Clinical Digest: Recent Clinical Trials on HPV
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to HPV. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on HPV
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | Strengthening HPV Vaccination and Adolescent Health Research Program (SHARP) in Tanzania PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Cervical cancer is a serious global public health problem, particularly in sub-Saharan Africa, where it is the leading cause of cancer in women, with around 70,722 new cases each year. Vaccination against human papillomavirus (HPV) prevents cervical cancer and is usually given to children around 9 to 15 years of age. HPV vaccination has been incorporated into many countries’ Expanded Programs on Immunization, but often faces optimization and uptake challenges. SHARP is an implementation research initiative in Tanzania, Nigeria, … |
POOJA SRIPAD; | 2025-05-01 |
| 2 | PREVENT: Practice-based Approaches to Promote HPV Vaccination in The Safety Net – Randomized Controlled Trial (RCT) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will serve as one of the first to develop and test the effectiveness of strategies to promote HPV vaccination among diverse rural parents and caregivers of children ages 9-17 years in the Mountain West. Once implemented into practice, … |
DEANNA KEPKA; | 2025-05-01 |
| 3 | Advancing Cervical Cancer Screening Through The Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer screening in the Emergency Department |
DAVID ADLER; | 2025-05-01 |
| 4 | Comparing The Antibody and B Cell Responses Induced By 1- or 2-dose 9-valent HPV (9vHPV) Vaccination in Healthy Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to answer the question: does 1-dose HPV vaccination generate the same immune responses compared to 2- or 3-dose HPV vaccination? This will be done by studying the immune response in blood, lymph nodes, and bone marrow. Human papillomaviruses (HPV) cause cancers (cervical, anal, oropharyngeal, vulvar, vaginal, and penile), and the current HPV vaccine is highly effective at preventing disease by HPV types that cause 90% of cancer cases. While this vaccine generates high levels of antibodies that last for \> 10 years, understanding of how this occurs is limited, … |
ERIN SCHERER; | 2025-05-01 |
| 5 | Circulating Tumor HPV DNA Driven Adjuvant Treatment Deintensification After Transoral Surgery for HPV-Positive Squamous Cell Carcinoma of The Oropharynx PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective phase II trial, designed to assess the efficacy and feasibility of adjuvant treatment deintensification guided by ctHPVDNA levels for patients with HPV+OPSCC who undergo transoral surgery and neck dissection. |
MICHAEL W. SIM; | 2025-05-01 |
| 6 | A Phase II Single-arm Cohort Study Establishing The Effect of Antibiotic Treatment on Intratumoral Bacteria in Surgical Patients With Oral Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this phase II single arm clinical study is to evaluate the effect of antibiotics (metronidazole) and oral chlorhexidine (CHX) in reducing the bacteria load within tumors of patients undergoing surgery for oral cancer. |
NATALIE SILVER; | 2025-05-01 |
| 7 | A Study on The Pathogenesis and Determinants of Intravenous Leiomyomatosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to learn about the impact of HPV infection in women with intravenous leiomyomatosis(IVL). The main question it aims to answer is: Does HPV infection promote the development of IVL from uterine leiomyoma? Surgical sections and HPV-DNA test results will be collected in participants diagnosed with IVL or uterine leiomyoma. |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2025-05-01 |
| 8 | A Phase I Randomized Controlled Trial of Intratumoral Lidocaine Injection Before Transoral Robotic Surgery (TORS) and Neck Dissection for HPV-Associated Oropharyngeal Squamous Cell Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Based on evidence that the local anesthetic lidocaine may have anticancer effects, this study will assess the safety and efficacy of intratumoral lidocaine injection at the time of direct laryngoscopy prior to TransOral Robotic Surgery (TORS) and neck dissection for oropharyngeal squamous cell carcinoma (OPSCC). The primary objective of the study is to determine if intratumoral lidocaine injection is safe and causes a major pathologic treatment effect in the primary tumor following surgical resection. The secondary objectives will be to determine if intratumoral lidocaine injection improves locoregional control rates, progression-free survival, metastasis-free survival, and overall survival compared to no injection. |
RYAN CAREY; | 2025-04-23 |
| 9 | Remote Resilience: Novel Applications of MHealth in Nicaragua’s Cancer Control Program PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test an mHealth intervention for cervical cancer prevention in under-screened women ages 25-64 on the Caribbean Coast of Nicaragua. The mHealth intervention combines a patient-centered mobile app, a provider portal, and connectivity to the National Breast and Cervical Cancer Surveillance System (SIVIPCAN). The mHealth intervention will be combined with HPV primary screening for cervical cancer. The main questions it aims to answer are, … |
EMMA MCKIM MITCHELL; | 2025-04-15 |
| 10 | Reengineering Cervical Cancer Screening for The 21st Century: Joint Action for A Novel Up-to-date and Sustainable Screening Program PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer screening (CCS) is important to prevent and control cervical cancer (CC). In Portugal, CCS starts with the assessment of the presence of Human Papillomavirus (HPV) in cervical-vaginal samples, collected by a health professional. However, self-sampling (self-collection of vaginal samples by the participants in CCS), is being considered in several settings, aiming to improve participation in CCS, while also exploring its potential to reduce costs. The goal of this study is to learn how self-sampling could be introduced in the CCS program in Portugal, … |
NUNO LUNET; | 2025-04-10 |
| 11 | Phase II Trial of Surgery Followed By Risk-Directed Post-Operative Adjuvant Therapy for HPV-Related Oropharynx Squamous Cell Carcinoma: The Minimalist Trial-2 (MINT-2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer. Oropharynx SCC (OPSCC) is a common sub-type of HNSCC. Each year, 16,000 new cases of OPSCC are diagnosed in the USA. Most cases of OPSCC (\>90%) are caused by the human papillomavirus (HPV) and are often cured with current therapy. However, patients treated with surgery followed by postoperative adjuvant chemotherapy and radiation therapy (POA(C)RT) still experience substantial morbidity. In this highly curable disease, current clinical research interest is focused on investigation of de-escalated therapy, … |
DOUGLAS ADKINS; | 2025-04-10 |
| 12 | HPV DNA Screening With Self-Sampling Method and Its Management in The Context of Population-Based Cervical Cancer Screening Pilot Project in Indonesia PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to implement human papillomavirus (HPV) self-collection in Indonesia. |
WIDYORINI L HANAFI; | 2025-04-01 |
| 13 | A Phase 3 Open-Label, Randomized Study of PDS0101 and Pembrolizumab Vs Pembrolizumab Alone in First-Line Treatment of Unresectable Recurrent And/or Metastatic HPV16+ Head and Neck Squamous Cell Carcinoma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a global, multi-center, Phase 3 study that is randomized 2:1, controlled, and open label to evaluate PDS0101 (Versamune + HPVMix) in combination with pembrolizumab vs. pembrolizumab monotherapy as first-line treatment in patients with unresectable recurrent or metastatic HPV16-positive HNSCC expressing programmed cell death ligand-1 (PD-L1) with combined positive score (CPS) ≥1. |
PDS BIOTECHNOLOGY | 2025-04-01 |
| 14 | De-escalation of Radiation Dose in HPV-associated Oropharyngeal Squamous Cell Carcinoma Utilising FMISO PET and Magnetic Resonance Imaging As Non-Invasive Biomarkers of Hypoxia (DE-RADIATE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this prospective clinical trial is to determine if HPV-associated oropharyngeal squamous cell carcinoma that is non-hypoxic on FMISO PET can be successfully treated with a lower dose of radiation therapy. The main questions it aims to answer are: 1. What is the pathologic complete response rate in patients selected for radiation dose de-escalation and neck dissection? 2. What is the correlation between MRI and FMISO PET assessment of hypoxia before and during RT? 3. What are the acute and late toxicities in patients selected for radiation dose de-escalation? 4. What are the quality of life scores in patients selected for radiation dose de-escalation? 5. What are the local, regional and distant failure rates of patients selected for radiation dose de-escalation? Patients with cT1-2N1-2b (AJCC 7th edition) oropharyngeal tumours will undergo surgical resection of the primary tumour. Following this, they will be allocated to standard radiation therapy (70Gy with concurrent cisplatin chemotherapy) or de-escalation radiation therapy (30Gy with concurrent cisplatin chemotherapy) based on the results of FMISO PET. Patients with non-hypoxic tumours at baseline OR after two weeks of radiation therapy will be allocated to the de-escalated group. 3-4 months after completion of radiation therapy, all patients in the de-escalated group will undergo mandatory neck dissection to assess pathologic response. Researchers will assess the pathologic response rate after surgery in the de-escalation group. They will also compare the outcomes (oncological outcomes and quality of life) between the group receiving the standard treatment (70Gy) and the group receiving de-escalated radiation therapy (30Gy). |
ANNA LAWLESS; | 2025-04-01 |
| 15 | A Multicenter, Randomized, Double-Blind, Aluminum Adjuvant-Controlled Phase III Clinical Trial to Evaluate The Efficacy, Immunogenicity, and Safety of A Recombinant Human Papillomavirus 9-Valent (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) Vaccine (E. Coli) in Chinese Males Aged 18 to 45 Years PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase III clinical trial was designed to evaluate the efficacy, immunogenicity and safety of a Recombinant Human Papillomavirus 9-Valent (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) Vaccine (E.Coli) manufactured by Xiamen Innovax Biotech CO., LTD., in Chinese males aged 18-45 years. |
JUN ZHANG; | 2025-03-31 |
| 16 | The Role of The Genital Tract Microbiota in Cervical Epithelial Cell DNA Methylation and The Increased Risk of Cervical Cancer Development PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the correlation between reproductive tract microbiota and DNA methylation in cervical epithelial cells, as well as its impact on the development of cervical cancer, through a paired case-control clinical study |
MUXUAN CHEN; | 2025-03-20 |
| 17 | Study on Novel Strategies for Cervical Cancer Screening Using Photoelectric Detection Combined with Epigenetic Procotol PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A national multicenter, open randomized controlled study was conducted. It is planned to invite 30 multi-center units across the country to compete for enrollment, and each multi-center will enroll 140 patients meeting colposcopic indications (70 in the conventional group and 70 in the experimental group), totaling 4200 patients. Enrolled subjects were randomly divided into two groups. Methylation test + colposcopic biopsy was performed in the conventional group, and clinical follow-up was performed according to the methylation results; in the experimental group, methylation test + colposcopic biopsy +OITS was performed, … |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2025-03-15 |
| 18 | Investigating Facilitator-driven, Multi-level Implementation Strategies in Federally Qualified Health Centers to Improve Provider Recommendation and HPV Vaccination Rates Among Latino/a Adolescents PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the provider- and practice-level characteristics that influence the impact of implementation strategies guided by practice facilitation in each clinical practice, to test whether the facilitator-driven provider- and practice-level implementation strategies increase provider recommendations and Human Papilloma Virus (HPV) vaccination rates and to evaluate implementation and future sustainability of the facilitator-driven implementation strategies across nine clinical practice sites |
DAISY Y. MORALES CAMPOS; | 2025-03-13 |
| 19 | Pembrolizumab for Orbital and Periocular Cutaneous Squamous Cell Carcinoma (cSCC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase II trial studies how well pembrolizumab works in treating patients with orbital (eye socket) and/or periorbital (surrounding the eye socket) cutaneous squamous cell cancer (cSCC) that has spread to nearby tissue or lymph nodes (locally advanced) or has come back after a period of improvement (recurrent). Skin cancers that are close to the eye or on the eyelid often have more genetic (heredity) changes than other types of cancers. This means that the deoxyribonucleic acid (DNA) (the building blocks of the body that determine such things as the color of the hair) in tumor tissue has been altered compared to normal tissue. It is thought cancer cells with these DNA changes are more likely to respond to a type of drug called immunotherapy. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Pembrolizumab is approved for patients with recurrent or metastatic cSCC not amenable (responsive) to cure by surgery or radiation. Giving pembrolizumab may work better in treating patients with locally advanced or recurrent orbital and/or periorbital cSCC. |
FRANCIS P WORDEN; | 2025-03-05 |
| 20 | A PRe-pOsT Interventional Study Evaluating Gardasil Nine-valent Human Papilloma Virus (HPV) Vaccine Humoral and Cellular Immune Responses in People With or Without HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2, open-label study to assess the immunogenicity of the 9-valent human papillomavirus (HPV) recombinant vaccine (Gardasil9) in people born male with current or past exposure to androgen blockers or estrogen (BM-EABE). Investigators will enroll BM-EABE with HIV and HIV negative controls (BM-EABE or men who have sex with a person with a penis (MSPP)) and administer Gardasil9 at timepoints Day 0, Month 2, and Month 6. The immune response to the vaccine will be analyzed at Month 7 (1 month following the final vaccine dose). |
OMAR HARFOUCH; | 2025-03-01 |
| 21 | Negative HPV Test Results on Infinity/GeneXpert® With The Presence of A Late Amplification Signal: What Does This Mean ? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this retrospective, single-center, observational study is to improve the diagnosis and interpretation of cervical cancer by better detection of epithelial lesions in the case of a late HPV PCR amplification signal rendered negative by routine laboratory testing using GeneXpert® technology. The various evaluation criteria are : * Presence or absence of lesions on cytological control following a negative HPV test with a late amplification signal on cervico-uterine and anal smear samples from patients seen in consultation at Brest University Hospital from 01/01/2022 to 30/06/2024 (after conventional PCR and genotyping). * Comparison of the GeneXpert® technique with the results of another conventional pan-genotypic Papillomavirus PCR test. |
CHRISTOPHER PAYAN; | 2025-03-01 |
| 22 | A Prospective, Single-center, Single-arm, Phase II Study of QL1706 Combined with Nine价HPV Vaccine As First-line Treatment for Persistent, Recurrent or Metastatic Cervical Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study medications were used as follows: 1 cycle every 21 days (3 weeks) of the following regimen. Test drug: QL1706, HPV 9-valent vaccine QL1706: Dose: 5 mg/kg ; intravenous infusion (ivgtt), administered on Day 1 of each cycle and every 3 weeks (21 days). Treatment will continue until loss of clinical benefit, occurrence of intolerable toxicity, patient or physician decision to discontinue treatment, death of the patient receiving the experimental treatment, or completion of 2 years of dosing (35 dosing cycles), withdrawal of informed consent by the subject, pregnancy of the subject, noncompliance with protocol or procedural requirements, … |
BUHAI WANG; | 2025-03-01 |
| 23 | Human Papillomavirus Ends Here: A Multilevel Intervention to Increase Uptake of The HPV Vaccine Among Adolescents PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Develop, implement, and evaluate a culturally tailored multilevel intervention to increase uptake of the HPV vaccine among eligible patients ages 10-12 of the University of California, Davis Health Community Physician (UCDH CP) primary care practices using a randomized controlled trial design. |
JULIE HT DANG; | 2025-02-28 |
| 24 | A Dose Escalation Phase I Trial of The Safety and Immunogenicity of RG1-VLP, A Candidate Broadly Protective Vaccine for The Prevention of HPV-Associated Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase I trial tests the safety, side effects, and best dose of RG1-virus-like particle (VLP) in preventing human papillomavirus (HPV)-related cancers in women. RG1-VLP is a vaccine that aims to protect against rare HPV types not targeted by currently approved HPV vaccines. HPV is a common sexually-transmitted infection that can cause certain genital and oral cancers. RG1-VLP contains a protein of HPV type 16 (HPV16) with a slightly different structure than the licensed Gardasil-9 vaccine. Gardasil-9 is approved by the Federal Drug Administration to help protect against diseases caused by some types of HPV. Gardasil-9 also contains 9 different HPV proteins. Both vaccines contain alum to stimulate the immune system. The usual approach for the prevention of HPV-related cancers for patients who are at increased risk is to consider the currently approved HPV vaccine like Gardasil-9, as well as to be followed closely by their doctor to watch for the development of cancer via routine pap smears. This trial may allow researchers to find out whether the RG1-VLP vaccine can safely trigger an immune response against HPV in healthy women and if it is better or worse than the usual approach for the prevention of HPV-related cancers. |
REINHARD KIRNBAUER; | 2025-02-27 |
| 25 | A Pragmatic Trial on Actions For Collaborative Community Engaged Strategies for HPV PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study expands on the investigators’ earlier pilot study, outlined in ClinicalTrial ID#: NCT06010108. The Actions for Collaborative Community-Engaged Strategies for HPV (ACCESS-HPV), locally referred to as 4 Girls and Women (4GW) in Nigeria, seek to utilize a participatory crowdsourcing approach to enhance HPV prevention efforts among mother-daughter dyads. Specifically, the investigators aim to 1) develop a new combined HPV vaccination and HPV self-collection campaign for mothers/daughters using crowdsourcing open calls and learning community groups, 2) determine whether the co-developed final combined crowdsourced campaign will increase HPV vaccination rates among girls and promote HPV self-collection among mothers, … |
JULIET IWELUNMOR; | 2025-02-15 |
| 26 | Validation of A Lab-free Low-cost Screening Test for Prevention of Cervical Cancer: Automated Visual Evaluation PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to validate Automated Visual Evaluation (AVE), specifically the CINFinder version developed by DL Analytics, a point-of-care screening and triage diagnostic tool for cervical cancer based on the assessment of digital images through artificial intelligence. Several teams around the world have developed versions of AVE as a triage technology but none as a screening tool. |
KARLA ALFARO; | 2025-02-12 |
| 27 | The Effect of Health Belief Model-Based Motivational Interviews on Women’s HPV-DNA Testing According to The Precautionary Acceptance Process PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this randomized controlled study was to examine the effects of Health Belief Model Based Motivational Interviewing on HPV-DNA testing in women according to the Precautionary Acceptance Process. |
MUAZEZ KÜÇÜKKAYA; | 2025-02-12 |
| 28 | A Cluster Randomized Controlled Trial Testing Communication Strategies to Increase HPV Vaccination Intention: A Survey Experiment PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This research aims to identify communication strategies to improve the uptake of vaccines using an experimental design, focusing on the Human Papillomavirus (HPV) vaccine, which is highly effective in preventing HPV-related cancers. However, low HPV vaccination rates among adults remain a significant public health challenge. Although randomized controlled trials (RCTs) have demonstrated that interventions can increase vaccine uptake in children, few RCTs have been conducted on adults. To address this gap, a multidisciplinary investigative team with expertise in communication, medicine, nursing, and behavior-change intervention research, and a history of extensive collaboration, … |
FLORENCE MOMPLAISIR; | 2025-02-06 |
| 29 | Identification of Molecular Signatures of High-risk Oncogenic HPV and Study of Their Associations with The Presence of High-grade Lesions And/or Anal Cancer 10 Years After Inclusion in The ANRS IPERGAY Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: HPVsign is a cross-sectional, non-comparative, multicenter study involving all participants included in the HPV substudy of the ANRS IPERGAY trial. The study proposes to evaluate the cumulative incidence of high-grade lesions and/or anal cancers using high-resolution anoscopy (HRA) during the HPVsign study and/or diagnosed since the end of participation in the ANRS IPERGAY trial. |
CAROLINE LASCOUX-COMBE; | 2025-02-06 |
| 30 | The Effectiveness, Cost-effectiveness, and Budget Impact of Interventions to Improve The Delivery of Cervical Cancer Screening in Puerto Rico PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer incidence is increasing dramatically (2.5% per year) in Puerto Rico (PR), with increased occurrence of regional (1.7% per year) and distant (4.7% per year) stage cancer, which reflects a real increase and indicates missed screening opportunities. Unfortunately, 80% of cervical cancer cases diagnosed in PR occur among low-income women covered by Medicaid or Medicare, who also have a 70% greater likelihood of being diagnosed with cervical cancer. Cervical cancer screening uptake continues to decline in PR, particularly among low-income Medicaid enrollees, … |
ANA P. ORTIZ MARTINEZ; | 2025-02-04 |
| 31 | Measurable Residual Disease Detection Using Tumor-Informed CtDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of The Head and Neck PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test the ability of a personalized blood test to determine which head and neck cancer patients will have a recurrence after treatment. |
DANIEL L. FADEN; | 2025-02-03 |
| 32 | Evaluation Of The Diagnostic And Prognostic Value Of Immunohistochemical Markers In Precancerous Lesions Of The Cervix PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to evaluate the expression of certain proteins and their diagnostic and prognostic value in precancerous lesions of the cervix. |
PAOLO CASADIO; | 2025-02-01 |
| 33 | Comparison Between The Efficacy and Safety of Topical Podophyllin 25% Versus Cryotherapy in The Treatment of Anogenital Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papilloma virus (HPV), is the major prevalent cause of sexually transmitted disease affecting genitalia, causing Condylomata Accuminata, also known as external genital warts or anogenital warts.¹ Occurring in men and women with a prevalence rate of 0.6-1.2% worldwide. It primarily affects those in the age range of 20-25 years. Human papilloma virus infections subclinically are primarily caused by either type HPV- 6 or HPV- 11. A vast variety of treatment options are available to treat CA , including immunomodulators ( imiquimod, purified protein derivative and the HPV vaccine), … |
NARJIS BATOOL; | 2025-01-29 |
| 34 | Unidos Contra El VPH: Screening Preference and Uptake of HPV Self-sampling Among Latinxs Along The US-Mexico Border PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the Unidos Contra el VPH study is to help find options to screen, or check, for cervical cancer that individuals can do at home to help prevent and detect cervical cancer early. Usually, … |
JESSICA CALDERON-MORA; | 2025-01-28 |
| 35 | A Randomised, Double-blind, Placebo and Positive Controlled, Phase 2 Clinical Trial to Evaluate The Safety and Immunogenicity of 15-valent Human Papillomavirus Recombinant Vaccine (Hansenulapolymorpha) in Healthy Chinese People Aged 9-45 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and Immunogenicity of 15-valent HPV vaccine in 9-45year-old participants. |
YI MO; | 2025-01-15 |
| 36 | Phase 2 Clinical Trial Evaluating Secondary HPV Vaccination After Treatment of High-grade Cervical Lesions (HPV2-2303) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-center, Phase II interventional study evaluating secondary HPV vaccination after treatment of high-grade cervical lesions. The study aims to estimate the rate of HPV clearance within two years following an initial positive HPV control test in women over 45 years of age who are chronic HPV carriers and have undergone treatment for high-grade intraepithelial cervical lesions, and who receive HPV vaccination. The study includes two cohorts: 1. Eligible patients who consent to vaccination will participate in a prospective, single-center, single-arm, interventional clinical trial (Category 2). 2. Non-vaccinated patients will be included in a non-interventional observational study, … |
CENTRE OSCAR LAMBRET | 2025-01-13 |
| 37 | RETRACE Study – Retrospective Observational Study Evaluating Disease Characteristics and Treatment Landscape of High-risk Locally Advanced (LA) or Recurrent / Metastatic (R/M) Cervical Cancer in Italy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicenter, Observational, Retrospective charts review. Observational study with descriptive purpose only. Retrospective data capture in consecutive patients diagnosed with CC who attended the Oncologic Clinics from Jan 2018 to Dec 2021 (using medical records, either electronic or not), inserted in eCRF and analyzed. |
MSD ITALIA S R L | 2024-12-17 |
| 38 | The Femscope Calm Collect Device to Obtain Cervical Cells for Cancer Screening PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to determine if cervical cells collected by the Femscope Calm Collect Device in women (sex assigned at birth) of adult age are the same quality and quantity as the cervical cells collected by the traditional brush method for cervical cancer screening. The main questions it aims to answer are: 1. Increase the number of women who get screened for cervical cancer. 2. Improve patient acceptance of getting cervical screening on a routine basis. 3. Decrease pain and discomfort for patients having a PAP smear procedure. Participants will * Have two vaginal exams to collect cervical cells. * State decreased pain and discomfort for patients having a PAP smear procedure. * The Femscope Calm Collect Device (FCCD) will be more comfortable for the patient as measured by a patient satisfaction survey comparing the FCCD and the traditional speculum method of obtaining cervical cells. |
MARILYN S FILTER; | 2024-12-12 |
| 39 | STRatIfication of Vulvar Squamous Cell Carcinoma By HPV and P53 Status to Guide Excision PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to answer the following question: Are there types of early-stage vulvar cancer that require either less or more treatment than the usual approach? |
CANADIAN CANCER TRIALS GROUP | 2024-12-10 |
| 40 | Single-Center Evaluation of The Clinical and Radiological Benefit of AHCC® in Combination with Standard of Care Treatment for HPV-Positive Patients with Head and Neck Squamous Cell Carcinoma (HNSCC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2, single-arm, open-label clinical trial determining safety and tolerability of AHCC in subjects with HPV-positive patients with Head and Neck Squamous Cell Carcinoma. These are subjects who have undergone surgery or will be undergoing surgery. |
RUPALI NABAR; | 2024-12-04 |
| 41 | Efficacy and Safety of Platelet-rich Plasma, Metformin and Cryotherapy in Treatment of Non-genital Warts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. Evaluation of the efficacy and safety of intralesional injection of autologous platelet-rich plasma in treatment of various types of cutaneous non genital warts 2. Evaluation of the efficacy and safety of intralesional injection of metformin in treatment of various types of cutaneous non genital warts 3. Comparing the efficacy and safety of intralesional injection of autologous platelet-rich plasma and intralesional injection of metformin with that of cryocautery in treatment of various types of cutaneous non genital warts. |
AYA GAMAL ABD EL-WAHAB MAHMOUD; | 2024-11-14 |
| 42 | Conversational Agents to Improve HPV Vaccine Acceptance in Primary Care PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to assess the use of and satisfaction with the ECA-HPV intervention over a 16-month period, its ability to increase HPV vaccination, and the comparative effectiveness of clinic notification and adolescent ECA components on these factors. |
MICHAEL PAASCHE-ORLOW; | 2024-11-13 |
| 43 | An Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin-Alpha) for Idiopathic CD4 Lymphopenia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Idiopathic CD4 lymphopenia (ICL) is a syndrome characterized by low levels of certain immune cells called CD4 T cells. The low CD4 T cells renders people with ICL prone to many types of severe infections, autoimmune diseases, and cancers. Although these infections and diseases can be treated whenever occur, … |
ANDREA LISCO; | 2024-11-06 |
| 44 | Stand Up 2 HPV: Standing Orders to Improve HPV Vaccination PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Each year in the U.S., ≥20,000 women and 14,000 men are affected by HPV-related cancers, including cervical and oropharyngeal cancer. However, in 2020, only 59% of U.S. adolescents aged 13-17 were up-to-date for HPV vaccination, and rates for 11-12 year olds, the primary target age group for HPV vaccination (when the immune reaction is better and before exposure to HPV infection), are even lower. Standing orders (written protocols that authorize designated members of the healthcare team to vaccinate without first obtaining a patient-specific physician order) have been shown to work in inpatient settings and for adults, … |
CYNTHIA RAND; | 2024-11-04 |
| 45 | Clinical Evaluation of Self-collected Urine Samples for The Detection of Human Papillomavirus in Males PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) infection is one of the most prevalent viral infections of the genital tract, primarily transmitted through sexual contact. Research indicates that individuals engaging in sexual activity have a lifetime probability of HPV infection as high as 85% to 90%. While extensive and in-depth investigations have been conducted on HPV infection in women, epidemiological studies focusing on male HPV infection remain relatively scarce. Many men with HPV are asymptomatic; reports suggest that approximately 10.5% of men in China are infected with HPV, … |
ZHAO YONGPING; | 2024-11-04 |
| 46 | Integrated Service Delivery to Improve Adolescent Health and HPV Vaccination in Lao PDR: A Quasi-Experimental Mixed-Methods Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to find out if adding HPV vaccination to adolescent health services works to increase HPV vaccine uptake in 10-13-year-old girls in Laos. The study will also look at the effects of adding HPV vaccination on the use of other health services in 10-13-year-old boys and girls. The main questions the study aims to answer are: 1. Does adding HPV vaccination to adolescent health services increase HPV vaccine uptake in girls aged 10-13 years compared to girls who only receive standard HPV vaccination services? 2. Does adding HPV vaccination to adolescent health services increase the use of other health services in 10-13-year-old adolescent boys and girls compared to adolescents who only receive standard HPV vaccination services? 3. What are the barriers and facilitators to using the combined intervention in Laos? 4. What are the opinions of adolescents, caregivers, healthcare providers, and other stakeholders on the combined intervention? 5. How much does it cost and how well it works to combine HPV vaccination with adolescent health services, as opposed to providing HPV vaccination alone? Researchers will compare a combined intervention to standard HPV vaccination services to see if the combined intervention works to increase HPV vaccination uptake and the use of other health services. The combined intervention includes HPV vaccination given at schools, health facilities, and through community outreach. It also includes education on sexual and reproductive health, counseling, and other health services. Participants in the combined intervention group will: 1. Receive the HPV vaccine at school or at a health facility. 2. Take part in group discussions about sexual and reproductive health. 3. Take part in individual counseling sessions. 4. Use other health services as needed. Participants in the comparison group will receive standard HPV vaccination services, including: • HPV vaccination given at schools, health facilities, and through community outreach. |
THET LYNN; | 2024-11-01 |
| 47 | NCI Cervical Cancer ‘Last Mile’ Initiative ‘Self-Collection for HPV Testing to Improve Cervical Cancer Prevention’ (SHIP) Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial evaluates the use of self-collected vaginal samples for human papillomavirus (HPV) testing in patients referred for a colposcopy and/or cervical excisional procedures to improve cervical cancer prevention. HPV is a common virus which usually causes infections that last only a few months, but sometimes can last longer. It is known to cause a variety of cancers including cancer of the cervix. Even though there are ways to detect cervical cancer early, … |
VIKRANT V SAHASRABUDDHE; | 2024-09-13 |
| 48 | Phase III Randomized and Double-blinded Trial of De-escalated Radiation in FMISO PET-selected Good Risk Versus Standard of Care Radiation in Unselected HPV Positive Oropharyngeal Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The researchers are doing this study to find out if a personalized approach to chemoradiation therapy (which may include a lower dose of radiation) is as effective as the standard chemoradiation therapy in people with HPV-positive throat cancer. Other purposes of this study include looking at the following: * Whether a lower dose of radiation in combination with standard chemotherapy causes fewer side effects than the standard dose of radiation therapy in combination with standard chemotherapy * How the study approaches (lower dose of radiation therapy + standard chemotherapy and standard dose of radiation therapy + standard chemotherapy) affect participants’ quality of life. The researchers will measure quality of life by having participants fill out questionnaires. |
NANCY LEE; | 2024-08-19 |
| 49 | What Is The Optimal Training Model for Cervical Awareness? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer represents the fourth most prevalent malignant disease and the fourth leading cause of mortality among women on a global scale. Despite screening and preventive vaccination efforts, cervical cancer remains a significant cause of morbidity and mortality in low- and middle-income countries. |
CELAL AKDEMIR; | 2024-08-15 |
| 50 | Developing and Evaluating A Novel Approach to Improve HPV Vaccination Coverage Among High-risk, Under-immunized Adults Via The Emergency Department PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine if the emergency department (ED) setting offers a viable space for improving HPV vaccination coverage among 18 to 45-year-old adults who have not yet received human papilloma virus (HPV) vaccination or who did not complete the vaccine series. This study will develop, pilot and evaluate an ED-based HPV vaccination protocol and program for ED patients aged 18-26 (for whom catch-up HPV vaccination is routinely recommended by the CDC) and separately for patients aged 27-45 (for whom it may be recommended under shared decision making, SDM). |
ANDRZEJ KULCZYCKI; | 2024-08-08 |
| 51 | An Open-Label Phase 1/2a Clinical Trial to Evaluate The Safety, Immunogenicity, and Preliminary Efficacy of A Lentiviral Vector-Based Therapeutic Vaccine Against Human Papilloma Virus (Lenti-HPV-07) in Participants with HPV-Associated Oropharyngeal Squamous Cell Cancer or Cervical Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the safety and efficacy of a potential new treatment called Lenti-HPV-07 in patients with a cancer induced by Human Papilloma Virus (HPV). The main questions aim to answer are: * Is Lenti-HPV-07 safe? * Does Lenti-HPV-07 induce an immune response? Participants will be assigned to a group based on their cancer type * either study drug group A: recurrent and/or metastatic cancer * or study drug group B: newly diagnosed with locally advanced cancer After they finish the study treatment, … |
THERAVECTYS S A | 2024-08-08 |
| 52 | Counteracting HPV Infection with Natural Molecules PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the effect of the administration of natural molecules in the treatment of HPV infection. |
AGUNCO OBSTETRICS AND GYNECOLOGY CENTRE | 2024-08-01 |
| 53 | Multidimensional Assessment of Virus-associated Head and Neck Cancer Patients for The Discovery of Predictive Biomarkers to Guide Clinical Intervention PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective pilot study, non-interventional, of a biological/radiological nature, which involves the collection of tissue samples, and blood from patients suffering from squamous cell carcinoma of the oropharynx OPSCC for detection of HPV-DNA/RNA and immuno-phenotypic analysis of T cells, study of extracellular vesicles, and dosages of cytokines and chemokines involved in the immune response |
REGINA ELENA CANCER INSTITUTE | 2024-07-24 |
| 54 | Circulating Tumor Modified HPV DNA-Guided Radiotherapy De-intensification of The Elective Neck (RaDEN) in Squamous Cell Carcinoma of The Head and Neck PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will evaluate the safety and effectiveness of a lower than standard dose of radiation for definitive or adjuvant treatment of head and neck squamous cell carcinomas. |
CHRISTOPHER MCLAUGHLIN; | 2024-06-28 |
| 55 | NCI Cervical Cancer ‘Last Mile’ Initiative ‘Self-Collection for HPV Testing to Improve Cervical Cancer Prevention’ (SHIP) Trial LMI-001-A-S01 PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial evaluates the use of self-collected vaginal samples for human papillomavirus (HPV) testing in patients referred for a colposcopy and/or cervical excisional procedures to improve cervical cancer prevention. HPV is a common virus which usually causes infections that last only a few months, but sometimes can last longer. It is known to cause a variety of cancers including cancer of the cervix. Even though there are ways to detect cervical cancer early, … |
VIKRANT V SAHASRABUDDHE; | 2024-06-26 |
| 56 | Multicenter Real-World Study of Hyperthermia in Skin/Mucosal HPV Infection of Special Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hyperthermia refers to treating diseases with temperatures beyond normal body temperature (39-45℃), and moxibustion therapy of traditional Chinese medicine belongs to the category of hyperthermia. It has been reported at home and abroad that the local temperature of 44℃ can effectively mobilize the body’s immunity and remove HPV infection lesions, such as condyloma acuminatum and verruca vulgaris. Our research group conducted randomized controlled experiments on patients with viral warts in the early clinical practice, and the cure rate of the hyperthermia group reached 45-55%, which was superior to the traditional method in the aspects of no trauma, low recurrence rate, … |
GAO XINGHUA; | 2024-06-11 |
| 57 | Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Throat cancer is a common tumor that can occur in people infected with the human papilloma virus (HPV). Most people with this cancer survive more than 5 years with standard chemotherapy drugs plus radiation. But radiation can cause serious adverse effects. Researchers believe that adding a vaccine (PRGN-2009) to this drug therapy may improve survival without the need for radiation. Objective: To test a study vaccine combined with standard chemotherapy in patients with HPV-associated throat cancers. Eligibility: People aged 18 years and older with newly diagnosed throat cancer associated with HPV. Design: Participants will be screened. They will have a physical exam and blood tests. They will have imaging scans and tests of their heart function and hearing. They will provide a sample of tissue from their tumor. A recent sample may be used; if none is available, a new sample will be taken. All participants will get two common drugs for treating cancer. These drugs are given through a tube attached to a needle inserted into a vein in the arm. Participants will receive these drugs on the first day of three 3-week cycles. Half of the participants will also get the vaccine. PRGN-2009 is injected under the skin in the arm. They will get these shots 4 times: 7 days before the start of the first cycle and on the 11th day of each cycle. Participants will have standard surgery to remove their tumors 3 to 6 weeks after completing the study treatment. They will have follow-up visits 3, 6, 12, and 24 months after their surgery. … |
CLINT T ALLEN; | 2024-06-10 |
| 58 | Real-world Study of Patients with Human Papillomavirus-positive Recurrent/ Metastatic Oropharyngeal Squamous Cell Carcinoma Treated with First Line Pembrolizumab or Nivolumab with or Without Chemotherapy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Pembrolizumab and nivolumab (with or without chemotherapy) are used to treat head and neck cancer. The middle part of the throat (oropharynx) is a common location for head and neck cancer. This cancer is known as oropharyngeal squamous cell carcinoma (OPSCC) and is most often caused by human papillomavirus (HPV) infection. This real-world evidence study carried out in the United States (US) will assess patient demographic and clinical characteristics, treatment patterns, … |
HOOKIPA BIOTECH | 2024-06-05 |
| 59 | The Role of Cyberchondria Severity in The Relationship Between HPV Awareness and Vaccination Attitudes in Adult Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) is a prevalent sexually transmitted infection linked to nearly all cases (99%) of cervical cancer. Prophylactic HPV vaccination is effective in preventing these cancers, complemented by HPV screening and treatment of precancerous lesions. The World Health Organization (WHO) aims to eliminate cervical cancer by 2030 through focused efforts on vaccination, diagnosis, and treatment. Primary prevention strategies include reducing sexual risk factors and administering prophylactic vaccines. Despite awareness of HPV testing, … |
MERVE COSKUN; | 2024-06-01 |
| 60 | Pharmacokinetics of Intravaginal, Self-administered Artesunate Vaginal Pessaries Among Women in Kenya PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study investigates the pharmacokinetics of Artesunate (AS) and dihydroartemisinin (DHA), the active metabolite of Artesunate, following intravaginal use at the dosing and frequency being studied for cervical precancer treatment. A secondary objective is to investigate safety among study participants. |
CHEMTAI MUNGO; | 2024-06-01 |
| 61 | The Effect of A Web-Based Education Program and Educational Booklet Developed on Cervıcal Cancer on Women’s Prevention Methods PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is the fourth most common cancer type among women worldwide and ranks ninth in Turkey, making it the second most common gynecological cancer. The prevention of cancer heavily relies on identifying risk factors, implementing preventive measures, and early diagnosis. Cervical cancer is associated with high-risk Human Papilloma Virus (HPV) infections, transmitted primarily through sexual contact, accounting for 99.7% of cases. Risk-enhancing factors include early sexual activity, poor hygiene, low socioeconomic status, and immunosuppressive conditions. The World Health Organization (WHO) launched the Cervical Cancer Elimination Program to address this public health issue, … |
EBRU ŞEN; | 2024-05-29 |
| 62 | Supporting The National Expansion of HPV-based Cervical Cancer Screening in Tanzania Among Women Living with HIV: NECST-HIV PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: * Cervical cancer is caused by persistent infections with one of \~13 carcinogenic human papillomavirus (HPV) types and causes substantial morbidity and mortality worldwide. * Highly effective strategies exist, … |
KAREN YEATES; | 2024-05-25 |
| 63 | The Adjuvant Effect of HPV Vaccination on Recurrence of Cervical Intraepithelial Neoplasia Grade 2 or Worse in Women Undergoing Conization: Retrospective Cohort Study PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Assessment of the association between human papillomavirus vaccination (HPV) and recurrences of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in women undergoing conization. |
MAREK PETRÁŠ; | 2024-05-01 |
| 64 | The Effect of Peer Education for Human Papilloma Virus (HPV) on Knowledge, Awareness and Concern Levels of Students in The Faculty of Health Sciences PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: According to the World Health Organization (WHO), 400 million treatable sexually transmitted diseases (STDs) such as syphilis, chlamydia and human papillomavirus (HPV) occur each year in people aged 15-49, mostly in developing countries. As HPV is a sexually transmitted virus, it has been shown to be the most important aetiological factor in cervical cancer in women (99.7%). Vaccination and education of young people about sexuality and STDs are very important in the prevention of HPV. In this respect, the aim of this study was to find out the level of knowledge, … |
BEYZANUR İŞBAY AYDEMIR; | 2024-05-01 |
| 65 | Evaluating The Feasibility and Effectiveness of A Mock-up Fact-checking Extension to Improve Ability to Debunk HPV Vaccine Misinformation Among Parents of Middle School Girls: A Survey Experiment PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this survey experiment study is to measure the impact of a mock-up Chinese fact-checking extension on the ability to dispel HPV and HPV vaccine-related misinformation among parents of middle school girls in China. |
ZHIYUAN HOU; | 2024-04-28 |
| 66 | A Pilot Study Evaluating HB-200 in Patients With Positive TTMV-HPV DNA After Definitive Treatment for HPV16 Positive HNSCC PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The researchers are doing this study to find out if HB-202/HB-201 is a feasible treatment for people with HPV 16-positive head and neck squamous cell cancer (HPV 16+ HNSCC) who have received standard treatment for their disease but then tested positive for HPV 16-related tumor DNA in the blood through a test called NavDx. Participants will have no evidence of cancer on imaging scans (radiographically) or by medical examination (clinically). Past studies have shown that a positive NavDx test strongly suggests the possible presence of microscopic cancer, … |
WINSTON WONG; | 2024-04-15 |
| 67 | Immunophenotyping, Microbiome, Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients with High-grade Cervical Intraepithelial Lesions Treated with Imiquimod PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to identify the immunophenotypic profile of the local immune response, the cervicovaginal microenvironment and the microbiological profile of women with CIN 3 treated with imiquimod. Participants will be divided in 3 groups: CIN 3 who will use 16 doses of imiquimod in the uterine cervix, applied twice a week and will be treated with LEEP procedure; 2) patients with CIN 3 who will undergo standard treatment with LEEP procedure; 3) patients with negative cytology and HPV (human papillomavirus) test. Blood and cervicovaginal lavage collections will be performed at different times, … |
BARRETOS CANCER HOSPITAL | 2024-04-02 |
| 68 | Clinical Study to Compare The Performance of Self-collected Vaginal Samples Transported Dry to Those Transported Wet for Detection of HrHPV DNA to Screen for CIN2+ Lesions PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will compare the performance of self-collected vaginal swabs, transported without liquid media (dry swabs) and self-collected vaginal swabs, transported in liquid media (wet swabs) for detection of hrHPV DNA to screen for CIN2+ lesions using LBC as the reference standard. |
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS SWITZERLAND | 2024-04-01 |
| 69 | HPV Self-sampling for Women Who Do Not Attend The Organized Cervical Cancer Screening Programme (HERSELF) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to test the effectiveness and cost-effectiveness of two different strategies of home-delivered HPV self-sampling, in comparison to the standard of care strategy, to increase adherence to cervical cancer screening. An experimental and population-based study will be implemented at three primary healthcare centers located in the Western Porto region: Cedofeita, Garcia de Orta, … |
MARIA MARGARIDA MARTINS NOVAIS TEIXEIRA; | 2024-04-01 |
| 70 | A Single Arm Phase II Trial Evaluating Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with human papillomavirus (HPV)-related oropharyngeal cancer generally have favorable outcomes and how well they do depends on the specific details about the patient and their cancer. How well they do isn’t as related to the kinds of treatment they get. However, there are significant side effects for the various types of treatments they may get. Because these patients generally have favorable outcomes no matter the kind of treatment, … |
JASON MOLITORIS; | 2024-03-07 |
| 71 | Quality of Sexual Life of PrEP Users PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will recruit participants on the occasion of their visit in a sexual health center or another HIV pre-exposure prophylaxis (PrEP) facility in France. PrEP users will be proposed to fill a self-administered, online, anonymous questionnaire regarding how they perceive different fields of their sexual life, and how they perceive that PrEP has an impact on the quality of sexual life. |
UNIVERSITY HOSPITAL GRENOBLE | 2024-03-06 |
| 72 | Screening Anal HPV Colonization in Men Sex Men Using Pre-exposure Prophylaxis for HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an interventional study investigating HPV carriage and liquid-based cytology at anal level. It will be offered to all patients undergoing PreP consultations at Besançon University Hospital. The anal swab will be taken by the doctor using a cyto-brush during the consultation. |
CENTRE HOSPITALIER UNIVERSITAIRE DE BESANCON | 2024-03-04 |
| 73 | Hospital-based Validation of The New ELEVATE Screening Tool in Belgium and Ecuador PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: ELEVATE is a six-year project, conducted by an international research alliance led by Ghent University, aiming to develop a new test and approach for cervical cancer screening in hard-to-reach populations. In this final stage of the project, a hospital-based validation study is deployed in Belgium and Ecuador to clinically validate the new ELEVATE screening test based on self-samples and endocervical samples. The simultaneous detection of HPV DNA and the proteomic markers allows for the detection of those cervical HPV infections associated with progression towards cervical cancer. At each study site, 100 women between 30-65 years old, … |
PHILIPPE TUMMERS; | 2024-03-01 |
| 74 | Phase I Dose Escalation Study of The Use of ACU-D1, A Topical Proteasome Inhibitor in HPV Associated Vulvar and Perianal Lesions in People With HIV Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to test the maximum tolerated dose of ACU-D1 in HIV-positive people with HPV-associated vulvar and perianal lesions. The main questions it aims to answer are: – The maximum tolerated dose of ACU-D1 – Safety and tolerability of topical ACU-D1 – Whether topical ACU-D1 induces p53 and p53-mediated downstream signaling (including p21 induction) in HPV-related lesions – Whether topical ACU-D1 enhances markers of immunity in HPV-infected HIV-positive individuals Participants will be asked – To apply ACU-D1 on the lesions twice daily for 4 weeks – … |
LISA FLOWERS; | 2024-03-01 |
| 75 | HPV Methylation Self-testing Pilot in Transgender Individuals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) is a common virus that spreads through skin-to-skin contact. Some HPV types can cause changes in cells that lead to cancer and are known as ‘high-risk’ HPV (hrHPV). hrHPV is linked to cancers of the cervix (opening of the womb), throat, … |
SARAH S JACKSON; | 2024-02-29 |
| 76 | A Pilot Study to Test The Effect of The Association of Epigallocatechin Gallate (EGCG), Folic Acid and Vitamin B12 in Preventing The Persistence of Human Papilloma Virus (HPV) Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to test the effect of the administration of a dietary supplement consisting of epigallocatechin gallate (EGCG), vitamin B12 and folic acid in the treatment of infections with papilloma virus of the cervix. |
LO LI PHARMA S R L | 2024-02-19 |
| 77 | Prospective Multicentric, Before After Study to Evaluate The Effectiveness and The Safety of A Medical Device in The Treatment of Common Warts and Plantar Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The principal aim of this study is to evaluate the efficacy and the safety of the tested product on common and plantar wart after 35 days of treatment. For this study, 33 patients presenting at least one common wart on the fingers, back on the hand or a plantar wart of a size between 0.1 and 0.5cm and present since less than 6 months will be included to reach this objective |
SWISS FOOTCARE LABORATORIES PODERM PROFESSIONAL | 2024-02-19 |
| 78 | Development and Validation of An Artificial-Intelligence-enabled Portable Colposcopy Device for Optimizing Triage Alternatives for HPV-based Cervical Cancer Screening PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The Pocket colposcope has 510k FDA clearance and has been successfully used in \~2500 unique patients globally in Duke and non-Duke protocols to date. 1054 women who are HPV(+) and planned to undergo treatment at 4-6 Ministry of Health-supported outpatient clinics in Kisumu County will be recruited to the study. After providing informed consent, participants will be proceed with colposcopy using the POCKET colposcope. |
MEGAN HUCHKO; | 2024-02-15 |
| 79 | Study on The Efficacy of Crispact® (Probiotic Containing Lactobacillus Crispatus M247) in The Sterilization of HPV-HR and in The Reconstitution of The Normal Vaginal Microbiota PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There is growing scientific interest in probiotic supplementation as a possible therapy for clearing the human papillomavirus (HPV) infection and reducing the risk of developement of cervical cancer. |
AMJAD KHAN; | 2024-02-10 |
| 80 | Evaluation of First-void Urine As An Alternative to Cervical Sampling for Human Papillomavirus (HPV) Testing in Cervical Cancer Screening (Single-center Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Papillomaviruses are responsible for almost all cervical cancers. In France, there are more than 3000 new cases of cervical cancer each year and nearly 1000 deaths. One of the ways to prevent this cancer is screening by PCR on cervical sample for which national coverage rate remains very insufficient (<60%). The invasive and uncomfortable nature of cervical sampling has been identified as a major obstacle to screening. In this context, an alternative sample, such as the first-void urine, seems to be judicious. Nevertheless, ... |
LOUISE MONIOD; | 2024-02-01 |
| 81 | Evaluation of Educational Interventions Targeting Beliefs About Human Papillomavirus (HPV) Among Female Employees PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effects of two different educational training programs on beliefs about Human Papillomavirus (HPV) in a group of female hospital employees. The main questions it aims to answer are: • Within the scope of the study, … |
SELVA DILAN GOLBASI KOC; | 2024-02-01 |
| 82 | Efficacy and Safety of 980nm Diode Laser Versus Liquid Nitrogen Cryotherapy for The Treatment of Plantar Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare and test the efficacy of two treatments for plantar warts. The main questions it aims to answer are: Which treatment has a higher cure rate for eliminating plantar warts? Which treatment causes less pain during the procedure? Participants with plantar warts will: Be randomly assigned to receive either cryotherapy or laser therapy Undergo 4 treatment sessions at weekly intervals Have their warts assessed for complete clearance after treatment Rate their pain levels during each session Researchers will compare the cryotherapy and laser therapy groups to see if there are differences in: Rates of complete wart clearance Pain levels reported during treatment Adverse effects |
GIULIANA SECCOLO; | 2024-02-01 |
| 83 | Safety and Immunogenicity of Human Papillomavirus Quadrivalent Vaccine Administered Intradermally and Intramuscularly Via Needle-Free Injection System PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the safety and immunogenicity of an HPV Vaccine (Gardasil) delivered by intramuscular needle-free injection and intradermal needle-free injection. The main question it aims to answer is: – Is intramuscular and intradermal needle-free injection of Gardasil safe? – Does intramuscular and intradermal needle-free vaccination with Gardasil illicit an immune response? Participants will: – Receive Gardasil by intramuscular needle-free injection, intradermal needle-free injection, or needle and syringe injection. – Provide blood samples – Complete physical exams – Complete diaries |
CISSY KARTASASMITA; | 2024-01-31 |
| 84 | Evaluation of Human Papillomavirus Vaccine Coverage in Girls and Young Women with Chronic Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of the study is to determine the vaccination coverage rate for human papillomavirus in adolescents aged 11 to 20 with chronic disease and treated at the Necker-Enfants Malades Hospital, compared to a population witnessed adolescent girls aged 11 to 20 years without chronic disease. |
SABRINA DA COSTA; | 2024-01-23 |
| 85 | Evaluation of Vaccine Chatbot on HPV Vaccine Awareness and Vaccination for Middle School Girls in China: A Randomized Controlled Trial and Implementation Science Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This interventional study targets female students in junior middle school. It goal is to evaluate the effectiveness of a vaccine chatbot on HPV vaccine awareness and vaccination. The main questions it aims to answer are: 1. How will the novel digital tool, a vaccine chatbot, impact eligible parents’ awareness and knowledge of HPV vaccines, their willingness to vaccinate their daughters, and vaccination status of female students. 2. How is the vaccine chatbots accepted by all stakeholders, … |
ZHIYUAN HOU; | 2024-01-22 |
| 86 | Biomarker Approach to Screening for The Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators seek to determine the sensitivity and specificity of a combined HPV 16 DNA and host gene methylation oral biomarker panel to distinguish early Oropharyngeal Cancer (OPC) cases from controls among 100 early and 100 late disease pre-treatment OPC cases, and 200 controls matched by sex, age, race/ethnicity, and tobacco use collected from the Moffitt Cancer Center (Moffitt) and the University of Pittsburgh Medical Center Hillman Cancer Center (Pittsburgh). |
ANNA GIULIANO; | 2024-01-22 |
| 87 | Screening with Tampons: Evaluating Diagnostic Accuracy for STIs, BV and HPV and Assessing Participant Views PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Diagnostic trial comparing the diagnostic accuracy of the DAYE Diagnostic Tampon (DDT) with a vaginal swab (self-collected and clinician taken). |
LUKE TWELVES; | 2024-01-15 |
| 88 | An Observational Study to Compare Plateau Antibody Levels of A Recombinant (E.Coli) Human Papillomavirus Nonavalent (Type 6/11/16/18/31/33/45/52/58) Vaccine Versus Gardasil®9 in Healthy Females 18-26 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to compare plateau antibody levels of a novel recombinant human papillomavirus vaccine (types 6,11,16,18,31,33,45,52,58 )(E.Coli) manufactured by Xiamen Innovax Biotech CO., Ltd., with Gardasil®9 in females 18-26 Years of Age. |
JUN ZHANG; | 2024-01-10 |
| 89 | Culturally and Linguistically Appropriate Vaccine Education (CLAVE): An Evaluation of Social Media Vaccine Communication Messages in Rural Guatemala PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test the effectiveness of culturally tailored social media campaigns and WhatsApp-based vaccine training for healthcare workers in increasing childhood routine and HPV vaccine confidence and uptake in mainly indigenous rural communities in Guatemala. Main Research Questions: * Does a culturally tailored social media campaign, deployed via Facebook and geographically targeting randomly assigned communities, … |
NADIA DIAMOND-SMITH; | 2024-01-05 |
| 90 | Vulvar Cancer Individualized Scoring System PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to develop a machine learning-based prediction model for patients with vulvar cancer. This model will utilize patient characteristics and disease features to determine the disease’s prognosis. The scoring system will also include management information to facilitate prediction of clinical outcomes of different management strategies and potential management that would yield the best prognosis. |
SHERIF ABDELKARIM MOHAMMED SHAZLY; | 2024-01-01 |
| 91 | Implementing Innovative and Strategic Approaches to Prevent and Mitigate The Deleterious Effects of HPV Across The Lifespan of Hispanics of Mexican Origin: Community Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Community members ages 18 – 45 years old from the El Paso, Texas, U.S.-Mexico Border Region will be recruited to compare psychoeducational multimedia interventions focused on the human papillomavirus (HPV). Our hypothesis is that adults who view culturally tailored multimedia stories encouraging HPV vaccination will report higher vaccination completion rates. |
EVA M MOYA; | 2024-01-01 |
| 92 | Performance of Tampons As A Biospecimen for The Detection of High Grade Disease in A Colposcopy Setting PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of the clinical performance of the Daye Diagnostic Tampon (DDT) for the detection of Human Papilloma Virus (HPV) infection associated with high grade cervical disease. Cross sectional design with comparison to a clinician taken biospecimen. Performance will be measured relative to the presence/absence of histologically confirmed disease |
KATE CUSCIERI; | 2024-01-01 |
| 93 | Assessment of Genomic Alterations and Profiles of Expression in HPV+ Versus HPV Head and Neck Cancers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Squamous cell cancers of the head and neck are classically correlated to excessive consumption of alcohol and tobacco and have a rather poor prognosis. However, the incidence of Head and Neck cancers in patients without alcohol-smoking risk factor has continued to increase in recent years, in relation to more and more frequent HPV contamination. Some studies show a difference in the expression of certain genes within the two groups of tumors (HPV+ and HPV-) including some that confer sensitivity to certain chemotherapies and others to radiotherapy. However, … |
JÉRÔME PARIS; | 2024-01-01 |
| 94 | Communicating Human Papillomavirus Vaccine With Japanese Parents and Caregivers With Daughters Aged 12-18: A Mixed-methods Assessment of Acceptance of HPV Vaccine With Experiments on Communication Strategies PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to comprehensively assess confidence in and acceptance of human papillomavirus (HPV) vaccines among Japanese parents and caregivers with daughters aged 12-18 and their decision-making process. |
LEESA LIN; | 2023-12-22 |
| 95 | Phase II Study of Enfortumab Vedotin Treatment for Metastatic Squamous Cell Carcinoma of The Penis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase II trial tests how well enfortumab vedotin works for treating patients with squamous cell carcinoma of the penis that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Enfortumab vedotin is a monoclonal antibody, enfortumab, linked to an anticancer drug called vedotin. It works by helping the immune system to slow or stop the growth of tumor cells. Enfortumab attaches to a protein called nectin-4 on tumor cells in a targeted way and delivers vedotin to kill them. |
LANCE C. PAGLIARO; | 2023-12-21 |
| 96 | Patient Decision Aid Tool for HPV Vaccination Among Adults Ages 27-45 Years Old PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn if a patient decision tool for HPV vaccination works for decision-making among adults ages 27-45. Researchers will compare a web-based patient decision tool to an information sheet to see if the tool works for decision-making. Participants will take a baseline survey, view the intervention or control condition, and then take a follow-up survey. |
ERIKA L. THOMPSON; | 2023-12-13 |
| 97 | Visual Oral Examination in Primary Health Care for Early Detection of Oral Cancer: Targeting High-Risk Individuals in The Municipality of Rio De Janeiro PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Oral cancer (OC) is a public health problem in Brazil, with high morbidity and mortality, mainly associated with late diagnosis, which implies high-cost treatments and great social impact, with aesthetic and functional sequelae. Smokers and alcoholics are at increased risk for the disease, being early detection the most effective way to increase survival. In Brazil, cancer plan recommends early diagnosis of OC through opportunistic examination, which is carried out during regular visits to the dentist. However, this strategy has not yet been able to reverse the late diagnosis, … |
MARCIA FRIAS PINTO MARINHO; | 2023-12-01 |
| 98 | Efficacy of Topical 95% Trichloroaceteic Acid in The Treatment of CIN 1 or Less After Low-grade Abnormality of Screening Test: A Randomized Controlled Trial Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy of topical 95% TCA in the treatment of CIN 1 or less after low grade abnormality of screening test |
RAJAVITHI HOSPITAL | 2023-11-30 |
| 99 | Global Burden Estimation of Human Papillomavirus (GLOBE-HPV) PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-country and multi-site project to estimate the point-prevalence of high-risk (HR) HPV genotype infections among representative samples of girls and women aged 9-50 years, and among specific sub-populations to estimate the incidence of persistent HPV infection among sexually active young women. The data to fulfill the objectives will be collected through a series of Cross-Sectional Surveys (CSS) and Longitudinal Studies (LS) in all 8 countries 3 South Asian countries including Bangladesh, Pakistan, Nepal and 5 sub-Saharan African countries including Sierra Leone, Tanzania, Ghana, … |
ALEXANDRA HILL; | 2023-11-23 |
| 100 | SELF-CERV Pivotal Study: Method Comparison of Self-collection Using The Teal Wand Self-Collection Device and HCP (health Care Provider) Cervical Collection for Detection of High-risk HPV (hrHPV) for Cervical Cancer Screening PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this method comparison study is to compare the detection of hrHPV collected using the Teal Wand Self-Collection device to hrHPV detected from HCP (health care provider) cervical collection using primary HPV testing assays. Participants will be asked to use the Teal Wand to provide a self-collected sample prior to a healthcare provider collected sample to be tested for hrHPV. Secondary measure will include usability and preferences. |
TEAL HEALTH | 2023-11-20 |
| 101 | Feasibility and Effectiveness of HPV Self-Sampling for Cervical Cancer Screening Among Women Seeking Health Care at A Safety Net Hospital Emergency Room PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to develop and evaluate an evidence-based public health intervention using HPV self-sampling approach in an opportunistic setting to increase cervical cancer screening among screening non-attendees, particularly those uninsured or underinsured, … |
AARON PETER THRIFT; | 2023-11-15 |
| 102 | Feasibility of Optimizing Organized Cervical Cancer Screening By Urine Self-sampling PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This project addresses the issue of promoting organized cervical cancer screening (CCS) from the perspective of the use of urine self-sampling (USS). Via a prospective and monocentric study, the present study aims to evaluate the acceptability of women to collect a urine self-sample and to respond to a questionnaire on their feelings about this screening method. |
UNIVERSITY HOSPITAL BORDEAUX | 2023-11-13 |
| 103 | Phase II Trial of Immunotherapeutic HPV Vaccine PRGN-2009 With Pembrolizumab Before Standard Treatment in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Cancers in and around the mouth associated with human papilloma virus (HPV) are common. Two treatments (the drug pembrolizumab and the HPV vaccine PRGN-2009) have been shown to work well when used individually against these cancers. Researchers want to find out if they might work better when used together. Objective: To test pembrolizumab combined with PRGN-2009 in people with HPV-positive cancers in and around the mouth. Eligibility: Adults aged 18 and older newly diagnosed with HPV-positive cancers in and around the mouth. Design: Participants will be screened. They will have a physical exam with blood tests. They will have imaging scans. They may need to have a biopsy: A sample of tissue will be taken from the tumor. PRGN-2009 is given as an injection under the skin. Pembrolizumab is given through a tube attached to a needle inserted into a vein in the arm. Participants will have at least 3 clinic visits: At the first, they will receive both the drug and the vaccine; 15 days later, they will receive a second shot of the vaccine. At the third visit, about 1 week after the second, they will have follow-up tests. During these visits, participants will give samples of blood, urine, and saliva. Imaging scans and biopsies will be repeated. They will have tests of their heart function. Participants may opt to return for another follow-up visit about 1 month after their second dose of the vaccine. Participants will have follow-up contacts by phone 3 and 6 months after starting the study. The calls will continue once a year for 5 years. |
CHARALAMPOS FLOUDAS; | 2023-11-07 |
| 104 | Interferon Alpha Therapy for Cervical CIN I and HPV Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Mongolia is a traditionally nomadic and population is scarce in rural areas. Thus, the medical care service is not sufficient. In 2000, Mongolian government has developed and implemented the millennium project in cooperation with WHO. During the years pap smear analysis of implemented in all rural areas and clinicians, lab technicians have been taught for the cervical cancer screening. However, … |
BATSUREN CHOIJAMTS; | 2023-11-07 |
| 105 | An Exploratory Study to Understand Women’s Values of Management of A Positive Human Papillomavirus (HPV) Test From The Cervical Screening Programme PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Almost all cervical cancers are caused by infection with a high-risk (hr) HPV. In March 2020, the Scottish Cervical Screening programme changed from a test to look for abnormal cervical cells caused by hr-HPV to a test that looks for infection with hr-HPV itself. If an HPV infection persists, there is an increased risk of a pre-cancer or cancer of the cervix developing in the future. The cervical screening programme aims to detect and treat pre-cancers, … |
UNIVERSITY OF ABERDEEN | 2023-11-06 |
| 106 | Model Study on Cervical Cancer Screening Strategies and Risk Prediction PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: By collecting non-image medical data of women undergoing cervical screening in multiple centers in China, including age, HPV infection status, HPV infection type, TCT results, and colposcopy biopsy pathology results, a multi-source heterogeneous cervical lesion collaborative research big data platform was established. Based on artificial intelligence (AI) machine learning, cervical lesion screening features are refined, a multi-modal cervical cancer intelligent screening prediction and risk triage model is constructed, and its clinical application value is preliminarily explored. |
FUJIAN MATERNITY AND CHILD HEALTH HOSPITAL | 2023-11-01 |
| 107 | Treatment With Epigallcoatechin Gallate, Hyaluronic Acid, Folic Acid and Vitamin B12 in Women HPV Positive With Abnormal Cytology Tests PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators enroll patients with a PAP-test cytology reporting LSIL or ASCUS. Pateitns undergo HPV-DNA test for screening. Patients are treated with Epigallocatechin galalte, hyaluronic acid, folic acid and Vitamin B12 by oral route. After three months of treatment PAP-test and HPV-DNA test will be repeated. |
ANDREA TINELLI; | 2023-11-01 |
| 108 | Effect of Prophylactic Use of Oral Vitamin D and Zinc in Management of The Severity of Radiation Induced Oral Mucositis of Head and Neck Cancer Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main aim of this study was to evaluate clinically the effect of a combination between oral vitamin D and oral zinc in comparison to conventional therapy in prevention of radiotherapy-induced oral mucositis in Assiut University Hospitals. |
SHOROOQ MOSTAFA KAMEL AHMED; | 2023-11-01 |
| 109 | OPERATION WIPE OUT: Multi-Channel Communication Campaign to Promote HPV Vaccination in Chambers County, Alabama PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Advisory Committee on Immunization Practices (ACIP) recommends HPV vaccination for all children and adults ages 9 to 26 in the U.S. However, HPV vaccination rates nationally and in Alabama lag far behind the Healthy People 2020 goal of 80% coverage. Despite multiple efforts, Alabama still ranks third in cervical cancer mortality and incidence nationally with great disparities within the state, particularly between urban and rural counties. In order to address this public health challenge, organizations have come together to develop, implement, … |
ISABEL SCARINCI; | 2023-11-01 |
| 110 | Randomized Pre-surgical Window-of-Opportunity Trial of TTI-101 in Patients With Stage II-IV Resectable HPV-negative Squamous Cell Carcinoma of The Head and Neck PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To learn if TTI-101 can reduce the growth of HPV-negative squamous cell carcinomas of the head and neck when given before standard of care surgery. |
ANDREW SIKORA; | 2023-10-31 |
| 111 | Prevención En Sus Manos: Feasibility of A Novel Community-Based Strategy to Improve Access to Cervical Cancer Screening PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is a disease that is preventable through vaccination against the virus that causes it, human papillomavirus (HPV), and through screening and treatment of cervical disease before it becomes cancet. |
JANE MONTEALEGRE; | 2023-10-30 |
| 112 | Prevalence of Genital, Anal and Oral HPV Infection and Sexually Transmitted Infections, and of Anal Dysplasia in The Transgender Population (PrevHPV-TG) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to estimate the prevalence of HPV infections anal and ENT level and according to HIV status in transgender (TG) population. The main question it aims to answer is: – What is the prevalence of HPV lesions in transgender population (TG); – What kind of high risk HPV (hrHPV) and low risk HPV (lrHPV) are detected at the genital, anal and ENT level |
JADE GHOSN; | 2023-10-01 |
| 113 | Randomised, Double-blind, Placebo-controlled Phase 1 Dose-escalation Study of FluBHPVE6E7 in HPV16-infected Women with NILM, ASC-US, LSIL or Low-grade CIN PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: BS-02 is a randomised, double-blind, placebo-controlled, phase 1 dose escalation study to assess the safety, tolerability and immunogenicity of FluBHPVE6E7, in women infected with HPV-16. with cervical cytological evaluation negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US), low grade squamous intraepithelial lesion (LSIL), or low-grade cervical intraepithelial neoplasia (CIN1). |
BLUESKY IMMUNOTHERAPIES | 2023-09-12 |
| 114 | The Effect of 5-aminolaevulinic Acid Photodynamic Therapy Versus C02 Laser in The Treatment of Persistent Cervical Low-grade Squamous Intraepithelial Lesions With High-risk HPV Infection:A Non-randomized Controlled Trail Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Non-RCT clinical trial comparing 5-ALA photodynamic therapy and CO2 laser for persistent high-risk HPV-related low-grade cervical lesions. |
FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY | 2023-09-11 |
| 115 | Actions For Collaborative Community Engaged Strategies for HPV (ACCESS-HPV): Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In the current pilot study, Actions for Collaborative Community-Engaged Strategies for HPV (ACCESS-HPV), we will use participatory crowdsourcing methods to drive HPV prevention among mother-daughter dyads. Crowdsourcing open calls will allow us to identify locally relevant messages and dissemination techniques to increase uptake of HPV prevention. Then, participatory learning communities will build capacity for community led implementation of selected strategies. Informed by social learning theory and the PEN-3 cultural model, … |
JULIET IWELUNMOR; | 2023-09-01 |
| 116 | The Effect of Education Given to Women on Knowledge, Attitudes and Beliefs on Cervical Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim: The aim of this study is to reveal the effect of education given to women about cervical cancer on knowledge, attitude and belief. Material and Method: This randomized controlled study was conducted with 130 who had a public hospital located in Southeast Turkey (51 experimental, 51 control). |
HATICE GUL OZTAS; | 2023-08-15 |
| 117 | Self-Collected Swabs for Primary Primary Human Papilloma Virus (HPV) Screening PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators will assess whether implementing a self-swab protocol for primary Human Papilloma Virus (HPV) testing is an effective method to increase cervical cancer screening in a sample of unscreened women in Hawaii. The findings of this study may support adoption of HPV self swab protocols both at Kalihi Palama Health Center (KPHC) and other Federally Qualified Health Centers (FQHC) in Hawaii. |
ANN CHANG; | 2023-08-08 |
| 118 | Early Phase I Window of Opportunity Biomarker and Safety Trial to Test Pyrimethamine As An Inhibitor of NRF2 in HPV-unrelated, Locally Advanced Head and Neck Squamous Cell Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: NRF2 activation, observed in up to 40% of head and neck squamous cell carcinoma (HNSCC) tumors, plays a critical role in tumor progression, metastasis, and radiation therapy resistance. The investigators have recently discovered that pyrimethamine (PYR) and its analogs have an inhibitory effect on NRF2 activity in vitro and in mouse models via inhibition of dihydrofolate reductase (DHFR). Pyrimethamine is an established drug that has been used for decades for treatment of protozoan infections and malaria. A growing body of research shows that it has potential antitumor activity, … |
PAUL ZOLKIND; | 2023-08-03 |
| 119 | Optimization of Cervical Cancer Screening Among Women Living With HIV in Latin American Countries PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is a relatively common cancer among women living with human immunodeficiency virus (HIV). This study will test women for human papillomavirus (HPV) infection of the cervix. The main purpose of this study is to determine the best way to test for damaged areas of the cervix. Damaged areas of the cervix should be treated and removed to prevent cancer of the cervix. Women in this study will be seen once, twice or three times in a year. Women will provide several samples related to screening for cervical cancer including a swab of the cervix, … |
GRANT ELLSWORTH; | 2023-08-02 |
| 120 | A Phase II Study of Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Recurrent respiratory papillomatosis (RRP) is a rare disease that causes wart-like growths in the airways. These growths come back when removed; some people may need 2 or more surgeries per year to keep their airways clear. Better treatments are needed. Objective: To see if a drug called bevacizumab can reduce the number of surgeries needed in people with RRP. Eligibility: People aged 18 and older with recurrent RRP; … |
SCOTT M NORBERG; | 2023-08-02 |
| 121 | A Phase I, First-in-human, Randomized, Observer-blinded, Placebo-controlled, Dose Escalation Study to Evaluate The Safety, Tolerability, and Immunogenicity of BV601 in Healthy Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase I, first-in-human, randomized, observer-blinded, placebo-controlled, dose escalation study to evaluate the safety, tolerability, and immunogenicity of BV601 (a HPV Vaccine) in healthy adult volunteers. |
AMBER LEAH; | 2023-08-01 |
| 122 | A Study of Reduced Dosing of The Nonavalent HPV Vaccine in Women Living with HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There are very little data on human papillomavirus (HPV) vaccination among the 18 million women living with HIV (WLWH) globally, who constitute a population most vulnerable to HPV and the resultant cervical cancer. Particularly, there are no data to date on reduced-dose schedules of nonavalent HPV (9vHPV) vaccination in WLWH and there are very little data on the 9vHPV vaccine in this population overall. It is critical to examine the 9vHPV vaccine in WLWH now because the quadrivalent HPV (4vHPV) vaccine has been discontinued. Additionally, in order to reach the World Health Organization’s global goal of cervical cancer elimination, … |
DEBORAH MONEY; | 2023-07-27 |
| 123 | Use of A Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in The AIDS Malignancy Consortium A Trial of The AIDS Malignancy Consortium (AMC) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to understand how many people with HIV (PWH) present for cancer care across the AIDS Malignancy Consortium in the United States and if there are reasons that some PWH choose to participate, or not in cancer clinical trials. Optional quality of life surveys will be used to learn more about how HIV and cancer and HIV and cancer treatment affect people. |
AIDS MALIGNANCY CONSORTIUM | 2023-07-25 |
| 124 | Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Autoimmune diseases are the consequence of an abnormality of the immune system, leading it to attack components of our own body. They have a wide variety of presentations. They preferentially affect women, and often at a young age. Systemic lupus erythematosus, for example, most often occurs between the ages of 15 and 40. Inflammatory rheumatism, such as spondyloarthritis or rheumatoid arthritis, is less prevalent in women, but also affects young people, and is particularly common. Several disease-modifying treatments exist, … |
CHRISTOPHE RICHEZ; | 2023-07-24 |
| 125 | The Efficacy of Digital Educational Interventions on Parental HPV Knowledge and Attitude, and Their Children’s HPV Vaccination Rates in Indonesia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to examine in the parental HPV knowledge and attitude, and their children’s completion rates in Indonesia. The main question[s] it aims to answer are: – Is the digital educational intervention in improving parent’s HPV knowledge in the intervention group compared to the control group? – Is the digital educational intervention in improving parent’s attitude toward HPV vaccine in the intervention group compared to the control group? – … |
YUDISA DIAZ LUTFI SANDI; | 2023-07-05 |
| 126 | A Chatbot Intervention for Reducing HPV Vaccine Hesitancy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this project is to test the efficacy of a chatbot intervention for reducing HPV vaccine hesitancy among African American parents. An online experiment will be conducted to test the effectiveness of the chatbot intervention with African American parents. Results of this project will inform future communication interventions for reducing vaccine hesitancy among African American parents. |
XIAOLI NAN; | 2023-07-01 |
| 127 | The Value of HPV Testing for Cervical Cancer Screening in Women Living With HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to evaluate the interest of a screening strategy based on the HPV test in patients living with HIV, compared to the cell smear alone in the same population. The Secondary objective of this study is to verify if the use of HPV testing could allow for a longer follow-up of these patients in case of negativity, and thus allow for a standardization of clinicians’ practices. |
CENTRE HOSPITALIER DE SAINT DENIS | 2023-07-01 |
| 128 | A Phase I Study of Intra-anally Administered Lopinavir/Ritonavir in People Living With HIV (PLWH) With High-Grade Anal Intraepithelial Neoplasia (AIN 2/3) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is being done to assess the safety of lopinavir/ritonavir in patients with PLWH with AIN. 30 participants will be recruited and can expect to be on study for up to 40 weeks. |
EVIE CARCHMAN; | 2023-07-01 |
| 129 | Predictors of Recurrence After Treatment of HPV-related Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In the recent years, the widespread adoption of primary and secondary preventions has dramatically reduced the incidence of cervical cancer in developed countries. However, cervical cancer still represents a major health concern, being the third most common malignancy among women aged <39 years, and the second most common cause of death for cancer among females between 20 and 39 years in the United States. Cervical cancer is one of the most preventable types of cancer, ... |
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI MILANO | 2023-07-01 |
| 130 | Effect of Sevoflurane and Remimazolam on Arterial Oxygenation During One-lung Ventilation: A Prospective Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to compare the effect of sevoflurane and remimazolam on arterial oxygenation during one lung ventilation in patients undergoing video-assisted thoracoscopic surgery. |
KIM HEE YOUNG; | 2023-06-29 |
| 131 | Screening Study to Determine HLA Type, HLA Loss of Heterozygosity Status and Tumor Antigen Expression in Participants With Locally Advanced (Unresectable) or Metastatic Solid Tumors PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: TScan Therapeutics is developing cellular therapies across multiple solid tumors in which autologous participant-derived T cells are engineered to express a T cell receptor that recognizes cancer-associated antigens presented on specific Human Leukocyte Antigen (HLA) molecules. The purpose of this screening study is to collect samples to conduct HLA genotyping, HLA Loss of Heterozygosity (LOH) and expression of Tumor-associated Antigens (TAA) testing. These results will be used to determine if participants meet the eligibility criteria for these parameters and could potentially be enrolled in a TScan clinical treatment study. |
SANDIP PATEL; | 2023-06-26 |
| 132 | Efficacy and Safety of Hepatitis B Virus Vaccine(HBV) in Treatment of Cutaneous Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of the work: 1. Evaluate efficacy and safety of Intralesional HBV vaccine injection as a treatment of plane and genital warts. 2. Evaluate efficacy and safety of Intramuscular HBV vaccine injection as a treatment of plane and genital warts. 3. Compare the efficacy of different doses(0.3ml vs 0.5ml )of intralesional HBV vaccine injection for treatment of plane and genital warts. 4. Compare the efficacy of intralesional HBV vaccine injection vs Intramuscular HBV vaccine injection in treatment of plane and genital warts. |
MARIA AWNY ARMIA; | 2023-06-10 |
| 133 | Evaluación De La Eficacia De La Combinación De GLIZIGEN® Solución Oral 1/día Y Gel Vaginal 1/Noche Durante 2 Meses En Pacientes Con Neoplasia Intraepitelial Cervical De Grado 1 (LSIL/CIN-1) Causada Por El Virus Del Papiloma Humano De Alto Riesgo (VPH-AR) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: HPV infection can lead to cancer, especially when precancerous lesions have developed and high-risk HPV is present. Glizigen is an oral and intravaginal treatment based on activated glycyrrhizinic acid that has shown potential benefit in patients with HPV. In order to improve the existing evidence, the present study consists of a randomized, double-blind, placebo-compared clinical trial to evaluate the efficacy of combined treatment with Glizigen Oral Solution and Glizigen Vaginal Gel for the resolution of biopsy-confirmed grade 1 cervical intraepithelial neoplasia (CIN-1) in patients with high-risk HPV. |
PLUVIO J. CORONADO MARTÍN; | 2023-06-07 |
| 134 | An Observational Database Study to Monitor Safety-related Endpoints After Marketing of Cecolin® PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was a retrospective-prospective real-world study to assess the safety among females receiving the 2vHPV vaccine (CecolinⓇ). |
XIAMEN INNOVAX BIOTECH | 2023-06-06 |
| 135 | A Clinical Audit on Screening Program for Early Cervical Cancer Detection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to audit results and adherence to Cervical Screening program before and after the implementing awareness of the WHO guidelines of screening among the multidisciplinary healthcare workers and patients. |
MOHAMED MOSTAFA ABDELRAOF SOLIMAN; | 2023-06-01 |
| 136 | A Phase 1 Trial of TGN-S11 in Patients With Human Papillomavirus (HPV)-Associated Relapsed, Resistant or Metastatic Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label, non-randomized, Phase I, dose escalation/dose expansion study in cohorts of patients with relapsed, resistant, or metastatic HPV-associated cancers. The Expansion Phase will begin in parallel one dose level lower than the highest dose deemed safe in the Dose Escalation in combination with a PD-1 checkpoint blockade. |
TORAGEN | 2023-06-01 |
| 137 | Phase 2a Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial To Evaluate The Safety And Efficacy Of Topical Nitric Oxide Releasing Solution For The Treatment Of Human Papillomavirus Verrucae Plantaris PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A phase 2a multicenter, randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety and efficacy of topical nitric oxide releasing solution (NORS) for the treatment of human papillomavirus (HPV) caused verrucae plantaris (plantar warts). Participants will be treated over a 21 day period with a final evaluation on Day 35. They will be separated into 3 treatment groups (placebo, 1x and 2x dose). Participants will be evaluated for change in wart size, wart clearance, and HPV genotype. |
SCOTT SCHUMACHER; | 2023-06-01 |
| 138 | Implementation of Evidence-Based Strategies to Optimize HPV Vaccination in Rural Primary Care Settings PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the implementation of evidence based strategies to optimize HPV vaccination in rural primary care settings. Some of the largest disparities in human papillomavirus vaccination (HPVV) rates exist in rural communities, … |
ELISA RODRIGUEZ; | 2023-05-24 |
| 139 | Implementing An Evidence-Based, Multilevel Intervention to Promote HPV Vaccination Among HIV Positive Adults PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: People living with HIV (PLWH) are 28 times more likely to be diagnosed with Human Papillomavirus (HPV) – associated anal cancer than the general population. The HPV vaccine is an effective and safe approach to prevent and reduce the risk of HPV-related disease among PLWH. HPV vaccine programs tailored and implemented in the HIV population are lagging for this high-risk group. The CDC’s 4 Pillars Transformation Program is a multi-level, evidence-based intervention that has been successfully used to increase HPV vaccination in the general population and is ready to be tested in the high-risk HIV population, … |
JESSICA WELLS; | 2023-05-22 |
| 140 | COVIDVaxStories: A Pilot Double-blind Randomized, Parallel Design Trial of Storytelling to Reduce COVID-19 Vaccine Hesitation in Populations of Color Using A Respondent-driven Sampling Design PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pilot randomized controlled trial testing the investigator’s previously developed storytelling method to create an interactive, multi-media storytelling intervention to address community-identified reasons for vaccine hesitancy among Black and Hispanic individuals in Central Massachusetts |
JEROAN ALLISON; | 2023-05-19 |
| 141 | Clinical Decision Support Tools to Increase HPV Vaccination in Pharmacies PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial develops and tests how well a clinical decision support (CDS) tool works to increase human papillomavirus (HPV) vaccination of children between the age of 9-17 (adolescents) in pharmacies. HPV vaccination rate in eligible adolescents remains low even though over 90% of the cancers in adults caused by HPV can be prevented by the HPV vaccine. The National Vaccine Advisory Committee recommends HPV vaccinations to be given in pharmacies to increase access to vaccines, … |
PARTH SHAH; | 2023-05-14 |
| 142 | Research for The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is one of the most common cancer in women, making it the fourth largest cause of female cancer mortality worldwide. High-risk HPV types (hrHPV) continuous infection is the main cause of the premalignant and malignant lesions of the cervix. The most effective primary prevention of cervical cancer is administration HPV vaccines. There are three prophylactic HPV vaccines including bivalent HPV (2vHPV)， quadrivalent HPV vaccine (4vHPV)，9-valent HPV vaccine (9vHPV) currently. With the widespread of HPV vaccination， the cases related to abnormal menstrual cycle or menstrual irregularities has gradually increased in the Vaccine Adverse Event Reporting System, … |
XIAO JUAN; | 2023-05-04 |
| 143 | Assessment Of Gene Expression Of Suppressor Of Cytokine 3, Interferons Alpha And Beta In Cutaneous Warts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Warts are common epidermal growths caused by various strains of human papilloma virus (HPV). Viral warts are common with a prevalence rate of 7-12%. Human papilloma virus is small non enveloped viruses that contain a double-stranded DNA genome. There are more than 200 HPV genotypes are reported, however, the high-risk types, including HPV genotype-16 (HPV16), 18, 31, and 45, are the causes of 80% of cervical cancers. |
REHAM HELAL ABOELHAMD; | 2023-04-15 |
| 144 | Radiosensitivity of HPV-related Tumors: Towards A Genomic Approach – ICARUS Project PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is therefore to analyze the genomic profiles of prognosis and radiosensitivity of Human Papilloma Virus (HPV) related tumors from different body sites (oropharynx, uterine cervix, and anus), considering them as a unified entity regardless of the site of origin within the body. |
DANIELA ALTERIO; | 2023-04-14 |
| 145 | A Phase 1 Study to Assess The Feasibility and Safety of Tumor HPV-E6/E7-Targeting T Cell Suspension for Intravenous Infusion (HPV-T) in Patients With HPV-16 Positive Recurrent or Metastatic Solid Tumor PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this protocol is to evaluate the feasibility and safety of HPV-T in HPV 16 positive recurrent or metastatic solid tumor patients. |
BGI CHINA | 2023-04-13 |
| 146 | Cervical Cancer Screening Based on First-void Urine Self-sampling to Reach Un(Der)-Screened Women: Dry Run of The ScreenUrSelf Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study is the Dry Run preceding the ScreenUrSelf trial. |
PIERRE VAN DAMME; | 2023-04-10 |
| 147 | A Phase I/Ib, Open-label, Multi-center, Study of QEQ278 in Patients With Advanced Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To characterize safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of QEQ278 in adult patients with advanced/metastatic non-small cell lung cancer, esophageal squamous cell carcinoma, renal cell carcinoma, and human papilloma virus associated head and neck squamous cell carcinoma. |
NOVARTIS PHARMACEUTICALS | 2023-04-04 |
| 148 | Self-collected Cervical Cancer Screening Samples for Detection of Human Papillomavirus in HIV-positive Women – A Pilot Study of Self-collected Vaginal and Urine Samples PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study assesses topics as Human Immunodeficiency Virus (HIV), Human Papilloma Virus (HPV), and cancer screening methods. The focus will be on evaluating feasibility of implementing novel cancer screening modalities in a low-resource setting in Guinea-Bissau and further to estimate the prevalence of the precancerous virus HPV amongst women living with HIV. In the study we will collect urinary and vaginal self-samples for HPV testing, and further evaluate the feasibility of implementing the devices as screening modalities through questionnaires given to the women. |
SANNE JESPERSEN; | 2023-04-01 |
| 149 | The Prevalence of Oral HPV Infection and Oral Lesions in People Living With HIV in A HIV Primary Care Clinic PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will evaluate 300 people living with HIV that attend the Vivent Clinic for HIV care. We will characterize our population and include age, race/ethnicity, sex at birth, tobacco use, alcohol use, other comorbidities, HPV vaccination status, other HPV disease, and lab values such as CD4 count and HIV viral load. We will compare results between participants who are HPV positive and negative. We will also evaluate the relationship between HPV oral infections and lesions and the variables above to better understand possible predictors of HPV infections and lesions. |
CINDY FIRNHABER; | 2023-04-01 |
| 150 | A First-in-human, Phase I, Single-center, Open-label, Dose-escalation Trial in Healthy Volunteers to Assess Safety, Tolerability, and Immunogenicity of PANHPVAX, A Vaccine Targeting Human Papilloma L2 Antigen Formulated With Cyclic Di-AMP PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: First-in-human, phase I, single-center, open-label, dose-escalation trial in healthy volunteers. Investigation of safety and tolerability of ascending doses of PANHPVAX, a vaccine against human papilloma L2 antigens formulated with cdA (adjuvant) as compared to the formulation without cdA. |
ANTJE BLANK; | 2023-04-01 |
| 151 | Increasing Cancer Screening Among Female Patients at PSH St. Joseph’s Residency Clinic: Offering A Self-sampling Option in Clinic PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effectiveness of offering self-sampled human papillomavirus (HPV) tests in increasing participation in cervical cancer screening, compared to the standard of care clinician-sampled test. The primary study endpoints are (1) patients’ acceptability of self-sampled HPV tests vs. clinician-sampled test, and (2) patients’ completion of self-sampled HPV test. The secondary study endpoint to be measured is the increase in cervical cancer screenings of any type in the PSH St. Joseph’s residency clinic patient population. |
CHRISTINA SCARTOZZI; | 2023-04-01 |
| 152 | Adjuvant Chemotherapy in Cell-free Human Papillomavirus Deoxyribonucleic Acid (cfHPV-DNA) Plasma Positive Patients: A Biomarker In Locally Advanced Cervical Cancer (CC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study hypothesizes that patients who persist with cell-free human papillomavirus deoxyribonucleic acid (cfHPV-DNA) plasma expression at the end of standard treatment, can derive the benefit of using adjuvant chemotherapy in locally advanced cervical cancer (CC). After standard treatment based on concomitant chemoradiotherapy regime, … |
MICHELLE S ALMEIDA; | 2023-04-01 |
| 153 | A Phase II Trial of T Cell Receptor Gene Therapy Targeting Human Papillomavirus ( HPV) 16 E7 for HPV-Associated Cancers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II clinical trial to assess the clinical activity of immunotherapy with E7 TCR-T cells for metastatic HPV-associated cancers. HPV-associated cancers in include cervical, throat, penile, vulvar, vaginal, anal, and other cancers. Participants will receive a conditioning regimen, E7 TCR-T cells, and aldesleukin. Clinical response to treatment will be determined. |
CHRISTIAN HINRICHS; | 2023-03-30 |
| 154 | The DelVIN Trial – A Multicenter Phase I Trial Evaluating The Safety and Preliminary Efficacy of Local Decitabine Treatment of Human Papillomavirus (HPV)-Induced Vulvar Intraepithelial Neoplasia (VIN) Grade 2/3 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicentre open labelled phase I trial evaluating the safety and preliminary efficacy of local decitabine treatment of human papillomavirus (HPV)-induced vulvar intraepithelial neoplasia (VIN) grade 2/3. The main purpose and primary objective of the study is to determine the recommended phase 2 dose (RP2D) of VTD-101 ointment for the topical treatment of HPV-induced VIN grade 2/3. The RP2D is defined as the dose that is safe, … |
VIMREX | 2023-03-28 |
| 155 | Offering Home-based Versus Hospital-based HPV Counceling and Testing for Cervical Cancer Screening in Rural West Region of Cameroon: A Randomised Cluster Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is a public health problem in Cameroon.In 2020, the country had a crude incidence of 20.2 per 100 000 women for an incidence to mortality ratio of 0.65. As for now, the country does not have a national screening program to combat the disease. Only 6% of cameroonian women have once been screened for cervical cancer. In order to increase screening uptake so as to reach 70% recommended by WHO, we propose a home-based cervical cancer screening approach. The objective of our study is to compare two recruitment strategies for cervical cancer screening in rural Cameroon. |
PATRICK PETIGNAT; | 2023-03-27 |
| 156 | Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to explore whether an anti-cancer medication (5-fluorouracil cream) placed in the vagina after a surgical excision procedure is an acceptable and useful form of treatment for cervical precancer among the woman with HIV infection. |
CARLA CHIBWESHA; | 2023-03-22 |
| 157 | Evaluation of Oropharyngeal and Anal Swab Samples in Patients With HPV Positivity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients whose pathology results are reported as cervical intraepithelial neoplasia (CIN) 1, CIN 2, and CIN 3, are recruited. We aimed to evaluate HPV-positive women presenting to the Obstetrics and Gynecology clinic, whose cervical pathology results were reported as CIN 1, CIN 2, and CIN 3, by collecting oropharyngeal and anal swab samples. A total of 30 women of reproductive age, who consented to participate, were included in the study. |
TUGBA AKCAOGLU; | 2023-03-14 |
| 158 | Appalachian Voices for Health – Feasibility Trial of A Multi-level Media Production and Social Marketing Campaign to Reduce HPV Vaccine Hesitancy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Since 2019, the HPV working group of the University of Virginia Cancer Center’s Southwest Virginia Community Advisory Board has developed and executed strategies to increase regional HPV vaccination rates. Members collaboratively developed Appalachian Voices for Health, a multi-level media production and social marketing intervention. This novel intervention builds on the past efforts of the working group and the engaged organizations; takes into account the impact of vaccine hesitancy on HPV vaccination uptake; and incorporates best practices. Through the intervention, … |
KATHLEEN PORTER; | 2023-03-13 |
| 159 | Engaging Clinical Champions to Improve HPV Vaccine Communication and Uptake in Healthcare Systems PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial will compare two ways to improve communication about HPV vaccination in primary care. The research team will work with primary care clinics. Some clinics will receive communication training from an outside expert. Other clinics will receive the same training from a vaccine champion from their healthcare system. |
NOEL T BREWER; | 2023-03-08 |
| 160 | Extraordinarily Fun Training Project in Compulsory Secondary Education-Sexually Transmitted Infections: Educational Intervention on STI in Adolescents From 1st&2nd Year of Compulsory Secondary Education Incorporating The Gender Perspective PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Project FEDE-ITS will improve the STI knowledge and its treatment, of adolescents in the 1st and 2nd year of compulsory secondary education in the intervention group compared to compared to the control group, and will modify the sexual risk practices and the perception of risky practices of alcohol and other drug use during sex of participants in the intervention group compared to the control group. |
DAVID PEDRAZAS-LÓPEZ; | 2023-03-01 |
| 161 | Effects of Estrogen-like Chinese Medicine and Vaginal Lactobacillus on HPV Clearance and Vaginal Microbiota Change in Women With Persistent HPV Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: High risk human papillomavirus (hr-HPV) persistent infection is a high risk factor for cervical cancer. 85% to 90% of hr-HPV infections have the ability to clear on their own, while 10% to 15% of HPV persists further will lead to the development of high-grade intraepithelial lesions (HSIL) and even to invasive cervical cancer. Long-term follow-up results for persistent hr-HPV infection showed that cervical HSIL mostly occurred after 5-7 years of persistent hr-HPV infection, among which the risk of HPV16 and 18 was the highest, … |
MINGZHU LI; | 2023-03-01 |
| 162 | Carrageenan for The Prevention of Oral HPV Infection: A Feasibility, Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a placebo-controlled, triple-blind randomized clinical trial (RCT) designed to evaluate the feasibility of conducting a larger multicentric RCT investigating the effect of a Carrageenan mouthwash on oral HPV infection. Eligible participants will complete a single in-person visit at baseline, filling out a questionnaire on their electronic device and giving an oral rinse sample for HPV testing. They will receive an adequate supply of mouthwash and instructions on its use. They will subsequently be followed up for up to six months. Every two weeks, … |
BELINDA NICOLAU; | 2023-03-01 |
| 163 | Dexmedetomidine Improves Oxygenation and Reduces Pulmonary Shunt in High-Risk Pediatric Patients Undergoing One-Lung Ventilation for Thoracic Surgery: A Double-Blind Randomized Controlled Trial at Damascus University Children’s Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Children with high anesthetic risk who underwent Thoracic surgery with OLV (one lung ventilation) technique during general anesthesia were divided into two groups. The first is an intravenous injection of dexmedetomidine at a rate of 0.4 micrograms/kg/hour as a continuous intravenous infusion. The second group, the placebo group, injected the second with a normal saline solution, an infusion that will pass through the vein, using blinded, unmarked syringes. Three arterial blood gas (ABG) samples were taken during surgery at designated times. Circulatory PaO2 values were recorded and the Qs/Qt shunt value was calculated. |
DAMASCUS UNIVERSITY | 2023-03-01 |
| 164 | Fertility: Infection and Inflammation PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators explore whether inflammatory factors and infections in collected samples are altered in fertility issues and if they can predict pregnancy outcomes. The investigators focus on pro- and anti-inflammatory markers, such as cytokines, metabolic parameters (e.g., blood lipids, hormones, bile acids), and viral infections (e.g., HPV, herpesviruses). A standard blood panel is also performed. Fertility issues are rising due to aging, infections, environmental toxins, and lifestyle factors (e.g., BMI, diabetes). Fertilization and implantation involve complex interactions between the egg, sperm, embryo, and endometrium, which can be disrupted by inflammatory processes from infections, metabolic imbalances, … |
URSULA HIDEN; | 2023-02-28 |
| 165 | Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To learn if SAR444245 given in combination with cemiplimab can help to kill cancer cells in patients with HPV-related oropharynx cancer who are scheduled to have surgery to remove the disease |
RENATA FERRAROTTO; | 2023-02-28 |
| 166 | Reducing Cervical Cancer Screening Disparities in Somali Immigrant Women Through A Primary Care-based HPV Self-sampling Intervention PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study plans to assess the effect of implementing HPV self-sampling in primary care on uptake of cervical cancer screening in 30-65 year old Somali women who are due for cervical cancer screening. |
REBEKAH PRATT; | 2023-02-20 |
| 167 | Surgeon-performed Intraoperative Transoral Ultrasound in Patients With Suspected Head and Neck Squamous Cell Carcinoma of Unknown Primary: A Prospective Diagnostic Accuracy Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Adult patients suspected of Squamous Cell Carcinoma of Unknown Primary (SCCUP) will be prospectively enrolled at a tertiary head & neck cancer center at Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark. All patients will undergo Magnetic Resonance Imaging (MRI) and Positron Emission Tomography-Computerized Tomography (PET-CT) prior to examination in general anesthesia. During general anesthesia, Intraoperative Transoral Ultrasound (ITUS) will be performed prior to panendoscopy. Detected tumors will be registered with specified oropharyngeal sub-locations. Blinded to ITUS, a consultant head & neck surgeon will perform panendoscopy. After examination, … |
MARTIN GARSET-ZAMANI; | 2023-02-15 |
| 168 | A Phase II Double Blind, Placebo-controlled, Randomized Trial of Artesunate Suppositories for The Treatment of HIV-negative Patients With Anal High-grade Squamous Intraepithelial Lesions (Anal HSIL) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II double blind, placebo-controlled, randomized study of Artesunate suppositories for the treatment of HIV-negative men and women who have anal high grade squamous intraepithelial lesions (anal HSIL) |
JOEL PALEFSKY; | 2023-02-10 |
| 169 | Project CONTINUITY: Promoting Evidence-Based Cancer Screening Among Underserved Women PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Project CONTINUITY (Connecting You to Care in the Community) was developed to increase adherence to cervical cancer screening regimens from initial screening to needed follow-up care by (1) providing personalized approaches to improve adherence through the combined use of patient choice for the initial screening method (Pap/HPV co-testing vs. HPV self-test collection), community clinical navigators and community health workers (CHWs), customized messages and support for patient portal access for test results and (2) implementing strategies to address social determinants of health (SDoH) that may influence an individual’s ability to adhere to the screening regimen, … |
ELIZABETH A SHENKMAN; | 2023-02-01 |
| 170 | Development and Psychometric Testing of A Questionnaire to Assess HPV Knowledge in Indonesia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to develop and conduct psychometric testing of a new scale, the Human Papillomavirus Knowledge Scale (HPV-KS), particularly designed to assess HPV knowledge among parents of school-age children in Indonesia. |
YUDISA DIAZ LUTFI SANDI; | 2023-02-01 |
| 171 | Liquid Biopsy for Early DiagNosis of Squamous Cell Carcinoma of The HeAd and NeCk REgion (ENHANCE Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The 5-year survival for Head and Neck squamous cell carcinoma (HNSCC) across all TNM stage groups is approximately 50%. Patients who are present with stage I & II disease have significantly better survival. When a patient presents to their general practitioner (GP) with symptoms suggestive of HNSCC, they may be referred for urgent specialist input through the suspected cancer referral (SCR) pathway, which include dedicated neck lump clinics. HNSCC is known to shed fragments of DNA, … |
ENYI OFO; | 2023-02-01 |
| 172 | Clinical Correlation Between Self-collected and Physician-collected HPV Screening Kits PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to validate the of the Evalyn®Brush via self-collection to the standard clinician-collected technique using the BD SurePath™ collection vial and Rovers CombiBrush for detection of Human Papillomavirus (HPV). This study will validate the sensitivity and specificity of the Evalyn Brush with the future goal of making this testing approach available for self-collection in the future. |
KARAM RAMOTAR; | 2023-02-01 |
| 173 | Implementing Innovative and Strategic Approaches to Prevent and Mitigate The Deleterious Effects of HPV Across The Lifespan of Hispanics of Mexican Origin – Healthcare Provider Intervention PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Healthcare providers (HCP) serving the El Paso U.S.-Mexico Border Region will be recruited to compare educational and professional skills interventions focused on the human papillomavirus (HPV). Our hypothesis is that improving provider knowledge and communication strategies about HPV and its vaccine will reduce hesitancy and increase uptake and completion among the populations they serve. |
EVA MOYA; | 2023-02-01 |
| 174 | Performance of Large Loop Excision of The Transformation Zone (LLETZ) in Women With Cervical Dysplasia in The Follicular Phase Versus The Luteal Phase of The Menstrual Cycle: A Prospective Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the preventive smear test at the gynecologist and can thus contribute to a 100% chance of cure if they are clarified by a colposcopic examination as part of the dysplasia consultation and dysplastic lesions are then surgically removed if necessary (conization). There are few data in the literature on the influence of the menstrual cycle on the bleeding pattern during and after conization. Hormonal variations during the menstrual cycle affect both the extent of blood flow to reproductive organs and hemostasis. In the follicular phase, there is a decrease in local blood flow in the uterus and pelvic organs and an increase in coagulability. Conversely, in the luteal phase there is an increase in local blood supply and a decrease in coagulability. Therefore, it seems reasonable to perform conization in the follicular phase to possibly reduce the extent and incidence of bleeding and bleeding complications. This assumption is supported by clinical observations. For example, there is evidence from other specialties that selection of the timing of surgery, taking into account the menstrual phase, may influence the risk of bleeding. Another factor of interest in menstruation-based surgical planning is psychological vulnerability, which may also vary with the menstrual cycle. Until now, consideration of the menstrual cycle in surgical planning for conization has not been standard practice and there is no recommendation in this regard in the current S3 guideline of the German Society of Gynecology and Obstetrics. Therefore, this study now aims to answer the question under prospective randomized conditions whether LLETZ conization performed during the follicular phase results in lower blood loss and higher patient satisfaction and lower anxiety scores compared to LLETZ conization performed during the luteal phase. |
CLEMENS TEMPFER; | 2023-02-01 |
| 175 | Using A Community-based Participatory Approach to Reduce Disparities in Cervical Cancer Prevention, Screening, and Diagnosis Among Hispanic Women in Cleveland Related Papers Related Patents Related Grants Related Experts View Highlight: This study offers Hispanic women who are eligible for cervical cancer screening residing in the Cleveland metropolitan area one of two possible community outreach-based cervical cancer screening modalities, self-collection home HPV test or clinic-based pap test, which is the current standard of care, to assess if these strategies improve cervical cancer screening rates in this population group. |
KIRSTEN Y EOM; | 2023-02-01 |
| 176 | Incidence of Human Immunodeficiency Virus (HIV) Among Indian Men Who Have Sex With Men (MSM) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research trial studies the incidence of human immunodeficiency virus (HIV) infection in screening Indian men who have sex with men (MSM). Gathering health information over time from Indian MSM may help doctors determine how many Indian MSM develop new cases of HIV infection. |
JOEL PALEFSKY; | 2023-01-30 |
| 177 | Investigating Human Papillomavirus (HPV) Infection and HPV-Associated Disease in Indian Men Who Have Sex With Men Who Are HIV-Positive PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research trial studies the incidence of human papilloma virus (HPV) infection and HPV-associated disease in screening Indian men who have sex with human immunodeficiency virus (HIV)-positive men. Gathering health information over time from Indian men who have sex with men (MSM) may help doctors determine how many HIV -positive MSM develop new HPV infections and how many HIV-positive MSM have HPV related disease. |
JOEL PALEFSKY; | 2023-01-30 |
| 178 | A Phase II Study of Shortened Course, Dose De-Intensified Adjuvant Radiotherapy Following Transoral Robotic Surgery (TORS) and Neck Dissection for P16+ Oropharyngeal Squamous Cell Carcinoma PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single-arm, phase II study to establish the safety of reducing radiation dose in selected p16+ OPSCC patients receiving adjuvant radiation after TORS and neck dissection. This protocol also allows for sparing of the primary resection bed, in appropriate patients, as previously published by our group and found to be safe and effective. |
ALEXANDER LIN; | 2023-01-30 |
| 179 | Feasibility Study of Ocular Surface Squamous Neoplasia (OSSN) Surgical Excision in People Living With HIV in Sub-Saharan Africa (SSA) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Participants will undergo surgical excision of OSSN at baseline and will be followed at 1 week, 6 weeks, 6 months, and 12 months for post-surgical follow up. This study is being conduced to assess the feasibility of conducting multi-center prospective studies on surgical excision of suspected OSSN lesions in SSA in people living with HIV/AIDS (PLWHA). Participants include those with HIV infection and with suspected non-invasive OSSN lesions that the AMC-certified ophthalmologist determines can be resected with 3 mm clinical margins, sparing involvement of the superior and inferior fornices and 6 clock hours of the corneal scleral limbus. |
AIDS MALIGNANCY CONSORTIUM | 2023-01-28 |
| 180 | Evaluation of The Efficacy and Safety of An AHCC®-Based Supplement (Lentinula Edodes) in Promoting Negativity of Persistent HPV Infection: A Retrospective Multicenter Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This retrospective, multicenter clinical study evaluates the efficacy and safety of an AHCC®-based supplement derived from Lentinula edodes in promoting the negativity of persistent HPV infection lasting more than six months. The study involves three groups: unvaccinated participants receiving AHCC®, vaccinated participants receiving both AHCC® and the HPV vaccine, and vaccinated participants receiving only the HPV vaccine. |
AMJAD KHAN; | 2023-01-02 |
| 181 | Study on The Epidemiological Characteristics of Female Different HPV Vaccination in China PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) is currently one of the most common sexually transmitted infections, according to its carcinogenicity is divided into high-risk genotypes and low-risk genotypes, studies have confirmed that carcinogenic HPV type continuous infection leads to higher incidence of condyloma acuminatum and cervical cancer, while increasing the risk of oropharyngeal cancer, vaginal cancer and other related cancers. Human papillomavirus vaccines have been widely used worldwide to prevent cancers of the lower reproductive tract, such as cervical, anal and vulvar cancers. According to the type, it is divided into domestic two-valent (Vantage), imported two-valent (GlaxoSmithKline), … |
BINHUA DONG; | 2023-01-01 |
| 182 | A Cross-sectional Study to Evaluate The Prevalence of HPV in Gay and Bisexual Men Aged 21-25 Years in Australia PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Anal cancer is overrepresented among gay, bisexual and other men who have sex with men (MSM), particularly those living with HIV. Australia was the first country to introduce a publicly funded national HPV vaccination program in 2007. This program was expanded to include schoolboys aged 12-13 years in 2013; with a 2-year catch-up for boys aged up to 15 years. The goal of the HYPER4 study is to determine the prevalence of anal, … |
ERIC CHOW; | 2023-01-01 |
| 183 | Circulating Cell-Free Tumor Tissue Modified Viral (TTMV)-HPV DNA As A Biomarker For Early Cancer Detection Among Human Subjects With HPV-Induced Dysplasia In Female Genital [Uterine Cervix, Vaginal and Vulvar] Organs: A Clinical, Translational and Biomarker-Based Cancer Screening Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Uterine cervical dysplasia and other female genital dysplasia continue to be significant health problems despite Cervical Screening Programs and HPV vaccinations being available. These female genital dysplasia [FGD] induced by HPV infections affect disadvantaged women in the US and globally more than others: minorities like African Americans [AA], rural populations, lower socioeconomic strata of the society and less educated in the US and lower / middle income countries. The reasons are: lack of access to screening and vaccines, lack of infrastructure, … |
UNIVERSITY OF MISSISSIPPI MEDICAL CENTER | 2023-01-01 |
| 184 | Detection and Prevalence of Human Papillomavirus (HPV) in Seminal Plasma And/or on Sperm in Men Undergoing Treatment With IVF/ICSI in Southwestern Sweden: A Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational study aims to investigate the presence of HPV DNA in semen samples from men undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment. It focuses on understanding the impact of HPV on male fertility and embryo development following IVF/ICSI. The primary goal is to determine the prevalence of HPV-positive (HPV+) semen samples among men seeking infertility treatment with IVF/ICSI. Additionally, … |
PANAGIOTIS TSIARTAS; | 2023-01-01 |
| 185 | An Investigation in The Use of Curcumin Topical Herbal Agent for The Treatment of Cervical Intraepithelial Neoplasia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to see if curcumin can suppress HPV infection in women with low-grade squamous intraepithelial lesions (LSIL) disease or treated high-grade squamous intraepithelial lesions (HSIL) disease. This study plans to explore the effect of curcumin as a potential medical treatment in HIV-uninfected and infected women with mild precancerous lesions of the cervix or recently treated high-grade precancerous lesions at risk for persistent HPV infection. About 200 women with low-grade precancerous lesions of the cervix or recently treated high-grade precancerous lesions will be enrolled to either insert 2000 mg of curcumin capsules in their vagina once a week or placebo after undergoing colposcopy or loop electrosurgical excision procedure (LEEP). They will have a repeat visit in 6 months where they will undergo a Pap smear and HPV test to determine if there are higher rates of HPV clearance after curcumin administration. If HPV is present or the Pap smear is abnormal, patients will then undergo colposcopic examination to evaluate cervical histology. |
LISA FLOWERS; | 2023-01-01 |
| 186 | Study of The Dynamics of Human Papillomavirus (HPV) Clearance in Post-treatment of High-grade Intraepithelial Lesions (HGIL) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years, studies have multiplied to demonstrate the value of performing an HPV test compared to a cervical smear test (CSP) in cervical cancer screening but also in the follow-up of surgical removal of high-grade intraepithelial lesions (HGILs). Thus, since June 2019, the High Health Authority recommends performing HPV genome testing by PCR for primary cervical cancer screening. Since September 2019, the National Cancer Institute recommends an HPV test in the follow-up of HGILs 6 months after conization. However, this delay was determined thanks to the previous recommendations which advocated a cervical smear test 6 months after conization. Thus, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-12-28 |
| 187 | HBV Vaccination of Healthy Volunteers to Evaluate The Composition of Germinal Centers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Antibodies are the primary mediators of the protection against infection provided by vaccination. Antibodies become most powerful after the B cells that produce them undergo an evolutionary process called affinity maturation, in which antibodies increase their ability to bind to their targets, and thus neutralize pathogens. Affinity maturation occurs in structures within secondary lymphoid organs (for example lymph nodes or tonsils) known as germinal centers. Germinal centers are well known to be triggered by the first dose of vaccines, generating affinity matured plasma cells (B cells that secrete antibody into serum) and memory B cells, … |
GABRIEL D. VICTORA; | 2022-12-10 |
| 188 | EarLy DEtection of CerVical CAncer in Hard-to-reach Populations of Women Through Portable and Point-of-care HPV TEsting Acceptability Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study includes a community-based, two-arm prospective acceptability study, whereby arm 1 consists of an educational session on sexual health and cervical cancer (screening) and a follow-up assessment after 3 months. Arm 2 consists of an educational session on sexual health and cervical cancer (screening) and self-sampling, additionally women will be asked to take a self-sample on-site, followed by a follow-up assessment after 3 months. Attitudes, uptake and users’ experiences related to the use of a HPV self-sampling test will be assessed, additionally, … |
BERNARDO VEGA CRESPO; | 2022-12-07 |
| 189 | A Non-controlled Trial to Determine Whether Counseling Around HPV Increases Vaccine Uptake in Unvaccinated Patients Ages 18-35 Visiting A Rural Health Clinic for Primary or Reproductive Health-related Care in The Mississippi Delta PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A study evaluating HPV vaccine uptake among unvaccinated patients between the ages of 18 and 35 of a mobile health clinic serving the Mississippi Delta. |
PLAN A HEALTH | 2022-12-06 |
| 190 | A Multicenter Cohort Study Assessing The Efficacy and Adverse Effects of Different HPV Vaccination in Chinese Women PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) is currently one of the most common sexually transmitted infections, according to its carcinogenicity is divided into high-risk genotypes and low-risk genotypes, research has confirmed that carcinogenic HPV type continuous infection leads to a higher incidence of condyloma acuminatum and cervical cancer, while increasing the oropharyngeal cancer, vaginal cancer and other related cancer risk. HPV vaccines have been widely introduced worldwide to prevent cancers of the lower genital tract such as cervical, anal and vulvar cancers. For different types of HPV vaccine, divided into domestic bivalent, imported bivalent (GlaxoSmithKline), quadrivalent (Merck) and nine-valent (Merck) HPV vaccine, … |
BINHUA DONG; | 2022-12-01 |
| 191 | The Community Nurse As A Public Health Determinant: A Quasi-experimental and Interventional Study of Promotion of Papillomavirus Vaccination in The School Population PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To date, there have been no interventional studies aimed at increasing HPV vaccination rates by making use of digital and involving all stakeholders within this process: nurses, physicians, caregivers, parents, and children/adolescents according to the PPI principle. The primary objective of the project is to identify the effectiveness of a digital educational intervention, conducted by a multidisciplinary healthcare team and targeting adolescents of both sexes in secondary schools. of the outcome measures will be: engagement, increased knowledge and self-efficacy, … |
PASQUALE STEFANIZZI; | 2022-12-01 |
| 192 | A Pilot Randomized Controlled Study to Examine Feasibility and Preliminary Effectiveness of Game-based Interventions in Promoting Vaccination Among Vulnerable Youth PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This proposed study aims to conduct timely research that promotes vaccine confidence and vaccination of two strongly recommended vaccines with suboptimal uptake rates: Human papillomavirus (HPV) and COVID-19 in vulnerable and underserved youth aged 11-14. |
ANGELA CHIA-CHEN CHEN; | 2022-12-01 |
| 193 | Improving Diagnostic in Cervical Dysplasia: A Randomized Study With Local Estrogen Prior to Colposcopy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is the fourth most common cancer in women worldwide. It is caused by an infection with human papillomavirus (HPV). A persistent infection with HPV is associated with increased risk of precancerous lesions, which may further develop into cervical cancer. To reduce the disease burden, accurate and timely diagnosis of cervical precancerous lesions are crucial. To identify cervical precancerous lesions, women are referred to colposcopy, which is the most important diagnostic tools to detect cervical precancerous lesions. It allows close visualization of the cervix in order to collect biopsies in the area called transformation zone (TZ), … |
MARIANNE ESBJERG; | 2022-12-01 |
| 194 | The Effect of Virtual Reality and Distraction Cards on Pain, Anxiety and Satisfaction Levels of Women Who Have Pap-Smears PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: When the literature is examined, it is seen that virtual reality and distraction cards are used during medical procedures, and they have a reducing effect on pain perception and lowering the level of anxiety . On the other hand, no study has been found in the literature on the application of virtual glasses and distraction cards to women in the PAP-SMEAR process. However, in accordance with the results of the study conducted with the application of virtual reality glasses and distraction cards, … |
MINE GOKDUMAN KELES; | 2022-12-01 |
| 195 | Prospective Observational Immunogenicity Trial of Gardasil-9 HPV Vaccine in People Living With Adequately Managed HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to determine the magnitude and breadth of the serum antibody response to the nonavalent HPV vaccine (Gardasil-9) in adults with well-controlled HIV infection. The secondary objectives of the study are to observe short term clinical outcomes of prevalent HPV genotype-specific anogenital infections in adults living with HIV who complete the three-dose Gardasil-9 vaccine series, … |
JENNIFER CAMERON; | 2022-11-30 |
| 196 | Prevention and Screening for Early Detection of HPV-related Cancers in Gay and Bisexual Men in Tanzania PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The long-term objective of the parent study is to reduce the effects of OPCa through secondary prevention (i.e., early detection, diagnosis and treatment referral). Consistent with this, this supplement will test HPV-related interventions tailored for Sexual Minority Men (SMM). Acceptability, feasibility and preliminary effectiveness of a smart-phone delivered Oropharyngeal Cancer (OPCA) self-assessment tool will be assessed. Given that homosexuality is stigmatized and criminalized in Tanzania, and that cell phone use is the key way SMM communicate in Tanzania, a self-assessment screening cell phone intervention holds particular promise for SMM in Tanzania but warrants separate evaluation. |
UNIVERSITY OF MINNESOTA | 2022-11-30 |
| 197 | Compare The Performance of The Pocket Colposcope to VIA/VILI for Triage of HPV+ Women in Kenya PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Pocket colposcope has 510k FDA clearance and has been successfully used in almost 1500 unique patients globally in Duke and non-Duke protocols to date. 400 women who are HPV-positive and planned to undergo treatment at 6 Ministry of Health-supported outpatient clinics in Kisumu County will be recruited to the study. After providing informed consent, participants will be randomized 1:1 to either standard-of-care visual inspection or colposcopy with the Pocket Colposcope |
MEGAN HUCHKO; | 2022-11-28 |
| 198 | Accelerating The Implementation of A Breast and Cervical Cancer Screening and HPV Vaccination Intervention for Under-served Hispanics PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study will develop and test an implementation strategy called Salud en Mis Manos-Dissemination and Implementation Assistance (SEMM-DIA) which is an internet-accessible cross-platform that includes additional implementation support strategies to increase the reach, effectiveness, and implementation of an evidence-based breast and cervical cancer screening and HPV vaccination program for Latinas (SEMM). |
LARA SAVAS; | 2022-11-16 |
| 199 | Validation and Feasibility of Patient Self-sampling of HPV for Cervical Cancer Screening PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to validate a patient self-sampling vaginal collection kit and laboratory testing for the detection of HPV (human papillomavirus) infection. Researchers will compare the laboratory results of self-collected vaginal swab samples to usual healthcare provider-collected cervical swab samples to determine the laboratory HPV testing accuracy of the self-collection swab. |
KATHY L. MACLAUGHLIN; | 2022-11-16 |
| 200 | Medical Assistance for Procreation Patient Library Targeting Patients With Idiopathic Infertility or Low Ovarian Reserve Before The Age of 35 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Creation of a patient library in Medically Assisted Procreation to allow the implementation of further research with the following objectives: * To identify new relevant biomarkers in patients who will carry a pregnancy to term * To better specify or identify new infertility risk factors * To identify new relevant biomarkers in patients with reduced ovarian reserve Four consultations are planned with biological et clinical collection. |
UNIVERSITY HOSPITAL BREST | 2022-11-11 |
| 201 | Assessing Personalized Vaginal Microbiome Contributions to HPV-driven Pre-malignant and Malignant Cervical Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and HPV presence in women with cervical pathologies (high-grade CIN and CC) and controls, to construct a large dataset from patients with pre-cancerous cervical lesions and healthy women, to evaluate the personalized contribution of the vaginal microbiome to the CIN-CC sequence. |
AHINOAM LEV-SAGIE; | 2022-11-09 |
| 202 | DEFLAGYN® Vaginal Gel and Spontaneous Remission and Regression of Unclear Cervical Smears and HPV High-risk Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomaviruses (HPV) are the most common sexually transmitted pathogens worldwide and in most cases are causally associated with the development of cervical cancer, one of the most common cancers in women and one of the leading causes of death in women worldwide. Precancerous lesions (dysplasias) or the presence of a high-risk HPV subtype are detected by a screening smear test performed by a gynecologist. If precancerous lesions are detected, conization (= surgical removal of a cone of tissue from the cervix) is the method of choice for removing the diseased tissue. However, … |
CLEMENS TEMPFER; | 2022-11-08 |
| 203 | An Educational Video’s Impact on Knowledge About HPV Vaccination and Cervical Cancer Screening Among Hispanic Patients: A Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The researchers will be conducting a prospective randomized trial where the researchers will be introducing an educational video to see whether there is an increase in knowledge scores surrounding cervical cancer, cervical cancer screening, and prevention with HPV vaccinations. |
STEPHANIE WANG; | 2022-11-01 |
| 204 | Prospective Assessment of HPV Associated Anogenital Pathology in Female Patients and Female Partners of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma (PAP-OP) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates how often women with throat (oropharyngeal) cancer or who have a partner with oropharyngeal cancer get anogenital infections with high risk, potentially cancer-causing types of human papilloma virus (HPV). |
KATHRYN M. VAN ABEL; | 2022-11-01 |
| 205 | The Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5-Flurouracil in The Treatment of Plantar Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the current work is to evaluate the efficacy and safety of intralesional combined Digoxin and furosemide versus intralesional 5-flurouracil in the treatment of plantar warts. |
NORHAN ANEES; | 2022-11-01 |
| 206 | In-vitro and Randomized Controlled Clinical Studying of Natural Constituents’ Anti-HPV Potential for Treatment of Plantar Warts Supported With in Silico Studies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Moringa banana nigella and Banna coat extract were prepared and formulated in the form of bi gel for transdermal delivery of these plant extracts. The formulation was prepared and charterized for organoleptic charters, morphology, and penetration efficacy. The optimised formulation was assessed clinically on patients suffering from plantar warts. The clinical study was phase 1 and interventional randomised allocation. |
SOAD ALI; | 2022-10-20 |
| 207 | The Effect of in Clinic or Self- Sampling for Cervical Cancer Screening on Status of Particitipation, Attitude and Anxiety PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Objective: The aim of this project was to determine the effect of clinic or self-sampling on attendance, attitudes, and anxiety in cervical cancer screening. |
OZGE SEN; | 2022-10-01 |
| 208 | Intralesional Vitamin D3 Versus Intralesional Acyclovir in Treatment of Plantar Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate and compare the efficacy and safety of intralesional acyclovir versus intralesional vitamin D3 in the treatment of plantar warts |
MAHA MOSTAFA ALI MOSTAFA; | 2022-10-01 |
| 209 | Evaluate The Safety and Immunogenicity of The 9-valent Human Papillomavirus Recombinant Vaccine (Hansenula Polymorpha) in Chinese Male Aged 9-45 Years: A Randomized, Blinded and Placebo-Controlled Phase I Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the safety and tolerability of the 9vHPV vaccine in Chinese healthy male aged 9 to 45 years. |
SHANGHAI BOVAX BIOTECHNOLOGY | 2022-09-23 |
| 210 | Evaluation of The Efficacy and Safety of The Local Treatment of Carboxymethyl Beta-glucan and Polycarbophil in Patients With Normal Cytology/ASCUS/LSIL (CIN1) With HPV+ PCR Determination PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective, Controlled, Multicentre, Real Clinical Practice Study. Effectiveness of Carboxymethyl β-Glucan treatment in high-risk HPV+ patients |
CARMEN PINGARRÓN SANTOFIMA; | 2022-09-22 |
| 211 | Evaluation of HPV Vaccine Immunity in High-risk Women: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single arm immunological study based in Vietnam. The study will examine human papillomavirus (HPV) vaccine responses in high-risk women (female-sex-worker; FSW). We aim to recruit 60 women (aged 18-25 years old) and provide them with a standard 3-dose schedule of licensed 4vHPV vaccine (Gardasil®, Merck). Blood and cervical swab samples will be collected for immunology and virology testing, respectively. |
MURDOCH CHILDRENS RESEARCH INSTITUTE | 2022-09-14 |
| 212 | A Pilot Study of Glutamine PET Imaging of Head and Neck Squamous Cell Carcinoma Related Papers Related Patents Related Grants Related Experts View Highlight: We propose a focused, prospective pilot clinical imaging trial to evaluate 11C-Gln PET/CT followed by 18F-FSPG PET/CT in 20 HNSCC patients. Imaging metrics that are common to PET (e.g. SUVmax, peak or mean) will be determined. This study will also allow the acquisition of additional safety and biodistribution data, as, to date, only a limited number of patients have been evaluated with 11C-Gln as a direct PET imaging biomarker of Gln uptake. To date, … |
LESLEY FLYNT; | 2022-09-14 |
| 213 | Design, Test and Evaluate Behavioural Insights Interventions to Strengthen Demand for Immunisation in Georgia PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: It is possible that achieving adequate HPV vaccination coverage will allow cervical cancer to be virtually eliminated. This is a priority for Georgia, where the burden of mortality and morbidity from cervical cancer is high and the yearly prevalence of cervical cancer is 14.5 per 100,000 population. The objective of the intervention evaluated is to increase the uptake of the 1st dose of the HPV vaccination in Georgia. The intervention aims to achieve this by providing a SMS reminder informed by behavioural insights (BI) to remind caregivers of girls between 10-12 years that their daughter is due the first dose of her HPV vaccination, share information about the vaccine, and encourage them to book an appointment to receive the vaccination. Four different SMS messages will be compared to no SMS message. The evaluation will be a 5-arm randomised controlled trial (RCT) which aims to answer the research question: Does each of the designed BI-informed SMS reminders increase the uptake of the first dose of the HPV vaccination among eligible girls in Georgia, compared to no reminder? Our hypothesis is that SMS reminders will increase the uptake of HPV vaccination. |
THE BEHAVIOURAL INSIGHTS TEAM | 2022-09-13 |
| 214 | A Non-Randomized, Open-Label Study to Assess The Reduction of Human Papillomavirus (HPV) Viral Infectivity and Transmission in HPV16/18-Positive Women After Vaccination With 9vHPV, A Multivalent L1 Virus-like Particle Vaccine, Evaluated in Cervical, Anal and Oral Samples Obtained After One, Two, and Three Vaccine Doses (RIFT-HPV1/RIFT-HPV2) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a non-randomized, open label study to assess the reduction of Human Papillomavirus (HPV) infectivity and transmission in women positive for HPV16 and/or 18 in a cervical, oral and anal sample and vaccinated with 9vHPV/Gardasil-9™. The primary objective of the study is to demonstrate that vaccination with a 3-dose regimen of 9vHPV will reduce viral infectivity in HPV 16/18/16+18-positive women. This objective rests upon the hypothesis that, since vaccination with 9vHPV triggers the production of type-specific HPV antibodies which are exudated to the cervical and other infected mucosae, … |
MIQUEL ANGEL PAVON RIBAS; | 2022-09-13 |
| 215 | Correlations Between Cervial Pap Smear,Vaginal Microbiota, Human Papillomavirus and Index of Blood Vitamins and Metabolic Markers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The human microbiome, comprising bacteria, fungi, and viruses, plays a crucial role in host physiology, immune function, and disease susceptibility. While gut microbiota have been extensively studied, other sites, including the vaginal microbiome, exhibit distinct microbial compositions. The vaginal microbiome is typically dominated by Lactobacillus species, which contribute to vaginal health but fluctuate with hormonal changes, menopause, and metabolic factors. This study analyzes the vaginal microbiome of 40 adult women using 16S rRNA sequencing and classifies them into Vaginal Community State Types (CSTs). CST IV, associated with dysbiosis, … |
CHENG HSIN GENERAL HOSPITAL | 2022-09-08 |
| 216 | Qualitative Study of HPV Self-Collection Experience and Cervical Cancer Screening in Patients With A History of Sexual Trauma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study explores the human papillomavirus (HPV) self-collection experience among individuals with a history of sexual trauma. Cervical cancer is the fourth most common cancer in women worldwide and is the second leading cause of cancer-related death in women ages 29-39. Despite programs to improve accessibility of cervical cancer screening and overall high screening rates, disparities in routine surveillance have been demonstrated in certain populations, such as victims of intimate partner violence and sexual trauma. One barrier to participating in cervical cancer screening for this population is the office-based visit which necessitates the individual to undress, … |
AMANDA BRUEGL; | 2022-09-06 |
| 217 | A Phase III, Randomized, Blinded, Positive-controlled Study to Compare The Immunogenicity of Zerun 9-valent Human Papillomarivus (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Recombinant Vaccine (Pichia Pastoris) in Healthy Female Subjects Aged 16-26 Years PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the immunogenicity and safety of Zerun 9-valent HPV recombinant vaccine in healthy female 16-26 years of age by comparing with GARDASIL®9. |
SHANGHAI ZERUN BIOTECHNOLOGY | 2022-09-01 |
| 218 | Immunogenicity of 9-valent HPV Vaccine in Immunocompromised Children and Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) causes the most prevalent sexually transmitted infections in the world. The nonavalent HPV vaccine (9vHPV) provides protection against 9 high-risk HPV serotypes, responsible for causing approximately 90% of cervical and other HPV-related anogenital cancers, as well as 90% of genital warts. The risk of cancer is substantially increased among immunocompromised patients. Although studies have demonstrated seroprotection among children and adolescents, boys and girls, with the 9vHPV vaccine, the immunogenicity of this vaccine has been poorly explored in immunocompromised children and adolescents (including transplant patients, and those infected with human immunodeficiency virus (HIV)). Several factors, … |
TALIA SAINZ COSTA; | 2022-09-01 |
| 219 | Proof of Concept and Feasibility in Podcasting Cervical Cancer Prevention for African American Women PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: For African American women (AAW) in Houston, cervical cancer mortality is disproportionate to their racial and ethnic counterparts.Most notably, lack of human papillomavirus (HPV) screening, vaccination, and later diagnosis increase cervical cancer mortality. However, cervical cancer is largely preventable. While previous research has identified only a few social determinants that are specifically related to cervical cancer, … |
CHAKEMA CARMACK; | 2022-09-01 |
| 220 | Pilot Study: Evaluation of A Novel Self-Collection Device for Cervical Cancer Screening PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluation of a novel self-collection device for cervical cancer screening. |
MEGAN FITZPATRICK; | 2022-08-28 |
| 221 | A Phase 1/2 Randomized, Observer-blinded, Multi-country Study to Evaluate Safety and Immunogenicity of Investigational Adjuvanted Human Papillomavirus Vaccine in Females (16 to 26 Years of Age) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study was to evaluate the safety and reactogenicity of GlaxoSmithKline Biologicals SA (GSK)’s investigational adjuvanted human papillomavirus (HPV) vaccine formulations. |
GLAXOSMITHKLINE | 2022-08-22 |
| 222 | Advancing Cervical Cancer Screening Through Self-Sampling (ACCESS): A Pilot Study of HPV Self-sampling for Cervical Cancer Prevention in Washington State PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate self-collection of vaginal samples for HPV testing as an alternative cervical cancer screening strategy for persons with HIV and/or limited access to care. Self-collection kits will be offered to persons who refuse a Pap smear or are overdue (>=6 months) for cervical cancer screening, with screening uptake recorded as a primary outcome. Kits will be offered in-clinic to individuals who refuse a Pap smear, … |
DARCY W RAO; | 2022-08-18 |
| 223 | RegoFlex EU/Real World Evidence on Stivarga Flexible Dosing in Patients With Metastatic Colorectal Cancer in Europe PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study in which data from patients with metastatic colorectal cancer in three European countries who received STIVARGA® (regorafenib), are collected. In observational studies, only observations are made without specified advice or interventions. Metastatic colorectal cancer (mCRC) is a cancer that starts in the large bowel or the rectum (the lowest part of the gut) and has spread to other parts of the body. Regorafenib is an anti-cancer drug that blocks several proteins called enzymes, … |
BAYER | 2022-08-15 |
| 224 | Community Health Outreach to Increase Cervical Cancer Education and Self-Collection Screening (CHOICESS) Program for Karenni and Hmong Women in Wisconsin PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to determine whether educational workshops paired with self-collected high-risk human papillomaviruses (hrHPV) screening will increase participation in cervical cancer screening among Hmong and Karenni refugee and immigrant populations in Wisconsin compared with offering clinician collected screening (total sample size: 250 participants). The investigators hypothesize that participation in cervical cancer screening will be higher among women in the intervention group as compared to the control group. |
JESSICA DALBY; | 2022-08-13 |
| 225 | Implementation of Circulating HPV DNA for The Screening and Surveillance of HPV-related Gynecologic Cancers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papilloma virus-related gynecologic malignancies affect over 20,000 women in the United States, and over half a million women globally each year. In addition, approximately 200,000 women are diagnosed with high-grade cervical dysplasia, a pre-cancerous tumor. There is no currently available serum biomarker for these tumors, and surveillance and diagnosis in these patients often requires invasive testing and procedures. The ability to diagnose and monitor for these cancers with a simple blood draw would have a significant impact both here in the US and abroad. In order to detect circulating tumor-specific HPV DNA, … |
ELENA PEREIRA; | 2022-08-10 |
| 226 | Using Peripheral Blood Circulating Tumor DNA (ctDNA) Based Human Papillomavirus (HPV) and Genetic Variant Test to Assess The Prognosis of Surgery or Radical Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational study is conducted to assess the value of using peripheral blood ctDNA to detect dynamic changes in HPV and genetic variants in predicting the prognosis of patients with locally advanced cervical cancer, as compared with traditional imaging and tumor markers. |
XIAOHUA WU; | 2022-08-10 |
| 227 | A Phase I/II Clinical Trail of TC-E202 Targeting HPV16 E6 for Relapsed/Refractory to Standard Treatment or Metastatic Cervical Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Cervical cancer is the most common gynecologic malignant tumor. The occurrence and progression of cervical carcinoma is firmly relevant to HPV (Human papilloma virus) infection. Cancer cells infected by HPV expressing an HPV protein called E6. E6 is the main factors of HPV 16 carcinogenesis. In TCR-T therapy, researchers take the blood of a certain patient, … |
TCRCURE BIOPHARMA | 2022-08-10 |
| 228 | Risk-Adapted Therapy for HIV-Associated Anal Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase II trial studies the side effects of chemotherapy and intensity modulated radiation therapy in treating patients with low-risk HIV-associated anal cancer, and nivolumab after standard of care chemotherapy and radiation therapy in treating patients with high-risk HIV-associated anal cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Chemotherapy drugs, such as mitomycin, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, … |
RAFI KABARRITI; | 2022-08-09 |
| 229 | Schoolbased HPV-counselling and -Vaccination, A User-centred Intervention Targeting Children and Parents With Ethnic Minority Background PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed as a non-randomized implementation study consisting of a user-centered school-based HPV-counselling and HPV-vaccination (HPVV) program. The aim is to improve HPVV coverage among children with ethnic minority background with minimum 10%-point in the intervention group. |
UNIVERSITY OF AARHUS | 2022-08-01 |
| 230 | Haemorrhage Risk Reduction Using Endovascular Embolisation in Place of Vessel Ligation for Patients Undergoing Transoral Robotic Surgery (HELPR) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Transoral robotic surgery (TORS )has been shown to offer excellent oncological and functional outcomes for treating cancer at multiple subsites of the head and neck. Post operative haemorrhage (3.1% to 13.1%) is the most common complication of this procedure and can lead to airway compromise. Ligation of individual feeding vessels in the neck can limit risk of severe bleed and is usually done when concomitant neck dissection is carried out with TORS. In salvage TORS, in the absence of any nodal disease of the neck, the neck is explored, nevertheless, … |
VINIDH PALERI; | 2022-08-01 |
| 231 | Evaluation of The Efficacy of Lactobacillus Crispatus M247 Administration in Promoting Clearance of Genital HR-HPV Infection and Modulating The Vaginal Microbiota: A Multicenter, Randomized, Placebo-Controlled, Single-Blind, Longitudinal, Prospective Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial evaluates the efficacy of the probiotic strain Lactobacillus crispatus M247 in promoting the clearance of genital high-risk human papillomavirus (HR-HPV) infection and restoring the balance of the vaginal microbiota. The study adopts a multicenter, randomized, single-blind, longitudinal, prospective design involving HR-HPV-positive patients. Primary outcomes include HR-HPV clearance rates and microbiota composition changes. |
AMJAD KHAN; | 2022-07-05 |
| 232 | Effect of Natural Compounds on The Severity of HPV-induced Cervical Lesions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To test the efficacy of a newly-commercialized formula, 40 HPV-positive women displaying chronic cervicitis, mild dysplasia or moderate dysplasia. Women in the study group took one tablet per day containing 200 mg of EGCG, 400 mcg of Folic Acid, 1 mg of Vitamin B12 and 50 mg of Hyaluronic Acid for twelve weeks. Women in the control group received no treatment. |
CESARE ARAGONA; | 2022-07-01 |
| 233 | In Situ/Microinvasive Adenocarcinoma of The Uterine Cervix and HPV-type Impact: Pathologic Features, Treatment Options, and Follow-up Outcomes – Cervical Adenocarcinoma Study Group (CAS-Group) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study will mainly aim to review and characterize the pathologic features, treatment options, and follow-up outcomes of women with in situ/microinvasive adenocarcinoma of the uterine cervix according to HPV status (positive versus negative high-risk HPV). It will evaluate the impact of HPV status on the recurrence and survival during a follow-up of five years. The present study will be a multi-institutional study including several oncological Italian Centers. Data will be retrospectively collected from January 2012 to December 2016 with a total follow-up of 5 years. |
LUCA GIANNELLA; | 2022-06-30 |
| 234 | Feasibility of A Multi-site Screening Strategy in HPV+ Patients at High Risk of Cancer, With Characterization of The HPV Subtypes Involved By High Throughput Sequencing Technique: DEP-HPV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main risk of developing cervical cancer is the persistence of an High risk human papillomavirus (HPV-HR) infection, the mechanisms of which are still not understood. These chronically infected patients could develop multi-site lesions. The main objective is to assess the feasibility of setting up a personalized screening in patients at high risk of cervical cancer (chronically infected with HPV), by evaluating documenting the acceptability of these patients to be sampled from the ENT sphere and anal spheres for HPV analysis with next-generation sequencing. |
ELODIE CHANTALAT; | 2022-06-21 |
| 235 | Immunogenicity of Fractional Dose of The HPV Vaccines PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized phase IV trial compares intramuscular and intradermal fractional dose of bivalent HPV vaccine to fractional dose of nonavalent HPV vaccine among men and women aged 27-45 years in Seattle, Washington. Participants will have immune response assessed at baseline, 4 weeks, 6 months, and 12 months |
ANNA WALD; | 2022-06-15 |
| 236 | Efficacy and Safety of Topical Methotrexate Gel 1% Coupled With Microneedling in Treatment of Warts : A Prospective Controlled Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To study the clinical efficacy of the topically applied MTX hydrogel preparation combined with microneedling to increase drug delivery and efficacy in comparison with cryotherapy in treatment of warts. |
KHULOOD FADHL AHMED ALHAKAMI; | 2022-06-15 |
| 237 | RBD-HPV: Risk-Based De-Intensification for HPV+ HNSCC Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to determine the rate of local regional control at 2 years when using de-intensified chemoradiotherapy (CRT) in patients with Human Papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC). Local regional control means no recurrence of the cancer in the head or neck area. Study subjects will be enrolled into 4 groups. Group/treatment will be based on a number of factors, including smoking and drinking history. |
MARSHALL POSNER; | 2022-06-14 |
| 238 | Human Papilloma Virus Genotypes and Treatment Outcomes of Intralesional Immunotherapy of Anogenital Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the relationship between HPV genotypes and treatment outcomes of intralesional immunotherapy of anogenital warts with the quadrivalent vaccine (Gardasil). |
RANA EHAB; | 2022-06-01 |
| 239 | A Longitudinal Cohort Study to Assess Effectiveness and B-memory Response to The Quadrivalent HPV Vaccine 9 Years Post-vaccination Among HIV-Infected Boys and Girls Ages 9-14 Years in Kenya PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The risk for Human Papillomavirus (HPV) infection persists through an individual sexual life and duration of protection is critical to vaccine effectiveness in protection from oncogenic hrHPV infection. HIV-infected individuals have an increased risk for HPV infection, and persistent infection. Most vaccine efficacy data among HIV-infected adolescents is represented by immunogenicity data, … |
NELLY MUGO; | 2022-05-25 |
| 240 | Impact of Human Papillomavirus (HPV) Vaccination on Burden of Disease in Patients With Actinic Keratosis – A Double-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A double-blind, randomized, placebo controlled intervention trial on patients with actinic keratosis. |
MERETE HAEDERSDAL; | 2022-05-09 |
| 241 | Closing The Gap Between Identification and Treatment of Cervical Abnormalities in Lima, Perú Through Integraton of Pocket Colposcopy, Telemedicine and Visual Counseling PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The Pocket colposcope has 510k FDA clearance and has been successfully used in almost 1500 unique patients globally in Duke and non-Duke protocols to date. The objective is to provide colposcopy capability to rural communities in Peru potentially using Telehealth. Approximately 10,000 women will receive self HPV test kit for community health workers. Of these participants, approximately 1,000 HPV+ participants will be invited to participate in this pocket colposcopy study. Approximately 500 of these participants may require treatment using thermocoagulation. |
NIMMI RAMANUJAM; | 2022-05-01 |
| 242 | Evaluation of Combined Treatment With Er:YAG Laser and Long-pulsed Nd:YAG Laser for The Treatment of Recalcitrant Warts: A Prospective Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Viral warts are common infectious skin disease induced by human papillomavirus (HPV). Lasers have been used for warts treatment in recent years with variable success rates. Objective: The goal of this clinical trial is to prospectively evaluate combined treatment with Er:YAG laser and long-pulsed Nd:YAG laser compared to Er:YAG laser for the treatment of recalcitrant warts after one session. The main question it aims to answer is: Does adding a treatment of long-pulsed Nd:YAG laser to Er:YAG laser in the same treatment session to the same wart have more curing effect than using the Er:YAG laser alone? This study included 240 lesions from 24 patients. All the lesions were diagnosed clinically as recalcitrant warts after failure of topical treatment and Cryotherapy. 120 lesions underwent a combined therapy of Er:YAG and long-pulsed (LP) Nd:YAG lasers, and the remaining 120 lesions underwent Er:YAG laser therapy only. The clearance rate was evaluated 5 weeks after and classified by three-graded evaluation: complete response, partial response, and poor response. Researchers will compare the 120 treated warts with the combined lasers therapy to the 120 treated warts treated with Er:YAG laser alone to see if adding the Nd:YAG laser therapy has an additional curing value. |
RAMBAM HEALTH CARE CAMPUS | 2022-05-01 |
| 243 | Human Papillomavirus Education Programs PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to implement a culturally-tailored educational outreach actives with the goal of increasing knowledge of human papillomavirus (HPV) types that can lead to cancer and uptake of the available vaccine. The initiative also addresses barriers to vaccination and refer people to sites where they can get the HPV vaccine (e.g., private doctor offices, community health clinics, school-based health centers, and health departments). The HPV education program may help increase HPV vaccination rates and ultimately prevent HPV-related cancers. |
ELECTRA PASKETT; | 2022-04-27 |
| 244 | The Evaluation of A Narrative Communication Intervention to Increase Human Papillomavirus Vaccination Intentions and Uptake in A Hispanic-Majority College Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The current study aims to evaluate a newly developed CSM narrative intervention in increasing HPV vaccination intentions and uptake in adults aged 18 to 26 years. The efficacy of the newly designed CSM-guided narrative video will be compared against a time and attention video and the standard of care print educational materials in increasing the intentions and uptake of the HPV vaccine in an adult Hispanic-majority college population. It is expected that participants receiving the CSM-guided narrative video will have greater HPV vaccine intentions compared with participants in the time and attention video and standard of care print education material groups. It is also hypothesized that participants receiving the CSM-guided narrative video will have greater HPV vaccine uptake at one month post-intervention compared with participants in the time and attention video and standard of care print education material groups. |
SARA FLESZAR; | 2022-04-20 |
| 245 | Feasibility and Acceptability of Implementing Integrated HPV Testing and Treatment of Pre-cancerous Cervical Cancer Lesions in Burkina Faso, Côte D’Ivoire, Guatemala, and The Philippines PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal is to assess the feasibility and acceptability of integrating into existing health systems, provision of HPV screening and treatment of pre-cancerous cervical cancer lesions with ablative treatments in Burkina Faso, Côte d’Ivoire, Guatemala, and the Philippines. Study findings will inform implementation of cervical cancer prevention and treatment services as part of a global effort to eliminate cervical cancer, with particular relevance for low-and-middle income countries. This will inform country strategy and guidelines on offering integrated cervical cancer prevention and treatment services in a manner that is culturally sensitive, client oriented, and system appropriate. |
MARK KABUE; | 2022-04-19 |
| 246 | Therapeutic Intralesional Nonavalent HPV Vaccine for Genital Condylomata in Adults: An Open Label Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will investigate whether injecting genital warts with small quantities of the Gardasil 9 vaccine has an effect on the warts. |
AYAN KUSARI; | 2022-04-15 |
| 247 | Fertility and The Microbiome: An Observational Study and Randomized Placebo Controlled Double-blind Pilot Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: With this study, the investigators want to investigate the microbiome and human papilloma virus (HPV) status of couples with subfertility. The investigators want to gain information about association of female and male microbiome and its impact on fertility. HPV prevalence is high, and its impact on fertility has not been studied intensively. The investigators want to find out whether there is an association between HPV status and subfertility, vaginal and seminal microbiome and HPV status and the prevalence among our subfertile couples. As part of this study, … |
MARTINA KOLLMANN; | 2022-04-11 |
| 248 | Intervention With Pea Protein Oral Nutrition Supplement Meal Replacement to Reduce Therapeutic Gastrostomy Tube Rates in Patients With Head and Neck Cancer Undergoing Chemoradiation Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase II trial studies the effect of a plant-based oral nutrition supplement, Kate Farms Standard 1.4 and/or Standard 1.0. as a primary source of nutrition in reducing the gastrostomy tube placement rate in patients with head and neck cancer that has spread to nearby tissue or lymph nodes (locally advanced) and who are undergoing chemoradiation therapy. Gastrostomy tube (G-tube) placement can be used for enteral feedings and may lead to long term side effects such as swallowing dysfunction and lead to higher rates of permanent G-tube dependence. The Kate Farms pea protein oral nutrition supplement is formulated with organic, … |
JIE DENG; | 2022-04-05 |
| 249 | Prévention Du Cancer Du Col De L’UTÉrus Par Dépistage D’Une Infection Partageable Sexuellement PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We propose a cross-sectional study to explore the acceptability and feasibility of HPV self-sampling among Quebec women. The study will invite eligible women to self-sample for HPV at home. The HPV risk factors of patients included in the study will be taken into consideration (vaccination, smoking, number of partners, date of last screening, etc.). |
JOSIANNE PARE; | 2022-04-04 |
| 250 | Candida Antigen and Bivalent HPV Vaccine in The Treatment of Multiple Warts: Monotherapy Versus Combined Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To follow up the efficacy and safety of Candida antigen, bivalent HPV vaccine in treatment of common warts either mono or combined intralesional therapy |
REHAM ESSAM; | 2022-04-03 |
| 251 | A Multi-site, Open-label Non-inferiority Trial to Assess Immunogenicity of Two Doses of The Nonavalent Human Papillomavirus (HPV) Vaccine Among Children, Adolescents and Young Adults (9-26 Years) Living With HIV Vs Three Doses of Nonavalent HPV Vaccine Among HIV Uninfected Young Women (15-26 Years) in Eswatini PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-site, open-label non-inferiority study of the 9vHPV vaccine among a population of children, adolescents and young women living with HIV in Eswatini. This protocol seeks to assess immunogenicity of a two-dose 9vHPV vaccine regimen among girls and boys (9-14 years) and young women (15-26 years) living with HIV on antiretroviral therapy versus a three-dose 9vHPV vaccine regimen among HIV uninfected young women (15-26 years) in Eswatini. The secondary objectives include examining the safety profiles of the two-dose 9vHPV regimen in those living with HIV and the three-dose 9vHPV regimen in HIV-uninfected young women, … |
ELAINE J. ABRAMS; | 2022-04-01 |
| 252 | Detection of High-Risk Human Papilloma Virus in Urine and Cervical Swab Specimens; Comparison Between HPV Diagnostic Kit (Bio Farma) and COBAS 6800 HPV (Roche Molecular Systems) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a cross-sectional study to evaluate accuracy of high-risk DNA-HPV testing using HPV Diagnostic Kit (Bio Farma) compared to Standard Kit (COBAS® 6800 HPV from Roche Molecular Systems) RT-PCR based in urine and cervical swab specimens. |
PT BIO FARMA | 2022-04-01 |
| 253 | The Mechanism of Vaginal Flora and Its Metabolites in The Pathogenesis of Cervical Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The disorder of vaginal microflora and its metabolites is considered to be a facilitating factor to human papillomavirus-mediated cervical cancer. However, the mechanism is still unclear. This study intends to carry out a cross-sectional study and a cohort study. The cross-sectional study intends to recruit 300 premenopausal non-pregnant women, dividing them into five groups, with 60 in each group: HPV negative [Ctrl HPV (-)], HPV positive [Ctrl HPV (+)], low-grade squamous Intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) and newly diagnosed invasive cervical cancer (ICC). Obtain basic information through the questionnaire, … |
SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY | 2022-04-01 |
| 254 | A Phase 3, Multicenter, Open-Label Study to Evaluate The Safety and Immunogenicity of 2-dose Regimens of 9vHPV and MRNA-1273 SARS-CoV-2 Vaccines Where The First Dose of Each Vaccine Are Given Concomitantly in Boys and Girls 9 to 11 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study to evaluate the safety and immunogenicity of a 2-dose regimen of 9vHPV vaccine, where the first dose is administered concomitantly with a first dose of a 2-dose regimen of mRNA-1273 vaccine versus nonconcomitant administration of 9vHPV and mRNA-1273 vaccines in boys and girls 9 to 11 years of age. |
MERCK SHARP & DOHME | 2022-03-28 |
| 255 | A Phase 1/2, First-in-Human, Multicenter, Open-Label Study of SQZ-eAPC-HPV As Monotherapy and in Combination With Immune Checkpoint Inhibitor(s) in Patients With HPV16+ Recurrent, Locally Advanced, or Metastatic Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1/2, first-in-human, open label, multicenter study to assess safety and tolerability, antitumor activity, and immunogenic and pharmacodynamic effects of SQZ-eAPC-HPV as monotherapy and in combination with pembrolizumab in patients with recurrent, locally advanced, or metastatic HPV16+ solid tumors. The study includes patients with head and neck, cervical, anal, vulvar, or penile cancer. |
MICHAEL GORDON; | 2022-03-24 |
| 256 | Phase II Trial Evaluating Selective Minimal Residual Disease Directed Adjuvant Radiation in Human Papilloma Virus Associated Oropharynx Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at whether monitoring HPV ctDNA levels is an effective way to detect cancer relapse risk in people with HPV-OPC. All participants will have recently had surgery to treat their disease, or they will be scheduled to have this surgery. In Arm A the researchers will see whether monitoring participants’ HPV ctDNA levels can safely identify patients who do not need radiation therapy (RT) after surgery and whose RT can be delayed until their HPV ctDNA levels become detectable. In Arm B, … |
LINDA CHEN; | 2022-03-24 |
| 257 | Assessing Knowledge, Beliefs and Attitudes Toward HPV Vaccination Among Parents With Children Aged 9-14yrs Within Rural Communities in North West Region, Cameroon PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess knowledge, beliefs and attitudes of parents to young girls aged 9 to 14 years about HPV vaccines within some rural communities in the North West Region of Cameroon served by three hospitals in that area. To do this, we will conduct in-depth qualitative interviews with purposively sampled parents of girls aged 9 to 14 years, some of whom received HPV vaccine and some of whom did not. Interviews will continue until thematic saturation is reached (We anticipate a total 40 interviews). Data analysis will be done concurrently with interviews using thematic analysis. |
LORRAINE ELIT; | 2022-03-14 |
| 258 | The Organ Transplant Recipient HPV and Skin Cancer Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Solid organ transplant recipients (OTRs) receive lifelong immunosuppressive therapy, which puts them at increased risk of cutaneous and mucosal cancers. In particular, OTRs have increased risk of skin cancer and cancers caused by human papillomavirus (HPV), including cervical cancer and oropharyngeal cancer. There is currently limited knowledge on risk factors for HPV infection and skin cancer in OTRs, and limited knowledge on the natural history of HPV infection and cervical neoplasia in OTRs compared with immunocompetent controls. With a continuously increasing number of OTRs, … |
MERETE HAEDERSDAL; | 2022-03-10 |
| 259 | Multicenter, Randomized, Open-Label Trial in Children and Adolescents to Establish Optimal Number of Doses for HPV Vaccination in Children and Adolescents Living With HIV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase IV trial compares 3 different dosing schedules to find the optimal number of doses for HPV vaccination in children and adolescents living with HIV. Comparing 3 different dosing schedules may help researchers determine whether a single dose of HPV vaccine could be effective in preventing HPV in children and adolescents living with HIV. |
ANN DUERR; | 2022-03-10 |
| 260 | A Randomised Controlled Trial Assessing The Efficacy of Strategies Involving Self-sampling to Reach Women Not Participating in Regular Cervical Cancer Screening PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The cervical cancer screening coverage remains moderate (60%) in France. The aim of the study is to evaluate the efficacy of two experimental invitation strategies (offer of urine or vaginal self-sampling kits) to reach under-screened populations and compare them with the current invitation strategy in rural departments (low medical density and low participation rate) in France. The study is a randomised controlled trial with three arms: a control arm (conventional invitation letter) and two experimental arms (mailing of a urine or vaginal self-sampling kit). The target population includes women aged 30-65 years, … |
CENTRE REGIONAL DE COORDINATION DES DEPISTAGES DES CANCER PAYS DE LA LOIRE | 2022-03-09 |
| 261 | Clinical Study of HPV Therapeutic DNA Vaccine (NWRD08) in Patients With Cervical HPV16 And/or HPV18 Positive PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label exploratory clinical study. The main objective is to explore the immunogenicity of HPV therapeutic DNA vaccine NWRD08. |
SUN GUODONG; | 2022-03-07 |
| 262 | Stimulating Immune Response With Neoadjuvant Human Papilloma Virus (HPV)-16 Specific Vaccination in HPV-Oropharyngeal Squamous Cell Carcinoma (HPV-OPSCC) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase I/II trial studies how well PDS0101 alone or in combination with pembrolizumab works to shrink tumor in patients with human papillomavirus-associated oropharynx cancer that has spread to nearby tissue or lymph nodes (locally advanced). PDS0101 is a vaccine made from specific peptides that may help the body build an effective immune response to kill tumor cells. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, … |
DAVID M ROUTMAN; | 2022-03-07 |
| 263 | Single-Dose HPV Vaccination Among Young Adult Women in Costa Rica: The PRISMA-ESCUDDO Trial (PRevencIón Del Cáncer Cervical Con Una Sola Dosis De Vacuna Contra VPH En Mujeres Adultas Jóvenes) PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase IV trial tests whether a single dose of the human papillomavirus (HPV) vaccine works in preventing cervical cancer in young women in Costa Rica. Human papilloma viruses, called HPV, are a group of viruses that very frequently cause infection in both men and women, mainly in the genital organs. There are many types of HPV, … |
AIMEE R KREIMER; | 2022-03-01 |
| 264 | Spectroscopy and Artificial Intelligence to Disrupt The Status Quo in Cervical Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer kills one woman every two minutes, 90% of these women are from low- and middle-income countries. Newly developed testing using biofluids has proven successful in identifying disease markers in, for example, brain cancers and endometrial cancers. Early studies have revealed that this technology is also showing potential for gynaecological cancers using validated human papillomavirus (HPV) test specimens. Urine samples, more easily collected, may make screening more accessible and acceptable to women. Spectroscopy is a portable and relatively simple technology; results are instant, … |
IWK HEALTH CENTRE | 2022-03-01 |
| 265 | A Social Media-based Machine Learning Study to Monitor Vaccine Confidence and Hesitancy and Early Warn Emerging Vaccine-related Risks in Real Time Related Papers Related Patents Related Grants Related Experts View Highlight: History and scientific evidence show that it is critical to maintain public trust and confidence in vaccination. Any crisis in confidence has the potential to cause significant disruption and a detrimental impact on vaccination. Vaccine hesitancy is a complex and context-specific issue that varies across time, place, and vaccines. It has been cited by World Health Organization(WHO) as one of the top ten threats to global health in 2019. Coronavirus disease(COVID-19) pandemic may change public confidence in vaccines. Therefore, it is necessary to establish a surveillance system to monitor vaccine confidence and hesitancy in real time. To date, … |
ZHIYUAN HOU; | 2022-03-01 |
| 266 | Phase II Study of AK104 (Cadonilimab) for Recurrent Small Cell Neuroendocrine Carcinomas of The Cervix PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 2, single center, open-label, single-arm study designed to evaluate the efficacy, safety, tolerability, and immunogenicity of AK104 monotherapy in adult subjects with previously treated recurrent or metastatic high grade neuroendocrine cervical cancer. |
MICHAEL FRUMOVITZ; | 2022-02-28 |
| 267 | SEARCH: Short Message Service (SMS) Electronic Adolescent Reminders for Completion of HPV Vaccination – Uganda: Pilot PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will take place at health centres and their affiliated schools and community immunization centers overseen by the Kampala Capital City Authority (KCCA) as well as at the Makerere/Mulago/Columbia Adolescent Health Clinic, also in Kampala. While text messages can be used in populations with low literacy, families can opt to receive automated phone call reminders instead. The investigators will pilot assess the impact of vaccine reminders on human papillomavirus (HPV) vaccination. Caregivers of preteens/adolescents will be randomized and stratified by site, language and HPV vaccine dose needed (initiation vs. completion). As this is a feasibility trial, … |
MELISSA STOCKWELL; | 2022-02-23 |
| 268 | Phase I, Proof of Concept, Open-Label, Randomized Clinical Trial to Evaluate The Safety and Effects of Using Prime-boost HIVIS DNA and MVA-CMDR Vaccine Regimens With or Without Toll-like Receptor 4 Agonist on HIV Reservoirs in Perinatally HIV Infected Children and Youth PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: HIVIS DNA and MVA-CMDR vaccines induce immune responses important for clearing infected cells: broad HIV-specific CD8+ cytotoxic T cells, potent antibodydependent cellular … |
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE | 2022-02-18 |
| 269 | Vaginal Microbiome and The Risk of Vulvovaginal Graft Versus Host Disease Following Hematopoietic Stem Cell Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Allogeneic stem cell transplantation (also termed bone marrow transplantation) involves transferring stem cells from a healthy person (the donor) to the patient, after high-intensity chemotherapy or radiation, given to destroy any remaining cancer cells in the body. When a transplant is successful, the donor stem cells replace the original cells in the bone marrow. It may provide the only long-term cure of the patient’s disease. Of transplant-related complications, graft-versus-host disease (GVHD) is one of the most important complications. GVHD arises from donor immune cells, … |
AHINOAM LEV SAGIE; | 2022-02-15 |
| 270 | Study MOTIF : MTOR Inhibitors: The Lesions Induced By Papillomavirus for Transplant Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The injuries induced by Human Papillomavirus (HPV) (anogenital condyloma mainly) are more frequent among transplanted patients due to their immunosuppression. These injuries are benign but they have a negative impact on the patients’ quality of life. The initial treatment is topical and then surgical. The injuries can relapse, especially among transplanted patients. The modification of the immunosuppressant treatment with a switch to mTOR inhibitors (mammalian Target Of Rapamycin) has shown its efficacy in preventing the recurrence of squamous cell carcinomas or treating Kaposi’s disease. By analogy, … |
FANNY BURON; | 2022-02-14 |
| 271 | The Role of Dentists in HPV Vaccination: Building The Infrastructure Between Co-located Dental Practices and Federally Qualified Health Centers to Facilitate HPV Vaccination Uptake PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This project involves the research into understanding the functioning of co-located/partnering dental practices and federally qualified health centers/community health clinics in North Carolina and how dental health providers may play a role in facilitating HPV vaccination uptake for under-vaccinated populations in these co-located/partnering sites. |
ESSIE TORRES; | 2022-02-01 |
| 272 | Clinical Triage and Treatment of Atypical Glandular Cells (AGC) Detected in Screening: Randomized Healthservices Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The risk of cervical cancer after diagnosis with atypical glandular cells (AGC) detected by screening is elevated for 15 years after discovery. The current recommendation is that when AGC is detected during screening, referel is made to a gynecologist for colposcopy with biopsy within 3 months after the index test. Repeated tests should be done after one year and after two years and if these are negative, the woman can return to routine screening. Given the increased risk of cancer associated with AGC a new evaluation of the optimal follow-up and treatment of AGC, which is detected during screening, … |
JOAKIM DILLNER; | 2022-01-27 |
| 273 | Cervical Cancer Screening: Evaluation of Telehealth to Enhance HPV Self-Collection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to compare the efficacy and participant experience of telehealth-based, self-collected cervical cancer screening to mail-based, self-collected cervical cancer screening across the adult female screening lifespan. This will be done by evaluating sufficient Human papillomavirus (HPV) sample collection and determining preference for self-collection verses provider collection, comparing role of telehealth in pre- and post- menopausal women’s comfort with self-collection, comparing self-collection completion rates for women with and without telehealth visits. |
AMANDA BRUEGL; | 2022-01-19 |
| 274 | Large Loop Excision of The Transformation Zone (LLETZ) With Versus Without Intraoperative Application of Lugol’s Iodine in Women With Cervical Dysplasia: A Prospective Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the gynecologist’s preventive smear test and can thus contribute to a 100% chance of cure if they are clarified by a colposcopic examination as part of the dysplasia consultation and, if necessary, … |
CLEMENS TEMPFER; | 2022-01-17 |
| 275 | Improving HPV Vaccination Delivery in Pediatric Primary Care: The STOP-HPV Trial 5. Single Arm Evaluation of The Bundle (Communication Skills, Performance Feedback and Prompts) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Most adolescents who receive human papillomavirus (HPV) vaccine are vaccinated in pediatric practices, yet missed opportunities (MOs) for HPV vaccination occur often and lead to low HPV vaccination rates. This single-arm study (embedded within arm 2 of a 2-arm cluster randomized clinical trial (RCT)) will test the effectiveness (and cost-effectiveness) of a bundled intervention (HPV vaccine communication, performance feedback reports and provider prompts), in practices that previously received standard of care, to reduce MOs and increase HPV vaccination rates. |
PETER G SZILAGYI; | 2022-01-12 |
| 276 | The Management of Radiotherapy-induced Hyposalivation Using Low-level Laser Therapy: A Case Series PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose is to evaluate the effectiveness of photobiomodulation laser application in the management of patients with radiotherapy-induced hyposalivation. Secondary, to assess the changes in the scores of the patient’s oral health-related quality of life using validated measurements. |
ABDULLAH MOHAMED ALSOGHIER; | 2022-01-03 |
| 277 | Impact of HPV Integration on The Prognosis of Women With Persistent HR-HPV Infection：a Multi-center Cohort Study in China PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinically, patients with persistent HR-HPV infection for more than 18 months or HR-HPV infection with CIN2 + need regular colposcopic biopsy to assess the outcome and progression of the disease. A total of 1000 participants with persistent HR-HPV infection (100 cases/center) were recruited from multiple centers, and HPV integration status and vaginal flora diversity were sequenced at baseline, 6th month, 12th month and 24th month, respectively, through prospective cohort studies. And to evaluate the influence of HPV integration status and flora changes on the prognosis of women with persistent HR-HPV infection. |
BINHUA DONG; | 2022-01-01 |
| 278 | Effect of HPV Integration on Prognosis of Young Women With CIN2 in China: A Multi-center Cohort Study in China PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinically, cervical precancerous lesion is one of the important diseases that endanger the life safety and fertility of young women. Women with histopathologically confirmed CIN2 need regular HPV, cervical cytology, and colposcopic biopsy if necessary to assess the outcome and progression of the disease. In this study, we intend to visit Fujian Maternal and Child Health Hospital, Ningde Mindong Hospital, Zhangzhou Hospital and other hospitals, including 500 CIN2 participants aged 35 and below diagnosed by histopathology, and collect the remaining cervical secretions and cervical exfoliated cell samples after clinical examination, … |
BINHUA DONG; | 2022-01-01 |
| 279 | Acceptability of Human Papillomavirus Self-sampling in Women Living With HIV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Women living with HIV are unsufficiently screened for cervix cancer although they have a higher risk of developping it, resulting of many obstacles. Offering a new screening technique, more accessible and which doesn’t require gynecologic examination, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2022-01-01 |
| 280 | The Effects of Probiotic Against Reducing Abundance of Human Papilloma Virus (HPV) in Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of oral administration of probiotic at 9 log colony forming unit (CFU)/day to reduce vaginal abundance of HPV in women compared to placebo via the use of vaginal self-swab. |
MIN-TZE LIONG; | 2021-12-27 |
| 281 | Assessing Immunological Basis of Durable Antibody Responses to 9-valent HPV Vaccination PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single center, longitudinal cohort study in which subjects will receive 9-valent HPV vaccine according to package insert (i.e., one dose of 9-valent HPV vaccine on day (D) 0 followed by a second dose 2 months later and a third dose 6 months later). Immune responses in the blood, saliva, bone marrow, and lymph nodes will be assessed in subjects receiving the HPV vaccine. Blood samples for immunologic testing will be collected at screening (from D-60 to D-45), on D0 (before vaccination), D1 (optional visit), D7, D14, D30, D60 (before vaccination), D61 (optional visit), D67, D74, D90, … |
ERIN SCHERER; | 2021-12-21 |
| 282 | Molecular Characterization of Penile Cancers in Developing Countries PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study explores penile squamous cell carcinoma (PSCC) in Brazil, a rare cancer associated with factors like poor hygiene and HPV infection, using next-generation sequencing to investigate its genomic profiles in 24 deceased patients with advanced PSCC. |
ANDRÉ POISL FAY; | 2021-12-17 |
| 283 | A Multicenter Cohort Study of HPV Viral Load in Predicting The Postoperative Recurrence of Women With HSIL in Cervix PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) infection has become one of the most important health problems faced by women all over the world. A large number of studies have shown that women’s cervical, vaginal and perianal precancerous lesions, related cancers, condyloma acuminatum and other sexually transmitted diseases (STD) are closely related to HPV infection. Among them, the persistent infection of high-risk human papillomavirus (HR-HPV) is closely related to the occurrence of invasive cervical cancer. Previous studies have shown that there are significant differences in the effects of multiple HPV infection and persistent infection of different types (such as type-16, -18, … |
BINHUA DONG; | 2021-12-15 |
| 284 | Hashtag HPV: Engaging Parents Through Social Media to Increase HPV Vaccination PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Parents use social media as an important parenting tool and source for health information. Using social media data to examine public opinion has had an early impact in public health and in cancer control and prevention efforts, including about the human papillomavirus (HPV) vaccine. A next step in this area of research is to develop and share messages on social media with parents to help inform and educate them about the HPV vaccine – ultimately assisting them with their decision to vaccinate their child. This study will evaluate the efficacy of social media messages through Twitter, … |
UNIVERSITY OF ARKANSAS FAYETTEVILLE | 2021-12-13 |
| 285 | Accurate Screening and Prevention of Cervical Lesions– Development of Accurate Screening Methods for Cervical Lesions PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare the accuracy and sensitivity of High-throughput human papilloma virus(HPV) typing and integrated assays with routine screening protocols (Cobas HPV test combined with thinprep cytologic test(TCT) for the detection of cervical intraepithelial neoplasia in the general and hospital populations. The main questions it aims to answer are: – High-throughput HPV typing and integrated assays can screen for ≥ cervical intraepithelial neoplasia (CIN2 or CIN3) with high sensitivity and accuracy. – … |
HUI WANG; | 2021-12-10 |
| 286 | Intervention for Human Papillomavirus Vaccine Acceptance in Mexican Mothers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Randomized clinical trial with two groups, with a test-retest model, with single-blind approach, using a probabilistic sampling and the population was mothers of girls aged 9 to 12 years from a public elementary school in the state of Puebla. The objective was to determine the effect of the intervention Vaccine for HPV Prevention aimed at the acceptance of the HPV vaccine in mothers of girls aged 9 to 12 years old in the urban area of the State of Puebla. |
GABRIELA IVETH MARTÍNEZ FIGUEROA; | 2021-12-07 |
| 287 | Towards A Better Paradigm for Head and Neck Cancer Treatment Applying Artificial Intelligence: An International Cohort Study of Electronic Health Records. HNC-TACTIC PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This will be an international, multicenter, retrospective, observational, and data-driven study using secondary data captured in EHRs. The extraction of the data captured in the EHRs will be performed with SAVANA’s EHRead®, an innovative data-driven system based on Natural Language Processing (NLP) and machine learning. For all patients, the Index Date is defined as the timepoint within the study period when they fulfill ALL inclusion criteria and no exclusion criteria. Follow-up comprises the period between Index Date and the last EHR available within the study period. Additional variable-specific time windows may be considered to optimize data collection. |
MIREN TABERNA; | 2021-12-06 |
| 288 | Prospective Observational Study Evaluating The Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Patients With Lymphopenia And/or Immunoglobulin E Elevation in Adult Immunology and Hematology Clinics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study was designed as an observational, prospective, epidemiological screening study. Patients who have been admitted to the center and whose lymphopenia and/or Immunoglobulin E elevation has been detected in at least one examination in their medical history will be included. In accordance with the relevant legislation, patients are required to accept and sign the Informed Consent Form regarding their participation in the study. Current data that the physician has already questioned in his daily practice will be collected from patients who have agreed to participate in the study, … |
TRPHARM | 2021-12-03 |
| 289 | Efficacy of Glycolic Acid 15%Plus Salicylic Acid 2% Gel in Treatment of Plane Wart PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To determine clinical efficacy of glycolic acid 15%plus salicylic acid 2% gel in treatment of Plane wart . |
ASSIUT UNIVERSITY | 2021-12-01 |
| 290 | Serum Galectin-3: A Potential Marker of Human Papillomavirus Infection Before and After Treatment of Cutaneous Warts PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to assess the serum Galectin-3 levels in patients with warts both before and after cryotherapy and to investigate its potential contribution to the pathogenesis of human papillomavirus infection. |
HEBA HASAN SAYED; | 2021-12-01 |
| 291 | Intervention Toward Knowledge of Human Papillomavirus in Homosexual Males PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intervention aimed at increasing knowledge of the human papillomavirus in homosexual men as a means of preventing sexually transmitted diseases and controlling complications associated with the pathology. |
JORGE ALBERTO MAYO ABARCA; | 2021-12-01 |
| 292 | Optimization of Screening Algorithms for Cervical and Anal High-Grade Squamous Intraepithelial Lesions in People Living With HIV in Mexico and Puerto Rico PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to find what different tests work best to find high-grade squamous intraepithelial lesions (HSIL) in the cervix or anus in patients living with human immunodeficiency virus (HIV). Patients with HIV are at high risk of becoming infected with human papillomavirus (HPV) in the cervix or anus where it can turn into cancer over several years. HPV causes changes to the cervix and anus, … |
JOEL PALEFSKY; | 2021-11-30 |
| 293 | Text and Talk: A Multi-level Intervention to Increase Provider HPV Vaccine Recommendation Effectiveness – Part 4: Randomized Controlled Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test the effectiveness of two interventions (parent-targeted text messages and a brief clinician-targeted training) at increasing HPV vaccination among 11- to 12-year-olds living in Florida. |
STEPHANIE STARAS; | 2021-11-18 |
| 294 | Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Most symptoms of human papillomaviruses (HPV) infection, do not cause serious health problems, but some do. As HPV can cause uncontrolled growth of infected cells, some people can develop benign skin lesions, larger warts, genital lesions, tumors or cysts that do not respond to treatment. Researchers want to learn why. Objective: To better understand why some people are more likely than others to get sick from HPV infection, … |
ANDREA LISCO; | 2021-11-17 |
| 295 | Impact of A School- and Primary Care-based Multicomponent Intervention on HPV Vaccination Acceptability Among French Adolescents: A Cluster Randomized Controlled Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims at evaluating the effectiveness, efficiency and implementation of a multicomponent intervention (components being applied in combination or alone) on the acceptability of HPV vaccine among French adolescents (11-14 years old) through a cluster randomized controlled trial. The primary outcome to measure acceptability is vaccine coverage. The three components are: adolescents and parents’ education and motivation at school (component 1); general practitioners’ training (component 2); and access to vaccination at school (component 3). Ninety municipalities are included and randomized into six groups of 15 municipalities, according an incomplete factorial plan. |
NATHALIE THILLY; | 2021-11-15 |
| 296 | Adjuvant Imiquimod Therapy to Reduce Recurrence Rate in Patients After Surgical Therapy of Anal HPV (Human Papilloma Virus)-Lesions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: AdAM is a prospective, randomized, controlled, double-blinded, monocentric trial in patients receiving surgical therapy due to anal HPV infection. Aim of the study is to evaluate efficacy of combination therapy (surgical therapy + topical Imiquimod-therapy). It is planned to include 200 patients. 100 patients receive surgical therapy+ topical Imiquimod therapy, 100 patients receive surgical therapy + topical Placebo therapy |
IRMGARD E KRONBERGER; | 2021-11-15 |
| 297 | Hyperbaric Oxygen Therapy for Long COVID Patients With Pulmonary Sequela – Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot study in 24 subjects where half will be randomized to 10 treatments with hyperbaric oxygen (HBO). It will primarily study pulmonary sequelae with imaging and physiological measurements (low dose chest computer tomography (CT), Ventilation/perfusion with magnetic resonance imaging (VA/Q MRI), cardiopulmonary exercise testing with pulse oximetry (SpO2) and spirometry including diffusion capacity for carbon monoxide (DLCO). The target patient group will be previously healthy whom have had covid-19 with lingering symptoms past 12 weeks of recovery from the acute phase. |
PETER LINDHOLM; | 2021-11-08 |
| 298 | Early Detection of Vulval CAncer Through Self-Examination (EDuCATE): Intervention Study A Feasibility Study of Interventions to Promote Vulval Self-examination in Women at Increased Risk of Vulval Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Vulval cancer, while rare, has increased in incidence by 17% since the 1990s. It is strongly associated with age, thus this increasing trend is likely to continue with extended life expectancy. Vulval cancer is highly treatable when detected early. Women with chronic vulval conditions including lichen sclerosus, lichen planus and vulval intraepithelial neoplasia are at increased risk of developing vulval cancer. Most patients are in hospital follow-up, … |
VANITHA SIVALINGAM; | 2021-11-04 |
| 299 | Long-Term Human Papillomavirus Vaccination Effectiveness and Immunity in Rwandan Women Living With and Without Human Immunodeficiency Virus PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study will assess and measure population effectiveness of prophylactic HPV vaccine in reducing cervical, anal, and/or oral prevalent and 6-month persistent infections among HPV-vaccinated and 757 HPV-unvaccinated Rwandan WLWH aged 18-26 years. Additional objectives include the quantification & examination of long-term antibody (into young adulthood) responses to HPV vaccination and to validate the performance (e.g., sensitivity and specificity) of a low-cost, POC (point-of-care) anti-HPV16 antibody test to determine/confirm HPV vaccination status. The findings for this study will provide necessary evidence regarding the long-term protection afforded by HPV vaccination in WLWH living in SSA, … |
KATHRYN A ANASTOS; | 2021-11-03 |
| 300 | Study on The Immunogenicity and Safety of Co-immunization With Recombinant Human Papillomavirus 16/18 Bivalent Vaccine and Hepatitis E Vaccine PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the immunogenicity and safety of co-immunization with recombinant human papillomavirus bivalent (Types 16,18) vaccine (Escherichia coli) and Hepatitis E vaccine (Escherichia coli) |
ZHENGGANG JIANG; | 2021-10-25 |
| 301 | Urinary and Vaginal HPV Testing As A Novel Cervical Cancer Screening Tool: A Diagnostic Test Accuracy Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer, caused by high-risk human papillomavirus (HPV) infection, poses a problem worldwide as it is the fourth most common female cancer. Fifty percent of all invasive cervical cancers occur among the 25% not attending cervical cancer screening. To reach these women, this project will contribute to the development of a novel and accurate urinary and vaginal screening tool, which allows women to collect the screening samples at home. This project tests the hypotheses: 1) urinary HPV testing is non-inferior to HPV testing on clinician-collected cervical samples for detection of high-grade cervical pre-cancer, … |
METTE TRANBERG NIELSEN; | 2021-10-18 |
| 302 | Comparative Study Between Intralesional Injection of Autologous Plasma Rich Platelets Versus Candida Antigen in Patients With Plane Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the efficacy of intralesional injection of autologous plasma rich platelets and candida antigen in treatment of patients with plane warts . |
RANDA ABD AL-NASER HUSSIEN KAMEL; | 2021-10-15 |
| 303 | A Phase II Study of Duvelisib Plus Docetaxel in PD-1 Inhibitor Experienced Patients With Incurable Head and Neck Squamous Cell Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial that is investigating a medication called duvelisib in combination with docetaxel for the treatment of squamous cell carcinoma of the head and neck (SCCHN) that has returned or spread outside the head and neck area. The names of the study drugs involved in this study are: * Duvelisib (PI3K inhibitor) * Docetaxel chemotherapy |
GLENN J. HANNA; | 2021-10-14 |
| 304 | A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Often, metastatic human papillomavirus (HPV) associated cancers cannot be cured. They also do not respond well to treatment. Some forms of colon cancer also have poor responses to treatment. Researchers want to see if a new drug treatment can help people with these types of cancers. Objective: To find a safe dose of entinostat in combination with PDS01ADC and bintrafusp alfa and to see if this treatment will cause tumors to shrink. Eligibility: Adults ages 18 and older who have cervical, oropharyngeal, anal, vulvar, vaginal, penile, squamous cell rectal, … |
HOYOUNG M MAENG; | 2021-10-05 |
| 305 | Maximizing HPV Vaccination: Real-time Reminders, Guidance, and Recommendations – Part 4: Feasibility Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) vaccines have potential to prevent an average of 26,900 cancer cases each year in the United States, but vaccine coverage rates remain low. The study team has developed an electronic application (app), Protect Me 4, to help parents and providers assess and have more productive conversations about needed vaccines. The specific aims of this study are to: (1) evaluate the feasibility of implementing Protect Me 4, and (2) estimate preliminary efficacy of Protect Me 4 to increase HPV vaccine initiation (receipt of first dose). |
STEPHANIE STARAS; | 2021-10-01 |
| 306 | Strategies for Endocervical Canal Investigation in Women With Abnormal Screening Cytology (ASC-H+) and Negative Colposcopy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: cervical cancer is the fourth most frequent cancer in women worldwide and in Brazil, it occupies the third position for the triennium 2020/2022, with a high mortality rate and maintained in the last 10 years. It is associated with persistent human papillomavirus (HPV) infection. Primary prevention can be accomplished through vaccines that prevent HPV infection of the epithelial cells of the cervix. Secondary prevention in screening for precursor lesions through periodic repeat cervical sampling in a population of asymptomatic women. Women with abnormal cytology are more likely to have pre-invasive or invasive lesions and are referred for further testing, … |
CIRBIA SILVA CAMPOS TEIXEIRA; | 2021-09-29 |
| 307 | Immunogenicity Non-inferiority Immuno-bridging Study of A Recombinant Human Papillomavirus Nonavalent (Types 6,11,16,18,31,33,45,52,58) Vaccine (E.Coli) in Healthy Population Aged 9-17 Years Old Vs Aged 18-26 Years Old PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a open label clinical trial to evaluate the safety and immunogenicity of a Recombinant Human Papillomavirus Nonavalent (Types 6,11,16,18,31,33,45,52,58)Vaccine(E.Coli) manufactured by Xiamen Innovax Biotech CO., Ltd., in healthy population aged 9-17 years old in comparison with aged 18-26. |
JUN ZHANG; | 2021-09-19 |
| 308 | Protective Efficacy of HPV Vaccination After Treatment of HPV Related Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To understand the HPV infection status and subtype distribution of patients, and to study the protective effect of prophylactic HPV vaccination on the recurrence of HPV related diseases after treatment through a prospective cohort study. To provide data support for the primary prevention of HPV related diseases in Chinese women after treatment, and to analyze the related factors of HPV related disease recurrence and HPV continuous positive. |
XIJING HOSPITAL | 2021-09-18 |
| 309 | Oropharynx (OPX) Salivary Biomarker Study: Microbiome, Virome, and Metabolomics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to analyze certain biomarkers to look at the relationship between HPV in the saliva, stage at presentation, and a potential self-test compared to saliva of non-cancerous participants. |
KATHRYN (KATIE) M. VAN ABEL; | 2021-09-17 |
| 310 | Benefit From A Proximity-incentive Strategy Based on Vaginal Self-sampling for Women Who Do Not Participate to Cervical Cancer Screening in Aude and Hérault [French Departments]: An Interventional Research to Reduce Social and Territorial Inequalities PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In France, cervical cancer screening is based on a cervical smear for women aged 25 to 30 years and on High Risk- HPV (HR-HPV) testing for women aged 30 to 65 years. One of the main concerns in France is poor attendance to this screening program, up to 40% of women, which led French Health Authorities to implement population-based organized cervical cancer screening (DO CCU), based on remind letters, … |
NATHALIE BOULLE; | 2021-09-16 |
| 311 | Clinical Evaluation Study of Urine HrHPV Detection for The Diagnosis of Presence of Cervical HPV and Correlation of Cervical Lesions PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is one of the most common tumors in women, which seriously threatens women’s life quality and safety. Human papilloma virus (HPV) infection is the most common cause of cervical cancer. Traditional HPV testing is based on the cells sample shed from the cervix. Recent studies have shown that urine HPV detection can be used as a new HPV detection method. This study intends to include patients undergoing TCT /HPV test/colposcopy in the department of gynecological diseases of the hospital, … |
WANG JIANLIU; | 2021-09-15 |
| 312 | The Effect of HPV Training on Early Diagnosis Screening and Knowledge Levels of Female Teachers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to determine the effect of health education given to female teachers on HPV knowledge and screening test. The population of the study consisted of all female teachers belonging to the Bucak Directorate of National Education between September 2021 and March 2022. The sample of the study consisted of 144 healthy female teachers who were registered in the institutions affiliated to the District Directorate of National Education between the specified dates, met the inclusion criteria and volunteered to participate in the study. In this study area, … |
NURTEN TERKES; | 2021-09-15 |
| 313 | Evaluation of An Human Papillomavirus (HPV) Based Screening Algorithm for Low and Middle Income Countries, By Self-sampling in Ethiopia PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall purpose of the project is to evaluate an algorithm for an HPV self-sampling based cervical cancer screening algorithm in a mid-size town in Ethiopia that could be applicable for nationwide implementation in low and middle-income countries (LMIC). Specific aims are the following: – To evaluate the algorithm using Visual Inspection with Acetic acid (VIA) and VIA together with Lugol’s Iodine (VILI) as triage and to use HPV self-sample to follow up those treated and those with persisting HPV. – To evaluate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae and their effect on the quality of VIA. – … |
ADANE MIHRET; | 2021-09-06 |
| 314 | Cervical Cancer Screening with NGS-HPV Technology Based on Menstrual Blood PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study is a population-based, cross-sectional study. This study is conducted to recruit cervical cancer screening participants to evaluate the application value of using high-throughput sequencing technology to detect HPV in menstrual blood for cervical cancer screening. Our study is designed as a two-phase study : Phase I : This phase, which will be preparing to recruit 5,000 participants, evaluates the accuracy of menstrual blood (MB) self-sampling for detecting cervical intraepithelial neoplasia grade two or worse (CIN2+) in the general population, … |
ZHENG HU; | 2021-09-01 |
| 315 | Comparison of The Hologic Genius Digital Diagnostics System With The Liquid-based Cytology (LBC) Manual Microscopic Approach PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Quality assurance of the laboratory examinations. Prospective non-interventional study with ThinPrep slides collected during the German Co-Screening Program and routinely sent to the lab to prospectively evaluate the clinical performance of the Hologic Genius Digital Cytology (DC) system vs. the liquid-based cytology (LBC) manual microscopic approach |
HOLOGIC DEUTSCHLAND | 2021-09-01 |
| 316 | A Multicenter Cohort Study of HPV Viral Load in Predicting The Prognosis of Women With LSIL in Cervix PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) infection has become one of the most important health problems faced by women all over the world. A large number of studies have shown that women’s cervical, vaginal and perianal precancerous lesions, related cancers, condyloma acuminatum and other sexually transmitted diseases (STD) are closely related to HPV infection. Among them, the persistent infection of high-risk human papillomavirus (HR-HPV) is closely related to the occurrence of invasive cervical cancer. Previous studies have shown that there are significant differences in the effects of multiple HPV infection and persistent infection of different types (such as type-16, -18, … |
BINHUA DONG; | 2021-09-01 |
| 317 | PAPILOBS GR: A Clinical Investigation to Assess The Effectiveness of PAPILOCARE® in The Regression of Cervix Cytological Abnormalities Caused By HPV PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study is a multicenter, open, non-interventional, prospective observational clinical study for the evaluation of the effectiveness of Papilocare® (medical device with CE mark) in the regression of cervix cytological abnormalities caused by HPV. |
ELPEN PHARMACEUTICAL | 2021-09-01 |
| 318 | Randomized Clinical Trial of Tele-Surveillance and Remote Symptom Monitoring Compared to Standard Surveillance for HPV-Associated Oropharynx Cancer With No Evidence of Disease on Post-Treatment Imaging PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to compare standard surveillance with telemedicine surveillance (tele-surveillance) and find out which surveillance approach is best for people with HPV-associated head and neck cancer who have no evidence of disease after treatment. The researches will look at how the two approaches affect participants’ quality of life, health outcomes, and expenses (for example, costs of routine visits and procedures). They will also determine doctors’ and patients’ satisfaction with tele-surveillance. |
KAVEH ZAKERI; | 2021-09-01 |
| 319 | Increasing Human Papillomavirus Vaccination in Postpartum Women at Penn State Hershey Medical Center Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the acceptability of HPV vaccination in postpartum women in Central Pennsylvania. Participants will be recruited while inpatient in the postpartum unit. Participants will complete a survey asking about knowledge, attitudes, and beliefs around vaccination, including HPV vaccination, as well as breastfeeding intentions. After survey completion, the participant will have the option to receive the HPV vaccine, Gardasil 9, prior to discharge from the hospital. All participants will then be contacted 1- week later for the follow-up survey. |
STACEY MILUNIC; | 2021-09-01 |
| 320 | A Tailored School-based Intervention to INcrease VaccinE Uptake Among AdoleScenTs (INVEST) in The Rural South PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The benefits of adolescent vaccines are well known for preventing meningococcal infection and human papillomavirus (HPV)-related pre-cancerous lesions. Yet, many adolescents in the United States (US) remain under-vaccinated, with vaccination rates among rural adolescents significantly lower than among their urban peers. In addition, there are urban-rural disparities in the coverage of HPV vaccine, particularly in Southern states like North and South Carolina, … |
EMMANUEL WALTER; | 2021-08-31 |
| 321 | A Multilevel HPV Self-Testing Intervention to Increase Cervical Cancer Screening Among Women in Appalachia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial studies how well a multilevel human papillomavirus (HPV) self-testing intervention works in increasing cervical cancer screening among women in Appalachia. Most cases of cervical cancer occur among unscreened and underscreened women. A multilevel HPV self-testing intervention may help to improve cervical cancer screening rates. |
PAUL REITER; | 2021-08-27 |
| 322 | Immunogenicity and Safety of Concomitant Inoculation of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine (Escherichia Coli) and Measles Mumps and Rubella Combined Vaccine, Live PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the immunogenicity and safety of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine (Escherichia coli) （HPV）and Measles Mumps and Rubella Combined Vaccine, Live（MMR） |
ZHEJIANG PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION | 2021-08-25 |
| 323 | Comparison of The Hologic Genius Digital Diagnostics System With The ThinPrep Imaging System – A Retrospective Assessment PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Quality assurance of the laboratory examinations. Retrospective non-interventional study with ThinPrep slides collected as part of the German Co-Screening Program for routine diagnostic. These slides will retrospectively be used to validate the Hologic Genius Digital Cytology (DC) system vs. the ThinPrep Imaging system (TIS). |
HOLOGIC DEUTSCHLAND | 2021-08-20 |
| 324 | A Phase 1, Multicenter, Open-Label Study of SQZ-AAC-HPV As Monotherapy and in Combination With Immune Checkpoint Inhibitors in HLA-A*02+ Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1 open-label, multicenter study of the safety and tolerability, immunogenic effects, antitumor activity, and pharmacodynamics of SQZ-AAC-HPV as monotherapy and in combination with immune checkpoint inhibitors in HLA-A*02+ patients with recurrent, locally advanced or metastatic human papillomavirus strain 16 positive (HPV16+) solid tumors. The study includes patients with anal, rectal, cervical, head and neck, penile, vulvar, or vaginal cancer. |
VICTORIA M VILLAFLOR; | 2021-08-19 |
| 325 | Prospective Observational Study Evaluating The Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis in Pulmonology Clinics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational study was designed as a prospective epidemiological screening study. Patients who have applied to the centers participating in the study and who have previously been clinically or pathologically diagnosed with PAP (Pulmonary alveolar proteinosis) will be included in the study. Up-to-date data will be collected from patients who have agreed to participate in the study, and a blood sample with DBS will be taken from patients. The blood taken will be subjected to analysis for ADA metabolites. For patients with a high metabolic test, … |
TRPHARM | 2021-08-16 |
| 326 | Understanding and Addressing The Disparity in Vaccination Coverage Among U.S. Adolescents Living in Rural Versus Urban Areas PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Vaccine uptake in the United States is lower in rural areas, especially for HPV vaccine. Reminder/recall has been identified as an effective strategy to increase vaccination rates. This study will assess the impact by rurality of vaccine reminder notices sent via the parent’s preferred method of communication on HPV vaccination among 12 year-old patients in a regional healthcare system. |
HUONG MCLEAN; | 2021-08-12 |
| 327 | THE HONG KONG ORAL CANCER EDUCATION AND SCREENING (HOCES) PROGRAM: REFINING DISEASE PREVENTION, RISK STRATIFICATION AND EARLY DETECTION PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and low-risk oral lesions. Likewise, this study will seek to provide oral cancer-related health education and training on oral-self-examination for beneficiaries |
PETER JAMES THOMSON; | 2021-08-01 |
| 328 | Effectiveness of The QHPV Among Kenyan HIV Infected Girls and Boys 9 Years Post Vaccination PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In 2013, the Investigators enrolled a cohort of 180 HIV-1 infected adolescent girls and boys ages 9-14 years and administered three doses of the QHPV vaccine (NCT04711265). For this study, the Investigators shall evaluate vaccine effectiveness 9 years post first vaccination. Participants will be evaluated for HPV type specific antibody, genital HPV infection, genital warts and a subset of 30 participants will be evaluated for memory B and T cell responses. |
NELLY RWAMBA MUGO; | 2021-08-01 |
| 329 | A Phase 0 Trial of HB-201 for Subjects With Transoral Resectable Human Papillomavirus 16 Positive (HPV 16+) Oropharynx Cancer or With Locally Advanced Cervical Cancer Treated With Chemotherapy and Radiation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Window Of Opportunity clinical trial will examine the immunologic effects of the study agent HB-201 in the head and neck or cervical cancer, when administered either by IT injection or by IV route. |
STUART J WONG; | 2021-07-28 |
| 330 | Improving Cervical Cancer Screening in Women Living With HIV Attending Chronic Disease Clinics in Semi-rural Tanzania PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to analyse the effect of a bundle of measures on the proportion of females being screened for cervical cancer in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO), comparing the time period before implementation (01/2017-01/2020) and after implementation (02/2020-06/2022). It is to assess the performance of two novel diagnostic tests (QuantiGene-molecular profiling histology (QG-MPH) and PT Monitor® immunoassay) and established tests (Seegene Anyplex™ II 28 HPV Test and Prevo-check®) as potential triage tests for the development of future clinical decision algorithms for CC screening. |
IVANA DI SALVO; | 2021-07-27 |
| 331 | Adaptation of An HPV Education Resource to Promote HPV Vaccination Among Latino Young Men Who Have Sex With Men in Puerto Rico and Florida — Proyecto Hombres Previniendo El VPH (Proyecto HPV) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to assess Human Papillomavirus (HPV) and HPV vaccination knowledge, awareness, attitudes, health beliefs, and behaviors as well as educational preferences for learning more about HPV and HPV vaccination and to receive feedback on and adapt HPV educational materials for Young Latino Men who have Sex with Men (YLMSM). |
SHANNON M CHRISTY; | 2021-07-23 |
| 332 | Screening for Human Papillomavirus and Cervical Cancer in Young Women With Perinatally Acquired HIV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a cross-sectional, observational study of high-risk HPV status, cervical cytology and HPV vaccine uptake and response in young women with perinatally acquired HIV. |
IMPERIAL COLLEGE LONDON | 2021-07-19 |
| 333 | Characteristics of Vaginal and Intestinal Microbiota in Women With Different Cervical HPV Infection PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: There are different microbial communities on the surface of human body (skin, hair, nails, etc.) and in the cavity connected with the outside world. The human microbiota is the general term of the genetic information of microorganisms that coexist with human beings and cause various diseases under certain conditions. The results of human microbial genome analysis show that the microbial communities in different parts of the human body and different individuals have amazing diversity, some of which play an important role in human health, … |
BINHUA DONG; | 2021-07-01 |
| 334 | Immunotherapy Combined With Neoadjuvant Chemotherapy in Patients With Locally Advanced HPV (-) Head and Neck Squamous Cell Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: There are few clinical trials of chemotherapy combined with immunotherapy in the neoadjuvant stage of locally advanced head and neck squamous cell carcinoma. The phase II clinical trial of efficacy and safety of immunotherapy combined with neoadjuvant chemotherapy in patients with locally advanced HPV (-) head and neck squamous cell carcinoma carried out by our team will be an active exploration of the application of immunodrugs in the neoadjuvant stage of newly treated patients with locally advanced head and neck squamous cell carcinoma |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2021-07-01 |
| 335 | A Phase II Open-Label, Single Arm Pilot Study to Evaluate The Safety and Efficacy of Pembrolizumab for High-Grade Cervical Intraepithelial Neoplasia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase II trial studies the effect of pembrolizumab on cervical intraepithelial neoplasia. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. |
JOHN A GLASPY; | 2021-06-30 |
| 336 | Prevalence and Longitudinal Follow-up Over 2 Years of Anal Lesions, HPV Infection and Associated Sexually Transmitted Infections Among Men Who Have Sex With Men (MSM) in Lomé, Togo PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The DepIST-H study, funded by the French AIDS and Hepatitis Research Agency (ANRS), is to estimate prevalence (the number of cases over a given period of time) and incidence (the number of new cases over a given period of time) of anal lesions (condylomas, dysplasia, cancers) by HIV status among MSM in Lomé, Togo |
CHARLOTTE CHARPENTIER; | 2021-06-24 |
| 337 | The OPTIMIZE Study: Optimizing Patient Navigation for Perinatal Care PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will develop and test an intervention, called OPTIMIZE, which includes the use of a perinatal checklist by clinic staff and provision of patient navigation support to African American pregnant women. Half of the clinics in the study will be assigned to the OPTIMIZE intervention and half will administer standard care. |
MELISSA SIMON; | 2021-06-23 |
| 338 | Evaluating The Feasibility of A Mobile Coaching Intervention to Improve HPV Vaccine Delivery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to examine the feasibility of using Checkup Coach, a mobile coaching intervention, to improve the way that primary care providers recommend HPV vaccination to adolescent patients and their parents. To conduct this feasibility study, the investigators will deliver the Checkup Coach intervention to 20 Kaiser Permanente Washington primary care providers who routinely recommend HPV vaccine to adolescent patients. The investigators will use a single-arm, … |
MELISSA B GILKEY; | 2021-06-21 |
| 339 | Interventional Study on Efficacy of Lactobacillus Crispatus M247 in Patients Affected By HPV Low-grade Preneoplastic Cervical Lesions and Evaluation of Vaginal Microbiota Changes Before and After Oral Supplementation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients affected by ASC-US/ low-grade HPV cervical lesions will be randomly assigned to treatment arm vs control arm. The treatment arm will include the characterization of the vaginal microbiota at enrollment (T0), 4 months of oral treatment with Lactobacillus Crispatus M 247 (1 buccal stick Die), characterization of the vaginal microbiota at 1 month post treatment (T5 m). The vaginal microbiota will be evaluated by Danagene microbiome vaginal DNA KIT-XMICROGem (XBIOGem) test, with amplification of the variable regions of the 16S ribosomal RNA gene, using the MICROBIOTA kit (CE-IVD – … |
FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS | 2021-06-16 |
| 340 | Immune Modulation By Abemaciclib in HPV-Negative Head and Neck Squamous Cell Carcinoma (HNSCC): A Randomized Phase II Window Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, parallel, open label Phase II single-arm window trial to assess the clinical and biological effects of neoadjuvant abemaciclib in patients with HPV-negative head and neck squamous cell carcinoma (HNSCC). |
RICKLIE JULIAN; | 2021-06-16 |
| 341 | Evaluation of The Efficacy of An Intravaginal Treatment With Carboxymethyl-β-glucan and Polycarbophil on The Regression of Low-grade Cervical Intraepithelial Lesions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A therapeutic strategy to neutralize the evasion mechanisms of HPV. Among these treatments are beta-glucans, polysaccharides of beta-D-glucose that, can influence the clearance of HPV. The objective of this study is to evaluate the efficacy of a gel with Carboxymethyl – β -Glucan and polycarbophil when applied intravaginally, on the regression of low-grade cervical intraepithelial lesions (CIN) associated to HR-HPV infection. |
JUAN JOSÉ HERNÁNDEZ AGUADO; | 2021-06-15 |
| 342 | Evaluation of The Efficacy of An Intravaginal Treatment With Carboxymethyl-β-glucan and Polycarbophil in The Clearance of High-risk Human Papillomavirus Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: These treatments are beta-glucans, polysaccharides of beta-D-glucose that, can influence the clearance of HPV infection. The objective of this study is to evaluate the efficacy of a gel with Carboxymethyl – β -Glucan and polycarbophil when applied intravaginally regarding the clearance of HPV infection. |
JESÚS DE LA FUENTE VALERO; | 2021-06-15 |
| 343 | An Open Label, Single Arm, Safety Lead-in, Multicenter, Investigator Initiated Trial of Combination of Durvalumab , An Immune Checkpoint Inhibitor, and BVAC-C, A Cell-based Immunotherapeutic Vaccine, in Patients With HPV 16 or 18 Positive Cervical Cancer Failure to First-Line Platinum-based Chemotherapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an exploratory, open label, multi-center trial to evaluate the safety and efficacy of combination of durvalumab with BVAC-C in patients with cervical cancer refractory to or relapse after platinum-based first-line chemotherapy with safety lead-in phase. The study consists of 2 parts: part A, a safety lead-in phase, and part B, an exploratory safety and efficacy evaluation phase. Part A will be conducted as a 3+3 dose escalation manner, and part B will be conducted as a non-randomized single arm study. •Part A: Open-labeled; 3+3 dose-escalation; Multi-center; safety lead-in phase •Part B: Open-labeled; Non-randomized, Single arm; Multi-center, … |
SAMSUNG MEDICAL CENTER | 2021-06-14 |
| 344 | A Phase 1, First in Human, Open-label, Dose Escalation and Dose Expansion Study of TST005 in Patients With Locally Advanced or Metastatic Solid Tumors PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label Phase 1, first-in-human (FIH) study of TST005, a bi-specific antibody consisting of a PD-L1 monoclonal antibody (mAb) and a transforming growth factor beta (TGF-β) trap in subjects with locally advanced or metastatic cancers |
MINAL BARVE; | 2021-06-11 |
| 345 | Comparison of Two Surgical Approaches in The Treatment of Cervical Dysplasia: Complete Removal of The Transformation Zone (LLETZ) Versus Isolated Resection of The Colposcopically Visible Lesion (LEEP) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical dysplasia is the precursor of cervical cancer. LEEP and LLETZ are standard surgical procedures to treat cervical dysplasia. There is no direct head-to-head comparison between LEEP and LLETZ in the literature regarding oncologic safety, … |
CLEMENS TEMPFER; | 2021-06-07 |
| 346 | Assessment of Patients’ Quality of Sexual Life After Anal Cancer Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this this study, to evaluate the quality of sexual life of patients treated for anal cancer treated by radiotherapy, during their treatment, then 3 months after treatment and, finally, 2 years after treatment. cancer diagnosis. |
INSTITUT DU CANCER DE MONTPELLIER VAL D’AURELLE | 2021-06-06 |
| 347 | A Multi-center, Randomized, Double-blind, Placebo-controlled Phase IIc Clinical Trial of ALA-PDT in Patients With Cervical Intraepithelial Neoplasia Grade 2 (CIN2) in P16-positivity and High-risk HPV Infection PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Efficacy and Safety of ALA-PDT in patients with cervical intraepithelial neoplasia grade 2 (CIN2) in p16-positivity and high-risk HPV infection. |
SHANGHAI FUDAN ZHANGJIANG BIO PHARMACEUTICAL | 2021-05-31 |
| 348 | HPV Vaccination (Human Papilloma Virus), or How to Address Male Homosexuality in General Practice in Alsace? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to find out whether young MSM (men who have sex with men) believe it is important for their GP to be informed of their sexual orientation, in order to improve their clinical, especially with HPV vaccination. The secondary objective is to analyze the state of knowledge about the HPV vaccine and the value of HPV vaccine in this target population. |
UNIVERSITY HOSPITAL STRASBOURG FRANCE | 2021-05-27 |
| 349 | Impact of A VR Headset on Pain Perception and Satisfaction During Colposcopic Workup of Cervical Precancerous Lesions: A Multicenter Randomized-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the screening smear test at the gynecologist’s office and can thus contribute to a 100% chance of cure if they are clarified by a colposcopic examination as part of the dysplasia consultation. To detect cervical dysplasia during colposcopic examination, … |
GÜNTHER REZNICZEK; | 2021-05-25 |
| 350 | Impact of Catch-up HPV Vaccination on The Development of Cervical Lesions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Each year in France, more than 6000 new cases of HPV inducted cancers are recorded. The vaccinal cover stays insufficient since less than 30% of the french population is vaccinated. Therefore french studies about vaccine efficacy and especially about the catch-up vaccine (done after 15years old) are needed. HPVAC2 is a prospective, analytic and monocentric study designed to learn the impact of the catch-up HPV vaccination. Women from 25 years old and born after 1984 may be included if they come to the Brest CHU to do their regular cervical smear. At this time, … |
UNIVERSITY HOSPITAL BREST | 2021-05-21 |
| 351 | A Phase 3, Open-label Clinical Study to Evaluate The Immunogenicity and Safety of 9vHPV Vaccine, in Japanese Boys and Girls, 9 to 15 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is the estimation of the human papillomavirus (HPV) 6, 11, 16, 18, 31, 33, 45, 52 and 58 seroconversion at 1 month post last dose (Month 7) following 3 doses and 2 doses of the 9vHPV vaccine. No hypothesis will be tested since this study is an estimation-only study. |
MERCK SHARP & DOHME | 2021-05-17 |
| 352 | A Phase 3, Open-Label, Randomized Trial to Investigate The Immunogenicity and Safety of The Co-administration of A Subcutaneous Dengue Tetravalent Vaccine (Live, Attenuated) (TDV) and An Intramuscular Recombinant 9-Valent Human Papillomavirus (9vHPV) Vaccine in Subjects Aged ≥9 to <15 Years in An Endemic Country for Dengue PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to demonstrate the non-inferiority (NI) of the immune response to 2 doses of 9vHPV vaccine, 1 co-administered with TDV, compared with 2 doses of 9vHPV vaccine administered alone. |
TAKEDA | 2021-05-15 |
| 353 | Population Burden of Sexually Transmitted Infections and Implication for Intervention in Hong Kong PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 5-year cross-disciplinary sexually transmitted infection (STI) project involving a) territory-wide and community-based studies (survey and specimen collection); b) simulation of STI transmission dynamics and comparison of STI intervention strategies through mathematical modelling and cost-effectiveness analysis. The aim of this project is to assess the burden and the transmission dynamics of STIs in the general population and men who have sex with men (MSM) in Hong Kong. Around 1300 sexually experienced adults and 900 MSM would be recruited, 100 participants would be invited for individual in-depth interviews. Main outcome measures include STI history and service preference, … |
NGAI SZE WONG; | 2021-05-13 |
| 354 | A Phase 1/2 Open-Label Multi-Center Study to Characterize The Safety and Tolerability of RPTR-168 in Patients With Relapsed/Refractory HPV-16 E6/E7 Positive Tumors and Melanoma Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the safety and tolerability of escalating doses of RPTR-168 as a monotherapy in patients with HPV-16 E6/E7 positive tumors (HNSCC, cervical) and melanoma. |
REPERTOIRE IMMUNE MEDICINES | 2021-05-10 |
| 355 | Screening Protocol to Assess The Expression of Tumor Associated Antigens (TAAs), Human Papillomavirus (HPV-16) Antigens and Human Leucocyte Antigen (HLA) Sub-Types in Patients With Head and Neck, Cervical, Melanoma and Non-Small Cell Lung Cancers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to obtain archived tumor tissue or pre-existing antigen expression data from patients with Head and Neck, Cervical, Melanoma and Non-Small Cell Lung Cancers to assess antigen expression and patient suitability for a Repertoire Immune Medicines Treatment Protocol. |
REPERTOIRE IMMUNE MEDICINES | 2021-05-05 |
| 356 | HPV Prevalence in Transpersons – A Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, Human Papilloma Virus (HPV) prevalence will be determined once in the urine of 200 trans people. In addition, subjects will be asked to complete a questionnaire about their sexual orientation, which is adapted from the largest published study. |
SOPHIE PILS; | 2021-05-02 |
| 357 | HPV ECHO: Increasing The Adoption of Evidence-based Communication Strategies for HPV Vaccination in Rural Primary Care Practices PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The safe, highly-effective human papillomavirus (HPV) vaccine remains underused in the US; only 51% of 13- to 17-year-old girls and boys were up-to-date by 2018. The Announcement Approach Training is effective in increasing HPV vaccine uptake during the clinic visit by training providers to make strong vaccine recommendations and answer parents’ common questions. Systems communication like recall notifications also improve vaccination by reducing missed clinical opportunities. Although never tested to support HPV vaccination, … |
WILLIAM CALO; | 2021-05-01 |
| 358 | A Safety and Efficacy Study of Intra-tumoural Diffusing Alpha Radiation Emitters (DaRT) for The Treatment of Primary and Recurrent Squamous Cell Carcinoma of The Vulva PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: An investigation to investigate the use of diffusing alpha-emitters radiation therapy (DaRT) for the treatment of new and recurrent squamous cell carcinoma of the vulva. |
CCTU- CANCER THEME; | 2021-05-01 |
| 359 | Qualitative Study Evaluating Opinions Regarding HPV Vaccinnation in Boys’ Parents Aged From 11 to 14 Years Old PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The human papilloma virus infection is the most frequent sexually transmitted infection around the world. In the vast majority of cases, these are inapparent infections that disappear spontaneously. In some cases, the HPV infection persists and can generate anogenital warts or cancer. In France, the papillomavirus is responsible for 6000 new cases of cancer/year with several possible localizations : cervical, anal, penile, oropharyngeal, vulvar or vaginal. Among them, 4580 new cases of cancer/year occur in women, and half of them are diagnosis of cervical cancer. A quarter of cancers caused by papillomavirus occur in men. In France, … |
CENTRE HOSPITALIER EURE SEINE | 2021-05-01 |
| 360 | Utbildningsnivå, Invandringsstatus Och Viljan Att Vaccinera Mot HPV Som Funktion Av Informationsformulering: En Randomiserad Studie PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Counteracting misinformation on childhood vaccines remains a priority for public health in industrialized countries. Previous research showed that misinformation-induced vaccine hesitancy particularly concerns very highly or very lowly educated parents, and, especially in Europe, specific groups of immigrants. Misinformation framing directly targets specific sub-population of parents by exploiting different cognitive biases, and specific concerns based on cultural norms: this project aims at testing the effectiveness of similar framing techniques applied to positive information on the HPV vaccine by conducting a Randomized Controlled Trial in Stockholm, … |
LISEN ARNHEIM DAHLSTROM; | 2021-04-28 |
| 361 | Increasing Cervical Cancer Screening Among Female Patients at Penn State Health St. Joe’s Residency Clinic: Letter Notifying Them About Outdated Screen and Postcard With Self-sampling Option PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the effectiveness of offering self-sampling for high risk human papilloma virus (HPV) testing in order to increase the number of women who are screened for cervical cancer. The hypothesis of this study is that women who are notified of a need for cervical cancer screening by letter and are also offered a self-sampling kit for cervical cancer screening will have a higher rate of screening than women notified by letter alone. This study will use an intervention arm (letter and option to request a self-sampling kit) compared to a control arm (letter alone, standard of care) as a reminder that they are out of date for their cervical cancer screening. Women who are out of date with their cervical cancer screening will be identified using the Electronic Medical Record and randomized to the study group in a 2 to 1 ratio (2 for the control arm and 1 to the intervention arm). The primary endpoint that will be evaluated in this study is the method of completion of cervical cancer screening and the use of the self-sampling kit, which will be monitored over a three month period after the letters have been mailed. A secondary endpoint will be the overall rate of cervical cancer screening of all people mailed a letter. |
CHRISTINA SCARTOZZI; | 2021-04-26 |
| 362 | Vaginal Microbiota Transplant to Promote Lactobacillus-dominant Cervicovaginal Communities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis. |
DOUGLAS KWON; | 2021-04-22 |
| 363 | Exploratory Sequential Mixed Methods Cluster Randomized Controlled Implementation Science Trial to Develop A Clinic-based HPV and COVID-19 Vaccine Promoting Intervention for African American Older Adolescents in Rural Alabama Related Papers Related Patents Related Grants Related Experts View Highlight: In this 30-month study, the investigators propose to develop a culturally appropriate vaccine confidence intervention, targeting positive change related to HPV vaccine uptake behavior and reducing sentiments of hesitancy towards a COVID-19 vaccine, that can be seamlessly integrated into the existing environment of pediatric and family practice clinics in rural Alabama. To do so, the investigators will first assess stakeholders’ knowledge, sentiments, and beliefs related to vaccination in general, a COVID-19 vaccination, and the HPV vaccination. The investigators will also assess stakeholders’ perceptions of barriers to vaccination that exist in rural Alabama. This will occur in Aim 1. Then, … |
HENNA BUDHWANI; | 2021-04-20 |
| 364 | A Phase III, Randomized, Double-blind Study to Assess The Consistency of The Immunogenicity of Three Consecutive Production Lots of Bivalent HPV Vaccine in Healthy Female Subjects Aged 9 – 30 Years and to Demonstrate Non-inferiority of The Candidate HPV Vaccine Manufactured at Commercial Scale Compared With A Pilot Scale PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the immunogenicity and safety of three consecutive lots of bivalent HPV (Type 16,18) vaccine (Pichia pastoris) in healthy female subjects aged 9 – 30 years, and demonstrate the non-inferiority of the candidate HPV vaccine manufactured at commercial scale compared with a pilot scale. |
TING HUANG; | 2021-04-19 |
| 365 | Randomized Participation Trials: Increase in Response By Offering Self-sampling Devices in Belgian GP Practices to Non-screened Women PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Small scale data indicate that cervical cancer screening participation may increase when self-sampling (SS) devices are offered directly by health care workers to non-screened woman, when those woman contact health services for whatever reason. The purpose of the current research is to reproduce the early findings of a MSc project conducted in a general practitioners (GP) group practice in Brussels, … |
GUY BEUKEN; | 2021-04-19 |
| 366 | The Durability of Protection and Immuno-persistence Study of A Bivalent Human Papillomavirus (Type 16, 18) Recombinant Vaccine (E.Coli) in Healthy Women Aged 18 to 45 Years PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the durability of protection and immuno-persistence of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine administered in females aged 18-45 years. |
JUN ZHANG; | 2021-04-13 |
| 367 | Follow-up Study for Patients Having Received FluBHPVE6E7 in Clinical Studies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a follow-up study for patients treated with FluBHPVE6E7 in previous interventional studies. |
BLUESKY IMMUNOTHERAPIES | 2021-04-09 |
| 368 | Evidence-Based Approach to Empower Asian American Women in Cervical Cancer Screening PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized trial to evaluate the effects of a community-based intervention on increasing cervical cancer screening rates in underserved Asian American (Korean, Vietnamese, and Chinese) women. All women will receive an educational program and navigation assistance. Women in the intervention condition will also receive a self-sampling kit for self-collection of a cervical sample for HPV testing. The investigators will evaluate whether the inclusion of a self-sampling kit increases the proportion of Asian American women who participate in cervical cancer screening. |
CAROLYN FANG; | 2021-04-08 |
| 369 | A Phase 1 Study of RTX-321 for The Treatment of Patients With Advanced Malignancies Associated With Human Papillomavirus-16 Infection Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label, multicenter, multiple-ascending dose, FIH, Phase 1 study of RTX-321 for the treatment of patients that are HLA-A*02:01 positive with persistent, recurrent, or metastatic, unresectable, HPV 16+ cancers. |
RUBIUS THERAPEUTICS | 2021-04-08 |
| 370 | ERADICATING CERVICAL CANCER IN KENYA: Benefits of Community-based Prevention, and The Effects of Aflatoxin on HPV Vaccination PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: We propose a study of a strategy designed to 1) increase cervical cancer screening using a community-based approach, and 2) determine the efficacy of HPV vaccination in a region of Kenya where half of all children are chronically exposed to aflatoxin. |
DARRON BROWN; | 2021-04-01 |
| 371 | The Durability of Protection Study of A Bivalent Human Papillomavirus (Type 16, 18) Recombinant Vaccine (E.Coli) in Healthy Women Aged 18 to 45 Years PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the durability of protection of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine administered in females aged 18-45 years. |
JUN ZHANG; | 2021-03-30 |
| 372 | A Phase II, Open-Label, Multi-Center Study of PDS0101 and Pembrolizumab (KEYTRUDA®) Combination Immunotherapy in Subjects With Recurrent And/or Metastatic HNSCC and High-Risk HPV16 Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: VERSATILE-002 is a Phase 2, open-label, multicenter study of the efficacy and safety of PDS0101 administered in combination with pembrolizumab in adults with HPV16 and PD-L1 positive recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). |
PANAYIOTIS SAVVIDES; | 2021-03-29 |
| 373 | Assessment of New Technologies for The Screening and Diagnosis of Cervical Cancer in Mozambique, A Study to Be Conducted in Maputo Central Hospital, Mavalane and Jose Macamo General Hospitals and Mavalane Health Center PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to compare the accuracy of the lateral flow test to detect HPV at the POC with the commercially available GeneXpert HPV test and to determine the diagnostic accuracy and reliability of a multimodal optical imaging system to detect cervical dysplasia, with the gold reference standard of histopathology. |
KATHLEEN SCHMELER; | 2021-03-24 |
| 374 | Improving Detection and Early Action for HPV-positive Oropharynx Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to determine whether a blood test for HPV DNA can improve diagnosis of HPV-positive oropharynx cancer (HPV-OPC). |
ELENI M. RETTIG; | 2021-03-24 |
| 375 | A Phase II Study to Determine The Efficacy and Safety of Vvax001, A Therapeutic Semliki Forest Virus Based Cancer Vaccine, in Patients With HPV-16 Induced Grade 3 Cervical Intraepithelial Neoplasia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open label phase II study in patients with newly diagnosed human papilloma virus type 16 (HPV16) induced cervical intraepithelial neoplasia grade 3 (CIN3). Patients will be treated with three doses of Vvax001 immunization with an interval of 3 weeks between each immunization to induce histopathological regression and HPV clearance. Regression of CIN3 lesions will be monitored using colposcopy in week 9, week 17 and week 25. When complete regression of the CIN3 lesion is observed by colposcopy, … |
REFIKA YIGIT; | 2021-03-23 |
| 376 | A Phase 1b/2, Randomised, Placebo-controlled, Dose-ranging Study to Evaluate Safety, Tolerability and Immunogenicity of A Chimpanzee Adenovirus (ChAdOx1)-Vectored Multigenotype High Risk Human Papillomavirus (hrHPV) Vaccine and Modified Vaccinia Ankara (MVA)-Vectored Multigenotype HrHPV Vaccine in Women With Low-grade HPV-related Cervical Lesions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase 1b/2 multi-centre study evaluating the safety, efficacy and immunogenicity of prime-boost vaccines ChAdOx1-HPV and MVA-HPV in women with HPV related low grade cervical lesions. |
VACCITECH UK | 2021-03-16 |
| 377 | New Prognostic and Predictive Biomarkers for HPV-associated Oropharyngeal Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study involves the coexistence of a retrospective part, in which a group of patients with HPV-associated OPC for whom follow-up data of at least 2 years after diagnosis are available, designed in order to evaluate the expression of HPV16-specific E5 transcript as well as that of pEGFR and HLA, and a multicenter prospective part, involving the enrollment of a control group, enrolled at the ENT outpatient clinic of the IRE and the outpatient clinics of the relevant LILT provincial committees, to better elucidate the role of HPV16-E5 in identifying potentially transforming infections due to the presence of HPV. |
REGINA ELENA CANCER INSTITUTE | 2021-03-15 |
| 378 | A Randomized, Single-blind Study to Compare Immunogenicity of A Recombinant Human Papillomavirus Nonavalent (Types 6,11,16,18,31,33,45,52,58) Vaccine(E.Coli) (Xiamen Innovax Biotech Co.,Ltd.) Versus Gardasil®9 (Merck & Co., Inc.) in Healthy Females 18-26 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is designed to compare the immunogenicity of a novel recombinant human papillomavirus vaccine (types 6,11,16,18,31,33,45,52,58 )(E.Coli) manufactured by Xiamen Innovax Biotech CO., Ltd., with Gardasil®9 in females 18-26 Years of Age. |
JUN ZHANG; | 2021-03-14 |
| 379 | Extended VALidation of HUman Papillomavirus Assays and Collection DEvices for HPV Testing on Self-samples and First-void Urine Samples PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The Extended VALHUDES study is a Clinical Performance / Diagnostic Test Accuracy Study that aims to extend validation, achieved as part of the Belgian VALHUDES, of HPV testing using BD Onclarity on samples collected using Copan’s devices for dry self-sampling of vaginal material and for first-void urine: FLOQSwab® 5E089N and UriSponge™. |
CLEMENTINA COCUZZA; | 2021-03-08 |
| 380 | Endocervical Curettage Performed With A Kevorkian Curette Versus Cytobrush in Patients With ASC-H, LSIL, ASCUS HPV Positive and Non-contributory Colposcopy (ZT3) Smear or Atypical Pap Smear With Positive HPV Test PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The recommendations on the method and the realization of the cervico-uterine smears are clear. With regard to performing endocervical curettage, several methods are possible without precise consensus. In general, the Kevorkian curette is widely used. However, it is often reported by doctors and patients that curettage is painful. Some articles show that the cytobrush would be less painful. While keeping a percentage of correct curettage failures, it is sought to show that the cytobrush would improve the comfort of the patient during curettage. |
SOPHIE JONARD; | 2021-03-01 |
| 381 | The Effect of Dexmedetomidine on Oxygen and Intrapulmonary Shunt During One Lung Ventilation in Pediatric Surgery: Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The children who will undergo OLV (one lung ventilation) through general anesthesia will be divided into two groups: The first will be intravenous infusion of dexmedetomidine at 0.4 mcg / kg / hour, and the second will be intravenous infusion of normal saline. We will take three samples of arterial blood gas (ABG) during the surgery at certain times. We record the hemodynamic values, PaO2, and calculate the value of the shunt Qs / Qt. |
DAMASCUS UNIVERSITY | 2021-03-01 |
| 382 | Evaluation of The Prevalence and Type of Oral HPV Infection in Patients Who Are Positive to The PAP-test PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present cross-sectional study aims to assess the prevalence and type distribution of oral HPV infection in PAP-test-positive women aged ≥18 years. The means used in the present study will be the use of anamnestic questionnaires and exfoliative cytology tests at predetermined oral mucosal sites (lingual belly and dorsum, palate, and buccal mucosa). |
GAETANO ISOLA; | 2021-03-01 |
| 383 | Nine-valent HPV Vaccine to Prevent Persistent Oral HPV Infection in Men Living With HIV PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blinded, placebo-controlled Phase III interventional trial of the nine-valent HPV vaccine (9vHPV) to prevent persistent oral HPV infection in adult men living with HIV. |
GRANT ELLSWORTH; | 2021-02-23 |
| 384 | Alinity M HR HPV Specimen Collection Study From Women Undergoing Routine Cervical Cancer Screening PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: A prospective multicenter interventional study will be conducted to enroll women undergoing routine cervical cancer screening to collect cervical liquid-based cytology (LBC) specimen(s). For all subjects, two cervical specimens will be collected, and one placed into Hologic ThinPrep Pap Test collection kit with PreservCyt Solution (also referred to as ThinPrep specimen) and the other into BD SurePath liquid-based Pap test (also referred to as SurePath specimen). Cytology and HR HPV results will be generated and utilized to determine need for subject referral to colposcopy. Collection of an endocervical curettage (ECC) specimen, and biopsy(ies) if applicable, … |
ABBOTT MOLECULAR | 2021-02-22 |
| 385 | Multilevel Intervention Based on CRC and Cervical Cancer Self-screening in Rural, Segregated Areas PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this study, the investigators will deliver self-sampling human papillomavirus (HPV) tests and fecal immunochemical test (FIT) kits, as well as adapted cancer screening educational materials, by mail to 110 women who are out-of-date for both cervical and colorectal cancer screenings, recruited through federally qualified health centers (FQHCs) in rural, segregated counties of Pennsylvania. The hypothesis is that delivering self-sampling HPV tests and FIT, as well as adapted educational materials, to women in rural, segregated areas could help increase cancer screening, reduce geographic cancer disparities, and improve public health. |
JENNIFER L. MOSS; | 2021-02-18 |
| 386 | Health Beliefs, Behaviors, and Healthcare Experiences Among A National Sample of United States Young and Mid-Age Adults PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will provide important insight into current HPV vaccine knowledge/awareness, health beliefs, affect, vaccine discussions, decision preparedness, and vaccine intentions and behaviors among those ages 18-45, while examining potential differences in responses between those ages 18-26 and those ages 27-45 and vaccinated and unvaccinated individuals. |
SHANNON M CHRISTY; | 2021-02-17 |
| 387 | A Tailored, Health Communication Intervention for HPV Vaccine Hesitant Families PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The human papillomavirus (HPV) causes 90% of cervical cancers and is implicated in multiple other cancers. The HPV vaccine can prevent the vast majority of these cancers, but it is underused in adolescents, especially among those within vaccine hesitant (VH) parents. The proposed research is to develop and pilot test a tailored, health communication intervention aimed to increase HPV vaccination among VH parents. The proposed research is innovative because no evidence-based health communication interventions target HPV VH parents, … |
MEHARRY MEDICAL COLLEGE | 2021-02-15 |
| 388 | County Level Correlates of HPV Vaccine Series Completion Among Children Ages 11-14 Years in Indiana PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall objective is to document geographic variability in HPV vaccine series completion across the state of Indiana and to identify factors associated with low versus high rates of completion. Objective a: To map HPV vaccine series completion rates across Indiana’s 92 counties for children aged 14 years and younger. Hypothesis: The investigators expect wide variability in completion rates from county to county. Further, the investigators expect significantly less variability in county-level administration of vaccines required for middle-school entry (Tdap, MenACWY, … |
GREGORY ZIMET; | 2021-02-09 |
| 389 | Immuno-persistence Study of A Bivalent Human Papillomavirus (Type 16, 18) Recombinant Vaccine (E.Coli) in Healthy Female Subjects Aged 9 to 17 Years PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to evaluate the immuno-persistence (type specific IgG antibody) of the tested vaccine administered in girls aged 9-17 years,comparing to young healthy adults of 18-26 years who received the standard 3-dose schedule (0,1,6 months). |
JUN ZHANG; | 2021-02-06 |
| 390 | Education Intervention on Vaccination Adherence Among IBD Patients at Weill Cornell Medical Center PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A retrospective chart review and a six-month prospective outcome analysis aimed to evaluate the efficacy of a vaccination education intervention and vaccination adherence among IBD patients at Weill-Cornell Medical Center. It is hypothesized that a general vaccination education campaign will improve vaccination adherence rates for all IBD patients. Secondarily, it is hypothesized that an Human Papilloma Virus (HPV) vaccination intervention targeted at high-risk IBD patients will increase vaccination adherence among these patients. |
DANA J LUKIN; | 2021-02-04 |
| 391 | A Phase II Trial Assessing Bintrafusp Alfa, A Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in A Pre-operative Setting for Resectable and Untreated Head and Neck Squamous Cell Carcinoma Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective open label, multicenter, phase II, window-of-opportunity preoperative, single-agent trial. This study aims to evaluate the efficacy, the safety and tolerability profile of bintrafusp alfa in patients with histologically or cytologically confirmed squamous cell carcinoma of the oral cavity, oropharynx, larynx or hypopharynx, previously untreated, with indication of primary surgery. Patients with a diagnosis of head and neck squamous cell carcinoma (HNSCC) from unknown primary will not be enrolled. |
CAROLINE HOFFMANN; | 2021-02-04 |
| 392 | Implementation of A Provider-Focused Intervention for Maximizing HPV Vaccine Uptake in Young Cancer Survivors Receiving Follow-Up Care in Pediatric Oncology Practices: A Cluster-Randomized Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The focus of this research is on increasing the uptake of the human papillomavirus (HPV) vaccine in young cancer survivors, a vulnerable population at high risk for developing new cancers (such as cervical and anal cancer) caused by persistent HPV infection. An effective vaccine exists that can prevent these cancers, but HPV vaccine uptake is low among young cancer survivors. This research will evaluate the effectiveness and implementation of an evidence-based intervention, adapted for use by healthcare providers in pediatric oncology clinics, … |
WENDY LANDIER; | 2021-02-01 |
| 393 | Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Almost half of all women will develop an HPV infection in their lifetime. While most infections are naturally asymptomatic or cleared by the immune system, some persist and can lead to the development of cervical, vulvar, or anal lesions and eventually cancer. Screening regimens for these lesions are currently only in place for the cervix through regular Pap tests. These Pap tests usually involve an examination of the vulva -however, … |
DANIELLE VICUS; | 2021-02-01 |
| 394 | PROMOTE Pilot Study: Pharmacy Multimodal Communication Strategy to Promote HPV Vaccination PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial investigates how a communication strategy works in increasing human papillomavirus (HPV) vaccines in community pharmacies among adolescents. Although pharmacies are vaccine providers, low vaccination rates are persistent as a result of low awareness of pharmacy services and poor engagement by pharmacy staff with adolescents about vaccines. The purpose of this study is to test a communication strategy that identifies vaccine-eligible children and teaches pharmacy staff how to effectively communicate with them about HPV vaccination in order to increase HPV vaccination rates. |
PARTH SHAH; | 2021-02-01 |
| 395 | The Impact of Co-infections on Inflammation in Patients Commencing Second-line Antiretroviral Therapy. A Sub-study of D²EFT (Dolutegravir and Darunavir Evaluation in Adults Failing Therapy) Related Papers Related Patents Related Grants Related Experts View Highlight: i2-D²EFT substudy is an observational cohort nested within the parent D²EFT study (NCT03017872). D²EFT goal is to compare the standard of care second-line antiretroviral therapy in people living with HIV whose first-line non nucleoside reverse transcriptase-based regimen failed, to two simpler regimens. Approximately 1,000 participants will be enrolled in D²EFT. Commencing a second-line ART is an important moment when the level of inflammation in participants may be elevated due to first-line ART failure; this level of inflammation should then decrease with the commencement of a new second-line treatment and would be expected to normalise by 48 weeks of second-line treatment, … |
MARK POLIZZOTTO; | 2021-02-01 |
| 396 | Single Patient Protocol: A Study Using The Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in A Patient With Metastatic Cancer Plus The Administration of Pembrolizumab Related Papers Related Patents Related Grants Related Experts View Highlight: Background: A cancer treatment has been developed called gene transfer or gene therapy. It involves taking white blood cells from a person (called apheresis), genetically modifying the cells in a lab to recognize cancer, … |
STEVEN A ROSENBERG; | 2021-01-27 |
| 397 | A Message Framing Intervention for Increasing Parental Acceptance of Human Papillomavirus Vaccination PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to determine the effects of message framing (gain vs. loss) on African American parents’ acceptance of the HPV vaccine and how such effects are moderated by parents’ salient beliefs prior to message exposure. Participants are randomized into gain and loss conditions in which they view either gain-framed or loss-framed HPV vaccination messages. Key outcome variables include parents’ attitudes and intentions toward vaccinating their children against HPV. |
XIAOLI NAN; | 2021-01-22 |
| 398 | A Pilot Study of E7 TCR T Cell Induction Immunotherapy for Stage IIB-IVA Cervical Cancer Related Papers Related Patents Related Grants Related Experts View Highlight: Background: More than 12,000 cases of cervical cancer are diagnosed in the United States each year. A new therapy has been developed that involves taking white blood cells from a person, genetically modifying the cells in a lab so they recognize cancer, … |
SCOTT NORBERG; | 2021-01-14 |
| 399 | Prospective Clinical Study on The Role of Multiple Human Papillomavirus Infections in Lower Genital Tract Dysplasias and Its Interactions with HPV Vaccination PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Multiple infections of high-risk genotypes of Human Papillomavirus (HR-HPV) in patients with abnormal cervical cytological or histological findings are detectable in a percentage ranging from 20% to 50% of cases. Some studies have detected a certain tendency to specific clustering in multiple infections, both inter-species and inter-genotypic, such as HPV 31-35-56, HPV 16-51-52, HPV 16-18, HPV 51-52. Furthermore, a greater tendency of the HPV16 genotype to cluster with genotypes of different species is reported in the literature. However, … |
BARBARA GARDELLA; | 2021-01-08 |
| 400 | HPV Self-sampling Among Women at Penn State Hershey Well Women Appointments PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to compare the accuracy and acceptability of Human Papillomavirus (HPV) testing self-sampling kit versus standard clinician-sampled HPV testing for cervical cancer screening. The primary outcome of this study is the concordance between screening results on self-sampling kits compared to clinician-collected HPV test and Pap smear results. Secondary endpoints will include acceptability of self-sampling and barriers to cervical cancer screening. These endpoints will be analyzed to try to circumvent barriers to the cervical cancer screening and ascertain whether self-sampling is a viable alternative to clinician sampling. |
JENNIFER L. MOSS; | 2021-01-07 |
| 401 | HPV Vaccine Hesitancy Among Indiana Youth With Cancer and Blood Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: For the identified groups of patients (survivors of childhood cancer and youth with sickle cell disease) the investigators want to better understand the barriers to, and facilitators of, HPV vaccination. Through HCP interviews the investigators will also assess both attitudinal and logistical obstacles to HPV vaccination. Some subspecialty HCPs may believe, for instance, that it is the primary care provider’s responsibility to vaccinate or they may be unfamiliar with the requirement to enter vaccination data into CHIRP. Also, … |
SCOTT COVEN; | 2021-01-04 |
| 402 | Study on Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to establish an early warning model for a high-risk population of cervical cancer. |
DING MA; | 2021-01-01 |
| 403 | HPV Self-sampling Among Women at The Penn State Hershey Colposcopy Clinics PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study seeks to compare the accuracy and acceptability of HPV testing self-sampling kit and standard clinician-sampling for HPV testing. The primary outcome of this study is the concordance between screening results on self-sampling kits compared to clinician-collected HPV test, Pap smear results, and colposcopy. Secondary endpoints will include acceptability of self-sampling and barriers to cervical cancer screening. These endpoints will be analyzed to try to circumvent barriers to the cervical cancer screening and ascertain whether self-sampling is a viable alternative. |
JENNIFER L. MOSS; | 2020-12-09 |
| 404 | Randomised, Double-blind, Placebo-controlled Phase 1 Dose-escalation Study of FluBHPVE6E7 in HPV-16 Infected Women With Normal Cytology, CIN1 or CIN2 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: BS-01 is a randomised, double-blind, placebo-controlled, phase 1 dose escalation study assessing safety, tolerability and immunogenicity of FluBHPVE6E7, changes in the HPV infection status and cervical cytology, and biodistribution in HPV-16 infected women with normal cytology, CIN1 or CIN2. The safety and immunogenicity of two dose levels, 7.5 log10 and 9.0 log10 fTCID50/dose of FluBHPVE6E7 are assessed after three subcutaneous administrations. In addition the safety of 9.0 log10 fTCID50/dose of FluBHPVE6E7 is assessed after three intradermal or intramuscular administrations. |
BLUESKY IMMUNOTHERAPIES | 2020-12-09 |
| 405 | A Multi-centre, Blinded, Randomized and Gardasil-controlled Phase III Trial to Evaluate The Efficacy, Immunogenicity and Safety Profile of Recombinant Nonavalent (Types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia Coli) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to demonstrate that the administration of the investigational vaccine can reduce the Combined Incidence of HPV types 6/11/16/18/31/33/45/52/58-related high-grade Cervical Intraepithelial Neoplasia (CIN 2/3), Adenocarcinoma in Situ (AIS), Invasive Cervical Carcinoma, high-grade Vulvar Intraepithelial Neoplasia (VIN 2/3), high-grade Vaginal Intraepithelial Neoplasia (VaIN 2/3), high-grade Anal Intraepithelial Neoplasia (AIN 2/3), vulvar cancer, vaginal cancer or anal cancer. |
BEIJING HEALTH GUARD BIOTECHNOLOGY | 2020-12-05 |
| 406 | HYHOPE: Phase I Study of De-intensified Hypofractionated Radiation Therapy for Human Papilloma Virus-associated Oropharynx Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a single arm Phase I study of de-intensified hypofractionated radiation therapy for favorable human papilloma virus-associated oropharynx cancer. It will evaluate the tolerability of a de-intensified hypofractionated radiation therapy regimen completed in 3 weeks (with equivalent biologically effective dose to 60 Gy in 30 fractions) with concurrent weekly cisplatin. |
DOMINIC MOON; | 2020-12-03 |
| 407 | Effects of A Multidisciplinary Team-led School-based Human Papillomavirus Vaccination Health-promotion Programme (MDL-SHPVP) on Improving Vaccine Acceptance and Uptake Among Female Adolescents: A Cluster Randomised Controlled Trial PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The MDL-SHPVP will be developed and a clustered randomised controlled trial will be conducted to evaluate the effects of the MDL-SHPVP and to examine whether the effect of the MDL-SHPVP on the rate of HPV vaccine uptake 1 year after intervention is mediated by parents’/guardians’ and female adolescents’ HPV knowledge, attitudes and beliefs, adolescents’ intention to receive HPV vaccination and vaccine acceptance among their parents/guardians. |
CHAU PAK CHUN JANITA; | 2020-12-01 |
| 408 | Changes in The Prevalence of Oncogenic HPV Types After Introduction of Prophylactic HPV Vaccine Program in Japan PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In Japan, nationwide prophylactic HPV vaccination was implemented in 2010; a bivalent vaccine was given from 2010 to 2012, and a quadrivalent vaccine from 2012. However, the program essentially ceased in June 2013. 1. Our first objective is to examine the prevalence of 6, 11, 16, 18, 31, 33, 45, 52, and 58 targeted by the nonavalent HPV vaccine in young Japanese women, and identify changes in the prevalence of these HPV types from 2011- 2012 (as reported in JHERS-2016; Sasagawa T, J Med Virol, 2016) to the present time (2020-2021). Especially, … |
TOSHIYUKI SASAGAWA; | 2020-12-01 |
| 409 | An Open-Label Clinical Trial Evaluating The Immunogenicity of The 9vHPV Vaccination Regimen Over 6 Months Among Women Aged 16 to 45 Years Old, An Exploratory Immunogenicity Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to explore and evaluate whether a 2-dose schedule of Gardasil 9 among young and mid-adult women 16-45 years of age is generally safe and immunogenic, with an antibody response that is not inferior to that observed of a 3-dose schedule of Gardasil 9 among women aged 16-26 years old. The investigators thought that having a 2-dose vaccination regimen for individuals 16 to 45 would provide a more robust dataset than those of 27 to 45 years old. |
NATALIE JOSEPH; | 2020-12-01 |
| 410 | Phase I/II Trial Investigating The Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta Trap/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Combination immunotherapy techniques are being explored to improve responses and enhance benefits in people with cancer. Researchers want to see if this type of treatment can help people with advanced solid tumors. Objective: To find a safe dose of SX-682 in combined treatment with Bintrafusp alfa and BN-CV301 vaccines and to see if this treatment will cause tumors to shrink. Eligibility: Adults age 18 and older with metastatic cancer may be eligible for the first part of the trial. Adults age 18 and older with metastatic triple negative breast cancer or p16 negative head and neck squamous cell cancer, … |
JAMES GULLEY; | 2020-11-24 |
| 411 | Self-Testing Options in The Era of Primary HPV Screening for Cervical Cancer: The STEP Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The Self-Testing options in the Era of Primary HPV screening for cervical cancer (STEP) trial will evaluate effectiveness of home-based HPV kits for improving cervical cancer screening uptake and its cost-effectiveness. The investigators will compare cervical cancer screening uptake within six months among women randomized to different outreach approaches based on prior screening behavior: A) Adherent and coming due: direct mail HPV kit vs. opt-in HPV kit vs. education; B) Overdue: direct mail HPV kit vs. education; C) Unknown: opt-in HPV kit vs. education. |
DIANA SM BUIST; | 2020-11-20 |
| 412 | LCCC 2044: Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations. |
WENDELL YARBROUGH; | 2020-11-19 |
| 413 | An Extended Follow-Up Study of The HPV Vaccine Delayed Booster Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an extended follow-up study to follow-up study participants who received 1 booster dose of Gardasil 9 in the HPV vaccine delayed booster trial. This was a prospective, single-arm, open-label, non-randomized, phase IIa trial among 9-11 year-old girls and boys to determine the immunogenicity after a single dose of the nonavalent HPV vaccine (Gardasil 9) over 24 months, with a delayed booster dose at 24 months and an optional booster at 30 months after the first dose. Participants provided blood specimens at 6, 12, 18, 24, … |
SHERRY CHOW; | 2020-11-17 |
| 414 | Human Papilloma Virus (HPV) Circulating Tumor DNA (ctDNA) in Cervical Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study collects blood samples to determine if the DNA of HPV that causes cervical cancer can be detected in patients with cervical cancer that is new (primary), has come back (recurrent), or has spread to other places in the body (metastatic) and are undergoing treatment with surgery, radiotherapy, chemotherapy, and/or immunotherapy. Researchers may use this information to predict response (good or bad) of the cervical cancer to treatment and detect recurrent cancer sooner. |
ALLISON E. GARDA; | 2020-11-17 |
| 415 | Papilocare®: Effects on Regression of Histologically Confirmed Cervical Intraepithelial Lesions 1 and Tolerance PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: clinical trial comparing the regression rate after 12 months of histologically confirmed cervical intraepithelial lesions 1 in 2 parallel groups. One group using the vaginal gel Papilocare® for 6 months and one group without any treatment. |
HELENE GBAGUIDI; | 2020-11-17 |
| 416 | Evaluation of Organized Human Papilloma Virus (HPV) Screening of 23-29-year-old Women PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the trial is to determine whether organized screening with primary HPV analysis provide higher cancer protection in the age group 23-29 years compared to primary cytology. |
JOAKIM DILLNER; | 2020-11-16 |
| 417 | HPV Infection and Genital Microecology of Childbearing-age Female in China: A Cohort and Multicenter Study PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study to access the relations between genital microecology, HPV infection and cervical intraepithelial neoplasia of childbearing-age female in China |
MUXUAN CHEN; | 2020-11-12 |
| 418 | Cost-effectiveness of EndWarts® FREEZE for Wart Treatment: A Randomized, Controlled, Investigator-Blinded, Comparative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to study cost-effectiveness of EndWarts® FREEZE for wart treatment, compared to conventional liquid nitrogen cryotherapy |
CHARUSSRI LEEYAPHAN; | 2020-11-12 |
| 419 | A Double Blind, Prospective, Randomized, Placebo Controlled, Multi-center Phase 3 Study to Evaluate Efficacy and Safety of Cevira® in Patients With Cervical Histologic High-grade Squamous Intraepithelial Lesions (HSIL) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A double blind, prospective, randomized, placebo controlled, multi-center phase 3 study to evaluate efficacy and safety of Cevira® in patients with cervical histologic high-grade squamous intraepithelial lesions (HSIL). |
JINGHE LANG; | 2020-11-10 |
| 420 | Study of The Impact of A School Program Combining – Promotion of HPV Vaccination and HPV Vaccine Offer in Middle School – on Adherence to HPV Vaccination in Middle School Students PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer (CCU) is the fourth most common cancer in women worldwide. In Reunion island, CCU is the third leading cause of cancer in women (standardized incidence rate on the world population (TIS) in 2013 of 10.3 / 100,000) and is the eighth deadliest cancer with a rate standardized mortality of 4.8 / 100,000, almost three times higher than in mainland France where it was 1.7 / 100,000 in 2018. CCU results from infection with the human papillomavirus (HPV), … |
CENTRE HOSPITALIER UNIVERSITAIRE DE LA RÉUNION | 2020-11-01 |
| 421 | Immunogenicity of Fractional Dose of The Bivalent and Nonavalent Intradermal HPV Vaccines PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This randomized phase IV trial compares fractional dose of bivalent HPV vaccine to fractional dose of nonavalent HPV vaccine among men and women aged 27-45 years in Seattle, Washington. Participants will have immune response assessed at baseline, 4 weeks, 6 months, 12 months, and 24 months. |
ANNA WALD; | 2020-11-01 |
| 422 | Comparison of Cervical Intraepithelial Neoplasia 2/3 Treatment Outcomes With A Portable LMIC-adapted Thermal Ablation Device Vs. Gas-based Cryotherapy PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this academic-industrial partnership will be to compare two thermoablation modalities using devices adapted to low and middle income countries (LMICs) to traditional CO2-based cryotherapy for the treatment of cervical precancer. The investigators will investigate whether the cure rates of cervical intraepithelial neoplasia 2 and more severe diagnoses (CIN2+) with these devices are non-inferior compared to that of conventional cryotherapy. The results of this study will affect other research areas by serving as a springboard to exploring treatment alternatives that are amenable to low-resource settings and thus will reach the most vulnerable populations. |
MIRIAM CREMER; | 2020-10-30 |
| 423 | Evaluation of Efficacy of AHCC®for The Clearance of High Risk-HPV Infections in Chinese Female: A Multi-centre, Randomised, Double Blind and Placebo-controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-centre, randomised, double blind, placebo-controlled study on female participants with diagnosis of high-risk human papillomavirus (HR-HPV) infection to evaluate the clearance capacity of AHCC®. |
BEIHUA KONG; | 2020-10-26 |
| 424 | Improving Uptake of Cervical Cancer Prevention Services in Appalachia; Testing Multi-Level Interventions to Improve HPV Vaccination: The I Vaccinate Program PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial studies how well a multi-level health system-based intervention works in improving human papillomavirus (HPV) vaccine initiation and completion among children in health systems in four Appalachian states. Utilizing educational and promotional materials and electronic health record reminders, may improve the uptake of the HPV vaccine in children and young adults, ultimately preventing the development of cervical cancer. |
ELECTRA PASKETT; | 2020-10-21 |
| 425 | Acceptance and Completion Rate of Free HPV Vaccination Among Underserved Adult Patients (Age 18-45) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase IV trial examines the impact of an education program on the human papilloma virus (HPV) and its effects on the acceptance and completion rates of a free HPV vaccination program in underserved adult patients. Participating in the HPV educational program may increase the HPV vaccination rates among low income uninsured adult patients and ultimately prevent HPV related cancers. |
GERARDO COLON-OTERO; | 2020-10-19 |
| 426 | Proton Image-Guided Radiation Assignment for Therapeutic Escalation Via Selection of Locally Advanced Head and Neck Cancer Patients [PIRATES] PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase I trial studies the side effects of image-guided hyper-fractioned proton therapy in treating patients with head and neck cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be removed by surgery (unresectable). Radiation therapy uses high energy protons to kill tumor cells and shrink tumors. The change in dose radiation frequency and dose investigated in this study may help to better control the tumor and prevent it from coming back or growing. The goal of this study is to test a new radiation schedule that administers more radiation to the tumor tissue using image guided proton therapy for patients that have a high risk of having a tumor recurrence (the tumor comes back after treatment). |
CLIFTON D FULLER; | 2020-10-19 |
| 427 | Randomized, Placebo-controlled, Double-blind Study to Evaluate 2LPAPI® Efficacy on The Clearance of Genital HR-HPV Infections PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papillomavirus (HPV) is a prevalent pathogen, the epidemiology of which has mostly been studied in the uterine cervix and the vagina. The KCE Report 238Cs (2015) recommends HR-HPV-positive women should not be offered colposcopy immediately. Triage should be done using cytology for this purpose. If cytological abnormalities (ASCUS+) are found, immediate referral should follow for diagnosis and, where appropriate, treatment. If no abnormalities are observed in triage, … |
CATHERINE VAN PACHTERBEKE; | 2020-10-17 |
| 428 | Real-time Detection of CtDNA And/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC): The Pre-MERIDIAN (Molecular Residual Disease Interception in High-risk LA-HNSCC) Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research study will include patients with high risk locally advanced head and neck squamous cell carcinoma (LA-HNSCC) of the oral cavity, oropharynx, hypopharynx or larynx and patients that are starting on standard definitive treatment. Patients with both stage III HPV positive and stage III HPV negative will be included. In this study, we aim to evaluate feasibility of ctDNA and/or HPV DNA detection in real time in high-risk LA-HNSCC. |
LILLIAN SIU; | 2020-10-15 |
| 429 | Circulating HPV DNA in Cancers of The Anus and Uterine Cervix Treated With Definitive Radiation Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a research study for individuals who have cancer associated with human papillomavirus (HPV) and are being treated with radiation as part of standard care for their cancer. Doctors leading this study will use blood tests to find out if they can detect the HPV virus in the blood of study participants before, during, … |
CHRISTINA SON; | 2020-10-06 |
| 430 | Pilot Study of Induction Chemotherapy Followed By Risk and Response-Stratified Treatment for Locoregional HPV Associated Oropharyngeal Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Doctors leading this study will give blood tests to head and neck cancer participants during the beginning of chemotherapy treatment (also known as induction therapy) to see if these blood tests can help predict tumor shrinkage after therapy and reduce the amount of additional radiotherapy or chemotherapy treatment the participant may need. This study will also examine ways to reduce overall side effects of treatment using robotic surgery, chemotherapy and radiotherapy, or radiotherapy alone. |
ARI ROSENBERG; | 2020-10-01 |
| 431 | Evaluation of CIN2+ Rates Up to 120 Months After 48-Month Co-Testing (Long Term Follow Up of HPV FOCAL Participants) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: This FOCAL follow-up study aims to assess the long-term effectiveness and safety of primary HPV testing for cervical cancer screening. A cohort of participants from the original FOCAL study will be asked to see their health care provider to submit another cervical sample for cytology and HPV testing. This will permit evaluation of long term safety and effectiveness of primary HPV testing up to ten years after a participant’s first screening in the FOCAL study and comparison of primary HPV testing to HPV and cytology co-testing. |
GINA OGILVIE; | 2020-09-30 |
| 432 | A Phase 1/2 Study of AgenT-797 to Treat Moderate to Severe Acute Respiratory Syndrome Secondary to SARS-CoV-2 or Influenza PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A Phase 1/2 study of agenT-797 to treat moderate to severe acute respiratory distress syndrome (ARDS) secondary to acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or influenza. |
MINK THERAPEUTICS | 2020-09-21 |
| 433 | A Randomized, Double-Blind and Positive-Controlled Phase 3 Study to Evaluate The Immunogenicity and Safety of The 9-valent Human Papillomavirus (Types 6, 11, 16, 18,31,33,45,52 and 58) Recombinant Vaccine (Hansenula Polymorpha) in Chinese Female Subjects Aged16-26 Years PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will evaluate the immunogenicity and safety of 9-valent HPV recombinant vaccine in Chinese healthy females16 to 26 years of age. |
SHANGHAI BOVAX BIOTECHNOLOGY | 2020-09-19 |
| 434 | A Phase I-II, Open Label Study Evaluating The Safety and Efficacy of Alisertib and Pembrolizumab in Patients With Rb-Deficient Head and Neck Squamous Cell Carcinomas PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase I/II trial investigates the best dose and effect of alisertib in combination with pembrolizumab in treating patients with Rb-deficient head and neck squamous cell cancer. Alisertib may help block the growth of cancer.. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Giving alisertib in combination with pembrolizumab may help control Rb-deficient head and neck squamous cell cancer. HPV positive head and neck cancers are Rb-deficient. |
FAYE M JOHNSON; | 2020-09-15 |
| 435 | A Phase I Open Label, Dose Escalation Clinical Trial Assessing The Safety, Tolerability, and Feasibility of PNGVL4aCRTE6E7L2 HPV DNA Vaccine Administration Via Intramuscular TriGridTM Electroporation Delivery System to Patients With HPV16-Positive High-Grade Cervical Intraepithelial Neoplasia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary goal of this phase I open label study is to determine the safety and tolerability of pNGVL4aCRTE6E7L2 DNA vaccine, as administered by intramuscular (IM) injection with TriGrid™ electroporation to both HIV- or HIV+ adult female subjects (≥ 19 years), with biopsy confirmed cervical intraepithelial (CIN) II or III that is human papillomavirus (HPV) 16+. |
KIMBERLY LEVINSON; | 2020-09-14 |
| 436 | A Phase II Double Blind, Placebo-controlled, Randomized Trial of Artesunate Vaginal Inserts for The Treatment of Patients With Cervical Intraepithelial Neoplasia (CIN2/3) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II double blind, placebo-controlled, randomized study of Artesunate vaginal inserts for the treatment of women who have cervical high grade intraepithelial neoplasia (CIN2/3). |
GIUSEPPE DEL PRIORE; | 2020-09-09 |
| 437 | A Multicenter, Randomized, Double-Blind, Controlled (Bivalent Human Papillomavirus Vaccine (16,18 Type)(E. Coli)) Phase III Clinical Trial to Estimate Efficacy, Immunogenicity and Safty of The Recombinant Human Papillomavirus Vaccine (6,11,16,18,31,33,45,52,58 Type) (E.Coli) in Healthy Women Aged 18 to 45 Years PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase III clinical study was designed to evaluate the efficacy,immunogenicity and safety of Recombinant Human Papillomavirus Vaccine (6,11,16,18,31,33,45,52,58 Type)(E.Coli) manufactured by Xiamen Innovax Biotech CO., LTD., in healthy women aged 18-45 years old. |
JUN ZHANG; | 2020-09-05 |
| 438 | The Effect of Health Belıef Model Based Educatıon and Motıvatıonal Intervıewıng on Mothers’ Knowledge, Belıef and Attıtudes Towards Hpv Vaccıne PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research is a single-blind, randomized, parallel-controlled experimental study designed to determine the effect of Health Belief Model (SIM)-based motivational interviews given to mothers of high school students on mothers’ knowledge, beliefs and attitudes towards HPV vaccine. . The hypotheses of the research; The experimental group that received training and motivational interviews within the framework of SIM had higher knowledge and perception of HPV infection and vaccination in the posttest than the control group that did not receive any application. |
YASEMIN ATEŞEYAN; | 2020-09-01 |
| 439 | Quadrivalent and Bivalent Human Papilloma Virus Vaccines in The Treatment of Common Recalcitrant Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Warts are common, benign, epidermal proliferations caused by HPV infecting skin and mucous membranes. Treatment of warts poses a true challenge despite existing variable therapeutic modalities, whether destructive or immunotherapeutic. Human papilloma virus (HPV) vaccines are FDA approved for the prevention of genital warts and wart related precancerous and cancerous lesions but they are not indicated for treatment of preexisting warts yet |
HAGAR NOFAL; | 2020-09-01 |
| 440 | Anal Injury Screening for High Risk HPV in Population With Susceptibility to Anal Cancer Development PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The diagnosis of anal cancer is superior with the Anal Test system compared to liquid cytology and anoscopy. |
CARLOS E. ARANDA FLORES; | 2020-08-30 |
| 441 | A Study for Identification of Immune Determinants for Response to Nivolumab in Recurrent And/or Metastatic Head and Neck Squamous Cell Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A study for identification of immune determinants for response to Nivolumab in Recurrent /Metastatic HNSCC(Head and neck squamous cell carcinoma) patients. Recurrent and metastatic head and neck squamous cell carcinoma is incurable and requires aggressive treatment, resulting in functional disability, dismal prognosis, and high mortality rate. Prognosis of Recurrent and metastatic head and neck squamous cell carcinoma is poor, with limited treatment options and survival rates of 6-9 months following standard-of-care (SOC) therapies. Clinical trials have demonstrated promising clinical activity of anti PD-1(programmed death-1) therapy in head and neck squamous cell carcinoma. Currently, … |
HYE RYUN KIM; | 2020-08-30 |
| 442 | Intervention to Educate and Improve Underserved Populations’ Uptake and Completion of The HPV Vaccine Series PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The educational intervention to be delivered by the CHE(Community Health Educator) consists of toolkit education materials developed by the National Cancer Institute (NCI) and a small media intervention (i.e., video) that our research team has developed. The NCI-produced toolkit education materials consist of Power Point presentations, flyers, and posters that contain information about HPV(Human Papilloma Virus), HPV-related cancers, and the importance of the HPV vaccine series for adolescents (9-17 years old) and young adults (18-26 year old) who are eligible for the vaccine. |
EVELINN BORRAYO; | 2020-08-28 |
| 443 | Clinical Trial for Registration of HPV Nucleic Acid Genotyping Assay Kit PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to verify the clinical effectiveness of HPV Genotyping Nucleic Acid Assay Kit. This is a multi-center clinical study involving at least three study centers, each with screening sites. The protocol describes two study phases: Phase I is a baseline study of the screened population and ASCUS referral population (if necessary), the data of which will be submitted after the baseline study is completed; Phase II is a three-year follow-up study of the screened population, the data of which will be submitted again after the follow-up is completed. |
SHAOKAI ZHANG; | 2020-08-23 |
| 444 | Developing A Complete Cervical Cancer Screening Solution Based on First-void Urine Self-sampling: Validation for Detection of Precursor Lesions PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of the overall CASUS project is to develop the first fully molecular integrated cervical cancer screening approach, based on first-void urine as an easily accessible and non-invasive source of biomarkers. In contrast to current screening modalities, the CASUS approach will identify women with clinically relevant disease in need of treatment using only a single sample that can be collected at home (one-step triage). |
PIERRE VAN DAMME; | 2020-08-20 |
| 445 | Feasibility of The Enhanced Tobacco Intervention Protocol (ETIP) to Reduce Smoking and Potentially Alter The Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma and Non-Small Cell Lung Cancer PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial studies how well an enhanced tobacco intervention protocol (ETIP) works compared to standard treatment in helping head and neck and lung cancer patients starting treatment to reduce cigarette use. ETIP is an evidence-based tobacco cessation program including specialized one-to-one and telehealth counseling, drug therapy, nicotine replacement therapy, and frequent patient follow up. ETIP may help reduce smoking and improve cessation in patients with head and neck squamous cell cancer or non-small cell lung cancer. |
THOMAS JEFFERSON UNIVERSITY | 2020-08-19 |
| 446 | Phase I/II Trial of HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PD-L1/TGF-Beta Trap (M7824) in Subjects With HPV Positive Cancers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: For some cancers associated with human papillomavirus (HPV), standard treatments are not helpful. Researchers want to see if a vaccine for HPV combined with a drug called M7824 has a better effect on these cancers than when they work alone. Objective: To find a safe dose of HPV vaccine alone or combined with M7824. Also, … |
CHARALAMPOS FLOUDAS; | 2020-08-11 |
| 447 | A Phase I Study of Nelfinavir and Cisplatin Chemotherapy Concurrent With Pelvic Radiation for Locally Advanced Vulvar Cancer Not Amenable to Surgical Resection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase I trial studies the side effects and best dose of nelfinavir when given together with cisplatin and external beam radiation therapy in treating patients with vulvar cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be removed by surgery. Nelfinavir is an antiviral drug normally used to treat human immunodeficiency virus (HIV). Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, … |
LILIE L LIN; | 2020-08-07 |
| 448 | A Pilot Study of The Immunogenicity of A Two-dose Protocol for 9-valent Human Papilloma Virus Vaccination in Postpartum Girls and Women (15-45 Years Old) Previously Unvaccinated Against HPV PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The human papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the United States (U.S.) and is responsible for a wide range of conditions, including cancers within the anogenital tract and the oropharynx. In just the U.S. alone, it’s estimated that HPV causes 330,000 cases of precancerous cervical dysplasia and 12,000 cases of cervical cancer. The investigators propose a 2-dose HPV vaccination study in women seeking postpartum care at Johns Hopkins University. The investigators will measure the immunogenicity and acceptability of the vaccine in the postpartum setting. |
JENELL COLEMAN; | 2020-08-03 |
| 449 | CtDNA Liquid Biopsy for Early Assessment of Residual Disease in HPV-associated Head and Neck Cancer (Clear-HPVca) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test a new liquid biopsy assay for detecting residual disease after surgery in patients with HPV-associated head and neck cancer. |
DANIEL L. FADEN; | 2020-08-01 |
| 450 | The Relationship Between The Differences in Blood Cytokine Values and Disease Stage in Luminal A, Luminal B and Triple Negative Breast Cancers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: While classification of malignant breast tumors has traditionally been made according to their histological appearance, nowadays some subtypes have been defined according to their molecular features. The different behaviors of tumors in the luminal group necessitated the need to separate this group into luminal A and B subtypes. Luminal A group has the highest prevalence among breast cancers; It includes Her2 negative tumors with low proliferative activity, … |
UFUK OGUZ IDIZ; | 2020-08-01 |
| 451 | Naboth Kisti Ve HPV Pozitifliği Arasındaki Ilişkinin Araştırılması PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Aim of the study to asses the realition between HPV infection, Nabothian Cyst and Cervical Intraepithelial lesions or Cervical Cancer |
CIHAN COMBA; | 2020-07-23 |
| 452 | EFFECTIVENESS AND SAFETY OF THE MEDICAL DEVICES LOGUSGYN ,CANDIDEP (OVULI: LOGUSGYN OVULI – FLI.000003 /CANDIDEP OVULI – FEI.000404 AND LAVENDER: LOGUSGYN Lavender – FLI.000002 / CANDIDEP LAVENDER FEI.000409) IN THE TREATMENT OF NON-SPECIFIC VULVOVAGINITIS: RANDOMISED STUDY WITH 4-ARM SEQUENTIAL DESIGN’ PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate and compare the efficacy, activity and tolerability of a vaginal ova formulation containing tindalised cultures (Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus plantarum, Streptococcus thermophilus) (LOGUSGYN/CANDIDEP OVULES) and in vaginal lavage (LOGUSGYN/CANDIDEP LAVENDER) in patients with nonspecific vulvovaginitis compared to sterile saline-based vaginal irrigation (AELAV PURLING). The primary efficacy endpoint is based on the percentage of patients with therapeutic success, defined as resolution of signs and symptoms of vaginitis (total symptom score <4) at the end of treatment. For the overall assessment of clinical outcomes (resolution, ... |
FRANCESCO FORLEO; | 2020-07-17 |
| 453 | European VALidation of HUman Papillomavirus Assays and Collection DEvices for HPV Testing on Self-samples and Urine Samples PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The European VALHUDES study is a Clinical Performance /Diagnostic Test Accuracy Study that aims to evaluate whether HPV testing with new assays performed on self-samples, collected by means of a vaginal and a urine collection device is as accurate to detect cervical pre-cancer as on cliniciantaken cervical samples. |
MARC ARBYN; | 2020-07-16 |
| 454 | Clinical Validation of Cervical Cancer Screening Methods in St. Petersburg, Russia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This single-institution cross-sectional non-inferiority validation study evaluates alternative techniques and tests for primary cervical cancer screening programs in Russia, particularly: local cytology staining techniques, local HPV tests. |
N N PETROV NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY | 2020-07-13 |
| 455 | The Predictive Role of HPV Integration in HSIL and Cervical Cancer Related Papers Related Patents Related Grants Related Experts View Highlight: The stratified analysis by the level of HPV DNA integration in HSIL and cervical cancer will be drawn to explore whether the status of HPV integration makes any difference in the progression of cervical cancer. The purpose of the research is to reduce the miss of cervix lesions and prove that HPV integration detection is sensitive in cervical cancer precise screening. |
SHUANG LI; | 2020-07-07 |
| 456 | A Phase II Study of E7 TCR T Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer Related Papers Related Patents Related Grants Related Experts View Highlight: Background: The therapy used in this study is called E7 T-cell receptor (TCR) T cell therapy. This therapy is a type of treatment in which a participant’s T cells (a type of immune system cell) are changed in the laboratory to attack cancer cells. This treatment might help people with human papillomavirus (HPV)-associated oropharyngeal cancer. Oropharyngeal cancer is a type of head and neck cancer that happens in the oropharynx (the part of the throat at the back of the mouth, including the soft palate, the base of the tongue, … |
SCOTT NORBERG; | 2020-07-06 |
| 457 | A Novel Cervical Cancer Screen-and-Treat Demonstration Project With HPV Self-testing and Thermocoagulation for HIV-infected Women in Lilongwe Malawi PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess completion and performance of the following novel invasive cervical cancer (ICC) screen-and-treat algorithm among 625 HIV-positive women in Lilongwe, Malawi: 1) rapid testing of self-collected vaginal brush for primary high risk (hr)-human papillomavirus (HPV), 2) same-day visual inspection with acetic acid (VIA) for women who are hr-HPV positive, and 3) thermocoagulation for VIA positive/ablation-eligible (by cervical colposcopy) women. |
LAMECK CHINULA; | 2020-06-24 |
| 458 | Increasing HPV Vaccination Rates Through Virtual Immersive Communication Training on Recommending Immunizations: An Efficacy Study of VICTORI PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Our approach will be to implement Virtual Immersive Communication Training on Recommending Immunizations (VICTORI), an intervention that includes a self-directed app based curriculum and VR simulations, designed to increase the strength and consistency of HPV vaccine recommendations among clinicians. A single-site intervention assessing the efficacy of VICTORI in increasing HPV vaccine rates will be conducted. |
BRITTANY ROSEN; | 2020-06-23 |
| 459 | A Randomized, Blind, and Positive Control Design to Evaluate The Immunization Efficacy of 11 Valent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha) in Chinese Women Aged 18-26 Years PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A total of 480 Chinese women aged 18-26 years old were enrolle，experimental group and the control group were randomly assigned in a ratio of 3:1. 360 Chinese women in the experimental group and 120 in the control group. All subjects enrolled in the upper arm deltoid muscle were injected with 3 doses of test vaccine or control vaccine according to the 0, 2, and 6 months immunization program. |
NATIONAL VACCINE AND SERUM INSTITUTE CHINA | 2020-06-20 |
| 460 | Effect of N-Acetyl Cysteine (NAC) on The Oral Microbiome and on The Degree of Mucositis Developed in Response to Concurrent Chemotherapy and Radiotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of The Head and Neck Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase II treatment, randomized 3:1 ratio, open label clinical trial to study the effect of short duration administration of N-acetyl cysteine on oral microbiome and on mucositis caused by concurrent chemotherapy and radiotherapy. |
MERCEDES POROSNICU; | 2020-06-18 |
| 461 | HPV Serum Level and FDG PET CT in Patients With Cervical Cancer Treated With Radical Radiochemotherapy (HPV-RICCO – HPV Relation in Cervical Cancer Outcomes) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of the study is to describe changes in plasma HPV DNA levels in patients with locally advanced cervical cancer during radical radiochemotherapy (CRT) and to correlate changes with response to treatment. Monitoring of the response to treatment will also be assessed in FDG PET CT imaging. |
EWA BURCHARDT; | 2020-06-15 |
| 462 | An Open-label Multi-center Study of INO-3107 With Electroporation (EP) in Subjects With HPV-6- And/or HPV-11-associated Recurrent Respiratory Papillomatosis (RRP) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1/2 open-label, multicenter trial to evaluate the safety, tolerability, immunogenicity, and efficacy of INO-3107 in subjects with HPV-6 and/or HPV-11-associated recurrent respiratory papillomatosis (RRP). The trial population will include participants who have been diagnosed with either Juvenile-Onset RRP (J-O RRP) as defined by age at first diagnosis <12 years or with Adult- Onset RRP (A-O RRP) as defined by age at first diagnosis ≥12 years. A safety run-in will be performed with up to six participants with a one week waiting period between each enrolled participant. |
INOVIO PHARMACEUTICALS | 2020-06-15 |
| 463 | A Sequential Window of Opportunity Trial of Anti-PD-L1/TGF-beta Trap (M7824 ) Alone and in Combination With TriAd Vaccine, and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Some people who get head and neck cancer will need surgery to treat their cancer. Research suggests that immunotherapy drugs may help fight head and neck cancer if given before surgery. In most cases, there is enough time between cancer diagnosis and surgery to test immunotherapy drugs. In this study, researchers are testing the safety and anti-cancer abilities of 3 drugs given before surgery for head and neck cancer. Objective: To learn if giving M7824 alone, or with the TriAd Vaccine (ETBX-011, ETBX-051 \& ETBX-061), … |
HOYOUNG M. MAENG; | 2020-06-09 |
| 464 | Phase I/II Trial of Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: More than 30,000 cases of human papillomavirus (HPV) associated cancers occur annually in the United States. When these cancers spread, they do not respond well to standard treatments and are often incurable. Researchers want to see if a mix of drugs can help. Objective: To learn if a mix of immunotherapy drugs can shrink tumors in people with HPV associated cancers. Eligibility: People ages 18 and older with locally advanced or metastatic HPV associated cancer, such as cervical cancers; cyclin-dependent kinase inhibitor 2A (P16+) oropharyngeal cancers; anal cancers; vulvar, vaginal, penile, and squamous cell rectal cancers; … |
CHARALAMPOS FLOUDAS; | 2020-06-09 |
| 465 | Intraoperative HPV Testing Evaluation: Multicenter Prospective Cohort Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: High-grade intraepithelial lesion/cervical intraepithelial neoplasia grade 2-3 is a premalignant cervical lesion caused by persistent high-risk human papillomavirus infection. Human papillomavirus test is a very sensitive risk marker of cervical cancer and it has been incorporated in the follow-up after high-grade intraepithelial lesion treatment. Papillomavirus test performed intraoperatively could be a beneficial approach to anticipate treatment failure, allow for early management and consequently a reduction in costs. The aim of this study is to evaluate if the IOP-HPV test has non-inferior diagnostic utility of HSIL/CIN2-3 recurrence at 24 months as the HPV test performed 6 months after treatment. |
CRISTINA CENTENO MEDIAVILLA; | 2020-06-01 |
| 466 | Performance of HPV E4 and P16INK4a Biomarkers in Predicting Risk of Regression Among Women Diagnosed With Cervical Intraepithelial Neoplasia Grade 2 (CIN2): A Historical Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Introduction Cervical intraepithelial neoplasia CIN1 (low grade), CIN2 (moderate grade), CIN3 (severe grade) defines cervical precancer lesions derived from the squamous epithelial cell line. CIN2, represents a heterogenic phenotype expression of both CIN1-like and CIN3-like evolving lesions with different risk of progression. The CIN2 diagnosis has low reproducibility, and current diagnostic tools do not allow for risk-stratification of CIN2. Risk-profiling is important, to enable targeted management of women with CIN2 at first incidence (surgery or active surveillance) and to avoid risk of over- or undertreatment. Preliminary studies show, … |
UNIVERSITY OF AARHUS | 2020-06-01 |
| 467 | Contraception and Cervical and Breast Cancer Screening in Obese Versus Non-obese Women Aged 25 to 74 Years Old PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: .Brief Summary:* Obesity is a major public health problem in France. Indeed, 17% of the French population is obese (BMI greater than or equal to 30 kg/m²) while almost half of the adult population is overweight (BMI greater than or equal to 25 kg/m²). There is an increased risk of gynecological cancer in obese women but screening is less often performed : In women, obesity is a risk factor for the occurrence of certain cancers such as uterine cancer, epithelial ovarian cancer and breast cancer, particularly post-menopausal. In addition, … |
UNIVERSITY HOSPITAL MONTPELLIER | 2020-06-01 |
| 468 | A Comparative Study to Assess Efficacy of Intralesional MMR (Measles, Mumps, Rubella) Vaccine and Intralesional Vitamin D3 in Treatment of Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Common warts are papulonodular epidermal lesions caused by human papillomavirus (HPV) usually by the strains 1, 2, 4, 27 or 57. Cutaneous warts occur in 7% to 10% of the general population, … |
BIBISHA BAANIYA; | 2020-06-01 |
| 469 | Evaluate The Agreement of High-risk Human Papillomavirus Type Between Self-collected Vaginal Discharge Sample Using HygeiaTouch Self Sampling Kit for Woman and Physician Collected Sample From The Cervix PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Hygeia Touch Inc. developed a safe and comfortable vaginal self-sampling device Hygeia Touch Self Sampling Kit for Women to self-collect the vaginal discharge sample for high-risk Human Papillomavirus (hrHPV) detection. This clinical trial aimed to evaluate the agreement of hrHPV detections between vaginal self-sampling using Hygeia Touch Self Sampling Kit for Women and physician sampling, and these results will be applied for TFDA registration approval. |
HYGEIA TOUCH | 2020-05-29 |
| 470 | A Randomized, Double-Blind and Positive-Controlled Phase 3 Study to Evaluate The Immunogenicity and Safety of The 4-valent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine (Hansenula Polymorpha) and 9-valent Human Papillomavirus (Types 6, 11, 16, 18,31,33,45,52 and 58) Recombinant Vaccine (Hansenula Polymorpha) in Chinese Female Subjects Aged 20-45 Years PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will evaluate the immunogenicity and safety of 4-valent and 9-valent HPV recombinant vaccine in Chinese healthy females 20 to 45 years of age. |
SHANGHAI BOVAX BIOTECHNOLOGY | 2020-05-28 |
| 471 | A Phase I Study of E7 TCR T Cell Immunotherapy for High-Grade Cervical Intraepithelial Neoplasia Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Human papillomavirus (HPV) can lead to High-Grade Cervical Intraepithelial Neoplasia (CIN 2,3). This type of lesion has a high risk of becoming cancer. T cells are part of the immune system. A new type of treatment involves modifying these cells and injecting them into the lesions to shrink them. Objective: To test if injecting a type of treatment directly into cervical lesions can be safely given as therapy for high-grade CIN. Eligibility: People ages 21 and older with CIN 2,3 caused by HPV-16 Design: Participants will be screened over at least 2 visits with: Tumor sample Blood and urine tests Medical and medication history Physical exam Pelvic exam and colposcopy to look at the cervix Participants will have a baseline visit. They may be admitted to the hospital. They may receive a large catheter inserted into a vein. They will have a vein assessment. Before they receive treatment, participants will have a biopsy of the cervix. They will have leukapheresis. Blood will be removed through a needle in the arm, circulated through a machine that takes out the while blood cells, then returned through a needle in the other arm. A central catheter may also be used. Participants will have the modified cells injected directly into their cervical lesions. They will recover in the hospital for 1-2 days. Participants will have follow-up visits 2 weeks, 31 days, 6 weeks, and 12 weeks after treatment. They may receive a second injection at the 31-day visit. Participants will be contacted once a year for 5 years after treatment. They will be followed for up to 15 years. |
CHRISTIAN S HINRICHS; | 2020-05-28 |
| 472 | A Phase II Trial in Healthy Chinese Women Ages 20-45 to Evaluate The Immunogenicity and Safety Profile of Recombinant Nonavalent (Types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia Coli) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This trail is to evaluate the safety profile of Recombinant Nonavalent (Types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia Coli) in healthy Chinese women ages 20-45 and determine the optimal ratio of the antigens included in the investigational vaccine. Besides, the trail is also to demonstrate that the levels of neutralizing antibodies to vaccine HPV types 31, 33, 45, 52 and 58 elicited by the investigational vaccine with the chosen optimal antigen ratio are superior to those induced by Gardasil. |
BEIJING HEALTH GUARD BIOTECHNOLOGY | 2020-05-23 |
| 473 | Developing Methods to Investigate Additional Opportunities of HPV Vaccination, Including Control of Infection and Transmission, By Using A Cervicovaginal Human Sample, Collected By Urination (HPV-VACPLUS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study is to develop protocols using FV urine that investigate in vitro whether infectious virions can be neutralized by HPV vaccination. |
PIERRE VAN DAMME; | 2020-05-11 |
| 474 | Engaging Practices and Communities in The Development of Interventions to Promote HPV Vaccine Uptake PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The overarching goal of this project is to implement Boot Camp Translation (BCT) methodology to translate the guidelines and evidence for human papillomavirus (HPV) vaccine into a practice and provider level intervention designed to improve its acceptability and uptake. |
SEAN O’LEARY; | 2020-05-08 |
| 475 | A Study to Assess The Immunogenicity Consistency of Three Consecutive Batches of Commercial-scale of Recombinant Human Papillomavirus(HPV) Bivalent Vaccine (Escherichia Coli) in Healthy Female Subjects Aged 9-14 Years PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to evaluate lot-lot consistency of Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) . |
YUEMEI HU; | 2020-05-01 |
| 476 | Implementing HPV DNA Self-Collection to Increase Rates of Cervical Cancer Screening in Transgender Men PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Transgender men are individuals born genetically female that have a gender identity that is incongruent with their biological sex. For those who have begun or completed transition, they may present as males but still have a uterus and cervix. Thus far, no distinction has been made between routine cervical cancer screening guidelines in non-transgender women and those for transgender men, despite wide variations in sexual practices, including lifelong vaginal abstinence. The purpose of this study is to offer transgender men seen at clinic visits self-collected HPV testing to evaluate for improved cervical cancer screening rates, … |
AUGUSTA UNIVERSITY | 2020-05-01 |
| 477 | Immunogenicity, Compliance, Knowledge and Attitudes in Postpartum Women During A Two Dose 9-valent HPV Vaccination Series PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will evaluate the immunogenicity of the 9-valent HPV vaccine in post-partum women age 16-45. |
AUGUSTA UNIVERSITY | 2020-04-01 |
| 478 | Almitrine and Severe COVID-19 Patients in ICU [Almitrine Et Patients COVID-19 En Reanimation (French)] PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In severe COVID-19 pulmonary failure, the profound hypoxemia is mainly related to pulmonary vasodilation with altered hypoxic pulmonary vasoconstriction (HPV). Besides prone positioning, other non-ventilatory strategies may reduce the intrapulmonary shunt. This study has investigated almitrine, a pharmacological option used in standard care to improve oxygenation. A case control series of mechanically ventilated confirmed COVID-19 patients was recorded. At stable ventilatory settings, consecutive patients received two doses of almitrine (4 and 12 mcg/kg/min) at 30-45 min interval each, and were compared to 7 control COVID-matched patients conventionally treated. The end-point was the reduction of intra-pulmonary shunt, … |
MARIE REINE LOSSER; | 2020-03-20 |
| 479 | Primary Organoid Models and Combined Nucleic Acids Therapeutics for Innovative Anti-HPV Treatments in Cervico-vaginal Cancers and Precancerous Lesions PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Human papilloma virus (HPV) is responsible of the most common sexually transmitted infection. It can cause severe cancer lesions, of the cervix, vulva, vagina, penis and oropharynx. The International Agency for Cancer Research of World Health Organization (WHO) classified a dozen of HPV related high-risk cancer types, and recognized cervical cancer as the most common HPV-related disease. HPV 16 and 18 are responsible for 70% of cervical cancers. Due to the few symptoms of cervical cancer, women are often diagnosed with advanced state. Current treatments imply cervical conisation or hysterectomy, with or without lymphadenectomy and or radiotherapy, or chemotherapy. However, … |
SOUHAIL ALOUINI; | 2020-03-06 |
| 480 | Phase 2 Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate how effective the study drug IPI-549 is against types of cancers. IPI-549 is considered experimental because it is not approved by the US Food and Drug Administration (FDA) for the treatment of cancer. Patients will be treated with 3 weeks of IPI-549, a specific PI3Kγ inhibitor. Tumor tissue for research purposes through core biopsies will be obtained prior to initiation of IPI-549 and at surgery. |
EZRA COHEN; | 2020-03-06 |
| 481 | UNCPM 21904 – Prevention of Cervical Cancer Through An HPV-based Screen-and-treat Strategy in Malawi: A Cluster Randomized Trial PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine the acceptability, appropriateness, and feasibility of implementing new strategies to screen and treat eligible women for cervical cancer through a cluster randomized trial of two different models. Both models offer the same screening and treatment algorithm, but one will be based in Voluntary Family Planning (VFP) or other clinics and the second will be based in the community. Participants will be recruited from two districts in Malawi with the highest HIV prevalence in the country: Lilongwe in the Central Region and Zomba in the Southern Region. |
JENNIFER TANG; | 2020-03-04 |
| 482 | Identification of Circulating Tumor Cells in Patients With HPV 16 or 18 Associated Cervical Cancer Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a validation study to confirm the ability of Telomescan OBP-401 to identify CTCs in patients with HPV 16 / 18 associated cervical cancer. CTCs identified will be tested for the presence of the HPV 16 / 18 E6 protein, confirming a cervical cancer origin. |
LESLIE BOYD; | 2020-03-02 |
| 483 | Efficacy of Cryotherapy Combined With Intralesional Tuberculin Purified Protein Derivative (PPD) Versus Interlesional Tuberculin PPD Monotherapy in The Treatment of Multiple Common Warts PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigate the efficacy and safety of combined ‘cryo-immuno-therapy’ versus intralesional tuberculin purified protein derivative (PPD) antigen immunotherapy alone for multiple common warts |
HIBA A H ALSHAABY; | 2020-03-01 |
| 484 | A Phase 3, International, Multi-center, Randomized, Double-blind, Placebo-controlled Clinical Trial to Study The Efficacy, Immunogenicity, and Safety of The 9vHPV Vaccine, A Multivalent L1 Virus-like Particle Vaccine, in The Prevention of Oral Persistent Infection With HPV Types 16, 18, 31, 33, 45, 52, or 58 in Adult Males, 20 to 45 Years of Age PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy, immunogenicity and safety of the 9vHPV vaccine in men 20 to 45 years of age. The primary hypothesis tested after the primary database lock is that administration of a 3-dose regimen of 9vHPV vaccine will reduce the incidence of human papillomavirus (HPV) 16/18/31/33/45/52/58-related oral persistent infection (6 months or longer) compared with placebo. There will also be an Extension Study to offer an opportunity to complete the 3 dose regimen of 9vHPV vaccine for participants who received placebo in the Base Study, … |
MERCK SHARP & DOHME | 2020-02-27 |
| 485 | Stereotactic Boost and SHOrt-course Radiation Therapy for HPV-associated OroPharynx Cancer Trial: A Randomized Multicentric Phase II Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized clinical trial comparing the outcomes of short-course chemoradiation consisting in stereotactic boost to the gross tumor and de-esclalated chemoradiation to the elective neck in human papilloma associated oropharynx cancer vs. the current standard 7-week course chemoradiation. |
HOUDA BAHIG; | 2020-02-23 |
| 486 | A Community Based Program to Increase Breast and Cervical Cancer Screening and HPV Vaccination to Reduce The Impact of Breast and Cervical Cancer Among Latinas PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to increase early detection and prevention of breast and cervical cancer through education and navigation and to increase breast and cervical cancer screening and Human Papillomavirus (HPV) vaccination in underserved Latinas. |
LARA SAVAS; | 2020-02-20 |
| 487 | Evaluation of The Impact of Quebec HPV Immunization Program: Prevalence of HPV Types in 16-20 Year Old Males PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In Quebec, 18 birth cohorts of girls were vaccinated against HPV (aged 9 to 29 years in 2020). With an observed vaccination coverage of >80% an important herd effect might be expected. This study aim is to measure the HPV types prevalence in unvaccinated sexually active boys aged 16 to 20 years. |
CHANTAL SAUVAGEAU; | 2020-02-20 |
| 488 | Transoral Robotic Surgery for RECurrent Tumours of The Upper Aerodigestive Tract PF:3 Related Papers Related Patents Related Grants Related Experts View Abstract: Head and neck cancer (HNC) is the 6th most common type of cancer in the world and is increasing in incidence. Squamous cell carcinomas (SCC) account for the majority of these … |
ROYAL MARSDEN NHS FOUNDATION TRUST | 2020-02-14 |
| 489 | A Randomized Controlled Trial of Mailed Self-Sample HPV Testing to Increase Cervical Cancer Screening Participation Among Minority/Underserved Women in An Integrated Safety Net Healthcare System PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Regularly attending for Pap test cervical cancer screening in a clinic is often unfeasible and/or unacceptable to many women. This study evaluates if mailing and testing self-sampled kits for high-risk human papillomavirus (HPV) can cost-effectively increase screening participation among underserved minority women in a safety-net health system. |
JANE MONTEALEGRE; | 2020-02-13 |
| 490 | Immunogenicity and Safety of A 9-valent Human Papillomavirus Vaccine in HIV-positive Women PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In adult HIV-positive patients, data on the safety and immunogenicity of the quadrivalent HPV (qHPV) vaccine have been reported with excellent results (13 14); also, the results of a clinical trial of qHPV vaccine conducted in seropositive patients older than 36 years (WLHIV and MSM) have been published. Even now, there is not a trial about immunogenicity and safety of a 9-valent human papillomavirus vaccine in HIV-positive women; for this reason, … |
CARMEN HIDALGO TENORIO; | 2020-02-12 |
| 491 | Randomized Trial Evaluating Women’s Behavior Not Participating in Cervical Cancer Screening Facing Three Strategies for Optimizing Home Sending By Post of Vaginal Self-sampling Kit PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite the existence of an effective screening test (pap smear), cervical cancer is, every year in France, the cause of more than 3,000 new cases and 1,100 deaths. But, in France, 4 in 10 women are not screened or not often enough (nearly 7 millions women). It is therefore necessary to develop new strategies to reach these women. The etiological factor of this cancer is persistent infection with High-Risk Human PapillomaVirus (HR-HPV). Thereby, … |
JULIE BOYARD; | 2020-02-11 |
| 492 | TRICIN: Prospective Study on The Efficacy of Single Topical Trichloroacetic Acid (TCA) 85% in The Treatment of Cervical Intraepithelial Neoplasia (CIN 1/2) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Trichloroacetic acid 85% =TCA is an investigational device intended to achieve a complete histologic remission in individuals with cervical intraepithelial neoplasia (CIN) grade 1/2. The device system is to be used only in accordance with the approved Investigational Plan on subjects, who have given written informed consent. High remission and regression rates are expected after a single topical treatment with 85% TCA. After a single topical treatment with 85% TCA for CIN 1-2 (Expected 70% or higher; … |
LUKAS HEFLER; | 2020-02-07 |
| 493 | Impact of HPV Vaccination on The Distribution of HPV in High Grade Lesions of The Cervix in France PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective is to estimate the prevalence of the different genotypes of human papillomaviruses (HPV) in histologically proven high-grade lesions of the cervix in patients born between 1972 and 1993. It is plan to determine if the prevalence of HPV16 and HPV18 is lower in the population born between 1983 and 1993 and potentially exposed to HPV vaccination compared to those born between 1972 and 1982 who were not exposed to vaccination. Thus the investigators should be able to determine whether the introduction of HPV vaccination in France in 2007 has had an impact on the development of high-grade lesions associated with HPV16 and HPV18. |
JEAN-LUC PRETET; | 2020-02-01 |
| 494 | The Efficacy of Intralesional Measles, Mumps, Rubella (MMR) Vaccine, Intralesional Candidal Antigen and Topical Podophyllin in Treatment of Genital Warts: A Comparative Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study compares the safety and efficacy of intralesional Candidal antigen versus Intralesional MMR vaccine versus podophyllin for treatment of genital warts. |
MERIAM MAMDOUH BOSHRA; | 2020-02-01 |
| 495 | Randomized Controlled Trial of An Implementation Science Tool to Increase Cervical Cancer Screening in Mombasa, Kenya PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Cervical cancer is the most common cancer in women in sub-Saharan Africa, and the majority of cervical cancer mortality occur in low and middle income countries (LMICs). Many of the disparities between high and LMICs are attributed to differences in screening. Kenyan guidelines recommend screening with visual inspection methods followed by treatment of pre-cancerous lesions with cryotherapy and loop electrosurgical excision procedure (LEEP). Implementation of these are poor with only 14% of Kenyan women ever having been screened for cervical cancer as of 2014. To address this implementation gap, this application proposes three aims. In Aim 1, … |
MCKENNA EASTMENT; | 2020-01-29 |
| 496 | A Phase 1, Multicenter, Open-Label, Dose Escalation and Dose Expansion Study of SQZ-PBMC-HPV As Monotherapy and in Combination With Atezolizumab or Other Immune Checkpoint Inhibitors in HLA-A*02+ Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase 1 open-label, multicenter study of the safety and tolerability, immunogenic effects, antitumor activity, and pharmacodynamics of SQZ-PBMC-HPV as monotherapy and in combination with atezolizumab or other immune checkpoint inhibitors in HLA-A*02+ patients with recurrent, locally advanced or metastatic human papillomavirus strain 16 positive (HPV16+) solid tumors. The study includes patients with anal, rectal, cervical, head and neck, penile, vulvar, or vaginal cancer. |
SQZ BIOTECHNOLOGIES | 2020-01-28 |
| 497 | An Observational Study to Determine The Effects of Human Papillomavirus Diagnosis on Relationships of Head and Neck Cancer Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This trial studies the effects of human papillomavirus diagnosis on the relationships of patients with head and neck cancer. Determining the effects of human papillomavirus diagnosis on relationships may determine whether human papillomavirus-positive patients and their partners are more likely to experience decline in relationship intimacy after diagnosis than human papillomavirus-negative patients and their partners. This may help researchers provide valuable insight into the degree to which a diagnosis of human papillomavirus affects patient relationships over and above the effects of a cancer diagnosis and address the need for additional patient counseling or education following diagnosis. |
THOMAS JEFFERSON UNIVERSITY | 2020-01-24 |
| 498 | A Phase 1 Evaluation of The Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: People with Idiopathic CD4 lymphopenia (ICL) have lower numbers of a type of white blood cell called CD4 cells. White blood cells fight against infections. Low levels of CD4 cells may make a person more likely to get sick. There are no approved treatments for ICL. Researchers think a drug called belimumab may be able to help in specific situations. Objective: To see if belimumab is safe for people with ICL. Eligibility: People ages 18-70 who have ICL and are participating in NIH protocol 09-I-0102 (EPIC) Design: Participants will be screened with: Medical and medication history Physical exam Questionnaire about mental health and depression Blood and urine tests Participants will have a baseline visit. This will include some repeats of the screening tests. They may also have leukapheresis: Blood will be taken from a needle in one arm and passed through a machine that separates out the white blood cells. The rest of the blood will be returned through a needle in the other arm. Participants will receive 8 doses of belimumab through IV: A needle will insert a thin plastic tube into an arm vein. Belimumab will be given through the IV line. The first 3 doses will be given every 2 weeks. The other 5 will be given once every 4 weeks. Participants will have a physical exam and blood and urine tests at each dosing visit. They will be monitored for up to 4 hours after the infusion. Participants will have 3 follow-up visits, at around 8, 16, and 24 weeks after the last dose of belimumab. They will have a physical exam and blood and urine tests. Once they finish this protocol and they will continue to be followed under 09-I-0102 (EPIC study). |
IRINI SERETI; | 2020-01-13 |
| 499 | Papillomavirus Load in Rheumatic Inflammatory Diseases PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are the two most common chronic inflammatory rheumatism, with a prevalence in the French population of 0.3% and 0.4%, according to the criteria European League Against Rheumatism / American College of Rheumatology (EULAR / ACR) 2010 and Assessemnt of SpondyloArthritis International Society (ASAS) 2009 respectively. In patients whose pathology is resistant to first-line treatment, such as methotrexate for rheumatoid arthritis and peripheral spondyloarthritis, or non-steroidal anti-inflammatory drugs for axial spondyloarthritis, the treatment is based on biotherapies, such as anti-inflammatory drugs. -TNF, … |
FABIENNE COURY-LUCAS; | 2020-01-09 |
| 500 | Annual Anal Sampling Using DNA Screening to Identify Men Who Have Sex With Men at Increased Risk for Anal Cancer PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to find ways to screen for anal cancer among gay, bisexual, and other men who have sex with men (MSM) and transgender persons. This study will try to find out if persons will do annual anal cancer screening, what factors are associated with repeated screening, and how this affects a person’s decision to have high-resolution anoscopy. |
ALAN NYITRAY; | 2020-01-09 |