Clinical Digest: Recent Clinical Trials on Arthritis (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Arthritis. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Arthritis (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | THE RELATIONSHIP BETWEEN PROPRIOCEPTION, KINESIOPHOBIA, BALANCE, AND SENSORY PROFILE WITH FUNCTIONAL RECOVERY AFTER GONARTHROSIS SURGERY PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims to investigate the relationships between proprioception, causes of kinesiophobia, sensory processing characteristics, and functional recovery in individuals undergoing gonarthrosis surgery. Postoperative functional recovery can be influenced by sensorimotor and psychological factors such as impaired proprioception, fear of movement, and changes in sensory processing. However, the interaction between these factors has not been sufficiently clarified. Participants will complete a sociodemographic and clinical information form, the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), the Causes of Kinesiophobia Scale, and the Adolescent/Adult Sensory Profile. Proprioception will be assessed using the Joint Position Perception Test. |
HULYA YAMAN; | 2026-03-18 |
| 2 | Real-world Effectiveness and Dosing Patterns of Tirzepatide: A Multicentre Retrospective Observational Study in The Netherlands PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Tirzepatide is one of the new medications for the treatment of obesity. In clinical research people treated with Tirzepatide have weight loss up to 21%. But there is only a little bit of research showing the effect of Tirzepatide in clinical practice. In this retrospective observational study the investigators will evaluate the effectiveness of tirzepatide in routine clinical practice among adults with obesity in the Netherlands.The main questions it aims to answer are: * How much weight do patients lose after six months of treatment with tirzepatide combined with lifestyle coaching? * How is the medication dosed in daily practice? Researchers will use data from electronic health records of patients in multiple outpatient locations of the Dutch Obesity Clinic (NOK, Nederlandse Obesitas Kliniek). |
MARIA HOPMAN; | 2026-03-31 |
| 3 | General Anaesthesia Vs Spinal Anaesthesia: Patient Outcomes and Success in Outpatient Primary Total Knee and Hip Arthroplasty PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are common operations used to treat severe joint disease, most often caused by osteoarthritis. An increasing number of these procedures are now performed as outpatient surgery, meaning that patients can go home on the same day as the operation. This can be beneficial for both patients and healthcare systems, … |
REGION ÖREBRO COUNTY | 2026-01-12 |
| 4 | A Randomized, Placebo- and Active Drug-Controlled, Double-Blind, Multicenter, Parallel-Group Phase II Clinical Trial to Evaluate The Efficacy and Safety of TQH3906 Capsules in The Treatment of Active Psoriatic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a marketing-oriented clinical trial of TQH3906 Capsules. A total of 156 participants are planned to be enrolled, aiming to evaluate the dose-effect relationship of TQH3906 versus placebo in the treatment of active Psoriatic Arthritis (PsA) at Week 12, with the proportion of participants achieving an American College of Rheumatology 20% (ACR20) Improvement Criteria (ACR20) response at Week 12 as the primary endpoint. |
CHIA TAI TIANQING PHARMACEUTICAL GROUP NANJING SHUNXIN PHARMACEUTICAL | 2026-02-12 |
| 5 | Comprehensive Evaluation of Scoliosis and Its Association With Functional Status, Postural Alignment, and Disease Activity in Children With Juvenile Idiopathic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may affect musculoskeletal development and posture in children. Spinal involvement, including scoliosis, is not routinely evaluated in clinical practice despite its potential impact on functional status and quality of life. This cross-sectional study aims to assess the presence of scoliosis in children with JIA and to investigate its association with functional status, postural alignment, and disease activity. Clinical and functional parameters will be analyzed to better understand the impact of spinal deformities in this population. |
BENGISU MENENTOĞLU; | 2026-02-27 |
| 6 | Efficacy of Structured Progressive Training Exercise on Muscle Strength of Patients With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to find out if a specific exercise program helps patients with Rheumatoid Arthritis (RA). RA is a chronic autoimmune disease that causes pain, weakness, and reduced function in the joints and muscles. While medication is common, exercise is also important for management. The study will test a program called Progressive Resistance Training. About 118 adult patients with RA at AL-Najaf Teaching Hospital will participate. They will be divided into two groups. One group will perform specific resistance exercises for six weeks, … |
MOHAMMED HAKIM SHAMRAN AL-HCHAIM; | 2026-04-01 |
| 7 | The Effect of Lavender Aromatherapy Massage on Pain Intensity and Wrist Joint Mobility in Patients With Rheumatoid Arthritis: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial aims to evaluate the effect of lavender aromatherapy massage on pain intensity and wrist joint mobility in patients with rheumatoid arthritis. Participants will be randomly assigned to receive lavender aromatherapy massage in addition to standard care or standard care alone. Pain intensity and wrist mobility will be measured before and after the intervention period. The findings of this study may provide evidence regarding the effectiveness of complementary therapies in reducing pain and improving joint function in patients with rheumatoid arthritis. |
ETHAR HAIDER FADHIL; | 2026-03-10 |
| 8 | TNFAIP3 Gene Expression in Ankylosing Spondylitis and Psoriatic Arthritis Patients and Its Relation to Disease Activity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. Identify gene expression of TNFAIP3 in ankylosing spondylitis and psoriatic arthritis patients. 2. Detect relation between TNFAIP3 and disease activity. Inclusion criteria: 1. Patients diagnosed with ankylosing spondylitis according to Modified New York classification criteria 1984 (10). 2. Patients diagnosed with psoriatic arthritis (PsA patients (age ≥18 years) who fulfilled the CASPAR classification criteria for PsA 2010) (11). b. Exclusion criteria: Patients with erythrodermic or pustular psoriasis, pregnant and lactating females, patients with autoimmune diseases e.g. systemic lupus erythematosus, or major systemic diseases, and patients receiving any immunosuppressive drug will be excluded from the study. |
ASMAA HASSAN MOHAMED ABDEL MAWJOUD; | 2026-04-02 |
| 9 | A Comparison of Clinical Efficacy of Mytocel MSK With AMT and PRP Injections in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Osteoarthritis is the most common joint disease, frequently affecting the knee joint. As the cartilage within the joint wears down, the balance between degeneration and regeneration is gradually disrupted, causing pain during joint movement. Mytocel MSK with AMT (Autologous Micrograft Technology) is an autologous micrograft technology, the first biocompatible solution that can be directly implanted into the joint using the patient’s own tissue. It possesses regenerative repair and pain-relieving effects, rapidly improving joint health and alleviating pain and stiffness. It is primarily applied to the musculoskeletal system; … |
CHUNG YUH TZENG; | 2026-03-06 |
| 10 | Effects of Tecar Therapy (Targeted Radiofrequency Therapy) on Pain, Physical Function, and Physical Capacity in Patients With Chronic Knee Osteoarthritis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aimed to investigate the effects of Tecar therapy on pain, physical function, and physical capacity in patients with chronic knee osteoarthritis. |
NAZIFE KAPAN; | 2026-03-02 |
| 11 | Change in LPS With Inulin Supplementation and Its Association With Knee Pain Among Older Adults With Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will test whether inulin, a type of dietary fiber, can reduce inflammation in older adults with knee osteoarthritis. Inflammation in the body may contribute to both joint pain and the progression of osteoarthritis. Inulin is a prebiotic fiber that may improve gut health and reduce lipopolysaccharide (LPS), a marker of bacterial products in the blood that is linked to inflammation. In this trial, participants with knee osteoarthritis will be randomly assigned to receive either inulin or a placebo (maltodextrin) for 8 weeks. The study will measure changes in blood LPS levels, knee pain, … |
EVELYN HSIEH DONROE; | 2025-09-24 |
| 12 | Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoarthritis. (KOA PRP ACS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The effects of single dose injection of platelet rich plasma or conditioned serum in the knee joint in patients with knee osteoarthritis will be compared |
GULIN FINDIKOGLU; | 2026-03-19 |
| 13 | Multimodal Prehabilitation of Frail Patients 70 Years and Older Undergoing Elective Knee or Hip Replacement: A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Frailty is a geriatric syndrome of reduced physiologic reserve that increases surgical risk and is common among older adults undergoing hip or knee replacement. While prehabilitation has shown promise in enhancing outcomes, … |
MARTIN INGI SIGURDSSON; | 2026-03-11 |
| 14 | Synovial Tissue As A Biomarker in The Early Management of Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Osteoarthritis is a common disease whose prevalence continues to increase. To date, there is no medical treatment that has proven effective, and only symptomatic treatments exist, mainly to reduce pain. Arthroplasty, a costly and invasive surgical procedure, is often unavoidable in advanced stages of the disease. More than just a degenerative disease of the cartilage, osteoarthritis is now recognised as a heterogeneous disease causing multi-tissue damage of varying intensity. Synovitis plays a particularly important role in the onset and progression of osteoarthritis and has been closely correlated with radiographic severity, … |
NANTES UNIVERSITY HOSPITAL | 2026-03-16 |
| 15 | Effects of Photobiomodulation and Topical Diclofenac on Inflammation and Pain in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the effects of combined treatments-dual-wavelength photobiomodulation (PBM) with or without topical diclofenac-on inflammation, pain, and joint function in patients with knee osteoarthritis (OA). It also seeks to determine the synergistic effect of PBM plus topical diclofenac on inflammatory markers, pain scores, and functional outcomes. |
MARGARETE C RIBEIRO-DASILVA; | 2026-02-27 |
| 16 | Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing After Total Knee Arthroplasty (TKA) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Recruiting will be performed via checking the calendar for scheduled TKA procedures in the \> 8 weeks by clinical staff in the UAMS orthopedic clinic. Clinic staff will look for basic inclusion/exclusion criteria in the EMR for those patients. Clinic staff will either contact directly or send contact information to the PI of this study to contact for recruitment purposes. During the initial phone call, … |
UNIVERSITY OF ARKANSAS | 2026-04-03 |
| 17 | Evaluation of The Effects of Aerobic Exercise Therapy on Quality of Life, Functional Capacity, Mood, Fatigue, and Inflammatory Markers in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effects of aerobic exercise therapy on quality of life, functional capacity, mood, and fatigue in patients with rheumatoid arthritis. Additionally, the study investigates the impact of aerobic exercise on inflammatory markers, pain, and disease activity. |
FATIMA YAMAN; | 2026-04-01 |
| 18 | Prevention of Recurrence of Herpes Simplex in Patients With Autoimmune Rheumatic Diseases PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized, double-blind, placebo-controlled clinical trial is to evaluate the effectiveness and safety of oral suppressive therapy with acyclovir in preventing herpes simplex virus (HSV) reactivation in patients with autoimmune rheumatic diseases (ARDs) who have a history of recurrent HS episodes. The main questions this study aims to answer are: Does continuous oral acyclovir reduce the frequency of HSV reactivation in ARD patients compared to placebo? What is the safety profile of prolonged acyclovir use in this population? What are the main risk factors (clinical and treatment-related) associated with HSV reactivation in immunosuppressed patients. Participants will: Be randomly assigned (1:1) to receive oral acyclovir (400 mg BID) or placebo for 12 months; Be followed for a total of 24 months, with regular clinical evaluations (every 3 months) and laboratory monitoring (every 3 months); Be assessed for HSV recurrence based on clinical symptoms, detection of HSV DNA by polymerase chain reaction (PCR) in mucocutaneous swabs in doubtful cases, and standardized reporting forms; Undergo disease activity assessments and adverse event monitoring at regular intervals. The study includes adult and pediatric patients with confirmed diagnoses of one of the following ARDs: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), dermatomyositis/polymyositis (DM/PM), systemic sclerosis (SSc), systemic vasculitis, primary Sjögren’s syndrome, Mixed connective tissue disease (MCTD), Chronic recurrent multifocal osteomyelitis (CRMO), Sarcoidosis and Behçet’s Syndrome. All participants must have a documented history of recurrent HSV (oral and/or genital) before inclusion. |
UNIVERSITY OF SAO PAULO GENERAL HOSPITAL | 2026-03-05 |
| 19 | Evaluation of The Efficacy of Corticosteroids in Septic Arthritis in Adults: Randomized Double-blind Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Septic arthritis is a severe infection associated with significant morbidity and mortality. Despite eradication of the microorganisms, persistent inflammation may lead to substantial long-term functional joint sequelae. The use of corticosteroids could reduce this inflammation, thereby improving functional joint outcomes and facilitating first-line medical treatment. The hypothesis of this study is that corticosteroid administration, in addition to antibiotic therapy, reduces persistent inflammation and improves functional joint prognosis in adult patients with acute septic arthritis. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2026-02-27 |
| 20 | Understanding of Rare Inflammatory Arthritis in Comparison to Classical Inflammatory Arthritis : Tissular Observations and Immune Infiltrate Characterization : The UTOPIC Project PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The pathophysiology of certain inflammatory arthritides remains poorly understood, particularly when associated with rare systemic autoimmune diseases such as systemic sclerosis (SSc), or when emerging in the context of immune-related adverse events from cancer immunotherapies. These immunotherapy-induced arthritides represent a new and increasingly encountered clinical entity in rheumatology. A deeper understanding of the mechanisms underlying joint inflammation in these settings is essential for identifying specific therapeutic targets, especially given the limitations of current treatment options and the risks associated with broad immunosuppressive strategies such as prolonged corticosteroid use, … |
UNIVERSITY HOSPITAL BREST | 2026-04-03 |
| 21 | A Multicenter, Randomized, Double-Blind, Double-Dummy, Active-Controlled Phase II Clinical Study to Evaluate The Efficacy, Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Punarlimab in Subjects With Acute Gouty Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multi center,randomized,double-blind,double-dummy,active-controlled study,and planned enrollment of 120-170 subjects,an interim analysis will be conducted after first 60 subjects complete the 72 -hour pain Visual Analogue Scale(VAS) assessment following their initial dose.Based on the analysis result，the sample size may be adjusted, and 1or 2 group(s）of the investigational drug will be selected to continue enrollment along with the active comparator group.The goal is to evaluate the efficacy of plonmarlimab in subjects with acute gouty arthristis. |
TJ BIOPHARMA | 2026-04-03 |
| 22 | The Effect of Venlafaxine As An Adjunct Therapy on The Clinical Outcome of Rheumatoid Arthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation of the joints, leading to pain, swelling, disability, and reduced quality of life. Current therapies, although effective, may have limited efficacy or tolerability in some patients. Biological DMARDs are often associated with adverse effects, including increased risk of serious infections and heart failure. Long-term use may also increase the risk of malignancies. These limitations, together with their high cost. Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), … |
SARA AHMED IBRAHIM AHMED; | 2026-03-27 |
| 23 | Effect of Methotrexate Discontinuation on Immunogenicity of 20-valent Pneumococcal Conjugate Vaccine (PCV20) in Patients With Autoimmune Rheumatic Diseases PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to evaluate the effect of temporary methotrexate (MTX) discontinuation on the humoral immunogenicity of the 20-valent pneumococcal conjugate vaccine (PCV20) in adult patients with autoimmune rheumatic diseases (ARDs). Key questions: * Does suspending MTX for 2 weeks after PCV20 enhance humoral immunogenicity? * What is the impact of MTX discontinuation on functional opsonophagocytic activity (OPA) and cellular immunity? * What is the risk of disease flaring with MTX withdrawal? |
UNIVERSITY OF SAO PAULO GENERAL HOSPITAL | 2026-03-24 |
| 24 | Efficacy and Safety of A Single-Dose Hyaluronic Acid Injection in Adults With Symptomatic Knee Osteoarthritis: A Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: HA therapy typically consists of several intra-articular injections administered at weekly intervals. A single-dose IA-HA treatment offers patients and physicians a treatment option that involves both lower costs and fewer clinic visits. Furthermore, considering the administration procedure, we believe that single-dose therapy helps reduce the risk of potential side effects. In light of this information, our study aims to retrospectively evaluate the efficacy and safety of HA in patients with symptomatic knee OA who have received a single-dose intra-articular HA injection. |
YUNUS EMRE DOĞAN; | 2026-03-23 |
| 25 | Surgeon Physiologic Stress During Unicompartmental Knee Arthroplasty: Manual Vs Computer-Assisted Technique PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the physiologic stress experienced by the surgeon during unicompartmental knee arthroplasty (UKA) performed using a manual technique versus a computer-assisted technique. Surgeon physiologic parameters, including energy expenditure, heart rate, heart rate variability, and minute ventilation, will be measured intraoperatively using a wearable monitoring device (Hexoskin). The study seeks to determine whether computer-assisted surgery influences surgeon workload compared to the conventional manual approach. |
JACOPO CONTEDUCA; | 2026-03-27 |
| 26 | Shock Wave Versus Traditional Physical Therapy for Adult Chronic Knee Osteoarthritis: A Prospective Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the effectiveness of extracorporeal shock wave therapy (ESWT) versus structured therapeutic exercise in patients with chronic knee osteoarthritis (KOA), with respect to pain reduction and improvement of knee function. |
MAGDY MOHAMED ALY SHABANA; | 2026-03-19 |
| 27 | Single-Center, Randomized, Double-Blind, Parallel-Controlled Clinical Trial to Evaluate The Efficacy and Safety of ALT001 for Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial will focus on the core efficacy endpoints including relief of pain intensity, improvement of joint motor function and enhancement of quality of life in patients. Meanwhile, it will strictly monitor key safety indicators such as the occurrence of various adverse events after medication, the severity and duration of adverse reactions, and conduct a multi-dimensional and multi-level comprehensive assessment. The study aims to clarify the clinical benefit profile and safety risks of the investigational product ALT001, and provide scientific, … |
UNION HOSPITAL TONGJI MEDICAL COLLEGE HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY | 2026-03-24 |
| 28 | Methotrexate Versus TNF Inhibition in Preventing Structural Damage in Early Psoriatic Arthritis: A Randomized Trial Using HR-pQCT (MeTEPsA Trial) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Investigators hypothesize that TNFi is superior to SC MTX in preventing structural damage in early, treatment-naïve PsA, assessed using HR-pQCT. The study aims to ascertain: \- The effect of SC MTX and TNFi (adalimumab biosimilar) on erosion and enthesiophyte progression in early PsA by HR-pQCT. Participants will be: * Randomized in a 1:1 ratio to either the SC MTX group or the TNFi group. * HR-pQCT of MCPJ 2-4 will be performed at baseline, week 24, … |
LAI-SHAN TAM; | 2026-03-23 |
| 29 | Application of The Personalized N-of-1 Trial Design in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this N-of-1 study is to learn about treatment for individual patients who have rheumatoid arthritis (RA,) for which many treatments are available. The treatments are different in how they work, the way they are given, side- effects, and cost. While treatment guidelines are available, … |
HARRY P SELKER; | 2026-02-19 |
| 30 | Impact of Whole-body Vibration Training (WBVT) on The Elderly With Combined Bilateral Knee Osteoarthritis (KOA) and Sarcopenic Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will aim to evaluate the effects of whole-body vibration training (WBVT) on body composition, muscle strength (hand grip strength), and physical performance \[gait speed (GS), 5-time chair stand test (5CST), and short physical performance battery (SPPB), pain intensity, triglycerides in older people with knee OA and sarcopenic obesity in a group of Men compared to group of females. |
MARIAM ABDEL RAHMAN; | 2026-03-18 |
| 31 | Randomized, Prospective, Double Blind, Multi-Center, Phase 3 Pivotal Clinical Trial to Compare Efficacy and Safety of CARTISTEM® and Surgical Comparator in Subjects With Knee Cartilage Lesions and Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To establish the efficacy and safety of CARTISTEM®, a combination product composed of allogeneic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) formulated with a cross-linked sodium hyaluronate (HA) hydrogel, CARTISTEM® compared to the surgical comparator of debridement in Subjects with knee cartilage lesions and osteoarthritis. This trial is intended to provide evidence of the superiority of CARTISTEM® to reduce knee pain and improve knee function compared to debridement for Subjects with knee cartilage lesions and osteoarthritis at 2-years post-treatment. Additionally, … |
JEFFERY DAVIS; | 2026-04-01 |
| 32 | A Multicenter, Randomized, Double-blind, Agent-positive and Placebo-controlled, Parallel-group Phase Ib Study to Evaluate The Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Primary Objective: To explore the effectiveness of different doses of HRS-2129 in the treatment of patients with moderate to severe pain in knee osteoarthritis. Secondary Objectives: To evaluate the safety of different doses of HRS-2129 for the treatment of patients with moderate to severe pain in knee osteoarthritis; To evaluate the population pharmacokinetic profile of HRS-2129 in patients with knee osteoarthritis. |
QING JIANG; | 2026-03-19 |
| 33 | NPS-LDA – New Care Pathway Using Automated Dynamic Laximetry PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Today, in the event of a knee sprain with suspected cruciate ligament damage, magnetic resonance imaging (MRI) is generally prescribed to confirm or refute the diagnosis and assess its severity. Once the MRI has been performed, the patient’s care is organized by the doctor of his or her choice, depending on the diagnosis. Previous studies have shown that Automated Dynamic Laximetry (ADL) performs identically to MRI in helping to diagnose a knee sprain as a complementary examination and in assessing its severity. Performing LDA at the start of the patient’s care pathway, … |
UNIVERSITY HOSPITAL ANGERS | 2026-03-13 |
| 34 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase III Clinical Study to Evaluate The Efficacy and Safety of 608 in Patients With Non-radiographic Axial Spondyloarthritis (Nr-axSpA) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will evaluate the efficacy and safety of 608 in patients with nr-axSpA. |
XIAOFENG ZENG; | 2026-01-16 |
| 35 | A Phase 1a, Open-Label, First-in-Human Study to Investigate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of KT501 By A Single Subcutaneous Administration in Participants With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 1, open-label, first-in-human study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of KT501 administered subcutaneously to participants with Rheumatoid Arthritis (RA). |
KALI THERAPEUTICS | 2026-03-10 |
| 36 | A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial Evaluating The Efficacy and Safety of QLS12010 Capsules in Adult Participants With Moderate-to-Severe Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this randomized, double-blind, placebo-controlled phase II clinical trial is to investigate the safety and efficacy of QLS12010 in subjects with moderate-to-severe rheumatoid arthritis.The main questions it aims to answer are: • Efficacy and safety of QLS12010 in participants with rheumatoid arthritis. Participants will be randomly allocated to four treatment groups at a 1:1:1:1 ratio to compare the efficacy and safety of different dosages of QLS12010 Capsules against the placebo. |
QILU PHARMACEUTICAL | 2026-02-02 |
| 37 | Kinesiophobia in Rheumatoid Arthritis: Associations With Functional Disability, Disease Activity, and Related Clinical Factors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Objectives: Impairment of physical function is a core feature of RA, particularly in patients with high disease activity where pain and inflammation directly limit movement. but, Reduced mobility in RA is not exclusively driven by inflammatory pathology. There are non-inflammatory factors, including kinesiophobia, fatigue, depression, and anxiety, may significantly contribute to functional limitation and may initiate a self-perpetuating cycle in which movement avoidance leads to physical deconditioning, muscle weakness, and progressive functional decline. The aim of this study is to examine the relationship between kinesiophobia and functional outcomes in patients with rheumatoid arthritis, … |
MARWA ABDELHAKIM SHABAN MAGHLOUF; | 2026-03-03 |
| 38 | The Effect of A Novel Joint Distraction Knee Orthosis for Treating Medial Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Abstract: Scored 0 to 100, where 0 represents total knee disability and 100 represents perfect knee 0 to 1, where 1 is perfect health 0-100, zero meaning no pain, 10 meaning severe pain 6 … |
ICARUS MEDICAL INNOVATIONS | 2026-02-27 |
| 39 | Effectiveness and Safety of The TOUCH® CMC 1 Prosthesis, Post-Approval Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to meet a PMA (P240020) condition of approval of the TOUCH® CMC 1 Prosthesis to evaluate the effectiveness and safety of the prosthesis in the United States (US) population. The device performance in newly enrolled US patients implanted by US surgeons will be compared to device performance observed within the outside the US (OUS) premarket cohort. |
KERI MEDICAL SA | 2026-02-12 |
| 40 | A Randomized, Double-blind Study Evaluating The Effectiveness of Two Different Doses of MyCondroTM on Physical Mobility and Joint Health Using Participant-Reported Outcomes in Individuals With Self-Reported Mobility Issues Associated With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the effect of two different doses of a consumer-grade product, MyCondro™, on individuals experiencing mobility issues related to knee osteoarthritis. The primary goal is to measure improvements in overall joint health and mobility by tracking changes in participants’ total WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) scores from the beginning to the end of the trial. Additionally, the study aims to assess secondary outcomes, including the product’s impact on pain, stiffness, knee function, patient-reported improvement, inflammatory blood markers (CRP), and daily physical activity. |
NOAH CRAFT; | 2026-03-25 |
| 41 | Efficacy of A Self-Management Smartphone App in Promoting Safety Skills of Patients With Inflammatory Arthritis Treated By Anti-Rheumatic Drugs PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including psoriatic arthritis (PsA), are chronic painful diseases that impair quality of life. Disease-modifying antirheumatic drugs (DMARDs) are used to control disease activity, reduce functional disability, and improve prognosis. These include conventional DMARDs such as methotrexate, as well as targeted DMARDs (tDMARDs), i.e., biological agents (bDMARDs) like anti-TNF alpha and JAK inhibitors. Patients treated with tDMARDs face a risk of adverse effects, including an increased risk of infections. Therapeutic patient education has been shown to help patients develop safety skills, … |
CATHERINE BEAUVAIS; | 2026-03-13 |
| 42 | Circulating Fibroblast Activation Protein (FAP) As A Marker for Fibroblast-Driven Pathology in Rheumatoid Arthritis and Systemic Sclerosis : Implication for Joint, Skin and Lung Fibrosis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to measure a blood protein called fibroblast activation protein (FAP), which is linked to tissue scarring and inflammation. A small blood sample will be taken from participants (RA , SSc patients and healthy people ), and the FAP level will be measured and compared with routine clinical examinations, imaging studies, … |
TOQA MAHFOUZ MOHAMED AHMED; | 2026-02-06 |
| 43 | Long-term Follow-up of Patients Undergoing Aseptic Revision Hip Arthroplasty or Complex Primary Hip Arthroplasty Treated at University Hospitals Leuven PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Total hip arthroplasty (THA) volumes continue to rise each year as the population ages and indications broaden. Increasingly, younger patients require hip replacement for conditions beyond primary osteoarthritis or fractures. As a result, the number of revision procedures is growing and is expected to increase further. Prospective data collection within this population will enable us to address key uncertainties, particularly around optimal implant selection for complex primary and revision cases. In addition, establishing a structured prospective database will allow for systematic internal auditing for quality assurance. Even simple metrics – … |
STIJN GHIJSELINGS; | 2026-03-23 |
| 44 | A Randomised Control Trial of The Use of An Intraarticular Hydrogel Arthrosemid® Vs. Steroid for The Non-operative Management of Moderate to Severe Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will be a randomised control trial of the use of intra-articular Arthrosamid® a novel intraarticular hydrogel vs. standard of care (steroid and local anaesthetic) for the non-operative management of knee osteoarthritis. |
SEAN-TEE LIM; | 2026-03-27 |
| 45 | Comparison of Band Tissue Flossing Method and Traditional Cuff Method for Blood Flow Restriction Training in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to compare the effect of band tissue flossing method and traditional cuff method for blood flow restriction training on pain, range of motion, muscle strength and functional status in patients with knee osteoarthritis. Symptoms of this condition limit patient’s ability to perform high load strengthening. Blood flow restraining training allows strengthening with lower loads. 46 subjects will be divided in two groups, … |
MUHAMMAD AFFAN IQBAL; | 2026-03-17 |
| 46 | Evaluation of The Treatment of Trapeziometacarpal Osteoarthritis (TMC OA) With A Treated, Devitalized and Sterile Amniotic Membrane of Umbilical Cord Placed in Joint Interposition PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this clinical trial is to evaluate whether a human umbilical cord amniotic membrane allograft can serve as an interposition implant in the surgical treatment of trapeziometacarpal osteoarthritis. The main question this study aims to address is : \- Can interposition of a human umbilical cord amniotic membrane within the trapeziometacarpal joint reduces postoperative pain and improves thumb mobility, grip and pinch strength, … |
TBF GENIE TISSULAIRE | 2026-02-27 |
| 47 | Test-Retest Reliability of A Submaximal Exercise Test in Patients With Hip- And/or Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim is to evaluate the test-retest reliability of the primary care-adapted Ekblom-Bak submaximal ergometer bicycle test in patients with hip- and/or knee osteoarthritis (OA). Forty patients with hip- and/or knee OA eligible for the Swedish national OA treatment program in primary care are to be recruited. After screening for contraindications, participants will perform the aEB-test twice within 1-2 weeks. The investigators hypothezise that the test will demonstrate acceptable test-retest reliability in patients with hip- … |
VASTRA GOTALAND REGION | 2026-02-06 |
| 48 | Evaluation of CCR6 Gene Expression and Circulating CCL20 Levels As Potential Biomarkers in Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Rheumatoid arthritis (RA) is characterized as a systemic auto immune disorder linked to a persistent inflammatory process that can harm both joints and extra articular organs. The upregulation of the CCR6/CCL20 axis in the synovial tissues and salivary glands (in cases of secondary Sjögren’s syndrome) is considered to contribute to the recruitment of Th17 cells, which in turn enhances IL 17A production and promotes the inflammatory cycle. |
SALMA KHALAF ABDELMAGEED; | 2026-02-09 |
| 49 | Integrating Trunk Stabilization Exercises With Conventional Rehabilitation Protocol for Osteoarthritis in Patients With Knee-Spine Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation in patients with knee-spine syndrome. It further examines whether improving trunk stability can reduce knee pain and enhance functional outcomes in knee osteoarthritis |
SUMAN SHERAZ; | 2026-03-20 |
| 50 | A Randomized, Double-Blind, Two-Control Clinical Study of Knee Pain Ejiao Paste in The Treatment of Knee Osteoarthritis (Qi and Blood Deficiency Pattern) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To explore the analgesic efficacy of Knee Pain Ejiao Paste in the treatment of knee osteoarthritis (Qi and Blood Deficiency Pattern) after 12 weeks, using an Ejiao-free clear paste as a parallel control and incorporating a synthetic external control. |
YUELONG CAO; | 2026-04-01 |
| 51 | Evaluation of The Relation Between Serum Interleukins 17, 38, 41, and HLA-B27 Gene Expression in Ankylosing Spondylitis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to measure the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group. The main question it aims to answer is: Does the disease activity, severity, serum level of cytokines (IL-17, IL-38, and IL-41) are affected by the HLA-b27 gene positivity? Researchers will compare the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group to see if there significant differences in serum levels of interleukins 17, 38, … |
ALAA EZAT AHMED; | 2026-02-09 |
| 52 | Effect of Metformin Iontophoresis Combined With Physical Therapy Rehabilitation on Knee Osteoarthritis in Postmenopausal Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed as a randomized, double-blind, placebo-controlled clinical trial with two parallel groups. All participants will receive a standardized physical therapy rehabilitation program. Participants will be randomly allocated into either a study group receiving metformin iontophoresis or a control group receiving placebo iontophoresis. Both participants and outcome assessors will be blinded to group allocation. |
EMAN SAID SAWAN; | 2026-02-09 |
| 53 | Ketogenic Diet to Reduce Osteoarthritis Pain in MCI PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Osteoarthritis and mild cognitive impairment are common conditions that share underlying biological processes related to metabolism and inflammation. This study will examine whether a well-formulated ketogenic diet influences pain, physical function, and cognitive outcomes in adults with osteoarthritis and mild cognitive impairment. Participants will follow a supervised ketogenic dietary intervention, with assessments conducted before and after the intervention to evaluate changes in symptoms and related biological markers. The goal of this study is to better understand shared mechanisms between joint pain and cognitive health and to explore whether a ketogenic dietary approach may support symptom management in these populations. |
DOUG WRIGHT; | 2026-02-18 |
| 54 | Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis: A Case-Control Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Knee osteoarthritis (OA) is a degenerative joint disease characterized by pain, muscle weakness, and functional limitations that significantly affect lower limb muscle performance. Structural and physiological alterations in the quadriceps muscle, particularly in the vastus medialis obliquus (VMO), have been reported in individuals with knee OA, including reductions in muscle cross-sectional area, intramuscular fat infiltration, vascular changes, and impaired neuromuscular activation. Muscle oxygenation (SmO₂) is an objective indicator of the metabolic status and circulatory capacity of skeletal muscle. However, … |
AYŞEM ECEM ÖZDEMIR; | 2026-03-17 |
| 55 | A Study on The Clinical Efficacy and Safety of Telitacicept Combined With Baricitinib in The Treatment of Difficult-to-Treat Rheumatoid Arthritis (D2T RA) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to observe the clinical efficacy and safety of telitacicept combined with baricitinib in the treatment of D2TRA patients |
ZHENHUA YING; | 2026-03-30 |
| 56 | Assessing The Association Between WBCT PFJ Morphological Metrics and Knee Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Patellofemoral joint (PFJ) pain is a common, often chronic, aching pain behind or around the kneecap, frequently called runner’s knee. It occurs when the kneecap does not glide smoothly over the thigh bone, often due to muscle weakness or overuse. It makes sitting for long periods, climbing stairs, or kneeling painful. Symptomatic knee osteoarthritis (OA) is a common, long-term condition where the protective cartilage in the knee joint wears away, causing the bones to rub together, leading to daily pain and stiffness. In simple terms, it is a wear-and-tear disease of the entire joint that makes walking, climbing stairs, … |
NEIL SEGAL; | 2026-03-16 |
| 57 | Rewiring The Brain-Immune Axis for Chronic Pain Using Transcranial Magnetic Stimulation in Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Despite advances in immunomodulatory therapies, many Psoriatic arthritis (PsA) patients experience persistent pain unrelated to clinical active joint inflammation. Recent evidence suggests the Inferior Parietal Lobule (IPL) serves as a neuroimmune hub linking central neural activity with peripheral immune dysregulation. In a prior feasibility study, a single L-IPL-targeted TMS session reduced pain and altered immune signalling in inflammatory arthritis by reducing STAT3 phosphorylation in circulating monocytes. This study builds on those findings by evaluating whether rTMS over 4 weeks can induce sustained immune reprogramming while providing meaningful pain relief. |
FLAVIA SUNZINI; | 2026-02-11 |
| 58 | Pilot Exploration of Platelet Characterization of Platelet Rich Plasma Created By Two Different Systems PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators would like to study the differences in the quality of Platelet Rich Plasma (PRP) between two different machines in those with knee osteoarthritis. Knee osteoarthritis means your cartilage has been worn down, and it affects your knee joint. Both machines, the APEX Biologix XCELL PRP System and the Emcyte PurePRP Supraphysiologic Concentrating System, are FDA approved, commercially available, and makes PRP. The investigators will check if the platelets in the PRP have different amounts or work differently. The investigators will also assess participants symptoms after the injection and compare the two different preparation systems. |
ANTHONY LUKE; | 2026-03-24 |
| 59 | Comparison of Aquatic and Land-Based Mulligan Mobilization With Movement on Pain, and Function in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the effects of aquatic and land-based Mulligan mobilization with movement in individuals with knee osteoarthritis, with particular focus on their impact on pain and functional outcomes. |
SUMAN SHERAZ; | 2026-03-20 |
| 60 | Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (Thumbs-up Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether platelet-rich plasma (PRP) injections improve pain and function in adults with thumb base osteoarthritis (CMC-I OA). The main questions it aims to answer are: Does a PRP injection reduce pain compared to a placebo (saline) injection? Does PRP improve hand function, strength, … |
EVI LOOS; | 2026-03-27 |
| 61 | A Prospective, Multi-Center Post-Market Clinical Study Evaluating The Safety, Performance, and Clinical Benefits of The Persona® SoluTion® PPS Femur PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to generate clinical evidence and evaluate the safety and performance of the Persona® SoluTion® PPS Femurs in the US market, with data supporting global regulatory submissions, … |
ZIMMER BIOMET | 2026-02-27 |
| 62 | A 2-Part, Phase 1b Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986454 in Participants With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety, tolerability, and drug levels of BMS-986454 in participants with Rheumatoid Arthritis |
BRISTOL MYERS SQUIBB | 2026-02-04 |
| 63 | Comparison of Close Chain and Open Chain Exercises With Blood Flow Restriction in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this research is to find and compare the effect of close chain and open chain exercises with blood flow restriction in knee osteoarthritis on pain, range of motion, strength and functional performance in patients with knee osteoarthritis. Randomized controlled trials done at Railway General Hospital and Medistic Medical and Dental Center, Rawalpindi. The sample size was 40. The subjects were divided in two groups, … |
MUHAMMAD AFFAN IQBAL; | 2026-02-23 |
| 64 | Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a trial to find out how weight loss (achieved by the use of tirzepatide) or ixekizumab treatment affects the characteristics of skin, joint and fat tissues in patients with Psoriatic Arthritis, Psoriasis and obesity/overweight BMI \>=27. Participants will be allocated either Tirzepatide, Ixekizumab or both. Samples of joint tissue, fat and skin will be taken at the start of the study and week 12. Blood and urine samples will also be taken. The primary objective will be to assess the changes seen in the joint, … |
CARL GOODYEAR; | 2026-03-02 |
| 65 | Efficacy of Aerobic Exercise Versus Therapeutic Exercises on Exercise-induced Hypoalgesia in Knee Osteoarthritis. Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study compares two exercise strategies in people with knee osteoarthritis. The first is aerobic exercise on a recumbent cycle ergometer, with effort controlled by the Borg scale. The second is a therapeutic exercise program with resistance, neuromuscular, mobility, and balance components. The primary objective is to determine which approach produces greater exercise induced hypoalgesia, measured by the increase in pressure pain threshold at the knee within the session across four anchor sessions during a ten week program. This is a randomized clinical trial with two parallel arms. Ninety participants, between forty five and seventy five years of age, … |
CID GOMES; | 2026-04-02 |
| 66 | Exploring Perspectives on Palliative and Supportive Care, to Inform Recommendations to Help People Live Well With Inflammatory Arthritis Throughout The Disease Course (ENRICH) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Palliative Care (PC) focuses on maximising quality of life and care for patients and their families in the last 1000 days of life. Supportive Care (SC) is provided earlier in life for people with a long-term health condition. People living with inflammatory arthritis, (such as rheumatoid arthritis) can experience ongoing pain, stiffness, limitations in their joints, and intrusive fatigue. This impacts daily living activities and emotional well-being. People with inflammatory arthritis would value support to manage symptoms across the course of their disease. They would like PC healthcare professionals (HCPs) to understand their conditions better, … |
DOROTHY HOUSE HOSPICE | 2026-03-25 |
| 67 | A Dose Escalation Clinical Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK-1045 in Participants With Systemic Lupus Erythematosus and Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study looks at a study medicine called MK-1045 in people with lupus and rheumatoid arthritis (RA). The main goal of the study is to learn about the safety of MK-1045 and if people tolerate it when they receive it at different dose levels (amounts). |
MERCK SHARP & DOHME | 2026-04-01 |
| 68 | Effects of Lower Body Positive Pressure Therapy Versus Alpha Lipoic Acid and Omega-3 Fatty Acids on Pain, Function, and Inflammation in Overweight Women With Knee Osteoarthritis: A Randomized Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Here is a \*\*concise, clear summary (\~250 words / well under 5000 characters)\*\* while preserving the key scientific points: \— Knee osteoarthritis (KOA) is highly prevalent among overweight women, affecting more than 30% of those with BMI ≥25 kg/m². Excess body weight increases knee joint loading by 4-6 times per additional kilogram, accelerating cartilage degeneration, subchondral bone changes, and synovial inflammation. These alterations result in chronic pain, stiffness, functional limitation, and reduced quality of life, with obesity-related metabolic inflammation further worsening disease progression. Standard physical therapy (PT) remains first-line treatment, yet provides only modest benefits, … |
EMAN SAID SAWAN; | 2026-02-10 |
| 69 | Double-blind, Randomized Controlled Pilot Study to Assess The Effect of Pulsed Electromagnetic Field on Inflammatory Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will assess the efficacy of pulsed electromagnetic field therapy in patients with inflammatory knee osteoarthritis confirmed by MRI-detected effusion-synovitis. Fifty participants will be randomly allocated into two groups. One group will receive active PEMF therapy at a specific optimized parameter twice a week for 8 weeks, while the other group will receive sham treatment using the same device without PEMF signal. The primary outcome is the change in WOMAC pain score, and secondary outcomes include knee function, stiffness, quality of life, and MRI-quantified structural changes. |
THE HONG KONG POLYTECHNIC UNIVERSITY | 2026-03-02 |
| 70 | Effect of Subthreshold Stimulation on Fatigability, Lower Limb Muscle Function and Strength, and Inflammatory Blood Markers in Patients With Rheumatoid Arthritis: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study will include 2 groups. The study group will receive subthreshold stimulation, while the control group will receive sham treatment. |
AYMAN MOHAMED; | 2026-01-27 |
| 71 | The Importance of Adding Fenestration to Ultrasound-Guided Baker’s Cyst Aspiration PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate whether adding a fenestration procedure to standard ultrasound-guided aspiration and corticosteroid-lidocaine injection provides additional clinical benefits for patients with symptomatic Baker’s cyst associated with knee osteoarthritis. Baker’s cyst is a fluid-filled swelling located behind the knee that may cause pain, stiffness, swelling, and limited mobility. Although aspiration with medication injection is commonly used to relieve symptoms, recurrence of the cyst is frequent. Fenestration is a minimally invasive technique in which small controlled openings are created in the cyst wall under ultrasound guidance to improve internal drainage and potentially reduce recurrence. In this prospective, randomized, double-blind, … |
TUTKU NAZ BULUT; | 2026-02-04 |
| 72 | A Phase 1, Open-label, Dose-escalation Study (ELEVATE-1) to Evaluate The Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of A CD19/CD20 T-cell Engager in Participants With B-cell Driven Autoimmune Rheumatic Diseases (ARD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a 2-part study of GSK5926371 in participants with autoimmune rheumatic diseases (ARD). In part 1, participants will receive different doses of GSK5926371 to find a suitable priming dose. In part 2, participants will receive GSK5926371 at doses based on data from part 1. The study is aimed at testing if GSK5926371 is safe, well-tolerated, how the body processes the study drug, how it works in the body, and whether it triggers any immune responses. |
HIROAKI NIIRO; | 2026-03-17 |
| 73 | A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate The Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening. |
HARRY STUDDARD; | 2026-03-20 |
| 74 | Prediction of Dysphagia Severity and Diagnosis of Its Possible Causes in Rheumatoid Arthritis: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary goal of this cross-sectional study is to assess risk factors/predictors for dysphagia severity in RA. The secondary goals include demonstrating whether flexible fiberoptic pharyngolaryngoscopy can diagnose joint-affection-induced dysphagia in patients with rheumatoid arthritis (RA) and whether both oropharyngeal and esophageal dysphagia are present among these patients. The main questions it aims to answer are * What are the predictors that are associated with dysphagia severity via flexible fiberoptic pharyngolaryngoscopy in rheumatoid arthritis patients? * Whether flexible fiberoptic pharyngolaryngoscopy can diagnose joint-affection-induced dysphagia in patients with RA? * Whether both oropharyngeal and esophageal dysphagia are present in patients with RA? |
ALIAA MAMDOUH ABDELAZIZ FARAG; | 2026-03-09 |
| 75 | Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A randomized controlled trial will be conducted at the Department of Physiotherapy, Dr. Ziauddin Hospital and Al-Rayaz Hospital, Karachi, Pakistan. A total of 150 patients diagnosed with knee osteoarthritis, aged between 40-60 years, will be recruited through a non-probability purposive sampling technique. Written informed consent will be obtained from all eligible participants prior to enrollment. The participants will be randomly allocated by the help of computer generated randomization sheet, into two groups i.e. experimental and the control group, with 75 participants in each group. Group A (experimental group) will receive diagonal proprioceptive neuromuscular facilitation (PNF) pattern exercises, … |
RABIA HASSAN; | 2026-02-11 |
| 76 | Evaluation of The Effect of Vitamin E (α-tocopherol) Supplementation on Clinical Activity and Inflammation in Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this clinical trial is to determine whether α-tocopherol (vitamin E) supplementation decreases inflammation and clinical activity in patients with rheumatoid arthritis (RA).The main questions to be answered are: * Is supplementation with vitamin E (α-tocopherol) for one month associated with decreased clinical activity and inflammation in patients with RA? Researchers will compare α-tocopherol with a placebo (a look-alike substance containing no active ingredient) to see if α-tocopherol effectively reduces inflammation and clinical activity in patients with rheumatoid arthritis. Participants will: * Take two capsules (one in the morning and one in the afternoon) of either α-tocopherol or placebo every day for a month. * Attend clinic visits at the start of the intervention (baseline) and at the end of the month for final check-ups and tests. * Keep a diary to record your symptoms and how often you take α-tocopherol or placebo. |
CHRISTIAN JOHANA J BAÑOS HERNÁNDEZ; | 2026-02-13 |
| 77 | A Phase 1, Multicenter, Randomized, Placebo-Controlled, Participant-Blind, Single-Ascending Dose Study of LY4298445 in Healthy Participants and An Open-Label Single-Ascending Dose and Multiple-Ascending Dose Study of LY4298445 in Participants With Systemic Lupus Erythematosus or Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate the safety and tolerability of LY4298445 in healthy participants and in participants with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). Participation in the study will last up to approximately 52 weeks. |
GLORIA WONG; | 2026-03-23 |
| 78 | Hemiarthroplasty Versus Total Shoulder Arthroplasty for The Treatment of Glenohumeral Osteoarthritis: The Impact of Modern Implant Options PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multi-center study assessing postoperative outcomes associated with hemiarthroplasty with pyrocarbon (hPYC) versus anatomic total shoulder arthroplasty (aTSA). Once eligibility criteria is met, the subject will be randomized to one of the two study arms. Subjects will be followed for ten years. Clinical and patient-reported outcome measures (PROMs) will be assessed. |
BENJAMIN ZMISTOWSKI; | 2026-02-19 |
| 79 | Percutaneous Transcatheter Genicular Embolization in Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical study investigates a minimally invasive treatment called percutaneous transcatheter embolization of knee arteries for patients with chronic knee pain caused by advanced knee osteoarthritis or persistent pain after total knee replacement. Osteoarthritis of the knee is a common degenerative condition that can lead to long-term pain, reduced mobility, and decreased quality of life, and some patients do not achieve sufficient relief with standard treatments. The study is based on the hypothesis that targeted embolization of small arteries supplying the inflamed tissues of the knee can safely reduce abnormal blood flow associated with inflammation, … |
PATRIK MATRAS; | 2026-02-04 |
| 80 | Effects of Combined High-Intensity Aerobic Training and Resistance Training on Cardiovascular and Metabolic Health in Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomised controlled trial is to evaluate the effects of a 12-week intervention comprising high-intensity interval aerobic training and strength training on cardiovascular function, metabolic health profile and inflammation in patients with Psoriatic arthritis. A secondary goal is to assess the intervention´s impact on physical fitness, pain, fatigue, and health-related quality of life, and to explore long-term maintenance of exercise following completion of the intervention. We hypothesize that 12 weeks of combined high-intensity interval aerobic training and strength training will improve cardiometabolic health, inflammation, and enhance physical fitness, fatigue, pain and quality of life in Psoriatic arthritis. |
ANNELIE BILBERG; | 2026-01-22 |
| 81 | Phase IIb Clinical Study to Assess The Efficacy and Safety of GenSci120 Injection in Patients With Moderately to Severely Active Rheumatoid Arthritis Who Have An Inadequate Response to at Least One Disease-modifying Antirheumatic Drug PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, double-blind, parallel, placebo- and active comparator- controlled clinical study conducted in patients with moderately to severely active RA and an inadequate response to at least one DMARD, designed to assess the efficacy and safety of GenSci120 injection in this patient population. The study consists of a screening period (≤ 4 weeks), a placebo-controlled treatment period (14 weeks), an extension treatment period (14 weeks), and a follow-up period (10 weeks), with a total of 17 scheduled visits. |
CHANGCHUN GENESCIENCE PHARMACEUTICAL | 2026-02-20 |
| 82 | Association of GLP1 Analogues and SGLT2 Inhibitors With The Risk of Osteoarthritis in Type 2 Diabetic Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Assessing the effects of GLP1 RA Vs SGLT2 Inhibitors vs. Standard of care in joint pain, physical function, stiffness, and improving Quality of Life for patients with type 2 diabetes. |
ASMAA ABDELFATTAH ELSAYED; | 2026-01-22 |
| 83 | The Validity, Reliability, and Clinical Correlation Study of The OMERACT Knee Osteoarthritis Ultrasound Scoring System in The Turkish Population PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Knee osteoarthritis is a chronic disease common in middle-aged and older adults, characterized by functional impairment and reduced quality of life due to pain. While physical examination and radiographic Kellgren-Lawrence grading are frequently used in clinical evaluation, the severity of pain does not always correlate with the degree of structural degeneration. Ultrasonography is gaining prominence in osteoarthritis research due to its advantage of simultaneously evaluating both inflammatory and structural components, such as synovial hypertrophy, effusion, power Doppler signal, and osteophytes. The Outcome Measures in Rheumatology (OMERACT) working group has developed a standardized, multidimensional ultrasound scoring system for knee osteoarthritis, … |
KADIR SONGUR; | 2026-03-27 |
| 84 | Prognostic Factors and Predictors of Disease Flare in Patients With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to help find better ways to predict when a flare of your disease (rheumatoid arthritis) might happen. By looking at your registered data, symptoms, disease characteristics, and specific markers in your blood, the investigators hope to help doctors make better decisions about your treatment in the future. The main question it aims to answer is: Can specific patient data, disease characteristics, drug history, … |
ESRAA MOHAMED MAHMOUD; | 2026-02-04 |
| 85 | Evaluation of The Clinical Effectiveness of Pericapsular Nerve Group (PENG) Block and Pulsed Radiofrequency Applications in Chronic Hip Pain PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim of this study is to prospectively compare the effects of the pericapsular nerve group (PENG) block alone and the combination of PENG block with pulsed radiofrequency (PRF) on pain intensity in patients with chronic hip pain. As a secondary aim, the effects of both treatment modalities on hip function are intended to be evaluated using valid and reliable functional assessment scales. Through this study, it is aimed to demonstrate the clinical contribution of adding PRF to the PENG block and to identify a more effective and longer-lasting approach for the interventional treatment of chronic hip pain. |
ÜLKÜ SABUNCU; | 2026-03-18 |
| 86 | Phase 1b, Open-Label, Exploratory Biomarker Basket Study of S-4321 in Participants With An Autoimmune or Immune-Mediated Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multi-center, open-label Ph 1b basket study to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, biomarker response, and preliminary efficacy of S-4321 in adults with autoimmune or immune-mediated disease including rheumatoid arthritis (RA), psoriatic arthritis (PsA), psoriasis (PsO), cutaneous lupus erythematosus (CLE) with or without systemic manifestations, or atopic dermatitis (AD). |
JENNIFER MARTIN; | 2026-03-06 |
| 87 | Impact of Pre-operative Sarcopenia on Functional Recovery After Hip Arthroplasty in Older Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This single-centre, exploratory study at Montpellier University Hospital will investigate whether having low muscle mass and strength before hip-replacement surgery, a condition called sarcopenia, impact the return to everyday independence in people aged 75 years or older. About 20 volunteers, scheduled for surgery because of a recent femoral-neck fracture or severe arthritis that no longer responds to usual care, will give consent, answer brief health questionnaires, attempt simple walking and chair-rise tests if possible, and provide a small blood sample. While they are already under anaesthesia for their planned operation, … |
JEAN BAPTISTE ROBIAUD; | 2026-02-24 |
| 88 | How Can We Prevent The Underdiagnosis of Diabetes and The Undertreatment of Known Diabetes in Patients With Inflammatory Arthritis Treated With Sulfasalazine? PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to examine whether the blood test Hemoglobin A1c (HbA1c) gives an accurate picture of blood glucose levels in patients with inflammatory arthritis who are treated with sulfasalazine. HbA1c is widely used to diagnose and monitor diabetes, but sulfasalazine can shorten red blood cell lifespan and thereby lower HbA1c values independently of actual glucose levels. This may lead to underdiagnosis of diabetes in patients who develop diabetes during sulfasalazine treatment, … |
KLAVS WÜRGLER HANSEN; | 2026-02-18 |
| 89 | Effects and Safety of Single Versus Triple Hyaluronic Acid Injections in The Treatment of Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to directly compare two hyaluronic acid injection protocols in adults with knee osteoarthritis: a single intra-articular injection of Innoryos 2.5% (Single-Shot) and a three-week injection series of Innoryos 2.2% (Triple-Shot). The study aims to determine whether the single injection provides comparable safety, pain relief, … |
UNIVERSITY OF ERLANGEN NÜRNBERG MEDICAL SCHOOL | 2026-01-20 |
| 90 | Phase 1/2a Study to Evaluate The Safety and Tolerability Intra-articular CX-011 to Treat Moderate to Severe Pain From Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Study is designed to evaluate the safety and effectiveness of a drug called CX-011 to treat pain in patients with osteoarthritis of the knee. Osteoarthritis produces pain in the knee (and other joints) that typically is worsened by activities such as long distance walking and is alleviated by rest. |
CARTHRONIX | 2025-12-30 |
| 91 | Effect of Combined Quadriceps and Calf Strengthening Program on Gait, Functionality, and Sleep Quality in Knee Osteoarthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to determine the effects of a combined quadriceps and calf strengthening program on gait, strength, pain, disability, functional mobility, and sleep quality in patients with knee osteoarthritis. A randomized controlled trial will be conducted at Hayatabad Medical Complex, Peshawar. A total of 52 participants aged 40-60 years with grade 2-3 knee osteoarthritis will be recruited using non-probability convenience sampling and randomly allocated into experimental and control groups. Outcome measures include Kinovea software for gait analysis, hand-held dynamometer for strength, Numeric Rating Scale for pain, WOMAC for disability, Timed Up and Go test for function, … |
AISHA RAZZAQ; | 2026-02-11 |
| 92 | A Prospective Evaluation of The Clinical Effectiveness of Perineural Dextrose and Conventional Local Anesthetic Injections in Patients With Symptomatic Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis. Adult patients receiving routine perineural injection therapy will be followed for six months. Pain intensity and functional outcomes will be assessed at baseline and at 1, 3, and 6 months after treatment using validated clinical assessment tools. |
NADIDE KOCA; | 2026-02-03 |
| 93 | Pilot Trial of Intra-articular Stromal Vascular Fraction for The Treatment of Knee Post-Trauma Osteoarthritis and Biomarker Identification Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, non-randomized, interventional, dual site, before-after clinical trial to determine feasibility and safety of a single injection of autologous Adipose Derived (AD) Stromal Vascular Fraction (SVF) for the treatment of knee Post Traumatic Osteoarthritis (PTOA). |
CLAUDE T MOORMAN; | 2026-02-27 |
| 94 | The Effectiveness of Oral Cannabis Extracts for Osteoarthritic Pain: An Internal Pilot, Placebo Controlled, Blinded Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians. Current OA treatments often have limited effectiveness and may cause side effects. As a result, many individuals with OA turn to medical cannabis for pain relief, … |
HANCE CLARKE; | 2026-04-02 |
| 95 | A Between-Group Comparison of First Dorsal Interosseous and Abductor Pollicis Longus Muscle Activation During First Dorsal Interosseous Exercise in Individuals With and Without Thumb Base Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate whether there are differences in muscle activation of the First Dorsal Interosseous (FDI) and the Abductor Pollicis Longus (APL) between individuals with and without trapeziometacarpal osteoarthritis (TMC OA) of the thumb. The study also seeks to identify which exercises are most effective for activating these muscles, in order to inform rehabilitation strategies for patients. The FDI has been defined as a key stabilizer of the thumb TMC joint. However, … |
CARMEN MENAYA FERNANDEZ; | 2026-02-19 |
| 96 | Response of Methotrexate Alone Versus Methotrexate Combined With Etanercept for Achieving Minimal/Low Disease Activity in Patients of Juvenile Idiopathic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This open labelled randomized controlled trial will be carried out at the University of Child Health and the Children’s Hospital, Lahore consisting of 6 months . In total 60 patients (30 in each group) fulfilling the inclusion criteria will be selected and enrolled in this study. Patients will be divided into two groups; Group A (Injection Etanercept+ Tab methotrexate) and Group B (Injection Etanercept+ Tab methotrexate). Data will be collected at baseline, 1,3 and 6 months. Data will be collected and recorded |
FAISAL HANEEF; | 2026-02-04 |
| 97 | Evaluation of The Effectiveness of The Enghien-les-Bains Thermal Spa Treatment in The Rheumatology Indication in Patients With Knee Osteoarthritis. Indirect Comparison Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this interventional study is to evaluate the effectiveness at 6 months of the Enghien-les-Bains thermal spa treatment on functional disability and pain, assessed by the Minimal Clinically Important Improvement (MCII), … |
MAGALI BALLARD; | 2026-01-30 |
| 98 | Effects of 9 Points Electrical Dry Needling on Pain, Range of Motion, Function and Quality of Life in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study will be conducted to compare effects of 9 points electrical dry needling along with standard physical therapy and standard physical therapy alone in knee osteoarthritis patients. |
SHAKIL UR REHMAN; | 2026-02-11 |
| 99 | A Single Ascending Dose Study to Assess The Safety and Pharmacokinetics of Intra-articular AVD275 Injection in Patients With Osteoarthritis of The Knee PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to understand the safety, drug concentration and distribution of an intra-articular injectable formulation of celecoxib, AVD275, in patients with knee osteoarthritis. One single injection at three different doses of the drug will be studied in a sequential order, and each participant will be monitored for 24 weeks over ten clinical visits. |
AVIDENCE THERAPEUTICS | 2026-03-31 |
| 100 | Activating SilverSneakers Benefits for Seniors With Osteoarthritis: Proactive Versus Usual Care PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this pragmatic randomized controlled trial is to test the effects of a brief proactive care intervention involving mailed material and two phone calls on: (1) increasing participation in SilverSneakers exercise programs among older adults with osteoarthritis; (2) improving physical, social and psychological outcomes identified as important to older adults with osteoarthritis; and (3) reducing costly osteoarthritis-related health service use. Approximately 1,454 older adults with osteoarthritis who have SilverSneakers access through their Medicare Advantage plan, but no prior SilverSneakers use, … |
LIZA ROVNIAK; | 2026-02-10 |
| 101 | Italian Version of KOOS-ACL (Knee Injury and Osteoarthritis Outcomes Score – Anterior Cruciate Ligament): Translation, Cross-cultural Adaptation and Validation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Submission of the KOOS ACL questionnaires in Italian for the purpose of validation and cultural adaptation of the KOOS-ACL scale for the Italian population. |
I R C C S OSPEDALE GALEAZZI SANT’AMBROGIO | 2026-02-04 |
| 102 | A Randomized, Double-blind, Placebo-controlled Phase IIa Study to Evaluate The Efficacy and Safety of SHR-3045 Injection in Patients With Moderate to Severe Active Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is ongoing to explore the efficacy and safety of different strengths of SHR-3045 injection in moderate to severe active rheumatoid arthritis. |
ZHANGUO LI; | 2026-03-05 |
| 103 | Effect of Mediterranean and Paleolithic Dietary Interventions on Nutritional Status, Disease Activity, Sarcopenia, and Quality of Life in Adults With Rheumatoid Arthritis: A 12-Week Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effects of Mediterranean and Paleolithic dietary interventions on nutritional status, disease activity, fatigue, sleep, and quality of life in adults with rheumatoid arthritis (RA). Participants aged 40-60 years will be randomly assigned to follow either a Mediterranean diet, a Paleolithic diet, or continue their usual diet for 12 weeks. The study will assess anthropometric measurements, disease activity score (DAS28), laboratory biomarkers (CBC, CRP, ESR, lipid profile, fasting glucose, HbA1c), and patient-reported outcomes. The trial will determine whether these diets improve RA management and overall well-being. |
GEHAD MAGHRABY; | 2026-02-27 |
| 104 | Improving Hypertension Control for Patients With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Rheumatoid arthritis (RA) is a autoimmune disease associated with an increased risk of developing coronary artery disease (CAD) and premature death,. Traditional CAD risk factors like hypertension (HTN) are both very common and poorly controlled among RA patients. Patients with RA face significant challenges in controlling HTN. The goal of this project is to identify barriers to HTN care in patients with RA to reduce CAD events. |
ISAAC SMITH; | 2026-02-06 |
| 105 | A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate The Efficacy and Safety of JNJ-88545223 For The Treatment of Participants With Active Psoriatic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health. |
JANSSEN RESEARCH & DEVELOPMENT | 2026-03-13 |
| 106 | Randomized Double-Blind Study to Evaluate The Efficacy of Transcutaneous Pulsed Radiofrequency (PRF) Treatment for Knee Pain PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objectives * Primary Objective: To evaluate the efficacy of transcutaneous PRF treatment in reducing knee pain compared to a sham intervention * Secondary Objectives: To assess the improvement in functional outcomes and patient satisfaction following PRF treatment. Study Design * Type: Randomized, double-blind, sham-controlled study. * Duration: 6 months * Study Population: Adults aged 40-75 years with chronic knee pain (lasting ≥ 6 months) due to osteoarthritis (OA). * How many patients in each group: 25 patients in each group (according to Janssens et al, … |
MARTINA REKATSINA; | 2026-01-20 |
| 107 | The Effect of Healthy Lifestyle Management Education and Personalized Physical Activity Counseling on Pain, Functionality, Exercise Adherence, and Irisin Level in Patients With Knee Osteoarthritis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Knee osteoarthritis is a common condition that causes knee pain, stiffness, and difficulty in daily activities. Physical activity and exercise are recommended as part of the treatment; however, many individuals have difficulty maintaining regular exercise over time. The purpose of this study is to evaluate the effects of different physical activity intervention approaches on pain, physical function, … |
MUHAMMED ARCA; | 2026-01-12 |
| 108 | An Open-label Study to Evaluate The Safety and Efficacy of GC012F in Patients With Difficult-to-Treat (D2T) Rheumatoid Arthritis Related Papers Related Patents Related Grants Related Experts Highlight: This is An Open-label Study to Evaluate the Safety and Efficacy of GC012F in Patients with Difficult-to-Treat (D2T) Rheumatoid Arthritis. |
YING WANG; | 2026-01-02 |
| 109 | The Role of Iliotibial Band Stiffness Assessed By Shear-Wave Elastography in Objective and Perceived Leg Length Discrepancy After Total Hip Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Patients undergoing total hip arthroplasty (THA) may experience objective or perceived leg length discrepancy (LLD/PLLD), which can negatively affect gait, pelvic balance, and patient satisfaction. The iliotibial band (ITB) plays a critical role in lateral thigh tension transmission, … |
ANKARA ETLIK CITY HOSPITAL | 2026-02-24 |
| 110 | Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty, A Randomized Double-Blinded Controlled Trial Related Papers Related Patents Related Grants Related Experts Highlight: Analgesic Efficacy of Pre-Operative Dose of palmitoylethanolamide in Patients Undergoing total Knee Arthroplasty, A Randomized Double-Blinded Controlled Trial. |
ABDELRAHMAN GABER SAYED ELKHATEEB; | 2026-01-09 |
| 111 | Effectiveness of Short-Course Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized, double-blind, placebo-controlled clinical trial aims to evaluate whether single-dose amoxicillin prophylaxis administered prior to simple tooth extraction reduces postoperative infection rates in immunosuppressed patients with autoimmune rheumatic diseases (ARDs). Although antibiotic prophylaxis is not recommended for healthy individuals undergoing simple extractions, immunosuppressed ARD patients frequently receive antibiotics despite limited evidence supporting this practice. Secondary objectives include assessing infection severity, postoperative complications, and the impact of ARD diagnosis and immunosuppressive treatment on infection risk. |
ELOISA BONFÁ; | 2025-12-10 |
| 112 | Trial of Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is an open-label, randomized, multicenter trial that incorporates a multi-arm design comparing each of 3 non-TNFi (Tumor Necrosis Factor inhibitor) medications to a second TNFi (active control) within a sequential multiple assignment randomized trial design with 2 randomization stages corresponding with clinical decision points. The first randomization addresses whether each of the 3 non-TNFi medications is superior to treatment with a second TNFi. The second randomization allows identification of optimal sequential use of biologics (treatment strategies). |
SUSAN KIM; | 2026-03-23 |
| 113 | A Phase 1b, Open-label, Multi-cohort Study of AZD0120, An Autologous CD19/BCMA Targeting Chimeric Antigen Receptor T-cell, in Adults With Autoimmune Diseases PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), or difficult-to-treat rheumatoid arthritis (D2T RA). |
ASTRAZENECA | 2026-02-11 |
| 114 | Clinical Study of Recombinant Anti-CD19m-CD3 Antibody Injection (A-319) in The Treatment of Active Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of the study was to evaluate the safety and tolerability of A-319 in patients with active rheumatoid arthritis. |
QIUBAI LI; | 2026-01-16 |
| 115 | Effect of Etodolac-Loaded Solid Lipid Nanoparticle Gel As An Adjunct to Physiotherapy in Knee Osteoarthritis: A Randomized Clinical Tria PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Brief Summary: Knee osteoarthritis (OA) is a common, disabling condition affecting the weight-bearing knee joint, leading to pain, reduced function, and muscle weakness, particularly of the quadriceps. Strengthening exercises are recommended to improve joint stability, physical function, and slow disease progression. Etodolac, a selective NSAID approved for osteoarthritis, … |
OLA MOHAMED ELSAYED ELGOHARY; | 2025-12-29 |
| 116 | Individual Differences in Gait and Osteoarthritis Pain PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are: Why do some people with knee osteoarthritis have more severe disabling pain than others, even though the degenerative changes in their knees are similar? What are the factors that contribute to walking pain in people with knee osteoarthritis? Participants will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing. |
BENEDICT ALTER; | 2026-01-29 |
| 117 | Multimodal Treatment of Knee Osteoarthritis: Comparison of The Combination of Therapeutic Exercise and Noninvasive Neuromodulation (NESA) Versus Therapeutic Exercise and Transcutaneous Electrical Nerve Stimulation (TENS) on Pain, Function, and Mental Health in People Over 60 Years of Age PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To analyze the effects of therapeutic exercise combined with noninvasive neuromodulation (NESA) or transcutaneous electrical nerve stimulation (TENS) on improving clinical symptoms such as joint pain and stiffness, as well as its impact on the functionality, mental health, and quality of life of people over 60 years of age with knee osteoarthritis. |
AGUSTÍN AIBAR ALMAZÁN; | 2026-03-06 |
| 118 | Randomized Controlled Study of The Effects of Core Stabilization Exercises in Addition to Knee Exercises in Female Patients With Gonarthrosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Osteoarthritis (OA) is a non-inflammatory degenerative disease characterized by progressive deterioration of cartilage tissue, synovial membrane, and joint capsule, primarily affecting weight-bearing joints. Individuals with knee osteoarthritis exhibit weakness in the trunk and periarticular muscles. This loss of strength in the trunk and periarticular muscles increases the load on the joint, contributing to the development and progression of the disease. This study aimed to investigate the effects of core stabilization, applied in addition to knee muscle exercise programs, on clinical symptoms and functional capacity in individuals with knee osteoarthritis. |
SELVIN BALKİ; | 2026-03-19 |
| 119 | Effect of Gastrocnemius Myofascial Release on Pain and Physical Function Outcomes in Females With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine whether gastrocnemius myofascial release is effective in reducing pain and improving physical function in females with knee osteoarthritis. The main question this study aims to answer are: * Does adding gastrocnemius MFR to conventional physical therapy treatment influence pain, physical function, foot posture, and knee disability compared to conventional physical therapy treatment and sham MFR in knee osteoarthritis? * Participants receive gastrocnemius myofascial release treatment or sham gastrocnemius myofascial release treatment for 3 times weekly for 4 weeks for both groups. |
HEND MAHMOUD HAMMAM FATHI SOLIMAN; | 2026-04-02 |
| 120 | Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life. |
VASILEIOS BALOMENOS; | 2026-02-20 |
| 121 | The Dynamic Dual-Mode Alignment Optimization and Intelligent Precision Knee Preservation System for Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to verify whether the dynamic dual-mode alignment optimization + intelligent precision knee-preserving system (integrating static/kinematic target alignment, CT-based preoperative three-dimensional \[3D\] planning, 3D-printed guide plates, and intraoperative augmented reality \[AR\] real-time feedback) achieves a greater relative reduction in peak knee adduction moment (KAM) at 12 months postoperatively, while maintaining or improving knee clinical function and without increasing perioperative or long-term complication rates, compared with traditional knee-preserving strategies. The target population is patients aged 40-70 years with knee osteoarthritis (KOA; … |
FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY | 2025-12-16 |
| 122 | Prospective Evaluation of Baricitinib’s Effects on Procoagulant State and Atherogenic Index in Rheumatoid Arthritis Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective interventional study aims to evaluate the effects of baricitinib on disease activity, lipid profile, atherogenic index, and procoagulant biomarkers including monocyte-derived human tissue factor and D-dimer in patients with rheumatoid arthritis, compared with conventional therapy. |
NOURHAN ELSAEED ABDELMABOD ELHAISH; | 2026-01-22 |
| 123 | Unicompartimental Vs Total Knee Arthroplasty for Medial Knee Osteoarthritis: A Prospective, Ramdomized, Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether partial knee replacement (unicompartmental knee arthroplasty, UKA) or total knee replacement (total knee arthroplasty, TKA) leads to better clinical and functional outcomes in adults with medial knee osteoarthritis who are candidates for knee arthroplasty. The main questions the study aims to answer are: * Does UKA or TKA result in better patient-reported outcomes, such as knee pain, function, and quality of life (measured by Oxford Knee Score, WOMAC, … |
MEDICAL UNIVERSITY OF GRAZ | 2025-12-02 |
| 124 | Borrelia Arthritis – A Hidden Cause of Arthritis in Danish Patients? Sub-study 1:Incidence&Outcomes Sub-study 2:Characterisation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Why is this study being done? Borrelia arthritis is a joint infection caused by Borrelia bacteria transmitted by tick bites. It often affects the knee and can cause prolonged pain and swelling if not diagnosed and treated in time. While well recognized in North America, Borrelia arthritis is considered rare in Europe. Recent findings from the investigators in Denmark suggest it may be more common than previously thought and frequently diagnosed late. The aim of this study is to improve knowledge about how often Borrelia arthritis occurs in Denmark, how it presents, how long diagnosis takes, … |
FREDRIKKE CHRISTIE KNUDTZEN; | 2026-01-20 |
| 125 | Ultrasound Neuroimmune Modulation in Adults With Rheumatoid Arthritis: Feasibility and Safety in A Multicenter, Randomized, Double-Blind, Sham-Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This two-stage, multicenter clinical trial is designed to evaluate the feasibility, safety, and preliminary efficacy of at-home ultrasound stimulation to activate immune-neuromodulation in patients with rheumatoid arthritis (RA) and at least moderate disease activity. The study will enroll up to 40 participants at up to 6 sites across 2 stages. The findings from this trial will directly inform the design and power calculations for a future pivotal trial by identifying an appropriate effect size and confirming protocol feasibility and safety for a daily home-use therapy. |
DHIMAN BASU; | 2026-01-23 |
| 126 | An Exploratory Clinical Study on The Protective Effect of Cycling on The Ankle Joint in Gout PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study divided the enrolled gout patients into a jogging group and a cycling group to investigate 1）the effectiveness of cycling intervention in reducing the recurrence risk of gouty ankle arthritis compared with jogging. 2) To clarify the influence of different exercise patterns on the ultrasonic manifestations of gouty ankle arthritis; 3) Clarify the impact of different exercise methods on the blood uric acid levels of gout patients; |
ZHU XIAOXIA; | 2025-12-31 |
| 127 | Value of Adding T2mapping Sequence to Routine MRI Protocol in Assessment of Knee Articular Cartilage in Early Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis |
SHROUK MOHAMED GAD; | 2026-01-05 |
| 128 | The Effect of Preoperative Whey Protein and Physical Exercise Support on Recovery After Total Hip Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: The aim of this project is to evaluate the effects of preoperative whey protein supplementation and a physical exercise program on postoperative recovery outcomes in patients undergoing total hip arthroplasty (THA). Specifically, inflammatory markers (CRP), nutritional status (albumin), mobilization time, length of hospital stay, and physical and social functioning will be assessed. As one of the first randomized controlled trials in Turkey to focus on the preoperative period and to evaluate a combined nutrition and exercise intervention in elderly surgical patients, … |
HÜMEYRA YÜKSEL; | 2026-01-09 |
| 129 | A Dose-finding Phase I Study of F8IL10 Intra-articular Treatment in Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the safety of F8IL10 when administered by intra-articular injection and to determine the maximum tolerated dose (MTD) in order to establish the recommended dose (RD) in patients with Reumatoid Arthritis. |
FILIPPO CRESCENTINI; | 2026-01-09 |
| 130 | Partial Wrist Denervation in Comminuted Articular Distal Radius Fractures PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: the aim of Partial Wrist Denervation in Comminuted articular Distal Radius Fractures is to decrease incidence of chronic wrist pain follwing this type of fracture |
MOMEN MOUSTAFA; | 2026-02-06 |
| 131 | Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the acute effects on hypoalgesia of training to failure using blood flow restriction (BFR) with dynamic occlusion versus BFR with fixed occlusion in patients with severe gonarthrosis. Two different training conditions will be performed with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure. Each participant will complete two individual sessions under different training conditions, randomly assigned with a 72-hour interval between sessions. |
ADRIÁN ESCRICHE ESCUDER; | 2025-12-31 |
| 132 | Anti-Citrullinated SR-A Peptide (Anti-csp)Antibody As A Biomarker for Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: 1. To measure serum level of anticitrullinated SR-A peptide antibody (anti-CSP) in RA patients compared to healthy controls . 2. To assess the diagnostic performance of anti-CSP for RA specifically seronegative RA patients. 3. To evaluate correlation of serum anti-CSP level with disease activity and functional disability scores in RA patients. |
WALAA SHARIF EID AHMED; | 2025-08-28 |
| 133 | A Randomized, Double-Blind, Multicenter, Phase II/III Clinical Study Comparing Umbilical Cord-Derived Mesenchymal Stem Cell Secretome Versus Sodium Hyaluronate on Clinical Outcomes, Pain, and Function in Patients With Kellgren-Lawrence Grade 2-3 Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a randomized, double-blind, multicenter Phase II/III clinical trial designed to evaluate the effectiveness and safety of umbilical cord-derived mesenchymal stem cell (UC-MSC) secretome compared with sodium hyaluronate in patients with knee osteoarthritis. Knee osteoarthritis is a common degenerative joint disease that causes chronic pain and functional limitation. Participants will be randomly assigned to receive intra-articular injections of either UC-MSC-derived secretome or sodium hyaluronate. The study aims to assess improvements in knee pain, physical function, and overall clinical outcomes, as well as to evaluate the safety of the interventions over the study period. |
UNIVERSITAS SRIWIJAYA | 2026-01-13 |
| 134 | Multiprofen-CC to Reduce Pain in Hand Arthritis (MRP-HAND): A Crossover Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects. Participants will: * Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, … |
CAROLYN LEVIS; | 2026-01-07 |
| 135 | Comparison of The Effects of Pain Neuroscience Education and Vagus Nerve Stimulation on Recovery in Individuals With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In the context of this randomized controlled study, patients who are diagnosed with Rheumatoid arthritis in Cerrahpaşa Faculty of Medicine Hospital, will be taken into a rehabilitation program by a qualified physiotherapist to improve their pain, pain perception, inflammatory markers and quality of life, with one of the pain neuroscience education, vagal nerve stimulation and traditional exercise interventions. The results of each intervention method will be analyzed and compared at the end of the 8 weeks study protocol. |
SIMAY AKDEMIR; | 2025-12-10 |
| 136 | Acute Responses to Different Blood Flow Restriction Exercise Configurations With Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the acute effects of blood flow restriction (BFR) training on hypoalgesia and neuromuscular responses in patients with severe gonarthrosis by comparing the application of pressure with a dynamic versus a fixed configuration. There will be six different training conditions with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure; 3) 50% RM and 50% BFR with dynamic pressure; 4) 50% RM and 50% BFR with fixed pressure; … |
ADRIÁN ESCRICHE ESCUDER; | 2026-01-05 |
| 137 | Safety and Feasibility of The Neurolyser XR Device for The Treatment of Predominantly Medial Chronic Knee Pain Due to Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study involves the use of sound waves to block pain signals caused by osteoarthritis of the knee. The sound waves are tightly focused on a specific area of the nerve. The sound waves cause a break in the nerve which carries pain signals. Sound waves transmit through the skin so there is no need for needles. The procedure takes approximately one hour. The device has been approved in Health Canada and Europe for the treatment of lower back pain. This study is to evaluate the use of the same device for people in Canada who have knee pain related to osteoarthritis. |
FUSMOBILE | 2026-01-07 |
| 138 | A Randomized, Double-Blind, Phase 2, Efficacy and Safety Cross-Over Study of Allogeneic HB-adMSCs Vs Placebo for The Treatment of Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis Related Papers Related Patents Related Grants Related Experts Highlight: Methodology: Randomized, double-blind, AB/BA cross-over study with a washout period of 12 weeks. Treatment Duration: 8 weeks per group General Objectives: To assess the efficacy and safety of multiple intravenous infusions of allogeneic HB-adMSCs by improving signs and symptoms of juvenile idiopathic arthritis in this subject population. Number of Subjects: 66 (6 subjects in Cohort 1 and 60 subjects in Cohort 2) Indication: Juvenile Idiopathic Arthritis |
THANH CHENG; | 2026-01-07 |
| 139 | Effects of Mobilization With Movement Versus Sustained Mobilization Along With Eccentric Exercises on Pain & Functional Disability in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This article focused on people diagnosed with grade III Knee OA with sample size of 68 patients , who will randomly divided into two groups . Group A received Mulligan’s MWM while group B received Kaltenborn’s Sustained Mobilization along with eccentric exercises. The goal of the study was to compare the effectiveness of these two treatment conditions in reducing knee pain and improving joint function decreasing disability in daily activities. The patients followed a structured treatment plan over a set period and outcomes will measured using reliable clinical tools such as NPRS for pain KOOS for functional disability and Goniometer for ROM. |
LAHORE UNIVERSITY OF BIOLOGICAL AND APPLIED SCIENCES | 2026-01-02 |
| 140 | Long-Term Effects of Mobithron Advance on Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if the Mobithron Advance drug works to treat and slow the progression of osteoarthritis (OA) in patients. It will also learn about the safety and long-term effects of this drug. The main questions it aims to answer are: * Does long-term administration of Mobithron Advance can modify the progression of knee osteoarthritis with Kellgren-Lawrence grade 1 to 3 in HUSM patients? * Does long term usage of Mobithron Advance has safety profile? Researchers will compare the Mobithron Advance drug to a placebo (a look-alike substance that contains no drug) to see if said drug works to treat OA. Participants will: * Undergo pre-study assessment (baseline assessments) during first visit * Take oral Mobithron Advance daily for 1 year * Visit the clinic once at 3 months, 6 months and 12 months intervals from the initial visit for follow up assessments |
AMRAN AHMED SHOKRI; | 2026-01-07 |
| 141 | Platelet Rich Plasma for Musculoskeletal Conditions PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain levels, functional abilities, and overall patient satisfaction. This will develop a robust registry of patients treated with PRP for a range of MSK conditions. These conditions include, but are not limited to, osteoarthritis (OA) of the knee, hip, glenohumeral joint, elbow, ankle, and sacroiliac joint, as well as rotator cuff tendinopathy, lateral and medial epicondylitis, plantar fasciitis, patellar tendinopathy, Achilles tendinopathy, and proximal hamstring tendinopathy. |
DANIEL CUSHMAN; | 2026-03-23 |
| 142 | The Efficacy of Ultrasonication in Combination With Corticosteroid Intraarticular Injection for Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates whether ultrasound therapy applied prior to intra-articular corticosteroid injection can enhance the treatment efficacy for patients with joint arthritis and assess its safety. Adult patients diagnosed with arthritis in the limbs who are indicated for corticosteroid injection are eligible, while patients with joint replacement, hip joint involvement, gout, infectious arthritis, or local cellulitis are excluded. Ultrasound therapy is a valuable physical therapy tool for musculoskeletal diseases, producing therapeutic effects through thermal and non-thermal mechanisms. It can improve tissue extensibility, reduce joint stiffness, increase local blood flow, enhance metabolism during tissue repair, … |
KUO-LUNG LAI; | 2026-01-23 |
| 143 | Monocentric, Randomized Study, Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Some patients complain of articular noise (such as clicking, snapping, cracking or popping) after a total knee replacement. Controversy remains about whether there is a correlation between articular noise and worse outcomes following a knee replacement. A study by Nam et al. on 1540 patients revealed an association between noise and residual symptoms 30 days after they received a total knee replacement. Conversely, … |
ELSAN | 2026-03-04 |
| 144 | Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Study to Evaluate The Efficacy and Safety of D-2570 in Subjects With Active Psoriatic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multicenter, randomized, double-blind, placebo-controlled clinical trial. The target population is patients with active psoriatic arthritis. A total of 222 subjects are planned to be included. |
YI LIU; | 2026-01-02 |
| 145 | Regulatory Post-Marketing Surveillance to Assess Safety and Effectiveness in Hidradenitis Suppurativa, Pediatric Plaque Psoriasis and JIA Treated With Cosentyx®(Secukinumab) in Korea : A RPMS Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Regulatory Post-Marketing Surveillance in hidradenitis suppurativa, pediatric plaque psoriasis and JIA treated with Cosentyx®(secukinumab) in Korea |
NOVARTIS PHARMACEUTICALS | 2026-03-05 |
| 146 | Evaluation of The Neuromodulatory Effects of Transcranial Direct Current Stimulation on Pain in Knee Osteoarthritis Patients: A Double Blind Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Knee osteoarthritis (KOA) is a common condition that causes long-lasting knee pain and difficulty with daily activities. Many patients have pain that is stronger than expected from joint changes because the nervous system becomes more sensitive to pain. Transcranial direct current stimulation (tDCS) is a non-invasive technique that uses a small electrical current applied to the scalp to help reduce pain sensitivity. This study will test whether active tDCS over the primary motor cortex can reduce pain and improve function in people with knee osteoarthritis. A total of 102 participants will be randomly assigned to receive either active tDCS or sham (placebo) stimulation. All participants will receive 15 sessions over three weeks. We will measure pain intensity, pain sensitivity, physical function, depression, cognition, and quality of life before the treatment, after the 3-week treatment program, and again at the 1-month follow-up. |
NOURHAN E. ELKARALY; | 2025-12-24 |
| 147 | An Implementation Science Approach to Evaluating Self-Administered Acupressure for Knee Osteoarthritis in Older-Aged Adults in The Community PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the implementation and effectiveness of a self-administered acupressure (SAA) program for knee osteoarthritis (OA) among older adults in Hong Kong community centers. Using a pragmatic cluster randomized controlled trial (RCT) and mixed-methods approach, the research will assess the reach, adoption, implementation, maintenance, and effectiveness of the SAA program in real-world settings, with the goal of informing scalable interventions for knee OA management. |
WING-FAI YEUNG; | 2026-01-09 |
| 148 | Presence of Neuropathic Pain in Knee Osteoarthritis: Relationship Between Pain Severity and Functional Status PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability. Pain in knee OA involves a complex pathophysiological structure including both nociceptive and neuropathic mechanisms. Identifying the neuropathic pain component is clinically significant for improving quality of life and functional recovery. This cross-sectional controlled clinical study aims to determine the prevalence of neuropathic pain in patients with knee OA and evaluate its impact on pain severity and functional status. Patients will be categorized based on the Douleur Neuropathique 4 (DN4) questionnaire and assessed using various pain and functional scales. |
ESER KALAOGLU; | 2026-01-26 |
| 149 | Study on The Impact of Nursing Interventions Based on The ABC-X Model on Psychological Resilience and Family Functioning in Patients After Total Knee Arthroplasty PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The ABC-X model is a systematic intervention approach based on stress source analysis and adaptation theory. It emphasizes the dynamic interaction between stressors (A), coping resources (B), cognitive appraisal (C), and crisis outcomes (X). By systematically assessing patients’ psychosocial stress, integrating family and social support resources, and optimizing disease cognition, it helps patients and their families alleviate psychological pressure and cope with disease challenges. This study aims to explore the impact of nursing interventions based on the ABC-X model on coping styles and family functioning in patients after total knee arthroplasty. |
THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE | 2026-01-13 |
| 150 | Effects of Femoral Nerve Mobilization on Pain Intensity, Function, Quality of Life and Central Sensitization in Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Knee osteoarthritis (KO) is considered as a cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality. There is a limited knowledge about using femoral nerve mobilization in treating patients with arthritic changes. Objectives: This study will be designed to determine the efficacy of adding of femoral nerve mobilization on pain intensity, function, … |
MOHAMMAD MOUSTAFA ALDOSOUKKI HEGAZY; | 2026-01-09 |
| 151 | Comparison Between Haematological Parameters and Musculoskeletal Ultrasound Findings of Rheumatoid Arthritis Patients Recieving JAK Inhibitors Versus Traditional Treatment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects about 1% of the world’s population \[1\]. The disease is characterized by synovial membrane inflammation. The impact of RA on quality of life is significant, as it can lead to considerable disability, reduced mobility, and an increased risk of additional health complications \[2\]. CsDMARDs are the first-line drugs for RA treatment, of which methotrexate (MTX) is the cornerstone drug and monotherapy is recommended as the first choice (3). However, … |
ASMAA GAMAL MOHAMED ABD ELAAL; | 2025-12-09 |
| 152 | Low-Dose Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research is to compare low-dose radiotherapy to corticosteroid injection for treatment of hand/wrist osteoarthritis. |
TERIN T. SYTSMA; | 2026-02-13 |
| 153 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II/III Clinical Study to Evaluate The Efficacy and Safety of Picankibart in Patients With Active Psoriatic Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, double-blind, placebo-controlled Phase II/III clinical trial evaluating the efficacy and safety of picankibart (IBI112) in patients with active psoriatic arthritis (PsA). The study consists of two stages: Phase II dose-finding (n=90) and Phase III confirmatory (n=132). Participants will receive subcutaneous (SC) injections of either picankibart (200mg) or placebo with different dosing schedules, with placebo crossover to active treatment at Week 26. The Phase II portion will identify optimal dosing for Phase III, which will confirm efficacy. The study will evaluate improvements in joint symptoms, physical function, quality of life, … |
XIAOYONG MAN; | 2026-03-20 |
| 154 | Results Between Robotic-Assisted and Manual Total Knee Arthroplasty With Kinematic Alignment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomised controlled trial will include patients with end-stage osteoarthritis of the knee undergoing primary TKR. Patients meeting the criteria that consent to be in the study will be randomised at a ratio of 1:1 to either manual TKR or robotic-assisted TKR. The primary objective will assess pre- and postoperative HKA angle, CPAK and range of motion using goniometer to compare two groups.The secondary objectives are to compare patient expectation, functional ability, quality of life using functional 48-point Oxford Knee Score and Forgotten joint score. |
JAKUB BŁASZCZYK; | 2026-03-05 |
| 155 | Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis: Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Evaluation of intra-articular injections in knee osteoarthritis using frozen-stored PRP. Compared with intra-articular injections of PRP applied at the time of collection. |
MIKS HOSPITAL | 2026-01-09 |
| 156 | A Visualization Clinical Study Using A Handheld MPI Imaging Device for Monitoring Mesenchymal Stromal Cells in Osteoarthritis Treatment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to evaluate the use of a handheld Magnetic Particle Imaging (MPI) device for real-time, non-invasive monitoring of human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in patients with knee osteoarthritis (OA). The primary objective is to visualize and quantify the distribution, retention, and survival of SPIO (superparamagnetic iron oxide)-labeled MSCs within the joint space following intra-articular injection. By correlating MPI signal dynamics with established clinical outcomes (e.g., WOMAC, VAS scores) and anatomical MRI assessments, … |
TUO SHAO; | 2025-12-31 |
| 157 | PLATE: Health Effects of Plant-Based Diet in Patients With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the effect of a plant-based diet (PBD) intervention in adults with Rheumatoid Arthritis (RA) on disease activity. The investigators hypothesize that if patients with RA follow a 100% PBD over a 16-week period it will lead to improvements in: \- Disease activity (measured by DAS28), including reduction in symptoms and overall improvements in health-related quality of life. The effects of the PBD will be compared to a habitual diet, … |
ALLAN LINNEBERG; | 2026-03-18 |
| 158 | A Multicentre, Parallel-group, Phase II, Randomised, Double-blind, 4 Arm Study to Evaluate Efficacy and Safety of AZD1163 in Participants With Moderately-to-Severely Active Rheumatoid Arthritis (LaunchPAD-RA) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Phase II study in participants with moderately-to-severely active rheumatoid Arthritis (RA) to evaluate efficacy and safety of AZD1163. |
ASTRAZENECA | 2026-03-24 |
| 159 | Positional Release Technique of Iliotibial Band and Pes Anserine Versus Proprioception Exercise on Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: this studty was conducted to compare the effect of the positional release technique of the iliotibial band and Pes Anserine Versus Proprioception Exercise on Patients with knee osteoarthritis. |
NABIL MAHMOUD ISMAIL ABDEL-AAL; | 2025-12-16 |
| 160 | Validity And Reliability Of The Four Square Step Test In Individuals With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This cross-sectional observational study aims to evaluate the validity and reliability of the Four Square Step Test (FSST) in individuals with rheumatoid arthritis. In addition, the study will investigate the associations between FSST performance and clinical parameters including disease activity, quality of life, pain, and muscle strength. All assessments will be conducted according to a pre-defined standardized protocol. The order of measurement tools will be randomized to minimize potential bias, … |
ZEYNAL YASACI; | 2025-12-18 |
| 161 | Combined Use of PRP and Hyaluronic Acid for Infiltrative Treatment of Patients With Knee Osteoarthritis – Randomized Controlled Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: PRP+HA-23 is a double-blind randomized controlled clinical trial with 1:1:1 allocation. The objective of the study is to evaluate by a randomized controlled, double-blind clinical trial the efficacy and safety of viscosupplementation-associated PRP infiltration compared with PRP-only or HA-only infiltration for the treatment of patients with knee osteoarthritis. |
DAVIDE REALE; | 2026-02-03 |
| 162 | An Open-label, Randomized, Parallel-group, Noninferiority Study to Evaluate The Pharmacokinetics of Bimekizumab Administered Intravenously or As A Subcutaneous Injection in Participants With Active Psoriatic Arthritis And/or Active Axial Spondyloarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To demonstrate that bimekizumab administered intravenously is noninferior to subcutaneous administration. |
UCB BIOPHARMA SRL | 2026-03-27 |
| 163 | A Remotely – Applied Behaviorally- Designed Intervention Incorporating Gamification, Social Incentives, and Health Coaching to Improve Durability of Physical Therapy for Knee Osteoarthritis (ReAKTIV) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aims are to determine whether 1) an incentive based on behaviorally-enhanced gamification and social incentives and 2) health coaching can promote adherence to exercise and physical activity after physical therapy for osteoarthritis of the knee (KOA). The research design is a randomized clinical trial with factorial design This randomized clinical trial of 254 patients using a factorial design will leverage a clinical trial platform developed through the University of Pennsylvania that allows for the remotely capture important patient-reported outcomes and other interaction through a participant’s smart phone. The investigators will randomize participants to receive social incentives with gamification to promote adherence to prescribed exercises as well as maintenance of greater levels of physical activity and compare to controls that receive a Fitbit but no additional incentive. Participants may also be randomized to receive a health coach. The investigators will utilize mobile applications for smart phones and wearable activity trackers through the Way-to-Health platform and assess, in real time, the impact of the interventions on patient-reported function and pain (as measured by the Knee Osteoarthritis Outcome Score) as well as physical activity. Participants will be followed for 2 years, with a total of 5 in-person visits. Knee osteoarthritis (KOA) is one of the most prevalent and disabling conditions among Veterans and accounts for high morbidity and high costs for the VA. Importantly, while physical therapy is valuable for patients with KOA, lack of adherence to home exercises and low overall physical activity limit the durability of response. The current proposal aims to address two important knowledge gaps in the management of KOA in order to improve pain and function. |
JOSHUA F. BAKER; | 2026-01-08 |
| 164 | Investigating The Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in Growth Factors (PRGF) in patients with knee osteoarthritis (KOA). The study aims to assess whether this cell-free, biologically enriched therapeutic combination can reduce pain, improve joint function, and promote cartilage repair. |
NOREEN LATIEF; | 2025-09-05 |
| 165 | Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Lower extremity varicose veins (LEVV) are common among elderly patients and can cause leg heaviness, pain, and swelling. In some older adults, venous congestion may contribute to knee or peri-knee pain, … |
CHUNSHUI HE; | 2025-11-20 |
| 166 | Comparing High Intensity Stretch Device Combined With Physical Therapy Versus Physical Therapy Alone to Prevent Motion-Restoring Surgery Following Primary Total Knee Arthroplasty: Study Protocol for A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether adding a stretching device to standard physical therapy can help people regain knee bending after total knee replacement surgery. Some people have difficulty bending their knee during recovery. When this happens, doctors may recommend another procedure called motion-restoring surgery to improve knee movement. This study aims to answer two main questions. First, does adding a hydraulic high-intensity stretching device to physical therapy help people regain knee bending after surgery? Second, does using the device affect recovery, daily activities, … |
ERMI | 2026-03-06 |
| 167 | Comparison of The Effects of Basic Body Awareness Therapy to Conventional Physiotherapy and Home Exercise Program in Individuals With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Osteoarthritis (OA) is a chronic, degenerative joint disease associated with aging and is recognized by the World Health Organization as a primary health condition. It is one of the leading causes of chronic disability worldwide. Structural changes occurring at the bone and joint margins in OA lead to a variety of symptoms and clinical findings associated with the deterioration of articular cartilage integrity. Clinical guidelines recommend a combination of exercise therapy tailored to individual needs, weight loss, and patient education prior to considering arthroplasty. However, achieving satisfactory long-term outcomes remains challenging, … |
EMINE ESRA DİKMEN; | 2026-02-09 |
| 168 | A Phase II, Multicenter, Double-Blind, Placebo-Controlled Study to Assess The Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have An Inadequate Response or Intolerance to TNF And/or JAK Inhibitors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe rheumatoid arthritis (RA) who have an inadequate response or intolerance to TNF and/or JAK inhibitors. |
HOFFMANN LA ROCHE | 2026-04-03 |
| 169 | Efficacy of IPACK Block Combined With Intra-articular Steroid Injection in Advanced Knee Osteoarthritis: A Retrospective Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Osteoarthritis (OA) is a degenerative joint disease characterized by the progressive degeneration of articular cartilage resulting from the interaction of genetic, metabolic, and biochemical factors and is often accompanied by secondary inflammation. This condition represents a pathological process involving the dynamic interaction of cartilage degradation and repair mechanisms affecting the cartilage, subchondral bone, and synovium. Osteoarthritis is the most common joint disease worldwide and represents one of the leading causes of physical disability. Pain is the most prominent symptom of osteoarthritis. It typically increases with activity and decreases with rest. As the disease progresses, … |
HALIL IBRAHIM ALTUN; | 2026-03-11 |
| 170 | Effectiveness of A Herbal Supplement Containing Boswellia Serrata, Curcuma Longa, and Vitis Vinifera in Patients With Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effectiveness and safety of a combined herbal supplement containing Boswellia serrata, Curcuma longa, and Vitis vinifera in adults with clinically diagnosed knee or hip osteoarthritis. The primary objective is to determine whether the supplement improves osteoarthritis-related symptoms. The supplement will be compared with a placebo. Participants will: * take the supplement and placebo for 4 weeks each, one at a time; * complete validated questionnaires (6 times online) * perform three performance-based physical tests (6 times online) * provide a urine sample |
PATRYCJA BRODKA PEDRO; | 2026-01-29 |
| 171 | Medium-and Long-term Efficacy of Two Ultrasound-guided Intra-articular Injections of OnabotulinumtoxinA (Botox®) Combined With Custom-made Rigid Splinting in Painful Base-of-thumb Osteoarthritis : A Randomized Double-blind Controlled Trial in Three-parallel Arms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this study will be to compare the effects of 2 intra-articular injections of onabotulinumtoxinA with those of 1 intra-articular injection of onabotulinumtoxinA and 1 of normal saline and those of 2 intra-articular injections of normal saline on base-of-thumb pain at 6 months after the first injection. |
CHRISTELLE NGUYEN; | 2026-04-03 |
| 172 | A Phase 1, Multicenter, Randomized, Placebo-Controlled, Investigator- and Participant-Blinded, Single- and Multiple-Ascending Dose Study to Evaluate Safety, Tolerability, and Pharmacokinetics of LY4213663 in Healthy Participants, and Two Open-Label, Multiple-Dose Evaluations of LY4213663 in Patients With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate how well LY4213663 is tolerated and what side effects may occur in healthy participants and participants with rheumatoid arthritis (RA). The study drug will be administered either subcutaneously (SC) (under the skin) or intravenously (IV) (into a vein in the arm). Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study will last approximately 33 weeks excluding screening. |
VISHALA CHINDALORE; | 2026-01-20 |
| 173 | An Open-label, Phase I Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Surovatamig Following Single-ascending Dose and Step-up Dose Administration to Adult Participants With Rheumatoid Arthritis or Systemic Lupus Erythematosus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This open-label, Phase I study will assess the safety and tolerability of surovatamig and characterise its PK and PD following subcutaneous administration to participants with RA or SLE. |
ASTRAZENECA | 2026-02-17 |
| 174 | Clinical Study of Myofascial Trigger Points(MTrPs) Injection in The Treatment of Chronic Musculoskeletal Pain(CMP), Chronic Migraine and Cervicogenic Headache PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients’ quality of life. Hip osteoarthritis is a common type of CMP. Currently, both domestic and international studies have confirmed that glucocorticoid injection at myofascial trigger points(MTrPs) can alleviate patients’ pain symptoms. MTrPs injection is safe and easy to operate, and can improve the clinical management efficiency of patients with knee osteoarthritis. Therefore, we designed a prospective, randomized controlled, blinded outcome, … |
FANG LUO; | 2026-01-16 |
| 175 | Long-term Treatment Strategies and Effectiveness of Secukinumab in Juvenile Idiopathic Arthritis Patients of Psoriatic and Enthesitis-related Arthritis Categories: Secondary Use of Data and Primary Data Collection From The German BIKER Registry PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to understand the long-term treatment strategies in children and adolescents diagnosed with ERA or JPsA who received secukinumab and achieved inactive disease and to evaluate the long-term treatment effectiveness of secukinumab in the ERA or JPsA patients in the postauthorization setting. |
NOVARTIS PHARMACEUTICALS | 2025-09-24 |
| 176 | Multicenter, Randomized, Double-blind, Active Control, Parallel, Non-inferior, Phase 4 Clinical Trial to Assess Efficacy and Safety of Laybon Tab. in Patients With Knee Osteoarthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This Phase 4, multicenter, randomized, double-blind, active-controlled, parallel study aims to evaluate the non-inferiority of Laybon Tab. compared to Layla Tab. (PMG Pharm Co., Ltd.) in patients with knee osteoarthritis. Participants will receive either Laybon Tab. or Layla Tab. for 8 weeks. The primary outcome is the change in knee pain during activity, assessed by a 100 mm pain VAS over the previous 24 hours. |
MATHER’S PHARM | 2025-10-02 |
| 177 | Comparison of Suzetrigine and Oxycodone for Postoperative Pain and Analgesic Requirements After Primary Total Knee Arthroplasty: A Prospective, Randomized Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a control group of TKA patients receiving postoperative Oxycodone. |
ARTHUR MALKANI; | 2025-10-28 |
| 178 | A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating The Safety and Efficacy of PPV-06 Active Immunotherapy in Patients With Inflammatory Knee Osteoarthritis (KOA) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: PPV-06 targets interleukin-6, a key molecule implicated in many inflammatory diseases such osteoarthritis. PPV-06 is used to induce the production of antibodies directed against IL-6. The antibodies produced will neutralize the interleukine-6 involved in the body’s inflammatory process. The goal of this clinical trial is to test the safety and efficacy of PPV-06 in participants with Knee Osteoarthritis. The main questions are to evaluate if PPV-06 can reduce pain and improve functioning in participants with knee osteoarthritis, … |
PEPTINOV SAS | 2025-08-12 |
| 179 | Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This multicenter, randomized, controlled, single-blind prospective study aims to establish an evidence-based protocol for discontinuing long-term low-dose glucocorticoids in patients with rheumatoid arthritis (RA). The study will compare two tapering strategies (1) a split-dose tapering method, in which the 5 mg tablet is divided into halves and gradually reduced, and (2) a sequential 1 mg-by-1 mg tapering method. A total of 206 patients (including 50 from Seoul National University Hospital) will be enrolled and followed for six months. Participants will be randomly assigned to one of the two tapering arms, … |
EUN BONG LEE; | 2025-11-25 |
| 180 | Transforming Health Habits: Evaluating An Online Wellness Program for Individuals With Rheumatological Conditions PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this project is to critically evaluate the effectiveness of an online health program designed to improve diet and self-care in patients with rheumatological conditions, including rheumatoid arthritis (RA), Sjogren’s syndrome (SS), systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), psoriatic arthritis (PsA), Additionally, investigators will assess the program’s effectiveness, as well as the challenges and facilitators involved in using an online wellness program to reduce fatigue and enhance the quality of life in patients suffering from these conditions. |
TERRY L. WAHLS; | 2026-01-08 |
| 181 | Effect Of Sensory Motor Training Versus Resistance Training On Improving Pain, Balance And Functional Activities Among Individuals With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to address this gap by comparing the effects of sensory-motor training versus resistance training on pain, balance and functional activities, specifically in patients with early-stage knee osteoarthritis. In Pakistan, Knee Osteoarthritis is a common condition that significantly impacts many individuals’ quality of life. While research exists on various exercise interventions for knee osteoarthritis, there is limited focus on patients with Grade 1 and 2 osteoarthritis. Understanding the most effective training method for this group will provide valuable insights for developing targeted rehabilitation programs, ultimately improving patient outcomes and quality of life. |
LAHORE UNIVERSITY OF BIOLOGICAL AND APPLIED SCIENCES | 2025-12-04 |
| 182 | Effect of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists on Subclinical Atherosclerosis in Non-diabetic Patients With Psoriatic Arthritis – A Proof-of-concept Randomized Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background Psoriatic arthritis (PsA) patients are at increased risk of cardiovascular disease. Glucagon-Like Peptide-1 (GLP-1) receptor agonists are cardiovascular protective in diabetics. They have also anti-inflammatory properties. It is hypothesized GLP-1 receptor agonists can prevent the progression of atherosclerosis due to the combination of metabolic factors and disease activity control in non-diabetic PsA patients. Objectives To investigate the vascular effects of GLP-1 receptor agonists in PsA patients without diabetes. Their metabolic and anti-inflammatory roles will also be examined. Design and subjects This is a pilot randomized open-labelled trial. We plan to enroll 40 non-diabetic patients with PsA. Participants will be randomized 1:1 to either GLP-1 receptor agonist (semaglutide) or control group. Study instruments Subclinical carotid artherosclerosis is assessed by high-resolution ultrasound. Arterial stiffness is measured using pulse wave velocity by a tonometry system, and augmentation index by the SphygmoCor device. These assessments will be done at baseline and 24 weeks. Drug adversities will also be documented. Anthropometric measurements, sugar metabolism and lipid levels as well as the PsA disease activity will be monitored. |
HO SO; | 2025-12-02 |
| 183 | Efficacy of Tofacitinib in Patients With Juvenile Idiopathic Arthritis: A Study Based on Real-world Clinical Practice Data PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate, using real-world clinical practice data, the efficacy of tofacitinib in improving the clinical control of juvenile idiopathic arthritis (JIA) after 12 months of treatment. |
ANDREA ZACARÍAS CROVATO; | 2025-11-26 |
| 184 | The Effect of Quadriceps Sets Exercise on Knee Joint Biomechanics and Functional Outcomes of Post-Total Knee Arthroplasty Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Lower limb strengthening, especially the quadriceps training, is of much necessity for patients with knee arthroplasty. As the quadriceps strengthening exercises play a vital role in controlling gait pattern during walking and different activities. Vastus inetrmedius muscle responsible for the last 10 degree of knee extension. This enable the knee joint to be in locked position which is the stable position during gait. |
ROKAIA ALI ZAINELABEDEEN MOHAMED TOSON; | 2026-03-10 |
| 185 | Rehabilitation Exercise Intervention for Rheumatoid Arthritis Patients Using Artificial Intelligence-Based Exercise Prescription System PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single-center, randomized, parallel-controlled trial evaluating the efficacy and safety of an artificial intelligence-based exercise prescription system for rehabilitation in rheumatoid arthritis (RA) patients. A total of 147 patients with low-to-moderate disease activity will be randomly assigned to three groups: AI exercise prescription group (personalized AI system guidance), paper exercise prescription group (traditional paper guidance), and routine care group. The intervention will last for 6 weeks with 6-month follow-up assessments evaluating joint function, pain, and quality of life indicators. |
PEKING UNIVERSITY THIRD HOSPITAL | 2025-11-24 |
| 186 | Efficacy of Resistance Exercise and An Anti-Inflammatory Diet on Pain, Disease Activity, Functional Status, and Quality of Life in Patients With Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to examine how resistance exercises and an anti-inflammatory diet affect pain, daily functioning, disease activity, and quality of life in people with rheumatoid arthritis. Participants will follow a structured exercise program and a diet plan designed to reduce inflammation. The study will measure changes in pain levels, mobility, overall health, and disease symptoms over time. The goal is to determine whether combining exercise and an anti-inflammatory diet can help improve the daily lives and well-being of individuals living with rheumatoid arthritis. |
BERRA YAMUÇ TANRIÖĞEN; | 2025-12-03 |
| 187 | Effect of Isometric Exercise Duration on Muscle Strength, Pain, and Function in Patients With Knee Osteoarthritis: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: this stuy tries to evaulate the best contraction (hold time) during isometric effort that can provide the best therapeutic effects on muscular performance in patients with knee osteoarthritis |
HISHAM MOHAMED HUSSEIN; | 2025-09-30 |
| 188 | A Comparative Study on Effects of Steroid, Dextrose Prolotherapy, and Platelet-Rich Plasma Injections to Lessen Pain in Knee Osteoarthritis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The novelty of thisstudy lies in its comparative assessment of three latest intra-articular injection therapies including steroid injections, dextrose prolotherapy, and PRP, for knee OA associated impairments, with a focus on long-term efficacy and safety profile. While prior studies may have assessed one or two of these treatments individually therefore this protocol is systematically designed. |
SHAHID SARWAR; | 2025-11-21 |
| 189 | Clinical Investigation of Sensovisc Sterile Sodium Hyaluronate Gel in The Hip Joint PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical investigation aims to investigate the safety and performance of Sensovisc.Sensovisc is used to reduce osteoarthritis related pain in the joints by supporting synovial fluid by intra-articular injection and allowing the synovial fluid to restore its viscoelastic properties. It increases the joint mobility by reducing or eliminating the pain. |
EMRE ADIGÜZEL; | 2025-11-18 |
| 190 | Clinical Investigation of Sensovisc Sterile Sodium Hyaluronate Gel in The Knee Joint PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical investigation aims to investigate the safety and performance of Sensovisc. Sensovisc is used to reduce osteoarthritis (OA) related pain in the joints by supporting synovial fluid by intra-articular injection and allowing the synovial fluid to restore its viscoelastic properties. It increases the joint mobility by reducing or eliminating the pain. This Clinical Investigation was designed as a cross-sectional, interventional, and prospective study. |
EMRE ADIGÜZEL; | 2025-11-20 |
| 191 | Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to test whether the addition of dextrose to perineural injections is superior to local anesthetic alone, as some initial data have indicated. To enhance the potential therapeutic effect, we will proceed to a 4-point injection technique, targeting 4 genicular nerves (superomedial, superolateral, inferomedial, recurrent peroneal genicular nerve) in a randomized controlled trial with two arms. |
KONSTANTINOS KALIMERIS; | 2025-12-02 |
| 192 | Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this observational study is to determine content of rare metals and other elements, along with the levels of selected immunological parameters, in the tissue of the hip or knee joint in the course of degenerative diseases. Determining potential disturbances in the levels or functions of these parameters may in the future contribute to improving treatment – for example, through supplementation of deficient metals or modulation at the immunological level. The main question it aims to answer is: Are selected rare metals, … |
MEDICAL UNIVERSITY OF WARSAW | 2026-01-16 |
| 193 | Precisión De La Osteotomía Tibial Proximal Con Instrumental Paciente-específico Vs Técnica Convencional PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a randomized clinical trial that will compare two surgical techniques for patients with knee osteoarthritis and varus deformity who are candidates for medial opening wedge high tibial osteotomy. The goal is to evaluate whether using patient-specific 3D-printed surgical guides improves the accuracy of the bone cut compared with the conventional technique performed with anatomical landmarks and fluoroscopy. A total of 50 adult patients will be randomly assigned to one of two groups: conventional osteotomy or osteotomy assisted by patient-specific instrumentation (PSI). The main outcome is the accuracy of the osteotomy cut, … |
ANTONIO I CUESTA-VARGAS; | 2026-04-03 |
| 194 | A Study to Evaluate The Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This is a study to demonstrate the long-term safety, tolerability and clinical efficacy of sonelokimab in the treatment of patients with psoriatic arthritis who completed a parental study (M1095-PSA-301 or M1095-PSA-302) |
MOONLAKE IMMUNOTHERAPEUTICS AG | 2026-03-27 |
| 195 | An Open-Label Exploratory Analysis of Commercial Probiotics in Adults With Rheumatoid Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical study is to collect data on the effect of probiotic administration on clinical outcomes in rheumatoid arthritis patients. Participants will: * Have a 6-week daily administration of a probiotic * Collect fecal samples every other day during the first 3 weeks of the study and twice weekly over the last 3 weeks * Visit the clinic at Baseline, Week 3 and Week 6 for checkup and testing |
ANCILIA BIOSCIENCES | 2025-12-31 |
| 196 | Phase I/IIa Study to Test The Safety and Efficacy of MSC From Umbilical Cord Tissue (UC-MSC) for The Treatment of Cartilage Damage in The Knee Joint PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Testing the safety and efficacy of MSC from umbilical cord tissue (UC-MSC) for the treatment of cartilage damage in the knee joint |
JÖRG LÜTZNER; | 2026-01-13 |
| 197 | Evaluation of The Effect of Agar And/or Collagen Based Compounds on Osteoarticular Pain. A Randomized, Parallel, Placebo Controlled, Triple Blind Clinical Trial (AGARTROSIS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Joints-comprising bone, cartilage, ligaments, and synovial fluid-enable stable daily movement but may deteriorate with age, excess body weight, overuse, injury, or disease. Such degeneration, common from age 40 onward, underlies joint disorders like osteoarthritis, particularly in the knees, hips, hands, and spine, and is a major cause of chronic pain and disability. While antiinflammatory analgesics remain the standard approach to symptom control, they neither cure disease nor regenerate cartilage and can produce significant long-term adverse effects (gastrointestinal, hepatic, renal, and cardiovascular). These limitations motivate interest in natural or complementary strategies with safer profiles. Within this context, marine algae, … |
ANTONI CAIMARI PALOU; | 2026-01-06 |
| 198 | The Effect of Cabbage Leaf Application on Pain, Physical Function and Quality of Life Levels of Patients With Knee Osteoarthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Among non-pharmacological treatment methods, herbal therapies are widely used, and cabbage leaves are recognized for their analgesic and anti-edematous effects. Previous studies indicate that patients often use cabbage leaves for breast engorgement and joint pain, and their strong antioxidant, anticancer, and anti-inflammatory properties have been demonstrated. This study aims to examine the effects of cabbage leaf application on pain, physical function, and quality of life in patients with knee osteoarthritis. This research is designed as an experimental, mixed-method, … |
SERAP PARLAR KILIÇ; | 2026-02-04 |
| 199 | A Randomized, Double-Blind, Placebo-Controlled, Single Dose Study to Assess The Safety and Efficacy of SL1002 Injectable for The Treatment of Knee Pain in Patients With Osteoarthritis of The Knee PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A Randomized, Double-Blind, Placebo-Controlled, Single Dose Study to Assess the Safety and Efficacy of SL1002 for the Treatment of Knee Pain in Patients with Osteoarthritis of the Knee. |
KRISHNAN CHAKRAVARTHY; | 2026-03-25 |
| 200 | Early Feasibility Study of Cartilage Defect Repair PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed conservative care, and is a candidate for surgical intervention to treat. |
JEFFREY NEPPLE; | 2026-02-17 |