week trial, and again at the six-month timepoint. Participants in this trial may benefit directly with an improvement in sense of smell. However, … |
BERNADETTE CORTESE; | 2023-10-02 |
| 188 | Nationwide Retrospective Observational Study of Herpes Zoster Associated Hospital Admissions in Italy PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: In Italy, the 2017-2019 National Immunization Plan recommended specific vaccinations for the elderly, defined as those 65 years old and older, and at-risk adults with age 50+ (adults presenting cardiovascular, respiratory, or metabolic diseases, immunodepression, etc.). However, the coverage target set by the Plan (50% for HZV in 2019) was not reached. Providing additional data on the incidence of HZ could improve the risks perception of the disease and the vaccination uptake. The present study will aim to describe a full picture of HZ associated hospital admissions in Italy, focusing on co-morbidities which induce reduced VZV-specific cell-mediated immunity response. Furthermore, … |
ANTONELLA MATTEI; | 2023-10-01 |
| 189 | The Impact of The COVID-19 Pandemic on The Patient in Need of An Intervention – COVID Surg III PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Mixed-method observational study: the impact of pandemic related changes in healthcare on quality of life and experiences with healthcare in Dutch patients undergoing surgery or another intervention during the covid pandemic (2020-2021). Phase 1: qualitative study to gain insight in relevant themes in Patient Reported Experiences Measures (PREMs) by conducting focus groups Phase 2: creating and validating a questionnaire based on themes identified in phase 1 Phase 3: questionnaire study among Dutch patients who underwent an intervention in 2020-2021 using the validated questionnaire of phase 2. The answers will be linked to data from national patients registries in surgery, cardiology, … |
SCHELTO KRUIJFF; | 2023-10-01 |
| 190 | A Retrospective Observational Non-Interventional Study (NIS) to Assess Patient Characteristics Among COVID-19 Patients Receiving Treatment With Nirmatrelvir/Ritonavir (PAXLOVIDTM) in Morocco PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to collect information on the: – general information of a group of people such as their age, sex, and other facts. – clinical information of the patients such as any other illness before having COVID 19. In adult patients with COVID-19 who have been prescribed nirmatrelvir and ritonavir treatment. This study will be conducted in Morocco. The study will capture information of the adult COVID-19 outpatients and inpatients who have been prescribed nirmatrelvir, … |
PFIZER | 2023-10-01 |
| 191 | Prevalance of Cardiovascular Complications in Children With COVID 19 in Assuit University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Abstract: In December 2019, coronavirus disease 2019 (COVID-19) was first described in Wuhan, China, in patients complaining of flulike symptoms.1 The virus was isolated and identified as a … |
OMAR ATIF ABD ELHALEEM; | 2023-10-01 |
| 192 | Safety, Reactogenicity and Immunogenicity Study of The Vector Vaccine GamCovidVac-M for The Prevention of Coronavirus (COVID-19) Infection Caused By The SARS-CoV-2 Virus With Altered Antigenic Composition With Participation of 12-17 Years Old Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Safety, reactogenicity and immunogenicity study of the vector vaccine GamCovidVac-M for the prevention of coronavirus (COVID-19) infection caused by the SARS-CoV-2 virus with altered antigenic composition with participation of 12-17 years old volunteers. |
GAMALEYA RESEARCH INSTITUTE OF EPIDEMIOLOGY AND MICROBIOLOGY HEALTH MINISTRY OF THE RUSSIAN FEDERATION | 2023-10-01 |
| 193 | Effects of ATDCS Stimulation of The Dorsolateral Prefrontal Cortex on Cognitive Functions and The Parietal Memory Network, Default Mode Network in Patients Presenting Cognitive Symptoms After Covid-19 Infection: A Controlled Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the effects of bilateral stimulation of the dorsolateral prefrontal cortex (DLPFC) with active tDCS (transcranial direct stimulation/transcranial direct stimulation) on neurocognitive (memory and executive) functions in patients with Covid-19 infection and subjective cognitive complaints, as well as resting-state fMRI In the case of dfMRI, it is aimed to examine the default mode network (DMN) and parietal memory network (PMN) inter- and intra-network connectivity alterations and the hippocampal region connectivity alterations and contribute to the relevant literature. |
LUTFU HANOGLU; | 2023-10-01 |
| 194 | Safety, Reactogenicity and Immunogenicity Study of The Vector Vaccine GamCovidVac for The Prevention of Coronavirus (COVID-19) Infection Caused By The SARS-CoV-2 Virus With Altered Antigenic Profile With Participation of Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Occurrence of serious adverse events (SAEs) … |
GAMALEYA RESEARCH INSTITUTE OF EPIDEMIOLOGY AND MICROBIOLOGY HEALTH MINISTRY OF THE RUSSIAN FEDERATION | 2023-10-01 |
| 195 | Exercise As A Therapeutic for Those Diagnosed With Post-acute Sequelae of Covid-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic severely impacted the medical system both directly but also through incomplete recovery from the virus in the form of post-acute sequelae of COVID-19 (PASC). PASC affects at least 9.6 million individuals as of May 2022 and continues to affect many more. PASC is a multisystem disorder often presenting with mental fog, dyspnea on exertion, and fatigue among other symptoms. The etiology of PASC is uncertain but theories include direct cytotoxicity, dysregulated immune responses, endotheliitis associated with microthrombi, eNOS uncoupling, and myocardial fibrosis with impaired ventricular compliance. To date, … |
SIDDARTHA ANGADI; | 2023-10-01 |
| 196 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this study is to find out if rehabilitation exercise can help people who have long COVID. Participants will be randomized by chance to receive either aerobic exercise or breathing exercise (combined with stretches). Participants will be guided and supported in completing a tailored, 6-week home exercise program to be performed 5 – 6 days a week, prescribed and supervised by rehabilitation therapists. Participants will perform breathing exercises, which will be supervised by an occupational therapist. The focus of Aim 1 is to determine feasibility of implementing RESToRE in long COVID. |
ANNAMARIA R. NORWEG; | 2023-10-01 |
| 197 | Phase 3, Multi-center, Observer-blind, Randomized, Controlled Study to Evaluate The Immunogenicity and Safety of Monovalent Omicron XBB.1.5 Vaccine Administered As A Booster Dose to Adults Who Previously Received COVID-19 Vaccine Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the immunogenicity and safety of SCB-2023B monovalent Omicron XBB.1.5 vaccine compared to the prototype SCB-2019 vaccine in participants previously vaccinated with 3 doses of inactivated COVID-19 vaccine ≥6 months prior to enrollment. |
CLOVER BIOPHARMACEUTICALS AUS PTY | 2023-10-01 |
| 198 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ESSOR is a double-blind, placebo-controlled study of the orally-administered antiviral and inflammation-controlling LAU-7b for the treatment of adults with Long COVID and moderate to severe symptoms. |
LAURENT PHARMACEUTICALS | 2023-09-30 |
| 199 | A Phase II Randomized, Double-blind Study to Evaluate The Safety, Neutralizing Activity and Efficacy of AZD3152 for Pre-exposure Prophylaxis of COVID-19 in Participants Having An Increased Risk for Inadequate Response to Active Immunization (NOVELLA) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: AZD3152, a single mAb, is being developed to have broad neutralizing activity across known SARS-CoV-2 variants of concern for pre-exposure prophylaxis of COVID-19. The aim of the Phase II study is to evaluate the safety, neutralizing activity and efficacy of AZD3152 for pre exposure prophylaxis of COVID-19 |
ASTRAZENECA | 2023-09-30 |
| 200 | A Phase 1, Multicenter, Randomized, Double-blind, Placebo- Controlled, Parallel Group Study to Evaluate The Safety of RQ-01 in SARS-CoV-2 Positive Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a first in human clinical study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of RQ-01. Adult patients who have tested positive for SARS-CoV-2 virus, have mild symptom(s) of COVID-19 disease, and who are at low risk for developing moderate or severe COVID-19 disease are welcome to participate. The main questions this study aims to answer are: 1. What is the safety profile of RQ-01? 2. What is the reduction in SARS-CoV-2 ribonucleic acid (RNA) shedding after administration of RQ-01? 3. How effective is RQ-01 versus placebo in reducing COVID-19 symptoms? After providing informed consent, … |
RED QUEEN THERAPEUTICS | 2023-09-27 |
| 201 | Immunogenicity of Concomitant Administration of Omicron-containing COVID-19 Vaccines With Influenza Vaccines : In-depth Immunogenicity Analysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal is to evaluate the in-depth immunogenicity analysis (including B-cell and T-cell response) of coadministration of a omicron-containing COVID-19 vaccine and influenza vaccine among healthy adults during 2023-24 season. |
MIN JOO CHOI; | 2023-09-25 |
| 202 | SARS-COV-2 (Virus Responsible of COVID-19) Reinfection and Multisystem Inflammatory Syndrome in Children (MIS-C) Risk: Matched Case-control Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter, international, non interventional, retrospective study about SARS-CoV-2 and Multisystem Inflammatory Syndrome (MIS-C) reinfection risk in children. |
NAIM OULDALI; | 2023-09-22 |
| 203 | Immunobridging Study: Immunogenicity and Safety of INAVAC (Vaksin Merah Putih – UNAIR SARS-CoV-2 (Vero Cell Inactivated)) As Heterologue Booster in Adolescent Subjects in Indonesia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label trial. There will only be 1 group in the study. All subjects will receive INAVAC vaccine and be followed for 6 months. The vaccine will be administered intramuscularly. This study will be started after the interim analysis of the phase III INAVAC trial in adolescent. This study will have two interim and one full analysis reports. |
DR SOETOMO GENERAL HOSPITAL | 2023-09-19 |
| 204 | CPAP Therapy Through A Helmet or A Full Face Mask in Patients With Acute Hypoxemic Respiratory Failure: A Comparative, Cross-over, Physiological Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Observational and randomized trials have demonstrated the high effectiveness of non-invasive helmet ventilatory support, demonstrating a reduction in intubation rate mortality compared with high-flow and standard oxygen therapy. Some pilot physiological studies have shown physiological benefits of helmets compared to the oronasal mask for non-invasive ventilation. The purpose of the study is to compare markers of patient self-inflicted lung injury (P-SILI), patient’s comfort, work of breathing, gas exchange, … |
ANDREY I YAROSHETSKIY; | 2023-09-19 |
| 205 | Role of OMT in The Management of The Persistent Post-COVID-19 Symptoms – A Pilot Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to determine the feasibility of conducting a large-scale study on the effect of using osteopathic manipulative treatment (OMT) to treat patients with post-COVID-19 symptoms. The main questions it aims to answer are: 1. Is it feasible to conduct a large-scale study of the effect of OMT on patients with post-COVID-19 symptoms (based on how many patients agree to participate and how many complete the study)? 2. How much change in patients’ post-COVID-19 symptom severity, quality of life, … |
BRIAN F DEGENHARDT; | 2023-09-18 |
| 206 | A Phase I Study of The Safety and Immunogenicity of The Recombinant, Live-Attenuated, Bovine/Human Parainfluenza Virus Vector Vaccine Expressing The 6P-Prefusion-Stabilized Version of The SARS-CoV-2 Spike Protein, Administered in Two Sequential Doses As Nasal Spray to Adults 18 to 50 Years of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase 1 clinical trial will evaluate the safety and immunogenicity of an intranasal vaccine candidate, a recombinant, live-attenuated, bovine/human parainfluenza virus vector vaccine expressing the 6-P prefusion-stabilized version of the SARS-CoV-2 spike protein. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2023-09-18 |
| 207 | Randomized Study of The Immunogenicity and Duration of Antibody Response Against Circulating SARS-CoV-2 Variant and Influenza Viruses Following Concomitant Versus Sequential Administration of MRNA COVID-19 Vaccine and Quadrivalent Cell Culture-based Influenza Vaccine Among Children and Adults PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, randomized randomized immunologic study of response to influenza and SARS-CoV-2 vaccination across four of the US Influenza Vaccine Effectiveness (Flu VE) Network study sites. |
MICHAEL WHITE; | 2023-09-15 |
| 208 | ECMO Braile Biomédica® in COVID-19 Patients Post-market Clinical Trial to Verify The Performance of The ECMO System PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Retrospective data collection to evaluate the gas transfer capacity of the Braile Biomédica® OxyPrime® ECMO BRCoating® Membrane Oxygenator in COVID-19 patients during the pandemic. |
VITOR S BARZILA; | 2023-09-14 |
| 209 | A Study to Evaluate The Efficacy and Safety of VYD222 for Prevention of COVID-19 (CANOPY) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: A study to investigate the prevention of COVID-19 with VYD222 in adults with immune compromise and in participants aged 12 years or older who are at risk of exposure to SARS-CoV-2 |
INVIVYD | 2023-09-08 |
| 210 | A Phase II, Randomized, Double-blind, Multi-centre Trial to Evaluate The Safety and Immunogenicity of BIMERVAX® When Coadministered With Seasonal Surface Antigen, Inactivated, Adjuvanted Influenza Vaccine (SIIV) in Adults Older Than 65 Years of Age Fully Vaccinated Against COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase II, randomized, double-blind, multi-centre trial to evaluate the safety and immunogenicity of BIMERVAX® when coadministered with seasonal surface antigen inactivated adjuvanted influenza vaccine (SIIV) in adults older than 65 years of age fully vaccinated against COVID-19. In this study approximately 300 adults aged 65 or older will be enrolled and followed for 1 month after study treatment. Safety and immunogenicity of all participants will be assessed. |
HIPRA SCIENTIFIC S L U | 2023-09-04 |
| 211 | Evolution of Respiratory Function in Lung Transplant Patients With Moderate to Severe SARS-Cov-2 Infection, Single-center Retrospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The SARS-Cov-2 infection pandemic has caused a large number of acute respiratory failures and deaths across the world. Certain factors have been identified as associated with a higher risk of developing a severe form and dying. Immunosuppression has been identified as a risk factor for progressing to a severe form. Lung transplant patients were particularly vulnerable during this period, with a high frequency of respiratory compromise, sometimes progressing towards acute respiratory distress syndrome and, at a later stage, … |
CHARLES AMBROISE TACQUARD; | 2023-09-04 |
| 212 | A Phase III Multinational, Multicenter, Observer-Blinded, Randomized, Active-Controlled Trial to Evaluate The Immunogenicity and Safety of The Preventive COVID-19 Vaccine AdCLD-CoV19-1 OMI Administered As A Booster to Adults Aged 19 Years Old and Above PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The immunogenicity and safety of AdCLD-CoV19-1 OMI (5.0×10^10 VP (0.5 mL)/dose/Vial) administered as a booster in healthy adults aged 19 years old and above will be evaluated. Outcome assessment will be performed in comparison with Comirnaty Bivalent. |
CELLID | 2023-09-01 |
| 213 | Evaluation of The Safety and Efficacy of Azvudine and Paxlovid in The Treatment of Hospitalized Patients With COVID-19 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In this retrospective study, we aimed to evaluate the clinical efficacy and safety of two antiviral drugs on COVID-19 and inpatients with existing complications in the First Affiliated Hospital of Shandong First Medical University. In addition, we also explored a key issue. Is the combined treatment effect of two antiviral drugs, Paxlovid and Azvudine, better than the use of a single drug? |
XIAO LI，MD; | 2023-09-01 |
| 214 | Etiology Analysis of Chronic Cough After COVID-19 Infection and Research on The Efficacy of ICS or ICS/LABA PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study collected 600 patients, evaluated whether patients had airway hyperreactivity, airway inflammation, specific types and allergic reactions, comprehensively analyzed and classified the causes of chronic cough in patients, and evaluated and compared the improvement of cough symptoms and quality of life after ICS or ICS/LABA treatment. |
JUAN JIANG; | 2023-09-01 |
| 215 | Digital Health Literacy on COVID-19 for All: Co-creation and Evaluation of Interventions for Ethnic Minorities and Chinese People With Chronic Illnesses in Hong Kong PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: During the pandemic, people are anxious for information, and electronic platform serves the purpose of having first-hand health information and spreading it to massive population within a short time. However, the source and credibility of the influx of online information are hard to be verified. Digital health literacy (DHL) is the capacity to access, understand, evaluate, and apply health information from electronic sources, which is an important attribute that everyone should possess. Recent studies from our group in Hong Kong have shown that, during the COVID-19 pandemic, DHL is an issue facing people of all ages, especially ethnic minorities (EMs), … |
ANGELA LEUNG; | 2023-09-01 |
| 216 | Intradermal Administration of A COVID-19 MRNA Vaccine in Elderly PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Respiratory tract infections, e.g. caused by SARS-CoV-2, disproportionately affect elderly. Vaccination has shown to be the most cost-effective approach to prevent infections. However, older adults often fail to induce a potent immune response to vaccines, as was also seen recently for COVID-19 mRNA vaccines. This is likely due to immune dysfunction as a consequence of aging. To potentiate a stronger immune response, vaccine administration into the papillary dermis (intradermal, … |
HANS DE GRAAF; | 2023-09-01 |
| 217 | COVID-19 Vaccination Willingness in Older Adults Based on Self-determination Theory PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction: The COVID-19 vaccine is an effective measure for preventing and controlling COVID-19 epidemics, and the World Health Organization lists older adults as a high-priority group for COVID-19 vaccination. However, the willingness of older people to be vaccinated against COVID-19 remains an important issue in achieving herd immunity. We investigated the effectiveness of a COVID-19 vaccine intervention for older adults, … |
JING-SHAN DENG; | 2023-09-01 |
| 218 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating potential interventions for PASC-mediated cognitive dysfunction. The hypothesis is that PASC associated dysfunction in cognitive domains, such as executive function and attention, may be improved by interventions that selectively focus on enhancing those domains. |
DUKE UNIVERSITY | 2023-09-01 |
| 219 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy, Safety, Tolerability and Pharmacokinetics of SNS812 in Participants With Mild to Moderate COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View |
ONENESS BIOTECH | 2023-09-01 |
| 220 | A Randomized, Double-blind, Placebo-controlled Phase I Clinical Trial to Evaluate The Safety and Tolerability of Omicron BA.4/5-Delta Strain Recombinant Novel Coronavirus Protein Vaccine (CHO Cells) in People Aged 18 Years and Above PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety of Omicron BA.4/5-Delta strain recombinant novel coronavirus protein vaccine (CHO cells) after vaccination in people aged 18 and over. It is planned to screen 100 subjects who are 18 years old and above and more than 6 months since the last new coronavirus infection or new coronavirus vaccine. All subjects collected venous blood before vaccination, 14 days, 3 months, and 6 months after vaccination for immunological detection of neutralizing antibody of the new coronavirus prototype strain, Delta strain and Omicron strain (BA.4/5, XBB); … |
JUNSHI ZHAO; | 2023-09-01 |
| 221 | A Culturally Relevant Communication and Support Plan to Ensure Access to and Use of Covid-19 Testing for Francophone African Born Immigrants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test the effectiveness of a culturally sensitive COVID-19 testing intervention designed for Francophone (French speaking) African Born Immigrants (FABI) . The main question this study aims to answer is whether or not a a culturally sensitive COVID-19 educational pamphlet added to the home-based test will improve testing rates compared to receiving a standard home-based test alone. |
TEXAS WOMAN’S UNIVERSITY | 2023-09-01 |
| 222 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating potential interventions for PASC-mediated cognitive dysfunction. The hypothesis is that PASC-associated dysfunction in cognitive domains, such as executive function and attention, … |
DUKE UNIVERSITY | 2023-09-01 |
| 223 | Safety, Reactogenicity and Immunogenicity Study of The Drug Sputnik Lite for The Prevention of Coronavirus (COVID-19) Infection Caused By The SARS-CoV-2 Virus With Altered Antigenic Composition With Participation of Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Safety, reactogenicity and immunogenicity study of the drug Sputnik Lite for the prevention of coronavirus infection caused by the SARS-CoV-2 virus with altered antigenic composition with participation of adult volunteers. |
GAMALEYA RESEARCH INSTITUTE OF EPIDEMIOLOGY AND MICROBIOLOGY HEALTH MINISTRY OF THE RUSSIAN FEDERATION | 2023-09-01 |
| 224 | Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The efficacy of natural foods such as freeze-dried mare’s milk (Saumal) in post-COVID syndrome therapy has not been studied. The literature review has shown that researchers have focused more on evidence-based medications and less on natural products. Some raw foods, such as freeze-dried mare’s milk, contribute to forming complete immune complexes and have antioxidant, membrane stabilizing, and antiviral effects. The use of Saumal proved its effectiveness in patients suffering from chronic hepatitis C. After 4 weeks of using freeze-dried mare’s milk, … |
VILDAN INDERSHIYEV; | 2023-09-01 |
| 225 | A Dose-escalation, Double-blinded, Randomized, Placebo-controlled Phase 1 Study to Assess The Safety, Reactogenicity, and Immunogenicity of A SARS-CoV-2 Booster Vaccine (LEM-mR203) in Healthy Adults Aged at 19 to 55 Years PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: The LEM-mR203 is a mRNA vaccine candidate using Lemonex’s DDS (Drug Delivery System) named DegradaBALL, and is to be evaluated as a booster vaccine for the prevention of COVID-19 … |
IN JIN JANG; | 2023-09-01 |
| 226 | Mesenchymal Stem Cell Exosomes for The Treatment of COVID-19 Positive Patients With Acute Respiratory Distress Syndrome And/or Novel Coronavirus Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Novel coronavirus pneumonia (NCP) and acute respiratory distress syndrome (ARDS) are both associated with the prevailing upper respiratory tract infections caused by the RNA-containing SARS-CoV2 virus of the genius Betacoronavirus of the Coronaviridae family. As both the viral infiltration and infection progress, the host immune system response can be one of a rapidly developing fatal cytokine storm. In the ARDS or NCP ensuing progression, the patient often succumbs to the effects of the hyper pro-inflammatory response, hence contributing to the associated increased mortality as a result of the cytokine storm and associated pathogenesis. |
AVEM HEALTHCARE | 2023-09-01 |
| 227 | Pain, Physical Activity, Posture and Quality of Life in Individuals With Idiopathic Scoliosis Who Have Had COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: It is not known to what extent the COVID-19 virus affects individuals with scoliosis during the prolonged COVID-19 pandemic. Therefore, in this study it was aimed to comparatively investigate pain severity, posture disorders that can be assessed by artificial intelligence, physical activity levels and quality of life in individuals with idiopathic scoliosis with and without COVID-19. |
MERVE NUR YÜKSEL; | 2023-09-01 |
| 228 | Chest Mobility, Cough Strength, Muscle Strength, Physical Activity and Quality of Life in Parkinson’s Patients Who Have Had COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To comparative pain intensity, chest mobility, cough strength, muscle strength, physical activity levels and quality of life in Parkinson’s patients with post-COVID-19 and without post-COVID-19 was aimed in current study. Knowledge in the literature regarding this topic is still obscure. |
MERVE ŞAHİN; | 2023-09-01 |
| 229 | A Real-world Study：Disease Outcome and Safety of JT001 in Patients With Coronavirus Disease 2019 (COVID-19) PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Real-world disease outcomes and safety in patients with mild to moderate COVID-19 treated with JT001 |
SHANGHAI VINNERNA BIOSCIENCES | 2023-08-31 |
| 230 | Cohort Survey on Non-Acute Safety in Persons With Underlying Diseases Who Are Considered to Be at High Risk of Severe COVID-19 By Using Vaccination Information PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to assess serious adverse events associated with hospitalizations in the non-acute phase after vaccination with the mRNA-1273 vaccine in persons with underlying diseases who are considered to have a high risk of severe exacerbation of COVID-19. |
MODERNATX | 2023-08-31 |
| 231 | A Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate The Efficacy and Safety of Novel Coronavirus Broad-spectrum Neutralizing Antibody SA55 Injection in The Treatment of Mild/Moderate COVID-19 Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluating the efficacy and safety of SA55 injection in light/medium COVID-19 patients |
GUANG NING; | 2023-08-31 |
| 232 | A Phase 2/3, Randomized, Double-Blind Study to Evaluate The Safety and Immunogenicity of Different Booster Dose Levels of Monovalent SARS-CoV-2 RS Vaccines in Adults ≥ 50 Years Previously Vaccinated With COVID-19 MRNA Vaccines PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2/3, randomized, double-blind study to evaluate the safety and immunogenicity of different booster dose levels of the monovalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant (r) spike (S) protein nanoparticle (SARS-CoV-2 rS) vaccines with Matrix-M™ adjuvant (NVX-CoV2373 [prototype Wuhan vaccine with Matrix-M adjuvant] or NVX-CoV2601 [Omicron XBB.1.5 subvariant vaccine with Matrix-M adjuvant]). |
ROBERT MUTTERPERL; | 2023-08-30 |
| 233 | COVID-19 Vaccination Hesitancy in Adults With Sickle Cell Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test an COVID-19 vaccination information video in adults with sickle cell disease. The main questions it aims to answer are why are some adults with sickle cell disease hesitant to receive COVID-19 vaccination and whether a COVID-19 vaccination information video tailored for people with sickle cell disease will reduce vaccine hesitancy. Participants will complete a brief survey before and after watching a short video with information on vaccine safety, efficacy, and the greater impact of COVID-19 infection on people with sickle cell disease. |
JOHN J. STROUSE; | 2023-08-23 |
| 234 | A Phase 2/3 Open-Label Study to Evaluate The Safety and Immunogenicity of An XBB.1.5 (Omicron Subvariant) SARS CoV-2 RS Vaccine Booster Dose in Previously MRNA COVID 19 Vaccinated and Baseline SARS CoV 2 Seropositive COVID-19 Vaccine Naïve Participants PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2/3 open-label study to evaluate the safety and immunogenicity of a booster dose of the XBB.1.5 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant (r) spike (S) protein nanoparticle vaccine (SARS-CoV-2 rS) adjuvanted with Matrix-M™ in previously mRNA COVID-19 vaccinated adult participants ≥18 years of age and baseline SARS CoV-2 seropositive COVID-19 vaccine naïve participants ≥18 years of age. |
HARRY STUDDARD; | 2023-08-22 |
| 235 | A Comparative Evaluation of Specimen Adequacy of A Traditional Nasopharyngeal Swab As Compared to Nasopharyngeal Saline Wash, Saliva, and Serum to Test for Respiratory Viruses and Antibody Response PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Respiratory tract infections (RTIs) are prevalence community diseases and is the third leading cause of death worldwide. Rapid diagnosis of RTIs is essential as it drives decision points such as treatment, disposition, and containment. According to recent CDC (The Centers for Disease Control and Prevention) updates, nasopharyngeal swabbing is the preferred method of specimen collection for most RTIs such as SARS-COV-2. This process is invasive and traumatizing for patients as it requires probing (20 seconds) of the posterior nasopharynx with swab applicator. In some cases, … |
THANH NGUYEN; | 2023-08-21 |
| 236 | Provide Pre-approval Single-patient Expanded Access (Compassionate Use) of VYD222 for Patients With Symptomatic COVID-19 Refractory to Other Treatments Related Papers Related Patents Related Grants Related Experts View Highlight: Provide pre-approval single-patient Expanded Access (Compassionate Use) of VYD222 for patients with symptomatic COVID-19 refractory to other treatments. |
INVIVYD | 2023-08-18 |
| 237 | A Phase 3, Randomized, Double-Blinded Study to Evaluate The Safety and Immunogenicity of Omicron Subvariant and Bivalent SARS-CoV-2 RS Vaccines in Adolescents Previously Vaccinated With MRNA COVID-19 Vaccines PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 3, Randomized, Double-Blinded Study to Evaluate the Safety and Immunogenicity of Omicron Subvariant and Bivalent SARS-CoV-2 rS Vaccines in Adolescents Previously Vaccinated with mRNA COVID-19 Vaccines. |
DAVID BENSON; | 2023-08-16 |
| 238 | A PHASE 2/3 PROTOCOL TO INVESTIGATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF BNT162b2 RNA-BASED VACCINE CANDIDATES FOR SARS-CoV-2 NEW VARIANTS IN HEALTHY INDIVIDUALS PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical protocol is to learn about the safety, tolerability, and immunogenicity of new BNT162b2 RNA-based vaccine candidates targeting new variants of SARS-CoV-2 in healthy people. Substudy A: * This study will evaluate the safety, tolerability, and immunogenicity of BNT162b2 (Omi XBB.1.5) given as a single 30 µg dose, * in people who are 12 years of age and older, * who previously received at least 3 doses of a US-authorized mRNA COVID-19 vaccine, … |
BIONTECH SE | 2023-08-10 |
| 239 | A Randomized, Double-Blind, Active-controlled Phase Ⅲ Clinical Trial to Evaluate The Immunogenicity and Safety of One Booster Dose of Trivalent COVID-19 Vaccine (Vero Cell), Inactivated in Healthy People in Colombia PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, active-controlled phase Ⅲ clinical trial.The purpose of this study is to evaluate the immunogenicity and safety of one booster dose of trivalent COVID-19 vaccine (vero cell), inactivated, prototype strain, delta strain and omicron strain in healthy people aged 3 years old and above and have completed two or three doses of CoronaVac® in Colombia. |
ANDRÉS CADENA; | 2023-08-10 |
| 240 | A Phase II Clinical Trial to Evaluate The Immunogenicity and Safety of SCTV01E-2 (COVID-19 Beta/Omicron (BA.1/BQ.1.1/XBB.1) Variants S-Trimer Vaccine) in Population Previously Vaccinated With MRNA COVID-19 Vaccine PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a phase Ⅱ clinical trial to evaluate the safety and immunogenicity of SCTV01E-2 in people of different ages who had been vaccinated with COVID-19 vaccines. A total of at least 600 subjects aged 3 years and older who were previously vaccinated with domestically licensed SARS-CoV-2 vaccines with recommended doses and immunization schedules are planned to be enrolled. Group A included 400 patients aged 18 years and above, and group B included 200 patients aged 3-17 years. |
SINOCELLTECH | 2023-08-10 |
| 241 | Exploratory, First Time in Human (FTIH), Observer-blind, Randomized, Controlled Study to Evaluate Safety, Reactogenicity and Immunogenicity of Various Doses of GlaxoSmithKline Biologicals SA’s (GSK) Investigational Omicron Variant S Glycoprotein (mRNA-CR-04) Vaccine When Administered Intramuscularly in Healthy Adults 18 to 49 Years of Age PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety, reactogenicity and immune responses of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA-CR-04 vaccine construct when administered in healthy adults previously vaccinated with SARS-CoV-2 mRNA vaccines. |
PATRICK R YASSINI; | 2023-08-07 |
| 242 | Risk Factors for Severe Disease in Hospitalized Patients With COVID-19 and The Effect PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to explore the factors that can affect the development of severe cases in hospitalized patients with COVID-19, including basic diseases, laboratory parameters, and clinical manifestations; In addition,to explore whether Azvudine can reduce the mortality of hospitalized patients with COVID-19. |
FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIVERSITY | 2023-08-05 |
| 243 | An Analysis of Changes in Out-patient Visits in Taiwan During The Time of Global COVID-19 Pandemic PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic becomes a global challenge. This study aims to analyze the possible changes in out-patient visits during the time of COVID-19 pandemic between January and June, 2020, compared with the same period in 2019, and the impact of the related healthy policies. |
WAN-CHING LIEN; | 2023-08-01 |
| 244 | Leveraging Community Health Workers to Combat Health Misinformation in Haiti, Malawi, and Rwanda PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Partners In Health (PIH), in collaboration with Harvard Medical School, aims to develop and evaluate an SMS-based intervention for Community Health Workers (CHWs) to combat COVID-19 and mental health-related misinformation in Haiti, Rwanda, and Malawi. The study involves three aims: identifying locally relevant misinformation through a card-sorting exercise with CHWs, developing targeted messages through cognitive interviewing, and evaluating the effectiveness of SMS-based educational message dissemination via a randomized controlled trial. The evaluation will assess the impact on public health practices, knowledge and attitudes among CHWs, and knowledge and attitudes among community members. |
BETHANY HEDT-GAUTHIER; | 2023-08-01 |
| 245 | Phase 3, Multi-center, Observer-blind, Randomized, Controlled Study to Evaluate The Immunogenicity and Safety of SCB-2023 Vaccine Administered As A Booster Dose to Adults Who Previously Received COVID-19 Vaccine PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the immunogenicity and safety of SCB-2023 trivalent vaccine compared to the prototype SCB-2019 monovalent vaccine in participants previously vaccinated with 3 doses of inactivated COVID-19 vaccine ≥6 months prior to enrollment. |
CLOVER BIOPHARMACEUTICALS AUS PTY | 2023-08-01 |
| 246 | Immunogenicity and Safety of An Inactivated SARS-CoV-2 Vaccine Coadministered With Varicella Vaccine and Measles, Mumps and Rubella Combined Vaccine in Shanghai, China: A Non-inferiority, Open-label, Randomised, Controlled, Phase 4 Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Eligible participants were randomly assigned (1:1:1), using block randomization stratified, to either 3 groups. Group 1 will be immunized inactivated SARS-CoV-2 vaccine and varicella vaccine in day 0 followed by measles-mumps-rubella vaccine(MMR) in day 28. Group 2 will be immunized varicella vaccine in day 0 followed by SARS-CoV-2 vaccine and MMR in day 28. Group 3 will be immunized inactivated SARS-CoV-2 vaccine in day 0 followed by MMR and varicella vaccine in day 28. Vaccines were administered 28 days apart, with blood samples taken on day 0 and day 28 before vaccination, … |
HUANG ZHUOYING; | 2023-08-01 |
| 247 | A Clinical Evaluation of The Safety and Efficacy of Randomized Placebo Versus The 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression (the ACLR8-LR Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A clinical study to assess the efficacy and safety of oral tafenoquine compared to placebo in patients with mild to moderate COVID 19 disease and low risk of disease progression (the ACLR8-LR study). |
60P AUSTRALIA PTY | 2023-08-01 |
| 248 | Research on The Intervention, Prognosis and Mechanism of Novel Coronavirus Infection in Patients With Underlying Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to explore the influence of Covid-19 infection and risk factors of severe outcomes in vulnerable population including patients with chronic liver disease, malignant tumor, autoimmune disease, medical staff. The main questions it aims to answer are: 1. The clinical characteristics of vulnerable population after Covid-19 infection. 2. Risk factors for severe illness in vulnerable groups after infection with the Covid-19. 3. The impact of Covid-19 infection on the progression of underlying diseases. Information of participants will be collected such as gender, age, underlying diseases, medication status, vaccination status, … |
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY | 2023-08-01 |
| 249 | A Phase 2, Non-inferiority, Open-label, Randomized Controlled Study to Evaluate The Immunogenicity and Safety of Comvigen (Bivalent) Vaccine As A Booster Dose in Adults Who Have Received A Previous Booster Dose of An Approved COVID-19 Vaccine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the safety, reactogenicity and immunogenicity of a single dose of Comvigen (Bivalent, ChulaCov19 BNA159.2) vaccine or BIVALENT Pfizer/BNT vaccine as a booster among healthy males and non-pregnant females aged 18-64 years after receiving a previous booster dose of any approved mRNA COVID-19 vaccine for more than 3 months. The results of Combiven will be compared to BIVALENT Pfizer/BNT vaccine. |
WATSAMON JANTARABENJAKUL; | 2023-08-01 |
| 250 | Exploring Gas Transfer and The Utility of Dynamic Chest Radiography in Long Covid Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to identify if breathless patients with Long COVID have reduced transfer factor on pulmonary function testing and if the degree of transfer factor reduction is correlated with the symptom severity and physiological ability to exercise. We will also investigate whether a new type of X-ray called a dynamic chest X-ray can identify perfusion abnormalities and whether these correlate with differences in diffusion capacity measured on a pulmonary function test. |
LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST | 2023-08-01 |
| 251 | Prospective Randomized Trial of Everolimus Replacing MMF/MP Acid By The RECOVAC Consortium to Increase VACcine Response in Kidney Transplant Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: To investigate whether replacement of MMF/MPA by everolimus in kidney transplant recipients results in superior immunogenicity of COVID-19 vaccination as measured by neutralizing antibody titer against the Omicron BA.5 strain. Trial design: Multicentre, open-label randomized controlled clinical trial, for a duration of at least 10 weeks with an optional extension to 18 weeks. Trial population: Kidney transplant recipients, 18 years or older, who are at least 6 months after transplantation, with a functioning kidney transplant, using MMF/MPA in combination with at least one other immunosuppressant including a calcineurin inhibitor (CNI), … |
JAN-STEPHAN F SANDERS; | 2023-08-01 |
| 252 | Characteristics of Blood Glucose Variability in Patients With Type 2 Diabetes Mellitus Complicated With COVID-19 and Its Effect on The Prognosis of The Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: using intermittently scanned continuous glucose monitoring (isCGM) to clarify the characteristics of blood glucose variability parameters in T2DM patients with NCP, guide the formulation of reasonable clinical treatment measures and make timely and reasonable adjustments, improve the prognosis of patients, shorten the length of hospital stay, … |
KUANXIAO TANG; | 2023-08-01 |
| 253 | Monitoring SARS-CoV-2 Vaccines and COVID-19 Related Outcomes in Individuals With Multiple Myeloma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic has had an outsized impact on individuals with underlying social and medical vulnerability, leading to increased rates of severe disease, hospitalization, and death in these groups. Participants with underlying immune compromise, such as those with multiple myeloma, represent one such group. The advent of vaccines against SARS-CoV-2 has significantly limited morbidity and mortality across all groups, but the effectiveness of vaccination in individuals who are less likely to mount sufficient antibody response is uncertain. For this reason, booster vaccines have been recommended for those with underlying immune compromise. However, … |
WILLIAM WOOD; | 2023-08-01 |
| 254 | A Case-Control Study on The Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is; To Assess the association between periodontal health and Matrix metalloproteinase-8 (MMP-8) level in Gingival Crevicular Fluid (GCF) in post COVID-19 patients. |
RANDA NIDAL ALZOUBI; | 2023-08-01 |
| 255 | Randomized Observer-Blinded Phase 2 Trial of COVID-19 Booster With GEO-CM04S1 or MRNA Vaccine in Patients With Chronic Lymphocytic Leukemia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase II trial compares the effect of the GEO-CM04S1 vaccine with the current standard of care vaccine in preventing COVID-19 infections in patients with chronic lymphocytic leukemia (CLL). The GEO-CM04S1 vaccine uses a modified vaccinia virus (MVA) backbone that may be more effective at boosting COVID-19 immunity in patients with poor immune responses. MVA strongly induces T cell expansion (infection fighting blood cells) even in the background of a suppressed immune system, which is the case in the targeted CLL patient population. Using the GEO-CM04S1 vaccine may be more effective at preventing COVID-19 infection in patients diagnosed with CLL. |
ALEXEY V DANILOV; | 2023-08-01 |
| 256 | Mitigating Mental and Social Health Outcomes of COVID-19: A Counseling Approach PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to develop a comprehensive mental health counseling program purposed to address the social determinant of health impacts of the coronavirus disease of 2019 (COVID-19). The main questions the investigators aim to answer are: 1) What are the mental and social determinant of health impacts of a COVID-19 diagnosis, and 2) What are the impacts of a counseling program implemented to address those impacts? Participants will participate in individual interviews, attend individual and group counseling, and be provided resources related to their social determinants of health needs. |
NEW MEXICO STATE UNIVERSITY | 2023-08-01 |
| 257 | Prediction of Conversion From Vv-ECMO to Va-ECMO in COVID-19 Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In December 2019, cases of a novel lung disease, later referred to as COVID-19, were first reported in China. The virus SARS-CoV-2 was identified as the causative agent. Due to the sharp increase in the number of cases worldwide, a pandemic outbreak was declared by WHO in March 2020. The infection presents with a broad clinical spectrum. Frequently, there is respiratory infection with fever (80%), dry cough (56%), fatigue (22%), and muscle pain (7%), … |
KEPLER UNIVERSITY HOSPITAL | 2023-07-31 |
| 258 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall goal of this project is to advance the understanding of underlying mechanisms impacting performance fatigability and perceived fatigability in Veterans with post-COVID-19 fatigue and explore the safety and feasibility of a home-based minimal-dose resistance exercise program in this population. The central hypothesis is that declines in force capacity, skeletal muscle oxygen extraction, and affective responses to physical activity offer potential mechanisms through which fatigability is increased in Veterans with post-COVID-19 fatigue. Moreover, home-based resistance exercise delivered remotely may provide a safe and feasibility treatment option for targeting neuromuscular and neurobehavioral factors influencing fatigability severity in this population. |
JARED M. GOLLIE; | 2023-07-31 |
| 259 | A Phase 2 Randomized, Active-controlled, Observer-blind Study to Assess The Safety, Reactogenicity, and Immunogenicity of A Booster Dose of Investigational COVID-19 MRNA Vaccines in Healthy Adults Who Previously Received A Complete Primary Vaccination Series With or Without Booster Dose(s) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the immune response and safety of a booster dose of investigational COVID-19 mRNA vaccines in healthy adults. The study will compare the investigational vaccines to control vaccine. |
GLAXOSMITHKLINE | 2023-07-28 |
| 260 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, double-blind, randomized, controlled platform trial with different interventions organized as appendices to the protocol. Each appendix (or sub-study) evaluates potential mechanisms of action, efficacy, and safety of antivirals and other therapeutics in individuals with PASC, according to the platform protocol objectives. The hypothesis is that persistent viral infection, viral reactivation, … |
KANECIA OBIE ZIMMERMAN; | 2023-07-26 |
| 261 | Comparative Study of COVID-19 Infection in Renal Transplant Recipients and Non Transplant Recipients PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-transplant patients with COVID-19 infection who attended Shenzhen No. 3 Hospital from December 2022 to February 2023, and enrolled the general population with COVID-19 infection who were hospitalized during the same period, matched by age and gender. |
YINGXIN FU.MD; | 2023-07-25 |
| 262 | Analysis of Suicide Dynamics in Link to The COVID-19 Pandemic PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Covid is a virus that first appeared in China in 2019 and was quickly described as a pandemic virus by its globalized nature. The unprecedented occurrence of the virus has led to several health and restrictive government measures. The Covid-19 pandemic and health measures have been able to contribute to the deterioration of the mental health of citizens as it has already been observed during the former pandemic context (Sars covid in 2003 in China or the Spanish flu). Among the consequences of a negative impact on mental health, … |
PHILIPPE MEYER; | 2023-07-21 |
| 263 | Incidence, Associated Factors, and Burden of Post COVID-19 Condition in Brazil PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a national retrospective cohort study with internet-based recruitment which intends to enroll 1,694 adult patients with COVID-19 diagnosis during the SARS-CoV-2 omicron wave in Brazil. Participants with confirmed symptomatic COVID-19 after january 2022 will be evaluated in order to assess incidence, potential risk factors and impact of post COVID-19 condition according to the WHO definition on health-related quality of life and other relevant patient-centered outcomes. |
INOVA MEDICAL | 2023-07-21 |
| 264 | A Randomized, Blinded, Controlled Phase II Clinical Trial to Evaluate The Immunogenicity and Safety of A COVID-19 MRNA Vaccine (ZSVG-02-O) in A Healthy Population 18 Years of Age and Older PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the immunogenicity and safety of a COVID-19 mRNA vaccine (ZSVG-02-O) in a healthy population aged 18 years and older. |
CNBG VIROGIN BIOTECH SHANGHAI | 2023-07-10 |
| 265 | BIOAEROSOL SAMPLING DEVICE (BSD) CLINICAL STUDY: Performance of Respiratory Pathogen Bioaerosol Sampling Device Compared to Matched Swab Sample With Molecular and Antigen Assays That Can Detect SARS-CoV-2 Phase II Validation PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the bioaerosol sampling device (BSD) and how it can sample patient bioaerosols (breath) and patient’s nares for the detection of COVID-19 viral particles in patients seeking to be tested for COVID-19. |
ROBERT AZURIN; | 2023-07-10 |
| 266 | An Exploratory, Randomized, Double-Blind, Dose-Ranging Study to Evaluate The Safety and Immunogenicity of TI-0010 Vaccine to Prevent COVID-19 Caused By SARS-CoV-2 in Healthy Adults Aged 18-59 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a randomized, double-blind, placebo controlled clinical exploratory study to evaluate the safety, tolerability and immunogenicity of TI-0010 vaccine in healthy adults aged 18-59. TI-0010 was manufactured by Therorna Inc. TI-0010 is a novel lipid nanoparticles (LNP) -encapsulated circRNA-based vaccine targeting RBD of SARS-CoV-2. Up to one hundred subjects will be enrolled into one of 4 cohorts. Low-dose(Dose Level 1) is for Cohort 1 and Cohort 2 , and the high dose (Dose Level 2) for Cohort 3 and Cohort 4. Cohort 1 and Cohort 3 receive 2 doses (with a 28 day interval) via intramuscular injection respectively, … |
XIAOLI LI; | 2023-07-10 |
| 267 | Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: COVID-19 can cause problems in different parts of the body. For most people, it causes fevers or trouble breathing. Some people might not recover all the way. Researchers want to see if a treatment can help with people who have recovered from COVID-19 but still have symptoms (Long COVID). Objective: To learn if human immunoglobulin (IVIG) will help with neurological symptoms of Long COVID. Eligibility: Adults ages 18 and older who had COVID-19 at least 12 weeks ago and have ongoing neurologic symptoms, such as dizziness, trouble walking, … |
AVINDRA NATH; | 2023-07-10 |
| 268 | Safety and Immunogenicity of Recombinant COVID-19 Variant Vaccine (Sf9 Cell) As A Booster Following Primary Vaccination of Either Inactivated or MRNA or Viral Vector COVID-19 Vaccines Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, phase Ⅱ, single-blind, randomized, parallel-group controlled clinical trial. The study plans to enroll subjects who have completed homologous primary vaccination with either inactivated or mRNA or Viral Vector COVID-19 vaccines (one or two doses) and have not been infected with COVID-19. All subjects will be evaluated for safety and immunogenicity after a single dose booster immunization with Recombinant COVID-19 variant Vaccine (Sf9 Cell) or inactivated COVID-19 vaccine (Vero cell) or mRNA vaccine or Viral Vector vaccine. |
WESTVAC BIOPHARMA | 2023-07-07 |
| 269 | A Controlled Clinical Trial of Group Acupuncture Therapy VS Chiropractor Group Therapy to Reduce Anxiety and Depression in People Living With HIV/AIDS (PLWH/A) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine and compare acupuncture therapy and chiropractor group therapy to reduce anxiety and depression among HIV/AIDS patients at Being Alive, Los Angeles. In this controlled clinical trial, a total of 30 patients will be divided into two groups, 15 in the acupuncture therapy group, 15 in the chiropractor group therapy. The Hospital Anxiety and Depression Scale (HADS), The Patient Health Questionnaire 9-item (PHQ-9) and Generalized Anxiety Disorder 7- item scales (GAD-7) will be used as screening tools for depressive and anxiety symptoms respectively. |
ROBERT HOFFMAN; | 2023-07-06 |
| 270 | Lymph Node Aspiration to Decipher The Immune Response of Beta-variant Recombinant Protein Booster Vaccine (VidPrevtyn Beta, Sanofi) Compared to A Bivalent MRNA Vaccine (Comirnaty Original/Omicron BA.4-5, BioNTech-Pfizer) in Adults Previously Vaccinated With at Least 3 Doses of COVID-19 MRNA Vaccine. Ancillary of COVIBOOST 2 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In order to investigate whether a germinal center response occurs following vaccine boost and to characterize it based on the type of vaccine received, we aim to analyze Spike and/or RBD-specific germinal center B cells within the draining lymph nodes. To achieve this, we will perform lymph node fine needle aspiration of the draining lymph node in 6 subjects in each study arm, 3 to 6 weeks after the booster vaccine injection. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-07-05 |
| 271 | SARS-CoV-2 Re-Infection Risk and Vaccine Efficacy in Austria: SARIVA Study PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The coronavirus disease 2019 (COVID-19) pandemic was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In this study, we aim to evaluate how strong and how long are individuals in Austria after vaccination and/or infection with SARS-CoV-2 protected against COVID-19 disease. In this project, … |
MEDICAL UNIVERSITY OF GRAZ | 2023-07-01 |
| 272 | CO-CREATE-Ex: Community-engaged Optimization of COVID-19 Rapid Evaluation And TEsting Experiences PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Throughout the Coronavirus disease (COVID-19) pandemic, rates of COVID-19 have been persistently high in San Diego County’s central and southern communities near the United States/Mexico border. These regions predominantly house Latino residents, the ethnic minority community most impacted by COVID-19 in San Diego. In the Phase I project, University of California, San Diego (UCSD) partnered with San Ysidro Health (SYH) and the Global Action Research Center, to co-create and demonstrate the impact of a COVID-19 testing program in San Ysidro, one of the most impacted areas from COVID-19 in San Diego County. To date, … |
LOUISE LAURENT; | 2023-07-01 |
| 273 | Tick-borne Encephalitis Virus Research in Limousin PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Cases of encephalitis of varying severity have been described in recent years in eastern France involving tick-borne encephalitis virus (TBEV). The main objective is to demonstrate the presence of TBEV in Limousin, in patients with a positive Lyme serology, or a neurological picture compatible with TBEV. |
SEBASTIEN HANTZ; | 2023-07-01 |
| 274 | Immunogenicity & Safety of IndoVac® As A Homologous Booster Dose Against COVID-19 in Adults Aged 18 Years and Above in Indonesia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Open-label, prospective intervention study of IndoVac® as a single, homologous booster dose |
YETTY MOVIETA NENCY; | 2023-07-01 |
| 275 | Comparison of The Two-year Efficacy of Three Exercise Rehabilitation Strategies on Dyspnea in Patients Who Presented With Secondary Respiratory Distress Syndrome Secondary to Severe COVID-19 Pneumonia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Dyspnea is defined by a subjective sensation of respiratory discomfort, the intensity of which varies according to the terrain, the anamnesis and the cause. Resuscitation is associated with many causes of dyspnea, including initial distress, mechanical ventilation, or after-effects following the pathology and its management. Respiratory distress is the most severe form of impaired lung function. It is the first cause of hospitalization in intensive care. This distress, indicative of the failure of the respiratory system, … |
GROUPE HOSPITALIER PARIS SAINT JOSEPH | 2023-07-01 |
| 276 | A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study team proposes to evaluate the efficacy of Astepro® 0.15% nasal spray in treating SARS-CoV-2 infection in adults through a pilot and feasibility clinical trial at the University of Chicago. |
BRANDON BAIRD; | 2023-07-01 |
| 277 | Home_Based Digital Mindful Dance Program for Breast Cancer Cases: Feasibility, Body-Mind Awareness and Quality of Life PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: During COVID-19, telecare replaces face-to-face contact to maintain social distance and reduce the spread of the virus. The current epidemic is coming to the end. However, for breast cancer cases, no matter in the treatment or survival stage, they face physical and mental symptoms, such as social isolation, which affects their quality of life. Studies have shown that mindfulness and dance can help breast cancer cases improve depression and quality of life, but most of them are conducted face-to-face. Online mindful/dance helped breast cancer cases without the limitations of the time, space, distance, and treatment status, … |
I-CHING HOU; | 2023-07-01 |
| 278 | Saliva Testing for SARS-CoV-2 With Lollipop Swab PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will explore whether lollipop swabs are more acceptable and perform as well as nasal swabs with PCR testing. The study will be open to enrollment for both children and adults in the Madison community who have at least one COVID-19 symptom that has presented in the last 5 days and who have not had a positive COVID-19 test for a previous illness within the past 3 months. Participants can expect to be in the study for the duration of the swabbing, approximately 10 minutes. |
ELLEN WALD; | 2023-07-01 |
| 279 | Impact of A History of Tonsillectomy or Adenoidectomy on The Severity of COVID-19 : AMYVID Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Little is known about the impact of tonsillectomy and/or adenoidectomy on the severity and presentation of respiratory infections, let alone COVID-19. Current knowledge of the role of NALT suggests that its absence may be associated with an increased risk of severe disease. Assessing the impact of tonsillectomy and adenoidectomy on the risk of adverse evolution in COVID-19 would help to better identify patients at risk of adverse evolution, … |
UNIVERSITY HOSPITAL ANGERS | 2023-07-01 |
| 280 | Prevalence of Asymptomatic COVID-19 Infection in Pediatric Surgical Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Children infected with COVID-19 are mostly asymptomatic. There is a dearth of data on the epidemiology of COVID-19 in the pediatric population. This is a prospective observational clinical study of pediatric surgical patients. COVID-19 rapid antigen testing will be performed on pediatric patients. |
OLUMUYIWA BAMGBADE; | 2023-07-01 |
| 281 | Risk of Contamination By COVID-19 During Oral Care With Aerosolization PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The sudden Covid-19 pandemic has led all healthcare workers to adapt to an unprecedented situation by continuing to provide care while protecting themselves and their patients. Medical care with aerosolization systems is particularly of risk because of the strong propagation of the droplets they generate, especially during oral care. Considering the high risk of transmission of the SARS-CoV-2 virus in dental structures remain essential and still very challenging. The need to put in place care procedures to protect the nursing staff and patients is definitely more than necessary. Dental protection equipments against this emergent virus have progressively integrated daily practice, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-07-01 |
| 282 | Study on Post-Acute COVID-19 Syndrome in Improvement of COVID-19 Rehabilitated Patients By Respiratory Training PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Since the emergence of Corona Virus Disease 2019(COVID-19), it has spread rapidly around the world, And it has had a profound impact on the lives and health of people around the world, most of the COVID-19 positive patients are 3-4 weeks after the onset of infection patients can turn negative and recover, however, increasing observational data suggest that these patients long-term or recurring symptoms such as: fatigue, palpitations, cognitive impairment, dyspnea, anxiety, chest tightness and Pain, etc., symptoms may last at least two months or even longer (for example, up to 12 months), … |
YAO-HSIANG CHEN; | 2023-07-01 |
| 283 | Acceptance and Effectiveness of SARS-COV-2 Vaccination in Systemic Sclerosis Patients Treated By Autologous Hematopoietic Stem Cell Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: On December 27th 2020, the implementation of SARS-CoV-2 vaccination in France first became available amongst all immunosuppressed patients at very high risk of severe Coronavirus Disease (COVID-19) infection, specifically for Hematopoietic Stem Cell Transplant recipients or other fragile immunosuppressed patients. Systemic sclerosis (SSc) is an autoimmune disease characterized by dysregulation of the immune system, vascular damage and progressive fibrosis of the skin and internal organs (heart, lung and kidney) which may lead to severe comorbidities and SSc-related mortality. In severe rapidly progressive SSc, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-07-01 |
| 284 | Cortical Excitability and Neuropsychological Behavior Changes Following COVID-19 Infection in The Human Brain PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The global COVID-19 pandemic has now led to millions of infections worldwide. It produces long-lasting changes in the general physiology of multiple organs, including the brain. Thus, this study aimed to comprehensively understand the cortical excitability and neuropsychological behavior changes in patients following SARS-CoV-2. |
RENJI HOSPITAL | 2023-07-01 |
| 285 | A Multicenter, Randomized, Double-Blind, Controlled, Phase Ⅲ Clinical Trial of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell) in Booster Vaccination to Evaluate Efficacy, Safety and Immunogenicity in Population Aged 18 Years Old and Above PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase Ⅲ Clinical Trial of Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine (Sf9 Cell) in Booster Vaccination to Evaluate Efficacy, Safety and Immunogenicity |
WESTVAC BIOPHARMA | 2023-06-30 |
| 286 | A Clinical Trial to Evaluate The Safety and Immunogenicity of Recombinant COVID-19 Bivalent (XBB+Prototype) Protein Vaccine (Sf9 Cell) (WSK-V101C) in Booster Vaccination in Healthy Population 18 Years Old of Age and Above PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A Clinical Trial of Recombinant COVID-19 Bivalent (XBB+Prototype) Protein Vaccine (Sf9 Cell) in Booster Vaccination to evaluate safety and immunogenicity in healthy population aged 18 years old and above. |
WESTVAC BIOPHARMA | 2023-06-30 |
| 287 | Women’s Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH) Equity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Inequalities in COVID-19 infection, hospitalization, and death in under-studied, under-represented, and under-reported groups of people are severe. A growing number of studies have assessed the impact of individual risk factors. But few studies have assessed which factors are the greatest drivers of COVID-19 disparities from a wider perspective. Objective: To understand the long-term impacts of COVID-19 on minority women and their families to assist in developing community-based programs to help in recovery. Eligibility: Healthy people aged 18 and older who reside in North Carolina. Design: Participants will take a 45-minute online survey. The survey will cover their demographics, community, … |
JOAN P PACKENHAM; | 2023-06-30 |
| 288 | Open Phase I/IIa Clinical Trial to Evaluate The Safety and Efficacy of Allogenic Administration of Treg Cells Obtained from Thymic Tissue (thyTreg) to Control The Immune Hyperactivation Associated with COVID-19 And/or Acute Respiratory Distress Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators developed a GMP protocol to isolate Treg cells from thymic tissue (thyTreg). The thyTreg cells are being evaluated in a Phase I/II clinical trial to evaluate the safety and efficacy of the adoptive transfer of autologous thyTreg to prevent rejection in heart transplant children (NCT04924491), with preliminary results indicating the feasibility and safety of the therapy. In addition, thyTreg cells have shown low immunogenicity in the pre-clinical setting, indicating that allogeneic use of these thyTreg cells (allo-thyTreg) would have a low risk of adverse effects. These thyTreg cells could inhibit an excessive inflammation in SARS-CoV-2 infection, … |
RAFAEL CORREA-ROCHA; | 2023-06-27 |
| 289 | Have Physical Therapists Attitudes and Beliefs Towards Vital Assessment Changed Following The COVID-19 Pandemic? PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Previous studies prior to the COVID-19 pandemic show that cardiovascular and blood pressure assessment by physical therapists is inadequate or lacking despite prior training. Since the COVID-19 pandemic, assessment of cardiovascular and respiratory function may become more critical as the manifestation of long COVID has become a concern. The purpose of this study is to determine whether physical therapists’ attitudes and beliefs towards vital sign assessment have changed following the COVID-19 pandemic. |
EDMUND C ICKERT; | 2023-06-26 |
| 290 | Impact Of Sensory Re-Education Paradigm On Sensation And Quality Of Life In Patients Post-Covid 19 Polyneuropathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to investigate the effect of a sensory re-education paradigm on sensation and proprioception in patients with post covid-19 neuropathy. |
YOUNES ALI KHADOUR; | 2023-06-26 |
| 291 | Prevalence and Risk Factors of Anxiety and Depression in Two Populations of Policemen During The Health Crisis Linked to COVID-19 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To date, there is little international data on depression and anxiety among police officers apart from studies carried out after an attack or natural disaster. At the national level, no mental health data exists for police officers, apart from those from the Paris attacks, and the work of investigators after the Strasbourg attack (article in press). During the covid crisis, in Alsace, the police, like the rest of the population, took the full brunt of the pandemic. The police, however, are part of essential professions and have not been confined, but on the contrary, … |
UNIVERSITY HOSPITAL STRASBOURG FRANCE | 2023-06-20 |
| 292 | A Phase 2/3, Randomized, Double-blinded , Parallel Controlled Trial to Evaluate The Immunogenicity, Safety and Efficacy of A Heterologous Booster Dose With COVID-19 MRNA Vaccines (Bivalent) , in Previously Vaccinated Subjects Against COVID-19 With 2/3 Doses COVID-19 Vaccine Compared to A Booster Dose With MRNA COVID-19 Vaccine（Pfizer Bivalent Vaccine）in Adults PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Immunogenicity Objective：Cohort 1: GMTs of SARS-CoV-2 Omicron and related strain neutralizing antibody levels for SWIM816.Cohort 2: To demonstrate the non- inferiority of neutralizing antibody response in terms of geometric mean titers (GMT) of COVID-19 mRNA vaccine(SWIM816) compare with mRNA COVID-19 vaccine(Pfizer Bivalent vaccine) 14 days post dose. Primary Safety Objective：To assess the reactogenicity and safety of a booster dose in a heterologous vaccination regimen in subjects previously immunized with 2/3 doses of COVID-19 vaccine with or without previously diagnosed with COVID-19. Secondary Immunogenicity Objectives：To describe the neutralizing antibody response at D29, … |
MAYFONG MAYXAY; | 2023-06-20 |
| 293 | LIAISON NES Flu A/B & COVID-19 Clinical Agreement in Australia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The DiaSorin Molecular LIAISON® NES FLU A/B & COVID-19 real-time RT-PCR assay is intended for use on the DiaSorin LIAISON® NES instrument for the in-vitro qualitative detection and differentiation of nucleic acid from influenza A, influenza B and SARS-CoV-2 virus from dry nasal swabs (NS) from human patients with signs and symptoms during the acute phase of respiratory tract infection in conjunction with clinical and epidemiological risk factors. The LIAISON® NES FLU A/B & COVID-19 assay is intended for use as an aid in the differential diagnosis of influenza A, … |
JANET FARHANG; | 2023-06-19 |
| 294 | An Open Label, Phase III Clinical Trial (Immunobridging Study) of INAVAC (Vaksin Merah Putih – UA-SARS CoV-2 (Vero Cell Inactivated)) in Healthy Population Aged 12 to 17 Years Old PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label, phase III trial – immunobridging study. There will be only 1 group in the study. All subjects (12 to 17 years old) will receive INAVAC 5 µg dose. The vaccine will be administered with 2-dose schedule, intramuscularly, with 28 day interval. All subjects will be followed for 12 months. INAVAC is an inactivated vaccine made of SARS-CoV-2 virus isolated from a patient in Surabaya, composed with aluminium hydroxy gel, tween 80, and L-histidine, and this study will be the first phase III in adolescents. |
DOMINICUS HUSADA; | 2023-06-19 |
| 295 | Autonomous Covid-19, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and Influenza Treatment System With Machine Learning in Outpatient Settings PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-tabled, one-arm observatory trial to assess the effectiveness and safety of the Autonomous Treatment System Based on Machine Learning in patients with Covid-19, Post-Acute Sequelae of SARS-CoV-2 infection and influenza. |
LIZORA | 2023-06-16 |
| 296 | Project IMPROVE: Implementing Community-Engaged Intervention Research to Increase Rapid SARS-CoV-2 Self-Testing Among Diverse Underserved and Vulnerable Asian Americans PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to engage community partners to implement IMPROVE intervention and promote (COVID-19) rapid testing among vulnerable Asian Americans in the Greater Philadelphia Area and New York City |
TEMPLE UNIVERSITY | 2023-06-15 |
| 297 | A Phase I Clinical Trial to Evaluate The Safety, Tolerance and Pharmacokinetics of A Broad-Spectrum Neutralizing Antibodies SA55 Injection of COVID-19 in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this first-in-humans dose escalation study, SA55 will be evaluated for safety, tolerability, and pharmacokinetics. The study is intended to enable future studies of SA55-injection’s efficacy in preventing and treating COVID-19. |
RONGHUA JIN; | 2023-06-15 |
| 298 | Effect of Pulmonary Tele-rehabilitation With and Without Progressive Muscle Relaxation Program in Covid-19 Patients After Hospital Discharge: Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate efficacy of internet based pulmonary rehabilitation and progressive muscle relaxation program on functional capacity, depression and anxiety, dyspnea, fatigue, sleep quality and quality of life in covid19 patients after hospital discharge |
IRAN UNIVERSITY OF MEDICAL SCIENCES | 2023-06-15 |
| 299 | An Open-label and Single-center Phase IIa Trial to Evaluate The Immunogenicity and Safety of SARS-CoV-2 DNA Vaccine (ICCOV) in Healthy Subjects Aged 18-75 Years PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-labeled, no placebo, Phase IIa clinical trial. The purpose of this study is to evaluate the immunogenicity and safety of one booster vaccine dose of SARS-CoV-2 DNA Vaccine (ICCOV) in adults aged 18 to 75 years who have received two to four dosese of COVID-19 vaccine. |
IMMUNO CURE 3 | 2023-06-15 |
| 300 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Trial Evaluating The Efficacy and Safety of WPV01 in Patients With Mild to Moderate COVID-19 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a multicenter, randomized, double-blind, placebo-controlled efficacy, safety Phase III clinical trial designed to evaluate the efficacy and safety of WPV01 in patients with mild/moderate COVID-19. |
WESTLAKE PHARMACEUTICALS HANGZHOU | 2023-06-14 |
| 301 | The Investigation of Emotional Changes Between Emergency and Intensive Care Unit and On-site Counter Staffs After COVID-19 Infection and Exploring The Impact of Personnel Emotional Adjustment About Duty and Future Planning PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The emotional and work changes of the staffs and the on-site counter staffs will have a certain impact during this pandemic period. Because a large number of critically ill patients are obstructive in emergency and critical care uint. It will induce a huge impact on the deployment of medical team manpower The purpose of this study is to understand the situation of emergency and intensive care unit personnel after covid-19 infection. It will help the hospital superintendent to understand the impact of emotional adjustment on its own work, understand the emotional situation of on-site personnel, future planning and r deployment. |
CHIA-HSI CHEN; | 2023-06-14 |
| 302 | A PHASE 1, RANDOMIZED, FIXED SEQUENCE, MULTIPLE-DOSE, OPEN-LABEL STUDY TO ESTIMATE THE EFFECT OF NIRMATRELVIR (PF-07321332)/RITONAVIR ON ROSUVASTATIN PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn about the effect of the study medicine (called nirmatrelvir/ritonavir) on the pharmacokinetics of the medicine rosuvastatin in healthy volunteers. Pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it. This study is seeking participants who: – are male and female participants who are overtly healthy – are 18 years of age or older – have a Body mass Index (BMI) of 16-32 kg/m2 and total body weight >50 kg (110 lb). All participants in this study will receive nirmatrelvir/ritonavir, … |
PFIZER | 2023-06-14 |
| 303 | A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy and Safety of S-217622 in The Prevention of Symptomatic SARS-CoV-2 Infection in Household Contacts of An Individual With Symptomatic COVID-19 PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to measure the proportion of participants who are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (positive reverse transcription polymerase chain reaction \[RT-PCR\] test) and have coronavirus disease 2019 (COVID-19) symptom(s) with S-217622 tablets compared with placebo tablets in participants who are household contacts of an individual with symptomatic COVID-19. |
SHIONOGI | 2023-06-09 |
| 304 | Open-label, Multi-centre, Non-Inferiority Study of Safety and Immunogenicity of BIMERVAX As Heterologous Booster for The Prevention of Coronavirus Disease 2019 (COVID-19) in Adolescents From 12 Years to Less Than 18 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase IIb, open-label, uncontrolled, multi-centre, non-inferiority clinical trial, to assess the safety and immunogenicity of BIMERVAX® as a heterologous booster dose in adolescents. In this study a total of 300 adolescents from 12 to less than 18 years will be enrolled and followed for 12 months. |
HIPRA SCIENTIFIC S L U | 2023-06-08 |
| 305 | A Study of The Trajectory of Overall Systemic Health Outcomes and Potential Complications in Recovered COVID-19 Patients PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Clarify the incidence of functional impairments in cured COVID-19 patients and identify influencing factors. Build a multi-omics database for COVID-19 patients in the recovery period to elucidate the biological biomarkers and targets associated with functional impairments. Comprehensive exploration of the long-term prognosis, complications, sequelae, and risk factors of COVID-19 patients after Omicron infection, as well as their immune characteristics. Compare the impact of different strains of the COVID-19 virus on prognosis and immune response. Develop comprehensive rehabilitation intervention strategies for COVID-19 patients with functional impairments and evaluate the impact of different intervention methods on their prognosis. Based on clinical data, … |
ZHAOHUI TONG; | 2023-06-07 |
| 306 | Study of of Oxygen Nebulized Inhalation EGCG in Cancer Patients With New Coronary：Phase II Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions, such as anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects via modulation of a variety of intracellular signaling cascades. In addition, preclinical studies have also emphasized the antiviral activity of epigallocatechin-3-gallate (EGCG), including SARS-CoV-2. In previous studies, we found that EGCG can prevent and cure radiation- induced normal tissue damage in tumor patients. In clinical studies, we found that EGCG can prevent and treat radiation-induced acute radiation esophagitis, acute radiation skin injury, acute radiation oral mucositis with high safety. At the same time, … |
HAN XI ZHAO; | 2023-06-05 |
| 307 | A STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF COMBINED VACCINE CANDIDATE(S) AGAINST INFECTIOUS RESPIRATORY ILLNESSES, INCLUDING COVID-19 AND RSV, IN HEALTHY INDIVIDUALS PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to learn about the safety and effects of a combined vaccine for RSV and COVID-19 when given with a seasonal flu vaccine or when given alone. A combined vaccine will help to reduce the number of vaccinations given when trying to prevent respiratory infections. This study is seeking participants who: – are 65 years of age or older. – are healthy or have well-controlled chronic conditions. – in the past have received at least 3 US-authorized mRNA COVID 19 vaccines, … |
PFIZER | 2023-06-01 |
| 308 | Incidence of Severe COVID-19 Infection in Patients With Chronic Lymphocytic Leukemia or Indolent B-cell Non-Hodgkin Lymphoma Who Received Pre-exposure Prophylaxis With Tixagevimab and Cilgavimab in Italy: An Observational Study By The GIMEMA Working Party on Chronic Lymphoproliferative Disorders and By The Fondazione Italiana Linfomi PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational retrospective and prospective multicenter study aimed at describing the role of the COVID -19 prophylaxis with Tixagevimab and Cilgavimab in CLL or indolent B-NHL patients who received first COVID-19 prophylaxis dose between March 2022 and October 2022. |
GRUPPO ITALIANO MALATTIE EMATOLOGICHE DELL’ADULTO | 2023-06-01 |
| 309 | Evaluating The Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Frontline Health Care Workers (The HCW-CBTi Study): A 2-arm, Pragmatic, Prospective, Parallel Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The COVID-19 pandemic has resulted in increased workload and concerns about personal and family safety for frontline healthcare workers (HCWs), which can lead to decreased well-being and worsening mental health. Sleep disruption is particularly prevalent among HCWs providing frontline COVID-19 care. It can have direct consequences on their cognitive and emotional functioning, as well as on patient safety. Cognitive Behavioral Therapy for insomnia (CBTi) is a first-line treatment for insomnia. It has been shown to improve sleep health and wellbeing in the general population. However, there are significant barriers to delivering CBTi to frontline HCWs, … |
MANDEEP SINGH; | 2023-06-01 |
| 310 | Recurrent Salivary Gland Infections in Covid-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to find out the role of Covid-19 in salivary gland infection and its recurrence. |
ESLAM FARID ABU SHADY; | 2023-06-01 |
| 311 | Impact of Mental Health and Cognitive Disorders on Quality of Life in Severe Covid-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this single-center retrospective observational study is to describe cognitive and psychological outcomes and their impact on quality of life after at least 3 months of intensive care unit (ICU) discharge in severe COVID-19 survivors. |
JOSÉ RAIMUNDO ARAUJO DE AZEVEDO; | 2023-06-01 |
| 312 | Low-Carbohydrate Dietary and Lifestyle Interventions for The Management of Long COVID-19 Syndrome: A Prospective and Interventional Randomized Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Hyper-inflammatory responses seen in acute COVID-19 are also a feature of long covid, a condition of long-term consequences that are persisting or appearing after initial infection and recovery from acute COVID-19. Long-standing, often disabling symptoms are common in long covid and can be highly varied. Common symptoms include fatigue, brain fog, muscle and chest pain, migraines, shortness of breath, anosmia, muscle weakness, and cognitive dysfunction. 35% of post-COVID patients were found to have decreased kidney function at 6 months post-discharge. In this study, … |
NURIA M. PASTOR-SOLER; | 2023-06-01 |
| 313 | Beta-glucans As Immune Modulators Amongst Hospitalised Patients With COVID-19: A Pilot Randomised Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomised trial aims to assess the role of beta1-3 glucan supplementation in improving clinical symptoms and other outcomes amongst hospitalised patients with COVID-19. |
MARIA JOSÉ RUZ; | 2023-06-01 |
| 314 | A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study to Evaluate The Safety and Efficacy of Sesderma LACTYFERRIN™ Forte and Sesderma ZINC Defense™ (Liposomal Bovine Lactoferrin (LbLf) and Liposomal Zn (LZn)) and Standard of Care (SOC) Vs SOC in The Treatment of Non-hospitalized Patients With COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the safety and efficacy of Sesderma LACTYFERRIN™ Forte and Sesderma ZINC Defense™ in non-hospitalized patients with COVID-19. The main question is: Is there a reduction in the signs and symptoms of COVID-19 from baseline to end of treatment? Participants will complete the following activities. – Screening and first day of treatment – Treatment that will be administered for up to 10 days, two treatment evaluation visits will be completed – After treatment completion. Two visits are scheduled, … |
JOSE DAVID SUAREZ; | 2023-06-01 |
| 315 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine The Effects of Oxaloacetate on Improving Fatigue in Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Following acute COVID-19, some patients develop a group of debilitating symptoms that include fatigue, orthostatic intolerance, difficulty with attention and concentration (often called brain fog), myalgias and disrupted sleep. The term Long COVID is used to describe these symptoms after the initial viral infection has passed. These symptoms are the same as those that define myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A Proof of Concept trial showed significant fatigue benefit in Long COVID patients. This randomized, … |
LUCINDA BATEMAN; | 2023-06-01 |
| 316 | The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to assess if glutathione, along with NAC (N-acetyl cysteine) and Alpha lipoic acid (ALA), can help reverse some of the COVID long-haul symptoms.Subjects will be randomized in to one of two groups. Depending on the group they are randomized in to, subjects will be taking either a combination of NAC, Alamax CR, and liposomal GSH or the same three nutritional supplements with a multivitamin and magnesium. Regardless of the group, subjects will be asked questions to assess their COVID symptoms, … |
ALPESH N AMIN; | 2023-06-01 |
| 317 | A Phase 2 Study to Evaluate The Safety, Tolerability, Reactogenicity, and Immunogenicity of Baiya SARS-CoV-2 Vax 2 Vaccine As A Booster Following Vaccination for COVID-19 in Adults Between 18 and 64 Years PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigational product Baiya SARS-CoV-2 Vax 2 vaccine is a second-generation of protein subunit vaccine from plant to prevent COVID-19 disease. This is a Phase 2, randomised, and double-blinded study to assess the safety, tolerability, reactogenicity and immunogenicity of Baiya SARS-CoV-2 Vax 2 vaccine, when used as a booster vaccination following vaccination with the alternate and widely used COVID-19 vaccines, which are AstraZeneca vaccine or mRNA vaccine. |
BAIYA PHYTOPHARM | 2023-06-01 |
| 318 | A Comparative Analysis of Coronary Microvascular Dysfunction in Stable Angina Patients With and Without Severe COVID-19 History PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The COMET trial is an observational, cross-sectional study aimed at comparing the incidence of coronary microvascular dysfunction (CMD) in patients with stable angina who have a history of severe COVID-19 infection requiring mechanical ventilation (Group A) to those without a history of COVID-19 (Group B). A total of 56 participants will be recruited, with 28 patients in each group. Data will be collected on participants’ demographic information, medical history, and COVID-19 infection history (confirmed by PCR test). CMD measurement will be performed using a pressure-temperature wire to assess the coronary flow reserve and index of microcirculatory resistance. In addition, … |
ALI ALDUJELI; | 2023-06-01 |
| 319 | Efficacy of Bailing Capsule on Pulmonary Fibrosis After COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Pulmonary fibrosis is a sequela of severe infection COVID-19.The prevalence of PCFP ranged from 2% to 45%,and the pathogenesis of PCFP has not been clearly elucidated.The ingredient of Bailing capsule is Cs-C-Q80,it has obvious protective effect on lung. Studies have shown that Bailing capsule may improve the clinical symptoms of PCPF patients through anti-fibrosis, oxidation and anti-inflammatory effects in multiple pathways. The purpose of this study was to evaluate the efficacy and safety of bailing capsule in treating PCFP after COVID-19 infection. |
HAIBIN DAI; | 2023-05-31 |
| 320 | A Randomized, Open-Label, Parallel-controlled Clinical Study on Booster Immunization of Two COVID-19 Vaccines Constructed From Different Technical Routes Among People Aged 18 Years and Older PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label, randomized, parallel-controlled clinical trial conducted in people aged 18 years and older to evaluate the immunogenicity and safety of two SARS-CoV-2 bivalent vaccines constructed by adenovirus type 5-based or mRNA-based technics. |
JIANYING HUANG; | 2023-05-30 |
| 321 | Effects of Sulfurous Thermal Waters Inhalations on Long-COVID Syndrome: A Double-blinded, Interventional, Randomized Case-control, Pilot Study on A Spa Centered Rehab Program PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this double-blind, interventional, randomized case-control, pilot trial is to evaluate the effects of active sulfurous (STW) versus placebo (SDW) inhalations on blood test parameters, serum inflammatory cytokines, spirometry data, as well as qualitative and quantitative changes in the nasal microbiome of subjects affected by long Covid. The main questions it aims to answer are: – if STW inhalations are effective on respiratory issues due to long covid compared to the placebo inhalation (SDW) – if STW inhalations are effective on long covid related fatigue issues compared to the placebo inhalation (SDW) – … |
MARIO FONTANA; | 2023-05-30 |
| 322 | Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in A Tertiary Care Hospital in Bangladesh: A Quasi-Experimental Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This quasi-experimental study aims to evaluate the efficacy and safety of pulmonary rehabilitation in post-COVID-19 patients and compare differences in primary outcomes before and after pulmonary rehabilitation. Its main aim is to provide an answer to the following question: What are the outcomes of pulmonary rehabilitation in post-COVID-19 patients in a tertiary care facility in Bangladesh? The participants will participate in 06 weeks of comprehensive multimodal and multidisciplinary outpatient pulmonary rehabilitation, including endurance training, strength training, patient education, relaxation techniques, psychological support, and nutritional counseling. |
MOHAMMED ATIQUR RAHMAN; | 2023-05-25 |
| 323 | Retrospective Cohort Study of The Physiotherapy Procedure in Critically Ill Patients Diagnosed With COVID-19 During The First Wave PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Retrospective cohort study that will include patients from the ICU of the Hospital de la Santa Creu i Sant Pau in Barcelona during the period between March 11 and May 13, 2020. The cohorts are made up of two groups of patients admitted for severe COVID during the first wave, according to whether or not they received physiotherapy and the possible impact of physiotherapy on the days of mechanical ventilation in the two study groups will be studied. |
FUNDACIÓ INSTITUT DE RECERCA DE L’HOSPITAL DE LA SANTA CREU I SANT PAU | 2023-05-23 |
| 324 | Effectiveness of A Second COVID-19 Vaccine Booster in Chinese Adults Aged 18 Years or Above: A Multicenter, Parallel Groups, Partially Randomized, Open-label, Blank-controlled Adaptive Platform Trial PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, parallel groups, partially randomized, open-label, blank-controlled adaptive platform study to evaluate the effectiveness of a second COVID-19 vaccine booster in Chinese adults who are charactered as the majority of whom with hybrid immunity of COVID-19 vaccination and COVID-19 breakthrough infection. Individuals aged 18 years and over, include the elderly over 60 years old or those with underlying diseases (history of underlying medical conditions diagnosed by a clinician, including hypertension, diabetes, heart disease, … |
JING-XIN LI; | 2023-05-18 |
| 325 | The Role of Chlorhexidine in Minimizing The Viral Load Among COVID-19 Patients: A Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Existing evidence confirmed that saliva and oral cavity to be a reservoir for SARS-CoV-2. In dental clinic aerosol-producing-procedures pose a significant risk for transmission of the infection . It is very important to minimize the risk of transmission in dental office reducing the load of SARS-CoV-2 in saliva if possible, in suspect or conformed cases. Preprocedural mouth rises have been used widely to minimize the number of oral microorganisms. Multiple studies confirmed the efficacy of those mouth rinses in reducing the possibility of transmission of SARS-CoV-2 infection . |
ZUHAIR SALEH NATTO; | 2023-05-18 |
| 326 | Use of A Hypochlorous Acid Spray Solution in The Treatment of COVID-19 Patients : COVICONTROL Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective is To evaluate the efficacy and safety of nasal spray and mouth spray application with hypochlorous acid-containing solution versus placebo as a curative treatment for hospitalized SARS-CoV-2 positive patients And for symptomatic SARS-CoV-2 positive patients followed as outpatients |
SEMIR NOUIRA; | 2023-05-15 |
| 327 | Amygdala Insula Retraining in The Management of Long COVID Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to compare a mind body intervention against usual care in patients with fatigue with long COVID. Our research questions include 1. Is the mind body intervention additive to usual care in long COVID 2. Can the mind body intervention change laboratory markers, heart rate variability and dysautonomia. |
LEONARDO TAMARIZ; | 2023-05-15 |
| 328 | A Prevalence Study of Persistent COVID-19 in Punta Arenas, Magallanes and Chilean Antarctic Region PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This cross-sectional observational study aims to determine the prevalence of Persistent COVID-19 in 282 individuals in Punta Arenas, Magallanes and Chilean Antarctic Region. Persistent COVID-19 is a complex array of symptoms that persist or emerge for more than 4 weeks beyond SARS-CoV-2 infection. Recent studies suggest that up to 80% of survivors may develop chronic multi-organ dysfunction due to persistent inflammation and immune dysregulation, making it an ongoing public health concern worldwide. The study aims to (1) describe and establish the frequency of physical and psychological signs and symptoms in adult patients who have tested positive for COVID-19, … |
MARCELO A. NAVARRETE SIGNORILE; | 2023-05-15 |
| 329 | Study on The Remote Diagnosis and Treatment Strategy of New-onset Insomnia Under The COVID-19 Epidemic PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Insomnia is a disorder characterized by both nocturnal and daytime symptoms. The main symptoms are unsatisfactory sleep quality or duration, accompanied by difficulty falling asleep before bedtime, frequent or prolonged awakenings, or an inability to fall back asleep after waking in the early morning. Our previous investigation has confirmed that during the period of home isolation of the epidemic, the community people suffered from acute insomnia induced by the epidemic. In order to comprehensively, efficiently and scientifically respond to major public health emergencies such as the COVID-19 epidemic and its long-term impact, … |
NANFANG HOSPITAL SOUTHERN MEDICAL UNIVERSITY | 2023-05-15 |
| 330 | An Open Label, Control Study to Evaluate The Efficacy and Safety of Ropeginterferon Alfa-2b in Adult COVID-19 Patients With Comorbidities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy of subcutaneous ropeginterferon alfa 2b ( P1101 combined with standard of care (SOC) compared with standard care alone in adult COVID-19 patients with comorbidities. |
WANG-HUEI SHENG; | 2023-05-15 |
| 331 | Exhaled Breath Aerosol for The Etiological Diagnosis of Respiratory Tract Infections: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pilot study for the evaluation of the feasibility of pathogen detection in exhaled breath aerosols (XBAs) samples using the AveloCollect device. The aim of the study is to evaluate the feasibility of XBA collection and molecular detection of respiratory pathogens using the AveloCollect BlowTube device (index test) in subjects with a clinical presentation consistent with a respiratory infectious disease, compared to the same molecular assays performed on nasopharyngeal secretions (using commercially available swabs) and sputum (comparator tests). |
DANIELA MARIA CIRILLO; | 2023-05-15 |
| 332 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate The Efficacy and Safety of SHEN26 Capsule in Adult Participants With Mild to Moderate COVID-19 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-parallel-controlled phase III clinical trial. It is designed to evaluate the efficacy and safety of SHEN26 capsules in Chinese adult patients with mild to moderate COVID-19 |
SHENZHEN KEXING PHARMACEUTICAL | 2023-05-13 |
| 333 | Quantitative Computed Tomography to Assess Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations |
MAHER GHAMLOUSH; | 2023-05-12 |
| 334 | Evaluation of Tuberculosis Treatment Outcomes Before, During and After COVID-19 in A Dedicated Outpatient Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Tuberculosis (TB) is an infectious disease caused by Mycobacterium species grouped in the Mycobacterium tuberculosis complex. TB remains a major global health problem, despite the fact that there are drugs that can eradicate the infection. The study aims to describe the clinical, microbiological, therapeutic and prognostic characteristics of TB patients afferent to the SC Infectious Diseases of A.O. SS Antonio e Biagio e Cesare Arrigo of Alexandria during 2019-2022 and, secondarily, … |
AZIENDA OSPEDALIERA SS ANTONIO E BIAGIO E CESARE ARRIGO DI ALESSANDRIA | 2023-05-08 |
| 335 | An Interventional, Randomized, Parallel Controlled, Investigator Initiated Study to Investigate The Safety, Immunogenicity of Bivalent RQ3027 and RQ3025 MRNA Vaccine As A Booster Dose in 3 Doses COVID-19 Vaccine-Experienced Healthy Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aimed to gather safety and immunogenicity data in COVID-19 vaccine-experienced healthy adults. The main questions it aims to answer are: – The neutralizing antibodies levels of bivalent mRNA vaccines RQ3027(Alpha/Beta+Omicron XBB.1.5) and RQ3025(Alpha/Beta+Omicron BA.2/4/5) and monovalent mRNA vaccine RQ3013 against the current SARS-CoV-2 circulating variant. – The safety profile of RQ3027 and RQ3025 given as a second booster dose to COVID-19 vaccine-experienced participants 18 through 55 years of age. – Explore the protective efficacy by documenting confirmed COVID-19 cases after vaccination. |
JIA WEI; | 2023-05-08 |
| 336 | A Single-blinded Sham-controlled Crossover Trial to Evaluate The Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the efficiency and safety of immunoadsorption for the treatment of post-COVID syndrome (PCS). Efficacy will be measured (1) subjectively as an improvement of the score of questionnaires like the multidimensional fatigue inventory (MFI-20), Chalder fatigue scale, Bell-score, … |
JULIA WEINMANN-MENKE; | 2023-05-08 |
| 337 | A Bidimensional Early Intervention Strategy of Standard of Care Combined With Host Immunomodulation in Elderly Patients With Mild or Moderate COVID-19: A Multicentre, Randomized, Controlled, Adaptive Platform Study PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is aimed to explore the dual-dimensional early intervention strategy of standard of care combined with host immunomodulation in elderly patients with mild and moderate COVID-19. |
WEN-HONG ZHANG; | 2023-05-05 |
| 338 | The Technical and Operational Performance of The QuidelOrtho Savanna RVP4 Analyzer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is for the research team to become familiar with and evaluate the technical and operational performance of the QuidelOrtho Savanna RVP4 analyzer by testing 120 archived specimens that were previously tested at the Wisconsin State Laboratory of Hygiene (WSLH) by RT-PCR and multiplex respiratory pathogen panel within the last year. |
JONATHAN TEMTE; | 2023-05-05 |
| 339 | Investigating Uptake and Subsequent Health Outcomes Associated With Pfizer-BioNTech Bivalent COVID-19/Influenza Vaccine Concomitant Administration Using A Claims-based Real-world Data Source in The US Related Papers Related Patents Related Grants Related Experts View Highlight: This study intends to describe the characteristics of patients given the Pfizer-BioNTech bivalent mRNA COVID-19 vaccine and any commercially available influenza vaccines at the same time versus at different times. |
PFIZER | 2023-05-05 |
| 340 | A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine The Safety and Effectiveness of Azeliragon in The Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A new drug called azeliragon could be used to treat patients with COVID-19 or other pneumonia infections but the researchers don’t know. In this study, they are learning the effects of azeliragon patients hospitalized for COVID-19 or pneumonia. |
LUCAS S. BLANTON; | 2023-05-04 |
| 341 | EFFECT OF COGNITIVE BEHAVIORAL THERAPY ON DEPRESSION AND QUALITY OF LIFE IN PATIENTS WITH POST COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test the effect of Rehacom on depression and Quality of life in post covid -19 patients. The main question it aims to answer is: • Is a cognitive rehabilitation therapy will improve depression and quality of life in patients with post COVID-19? Researchers will compare Rehacom with exercise therapy to see if rehacom can improve depression and quality of life in patients with post COVID-19 neuropsychological problems. |
ALLAA ASHRAF MAHER MOHAMMED ELFWEY; | 2023-05-04 |
| 342 | Promoting Protection of Others to Increase Future COVID-19 Booster Shot Vaccination Intentions in Younger Adult Canadians: Evaluating The Efficacy of Short Video-based Interventions PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: While COVID-19 vaccine uptake has generally been high in Canada, with 83.4% of the total population having received the first two doses (i.e., primary series), additional booster uptake has been slower, especially among young adults aged 18-39. Throughout the pandemic, young adults have experienced less personal risk from COVID-19 infection and this has led to lower motivation to vaccinate when it is recommended. Achieving high rates of up-to-date vaccine coverage is important in this group to anticipate new variants and waves of infection and changes to recommendations which might include annual or seasonal vaccination. Three video interventions, … |
ZEEV ROSBERGER; | 2023-05-01 |
| 343 | Digital Mental Health Care for COVID-19 High-Risk Populations – Phase 2 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The mental health consequences of the COVID-19 (Coronavirus Disease of 2019) pandemic are likely to be vast, exceeding the capacity of mental health services and delaying treatment for people in need, with devastating consequences for those affected. Emerging data suggest that frontline health workers (e.g. physicians, nurses, emergency medical technicians) and essential workers (in industries such as energy, and food products and services) face particular risks for mental health problems during and after the COVID-19 outbreak. Additionally, our previous findings have shown that among these higher risk individuals, … |
YUVAL Y NERIA; | 2023-05-01 |
| 344 | Clinical Validation of The LumiraDx SARS-CoV-2 & Flu A/B Test in Anterior Nares Nasal Samples For Point-of-Care (POC) Use PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective multicenter study conducted to evaluate the performance of the LumiraDx SARS-CoV-2 & Flu A/B tests at point of care sites. Subjects presenting with symptoms suggestive of coronavirus disease 2019 (COVID-19) and Influenza at the time of the study visit will be enrolled and asked to donate swab sample(s) for testing on the device under evaluation. |
RANDALL QUINN; | 2023-05-01 |
| 345 | Factors Associated With Failure of HFNO in COVID-19 ICU Patients PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine the factors associated with OHD failure in COVID-19 patients admitted to an Intensive Care Unit |
CENTRAL HOSPITAL NANCY FRANCE | 2023-05-01 |
| 346 | An Interventional, Double-Blinded, 2-Arm Study to Investigate The Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared With Placebo/Ritonavir in Non-hospitalized Adult Participants Suffering From Post-COVID PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with placebo/ritonavir to improve quality of life in non-hospitalized adult participants suffering from post-acute COVID-19 syndrome. |
PETTER BRODIN; | 2023-05-01 |
| 347 | Rural Tailored COVID-19 Communication and SARS-CoV-2 Antibody Testing Evaluation and Uptake PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to evaluate communication strategies for better encouraging understanding and uptake of salivary SARS-CoV-2 antibody testing among individuals residing in rural Northern Michigan. This iteration will consider individuals recruited from rural Northern Michigan and assess their willingness to participate in home-based saliva sample collections. |
TODD LUCAS; | 2023-05-01 |
| 348 | Digital Rehabilitation With Cognitive Training, Physical Activity and Mindfulness for People With Post-acute COVID-19 Syndrome With Cognitive Impairment. REHABCOVID Project PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Although most infected people survive the infection, many have persistent sequelae or symptoms, which cause disability or decreased quality of life. The World Health Organization has called on countries to prioritize the rehabilitation of the consequences of COVID-19 in both the medium and long term, as this chronicity is expected to impact the health public and the economy in the coming years. RehabCOVID (also referred to as RehabNautilus) is born from the need to provide solutions to persistent cognitive impairment symptoms of people who have suffered from COVID-19. Thus, … |
MAITE GAROLERA; | 2023-05-01 |
| 349 | PATienT ExperieNces WiTh CovId FOllow-up Clinic PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: People who are older, those who had underlying other health conditions and people living in poorer communities are at increased risk of complications and worse outcome from COVID-19. They are more likely to be admitted to hospital with this virus. In the UK in 2020, over 130,000 people were admitted to hospital with COVID-19. Whilst admission rates fell since then, there is a need to understand better the potential impact of the many symptoms resulting from a COVID-19 infection on patients and the health services. To achieve this, … |
UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST | 2023-05-01 |
| 350 | Effect of Telerehabilitation Practice in Long COVID-19 Patients: Impact on Stress Oxidative, Inflammation, Functional Capacity and Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test the efficacy of telerehabilitation practice in Long COVID-19 patients. The main question[s] it aims to answer are whether telerehabilitation practice in Long COVID-19 patients help to reduce stress oxidative, reduce inflammation, improve functional capacity and improve quality of life. Participants will receive 12 weeks of telerehabilitation practice Researchers will compare intervention group (that received telerehabilitation) and control group (that received standard treatment) to see if there is better outcome in intervention group. |
NURUL PARAMITA; | 2023-05-01 |
| 351 | A Pilot Study Evaluating The Efficacy of The Vielight Neuro RX Gamma in The Treatment of Post COVID-19 Cognitive Impairment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Some people who have been infected with the virus that causes COVID-19 can experience long-term effects from their infection, known as post COVID-19 conditions (PCC) or long COVID1. The medical circles often describe it as post-acute sequelae of Covid-19 (PASC). People with post-COVID conditions can have a wide range of symptoms that can last more than four weeks or even months after infection. Sometimes the symptoms can even go away or come back again. The Centers for Disease and Prevention (CDC) listed a constellation of 19 symptoms related to post COVID-19. In research, … |
VIELIGHT | 2023-05-01 |
| 352 | Impact of Meditation on Reducing Stress in Glaucoma Patients During COVID-19 Pandemic: An Electronic Pilot Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Visually impaired seniors are susceptible to having lower Quality of Life (QOL)1-4. The current situation-specific stressors including the fear of contracting COVID-19, prolonged periods of self-isolation, reduced mobility, greater dependence on caregivers or family members, reduced or no social interactions, inability to visit clinics for non-emergency treatments and surgeries, and financial uncertainty may further deteriorate the QOL of seniors with eye diseases. In this study, … |
LAWSON HEALTH RESEARCH INSTITUTE | 2023-05-01 |
| 353 | Assessing The Efficacy and Safety of Yinqiaosan-Maxingganshitang in The Treatment of The Major Symptoms of Mild and Moderate COVID-19 By Telemedicine – A Randomized, Double-blind, Placebo-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blinded, placebo-controlled clinical trial. This study is to evaluate the effectiveness and safety of Yinqiaosan-Maxingganshitang in the treatment of the major symptoms of mild and moderate COVID-19 patients by telemedicine. |
LIN ZHIXIU; | 2023-05-01 |
| 354 | Colostrum from MERS-CoV Seropositive Camels for SARS-CoV-2 Infection – from Lab to Human- A Placebo Controlled Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to study the efficacy of colostrum from MERS-CoV-positive camels applied as a nasal spray to COVID-19 patients for treatment and prevention of SARS-CoV-2 infection. This study will compare the usage of colostrum to placebo. |
HILA ELINAV; | 2023-05-01 |
| 355 | Communication in The Hospital: Impact on Patients With Alzheimer’s Disease and Other Causes of Cognitive Impairments and Their Surrogate Decision Makers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study of scheduled video/audio conferences by clinical navigators on the experience of surrogate decision makers for hospitalized older adults with Alzheimer’s disease (AD), delirium, and other causes of cognitive impairment. The purpose of this study is to learn more about the experiences of surrogate decision makers of hospitalized older adults when they cannot be physically present with the patient in the hospital. We will conduct a randomized pilot study of virtual visits to connect the surrogate decision makers of incapacitated, hospitalized older adults with AD, delirium, … |
ALEXIA M. TORKE; | 2023-05-01 |
| 356 | COVID-19 Vaccination Detoxication in Low Density Lipoprotein Cholesterol Related Papers Related Patents Related Grants Related Experts View Highlight: The study hypothesizes that SARS-CoV-2 vaccination poisoning hibernates in human host in Low Density Lipoprotein Cholesterol (LDL-C). The clinical trial is a follow-up from the intervention trial with NCT number NCT05711810. It tests the use of Atorvastatin Calcium Tablets for detoxification and prevention of blood acidification, and the use of the Chinese herb compounded Anti-Viral Granules for the detoxification in the endocrine system. |
YANG I. PACHANKIS; | 2023-05-01 |
| 357 | A Randomised, Double-Blind, Dose-Escalation Phase I Study in Healthy Adults to Assess The Safety, Tolerability and Immunogenicity of Glycovax-002, A Novel Vaccine Candidate Against COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Glycovax Pharma has developed a glycoconjugate vaccine candidate called Glycovax-002 to fight the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the origin of COVID-19. The aim of the study is to assess the safety, reactogenicity and immunogenicity of Glycovax-002 in humans. The study is a phase I, placebo-controlled, dose-escalation study conducted in 36 healthy females and males aged between 18 and 55 years old. The vaccine will be administered three times with a two-week time interval between each dose. Dose escalation is conducted in three steps. At each step, … |
KRISTI MCLENDON; | 2023-04-28 |
| 358 | To Evaluate The Safety and Immunogenicity Following A Heterologous Booster Dose of Recombinant SARS-CoV-2 Trivalent Vaccine (CHO Cell) LYB002 in Chinese Adults 18 Years and Above Completed Three-dose Inactivated COVID-19 Vaccine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety, humoral immunogenicity, cellular immunogenicity and immune persistence following a heterologous booster dose of recombinant SARS-CoV-2 trivalent vaccine (CHO Cell) LYB002 in Chinese adults 18 years and above completed three-dose Inactivated COVID-19 vaccine; |
XIAOLAN YONG; | 2023-04-25 |
| 359 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Individuals affected by SARS-CoV-2 infection may subsequently be affected by the so-called post-COVID syndrome. The aim of the present study is to investigate the effects of a multimodal 10-week group program consisting of self-help strategies based on complementary medicine approaches of TEM (Traditional European Medicine), TCM (Traditional Chinese Medicine), and TIM (Traditional Indian Medicine) in addition to treatment as usual versus treatment as usual alone (no active study intervention/waiting list). Endpoints of the study include subjective quantitative and qualitative as well as objective (physician-reported) variables. |
HEIDEMARIE HALLER; | 2023-04-25 |
| 360 | MYocarditis And/or Pericarditis Following MRNA COVID-19 VACCination National Surveillance Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Myocarditis is inflammation of the heart muscle. Pericarditis is inflammation of the lining surrounding the heart muscle. Symptoms of these conditions can include pain in the chest and rapid or irregular heartbeat. There are many different causes for myocarditis and pericarditis including COVID-19 infection. The MYCOVACC study will identify patients using local screening strategies, including research communications, care provider referrals, … |
NATHANIEL HAWKINS; | 2023-04-23 |
| 361 | Enhancing SARS-CoV-2 Rapid Testing Acceptance in Latinx Communities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The ongoing Oregon Saludable: Juntos Podemos (OSJP, Healthy Oregon: Together We Can) project was developed to directly address the COVID-19 related health disparities among Latinx communities through community engagement funded by Phase I and II of the RADx-UP initiative. This project is organized by the University of Oregon’s Oregon Saludable: Juntos Podemos (OSJP) project. In this Phase III study, … |
DAVE DEGARMO; | 2023-04-22 |
| 362 | A Randomized, Double-Blind, Sham Controlled, Stratified, Pivotal Efficacy and Safety Study of The EmitBio RD-X19 Treatment Device in Individuals 40 Years of Age and Older With Mild COVID-19 in The At-Home Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind, sham controlled, stratified, pivotal efficacy and safety study of the EmitBio RD-X19 treatment device in Individuals 40 Years of age and older with Mild COVID-19 in the at-home setting. |
EMITBIO | 2023-04-21 |
| 363 | A PHASE 2B, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL GROUP, DOSE RANGING STUDY TO EVALUATE VIROLOGICAL RESPONSE AND SAFETY OF ORAL PF-07817883 IN NON-HOSPITALIZED SYMPTOMATIC ADULT PARTICIPANTS WITH COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to understand the effects and safety of PF-07817883 treatment. The study wants to know how PF-07817883 treatment lowers the level of the virus that causes COVID 19. To understand that samples are collected from adult participants who have the symptoms of COVID 19 but are not hospitalized. The study is seeking for participants who: – are 18 years of age or older at the time of entering the study. – … |
PFIZER | 2023-04-21 |
| 364 | The Utility of Lollipop Oral Swabs in The Diagnosis of COVID-19 in An Inpatient Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to see if collecting saliva samples with a lollipop collection method works as well as nasopharyngeal samples for COVID-19 polymerase chain reaction (PCR) testing. 225 COVID-positive participants aged 4 years and above admitted to a hospital in the Madison, Wisconsin metropolitan area will be enrolled over a 6 month period. |
ELLEN WALD; | 2023-04-20 |
| 365 | A Double-blind, Randomized, Parallel Design Study to Compare Postoperative Recovery Between The Sugammadex Group and The Neostigmine Group in Patients After COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Researcher want to compare and evaluate the effect of sugammadex on postoperative recovery, with a focus on the occurrence of postoperative urinary dysfunction, in patients who have undergone regular abdominal surgery within a year of being infected with and treated for COVID-19. Post COVID-19 condition is a new and poorly understood clinical syndrome with potentially significant and life-altering consequences. Recent studies suggest that patients who have recovered from COVID-19 may experience autonomic dysfunction and be at risk for autonomic dysregulation/syndrome. In most patients undergoing general anesthesia, neuromuscular blockers are used, … |
KOREA UNIVERSITY ANSAN HOSPITAL | 2023-04-20 |
| 366 | A PHASE 1 RANDOMIZED, ACTIVE-CONTROLLED, DOUBLEBLIND, SINGLE CENTRE STUDY TO EVALUATE THE SAFETY AND IMMUNOGENICITY OF AN ADJUVANTED SARS-CoV-2 UQSC2 PROTEIN SUBUNIT VACCINE IN HEALTHY ADULTS, AGED 18 TO 50 YEARS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This will be a single centre, Phase 1, First-In-Human , Randomized, Active-controlled (2- arm) Double-blind, single dose, parallel design study. The study will be conducted in a young healthy adult population aged ≥ 18 – ≤ 50 years. This study will consist of a single cohort of 70 subjects (35 receiving a single dose of UQSC2 vaccine and 35 subjects receiving a single dose of a TGA (Therapeutic Goods Administration) registered SARS-CoV-2 vaccine NVX-CoV2373). |
KRISTI MCLENDON; | 2023-04-20 |
| 367 | A Novel Nasal Treatment for COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to test an investigational new inhaled medication called Optate. |
JAMES F. CHMIEL; | 2023-04-20 |
| 368 | Prospective Clinical Evaluation of The Labcorp COVID-19+Flu+RSV Test Home Collection Kit As Offered Commercially By Labcorp – A Registry Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the results obtained by analysis of a self-collected anterior nasal (AN) swab as part of the Labcorp COVID-19+Flu+RSV Test Home Collection Kit to a healthcare provider (HCP)-collected AN swab in patients with symptoms of viral respiratory infection consistent with influenza A (Flu A), influenza B (Flu B), respiratory syncytial virus (RSV) and/or SARS-CoV-2 (C-19). |
SEQUENOM | 2023-04-17 |
| 369 | Examining The Immunomodulatory and Health Improving Function of A Chinese Medicine Nutritional Supplement Cs4 on Immunity-related Disorders in The Post-COVID Era PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cordyceps is a medicinal Chinese medicine. The benefits of cordyceps-related therapeutic action have been studied due to its anti-inflammation and immunomodulation features. Thus, Cordyceps may have efficacy against inflammation-related health problems in the post-COVID era. the Cs4 is a Chinese medicine nutritional supplement fermented by Cordyceps. This Project conducts a two-stage waitlist-controlled trial to examine the therapeutic effect of the Cs4 on long-COVID patients. 110 Patients will be recruited and divided into two groups. Each group contains 55 patients. In the first-stage clinical trial for 12 weeks, … |
FENG YIBIN; | 2023-04-17 |
| 370 | Immunogenicity of COVID-19 Vaccines Against Coronavirus Disease (COVID-19) Among Tuberculosis (TB) Patients in Thailand-Myanmar Border PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a non-randomized observation and comparison of immune response between bacteriologically confirmed TB patients under treatment cohort who received COVID-19 vaccine (n=54) vs healthy individuals (n=54). Each participant will receive single or double doses of one of COVID-19 vaccines (Pfizer-BioNTech COVID-19 vaccine, … |
FRANÇOIS NOSTEN; | 2023-04-15 |
| 371 | Post-marketing Safety of Elasomeran/Davesomeran and Andusomeran Vaccines in The United States PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to evaluate the safety of the elasomeran/davesomeran and andusomeran vaccines as used in routine clinical practice. |
MODERNATX | 2023-04-14 |
| 372 | A Phase 1/2, Randomized, Observer-blind, Active-Control Study to Evaluate The Safety, Reactogenicity, and Immunogenicity of MRNA-based Influenza and SARS-CoV-2 Multi-component Vaccines in Healthy Adults PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to generate sufficient safety, reactogenicity, and immunogenicity data to enable selection of an mRNA-1083 vaccine composition and dose level to evaluate in a subsequent Phase 3 clinical trial in adults. |
MODERNATX | 2023-04-14 |
| 373 | Evaluate The Effectiveness for Long-term Consequences of COVID-19 of Mindfulness-based Stress Reduction (MBSR) and Cognitive Behavioral Therapy CBT PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The consequences of the Intensive Care Unit and the Covid-19 disease are still uncertain. However, many studies are bringing out often psychological and dramatic consequences for many COVID-survivor patients. Among the ex-covid patients discharged from our Intensive Care Unit and with at least one covid-related psychological consequence, we want to evaluate the effectiveness for long-term consequences of COVID-19 of mindfulness-based stress reduction (MBSR) and cognitive behavioral therapy (CBT) or usual care. |
VINCENZO DAMICO; | 2023-04-13 |
| 374 | Butterfly (IVD -TAQPATH V1 510K) – Clinical Performance Study Protocol – PRJ0003622 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This prospective clinical performance study is a non-interventional, multi-center study to evaluate the assay performance of the COVID-19 test using upper respiratory specimens. Prospectively collected nasopharyngeal and anterior nasal swabs will be collected from each participant recruited in the study. |
THERMO FISHER SCIENTIFIC | 2023-04-12 |
| 375 | Efficacy of Teletechnology-assisted Home-based Exercise Program for Severe COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to investigate the efficacy of a home-based pulmonary rehabilitation program with the support of teletechnology in COVID-19 survivors. The main questions it aims to answer are: – The change of six-minute walk distance – The change of time of one-minute sit-to-stand test – The change of maximal strength of upper-limb, lower-limb and respiratory muscle – The change of quality of life Participants in the home-based pulmonary rehabilitation group will receive teletechnology-assisted consultations (either by videotelephony or telephone calls) for every 1-2 weeks during the intervention period, … |
PING-LUN HSIEH; | 2023-04-12 |
| 376 | Pilot Study Evaluating The Feasibility and Appropriateness of A Telerehabilitation Exercise Program in People With Post-COVID-19 Sequelae: A Single-center Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study pilot randomized controlled study is to evaluate the feasibility of the study procedures and to compare the preliminary efficacy of a rehabilitation program given in a remote (telerehabilitation) or face-to-face model for adult patients who had confirmed SARS-CoV-2 infection and still have symptoms after eight weeks of infection. The main question it aims to answer is: * Are the study procedures feasible? * Will the two groups have similar results for the preliminary efficacy outcomes? Researchers will compare group telerehabilitation to a face-to-face group to see if it’s comparable. Participants will: * Take part in a 60-minute training session, 3 times a week in person or remotely * Visit the clinic before starting the training program and after 8 weeks of training * Keep a diary of their symptoms, if any |
MARIE-CLAUDE LEHOUX; | 2023-04-07 |
| 377 | The Effect of An Active Break Intervention on Nonspecific Low Back Pain and Musculoskeletal Discomfort During Prolonged Sitting Among Young People (SPINE-have&Care) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The most recent evidence showed that the COVID-19 (coronavirus disease 2019, National Institutes of Health) pandemic caused an increase in low back pain (LBP) prevalence and intensity among young people. This may be explained by the prolonged sitting time, next to reduced level of physical activity. Young people spend most of their time in a sitting position while studying (in school class, during homework) and using electronic devices (using the computer, laptop, mobile phone, tablets, or watching TV), and now using e-learning methods. E-learning, and thus prolonged sitting, … |
MAGDALENA PLANDOWSKA; | 2023-04-04 |
| 378 | Evidence Driven Indoor Air Quality Improvement PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim is to identify the underlying disease mechanisms driving specific asthma phenotypes as well as certain disease outcomes and their relation to impaired indoor air quality. This may also help in underpinning specific target mechanisms in order to personalize and improve current treatment options in childhood asthma and develop more successful prevention strategies. This will be done by combining data from detailed clinical phenotyping with multiple -omics data. |
MIRJANA TURKALJ; | 2023-04-03 |
| 379 | Study on The Influence of Corona Virus Disease 2019 on Obstetric Outcome and Offspring Development PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the influence of Corona Virus Disease 2019 on obstetric outcome and offspring development. |
YINUO SONG; | 2023-04-01 |
| 380 | A Phase 2 Trial of The Immunogenicity and Safety of CVXGA1 Intranasal COVID Vaccine in Healthy Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this trial is to evaluate immunogenicity of CVXGA1 administered in a single intranasal dose against SARS-CoV-2 S-protein in participants with or without prior receipt of COVID vaccine and with or without history of prior COVID infection. The trial population includes 400 healthy participants, age 18-55 years, that will be asked to complete 4 clinic visits and 1 follow-up phone call. |
CYANVAC | 2023-04-01 |
| 381 | SARS-CoV-2/COVID-19 Study of Next Generation Non-Invasive Passive Detection Technologies PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to evaluate new non-invasive passive surveillance technologies, Level 42 AI imPulse™ for the detection of COVID-19 in asymptomatic and symptomatic individuals over age of 18 undergoing COVID-19 screening and testing at BAMC Ft Sam Houston, TX; with and without COVID-19. The hypotheses are: (H1) The imPulse™ Una e-stethoscope has at least a similar discriminative and detection ability among symptomatic and asymptomatic COVID-19 carrier versus those not infected compared to gold standard RT-PCR. Based on these promising studies, … |
TONY T YUAN; | 2023-04-01 |
| 382 | A Multi-center, Randomized, Parallel Controlled, Double-Blinded Clinical Trial to Evaluate The Effectiveness and Safety of Hydrogen-Oxygen Generator With Nebulizer for Adjuvant Treatment of Novel Coronavirus Disease 2019 (COVID-19) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, parallel controlled, double-blinded clinical trial to evaluate the effectiveness and safety of Hydrogen-Oxygen Generator with Nebulizer for adjuvant treatment of COVID-19 patients. The test group is expected to be superior to the control group in the primary endpoint (percentage of subjects achieving clinical recovery at Day 7 of study treatment). Subjects in the test group will receive treatment by using Hydrogen-Oxygen Generator with Nebulizer (manufactured by Shanghai Asclepius Meditec Co., Ltd., flow rate: 3L/min) combined with conventional basic supportive treatment (symptomatic support treatment determined by the investigator based on the condition of the subjects); … |
WEIJIE GUAN; | 2023-04-01 |
| 383 | Anxiety, Depression, Immune Function and Quality of Life Among Chinese Liver Cancer Patients in The COVID-19 Pandemic Era PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this cross-sectional study is to investigate the prevalence and risk factors of anxiety and depression and their relationships with immune functions and quality of life among liver cancer patients in the COVID-19 pandemic era. The objectives of this study are: 1. To examine the prevalence of anxiety and depression among patients with liver cancer during the COVID-19 pandemic. 2. To identify risk factors associated with anxiety and depression among these patients. 3. To determine the association between anxiety, depression, immune function, … |
HUA YIN; | 2023-04-01 |
| 384 | Characterization of The Immunometabolic Signature in Long COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to identify immunometabolic signatures associated with Long COVID in plasma and peripheral blood mononuclear cells (PBMC). |
VINCENT DUBEE; | 2023-04-01 |
| 385 | Effect E-health Based Exercise Intervention After COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Reduced subjective and objective functional capacity performance are reported after COVID-19 in a large proportion of subjects. The aim of this study is to examine the feasibility and effect of using an e-health tool for guidance and tracking of exercise training in a general population of adults previously infected by COVID19. |
DORTHE STENSVOLD STENSVOLD; | 2023-04-01 |
| 386 | Satisfaction Survey on The Tolerability of Surgical Masks for Protection Against The Spread of SARS-CoV2 in Patients With Chronic Respiratory Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is conducted in the context of the COVID-19 pandemic in general, and more specifically in the context of the evaluation of the use of protective masks as a barrier to the spread of the virus. The wearing of masks is one of the recommended barrier measures to limit the spread of the SARS-CoV-2 virus responsible for COVID-19. It is recommended in all circumstances, and mandatory in some. Regardless of the type of mask used (noting that the so-called surgical masks are by far the most common), … |
THOMAS SIMILOWSKI; | 2023-04-01 |
| 387 | A Phase 1b/2a Randomized, Blinded, Placebo-controlled Study in Participants With Mild to Moderate COVID-19 to Evaluate The Safety, Efficacy, and Pharmacokinetics of Orally Administered ProLectin-M PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: ProLectin M is an orally administered polysaccharide. Polysaccharides competitively bind to the N-terminal tail of human galectin-3 through a proline isomerization [10]. Galetin-3 (Gal-3) is 1 among the 15 galectins described in humans and also a ubiquitous human galectin expressed in various disease pathogenesis pathways [11]. The objective of this clinical study is to evaluate the safety and efficacy of a galectin antagonist, ProLectin M (a Guar Gum Galactomannan), in the treatment of subjects with asymptomatic to moderately-severe, ambulatory COVID-19 patients. |
BIOXYTRAN | 2023-04-01 |
| 388 | Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells in The Treatment of Long COVID-19: A Randomized, Double-blind, Parallel-controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To explore the efficacy and safety of Umbilical cord mesenchymal stem cells in the treatment of long COVID-19 |
SHANGHAI EAST HOSPITAL | 2023-04-01 |
| 389 | Feasibility of ENGAGE to Address Social Isolation Related to The COVID-19 Pandemic PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-arm community-based feasibility study examining recruitment, retention, adherence, and satisfaction with ENGAGE, a community-based intervention designed to address pandemic-related social isolation among people with disabilities. We will also examine preliminary, within-group effects on social participation. The findings of this study will inform a larger trial to examine intervention efficacy. |
JOY M HAMMEL; | 2023-04-01 |
| 390 | A Practical, Pilot, Randomized, Controlled Trial of Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this research is to determine whether Valproate alone, and in combination with Quetiapine, lowers confusion and agitation in persons with severe Corona Virus Disease (COVID)19 pneumonia during weaning from the breathing machine (ventilator). Though Valproate and Quetiapine are often given to persons with severe confusion with agitation, the purpose of this small research study is specifically for: a) persons infected with COVID 2019 on a ventilator whose agitation is not responding to the usual medications (like dexmedetomidine), and b) to reduce the time persons are treated with dexmedetomidine, which requires continuous close monitoring in an ICU. |
DOMINIQUE MUSSELMAN; | 2023-04-01 |
| 391 | A Randomized, Placebo-Controlled Trial to Evaluate The Efficacy of Intranasal STI-9199 in Treating Symptomatic COVID-19 in Outpatient Adults and Adolescents Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2 global, randomized, double-blind, placebo-controlled study designed to investigate the safety and preliminary efficacy of intranasal STI-9199 in adults and adolescents who are COVID-19 positive with mild to moderate symptoms. |
SORRENTO THERAPEUTICS | 2023-04-01 |
| 392 | A Multicentric Randomized, Double-blind, Placebo-controlled Study to Assess The Safety and Efficacy of Centhaquine As An Adjuvant to The Standard of Care in COVID-19 Patients With Moderate to Severe Acute Respiratory Distress Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus causing coronavirus disease 2019 (COVID-19), which has been a global pandemic since March 2020. According to WHO, more than 289 million cases have been confirmed worldwide, with just over 5.4 million reported deaths as of January 2022. SARS-CoV-2 variants continue to emerge, with the omicron variant causing the increased surge in cases. Currently, Johns Hopkins University of Medicine reports a case fatality rate of 1.5% for the United States. COVID-19 infections may be asymptomatic in some cases, … |
PHARMAZZ | 2023-03-31 |
| 393 | A Single-center, Randomized, Double-blind, Controlled Clinical Trial to Evaluate The Safety and Immunogenicity of Booster Vaccination of Recombinant COVID-19 Variant Vaccine (Sf9 Cell) in Healthy People Aged 18 Years and Older PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A single-center, randomized, double-blind, controlled clinical trial to evaluate the safety and immunogenicity of booster vaccination of Recombinant COVID-19 variant vaccine (Sf9 cell) in healthy people aged 18 years and older after completing 2 or 3 doses of novel coronavirus inactivated vaccine (Vero cells) |
WESTVAC BIOPHARMA | 2023-03-30 |
| 394 | INHALEd Nebulised Unfractionated HEParin for The Treatment of Hospitalised Patients With COVID-19 (INHALE-HEP) Australia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigator-initiated, multi-centre, randomised, open-label trial of nebulised heparin sodium in addition to standard care compared to standard care alone in hospitalised patients with COVID-19 infection. |
FRANK VAN HAREN; | 2023-03-30 |
| 395 | A Registry Study of Patients Hospitalized With Confirmed COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The design of this registered study aims to evaluate the efficacy and safety of Paxlovid in the treatment of hospitalized COVID-19 patients, and to explore factors related to the efficacy and safety of Paxlovid. |
ZHANG YI; | 2023-03-30 |
| 396 | The Impact of COVID-19 on The Rate of Peri-operative Complications of Maxillary Sinus Floor Augmentation Procedure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The risk of Schneiderian membrane perforation and the postoperative complications of the sinus floor elevation surgery were evaluated for patients with and without history of COVID-19 infection. |
WALAA KADRY; | 2023-03-30 |
| 397 | A Randomized, Observer-Blind, Active-Controlled Phase 3 Study to Investigate The Safety, Immunogenicity, and Relative Vaccine Efficacy of MRNA-1283 Compared With MRNA-1273 in Participants Aged ≥12 Years for The Prevention of COVID-19 PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-1283.222 versus mRNA-1273.222 (Part 1) and mRNA-1283.815 versus mRNA-1273.815 (Part 2). |
MODERNATX | 2023-03-28 |
| 398 | A Phase III, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Safety and Efficacy of HH-120 Nasal Spray for Post-exposure Prophylaxis of SARS-CoV-2 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will assess the efficacy of HH-120 nasal spray in participants for the post-exposure prevention of SARS-CoV-2. |
HUAHUI HEALTH | 2023-03-28 |
| 399 | A Phase 3 Study to Evaluate The Immunogenicity and Safety of Novavax COVID-19 Vaccine(s) As Second or Subsequent Booster After MRNA Vaccines in Individuals 18 to 49 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label Phase 3 study evaluating the immunogenicity and safety of Novavax vaccine(s) with Matrix-M™ adjuvant (ancestral strain NVX-CoV2373 and an alternative strain and/or multivalent Novavax vaccine) as booster doses following a series of primary and booster doses of authorized/approved mRNA vaccines followed by a single booster dose of NVX-CoV2373 in the Novavax 2019nCoV-307 study (Study 307). |
NOVAVAX | 2023-03-28 |
| 400 | Effect of Different Types of Supervised Exercise Programs on Cardiorespiratory and Muscular Fitness, Pain, Fatigue, Mental Health and Inflammatory and Oxidative Stress Biomarkers in Older COVID-19 Survivors. (EJerSA-COVID-19) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Many patients with COVID-19 present the so-called post-acute sequelae of COVID-19 such as fatigue, post-stress discomfort, dyspnea, headache, pain mental impairment, incapacity to perform daily physical tasks ant exercise intolerance. This study aims to investigate the effects of different exercise programs on physical and mental fitness, physical condition and biomarkers of the immune system and oxidative stress in older COVID-19 survivors. Methods: The sample will be made up of 120 eligible participants, … |
MANUEL VICENTE GARNACHO CASTANO; | 2023-03-27 |
| 401 | A Multi-center, Randomized, Blinded, Placebo-controlled, Phase 3 Clinical Study to Evaluate The Efficacy, Safety and Immunogenicity of SARS-CoV-2 Bivalent MRNA Vaccine (LVRNA021) As Booster in Participants Aged 18 Years and Older Who Completed Primary/1 Booster Dose(s) of SARS-CoV-2 Vaccination PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, blinded, placebo-controlled, phase 3 clinical study to evaluate the efficacy, safety and immunogenicity of SARS-CoV-2 bivalent mRNA vaccine (LVRNA021) as booster in participants aged 18 years and older who completed primary/1 booster dose(s) of SARS-CoV-2 vaccination. |
AIM VACCINE | 2023-03-25 |
| 402 | Post COVID-19 Syndrome-the Correlation With Suboptimal Health Status and Its Changes of Pulse Diagnosis and Autonomic Nervous System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: COVID-19 has caused various long-term symptoms affecting different bodily functions. A study shows that traditional Chinese medicine can balance the human body disorder after a virus infection and restore health. The study proposes using pulse diagnosis and cardiac rhythm instruments for disease diagnosis and analysis, decomposing time domain pulse wave signals into different frequency ranges and calculating the spectral energy ratio and EP to quantify the patient’s pathological pulse. The method has been applied to pulse wave analysis of people with suboptimal health status, … |
TAIPEI VETERANS GENERAL HOSPITAL TAIWAN | 2023-03-23 |
| 403 | A Randomized, Double-blind, Placebo-controlled, Loaded Phase III Clinical Trial on The Efficacy and Safety of Mepozumab for Injection in The Treatment of Post-COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial was a randomized, double-blind, placebo-controlled, loading phase III clinical study. |
JIANGSU PACIFIC MEINUOKE BIO PHARMACEUTICAL | 2023-03-23 |
| 404 | Phase 1b, Randomized, Open-label Study to Evaluate The Safety, Tolerability, and Immunogenicity of RVM-V001 Only, RVM-V002 Only, or RVM V001 + RVM V002 (Co Administered As Separate Injections) in Healthy Adults Previously Vaccinated With An Inactivated Virus or MRNA-based COVID-19 Vaccine in Singapore PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase 1b, randomized, open-label, study to evaluate the safety, tolerability, and immunogenicity of RVM-V001 only, RVM-V002 only, or RVM V001 + RVM V002 (Co administered as Separate Injections) in healthy adults. The study will be conducted at one site in Singapore. |
BARNABY YOUNG; | 2023-03-22 |
| 405 | Occurrence of Long-Covid in Patients After Inpatient Rehabilitation Due to Acute Covid-19 Infection. How Easy Is It for Patients to Return to Everyday Life and Work After Inpatient Rehabilitation Due to Acute Covid-19-infection? PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the first study is to investigate how often a long Covid syndrome occurs after an inpatient rehabilitation due to previous hospitalization because of after acute Covid and whether there might be a connection with the severity during acute illness. 3 clusters of acute cases have been identified to be studied with regard to the long-term symptoms 1. Mild course (medication, … |
REHAZENTRUM WALENSTADTBERG | 2023-03-20 |
| 406 | Efficacy of Lianhua Qingwen in Treating Patients Infected With The Omicron Variant of The COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A retrospective analysis was conducted on patients infected with the Omicron variant of COVID-19 diagnosed from August 2022 to now. Patients were divided into observation groups and control groups according to whether or not oral Lianhua Qingwen granules were used. Through data analysis and follow-up, the effectiveness of Lianhua Qingwen in treating patients infected with the Omicron variant of COVID-19 was discussed. |
QIAN QI; | 2023-03-20 |
| 407 | A PHASE 1/2 STUDY TO ASSESS THE SAFETY AND IMMUNOGENICITY OF A BROADLY PROTECTIVE MRNA VACCINE JCXH-221 AGAINST SARS-CoV-2 INFECTION AND DISEASES PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about, test, and compare JCXH-221 in healthy volunteers. The main aims to answer are: – To assess the safety and tolerability of the JCXH-221 vaccine in healthy adult subjects – To identify an optimal dose for the JCXH-221 vaccine in healthy adult subjects – To assess the humoral immunogenicity of the JCXH-221 vaccine in healthy adult subjects – To characterize the cellular immunogenicity of the JCXH-221 vaccine in healthy adult subjects Participants for Phase I will be randomized to either JCXH-221 or placebo. In Phase 2, … |
IMMORNA BIOTHERAPEUTICS | 2023-03-20 |
| 408 | Safety and Effectiveness of Placental Derived Exosomes and Umbilical Cord Mesenchymal Stem Cells in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) Associated With The Novel Corona Virus Infection (COVID-19) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Recent advances have been made in prevention of the viral infection via vaccines but there is still need for effective treatment options for patients. Novel therapies need to be developed to further improve clinical outcomes. The biggest medical challenge in the response to COVID-19 is ARDS requiring hospitalization in an intensive care setting and ventilator dependence. Intravenously administered umbilical cord derived exosomes and stem cells have been reported in literature to alleviate pulmonary distress in such patients. The purpose of this study is to explore the safety and benefits of intravenous administration of WJPure and EVPure in the treatment of COVID-19 patients with moderate to severe ARDS. . |
VITTI LABS | 2023-03-20 |
| 409 | Main Postoperative Complications After SARS-CoV-2 Infection: A Retrospective Cohort Study PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: To explore the relationship between SARS-CoV-2 infection in different time before operation and postoperative main complications (mortality, main pulmonary and cardiovascular complications) 30 days after operation; To determine the best timing of surgery after SARS-CoV-2 infection. |
RENJI HOSPITAL | 2023-03-19 |
| 410 | Lifestyle Changes By The COVID-19 (Coronavirus Disease 2019) Pandemic in Children With Developmental Delays PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the lifestyle changes caused by the COVID-19 pandemic in children with developmental delays in Taiwan. |
RU-LAN HSIEH; | 2023-03-19 |
| 411 | Retrospective Clinical Study of COVID-19 Associated With The Condition and Treatment of Patients With Chinese Psoriasis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A retrospective analysis based on database was conducted to evaluate the correlation between covid-19 infection and the condition and treatment of psoriasis patients. |
GANG WANG; | 2023-03-15 |
| 412 | Efficacy of Exercise-based MHealth Intervention for Patients With Post-acute COVID-19 Syndrome Based on Fatigue, Fitness, Post-exertional Dyspnea, Pain, Anxiety, Depression, Cognitive Function, and Quality of Life: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-Acute Syndrome COVID-19 is a disease resulting from infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is estimated that between 10 and 35% of infected persons suffer symptoms afterwards, and in hospitalized patients it can reach 85%. These sequelae have individual, social and economic repercussions, so effective rehabilitation alternatives are necessary. Physical exercise is recommended as rehabilitation for these patients. Moreover, the implementation of m-Health supported interventions is a proven alternative in patients with Post-Acute COVID-19 Syndrome or other conditions, which improves therapeutic adherence and patient autonomy. Therefore, … |
JOSE A. MORAL-MUNOZ; | 2023-03-15 |
| 413 | Prospective Cohort Study to Determine The Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The COVID-19 global pandemic killed more than 6 million people worldwide. Several vaccines have been developed against the virus that causes this disease. These vaccines are effective at preventing severe symptoms and death from COVID-19. Some people with chronic liver disease, especially those with an advanced condition called cirrhosis, … |
MARC G GHANY; | 2023-03-15 |
| 414 | A Phase 1/2, Randomized Double-blind Placebo-Controlled Trial to Test The Safety and Antiviral Activity of ACE2 Chewing Gum on SARS-CoV-2 Viral Load (COVID 19) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized double-blind, placebo controlled clinical trial of the safety, tolerability, and antiviral activity of angiotensin-converting enzyme 2 (ACE2) chewing gum over a 3-day period in non-hospitalized subjects with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. |
UNIVERSITY OF PENNSYLVANIA | 2023-03-15 |
| 415 | Covid-19 Vaccine Boosting in A Real World Setting: Exploratory Phase 3, Cohort Randomized, Single-blind, Multi-center Study to Evaluate The Safety and Immunogenicity of A Booster Dose of Various Covid-19 Vaccines in Fully Covid-19 Vaccine-primed Subjects Regardless of The Number of Prior Booster Dose(s) Received PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: SARS-CoV-2 is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, collectively known as COVID-19. Given the relatively short duration of protection after vaccination or SARS-CoV-2 infection and the evolution of immune-evading strains, it is likely that the population will have to be repeatedly boosted until a universal Pan-Sarbecovirus vaccine is available. SARS-CoV-2 protein subunit vaccine candidates have shown that, despite adjuvantation, their safety/reactogenicity profile seems to be preferable over mRNA or vectored vaccines, whilst inducing non-inferior immune responses (1,2). In this regard, … |
D’OR INSTITUTE FOR RESEARCH AND EDUCATION | 2023-03-14 |
| 416 | A Randomized, Parallel Controlled, Double-blind, Single-center Phase I Clinical Trial of Recombinant COVID-19 Variant Vaccine (Sf9 Cell)(WSK-V102) in People Aged 18 Years or Older PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Subjects aged 18 and above who have been completed primary or booster vaccination of COVID-19 inactivated vaccines for 3 months or more, to conduct a randomized, parallel controlled, double-blind, single-center phase I clinical trial of Recombinant variant COVID-19 vaccine (Sf9 cell)(WSK-V102) to evaluate the safety, tolerance and immunogenicity of this vaccine in the study population. |
WESTVAC BIOPHARMA | 2023-03-14 |
| 417 | Effect Of Kinesio Tape Versus Diaphragmatic Breathing Exercise In Post COVID-19 Patients(A Comparative Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: According to WHO, current evidence suggests some people experience a variety of long-term effects after they recover from their initial illness. These effects are collectively known as post COVID-19 condition or long COVID. While most people who develop COVID-19 fully recover, some people develop effects like fatigue, breathlessness, functional activities and cognitive dysfunction. At present, there is no specific medication therapy for people with post COVID-19 condition. |
ABDALLAH SALAH ABDALLAH GABR; | 2023-03-11 |
| 418 | A Multi-Centre, Prospective, Observational Post-Marketing Surveillance to Investigate The Long-Term Safety of SPIKEVAX BIVALENT and SPIKEVAX X Injection Under Routine Clinical Care in Korea PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the surveillance is to evaluate the incidence of the adverse events (AEs), and other safety related information in South-Korean population. |
MODERNATX | 2023-03-10 |
| 419 | A Randomised, Blinded, Parallel-controlled Phase 1 Clinical Trial to Evaluate The Safety and Preliminary Immunogenicity of A COVID-19 MRNA Vaccine in Healthy Adult Subjects PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomised, blinded, parallel-controlled phase 1 clinical trial to evaluate the safety and preliminary immunogenicity of a COVID-19 mRNA vaccine in a healthy population aged 18 years and older, and to investigate immunisation doses. |
CNBG VIROGIN BIOTECH SHANGHAI | 2023-03-10 |
| 420 | A Phase IIb, Randomized, Double-Blinded Trial to Evaluate The Immunogenicity and Safety Study of The Booster Dose Using The High or Medium Dose of COVID- 19 Vaccine (Vero Cell), Inactivated in Healthy Adults Who Have Completed Two Doses of MRNA Vaccine in Hong Kong PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blinded, Phase IIb clinical trial of COVID-19 vaccine (CoronaVac®) manufactured by Sinovac Research & Development Co., Ltd.The purpose of this study is to evaluate to evaluate the changes in immunogenicity before and after the booster vaccine using the high (1200 SU) or medium (600 SU) dose of COVID-19 Vaccine (Vero Cell), Inactivated. |
IVAN FAN NGAI HUNG; | 2023-03-10 |
| 421 | A Randomized, Double-blind, Placebo-controlled Phase II Clinical Study to Evaluate The Efficacy and Safety of WPV01 in Patients With Mild/Moderate COVID-19 Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Change of viral load compared to the baseline the percentage of patients who progressed to severe/critical COVID-19 or death from any cause … |
HAINV GAO; | 2023-03-10 |
| 422 | DisCOVEries 2 – An Observational Study to Evaluate The Immunogenicity of A COVID-19 Bivalent Booster As The Second Booster Dose Against Omicron BA.4/5 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to analyze binding antibody levels in adults in the United States (US) after receiving coronavirus disease 2019 (COVID-19) bivalent boosters. |
MODERNATX | 2023-03-08 |
| 423 | A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate The Efficacy and Safety of QLS1128 Orally in Symptomatic Participants With Mild to Moderate COVID-19 PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase 3 Study to Evaluate the Efficacy and Safety of QLS1128 Orally in Symptomatic Participants With Mild to Moderate COVID-19 |
QILU PHARMACEUTICAL | 2023-03-07 |
| 424 | Treatment of Perianal Fistulas in Crohn’s Disease With Autologous Microfragmented Adipose Tissue With The Lipogems® System PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to verify the efficacy of microfragmented autologous adipose tissue with the Lipogems® system, in the treatment of perianal fistulas of m. Crohn’s. The Lipogems® International, Milan, Italy, system is a sterile and disposable device that allows to harvest adipose tissue, process it and use it for intraoperative autologous transplantation of human adipose tissue mesenchymal cells that have a gene expression profile and phenotypic similar to that of adipose stem cells. The system consists of a container with metal beads capable of carrying out, by handling, … |
FABIO MARINO –; | 2023-03-07 |
| 425 | Safety, Pharmacokinetics, and Preliminary Efficacy of Herbal Products for The Treatment of Acute Respiratory Viral Infections Including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Uganda; Phase 2A Open Label Clinical Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The trial Safety, Pharmacokinetics and Preliminary Efficacy of herbal products for the treatment of acute respiratory viral infections including SARS-CoV2 in Uganda; Phase 2A Open Label Clinical Trial is currently being implemented under the Clinical Trials of Natural therapeutics Program. The trial sample size is 510, and the participants include adults (18 years or more) who fulfill the case definitions of acute respiratory infections (ARI), test positive for one of the target respiratory viruses, are negative for TB on GeneXpert; non-pregnant/non-breast-feeding females, have no history of hypersensitivity to any of the investigational products, … |
BRUCE J KIRENGA; | 2023-03-03 |
| 426 | Combined Molecular Testing for Influenza, SARS-CoV-2, and RSV RNA From Different Upper Airway Specimens PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a comparative prospective diagnostic accuracy study reported according to the STARD guidelines. Citizens at an outpatient COVID19 test facility at Testcenter Danmark Valby will be invited to participate in the study on a volunteer basis. The enrolled participants will have the planned oropharyngeal swab performed in the test center and sent for a SARS-CoV-2 RT-PCR test at TestCenter Danmark, Statens Serum Institut, Copenhagen, Denmark as usual. Besides the planned oropharyngeal swab performed in the test center, the participants will have additional specimens collected in form of saliva, nasopharyngeal-, nasal-, … |
TOBIAS TODSEN; | 2023-03-03 |
| 427 | Analysis of The Efficacy and Tolerance of Covid-19 Convalescent Plasma and Monoclonal Antibodies in The Treatment of SARS-Cov2 Infections in Immunocompromised Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Data on the use of convalescent plasma in the treatment of covid-19 are scarce: the results of randomized studies involving mainly immunocompetent patients are disappointing, while case series or retrospective data on more selected patients , in particular immunocompromised patients suggest a benefit in these patients whose clinical manifestation seems essentially related to the uncontrolled infection and not the cytokine storm. |
FRANÇOIS DANION; | 2023-03-02 |
| 428 | Effect of COVID-19 On Pain, Fear of Falling, Fall Frequency, and Physical Activity Level in The Elderly PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about in former COVID-19 patients. The main questions it aims to answer are: – are there any association among pain, fear of falling, fall frequency, and physical activity level – are there any difference between former COVID-19 elders and non-COVID-19 elderly population |
OZAN GÜR; | 2023-03-02 |
| 429 | Utilizing Wastewater Surveillance Data in A Communications Campaign to Boost Vaccination Uptake in New York State: A Comparison-control Trial PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the study is to determine the effect of a communications campaign sharing wastewater surveillance data to influence vaccine uptake in a metropolitan and non-metropolitan environment. The study will be conducted in Onondaga and Cayuga counties in New York State. Individuals of all ages within the selected counties, … |
SYRACUSE UNIVERSITY | 2023-03-01 |
| 430 | A Randomized, Double-blind, Parallel-controlled Phase III Clinical Trial to Evaluate The Efficacy and Safety of SCTV01E (Alpha/Beta/Delta/Omicron Variants S-Trimer COVID-19 Vaccine) in Population Aged ≥18 Years PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the effectiveness of SCTV01E in participants aged ≥18 years. |
SINOCELLTECH | 2023-03-01 |
| 431 | Clinical and Pathophysiological Characteristics of Postinfectious Cough Post COVID-19 Infection: A Multi-center Nationwide Research PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Collect the age, sex and other demographic data of 1600 patients with chronic cough after COVID-19 infection and clinical parameters such as cough characteristics, establish a cohort of patients with chronic cough after COVID-19 infection, observe the type and level of airway inflammation, airway responsiveness, cough sensitivity and changes in microbiology of patients with chronic cough after COVID-19 infection, clarify the epidemiological characteristics, clinical pathophysiological characteristics, long-term prognosis and related factors of patients with chronic cough after COVID-19 infection, explore the clinical pathophysiological characteristics and pathogenesis of cough after COVID-19 infection, … |
KEFANG LAI; | 2023-03-01 |
| 432 | Clinical Evaluation of The Panbio™ COVID-19/Flu A&B Rapid Panel Professional Use Device and The Panbio™ COVID-19/Flu A&B Rapid Panel Self-Test Device PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed as an international prospective, multicentric, clinical study to investigate the performance and usability of the Panbio™ COVID-19/Flu A&B Rapid Panel Professional Use and Self- Test devices for the qualitative detection of COVID-19 antigen, Influenza A antigen and Influenza B antigen in human nasopharyngeal (NP) and mid-turbinate nasal swabs, respectively. This study is part of the performance evaluation to support the CE conformity assessment procedures. |
ABBOTT RAPID DX | 2023-03-01 |
| 433 | Immunogenicity and Reactogenicity of The Beta-variant Recombinant Protein Booster Vaccine (VidPrevtyn Beta, Sanofi) Compared to A Bivalent MRNA Vaccine (Comirnaty Original/Omicron BA.4-5, BioNTech-Pfizer) in Adults Previously Vaccinated With at Least 3 Doses of COVID-19 MRNA Vaccine: A Non-inferiority Multicenter Single-blinded, Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this trial is to compare the immunogenicity and the safety of the Beta-variant recombinant protein booster vaccine (VidPrevtyn® Beta, Sanofi) to a bivalent mRNA vaccine (Comirnaty Original/Omicron BA.4-5, BioNTech-Pfizer) in adults previously vaccinated with at least 3 doses of COVID-19 mRNA vaccine. The results will provide important data for the future COVID 19 vaccine strategy. A biobank will also be set up to evaluate the protection conferred by one or other of these vaccines as booster in the event of the emergence of new variants in the future. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-03-01 |
| 434 | Immunogenicity and Safety of IndoVac® As A Heterologous Booster Dose Against COVID-19 in Children 12-17 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate immune response and safety of SARS-CoV-2 subunit protein recombinant vaccine (IndoVac) as a heterologous booster dose in healthy children 12-17 years of age. Participants who had received complete primary doses of inactivated (Sinovac®) COVID-19 Vaccine will be given IndoVac as a booster dose. |
EDDY FADLYANA; | 2023-03-01 |
| 435 | CONFIDENCE: A Pilot Randomized Control Trial With Waitlist Condition to Test A Multicomponent Clinic-based Intervention to Promote COVID-19 Vaccine Intention and Uptake Among Diverse Youth and Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to refine and test CONFIDENCE, a multi-component clinic-based intervention in pediatric or family practice clinical settings. Using a randomized control trial design, the investigators will assess preliminary effectiveness of the intervention to increase COVID-19 vaccine intention among parents of under-vaccinated children ages 5 to 17. Participating clinics will receive a brief intervention consisting of: (1) webinar training focused on communication with vaccine-hesitant parents, (2) parent-facing educational materials about COVID-19 vaccination, (3) support to create a personalized, … |
STEPHENIE LEMON; | 2023-03-01 |
| 436 | Interrogative Approaches Identify Causes of Physical Impairment in Those Affected By Post COVID-19 Morbidity (Long COVID) – An International Multicenter Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The value of clinical cardiopulmonary exercise testing (CPET) within healthcare settings has been established in the last decade. CPET methods remain highly relevant in the COVID-19 endemic phase and should be used to assess those recovering from COVID-19 (SARS-CoV-2) infection. This diagnostic tool could play an integral role in disease prognostication and evaluate the integrative response to incremental exercise. Date from such assessments can enable practitioners to characterise cardio-respiratory fitness and identify reasons for physical impairment or abnormal cardio-respiratory function. More than 50% of patients admitted to hospital will experience cardiorespiratory issues and significant morbidity during their recovery and will require significant rehabilitative support. In this context, measurements obtained from an assessment of cardio-respiratory responses to physiological stress could provide insight regarding the integrity of the pulmonary-vascular interface and characterisation of any impairment or abnormal cardio-respiratory function. Current approaches to rehabilitation are being developed on existing knowledge from Severe Acute Respiratory Syndrome (SARS) and Acute Respiratory Distress Syndrome (ARDS) related illness. These provide important insight but do not provide insight into the novel challenges provided by COVID-19. |
CEMAL OZEMAK; | 2023-03-01 |
| 437 | Clinical, Laboratory, and Radiological Characteristics of Urinary Tract Infections in Infants With COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Urinary tract infections (UTIs) in infants and young children are one of the most common bacterial infections, usually febrile illness without source, frequently due to Enterobacteriaceae, mainly Escherichia coli. Multidrug-resistant organisms including extended-spectrum beta-lactamase (ESBL) producing bacteria are becoming more prevalent. Due to the risk factors of ESBL-producing organisms in community-acquired (CA)-UTIs in infants in QATAR and Arab countries are still not studied because of the limited therapeutic options. hence, the importance of this study is to get knowledge about how to decrease the rapidly increasing in ESBL- producing bacteria, in infants, and to use antibiotics in a suitable guideline.so, … |
MAHMOUD ALHANDI OMAR HELAL; | 2023-03-01 |
| 438 | REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session. |
PAUL WISCHMEYER; | 2023-03-01 |
| 439 | A Study of Positive Emotions With Long COVID (Post-Acute Sequelae of SARS CoV-2 Infection) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is testing a new brief mindfulness practice for people suffering from long COVID-19 symptoms. People suffering from long COVID are particularly vulnerable to negative emotions, as they must also cope with the long-term uncertainty of physical and psychological stress beyond the acute infection. The goal of the study is to measure the ability of a brief mindfulness practice to promote a sense of well-being in people suffering from long COVID. |
JAVIER E LOPEZ; | 2023-03-01 |
| 440 | Developing An Effective Intervention to Address Post-COVID-19 Balance Disorders, Weakness and Muscle Fatigue in Individuals Aged 65+ PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The long-term consequences and sequelae of COVID-19 are still unclear; however, a vast number of elderly individuals have reported prolonged general weakness and muscular fatigue, leading to significant functional decline, increased risk of falls, morbidity and mortality rates. However, effective exercise intervention for such post-COVID-19 patients is still not well documented. Previous studies indicate that, in general, resistance training (RT) appears to be the most effective, safe method for combating the loss of muscle mass, strength and functional capacity. The aim of investigators study is to develop/adopt an effective intervention specifically for elderly (65+) people with post COVID-19 condition, … |
JÓZEF PIŁSUDSKI UNIVERSITY OF PHYSICAL EDUCATION | 2023-03-01 |
| 441 | The Efficacy and Safety of Acupuncture for Post COVID-19 Fatigue: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to access the efficacy and safety of acupuncture for post COVID-19 fatigue. |
YUANJIE SUN; | 2023-03-01 |
| 442 | Efficacy and Safety of Jaktinib in Patients With COVID-19 Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This was a randomized, double-blind, placebo-controlled parallel study. |
JIANYA ZHOU; | 2023-03-01 |
| 443 | A Phase 1, Open-Label, Adjuvant Dose-Escalation, Randomized Study to Evaluate The Safety and Immunogenicity of VBI-2901e, A Trivalent Coronavirus Vaccine Candidate Adjuvanted With Aluminum Phosphate and E6020 in Healthy Adults Previously Vaccinated With Licensed COVID-19 Vaccines PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: VBI-2901e is an investigational vaccine candidate that uses enveloped virus-like particles (eVLPs) to express the spike proteins of three coronaviruses: SARS-CoV-2 (the virus that causes COVID-19 disease), SARS-CoV-1 and MERS-CoV. The trivalent vaccine candidate is designed to induce neutralizing antibody and cell-mediated immune responses against the spike protein of the original strain of SARS-CoV-2 coronavirus, variants and subvariants of SARS-CoV-2 (such as Beta, … |
WILLIAM CAMERON; | 2023-03-01 |
| 444 | Beta Endorphins,Interleukin 1 and Interleukin 38 in Covid Patients Associated With Neuropsychological Manifestations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Measurement of Beta endorphins,interleukin 1 and interleukin 38 in covid patients associated with neuropsychological manifestations. |
SOMAYA REDWAN YOUNES; | 2023-03-01 |
| 445 | An Open Safety Study and Description of The Parameters of The Therapeutic Efficacy of The Drug for Early Etiotropic Therapy for Coronavirus Infection Caused By The SARS-CoV-2 Virus, With A Single Application in Patients With Confirmed COVID-19 Diagnosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Open prospective non-comparative study of safety and tolerability of the drug (GamCoviMab) with the description of the parameters of the therapeutic efficacy in patients with confirmed COVID-19 diagnosis. |
GAMALEYA RESEARCH INSTITUTE OF EPIDEMIOLOGY AND MICROBIOLOGY HEALTH MINISTRY OF THE RUSSIAN FEDERATION | 2023-03-01 |
| 446 | The Use of Photobiomodulation in The Treatment of Oral Complaints of Long COVID-19. A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronavirus (COVID-19) is a newly emerging zoonotic agent that emerged in December 2019 in China (2019-nCoV) as a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV -2). Long COVID-19, or Post-Covid Syndrome or Long-term COVID-19, is a post-viral syndrome that persists after the acute infection has resolved. The most frequent symptoms of Lonf-term COVID are fatigue and dyspnea. But two classes of symptoms have been received scientific attention: the musculoskeletal pain and oral complaints related to Long COVID, mainly xerostomia and burning mouth. Photobiomodulation (PBM) therapy is often used for oral diseases and presents itself as a non-invasive, low-cost, … |
REBECA BOLTES CECATTO; | 2023-03-01 |
| 447 | A Single-arm, Open-label Phase I Clinical Study to Evaluate The Safety, Tolerability and Immunogenicity of Recombinant COVID-19 Vaccine (Adenovirus Vector) for Inhalation in People 21 to 65 Years Old (Previously Primed With Authorized Vaccines) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this trial, a single-arm, open-label study design will be used to evaluate the safety and tolerability after vaccination with escalating doses of the investigational vaccine (Recombinant COVID-19 Vaccine (chimpanzee adenovirus vector) for Inhalation, RCVi) at low, medium, and high doses in healthy adults (previously primed with authorized vaccines). |
PAUL TAMBYAH; | 2023-03-01 |
| 448 | Phase II/III Double-blind, Randomized Clinical Trial With Active Vaccine Control to Evaluate The Safety, Immunogenicity, and Consistency of The Lots of Booster Dose of COVID-19 (Recombinant, Inactivated) Vaccine in Adults in Brazil PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: NDV-HXP-S is an inactivated COVID-19 vectored-vaccine virus using the Newcastle Disease Virus as basis and expressing Spike (S) protein from SARS-CoV-2 stabilized in pre-fusion form with Hexapro technology. This vaccine was successfully tested in non-clinical and clinical studies with a good safety profile and eliciting neutralizing antibodies against SARS-CoV-2. Clinical testing is conducted by an international consortium including three different manufacturers. Butantan, in Brazil, is one of them. |
BUTANTAN INSTITUTE | 2023-02-28 |
| 449 | A Randomised Controlled Trial to Assess The Immunogenicity, Safety & Reactogenicity of Standard Dose Versus Fractional Doses of COVID-19 Vaccines (Pfizer-BioNTech, AstraZeneca or Moderna) Given As A Booster Dose After Priming With Coronavac or AstraZeneca in Healthy Adults in Indonesia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomised controlled clinical trial to determine the reactogenicity and immunogenicity of booster doses of SARS-CoV-2 vaccines (Pfizer-BioNTech, AstraZeneca or Moderna) in adults who have previously received either AstraZeneca or Coronavac as their primary doses. Both fractional and standard doses of Pfizer-BioNTech, AstraZeneca and Moderna will be tested. |
EDDY FADLYANA; | 2023-02-28 |
| 450 | A Study of Activity Leader to Forest Therapy Campaign in Different Environments Targets on The Participants Which Had Been Infected By SARS-COV-2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the impact of self-guided forest healing activities and guided forest healing activities on the reduction of psychological stress inindividuals diagnosed with the new coronavirus. The main questions aim to answer are: 1. Effectiveness of Forest Healing Activities on Emotional Well-being: Researchers will compare the emotional improvement effects between self-guided and guided forest healing activities to determine their effectiveness. 2. Comparison of Healing Effects in Different Locations: Researchers will compare the effects of forest healing activities conducted in two similar environments, the Taipei Botanical Garden and the Chiayi Arboretum, … |
CHUNG-HUA HSU; | 2023-02-27 |
| 451 | Post COVID-19 Complications in Children Attending Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Is to record post COVID-19 complications in patients below 18 years old in assiut University children hospital |
GEHAD GAMAL ALI; | 2023-02-24 |
| 452 | A Prospective Observational Study of The Impact of A Recent Past COVID-19 Infection on The Live Birth Rates of Frozen Embryo Transfer Cycles PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective observational study. In this study, we aim to investigate the effect of a recent past Covid-19 infection on the live birth rate in the frozen embryo transfer cycles |
SHANGHAI JI AI GENETICS & IVF INSTITUTE | 2023-02-23 |
| 453 | A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase IIa/IIb Study to Evaluate The Safety, Tolerability, and Efficacy of NP-101 in Treating High-Risk Participants Who Have Tested Positive for Novel Coronavirus 2019 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the safety, tolerability, and efficacy of NP-101 in treating high-risk participants who have tested positive for Covid-19. The main question[s] it aims to answer are: – To evaluate the safety of NP-101, as well as establish the maximum tolerated dose in high risk Covid-19 positive patients. Participants will [describe the main tasks participants will be asked to do, treatments they’ll be given and use bullets if it is more than 2 items]. If there is a comparison group: Researchers will compare [insert groups] to see if [insert effects]. |
NOVATEK PHARMACEUTICALS | 2023-02-22 |
| 454 | Study on The Antibody Level Against SARS-CoV-2 in Dazhu County in 2023 PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: About 15,000 to 25,000 subjects will be screened. Their information will be collected, venous blood will be sampled, their serum antibody levels will be detected, and the incidence of COVID-19 wil be followed up. |
BO ZHOU; | 2023-02-21 |
| 455 | Effect of Post-traumatic Stress Disorder (PTSD) of Surgeons and Anesthesiologists on Postoperative Complications of Surgical Patients Under The Background of The COVID-19 Pandemic PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this prospective cohort study is to explore the association between the development of post-traumatic stress disorder (PTSD) in surgeons and anesthesiologists and postoperative prognosis in surgical patients they care for during the COVID-19 pandemic. There are 2 cohorts included in this study. The first cohort consists of registered surgeons and anesthesiologists in the study center. The development of PTSD will be evaluated with a series of questionnaires and scales. This cohort defines exposure (with PTSD). The second cohort consists of surgical patients managed by the surgeons and anesthesiologists in the first cohort. The postoperative outcome of these patients will be evaluated thus to explore the association between PTSD in physicians and adverse patient outcomes. The second cohort defines the outcomes( response). |
CHONG LEI; | 2023-02-21 |
| 456 | Natural History, Disease Progression, and Long-Term Neurologic Sequelae of Ebola Virus Disease Survivors in PREVAIL III PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Ebola virus disease (EVD) is a viral fever that can cause internal bleeding. The death rate from EVD is very high. In a 2014 outbreak in West Africa, 28,000 were affected and 11,000 died. EVD may also affect the brain and nervous system, … |
BRIDGETTE J BILLIOUX; | 2023-02-21 |
| 457 | A Phase I/II Partially Randomized, Active-controlled Observer-blind, Dose-selection, Safety and Immunogenicity Study of GLB-COV2-043, An MRNA Vaccine Candidate Against SARS-CoV-2, Administered As A Single-vaccination Booster to Previously Vaccinated Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The scope of this Phase I/II study is to determine whether GLB-COV2-043 is a promising booster vaccine candidate component for adult participants who have received the 2-dose priming course of the mRNA BNT162b2 vaccine against COVID-19, or the 2-dose priming course and a third BNT162b2 injection (i.e., as a booster), and, if so, to select the booster dose for further evaluation and potential development. |
GREENLIGHT BIOSCIENCES | 2023-02-21 |
| 458 | Safety and Immunogenicity of A Dose of The Sanofi-GSK Monovalent (B.1.351) CoV2 PreS DTM-AS03 COVID-19 Vaccine in Kidney Transplant Recipients With A Persistently Low SARS CoV-2 Antibody Titer (COVID19-TB-04) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An open label, non-randomized pilot study in kidney transplant recipients who received a completed primary series and bivalent booster of mRNA based COVID-19 vaccine and have =\<2500 U/mL SARS-CoV-2 S antibody concentration using the Roche Elecsys(R) anti-RBD assay. Up to 80 participants will be enrolled in this study. Eligible participants will receive a dose of the Sanofi-GSK monovalent (B.1.351) CoV2 preS dTM-AS03 COVID-19 vaccine candidate.. The primary objective is to determine whether a booster dose of the Sanofi-GSK monovalent (B.1.351) CoV2 preS dTM-AS03 COVID-19 vaccine will elicit an increased SARS-CoV-2 antibody response in participants who have failed to maintain an antibody titer \>2500 U/mL (using the Roche Elecsys(R) anti-RBD assay) to 2 or more doses of mRNA based COVID-19 vaccine |
CHRISTINE DURAND; | 2023-02-20 |
| 459 | Ketogenic Intervention in Depression PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to examine whether a well-formulated ketogenic diet (KD) can be implemented into a university counseling treatment program for major depression and to test whether such a program has any benefit on mental and metabolic health. |
OHIO STATE UNIVERSITY | 2023-02-20 |
| 460 | A Multi-center, Randomized, Double-blind, Placebo-controlled Phase Ⅲb Clinical Trial to Evaluate The Efficacy, Immunogenicity and Safety of COVID-19 Vaccine (Vero Cell), Inactivated Booster Dose in Adults Aged 18 Years and Above Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, case-driven, randomized, double-blinded, and placebo-controlled Phase Ⅲb clinical trial of COVID-19 Vaccine manufactured by Sinovac Research & Development Co., Ltd.The purpose of this study is to evaluate the efficacy of the booster dose after two doses of CoronaVac® against RT-PCR confirmed symptomatic COVID-19 cases in participants aged 18 years and above. |
JAVED KHAN; | 2023-02-20 |
| 461 | Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African Americans Study (GENEFORECAST): Prospective COVID-19 Natural History Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The COVID-19 pandemic infected and killed African Americans at higher rates than other Americans. Researchers want to understand why. Objective: This natural history study will look at how genetic, environmental, … |
LAURA M. KOEHLY; | 2023-02-18 |
| 462 | Association of Symptoms, Clinical and Biochemical Characteristics in Post COVID-19 Syndrome: A Case-control Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to describe the symptoms that persist for more than 12 weeks after the acute episode in participants who had COVID-19, and compare the functional, socioeconomic and occupational effects with a post-COVID-19 control group without persistent symptoms after the COVID-19 acute event. The main questions it aims to answer are: – What are the characteristics of symptoms that persist for more than 12 weeks in participants who have had COVID19 in the last year? – What are the health-related quality of life and psychosocial effects in participants with persistent symptoms of COVID-19, … |
LAURA ANTONIETTI; | 2023-02-16 |
| 463 | Profile of COVID-19 Patients Related to Fatigue PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: More than half of recovered COVID-19 patients experience fatigue. Studies are needed to define the profile of these patients. The objective of this study is to evaluate the profile of surviving patients of COVID-19 in relation to fatigue. |
IRENE TORRES SÁNCHEZ; | 2023-02-15 |
| 464 | Bright Light Therapy for Post-COVID-19 Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized placebo-controlled trial to examine the efficacy of two-week bright light therapy for patients with post-COVID-19 fatigue. |
JOEY WY CHAN; | 2023-02-15 |
| 465 | Clinical Study of The Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19 Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to evaluate the safety and effectiveness of umbilical cord mesenchymal stem cell (UCMSC)-derived extracellular vesicle nebulization inhalation therapy for the treatment of chronic cough after COVID-19 infection. The main objective is to assess whether UCMSC-derived exosome nebulization inhalation therapy alleviates chronic cough after COVID-19. Participants will be asked to complete a questionnaire to help researchers evaluate their cough severity and to record their scores before nebulization inhalation of UCMSC-derived exosomes. Participants will receive either continuous nebulized inhalation of UCMSC-derived exosomes for 5 days, twice daily, … |
JIHUI DU; | 2023-02-15 |
| 466 | A Prospective Cohort Study Investigating The Success Rate of Fit Testing Following The Use of A 3D Printed Respirator Adapter From A Facial 3D Scan PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Healthcare workers PPE (personal protective equipment) when interacting with patients either infected or, potentially carrying SARS-CoV-2. One of the major routes of transmission is via droplet spread through oral and nasal mucosa therefore respiratory protective equipment (RPE) is an important part of PPE. There are concerns in dentistry that droplet spread can be increased during aerosol-generating procedures (AGP). This poses an increased risk to dentists and allied professionals in a clinical setting. Fit testing is needed to ensure a mask forms a facial seal around the mouth and nose. Using a respirator mask without fit testing can reduce its effectiveness from between 6-88% with an optimal facial seal being more critical than the filtering performance. Commercial respirator masks are mass-produced for ‘ standard’ faces, and often fail to provide a good fit for users thereby compromising the intended respirator filtering capability. Given the high level of fit test failures, without the provision of improved fits of masks, patient care will be highly curtailed for frontline staff at risk of SARS-CoV-2. Therefore, a reusable bespoke 3D printed mask adapter used with a soft FFP3 disposable mask provides an economical solution to address the passing of fit testing. Barts Health NHS Trust staff members who have previously failed the fit test to the first line FFP3 disposable respirator will be invited to enrol in this study. Barts/QMUL scan App will be used to capture the facial scan of the subjects using a research allocated smartphone. Participants will be asked to be clean-shaven without any facial jewellery which could hinder the scan data. The App automatically generates a customized 3D print file (.stl) which will be sent for 3D printing. The mask adapter will be fitted over the first-line FFP3 respirator once it is properly worn and checked as per the procedure. |
BARTS & THE LONDON NHS TRUST | 2023-02-15 |
| 467 | Study and Analysis on The Characteristics of Intestinal Microorganisms and Serum Metabolites in Patients With Acute Pancreatitis Complicated With COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study was to explore the complex relationship between changes in the intestinal microbiome and serum metabolites in patients with novel coronavirus infection and acute pancreatitis. The main questions it aims to answer are: Question 1: The changes of intestinal microbiota and serum metabolites in patients with novel coronavirus infection and acute pancreatitis. Question 2: The relationship between the changes in the intestinal microbiome and serum metabolites. Participants will be recruited according to certain criteria. The investigators plan to recruit 4 groups of 30 volunteers, … |
YUANSONG SUN; | 2023-02-15 |
| 468 | Randomized, This Study Aims To Investigate The Effect of High Frequency Chest Wall Oscillation in Hospitalized Covid-19 Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: INFLUENCE OF HIGH FREQUENCY CHEST WALL OSCILLATION IN HOSPITALIZED PATIENTS WITH COVID-19 The purpose of this Interventional study is to investigate the effect of high frequency chest wall oscillation in hospitalized COVID-19 patients on: 1. Inflammatory markers: Netrophil to lymphocyte ratio and CRP 2. Hemodynamic parameters (Arterial Blood Gases, Heart Rate variability, Respiratory Rate, O2 Saturation). 3. Dyspnea, time needed for oxygen weaning, Mortality Rate and Hospital stay period. Hypotheses : This Interventional study will test the following Null hypothesis: – HFCWO will not have an effect in hospitalized COVID-19 patients regarding Arterial Blood Gases, CRP, Dyspnea, Heart Rate variability, … |
HADEEL IBRAHIM ELSAYED ELHANNONY; | 2023-02-15 |
| 469 | MGC Health COVID-19 & Flu A+B Home Multi Test Usability Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the usability of the MGC Health COVID-19 & Flu A+B Home Multi Test in home use. |
MEDICAL GROUP CARE | 2023-02-14 |
| 470 | Inhaled NO ReDuce PostoperatIve PulmoNAry ComplicATions in PatiEnts With Recent COVID-19 Infection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the effect of perioperative inhalation of NO on reducing the incidence of postoperative pulmonary complications in patients with recent COVID-19 infection, and to evaluate whether inhaled NO can improve the prognosis of patients. The investigators will enroll 660 surgical patients who was infected with SARS-CoV-2 within 42days (7 weeks ) prior to planed surgery under general anesthesia. Patients will be randomized to receive either inhaled nitric oxide (per protocol) or a placebo. Perioperative standards of care will be the institution’s own protocols (such as ventilation strategies and use and dose of anesthetics, … |
CHONG LEI; | 2023-02-10 |
| 471 | The Difference Between Non-invasive High-frequency Oscillatory Ventilation and Non-invasive Continuous Airway Pressure Ventilation in COVID-19 With Acute Hypoxemia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: High frequency oscillatory ventilation (HFOV), as an ideal lung protection ventilation method, has been gradually applied to neonatal intensive care treatment, and is currently recommended as a rescue method for neonatal acute respiratory distress syndrome (ARDS) after failure of conventional mechanical ventilation. Although its ability to improve oxygenation and enhance carbon dioxide (CO2) clearance has been repeatedly demonstrated in laboratory studies, its impact on the clinical results of these patients is still uncertain. Noninvasive high-frequency oscillatory ventilation (nHFOV) combines the advantages of HFOV and non-invasive ventilation, … |
JIANYI NIU; | 2023-02-10 |
| 472 | Post COVID REspiratory Mechanisms and The Efficacy of A Breathing Exercise Intervention for DYsregulated Breathing (REMEDY): COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A pilot Study To investigate the efficacy of a breathing intervention for improving persistent breathlessness due to dysregulated breathing following COVID-19 when compared to usual care. |
CHARLOTTE BOLTON; | 2023-02-10 |
| 473 | A Randomized, Observer-Blind, Dose Escalation, Placebo-Controlled, Phase 1 Clinical Trial to Study The Safety and Immunogenicity of A COVAC-1 Booster Dose in Generally Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: VIDO has developed a vaccine called COVAC-1. The COVAC-1 study vaccine contains a portion of the SARS-CoV-2 spike protein, called S1. The spike protein is the part of the virus that is responsible for attaching to the surface of host cells. COVAC-1 contains a TriAdj adjuvant. An adjuvant is a compound that is added to a vaccine to help the vaccine produce a better immune response. The vaccine is expected to stimulate the body to make antibodies against the S1 protein. The antibodies will recognize the viral spike protein if the body is exposed to the virus and prevent COVID-19 illness. In animal studies, the immune response generated by the COVAC-1 vaccine was able to protect the vaccinated animals against a severe SARS-CoV-2 infection. The COVAC-005 Study is a Phase I, multi-centre trial of a SARS-CoV-2 vaccine booster. This is a randomized, observer-blinded, and placebo-controlled study to assess the safety and immunogenicity of COVAC-1 booster dose administered once in generally healthy adults 18-65 years of age who have received a minimum of 2 doses of an authorized COVID-19 vaccine at least 4 months prior to Day 0. The study will follow a dose-escalation design to test the safety and immunogenicity of three dosage levels (10, 25 and 50 µg). In each dose escalation group participants will be randomized in a 3:1 ratio, to receive either the investigational product or a placebo, respectively. Stratification will be according to the Investigational product dose received. Sub-analysis will be completed in two age groups, 18-54 and 55-65 years. Study participants will be initially randomized to the lowest dose of 10 µg or placebo. After approval by the Sponsor and based on the recommendations from the DSMB following the Day 7 safety analysis, new study participants will be allowed to be randomized in the higher dose escalation group of 25 µg. Approval will also be sought from the Sponsor, based upon the DSMB recommendation, to proceed with the higher dose of 50 µg. Within each dose escalation group of 16 participants (12 active vaccine recipients, and 4 placebo recipients) it is proposed to randomize a first cohort of 4 participants, including at least 3 active vaccine recipients, and pending no holding rule is met after 48 hours, as determined by the post-injection phone call, the remaining 12 participants within that dose escalation group will be randomized. |
VOLKER GERDTS; | 2023-02-10 |
| 474 | A Prospective Multicenter Study Conducted to Evaluate The Performance of The LumiraDX SARS-CoV-2 Ag Ultra and LumiraDX SARS-CoV-2 & Flu A/B Tests At Point of Care Sites PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective multicenter study conducted to evaluate the performance of the LumiraDx SARS-CoV-2 Ag Ultra test in detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and LumiraDx SARS-CoV-2 \& Flu A/B test in differential detection of SARS-CoV-2, Influenza A (Flu A) and Influenza B (Flu B) at point of care sites. Subjects presenting with symptoms suggestive of coronavirus disease 2019 (COVID-19) and/or Influenza at the time of the study visit will be enrolled and asked to donate swab sample(s) for testing in the device(s) under evaluation. |
LUMIRADX UK | 2023-02-09 |
| 475 | Identifying and Addressing Critical Social, Ethical, and Behavioral Factors Associated With COVID-19 Testing and Vaccination Among Spanish Speakers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Latinx communities are disproportionately affected by the COVID-19 pandemic, with Spanish-speaking Latinx communities carrying even heavier burdens of infection, hospitalization, and mortality. Major barriers to COVID-19 testing and vaccination exist, and a profound need remains to understand and address the social, ethical, and behavioral implications (SEBI) of COVID-19 testing and vaccination within Latinx communities. Our community-academic partnership proposes a rigorous mixed-methods, community-based participatory research study to better understand the SEBI of COVID-19 testing and vaccination and to refine and test a novel and culturally congruent intervention that integrates two evidenced-based strategies – peer navigation and mHealth – … |
SCOTT D RHODES; | 2023-02-09 |
| 476 | Evaluation of KGR Prescriptions in Suppressing COVID-19 Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: These studies offer valuable insights into the potential development of KGR as a novel herbal-based preventive and therapeutic strategy against COVID-19. |
SHENG-TENG HUANG; | 2023-02-09 |
| 477 | Computerized Cognitive Remediation of Long COVID Symptoms in Older Adults PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research is being done to collect preliminary data on the potential of computerized brain-training exercises for treating Long COVID symptoms in older adults. The investigators hypothesize that computerized brain-training will be an acceptable and feasible intervention for treating Long COVID symptoms in older adults. The investigators also expect to provide initial evidence that computerized brain-training has potential for improving thinking, mood, and other aspects of everyday functioning in older adults with Long COVID. |
CUTTER LINDBERGH; | 2023-02-08 |
| 478 | Effectiveness of Modified Diaphragmatic Training for Improving GERD-Q Score, Diaphragmatic Excursion, Maximum Inspiratory Pressure and Lung Function in Adults With Gastroesophageal Reflux Disease After Covid-19 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study titled Effectiveness of Modified Diaphragmatic Training for Improving GERD-Q Score, Diaphragmatic Excursion, Maximum Inspiratory Pressure and Lung Function in Adults With Gastroesophageal Reflux Disease After Covid-19: a Single-blinded Randomized Control Trial is a clinical trial that aimed to investigate the effectiveness of 4 weeks modified diaphragmatic training (MDT) compare with standard diaphragmatic training for improving GERD-Q score, diaphragmatic excursion, maximum inspiratory pressure, and lung function in adults with gastroesophageal reflux disease (GERD) after COVID-19. The trial was single-blinded and randomized, … |
SITI CHANDRA WIDJANANTIE; | 2023-02-08 |
| 479 | Levels of Physical Activity After SARS-CoV-2 Infection in Greek Adults: The Role of Pre-illness Vaccination and The Number of Reinfections PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Coronavirus infection has an impact on several aspects of everyday life including the levels of Physical Activity (PA). Investigators wish to (1) detect changes on PA levels in recovered SARS-CoV-2 (COVID-19) adults compared to the pre-infection levels and (2) identify a potential relationship between changes of PA levels and pre-illness vaccination profile along with individual’s number of infection/reinfections. It is assumed that the impact of COVID-19 infection on PA would be more pronounced in cases of repeated infections and/or in the unvaccinated compared to the vaccinated individuals against COVID-19. |
EMMANOUIL D. ZACHARAKIS; | 2023-02-07 |
| 480 | Phase 2/3 Study to Evaluate Safety, Tolerability and Immunogenicity of A Recombinant Protein-based Vaccine Against SARS-CoV-2, in A Population of Adult Volunteers Previously Vaccinated Against SARS-CoV-2 Virus PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goals of this clinical trial are: 1. Phase 2: to test a gamma adapted recombinant vaccine against SARS-CoV-2 in healthy adult volunteers, previously vaccinated against the SARS-CoV-2 virus. 2. Phase 3 (first volunteer enrollement on March 25, 2023): to test a recombinant vaccine against SARS-CoV-2 comparing three different versions (Gamma Variant RBD-based ARVAC-CG vaccine, Omicron Variant RBD-based ARVAC-CG vaccine, Bivariant Gamma/Omicron RBD-based ARVAC-CG vaccine), … |
PABLO BONVEHÍ; | 2023-02-06 |
| 481 | A Randomised Controlled Trial to Assess The Immunogenicity, Safety and Reactogenicity of A Bivalent MRNA Moderna COVID-19 Vaccine or A Protein-based Novavax COVID-19 Vaccine Given As A Fourth Dose in Healthy Adults in Australia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a double-blinded, randomised study to determine the safety, reactogenicity, and immunogenicity of a bivalent mRNA Moderna COVID-19 vaccine or a protein-based Novavax COVID-19 vaccine given as a fourth dose in healthy adults in Australia. |
KIM MULHOLLAND; | 2023-02-06 |
| 482 | Prospective, Multi-Center, Non-Randomized Study to Evaluate OTC At Home SARS-CoV-2 Molecular Diagnostic Test PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the a molecular, OTC/At-Home COVID-19 Test in individuals presenting at a medical facility. In eligible subjects, nasal samples will be collected for use with the at-home molecular COVID-19 Test, which will be compared to the Zymo® rRT-PCR test results obtained via samples specified by the sponsor (e.g., AN [anterior nares] swab) to determine accuracy of the at-home/OTC molecular COVID-19 Test in detecting COVID-19 in participants. |
3EO HEALTH | 2023-02-06 |
| 483 | Early Return of COVID-19 Patients to Home on Oxygen: Evaluation of A New Strategy Based on The City/Hospital Link PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The René Dubos Hospital in Pontoise has set up a home discharge system for oxygen-requiring patients in collaboration with PRADO, a health insurance organization, or private providers. This organization coordinates the care to be implemented at home based on the city/hospital link. The coordinator of this organization was also in charge of scheduling a follow-up consultation between 7 and 14 days after hospital discharge. The aim of this study is to evaluate this new organization, both in terms of its impact on patient outcomes (survival and re-hospitalization rates) and on patients’ experiences and satisfaction with their care. |
CELESTE LAMBERT; | 2023-02-06 |
| 484 | A Randomized, Controlled, Partial-Blind, Crossover Study to Characterize The Nicotine Pharmacokinetics and Subjective Effects of Five Oral Nicotine Products Relative to Moist Smokeless Tobacco (MST) in Adult MST Users PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study was to obtain information on nicotine exposure following the use of five oral tobacco-derived nicotine (OTDN) products relative to subjects’ own brand moist smokeless tobacco (OBMST) product in adult moist smokeless tobacco (MST) users, as well as to characterize subjective effects under controlled use conditions. Male and female adult MST users between the ages of 22 to 65 years were recruited. The total duration of participation for each subject was approximately 34 days including screening and a 6-day in-clinic study confinement period. |
ALTRIA CLIENT SERVICES | 2023-02-06 |
| 485 | Face Masks to Reduce Symptomatic and Asymptomatic SARS-CoV-2 Infections in Bangladesh PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of the village-level intervention is to assess whether mask-wearing reduces community-level asymptomatic and symptomatic SARS-CoV-2 infections, assessed via PCR testing. The study also examines if community-based activation through values or individual activation through information results in higher mask-wearing. |
YALE UNIVERSITY | 2023-02-04 |
| 486 | A Phase III Study to Evaluate The Safety and Immunogenicity of PTX-COVID19-B Administered As Booster Vaccination in Previously Vaccinated Adults Aged 18 Years and Older PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this clinical trial is to Evaluate the Safety and Immunogenicity of PTX-COVID19-B Administered as Booster Vaccination in Previously Vaccinated Adults Aged 18 Years and Older. This study is seeking participants who are: Adult males and females 18 years of age or older; … |
EVEREST MEDICINES SINGAPORE PTE | 2023-02-03 |
| 487 | A Phase III, Randomized, Observer-Blind Study to Evaluate The Safety and Superiority in Immunogenicity of PTX-COVID19-B Administered As Booster Vaccination Compared to Vaxzevria® in Adults Aged 18 Years and Older Who Were Previously Vaccinated With Vaxzevria® PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase III, Randomized, Observer-Blind Study to Evaluate the Safety and Superiority in Immunogenicity of PTX-COVID19-B Administered as Booster Vaccination Compared to Vaxzevria® in Adults Aged 18 Years and Older Who Were Previously Vaccinated with Vaxzevria®. This study will be a competitive enrollment process in all participating countries. Once the target number of subjects is reached, the enrollment in all participating countries in the particular phase will be stopped. |
EVEREST MEDICINES SINGAPORE PTE | 2023-02-03 |
| 488 | Evaluation of The Impact of A Digital Self-testing Strategy in Individuals With Suspected COVID-19 Infection in South Africa on Time to Action Plans, Linkage to Care, Detection of New Infections: A Randomized Controlled Superiority Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: As the world opens up to rapidly increasing vaccination coverage and newer variants, there is an even greater need for timely access to at-home COVID-19 testing, or self-testing based out of kiosks, offices, or private spaces. Data on digital strategies that complement self-testing are sparse. Using a superiority randomized controlled trial design (open-label, single-blinded), the investigators will aim to evaluate the impact of a digital self-testing strategy offered out of kiosks/private spaces on the turnaround time to test results, the proportion of participants initiated on action plans, … |
NITIKA PAI; | 2023-02-02 |
| 489 | A Global Multi-center, Randomized, Blinded, Placebo-controlled Phase 3 Clinical Study to Evaluate The Efficacy, Safety and Immunogenicity of SARS-CoV-2 MRNA Vaccine for The Prevention of COVID-19 in Participants Aged 18 Years and Older PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: A Global Multi-center, Randomized, Blinded, Placebo-controlled Phase 3 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of SARS-CoV-2 mRNA Vaccine (LVRNA009) for the Prevention of COVID-19 in Participants Aged 18 Years and Older |
AIM VACCINE | 2023-02-01 |
| 490 | Long COVID Symptoms in SARS-CoV-2-positive Children Aged 6-18 Years in China: A Consequential Observation Study PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about in children aged 6-18 years, after the acute phase of SARS-CoV-2 infection, the COVID symptoms or Long COVID symptoms to impact their daily activities. We aimed to investigate the prevalence of long-lasting symptoms, the duration and intensity of symptoms, quality of life, number of sick days or absences from school, and psychological and social outcomes. The participants will be asked to fill in Long COVID symptom burden questionnaires who had been infected with SARS-CoV-2 as self-reported PRC test or antigen test positive. |
TIM SHI; | 2023-02-01 |
| 491 | IVD_ Starfish_Clinical Performance Study Protocol for US – Project STARFISH – PRJ0002679 PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a non-interventional study to perform the clinical performance evaluation of the Starfish Test using prospectively collected matched nasopharyngeal and nasal swab samples from the same donor. In order to meet the minimum sample requirements, and to demonstrate performance on a range of viral strains, the prospective collection may be supplemented with banked remnant nasal and/or nasopharyngeal samples. |
THERMO FISHER SCIENTIFIC | 2023-02-01 |
| 492 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of GS-5245 for The Treatment of COVID-19 in Nonhospitalized Participants PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to test if GS-5245 is safe and effective for the treatment of COVID-19 in participants who have a standard risk of developing severe illness. The study will also measure how much GS-5245 gets into the blood and how long it takes for the body to get rid of it. |
GILEAD SCIENCES | 2023-02-01 |
| 493 | Evaluation of A COVID-19 Quick Start Test and Treat Model in Africa PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Duke University and the Clinton Health Access Initiative (CHAI), in partnership with the Ministries of Health (MoH) of Ghana, Malawi, Rwanda, Zambia, and Zimbabwe, aim to assess the implementation and impact of COVID-19 test -and -treat (T&T) demonstration programs |
KRISHNA UDAYAKUMAR; | 2023-02-01 |
| 494 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Study Evaluating The Efficacy and Safety of STI-1558 in Adult Subjects With Mild or Moderate (COVID-19) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, randomized, double-blind, placebo-controlled phase III clinical study to evaluate the efficacy and safety of STI-1558 in adult subjects with mild/moderate COVID-19. One thousand and two hundred adult subjects with mild/moderate COVID-19 (including subjects with high risk factors for progression into severe cases) are planned to be enrolled and randomized in a ratio of 1:1 into the test group or the placebo group (600 in the test group and 600 in the placebo group). |
ZHEJIANG ACEA PHARMACEUTICAL | 2023-02-01 |
| 495 | The Risk of SARS-CoV-2 Infection and Severity of COVID-19 Among Healthcare Workers With or Without Previous COVID-19 Vaccines PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: At present, COVID-19 vaccine is considered as the safest, economic and effective measure to prevent and control COVID-19. Adaptive immunity, including humoral immunity and cellular immunity, plays a role in anti-viral responses. Cellular immunity includes virus specific B cells and T cells, which can provide long-term memory immunity. For acute viral infection, neutralizing antibody is of great significance in preventing infection, while memory cell immunity can maintain a good broad-spectrum and persistence in controlling mutant strains, which is a key factor in controlling viral replication after infection and reducing severe disease and death. However, … |
CHAO WU; | 2023-02-01 |
| 496 | An Observational Prospective Clinical Study to Assess Clinical Performance of QIAstat-Dx® Respiratory Panel Plus (RPP) SARS-CoV-2 Target in The Intended Use Population and Environment PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the clinical performance of the QIAstat-Dx® Respiratory Panel Plus (RPP) SARS-CoV-2 target with a validated comparator method |
QIAGEN GAITHERSBURG | 2023-02-01 |
| 497 | A Prospective Blood Collection Study to Assess The Immunogenicity of Homologous Booster Combinations of COVID-19 Vaccines Available Under Emergency Use Authorization Among Adults of 18 Years and Older PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the immunogenicity of nationally available pre-defined homologous booster vaccination of a SARS-CoV-2 WHO EUA qualified vaccination in adults aged 18 years and older |
SANTA K DAS; | 2023-02-01 |
| 498 | A Multicentre, Open Label, Randomised, Controlled, Basket, Pragmatic, Phase II, Clinical and Translational Study to Determine The Efficacy and Safety of Plitidepsin Versus Control in Immunocompromised Adult Patients With Symptomatic COVID-19 Requiring Hospital Care PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate efficacy of plitidepsin in pre-specified groups of immunocompromised patients with symptomatic COVID-19 requiring hospital care versus control in terms of mortality. |
PHARMAMAR | 2023-02-01 |
| 499 | Optical Coherence Tomography Angiography Evaluation of Retinal and Choroidal Microvascular Parameters in School-age Children in A COVID-19 Infection Pandemic Peak in China PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We designed this study to examine whether COVID-19 infection could lead to retinal and choroidal microvascular involvement in school-age children (6-18 years) in a pandemic peak in China. |
YUEHONG ZHANG; | 2023-02-01 |
| 500 | A Randomized, Double-blind, Placebo-controlled Phase I/II Clinical Study to Evaluate The Safety, Tolerability, Pharmacokinetics Characteristics and Primary Efficacy of HS-10517 in Chinese Adult Participants PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase I/II, randomized, double-blind, placebo-controlled study to evaluate safety, tolerability, pharmacokinetics and primary efficacy of HS-10517 in Chinese adult participants. |
JIANGSU HANSOH PHARMACEUTICAL | 2023-02-01 |