Clinical Digest: A Comprehensive Review of Recent Merck Sharp & Dohme Patents (2026-04)
This compilation provides an overview of Merck Sharp & Dohme‘s latest patent inventions. Alongside these patents are potentially related patents, which may include work from Merck Sharp & Dohme or other entities exploring similar therapeutic areas. This resource aims to offer researchers, clinicians, investors, and the broader public insights into Merck Sharp & Dohme’s current research and development pipeline. By presenting patent details alongside related intellectual property (regardless of origin), this compilation facilitates a broader understanding of Merck Sharp & Dohme’s strategic focus and how it potentially compares to direct and indirect competitors in these therapeutic spaces. This information can be valuable for identifying emerging trends in drug development, assessing the commercial potential of specific research programs, and understanding the broader landscape of scientific contributions related to Merck Sharp & Dohme’s patent inventions. (Last updated on: 2026-04-05)
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TABLE 1: Clinical Digest: A Comprehensive Review of Recent Merck Sharp & Dohme Patents (2026-04)
| Title | Applicant/Assignee | Filing Date | Publish Date | Grant Date | |
|---|---|---|---|---|---|
| 1 | MULTIVALENT FZD4, WNT CO-RECEPTOR, AND VEGF BINDING MOLECULES AND USES THEREOF Related Patents View Abstract: Herein are multivalent antibody binding molecules that activate a Wnt/β-catenin signaling pathway comprising a FZD4 receptor binding domain, an LRP5 co-receptor binding domain, … |
EYEBIOTECH; MERCK SHARP & DOHME | 2025-09-04 | 2026-04-02 | |
| 2 | MULTIVALENT FZD4, WNT CO-RECEPTOR, AND VEGF RECEPTOR MOLECULES AND USES THEREOF Related Patents View Abstract: Herein are multivalent antibody binding molecules that activate a Wnt/β-catenin signaling pathway comprising a FZD4 receptor binding domain, an LRP5 co-receptor binding domain, … |
EYEBIOTECH; MERCK SHARP & DOHME | 2025-09-04 | 2026-04-02 | |
| 3 | TABLET FORMULATIONS Related Patents View Abstract: The present disclosure relates to pharmaceutical compositions (e.g., tablets) comprising an human immunodeficiency virus (HIV) capsid inhibitor and a nucleoside reverse … |
GILEAD SCIENCES et. al. | 2025-08-29 | 2026-04-02 | |
| 4 | TREATMENT OF MIGRAINE Related Patents View Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present … |
ALLERGAN PHARMACEUTICALS INTERNATIONAL et. al. | 2025-10-07 | 2026-03-26 | |
| 5 | SOLID DOSAGE FORM OF A SMALL MOLECULE ANTIVIRAL AND USES THEREOF Related Patents View Abstract: The present disclosure relates to oral dosage forms of pharmaceutical formulations that comprise an antiviral nucleoside, one or more compression aids, one or more glidants, and … |
MERCK SHARP & DOHME | 2023-12-11 | 2026-03-26 | |
| 6 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS Related Patents View Abstract: Compounds of Formula (I) or their pharmaceutically acceptable salts can inhibit the G12C, G12D, G12V, and/or G13D mutants of Kirsten rat sarcoma (KRAS) protein and are expected to … |
MERCK SHARP & DOHME | 2023-08-24 | 2026-03-26 | |
| 7 | Digital System Development Lifecycle Related Patents View Abstract: A digital system development lifecycle system processes approval requests for applications. The system generates a risk profile using a questionnaire and selects a set of … |
MERCK SHARP & DOHME et. al. | 2025-09-12 | 2026-03-19 | |
| 8 | KETOREDUCTASE ENZYMES FOR THE SYNTHESIS OF 1,3-DIOL SUBSTITUTED INDANES Related Patents View Abstract: The present disclosure provides ketoreductase enzymes having improved enzymatic properties including the capability of reducing hydroxy indanones to provide diastereomerically … |
MERCK SHARP & DOHME | 2023-07-05 | 2026-03-19 | |
| 9 | MULTIVALENT FZD4, WNT CO-RECEPTOR, AND VEGF RECEPTOR MOLECULES AND USES THEREOF Related Patents View Abstract: Herein are multivalent antibody binding molecules that activate a Wnt/β-catenin signaling pathway comprising a FZD4 receptor binding domain, an LRP5 co-receptor binding domain, … |
EYEBIOTECH; MERCK SHARP & DOHME | 2025-09-04 | 2026-03-12 | |
| 10 | Method and Apparatus for Controlling a Mini-Tablet Manufacturing Machine Incorporating Content Uniformity Testing Requirements Related Patents View Abstract: The present invention relating to a mini-tablet manufacturing machine, such as a mini-tablet sachet filler or mini-tablet press, includes a computer system and equipment control … |
MERCK SHARP & DOHME | 2023-11-17 | 2026-03-05 | |
| 11 | SUSTAINED RELEASE DELIVERY OF A PDE10 INHIBITOR Related Patents View Abstract: The invention relates to a sustained release pharmaceutical composition comprising a tablet core comprising a therapeutically effective amount of a compound selected from Group 1, … |
MERCK SHARP & DOHME | 2023-08-28 | 2026-03-05 | |
| 12 | PROCESSES FOR PREPARING OXAZOLIDINONE COMPOUNDS Related Patents View Abstract: The invention relates to crystalline forms and processes for preparing a compound of Formula I (I) and pharmaceutically acceptable salts thereof which are useful for the treatment … |
MERCK SHARP & DOHME; WERTHENSTEIN BIOPHARMA | 2023-08-07 | 2026-03-05 | |
| 13 | FORMULATIONS COMPRISING ACTRIIA PROTEIN VARIANTS Related Patents View Abstract: In certain aspects, the present disclosure provides stable, liquid pharmaceutical formulations comprising a recombinant fusion protein comprising an extracellular domain (ECD) of … |
MERCK SHARP & DOHME | 2025-09-08 | 2026-02-26 | |
| 14 | METHODS FOR TREATING CHRONIC MYELOMONOCYTIC LEUKEMIA WITH ANTI-ILT3 ANTIBODIES Related Patents View Abstract: This disclosure relates to methods for treating cancer in a subject identified as having chronic myelomonocytic leukemia (CMML), comprising administering an anti-ILT3 antigen … |
MERCK SHARP & DOHME | 2023-07-27 | 2026-02-12 | |
| 15 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS Related Patents View Abstract: Compounds of Formulae (I)-(VII) or their pharmaceutically acceptable salts can inhibit the G12C, G12D, G12V, and/or G13D mutants of Kirsten rat sarcoma (KRAS) protein and are … |
MERCK SHARP & DOHME | 2025-10-09 | 2026-02-05 | |
| 16 | COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS Related Patents View Abstract: The present invention relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R are as defined herein. The present invention also … |
MERCK SHARP & DOHME | 2025-10-08 | 2026-02-05 | |
| 17 | PLIERS FOR ENGAGING ASEPTIC CONNECTION ASSEMBLY Related Patents View Abstract: Pliers for engaging an aseptic connection assembly is disclosed. The pliers has two arms. Each arm includes a hinge portion, a handle portion, and a pair of phalanges. The hinge … |
MERCK SHARP & DOHME | 2024-08-02 | 2026-02-05 | |
| 18 | CRYSTALLINE FORMS OF A PCSK9 INHIBITOR, COMPOSITIONS AND USES Related Patents View Abstract: This disclosure provides crystalline forms of a compound of Formula (I), as well as pharmaceutically acceptable compositions thereof, and methods for their preparation and use in … |
MERCK SHARP & DOHME et. al. | 2023-08-16 | 2026-02-05 | |
| 19 | PHARMACEUTICAL COMPOSITIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND rHuPH20 OR VARIANTS OR FRAGMENTS THEREOF Related Patents View Abstract: The invention provides pharmaceutical compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0% oxidation of Met105 in the … |
MERCK SHARP & DOHME | 2023-07-27 | 2026-02-05 | |
| 20 | PHARMACEUTICAL COMPOSITIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND PH20 VARIANTS OR FRAGMENTS THEREOF Related Patents View Abstract: The invention provides pharmaceutical compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0% oxidation of Met105 in the … |
MERCK SHARP & DOHME | 2023-07-27 | 2026-02-05 | |
| 21 | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations … |
MERCK SHARP & DOHME | 2025-10-01 | 2026-01-29 | |
| 22 | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations … |
MERCK SHARP & DOHME | 2025-10-01 | 2026-01-29 | |
| 23 | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations … |
MERCK SHARP & DOHME | 2025-10-01 | 2026-01-29 | |
| 24 | PYRROLOPYRIDAZINE VEGFR INHIBITORS Related Patents View Abstract: Provided are compounds of formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are VEGFR inhibitors. Also provided are methods of making … |
MERCK SHARP & DOHME | 2025-07-17 | 2026-01-22 | |
| 25 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A PENTA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES Related Patents View Abstract: An insulin conjugate comprising or consisting of a penta-valent sugar cluster is described. In particular aspects, the insulin conjugate displays a pharmacokinetic (PK) and/or … |
MERCK SHARP & DOHME | 2023-11-06 | 2026-01-22 | |
| 26 | COMMUNICATION GENERATION WITH ARTIFICIAL INTELLIGENCE SYSTEM Related Patents View Abstract: A system retrieves, from one or more databases, a set of data comprising rules related to communication preferences, information describing a plurality of candidate subjects for … |
MERCK SHARP & DOHME et. al. | 2024-07-09 | 2026-01-15 | |
| 27 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS Related Patents View Abstract: The present invention is directed to amino and alkyl pyrazolopyrimidine compounds which may be useful as therapeutic agents for the treatment of disorders associated with … |
MERCK SHARP & DOHME | 2025-09-08 | 2026-01-01 | |
| 28 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS Related Patents View Abstract: The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical … |
MERCK SHARP & DOHME | 2025-01-17 | 2026-01-01 | |
| 29 | MACROCYCLIC PEPTIDES TARGETING KRAS Related Patents View Abstract: The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein the variables are as described herein. The compounds or their … |
MERCK SHARP & DOHME | 2023-07-20 | 2026-01-01 | |
| 30 | SUBSTITUTED AMINO TRIAZOLOPYRIMIDINE AND AMINO TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE Related Patents View Abstract: In its many embodiments, the present invention provides certain substituted amino triazolopyrimidine and amino triazolopyrazine compounds of Formula (IA) and Formula (IB): and … |
MERCK SHARP & DOHME | 2025-06-30 | 2025-12-25 | |
| 31 | ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS Related Patents View Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the … |
MERCK SHARP & DOHME | 2025-06-26 | 2025-12-25 | |
| 32 | SUBSTITUTED AMINO TRIAZOLOPYRIMIDINE AND AMINO TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE Related Patents View Abstract: In its many embodiments, the present invention provides certain substituted amino triazolopyrimidine and amino triazolopyrazine compounds of Formula (IA) and Formula (IB): and … |
MERCK SHARP & DOHME | 2025-08-18 | 2025-12-18 | |
| 33 | NEUTRALIZATION ANTIBODY ASSAY METHOD Related Patents View Abstract: This disclosure relates generally to an assay to determine the presence of neutralizing antibody (NAb) in a sample of a subject treated with a drug. … |
MERCK SHARP & DOHME | 2023-09-18 | 2025-12-18 | |
| 34 | POLYPEPTIDES EFFECTIVE AGAINST MULTIPLE CORONAVIRUSES Related Patents View Abstract: Disclosed are single-domain antibodies that can bind (e.g., separately) to at least two spike proteins from different coronaviruses. Additionally disclosed are polypeptides that … |
MERCK SHARP & DOHME | 2023-09-11 | 2025-12-18 | |
| 35 | ENCLOSURE FOR MITIGATION OF LEAKAGE BY SYRINGE ASSEMBLY Related Patents View Abstract: A splash guard engages to a syringe assembly to mitigate splashing of liquid in instances of failure of the syringe assembly. The splash guard forms an enclosure around the … |
MERCK SHARP & DOHME | 2024-06-28 | 2025-12-11 | |
| 36 | METHODS FOR DETERMINING ONE OR MORE CRITICAL QUALITY ATTRIBUTES OF CO-FORMULATED ANTIBODIES Related Patents View Abstract: The present disclosure relates to methods for determining one or more critical quality attributes of co-formulated antibodies. The present disclosure also relates to methods … |
MERCK SHARP & DOHME | 2023-08-02 | 2025-11-27 | |
| 37 | GENOME WIDE TUMOR DERIVED GENE EXPRESSION BASED SIGNATURES ASSOCIATED WITH POOR PROGNOSIS FOR MELANOMA PATIENTS WITH EARLY STAGE DISEASE Related Patents View Abstract: The invention relates to a gene expression based biomarker that is predictive of patient clinical need for treatment that includes a PD-1 antagonist, wherein the gene expression … |
MERCK SHARP & DOHME | 2023-06-14 | 2025-11-20 | |
| 38 | METHOD FOR SUSTAINED DELIVERY OF MRNA VACCINES Related Patents View Abstract: The invention relates to a method of treating a disease or disorder in a patient in need thereof that includes providing an active pharmaceutical ingredient (API) to the patient … |
MERCK SHARP & DOHME | 2023-06-02 | 2025-11-20 | |
| 39 | LABELING SHELL FOR A DRUG VIAL Related Patents View Abstract: In one aspect of the subject invention, a labeling shell is provided for a drug vial having a glass reservoir and an opening sealed by an elastomeric stopper, the labeling shell … |
MERCK SHARP & DOHME | 2025-07-14 | 2025-11-06 | |
| 40 | TABLET COLLECTION DEVICE Related Patents View Abstract: A pneumatic tablet collection device including a tablet collector, a pneumatic rotary actuator, and a rotatable base operatively connected to the tablet collector and the … |
MERCK SHARP & DOHME | 2024-05-02 | 2025-11-06 | |
| 41 | METHODS FOR TREATING CANCER, OR VON-HIPPEL LINDAU DISEASE USING A COMBINATION OF A TIGIT ANTAGONIST, A PD-1 ANTAGONIST, AND A HIF-2-ALPHA INHIBITOR Related Patents View Abstract: Provided herein are methods of treating cancer, or von-Hippel Lindau disease, which comprise administering to a human patient in need thereof: (a) a TIGIT antagonist; (b) a PD-1 … |
MERCK SHARP & DOHME | 2023-05-26 | 2025-10-30 | |
| 42 | RIPK1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula 1 or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as RIPK1 inhibitors and can be useful in preventing, … |
MERCK SHARP & DOHME | 2023-05-17 | 2025-10-23 | |
| 43 | INHIBITORS OF MsbA AS ANTIBIOTICS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present disclosure is directed to certain functionalized dual substituted arene derivatives (e.g., arenesulfonamide, arenesulfamide, areneoxalamide and areneamide derivatives) … |
MERCK SHARP & DOHME | 2023-05-15 | 2025-10-23 | |
| 44 | IMMUNOGENIC COMPOSITIONS FOR HERPES SIMPLEX VIRUS PROTEINS Related Patents View Abstract: The disclosure provides live attenuated measles vectors encoding in their genome one or more heterologous genes for herpes simplex virus (HSV) proteins, e.g., glycoprotein B, … |
MERCK SHARP & DOHME | 2023-06-22 | 2025-10-09 | |
| 45 | MACROCYCLES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I) and (Ia); and pharmaceutically acceptable salts thereof, which are potent inhibitors of … |
MERCK SHARP & DOHME | 2023-05-15 | 2025-10-09 | |
| 46 | INHIBITORS OF MsbA AS ANTIBIOTICS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present disclosure is directed to certain functionalized dual substitute arene derivatives joined by a cyclic or heterocyclic linker of Formula (I); and pharmaceutically … |
MERCK SHARP & DOHME | 2023-05-15 | 2025-10-09 | |
| 47 | ANTI-INTEGRIN ANTIBODIES AND USES THEREOF Related Patents View Abstract: The integrin family of cell adhesion molecules has emerged as key mediators of tissue fibrosis. A pharmacological inhibitor of multiple integrin subtypes is required to produce … |
MERCK SHARP & DOHME | 2023-05-08 | 2025-10-09 | |
| 48 | PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES Related Patents View Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and … |
MERCK SHARP & DOHME | 2024-12-27 | 2025-10-02 | |
| 49 | ANTI-CANCER COMBINATION THERAPIES COMPRISING CTLA-4 AND PD-1 BLOCKING AGENTS Related Patents View Abstract: Anti-cancer combination therapies comprising a CTLA-4 blocking agent and a PD-1 blocking agent are disclosed. In particular, combination therapies are disclosed wherein the CTLA-4 … |
MERCK SHARP & DOHME | 2025-06-03 | 2025-09-18 | |
| 50 | System for Medicinal Supply Monitoring and Management with Controlled Packaging of Medicinal Product Related Patents View Abstract: A medicinal supply management system manages distribution of medicinal supply. The system may implement a pooling algorithm for pooling studies together, across different … |
MERCK SHARP & DOHME et. al. | 2025-03-14 | 2025-09-18 | |
| 51 | SYSTEM FOR MEDICINAL SUPPLY MONITORING AND MANAGEMENT WITH DIGITAL DISPLAY LABELING Related Patents View Abstract: A medicinal supply management system manages distribution of medicinal supply. The system may implement a pooling algorithm for pooling studies together, across different … |
MERCK SHARP & DOHME et. al. | 2025-03-14 | 2025-09-18 | |
| 52 | System for Medicinal Supply Monitoring and Management for Pooled Medicinal Product Across Studies Related Patents View Abstract: A medicinal supply management system manages distribution of medicinal supply. The system may implement a pooling algorithm for pooling studies together, across different … |
MSD INTERNATIONAL et. al. | 2025-03-14 | 2025-09-18 | |
| 53 | OREXIN RECEPTOR AGONISTS Related Patents View Abstract: The present invention is directed to compounds of Formula I which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described … |
MERCK SHARP & DOHME | 2023-05-01 | 2025-09-11 | |
| 54 | STABLE FORMULATIONS OF ANTI-ILT4 ANTIBODIES OR ANTIGEN-BINDING FRAGMENTS THEREROF IN COMBINATION WITH ANTI-PD-1 ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable coformulations of antibodies or antigen-binding fragments thereof that bind to human immunoglobulin-like transcript 4 (ILT4) and PD-1. Also … |
MERCK SHARP & DOHME | 2023-04-25 | 2025-08-28 | |
| 55 | PROCESS FOR PREPARING AGGLOMERATED CRYSTALLINE MEDIUM-CHAIN FATTY ACID SODIUM SALTS Related Patents View Abstract: The process of the present invention is used to prepare agglomerated, crystalline particles of medium chain fatty acid sodium salts, such as sodium caprate. This process comprises … |
MERCK SHARP & DOHME; WERTHENSTEIN BIOPHARMA | 2023-04-19 | 2025-08-28 | |
| 56 | EVALUATING NEURAL NETWORK PREDICTION CONFIDENCE USING GENERATIVE RECONSTRUCTION OF TEST IMAGE Related Patents View Abstract: A system and method are disclosed for evaluating neural network prediction by leveraging generative reconstructions of a test image to assess confidence in the prediction. The … |
MERCK SHARP & DOHME | 2025-02-18 | 2025-08-21 | |
| 57 | PNEUMOCOCCAL CONJUGATE VACCINES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to 26-valent immunogenic compositions comprising 26 different polysaccharide carrier protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2024-05-16 | 2025-08-14 | |
| 58 | INTERACTIVE GOWNING AND GOWNING VERIFICATION Related Patents View Abstract: A device includes a camera, a display and a computer-based analysis subsystem. The computer-based analysis subsystem is configured to perform operations including receiving images … |
MERCK SHARP & DOHME | 2024-01-22 | 2025-07-24 | |
| 59 | METHODS OF SEPARATING HOST CELL LIPASES FROM A PRODUCTION PROTEIN IN CHROMATOGRAPHIC PROCESSES Related Patents View Abstract: Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a … |
MERCK SHARP & DOHME | 2025-01-16 | 2025-07-17 | |
| 60 | MULTI-CARTRIDGE INJECTOR AND METHODS OF MAKING AND USING SAME Related Patents View Abstract: A multi-cartridge injector includes a plunger having a main brace and a pair of stems, each of the pair of stems having a coupler, a pair of stoppers coupled to each coupler of … |
MERCK SHARP & DOHME | 2022-11-01 | 2025-07-17 | |
| 61 | AZAINDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 Related Patents View Abstract: Novel compounds of Formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, … |
MERCK SHARP & DOHME | 2024-12-12 | 2025-07-10 | |
| 62 | PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION Related Patents View Abstract: The present invention provides a compound of Formula I wherein A, M, R , R , R , R , and subscripts m and n are as described herein and pharmaceutical compositions comprising one … |
MERCK SHARP & DOHME | 2023-01-05 | 2025-07-10 | |
| 63 | PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS Related Patents View Abstract: The present disclosure is directed to pyridinone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant … |
MERCK SHARP & DOHME | 2025-03-18 | 2025-07-03 | |
| 64 | ENGINEERED ENZYME FOR PREPARING A HYDROXYLATED INDANONE INTERMEDIATE USEFUL IN THE SYNTHESIS OF BELZUTIFAN Related Patents View Abstract: The present disclosure provides enzymes derived from the fungi c8D (“FoPip4H enzymes”) having improved properties as compared to a naturally occurring wild-type enzyme including … |
MERCK SHARP & DOHME | 2023-07-05 | 2025-07-03 | |
| 65 | PROCESS FOR PREPARING ((1S,2S)-2-(5-METHYLPYRIDIN-2-YL)CYCLOPROPYL)-METHANOL Related Patents View Abstract: The present invention relates to an efficient scalable synthesis of compounds such as (1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methanol, which contains a disubstituted … |
MERCK SHARP & DOHME; ORGANON PHARMA | 2023-03-27 | 2025-07-03 | |
| 66 | PCSK9 ANTAGONIST COMPOUNDS Related Patents View Abstract: Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R , R and R are as defined herein, which compounds have properties for antagonizing PCSK9. Also … |
MERCK SHARP & DOHME | 2024-12-16 | 2025-06-26 | |
| 67 | PROCESS FOR PREPARING ((1S,2S)-2-(5-METHYLPYRIDIN-2-YL)CYCLOPROPYL)METHANOL Related Patents View Abstract: Described is an efficient, scalable synthesis of compounds such as ((1S,2S)-2-(5-methylpyridin-2-yl)cyclo-propyl)m ethanol, which contains a disubstituted cyclopropane with two … |
MERCK SHARP & DOHME | 2023-03-27 | 2025-06-26 | |
| 68 | CONTROLLED RELEASE VACCINE FORMULATIONS Related Patents View Abstract: The present disclosure provides, among other things, a vaccine composition that includes HPV virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) … |
MERCK SHARP & DOHME | 2023-03-23 | 2025-06-26 | |
| 69 | INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 Related Patents View Abstract: Novel compounds of Formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, management, … |
MERCK SHARP & DOHME | 2024-12-12 | 2025-06-19 | |
| 70 | TREATMENT OF MIGRAINE Citation: 1 Related Patents View Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present … |
ALLERGAN PHARMACEUTICALS INTERNATIONAL et. al. | 2025-02-18 | 2025-06-12 | |
| 71 | NON-AROMATIC CYCLIC-PYRIMIDINE ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Related Patents View Abstract: The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at … |
MERCK SHARP & DOHME | 2023-03-06 | 2025-06-12 | |
| 72 | TREATMENT OF MIGRAINE Citation: 1 Related Patents View Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present … |
ALLERGAN PHARMACEUTICALS INTERNATIONAL et. al. | 2025-01-31 | 2025-06-05 | |
| 73 | PHARMACEUTICAL COMBINATIONS AND METHODS OF USE OF AMINO-PYRROLOPYRIMIDINONE COMPOUND Related Patents View Abstract: The application relates to a pharmaceutical combination or combinational therapy comprising a therapeutically effective amount of the compound of Formula (I), or a … |
MERCK SHARP & DOHME; ARQULE; OHIO STATE INNOVATION FOUNDATION | 2023-03-27 | 2025-05-29 | |
| 74 | FUSED PYRAZOLE AMIDE ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Related Patents View Abstract: The present invention relates to Compounds of Formula I: and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at … |
MERCK SHARP & DOHME | 2023-03-08 | 2025-05-29 | |
| 75 | ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE THEREOF Related Patents View Abstract: In its many embodiments, the invention provides compounds of structural Formula (I): (I), and pharmaceutically acceptable salts thereof, wherein, ring A, R , R and R are as … |
MERCK SHARP & DOHME | 2023-02-14 | 2025-05-29 | |
| 76 | PEPTIDE CONJUGATE VACCINE COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALZHEIMER’S DISEASE Related Patents View Abstract: The invention provides compositions and methods for the treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient, such as Alzheimer’s Disease. Such … |
MERCK SHARP & DOHME | 2024-11-14 | 2025-05-22 | |
| 77 | CYCLIC PEPTIDE FOR TRAPPING INTERLEUKIN-1 BETA Related Patents View Abstract: Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X , X , X , R -R , R , R , R , A , A , and subscripts t and w are as herein … |
MERCK SHARP & DOHME | 2024-11-12 | 2025-05-15 | |
| 78 | RIPK1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula I … |
MERCK SHARP & DOHME | 2024-10-31 | 2025-05-15 | |
| 79 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS Citation: 1 Related Patents View Abstract: Compounds of Formulae (I)-(VII) or their pharmaceutically acceptable salts can inhibit the G12C, G12D, G12V, and/or G13D mutants of Kirsten rat sarcoma (KRAS) protein and are … |
MERCK SHARP & DOHME | 2024-10-18 | 2025-05-01 | |
| 80 | DEVICES FOR USE AS BLOOD BRAIN BARRIER MODELS Related Patents View Abstract: In some embodiments, devices for use as blood-brain barrier models are disclosed. The devices may include either a hydrogel component that surrounds a channel formed between a … |
MERCK SHARP & DOHME; WILLIAM MARSH RICE UNIVERSITY | 2024-10-16 | 2025-05-01 | |
| 81 | NEWCASTLE DISEASE VIRUSES AND USES THEREOF Related Patents View Abstract: Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and … |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI; MEMORIAL SLOAN-KETTERING CANCER CENTER; MERCK SHARP & DOHME | 2024-06-07 | 2025-04-24 | |
| 82 | PLASMA KALLIKREIN INHIBITORS Related Patents View Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating … |
MERCK SHARP & DOHME | 2023-01-23 | 2025-03-27 | |
| 83 | PLATFORM FOR ANALYSIS OF HIGH-THROUGHPUT SEQUENCING DATA Related Patents View Abstract: A sequencing data analysis platform can process datasets that include a large number of sequence read. The reads are aligned to one or more reference genomes. Due to sequencing … |
MERCK SHARP & DOHME et. al. | 2024-09-16 | 2025-03-20 | |
| 84 | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS Related Patents View Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na 1.8 channel activity and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2024-11-26 | 2025-03-13 | |
| 85 | MULTIPRODUCT RESIN REUSE (MRR) FOR THE DEVELOPMENT AND CLINICAL MANUFACTURE OF THERAPEUTIC PROTEINS Related Patents View Abstract: The present invention provides a method for multiproduct resin reuse (MRR) utilizing ionic exchange chromatography columns. The methods of the invention outline the cleaning steps … |
MERCK SHARP & DOHME | 2024-08-09 | 2025-03-13 | |
| 86 | METHODS FOR TREATMENT AND PROPHYLAXIS OF HIV AND AIDS Related Patents View Abstract: The present invention is directed to methods for inhibition of HIV reverse transcriptase, treatment of infection by HIV, prophylaxis of infection by HIV, and the treatment, … |
MERCK SHARP & DOHME | 2024-11-13 | 2025-03-06 | |
| 87 | STABLE FORMULATIONS OF ANTI-CTLA4 ANTIBODIES ALONE AND IN COMBINATION WITH PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Citation: 1 Related Patents View Abstract: The invention relates to stable formulations comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4), … |
MERCK SHARP & DOHME | 2024-09-11 | 2025-03-06 | |
| 88 | LYOSPHERE CRITICAL REAGENT KIT Related Patents View Abstract: The present invention provides lyophilized pellets of low concentrations of antibodies in the form of lyospheres. These lyospheres provide pre-measured antibody concentrations … |
MERCK SHARP & DOHME | 2024-11-13 | 2025-02-27 | |
| 89 | TREATMENT OF MIGRAINE Citation: 3 Related Patents View Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present … |
ALLERGAN PHARMACEUTICALS INTERNATIONAL et. al. | 2024-11-12 | 2025-02-27 | |
| 90 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS Related Patents View Abstract: The present disclosure is directed to compounds of Formula I: and their use as anti-viral agents for inhibition of the replication of hRSV and hMPV and treatment and prophylaxis … |
MERCK SHARP & DOHME | 2024-08-15 | 2025-02-27 | |
| 91 | ANTI-TIGIT ANTIBODIES Related Patents View Abstract: The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease. … |
MERCK SHARP & DOHME | 2024-08-05 | 2025-02-27 | |
| 92 | ANTIMALARIAL AGENTS Related Patents View Abstract: Provided are methods of treating malaria comprising administration of compounds of Formula (I), or a pharmaceutically acceptable salt thereof, to a subject in need thereof, … |
MERCK SHARP & DOHME; WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH; MSD R&D | 2022-12-05 | 2025-02-27 | |
| 93 | SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF Related Patents View Abstract: Provided are novel Substituted Thiophene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R , R , R , R , and R are as defined herein, as well as … |
MERCK SHARP & DOHME | 2022-12-15 | 2025-02-20 | |
| 94 | MONOVALENT INTERLEUKIN 12 (IL-12) HETERODIMERIC FC PROTEINS Related Patents View Abstract: Monovalent IL-12 heterodimeric Fc proteins that display attenuated potency at the IL-12 receptor compared to wild-type IL-12 and have an extended half-life compared to wild-type … |
MERCK SHARP & DOHME | 2024-08-08 | 2025-02-13 | |
| 95 | PYRAZOLOPYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES Related Patents View Abstract: Provided are novel Pyrazolopyrimidine Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R , R , R , and R are as defined herein. Also provided are … |
MERCK SHARP & DOHME | 2022-12-13 | 2025-02-13 | |
| 96 | PROCESSES FOR THE FORMULATION OF PNEUMOCOCCAL POLYSACCHARIDES FOR CONJUGATION TO A CARRIER PROTEIN Related Patents View Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from to a carrier protein. These processes are serotype … |
MERCK SHARP & DOHME | 2024-10-25 | 2025-02-06 | |
| 97 | BIOMARKERS FOR PREDICTING ELIGIBILITY FOR AN ANTI-ILT4 AND ANTI-PD-1 COMBINATION THERAPY Related Patents View Abstract: Disclosed herein are biomarkers that correlate with responses to an anti-ILT4 and anti-PD-1 combination therapy. A biomarker that can differentiate responders from non-responders … |
MERCK SHARP & DOHME | 2022-12-15 | 2025-02-06 | |
| 98 | P53 PEPTIDOMIMETIC MACROCYCLES Related Patents View Abstract: Disclosed are p53 peptidomimetic macrocycles, each p53 peptidomimetic macrocycle comprising an i, i+4 olefin staple and a polypeptide tail covalently linked to the p53 … |
MERCK SHARP & DOHME et. al. | 2022-12-05 | 2025-02-06 | |
| 99 | BLOCKING AND NON-BLOCKING SINGLE DOMAIN ANTIBODIES AND USES THEREOF Related Patents View Abstract: The invention relates, in part, to single domain antibody constructs. In particular, the invention relates, in part, to single domain antibody constructs that include a … |
MERCK SHARP & DOHME | 2022-12-01 | 2025-01-30 | |
| 100 | C-TERMINAL EXTENDED P53 ACTIVATOR CROSSLINKED PEPTIDOMIMETIC MACROCYCLES AGAINST MDM2/MDMX Related Patents View Abstract: The crosslinked peptidomimetic macrocycles disclosed herein comprise an alkene or alkyne staple and a poly-amino acid C-terminal tail. These crosslinked peptidomimetic macrocycles … |
MERCK SHARP & DOHME; MSD INTERNATIONAL; AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH | 2022-11-23 | 2025-01-30 | |
| 101 | TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS Related Patents View Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without … |
MERCK SHARP & DOHME | 2024-07-05 | 2025-01-23 | |
| 102 | FUSED PYRAZOLE UREA ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Related Patents View Abstract: The present invention relates to Compounds of Formula (I) and pharmaceutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising … |
MERCK SHARP & DOHME | 2022-11-28 | 2025-01-23 | |
| 103 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS Related Patents View Abstract: The present invention relates to monobactam compounds of Formula I: The present invention also relates to pharmaceutical compositions comprising a monobactam compound of … |
MERCK SHARP & DOHME | 2022-11-16 | 2025-01-16 | |
| 104 | FORMULATIONS OF ANTIVIRAL COMPOUNDS Related Patents View Abstract: The present disclosure is directed to pharmaceutical formulations comprising an amorphous inhibitor of hepatitis C virus NS5A. These pharmaceutical formulations may be prepared by … |
MERCK SHARP & DOHME | 2024-09-23 | 2025-01-09 | |
| 105 | SCALABLE CHROMATOGRAPHY PROCESS FOR PURIFICATION OF HUMAN CYTOMEGALOVIRUS Related Patents View Abstract: The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two … |
MERCK SHARP & DOHME | 2024-07-11 | 2025-01-09 | |
| 106 | COMBINATION OF A PD-1 ANTAGONIST AND A VEGF-R/FGFR/RET TYROSINE KINASE INHIBITOR FOR TREATING CANCER Related Patents View Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a multi-RTK inhibitor, and the use of the combination … |
EISAI R&D MANAGEMENT et. al. | 2024-09-06 | 2025-01-02 | |
| 107 | COMBINATION THERAPIES FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER Related Patents View Abstract: The present disclosure relates to methods of treating a cellular proliferative disorder (e.g., cancer) comprising administering: wherein: Also disclosed are therapeutic … |
MERCK SHARP & DOHME; SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL | 2023-12-07 | 2025-01-02 | |
| 108 | COMBINATION THERAPIES FOR THE TREATMENT OF CANCER Related Patents View Abstract: The present disclosure relates to methods of treating a cellular proliferative disorder (e.g., cancer) comprising administering: wherein: … |
MERCK SHARP & DOHME; SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL | 2023-12-07 | 2025-01-02 | |
| 109 | AMPOULE FOR ORAL VACCINE ADMINISTRATION AND METHODS OF USE Related Patents View Abstract: An ampoule includes a body having a cavity for storing a medicament, a neck coupled to the body and defining a nozzle in communication with the cavity of the body, a removable cap … |
MERCK SHARP & DOHME | 2022-11-11 | 2025-01-02 | |
| 110 | COMPOSITIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF OBTAINING THE COMPOSITIONS THEREOF Related Patents View Abstract: The invention provides compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0% oxidation of Met105 in the CDRH3 heavy chain … |
MERCK SHARP & DOHME | 2024-09-06 | 2024-12-26 | |
| 111 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A TETRA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES Related Patents View Abstract: An insulin conjugate comprising or consisting of a tetra-valent sugar cluster is described. The tetra-valent sugar cluster is provided by tetra-dentate linker having four arms, … |
MERCK SHARP & DOHME | 2022-11-16 | 2024-12-26 | |
| 112 | VIAL-TO-SYRINGE CONVERTER AND METHODS OF MAKING AND USING SAME Related Patents View Abstract: In some examples, a vial-to-syringe converter includes a plunger rod, an adapter including a body having a piercing spike, a receiver and a lumen extending between the spike and … |
MERCK SHARP & DOHME | 2022-11-01 | 2024-12-26 | |
| 113 | MICRONEEDLE INJECTOR AND METHODS OF MAKING AND USING SAME Related Patents View Abstract: In some examples, an injector includes a base, a housing movable relative to the base, a needle unit disposed within the base, the needle unit comprising at least one piercing … |
MERCK SHARP & DOHME | 2022-11-01 | 2024-12-19 | |
| 114 | NANOEMULSION ADJUVANT COMPOSITIONS FOR HUMAN PAPILLOMAVIRUS VACCINES Related Patents View Abstract: The present disclosure provides, among other things, a vaccine composition that includes a squalene nanoemulsion (SNE) adjuvant and HPV virus-like particles (VLPs) of at least one … |
MERCK SHARP & DOHME | 2024-06-06 | 2024-12-12 | |
| 115 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2024-08-22 | 2024-12-05 | |
| 116 | 5,6 UNSATURATED BICYCLIC HETEROCYLES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 Related Patents View Abstract: Novel compounds of the structural formula (I), and pharmaceutically acceptable salts, hydrates and solvates thereof, are inhibitors of NLRP3 and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2024-05-30 | 2024-12-05 | |
| 117 | COMPOUNDS AND ADJUVANT FORMULATIONS USEFUL IN PNEUMOCOCCAL VACCINES Related Patents View Abstract: The invention relates to novel compounds and formulations. Further, the invention relates to novel compounds and formulations useful in pneumococcal and pneumococcal conjugate … |
MERCK SHARP & DOHME | 2024-05-16 | 2024-11-28 | |
| 118 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2024-08-02 | 2024-11-21 | |
| 119 | POLYNUCLEOTIDES ENCODING NOROVIRUS VP1 ANTIGENS AND USES THEREOF Related Patents View Abstract: The present invention is directed to nucleic acids and related immunogenic polypeptides for the prevention or treatment of infectious diseases. In particular, the nucleic acids … |
MERCK SHARP & DOHME | 2024-05-06 | 2024-11-14 | |
| 120 | STREPTOCOCCUS PNEUMONIAE SEROTYPE SPECIFIC PCR PAD ASSAY Related Patents View Abstract: The invention described herein relates to a high-throughput and multiplex ( ) serotype (ST)-specific polymerase chain reaction-pneumococcal antigen detection (PCR-PAD) assay … |
MERCK SHARP & DOHME | 2024-04-23 | 2024-11-14 | |
| 121 | TROP2 BINDERS AND CONJUGATES THEREOF Related Patents View Abstract: TROP2 binders and variants thereof are described. In a specific embodiment, the TROP2 binders that are antibodies that preferentially bind high-expressing TROP2 cells over … |
MERCK SHARP & DOHME | 2024-04-22 | 2024-10-31 | |
| 122 | EVALUATING PRODUCTION BATCHES USING MACHINE-LEARNING Related Patents View Abstract: A method or a system for automated product inspection. The system receives multiple images of products captured from various perspectives. For each image, a machine-learning model … |
MERCK SHARP & DOHME et. al. | 2024-04-18 | 2024-10-24 | |
| 123 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof Citation: 1 Related Patents View Abstract: Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise … |
ALIGOS THERAPEUTICS et. al. | 2024-03-07 | 2024-10-24 | |
| 124 | METHODS FOR MAKING POLYSACCHARIDE-PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by … |
MERCK SHARP & DOHME | 2024-06-28 | 2024-10-17 | |
| 125 | STREPTOCOCCUS PNEUMONIAE SEROTYPE-SPECIFIC DETECTION ASSAY, REAGENTS AND KITS Related Patents View Abstract: is a major cause of community-acquired pneumonia (CAP) in young children, older adults, and those with conditions or medications that compromise their immunity. Since the … |
MERCK SHARP & DOHME | 2024-04-03 | 2024-10-10 | |
| 126 | IL4I1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein R , R , A, and B are as defined herein. The compounds of Formula I act as IL4I1 … |
MERCK SHARP & DOHME | 2024-03-27 | 2024-10-10 | |
| 127 | PREPARATION OF OXINDOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS Related Patents View Abstract: Invented are compounds of formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making … |
MERCK SHARP & DOHME | 2024-05-23 | 2024-10-03 | |
| 128 | ENZYMATIC SYNTHESIS OF 4′-ETHYNYL NUCLEOSIDE ANALOGS Related Patents View Abstract: The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on … |
MERCK SHARP & DOHME | 2024-05-28 | 2024-09-12 | |
| 129 | PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES Citation: 1 Related Patents View Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and … |
MERCK SHARP & DOHME | 2024-04-29 | 2024-09-12 | |
| 130 | PROCESS FOR PREPARING BETA 3 AGONISTS AND INTERMEDIATES Citation: 1 Related Patents View Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and … |
MERCK SHARP & DOHME | 2023-11-14 | 2024-09-12 | |
| 131 | ANTI-FOLR1 IMMUNOCONJUGATES AND ANTI-PD-1 ANTIBODY COMBINATIONS Related Patents View Abstract: Therapeutic combinations of immunoconjugates that bind to FOLR1 (e.g., IMGN853) with anti-PD-1 antibodies or antigen-binding fragments thereof (e.g., pembrolizumab) are provided. … |
IMMUNOGEN; MERCK SHARP & DOHME | 2023-10-18 | 2024-09-12 | |
| 132 | Static Multiomic Seed Approach for Identifying Molecular Signatures Related Patents View Abstract: Disclosed is a method for obtaining a dataset containing data values for a plurality of parameters corresponding to biological factors. Seed features that are known to be … |
MERCK SHARP & DOHME | 2023-03-07 | 2024-09-12 | |
| 133 | IDENTIFYING BIOSYNTHETIC GENE CLUSTERS Related Patents View Abstract: A biosynthetic gene cluster (BGC) prediction system identifies candidate BGCs within genomes using an iteratively trained machine-learned model. The system identifies, in a genome … |
MERCK SHARP & DOHME et. al. | 2024-05-03 | 2024-08-29 | |
| 134 | CYCLIC PEPTIDES FOR INHIBITING TNF RECEPTOR 1 ACTIVITY Related Patents View Abstract: Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, … |
MERCK SHARP & DOHME | 2024-02-01 | 2024-08-29 | |
| 135 | PRODRUGS OF 4′-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS Related Patents View Abstract: The present invention is directed to prodrugs of compound A: which are nucleoside reverse transcriptase translocation inhibitors (NRTTI) and are useful in the inhibition of HIV … |
MERCK SHARP & DOHME | 2024-01-26 | 2024-08-29 | |
| 136 | METHODS FOR PRODUCING STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDE CARRIER PROTEIN CONJUGATES Related Patents View Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal … |
MERCK SHARP & DOHME | 2024-04-17 | 2024-08-08 | |
| 137 | SOLID DOSAGE FORMULATIONS OF AN OREXIN RECEPTOR ANTAGONIST Related Patents View Abstract: The present invention is directed to a pharmaceutical composition comprising the compound suvorexant, or a pharmaceutically acceptable salt thereof, a concentration-enhancing … |
MERCK SHARP & DOHME | 2024-04-09 | 2024-08-08 | |
| 138 | PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE 0-ACYLTRANSFERASE 2 INHIBITORS Related Patents View Abstract: Provided are compounds of Formula I, Formula Ia and Formula Ib and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided … |
MERCK SHARP & DOHME | 2023-11-30 | 2024-08-01 | |
| 139 | CYCLOHEXYLGYCINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS Related Patents View Abstract: The present disclosure is directed to cyclohexylglycine derivatives of Formula I and their use as HIV-infected cell kill agents which accelerate the death of HIV GAG-POL … |
MERCK SHARP & DOHME | 2022-12-22 | 2024-08-01 | |
| 140 | ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS Related Patents View Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the … |
MERCK SHARP & DOHME | 2024-04-09 | 2024-07-25 | |
| 141 | SOLUTION FORMULATIONS OF ENGINEERED ANTI-IL-23p19 ANTIBODIES Related Patents View Abstract: The present invention provides high concentration solution formulations of anti-human interleukin-23 p19 (IL-23p19) antibody hum1388-b, and their use in treating various disorders. … |
MERCK SHARP & DOHME | 2024-01-05 | 2024-07-18 | |
| 142 | ANTI-ILT4 ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS Related Patents View Abstract: The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an … |
MERCK SHARP & DOHME; AGENUS | 2023-12-20 | 2024-07-11 | |
| 143 | COMBINATION THERAPIES FOR TREATING CANCER Related Patents View Abstract: The present invention provides methods of treatment for recurrent cancer(s) through combination therapy with an agent that inhibits programmed death-1 protein (PD-1) signaling and … |
TESARO; MERCK SHARP & DOHME | 2023-12-15 | 2024-07-11 | |
| 144 | PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION Related Patents View Abstract: The present invention provides a compound of Formula I wherein R , R , R , R , R , R , R , and subscripts x and n are as described herein and pharmaceutical compositions … |
MERCK SHARP & DOHME | 2023-11-20 | 2024-07-11 | |
| 145 | ROBOT TASK SCHEDULER WITH VERIFIED AUDIT TRAIL Related Patents View Abstract: A GUI is used to schedule a set of tasks for one or more robots to test samples using one or more instruments. A set of drivers are used to map instructions for the robots and … |
MERCK SHARP & DOHME | 2023-10-20 | 2024-07-11 | |
| 146 | BLOW-FILL SEALING METHOD FOR FILLING AND PACKAGING Citation: 1 Related Patents View Abstract: A method of controlling a temperature of a biopharmaceutical product during blow-fill sealing, includes developing a model based on heat transfer mechanisms that incorporates the … |
MERCK SHARP & DOHME | 2023-10-11 | 2024-07-11 | |
| 147 | AURISTATIN LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present disclosure is directed to linker-payloads, and pharmaceutically acceptable salts, solvates, or stereoisomer thereof, comprising a structure of formula I: The … |
MERCK SHARP & DOHME | 2023-12-12 | 2024-06-27 | |
| 148 | EXATECAN-DERIVED ADC LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present disclosure is directed to linker-payloads, and salts (including pharmaceutically acceptable salts), solvates, or stereoisomers thereof, comprising a structure of … |
MERCK SHARP & DOHME | 2023-10-23 | 2024-06-27 | |
| 149 | CONVOLUTIONAL NEURAL NETWORK FOR SUBVISIBLE PARTICULATE CLASSIFICATION OF BIOPHARMACEUTICALS Related Patents View Abstract: An analysis system implements a particulate classification model trained as a convolutional neural network to assess sterile formulation quality. The system obtains micro flow … |
MERCK SHARP & DOHME | 2023-12-20 | 2024-06-20 | |
| 150 | STABLE FORMULATIONS OF ANTI-TIGIT ANTIBODIES ALONE AND IN COMBINATION WITH PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The present invention relates to stable formulations of antibodies against T cell immunoreceptor with Ig and ITIM domains (TIGIT), optionally further containing an anti-human … |
MERCK SHARP & DOHME | 2024-01-25 | 2024-06-06 | |
| 151 | 3D SEGMENTATION OF LESIONS IN CT IMAGES USING SELF-SUPERVISED PRETRAINING WITH AUGMENTATION Related Patents View Abstract: A method or system for training a convolutional neural network (CNN) for medical imaging analysis. The system pre-trains the CNN’s encoder using a dataset of unlabeled 3D medical … |
MERCK SHARP & DOHME | 2023-11-28 | 2024-05-30 | |
| 152 | PRO DRUGS OF PDE10 COMPOUNDS Related Patents View Abstract: The present invention is directed to pro drugs of 2-methyl-N-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-6-((( S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-4-amine … |
MERCK SHARP & DOHME | 2023-12-13 | 2024-05-16 | |
| 153 | MULTI-DIMENSION UNIFIED SWIN TRANSFORMER FOR LESION SEGMENTATION Related Patents View Abstract: A system and method of multi-stage training of a transformer-based machine-learning model. The system performs at least two stages of the following three stages of training: … |
MERCK SHARP & DOHME | 2023-11-07 | 2024-05-16 | |
| 154 | COMPOSITIONS AND METHODS FOR TREATING CANCER WITH SUBCUTANEOUS ADMINISTRATION OF ANTI-PD1 ANTIBODIES Citation: 1 Related Patents View Abstract: The invention relates to compositions and methods for treating cancer in a patient comprising subcutaneously administering a PD-1 antagonist, e.g., an anti-PD-1 antibody (e.g. … |
MERCK SHARP & DOHME | 2023-10-11 | 2024-05-09 | |
| 155 | RECIPROCAL INJECTION DEVICE AND METHODS OF USING SAME Related Patents View Abstract: In some embodiments, a reciprocal injection device includes a platform having a motor, a gearbox operatively coupled to the motor, an actuation slide driven by the motor, a pair … |
MERCK SHARP & DOHME | 2023-10-19 | 2024-05-02 | |
| 156 | ENHANCING IMMUNOGENICITY OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES Related Patents View Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from bacterial capsules are … |
MERCK SHARP & DOHME | 2023-06-22 | 2024-05-02 | |
| 157 | FORMULATIONS OF DENGUE VIRUS VACCINE COMPOSITIONS Related Patents View Abstract: The present invention relates to formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a … |
MERCK SHARP & DOHME | 2023-12-06 | 2024-04-25 | |
| 158 | PHTHALAZINE DERIVATIVES USEFUL AS INHIBITORS OF NOD-LIKE RECEPTOR PROTEIN 3 Related Patents View Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of NLRP3 and may be useful in the treatment, prevention, … |
MERCK SHARP & DOHME | 2023-09-21 | 2024-04-18 | |
| 159 | PROTEINS BINDING NKG2D, CD16, AND CEACAM5 Related Patents View Abstract: Multi-specific binding proteins that bind NKG2D, CD16, and CEACAM5 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer … |
MERCK SHARP & DOHME et. al. | 2023-08-08 | 2024-04-18 | |
| 160 | STERILE LINE CLIP SEPARATION TOOL Related Patents View Abstract: A system and a method are disclosed for disconnecting clips. A clip separation tool includes two arms, the arms having jaws to receive connected clips at a distal end of the arms … |
MERCK SHARP & DOHME | 2023-12-04 | 2024-04-11 | |
| 161 | EXATECAN-DERIVED TOPOISOMERASE-1 INHIBITORS PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Related Patents View Abstract: The present disclosure is directed to alcohol and amine containing exatecan derivatives, and pharmaceutically acceptable salts or solvates thereof, comprising a structure of … |
MERCK SHARP & DOHME | 2023-08-31 | 2024-04-11 | |
| 162 | METHODS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F Related Patents View Abstract: The present invention provides a method of producing a polysaccharide—protein conjugate with capsular polysaccharide from serotype 19F conjugated to a carrier protein. The method … |
MERCK SHARP & DOHME | 2023-12-15 | 2024-04-04 | |
| 163 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2023-11-09 | 2024-04-04 | |
| 164 | HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA-GAMMAC DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER Related Patents View Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor βγ dimer over binding the IL-2 receptor αβγ trimer … |
MERCK SHARP & DOHME | 2023-10-11 | 2024-03-28 | |
| 165 | CLINICAL INVESTIGATION TIMELINESS PREDICTOR Related Patents View Abstract: A clinical investigation management system monitors clinical investigations performed across departments and clinical investigators. The system employs a method for predicting … |
MSD CZECH REPUBLIC et. al. | 2023-09-12 | 2024-03-21 | |
| 166 | METHODS FOR TREATING CANCER OR INFECTION USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY, AN ANTI-LAG3 ANTIBODY, AND AN ANTI-TIGIT ANTIBODY Related Patents View Abstract: Provided herein are methods of treating cancer or infection, which comprise administering to a human patient in need thereof: (a) an anti-human PD-1 monoclonal antibody or antigen … |
MERCK SHARP & DOHME | 2023-09-06 | 2024-03-21 | |
| 167 | Small Molecule Inhibitors of KRAS G12C Mutant Citation: 5 Related Patents View Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W , W , Y, Z, M, L, C , C , R , R , R , R , R , R , R , and the subscripts … |
MERCK SHARP & DOHME | 2023-05-03 | 2024-03-14 | |
| 168 | NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS Related Patents View Abstract: Invented are compounds of formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making … |
MERCK SHARP & DOHME | 2023-09-12 | 2024-02-22 | |
| 169 | FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND CO-FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES Related Patents View Abstract: The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various … |
MERCK SHARP & DOHME | 2023-10-12 | 2024-02-15 | |
| 170 | Small Molecule Inhibitors of KRAS G12C Mutant Citation: 5 Related Patents View Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W , W , Y, Z, M, L, C , C , R , R , R , R , R , R , R , and the subscripts … |
MERCK SHARP & DOHME | 2023-05-03 | 2024-02-08 | |
| 171 | METHODS FOR TREATING CANCER WITH ANTI-PD-1 ANTIBODIES Related Patents View Abstract: The present invention relates to methods for treating cancer in a patient comprising administering a PD-1 antagonist, e.g., an anti-PD-1 antibody or antigen binding fragment … |
MERCK SHARP & DOHME | 2023-09-01 | 2024-01-25 | |
| 172 | RIPK1 INHIBITORS AND METHODS OF USE Related Patents View Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as RIPK1 inhibitors and can be useful in preventing, … |
MERCK SHARP & DOHME | 2023-05-17 | 2024-01-25 | |
| 173 | DENSIFIED CO-PRECIPITATED MATERIALS ISOLATED BY THIN FILM EVAPORATION Related Patents View Abstract: The invention encompasses a process for densifying co-precipitated material comprised of an active pharmaceutical ingredient and at least one stabilizing excipient using thin film … |
MERCK SHARP & DOHME | 2023-07-07 | 2024-01-11 | |
| 174 | NOVEL SYNTHETIC PATHWAY TO BELZUTIFAN Related Patents View Abstract: The disclosure provides a novel process and synthetic intermediates for making belzutifan, a HIF-2a inhibitor, useful for the treatment of certain VHL-related indications and … |
MERCK SHARP & DOHME | 2023-07-03 | 2024-01-11 | |
| 175 | COMPOSITIONS AND METHODS FOR TREATING CANCER WITH A COMBINATION OF AN ANTAGONIST OF PD-1 AND AN ANTI-CTLA4 ANTIBODY Related Patents View Abstract: The present invention relates to methods for treating cancer comprising administering an antagonist of PD-1, e.g., anti-PD-1 antibody or antigen binding fragment thereof, and an … |
MERCK SHARP & DOHME | 2022-12-12 | 2024-01-11 | |
| 176 | CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA Related Patents View Abstract: Provided are compounds of the Formula (I), or their pharmaceutically acceptable salts, wherein X , X , X , A , A , R -R , R , R , R , R , R and R are as herein described. can trap … |
MERCK SHARP & DOHME | 2023-06-13 | 2023-12-21 | |
| 177 | AZIDE INSULIN ANALOGUES Related Patents View Abstract: The present invention relates to insulin analogues and processes of making such insulin analogues by direct conversion of a free amine to an azide via diazo-transfer with an … |
MERCK SHARP & DOHME | 2023-07-31 | 2023-11-16 | |
| 178 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMO VIRUS Related Patents View Abstract: The present disclosure is directed to compounds of Formula I: and their use as anti-viral agents for inhibition of the replication of hRSV and hMPV and treatment and prophylaxis … |
MERCK SHARP & DOHME | 2023-05-11 | 2023-11-16 | |
| 179 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS Related Patents View Abstract: The present disclosure is directed to compounds of Formula I or a pharmaceutically acceptable salt thereof, and their use for the treatment of hRSV and hMPV. … |
MERCK SHARP & DOHME | 2023-05-11 | 2023-11-16 | |
| 180 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2023-03-23 | 2023-10-26 | |
| 181 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS Related Patents View Abstract: The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical … |
MERCK SHARP & DOHME | 2022-11-10 | 2023-10-19 | |
| 182 | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations … |
MERCK SHARP & DOHME | 2023-03-10 | 2023-10-12 | |
| 183 | 2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS Related Patents View Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na 1.8 channel activity and may be useful in the treatment, … |
MERCK SHARP & DOHME | 2023-06-05 | 2023-10-05 | |
| 184 | ANTI-COAGULATION FACTOR XI ANTIBODIES Related Patents View Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described. … |
MERCK SHARP & DOHME; ADIMAB | 2023-04-18 | 2023-09-14 | |
| 185 | SYRINGES AND INJECTORS WITH CAPACITIVE SENSING AND METHODS OF MAKING AND USING SAME Related Patents View Abstract: An injecting device includes a reservoir for containing a medicament, a needle in communication with the reservoir and configured to deliver the medicament to a patient’s body, at … |
MERCK SHARP & DOHME | 2023-05-15 | 2023-09-07 | |
| 186 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a … |
MERCK SHARP & DOHME | 2023-03-23 | 2023-09-07 | |
| 187 | STABLE FORMULATIONS OF CYTOMEGALOVIRUS Related Patents View Abstract: The present invention relates to stable formulations of a cytomegalovirus (CMV) comprising for example, a genetically modified CMV that is conditionally replication defective, a … |
MERCK SHARP & DOHME | 2022-11-30 | 2023-09-07 | |
| 188 | HPV VACCINE Related Patents View Abstract: The present disclosure provides, among other things, a pharmaceutical composition that includes a lipid nanoparticle adjuvant and an anti-human papillomavirus (HPV) comprising HPV … |
MERCK SHARP & DOHME | 2023-03-10 | 2023-08-31 | |
| 189 | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF Related Patents View Abstract: The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations … |
MERCK SHARP & DOHME | 2023-03-10 | 2023-08-24 | |
| 190 | ADJUVANTED VACCINES Related Patents View Abstract: Vaccine formulations are described comprising physically separated, lyophilized antigens and adjuvant components, which may be in lyoparticle form, as well as methods of using and … |
MERCK SHARP & DOHME | 2023-02-22 | 2023-07-27 | |
| 191 | ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS Related Patents View Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the … |
MERCK SHARP & DOHME | 2022-12-13 | 2023-07-06 | |
| 192 | PNEUMOCOCCAL CONJUGATE VACCINE FORMULATIONS Related Patents View Abstract: The present invention provides pneumococcal conjugate vaccine formulations comprising surfactant systems incorporating polysorbate 20 or a combination of a poloxamer and a polyol. … |
MERCK SHARP & DOHME | 2023-02-15 | 2023-06-29 | |
| 193 | ADJUVANTED VACCINES Related Patents View Abstract: Vaccine formulations are described comprising physically separated, lyophilized antigens and adjuvant components, which may be in lyoparticle form, as well as methods of using and … |
MERCK SHARP & DOHME | 2023-02-22 | 2023-06-22 | |
| 194 | PCSK9 ANTAGONIST COMPOUNDS Related Patents View Abstract: Disclosed are compounds of Formula A, or a pharmaceutically acceptable salt thereof: where A, X, R , and R are as defined herein, which compounds have properties for antagonizing … |
MERCK SHARP & DOHME | 2022-10-31 | 2023-06-01 | |
| 195 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS Related Patents View Abstract: The present invention relates to monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which … |
MERCK SHARP & DOHME | 2022-11-16 | 2023-05-25 | |
| 196 | SCORING METHODS FOR ANTI-PD THERAPY ELIGIBILITY AND COMPOSITIONS FOR PERFORMING SAME Related Patents View Abstract: Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent based on a … |
AGILENT TECHNOLOGIES et. al. | 2023-01-18 | 2023-05-18 | |
| 197 | STABILIZED RSV F PROTEINS AND USES THEREOF Citation: 1 Related Patents View Abstract: The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions … |
MERCK SHARP & DOHME | 2022-12-20 | 2023-05-11 | |
| 198 | PHOSPHONATE LINKERS AND THEIR USE TO FACILIATE CELLULAR RETENTION OF COMPOUNDS Related Patents View Abstract: Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound … |
MERCK SHARP & DOHME | 2022-12-02 | 2023-05-11 | |
| 199 | ANTIBODY DRUG CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS Related Patents View Abstract: Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and … |
MERCK SHARP & DOHME; AMBRX | 2022-10-26 | 2023-03-30 | |
| 200 | IN SILICO PROCESS FOR SELECTING PROTEIN FORMULATION EXCIPIENTS Related Patents View Abstract: The invention relates to an in silico screening method to identify candidate excipients for reducing aggregation of a protein in a formulation. The method combines computational … |
MERCK SHARP & DOHME | 2022-11-04 | 2023-03-23 |