Clinical Digest: Recent Clinical Trials on Kidney Disease
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Kidney Disease. These trials are organized by their release dates for your convenience. (Last updated on: 2025-05-02)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Kidney Disease
| Clinical Trial | Contact(s) | Date | |
|---|---|---|---|
| 1 | The Prevention of Nephrotoxin-Induced Acute Kidney Injury Using Cilastatin (PONTiAK) Trial: A Phase 2B Vanguard Design, Randomized, Double-Blind, Placebo-Controlled Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to repurpose cilastatin for preventing acute kidney injury (AKI) in hospitalized patients receiving nephrotoxic medications. The trial will evaluate the efficacy of the re-purposed drug. The main questions it aims to answer are: – … |
MATTHEW JAMES; | 2025-05-01 |
| 2 | Point-of-Care Ultrasound-Guided Diuresis for Acute Decompensated Heart Failure to Reduce 30-Day Readmissions and Acute Kidney Injury PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure occurs when the heart cannot pump blood effectively, leading to fluid buildup in the body. This can cause problems such as difficulty breathing, swelling, and extreme tiredness. In severe cases, these symptoms worsen to the point where hospitalization is required. Unfortunately, many patients with severe heart failure are readmitted to the hospital within 30 days after discharge, which is both physically and emotionally challenging for patients and places a significant financial burden on individuals and the healthcare system. Although symptoms such as difficulty breathing and swelling may improve during the hospital stay, … |
JOHN PACELLA; | 2025-05-01 |
| 3 | A Randomized, Double-Blind, Multi-Regional, Phase 3 Study to Evaluate The Efficacy and Safety of AP301 on Serum Phosphorus Control in Chronic Kidney Disease Patients Receiving Maintenance Dialysis With Hyperphosphatemia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if AP301 could work in the patients receiving maintenance dialysis with elevated blood phosphate. The main questions it aims to answer are: * Does AP301 lower blood phosphate levels? * Does AP301 works on serum calcium level, calcium times phosphate level, … |
ALEBUND PHARMACEUTICALS | 2025-05-01 |
| 4 | Physical Activity in Adolescents With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this is to test the efficacy of a 12-week physical activity intervention in 64 adolescents with CKD. |
AMY KOGON; | 2025-05-01 |
| 5 | Femoral Versus Radial Artery Catheterization for Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients: The FERARI Randomized Superiority Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Acute circulatory failure, often presenting as arterial hypotension, is a major contributor to postoperative morbidity and mortality. Accurate blood pressure (BP) monitoring is essential for timely therapeutic intervention, particularly in patients undergoing major surgery. Among invasive BP measurement sites, the radial artery is commonly used due to its accessibility and ease of catheterization. However, physiologically, the radial artery may underestimate central arterial pressure compared to the femoral artery, … |
GUILLAUME BESCH; | 2025-05-01 |
| 6 | Feasibility and Pilot Testing of The My Heart and CKD Online Shared Decision Aid PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Many people with kidney disease also have heart disease. The procedures used to diagnose and treat heart disease (e.g., angiograms, angioplasty, or surgery) can improve symptoms and cardiovascular outcomes, … |
MATTHEW T JAMES; | 2025-05-01 |
| 7 | Predictors of Survival of DKD Patients in Assiut University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years, the global prevalence of diabetes has risen significantly. According to the 9th edition of the International Diabetes Federation Atlas, an estimated 463 million adults were living with diabetes in 2019, representing approximately 9.3% of the population, with an average annual increase of 51%. Diabetes is associated with multiple complications that can significantly impact patient outcomes . In 2019 alone, around 4.2 million deaths were attributed to diabetes and its complications, accounting for approximately 11.3% of all global deaths . In diabetic patients, several factors influence renal survival, including glycemic control, blood pressure management, lifestyle interventions, … |
HASNAA OSAMA HASSAN REIAD; | 2025-05-01 |
| 8 | Viscoelastic Tests (VET) Versus Conventional Coagulation Tests (CCT) for Management of Trauma-Induced Coagulopathy: Opened, Randomized, Two-Parallel, Controlled Trial.VISCOTAC PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Traumatic coagulopathy is a complex, multifactorial event that occurs in 20-30% of patients on admission. It increases mortality, and its treatment is one of the main priorities in the early management of severely injured patients. Diagnosis of coagulopathy has traditionally been based on conventional coagulation tests (CCTs), which provide an assessment of patients’ coagulation in over 60 minutes. Over the past fifteen years, viscoelastic tests (VETs) have been proposed, providing a more rapid result (≤ 10 min) and can guide the administration of labile blood products (LBP). Various studies, mainly retrospective, … |
HOSPICES CIVILS DE LYON | 2025-05-01 |
| 9 | A Randomized, Sham-controlled Pilot Trial of A Novel Therapeutic Strategy (taVNS) for Autonomic Nervous System (ANS) Dysfunction in Chronic Kidney Disease (CKD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 30 patients will participate in a prospective randomized clinical trial to test the safety, tolerability and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for autonomic nervous system (ANS) dysfunction in the chronic kidney disease (CKD) stage 3-5 setting. |
QANDEEL SOOMRO; | 2025-05-01 |
| 10 | Randomized Control Trial Evaluating The Impact of CGM Academy Education Curriculum Versus Standard Care on Glycemic Outcomes for Youth With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this randomized clinical trial is to compare the effects of a virtual education curriculum in blood glucose variation of youth with type 1 diabetes wearing continuous glucose monitoring (CGM) device. The main questions the study aims to answer are: * Do participants undertaking the proposed curriculum present improved glucose variation than participants of standard education? * Explore relationships between participant’s glycemic outcomes with diabetes distress, diabetes family responsibilities, … |
REBECCA BARBER; | 2025-05-01 |
| 11 | Six Minutes Walk Test in Children on Regular Hemodialysis at Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate exercise tolerance and the reproducibility of the six minute walk test in children and adolescents with ESRD on regular hemodialysis and to compare their functional exercise capacities with reference values for healthy children. To investigate predictors of poor 6MWT performance in children on regular HD |
CAROLINE FAYEZ ABDELMALAK; | 2025-05-01 |
| 12 | Suitability of Two Flavours of A High-energy, Low-protein Formula (Renalive® LP) in Chronic Kidney Disease Stage 3b-5 Outpatients in Taiwan PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose of study To evaluate suitability of two flavours of a high energy low protein formula (Renalive® LP) as oral nutritional supplement and meal replacement in chronic kidney disease stage 3b-5 outpatients Inclusion criteria (1) Diagnosed with chronic kidney disease stage 3b-5 (with history of eGFR\<45 mL/min/1.73 m2) (2) Age: 18-80 years (3) Outpatients with instruction to keep a low protein diet (0.55-0.8 g protein /kg actual body weight/ day) in the last 3 months as evaluated by the Investigator. (4) Written Informed Consent from patient. Exclusion criteria 1. Has received dialysis or are expected to start dialysis within the next 3 months. 2. Patients awaiting kidney transplant. 3. Body mass index (BMI) \<18 kg/m2 or BMI \>30 kg/m2 4. Malnourished patients with albumin \<3 g/dL in need of extra calories and nutrients 5. Patients receiving or having received oral/enteral/parenteral nutrition supplementation for special medical purpose in the last 28 days 6. Severe liver disease, malignant neoplastic disease, current significant infectious disease (apart from flu, cold, Hepatitis C virus (HCV) carrier, Hepatitis B virus (HBV) carrier, skin infection) deemed unsuitable for entering the trial as evaluated by the Investigator 7. Existing gastrointestinal disease or pathological findings that cannot tolerate enteral nutrition or render enteral nutrition unfeasible, such as shock, acute upper gastrointestinal bleeding, intestinal sluggishness, intestinal obstruction, or malabsorption, such as inflammatory bowel disease, pancreatic disease, or gastrointestinal surgery 8. Severe impairment of gastrointestinal function, i.e. severe constipation or acute diarrhoea (≥3 loose or watery stools a day) 9. Swallowing difficulty or high risk of aspiration 10. Central nervous system and/or certain psychiatric disorders where the patient is considered as not yet clinically stable and/or not suitable to participate in this study by the Investigator 11. Known allergic reaction or intolerance to any ingredient of the intervention formula. 12. Surgery or hospitalization scheduled during the trial 13. Suspected drug abuse 14. Unable to follow study instructions or keep a dietary diary 15. Pregnant or lactating women 16. Participation in other clinical trials using investigational drugs within 30 days before the start of the trial or during the trial. Primary Endpoint (1) Change in body weight from Baseline to end of treatment at Week 4 (Week 4 - Baseline) Secondary Endpoints 1. Daily dietary intake of energy, protein, sodium, potassium, magnesium, phosphorus, and calcium at Baseline, Week 2 and 4 based on a 3-Day Dietary Record 2. Change of nutritional status using body weight, BMI, and body composition as indicators: * Change in body weight from Baseline to Week 2 * Change in BMI from Baseline to Week 2 and week 4 * Change in body composition from Baseline to Week 4 using bioelectrical impedance assessment 3. Change of the physical performance using hand grip strength as an indicator from Baseline to Week 4 4. Change of renal function: * Change in estimated glomerular filtration rate (eGFR) (Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\]) from Baseline to Week 4 * Change in blood urea nitrogen and serum creatinine from Baseline to Week 2 and 4 5. Serum albumin and pre-albumin at Baseline and Week 4 6. Blood electrolytes (sodium, potassium, phosphorus, calcium, magnesium) at Baseline, Week 2 and 4 7. Serum C-reactive protein (CRP) at Baseline, Week 2 and 4 8. Compliance rate (%) to Renalive® LP |
FRESENIUS KABI TAIWAN | 2025-05-01 |
| 13 | Enhancing Physical Function in Older Adults With Chronic Kidney Disease (EPIC): A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to: 1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD. 2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD. |
ELIOTT ARROYO; | 2025-05-01 |
| 14 | Characterising The Loss of Haemostasis in Haemorrhagic Fever With Renal Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hantaviruses are globally distributed viruses that cause haemorrhagic fever with renal syndrome (HFRS) in Europe, a disease characterised by acute kidney failure and, in some cases, significant bleeding complications. The mechanisms underlying clotting abnormalities in HFRS remain poorly understood. This study aims to investigate the pathological mechanisms of clotting dysfunction in hospitalised HFRS patients, assess the impact of different hantavirus types on disease severity, and evaluate the accuracy of a severity scoring system developed in China for predicting mortality in European patients. Hospitalised patients with laboratory-confirmed HFRS will be prospectively recruited from University Medical Centre Ljubljana, … |
LIVERPOOL SCHOOL OF TROPICAL MEDICINE | 2025-05-01 |
| 15 | A Comparison of Renal Vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute kidney injury (AKI) is a complication of cardiac surgery that can affect outcome. Near Infrared Spectroscopy (NIRS) is a technology that uses light to determine how well oxygenated tissues are. This technology is routinely used in cardiac surgery to measure the oxygen level in the brain by placing a sensor sticker on the forehead. The purpose of the study is to determine whether NIRS sensor stickers placed on the skin over the kidney can predict AKI better than when sensors are placed on the skin over the participant’s limbs. This study is being conducted by investigators from the department of anesthesiology at the University of Utah. |
NATALIE SILVERTON; | 2025-04-30 |
| 16 | A Multicentre, Randomised, Double-blind, Active-Controlled, 2-arm Parallel-group Treatment, Phase II Study to Evaluate The Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin Alone in Adult Participants With Chronic Kidney Disease and High Proteinuria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A Study to Investigate the Effects of Zibotentan/Dapagliflozin Combination Compared to Dapagliflozin Alone in Adult Participants with Chronic Kidney Disease and High Proteinuria (ZODIAC) |
ASTRAZENECA | 2025-04-28 |
| 17 | Cross-sectional Study on The Early Detection of Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This retrospective observational study aims to assess the proportion of patients who were appropriately referred from primary care to the nephrology teleconsultation service. The appropriateness of the referral will be determined by the time elapsed between the referral criteria being met and the date of the teleconsultation, as well as by the patient’s treatment at the time of referral. |
IGNACIO MANZUR; | 2025-04-22 |
| 18 | A Phase I, Randomised, Investigator- and Participant-blinded, Placebo-Controlled, Study to Assess The Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the safety and tolerability, and pharmacodynamics (PD) of AZD4144 administered as repeated daily oral dosing. |
ASTRAZENECA | 2025-04-22 |
| 19 | Prevalence and Risk Factors of Hyperkalemia in Non-Dialysis Chronic Kidney Disease Patients in A Community-Based Primary Care Setting PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate the prevalence and risk factors of hyperkalemia in community-based non-dialysis chronic kidney disease (CKD) patients. The main questions it aims to answer are: 1. What is the prevalence of hyperkalemia in non-dialysis CKD patients in a primary care setting? 2. What are the key risk factors influencing the occurrence of hyperkalemia in this population? Researchers will collect clinical and demographic data from participants across 18 community health centers and use both point-of-care testing (POCT) and laboratory-based methods to measure serum potassium levels and related parameters. Participants will: 1. Provide blood samples for POCT and laboratory testing. 2. Participate in interviews or questionnaires to gather clinical and lifestyle information. The findings will be used to construct a risk prediction model for hyperkalemia, aiming to optimize screening pathways and improve disease management strategies in primary care. |
XIUJUAN ZANG; | 2025-04-20 |
| 20 | Staging Heart Failure With Preserved Ejection Fraction By Assessing Cardiac Chamber Involvement With Echocardiography PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure with preserved ejection fraction (HFpEF) is considered a systemic condition in which the prevalence of cardiovascular, metabolic, pulmonary and renal conditions determine the extent of cardiac involvement. Numerous attempts have been made to phenotype HFpEF, but we still lack a clinically and/or prognostically relevant approach. Progressive cardiac deterioration in HFpEF appears to be associated with a worse prognosis. However, no attempt has been made to classify the extent of cardiac involvement in HFpEF. We proposed the concept of HFpEF staging according to the extent of cardiac involvement identified by transthoracic echocardiography: Stage 1: isolated left ventricular involvement; … |
ANASTASIA SHCHENDRYGINA; | 2025-04-20 |
| 21 | Long-term Follow-up to Determine Outcome in Liver Disease (LOVE Study) PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The rational to conduct the LOVE study builds on the lack of available data on outcomes in steatotic liver disease in well characterized patients over a time frame of several years. At current limited data on liver-specific and overall outcome in patients with MASLD, MetALD and ALD are available. Liver histology is the only accepted surrogate to reasonably likely predict outcomes in patients with non-cirrhotic liver disease and is currently used in regulatory trials. To overcome the limitations of liver biopsy and use validated non-invasive tests (NITs) to predict outcomes, … |
UNIVERSITÄT DES SAARLANDES | 2025-04-15 |
| 22 | Exploring The Potential Effect of Pentoxifylline in Mitigating Vascular Calcification in Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is research to find out if the drug pentoxifylline can help prevent or lessen the problem of blood vessel hardening (vascular calcification) in people with chronic kidney disease (CKD). People with CKD are at higher risk for heart problems and blood vessel hardening. Vascular calcification happens when calcium builds up in the blood vessels, making them stiff. Pentoxifylline is a drug that might have helpful effects that could reduce this hardening. In this study, some CKD patients will receive pentoxifylline in addition to their usual medications, … |
DINA MASSOUD GABER; | 2025-04-15 |
| 23 | Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Kidney transplantation (KT) benefit-risk ratio assessment is a challenge in a growing population of older patients with end-stage kidney disease. A pre-KT frailty phenotype has been found predictive of post-KT complications, but biological mechanisms of frailty are poorly known is these patients. Frailty is associated with chronic low-grade inflammation in the older general population, possibly through the inflammasome pathway. Our main objective is to assess if systemic activation of inflammasomes is associated with frailty in older candidates to KT. |
FLORENT GUERVILLE; | 2025-04-15 |
| 24 | Effect of Roxadustat on Bone and Neuropsychiatric Aspects in End Stage Kidney Disease Patients on Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: People with severe kidney failure who need regular hemodialysis treatment often experience several health problems. These include anemia (low red blood cell count), issues with their bone health (sometimes called mineral and bone disease), and mental health challenges like depression and anxiety. They may also have problems with their nerves and muscles. Roxadustat is a newer medicine, taken as a pill, used to treat anemia caused by kidney disease. It works differently than the standard injectable medications often used. This study aims to investigate if Roxadustat has effects beyond treating anemia in hemodialysis patients. Specifically, … |
MOSTAFA IBRAHIM ALSAYED ALASKARY; | 2025-04-15 |
| 25 | Proteomic Analysis of Amniotic Fluid to Predict Postnatal Renal Function in Fetuses With Renal and Urinary Tract Malformations PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this project is to validate a previously established amniotic fluid 98 peptide signature predictive of post-natal outcome in fetuses with congenital anomalies of the kidney and the urinary tract (CAKUT) in a real clinical context. It includes the feasibility of collecting, transporting and analyzing the amniotic fluid peptidome from clinical centers all over France and of providing the result in a clinically accepted time-frame. Therefore, this multicenter study will not only allow to determine the added value of such new prenatal test but also to ensure the feasibility of its introduction in the management of CAKUT pregnancies. |
UNIVERSITY HOSPITAL TOULOUSE | 2025-04-15 |
| 26 | SCARR: Allogeneic Umbilical Cord Mesenchymal Stromal Cells for The Treatment of Chronic Antibody-Mediated Rejection (cABMR) in Kidney Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Kidney transplantation is the best treatment for end-stage chronic kidney disease (CKD), improving survival and quality of life, while reducing treatment costs. However, immunosuppressive therapies reduce acute rejection but have not significantly improved graft survival (60% at 10 years). Graft loss is largely due to chronic antibody-mediated rejection (cABMR), which remains a major challenge with no specific treatment. In our center, 20 cABMR cases confirmed by biopsy were identified in 2018-2019, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-04-15 |
| 27 | Effect of Low Versus High Dialysate Sodium Concentration During Hemodialysis on Dialysis Recovery Time: A Prospective Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research aims to assess the effect of low versus high dialysate sodium concentration during hemodialysis on dialysis recovery time |
MOHAMED MAMDOUH MAHMOUD MOHAMED ELSAYED; | 2025-04-15 |
| 28 | Multicenter Study of 18F-Labeled NY104 for PET/CT Imaging in Renal Cell Carcinoma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Study on the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-NY104 PET/CT in diagnosing primary, recurrent, and metastatic lesions of renal cell carcinoma; and investigate the effect of oral low-dose CAIX inhibitor (Acetazolamide) on the tissue distribution of 18F-NY104 in renal cell carcinoma patients, particularly in the stomach and kidneys. |
THE AFFILIATED HOSPITAL OF QINGDAO UNIVERSITY | 2025-04-12 |
| 29 | Effect of Long-Term Use of Tenofovir (TDF) on Renal Function in Patients With Chronic Hepatitis B PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Effect of Long-Term Use of Tenofovir (TDF) on Renal Function in Patients with Chronic Hepatitis B Over a Five-Year Period |
NOUR SHAABAN MOHAMED ABD ELRASOUL; | 2025-04-10 |
| 30 | Bee Venom As Immunomodulator and Its Effect on Chronic Kidney Disease-Mineral Bone Disorders in Hemodialysis Patients: A Prospective Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the effectiveness of bee venom injections as a treatment for chronic kidney disease (CKD)-mineral bone disorder (MBD) in patients undergoing hemodialysis. MBD is a common complication in CKD patients, leading to abnormal mineral metabolism, bone disease, and increased cardiovascular risks. Current treatments are often inadequate and can have significant side effects. In this study, we will compare the effects of bee venom injections with standard care treatments in hemodialysis patients. Bee venom is known for its potential anti-inflammatory and immunomodulatory properties, … |
ISLAM MOHAMMED AHMED ABOALELA; | 2025-04-10 |
| 31 | Non-invasive Evaluation of Kidneys in Patient With Congenital Anomalies of The Kidney and Urinary Tract (CAKUT) Using Ultrasound Localization Microscopy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical study aims to non-invasively visualize perfusion and microvascularization, as well as individual glomeruli, using Ultrasound Localization Microscopy (ULM) and CEUS in patients with congenital anomalies of the kidney and urinary tract (CAKUT). |
FERDINAND KNIELING; | 2025-04-05 |
| 32 | Expanded Access Treatment Protocol for R007 (Probucol) Tablets in Adults With Genetically-Confirmed Mitochondrial Disease and Chronic Kidney Disease (Intermediate-Size Patient Population) Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this expanded access program is to enable access to R007 (probucol) tablets for the compassionate treatment of adults with mitochondrial disease who also have chronic kidney disease. |
ZARAZUELA ZOLKIPLI-CUNNINGHAM; | 2025-04-04 |
| 33 | Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters (BTK Multicath Registry) A non-randomized clinical registry This study is designed to obtain preliminary data on clinically relevant procedural variables during percutaneous below-knee artery revascularization procedures among consecutive patients treated with either the Finesse BTK Multicath® (Finesse) or the standard of care using conventional angioplasty balloon catheters. This registry will enroll participants with a history of chronic limb threatening ischemia and below-knee arterial insufficiency who will be assigned to revascularization with or without use of the Finesse BTK Multicath. The registry is an acute study examining procedural data only. The primary endpoints of interest are the volume of contrast used for the intervention, overall procedure time, radiation dose, number of catheter exchanges during revascularization, and medical device supply costs. For the first phase 12 consecutive patients will be treated with the standard of care. For the second phase 12 consecutive patients will be treated with Finesse. 24 participants total Up to 5 study sites in the United States Initial anticipated enrollment: Q4 2024 Last anticipated enrollment: Q2 2025 Patients \>=18 years old with documented history of unilateral chronic limb threatening ischemia due to below-knee arterial insufficiency with angiographic runoff in the foot and limited arterial insufficiency above the knee 1. Contrast volume administered during the revascularization portion of a procedure. 2. Number of catheter exchanges during revascularization 3. Fluoroscopy time 4. Radiation dose during revascularization 5. Procedure time post-enrollment 6. Equipment costs 7. Reduced use of supplies 8. Technical success 9. Safety/Major Adverse Peripheral Events On-treatment sample Intention-to-treat |
SUMMA THERAPEUTICS | 2025-04-03 |
| 34 | Effects of Probiotic Supplementation on Disease Progression in Patients with Moderate to Severe Chronic Kidney Disease: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn whether probiotic supplementation can slow disease progression in patients with moderate to severe chronic kidney disease (CKD). The trial will also assess the safety of probiotics in these patients. The main questions the study aims to answer are: Does probiotic supplementation improve kidney function by reducing serum creatinine levels and protein in urine? Does it reduce inflammation and metabolic imbalances in CKD patients? Does it affect gut microbiota composition and lower harmful toxins in the body? Is probiotic supplementation safe and well-tolerated in CKD patients? Participants will: Be randomly assigned to receive either probiotics or a placebo for 6 months. Have clinic visits every 6 months for checkups, blood tests, and urine tests. Be monitored for any side effects and changes in kidney function. Researchers will compare the probiotic group to the placebo group to determine whether probiotics are effective in slowing CKD progression. |
SAMAR ELSHAHAT SALEH; | 2025-04-03 |
| 35 | Norepinephrine Vs Phenylephrine As The First-line Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-cardiac Surgery PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery. Anesthesiologists commonly administer medications called vasopressors to treat low blood pressure during surgery. These medications help raise the blood pressure back up to a safe range. Two vasopressor medications are commonly used for this purpose: norepinephrine and phenylephrine. Each of these medications has slightly different effects on the heart and blood vessels (cardiovascular system). It remains unknown which of these standard medications is better for treating low blood pressure during surgery. The goal of this clinical trial is to determine which of these two medications is better at preventing injury to the kidneys after major noncardiac surgery as well as other complications such as heart problems. Major surgeries are defined as those lasting at least two hours under general anesthesia. This trial will randomize about ten centers in North America to use either norepinephrine or phenylephrine as the primary medication to treat low blood pressure in adults undergoing major noncardiac surgery. Each hospital will prioritize one of the drugs each month, and the assigned drug will rotate each month at each hospital. No further participant involvement will be required as de-identified data are collected as part of standard medical care. |
SACHIN KHETERPAL; | 2025-04-01 |
| 36 | Dial-Bicarb Trial: Effects of A Lower Vs. Higher Concentration of Dialysate Bicarbonate for People Receiving Maintenance Hemodialysis PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pragmatic, two-arm, parallel-group, open-label, individual-randomized, superiority trial that will be conducted in hemodialysis units across Ontario. Patients at each dialysis unit will be randomly allocated into one of two study arms in a 1:1 ratio to receive a dialysate bicarbonate concentration of either 32 or 38 mmol/L. The intervention will be embedded into routine care and delivered by hemodialysis unit personnel. |
AMIT GARG; | 2025-04-01 |
| 37 | The Effect of Critical Ultrasonography Guided Precise Fluid Management in Patients With Sepsis or Septic Shock: A Single-center Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess whether procedural critical ultrasonography guided precise fluid management (CUGP) can affect the clinical fluid management strategy and improve the outcomes of patients with sepsis or septic shock. |
SHUSHENG LI; | 2025-04-01 |
| 38 | Assessemnt of The Knoweldge ,Attitudes and Practices of Diabetic Kidney Disease Among Diabetic Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This research aims to evaluate the levels of knowledge , attitudes and practices, of diabetic kidney disease among diabetic patients. |
SARA ABDELAZIZ HASSAN MAHMOUD; | 2025-04-01 |
| 39 | Evaluation of Plasma Renin Concentrations in Cardiac Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery. Renin is a protein that may be elevated in response to low blood pressure or situations where organs do not receive sufficient oxygen. Renin may potentially be used as an indicator for specific treatments aimed to increase the blood pressure. This study will evaluate blood samples for renin concentration throughout the course of open heart surgery. |
PATRICK M. WIERUSZEWSKI; | 2025-04-01 |
| 40 | Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Heart failure (HF) is a severe cardiovascular disease with extremely high morbidity and mortality rates worldwide, and ischemic cardiomyopathy is an important cause of heart failure. Vericiguat is a soluble guanylate cyclase stimulator which has been verified to improve the cardiovascular outcomes in heart failure patients. The VICTORIA trial excluded patients with acute coronary syndrome in 3 months prior to the study start, so it is still unclear about the efficacy and safety of vericiguat in heart failure after acute myocardial infarction. So we conducted this multi-center, prospective, … |
DONGYING ZHANG; | 2025-04-01 |
| 41 | Comparative Safety Analysis: PET Vs. CT Scans During Intensive Care Admission PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to assess how safe it is for critically ill patients in the Intensive Care Unit (ICU) to undergo a PET scan. A PET scan is a type of medical imaging used to help determine why a patient is sick. It is similar to a CT scan but involves a small amount of radioactivity to highlight areas of concern in the body. For a PET scan, patients need to be transported from the ICU to the scanning room, … |
UNIVERSITY MEDICAL CENTER GRONINGEN | 2025-04-01 |
| 42 | Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: * To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients. * To evaluate the short-term outcomes of those patients. |
AHMED RADWAN RIAD; | 2025-04-01 |
| 43 | A Trial Investigating The Efficacy and Safety of LC-Z300-01 on Proteinuria in Patients With Diabetic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this RCT is to investigate the efficacy and safety of Sugar cane polysaccharide LC-Z300-01 on proteinuria in participants with diabetic kidney disease (DKD). |
SHANGHAI CHANGZHENG HOSPITAL | 2025-04-01 |
| 44 | An Open-Label, Two-Arm (DefenCath® Vs. Institutional Standard of Care) Study to Assess Safety and Time to Catheter-related Bloodstream Infections (CRBSI) in Subjects From Birth to Less Than 18 Years of Age With Kidney Failure Receiving Hemodialysis Via A Central Venous Catheter PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a post-marketing approval requirement to assess the safety and time to Catheter-related Bloodstream Infections (CRBSI) of DefenCath in pediatric population (birth to less than 18 years of age) who are on chronic HD for kidney failure. |
CORMEDIX | 2025-04-01 |
| 45 | Diuretic Testing in Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to predict the progression of chronic kidney disease by diuretic testing in patients with chronic kidney disease. The main questions it aims to answer are: Does a worse result of a diuretic test predict the progression of chronic kidney disease? If there is a comparison group: Researchers will compare the diuretic test in patients with chronic kidney disease to healthy participants to see if the results are different in a healthy kidney. Participants will undergo diuretic testing. This involves the administration of bumetanide and hydrochlorothiazide with subsequent blood and urine collections. |
EWOUT HOORN; | 2025-04-01 |
| 46 | Efficacy and Safety of Activated Charcoal on Mineral Bone Disorder in Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hyperphosphatemia management is initially based on restricting dietary phosphorus intake. Hyperphosphatemia is almost always seen in patients on dialysis and may contribute to progressive vascular calcification. Considering that activated charcoal is generally well-tolerated and may have a favorable side effect profile compared to conventional phosphate binders, it presents a promising alternative. Until now, no clinical trial has primarily investigated the effect of activated charcoal on hyperphosphatemia in dialysis patients. |
NOHA MANSOUR; | 2025-04-01 |
| 47 | Clinical Study Evaluating The Impact of Dapagliflozin on Erythropoiesis-Stimulating Agent Responsiveness in Anemic Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, primarily used in the management of type 2 diabetes mellitus. Emerging research suggests that SGLT2 inhibitors may offer additional benefits, including reducing the risk of cardiovascular events and renal complications. Post hoc analyses of previous clinical trials have shown that patients treated with SGLT2 inhibitors exhibited higher levels of hemoglobin and hematocrit compared to those in the control group. These findings suggest that dapagliflozin’s ability to elevate hemoglobin levels could potentially be utilized for the treatment of anemia in patients with chronic kidney disease. |
NOHA MANSOUR; | 2025-04-01 |
| 48 | The Efficacy and Safety of Dapagliflozin in The Treatment of Hereditary Kidney Disease With Proteinuria in Children: A Prospective, Randomized Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter, randomized controlled crossover trial aimed to evaluate the efficacy and safety of dapagliflozin in the treatment of hereditary kidney disease with proteinuria in children |
YIHUI ZHAI; | 2025-03-21 |
| 49 | Staged Kidney Transplantation During Combined Heart/Kidney Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this study is to evaluate the safety and efficacy of ex vivo machine perfusion with staged implantation of kidney allografts during combined heart/kidney transplantation. |
JUSTIN STEGGERDA; | 2025-03-18 |
| 50 | The Effects of Transcutaneous Laser Therapy in Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) affects approximately 10% of the global population, totaling over 800 million people. In Taiwan, one in eight individuals is diagnosed with CKD. According to National Health Insurance data, acute kidney injury and CKD rank first in medical expenditures, imposing a significant burden on patients’ quality of life and the national healthcare system. Early intervention in CKD, especially for high-risk populations (e.g., individuals with diabetes or early-stage kidney dysfunction), can slow disease progression, delay the onset of kidney failure, … |
CHENG-FENG LIN; | 2025-03-17 |
| 51 | The Effect of Home-based Exercise on Postural Abnormalities of Dialysis Patient PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study evaluates the effects of synchronous home-based tele-exercise on postural abnormalities (FHP and hyper-kyphosis) in dialysis patients. It aims to assess improvements in balance, physical function, and quality of life while reducing fatigue and fall risk. |
MOHAMMAD ALI TABIBI; | 2025-03-15 |
| 52 | EAGLE-HF Is Part of A Multinational Group of Studies Titled; Screening for Early Heart Failure Diagnosis and Management in Primary Care or at Home Using Natriuretic Peptides and Echocardiography PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: EAGLE-HF (Early Assessment and initiation of GuideLine-directed Evidence-based management-HF) is a prospective single site study of a multinational, unblinded, randomized-controlled, longitudinal trial called SYMPHONY. Primary, secondary and exploratory outcomes that are part of SYMPHONY are not described herein as they replicate SYMPHONY outcomes. Data associated with SYMPHONY outcomes will be sent to the SYMPHONY coordinating center. In EAGLE-HF, site investigators will examine if a new-onset heart failure (HF) diagnosis are asscoiated with social determinants of health (6 factors), social vulnerability index and distressed community indices. In addition, for patients diagnosed with HFrEF, … |
NANCY M. ALBERT; | 2025-03-11 |
| 53 | Advancing ADPKD Treatment With GLP-1RA: A Study of Glucagon-Like Peptide-1 Receptor Agonists’ Efficacy, Safety, and Mechanism PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed clinical trial aims to assess if a year of treatment with a glucagon-like peptide 1 receptor agonist, a medication approved for weight management that also improves the body’s response to glucose and insulin, can slow kidney growth in adults with autosomal dominant polycystic kidney disease who are overweight or obese. The study will also evaluate changes in abdominal fat and kidney metabolism using cutting-edge images techniques. Blood and urine samples will provide further insight into biological changes that may be linked to the benefits of the intervention, while ensuring careful monitoring of safety and tolerability. |
KRISTEN NOWAK; | 2025-03-06 |
| 54 | Phase 2b Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Dose-Ranging Study to Assess The Efficacy, Safety, and Tolerability of AZD2373 in Participants With APOL1-Mediated Kidney Disease (APPRECIATE) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the efficacy and safety of AZD2373 in participants diagnosed with APOL1-Mediated Kidney Disease (AMKD) who are homozygotes or compound heterozygotes for APOL1 high-risk genotypes (G1 and G2). The primary hypothesis to be evaluated is that AZD2373, compared with placebo, will result in a greater reduction in UACR as assessed by the relative change from Baseline in UACR at Week 30. |
ASTRAZENECA | 2025-03-05 |
| 55 | A Phase III, Randomised, Double-blind, Placebo-controlled, Event-driven Study to Assess The Efficacy, Safety and Tolerability of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on Renal Outcomes and Cardiovascular Mortality in Participants With Chronic Kidney Disease and High Blood Pressure PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: International, Multicenter, Double-Blind, Placebo-Controlled and Event-driven study to assess efficacy, safety and Tolerability of Baxdrostat in combination with Dapagliflozin on renal outcomes and cardiovascular mortality in participants with chronic kidney disease and high blood pressure |
ASTRAZENECA | 2025-03-03 |
| 56 | Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0: Towards Expanding Our Understanding of Neonatal Acute Kidney Injury PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: There is a growing focus on short- and long-term kidney health in neonates, including those with acute kidney injury (AKI). AKI occurs commonly in the Neonatal Intensive Care Unit (NICU) and is associated with adverse outcomes. In addition to poor outcomes during the hospitalization, infants discharged from the NICU may have an increased burden of kidney disease during childhood. Studies of long-term kidney function in children born prematurely show a fourfold increase in chronic kidney disease (CKD) by adolescence and into adulthood. Despite the landmark findings of the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) study, … |
MICHELLE CASEY STARR; | 2025-03-01 |
| 57 | Guideline-diRected MAnagement for Chronic Kidney Disease: EValuation of An Education Progamme in A National Cluster Randomized Controlled Trial (GRAVER) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Study Objective: To evaluate the impact of guideline-based CKD comprehensive management medical re-education for community healthcare providers on improving cardio-renal outcomes in CKD patients. Study Design: A nationwide, multicenter, prospective, cluster-randomized controlled trial. Inclusion and Exclusion Criteria: Inclusion Criteria: Chronic kidney disease (CKD) patients meeting the following criteria: eGFR \<60 mL/min/1.73 m² or UACR \>30 mg/g on two separate occasions at least 3 months apart. Exclusion Criteria: Age \<18 years. End-stage renal disease (ESRD) with eGFR \<15 mL/min/1.73 m², ... |
JIYAN CHEN; | 2025-03-01 |
| 58 | Impact of A Nephroprotection Bundle-of-care in Severe Trauma Patients at Risk of Acute Kidney Injury: A Multicenter Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute Kidney Injury (AKI) occurs in 24% of trauma patients, and is even more common in those with severe trauma. It is a major contributor to morbidity and mortality in trauma. Diagnosis of AKI is based on elevated serum creatinine and decreased urine output, two functional markers already indicating the presence of a significant kidney function impairment. Earlier detection of kidney stress, at a preclinical stage when cellular modifications are still reversible, … |
CÉLINE MONARD; | 2025-03-01 |
| 59 | The Role of Perirenal Fat As Predictor in Diabetic Nephropathy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1 detect the relationship between perirenal fat thickness (PrFT) and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes (T2DM). 2)Explored the relationship between PRF thickness and the onset and progression of albuminuria in patients with diabetes 3)Evaluate associations between obesity-related markers with albuminuria and advanced kidney disease in patients with type 2 diabetes mellitus (DM) |
MARINA SOBHY GERGES; | 2025-03-01 |
| 60 | Measuring Outcomes in Aortic STenosis Patients Undergoing AVR – Evaluation of Prognosis Regarding Short- and Long-term Results (MASTER) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators will prospectively enroll 300 patients undergoing TAVI at Sahlgrenska University Hospital, which is the second largest TAVI hospital in Sweden. Eligible patients should have a clinical indication for aortic valve replacement with TAVI and have preprocedural clinical investigations with echocardiography (UCG) and CCT and provide written informed consent. UCG, electrocardiogram (ECG) and blood samples will be taken in addition to clinical status, NYHA-class and collection of outcome events the day before the procedure, 1±2 hours, 24 ±6hours and daily after the procedure until discharged from Sahlgrenska. Further follow-up will be scheduled day 14, 30, 180, … |
VASTRA GOTALAND REGION | 2025-03-01 |
| 61 | Safety of Short-term NSAID Use in The Postoperative Setting in Pediatric Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This will be a limited pilot study within a Pediatric Urology population, intended to inform future work in a larger patient population. |
KYLE ROVE; | 2025-03-01 |
| 62 | Two Single Arm, Multicentre Unblinded First-in-human Trials Investigating A Novel Ureteric Stent to Determine The Reduction of Encrustation, Biofilm Deposition and Complications Compared to A Conventional JJ Stent PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Urological stents and catheters often lead to inflammation, causing pain and infection in the urinary tract. Moreover, 80% of stents are associated with pain, negatively impacting on QoL and mental health. Offering novel designs with significantly lower E\&B leads to a reduction in UTIs and improves QoL. Reducing hospital admissions (from 3 to 1 per patient, annually) would free \>100,000 bed-nights, allowing the elderly to regain independence. Our proposed research could have a significant impact towards fulfilling the ‘healthy-ageing’ Grand Challenge. Additionally, the novel stent reduces prevalence of infections and therefore, of antibiotic prescriptions contributing to the Global AMR challenge. |
ALI MOSAYYEBI; | 2025-02-28 |
| 63 | Improving Kidney Therapy Decision-Making for Older People With Advanced Chronic Kidney Disease (CKD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators are conducting a study to see which program better helps older patients with kidney disease choose their treatment. Investigators are also investigating if either program can reduce the number of hospital or emergency room visits in the first 6 months of the study, as well as potentially improve end-of-life care for older adults. Half of the participants will receive Program A, while the other half will receive Program B. Investigators will compare the two groups to see which participants feel better prepared about their kidney therapy decisions, experience improved end-of-life care, … |
FAHAD SAEED; | 2025-02-27 |
| 64 | Effect of Finerenone on Proteinuria and GFR Progression in Patients With Non Diabetic Glomerulonephritis: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to assess the effect of finerenone on proteinuria and GFR progression in patients with non-diabetic glomerulonephritis. |
MOHAMED MAMDOUH MAHMOUD MOHAMED ELSAYED; | 2025-02-20 |
| 65 | Understanding Risk Factors for Progressive Chronic Kidney Disease in Malawi to Inform Interventions for Earlier Detection Ad Prevention (Impso Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The burden of chronic kidney disease (CKD) is rising globally, but disproportionately impacting on low- and middle-income countries (LMIC) including Malawi, which have the fewest resources to manage it. Furthermore, CKD is the leading cause of catastrophic health expenditure worldwide, largely due to the extremely high costs of kidney replacement therapy (KRT) for people with kidney failure. Access to KRT remains limited in many settings, including Malawi, where there is only one nephrologist for a population of over 21 million. It is therefore essential to diagnose and treat CKD in its early stages, … |
HENRY MWANDUMBA; | 2025-02-17 |
| 66 | Study of Therapeutic Efficacy of Anti-CD19 Chimeric Antigen Receptor T Lymphocytes (CAR-T) Cells in Patients with Multi-drug Resistant SRNS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an investigator-initiated trial aimed at assessing the safety and efficacy of anti-CD19 CAR-T cells in the treatment of patients with Multi-drug resistant SRNS |
MAO JIANHUA; | 2025-02-14 |
| 67 | Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease : Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus is a non-transmissible disease whose incidence is growing worldwide . This pathology is defined by a chronic hyperglycaemia linked to a deficiency of either insulin secretion or its action or both. This increased prevalence is linked to the growing of the obese population on one hand, and to the ageing of the population, on the other hand, which is associated with an increased prevalence of metabolic diseases. The number of patients with diabetes, particularly type 2 diabetes (T2D) is regularly increasing. In France, the prevalence of diabetes is 4- … |
PIERRE JEAN SAULNIER; | 2025-02-13 |
| 68 | UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events- A Pragmatic Randomized Controlled Trial in Connect Care PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: Nearly one in ten people who are hospitalized in Canada develop a complication with sudden loss of kidney function, called acute kidney injury (AKI). AKI may lead to other severe health problems after discharge home, such as kidney failure requiring dialysis treatment, heart failure, heart attacks, stroke, and even premature death. Discharge from hospital to home can be a difficult transition where there are often gaps in identification, communication, care coordination, education, … |
NEESH PANNU; | 2025-02-12 |
| 69 | GENomic Predictors in A Multi-Ethnic Population with Kidney Disease Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: To establish a prospective, longitudinal cohort of participants who can provide blood, tissue (including kidney histology), urine samples to establish a core biobank for kidney disease research. Results from this biobank will be matched to clinical outcomes to facilitate the discovery (and/or validation) of novel prognostic, predictive or diagnostic biomarkers important for kidney disease. |
JENNIFER LI; | 2025-02-10 |
| 70 | Clinical Classification and Prediction System of MAFLD Based on Liver Biopsy PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Metabolic dysfunction-associated Fatty Liver Disease (MAFLD), also known as Non-Alcoholic Fatty Liver Disease (NAFLD), is the most common chronic progressive liver disease in China. It is closely related to the high incidence of cardiovascular-renal-metabolic syndrome and both liver and non-liver malignancies, posing a serious threat to public health. However, the diagnostic criteria for MAFLD are not unified globally, and the classification and staging still rely on liver biopsy for pathological assessment. The characteristics, mechanisms, and predictive indicators of liver and extrahepatic disease outcomes in MAFLD patients are not yet clear. The severe form of MAFLD, metabolic dysfunction-associated steatohepatitis (MASH), … |
HONG YOU; | 2025-02-08 |
| 71 | The Real-World Effectiveness of The Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Failure: A Comparative Analysis to Standard of Care Pharmacologic Therapy PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This retrospective, non-randomized cohort study will evaluate how well the Cordella PA Sensor System works compared to standard medication treatment in people with chronic heart failure. The study will track patients for two years to see if those using the Cordella system have fewer deaths and hospitalizations related to heart failure. |
JOANNA VAN HOUTEN; | 2025-02-07 |
| 72 | A Communication-Priming Intervention to Improve Shared Decision-Making Between Older Adults With Advanced Chronic Kidney Disease and Clinicians: A Cluster-Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To achieve the goal of reaching consensus about the preferred treatment option that best aligns with the goals and values of patients, the investigators developed a ‘CKD Jumpstart- Tips priming tool tailored for older adults with advanced CKD that is based on communication principles from VitalTalk and Elwyn’s goal-based SDM model. The investigators hypothesize that compared with patients in the usual care group, patients in the ‘CKD Jumpstart- Tips’ intervention group will have: 1. increased level of shared decision-making (observer-based and patient-reported), 2. improved quality of communication, 3. increased patient involvement in decision-making, 4. lower decisional conflict, … |
YUEN JACQUELINE KWAN YUK; | 2025-02-04 |
| 73 | A Phase 2b, Open-label Study to Evaluate The Efficacy and Safety of Inaxaplin in Subjects With Proteinuric APOL1-mediated Kidney Disease With or Without Comorbidities That May Independently Contribute to Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the efficacy, safety, and tolerability of Inaxaplin (IXP) in participants with proteinuric APOL1- mediated kidney disease (AMKD). |
VERTEX PHARMACEUTICALS | 2025-02-04 |
| 74 | Study of Lipid Profile in Diabetic and Non Diabetic Chronic Kidney Disease Patients in Sohag University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to compare blood lipid (fat) levels in participants with chronic kidney disease (CKD) with diabetes and without diabetes and who over 20 years old. The main question this study aims to answer is: Does having diabetes make fat problems worse in people with chronic kidney disease (CKD), or is there no connection between them? Researchers will compare the blood lipid (fat) levels in people with chronic kidney disease (CKD) who have diabetes and those without diabetes to see if having diabetes makes lipid problems worse in CKD patients, … |
SHAIMAA MAHMOUD ELSAYED ABDEL-RAHEEM; | 2025-02-01 |
| 75 | Belatacept With Delayed Tacrolimus Withdrawal Versus Standard-of-Care Tacrolimus in Heart Transplant Recipients (RTB-013) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase 2, prospective, multi-center, open-label clinical trial. Sixty-six (66) primary heart transplant recipients will be randomized (1:2) to receive either standard-of-care, tacrolimus-based immunosuppression, or a belatacept-based regimen with gradual tacrolimus withdrawal over 9-months post-transplant. Both study arms will receive CellCept® (mycophenolate mofetil- MMF) or Myfortic® (mycophenolate sodium). Corticosteroids will be continued throughout the study in the belatacept arm. The primary objective is to evaluate whether NULOJIX® (belatacept), when implemented with gradual tacrolimus withdrawal over 9 months, … |
MARLENA HABAL; | 2025-01-29 |
| 76 | Addressing Inactive Kidney Transplant Waitlist Status Through Adapting A Tailored Psycho-Social-Environmental Program PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this mixed methods study is to adapt CAPABLE as CAPABLE Transplant to accomplish two things: 1) To resolve barriers to being classified as active on the Kidney Transplant (KT) waitlist and 2) as a surgical prehabilitation intervention targeting the pre-frail/ frail KT waitlist population. It consists of two phases- an open label pilot and a randomized waitlist control trial. |
MELISSA HLADEK; | 2025-01-25 |
| 77 | A Double-blinded, Randomized, Placebo-Controlled Study to Evaluate The Safety, Tolerability, and Preliminary Efficacy of AION-301 Administered By Intravenous Infusion for The Treatment of Participants with Stage 3 Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the safety (good or bad) of giving two AION-301 intravenous (IV) infusions, in adults with Stage 3 Chronic Kidney Disease (CKD). It will also help to learn if AION-301 reduces the symptoms of CKD and/or progression. The main questions it aims to answer are: * Do participants have medical problems (adverse events) after receiving two infusions of AION-301? * Do participants feel better (have reduced and/or delayed CKD symptoms)? * To learn about how AION-301 works in participants with CKD? Researchers will compare AION-301 to a placebo (a look-alike substance that contains no drug) to see if AION-301 works to treat Stage 3 CKD. Participants will: * Receive two infusions of AION-301 or placebo on two separate days (Day 0 and Day 4). * Receive oral vitamins at the clinic and to take at home for 90 days. * Visit the clinic for a minimum of 9 times, over 6 months for checkups and tests, but could be up to 12 times, over 24 months for checkups and tests. |
AION HEALTHSPAN | 2025-01-23 |
| 78 | Prospective Observational Multicenter Study of Patients With Arterial Hypertension and Chronic Kidney Disease Markers in Kazakhstan (PROGRESS-CKD) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Multicenter, non-interventional PRospective Observational study with retrospective analysis to describe the rate of CKD diaGnosis in patients with aRtErial hypErtenSion and CKD markerS in Kazakhstan |
ASTRAZENECA | 2025-01-20 |
| 79 | Intradialytic Versus Interdialytic Resistance Exercises on Quality of Life in Patients with Chronic Kidney Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Fifty chronic kidney disease patients’ ages will range from 40 to 55 years. They will be selected from the dialysis unit. received intra-dialytic combined exercise program for 8 weeks(3 sessions/week), with their medical treatment. |
AMIRA SAAD MOHAMED; | 2025-01-20 |
| 80 | Digital Dyadic Empowerment Program (DDEP) on Lifestyle Modification for Chronic Kidney Disease Management: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to find out if the Digital Dyadic Empowerment Program (DDEP) can help people with chronic kidney disease (CKD) and their care partners make healthy lifestyle changes. The main questions this study will answer are: * Does DDEP help protect kidney function? * Does DDEP support healthier daily habits? Researchers will compare two groups: * One group will receive the DDEP and get usual medical care. * The other group will get usual medical care only. Participants will: * Receive usual care with or without DDEP for six months. * Visit the clinic at the start and end of the study for health checks and tests. * Practice healthy habits at home with or without help from DDEP. This study aims to show if adding DDEP to regular care can make it easier for people with CKD and their care partners to live healthier lives. |
MIAOFEN YEN; | 2025-01-13 |
| 81 | Kidney Function in People With Cystic Fibrosis in The Era of HEMT PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it becomes permanent. The study will compare these markers in people with CF over time and during the treatment of lung flare-ups. It will also compare the blood and urine samples obtained from people without CF. The comparison aims to better understand the impact of cystic fibrosis and its treatment on the kidneys, … |
AGNIESZKA SWIATECKA-URBAN; | 2025-01-09 |
| 82 | Systemic Lupus Erythematosus and Chlordecone Impregnation in Martinique PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chlordecone, an organochlorine pesticide, was widely used on banana farms in the French West Indies. Studies by Inserm and health authorities have confirmed the contamination of the food chain and the majority of the population of the French West Indies by chlordecone. Epidemiological studies conducted in the French West Indies have shown that exposure to chlordecone at the levels observed is associated with an increased risk of developing several diseases, including premature birth and prostate cancer. Many of the adverse effects associated with chlordecone could be explained by its estrogenic hormonal properties, … |
BENOÎT SUZON; | 2025-01-02 |
| 83 | The Association Between Preoperative Hemoglobin and Acute Kidney Injury in Emergency Surgery: A Prospective Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood transfusion or various interventions to increase hemoglobin levels on outcomes continue to be debated. The effects of hemoglobin levels in emergency surgery patients on the development of postoperative AKI have been investigated in a small number of studies in the literature, … |
SAMSUN UNIVERSITY | 2025-01-01 |
| 84 | A Phase I/IIa Randomized, Double-blind, Placebo-controlled Study to Evaluate The Safety and Pharmacokinetics of AZD7760 in Healthy Participants and in Patients With End-stage Kidney Disease Receiving Hemodialysis Through A Central Venous Catheter PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of AZD7760 when given as an intravenous infusion to healthy participants (Phase I) or participants with end-stage kidney disease receiving hemodialysis through a central venous catheter (Phase IIa). |
ASTRAZENECA | 2024-12-30 |
| 85 | A Study to Determine The Prevalence and Clinical Characteristics Associated With PKD1 Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease (ADPKD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to estimate the prevalence, demographic, and clinical characteristics of PKD1/2 gene variant groups in the ADPKD population. |
VERTEX PHARMACEUTICALS | 2024-12-19 |
| 86 | A Phase I, Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study to Assess The Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Established Atherosclerotic Cardiovascular and Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety, tolerability and the pharmacodynamics (PD) of AZD4144 following oral administration in participants with atherosclerotic cardiovascular disease (ASCVD) and chronic kidney disease (CKD). |
ASTRAZENECA | 2024-12-16 |
| 87 | Use of Clinical-trials and Simulation Models to Estimate Cost-effectiveness of Non-steroidal Mineralocorticoid Antagonists, RASi and SGLT2i As Triple Therapy with Type 2 Diabetes and Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate triple therapy with nsMRA, RASi and SGLT2i on albuminuria in individuals with T2D and CKD |
ELAINE CHOW; | 2024-12-12 |
| 88 | A Randomised, Double Blind, Placebo-controlled, Single Ascending Dose, Phase 1a/1b Multi-centre Study in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney Disease to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK4771261 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a study where a new drug, called GSK4771261 is being tested. Neither the study doctors, study staff or participants will be aware of what treatment is being given. Part A is testing the new study treatment on healthy people. This is to see if it’s safe, what it does to the body, and how the body’s defense system responds to it. Part B is similar, but the study treatment will be given to people who have a kidney disease called autosomal dominant polycystic kidney disease (ADPKD). |
MICHALIS S KOSTAPANOS; | 2024-12-11 |
| 89 | Oxalate Excretion Profile in Patients with A Heterozygous Mutation of The AGXT (alanine-glyoxylate Aminotransferase) Gene – Influence of Hygienic and Dietary Conditions and Identification of Favouring Factors By Comparison of Asymptomatic and Symptomatic Patients (lithiasis or Oxalic Nephropathy) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary hyperoxaluria type I (PH1) is a rare genetic disorder responsible for severe lithiasis leading to progressive deterioration of renal function and end-stage renal failure. PH1 is linked to a deficiency in glyoxylate amino transferase (AGXT), which leads to increased endogenous oxalate synthesis and hyperoxaluria. In the urine, urinary oxalate precipitates with calcium, forming insoluble crystals, leading to lithiasis and the development of nephrocalcinosis. Non-genetic etiologies of oxalic nephropathy are well known, in particular enteric causes (malabsorptions, bypass, calcium deficiencies, etc.) and sometimes linked to increased oxalate intake in the form of nutritional or vitamin supplements, … |
HOSPICES CIVILS DE LYON | 2024-12-11 |
| 90 | An Open-Label, Single-Dose, Phase 1 Study to Evaluate The Pharmacokinetics and Safety of BMS-986278 in Participants With Normal Renal Function, Participants With Severe Renal Impairment, and Participants With End-Stage Renal Disease on Intermittent Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the effect of severe renal impairment (RI) and end-stage renal disease (ESRD) with intermittent hemodialysis (IHD) on the pharmacokinetics and safety of BMS-986278. This study plans to use a staged design based on RI severity. |
BRISTOL MYERS SQUIBB | 2024-12-07 |
| 91 | A Multinational, Observational, Retrospective, Secondary Data Study Describing Management and Treatment in Routine Clinical Practice Among Patients With Chronic Kidney Disease. Local Adaptation for Spain. Part 1 PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: OPTIMISE-CKD is a retrospective, observational study, using secondary data. The incidence of renal disease, including CKD, using eGFR or UACR laboratory measurements and diagnostic codes will be assessed in the study population. The study will also assess the incidence of selected cardiovascular and renal events and the current use of kidney-protective treatments. |
ASTRAZENECA | 2024-12-04 |
| 92 | Evaluation of Venous Congestion Using Doppler and Venous Excess Ultrasound Score (VExUS) During Acute Respiratory Distress Syndrome and Its Association with Acute Kidney Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A single-center prospective observational study will be conducted with the aim of determining the prevalence of venous congestion during ARDS using venous Doppler and the VExUS score. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2024-12-02 |
| 93 | Efficacy, Safety and Pharmacokinetics of NNC0519-0130 Once Weekly S.c. Versussemaglutide 1.0 Mg and Placebo in People With Chronic Kidney Disease, With or Without Type 2 Diabetes, and With Overweight or Obesity: A Proof-of-concept and Dose-finding Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study evaluates the safety of different doses of a new medicine called NNC0519 0130. It also looks into how the medicine may improve kidney function in participants with chronic kidney disease with or without type 2 diabetes, living with overweight or obesity. The participants will either get NNC0519-0130 (a new medicine), semaglutide (a medicine that doctors can already prescribe), or placebo (a dummy substance). Which treatment the participant will get is decided by chance. The study will last for up to 43 weeks. |
NOVO NORDISK | 2024-12-02 |
| 94 | Evaluation of Clinical Impact of The Type of Cardioplegia Used in The Patient Undergoing Major Cardiac Surgery with Extracorporeal Circulation. CARDIO-HEART Clinical Trial PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase IV clinical trial of a single-blind, prospective and longitudinal randomized intervention comparing patients undergoing major cardiac surgery with extracorporeal circulation who are administered Custodiol crystalloid cardioplegia versus Buckberg blood cardioplegia. |
LOURDES MONTERO CRUCES; | 2024-12-01 |
| 95 | Clinical Study Evaluating The Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy (LSG) for Morbid Obese Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Assessment of the effect of gabapentin as an analgesic replacement on the Kidney function following Laparoscopic sleeve gastrectomy for Morbid Obese Patients by measuring two biomarkers: NGAL (Neutrophil gelatinase-associated lipocalin)and DKK3 (Dickkopf-3) |
KHOLOUD SALAH IBRAHIM AMIN; | 2024-12-01 |
| 96 | Comparison The Effectiveness of Stroke Volume Variation Versus Central Venous Pressure Guidance for Reducing Perioperative Blood Loss During Open Liver Resection: A Prospective, Double-Blinded, Noninferiority, Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Liver resection is a major surgery that can be associated with significant intraoperative blood loss and blood transfusion. Among high-volume centers, median intraoperative blood loss ranges between 300-800 ml. Excessive blood loss is a strong independent predictor of worsened postoperative outcomes, increasing morbidity and mortality rates by 20%-35%. Additionally, perioperative allogeneic blood transfusions are associated with deleterious outcomes, including tumor recurrence and increased rates of complications and death. The liver is a highly vascular organ with minimal vascular resistance, … |
WARANGKANA LAPISATEPUN; | 2024-11-25 |
| 97 | A Multicenter, Randomized,Positive Controlled, and Placebo-controlled Phase II Clinical Study Evaluating The Efficacy and Safety of MT1013 Injection in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Undergoing Maintenance Hemodialysis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, positive controlled, and placebo-controlled phase II clinical study to evaluate the efficacy and safety of MT1013 injection in the treatment of chronic kidney disease with secondary hyperparathyroidism (SHPT) undergoing maintenance hemodialysis (MHD) subjects. |
SHAANXI MICOT TECHNOLOGY LIMITED COMPANY | 2024-11-18 |
| 98 | A Single Dose, Non-randomised, Open-label, Parallel Group Study to Assess The Pharmacokinetics, Safety, and Tolerability of AZD4144 in Participants With Severe Renal Impairment, End-stage Kidney Disease, and in Healthy Participants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A study to investigate the pharmacokinetics, safety, and tolerability of AZD4144 in participants with severe renal impairment, end-stage kidney disease, and in healthy participants |
ASTRAZENECA | 2024-11-18 |
| 99 | Impact of Probiotic Supplementation on Urinary Tract Infections and Clinically Relevant Outcomes of Kidney Transplant Recipients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to assess if dietary supplememtation with OMNi-BiOTiC® 41167 reduces the risk of urinary tract infections in kidney transplant recipients. It will also assess whether it reduces the risk of graft rejection, modify immunosuppressive regimen, improves post-transplant gastrointestinal and bladder microbiome, … |
UMBERTO BACCARANI; | 2024-11-15 |
| 100 | Inflammation REduction to Prevent CArdiovascular Injury in Renal Disease (REPAIR) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Phase 1 basket trial including 2 open-label single-arm cohorts: REPAIR CKD cohort and REPAIR Dialysis cohort. Open label colchicine 0.3 mg daily for 8 weeks followed, in patients who tolerated the 0.3 mg dose, by forced titration to 0.6 mg daily for 8 weeks. |
MICHAEL WALSH; | 2024-11-15 |
| 101 | A Dose Escalation Study of IG3018 to Evaluate The Safety, Tolerability, Efficacy and Pharmacokinetics in Subjects With Hyperuricemia With or Without Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase I/II clinical study to evaluate the safety, tolerability, PK, and efficacy of IG3018 tablet in hyperuricemia (HUA) subjects with or without CKD. |
INTELLIGEM THERAPEUTICS AUSTRALIA PTY | 2024-11-12 |
| 102 | Association Between Elevated Liver Functions Tests Following Cardiac Surgery and Acute Kidney Injury – A Restrospectiv Single Center Cohort Study PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: A sudden decline in function of the kidneys is a common problem that can happen after heart surgery. It can have serious effects on a patient’s recovery and long-term health, potentially leading to permanent kidney problems or heart-related issues. One of the main reasons kidney problems occurs is due to changes in blood flow caused by the heart not pumping well enough. These changes may harm the kidneys, … |
WIM VANDENBERGHE; | 2024-11-06 |
| 103 | A Randomized, Double-blind, Placebo-controlled Multiple-ascending Dose Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AP303 Following 2-week Oral Administration in Diabetic Kidney Disease Patients with Renal Impairment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will be a single center, double-blind, randomized, placebo-controlled, multiple-ascending-dose study to evaluate the safety, tolerability, PK and PD of AP303 following 2-week oral administration to Diabetic Kidney Disease patients. |
HONG ZHANG; | 2024-11-05 |
| 104 | Spatial RadiomIcs and TRanscriptomics to The DIscovery of The Cross-link Between Colon Cancer and ChrOnic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The incidence of colorectal cancer (CRC) is higher in patients with chronic kidney disease (CKD) compared to general population. Causal factors have not been clarified so far, although some hypothesis could be formulated. Tumor microenvironment (TME) impacts cancer progression and is influenced by different chronic diseases associated with systemic inflammation. In our study, we aim to address this relevant issue by an in-deep characterization of TME in CKD patients with CRC undergoing surgery. This will provide genes expression directly on tumor tissues. Our network includes three high national relevance hospitals (INT IRCCS Pascale, … |
ANTONELLA PETRILLO; | 2024-11-05 |
| 105 | Investigation of Knowledge of Cardiovascular Risk Factors and Perception of Benefits and Barriers to Exercise in Patients with Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to assess knowledge of cardiovascular risk factors, physical activity levels, health literacy and perceptions of benefits and barriers to exercise in patients with chronic kidney disease and compare them with healthy people. |
MERVE FIRAT; | 2024-11-01 |
| 106 | Effectiveness and Safety of Sotagliflozin in Slowing Kidney Function Decline in Persons With Type 1 Diabetes and Moderate to Severe Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Powerful new drugs that can prevent or delay end stage kidney disease (ESKD) – so called sodium-glucose cotransporter-2 inhibitors (SGLT2i) – are now available for patients with type 2 diabetes. Whether these drugs have similar effects in patients with type 1 diabetes (T1D) remains unknown because of the few studies in this population, due to concerns about the increase in risk of diabetic ketoacidosis (DKA, a serious, … |
ALESSANDRO DORIA; | 2024-10-31 |
| 107 | Emulation of The Effects of Oral Semaglutide on Cardiovascular Outcomes in Individuals With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease And/or Chronic Kidney Disease: SOUL Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials. The investigators’ goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies. |
SHIRLEY VICHY WANG; | 2024-10-24 |
| 108 | In-Hospital Morbidity Associated with Proton Pump Inhibitors in Acute Variceal Bleeding and Chronic Liver Disease Treatment PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: With this study, the investigators pretend to describe intrahospital morbidity in patients living with cirrhosis (PLC) who present to the emergency department with variceal bleeding (VB). This study is a longitudinal, prospective, experimental, analytical single-center clinical trial. The study will be performed in the Hospital Universitario Jose E. González de la Factultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México. The studied population consists of adult-age patients with previous, recent, or new diagnoses of cirrhosis who present to the ED with VH without shock, infection, … |
LUIS ANDRÉS GONZÁLEZ TORRES; | 2024-10-20 |
| 109 | Beneficial Effect of Amiloride on Progression of Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, placebo-controlled, double-blinded crossover trial testing the effects of amiloride in patients with chronic kidney disease (CKD) and proteinuria. In CKD with proteinuria, there is aberrant filtration of serine proteases and complement precursors into the tubular lumen. The interaction of these factors leads to proinflammatory complement activation, which may promote inflammation, opsonization, and formation of the membrane-attack complex, causing cell injury. With the aim of preserving kidney function, reducing cardiovascular morbidity, and delaying renal replacement therapy in CKD, this study tests whether amiloride (10 mg/day) protects the filtration barrier, lowers albuminuria, … |
ODENSE UNIVERSITY HOSPITAL | 2024-10-10 |
| 110 | Effects of The ABCA1 Inducer R3R01 on Albuminuria Levels in Diabetic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to to investigate whether the drug R3R01 has a beneficial effect on the amount of protein excreted in the urine in adult patients (above 18 years of age) with type 2 diabetes and resulting kidney disease. The main questions it aims to answer are: 1. Does 3 months of treatment with 200mg of the drug R3R01 morning and evening have a beneficial effect on the amount of protein excreted in the urine in patients with type 2 diabetes and kidney disease? 2. Does R3R01 have an effect on kidney function and daily blood pressure? Researchers will compare the results of 40 people who take R3R01 to 20 people who receive an inactive substance (placebo). Participants will receive R3R01 or the placebo as an oral tablet and undergo a selection of medical examinations – such as: * blood samples * urine tests * kidney tests involving a radiolabelled marker which is injected into the bloodstream and monitored via blood samples * 24 hour blood pressure monitoring via a wearable device * urine pregnancy test (if applicable) |
PETER ROSSING; | 2024-10-10 |
| 111 | Diagnostic and PROgnostic BIOmarkers Before and After Kidney Transplantation PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: In clinical nephrology, the search for urinary, blood and tissue biomarkers of specific kidney diseases is an important goal. In recent years, the use of these biomarkers has made it possible to diagnose many renal diseases that affect the native kidney. In some cases, biomarkers may be useful in determining the evolutionary profile of the disease and thus the most appropriate therapeutic management. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2024-10-08 |
| 112 | The Impact of Resistance Exercise on Symptom Burden in Older Patients Undergoing Maintenance Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if an intradialytic resistance exercise intervention works to reduce the symptom burden in older maintenance hemodialysis patients. It will also learn about safety of the intradialytic resistance exercise intervention program. The main questions it aims to answer are: 1. Does intradialytic resistance exercise effectively improve the number, frequency, … |
TENG ZENG; | 2024-10-03 |
| 113 | Comparison of Silodosin Versus Tamsulosin on Passage of Acutely Obstructing Ureteral Calculi (History of Last 4 Weeks) in Medical Expulsive Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: As a first treatment option for small-size ureteric stones, α-blockers are now being used for medical expulsive therapy (MET) instead of invasive procedures. There is high evidence of the therapeutic benefit of α-blockers in the treatment of Distal ureteric stone (DUS); also endorsed by international guidelines. However, limited data is available worldwide, on the effect of silodosin to treat DUS. A multi-center study is needed to confirm the efficacy and safety of therapy. |
SALMAN EL KHALID; | 2024-10-01 |
| 114 | Association of Green Propolis Extract and Royal Jelly to Modulate Inflammation and Oxidative Stress in Hypertensive Patients And/or With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension (SAH), in a longitudinal, randomized, double-blind, placebo-controlled clinical trial that will be carried out for 2 months. |
DENISE MAFRA; | 2024-10-01 |
| 115 | Effects of An Exercise Program and A Protein Controlled Diet Using An Educational Intervention on Biochemical Parameters, Muscle Strength and Body Composition in Patients With Stage G1 and G2 CKD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: How Exercise, a Controlled Diet and Education Improve the Health of People with Early-Stage Renal Failure: A Study at Ciudad Guzmán Hospital |
ANA PATRICIA ZEPEDA SALVADOR; | 2024-10-01 |
| 116 | Multi-Component Behavioral Activation, Nutrition, and Activity Intervention for Persons Aging With HIV PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will explore if a behavioral intervention program to assist people aged 50 and older with HIV is practical. The program includes a coach who talks with participants, encouraging them to be more active, reduce loneliness, and eat healthier. |
ANN GRUBER-BALDINI; | 2024-09-23 |
| 117 | Evaluate The Role of Soleus Muscle Exercise in Glycaemic Control in Diabetic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the role of Soleus muscle exercise in management diabetic kidney disease |
NORA HUSSEIN KAMAL; | 2024-09-18 |
| 118 | Effects of Exogenous Ketosis on Proteinuria and Renal Function in Patients with Chronic Kidney Disease and Patients with Polycystic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized, placebo-controlled, double-blinded crossover study will be conducted. Fourteen patients with polycystic kidney disease (PKD) and 29 patients with proteinuric kidney disease will receive ketone bodies (Ketone-IQ) and placebo in a randomized order. Each treatment period is four weeks. There will be a wash-out period of two weeks in between treatment periods. Effect variables will be measured in the last day of each treatment period. |
TRINE Z LYKSHOLM; | 2024-09-11 |
| 119 | Retrograde Intrarenal Surgery Versus Mini-Percutaneous Nephrolithotomy for Treatment of Medium Size Pediatric Renal Stones (10-20millimeters). A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare RIRS versus mini-perc PNL in the management of medium size pediatric renal stones (10-20 mm) through a RCT. |
RAMY ELBAZ; | 2024-09-10 |
| 120 | The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD). CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the progression of CKD so that fewer people develop kidney failure. CAPTIVATE provides a research platform that allows many treatment-related questions to be answered within a common trial set-up. |
THE GEORGE INSTITUTE | 2024-09-04 |
| 121 | Detection of Plasma DNA of Renal Origin in Kidney Transplant Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Donor-derived cell-free DNA (dd-cfDNA) has been proposed as a potential diagnostic tool to monitor the rejection status of the kidney transplant. It has been suggested that dd-cfDNA is increasing in the blood of kidney transplant patient presenting a graft rejection. In this project, investigators proposed a different approach to predict and characterize kidney transplant rejection/dysfunction based on the quantification of epigenetic signatures present on the donor-cell-free DNA. In 2018, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2024-09-02 |
| 122 | The Effect of Probiotics Versus Activated Charcoal in The Management of Chronic Kidney Disease Patients Suffering From Uremic Pruritus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to evaluate the efficacy and safety of probiotics versus activated charcoal in management of chronic kidney disease patients suffering from uremic pruritus. Patient data collection Demographic data:The following data will be collected from the patient records; including age, sex, weight, height. History Taking :Including patient’s medical history, past surgical history, family medical history, and medications the patient is taking or may have recently stopped taking. A patient’s medical history may also include information about allergies, … |
ALIAA MOHAMED ASHRAF MOHAMED HAGR; | 2024-09-01 |
| 123 | Frequncy and Risk Factors of Bleeding in Patients With Chronic Kidney Disease Receiving Antigoagulants PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 1-Introduction: Chronic kidney disease (CKD) is a significant global public health issue, closely linked to cardiovascular disease (CVD). Moreover, CKD is acknowledged as an independent risk factor for developing CVD and represents a heigh risk factor to thromboembolic disease in coronary and cerebral arteries also in the venous circulation that requires anticoagulation (1). According to the latest United States Renal Data System report, the prevalence of any CVD in CKD patients is nearly double that of the general population, at 69.8% compared to 34.8% (2). Also, if microalbuminuria is detected and glomerular filtration rate (eGFR) is less than <60 mL/min/1.73m2, ... |
MOHAMED MAHMOUD ABOZAID; | 2024-09-01 |
| 124 | Short-term Effects of An SGLT2 Inhibitor on Divalent Ions in Autosomal Dominant Polycystic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to better understand electrolyte handling in patients with autosomal dominant polycystic kidney disease treated with the SGLT2 inhibitor Empagliflozin. Patients will be randomized into two groups and take Empagliflozin or a Placebo for 2 weeks with a wash-out period of 2 weeks. The primary outcome is tubular handling of the divalent ions calcium, phosphate and magnesium. Secondary outcomes include diuresis, safety and tolerability. |
PATRICK HOFMANN; | 2024-09-01 |
| 125 | A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Povetacicept in Adults With Immunoglobulin A Nephropathy (RAINIER) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of povetacicept in adult participants compared with placebo in reducing proteinuria and preserving renal function. |
ALPINE IMMUNE SCIENCES INC A SUBSIDIARY OF VERTEX | 2024-08-30 |
| 126 | Anesthetic Management in Patients Undergoing Epicardial Ablation for The Treatment of Ventricular Tachycardia; Retrospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is a retrospective study and is descriptive in nature. In this study, the investigators aimed to emphasize the importance of anesthesia management by cardiac risk assessment of patients undergoing epicardial ablation under general anesthesia and analysis of complications that developed during the procedure. |
FERDA YAMAN; | 2024-08-30 |
| 127 | An Interventional, Multicentre, Phase IV, Single-Arm, Open-Label Study to Investigate The Efficacy and Safety of Dapagliflozin in Chinese Adult Patients With Chronic Kidney Disease PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to describe the efficacy and safety information with dapagliflozin in Chinese patients with chronic kidney disease. |
ASTRAZENECA | 2024-08-23 |
| 128 | Feasibility Trial of Sodium-GLucose CoTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn if a clinical trial of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is possible in youth with chronic kidney disease (CKD). The investigators also plan to explore whether treatment with SGLT2i (Empagliflozin) helps improve risk factors for worsening kidney and heart disease. The main questions are: 1. Is enrolling 40 youth with CKD into a clinical trial of empagliflozin feasible (ie achievable)? 2. Does taking empagliflozin for 3 months result in positive changes in blood, urine, … |
ALEXANDER KULA; | 2024-08-23 |
| 129 | Comparative Efficacy of Amlodipine Folic Acid Vs. Amlodipine on The Risk of First Ischemic Stroke Among Participants with Hypertension and MTHFR 677 TT Genotype: A Multi-center, Randomized, Double-blind, Triple-dummy, Controlled Clinical Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, double-blind, triple-dummy, controlled trial in 24,000 Chinese men and women with hypertension and MTHFR 677 TT genotype. The study participants will be randomized to one of the three treatment groups: Group A: amlodipine tablet (5mg), taken orally, once daily, serving as active comparator. Group B: amlodipine folic acid 5.8mg tablet (5mg amlodipine and 0.8mg folic acid), taken orally, once daily. Group C: amlodipine folic acid 5.8mg tablet plus 5-methyltetrahydrofolate (5-MTHF, 0.4mg), taken orally, once daily. The primary endpoint is first ischemic stroke. |
JIANPING LI; | 2024-08-22 |
| 130 | Comparative Efficacy of Amlodipine Folic Acid Vs. Amlodipine on The Risk of First Ischemic Stroke Among Participants with H-type Hypertension and MTHFR 677 CC/CT Genotype: A Multi-center, Randomized, Double-blind, Double-dummy, Controlled Clinical Trial PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multi-center, randomized, double-blind, double-dummy, controlled clinical trial. This trial will include 32,000 Chinese men and women with hypertension (H-type hypertension), MTHFR 677 CC or CT genotype, elevated plasma total homocysteine (tHcy ≥10µmol/L), and insufficient serum folate levels (\<12ng/mL). The participants will be first stratified by their MTHFR 677 genotype (CC vs. CT), then randomized to one of two treatment groups in a 1:1 ratio. Group A: amlodipine tablet (5mg), taken orally, once daily, serving as active comparator. Group B: amlodipine folic acid 5.8mg tablet (5mg amlodipine and 0.8mg folic acid), taken orally, ... |
YONG HUO; | 2024-08-22 |
| 131 | The Effect of Reiki Therapy on Pain Severity and Quality of Life in Patients Undergoing Hemodialysis: A Follow-Up and Evaluation Study of First-Level Reiki Versus Second-Level Reiki Application PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Purpose: The aim of this study is to determine the effect of 20-minute second-level Reiki application for 4 consecutive days on pain intensity and quality of life in patients receiving hemodialysis (HD) treatment and It is a comparison of the follow-up results of the first level Reiki applied within the scope of the doctoral thesis and the second level Reiki applications to be applied within the scope of this study. Method: The study will be conducted as a pre-test-post-test, double-blind, randomized controlled trial. After obtaining Ethical Committee approval, … |
SULTAN ÇEÇEN; | 2024-08-19 |
| 132 | A Multicenter, International, Randomized, Double-blind, Placebo-controlled Clinical Trial of The Aldosterone Synthase Inhibitor BI 690517 in Combination With Empagliflozin in Patients With Chronic Kidney Disease PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart disease. This study has 2 parts. In the first part, participants get empagliflozin or placebo matching BI 690517 for at least 6 weeks. Participants continue taking ACEi or ARB throughout the study if such treatments are indicated. In the second part, participants are divided into 2 groups by chance. One group takes BI 690517 tablets and the other group takes placebo tablets. Placebo tablets look like BI 690517 tablets but do not contain any medicine. Participants take 1 tablet once a day in addition to empagliflozin for the duration of the study. The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 4 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants’ health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects. |
BOEHRINGER INGELHEIM | 2024-08-13 |
| 133 | Effects Of Sleep Hygıene Educatıon And Motıvatıonal Intervıewıng On Sleep Hygıene, Sleep Qualıty And Qualıty Of Lıfe In Hemodıalysıs Patıents: A Randomızed Controlled Trıal PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: – Sleep hygiene education and motivational interviewing have an effect on increasing sleep hygiene in individuals undergoing hemodialysis treatment – Sleep hygiene education and motivational interviewing have an effect on increasing sleep quality in individuals undergoing hemodialysis treatment – Sleep hygiene education and motivational interviewing have an effect on increasing quality of life in individuals undergoing hemodialysis treatment |
MELEK AVCI; | 2024-08-10 |
| 134 | Safety, Efficacy and Tolerability of Bowel Preparation and Colonoscopy in Patient With Chronic Heart Disease, Chronic Kidney Disease and Chronic Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Consecutive eligible patients will be enrolled and written informed consent will be obtained from all participants. Routine blood investigations will be sent. Patients with chronic heart failure will be classified based on ejection fraction into 2 groups (EF \ 40%), patients with chronic kidney disease will be classified based on KDIGO classification system into grade I-V. Patients with chronic liver disease will be classified according to the child pugh scoring system into three groups (Child A, B and C). All patients will be undergo bowel preparation under supervision. The patients will be given 10 mg of bisacodyl, … |
MOHAN RAMCHANDANI; | 2024-08-10 |
| 135 | A Phase 2b Dose-finding, Randomized, Placebo-controlled, Double-blind Study to Evaluate Efficacy and Safety of BAY 3283142 on Top of Standard of Care in Reducing Albuminuria in Patients With Chronic Kidney Disease PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Researchers are looking for a better way to treat people who have chronic kidney disease (CKD), CKD is a condition in which the kidneys’ ability to work properly gradually decreases over time. A common sign of decreasing kidney function is the body losing too much of a protein called albumin in the urine. This condition is known as albuminuria. This can lead to a faster decline in kidney function. People who have high blood pressure and diabetes are more likely to have CKD and are at a higher risk of complications related to it. BAY3283142 is a new drug that is being developed to treat people with CKD. It works by activating a protein that helps relax blood vessels and is thought to have beneficial effects in CKD. In this study, researchers want to learn about how well different doses of BAY3283142 work when taken with standard treatment for CKD in reducing albumin in the urine of participants with CKD. They will compare the results of the change in the urine albumin-creatinine ratio (UACR) after 16 weeks for BAY3283142 with a placebo. A placebo looks like the study drug but does not have any medicine in it. During the study, participants will take either of the following drugs: * BAY3283142: Participants will take BAY3283142 as tablets by mouth. * Placebo: Participants will take it in the same way as BAY3283142. Participants will continue taking the available standard treatment for CKD and other conditions they may have (for example, heart conditions and diabetes). At the start of this study, the researchers will check the medical history and current medications of the participants. They will also perform a complete health check-up of all the participants. Researchers will take urine and blood samples from the participants at different time points to measure UACR and eGFR. Participants will be divided equally into different groups. Only 1 group will receive placebo and the other groups will receive BAY3283142. Participants will take their assigned treatment for 16 weeks. No one will know who receives which drug or dose of BAY3283142 during the study. Participants will be in this study for around 23 weeks. This includes the time for screening before the start of treatment and follow-up with participants after treatment. People can join this study if they: * are 18 years of age or older and have been diagnosed with CKD * have poor kidney function according to the eGFR test * have abnormally high levels of albumin in the urine according to the UACR test * have been taking certain drugs at a stable dose for management of high blood pressure, diabetes, kidney disease, etc. for at least 4 weeks before the start of the study People cannot join this study if they: * have low blood pressure * have had a stroke or a heart attack, or were hospitalized because of heart failure in the 3 months before the start of the study * have a serious liver disease * have a kidney disease for which they need to take drugs that control the immune system The detailed requirements will be discussed between the study doctors and people considering joining this study. Participants may or may not get the expected benefits of treatment with BAY3283142, but they will receive thorough medical check-ups during this study. These can help to improve individual treatment in the future and to identify unknown medical risks. Some participants may experience medical problems during this study including pain and discomfort when blood samples are taken. Researchers will closely monitor and manage any medical problems the participants may have. They will not include people who should not take BAY3283142 due to known safety concerns. The findings from this study may contribute to developing a new treatment option for people with CKD who have excess albumin in the urine. |
BAYER | 2024-08-08 |
| 136 | Contrast-free IVUS Guided PCI Compared to Standard Angio-guided PCI in Patient With SEvere KidnEy Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The incidence of contrast-induced nephropathy (CIN) is high (\> 25%) in patients with severe chronic renal disease (CKD) who undergo a percutaneous coronary procedure. The development of CIN is a factor of poor prognosis and is associated with the occurrence of irreversible CKD, the need for dialysis, increased length of stay and hospital costs as well as the risk of death. There is no specific treatment for N-PCI, so its prevention is essential. Although many studies have been conducted to identify, compare and implement different pharmacological strategies for the prevention of CIN before percutaneous coronary procedurse, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2024-08-08 |
| 137 | Effects of Whole-body Electrostimulation on Kidney Function and Physical Capacity of Patients With Chronic Kidney Disease: Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) consists of kidney damage, with consequent progressive and irreversible loss of kidney function. In the early stages of the disease, a reduction in circulating levels of the α-klotho protein is already observed, which is related to worsening renal function. Therapeutic strategies that increase serum levels of α-klotho may be of great value in the treatment of CKD. Electrical stimulation contributes to the reduction of reactive oxygen species, DNA damage and improves the effectiveness rate of dialysis, … |
JOCIANE SCHARDONG; | 2024-08-01 |
| 138 | Glucagon-like Peptide-1’s Effect on Renal Regional Blood Flow and The Renal Function in Patients With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this double-blinded, placebo-controlled, randomized, crossover study is to examine the effect of semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), on renal hemodynamics and function in patients with type 2 diabetes mellitus (T2DM) and moderate chronic kidney disease (CKD). The study will determine the effects of semaglutide on: – Renal arterial blood flow, regional renal perfusion, and oxygenation – Activity of the renin-angiotensin-aldosterone system (RAAS) – The glomerular filtration rate (GFR) – Sodium excretion in urine – Blood pressure and heart rate |
ALI ASMAR; | 2024-08-01 |
| 139 | Effects of Royal Jelly Supplementation on Inflammation and Cellular Senescence in Chronic Kidney Disease Patients Under Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to evaluate the effects of royal jelly on inflammation and cellular senescence in patients with chronic kidney disease (CKD) on hemodialysis (HD). |
UNIVERSIDADE FEDERAL FLUMINENSE | 2024-07-30 |
| 140 | Metabolomics Analysis of Acute Kidney Injury and Delirium After Cardiac Surgery: Single Center, Prospective, Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinical evidence suggests that renal injury leads to changes in the structure of the cerebral cortex in patients, suggesting the existence of the renal brain axis. Therefore, some scholars have proposed that AKI may be an important cause of secondary injuries such as delirium. Approximately 60% of AKI patients in clinical practice experience delirium.Although the underlying mechanism associated with acute renal injury and delirium is still unclear, it has been recognized that it increases incidence rate and mortality, prolongs hospital stay, … |
CHONG LEI; | 2024-07-20 |
| 141 | A Phase 1, Open-label, Single-dose Study to Evaluate The Pharmacokinetics, Safety, and Tolerability of Avacopan in Subjects With Normal Renal Function and Subjects With End-Stage Renal Disease (ESRD) Requiring Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of the study is to evaluate the pharmacokinetics (PK) of avacopan and metabolite (M1) after a single dose of avacopan in participants with normal renal function and participants with ESRD requiring hemodialysis (HD). |
AMGEN | 2024-07-11 |
| 142 | REFORM-HF™ Reducing Fluid Overload Using Renal Independent SysteM in Heart Failure Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The REFORM-HF study aims to test a new technology, AquaPass, designed to assist patients experiencing symptoms of fluid overload due to Heart Failure. Patients will wear a lightweight suit that helps remove excess fluids through their sweat. We want to see if AquaPass can remove an additional 500mL of fluids during treatment, alongside patients’ regular medications like diuretics. Participants will select if to be treated at their home or in the outpatient clinic. |
AQUAPASS MEDICAL | 2024-07-03 |
| 143 | Investigation of Other Predictive Features of The ACTA PORT Score Used in Predicting Intraoperative Blood Transfusion in Open-heart Surgery Patients PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: In the scope of this study, it will be determined whether the ACTA-PORT (Association of Cardiothoracic Anesthetists perioperative risk of blood transfusion) scoring system can predict the incidence of events in other organ systems, and the feasibility of conducting multiple assessments using a single simple score will be investigated. |
CANSUHAN AKAR YİĞİT; | 2024-07-01 |
| 144 | Outcome and Improvement of Different Treatment in Arteriosclerosis Obliterans: A Prospective, Single-center, Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a prospective, single-center, observational study. In this study, we aim to evaluate the clinical outcome and cost-effectiveness of different treatments of lower extremity arterial occlusive disease. It is expected to include about 400 patients diagnosed with lower extremity arterial occlusive disease in our center from July 2024 to July 2026. All enrolled patients will be followed for three years. All patients diagnosed with arteriosclerosis obliterans (ASO) and all treatment techniques were included in this study. The primary outcomes include the Efficacy and Safety End Points of each techniques. |
ZILUN LI; | 2024-07-01 |
| 145 | Auxora for The Treatment of AKI and Modulation of Injurious Crosstalk With The Lung: A Randomized Control Trial (KOURAGE) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Approximately 150 patients with acute kidney injury (AKI) associated with acute hypoxemic respiratory failure (AHRF) will be randomized at up to 40 sites. Patients will be randomly assigned to either Auxora or matching placebo. Study drug infusions will occur every 24 hours for five consecutive days for a total of five infusions. |
JAVIER NEYRA; | 2024-07-01 |
| 146 | Diabetic Foot Amputations: A Comprehensive Review of Anesthetic Procedures and Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetic Foot Amputations: A Comprehensive Review of Anesthetic Procedures and Outcomes Introduction: Diabetic foot is a severe complication of diabetes, often resulting in ulceration, osteomyelitis, and gangrene. Amputation or surgical debridement is the standard treatment for advanced cases. The study aims to evaluate the outcomes of different anesthetic techniques in diabetic foot amputation, specifically comparing peripheral nerve block (PNB) and general anesthesia. Objective: To assess the impact of anesthetic procedures on outcomes in diabetic foot amputation cases using inpatient data. The hypothesis is that PNB will result in fewer postoperative complications than general anesthesia-primary outcome: 30-day mortality; … |
SEMIH BAŞKAN; | 2024-07-01 |
| 147 | EFFECT of ZINC SUPPLEMENTATION on HYPERHOMOCYSTEINEMIA COMPARED to THAT of FOLIC ACID in PATIENTS of CHRONIC KIDNEY DISEASE on HEMODIALYSIS-A RANDOMIZED CONTROLLED TRIAL PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Hyperhomocysteinemia is a well-recognized risk factor for accelerated cardiovascular events in hemodialysis patients. Hyperhomocysteinemia is common in individuals with chronic kidney disease (CKD). Zinc is a vital cofactor for homocysteine metabolism enzymes. Although numerous studies have demonstrated the efficacy of folic acid in hyperhomocysteinemia, … |
ZAKWAN ULLAH; | 2024-07-01 |
| 148 | Efficacy of On-venous Laser Irradiation of Blood on Diabetes Kidney Disease Patients: A Single Center, Randomized, Assessor- and Participant-blind, Controlled, Cross-over Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The single center, randomized, assessor- and participant-blind, controlled, cross-over on-venous laser irradiation of blood clinical trial was performed to analyze patients with DKD. The information will help to whether integration of laser acupuncture into patient care will help to improve the clinical symptoms and quality of life. |
YU-CHEN LEE; | 2024-07-01 |
| 149 | Effect of A Concurrent Physical Exercise Program on Quality of Life in Hemodialysis Patients: Uncontrolled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Concurrent physical exercise is the method of combining strength and endurance that can be worked with in one session or in an exercise program. Therefore, the researchers seek to implement it in patients suffering from chronic renal failure with hemodialysis therapy and see if concurrent physical exercise improves quality of life levels and at the same time see the response of physical fitness, body composition and biochemistry. |
PEDRO JULIAN FLORES MORENO; | 2024-07-01 |
| 150 | Posttranslationally Modified Fetuin-A in The Urine As A Marker for Rejection and Prediction of Graft Function in Renal Transplant Recipients, and Concurrent Correlation of Fetuin-A and Histopalogical Findings of Glomerulopathy in Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Kidney transplantation is the preferred treatment method for patients with chronic kidney disease. Standard parameters (estimated glomerular filtration, albuminuria) of renal function detection are limited by many factors, therefore they are considered insufficient. Urinary post-translationally modified fetuin A (uPTM-FeA) appears to be a promising biomarker for the early detection of impaired renal function. Increased values were detected in patients with diabetic kidney disease, acute kidney injury and interstitial fibrosis/tubular atrophy. Patients after kidney transplantation will be included in our analysis, … |
MATEJ VNUCAK; | 2024-06-25 |
| 151 | EASi-HF Preserved – A Phase III Double-blind, Randomised, Parallel-group Superiority Trial to Evaluate Efficacy and Safety of The Combined Use of Oral Vicadrostat (BI 690517) and Empagliflozin Compared With Placebo and Empagliflozin in Participants With Symptomatic Heart Failure (HF: NYHA II-IV) and Left Ventricular Ejection Fraction (LVEF) ≥40% PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empagliflozin helps people with heart failure. Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are: * Vicadrostat and empagliflozin group: participants take vicadrostat and empagliflozin as tablets once a day. * Placebo and empagliflozin group: participants take placebo and empagliflozin as tablets once a day. Participants can stay in the study as long as they benefit from treatment and can tolerate it. During this time, they visit their doctors regularly. The doctors regularly check participants’ health and take note of any unwanted effects. The study staff may also contact the participants by phone. Participants also regularly answer questions about their well-being. The study does not have a fixed duration. It continues until there is enough data to see if the treatment is working. |
BOEHRINGER INGELHEIM | 2024-06-17 |
| 152 | Preliminary Study of CXCL3 As A Biomarker of Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to learn about CXCL3 as a biomarker for type 2 diabetic kidney disease (DKD) in adults between age of 18-80. The main question it aims to answer is: – Is CXCL3 elevated in the serum or urine of type 2 adult DKD patients compared to normal control or diabetes mellitus without kidney involvement? – Is CXCL3 elevated in the mRNA of PBMC of type 2 adult DKD patients compared to normal control or diabetes mellitus without kidney involvement? – … |
THE FIRST HOSPITAL OF JILIN UNIVERSITY | 2024-06-10 |
| 153 | A Diagnostic System of Clincial Model and Urinary Biomarkers for Intrinsic Acute Kidney Disease PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational cross-sectional study is to develop a clinical diagnostic system for intrinsic acute kidney disease (AKD) to help clincians make non-invasive diagnosis when a kidney biopsy is not available. The main questions it aims to answer are: 1. Can a clinical model comprised of common clinical indexes help diagnose AKD ? 2. Can a combinition of several urinary biomarkers help diagnose AKD ? The study will be conducted in retrospective cohorts of patients with AKD undergoing kidney biopsy. The gold standard of the study is histological diagnosis of AKD. The model will be developed in a derivation cohort from one center, and will be further externally validated in a multicent cohort. The urinary biomarkers will only be tested in the derivation cohort. |
LI YANG; | 2024-06-01 |
| 154 | The Predictive and Prognostic Values of The Fibrinogen to Albumin Ratio and C-reactive Protien to Albumin Ratio in Systemic Lupus Erythematosus Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study was to study the predictive value of FAR and CAR in order to provide a new predictive biomarkers for the disease activity and prognosis. |
MANAR GAMAL MOHAMED; | 2024-06-01 |
| 155 | The Role of Toll-like Receptor-4 in Periodontitis Patients with End-stage Renal Disease in A Sample of Egyptian Population PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 [Gly/Thr (rs2149356)] polymorphism and chronic periodontal disease in ESRD patients in Egypt. |
FATMA ELSAYED; | 2024-06-01 |
| 156 | The Effect of Hand Massage with Violet Oil on Pruritus Level and Quality of Life in Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Itching is among the common problems in individuals receiving hemodialysis (HD) treatment. Research on the effects of aromatherapy on the symptoms seen in dialysis patients is increasing. Studies in the literature have found findings that aromatherapy reduces skin dryness and itching. This study was an experimental study with randomized intervention, placebo and control groups to determine the effect of a 7-minute massage with 2% violet oil on the hand on the non-fistula arm during the dialysis session, 3 times a week for six weeks, … |
KEVSER ÇAĞLA GURLAŞ; | 2024-06-01 |
| 157 | Association Between Biomarkers and Kidney Function Decline in Patients With Pulmonary Hypertension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH). |
FAEQ HUSAIN-SYED; | 2024-05-31 |
| 158 | Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The long-term objective of this study is to test whether the addition of SGLT2 inhibitors to usual care during acute heart failure management in patients who develop kidney injury shortens the time to achieving symptomatic improvement and kidney function recovery. The study aims to assess feasibility and acceptability of such a randomized clinical trial. |
ABINET AKLILU; | 2024-05-30 |
| 159 | Investigation of The Effectiveness of Respiratory Muscle Training in Children With Kidney Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease is defined as kidney damage lasting three months or longer and irreversible loss of renal function (glomerular, tubular and endocrine) or a glomerular filtration rate of less than 60 ml/min /1.73 m2 . Among the five stages of chronic kidney disease, the last and most severe stage is end-stage chronic kidney disease, which requires kidney transplantation. Many organs and systems are affected after kidney transplantation. Anemia, cardiovascular complications, secondary hyperparathyroidism, accumulation of uremic toxins, electrolyte disturbances, uremic myopathy, vitamin D deficiency, malnutrition, inflammation, atherosclerosis syndrome, … |
MELTEM KAYA; | 2024-05-27 |
| 160 | Increased Low-potassium Content Vegetables Consumption in Patients With Moderate-to-severe Chronic Kidney Disease: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prior observational studies have shown that higher levels of vegetables and fruits consumption are associated with lower risk of all-cause mortality in patients with chronic kidney disease (CKD). However, compared with the normal population, patients with CKD are more likely to consume less vegetables and fruits. Thus, the investigators aim to evaluate whether proving low-potassium content vegetables to this population are able to reach the recommended target of daily vegetables intake and not increase the risk of hyperkalemia. |
SZU-CHUN HUNG; | 2024-05-27 |
| 161 | CSP #2026 – Beta Blocker Dialyzability on Cardiovascular Outcomes (BRAVO) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability. |
VA OFFICE OF RESEARCH AND DEVELOPMENT | 2024-05-22 |
| 162 | EU Sites: Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS) (FASTR-EU) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve DMS system to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure (ADHF). The main objective is to determine if the Reprieve DMS is non-inferior to state-of-the-art urine sodium guided aggressive diuretic titration in two European HF centers of excellence. |
REPRIEVE CARDIOVASCULAR | 2024-05-17 |
| 163 | Finerenone Research of Outcomes and Drug Utilization PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study, in which data from people in Japan and in the United States with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied. The participants in this study are already receiving the study treatment finerenone as part of their regular care from their doctors. In observational studies, only observations are made without specified advice or interventions. CKD is a long-term progressive decrease in the kidneys’ ability to work properly. In people with T2D, the body does not make enough of a hormone called insulin, … |
BAYER | 2024-05-15 |
| 164 | Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this protocol is to assess the presence and severity of primary aldosteronism pathophysiology in patients with type 2 diabetes who have, or are at-risk for developing, chronic kidney disease. |
ANAND VAIDYA; | 2024-05-15 |
| 165 | Evaluating The Effect of Hemodialysis Modality and New Anti-glycemic Drugs on NETosis on in Hemodialysis and Diabetic Patient, and Assessment of NETosis in Various Kidney Diseases PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate whether new glucose-lowering medications, such as SGLT2 inhibitors (e.g., Forxiga/Jardiance) and GLP-1 receptor agonists (e.g., Ozempic), can reduce NETosis in diabetic patients, thereby mitigating secondary complications such as cardiovascular disease and kidney damage. By targeting dysregulated NET formation, the study seeks to establish a link between reduced NETosis and improved clinical outcomes in diabetes. Additionally, the study will evaluate the effects of immunosuppressive therapies on NETosis in patients with immune-mediated kidney diseases, such as ANCA-associated vasculitis. By correlating NETosis activity with disease progression and treatment response, … |
ETTY KRUZEL-DAVILA; | 2024-05-13 |
| 166 | Prevalence and Management Practice of Diabetic Kidney Disease at BADAS Affiliated Healthcare Centres in Bangladesh – An Exploratory Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Diabetes is a growing public health concern in Bangladesh, with millions affected. Diabetic Kidney Disease (DKD) is a severe complication of diabetes, affecting approximately 21.3% of the diabetic population. To address this issue, a comprehensive assessment of DKD within the Bangladesh Diabetic Association's (BADAS) affiliated healthcare centres is necessary. Objective: The study's general objective is to determine the prevalence of DKD and evaluate its management at BADAS-affiliated healthcare centers. Specific objectives include assessing risk factors, screening practices, disease staging, management approaches, patient education, and providing evidence-based recommendations. Methodology: – Study Design: Cross-sectional – … |
WASIM MD MOHOSIN UL HAQUE; | 2024-05-11 |
| 167 | A Phase IIb, Multicenter, Randomised, Double-Blind, Dose-finding Study to Evaluate The Efficacy, Safety and Tolerability of Balcinrenone in Combination With Dapagliflozin Compared With Dapagliflozin in Patients With Chronic Kidney Disease and Albuminuria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to evaluate the efficacy, safety and tolerability of balcinrenone/dapagliflozin compared with dapagliflozin alone on patients with chronic kidney disease (CKD) and albuminuria. This study will evaluate the effect of the balcinrenone/dapagliflozin on urinary albumin-to-creatinine ratio (UACR), compared with dapagliflozin in patients with CKD. This is a dose-finding study aiming to identify an optimal dose of balcinrenone/dapagliflozin for a future Phase III study in patients with CKD. |
ASTRAZENECA | 2024-05-01 |
| 168 | Predictors of Acute Kidney Injury in Critically Ill Children Admitted to Pediatrics Intensive Care Unit At Assiut University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Predictors of Acute Kidney Injury in critically ill children admitted to PICU during one year. |
MARTINA ADEL LABIB ATTIA; | 2024-05-01 |
| 169 | Social Virtual Reality to Alleviate Loneliness and Symptoms for Individuals Receiving Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial to compare the social virtual reality and individual virtual reality in patients with end stage kidney disease who are hemodialysis. The main aim is to determine if there are differences in symptoms between the groups. Participants will use virtual reality glasses for 30-45 minutes during dialysis sessions for 4 weeks. |
LEA ANN MATURA; | 2024-05-01 |
| 170 | Different Doses of Intravenous Administered Dexamethasone Effecting Brachial Plexus Supraclavicular Block for Creation of Arteriovenous Fistula in End Stage Renal Disease: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the analgesic properties of ultrasound guided supraclavicular block using ropivacaine 0.5% in arteriovenous fistula creation when used in combination with intravenous administered dexamethasone at 4mg and 8 mg as an adjuvant |
HOSPITAL UNIVERSITI SAINS MALAYSIA | 2024-05-01 |
| 171 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate The Effect of Retatrutide on The Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 Kg/m2 and Atherosclerotic Cardiovascular Disease And/or Chronic Kidney Disease PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor. |
PHILLIP MADONIA; | 2024-04-30 |
| 172 | Multicenter, Non-interventional Observational Prospective Study With Retrospective Analysis to Describe The Rate of CKD Diagnosis, in Patients With Arterial Hypertension and CKD Markers PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multi-centre, non-interventional, observational, prospective study with retrospective analysis. The main purpose of the study is to describe the rate of CKD diagnosis in patients with AH and CKD markers. This study will include 10 000 adult outpatients with arterial hypertension, who have one or more Chronic Kidney Disease laboratory markers (without recorded CKD diagnosis prior to enrolment) and have no diabetes mellitus or symptomatic chronic heart failure, … |
ASTRAZENECA | 2024-04-27 |
| 173 | A Phase 1/2a Dose-Escalating Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of ARO-CFB in Adult Healthy Volunteers and Adult Patients With Complement-Mediated Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of AROCFB-1001 is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ARO-CFB Injection in adult healthy volunteers (HVs) and in adult patients with complement-mediated kidney disease (IgA Nephropathy \[IgAN\]). In Part 1 of the study, HVs will receive either one or two doses of ARO-CFB or placebo. In Part 2 of the study, adult patients with IgAN will receive 3 open-label doses of ARO-CFB. Dose levels in Part 2 will be determined based on cumulative safety and pharmacodynamic data from Part 1. |
CHRISTIAN SWABE; | 2024-04-22 |
| 174 | Assessing The Risk of Chronic Kidney Disease Associated With Metabolic Dysfunction-Associated Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This cross-sectional study of 300 participants investigates the risk of chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) and type 2 diabetes. By evaluating hepatic measurements and metabolic markers, the study aims to identify key risk factors for CKD in this population, contributing valuable insights to inform targeted interventions. |
AHMED MAHMOUD ISMAIL; | 2024-04-20 |
| 175 | Study of The Effect of Demethylating Agent Azacitidine on Prevention of Acute Kidney Injury-chronic Kidney Disease Continuum PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute kidney injury (AKI) is increasing worldwide in recent years and is a major risk factor of chronic kidney disease (CKD). AKI, acute kidney disease (AKD) and CKD form a continuum whereby initial kidney injury leads to ongoing renal injury and eventually end-stage renal disease if no effective treatment is applied. Nevertheless, there are no useful pharmacotherapies approved clinically for the treatment of AKI and subsequent CKD. Previous studies of the investigators have confirmed that pericytes are the primary cell source of scar-producing myofibroblasts. Furthermore, … |
YU HSIANG CHOU; | 2024-04-18 |
| 176 | Feasibility Study of An Internet Based Education and Support Program for Patients Awaiting Kidney Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to test the feasibility study of an internet based education and support program for patients awaiting kidney transplantation. The study is designed as a national pilot randomized controlled trial with a waitlist control group, to test the feasibility, acceptability, and potential effects of the intervention on patients’ physical and mental health. |
KRISTINA NILSSON; | 2024-04-18 |
| 177 | Effects of Beetroot Extract Supplementation Associated With An Exercise Protocol on Oxidative Stress, Inflammation, and Functional Capacity in Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) patients often present systemic inflammation and oxidative stress, resulting in metabolic disorders and high rates of disease-associated cardiovascular death. The literature has indicated that dietary control, the use of bioactive compounds, and the practice of regular physical exercise are essential for the prevention and management of CKD and its complications. In this context, beetroot (Beta vulgaris rubra) deserves attention as it is a source of several bioactive compounds, such as nitrate, betaine, and betalain, with beneficial effects for CKD patients, including anti-inflammatory, antioxidant effects, reduction of blood pressure, and vasodilatory action. The antioxidant and anti-inflammatory properties, … |
DENISE MAFRA; | 2024-04-10 |
| 178 | Evaluation of A Multidisciplinary Care Pathway on The Evolution of Renal Function in Patients With Advanced Chronic Kidney Disease PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The number of incident and prevalent patients with end stage renal disease on dialysis treatment is increasing in France and worldwide. A quarter of dialysis patients are initiating dialysis urgently through central venous catheters and the number of patients registered in the waiting list for renal transplantation before dialysis initiation is very low. This is also reflected in the very low number of pre-emptive renal transplantations. In order to reduce the number of dialysis patients, … |
HÉLÈNE PAGES; | 2024-04-09 |
| 179 | Tobacco Exposure and Influencing Factors of Smoking Cessation Among Chronic Kidney Disease Patients: A Cross-Sectional Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to describe the tobacco exposure and characteristics of patients with Chronic Kidney Disease (CKD) who quit smoking, to identify patients’ tobacco-related knowledge, attitude, and practice (KAP) and explore the influencing factors of smoking cessation. |
WEI XIA; | 2024-04-05 |
| 180 | The Effect of Artificial Intelligence Supported Mobile Learning Developed for Hemodialysis Patients on Nutrition/Fluid Intake Control and Individual Management PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The adherence to recommended nutrition and fluid restrictions is crucial for the success of hemodialysis treatment. However, approximately 80% of patients receiving HD treatment are non-compliant with fluid restriction, leading to various complications. Cardiovascular complications are among the most common complications associated with this issue. When reviewing national and international literature on the subject, it is observed that in order to improve treatment adherence in HD patients, written materials are often used in addition to individual or group education sessions, focusing mainly on assessing patients' quality of life and self-efficacy. However, … |
SEVDA TÜZÜN ÖZDEMIR; | 2024-04-04 |
| 181 | Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema 2.4 Mg/2.4 Mg) Once Weekly Versus Semaglutide 2.4 Mg, Cagrilintide 2.4 Mg and Placebo in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look if CagriSema can lower kidney damage in people with chronic kidney disease (CKD), type 2 diabetes (T2D) and overweight or obesity. CagriSema is a new investigational medicine. CagriSema cannot yet be prescribed by doctors. The study will compare CagriSema to the 2 medicines semaglutide and cagrilintide, when they are taken alone. It will also compare CagriSema to a dummy medicine (also called placebo) without any active ingredient. Participant will either get CagriSema, semaglutide, … |
NOVO NORDISK | 2024-04-01 |
| 182 | Effects of Ziltivekimab Versus Placebo on Heart Failure Symptoms and Physical Function in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks like the study medicine but does not contain any medicine). The treatment participants get is decided by chance. Participant’s chance of getting ziltivekimab or placebo is the same. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine that doctors cannot prescribe. The study is expected to last for up to 1 year and 4 months. |
NOVO NORDISK | 2024-04-01 |
| 183 | Renal Resistive Index As A Predictor of Acute Renal Impairment in High-risk Patients Admitted to Surgical Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To study the ability of RRI, measured by bedside Doppler ultrasound, in detecting acute kidney injury in high-risk patients admitted to surgical intensive care unit, Aswan university hospital, compared with renal biomarkers and conventional assessment using urine output and serum creatinine levels. |
SOUDY SALAH HAMMAD; | 2024-04-01 |
| 184 | Investigating The Prevalence of Hyper Kyphosis and Forward Head Posture in Dialysis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate and compare the prevalence of forward head , hyper kyphosis and balance in hemodialysis and peritoneal dialysis patients. The main questions it mains to answer are: What is the prevalence of forward head posture in hemodialysis and peritoneal dialysis patients? What is the prevalence of hyper kyphosis in hemodialysis and peritoneal dialysis patients? Is there any relation between postural abnormalities and physical function in hemodialysis and peritoneal dialysis patients? Participants will answer 2 questionnaires and will do some functional tests. |
MOHAMMAD ALI TABIBI; | 2024-04-01 |
| 185 | A Pilot to Develop and Test An Interactive Computer-adaptive Chronic Kidney Disease Education Program for Hospitalized African American Patients (I-C-CKD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot clinical trial is to evaluate a culturally tailored computerized education program in hospitalized African-American patients with advanced chronic kidney disease (CKD). The main question it aims to answer are: does computerized adaptive education (CAE) increase patients’ knowledge about CKD self-care and renal replacement therapy (RRT) options compared to usual care (UC) and will CAE will be increase patients’ intent to participate in CKD self-care and RRT preparation compared to UC |
UNIVERSITY OF CHICAGO | 2024-04-01 |
| 186 | Bright Light Therapy to Treat Fatigue in End Stage Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to test light therapy in patients with end stage kidney disease who are receiving hemodialysis. The main aim is to determine if light therapy decreases fatigue severity. Participants will receive light therapy using special glasses for one hour during the dialysis sessions for four weeks of treatment. |
LEA ANN MATURA; | 2024-04-01 |
| 187 | Orthostatic Hypotension and Blood Pressure Variability in Persons Undergoing Hemodialysis – An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: High blood pressure is a risk factor for end-stage renal disease and is common in patients undergoing maintenance hemodialysis. Intradialytic hypotension is associated with an adverse prognosis. More knowledge is needed to identify patients at high risk for intradialytic hypotension and dialysis-associated hypotensive episodes. The aim of this observational single-center pilot study is to evaluate whether point-of-care ultrasound measurements may predict intradialytic hypotension and orthostatic blood pressure falls, in patients with chronic kidney disease who undergo maintenance hemodialysis. |
MAGNUS WIJKMAN; | 2024-04-01 |
| 188 | The Factors Affecting IPP in Peritoneal Dialysis Patients with Polycystic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Polycystic kidney disease (PKD) is the most common hereditary kidney disease. Peritoneal dialysis (PD) in such patients is restricted because the significantly enlarged kidneys and liver may lead to the increase of intraperitoneal pressure (IPP). Increased IPP points to higher risk of abdominal wall complications and limited infusion volume that cause insufficient dialysis adequacy. Therefore, monitoring IPP is especially important in patients with polycystic kidney disease. However, the standard measurement of IPP is limited due to its cumbersome procedures, … |
PEKING UNIVERSITY FIRST HOSPITAL | 2024-04-01 |
| 189 | Inorganic Pyrophosphate Homeostasis (PPi) in Pediatric Chronic Kidney Disease – PPi-DIA PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigator aim to identify the role of inorganic pyrophosphate and other anti-calcifying molecules in vascular disease in children with chronic kidney disease, with a view to developing therapeutic approaches aimed at limiting the onset of vasculopathy. |
CENTRE HOSPITALIER UNIVERSITAIRE DE NICE | 2024-04-01 |
| 190 | A Phase III, Randomised, Double-Blind, Active-controlled Study to Assess The Efficacy, Safety and Tolerability of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on Chronic Kidney Disease (CKD) Progression in Participants With CKD and High Blood Pressure PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to measure the efficacy and safety of baxdrostat/dapagliflozin in participants ≥ 18 years of age with CKD and HTN. This study consists of a screening, a 4-week dapagliflozin run-in period for participants naïve to SGLT2i at baseline; a 24-month double-blind period in which participants will receive either baxdrostat/dapagliflozin or dapagliflozin; and a 6-week open-label period in which all participants will discontinue baxdrostat/placebo and receive dapagliflozin alone. Site visits will take place at 2-, 4-, 8-, and 16- weeks following randomisation. Thereafter visits will occur approximately every 4 months, … |
ASTRAZENECA | 2024-03-29 |
| 191 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of Ravulizumab in Adult Participants With Immunoglobulin A Nephropathy (IgAN) PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study to evaluate efficacy of ravulizumab compared with placebo on proteinuria reduction and change in eGFR in adult participants with IgAN who are at risk of disease progression. |
ALEXION PHARMACEUTICALS | 2024-03-29 |
| 192 | A Regulatory Non-interventional Study to Monitor The Safety and Efficacy of JARDIANCE® (Empagliflozin 10 Mg) in Korean Patients With Chronic Kidney Disease (CKD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective is to monitor the safety profile of JARDIANCE® in Korean patient with chronic kidney disease (CKD) in routine clinical practice. The secondary objective is to monitor the efficacy of JARDIANCE® by evaluating changes in urine albumin-creatinine ratio (UACR) after 12 and/or 24 weeks of treatment. |
BOEHRINGER INGELHEIM | 2024-03-29 |
| 193 | FLAME-ASCVD-Nephro A Multinational Survey-based Study to Understand The Real-world Awareness and Perceptions of Systemic InFLAMmation and RolE of HsCRP As A Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Nephrologists PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this survey is to collect information for scientific research and to better understand the role of systemic inflammation in identification, treatment and management of patients with Atherosclerotic Cardiovascular Disease (ASCVD) and Chronic Kidney Disease (CKD) |
NOVO NORDISK | 2024-03-26 |
| 194 | An Interactive, Conversational Virtual Healthcare Agent to Educate and Engage Patients With Advanced Chronic Kidney Disease About Transplantation (Part 2: Pilot) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To develop, pilot, and refine a virtual healthcare agent that will educate patients with advanced chronic kidney disease and their caregivers about kidney transplantation. |
VISHNU POTLURI; | 2024-03-26 |
| 195 | Fibrinogen to Albumin Ratio As A Predictive Biomarker for Lupus Nephritis (LN) PF:2 Related Papers Related Patents Related Grants Related Experts View Abstract: Systemic lupus erythematosus is a chronic autoimmune disease often coexists with other diseases and damages multiple organs such as kidney liver nervous system and so on. Lupus … |
AHMED MAMDOUH MOHAMED FARES; | 2024-03-20 |
| 196 | A Feasibility Trial of A Stakeholder-Enhanced, Lay-Navigator-Delivered Intervention to Improve The Decisional Partnership of Chronic Kidney Disease Dyads PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We seek to explore the feasibility and acceptability of participation in a decision-support training program led by lay navigators. ImPart-Multi, an education-telehealth-based, is designed to empower Black chronic kidney disease patients (CKD) patients and their care partner to seek the resources and support needed to be activated allies when making health-related decisions. Participants, based on random assignment, will participate in survey completion at study start and at 12 and 24 weeks of enrollment, and will complete 1, 3, … |
SHENA GAZAWAY; | 2024-03-20 |
| 197 | Middle-aged Women With Adverse Pregnancy Outcomes and Heart Failure With Preserved Ejection Fraction PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Due to the steady increase in the burden of HFpEF, especially in women, it is an important task to search for new markers and early predictors associated with the development of this disease. Nowadays, the relationship of adverse pregnancy factors with the development of long-term cardiac pathology, in particular, HFpEF, … |
MAX SHPERLING; | 2024-03-18 |
| 198 | The Effect of Synchronous Home Based Tele Exercise on Physical Function, Daily Physical Activity and Frailty in Dialysis Patients: A Randomized Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of the trial is to assess key areas of uncertainty regarding the use of synchronous home-based tele exercise in future practice and research, including issues relating to feasibility, safety and potential for efficacy. |
BOBBY CHEEMA; | 2024-03-15 |
| 199 | A Phase 1, Multi-center, Open-label, Single-dose Study to Assess The Pharmacokinetics of Mezigdomide (BMS-986348, CC-92480) in Adult Participants With Normal Renal Function, Severe Renal Impairment, and End-stage Renal Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the drug levels of mezigdomide in participants with renal impairment. |
CELGENE | 2024-03-15 |
| 200 | The Potential Impact of Probiotic Supplementation on Trimethylamine-N-Oxide Plasma Level in End Stage Renal Disease Patients Undergoing Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if probiotic has an effect on Trimethylamine-N-Oxide Plasma Level in plasma, which represent strong risk factor for Atherosclerosis in end stage renal disease patients who undergoing hemodialysis the main questions to answer are : Does probiotic lower Trimethylamine-N-Oxide concentration? does probiotic participating in decreasing risk of atherosclerosis in end stage renal disease patients undergoing hemodialysis ? research will compare between patients who are taking probiotic and control group (taking no drug) participants will take probiotic for 3 months visit the clinic once every 2 weeks for checkups and tests All Patients will be subjected to the following: 1. Informed consent. 2. Demographics and history taking: Using Patient Data sheet. 3. Laboratory evaluation including: Kidney function tests: blood urea,serum creatinine, albumin ,uric acid. Complete blood count (CBC). C-reactive protein (CRP). |
NEHAL KAMAL BAZID; | 2024-03-15 |
| 201 | Design and Development of Health Monitoring System on Quality of Life, Self-management and Self-efficacy Among Patients Undergoing Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: One of the goals in the Sustainable Development Goals (SDGs) is the availability of a healthy and prosperous life for all ages. This goal mentions health priorities i.e. non-communicable diseases. Chronic kidney failure (CRF) is one of the non-communicable diseases that is the main cause of death and disability both in the world and in Indonesia. The prevalence of CRF in Indonesia is 0.5% with 83.2% of patients being of productive age and the highest number of CRF patients in North Kalimantan, Southeast Sulawesi, … |
ERNA ROCHMAWATI; | 2024-03-15 |
| 202 | SGLT2i in Diabetic Patients with Renal Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Post-transplant diabetes mellitus (PTDM), previously known as New Onset Diabetes After Transplantation defined as the diagnosis of diabetes mellitus (DM) in a previously non-diagnosed diabetic person after transplantation. PTDM is a common and serious post-transplant complication that threatens graft survival, increases incidence of infection and development of cardiovascular complications The primary objective of this study is to assess efficacy and safety of dapagliflozin in patients with post-transplantation diabetic patients |
AIN SHAMS UNIVERSITY | 2024-03-15 |
| 203 | Potential Effect of Niacin on Lipoprotein (a) Concentration and Hyperphosphatemia in End-Stage Renal Disease Patients Undergoing Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn if Niacin has an effect on lipoprotein (a) concentration and hyperphosphatemia, which represent strong risk factors for cardiovascular diseases, in End-stage renal disease (ESRD) patients undergoing hemodialysis. It will also learn about the safety of Niacin. The main questions it aims to answer are: – Does Niacin lower lipoprotein (a) concentration? – … |
AMIRA REDA MUHAMMAD GALAL; | 2024-03-15 |
| 204 | A Randomized Comparison of Cleerly Coronary Artery Disease Stage-Based Care Versus Risk Factor-Based Care for Primary Prevention of Cardiovascular Events PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease (CAD) Staging System-based care strategy reduces CV events compared with risk factor-based care. |
STEVE SIMON; | 2024-03-06 |
| 205 | A Phase II Clinical Study of Efficacy and Safety of HRS-1780 Tablets and Henagliflozin Proline Tablets in The Treatment of Patients With Chronic Kidney Disease (Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Design) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this study was to evaluate the efficacy of HRS-1780 tablets or Henagliflozin Proline tablets in patients with chronic kidney disease by evaluating UACR change from baseline to Week 13 |
SHANDONG SUNCADIA MEDICINE | 2024-03-02 |
| 206 | Predictors of Chronic Kidney Disease Among Type 2 Diabetic Patients in Assiut University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Predictors of Chronic Kidney Disease among Type 2 Diabetic Patients in Assiut University Hospitals. |
MUHAMMED ALI ABOALSAUD; | 2024-03-01 |
| 207 | Efficacy and Safety of Incorporating Sodium-glucose Cotransporter-2 Inhibitors to Regimens of Diabetes Patients Already Receiving Therapy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To detect the efficacy of SGLT2i in improving the metabolic parameters in patients with type 2 diabetes. – To detect the side-effects of SGLT2i |
CAROLINE REFAAT LABIB; | 2024-03-01 |
| 208 | Chronic Pain in Patients With Chronic Kidney Disease in Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pain is one of the most common symptoms among patients with End Stage Renal Disease (ESRD), and often goes unrecognized or inadequately managed in hemodialysis patients. More than 50% of patients undergoing hemodialysis suffer from pain, with 75% of them being treated ineffectively due to healthcare professionals' lack of awareness of this symptom. Therefore, pain management in this population is a complex and challenging task for healthcare providers. The most prevalent pain syndromes in hemodialysis patients include musculoskeletal disorders, metabolic neuropathies, … |
EVA SEGURA ORTÍ; | 2024-03-01 |
| 209 | Lumasiran in Hyperoxalaemic Patients on Haemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at how well a drug that reduced the amount of oxalate in the body works in patients that have kidney disease and need dialysis treatment. People with kidney disease often have higher levels of oxalate in the blood. People with kidney disease are also at higher risk of having heart attacks, … |
GERLINEKE HAWKINS-VAN DER CINGEL; | 2024-03-01 |
| 210 | Does Virtual Reality Improve Symptom Burden in Dialysis Patients? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the use of virtual reality therapy in dialysis patients. The main question it aims to answer is: Does virtual reality improve symptom burden in dialysis patients and improve their mental wellbeing? Over a period of one month, one virtual reality therapy session of 30 minutes will be performed during each regular hemodialysis session. Since we will conduct a monocentric, crossover randomized controlled trial, the participants act as their own control group. |
DAVID BLUM; | 2024-03-01 |
| 211 | The Association of Kidney Uptake at F-18 FDG PET/CT Studies and Renal Function Status PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Searching for a possible correlation between renal uptake at F-18-FDG PET/CT and renal functional parameters in both normal subjects and patients with CKD. |
RANA MAHMOUD FARGHALI; | 2024-03-01 |
| 212 | The Effect of Foot Reflexology and Therapeutic Touch on Fatigue, Depression and Quality of Sexual Life in Women Receiving Hemodialysis Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to examine the effects of foot reflexology and therapeutic touch on fatigue, depression and sexual quality of life in women receiving hemodialysis treatment. Hemodialysis treatment may have negative effects on the quality of sexual life and mental health of female patients. In this context, understanding the potential healing effects of foot reflexology and therapeutic touch on sexual health and fatigue and depression in these individuals may contribute to the development of more effective support and treatment strategies. |
CANSU AĞRALI; | 2024-02-27 |
| 213 | A Parallel-group, Randomized, Prospective, Interventional, Double-blind, Multicenter Global Phase 3 Study to Investigate The Efficacy and Safety of Finerenone Versus Placebo, in Addition to Standard of Care, in Participants With Chronic Kidney Disease and Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Researchers are looking for a better way to treat people with chronic kidney disease (CKD), a progressive decrease in the kidneys’ ability to work properly, and type 1 diabetes. In people with type 1 diabetes, the body does not make enough of a hormone called insulin, resulting in high blood sugar levels that can cause damage to the kidneys. CKD often occurs together with or as a consequence of type 1 diabetes. The study treatment finerenone works by blocking certain proteins, … |
BAYER | 2024-02-26 |
| 214 | Pregnancy and Contraception Education in Chronic Kidney Disease (PACE-CKD): A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This pilot study will assess the efficacy of a pregnancy and contraception education decision aid (DA) for patients with chronic kidney disease to support decisions about reproductive health, and will assess feasibility and acceptability of the intervention to inform future Research Project Grant (R01) level studies. |
ANDREA OLIVERIO; | 2024-02-14 |
| 215 | The SEAPORT 1 Study: An Open-label Exploratory Study to Evaluate The Safety, Pharmacokinetics, and Pharmacodynamics of INZ-701 in Study Participants With End-Stage Kidney Disease Undergoing Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if multiple doses of INZ-701, given once per week over 4 weeks are safe and increase pyrophosphate (PPi) levels in hemodialysis-dependent (HD) end stage kidney disease (ESKD) study participants who have low PPi levels. In addition, the effect of hemodialysis on the pharmacokinetics of INZ-701 and PPi levels will be evaluated. |
INOZYME PHARMA | 2024-02-12 |
| 216 | A National, Multicenter, Prospective, Observational Study to Assess Patient Characteristics, Treatment Algorithms and Disease Management of Hyperkalaemia Patients With Chronic Kidney Disease or Under Dialysis or With Heart Failure, Treated With Sodium Zirconium Cyclosilicate in Greece PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, observational, prospective, national study which includes patients with chronic kidney disease (CKD) under dialysis or not, or with heart failure (HF), treated with sodium zirconium cyclosilicate (SZC) as per Summary of Product Characteristics (SmPC), aiming to collect information on patient characteristics, routine clinical practice and treatments administered for managing hyperkalaemia in a real-world setting in Greece. It will include approximately 12 public hospital and clinic based nephrology, or cardiology sites throughout the country. Sites and investigators will be selected so to represent the management of patients with CKD under dialysis or not, … |
ASTRAZENECA | 2024-02-09 |
| 217 | Pilot Study for The Early Detection of Chronic Kidney Disease, Non-Dialysis Objective (NDO) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) is a significant public health problem worldwide, affecting more than 10% of the Spanish population. Early detection is considered a top healthcare priority to establish strategies for preventing progression to more advanced stages of the disease and its complications. Additionally, CKD is associated with high comorbidity, poor prognosis, and substantial resource consumption within the healthcare system. In this context, albuminuria may be a more sensitive marker of CKD than reduced glomerular filtration rate (GFR), and it is also considered an indicator of not only renal damage but also "systemic damage" (generalized endothelial dysfunction, arterial remodeling, … |
DIDIER SÁNCHEZ OSPINA; | 2024-02-01 |
| 218 | Assessment of The Frequency of Fundus Fluorescein Angiography Relationship With Contrast Nephropathy and Associated Factors PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: After the use of iodinated contrast agents, there is a risk of developing contrast nephropathy. Limited data in the literature are available on the incidence of contrast nephropathy after fluorescein angiography (FFA), which is an iodine-free organic contrast. Additionally, factors associated with contrast nephropathy after FFA are not clearly understood. Our study aims to evaluate these points. |
NUR SENA ÇOBAN; | 2024-02-01 |
| 219 | The Impact of Hyperkalemia-Induced ECG and ECHO Findings on Early and Late Mortality in Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with CKD ( eGFR < <60 mL/min/1,73 m2) presenting to emergency department with isolated hyperkalemia will be study population. Pre and post treatment ECG and echocardiographic findings will be recorded. Investigator will not intervene with the treatment decision of responsible physician and will not delay any intervetion or treatment for the sake of study. Data will be compared in terms of ECHO and ECG findings depending on hyperkalemia level and response to treatment. |
GULSEN AKCAY; | 2024-02-01 |
| 220 | Evaluation of A Multidisciplinary Care Pathway on The Evolution of Renal Function in Patients With Advanced Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The number of incident and prevalent patients with end stage renal disease on dialysis treatment is increasing in France and worldwide. A quarter of dialysis patients are initiating dialysis urgently through central venous catheters and the number of patients registered in the waiting list for renal transplantation before dialysis initiation is very low. This is also reflected in the very low number of pre-emptive renal transplantations. In order to reduce the number of dialysis patients, … |
PAGES HELENE; | 2024-01-31 |
| 221 | A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Assess The Safety, Tolerability, and Preliminary Efficacy of Empagliflozin Among Patients Initiating Hemodialysis for The Treatment of End-Stage Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A 12-week, phase II, randomized, double-blind, placebo-controlled, multi-center study to assess the safety, tolerability, and preliminary efficacy of empagliflozin versus placebo among patients initiating hemodialysis (n=60) for the treatment of end-stage kidney disease. |
DAVID CHARYTAN; | 2024-01-31 |
| 222 | A Randomized Controlled Feasibility Trial Evaluating The Implementation of Digital Dyadic Empowerment Program (DDEP) on Lifestyle Modification for Chronic Kidney Disease Management PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled feasibility trial conducted on patients with Chronic Kidney Disease (CKD) and their significant other |
MIAOFEN YEN; | 2024-01-29 |
| 223 | Clinical Validation of A Continuous Flow Peritoneal Dialysis System With Dialysate Regeneration PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this first-in-human clinical trial is to examine the safety and efficacy of treatment with a new peritoneal dialysis (PD) device called WEAKID (WEarable Artificial KIDney for peritoneal dialysis). This device, unlike conventional PD, … |
K.G.F. GERRITSEN; | 2024-01-22 |
| 224 | Targeting Trimethylamine N-Oxide for Cardiovascular Health In Liver Transplant Recipients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite medical and surgical advances, long-term survival in liver transplant (LT) recipients is compromised by an increased risk of cardiovascular disease (CVD) after transplant, the mechanisms of which are still not fully understood. TMAO is an attractive therapeutic target to improve vascular health and diastolic function toward preventing CVD in LT patients. Therefore, the purpose of this study is to better understand the role of TMAO in cardiovascular dysfunction patients with chronic kidney disease. |
DANIELLE KIRKMAN; | 2024-01-18 |
| 225 | A Phase 3, Open-label, Uncontrolled Study to Evaluate The Activity, Safety, Pharmacokinetics and Pharmacodynamics of Roxadustat for The Treatment of Anemia in Pediatric Participants With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Roxadustat is a licensed medicine to treat anemia in adults with chronic kidney disease (CKD). Anemia is a low level of red blood cells. Current treatment for anemia is to have injections of medicines called erythropoietin stimulating agents (also known as ESAs) to help the bone marrow make more red blood cells. These are often given together with iron. This treatment is also available to children and teenagers with CKD. However, there are some safety concerns with ESAs. Also, as roxadustat is taken orally, … |
ASTELLAS PHARMA GLOBAL DEVELOPMENT | 2024-01-16 |
| 226 | Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to better understand the effects of a sodium-glucose transport protein 2 inhibitor, dapagliflozin, added on to standard of care on heart and lung function and circulating metabolites (substances created when our bodies break down food, drugs, or its own tissues) in patients with chronic kidney disease. |
RUPAL MEHTA; | 2024-01-16 |
| 227 | Impact of Propionic Acid on Regulatory T Cell Function in Children With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Pro-Kids is a multi-center, double-blind, randomized and placebo-controlled intervention study in children with chronic kidney disease. The investigators address the effect of a dietary food supplementation of propionic acid on the immune system and the function of the intestinal barrier in CKD patients treated with hemodialysis. |
JOHANNES BENJAMIN HOLLE; | 2024-01-15 |
| 228 | Using Shared Decision Making to Improve Kidney Transplantation Rates PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to increase shared decision-making between dialysis providers and patients in order to increase patients’ probability of transplantation and to reduce socioeconomic/racial disparities in access to kidney transplantation. Participants will receive educational material over the course of 4-6 months about different aspects of the kidney transplant and waitlisting process. |
SUMIT MOHAN; | 2024-01-12 |
| 229 | Examining The Effect of The Peer Support Program Applied to Chronic Kidney Patients on Care Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main advantage of patient-to-patient peer counseling is that it benefits both the client and the peer mentors as real and authentic experiences are shared. Since both individuals go through similar experiences, they can share common feelings. Although there are studies in the literature showing the effectiveness of peer support groups in different patient groups, studies on chronic kidney disease patients are limited. There are no studies on the effects of these programs on caregivers. This study will be conducted to examine the effects of peer support program applied to chronic kidney patients on patient outcomes and caregivers. |
CANAN YÜKSEL ACAR; | 2024-01-11 |
| 230 | Oral Manifestations in Chronic Kidney Disease: Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to investigate oral manifestations in patients with Chronic Kidney Disease (CKD) for early detection, that alterations play an important point for dental guide during the progression and type of treatment of CKD . An oral exam was performed for detection oral manifestations, age, smoking, alcoholic and oral hygiene habits were collected. The study has 3 groups under study: hemodialysis (HD), peritoneal dialysis (PD) and pre-dialysis (P-D) |
JOSÉ LÓPEZ LOPEZ; | 2024-01-10 |
| 231 | Evolution of Proteinuria in Renal Transplant Patients Treated with Dapagliflozin for Nephroprotection. DAPAGREFFE PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The prevalence of chronic kidney disease is rising steadily and represents a major public health challenge. Hypertension and proteinuria are two factors strongly associated with the progression of chronic kidney disease (CKD) and the high risk of cardiovascular complications. Achieving blood pressure control and reducing proteinuria is therefore a major objective in the management of chronic renal failure. Until recently, inhibitors of the renin-angiotensin-aldosterone system were the only therapeutic class known to have both anti-proteinuric and anti-hypertensive action, … |
UNIVERSITY HOSPITAL MONTPELLIER | 2024-01-04 |
| 232 | Validation of Contrast Enhanced Ultrasound (CEUS) for The Assessment of Renal Perfusion Using Renal Magnetic Resonance Imaging (MRI) in Chronic Kidney Disease (CKD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Blood flow to the kidneys is important in the development of kidney diseases. Currently we do not have ways of measuring and monitoring kidney blood flow for patients in real-time. This is a major barrier to investigation and management of acute kidney injury (AKI) and chronic kidney disease (CKD). Kidney blood flow can be reliably measured using a specialised type of MRI scan, but this is expensive and difficult to do in people who are unwell. Contrast-enhanced ultrasound (CEUS) is a new technique, … |
NICK SELBY; | 2024-01-02 |
| 233 | Parameters of The Recovery Time of Acute Kidney Injury in Critically Ill Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: the primary objective of this study is to identify and analyze parametrers affecting the time of recovery of AKI in critical ill patient ,Specifically, the study aims to: 1. to identify outcomes of critically ill patients who experienced AKI 2. Examine the relationship between demographic and clinical variables (e.g., age, gender, comorbidities) and outcome of AKI patient 3. follow Baseline characteristics and laboratory findings of the patients at the time of admission to the intensive care unit and affecting it at recovery time 4. Explore the association between psychosocial factors (e.g., depression, anxiety, … |
MOHAMED ABDELMONGY MOHAMED ZAYED; | 2024-01-01 |
| 234 | Incidence and Predictive Risk Factors of Acute Kidney Injury in Pediatric Polytrauma Patients Admitted to Assiut University Trauma Unit: A Cross-sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized pediatric patients and identify the risk, and severity of AKI. The results would aid the emergency physicians in the early identification of those at risk of AKI to establish a resuscitation strategy that aims at preventing AKI |
DOAA ATEF ALSAYED; | 2024-01-01 |
| 235 | Electroencephalographic Changes in Nonconvulsive Children With Chronic Renal Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) arises from many heterogeneous disease pathways that alter the function and structure of the kidney irreversibly, over months or years. The diagnosis of CKD rests on establishing a chronic reduction in kidney function and structural kidney damage. The best available indicator of overall kidney function is glomerular filtration rate (GFR), which equals the total amount of fluid filtered through all of the functioning nephrons per unit of time The definition and classification of CKD have evolved over time, … |
KHLOUD ABD-ELNASSER SALEH SEIF; | 2024-01-01 |
| 236 | The Safety and Effectiveness of Warfarin Vs Apixaban in Patients with Non-Valvular Atrial Fibrillation/ Venous Thromboembolism and End-Stage Kidney Disease on Dialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a retrospective study of End-Stage Kidney Disease (ESKD) patients on dialysis receiving apixaban or warfarin at Tawam Hospital [a tertiary care hospital in Al Ain, UAE]. The study aims to assess the appropriateness of prescribing apixaban and warfarin in this population and evaluate their safety and effectiveness. |
SAID NABIL; | 2024-01-01 |
| 237 | Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 As Biomarkers of Acute Kidney Injury in Children With Diabetic Ketoacidosis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Type 1 diabetes mellitus (T1DM) is a common, chronic, metabolic disorder that has significant consequences for physical and emotional development . The incidence of TIDM is steadily increasing in nearly all parts of the world by about 2-5% per year . Diabetic ketoacidosis (DKA) is the most serious complication of TIDM and results from metabolic abnormalities due to a severe deficiency of insulin or insulin effectiveness. Similar to diabetes, … |
BASSEM ELDABA HOSNY FARES; | 2024-01-01 |
| 238 | Evaluating Baseline Predictors Including Total Kidney Volume, of Chronic GFR Decline and Other Clinical Outcomes in Outpatients With ADPKD and Stage IV CKD on Chronic Treatment With Octreotide LAR: A Retrospective, Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In this observational, retrospective study we will primarily aim at evaluating the independent role of baseline clinical and laboratory parameters, including TKV, in the prediction of long term chronic GFR decline and other clinical outcomes and, secondarily, the relationships between GFR and TKV changes over time, in a cohort of ADPKD patients with Stage IV CKD on chronic treatment with octreotide LAR and routinely monitored with serial GFR, TKV and clinical evaluations, at the outpatient clinic of the Nephrology Unit of the Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy. |
MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH | 2024-01-01 |
| 239 | Phase IIa Clinical Trial of Tamibarotene in Patients With Autosomal Dominant Polycystic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Clinical trial of tamibarotene in patients with Autosomal Dominant Polycystic Kidney Disease |
REGE NEPHRO | 2023-12-22 |
| 240 | A Multicenter, Multidose, Study to Assess The Tolerability and Pharmacokinetics of Oxylanthanum Carbonate at Clinically Effective Doses in Patients With Chronic Kidney Disease on Dialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical study is to test the tolerability of oxylanthanum carbonate (OLC) in patients with chronic kidney disease on hemodialysis and have hyperphosphatemia (too much phosphorus in their blood). The main question it aims to answer is whether patients taking OLC for hyperphosphatemia are able to tolerate the drug. Participants will continue with their scheduled dialysis treatments and replace their current phosphate binder drug with OLC. |
UNICYCIVE THERAPEUTICS | 2023-12-15 |
| 241 | A Randomized, Crossover, Double Blind, Placebo Controlled, Phase 2 Study to Evaluate The Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors, in Adults with Hypertension and Chronic Kidney Disease with Albuminuria PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, double-blind (DB), placebo controlled, crossover study with a two-period, two-sequence (2×2) design evaluating the efficacy and safety of 25 mg QD lorundrostat (an aldosterone synthase inhibitor \[ASI\]) in addition to a SGLT2i for the treatment of hypertension in subjects with CKD and albuminuria while receiving stable treatment with an Angiotensin-converting enzyme inhibitor (ACEi) or an Angiotensin receptor blocker (ARB). Subjects will be at least 18 years old with hypertension, and mild to severe CKD with albuminuria at the Screening Visit. |
MINERALYS THERAPEUTICS | 2023-12-14 |
| 242 | Simultaneous Prospective Kidney Transplant Assessment in Combined Liver Kidney PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the study is to determine how much a persons kidney function recovers after receiving a simultaneous liver kidney transplant. The investigators will be contacting patients with kidney dysfunction with estimated GFR between 25 and 40 (not on dialysis treatment) who are listed to receive a simultaneous liver kidney (SLK) transplant to look at this function recovery. The investigators hope to develop a criteria based on GFR measurement, kidney function calculations from native kidneys vs transplanted kidney and compare the contributions, … |
MUHAMMAD YAHYA JAN; | 2023-12-08 |
| 243 | Kidney Health: Eat Well, Live Well: A Program to Reduce Kidney Injury and Early CKD Progression Through Nutrition & Empathetic Support From A Health Partner PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This two-arm, parallel randomized trial study will assess the efficacy of a 6-month (26 weeks) community-based program in reducing kidney injury (as Urine Albumin to Creatinine ratio, uACR), cardiovascular risk (as Hemoglobin A1C and blood pressure), mental health (as PHQ-8) and diet quality (as fruits and vegetables intake and Healthy Eating Index) in community-dwelling, low-income adults diagnosed with early chronic kidney disease (stages 2 or 3 and not on kidney replacement therapies) compared to educational materials and usual care alone. |
MANINDER KAHLON; | 2023-12-06 |
| 244 | Semaglutide for Dialysis-Treated Patients – A Glucose Time in Range Study- DIALYSIS-TIR Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will look at control of blood sugar levels in persons with type 2 diabetes mellitus currently on chronic dialysis. Researchers will compare blood sugar levels in people taking semaglutide to people taking dummy medicine. The treatment participants get will be decided randomly. Participants will need to inject the study medication once a week. The study will last for 1 year and a month. Participants will be asked to wear a sensor that measures blood sugar levels for a period of 10 days at five different time points during the study. |
ILDIKO LINGVAY; | 2023-12-05 |
| 245 | Prevalence of Non-alcoholic Fatty Liver Disease in Patients With Chronic Kidney Disease in Assiut PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to detect the prevalence of NAFLD in CKD patients The main question[s] it aims to answer are: – [question 1] prevalence of NAFLD in CKD patients. – [question 2] the relationship between NAFLD and CKD. |
MUHAMMAD AMEEN ABDELRADY ABDELAZIZ; | 2023-12-01 |
| 246 | Short Term Renal Outcomes Among Post Liver Transplantation Patients at Assiut University PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate Renal outcomes among patients, post liver transplantation at Assiut university. |
EBRAM MAGDY ESKANDER NASHED; | 2023-12-01 |
| 247 | The Risk Factors of Thrombosis in Complicated Arteriovenous Fistula in Patients on Regular Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: study the risk factors of thrombosis in thrombosed arteriovenous fistula in patients on regular hemodialysis |
MOHAMED ALDOSOUKY; | 2023-12-01 |
| 248 | Some Hematological Profile in Children With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is asses the hematological changes in children with chronic kidney disease stage 3 to 5 including – Complete blood picture – Coagulation profile (PT, PC, PTT) – Iron study |
ZEINAB OTHMAN ABDELGALEEL; | 2023-11-30 |
| 249 | Construction of A Theoretical Model of Medical Behavior of Patients With Chronic Kidney Disease From The Perspective of Supply: An Empirical Analysis Based on Andersen Behavior Model PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The impact of narrative nursing interventions on negative emotions, self-efficacy, quality of life in individuals undergoing maintenance hemodialysis |
ZHENG JIE; | 2023-11-29 |
| 250 | Chronic Kidney Disease Registry Platform Study PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, prospective, observational registry platform study which is designed to establish a CKD registry platform by collecting data on the demographics, etiology and staging, clinical characteristics, diagnostic and treatment patterns, and clinical outcomes of patients with chronic kidney disease (CKD), to describe the current status of the diagnosis and treatment of patients with CKD and the gaps from the diagnostic and treatment guidelines, explore the risk factors for disease progression and clinical outcomes in CKD patients, and construct a risk prediction model for CKD progression and clinical outcomes. |
BICHENG LIU; | 2023-11-28 |
| 251 | The Influence of Internet + Combined Family Empowerment Management Mode on Treatment Compliance of PATIENTS With CKD and The Relationship Between Psychological Status and Disease Progression PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To explore the effect of Internet + combined family empowerment management mode on treatment compliance of patients with chronic kidney disease (CKD) and the correlation between psychological status and disease progression. |
ZHENG JIE; | 2023-11-23 |
| 252 | A Phase 3, Randomised, Double-blind, Parallel-group, Event-driven, Cardiovascular Safety Study With BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity With Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, And/or at Least Two Weight-related Complications or Risk Factors for CVD PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is open to adults who are at least 18 years old and have a body mass index (BMI)bof 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related to their weight or risks of cardiovascular disease can participate. Participants must have previously tried to lose weight by changing their diet. The purpose of this study is to find out whether people with overweight or obesity who take a medicine called survodutide (BI 456906) are less or more likely to develop serious cardiovascular problems. It also aims to find out whether health parameters like blood pressure improve. Overweight and obesity are linked to cardiovascular disease. Survodutide is a medicine that is developed to help people with obesity or overweight to lose weight. Participants are divided into 3 groups of almost equal size. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under the skin once a week. All participants also receive counselling on diet and physical activity. Participants are in the study for up to 2 years and 3 months. During this time, it is planned that participants visit the study site up to 21 times and attend remote visits by video calls. During these visits, the doctors check participants’ cardiovascular and overall health. The results are compared between survodutide and placebo groups. The study staff also takes note of any unwanted effects. |
BOEHRINGER INGELHEIM | 2023-11-20 |
| 253 | UTRACT Jelmyto Registry: A Multicenter, Prospective and Retrospective Registry to Evaluate Real World Experience and Outcomes of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this registry is to evaluate real world experience and outcomes of patients with Upper Tract Urothelial Cancer (UTUC) treated with Jelmyto in the United States. |
YAIR LOTAN; | 2023-11-17 |
| 254 | Evaluation of The Effect of Finerenone on Renal Function in Patients With Type 2 Diabetes and Chronic Kidney Disease: A Prospective, Single-Arm, Multicenter Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Research Objectives To evaluate the impact of finerenone on renal function, diabetic complications, and safety in patients with Type 2 diabetes and chronic kidney disease. Study Design Type: Prospective, single-arm, multicenter clinical trial. Sample Size: 300 patients. Intervention: Finerenone added to existing treatment regimen (10-20 mg once daily, dose adjusted based on eGFR), for 48 weeks. Data Collection Time Points: Baseline, 4 weeks, 12 weeks, 24 weeks, 36 weeks, and 48 weeks. Primary Endpoint: Change in urine albumin-to-creatinine ratio (UACR). Secondary Endpoints: Changes in eGFR, 24-hour urine protein, serum uric acid, retinopathy markers, pulse wave velocity (PWV), ankle-brachial index (ABI), … |
XIE YING; | 2023-11-17 |
| 255 | Transient Elastograghy to Detect NAFLD in RTRs PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: a. Primary (main): The presence of non alcoholic fatty liver disease in post renal transplantation recipients by non invasive methods as transient elastograghy b-Secondary (subsidiary): to evaluate if transient elastograghy could be used as a noninvasive tool as new perspective on the prediction, prevention of non alcoholic fatty liver disease in renal trasplantation recipients . |
AMANY KHALED ALI AHMED; | 2023-11-01 |
| 256 | Virtual Home-based Multimodal Physical Pre-habilitation in Kidney Transplant Candidates: A Pilot RCT PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this RCT is to address the feasibility to conduct a multimodal physical pre-habilitation intervention in kidney transplant candidates. The main questions it aims to answer are: – estimate the proportion of screened patients who meet eligibility criteria – estimate the proportion of eligible patients who consent to randomization – estimate the proportion of patients who adhere to the interventions – estimate follow-up completion rates – inform the calculation of sample size requirements for a full-scale RCT – … |
TANIA JANAUDIS-FERREIRA; | 2023-11-01 |
| 257 | Intradialytic Aerobic Exercise in CKD Patient PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Intradialytic aerobic exercise is not effective in increasing hemodialysis adequacy but is effective in improving physical performance in twice-weekly hemodialysis patients. |
IRMA RUSLINA DEFI; | 2023-11-01 |
| 258 | Incidince of Acute Kidney Injury in Children With Community Acquired Pneumonia at Assiut University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Descriptive prospective observational study of Incidince of acute kidney injury in children with community acquired pneumonia at assiut university children hospital |
MOHAMED MAHMOUD FATHY AHMED; | 2023-10-31 |
| 259 | Prevalence of Seroconversion of Hepatitis C Virus Among Children With Chronic Kidney Disease on Regular Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: observational cross sectional study for children with chronic kidney disease who on regular hemodialysis in assiut univeristy children hospital at dialysis unit, observe prevalence of serological seroconversion of hepatitis c virus and associated risk factors |
MAHMOUD MOHAMED ZEAWELA; | 2023-10-26 |
| 260 | Managing Opioid Related Sleep Apnea With Acetazolamide PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB). Treatment of SDB often consists of use of a device during sleep that provides continuous positive airway pressure (CPAP) via a mask interface. However, this device is not effective or tolerated in all individuals. The goal of this study is to examine whether a medication called acetazolamide can improve SDB, as an alternative to CPAP treatment. The investigators will measure the improvement in SDB, as well as any change in symptoms, … |
JEREMY ORR; | 2023-10-18 |
| 261 | Clinical Protocol REN-007E – Extension Study: An Evaluation of Patient Reported Outcomes and Clinical Outcomes Through 12 Months Post-Cardiac Surgery in Subjects Enrolled in Study REN-007 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This extension study is being conducted to assess the following objectives through 12 months post-cardiac surgery: * Patient reported outcomes (PRO), using the EQ-5D questionnaire * Clinical outcomes |
RENIBUS THERAPEUTICS | 2023-10-16 |
| 262 | Clinical Decision Tree Analysis of Hemodialysis Arteriovenous Access Choices and Creations – A Multiple-center Retrospective Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Our study aim was to utilize a decision tree analysis (DTA) model to gain insight into the decision-making process within a multiple-center cohort. |
CHIH-YANG CHAN; | 2023-10-13 |
| 263 | MoVE Trial: Motivational Strategies To Empower African Americans To Improve Dialysis Adherence PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: MoVE Trial is a randomized clinical trial designed to rigorously test the impact of a behavioral intervention (culturally tailored motivational interviewing – (MOVE)) delivered by trained health coaches, on hemodialysis treatment non-adherence. It is a a two-arm, parallel group randomized clinical trial with 24-week follow-up. It involves completion of surveys by patients enrolled in the study. It also involves participation in motivational interviewing sessions by patients who are randomized to the intervention (MI). |
EBELE UMEUKEJE; | 2023-10-09 |
| 264 | Cross-sectional, Non-randomized Observational Study to Assess The Frequency of Reduced Sodium Intake in The Primary Care Setting – LAXAP PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a cross-sectional epidemiological, observational study. It would be carried out in primary health care sites. The purpose of this study is estimating the percentage of patients aged 60 years or older who suffer from a condition, or take medication, associated with a low or sodium-free diet in primary care consultations. This is a cross-sectional epidemiological study of data collection without medication. Participants data will be collected after obtaining their confirmation through an Informed Consent From. No medication will be given to patients. |
SOLEDAD ESCOLAR LLAMAZARES; | 2023-10-03 |
| 265 | Tunisian Clinical Registry on Chronic Kidney Disease in Hypertensive Patients. National Multicentric Cross Section Survey PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: In Tunisia, high blood pressure (HTN) is a public health problem whose prevalence varies from 28.7% to 34.7%. Hypertension can be both, cause and consequence of chronic kidney disease, and its prevalence is quite high in this population. It is both a risk factor for mortality and cardiovascular morbidity, … |
AMEL HARZALLAH; | 2023-10-01 |
| 266 | Prevalence of Erthropoietin Stimulating Agents Hyporesponsiveness and Its Correlation With Cardiovascular Morbidities in Hemodialysis Patients in Assiut University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: – The prevalence of erthropoietin stimulating agents hyporesponsiveness in hemodialysis patients in Assiut university hospital – Assessment of cardiovascular diseases risk in patients with erythropoiesis stimulating agents hyporesponsiveness in hemodialysis patients in Assiut university hospital |
FEBY RASMY KHALIFA MAKAR; | 2023-10-01 |
| 267 | The Influence of The Thickening of Bowman’s Capsule on The Clinical Prognosis of Patients With Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetic kidney disease (DKD) is the leading cause for renal replacement therapy in developed country. DKD is also the primary cause of ESKD among middle-aged and elderly people in China. Renal pathological markers have been proved to have clinical and prognostic value in both non diabetic and diabetic kidney diseases. To discriminate lesions by various degrees of severity, the Working Group of the Renal Pathology Society (RPS) developed a pathologic classification for DKD in 2010. The classification is based on glomerular lesions, with a separate evaluation for interstitial and vascular lesions. In a decade, … |
RENJI HOSPITAL | 2023-10-01 |
| 268 | Frailty Trajectories and Effects of Personalized Actionable Connected Extensible (PACE) Interventions Among Patients With Chronic Kidney Disease: A Longitudinal Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized controlled trial study conducted on frail patients with chronic kidney disease(CKD). |
MIAOFEN YEN; | 2023-10-01 |
| 269 | An Alternative Approach to Fatigue and Comfort Levels in Hemodialysis Patients: Reiki Energy Therapy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic renal failure (CRF) is a chronic and progressive kidney disease caused by impaired metabolic and endocrine functions as a result of a decrease in glomerular filtration rate (GFR), the role of the kidney in maintaining fluid electrolyte balance. KRG, which has high mortality and morbidity, is defined as an important public health problem due to the fact that it also causes a great burden on health systems. Reiki is not an alternative to allopathic medicine; … |
MERVE TOPAC; | 2023-10-01 |
| 270 | Clinical Study Evaluating The Impact of Curcumin and Pentoxiphylline on Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate the impact of turmeric and pentoxiphylline on serum levels of protein-bound uremic toxin (p-cresyl sulfate), oxidative stress biomarker level (Malonaldehyde), inflammatory biomarker level (Highly sensitive C-reactive protein). In addition to the evaluation of its effect on metabolic profile and disease progression in chronic kidney disease patients. |
ALEXANDRIA UNIVERSITY | 2023-10-01 |
| 271 | Impact of Clinical Pharmacist Intervention on Medication Adherence and Its Association With Clinical Outcomes in Chronic Kidney Disease in Islamabad PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research study is to evaluate the impact of clinical pharmacist interventions on treatment outcomes, health-related quality of life (HRQoL),and medication adherence among chronic kidney disease patients. Pharmacist’s intervention aim to answer: 1. How a clinical pharmacist intervention program impact medication adherence in chronic kidney disease? 2. To assess how patients’ counseling and medication adherence impact patient health-related quality of life? 3. How a clinical pharmacist intervention program improves clinical outcomes of chronic kidney disease patients? |
MATTI ULLAH; | 2023-09-22 |
| 272 | Effect of An Educational Program on Dietary Adherence, Nutritional Knowledge, Nutritional Status, Metabolic Control and Quality of Life in Predialysis, Peritoneal Dialysis and Hemodialysis Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A fundamental strategy to improve adherence to nutritional treatment in patients with chronic kidney disease is the implementation of educational programs. The aim of this study is to evaluate the effect of a multidisciplinary educational program on dietary adherence, nutritional knowledge, nutritional status, metabolic control and quality of life in patients with chronic kidney disease, predialysis, peritoneal dialysis and hemodialysis. A randomized clinical trial will be carried out, in which patients who meet the inclusion criteria will be randomly assigned to three possible groups: predialysis educational intervention, dialysis educational intervention and control group. At the initial visit, … |
XIMENA ATILANO CARSI; | 2023-09-19 |
| 273 | Improving KIdney ¬Transplantation with Cellular Therapy Study Related Papers Related Patents Related Grants Related Experts View Highlight: The i-KITCaT study aims to harness cellular therapies to favourably alter the immunological response to in AKI in transplantation. Kidney transplantation offers the best survival and quality of life outcomes for patients with end-stage kidney disease but requires life-long immunosuppression. Efforts to increase the donor organ pool means accepting kidneys which have been subjected to medical and surgical factors culminating in acute kidney injury (AKI). There is no treatment to modify the maladaptive injury process following an AKI insult, and this subjects the new kidney to increased risk of needing dialysis in the first 7 days of transplantation, rejection, … |
JENNIFER LI; | 2023-09-19 |
| 274 | Determination of A Profile of Patients With Renal Failure to Be Supported As A Priority in The Care Pathway in Order to Avoid Emergency Hospitalizations PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to map the population of stage 4 and 5 kidney failure patients followed in consultation by the CHSF nephrology team and to determine the factors associated with recurrent hospitalizations. |
CHRISTINE BOUHELIER; | 2023-09-15 |
| 275 | An Integrated Pharmacokinetic and Safety Open-label Basket Trial of Daprodustat for The Treatment of Anemia Associated With Chronic Kidney Disease in Male and Female Children and Adolescents Aged 3 Months to Under 18 Years Requiring or Not Requiring Dialysis Related Papers Related Patents Related Grants Related Experts View Highlight: This is an international, multicenter trial, evaluating pharmacokinetics (PK) (4 weeks), safety (52 weeks), and hemoglobin (Hgb) response (52 weeks) to daprodustat in children and adolescent participants with anemia associated with chronic kidney disease (CKD) incorporating 2 independent sub-trials (Non dialysis \[ND\] and Dialysis \[D\]). This study will enroll participants with anemia associated with CKD, … |
GLAXOSMITHKLINE | 2023-09-06 |
| 276 | Prognostic Modeling of Heart Failure Risk in A Large-Scale Asian Cohort With Chronic Kidney Disease: The CKD-Heart Study PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Among patients with known chronic kidney disease (CKD) who are free from diagnosed heart failure (HF), some may be classified as stage A-B HF based on the contemporary 2022 ACC/AHA Guideline for Heart Failure Classification. Several key clinical features and risk factors have been shown to serve as predictors for future HF development. Importantly, compared to white populations, … |
CHUNG-LIEH HUNG; | 2023-08-21 |
| 277 | Supporting Self-Management of Healthy Behaviors Among People With Diabetes, Kidney Disease, and Hypertension (SMART-HABITS-4-Health): A Pilot Trial of A Blood Pressure Monitoring Intervention Leveraging Social Incentives and Gamification PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The planned intervention, entitled, Supporting Self-Management of Health Behaviors to Optimize Health (SMART-HABITS for Health), aims to provide support for patients with chronic kidney disease, hypertension and diabetes by providing text messages delivered as motivational reminders and support to encourage blood pressure self-monitoring through goal setting, customized task prompts via text message and feedback, leveraging social connections, and use of a gamification design. |
SARAH SCHRAUBEN; | 2023-08-21 |
| 278 | A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of RO7434656, An Antisense Inhibitor of Complement Factor B, in Patients With Primary IgA Nephropathy at High Risk of Progression PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of sefaxersen (RO7434656), a novel Antisense Oligonucleotide (ASO) therapy in participants with primary IgA nephropathy (IgAN) who are at high risk of progressive kidney disease despite optimized supportive care. |
HOFFMANN LA ROCHE | 2023-08-08 |
| 279 | Evaluation of Galectin 3 Level in Serum and Saliva of Pemphigus Patients and Its Correlation With Disease Severity and Systemic Comorbidities PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Assessment of the expression of galectin-3 in serum and saliva of pemphigus patients and compare it with age and sex matched controls. We want to detect whether a correlation exists between galectin-3 level in serum, as well as saliva and disease activity score by Autoimmune Bullous Skin Disorder Intensity Score (ABSIS). |
EMAN FATHY AHMED; | 2023-08-08 |
| 280 | Reducing Dietary Acid With Fruit and Vegetables Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD) Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Metabolic acidosis is a common problem that occurs with worsening chronic kidney disease. Dietary acid can build up when the kidneys are not working well. This can be associated with a higher risk of worsening kidney function and death. The usual treatment is a medication called sodium bicarbonate which works to balance the acids in the body. The medication however often does not work and causes side effects. Consumption of alkalizing fruit and vegetables may work as a treatment for metabolic acidosis. This trial is being done to see if fruit and vegetables, provided via home delivery, … |
DYLAN MACKAY; | 2023-08-04 |
| 281 | A Brief Patient Educational Video to Reduce Potentially Harmful Over-the-counter Nonsteroidal Anti-inflammatory Drug (NSAID) Use PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this study is to assess the efficacy of a brief 3 to 5-minute educational video on influencing intent to change behavior regarding potentially harmful over-the-counter (OTC) NSAID use in adults with chronic kidney disease (CKD), heart failure (HF), and/or hypertension (HTN). Informed by the COM-B model of behavior change, the video reviews identifying OTC NSAIDs, potential risks of NSAIDs, and general alternatives to potentially harmful NSAIDs. Participants with CKD, HF, … |
MICHELLE ROCKWELL; | 2023-08-02 |
| 282 | Predicting Acute Kidney Injury in Infants Exposed to Nephrotoxic Drugs: A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns ExpoSed to NephroTOxic Drugs. (NeoAKI STOP) PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This observational retrospective study aims to learn about the incidence of acute kidney (AKI) injury in newborns in infants exposed to nephrotoxic drugs with a big data approach. The main question it aims to answer are: – Develop a model that can predict the occurrence of AKI in infants admitted to the NICU; – … |
GIACOMO CAVALLARO; | 2023-08-01 |
| 283 | Clinical Outcomes of Dapagliflozin in Acute Heart Failure, A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to evaluate the short-term clinical outcomes of starting Dapagliflozin on the same day of hospital admission in patients with acute decompensated heart failure (ADHF). The main questions it aims to answer are: – Does early initiation of Dapagliflozin improve the length of hospital stay and in-hospital mortality in patients with ADHF? – Does early initiation of Dapagliflozin enhance the diuretic response, weight reduction and pro-BNP reduction in the acute stage of HF? – … |
HOSSAMELDIN ELSAYED KHALIFA HUSSEIN; | 2023-08-01 |
| 284 | The Impact of Oral Protein-based Supplements on Nutritional Status and Quality of Life in Hemodialysis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this work is to study the effects of oral protein-based supplements on nutritional status in hemodialysis patients |
MOHAMED MAMDOUH MAHMOUD MOHAMED ELSAYED; | 2023-08-01 |
| 285 | A Phase 1, Randomised, Placebo-controlled Study to Investigate The Safety, Tolerability, and Pharmacokinetics of Multiple Doses of 10 Mg/kg AD-214 When Administered Intravenously to Healthy Volunteers and Patients With Interstitial Lung Disease or Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a Phase I, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of a 10 mg/kg dose of AD-214 when administered to healthy volunteers (HVs) (Part A) or patients with interstitial lung disease (ILD) or chronic kidney disease (CKD) (Part B). The study will be performed in Australia at up to two clinical sites. |
EMIR REDZEPAGIC; | 2023-08-01 |
| 286 | Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, placebo-controlled, double-blinded crossover design. Fifteen healthy subjects will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid. After a period of 5-days treatment, effect variables will be measured (experiment day 1). After a washout period of 14 days, the subjects are crossed over to a similar treatment period with the other treatment. The study is terminated by measuring effect variables after the second treatment period (experiment day 2). |
TRINE LYKSHOLM; | 2023-08-01 |
| 287 | Comparison of Two Different External Clearance Markers for Measuring Glomerular Filtration Rate (GFR) – Mannitol and Iohexol, in Patients Treated in The Intensive Care Units and in Outpatients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: GFR is the best parameter of the real kidney function. Measurements, however are time-consuming and have limited capacity. Patients treated in the intensive care units often have more than one organ-insufficiency and acute kidney injury (AKI) has an incidence of up to 70 %. GFR changes dynamically and this is one of the reasons why GFR-measurements have limited indications on the ICU. Retention of medicines or their active metabolites, however can lead to side effects, toxicity and or prolonged ICU-stay. Moreover, patients with allergy to actually standard marker, contrast material iohexol, … |
KATALIN KISS; | 2023-08-01 |
| 288 | Preoperative Renal Resistive Index to Predict Long-term Development of Chronic Kidney Disease in Patients Undergoing Cardiac Surgery PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Renal resistive index (RRI) is calculated from ultrasonographic Doppler measurements of flow velocities in intraparenchymal renal arteries. Normal values are around 0.60, and 0.70 is considered the upper normal threshold in adults. Both preoperative and postoperative elevation of RRI has shown promise in early detection of AKI after cardiac surgery. Further, … |
DANIEL HERTZBERG; | 2023-08-01 |
| 289 | Effect on Contrast Induced Acute Kidney Injury of APX-115 in Subjects Undergoing Percutaneous Coronary Intervention A Randomized, Double-blind, Parallel Group, Multicenter, Multi-national Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This phase 2 study is to assess the safety and efficacy of APX-115 active doses in Contrast Induced Acute Kidney Disease compared to placebo following multiple oral dosing in patients with undergoing percutaneous coronary intervention. It is anticipated that approximately 280 patients will be randomized into the study in a 1:1 ratio to 400 mg APX-115 (Isuzinaxib hydrochloride) or placebo arm. |
APTABIO THERAPEUTICS | 2023-07-31 |
| 290 | InspeCKD – Secondary Data Analysis of Patients at Risk for Chronic Kidney Disease (CKD) in German Primary Care Offices to Inspect CKD Prevalence, Diagnosis Rates, Diagnostic Behaviour, Treatment Patterns and Patient Characteristics PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a national secondary data analysis to determine the prevalence of diagnosed and undiagnosed CKD in German primary care offices in a patient population at high risk for the development and progression of CKD. Furthermore, it addresses the question of how CKD screening, monitoring and treatment of these patients is conducted within the German primary care setting. |
ASTRAZENECA | 2023-07-26 |
| 291 | Effect of Urine-guided Intraoperative Hydration on The Incidence of Postoperative Acute Kidney Injury and Long-term Outcomes in Patients With Pseudomyxoma Peritonei Receiving CRS-HIPEC: A Prospective, Randomized, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute renal injury (AKI) is a common complication after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), and is associated with worse outcomes. Available evidences show that maintaining intraoperative urine output ≥ 200 ml/h by fluid and furosemide administration may reduce the incidence of AKI in patients undergoing cardiopulmonary bypass. The investigators hypothesize that, for patients undergoing CRS-HIPEC, intraoperative urine-volume guided hydration may also reduce the incidence of postoperative AKI. |
DONG-XIN WANG; | 2023-07-24 |
| 292 | A Phase 2b, Double-Blind Study to Investigate The Effect of Retatrutide on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to investigate the effect of retatrutide on renal function in participants with overweight or obesity and chronic kidney disease (CKD), with or without Type 2 Diabetes (T2D). The study will last around 31 weeks. |
YESSICA SACHDEVA; | 2023-07-20 |
| 293 | Does Protein Restriction Plus Essential Amino Acids and Keto-analogues Supplementation Have A Beneficial Effect on GFR Decline in CKD Patients? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the effect of protein restriction plus KA/EAA supplementation on GFR decline in CKD patients. |
MOHAMED MAMDOUH MAHMOUD MOHAMED ELSAYED; | 2023-07-20 |
| 294 | Development of A Core Outcome Set for Pharmacist-led Interventions in Chronic Kidney Disease: A Protocol for A Survey and E-Delphi Consensus Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background Chronic kidney disease (CKD) is a progressive condition characterised by a gradual reduction in kidney function and structure over time. CKD is a risk factor for other morbidity, where it not only increases the likelihood of all-cause and cardiovascular mortality, but also can have a detrimental impact on quality of life. Whilst several systematic reviews have demonstrated the benefits of interventions delivered by pharmacists, there is significant variability in terms of the outcomes reported and an inconsistency with the measures used (e.g., … |
THOMAS WILKINSON; | 2023-07-20 |
| 295 | Potential Effects of Non-surgical Endodontic Treatment on Periapical Healing, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients With Apical Periodontitis- Interventional Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this prospective study is to determine the effect of non-surgical root canal treatment in chronic kidney disease patients and healthy patients with apical periodontitis. |
HIMANSHI VERMA; | 2023-07-12 |
| 296 | A Phase 1, Open-label, Supplemental Dosing Study of Participants With Chronic Kidney Disease Previously Treated With REACT (REGEN-015) Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety of supplemental REACT injections in participants with chronic kidney disease (CKD) who have previously received REACT treatment. |
PROKIDNEY | 2023-07-11 |
| 297 | Correlation Between The Preoperative N-terminal Pro-B-type Natriuretic Peptide and Acute Kidney Injury After Abdominal Surgery: A Single Center Retrospective Cohort Study Based on ERAS Database PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Accurate preoperative AKI risk prediction is of great significance for improving patient outcomes. The use of preoperative NT-proBNP can provide a more precise assessment of the body’s fluid load status, guide intraoperative and postoperative fluid management, and thus reduce fluid related postoperative complications. Given the potential association between ERAS and increased postoperative AKI, we hypothesize that preoperative NT-proBNP may be associated with the development of postoperative AKI in ERAS, … |
CHONG LEI; | 2023-07-10 |
| 298 | An Observational Explorative Study to Determine Pharmacokinetic Changes of Ceftriaxone in Blood and Ascites in Patients Admitted With Decompensated Liver Cirrhosis With or Without Renal Impairment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The investigators designed an observational multicenter explorative in vivo study to investigate the changes in ceftriaxone pharmacokinetics in blood and ascites. The investigators will include a total of 20 patients with liver cirrhosis admitted to the ward of participating hospitals. Patients are eligible when receiving ceftriaxone and concomitantly receive paracentesis. The investigators will collect all available waste blood samples of each participant, … |
MARTEN A LANTINGA; | 2023-07-10 |
| 299 | A Prospective Interventional Study Assessing The Clinical and Operational Effectiveness of Transitioning From Mircera to Daprodustat for The Treatment of Anemia in End Stage Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigator-initiated, interventional, prospective study to assess the clinical and operational effectiveness of daprodustat in adult patients receiving in center hemodialysis or peritoneal home dialysis who are transitioning from Mircera to daprodustat. |
GEOFFREY BLOCK; | 2023-07-01 |
| 300 | Correlation Between Endoscopic Findings And Helicobacter Pylori Infection In Chronic Kidney Disease Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to 1. Evaluate frequency of H. pylori infection in patients with CKD. 2. Description the gastroduodenal lesions found in patients with chronic kidney disease and correlate it to H.pylori infection. |
MOHAMED FAISAL ABDELLAH; | 2023-07-01 |
| 301 | Clinical Validation Study for Optimization of Anemia MAnagement in Hemodialysis Patients With End Stage Kidney Disease Using The Dialysis Anemia TReatmenT Model PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a human subject research study conducted in patients undergoing dialysis treatment with darbepoetin alfa at Intermountain Utah Dialysis and Intermountain Medical Center Dialysis Services. The purpose is to test a dose recommendation algorithm that may reduce hemoglobin variability and drug cost. |
CHEMITI GOPAL; | 2023-07-01 |
| 302 | Renal Resistive Index By Renal Doppler Ultrasound As A Predictor of Acute Kidney Injury and Evaluation of Fluid Administration in Sepsis Patients: Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: We aim from this study to investigate the role of renal resistance index (RRI) in evaluation of Acute kidney injury development and fluid administration in sepsis patients considering the change in RRI values over 7 days from admission as a predictor of AKI development |
SAFINAZ ABDELKHALEK ABOELFETOH; | 2023-07-01 |
| 303 | The Development and Validation of A Novel Equation for Estimating Sodium Intake in Peritoneal Dialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to develop a novel equation for estimating sodium intake in anuric peritoneal dialysis patients, and then to validate its precision and accuracy. |
DONG JIE; | 2023-07-01 |
| 304 | Evaluation of Renal Resistance Index By Doppler Ultrasonography in Patients Undergoing Arthroscopic Shoulder Surgery With Controlled Hypotension PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent studies, it has been reported that the renal resistive index is effective in detecting postoperative acute kidney injury in the early period. This study aims to evaluate the preoperative and postoperative renal resistive index variation with intraoperative controlled hypotension and research the renal resistive index’s utility in the early detection of renal dysfunction that may develop after surgery. |
FATMA ÖZKAN SIPAHIOĞLU; | 2023-07-01 |
| 305 | Short-term Safety and Efficacy of Ketohexokinase Inhibition in Patients With Hereditary Fructose Intolerance Related Papers Related Patents Related Grants Related Experts View Highlight: Hereditary fructose intolerance (HFI) is a rare inborn error of metabolism. Patients with HFI develop acute abdominal pain, nausea, vomiting, hypoglycemia and proximal tubular dysfunction upon consumption of a fructose containing food product. In rare cases, (prolonged) fructose consumption can even lead to liver and kidney failure. Patients with HFI are therefore treated with a lifelong fructose-restricted diet. Animal studies have shown that the clinical manifestations of HFI are abrogated upon inhibition of ketohexokinase (KHK), the enzyme that catalyses the first step in fructose metabolism. Recently, PF-06835919, a KHK inhibitor (KHKi), … |
PATRICK SCHRAUWEN; | 2023-06-15 |
| 306 | Longitudinal Assessment of Chronic Kidney Disease (CKD) Prevalence Rates and Risk Factors in A Primary Care Setting in Semirural Sub-Saharan Africa PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The RenalTWO study is a longitudinal investigation of chronic kidney disease (CKD) prevalence rates and its risk signature in a primary care walk-in population from semirural sub-Saharan Africa. The study is prospectively assessing CKD epidemiology according to current international guidelines, … |
MICHAEL MAYR; | 2023-06-01 |
| 307 | Pattern of Mucocutaneous Manifestations in Patients With Chronic Kidney Disease in New Vally and Assuit (Hospital Based Study) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: 1. To study the patterns of mucocutaneous disorders in Chronic Kidney Disease patients in Eldakhla General Hospital, New Valley and in Assiut University hospital . 2. Comparison of the patterns of mucocutaneous manifestations and their correlation with the different stages of Chronic Kidney Disease in renal unit of internal medicine of Eldakhla general hospital in New Vally and pediatric and adult renal units of Assuit university hospital . |
MARWA HASSAN MOHAMMED AHMED; | 2023-06-01 |
| 308 | Impact of Neutrophil Lymphocyte and Monocyte Lymphocyte Ratio on Chronic Kidney Disease Patients Outcome PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to establish NLR, MLR as a good predictors for outcome of CKD including hemodialysis and CKD stage (4-5) patients as regard inflammation, malnutrition and anemia on cardiovascular complication. |
ABDEL RAHMAN HASSAN MOHAMED; | 2023-06-01 |
| 309 | Identifying Barriers to and OptiMizing In-hosPitaL UsE of Evidenced-based Medical ThErapies for PatieNTs With Cardio-Renal-Metabolic Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be a prospective randomized implementation trial for patients hospitalized with heart failure, chronic kidney disease, and/or type 2 diabetes mellitus within Duke University Medical Center. The primary hypothesis is that a virtual quality improvement-based consult intervention will improve the rate of in-hospital evidence-based cardio-renal-metabolic medication use, particularly SGLT2 inhibitor therapy. Approximately 200 patients meeting eligibility criteria will be included in the study. Patients will be assigned into study groups, as defined by randomization of their treating clinician team to receiving the virtual consult versus not. |
STEPHEN J GREENE; | 2023-06-01 |
| 310 | Using Culturally-sensitive Discussions and Genetic Testing to Improve Access to Early Autosomal Dominant Polycystic Kidney Disease Care and Improve Health Disparities PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Individuals with a diagnosis of autosomal dominant polycystic kidney disease (ADPKD) often have a family history of the condition although up to 10-15% of cases are sporadic mutations. The investigators recently conducted an analysis of the investigators clinic population to determine percentages of individuals who have undergone kidney imaging and genetic testing and determined total numbers of patients eligible for tolvaptan and those currently active on tolvaptan. The study team found large racial discrepancies in usage of tolvaptan and found that more patients are eligible for tolvaptan than are currently taking the medication. Reasons for this are often due to patient perception about the medication rather than treatment failure. There is a strong medical need to understand reasons for underuse of this critical medication in this population. Among those with genetic testing, the study team found large disparities in ethnic background between individuals offered genetic testing who accept versus decline testing. The study team also found that those who choose to pursue genetic testing are more likely to have no family history of the condition, presumably because the diagnosis is more surprising to them and thus desire for verification by genetic testing, if possible, is greater. However, it is known that genetic testing can be an important component of understanding of disease biology in all patients with ADPKD, while also providing important clinical information in some cases as individuals prepare for living donor transplantation or family planning. The investigators seek to understand barriers to use of tolvaptan and genetic testing among individuals in the clinic population and their relatives across a wide range of racial and ethnic backgrounds. The investigators hypothesize that anxiety about genetic conditions in particular is a barrier to accepting testing. The investigators seek to understand the mental health aspects of the diagnosis of ADPKD. They will also evaluate changes in symptoms compared to pre-treatment after initiation of tolvaptan in eligible individuals using qualitative techniques. In so doing, the study team hope to improve care for current patients and also to expand the pool of the clinic population to include newly diagnosed family members ideally at early stages of disease. |
MEYEON PARK; | 2023-06-01 |
| 311 | Acute Effect of Photobiomodulation Therapy on Quadriceps Muscle Strength in Patients With Chronic Kidney Failure on Hemodialysis: A Crossover Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) consists of kidney damage and progressive and irreversible loss of kidney function. The aim of this study is to evaluate the acute effect of different doses of photobiomodulation therapy on quadriceps isometric muscle strength, pain and muscle fatigue of lower limbs and to establish the ideal dose for patients with CKD on hemodialysis. Patients will be submitted to application of photobiomodulation therapy in the quadriceps muscle. Immediately after, the maximum isometric strength test of the quadriceps will be performed. |
JOCIANE SCHARDONG; | 2023-06-01 |
| 312 | Analysis of T- and B-Cell Subpopulations in Patients With Primary Membranous Nephropathy PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this observational study is to provide analysis of T and B lymphocyte subgroups in peripheral blood samples of patients with primary membranous nephropathy (MN). A search for disease-related circulating antibodies \[anti-phospholipase A2 receptor antibody (anti-PLA2R) and anti-thrombospondin type 1 domain-containing 7A antibody (anti-THSD7A)\] in patients’ sera is also planned. The main questions to answer are: 1. What is the relationship of these cell populations and their distribution during follow-up with treatment, treatment responses, … |
SAFAK MIRIOGLU; | 2023-06-01 |
| 313 | Low-Carbohydrate Dietary and Lifestyle Interventions for The Management of Long COVID-19 Syndrome: A Prospective and Interventional Randomized Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Rationale: Hyper-inflammatory responses seen in acute COVID-19 are also a feature of long covid, a condition of long-term consequences that are persisting or appearing after initial infection and recovery from acute COVID-19. Long-standing, often disabling symptoms are common in long covid and can be highly varied. Common symptoms include fatigue, brain fog, muscle and chest pain, migraines, shortness of breath, anosmia, muscle weakness, and cognitive dysfunction. 35% of post-COVID patients were found to have decreased kidney function at 6 months post-discharge. In this study, … |
NURIA M. PASTOR-SOLER; | 2023-06-01 |
| 314 | The Effects of Passive Heat Therapy in Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this proposal is to investigate the acute effects of whole-body passive heat therapy using far-infrared technology on vascular function, exercise capacity, and renal function in CKD patients. The central hypothesis is that an acute bout of whole-body passive heat therapy will be well-tolerated and lead to acute improvements in large blood vessel (macrovascular) function, small blood vessel (microvascular) function, and exercise capacity without significantly altering markers of acute kidney injury. |
DANIELLE KIRKMAN; | 2023-06-01 |
| 315 | Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To study prevalence, risk factors, possible etiologies, clinical presentation and outcome of nephrocalcinosis in children at Sohag University Hospital. |
MENA SAAD MOHAMED; | 2023-06-01 |
| 316 | Natural History of Chronic Kidney Disease in The US Population Using Electronic Healthcare Records PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study in which the health data of people with chronic kidney disease are studied using electronic healthcare records. In observational studies, only observations are made without participants receiving any advice or any changes to healthcare. Chronic kidney disease (CKD) is a condition in which the kidney’s ability to work properly gradually decreases over time. This causes a buildup of waste in the body and can lead to loss of kidney function over the long term. CKD is divided into different stages based on how well the kidneys are filtering the blood. CKD is known to increase the risk of developing serious health problems such as serious heart problems, irreversible damage to kidneys requiring either dialysis or a kidney transplant (end stage kidney disease, ESKD), and early death. However, there is limited information available about how often heart problems occur in people with different stages of CKD, and how a history of heart problems might affect future risks for CKD patients. The purpose of this study is to collect more information on how CKD changes over time for people at different CKD stages and how it affects their heart and kidneys. The main information that researchers will collect in this study: changes in kidney function (worsening or improvement). Other information that researchers will collect: patient characteristics for each stage of CKD, the length of time for serious heart-related conditions to occur, the length of time it takes for CKD to progress to kidney failure, the length of time for occurrence of deaths due to any causes, and the length of time it takes for serious heart-related conditions and kidney failure to occur. This study will include CKD patients above 18 years of age. Researchers will review electronic healthcare records to identify CKD patients in two ways: using disease codes for CKD and using lab results which show abnormal kidney function. The data will come from participants’ information stored in an electronic healthcare records database called Merative Explorys database Electronic Medical Record (EMR) in the United States of America. The research will cover the period from January 2010 up to December 2019. Researchers will track individual patients’ data and will follow them for a maximum of 5 years or until they experience certain events like changes to their CKD stage, kidney failure, serious heart-related conditions, or death. In this study, only available data from routine care is analyzed. No visits or tests are required. |
BAYER | 2023-05-31 |
| 317 | Preference of Life-Sustaining Treatment Among Patients With End Stage Renal Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Although patients with kidney disease can rely on dialysis to prolong their lives, the complexity of the disease, the variability of the course of the disease, and the uncertainty of the prognosis often delay the discussion of issues at the end of life, and the deterioration of the condition often makes it impossible for the patient to express clearly or rationally. Treatment thoughts or preferences. Sufficient time is needed to think and discuss issues related to life treatment. Discuss with patients as soon as possible to help draw up end-of-life care plans, help patients realize end-of-life care preferences, … |
CHAN-SHIUAN KUO; | 2023-05-31 |
| 318 | Changes of Cognitive Function and Brain Magnetic Resonance in Maintenance Hemodialysis Patients With Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In recent years, due to the frequent occurrence of kidney disease and diabetes, the number of patients entering maintenance hemodialysis is increasing. With the economic development and dialysis quality improving year by year, the survival time of uremic patients is significantly prolonged, and the hazards of various complications are increasingly prominent. Cognitive impairment is a common complication of maintenance hemodialysis patients, … |
WENHU LIU; | 2023-05-30 |
| 319 | Neutrophil/Lymphocyte Ratio in Predicting The Severity of Acute Pancreatitis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute pancreatitis (AP) is a disease characterized by dysfunction of pancreatic acinar cells, improper activation of trypsin, and subsequent destruction of pancreatic self-defense mechanisms, further exacerbating injury and damage of pancreatic cells. It is a rapidly developing inflammatory process of the pancreas, and the most common reasons are alcohol and gallstones. |
ROMANY WAHEED MORKIS BESHAY; | 2023-05-30 |
| 320 | Assessing Combination Hydroxyurea and Exogenous Erythropoietin in Sickle Cell Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The proposed study is a Phase 1/2 multi-center study evaluating the safety and efficacy of erythropoietin (EPO) in combination with hydroxyurea in the treatment of chronic anemia in patients with sickle cell disease (SCD). |
JULIA XU; | 2023-05-25 |
| 321 | Effect of Low Doses of Hypoxia-inducible Factor- Prolyl Hydroxylase Enzyme Inhibitor Plus Iron in The Treatment of Anemia in Dialysis-dependent Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: this study aims to : 1. To compare the efficacy of combining low doses of Roxadustat Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase (PHD) inhibitor and iron versus standard treatment with erythropoietin-stimulating agents (ESA) in the treatment of anemia as a complication of chronic kidney disease (CKD) among dialysis-dependent patients. 2. To emphasize the safety profile of low doses of Roxadustat HIF-PHD. 3. To assess changes in the quality of life of patients with kidney disease before and after treatment. |
AHMED I ELMALLAH; | 2023-05-24 |
| 322 | A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study Evaluating The Efficacy and Safety of Dose-Titrated PLS240 in The Treatment of Secondary Hyperparathyroidism in Individuals With End Stage Kidney Disease on Hemodialysis (PATH-2) With An Open-Label Extension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to evaluate the efficacy and safety of PLS240 in patients with hemodialysis-dependent end stage kidney disease (ESKD) and secondary hyperparathyroidism (SHPT). The study consists of two phases. First, a placebo-controlled, double-blind phase where patients will be randomly assigned to either receive dose-titrated PLS240 or matching placebo for 27 weeks. After the completion of the double-blind phase, patients will be eligible to enroll in the open-label extension phase, where they will receive dose-titrated PLS240 for an additional 26 weeks. Throughout the duration of the study, … |
PATHALYS PHARMA | 2023-05-15 |
| 323 | Dapagliflozin in Non Alcoholic Fatty Liver Disease Associated Cirrhosis and Its Role in Preventing Development of Chronic Kidney Disease. A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The role of Dapagliflozin in the improvement in CKD in both diabetic and non-diabetic patients has been evaluated in the past. SGLT2i have also been found to be beneficial in NAFLD patients in improving the liver function parameters. It is also known that cirrhotic patients are at a higher risk of developing CKD at 1 year when compared to non cirrhotics. With this study we aim to study the role Dapagliflozin in cirrhotic patients in reducing the development of CKD, its impact on cirrhotic cardiomyopathy and its role in improvement of metabolic profile and liver related outcomes. |
INSTITUTE OF LIVER AND BILIARY SCIENCES INDIA | 2023-05-15 |
| 324 | Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine into a skinfold or a pen-injector to inject the study medicine into flat skin. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have to use a study app on their phone to record and share information about all their injections of study medicine and to fill in questionnaires. |
NOVO NORDISK | 2023-05-08 |
| 325 | Natriuretic-ureothelic Adaptation of Body Fluid Homeostasis During SGLT-2 Inhibition And/or Mineralocorticoid Receptor Modulation in Patients With Chronic Kidney Disease. A 4-arm, Double-blind, Double-dummy, Parallel-group, Phase 2 Study to Investigate The Mechanistic Effects of Dapagliflozin, Dapagliflozin + Balcinrenone, Balcinrenone and Placebo on Body Solute and Water Homeostasis and Energy Metabolism in Male and Female Participants Over 50 Years of Age With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to investigate the mechanistic effects of dapagliflozin 10 mg, alone or in combination with balcinrenone 150 mg, with balcinrenone 150 mg and placebo, on the way the body handles electrolytes and water content, as well as the effects these interventions may have on energy metabolism in participants with stage 3 chronic kidney disease. The study interventions will be administered orally, daily, in addition to current therapy, … |
ADRIANA MARTON; | 2023-05-08 |
| 326 | Multicentre Prospective Open Label Clinical Study to Evaluate The Effect of Personalized Therapy on Patients With Immunoglobulin A Nephropathy PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Idiopathic immunoglobulin A nephropathy (IgAN) is the most common biopsy-proven glomerulonephritis in the world. Approximately 40% of IgAN patients reach end-stage kidney disease (ESKD) 20 years after their kidney biopsy. The high prevalence of ESKD suggests the need to move from a generalized therapy for all patients to personalized therapy. Many RCTs have been conducted stratifying patients based on the laboratory findings (serum creatinine, eGFR and daily proteinuria). In contrast, data from the kidney biopsy has been used only for clinical diagnosis. Therefore, … |
FRANCESCO PAOLO SCHENA; | 2023-05-01 |
| 327 | Treatment Effects of Traditional Chinese Medicine (Gu Shen Juan Yu Formula) in Children With Inherited Proteinuric Kidney Disease：a Multicenter, Open-label, Two-arm, Parallel-design, Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether traditional Chinese medicine, Gu Shen Juan Yu Formula, as complementary treatment is safe and effective in the treatment of Inherited Proteinuric Kidney Disease. |
CHILDREN’S HOSPITAL OF FUDAN UNIVERSITY | 2023-05-01 |
| 328 | The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes mellitus people have a higher incidence of cardiovascular disease, and the results of cardiovascular events are worse. Heart failure and diabetes both have a worse prognosis, with a 1.5-2 times increased risk of death. Data from the literature have shown that MET lowers mortality by 14-35% in this patient population, which represents one-third of all HF patients with no increases in lactic acidosis incidence. |
SARA ELADAWY; | 2023-05-01 |
| 329 | The Effect of Vitamin D3 Supplementation on Hepcidin and Ferritin Serum Levels in Children With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to analyze the effects of in vitamin D3 on serum hepcidin and ferritin levels among children with chronic kidney disease. The main questions it aims to answer is: What is the effect of giving vitamin D3 on serum hepcidin and ferritin levels in children with chronic kidney disease? We will compare the effect of vitamin D3 administration on hepcidin and ferritin between 2 groups. Group A consists of children with GFR more 90 mL/min/1,73 m2. Group B consists of children with GFR less than 90 mL/min/1,73 m2 Participants will be given the same 2000 IU of Vitamin D/day for 6 weeks. |
ANDI MULDIANA DWI RACHMAYANI; | 2023-05-01 |
| 330 | A Multicentered, Single-group Phase 2, Exploratory, Open-label Study to Investigate Safety and Effect of Sparsentan in Combination With SGLT2 Inhibition in The Treatment of Adult Participants With IgAN PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 28-week, open-label, multicenter, single-group Phase 2 exploratory study to determine the safety and effect of sparsentan in participants with IgAN who are at risk of disease progression to kidney failure despite being on both stable RAASi and SGLT2 inhibitor treatment for at least 12 weeks prior to study entry |
TRAVERE THERAPEUTICS | 2023-05-01 |
| 331 | Effect of Dietary Fiber on Anemia and Glomerular Filtration Rate in Non-dialysis Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The main objective of this study was to investigate the effect of dietary fiber on anemia and glomerular filtration rate in non-dialysis patients with chronic kidney disease. Participants will be randomly divided into a dietary fiber intervention group and a blank control group. The patients in the dietary fiber intervention group will have dietary fiber intake survey conducted by dietitians on the basis of basic treatment. Supplemented dietary fiber was given on the basis of daily diet, once a day, 1 piece each time, before meals, … |
ZUNSONG WANG; | 2023-04-30 |
| 332 | A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study Evaluating The Efficacy and Safety of Dose-Titrated PLS240 in The Treatment of Secondary Hyperparathyroidism in Individuals With End Stage Kidney Disease on Hemodialysis (PATH-1) With An Open-Label Extension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to evaluate the efficacy and safety of PLS240 in patients with hemodialysis-dependent end stage kidney disease (ESKD) and secondary hyperparathyroidism (SHPT). The study consists of two phases. First, a placebo-controlled, double-blind phase where patients will be randomly assigned to either receive dose-titrated PLS240 or matching placebo for 27 weeks. After the completion of the double-blind phase, patients will be eligible to enroll in the open-label extension phase, where they will receive dose-titrated PLS240 for an additional 26 weeks. Throughout the duration of the study, … |
PATHALYS PHARMA | 2023-04-28 |
| 333 | Multifrequency Renal MR Elastography in Evaluation of Chronic Kidney Diseases: Can Shear Stiffness Evaluate Renal Fibrosis in GFR-normal Patients? PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Kidney Disease (CKD) is a major public health issue, leading to high mortality and the necessity for renal replacement therapy. Kidney fibrosis, resulting from chronic damage to kidney tissue, significantly determines CKD outcomes. Kidney biopsy, the gold standard for assessing fibrosis, is invasive and limited in its ability to reflect the heterogeneous nature of fibrosis. Consequently, there is growing interest in noninvasive methods, particularly Magnetic Resonance Elastography (MRE). MRE, which evaluates tissue stiffness, has shown potential for assessing kidney fibrosis. This study aims to use multifrequency MRE to assess renal fibrosis, focusing particularly on the early stages of CKD, … |
YU SHI; | 2023-04-28 |
| 334 | Validity and Reliability of Persian Version of Low Physical Activity Questionnaire (LoPAQ) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to assess validity and reliability of Persian Version of Low Physical Activity Questionnaire. The main questions it mains to answer are: What is the level of physical activity in hemodialysis patients? Is Persian Version of Low Physical Activity Questionnaire, Valid to assess physical activity levels of dialysis patients? Is Persian Version of Low Physical Activity Questionnaire, reliable? Participants will answer 3 questionnaires and will do some functional tests. |
MOHAMMADALI TABIBI; | 2023-04-26 |
| 335 | To Evaluate The Clinical Efficacy of Probiotic in Patients with DKD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the efficacy of probiotics in the treatment of diabetic kidney disease, this study is designed to explore after consumption of probiotics lactobacillus reuteri ADR-1 and lactobacillus rhamnosus GM-020 composite strain powder sachets for 6 months, whether the improvement of blood sugar, kidney related indicators can further improve the course of diabetic kidney disease. The clinical trial predicted that probiotics can improve diabetic kidney disease by changing the intestinal flora by inhibiting harmful bacteria, reduction of systemic oxidative stress, balance carbohydrate and fat metabolism, further preventing the progress of diabetic kidney disease. |
YI-SUN YANG; | 2023-04-24 |
| 336 | A Prospective, Long-term Confirmatory Follow Up Trial in Highly Sensitized Patients Treated With Imlifidase or Standard of Care in The ConfIdeS (20-HMedIdeS-17) Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this follow-up study is to learn about long-term patient survival and graft function in highly sensitized patients who have received desensitization treatment with imlifidase or standard of care (SoC) in order to enable kidney transplantation in clinical study ConfIdeS (20-HMedIdeS-17, NCT04935177). |
DOUGLAS ANDERSON; | 2023-04-21 |
| 337 | Washed Microbiota Transplantation (WMT) for Chronic Kidney Disease (CKD): A Open Label, Multicenter Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Wahsed microbiota transplantation (WMT) is a novel and promising therapeutic method for Chronic Kidney Disease (CKD). This clinical trail aims to evaluate the efficacy and safety of WMT in the treatment of CKD. |
THE SECOND HOSPITAL OF NANJING MEDICAL UNIVERSITY | 2023-04-20 |
| 338 | Janus Kinase-STAT Inhibition to Reduce APOL1 Associated Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine if the drug, baricitinib, is safe and effective in reducing high levels of albumin in the urine (albuminuria) in African American/Blacks with APOL1- associated focal segmental glomerulosclerosis (FSGS) and non-diabetic APOL1-associated chronic kidney disease due to hypertension (HTN-CKD). |
OPEYEMI OLABISI; | 2023-04-20 |
| 339 | Clinical Efficacy and Safety of Tenofovir Disoproxil Fumarate and Entcavir in Treatment of Chronic Hepatitis B Patients in Upper Egypt PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic hepatitis B (CHB) is one of the major causes of chronic liver diseases worldwide. Around 296 million people were living with chronic hepatitis B infection, with 1.5 million new infections each year and more than 820 thousand people die because of hepatitis B virus (HBV) related complications |
REHAB ABDELRAOF MOHAMED; | 2023-04-15 |
| 340 | ARTEMIS: RAvulizumab to PRotect PaTients With Chronic Kidney DisEase (CKD) FroM Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and Subsequent Major Adverse Kidney Events (MAKE): A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent cardiac surgery with CPB. |
ALEXION PHARMACEUTICALS | 2023-04-06 |
| 341 | A Phase 1b Multicenter, Randomized, Double-Blind, Placebo-Controlled Ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DISC-0974 in Participants With Non-Dialysis Dependent Chronic Kidney Disease and Anemia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This Phase 1b study of DISC-0974 will assess the safety, tolerability, pharmacokinetics (PK) and Pharmacodynamics (PD) of DISC-0974 in adult participants with Non-Dialysis Dependent Chronic Kidney Disease and Anemia. |
BRUCE RANKIN; | 2023-04-04 |
| 342 | Achieving Understanding of The Natural History of Sickle Cell Trait (AUNT) PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT. |
JULIE KANTER; | 2023-04-01 |
| 343 | The Effect of Azilsartan in Patients With Diabetic Kidney Disease and Hypertension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypertension is the most common complication in patients with diabetes nephropathy. Strengthening blood pressure and blood sugar control is the basic treatment for patients with diabetes nephropathy. Angiotensin receptor blocker (ARB) and angiotensin-converting enzyme inhibitor (ACEI) are the first line drugs recommended in domestic and international guidelines for diabetes patients to control hypertension. As a new ARB drug, azilsartan has been found to have better antihypertensive effect than other ARB drugs. However, due to the limited sample size and study time, azilsartan has no significant advantage over other ARB drugs in terms of renal protection effect, … |
ZHIDA CHEN; | 2023-04-01 |
| 344 | A Randomized, Double Blind, Placebo Parallel Controlled, 2 Cohorts, Multicenter Phase II Study to Investigate The Safety and Efficacy of SC0062 Capsule in Patients With Chronic Kidney Disease With Albuminuria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II study to investigate the safety, preliminary efficacy and pharmacokinetics of SC0062 capsule in patients with chronic kidney disease (diabetic kidney disease and IgA nephropathy)with albuminuria compared to matching placebo. |
BIOCITY BIOPHARMACEUTICS | 2023-04-01 |
| 345 | Diuretic Tuner Clinical Decision Support Mobile Device Application for Diuretic Titration in Hypervolemic States PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing. Participants in this study will have an application loaded on to their mobile phone by the study team and be taught how to use it over a 2 hour visit. Participants will need to check their blood pressure and weight daily and enter this information into the mobile phone application every day. Participants will need to follow daily instructions in their medication dosing provided by the application. There will be periodic blood testing. This will happen at 2 weeks, 90 days, and up to 4 other times if necessary. At the end of the study there is a 2 hour study visit during which participants will answer a survey. The total length of the study is 90 days. |
KAMALANATHAN SAMBANDAM; | 2023-04-01 |
| 346 | A Single Arm, Open Label, Pilot Study to Evaluate The Safety and Efficacy of Once Daily 25mg Empagliflozin in Patients on Peritoneal Dialysis With Residual Kidney Function PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this study is to determine the safety and mechanisms of SGLT2 inhibition in individuals on peritoneal dialysis (PD) with residual kidney function (RKF). |
SUNITA KS SINGH; | 2023-04-01 |
| 347 | A Prospective, Single-arm Study to Evaluate The Feasibility of Automated Wearable Artificial Kidney Peritoneal Dialysis (AWAK PD) in Subjects With End-Stage Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this late feasibility clinical trial is to evaluate the safety and effectiveness of the Automated Wearable Artificial Kidney (AWAK) peritoneal dialysis (PD) device in subjects with end-stage kidney disease. The main questions it aims to answer are: – the success of AWAK PD therapies when used in a home-setting – the safety and effectiveness of the AWAK PD system Participants will: – be titrated to find a suitable AWAK PD prescription – be trained on how to use the AWAK PD system independently – use the AWAK PD system at home for at least 7 days |
MARJORIE FOO; | 2023-03-31 |
| 348 | Efficacy and Safety of Cholestyramine in The Management of Hyperphosphatemia in Adult Hemodialysis Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to evaluate the efficacy and safety of cholestyramine in the management of hyperphosphatemia in hemodialysis patients. Colestilan is a non-metallic phosphate binder that acts as an anion-exchange resin. Colestilan itself is not absorbed after oral administration, and it is able to bind dietary phosphate within the gastrointestinal tract and thus prevent absorption of the mineral. Initial, Phase II, … |
AHMED ESSAM ALY; | 2023-03-30 |
| 349 | Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to investigate and test the effect of an acid/base diet in chronic kidney disease (CKD) patients, CKD stage 4 and 5. The trial is guided by the hypothesis that an acid/base diet will reduce the degree of acidosis and simultaneously reduce the need for bicarbonate supplements. |
LISBET BRANDI; | 2023-03-27 |
| 350 | A Multinational Survey-based Study to Understand The Real-world Awareness and Perceptions of Systemic InFLAMmation and RolE of HsCRP As A Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Cardiologists PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this survey is to collect information for scientific research and to better understand the role of systemic inflammation in identification, treatment and management of patients with ASCVD and CKD. This study is a cross-sectional design conducted among cardiologists in United Kingdom, Italy, Germany, Brazil, Saudi Arabia, Japan, Australia, China, India and France, treating ASCVD and CKD patients. Study participants will be recruited to complete an approximately 20-minute self-administered online survey. Recruitment will be conducted through email and phone. Data is collected though online data collection using a programmed survey. |
NOVO NORDISK | 2023-03-24 |
| 351 | A Multicenter, Randomized, Double-blind, Active-controlled, Parallel, Dose-finding Phase 2 Clinical Study to Evaluate The Efficacy and Safety of SPH3127 Tablets in The Treatment of Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To preliminarily evaluate the efficacy and safety of the renin inhibitor (SPH3127 tablets) in reduction in proteinuria in patients with diabetic kidney disease with valsartan as the comparator, and determine the recommended dose. |
SHANGHAI PHARMACEUTICALS HOLDING | 2023-03-22 |
| 352 | Feasibility Testing A ShareD DEciSIon Making Intervention for People With Kidney FailuRE (DESIRE), Their Relatives, and The Health Professionals in Kidney Services: A Pilot Randomized Controlled Trial Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this research is to test the acceptability and feasibility of a shared decision making intervention and a patient decision aid to support patients with kidney failure, relatives, and health professionals in planning and deciding about end-of-life care together. |
LOUISE ENGELBRECHT BUUR; | 2023-03-20 |
| 353 | Investigating A Novel Molecular Imaging Technique, Fast Field-Cycling, for Kidney Health and Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this pilot study is to explore the utility of Fast Field-Cycling (FFC) imaging in monitoring kidney disease. The main questions it aims to answer are: – If FFC imaging can differentiate healthy kidney from kidney disease – If there is an association between FFC imaging and standard clinical tests Participants will provide one blood and on urine sample, and will have one FFC imaging scan. |
UNIVERSITY OF ABERDEEN | 2023-03-08 |
| 354 | Early Goal Nutrition Therapy Guided By Indirect Calorimetry and Nitrogen Balance Among Critically Ill Patients With Acute Kidney Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to investigate the effects of nutrition therapy guided by indirect calorimetry and nitrogen balance among critically ill patients with acute kidney injury. The main question it aims to answer whether nutrition therapy guided by indirect calorimetry and nitrogen balance could improve 28 days mortality among critically ill patients with acute kidney injury or not. type of study: clinical trial Participants will be provided enteral or parenteral nutrition after randomization(48-72 days after admissions) with total energy guided by indirect calorimetry measurements and total protein by nitrogen balance with maximum of 1.3 gram per kilogram per day for total of 14 days If there is a comparison group: Researchers will compare with the control groups (nutrition therapy provided by physician using clinical equation of choice or judgements to see if participants were provided with these interventions, their 28 days mortalities would be better |
WANKAWEE JEERANGSAPASUK; | 2023-03-07 |
| 355 | Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about and test the effect of an acid/base diet, in chronic kidney patients with CKD stage 4 and 5 in an interventional study with a historical control. Our hypothesize is that an acid/base diet will reduce the degree of acidosis and the need for oral bicarbonate supplements. |
UNIVERSITY OF COPENHAGEN | 2023-03-06 |
| 356 | Pregnancy-associated Progression of Chronic Kidney Disease: A Study Protocol for The Development and Validation of A Clinical Predictive Tool PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: To develop and validate a tool that estimates the degree of pregnancy-associated progression of renal disease in women with CKD and pregnancy outcomes in an international multicentre cohort study. |
KING’S COLLEGE LONDON | 2023-03-01 |
| 357 | Comparison Between The Efficacy of Sodium-Glucose Co-transporter 2 Inhibitor Therapy Versus Angiotensin-converting Enzyme Inhibitor in The Treatment of Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Diabetes is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease worldwide. Diabetic kidney disease (DKD) is a clinical diagnosis based upon the presence of reduced glomerular filtration rate (GFR) and/or increased urinary albumin excretion (UACR) in diabetes. The inhibition of the renin-angiotensin system (RAS) has been identified as the cornerstone in the management of DKD for decades. Recently, … |
OMAR TAREK ELFARARGI; | 2023-03-01 |
| 358 | Trial of Intradialytic Cycling As Kidney Exercise Rehabilitation for Cardiac Stunning in Hemodialysis (TICKERS-HD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine the effect of a 12-week cycling during hemodialysis program on hemodialysis-induced myocardial stunning in adult individuals receiving hemodialysis. |
CLARA BOHM; | 2023-03-01 |
| 359 | Oral Intradialytic Amino Acids Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis (OASIS) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will test and compare the efficacy of a single essential amino acid valine with a combination of essential amino acids (EAA) supplement on fatigue, frailty, and cognitive function in end-stage kidney disease (ESKD) patients undergoing hemodialysis (HD) treatment. |
SUBRATA DEBNATH; | 2023-03-01 |
| 360 | Single-center, Multiple-strength, Single-dose Phase I Clinical Trial to Evaluate The Effect of Polyglycan Superparamagnetic Ferric Oxide Injection on Cardiovascular Magnetic Resonance Imaging in Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Polysaccharide super paramagnetic ferric oxide injection is an iron supplement developed for patients with iron deficiency anemia. Due to its characteristics, it has the potential to be a contrast agent. The DJTCSCYHT-I-04 study is a single-center, multiple-strength and single-dose phase I clinical study on cardiovascular MRI in patients with chronic kidney disease, aiming to investigate the effects and safety of multi-strength, single-dose at different time points, and to provide reference for clinical diagnosis and MRI enhancement. |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2023-03-01 |
| 361 | Effect of Fecal Capsule on Chronic Kidney Disease (CKD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: By collecting blood, urine and stool samples before and after oral Enterobacteriaceae capsule (FMT) from CKD subjects, we investigated the role and related mechanisms of gut microecology in the development of CKD using a combination of metagenomic sequencing, metabolomic analysis and flow cytometry. |
YAFENG LI; | 2023-03-01 |
| 362 | Fibrinogen to Albumin Ratio (FAR) As A Risk Factor for Type 2 Diabetic Nephropathy(DN) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aimed to investigate the association of fibrinogen to albumin ratio (FAR) with DKD type 2 and to prove its possible role as a novel biomarker to predict and prevent DKD progression. |
ABDALLAH GAMAL ABD EL HAFEEZ; | 2023-03-01 |
| 363 | Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to find out if empagliflozin, a new diabetic medication that has been shown to be very effective in lowering the risk of heart failure, is safe and tolerated in dialysis patients. In the recent years, empagliflozin has become a major tool to prevent heart failure hospitalization and to reduce the risk for cardiovascular death in diabetic and non-diabetic patients. Although patients with severe chronic kidney disease and ESKD have very high risk of heart failure and cardiovascular death, … |
MONIQUE CHO; | 2023-02-28 |
| 364 | Perioperative Nitric OxiDE-conditioning, Produced By Plasma-chemical Synthesis Technology, For PrevEnt Acute KidNey Injury During CarDiac SurgEry in Patients With ChRonic Kidney Disease (DEFENDER-trial) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The protective nitric oxide (NO) effects are mediated by selective pulmonary vasodilation and improvement of arterial oxygenation in hypoxemic patients by reducing intrapulmonary shunting and improving ventilation-perfusion coordination. Inhaled NO has been used for years to treat acute respiratory failure and pulmonary hypertension in anesthesia and intensive care. The nephroprotective role of NO was studied in an experimental model of contrast-induced nephropathy. The primary aim of this prospective, double-blind, randomized, parallel-group, controlled trial is to test the hypothesis that perioperative conditioning of patients with NO at a dose of 80 ppm, obtained by plasma-chemical synthesis technology, … |
NIKOLAY KAMENSHCHIKOV; | 2023-02-25 |
| 365 | A Phase 2, Randomized, Open-Label, Active-Controlled, Multicenter Study to Evaluate The Safety and Serum Phosphorus Lowering Effect of AP-306 in Chronic Kidney Disease Patients Receiving Maintenance Hemodialysis With Hyperphosphatemia PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical trial is to learn about the following questions in the patients receiving maintenance hemodialysis with elevated blood phosphorus: – How much effect AP-306 has assessed by blood phosphorus lowering; – How safe and tolerable AP-306 is. Participants will receive either following treatments: – AP-306, and – Sevelamer carbonate. |
LI WANG; | 2023-02-20 |
| 366 | Design and Effectiveness of Different Physical Exercise-based Interventions About Health Indicators and Quality of Life in Patients With Chronic Kidney Disease in Hemodialysis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Evaluate the effectiveness of different modalities of physical exercise about clinical health indicators and quality of life of patients with chronic kidney disease undergoing hemodialysis. |
UNIVERSIDAD DEL ROSARIO | 2023-02-15 |
| 367 | Impact of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs) Compared to Basal Insulin Start on Metabolic Targets in Patients Living With Type 2 Diabetes and Chronic Kidney Disease (Impact GLP-1 CKD) PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overall objective of this study is to compare the effectiveness of adding a glucagon-like peptide-1 receptor agonist compared with adding basal insulin for patients with type 2 diabetes and chronic kidney disease, already treated with an sodium-glucose cotransporter-2 inhibitor and not currently reaching target glycemic control. All sociodemographic information and clinical variables will be retrieved from the LMC Diabetes Registry. |
ALEXANDER ABITBOL; | 2023-02-15 |
| 368 | Dietary Potassium Liberalization With Fruit and Vegetables Versus Potassium Restriction in People With Chronic Kidney Disease (DK-Lib CKD) Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The study will look at the impact of the potassium content in fruits and vegetables, on serum potassium concentrations in people with Chronic Kidney Disease (CKD) using a randomized crossover design. Participants will receive home delivery of fruit and vegetables with either higher or lower potassium content in a random order. Clinical chemistry markers from blood and urine samples, blood pressure, physical functioning and health related quality of life will be assessed throughout the duration of the trial. This study will also measure their physical functioning, … |
DYLAN MACKAY; | 2023-02-15 |
| 369 | Validation and Evaluation of A Newly Developed Mobile Diet App for Enhancing Dietary Adherence for Patients With Chronic Kidney Disease (CKD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: A 12-week, prospective, multicenter, open-label pilot randomized controlled trial (RCT) will be carried out to determine the feasibility, acceptability and potential clinical efficacy of a newly developed mobile diet app among CKD populations at different stages in Malaysia. Participants will be randomly assigned into either (i) intervention group (mobile diet app) or (ii) control group (dietary counseling using conventional pamphlet). |
JAZLINA BINTI SYAHRUL; | 2023-02-15 |
| 370 | A Pragmatic Approach to Chronic Kidney Disease Patient Education in The Delta PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Over 350,000 adult Arkansans have chronic kidney disease (CKD) and 9 out of 10 (312,000) of these Arkansans are unaware of having it. A Know Your Kidney Number (eGFR) poster (KYKN) campaign is being launched statewide to increase CKD awareness and detection. As awareness increases, … |
MANISHA SINGH; | 2023-02-13 |
| 371 | A Prospective, Interventional, Multicenter, Phase IV, Open-label, Single Arm Study to Assess The Safety and Effectiveness of Finerenone in Participants From India With Chronic Kidney Disease Associated With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Researchers are looking for a better way to treat people with chronic kidney disease (CKD), a progressive decrease in the kidneys’ ability to work properly, and type 2 diabetes (T2D). In people with T2D, the body does not make enough of a hormone called insulin or does not use the insulin well enough. Insulin’s role is to regulate the amount of glucose (sugar) in the blood. Too much blood sugar can cause damage to the kidneys over time. Consequently, CKD can happen as one of the complications of T2D. The study treatment finerenone works by blocking a group of proteins, … |
BAYER | 2023-02-08 |
| 372 | Tirzepatide Study of Renal Function in People With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes: Focus on Kidney Hypoxia in Relation to Fatty Kidney Disease Using Multiparametric Magnetic Resonance Imaging PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: We are doing this study to learn more about how tirzepatide may help fight chronic kidney disease in people with obesity with or without type 2 diabetes (T2D). The study will last about 56 weeks and include up to 12 visits. |
CHRISTOPHER CHOW; | 2023-02-08 |
| 373 | A Single-Dose Study to Assess The Safety, Pharmacokinetics and Pharmacodynamics of Subcutaneous MK-2060 in Participants With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single subcutaneous dose of MK-2060 in stage 4 chronic kidney disease (CKD4) participants. The primary hypothesis is that the true geometric mean of the area under the concentration-time curve from 0 to infinity (AUC0-inf) after a single-dose of MK-2060 in adult CKD4 participants is at least 1130 nM*hr. |
MERCK SHARP & DOHME | 2023-02-08 |
| 374 | Dapagliflozin in The Prevention of Post-Coronary Intervention Acute Kidney Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To compare the incidence of acute kidney injury (AKI) post percutaneous coronary intervention (PCI) in a Dapagliflozin treated group versus a group managed with the usual standard of care. |
GREGG PRESSMAN; | 2023-02-01 |
| 375 | The Efficacy and Safety of Chinese Domestic Surgical Robot System in Urological Telesurgery, An Exploratory Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A single-arm clinical trial was designed in this study. The surgeon will perform urological telesurgery for patients using Chinese domestically produced MicroHand S surgical robot system. The MicroHand S surgical robot system consists of two physically separated subsystems named the surgeon console and the patient side cart. The surgeon console includes a stereo image viewer, two master manipulators, a control panel and several foot pedals. The patient side cart includes a passive arm that can slide in the up-down direction and be adjusted forward and backward, a swivel head that can rotate around the vertical axis, … |
HAITAO NIU; | 2023-02-01 |
| 376 | The Impact of Medication Reconciliation on Discrepancies and All-cause Readmission Among Hospitalized Patients with Chronic Kidney Disease: A Quasi-experimental Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aimed to evaluate the impact of combining medication reconciliation with medication review on reducing medication discrepancies at discharge and all-cause readmissions among CKD patients, in comparison to a retrospective control group that received usual care, which may or may not have included medication reconciliation. |
JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY | 2023-02-01 |
| 377 | Study of The Safety and Efficacy of Roxadustat in The Treatment of Heart Failure With Chronic Kidney Disease and Anemia PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to conduct a a cohort study to evaluate the efficacy and safety of the efficacy and safety of roxadustat for the treatment of anemia, quality of life and cardiac function in patients with heart failure and chronic kidney disease. |
JINGYI REN; | 2023-02-01 |
| 378 | Association of Diuretics With Change in Extracellular Volume, Natriuretic Peptides, Symptoms, and Cardiovascular Outcomes in CKD PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes. People with CKD have a high risk of cardiovascular (CV) diseases, such as heart attacks, heart failure, and strokes. Extra fluid in the body, called volume overload, may lead to CV disease in people with CKD. It is unknown if volume overload develops in the earliest stages of CKD, when treating it with common, … |
LUCILE P GREGG; | 2023-02-01 |
| 379 | Effect of Strength and Conditioning Training on Functional Performance in Children With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Despite the benefits of physical rehabilitation among adults and children with chronic illness, they avoid to engage in different physical activities especially pediatric population. Most of the children with Chronic kidney disease receive their medical treatment and follow-up with no change of their functional performance. We still lack the evidence of plyometric exercises in pediatric population with Chronic kidney disease . Therefore, the primary aim of this study is to explore the effects of strength and conditioning training in the form of plyometric exercises on balance and muscle strength in children with Chronic kidney disease . |
AMIRA MAHMOUD ABD-ELMONEM; | 2023-02-01 |
| 380 | The Effect of Dcr3 Levels in Blood and Urine on Renal and Patient Prognosis in Patients With Acute Kidney Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Kidney diseases represent a global public health problem due to the aging of the population, the increasing prevalence of diabetes, hypertension, obesity and immune disorders. TNF-superfamily ligands are heterotrimeric transmembrane proteins with a molecular structure characterized by the presence of a TNF homology domain that binds to cysteine-rich regions of specific TNF-superfamily receptors. The tumor necrosis factor (TNF) superfamily consists of ligands and receptors that modulate adaptive immunity regulation, hematopoiesis, morphogenesis, as well as different disease states, … |
BETUL DENIZ GOZMEN; | 2023-02-01 |
| 381 | Obesity Treatment to Improve Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As the obesity pandemic continues unabated, one can expect to see an increase in the prevalence of TID/T2D and associated CKD. As a result, death will rise, preceded by an increase in kidney failure, requiring dialysis and renal transplantation. Innovative medical treatment may help prevent chronic kidney disease (CKD) across our healthcare system. The guideline of the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) suggest that patients with obesity, TID/ T2D, and CKD needed either glucagon-like peptide 1 receptor analogs (GLP1-RA) or sodium-glucose cotransport-2 inhibitors (SGLT2i). If neither achieve metabolic control, … |
EBAA AL OZAIRI; | 2023-02-01 |
| 382 | Comparative Clinical Study to Evaluate The Efficacy and Safety of Oral Liposomal Iron, Oral Iron Supported Lactoferrin and IV Iron Dextran in Children With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a randomized, parallel study that will be conducted on pediatric patients with CKD. |
MAI SALAH EL-DIN; | 2023-02-01 |
| 383 | Evaluation of The Oxidative Status of Patients Undergoing Solid Organs Transplantation: Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective of this observational clinical study is to evaluate the variations in ascorbic acid during the transplantation phases and how these variations influence the oxidative status and patient outcome. The main questions it aims to answer are: – how many patients arrive at the transplant in a state of hypovitaminosis C? – how does hypovitaminosis C affect the patient’s oxidative status? – how does hypovitaminosis C affect the length of stay in intensive care and post-transplant complications? |
GIACOMO GRASSELLI; | 2023-02-01 |
| 384 | Empagliflozin in ESKD – A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to learn about the safety of empagliflozin in dialysis patients as a preparation for a future large clinical trial. Empagliflozin has been approved by the Food and Drug Administration for the treatment of either type 2 diabetes, heart failure, or chronic kidney disease among patients not on dialysis. The use of empagliflozin has not been studied or approved among patients on dialysis for kidney failure because empagliflozin acts on the kidneys. However, recent experimental studies have indicated that empagliflozin may provide direct heart benefits. Some dialysis patients have substantial residual kidney function, … |
YOSHITSUGU OBI; | 2023-02-01 |
| 385 | The Effect of Low Salt Diet on CKD Progression:A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Whether an intensive short-term dietary sodium restricted intervention will have beneficial effects on the glomerular filtration rate (GFR) and on the susceptibility to develop proteinuria, both measures of kidney function will be the objective of this study |
THANANDA TRAKARNVANICH; | 2023-01-31 |
| 386 | Effect of Huaier Granule on Nephrotoxicity Associated With Anti-angiogenesis Targeted Therapy for Advanced Hepatocellular Carcinoma: A Single-arm, Single-center, Exploratory Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, single-arm, single-center, exploratory study. The purpose of this study is to explore the effect of Huaier Granule on nephrotoxicity associated with anti-angiogenesis targeted therapy for advanced hepatocellular carcinoma. |
LU WANG; | 2023-01-31 |
| 387 | A Multicenter, NI, Retrospective, Observational Study Evaluating Real-World Treatment Outcomes in Japanese Patients With Metastatic Renal Cell Carcinoma (mRCC) Treated With Avelumab Plus Axitinib As First-line Therapy: J-DART2 PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is a multicenter, non-interventional, retrospective, medical chart review of participants with metastatic renal cell cancer(mRCC) treated with avelumab plus axitinib as a first-line therapy in Japan between 20 December 2019 and 17 October 2022. All decisions regarding clinical management and treatment of the participating patients were made by the investigator as part of standard care in real-world clinical setting and were not contingent upon the patient’s participation in the study. Data will be collected if available per study site. |
MERCK HEALTHCARE KGAA DARMSTADT GERMANY AN AFFILIATE OF MERCK KGAA DARMSTADT GERMANY | 2023-01-25 |
| 388 | Real Clinical Practice Register of AlbUminuRia Detection in Patients With Previously UndiAgnosed Chronic Kidney Disease PF:8 Related Papers Related Patents Related Grants Related Experts View Abstract: This register was sponsored and organized by the Association Eurasian Association of Internal Medicine. It is a multicenter non-interventional register of real clinical … |
EURASIAN ASSOCIATION OF THERAPISTS | 2023-01-20 |
| 389 | Efficacy of Fluid Distribution Timetable on The Treatment Adherence of End-Stage Renal Disease Patient: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Nonadherence to fluid restriction is a significant issue among hemodialysis patients globally, with numerous adverse health outcomes. These outcomes include increased intradialytic weight gain, acid-base and electrolyte imbalances, and decreased mental health. This study aimed to determine the effects of a fluid distribution timetable on adherence to fluid restriction among patients with end-stage renal disease undergoing hemodialysis. The study utilized a single-blind, … |
JOSHUA NATHANIEL ELLANO; | 2023-01-18 |
| 390 | Influences of High Versus Low-intensity Exercises in Post-COVID-19 Patients With Sarcopenia Secondary to Chronic Kidney Disease: Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: this study aims to compare the effect of high-intensity resistance exercises measured using the 10-repetition maximum versus low-intensity aerobic exercises on muscle performance, physical function and quality of life in chronic kidney patients with sarcopenia who recently recovered from COVID-19 infection |
HISHAM MOHAMED HUSSEIN; | 2023-01-15 |
| 391 | The Pharmacokinetics of Oral Tetrahydrocannabinol and Cannabidiol Across The Spectrum of Glomerular Filtration Rate: A PharmacoKinetic Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: POT-GFR-PK is a single dose pharmacokinetic study oral tetrahydrocannabinol (THC) and cannabidiol (CBD) in healthy adult controls and individuals with chronic kidney disease including those treated with in-center hemodialysis. |
MICHAEL WALSH; | 2023-01-11 |
| 392 | To Compare Relaxed Rotational Thromboelastometry Cut-offs With Standard Cut-offs for Guiding Blood Product Use Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure Patients: A Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Hypothesis Relaxed ROTEM cutoff guided blood product transfusion will result in less blood products use without increasing bleeding complications for invasive procedures in cirrhosis or acute on chronic liver failure (ACLF) patients AIM:- To evaluate the efficacy and safety of Relaxed threshold (as compared to conventional thresholds) for blood product transfusion for invasive procedures in cirrhosis or acute on chronic liver failure (ACLF) patients Objective – … |
INSTITUTE OF LIVER AND BILIARY SCIENCES INDIA | 2023-01-10 |
| 393 | Efficacy of Nitric Oxide Administration During Cardiopulmonary Bypass in Neonates at Reducing The Risk of Acute Kidney Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality. Despite effort, to date, no successful therapeutic agent has gained widespread success in preventing this postoperative decline in renal function. Nitric oxide is an intricate regulator of acute inflammation and coagulation and is a potent vasodilator. The investigators hypothesize that nitric oxide, administered during cardiopulmonary bypass (CPB), may reduce the incidence of AKI. |
CHILDREN’S HOSPITAL MEDICAL CENTER CINCINNATI | 2023-01-10 |
| 394 | Prevalence of Chronic Kidney Disease in Tunisian Diabetics PF:7 Related Papers Related Patents Related Grants Related Experts View Highlight: In Tunisia, diabetes is a serious public health problem, its prevalence reaches 22.9% of people aged 18 and over and is likely to affect a quarter of the population by 2045. Diabetic kidney disease is the most common and severe complication of diabetes. It is both a major cause of end-stage renal disease and a risk factor for mortality and cardiovascular morbidity, thus becoming an additional public health concern. Early diagnosis of diabetic kidney disease makes it possible to manage patients more effectively and in a multidisciplinary way, to delay its progression to chronic renal failure. |
AMEL HARZALLAH; | 2023-01-09 |
| 395 | Validity and Reliability of The Turkish Version of The Ottawa Sitting Scale in Hemodialysis Patients With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: Prolonged sitting behavior, characterized by minimal energy expenditure, poses significant health risks, especially for chronic kidney disease (CKD) patients undergoing hemodialysis. This sedentary behavior can lead to various health complications and a reduced quality of life (QOL). Objectives: This study aims to evaluate the validity and reliability of the Turkish adaptation of the Ottawa Sitting Scale (OSS) in assessing sitting behavior among CKD patients. Methods: A total of 130 CKD patients undergoing hemodialysis participated in this cross-sectional study conducted in XXX province between January 2023 and September 2023. The OSS, along with the Physical Activity Scale (FAS), … |
MEHMET HANIFI KAYA; | 2023-01-07 |
| 396 | Effect of Intravenous Iron Repletion on Renal Function in Patients With Iron Deficiency and Acute Kidney Injury, Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This clinical trial aims to carry out research on the effect on hemoglobin and renal function of intravenous administration of iron dextran as a repletion strategy in patients with iron deficiency anemia and acute kidney injury, in which the patient may benefit from this drug as it is expected to correct anemia, ferropenia and renal function parameters, when compared with a control group (placebo), … |
JONATHAN SAMUEL CHAVEZ IÑIGUEZ; | 2023-01-06 |
| 397 | Sodium Assessment of The Cardiac Tissue in Chronic Kidney Disease Patients Using Sodium Magnetic Resonance Imaging PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) is prevalent worldwide and affects around 10% of people living in developed health economies. As the kidney loses its function in patients with CKD, the kidneys are unable to filter toxins out of the blood as efficiently as those of healthy individuals. Arguably, … |
CHRIS MCINTYRE; | 2023-01-03 |
| 398 | Effects of Increasing Mean Arterial Pressure on Renal Function in Patients with Shock and with Elevated Central Venous Pressure : A Pilot Study for The Individualization of Mean Arterial Pressure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure. |
PIERRE ASFAR; | 2023-01-02 |
| 399 | Preserving Kidney Function in Children With Chronic Kidney Disease (PRESERVE) PF:8 Related Papers Related Patents Related Grants Related Experts View Highlight: Pediatric chronic kidney disease (CKD) results from health conditions that reduce kidney function for >3 months. It can progress to end-stage kidney disease (ESKD), which requires dialysis or kidney transplant. In adults, … |
CHRISTOPHER FORREST; | 2023-01-01 |
| 400 | Identification of Preoperative Parameters to Predict Acute Kidney Injury Risk Following Vascular or Digestive Surgery PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The study aims to identify the preoperative parameters associated with the risk of postoperative acute kidney injury (in particular the parameters of the SPARK score) in patients of the Besançon University Hospital who have undergone digestive or vascular surgery. |
CÉCILE COURIVAUD; | 2023-01-01 |
| 401 | Re- Admission Rate Among Survived Patients With Acute Respiratory Failure in Mansoura University Respiratory ICU : One Year Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Readmission to the intensive care unit (ICU) results in increased consumption of medical resources and costs, and has been proposed as a marker for quality of care. ICU readmission rates have been estimated at 4 to 14% and different risk factors have been proposed by various studies Readmitted patients mostly carry poor prognosis compared to newly admitted ones, in addition to the bad psychological impact for both patient and his family |
TAMER AWAD; | 2023-01-01 |
| 402 | A Multi-center, Open-label, Randomized Trial of Hemodialysis Plus Hemoperfusion on Blood Β2-microglobulin (β2-MG), Parathyroid Hormone (PTH) and C Reactive Protein (CRP) Clearance in Maintenance Hemodialysis Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This multi-center, open-label, randomized, parallel controlled trial aims to investigate the efficacy of hemoperfusion (HP) in combination with hemodialysis (HD) by assessing blood β2-microglobulin (β2-MG), parathyroid hormone (PTH) and C reactive protein (CRP) clearance in maintenance hemodialysis patients. |
CHANGHAI HOSPITAL | 2023-01-01 |
| 403 | A Prospective Observational Study of Galectin-3 in Septic and Non-septic Acute Kidney Injury PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute kidney injury (AKI) is a common critical condition with high morbidity and mortality. The level of circulating Galectin-3 (Gal3) largely depends on renal function, so it is elevated in patients with AKI or CKD; elevated Gal3 also aggravates the progression of CKD after the onset of AKI. The proinflammatory and profibrotic properties of Gal3 may render it to be one of the key molecules mediating AKI, CKD, and cardiorenal syndrome. In this prospective observational study, the investigators will explore the differences of Gal3 levels among septic AKI, non-septic AKI, and non-AKI patients and its correlation with prognosis, inflammation, … |
FENGYUN WANG; | 2023-01-01 |
| 404 | Potential Use of Dapaglifozin to Avoid Acute Kindey Injury (AKI) to Chronic Kidney Disease (CKD) Transition: DAKI-CKD Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Justification: Studies in recent years have shown that suffering an episode of acute kidney injury (AKI) is an independent risk factor for developing chronic kidney disease (CKD), which is associated with cardiovascular complications, increases medical care costs, and decreases survival. These AKI to ERC transition cases add to the growing number of CKD cases already being seen globally. It is for them that in recent years therapeutic strategies have been sought to reduce or stop this process of transition from AKI to CKD. Objective: To evaluate the efficacy and safety of the use of dapagliflozin plus standard medical treatment (TMS), … |
OLYNKA VEGA; | 2023-01-01 |
| 405 | A Phase 2, Multicenter, Open-label, Randomized, Active-Controlled Study of Efficacy and Safety of AND017 in The Treatment of Anemia in Patients With Chronic Kidney Disease on Dialysis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a phase II study to evaluate the safety and efficacy of AND017 in renal anemia patients on dialysis |
KIND PHARMACEUTICALS | 2023-01-01 |
| 406 | Transitioning Patients with Advanced Chronic Kidney Disease to Home or In-center Dialysis: Understanding The Experience and Quality of Life for Patients and Their Caregivers PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: For people with advanced kidney disease, deciding which type of dialysis is best can be challenging. Studies have shown that quality of life is very important to patients. It is thought that the quality of life of people receiving their dialysis at home may be better than the one of people receiving dialysis in a hospital. However, … |
ANNIE-CLAIRE NADEAU-FREDETTE; | 2023-01-01 |
| 407 | Prevalence of Acute Kidney Injury in Patients With Diabetic Ketoacidosis PF:3 Related Papers Related Patents Related Grants Related Experts View Abstract: Acute kidney injury (formerly known as acute renal failure) is a syndrome characterised by the rapid loss of the kidney’s excretory function and is typically diagnosed by the … |
AHMED REFAAT FATHY; | 2023-01-01 |
| 408 | Urinary Tract Infection in Patients With Chronic Kidney Disease: A Retrospective Observational Study at Outpatient Nephrology Clinics PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to investigate the etiology and associated risk factors for UTI in Egyptian chronic kidney disease patients. In addition, to identify the isolated micro-organisms and their sensitivity patterns for better anticipation of treatment regimen. |
MOHAMED MAMDOUH MAHMOUD MOHAMED ELSAYED; | 2023-01-01 |
| 409 | Cardiac Structure and Function in Patients with Cystic Fibrosis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these are prognostic markers of heart disease in patients suffering from cystic fibrosis (CF). |
TOR BIERING-SØRENSEN; | 2023-01-01 |
| 410 | A 24-Week, Open-Label, Randomized, 2-Arm Study to Evaluate The Safety and Tolerability of KRX-0502 (Ferric Citrate) in Children With Iron Deficiency Anemia Associated With Non-Dialysis Dependent Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will be conducted to evaluate the safety and tolerability of ferric citrate in pediatric participants with iron deficiency anemia (IDA) associated with non-dialysis dependent chronic kidney disease (NDD-CKD). |
KERYX BIOPHARMACEUTICALS | 2023-01-01 |
| 411 | A Randomized Controlled Trial to Evaluate The Efficacy of Plant-protein Diets in Patients With Chronic Kidney Disease: A Pilot-study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to evaluate the efficacy of plant-protein diets for 12 weeks in patients with advanced chronic kidney disease. |
YUSUKE SAKAGUCHI; | 2023-01-01 |
| 412 | Positive Psychological Intervention Delivered Using Virtual Reality in Hemodialysis Patients With Comorbid Depression: Randomized Controlled Trial Assessing Feasibility and Efficacy Testing PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The long-term goal is to create behavioral health technologies to advance the science that leverages state-of-the-art technology to delivery psychotherapeutic treatment to individuals on hemodialysis (HD) to improve their emotional well-being, quality of life, and overall health. The objective in this small R01 study is to design a virtual reality (VR) platform, that fully immerses users into a fictitious lifelike environment, to deliver an evidence-based positive psychological intervention and to test whether it improves the emotional well-being of individuals on HD with comorbid depression. In this proposed 2-arm randomized controlled trial, … |
ROSALBA HERNANDEZ; | 2023-01-01 |
| 413 | The Dynamic Change of Fecal Calprotectin From Day 1 to Day 3 Was Associated With Sepsis-associated Liver Dysfunction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: As defined by sepsis 3.0, sepsis is a clinical syndrome caused by disordered host response to serious infection，leading to multiple organ dysfunction1. Sepsis-associated liver dysfunction (SALD) is one of the most frequently complication in sepsis, possessing high morbidity and mortality2. A close relationship exists between the gut and the liver, … |
CHINESE MEDICAL ASSOCIATION | 2023-01-01 |
| 414 | Cell-based Therapy for The Treatment of Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Endothelial progenitor cells derived from and delivered to the renal vasculature may be stimulated to initiate differentiation programs during episodes of injury. It is hypothesized that endothelial progenitor cells from the kidney can transition to a phenotype that promotes endothelial repair. |
ANDREW MICHAEL SIEDLECKI; | 2023-01-01 |
| 415 | A Phase IIb, Multicenter, Open-Label, Prospective Study of Bremelanotide in Diabetic Kidney Disease to Assess The Efficacy in Reducing Urinary Protein and Maintaining Podocyte Density and Function PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a prospective, open-label trial to assess the efficacy of melanocortin receptor agonist bremelanotide (BMT) when administered with RAAS inhibition therapy after six months in subjects with Type II diabetic nephropathy. After six months of therapy, all subjects will remain in trial for further assessment and undergo a diagnostic renal biopsy to assess the effect of melanocortin therapy on diabetic histopathology at 12 months. |
JAMES TUMLIN; | 2022-12-29 |
| 416 | Neutrophils to Lymphocytes and Platelets Ratio (N/LP) As Predictor of Mortality in Septic- Acute Kidney Injury Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: To evaluate the role of Neutrophils to lymphocytes and platelets ratio (N/LP ratio) as a biomarkers for mortality in septic -AKI |
MAHMOUD KAMEL MOHAMED ABD ELHAQ; | 2022-12-25 |
| 417 | External Validation of The VExUS Score for The Prediction of Acute Renal Failure in Cardiac Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Acute renal failure is a frequent complication associated with significant morbidity and mortality in postoperative cardiac surgery. The VExUS (Venous Excess UltraSound grading system) score was created to qualitatively assess this venous congestion, based on ultrasound data from patients obtained post operatively in cardiac surgery. These data included: inferior vena cava diameter, Doppler flow of the suprahepatic veins, portal trunk and renal veins. This score is predictive of the onset of acute renal failure in the first 3 days after surgery. The VExUS score has not been validated in an external and prospective way in cardiac surgery. |
TIMOTHÉE ABAZIOU; | 2022-12-19 |
| 418 | An Open Label, Phase II Study to Investigate DSA Rebound in Patients With A Positive Crossmatch, Made Transplantable With Imlifidase Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess whether imlifidase in combination with bortezomib, belatacept, rituximab and IVIg can suppress donor specific antibodies (DSA) and the occurrence of antibody-mediated rejection (AMR) in highly sensitized patients with chronic kidney disease with a positive crossmatch towards their living donor during a period of 3 months from transplantation. |
HANSA BIOPHARMA AB | 2022-12-16 |
| 419 | Effectiveness and Safety of Finerenone in Chinese CKD Patients Without Diabetes Mellitus: A Real-world Retrospective Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background： This study aimed to evaluate the effectiveness and safety of Finerenone in patients with chronic kidney disease (CKD) without diabetes mellitus(DM), however, evidence based on both clinical trails and real-world data are limited. Methods: Patients with CKD without DM were enrolled in this study from December 2022 to December 2024. In conjunction with the established treatment regimen for chronic kidney disease (CKD), study participants were additionally administered Finerenone. To evaluate the therapeutic impact and safety profile of the intervention, three primary biomarkers were monitored: 24-hour urinary protein (UTP), estimated glomerular filtration rate (eGFR), … |
FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY | 2022-12-15 |
| 420 | Biorepository of Biospecimen Samples in Matched Healthy Control Participants and Participants Diagnosed With Diabetic Kidney Disease, Chronic Kidney Disease, or Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The Investigators will generate a repository of human biosamples across therapeutic areas that will be used to identify disease-associated biomarkers and potential targets with immune and multi-omics profiling. This sample collection and analysis from people living with type 2 diabetes, or chronic or diabetic kidney disease will lay the groundwork for an extensive network of biosample access and linked datasets that will provide an invaluable resource for translational research. |
SANGUINE BIOSCIENCES | 2022-12-15 |
| 421 | The Effect of Virtual Reality Application on Pain and Anxiety Level in Stone Crushing With Shock Waves: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This research was planned as a randomized controlled experimental study in order to evaluate the effect of virtual reality application on pain and anxiety caused by the procedure during stone crushing process (ESWL) with shock waves. |
MERAL YILDIRIM ÇETINKAYA; | 2022-12-15 |
| 422 | Comparison of Brachial Wrist Index Before and After Implantation of Arteriovenous Fistulas, Based on Brachial Artery in Surgical Candidates Referred to Surgical Clinics in Gorgan in 1400 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Arterio-Venous Fistula (AVF) is the most recommended vascular access for hemodialysis. Steal syndrome is a potential complication of AVF implantation and occurs secondary to diversion of the arterial flow of a limb to the venous system resulting in limb ischemia. Measuring wrist pressure compared to arm pressure before and after fistula implantation can be a suitable tool in predicting the possibility of Steal syndrome. In this study, the ratio of wrist to arm pressure and its relationship with Steal syndrome symptoms before and after fistula implantation are investigated. |
PEZHMAN KHARAZM; | 2022-12-11 |
| 423 | Therapeutic Evaluation of STeroids in IgA Nephropathy Global – Post-Trial ObservatioNal Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of this study is to extend follow up of TESTING study participants and to assess the long-term effects of a 6-9-month course of oral methylprednisolone on End Stage Kidney Disease (ESKD), according to dose (full-dose vs reduced-dose), ethnicity (Chinese vs other) and kidney function (eGFR above and below 60 mL/min/1.73m2). |
MUH GEOT WONG; | 2022-12-07 |
| 424 | Genetic of Chronic Kidney Disease and Gout : Analysis of Melanesian Families From New Caledonia PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this research is to study the associations of genetic variants of gout and kidney failure, which are very common in the Melanesian population in New Caledonia |
THOMAS BARDIN; | 2022-12-05 |
| 425 | Effects of Intradialytic Inspiratory Muscle Training at Different Intensities on Diaphragm Hypertrophy and Functional Capacity in Patients Undergoing Hemodialysis: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigate the effects of Inspiratory Muscle Training (IMT) performed during hemodialysis (HD) procedures in patients with end stage kidney disease (ESKD). With intervention of thirty-six IMT sessions, performed three times a week, at an intensity of 50%, 30% and 10% (sham) of the maximum inspiratory pressure (MIP). |
HOSPITAL DE CLINICAS DE PORTO ALEGRE | 2022-12-01 |
| 426 | EHealth Based Self-management Intervention for Chronic Kidney Disease Care in China PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to develop an evidence-based tailored eHealth self-management intervention for patients with chronic kidney disease in China, and test the impact on implementation and effectiveness of interventions. |
NIELS CHAVANNES; | 2022-12-01 |
| 427 | The Role of Endothelial Glycocalyx in Kidney Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is detailed examination of endothelial glycocalyx in kidney transplantation. Researchers will evaluate markers of degradation of EG in blood and urine; and also perform direct visualisation of EG with sidestream dark field imaging (SDF) in both donors and recipients of kidney transplantation. The aim is to summarize the current knowledge and to point out the importance of EG in kidney transplantation. |
PAVEL NAVRÁTIL; | 2022-12-01 |
| 428 | Finerenone on Top of SGLT2is: A CoMparatIve Hybrid Study Based ON RCT/RWE Data Of Patients With Chronic Kidney Disease Associated With Type 2 Diabetes PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study, in which data from the past of people with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied. The participants in this study were treated in the past with a type of drug called SGLT2 inhibitor alone or with SGLT2 inhibitors in combination with finerenone. In observational studies, only observations are made without specified advice or interventions. CKD is a long-term progressive decrease in the kidneys’ ability to work properly. In people with T2D, the body does not make enough of a hormone called insulin, or does not use insulin well enough, … |
BAYER | 2022-11-23 |
| 429 | Impact of The Characteristics of Acute Renal Failure in Intensive Care on The Long-term Renal Prognosis: Prospective Multicenter Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to assess the impact of Acute Kidney Injury (AKI) characteristics on long-term renal prognosis in Intensive Care Unit (ICU) patients. |
ALEXANDRE LAUTRETTE; | 2022-11-22 |
| 430 | A Randomized Controlled Clinical Trial of Cordyceps Militaris Beverage on The Immune Response PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This study developed functional beverages from the submerged fermentation of Cordyceps militaris (FCM) and aimed to investigate the potential of FCM in male and female healthy volunteers in Phayao province, Thailand. To provide essential information for the development of healthy drink products. |
ATCHARAPORN ONTAWONG; | 2022-11-22 |
| 431 | The Minuteful Kidney Test Evaluation: A Randomised Controlled Trial PF:10 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic Kidney Disease (CKD) is a long-term condition in which the ability of the kidneys to function gets worse over time. People with CKD often do not have associated symptoms, meaning that it is possible for the condition to go undetected until the condition worsens and symptoms develop. The disease is more common in people with diabetes and screening by means of urine and blood tests is recommended in this population by The National Institute for Health and Care Excellence (NICE) Guidelines in order to detect disease earlier. However, … |
UNIVERSITY OF LEICESTER | 2022-11-18 |
| 432 | Incidence and Clinical Burden of Erythropoietin Hyporesponsiveness – A Retrospective Database Analysis PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This study consists of two phases. The purpose of phase 1 is to identify incidence and patterns of erythropoiesis-stimulating agent (ESA) hyporesponsiveness and its associated factors in ESA treated patients. The purpose of phase 2 to identify outcomes associated with ESA hyporesponsiveness. Key aspects of the phase 2 study design will entirely depend on the results from phase 1. |
ASTELLAS PHARMA GLOBAL DEVELOPMENT | 2022-11-18 |
| 433 | Development, Feasibility Testing and Validation of A Survey Set to Measure Patient-Reported Outcomes Among Hemodialysis Patients in Turkey PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Development, feasibility testing and validation of a Survey Set to Measure Patient-Reported Outcomes among Hemodialysis Patients in Turkey: Creating and testing an electronic patient questionnaire that is suitable to measure health-related quality of life in Turkish dialysis patients in clinical as well as in home care settings. |
HAYRIYE ELBI; | 2022-11-18 |
| 434 | Study of The Prevalence of Iron Deficiency in Elderly Patient in Hospital Environment PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: Iron deficiency is defined by insufficient tissue iron stores and anemia is the ultimate stage of iron deficiency. Anemia should never be neglected in an elderly subject because it is associated with an increase in mortality, but also with a increased morbidity in terms of complications Apart from anemia, iron deficiency is common and constitutes a factor of poor prognosis in diseases chronic, all pathologies very frequently found in the elderly. It is the origin of the deterioration in the general condition of patients, … |
VIFOR PHARMA | 2022-11-15 |
| 435 | Combined General Anesthesia and Ultrasound Guided Supraclavicular Block Versus General Anesthesia in Pediatric Patients With Chronic Kidney Disease Undergoing Upper Limb Superficialization of Arteriovenous Fistula PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: – compare the safety and efficacy of ultrasound-guided supraclavicular block in addition to general anesthesia in pediatric patients undergoing upper limb superficialization of arteriovenous fistula for hemodialysis. – compare the amount of analgesic consumption as well as vasodilatation of upper limb blood vessels and its implications on the vascular anastomosis. |
ESRAA FATHY RADWAN ABD ELZAHER; | 2022-11-14 |
| 436 | Effect of Sodium-Glucose Co-transporter 2 Inhibitors on Kidney Disease Progression and Bone Mineral Metabolism in Non-diabetic Patients With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: It is a randomized controlled trial in which 100 non diabetic chronic kidney disease (CKD) patient is being participated. Their estimated glomerular filtration rate (eGFR) between 25-75 ml/min/1.73 m2. Participants will be randomized into two groups: – Study group: includes 50 patients, they will receive Sodium glucose co-transporter 2 inhibitor (SGLT2i) as add on drug, Dapagliflozin 10 mg will be used once daily with or without food. – Control group: includes 50 patients, … |
MOHAMED MOHSEN ELSHAYEB; | 2022-11-10 |
| 437 | An 18-month, Open-label, Single-arm Safety Extension Study of An Age-and Bodyweight-adjusted Oral Finerenone Regimen, in Addition to An ACEI or ARB, for The Treatment of Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, … |
BAYER | 2022-11-08 |
| 438 | Safety and Clinical and Virologic Outcomes in COVID-19 Patients With Chronic Kidney Disease Treated With Nirmatrelvir-ritonavir PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Nirmatrelvir-ritonavir is approved for coronavirus disease 2019 (COVID-19) but not initially recommended in patients with severe renal impairment. Increasing observational data have shown the feasibility of dose-adjusted nirmatrelvir-ritonavir administration in patients with estimated glomerular filtration rate lower than 30 ml/min/1.73 m^2. The study is planned to assess the safety, clinical and virologic outcomes of early oral nirmatrevir-ritonavir treatment of COVID-19 in patients with stage 4 and 5 chronic kidney disease. |
CHOW KAI MING; | 2022-11-07 |
| 439 | The Feasibility and Acceptability of A Multicultural Healthy Diet (Anti-inflammatory Dietary Pattern) in Racial/Ethnic Minorities With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a pilot intervention study to evaluate the feasibility and acceptability of a culturally-tailored anti-inflammatory diet intervention in participants with chronic kidney disease. |
TANYA JOHNS; | 2022-11-03 |
| 440 | A Game-based Foot & Ankle Exercise Program to Increase Efficacy Of Compression Garments At Managing Edema PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The present study aims to use a game-based tele-exercise program for patients using a compression garment to improve lower extremity edema. This tele-exercise gaming platform can work as an efficient exercise to improve patients’ muscle strength. It also can be helpful in improving edema and venous return and can be used in addition to compression garments to increase efficacy. The sample size (n=30) is convenient and designed to explore acceptability and feasibility. Eligible participants will be screened at the Baylor college of Medicine Clinic based on the inclusion/exclusion criteria. Participants who satisfy the inclusion and exclusion criteria and sign the informed consent form will be randomly assigned with ratio of 1:1 into two groups. Both groups will receive a compression garment to use for 4 weeks, and in the intervention group, patients will receive a sensor and a tablet to play foot & ankle exercise games twice a day for 5 minutes. Study participation will be 4 weeks for all participants. Participants will be assessed in two visits: a baseline visit (BL) and a visit at the end of the 4 weeks (W4). The primary outcomes will be calf circumference, foot volume, and pitting edema grade. Secondary outcomes include limb strength, foot perfusion, gait assessment (gait speed, stride length, double stance, and gait steadiness), balance, and quality of life. The coordinator will monitor patients weekly to see their adherence to the compression garment and game-based exercise. |
BIJAN NAJAFI; | 2022-11-03 |
| 441 | Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Patients treated with hemodialysis (HD) bear increased risk of cardiovascular events, which results in high morbidity and mortality among this cohort of patients. Intradialytic hypotension (IDH), which is an independent risk factor for mortality, occurs in up to 20% of hemodialysis session and may lead to myocardial stunning and cerebral ischemia resulting in increased white matter lesions, gastrointestinal ischemia and shunt vessel thrombosis. Due to the deleterious effects of IDH during HD, preventive measurements such as limiting interdialytic weight gain are recommended, but frequently fluid and salt restriction are not adhered to, … |
MEDICAL UNIVERSITY OF GRAZ | 2022-11-02 |
| 442 | Prediction of Outcomes in Patients With Chronic Heart Failure Based on Tissue Raman Spectroscopy PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic heart failure (CHF) is a syndrome complicating heart disease, the prevalence of which has reached epidemic levels. According to global statistics the most common causes of CHF are coronary heart disease (CHD): 26.5%, arterial hypertension (AH):26.2% . The category of patients with CHD complicated by CHF prevails in clinical practice, requiring an optimized approach to determining prognosis in order to improve the effectiveness of therapy. In the literature, this issue has been studied with the use of general clinical, biochemical, instrumental criteria. Nevertheless, … |
PETR A LEBEDEV; | 2022-11-01 |
| 443 | Effect of Implementing A Care Bundle on The Progression of Acute Kidney Injury in Critical Patients PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this clinical interventional study is to learn about the effect of implementing a care bundle in the progression of acute kidney injury (AKI) in critical patients. The main questions it aims to answer are: – What is the impact of care bundle in AKI progression? – Some improvement of care bundle adhesion rate through an electronic alert can be achieved? Participants will be adults and critical patients with AKI. During observational study the incidence and progression of AKI will be measured, as well spontaneous care bundle adhesion by medical team. In the interventional study, … |
LYGIA LUSSIM; | 2022-11-01 |
| 444 | Fluid Overload Management and Vascular Stiffness in Chronic Kidney Disease Patients With Hypertension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study aims to reduce fluid overload in order to control blood pressure of hypertensive CKD patients using bio-impedance assessment of fluid status and using a diuretic therapy algorithm. |
BRANKO BRAAM; | 2022-11-01 |
| 445 | Addressing Diffusion of Responsibility and Prescribing Burden to Improve Use of Diabetes Medications PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study will test the impact of addressing diffusion of responsibility with and without additional reduction of prescribing burden on SGLT-2i and GLP-1RAs prescribing compared to usual care. Population: MGH primary care physicians caring for at least 2 eligible patients. Eligible patients are individuals age18 years or older with type 2 diabetes and HbA1c >7.5% and a compelling indication for an SGLT-2i or GLP-1RA (including cardiovascular disease, kidney disease, heart failure, or obesity), who are not already prescribed one of these therapies. Intervention: PCPs will be randomized to one of three arms: 1) intervention to address diffusion of responsibility, … |
NANCY HAFF; | 2022-11-01 |
| 446 | Effect of An Extended Kidney Disease: Improving Global Outcomes (KDIGO) Bundle Versus Standard of Care Therapy on Persistent Acute Kidney Injury in High-risk Patients After Major Surgery PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury. To investigate whether an implementation of a supportive extended care bundle in high-risk patients for persistent acute kidney injury (AKI) can reduce the occurrence of persistent surgical AKI. In order to investigate whether the extended KDIGO bundle can prevent persistent AKI in patients with high chemokine ligand 14 (CCL14) as well as in patients with low CCL14, patients will be randomized with stratification by the CCL-value. |
UNIVERSITY HOSPITAL MUENSTER | 2022-11-01 |
| 447 | Belatacept As A Replacement for CNIs 3 to 12 Months Post-transplantation in Patients With Early Graft Dysfunction PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Calcineurin inhibitors (CNI) remain the standard treatment in renal transplantation to prevent rejection. Currently the main limitation of kidney transplantation is the occurrence of chronic graft dysfunction due to the CNI nephrotoxicity. Thus, strategies to minimize or stop CNI have been developed as belatacept, a fusion protein (CTLA4-Ig) blocking the ligand of the main CD28 costimulatory molecule. In the original phase III trial, used de novo in combination with MMF (without CNI) belatacept allowed to obtain a better renal function as soon as 1 year and a better graft and patient survival after 7 years. Despite these excellent results, … |
SIMON VILLE; | 2022-11-01 |
| 448 | Protein Supplementation and Exercise Training to Increase Muscle Protein Synthesis Rates in Patients With Advanced Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: When patients progress to the final stage of chronic kidney disease (CKD) and require hemodialysis treatment, they typically have lost so much muscle function that they are no longer physically independent. However, due to disease- and hemodialysis-related muscle catabolism, dietary protein and exercise interventions are only capable to attenuate the decline in physical function of patients on hemodialysis treatment. Therefore, lifestyle interventions to increase muscle function should be implemented before hemodialysis is required. However, … |
LUC JC VAN LOON; | 2022-11-01 |
| 449 | Comparison of Procalcitonin Level in Normal Population and in Chronic Kidney Disease Patients Who Don’t Have Infection PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Chronic kidney disease (CKD) is a life threatening condition with high risk of pre-term death and need for dialysis. It is defined as kidney damage that has continued for more than 3 months as characterized by structural or functional abnormalities of the kidney, with or without decreased glomerular filtration rate (GFR). It is also defined as GFR < 60mL/min/1.73 m2 for more than 3 months, with or without structural kidney damage. The PCT level in healthy individual without infection is below the limit of detection (0.01 ng/mL), and it is significantly elevated under the stimulation of pathogens. However, ... |
ROFIDA SAADELDIN FARGHALY; | 2022-11-01 |
| 450 | Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, A Comparison to Conventional Histopathological Findings for The Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Kidney biopsy play a key role for the investigation of either acute kidney injury or chronic kidney disease. Despite possible complications due to the invasive nature of the biopsy, such procedure is still essential in a number of clinical situations to improve the diagnosis specificity of kidney disease, better inform about its prognosis and guide the management of a future treatment. Pursuing the idea to improve both performance and rapidity associated with the histopathological analysis of kidney biopsy, with a possible recourse to artificial intelligence-based renal pathology, … |
THOMAS MALDINEY; | 2022-11-01 |
| 451 | Electrocardiograph Changes and Holter Abnormalities in Children With Predialytic Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: CKD is a strong risk factor for cardiovascular disease and mortality , As in adults, cardiovascular disease occurs in some children with CKD before they reach ESRD as well as after |
WETHAB KHALED MOHAMED; | 2022-11-01 |
| 452 | COVID-19 Related Outcomes Among Cancer Patients Treated With TKIs, Including RegorafeNib or SorAfenib PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study in which data from people with cancer who had the Coronavirus disease 2019 (COVID-19) are collected and studied. In observational studies, only observations are made without specified advice or interventions. The most recently discovered coronavirus (SARS-CoV-2) may cause illness in humans ranging from the common cold to serious illness, also known as COVID-19. People with cancer are particularly at risk of becoming very sick with COVID-19, especially during or shortly after a cancer treatment. Several treatments for COVID-19 have been tested in clinical studies. However, … |
BAYER | 2022-10-31 |
| 453 | Open-label, Randomized Comparative Clinical Trial on The Clinical Effect of App-based Education Program in Patients With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: A randomized control trial to test the effect of a mobile app-based educational program for Chronic Kidney Disease patients. |
HOSEOK KOO; | 2022-10-27 |
| 454 | A Phase 2b / 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Combined Dose-Finding and Cardiovascular Outcome Study to Investigate The Efficacy and Safety of CSL300 (Clazakizumab) in Subjects With End Stage Kidney Disease Undergoing Dialysis PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double-blind, placebo-controlled study. Part 1 (phase 2b) is a dose-finding study for CSL300 vs placebo. Part 2 (phase 3) aims to assess the efficacy of CSL300 on cardiovascular (CV) outcomes and safety in subjects with systemic inflammation and either atherosclerotic cardiovascular disease (ASCVD) or diabetes with end stage kidney disease (ESKD) undergoing maintenance dialysis. |
CSL BEHRING | 2022-10-21 |
| 455 | A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of The Efficacy, Safety, and Pharmacokinetics of Two Doses of INV-202 in Patients With Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The study is designed to assess the efficacy, safety, tolerability, and transformation within the human body of INV-202 investigational drug in the treatment of adult participants with a diagnosis of Diabetic Kidney Disease due to either Type 1 diabetes mellitus or Type 2 diabetes mellitus |
JAMES THRASHER; | 2022-10-19 |
| 456 | Mechanisms of Left Ventricular Remodeling in Hypertensive Patients Working on A Rotational Expeditionary Basis in The Conditions of The Arctic Region PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic. |
LIUDMILA GAPON; | 2022-10-16 |
| 457 | Early Vasopressors in Sepsis PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Sepsis is a life-threatening reaction to an infection. It happens when the immune system overreacts to an infection and starts to damage the body’s tissues and organs. The aim of this research study is to compare the two different ways to treat sepsis, in the early phase of treatment immediately after the participants arrive in hospital. The standard approach is to give a salt solution fluid through a drip in the participants arm to start with, … |
NHS GREATER GLASGOW AND CLYDE | 2022-10-11 |
| 458 | Molecular Mechanisms of SGLT2 Inhibition in Diabetic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Canagliflozin is an oral drug which is currently approved for use in patients with type 2 diabetes by the US Food and Drug Administration (FDA). Canagliflozin acts by increasing salt and sugar loss in the urine, and has shown to protect heart, kidney, and blood vessel function in patients with type 2 diabetes. However, it is unknown how canagliflozin protects the kidneys from disease. Therefore, this study plans to learn more about how canagliflozin works to protect against diabetic kidney disease in adults with type 2 diabetes. This study will use state-of-the-art kidney imaging, … |
PETTER MPETTER BJORNSTAD; | 2022-10-10 |
| 459 | Open-label, Multicenter, Randomized, Controlled Trial of Hemodynamic Optimization Based on The Hypotension Prediction Index (HPI) Compared to Standard Practice in Adult Patients Undergoing Elective Major Abdominal Surgery PF:4 Related Papers Related Patents Related Grants Related Experts View Highlight: MAIN AIM OF THE STUDY To establish whether hemodynamic management guided by the hypotension prediction index (HPI) guided by the administration of intravenous fluids and vasoactive drugs in patients undergoing elective major abdominal surgery reduces the incidence of postoperative moderate-severe acute kidney injury (AKI) in the 30 days after surgery. STUDY DESIGN A low intervention level clinical, blinded, controlled, randomized, multicenter, with daily follow-up of patients until hospital discharge and of postoperative complications and mortality 30 days after surgery will be performed. This is a low-intervention clinical trial comparing standard treatments: – … |
MARIA JOSÉ CLARA COLOMINA SOLER; | 2022-10-08 |
| 460 | A Phase 1b, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study in Patients With Autosomal Dominant Polycystic Kidney Disease to Evaluate The Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RGLS8429 PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Primary Objectives – To assess the safety and tolerability of RGLS8429 – To assess the impact of RGLS8429 on ADPKD biomarkers Secondary Objectives – To assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) – To characterize the pharmacokinetic (PK) properties of RGLS8429 – To assess the impact of RGLS8429 on renal function |
REGULUS THERAPEUTICS | 2022-10-06 |
| 461 | A Study to Assess The Effects of The Endothelin Receptor Antagonist Zibotentan and The SGLT2 Inhibitor Dapagliflozin in Patients With Type 2 Diabetes and Elevated Albuminuria: A Randomized Double Blind Cross-Over Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to test the hypothesis that the effects on albuminuria of combination treatment with the endothelin receptor antagonist zibotentan and SGLT2i dapagliflozin are complimentary and additive while the fluid retaining effects of zibotentan can be mitigated by dapagliflozin. |
HIDDO J LAMBERS HEERSPINK; | 2022-10-06 |
| 462 | Initial Safety Study of The TRUE AVC in Hemodialysis Access (TRUE AVC I Study) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Prospective, nonrandomized, single-arm, single-center, open-label, initial safety study in subjects requiring hemodialysis. Subjects will be followed with physical evaluation and ultrasound vessel imaging at days 15, 29, 57 and weeks 12, 26. Extended follow up on patent conduits only at weeks 52 and 104. |
ERNESTO ALVARADO; | 2022-10-04 |
| 463 | FINErenone DruG Utilization Study and Assessment of Temporal Changes Following Availability of Different Treatment Options in Patients With Chronic Kidney Disease and Type 2 Diabetes PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an observational study in which data from people with chronic kidney disease (CKD) and type 2 diabetes (T2D) who have already started or will start CKD or T2D treatment are collected and studied. In observational studies, only observations are made without specified advice or interventions. People receiving the following CKD or T2D treatments as recommended by their doctors will be included: – Sodium-glucose cotransporter 2 inhibitors (SGLT2i), – Glucagon-like peptide-1 receptor agonists (GLP-1 RA), – Steroidal mineralocorticoid receptor antagonists (sMRA), – Finerenone, a non-steroidal mineralocorticoid receptor antagonist (nsMRA) – … |
BAYER | 2022-10-01 |
| 464 | Incidence and Risk Factors of Postoperative Pulmonary Complications in Elderly Patients Undergoing Robot Assisted Laparoscopic Pelvic Surgery: A Single Center, Prospective, Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Postoperative pulmonary complications are important factors affecting the prognosis of patients undergoing surgery. Studies have shown that patients undergoing abdominal or pelvic surgery, emergency surgery, or prolonged surgery are more likely to develop PPCs, especially when robot-assisted laparoscopic surgery is performed at extreme head low. The incidence of PPCs and associated risk factors in patients undergoing robot-assisted laparoscopic surgery compared with those undergoing conventional surgery should be re-examined. |
FENG GAO; | 2022-10-01 |
| 465 | Serum Neutrophil Gelatinase-associated Lipocalin (NGAL) As A Predictor of Renal Injury in Patients With Multiple Myeloma PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study was to evaluate SERUM neutrophil gelatinase-associated lipocalin, emerging indicator of tubular damage and examine their relationship with established measures of renal function (serum creatinine, and estimated glomerular filtration rate, eGFR) among MM patients with and without renal impairment (RI), and at various stages of MM progression. |
EHAB A. ABDELMENAM; | 2022-10-01 |
| 466 | Effect of Adding Lactoferrin to Oral Iron Supplementation for The Treatment of Iron Deficiency Anemia in Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to evaluate the effects of adding lactoferrin to the every-other-day oral iron supplementation in iron deficiency anemia and chronic kidney disease patients. |
AHMED F ELKORAIE; | 2022-10-01 |
| 467 | Correlation Between The Serum Chloride Levels and The Anion Gap Values in The Initial Fluid Resuscitation in DKA Patients and Its Relation to Outcome PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: 2.2 Aim(s) of the Research (50 words max): 1. To examine the description and correlation of changes in the serum chloride levels and changes in the anion gap values before and after fluid resuscitation in patients with DKA and to examine the description and correlation of changes in the serum chloride. 2. relation of serum chloride and outcome in patients with DKA |
MERVAT MOKHLES FATHI SAYED; | 2022-10-01 |
| 468 | Role Of Serum Adiponectin In The Ealy Detection Of Renal Impairment In Patients With Non Alcoholic Fatty Liver Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Early detection of renal impairment in patients with Non-alcoholic fatty liver disease and its correlation with serum Adiponectin level. |
MUSTAFA ABDELRAFE SAYED; | 2022-10-01 |
| 469 | Intra Dialytic Parenteral Nutrition During Intermittent Hemodialysis Can Close The Nutritional Gap Identified By Indirect Calorimetry: A Pilot and Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Renal failure is a relevant condition as the incidence of patients treated with intermittent dialysis continues to grow each year. One of the strongest predictors of mortality in these patients is Protein-Energy Wasting (PEW). Optimal nutritional support, combined with physical exercise may be able to improve the physical condition objectified as muscle wasting and weakness. Correct nutritional support must aim to supplement the correct combination of protein and caloric needs. Although no other way exist than predicting formula to assess protein need, … |
ELISABETH DE WAELE; | 2022-10-01 |
| 470 | A Randomized Double-Blind Cross-over Trial to Study The Effects of Resistant Starch Prebiotic Effects in Chronic Kidney Disease (ReSPECKD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: In patients with Chronic Kidney Disease (CKD), there is a buildup of nitrogenous uremic toxins of gut microbiome origin, which can contribute to uremic symptoms, reduced quality of life, and earlier progression to dialysis. The goal of this project is to investigate whether the consumption of resistant potato starch (RPS) as an adjunctive therapy to current standard of CKD care will reduce uremic toxins and symptoms by altering the gut microbiota in patients with CKD. |
DYLAN MACKAY; | 2022-09-27 |
| 471 | Relation Between Acute Kidney Injury and Mineral Bone Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Abstract: Assiut Medical School Research Proposal Form 2 Part 2: Research Details 2.1 Background (Research Question, Available Data from the literature, Current strategy for dealing with … |
ASMAA AHMED MOHAMED ABD ELRAHEEM; | 2022-09-25 |
| 472 | Evaluation of Protective Effect of Activated Charcoal and Probiotic Against Progression of Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Investigate the nephroprotective effect of Activated Charcoal and Probiotic in limiting the progression of renal impairment in patients with chronic kidney disease and improving of renal function test and phosphate level. Condition or disease: chronic kidney disease |
WALEED KHAILD RAHMAN KAREEM AL-KABI; | 2022-09-25 |
| 473 | The Impact of Pharmacist – Led Mobile Application on Medication Adherence and Efficacy in Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of the study is to assess the impact of pharmacist led mobile application on adherence and efficacy of medication in chronic kidney disease patients |
SHAZA GAMAL; | 2022-09-17 |
| 474 | Study of The Quantitative Evolution of Circulating Cell-free DNA of Renal Origin in Patients With Acute Renal Failure PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The amount of total circulating DNA has been shown to increase in patients with acute renal failure. Nevertheless, it is currently not currently possible to prove the renal origin of this circulating DNA. Recently, in healthy subjects, … |
VALERIE CAUDWELL; | 2022-09-10 |
| 475 | Silent Gallbladder Stone in Kidney Transplantation Recipients: Should It Be Treated? PF:6 Related Papers Related Patents Related Grants Related Experts View Highlight: Treatment and follow-up strategies for silent gallbladder (GB) stones in patients before KT (Kidney transplantation) remain unknown. Therefore, we aimed to assess the risk of gallstone-related biliary complications and post-cholecystectomy complications in KT recipients, to elucidate the role of prophylactic cholecystectomy in this population. |
WOO HYUN PAIK; | 2022-09-07 |
| 476 | A PHASE 1, OPEN-LABEL, NON-RANDOMIZED STUDY TO INVESTIGATE THE SAFETY AND PK FOLLOWING MULTIPLE ORAL DOSES OF PF-07321332 (NIRMATRELVIR)/RITONAVIR IN ADULT PARTICIPANTS WITH COVID-19 AND SEVERE RENAL IMPAIRMENT EITHER ON HEMODIALYSIS OR NOT ON HEMODIALYSIS PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to learn about the side effects (safety) of the study medicine PF-07321332 (nirmatrelvir)/ritonavir for the treatment of mild to moderate COVID-19 infection in adults with severe renal impairment. The study will also look at the amounts of study drug in your blood. There will be 24 participants in this study; 12 of them will have severe renal impairment and not be on hemodialysis and 12 of them will be on hemodialysis. All participants in this study will take PF-07321332 (nirmatrelvir)/ritonavir by mouth for 5 days. During this time, … |
PFIZER | 2022-09-07 |
| 477 | Effectiveness of Doppler Renal Resistive Index in Early Detection of Postoperative Acute Kidney Injury in Prolonged Cardiopulmonary Bypass Cardiac Surgeries PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary aim of our study was to investigate the role of renal doppler ultrasonography (USG) and preoperative/postoperative renal resistive index (RRI) in the early prediction of AKI. Our secondary aim is to evaluate perioperative parameters that may cause AKI, to determine the duration of intensive care unit (ICU)/hospitalization and 30-day mortality. |
MUSA HARUN UÇAR; | 2022-09-01 |
| 478 | Assessing The Feasibility of Self-reported MeasUrement of Physical and PsychosOcial Symptoms and Response Tool in Patients on Dialysis- Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a parallel arm, pilot study used to examine the feasibility of electronic patient reported outcome measures (ePROMs) for symptom assessment and monitoring as well as a linked self-management support and decision support information hub (https://symptomcare.org) to facilitate symptom management for patients on maintenance hemodialysis. Two dialysis centers will be included in the study, with one center receiving SUPPORT-Dialysis (intervention arm) and the other receiving standard care (control arm). |
ISTVAN MUCSI; | 2022-09-01 |
| 479 | Clinical Study on The Treatment of Diabetic Kidney Disease With Shenxiao Yuning Decoction With Syndrome of Qi and Yin Deficiency and Blood Stasis PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: To explore the therapeutic effect of Shenxiao Yuning Decoction on albuminuria and the improvement of traditional Chinese medicine syndrome in patients with stage III diabetic kidney disease with Qi and Yin deficiency and blood stasis syndrome. |
LIN LIAO; | 2022-09-01 |
| 480 | A Multi-center, Open-Label, Exploratory Study to Assess The Efficacy of PB in Decreasing The Urine Output and Increasing The Urine Osmolality in Patients With Hereditary Nephrogenic Diabetes Insipidus, Patients With Autosomal Dominant Polycystic Kidney Disease Treated With Tolvaptan, And Severely Polyuric Patients With Previous Lithium Administration (Serendipity-PB1) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this research is to study the effectiveness and safety of the medication PB in slowing the frequent urination related to tolvaptan as long-term treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD), or frequent urination related to inherited nephrogenic diabetes insipidus as an inherited condition or as an acquired condition from prior treatment with lithium. |
FOUAD T. CHEBIB; | 2022-09-01 |
| 481 | The Effect Of Mandala Colouring On Anxiety, Depression, Pain And Quality of Life in Patients Receiving Haemodialysis Treatment PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The research was conducted as an experimental research to determine the effect of mandala painting on pain, anxiety, depression and quality of life in patients undergoing hemodialysis. |
AYŞE NEFISE BAHÇECİK; | 2022-09-01 |
| 482 | Is It Possible to Predict Acute Kidney Damage in Patients Undergoing Open Heart Surgery in The Preoperative Period? PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Aimed to determine whether preoperative biomarkers (Mg, Hgb, CRP, ProBNP) would be helpful in the early diagnosis of CSA-AKI (cardiac surgery-related acute kidney injury) in patients undergoing open heart surgery. |
TUĞBA YÜCEL; | 2022-08-30 |
| 483 | A Multicenter, Randomized, Double-blind, Placebo-controlled 12-Week Study to Evaluate The Safety and Efficacy of Oral Difelikefalin in Advanced Chronic Kidney Disease Subjects With Moderate-to-Severe Pruritus and Not on Dialysis With An Up to 52-Week Long-term Extension PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of oral difelikefalin administered as a 1 mg tablet once daily compared to placebo in reducing the intensity of itch in advanced chronic kidney disease (CKD) patients with moderate-to-severe pruritus and not on dialysis. This study is comprised of an Efficacy Assessment Phase and a Long-term Extension Phase. The Efficacy Assessment Phase includes a double-blind 12-week Treatment Period (Treatment Period 1), and the Long-term Extension Phase includes a double-blind Treatment Period (Treatment Period 2) of up to 52 weeks. |
CARA THERAPEUTICS | 2022-08-26 |
| 484 | The Effect of Osmotic Stress in Erythrocyte Rheology in ESRD Patients PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: End-stage renal disease (ESRD) disrupts erythrocyte deformability due to osmotic imbalances, oxidative stress, and uremic toxins, leading to impaired microcirculation and oxygen transport. Dysregulation of ion channels, particularly the Gardos channel, exacerbates dehydration and eryptosis, further compromising vascular integrity. Given the critical role of erythrocyte flexibility in oxygen delivery, this study investigates its relationship with aerobic capacity in ESRD patients, highlighting potential mechanisms of microvascular dysfunction |
JONG-SHYAN WANG; | 2022-08-24 |
| 485 | A Randomized Trial of Fistula Vs. Graft Arteriovenous Vascular Access in Older Adults With End-Stage Kidney Disease on Hemodialysis PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: This study is to prospectively compare the effectiveness and safety of the two types of arteriovenous access placement (fistula or graft) in older adults with end stage kidney disease and multiple chronic conditions |
MARIANA MUREA; | 2022-08-18 |
| 486 | Impact on Mortality of Screening for Kidney Disease Associated With A Specialized Intervention During Hospitalization in A Territorial Hospital Trust PF:5 Related Papers Related Patents Related Grants Related Experts View Highlight: Kidney disease in its chronic or acute form shares many risk factors for initiation, progression and prognosis with an increase in morbidity and mortality, the length of hospitalization and the cost associated with stages of increasing severity. Its overall estimated prevalence in the general population is 13% and 0.5% from stage 4, for which referral to a nephrologist is recommended to reduce mortality, … |
OLIVIER MORANNE; | 2022-08-16 |
| 487 | LCAT Deficiency Disorders: Natural History and Identification of Biomarkers PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of the LCAT (Lecithin cholesterol acyl transferase) Natural History Study (LCAT NHS) is to help identify people with a mutation in a gene called LCAT, collect and store information about their medical history and disease course, and to assess for associations and follow changes in clinical features and biomarkers of disease. This information will help health care providers better understand the natural history of disease of LCAT deficiency. Study staff will collect information from previous clinical visits such as lab tests, physical exam findings, renal and cardiovascular imaging, findings from kidney biopsies and eye exams, … |
MARINA CUCHEL; | 2022-08-12 |
| 488 | Assessment of The Oral Health Status of Children With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The aim of this study is to compare the oral health findings, salivary parameters and disease-related quality of life of children with different stages of Chronic Kidney Disease(CKD), those undergoing dialysis and transplantation, with healthy children, and to evaluate certain serum biomarkers in children with CKD. |
MARMARA UNIVERSITY | 2022-08-10 |
| 489 | Continuous Glucose Monitoring in Patients With End-Stage Kidney Disease and Burnt-Out Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Twenty participants with end stage kidney disease (ESKD) and burnt-out diabetes, and 20 non-diabetic participants with ESKD will wear a continuous glucose monitoring (CGM) device for 10 days to see if the use of CGM is a better tool to assess glycemic control than glycosylated hemoglobin (HbA1c) in patients with ESKD on dialysis. |
GUILLERMO UMPIERREZ; | 2022-08-10 |
| 490 | Comparative Cardiovascular and Renal Effectiveness and Safety of Empagliflozin and Other SGLT2i in Patients With Type 2 Diabetes (T2D) With and Without Baseline Kidney Disease in The United States PF:9 Related Papers Related Patents Related Grants Related Experts View Highlight: The primary purpose of this research study is to determine the cardiovascular and renal effectiveness and safety of empagliflozin compared to dipeptidyl peptidase-4 inhibitors (DPP4i) in patients with Type 2 Diabetes Mellitus (T2DM) with and without established kidney disease. The secondary purpose of this research study is to determine the cardiovascular and renal effectiveness and safety of any Sodium glucose co-transporter-2 inhibitors (SGLT2i) compared to Glucagon-like Peptide-1 Receptor Agonists (GLP1RA), and empagliflozin compared to GLP1RA in patients with T2DM. |
BOEHRINGER INGELHEIM | 2022-08-08 |
| 491 | An Open-label, Single-dose Study to Assess The Pharmacokinetics of HSK7653 Tablets in Subjects With Varying Degrees of Renal Impairment Compared to The Control Subjects With Normal Renal Function PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: This is an open-label, single-dose study to evaluate the pharmacokinetics, pharmacodynamics and safety of HSK7653 in subjects with mild, moderate, severe renal impairment and subjects with kidney failure compared to the matched control subjects with normal renal function. |
WANG MEIXIA; | 2022-08-04 |
| 492 | A Dose Escalation and Proof-of-Concept Study of Vonsetamig (BCMA × CD3 Bispecific Antibody) for Desensitization of Chronic Kidney Disease Patients in Need of Kidney Transplantation Who Are Highly Sensitized to Human Leukocyte Antigen PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to determine whether vonsetamig will safely decrease anti-HLA antibodies to allow for kidney transplantation. Vonsetamig is being studied for treatment of patients in need of kidney transplantation who are highly sensitized to HLA. The study is looking at several other research questions, including: * Side effects that may be experienced from taking vonsetamig * How vonsetamig works in the body * How much vonsetamig is present in the blood * If vonsetamig works to lower levels of antibodies to HLA |
REGENERON PHARMACEUTICALS | 2022-08-02 |
| 493 | Basic Needs Navigation Intervention to Address Multidimensional Adversity in African Americans With Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: The overarching goal of this proposal is to test the feasibility and preliminary efficacy of a basic needs navigation intervention on improving clinical outcomes, self-care behaviors and quality of life in low-income African Americans with diabetic kidney disease (DKD) experiencing multidimensional adversity. The study objective will be achieved with the following aims: Aim 1: To determine the feasibility of a basic needs navigation intervention as measured by recruitment, session attendance and retention in low-income Africans Americans with DKD experiencing multidimensional adversity. Aim 2: To test the preliminary efficacy of a basic needs navigation intervention on clinical outcomes (hemoglobin A1c, … |
MUKOSO N. OZIEH; | 2022-08-01 |
| 494 | Cerebrovascular Dysregulation in Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD). |
JUSTIN SPRICK; | 2022-08-01 |
| 495 | Assessment of The Effect of Restriction on Alimentary AGE (Advanced Glycation Products) in Progression of Chronic Kidney Disease (CKD) PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Normal-protein and low-AGE through raw or rare proteins diet versus normal-protein and high-AGE diet in stage IIIa-b renal failure patients |
GABRIELLE NORMAND; | 2022-08-01 |
| 496 | Evaluation and Intervention of Intradialytic Physical Therapy in Patients With Chronic Kidney Disease: A Randomized Clinical Trial Protocol PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The objective is to evaluate in adult patients with chronic kidney disease the effect of neuromuscular electrical stimulation (NMES) in the upper limbs associated with a cycle ergometer in the lower limbs, during hemodialysis, on functional capacity and peripheral muscle strength. The hypothesis is that in people with chronic kidney disease on hemodialysis, the addition of neuromuscular electrical stimulation in the upper limbs associated with aerobic training of the lower limbs is superior to aerobic exercise alone in improving functional capacity, peripheral muscle strength, quality of life, safety intervention and patient adherence. |
MARCELA CANGUSSU BARBALHO; | 2022-08-01 |
| 497 | Clinical Value of Plasma Humanin in Acute Kidney Injury PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: The goal of this observational study is to assess the clinical value of humanin in acute kidney injury. The main questions it aims to answer are:whether Humanin can be a novel marker for predicting AKI Researchers will compare humanin concentration in healthy people to see if humanin can be a novel marker for predicting AKI |
LI ZHILIAN; | 2022-08-01 |
| 498 | The Effect of Laughter Therapy on Acceptance of Disease, Adherence to Treatment and Comfort Level in Patients Receiving Hemodialysis Treatment: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts View Highlight: Background: A randomized controlled study was conducted on the effects of laughter therapy on increasing the acceptance of the disease, compliance with treatment and comfort levels in patients receiving hemodialysis treatment. Materials and methods: The study was conducted with 42 (experimental group=21, control group=21) patients treated in the hemodialysis unit. Eight sessions of laughter yoga were applied to the hemodialysis patients in the experimental group for four weeks, two days a week. Data were used on the Patient Information Form, the Acceptance Scale, the End Stage Renal Failure – Compliance Scale, and the Hemodialysis Comfort Scale. |
BETÜL BAL; | 2022-08-01 |
| 499 | Effects of Oral Iron Supplementation on Gut Microbiota in Patients With Chronic Kidney Disease Related Papers Related Patents Related Grants Related Experts View Highlight: The hypothesis of this research is that oral iron prescribed in a single dose in alternate day could mitigate the side effects with regard to intestinal microbiota, inflammation, oxidative stress and improve the hematological profile when compared to daily oral iron prescription |
UNIVERSIDADE FEDERAL FLUMINENSE | 2022-08-01 |
| 500 | Effectiveness of The CDK-SMS Nursing Intervention for Adults With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts View Highlight: Type of Study: a pragmatic randomized clinical trial. Research question How effective is the CKD SMS self-management nursing intervention on self-management behaviors, self-efficacy, and adherence in adults with early-stage CKD compared to usual care? General objective To determine the effectiveness of the self-management nursing intervention (CKD SMS) on self-management behaviors, self-efficacy, and therapeutic adherence in people with CKD in early stages compared to usual care. Target population: Adult men and women with chronic kidney disease in stages 1-4, with different characteristics such as educational level, socioeconomic status, … |
JUDITH MEDELLIN OLAYA; | 2022-07-20 |