Clinical Digest: Recent Clinical Trials on Attention Deficit Hyperactivity Disorder (ADHD) (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Attention Deficit Hyperactivity Disorder (ADHD). These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Attention Deficit Hyperactivity Disorder (ADHD) (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Effects of Physical Activity and Physical Fitness on Inflammation, Clinical Outcomes, and Quality of Life in Pediatric Inflammatory Bowel Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Pediatric inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic condition associated not only with intestinal inflammation but also with reduced physical fitness, fatigue, impaired quality of life, and psychosocial difficulties. Although physical activity and physical fitness are recognized as important determinants of health in the general pediatric population, their role as modifiable prognostic factors in children and adolescents with IBD remains insufficiently studied, particularly using objective measures and longitudinal designs in hospital settings. The present hospital-based study aims to investigate the effects of physical activity and physical fitness on inflammation, clinical outcomes, … |
CARLOS MARTÍN MARTÍNEZ; | 2026-03-24 |
| 2 | Comorbidity Between Attention Deficit Hyperactivity Disorder (ADHD) and Fibromyalgia: Cross-prevalence in Patients Treated for ADHD Who Are Naïve to Methylphenidate, ADHD Treated With Methylphenidate, or Fibromyalgia, and Associated Metabolomic Factors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The overall objective of the research project presented here is to assess the prevalence of fibromyalgia in patients being treated for ADHD, the prevalence of ADHD in patients being treated for fibromyalgia, and the neurobiological correlates of ADHD-fibromyalgia comorbidity. |
UNIVERSITY HOSPITAL TOURS | 2026-03-02 |
| 3 | Atomoxetine Effect on Attention, Executive Function, and Quality of Life in Veterans With Posttraumatic Stress Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Attention deficits (AD) frequently co-occur with posttraumatic stress disorder (PTSD). The presence of AD is associated with greater PTSD clinical severity and poorer clinical outcomes. Knowledge regarding the mechanism underlying this association is limited, though the emerging evidence has indicated that executive function deficit (EFD) is strongly correlated with AD and PTSD symptoms. While treatments developed for PTSD have existed for years, a substantial portion of individuals do not fully respond to conventional treatment. Accumulating evidence suggest that attention deficit (AD) and EFD may be a driving force for PTSD treatment resistance. However, … |
ZHEWU WANG; | 2026-02-12 |
| 4 | Non-progressive Congenital Ataxia – Advancing Diagnosis to Enhance Chances for Targeted Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This multinational European observational clinical study focuses on non-progressive congenital ataxia (NPCA), a very rare early-onset neurological condition also within the cerebral palsy (CP) concept as ataxic CP. The study aims to improve the diagnosis and care of affected children through a comprehensive approach that integrates detailed clinical assessments, brain imaging analyses, and advanced genetic testing. By identifying developmental trajectories, specific impairment profiles, brain MRI patterns, and genetic variants, the researchers aim to elucidate underlying mechanisms, … |
KATE HIMMELMANN; | 2026-02-19 |
| 5 | Supporting Expectant Mothers With ADHD Through The Transition to Parenthood: A Pilot RCT PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to test a behavioral program for pregnant individuals with ADHD. This behavioral program focuses on skills for managing ADHD and related symptoms in pregnancy and postpartum. This pilot effectiveness-implementation trial aims to (1) preliminarily evaluate the MomMA behavioral intervention compared to treatment as usual (TAU) on clinical outcomes and (2) evaluate implementation outcomes, including feasibility and acceptability of clinic screening within existing OB workflows; assessment and intervention protocols; provider training/fidelity to manual; and all other study protocols from the perspective of real-world providers and participants. |
HEATHER JOSEPH; | 2026-03-04 |
| 6 | Psychophysiological Responses to Six 15-Minute Single-Session Self-Regulation Interventions in A Female Adult With ADHD and Stabilized Bipolar Disorder: A Single-Case Study Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to explore how six short, 15-minute self-regulation techniques affect the body and brain in a female adult with ADHD and stabilized bipolar disorder. The techniques being tested include: * Aerobic exercise * Controlled breathing (cyclic sighing) * Aromatherapy with lavender essential oil * Listening to specific music (Solfeggio 528 Hz) * Virtual reality relaxation with forest imagery * Emotional Freedom Technique (EFT) tapping One session of quiet sitting with eyes open serves as a comparison. The participant will attend one 15-minute session per week for each technique. Before and after each session, … |
POZNAN UNIVERSITY OF PHYSICAL EDUCATION | 2026-02-27 |
| 7 | Evaluating The Effectiveness of A Virtual Reality Rehabilitation System (VRRS) Intervention on Executive Function Enhancement and Monitoring of Metaphonological Skills in ADHD Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Executive functions and metaphonological skills are closely interconnected in supporting language development and learning processes.Investigating this relationship could offer new insights into how executive and metaphonological skills interact, supporting the development of integrated intervention strategies targeting both cognitive and linguistic domains. This study aims to evaluate the effectiveness of a rehabilitation intervention using a virtual reality system (VRRS) in enhancing executive functions and monitoring metaphonological skills in children diagnosed with Attention Deficit Hyperactivity Disorder (ADHD).The aim is to explore whether a semi-immersive digital cognitive training protocol can lead to measurable improvements in executive functions, … |
IRCCS CENTRO NEUROLESI BONINO PULEJO | 2026-02-23 |
| 8 | ADHD&me: A Randomized Controlled Trial to Target Self-esteem in Youth With ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether the ADHD\&me (ADHD\&ik) intervention can improve self-esteem in youth aged 16-25 years with Attention Deficit Hyperactivity Disorder (ADHD). The ADHD\&me program is a cognitive behavioral therapy (CBT)-based intervention designed to help people with ADHD to develop a more positive view of themselves in their transition to adulthood. The main questions it aims to answer are: * Does the ADHD\&me intervention improve self-esteem in youth with ADHD, and are these effects maintained over time? * Does the intervention also improve related outcomes, … |
BIANCA BOYER; | 2026-03-31 |
| 9 | Symptoms of Sluggish Cognitive Tempo/Cognitive Disengagement Syndrome in Functional Neurological Symptom Disorder/Conversion Disorder: A Cross-Sectional Case-Control Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This cross-sectional observational case-control study aims to investigate symptoms of sluggish cognitive tempo (SCT), also known as cognitive disengagement syndrome (CDS), in adults diagnosed with Functional Neurological Symptom Disorder/Conversion Disorder (FNSD/CD). The study compares SCT/CDS symptoms between patients with FNSD/CD and healthy controls and evaluates their relationship with clinical variables. It is hypothesized that individuals diagnosed with FNSD/CD will exhibit higher levels of SCT/CDS symptoms compared to healthy controls. |
MEHMET HAMDI ÖRÜM; | 2026-03-09 |
| 10 | Identification of Neural Markers of Aggression and Irritability and Their Capacity to Predict Treatment Response to CNS Stimulant Medication in Youth With ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Impulsive Aggression and chronic irritability (IACI) often occur together and are one of the most common reasons children present for behavioral health (BH) care. ADHD frequently associated with IACI as upwards of 50% of youth with ADHD manifest impairing IACI levels. IACI is the most common reason that children with ADHD are prescribed antipsychotics and admitted to inpatient BH units. Systematic dose optimization of CNS stimulants improves levels of IACI, reducing the need for these more intensive and burdensome treatments. However, response varies, with over half of children with ADHD showing meaningful improvement, … |
JAMES WAXMONSKY; | 2026-03-16 |
| 11 | Effectiveness and Psychological Mechanisms of Group-based IMPROVE Therapy for Problematic Internet Use in University Students: A Single-blind Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Problematic internet use (PIU) is a growing behavioral health concern among university students. This study aims to evaluate the effectiveness and psychological mechanisms of IMPROVE, a manualized, multimodal group-based psychotherapy. The IMPROVE program integrates cognitive-behavioral strategies with motivational elements, mindfulness training, and socially interactive exercise. In this randomized controlled trial, 600 university students with moderate to severe PIU will be randomized to either the 8-week IMPROVE intervention or an enhanced waitlist control group. The primary outcome is the change in PIU severity, assessed by the Internet Addiction Test (IAT) score, from baseline to the post-intervention endpoint (8 weeks). |
YANHUI LIAO; | 2026-02-27 |
| 12 | Characterization of Social Cognition Profiles in Children and Adolescents With Neurodevelopmental Disorders: A Clinical Study Using A Multidimensional Battery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In France, more than one in ten school-aged children suffers from a mental health disorder, and half of these disorders appear before the age of 14. Yet, only half of affected children receive appropriate support. At the cognitive level, it is now widely accepted by the scientific community that strong socio-cognitive skills protect against the emergence of certain disorders. Social cognition skills, crucial for development and social integration, are often underestimated in clinical neuropsychology, … |
DOROTHÉE LEUNEN; | 2026-02-27 |
| 13 | Dense Cranial Electroacupuncture Stimulation Plus Body Acupuncture for Adolescents With Psychological Distress: A Randomized Controlled Trial With Observations on Salivary Oxytocin and Cortisol Changes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is an assessor-blinded, randomized, MAS-controlled trial. A total of 148 adolescents aged 15-22 years experiencing mild to moderate anxiety or depressive symptoms will be recruited. They will be randomly assigned to DCEAS+BA (n = 74) and MAS (n = 74) for 2 sessions per week for 8 weeks, followed by a 4-week post-treatment observation period. A post-intervention visit will be held at week 12. The primary outcome will be assessed using the Chinese version of the Beck Anxiety Inventory (BAI-C). The secondary outcomes include the Beck Depression Inventory II (C-BDI-II) for depression, … |
ZHANG ZHANG-JIN; | 2026-01-26 |
| 14 | Trauma Exposure and Suicidal Behaviors in Adolescents Aged 11-17 Hospitalized in Child and Adolescent Psychiatry PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: It is a comparative monocentric study with longitudinal follow-up at 6 months in adolescents aged between 11 years and 17 years inclusive admitted to complete hospitalization either for suicidal behaviors or for other psychiatric causes. The objective is to explore the experiences of hospitalized adolescents regarding hospitalization, as well as their perceptions of the factors involved in their remission and their experience of the traumatic event(s) if they have been exposed. |
UNIVERSITY HOSPITAL MONTPELLIER | 2026-02-24 |
| 15 | Randomised, Placebo-controlled Pilot Study to Assess The Effects of Probiotics on The Gut-brain Axis in Children With Attention Deficit Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The effect of probiotics on the gut-brain axis in children with attention deficit hyperactivity disorder will be studied. |
PROBI AB | 2026-03-10 |
| 16 | Study of The Nutritional, Inflammatory, and Metabolic Endophenotypes of Attention-Deficit/Hyperactivity Disorder (ADHD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to better understand the biological mechanisms involved in attention deficit hyperactivity disorder (ADHD) and to clarify why some children and adolescents respond well to methylphenidate (MPH)-the most commonly prescribed medication-while others do not. Although MPH is effective for many patients, a significant number experience limited benefits or problematic side effects such as appetite loss and sleep difficulties. Recent research suggests that inflammation and oxidative stress in the body may play an important role in ADHD. Some animal studies also indicate that MPH itself might trigger inflammatory processes, … |
UNIVERSITY HOSPITAL MONTPELLIER | 2026-02-18 |
| 17 | RestEaze: A Novel Wearable Device and Mobile Application to Improve The Diagnosis and Management of Restless Sleep in Pediatric Patients With Attention Deficit/Hyperactivity Disorder, Phase II PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if iron supplementation works to restless sleep in youth with ADHD. A second goal is to learn if iron supplementation helps to ease ADHD symptoms. The main questions that this trial aims to answer are: Does 3 months of iron supplementation treatment improve parent- … |
ALISON E PRITCHARD; | 2025-10-29 |
| 18 | Identification of Early Biomarkers of Pre-school ADHD: Pilot Study for The Development of A Clinical and Research Platform Dedicated to Early Detection and Intervention PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: ADHD affects around 5% of children and manifests itself as hyperactivity, attention difficulties and motor control and balance problems. The prevalence of ADHD is particularly high in certain populations, affecting up to 25-30% of children born prematurely and around 20% of children with neurological conditions such as epilepsy. This disorder is officially diagnosed from the age of 6, according to current criteria. However, its clinical manifestations appear much earlier, having a significant impact on all aspects of the child’s life, particularly in the most severe forms, which are often unrecognised due to a lack of clinical resources, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2026-02-27 |
| 19 | The Investigation of A Mindfulness-Based Intervention for ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Attention-deficit/hyperactivity disorder (ADHD) affects approximately 11% of children and adolescents in the United States. Individuals with ADHD experience substantial impairments and burdens across multiple areas of daily living, including peer difficulties, academic difficulties, poor job outcomes, high rates of co-occurring disorders, and large financial costs. Although there are many well-established, evidence-based treatments for ADHD, many children continue to experience significant impairment and elevated ADHD symptoms even with prolonged treatment. Further, there are several limitations to existing treatment approaches, including medication side effects, difficulty accessing behavioral treatments, and high out-of-pocket costs for behavioral treatments. Thus, … |
JAMES LYNCH; | 2026-03-31 |
| 20 | Improving Self-regulation, Social Participation, and Functional Performance in Individuals With ADHD Through Adapted Karate Training: A Randomized Controlled Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to examine the effectiveness of Adaptive Karate Training (AKT) in improving self-regulation and daily function in children with ADHD, exploring the underlying mechanisms. The main questions it aims to answer are: 1. Is the AKT more effective than no karate training in enhancing functional performance, self-regulation and school QoL? 2. Are poorer executive functions, emotional regulation, and sensory processing associated with higher gains? Researchers will compare two sequences: (1) A group receiving AKT followed by a no-intervention period; (2) A group receiving no intervention, followed by the AKT intervention, … |
TAMI BAR-SHALITA; | 2026-02-24 |
| 21 | Effects of Lactic Acid Bacteria in Patients With Attention-Deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to evaluate whether postbiotics supplementation can improve ADHD symptoms, such as mood and sleep, in children. Furthermore, salivary biochemical profiles will be analyzed and dietary habits will be recorded to further explore the effects and mechanisms of action of postbiotics. Research process: 80 subjects who meet the admission conditions will be recruited within three years after IRB approval. They will take the research capsules (postbiotics) in an open label design study and complete the 8-week intervention plus 4 weeks follow up trial period. |
I-CHING CHOU; | 2026-02-27 |
| 22 | Non-Invasive Neuromodulation As A Strategy for Reducing Occupational Stress and Burnout in Higher Education PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate if transcranial direct current stimulation (tDCS) works to reduce occupational stress and burnout in university professors. The main questions it aims to answer are: Does tDCS reduce levels of occupational stress in university professors? Does tDCS reduce burnout levels in university professors? Researchers will compare active tDCS to a sham stimulation (a look-alike procedure that contains no active stimulation) and a control group to see if tDCS effectively reduces stress and burnout. Participants will: * Complete questionnaires assessing stress and burnout levels before the intervention * Complete follow-up assessments immediately after the intervention and 5 weeks later During intervention, participans of active tDCS and Sham gruops will: * Receive 10 sessions of tDCS over 4 weeks (excluding weekends), 20 minutes each |
EGAS MONIZ COOPERATIVA DE ENSINO SUPERIOR CRL | 2026-02-20 |
| 23 | Evaluation of Long-term Efficacy of 4 to 6-month Course Antiviral Therapy for Neurodevelopmental Impairments Caused By Congenital Cytomegalovirus Infection: A Multicenter, Randomized, Controlled, Non-inferiority Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Title: Evaluation of Long-term Efficacy of 4-month versus 6-month Course Antiviral Therapy for Neurodevelopmental Impairment Caused by Congenital CMV Infection: A Multicenter, Randomized, Controlled, Non-inferiority Clinical Study 1\. Background and Rationale：Congenital cytomegalovirus (cCMV) infection is a leading cause of childhood neurodevelopmental disability and sensorineural hearing loss (SNHL). International guidelines, based on evidence from high-income countries, recommend a 6-month antiviral course for symptomatic infection. However, clinical practice in China lags significantly, … |
HU BOFEI; | 2026-03-04 |
| 24 | The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in The First Three Years in Children With Duchenne Muscular Dystrophy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the BABY DUCHENNE study is to evaluate the natural history and characterize the early clinical outcomes in very young children (0-3 years) with Duchenne muscular dystrophy (DMD) identified by newborn screening programs. |
BO HOON LEE; | 2025-12-15 |
| 25 | Effect of Adherence to A Gluten-Free Diet on Cognitive and Motor Dual-Task Performance in Adolescents Diagnosed With Celiac Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this cross-sectional observational study is to comprehensively examine the effects of adherence to a gluten-free diet on cognitive, motor, and psychosocial functions in adolescents aged 8-18 years diagnosed with celiac disease. In this context, dual-task gait performance, cognitive processing speed and attention, working memory and executive functions, muscle strength, quality of life, and fatigue levels of individuals with celiac disease who are adherent or non-adherent to a gluten-free diet will be compared with those of healthy peers. In addition, sleep patterns, pubertal development, socioeconomic indicators, … |
ZEYNAL YASACI; | 2026-02-03 |
| 26 | Implementation Strategies for Caregiver and Teacher Use of Behavioral Interventions: Aim 2 PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to pilot test for feasibility and initial promise an implementation strategy resource package that aims to support caregivers in using behavioral interventions for children with hyperactive, inattentive, or impulsive behaviors, when provided as an adjunct to a resource package for teachers. Participating children will be randomized at the classroom level to one of two conditions: a) their teacher and caregiver receive the resource package, or b) only their teacher receive the resource package. The research team will examine teacher and caregiver implementation outcomes and mental health outcomes for enrolled children. |
CHILDREN’S HOSPITAL OF PHILADELPHIA | 2026-02-05 |
| 27 | Improvement of Sustained Attention Through Immersive Virtual Reality in Neurodivergent Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to determine whether playing a virtual reality (VR) game can help neurodivergent children pay attention for extended periods. The study includes children ages 9 to 18 who have autism, ADHD, learning differences, or movement coordination challenges. The program lasts for 6 weeks. During this period, children will play a VR game twice per week, with each session lasting 25 minutes. |
NEW YORK INSTITUTE OF TECHNOLOGY | 2026-01-14 |
| 28 | Pregnancy and Viral Infections: Impact on Pregnant Women and Their Children. French Prospective Cohort. PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The VIROPREG study is a French prospective multicenter cohort study that aims to assess the impact of viral infections and antiviral treatments received during pregnancy on maternal and child health. The study focuses on both chronic viral infections: human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV)\] and on arbovirus infections. This study aims at investigating the following research questions: * What is the rate of mother-to-child transmission for each virus? * What are the effects of maternal infection on (i) pregnancy outcomes, (ii) the mother’s physical and psychological health, and (iii) the fetus’ health and development, … |
ANRS EMERGING INFECTIOUS DISEASES | 2026-02-17 |
| 29 | Improving ADHD Core Symptoms and Individual Quality of Life With Dietary APproaches Through Microbiota-Gut-Brain Signalling PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomised controlled trial is to evaluate whether a specific dietary intervention can reduce core symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in adults aged 18 to 50 years. The study also aims to understand how changes in diet may influence quality of life, neurocognitive function, and gut-brain signaling through the microbiota. The main questions it aims to answer are: 1. Does a high-fiber, fermented food-based diet reduce ADHD core symptoms over a 12-week period, as measured by the Conners’ Adult ADHD Rating Scale (CAARS)? 2. Does the diet improve neurocognitive function, mood, food reward, individual goals, … |
JOHN CRYAN; | 2026-02-12 |
| 30 | Comparing Medication Treatments for Neurodevelopmental Differences in Young Children on Rates of Beneficial Response PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This project will evaluate the effectiveness of Methylphenidate versus Guanfacine in treating Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 3 through 5 years (inclusive), as measured by clinician rating of global improvement. |
TANYA FROEHLICH; | 2026-01-07 |
| 31 | A Pharmaco-Imaging Trial of Mixed Amphetamine Salts for The Treatment of ADHD in Intellectually-intact Youth With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators are conducting a 10-week brain imaging and medication study. They are doing the research to study the response of Attention-Deficit/ Hyperactivity Disorder (ADHD) in youth with Autism Spectrum Disorder (ASD) on extended-release formulation of mixed amphetamine salts (MAS) (also know as Adderall XR). The investigators also want to find out if taking MAS has any effect on the brains of children and adolescents with ADHD and ASD. This study will help researchers better understand how the use of MAS to treat ADHD effects children and adolescents with ASD. The investigators will compare MAS to a placebo. The placebo will look exactly like the MAS capsules but will contain no MAS. During this study, participants may get a placebo instead of MAS. Placebos are used in research studies to see if the study results are due to the study drug or due to other reasons. Participants with ASD and ADHD will complete 4-weeks of treatment with the study medication or placebo. They will complete bi-weekly study visits virtually via a telemedicine platform with the study doctor and complete questionnaires. On alternating weeks, they will meet with a Massachusetts General Hospital (MGH) study team member to discuss medication adherence and potential side effects. Participants will have the option to attend all study visits in-person if participants prefer. They will also complete baseline and endpoint Magnetic Resonance (MR) scan visits at Massachusetts Institute of Technology (MIT). During the MR Scan visits, they will complete a series of tasks to measure inattention, impulsivity, reward sensitivity, decision-making, and working memory. Participants without ADHD or ASD will complete eligibility screening with MGH. If eligible, they will be invited to baseline and endpoint MR scan visits at MIT. During the MR Scan visits, they will complete a series of tasks to measure inattention, impulsivity, reward sensitivity, decision-making, and working memory. |
GAGAN JOSHI; | 2026-03-06 |
| 32 | A Randomized Controlled Trial of Executive Function Intervention for Children With Autism Spectrum Disorder(ASD) Combining Digital Application and Parent Coaching PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this randomized controlled study is to develop and evaluate a digital cognitive control intervention that integrates a digital application-based child training program with an online parent coaching program for early school-aged children aged 5-8 with autism spectrum disorder (ASD) and their caregivers in South Korea. This intervention is designed to enhance clinical applicability, sustainability, and generalization to daily life of executive skills through active parental involvement. This study has three primary aims: (1) to examine the feasibility, acceptability, and implementation fidelity of the integrated child-parent digital intervention, … |
SO HYUN KIM; | 2026-01-30 |
| 33 | Effectiveness of The SoundHeal (Heal) Multi-Sensory Integrative Therapy in Enhancing Emotional Regulation Among Justice-Involved Youth and Its Effect on Therapeutic Alliance and Mental Health Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Emotional dysregulation in justice-involved youth (JIY) is a condition that significantly impacts young people, their families, and juvenile justice and public health systems. Affecting an estimated 60-70% of detained Attention deficit hyperactivity disorderadolescents, it is a major driver of aggression, substance use, school failure, and later recidivism. Despite available treatments, managing emotional dysregulation in custody remains challenging, with youth often enduring high arousal, anger, and anxiety that persist into adulthood. Current popular therapies, including Cognitive Behavioral Therapy (CBT) and Dialectic Behavioral Therapy (DBT), often fall short in detention because they rely on verbal processing, require multiple scheduled sessions, … |
NISHAT BHUIYAN; | 2026-01-23 |
| 34 | Randomised Controlled Trial of A Cognitive, Emotional and Social Stimulation Programme for Socioeconomically Disadvantaged Children PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Latin America and the Caribbean exhibit high rates of poverty and social exclusion, where a significant portion of the population faces challenges in meeting basic needs. This socioeconomic vulnerability exacerbates environmental violence and its associated consequences. Recognizing that contexts of poverty and social exclusion can adversely impact children’s cognitive and emotional development, this research protocol aims to address these challenges. It proposes a cognitive and emotional stimulation program, complemented by an intervention targeting teachers and caregivers, grounded in neuroeducational principles. The overarching goal is to enhance children’s cognitive and academic performance, … |
JOAN DEUS YELA; | 2025-12-17 |
| 35 | The Effect of Dual-tasking Program on Cognitive and Physical Functions and Independence in Activities of Daily Living in Children With Duchenne Muscular Dystrophy: A Single-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and frequent developmental, cognitive and behavioral impairments, occurring in one in 5000 live births of boys. DMD is caused by a deficiency of the protein dystrophin, which maintains the structure and functionality of muscle cells. The absence of dystrophin leads to the weakening and eventual death of muscle cells, resulting in reduced muscle strength and impaired motor function. In early childhood, children with DMD may experience delays in basic motor skills such as walking and standing. Later in life, … |
BAŞAK ÇAĞLA ARSLAN; | 2026-01-27 |
| 36 | Digitizing and Automating The Diagnostic Psychiatric Assessment Process PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an observational study that will be responsible for the Spanish translation and cross-cultural adaptation, and validation of the Electronic Semi-Structured Psychiatric Interview for Children and Adolescents (EPSI-C), to examine, classify, prioritize, and diagnose patients. |
IRENE LOPEZ ARMENTEROS; | 2026-03-12 |
| 37 | The ADHD Kids´ Study: Randomized Clinical Trial on The OutSMARTers Program and Individual Counseling for Children Aged 9-12 With ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the study is to compare the efficacy of The OutSMARTers program- an ADHD skills training group program for children aged 9-12 to customized individual counseling provided by a professional, The Kid Counseling Program. Approximately 100 children will be randomly assigned to either intervention or a small wait-list group who will after a five-week-waiting period receive either intervention. Following the intervention, parents, children, and teachers will evaluate the effects on communication skills, well-being, and emotional regulation. |
DAGMAR KRISTÍN HANNESDÓTTIR; | 2026-01-30 |
| 38 | Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in Children With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To Determine the prevalence of ADHD symptoms in children with epilepsy, And find out the possible risk factors of ADHD in such patients and it’s effect on prognosis of the disease |
ASSIUT UNIVERSITY | 2025-10-03 |
| 39 | Augmenting Existing Normative Data for QbMobile in Healthy Children Aged 6-11 Years PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to strengthen the normative QbMobile data for children and adolescents age 6-11 years to allow for a more robust and accurate representation when comparing a patient’s QbMobile performance with the appropriate normative reference group. |
QBTECH AB | 2026-01-09 |
| 40 | An Examination of The Performance of QbMobile in Differential Diagnosis Associated With ADHD Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate QbMobile’s ability to collect objective data to identify specific symptom profiles in differential diagnoses (ASD, MDD, Bipolar Disorder and Anxiety Disorder) that are common with ADHD. |
QBTECH AB | 2026-01-09 |
| 41 | Landing Place: Impact of The Landing Place Mental Health App on Mental Health and Well-being PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if intervention with Landing Place mental health app can support wellness in college students. The main questions it aims to answer are: Can the app increased well-being in college students? Will the app have increased use and usability by the college students? Researchers will compare two groups of participants to see if the app intervention will increase wellbeing and app usability rates. Participants will randomly assigned into group 1 and 2. Group 1 will not use the app at all. Group 2 will use the app almost every day for 4 weeks. |
CHRISTOPHER SHELTON; | 2026-01-13 |
| 42 | Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM : Double Blind Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This double-blind, randomized, sham-controlled clinical trial will evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on children and adolescents with attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and matched healthy controls. Participants aged 6-19 years will be assigned to active or sham rTMS protocols targeting the dorsolateral prefrontal cortex over 3 weeks, with assessment of changes in disorder-specific symptoms and cortical excitability. The study aims to determine the safety, feasibility, and preliminary efficacy of rTMS as a non-invasive neuromodulation approach in pediatric neurodevelopmental disorders. |
AMAAL EMAD KHAIRY; | 2026-01-02 |
| 43 | Cognitive Benefit of Intensive Rehabilitation Using Rhythmic Music Training in Children With Complex Neurodevelopmental Disorder Related Papers Related Patents Related Grants Related Experts Highlight: In the wide range of studies carried out on neurodevelopmental disorders (NDD), rhythm disorders have been identified as a major cross-cutting component. The aim of our research is to evaluate the effect of intensive rhythm-based rehabilitation on rhythmic abilities and its generalization to attentional, executive and reading skills. |
UNIVERSITY HOSPITAL TOULOUSE | 2025-12-24 |
| 44 | The Effect of Monoallelic Variants in The ALPL Gene on The Natural Course of Hypophosphatasia (HPP) in Children and Adults in Russia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The effect of monoallelic variants in the ALPL gene on the natural course of hypophosphatasia (HPP) in children and adults in Russia (ATLANTIS) |
ASTRAZENECA | 2026-03-06 |
| 45 | Is The Disease Burden of Fibromyalgia Syndrome Higher in Mothers of Children With Attention-Deficit/Hyperactivity Disorder? A Prospective Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, the investigators aimed to evaluate the impact of having a child diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) on parental disease burden in mothers diagnosed with Fibromyalgia Syndrome (FMS). The study will include 50 mothers with FMS who have a child diagnosed with ADHD and 50 mothers with FMS who have children without any psychiatric disorders. Among mothers of children followed with a diagnosis of ADHD at the Child and Adolescent Psychiatry Outpatient Clinic of Edirne Sultan 1st Murat State Hospital, … |
ALPER MENGI; | 2026-01-12 |
| 46 | The Impact of Phenylalanine Elevations on Metabolic, Cognitive, and Neural Functioning in Adults Heterozygous for Phenylketonuria (PKU) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to advance our understanding of the cognitive and neurophysiologic sequelae associated with suboptimal phenylalanine (Phe) metabolism in heterozygous carriers of phenylketonuria (PKU). The main questions it aims to answer are: * Do PKU carriers experience prolonged elevations in brain Phe levels following oral ingestion of dietary Phe? * Do PKU carriers experience disruptions in cognitive functioning following oral ingestion of dietary Phe? * Do PKU carriers experience atypical brain activity following oral ingestion of dietary Phe? Researchers will compare PKU carriers and non-carriers following oral ingestion of dietary Phe and a placebo. Participants will: * Consume Phe or a placebo at two separate visits to our facility * At each visit, they will complete a series of MRIs and cognitive tests throughout the day |
SHAWN CHRIST; | 2026-03-11 |
| 47 | Understanding Mediating and Moderating Factors That Determine Transfer of Working Memory Training in Adolescents PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate how different approaches to executive function (like adding game-like features, varying the number of tasks, and providing coaching) can enhance executive function outcomes in adolescents with and without ADHD. The main questions it aims to answer are: * What components of executive function training contribute most to improving outcomes? * How do training components vary in their impacts on adolescents diagnosed with ADHD compared to those without a diagnosis? * What individual characteristics influence the effectiveness of executive function training? Researchers will test six different training setups to examine which setups are the most effective for different people. They will evaluate both how well participants follow the training schedule and whether there are changes in psychological and cognitive outcomes after training. Participants will complete: * 40 training sessions over 4 weeks * A set of tests and surveys before and after the training * Follow-up assessments and surveys 6 months after finishing the training |
AARON SEITZ; | 2025-12-23 |
| 48 | MEthylphenidate in ADHD – Addiction(s) Comorbidity: Value of Adding A Cognitive Remediation Program to Improve Short- and Medium-term Therapeutic Response PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: MEthylphenidate in ADHD – Addiction(s) comorbidity: benefit of adding a cognitive remediation program to improve short- and medium-term therapeutic response |
NANTES UNIVERSITY HOSPITAL | 2026-02-19 |
| 49 | Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates context-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, … |
KAI HWANG; | 2026-02-13 |
| 50 | Early Intervention After Traumatic Exposure in Children and Adolescents: A Randomized Controlled Trial of The Effectiveness of Child and Family Traumatic Stress Intervention (CFTSI) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this interventional research is to evaluate the effectiveness of CFTSI in reducing post-traumatic symptoms measured using the CPC, child version, at the end of CFTSI treatment in children and adolescents aged between 7 and 17 years, exposed to an ET in the last 3 months. The main question(s) it aims to answer \[is/are\]: * CFTSI reduces posttraumatic Child Posttraumatic Stress Checklist (CPC) scores in children exposed to ET, both immediatly after completion of the CFTSI and at 3 months after completion. * CFTSI reduces post-traumatic scores in parents on the PTSD Checklist for DSM5 (PCL), … |
UNIVERSITY HOSPITAL MONTPELLIER | 2025-10-03 |
| 51 | Evaluation of The Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Since early-onset preeclampsia (EOPE) is commonly associated with inadequate placentation, placental insufficiency, chronic fetal hypoxia, oxidative stress, and heightened inflammation, these pathological processes may adversely affect hippocampal neuronal development and maturation of axonal pathways such as the fornix. These mechanisms support our hypothesis that fetal fornix and hippocampus dimensions may be reduced in pregnancies complicated by EOPE, forming the scientific basis of our study. Previous research has suggested a potential link between preeclampsia (PE) and altered neurocognitive development. However, no studies to date have specifically evaluated the relationship between EOPE and fetal fornix or hippocampus dimensions. Therefore, … |
SEYIT AHMET EROL; | 2025-12-23 |
| 52 | Finding Alternatives to Standard Treatment for Attention-Deficit Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Attention-Deficit/Hyperactivity Disorder (ADHD) is characterized by poor attention, impulsivity, hyperactivity and emotional-motivational dysregulation. Here, we will test if theta burst repetitive transcranial magnetic stimulation (rTMS) can reduce the symptoms of ADHD. |
KARA MURIAS; | 2025-11-25 |
| 53 | The STIME Project: Intersectoral Prevention of Severe Youth Mental Health Difficulties PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial aims to evaluate the effectiveness of participation in five different STIME (Strengthened Cross-Sectoral Initiative for Children and Young People’s Mental Health) interventions: ‘Signs of Disordered Eating’, ‘Signs of Internalizing’, ‘Signs of Self-Harm’, ‘Take the Control Back’, and ‘The Parent Pilots’. The hypothesis is that participation in one of these interventions will be more effective than Management As Usual (MAU). Each intervention consists of three core components: early identification and screening, therapy based on evidence-informed manuals, and support within the child’s learning environment. |
CENTER FOR CLINICAL RESEARCH AND PREVENTION | 2026-02-17 |
| 54 | ADRIS Driving Simulator for Adolescents With Attention Deficit and Hyperactivity Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate a new driving simulator, called ADRIS 2.1, developed for adolescents aged 13-18 years with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a common neurodevelopmental disorder that can affect attention, self-control, and decision-making. These challenges may impact daily activities, including driving. The ADRIS simulator allows participants to drive in a virtual environment while their performance is monitored. The system measures driving errors (such as not stopping at red lights), head and body movements, and heart rate, … |
LINO NOBILI; | 2026-03-17 |
| 55 | Effects of Transcranial Photobiomodulation on Cognition and Brain Metabolism in Adults With ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators have previously shown that non-invasive methods of brain stimulation such as the administration of transcranial infrared light to the prefrontal cortex (PFC) can result in improvements to cognition and emotion as well as brain oxygenation. This method is called transcranial photobiomodulation (tPBM). The investigators hypothesize that tPBM can improve cognition and brain oxygenation in adults with attention deficit hyperactivity disorder (ADHD). The investigators will investigate the effects of repeated tPBM sessions on cognitive functioning in adults with ADHD. Specifically, the investigators hypothesize that participants that receive tPBM will show improvements in response control, sustained attention, and working memory, … |
FRANCISCO GONZALEZ-LIMA; | 2025-10-02 |
| 56 | Effects of A Six-Week Stroboscopic Training Program on Agility and Reactive Agility in Adolescent Male Basketball Players: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this pilot study was to investigate the effects of a stroboscopic training intervention on reactive agility and agility speed in basketball players, using identical movement patterns, and to evaluate perceptual-cognitive indices derived from the relationship between agility and reactive agility performance. This study hypothesized that stroboscopic visual training would significantly improve reactive agility and agility performance in adolescent male basketball players. |
BIRGÜL DINGIRDAN; | 2026-02-13 |
| 57 | Multidimensional Assessment of Mental Health in Adolescence: Cross-sectional Study Using Self-report and Parent-report Questionnaires PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Evidence indicates that many mental disorders in adulthood originate during adolescence, with a typical onset between the ages of 14 and 18, especially for anxiety, mood, and behavioral disorders. Over the past 20 years, the prevalence of psychiatric disorders among children and adolescents has increased globally, influenced by factors such as environmental stress, digital technologies, socioeconomic inequalities, and the consequences of the COVID-19 pandemic. Approximately one in seven adolescents worldwide suffers from a diagnosable mental disorder, with a growing trend, especially in high-income countries. A multidimensional and multi-informant assessment, integrating the perspectives of adolescents and parents, … |
IRCCS CENTRO NEUROLESI BONINO PULEJO | 2026-02-20 |
| 58 | A Multi-center, Prospective, Compared, Randomized, Evaluator-blinded, Pilot Study to Evaluate The Effectiveness of Digital Therapeutics ‘NDTx-02’ on Executive Function in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) or Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to explore the preliminary safety and effectiveness of the digital therapeutic device ‘NDTx-02’ in supporting improvements of executive function in children and adolescents diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) or Autism Spectrum Disorder (ASD). |
YOO-SOOK JOUNG; | 2025-11-21 |
| 59 | Examining The Effectiveness of A Dual Executive Function Training Package: Protocol for A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Executive function (EF) refers to the cognitive processes that enable goal-directed regulation of thoughts, emotions, and behaviours. Two interrelated domains are commonly distinguished: cool EF, which involves abstract cognitive processes, and hot EF, which involves regulation in emotionally or motivationally charged contexts. Children with special educational needs (SENs) frequently show difficulties across both domains, yet most interventions target one in isolation. The present study aims to evaluate the effectiveness of a dual EF training package for three of the most prevalent SENs groups: attention-deficit/hyperactivity disorder (ADHD), specific learning difficulties (SpLD), … |
EDUCATION UNIVERSITY OF HONG KONG | 2025-12-04 |
| 60 | Research on The Development, Implementation Effect and Neural Mechanism of A Physical Intervention Program for College Students With ADHD Based on The Characteristics of Balance Dysfunction PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Attention deficit/hyperactivity disorder is a common neurodevelopmental disorder. Its core symptoms and related executive function, emotional and motor coordination problems often persist into adulthood, significantly affecting the academic performance and quality of life of college students. Current drug interventions have limitations, while exercise interventions, especially training focused on balance ability, show potential in improving cognitive functions, … |
YANG LIU; | 2026-03-30 |
| 61 | Phase IIa Clinical Trial of External Trigeminal Nerve Stimulation for Autistic Children With Attention Deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if external trigeminal nerve stimulation (eTNS) works to treat ADHD symptoms in children on the autism spectrum (ASD). It will also learn about the efficacy and tolerability of the eTNS device. The main questions it aims to answer are: * Does eTNS reduce ADHD symptoms? * Does eTNS improve core and associated features of ASD? Participation spans 8-12 weeks and includes: * 4-5 in-person visits * 4 brief virtual check-ins * Nightly use of the eTNS device with a small sticky patch applied to child’s forehead * Randomized assignment (those who start with the sham device may try the active device later) |
JAMES T MCCRACKEN; | 2025-10-09 |
| 62 | Effectiveness of Neurofeedback in Treatment of Attention Deficit Hyperactivity Disorder in A Sample of Patients in Tanta, Egypt PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Attention-deficit/hyperactivity disorder (ADHD) is a common , chronic , and debilitating disorder . Although pharmacological treatments for ADHD can be easily implemented and are usually effective, their long-term therapeutic effects are still uncertain and adverse events are common, especially sleep problems, decreased appetite, and growth deceleration. Furthermore, psychosocial treatments, such eas parental training and behavioral therapy seem to be effective only during its delivery, … |
MAI AHMED SALEM; | 2025-12-16 |
| 63 | Gamma Transcranial Alternating Current Stimulation in Attention Deficit Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by symptoms of inattention, impulsivity, and hyperactivity. These symptoms are often associated with impairments in executive functions and working memory, which are essential for goal-directed behavior and cognitive control. Deficits in these domains can significantly hinder individuals’ academic, social, and daily functioning. Gamma oscillations (30-80 Hz) play a crucial role in cognitive integration, attention, and memory processes, … |
FATMA AYDIN; | 2025-08-28 |
| 64 | Combining L-theanine and Paraxanthine for Transient Improvement of Cognitive Deficits Among Patients With Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Series of Translational Pilot Neuroimaging Studies PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This pilot study will test whether combining L-theanine and paraxanthine improves sustained attention, inhibitory control, and overall cognition in adults with ADHD and ASD. Two parallel randomized, single-blinded, repeated-measures crossover trials will be conducted. Participants will complete neuropsychological testing, fMRI scanning, and self-report measures following administration of the L-theanine-paraxanthine combination compared to placebo. |
SAMUDANI DHANASEKARA; | 2026-02-05 |
| 65 | Effectiveness of Manual Therapy in The Treatment of Attention Deficit Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective is to determine whether Manual Therapy (MT), in addition to conventional treatment, is more effective in improving ADHD symptoms than the application of conventional treatment alone. |
JJ JIMENEZ-REJANO; | 2025-06-27 |
| 66 | Comparing Psychosocial Supports for Adolescents With ADHD: What Works Best for Whom and Why? PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized control trial comparing Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) among adolescents with a pre-existing ADHD diagnosis presenting to the Duke ADHD Program. Both treatments are eight 90 minute sessions. The research component will involve a pre-treatment assessment and post-treatment assessment. Both assessments will involve adolescents and one caregiver to complete questionnaires over REDCap. Rating scales will include ADHD symptom severity (Conners 3: self and parent report), functional impairment (IRS: self and parent report), executive functioning (BRIEF-2: parent report), emotion dysregulation (DERS: self and parent report), trait mindfulness (FFMQ: self report), organizational skills (BRIEF-2: parent report), … |
MARGARET SIBLEY; | 2025-12-15 |
| 67 | Evaluation of The LUSHA Digital Application for Children With ADHD (Attention Deficit Hyperactivity Disorder) Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Attention Deficit Disorder with or without Hyperactivity (ADHD) is a neurodevelopmental disorder characterized by a triad of symptoms combining inattention, hyperactivity, and/or impulsivity. It causes developmental and functional disturbances (cognitive, behavioral, and emotional) that have a detrimental impact on the child’s family, school, and/or social life. Treatment requires psychoeducation for the child and their parents, individual treatment for the child, and finally family treatment, particularly through specific parenting skills training programs (such as the Barkley program, 1997). It is sometimes necessary to combine this with medication (psychostimulants). This care pathway can be complex to implement in practice, … |
BIOULAC STÉPHANIE; | 2025-10-02 |
| 68 | Effects of The Use of An Immersive Virtual Reality Device on Handwriting in Children Aged 6 to 13 With Handwriting Difficulties : A Randomized Multiple Baseline Single-case Experimental Design (SCED) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Difficulties in learning to write affect a large number of children and can have a significant impact on their personal and professional future. To facilitate this learning process, develop fun, motivating and effective devices for the different skills involved in writing (motor skills, postural control, visual attention, letter recognition) is needing. Virtual Reality (VR) seems to be a promising tool for this purpose. The SCED (Single Case Experimental Design) methodology is adapted to this study to evaluate the impact of VR on learning to write, … |
JÉROMINE HERVO; | 2025-12-24 |
| 69 | Transcranial Photobiomodulation With Multiple Interventions in Children With Attention-Deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To investigate the therapeutic efficacy of transcranial photobiomodulation (tPBM) with multiple interventions in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). The study evaluates intervention effects at Magnetic Resonance Imaging, electrophysiological, Visual Search Task, cognitive-behavioral, and clinical symptom levels, aiming to identify the optimal clinical treatment regimen for ADHD patients. |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2025-10-06 |
| 70 | Assessing Real Life Effectiveness of Treatment in Neurodevelopmental Disorders PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn if and how pharmacological and psychotherapeutic group treatments can treat clinical symptoms of children and adolescent patients with ADHD. The main questions it aims to answer are: * Are pharmacological and psychotherapeutic treatments effective on the clinical symptoms of patients with ADHD? * Are pharmacological and psychotherapeutic treatments effective on symptoms of emotion-behavioral dysregulation? * Is it possible to find associations between individual characteristics and treatment responses evaluating behavioral and neural correlates in children and adolescents with traits of emotion-behavioral dysregulation, externalizing disorders, and/or ADHD, … |
MARIA NOBILE; | 2025-12-09 |
| 71 | Pilot Comparative Efficacy Randomized Controlled Trial of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) for Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized control trial comparing Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) among adolescents with a pre-existing ADHD diagnosis presenting to the Duke ADHD Program. Both treatments are eight 90 minute sessions. The research component will involve a pre-treatment assessment and post-treatment assessment. Both assessments will involve adolescents and one caregiver to complete questionnaires over REDCap. Rating scales will include ADHD symptom severity (Conners 3: self and parent report), functional impairment (IRS: self and parent report), executive functioning (BRIEF-2: parent report), emotion dysregulation (DERS: self and parent report), trait mindfulness (FFMQ: self report), organizational skills (BRIEF-2: parent report), … |
JOHN MITCHELL; | 2025-10-20 |
| 72 | A Phase 3, Multicenter, Open-label, Uncontrolled, Long-term Japan-China Joint Trial to Evaluate The Safety and Efficacy of EB-1020 QD XR Capsules Administered Orally Once Daily in Children and Adolescents With Attention- Deficit/Hyperactivity Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety of long-term administration of mainly high doses of EB-1020 over 52 weeks in pediatric ADHD patients. |
OTSUKA PHARMACEUTICAL | 2025-12-23 |
| 73 | Functional Connectivity of The Interoceptive Network in Restless Legs Syndrome (RLS) : An Anatomical-clinical Prospective Study Based on Daily-life Assessment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Restless Legs Syndrome (RLS) is a sensorimotor disorder primarily characterized by an irresistible urge to move the legs while at rest. A key hypothesis suggests that RLS symptoms are linked to abnormal brain function in processing internally generated stimuli, particularly interoception. This distorted perception of the internal bodily state leads to maladaptive behaviors, which may manifest across a wide range of medical and psychiatric disorders. Here, the investigators hypothesize that dysfunction in the insular cortex (IC) may result in a failure of behavioral adaptation, primarily expressed as an urge to move the legs and hyperarousal, … |
IMAD MARC ANTOINE GHORAYEB; | 2025-09-17 |
| 74 | Prevalence of Neurodevelopmental Disorders in A Homeless Population – Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction \& Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder). Methods / approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, … |
CAROLINE DEMILY; | 2025-08-01 |
| 75 | Improving ADHD Teen Driving – Virtual Reality PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Teens with Attention-Deficit/Hyperactivity Disorder (ADHD) have high rates of negative driving outcomes, including motor vehicle crashes, which may be caused by visual inattention (i.e., looking away from the roadway to perform secondary tasks). Two versions of a driving intervention that trains teens to reduce instances of looking away from the roadway will be tested in teens with ADHD. |
JEFF N EPSTEIN; | 2026-02-23 |
| 76 | Development of A Novel Virtual Reality Treatment for Emerging Adults With ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this larger parallel group randomized trial is to test the impact of a virtual reality program for improving the ability of emerging adults (age 18-25) with attention deficit hyperactivity disorder (ADHD) to stay focused while completing homework and studying. This study compares the impact of using a virtual reality headset to using a virtual reality headset while also receiving feedback about levels of focus to a control group. The main question is whether participants demonstrate significantly improved concentration while completing homework and studying in virtual reality and whether they enjoy and prefer working in a virtual reality environment. Concentration is measured both through participant report and also using keyboard and mouse click data to assess work productivity objectively. |
JOSHUA M. LANGBERG; | 2026-01-28 |
| 77 | Effects of ITBS on Cognitive Control in Children With ADHD: A Randomized, Sham-Controlled Study Integrating EEG During ANT, FNIRS, MRI, and Genetic Markers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if brain stimulation can help children ages 6 to 12 with attention-deficit/hyperactivity disorder (ADHD) improve their attention and self-control. The main questions it aims to answer are: Does intermittent theta burst stimulation (iTBS) improve performance on a task that tests attention and reaction times? Can brain activity and genetics help predict who benefits most from this treatment? Researchers will compare randomly assigned active iTBS to sham (inactive) stimulation groups to see if the treatment helps. Participants will: Receive 10 sessions of either active or sham iTBS over 2 weeks Complete a computer task measuring attention before and after stimulation Wear a brain cap during the task to record EEG signals, also take part in resting-state brain scans, namely magnetic resonance imaging (MRI) and functional near-infrared spectroscopy (fNIRS), and provide a saliva sample for genetic testing |
NEUROLAB PLUS | 2025-09-19 |
| 78 | A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-controlled, Japan-China Joint Trial to Evaluate The Efficacy and Safety of Two Dose Levels of EB-1020 QD XR Capsules Administered Orally Once Daily in Children and Adolescents With Attention-deficit/Hyperactivity Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the efficacy and examine the safety of two doses of EB-1020 QD XR capsule administered once daily orally in pediatric ADHD patients. |
OTSUKA PHARMACEUTICAL | 2025-12-23 |
| 79 | Testing A Brief, Engagement Focused Intervention for Parents and Educators in Preschool: Parent-Educator Action Response PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if a new adjunctive intervention, Parent-Educator Action Response (PEAR), works to improve teacher and family engagement in school-based interventions for child attention deficit/hyperactivity disorder (ADHD) and disruptive behavior symptoms. This clinical trial will also be used to refine implementation procedures to inform a larger clinical trial. |
COURTNEY ZULAUF-MCCURDY; | 2025-11-04 |
| 80 | Reducing Smartphone Overuse for Adolescents With Attention-Deficit Hyperactive Disorder: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will develop and evaluate a smartphone-based behavioral intervention for adolescents with Attention-Deficit Hyperactive Disorder (ADHD) and smartphone overuse in Hong Kong. The main questions it aims to answer are: * Can a smartphone-based intervention lower self-reported smartphone dependence and objective smartphone usage? * Can a smartphone-based intervention lower parent-rated and self-rated ADHD symptoms? * Are there differences in electroencephalogram (EEG) in the smartphone salient vs smartphone non-salient conditions after intervention? Adolescent participants will: * report weekly smartphone use patterns based on app screencap for 12 weeks * complete online surveys on smartphone dependency and ADHD symptoms for 3 times * receive 10-minute EEG recordings to gather resting-state EEG data in a natural and relaxing state for 3 times Parent participants will: * provide a valid clinical report to confirm the adolescent’s diagnosis of ADHD * complete online surveys to report on the adolescent’s smartphone usage and ADHD symptoms for 3 times |
YUM YEN NA CHERRY; | 2025-07-30 |
| 81 | Certified Comprehensive Eye-Movement Examination in Children With Attention Deficit Hyperactivity Disorder: An Objective, Reproducible and Quantitative Diagnosis in 15 Minutes? PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Attention Deficit Hyperactivity Disorder (ADHD) affects more than 5 % of children and adolescents, with a globally increasing prevalence. The condition imposes a significant burden on affected individuals, their families, and healthcare systems. Early and accurate diagnosis is crucial to ensure timely therapeutic and educational interventions. However, current diagnostic practices rely heavily on clinical interviews and behavioral observations, which are inherently subjective and resource-intensive. There is a growing need for objective diagnostic tools that can complement or even partially replace current clinical assessments. One promising approach involves eye-tracking technology, … |
ONOVIS AUGENPRAXIS | 2025-08-22 |
| 82 | Where Wild Things Grow: Immediate and Long-term Impact of Nature- and Activity-based Group Interventions for Neurodivergent Children and Youth in School, Health Care and Leisure Settings in Agder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this action research project is to develop and implement nature- and activity-based group interventions across health care, school and leisure settings in Southern Norway. The interventions are tailored to support the mental health, self-efficacy and daily life functioning of children and youth in the Agder region, with a particular focus on youngsters who struggle due to neurodivergence, such as Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) or Tourette’s syndrome. The main questions we aim to answer are: 1. To what extent does nature- … |
CARINA R FERNEE; | 2025-10-02 |
| 83 | Monitoring Neurocognitive Dysfunction and The Impact of Metabolism and Physical Capacity After Paediatric Haematopoietic Stem Cell Transplantation (Abbreviation: MindMe) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Today the overall survival of childhood cancers has increased to above 85%. This increase is partially caused by treatment with bone marrow transplantation. A bone marrow transplantation is an efficient treatment against high-risk leukemia, as well as other life-threatening immunological and hematological diseases. However, it is unfortunately also related to the risk of developing a long series of late effects during early adulthood, such as reduced muscle mass, cardiovascular disease and diabetes. Some survivors of bone marrow transplantation in childhood also seem to experience changes in cognitive functions. These changes may be experienced as difficulties with concentration, forgetfulness, learning difficulties, … |
HILDE HYLLAND UHLVING; | 2025-09-04 |
| 84 | Intelligence and Neurodevelopmental Outcome After Prenatal Exposure to Labour Epidural Analgesia: A Sibling Matched Clinical Ambidirectional Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In Belgium, labour epidural analgesia (LEA) has been used for decades in the vast majority of vaginal deliveries (up to 83% of deliveries). Labour epidural analgesia is the most effective and safest way to allow pregnant women a nearly pain-free labour- and birth experience. Recent data showed that the use of LEA was associated with a reduced risk for severe maternal morbidity, neonatal resuscitation and with a reduced risk for low Apgar scores. However, prenatal exposure to labour epidural analgesia has been associated by several study groups with an increased risk for autism spectrum disorder (ASD) in the children, … |
UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN | 2025-06-11 |
| 85 | Bridging The Gap in The Study of Bipolar Disorder and Attention Deficit Hyperactivity Disorder: Impact of CognitiVE Reserve and FunCtioning in A Newly Designed Treatment IntervenTion for ComORbidity (VECTOR) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cognitive dysfunctions are present in Bipolar Disorder (BD) and Attention Deficit Hyperactivity Disorder (ADHD) and may negatively impact psychosocial functioning. Further, comorbid BD and ADHD (BD-ADHD) is prevalent, associated with an earlier BD onset and a less favorable prognosis. Nevertheless, … |
CARLA TORRENT; | 2025-06-26 |
| 86 | PHArmaCokinetics of MethYLphenidate in Adult Patients With Attention-Deficit /Hyperactivity Disorder: Comparison Between Patients With and Without OBesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: PHACYLOB PHArmaCokinetics of methYLphenidate in adult patients with Attention-Deficit Hyperactivity Disorder (ADHD) : comparison between patients with and without OBesity. Its aim is to determine whether, for a comparable treatment dose, there are differences in the pharmacokinetic of methylphenidate between ADHD patients with obesitý and ADHD patients but without obesitý. More specifically, we will assess whether blood concentrations of methylphenidate (MPH; long acting form) are significantly higher or lower in either group at different times of the day. To meet this objective, … |
UNIVERSITY HOSPITAL TOURS | 2025-08-13 |
| 87 | Evaluation of The Effectiveness of Day Hospital Care for Adolescents With Anxious School Refusal PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of the study is to evaluate the benefit of day care in a child psychiatric hospital on the return to school and on the development of child psychiatric disorders associated with Anxious Social Refusal. |
GCS RAMSAY SANTÉ POUR L’ENSEIGNEMENT ET LA RECHERCHE | 2025-06-13 |
| 88 | Investigation of Differences in Dual and Single Motor and Cognitive Tasks of Children With Attention Deficit and Hyperactivity Disorder Compared to Healthy Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: When motor control deficits, sensory-perceptual deficits, and deficits in attention allocation and executive functions, often seen in ADHD, are accompanied by impairments in attentional allocation and executive function, further difficulties with dual tasks may arise. The aim of this study was to compare the performance of children diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) with healthy children on single-motor and dual-motor and motor-cognitive tasks. |
ZEKIYE İPEK; | 2025-12-12 |
| 89 | Accelerated ITBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this project is to examine the differential therapeutic effect of intermittent theta burst stimulation (iTBS; a type of repetitive transcranial magnetic stimulation) to the left DLPFC versus right PreSMA in modulating working memory (WM) versus inhibitory control (IC) deficits. Fifty adolescents (12-18 years old) with parent-reported WM and IC deficits and diagnosed ADHD will be randomized to DLPFC or PreSMA targeted 3x-daily iTBS for a total of ten days (30 total sessions). |
BRADLEY HOSPITAL | 2025-10-22 |
| 90 | Healing Minds II: Biofeedback, Breathing Practices, Nutrition and Exercise Counseling in Children and Adolescents With ADHD Related Papers Related Patents Related Grants Related Experts Highlight: The Pediatric Healing Minds II intervention includes a biofeedback component, breathing practices nutrition and exercise counseling. Biofeedback is a type of mind-body technique used to control body functions such as heart, lung and muscle responses. Biofeedback uses therapeutic techniques that aim to help study participants gain more awareness and control over certain physiological functions in their bodies. It involves the use of electronic monitoring equipment to provide real-time information about physiological processes such as heart rate, HRV, coherence and muscle tension. This information is then provided back to the study participant, … |
INARA MCMASTER; | 2026-01-28 |
| 91 | ADAPT: Approach to Dance for Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: It is well documented that motor impairments are associated with a diagnosis of autism spectrum disorder (ASD). Yet, appropriate therapies are scarce. Dance has been shown to not only promote fine and gross motor skills, but also psychological well-being, cognition, and social participation in neurotypical dancers. Little research has been conducted to gauge if these benefits translate to those with ASD. Ballet for all Kids (BFAK) is a recreational dance program that has been teaching ballet to children with ASD for over a decade, … |
ALEXANDER KOLEVZON; | 2025-10-15 |
| 92 | EFFECT OF PERCEPTUAL-MOTOR TRAINING ON COGNITIVE FUNCTIONS, MOTOR ABILITIES AND QUALITY OF LIFE IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVE DISORDER PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to Determine the effect of perceptual-motor training on: cognitive functions, motor abilities, and quality of life in ADHD children. |
HEBATALAH KHODAIR KAMAL ABD_EL_MAGEID; | 2026-03-31 |
| 93 | DBT Skill Training for Autistic Adults With Difficulties in Emotion Regulation: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: One in 44 has autism, 70% of them have additional mental health challenges. Currently, this patient population does not have access to effective treatment within specialist healthcare services and has struggled to benefit from standard treatments. The goal of this project is to increase access to treatment tailored to their challenges. We will investigate whether a treatment program with an adapted version of Dialectical Behavior Therapy (DBT) is feasible, accepted, and perceived as useful for people with autism. The purpose of the treatment is to improve emotion regulation, function better in relationships, and avoid crises, … |
HELSE MØRE OG ROMSDAL HF | 2025-07-15 |
| 94 | M.I.N.E.R.V.A., Metodologie Innovative Per La Neuroplasticità in Età Evolutiva Con L’Uso Della Realtà Virtuale A Scopo Abilitativo PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Neurodevelopmental disorders, such as Cerebral Palsy (CP), Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), are complex conditions that affect various aspects of children’s development. Despite advancements in treatments, conventional rehabilitative interventions tend to focus on specific aspects, often overlooking the holistic needs of the patient. Many of these interventions fail to engage children, who may feel uninvolved or demotivated. Innovative technologies, such as immersive virtual reality (IVR), offer a promising alternative to make rehabilitation more engaging and comprehensive. This study aims to evaluate the effects of IVR-based rehabilitation on children and adolescents with neurodevelopmental disorders, focusing on improvements in cognitive, … |
IRCCS CENTRO NEUROLESI BONINO PULEJO | 2026-02-23 |
| 95 | A Phase Ib, Multicentre, Randomised, Double Blind, Placebo Controlled, 2 Sequence Crossover Trial to Evaluate The Effects of BI 3031185 on Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics in Patients With Borderline Personality Disorder or Attention-deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is open to adults with borderline personality disorder (BPD) and with attention deficit/ hyperactivity disorder (ADHD). The purpose of this study is to find out how a medicine called BI 3031185 is tolerated by people with BPD or ADHD. Participants with BPD with ADHD are in separate cohorts. Participants from each cohort are put into 2 groups of equal size randomly, which means by chance. Group 1 takes a single dose of BI 3031185 and Group 2 takes placebo. After a 2-week break, … |
BOEHRINGER INGELHEIM | 2026-04-03 |
| 96 | Scalp Acupuncture Treatment for Chronic Tic Disorders in Children: A Multicenter Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if scalp acupuncture works to treat chronic tic disorders (CTD) in children. It will also learn about the safety of scalp acupuncture. The main questions it aims to answer are: * Does scalp acupuncture improve clinical symptoms and social functioning, … |
HAO ZHOU; | 2025-07-23 |
| 97 | Metacognitive Intervention in Children and Adolescents With ADHD – MiA Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the MiA-Study is to address the current lack of effective treatment options to reduce cognitive and physical long-term problems in children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD). Through the use of the Mio-Training, cognitive development will be strengthened and metacognitive thinking and awareness will increase. The MiA-Study is conducted additionally to the Mio-study to evaluate the effectiveness of the Mio-Training specifically within the ADHD population. The Mio-Training for children and adolescence with ADHD includes a combination of cognitive and coordinative training tasks and prospective as well as retrospective metacognitive questions. In a randomized controlled trial, … |
REGULA EVERTS; | 2025-09-09 |
| 98 | A Double-Blind, Sham-Controlled Trial Investigating Individualized Alpha Neurofeedback Plus Cognitive Training in Paediatric Brain Tumour Survivors PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Brief Summary of the Study: This study is a prospective, randomized, sham-controlled, triple-blind trial investigating whether combining individualized alpha neurofeedback (NF) with cognitive training (Cogmed) can improve cognitive functioning in pediatric brain tumor survivors (PBTS), a group at risk for persistent cognitive difficulties after cancer treatment. Participants (ages 6-18) who have completed primary cancer therapy and report cognitive problems are randomly assigned to either (1) individualized alpha NF plus Cogmed or (2) sham NF plus Cogmed. Both interventions include eight one-hour sessions over four weeks, … |
WINNIE WAN YEE TSO (DR); | 2026-01-27 |
| 99 | Evaluating The Feasibility and Tolerability of A Digital Cognitive Training Intervention in Adults With ADHD: A Randomized, Placebo-controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether a digital cognitive training program can reduce symptoms of ADHD, improve executive functioning, and decrease problematic internet use in adults aged 18-65 with a diagnosis of moderate to severe ADHD. The main questions it aims to answer are: Can digital cognitive training improve executive function, … |
MCMASTER UNIVERSITY | 2025-07-22 |
| 100 | Implementation Strategies for Caregiver and Teacher Use of Behavioral Interventions With ADHD: A Pilot Study, Aim 1 PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to field pre-test an implementation strategy resource package that aims to support caregivers in using behavioral interventions for children with hyperactive, inattentive, or impulsive behaviors. Enrolled caregivers will be assigned to use the resource package with their children. The research team will collect quantitative and qualitative data regarding acceptability, appropriateness, and feasibility, in preparation for a randomized pilot study. |
GWENDOLYN M LAWSON; | 2026-01-26 |
| 101 | Evaluating A Spanish-language Executive Functioning Intervention for Children With Autism And/or ADHD and Their Families PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether the Spanish-language version of Unstuck and On Target (SL-Unstuck), an executive functioning (EF) intervention, is feasible, acceptable, and effective for Spanish-speaking caregivers and their neurodivergent children (ages 8-11) in the U.S.. The main questions it aims to answer are: * Is SL-Unstuck acceptable to Spanish-speaking caregivers and children? * Does SL-Unstuck improve child EF, caregiver EF knowledge, … |
JONATHAN SAFER-LICHTENSTEIN; | 2026-04-03 |
| 102 | The Effect Of Methylphenıdate Treatment On Neuroınflammatıon Levels In Chıldren Wıth Attentıon Defıcıt Hyperactıvıty Dısorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to investigate the effect of treatment of ADHD with methylphenidate on neuroinflammation by examining the levels of Interleukin-6 (IL-6), S100B, Claudin-5 in serum samples of patients who were diagnosed with attention deficit hyperactivity disorder (ADHD) and started or planned to start methylphenidate for treatment as per routine, at month 0 before the initiation of methylphenidate treatment and at month 3 after the initiation of treatment. |
ENES FARUK ALTUNKILIÇ; | 2026-02-24 |
| 103 | A Phase 3, Multicenter, Open-label, Uncontrolled, Long-term Trial to Evaluate The Safety and Efficacy of Long-term Administration of EB-1020 Once Daily QD XR Capsules in Adults With Attention-deficit/Hyperactivity Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety of long-term administration of mainly high doses of EB-1020 over 52 weeks in patients who have completed the double-blind trial (405-102-00112) conducted in Japan |
OTSUKA PHARMACEUTICAL | 2025-04-15 |
| 104 | A Phase IV, Randomized, Placebo-Controlled, Double-Blind Study to Assess The Effectiveness and Safety of Clonidine Extended-Release (OnydaTM XR) in Children Aged 6 to 12 Years With Attention-Deficit/ Hyperactivity Disorder and Oppositional Defiant Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a study to see how safe and effective OnydaTM XR is to treat Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 6 to 12 years who also have Oppositional Defiant Disorder (ODD). The trial will consist of a screening period of up to 28 days; a 35-day double-blind treatment period that includes a one week of the lowest dose of medication (0.1mg) given at bedtime, then three weeks at 0.2 mg, then one week at 0.1 mg and a follow-up phone call one week after stopping study medication. During the screening period, … |
ANN CHILDRESS; | 2025-07-01 |
| 105 | Brain STimulation for ANxiety and Depression in Youth: Brain STAND PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this open-label trial, the overall aim is to determine if TMS treatment can improve anxiety and depression in a broad group of children and youth referred by physicians. |
KARA MURIAS; | 2026-01-29 |
| 106 | Investigation of The Effect of Virtual Reality on Cognitive Skills in Children With Attention Deficit Hyperactivity Disorders PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the effects of virtual reality (VR) intervention on cognitive skills in children with attention deficit hyperactivity disorder (ADHD). |
LEYLA KAYA OZTURK; | 2025-09-29 |
| 107 | Verification of The Effects of A Mindfulness-based Online Training Program for Recovering From Cognitive Decline Related to Maltreatment Experiences PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to examine whether an online mindfulness-based training program can help improve cognitive function including attention, emotional regulation, and mental health (such as depression and anxiety) in young adults (ages 19 to 40) who have experienced maltreatment. The main questions it aims to answer are: * Can a 4-week online mindfulness program improve cognitive function including attention in adults with a history of maltreatment? * Does the program reduce symptoms of depression and anxiety compared to a control group? Researchers will compare a mindfulness training group with a waiting-list control group to see if the intervention leads to improvements in psychological and cognitive functioning. Participants will: * Complete psychological and cognitive assessments before and after the 4-week period * Watch weekly online educational and mindfulness practice videos (e.g., breathing, body scan, walking meditation) * Perform weekly mindfulness-based assignments through a study website * Engage in optional interaction via a chat channel |
SANG WON LEE; | 2025-07-15 |
| 108 | Examination of The Dynamic Relationships of Sleep, Physical Activity, and Circadian Rhythmicity With Neurobehavioral Heterogeneity in ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Attention deficit/hyperactivity disorder (ADHD) can present differently in individuals, with some individuals having difficulty with attentional control, hyperactivity, impulsivity, emotion dysregulation, and/or neurobehavioral functioning. The factors contributing to these different presentations remain unclear, but altered patterns of physical activity, sleep, and circadian rest/activity rhythms may play a key role. The goal of this study is to leverage wearable technology (i.e., a wristband) to investigate the relationships between physical activity during the day, sleep patterns and disturbances, and 24-hour circadian rest/activity rhythms with differences in ADHD symptoms, emotion dysregulation, … |
KERI ROSCH; | 2026-03-09 |
| 109 | Scalable, Clinician-Supervised Generative-AI Food-Chaining Assistant for Pediatric ARFID: A Pilot Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Children with Avoidant/Restrictive Food Intake Disorder (ARFID) often lack access to specialty dietitians, and scalable nutritional guidance/food chaining tools are currently not available. The investigators will evaluate a web-based, clinician-supervised, generative-AI assistant that produces individualized food-chaining plans. Develop an AI assistant that generates ≥15 allergy-safe, … |
PAUL CROWLEY; | 2025-06-06 |
| 110 | Exploring Parameters of Driving Simulation in Relation to Drug Holidays in ADHD Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Attention deficit hyperactivity disorder (ADHD) or syndrome (ADHS) is a symptomatically defined condition that – if untreated – is linked to a significantly increased risk of traffic accidents. In a recent umbrella review, where data from reviews and meta-analyses on 21.142.129 adults was assessed, a pooled prevalence of 3.1% of ADHD in adults was estimated. Considering that globally around 1.35 million people lose their lives and more than 50 million are suffering from injuries or disabilities due to road accidents, … |
STEFAN LAKÄMPER; | 2025-06-05 |
| 111 | Evaluation of Screen Time and Digital Media on ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. Assess how different types of digital media influence inattention, impulsivity, and hyperactivity in children with ADHD. 2. Analyze the role of screen time duration, content type, parental supervision, and socioeconomic status in ADHD symptom severity. |
JANICE GAMIL SADEK ZAKKA; | 2025-04-18 |
| 112 | Couple-Based Crisis Response Planning for Veterans PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Suicide is a leading cause of death in Veterans. Suicide rates among Veterans have increased approximately 36% from 2001 to 2020. Veterans are at increased risk for suicide compared to non-Veterans, with the rate of suicide death being 57.3% higher for Veterans than non-Veterans. The present study will pilot test a virtual couple-based crisis response plan (CRP-C) for Veterans in order to reduce crisis symptoms and decrease suicide risk. |
BRIAN BAUER; | 2025-06-10 |
| 113 | Advancing Identification of Circadian Delay in ADHD Youth: Associations With Clinical Heterogeneity and Cognition PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to better understand sleep and circadian functioning in children with ADHD using home-based measures, parent report, and a lab based melatonin assessment. Investigators will also examine how sleep relates to psychiatric health and cognition among children with ADHD. The investigator for this study is Dr. Jessica Lunsford-Avery from the Department of Psychiatry. |
JESSICA LUNSFORD-AVERY; | 2025-10-09 |
| 114 | Randomized, Placebo-controlled Clinical Trial to Investigate The Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression (DEXAD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The indication of attention-deficit/hyperactivity disorder (ADHD) to be examined often occurs with other psychiatric disorders, and the majority of adults with ADHD have at least one psychiatric comorbidity in their lives. Depression is one of the most common comorbidities in patients with ADHD. The prevalence of comorbid depression in adults with ADHD is estimated to be as high as 50%. There is evidence that stimulants such as dexamfetamine and methylphenidate lead to an improvement in sustained focused attention, working memory, and a variety of cognitive processes in the prefrontal cortex (PFC). In combination with the pharmacological effects of stimulants, … |
FRANK BEHRENS; | 2026-01-13 |
| 115 | Feasibility and Efficacy of Cognitive-Behavioral Therapy for Patients With ADHD/Behavioral Addiction Comorbidity: A Pilot Randomized Controlled Trial (ADHDDICT) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this pilot study is to assess preliminary data on the feasibility of CBT and its evaluation in a randomised trial in patients with co-occurring ADHD and behavioural addiction: Evaluation and comparison of the 12-week retention rate of patients randomised to CBT compared with patients in the ‘treatment as usual’ control arm. In order to meet the objective, the patient will take part in a standardized assessment, followed by a therapeutic intervention and a new standardized assessment after the intervention. The standardized assessment consists as follows : * firstly, 7 self-questionnaires to be completed by the patient, … |
SERVANE BARRAULT; | 2025-06-25 |
| 116 | COmmunities Aligned to Reduce Concussion and Head Impact Exposure (COACH) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Head impacts in collision sports such as football are a public health concern, as repetitive head impacts, even if a concussion is not suspected, have negative effects on brain health. This study has partnered with a community stakeholder group to create a safety program for youth football named COmmunities Aligned to reduce Concussion and Head impact exposure (COACH), … |
JILLIAN URBAN; | 2025-09-10 |
| 117 | Prediction of Attention Deficit Hyperactivity Disorder (ADHD) in Middle School Children Using Machine Learning With Pedobarographic Data PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the potential of postural control and plantar pressure data in predicting Attention Deficit Hyperactivity Disorder (ADHD) in middle school students using machine learning methods. A total of 100 students will participate, including those identified with symptoms of ADHD and healthy controls. Participants will undergo non-invasive biomechanical assessments, including pedobarographic foot pressure measurement and mobile posture analysis. Behavioral data will be collected using DSM-IV-based rating scales developed by Atilla Turgay, completed separately by parents, teachers, and caregivers. All data will be used to develop predictive models using algorithms such as random forest, … |
GUZIN KAYA AYTUTULDU; | 2025-09-18 |
| 118 | Home-Based Executive Function Training Intervention For Attention-Deficit/ Hyperactivity Disorder-prone Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the effectiveness of a home-based executive function training Intervention on children’s ADHD symptoms, executive function and parents’ parenting stress. |
WUHAN MENTAL HEALTH CENTRE | 2025-04-30 |
| 119 | Trigeminal Nerve Stimulation for Children With Prenatal Alcohol Exposure PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label trial of trigeminal nerve stimulation (TNS) for children aged 8-12 years with attention deficit hyperactivity disorder (ADHD) putatively due to prenatal alcohol exposure (PAE). TNS has been successful in treating pediatric ADHD generally and it is US Food and Drug Administration (FDA)-cleared for this condition. But this will be the first time it is tried for ADHD specifically associated with PAE. In TNS, … |
JOSEPH O’NEILL; | 2025-07-01 |
| 120 | Step-by-Step: Evaluation of A Stepped Care Model for Anger, Defiant, or Aggressive Behavior in Children and Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim of this project is to examine the effectiveness of a stepped care model of interventions for children’s defiant or aggressive behavior problems. The stepped model consists of a brief internet-based parenting support program (Step 1). For those with continued need of additional interventions, Step 2 includes access to one of following interventions: b) a Cognitive Behavior Therapy (CBT) -Virtual Reality (VR)-assisted parenting support program, b) a Cognitive Behavior Therapy -Virtual Reality-assisted child intervention, or c) standard interventions/support at the family’s unit/clinic and continued access to the study’s internet-based parenting support program, … |
PIA ENEBRINK; | 2026-03-06 |
| 121 | A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-controlled, Trial to Evaluate The Efficacy and Safety of EB-1020 Once Daily QD XR Capsules Administered Orally at Low or High Dose in Adults With Attention-deficit/Hyperactivity Disorder PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the efficacy and examine the safety of two doses of EB-1020 QD XR capsule administered once daily orally in adult ADHD patients. |
OTSUKA PHARMACEUTICAL | 2025-04-16 |
| 122 | Adults With Attention Deficit Hyperactivity Disorder / Substance Use Disorder Comorbidity in Integrated Treatment: Effectiveness and Feasibility PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Attention Deficit Hyperactivity Disorder (ADHD) and Substance Use Disorders (SUDs) is a highly common comorbid condition associated with serious medical and psychosocial consequences. However, and despite the international consensus recommending integrated treatment for this comorbidity, few studies tested the efficacy of specific psychotherapeutic treatment for this comorbidity. The aim of this study is to test the efficacy of a specific group Cognitive and Behavioral Therapy (CBT) for the treatment of adults with this comorbidity. This is a longitudinal, randomized controlled intervention study utilizing a crossover design between the intervention and treatment-as-usual (TAU) waitlist condition, … |
NORMAN THERRIBOUT; | 2025-06-26 |
| 123 | (Neuro)Cognitive Remediation for Adults with Operational Stress Injuries PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: (Neuro)Cognitive remediation (CR) is an intervention for people experiencing cognitive impairments that interfere with their daily functioning. Cognition refers to a person’s ability to perceive, process, manipulate and respond to information. Attention, memory, abstract reasoning, and processing speed are all examples of cognitive skills. By focusing on improving these underlying skills, the overall aim of cognitive remediation is to improve the participant’s daily satisfaction and success. CR can be achieved through teaching compensatory strategies, … |
ABRAHAM RUDNICK; | 2025-02-07 |
| 124 | Effect of Black Cumin Seed Oil on Cortisol, Stress and Quality of Life in Healthy Moderately-Stressed Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study will be to collect data to support the role of black cumin seed oil, also known as black seed oil (BSO), in moderating the stress response, including objective markers of stress (cortisol/DHEA) as well as subjective measures (mood/stress/sleep/beauty). The primary outcomes will be salivary cortisol, subjective stress, and psychological vigor. Subjects will be recruited from among the clients of the Certified Mental Wellness Coaches (CMWCs) that have passed the digital badge course via Marietta College (https://www.credly.com/org/marietta-college/badge/certified-mental-wellness-coach-cmwc-online). If volunteers meet the inclusion/exclusion criteria, they will review/sign the Informed Consent Form (ICF – … |
SHAWN TALBOTT; | 2025-04-30 |
| 125 | Investigating The Prognostic Accuracy of Different Biomarkers for Detection of Developmental Language Disorder in Children With Neonatal Encephalopathy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this ambispective cohort study is to reveal the early indicators of delayed language development in children born with hypoxic-ischemic encephalopathy (HIE). We will examine the prognostic accuracy of different biomarkers, with a special focus on the ADC values of the corpus callosum. The main questions it aims to answer are: 1. To what extent does hypoxic-ischemic encephalopathy (HIE) in infancy affect intellectual development (IQ), receptive and expressive language abilities at different levels of the language system, … |
SEMMELWEIS UNIVERSITY | 2025-08-22 |
| 126 | A Phase 2, Double Blind, Randomized, Placebo-controlled Crossover Trial to Evaluate The Efficacy and Safety of Atomoxetine in Adults with Melanocortin Obesity Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase 2 randomized placebo-controlled crossover trial to determine the safety and efficacy of atomoxetine for treating obesity caused by loss-of-function variants in the melanocortin-4 receptor (MC4R), the most common cause of genetic obesity disorders. Atomoxetine was selected for this pilot trial because it has been shown to increase brain-derived neurotrophic factor (BDNF) within the central nervous system and in peripheral circulation. Targeting BDNF is a specific strategy for treating MC4R abnormalities because BDNF functions as a downstream mediator of MC4R signaling. |
JOAN HAN; | 2025-03-27 |
| 127 | Transcranial Electrical Stimulation Modalities for The Treatment of Clinical Symptoms and Cognitive Deficits in Attention-deficit Hyperactivity Disorder Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project investigates the efficacy of transcranial electrical stimulation (tES) modalities, specifically transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), for treating Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adolescents. |
MOHAMMAD ALI SALEHINEJAD; | 2025-05-15 |
| 128 | A Phase 3b, Randomized, Double-blind, 8-week, Placebo-controlled Trial to Evaluate The Efficacy and Safety of Centanafadine Once Daily Extended-release Capsules for The Treatment of Adults With Attention-deficit/Hyperactivity Disorder and Comorbid Anxiety PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Primary: To evaluate the efficacy of CTN in adults ages with ADHD and comorbid anxiety (AISRS) Key Secondary: To assess the efficacy of CTN in adults ages with ADHD and comorbid anxiety |
OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION | 2025-09-26 |
| 129 | The Effects Of Occupation-Based Self-Regulation Program On Sensory Processing, Executive Functions and Occupational Performance In Preschool Children With Screen Addiction PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this interventional study was to measure the effectiveness of a self-regulation program for screen addiction in preschool children aged 4-5 years. The main questions it aimed to answer were: Does a self-regulation intervention program reduce screen addiction in preschool children? Does a self-regulation intervention program improve self-regulation skills in preschool children? Does a self-regulation intervention program improve sensory processing skills in preschool children? Does a self-regulation intervention program improve reading performance in preschool children? |
YASIN TEKECI; | 2025-06-06 |
| 130 | Investigation of Motor Development, Sleep Characteristics and Sensory Processing Skills of Infants With A History of Colic PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to evaluate the motor development, sleep characteristics and sensory processing skills of infants with a history of colic and to compare them with their peers without a history of colic. |
RABIA ZORLULAR; | 2025-06-26 |
| 131 | Establishment of A Longitudinal Cohort for Newborns With Low Apgar Scores at Birth PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to identify high-risk factors associated with low Apgar scores, implement proactive interventions to reduce their occurrence, and analyze neonatal resuscitation procedures and systemic treatment during hospitalization. This aims to provide evidence-based references for improving the resuscitation and medical management of newborns with low Apgar scores, thereby enhancing clinical care capabilities. Additionally, continuous follow-up management and timely intervention guidance will be provided to these infants to optimize their long-term prognosis. |
PEKING UNIVERSITY THIRD HOSPITAL | 2025-05-07 |
| 132 | Evaluating The Efficacy of Atomoxetine in Reducing Primary Nocturnal Enuresis in Children With ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. Primary Aim: To evaluate the efficacy of atomoxetine in reducing the frequency of primary nocturnal enuresis episodes in children with ADHD. 2. Secondary Aim: To determine if improvements in attention symptoms correlate with reductions in nocturnal enuresis episodes. |
OSAMA IBRAHIM YOUNES; | 2025-02-27 |
| 133 | A Phase 2 Randomized Double-Blind, Parallel, Adaptive-Design, Clinical Trial to Evaluate The Safety and Efficacy of NRCT-101SR With NRCT-202XR Compared to NRCT-202XR Alone in Subjects With Attention-Deficit/Hyperactivity Disorder Related Papers Related Patents Related Grants Related Experts Highlight: A combination therapy of NRCT-101 with NRCT-202 is being developed for patients with ADHD. |
NEUROCENTRIA | 2026-01-15 |
| 134 | Digital Health Intervention for Children With ADHD: Improving Mental Health Intervention, Patient Experiences, and Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To conduct an RCT to evaluate the efficacy of the system, we will recruit 60 children (ages 8-12) with ADHD who will be randomized to either immediate (n=30) or delayed (n=30) treatment (i.e., a wait-list control group). Among those randomized to immediate treatment, half will be assigned to DHI (delivered via a smartwatch and smartphone application) and half will be assigned to an active control treatment as usual (TAU) group who will receive the smartwatch with no assigned activities, applications, or interventions on the devices. The intervention period will last 16 weeks; … |
SABRINA SCHUCK; | 2026-01-28 |
| 135 | ADHD Remote Technology and ADHD Transition: Predicting and Preventing Negative Outcomes PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition affecting 5.9% of young people. Late adolescence can be a particularly challenging period for young people with ADHD, with major life transitions, new demands and increased expectations. This vulnerable phase also coincides with the transition from child and adolescent mental health care to adult ADHD services, where new UK data show that most young people with ADHD do not successfully transfer to adult services. Therefore, … |
JONNA KUNTSI; | 2025-11-26 |
| 136 | Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the occurrence of involuntary movements (motor tics) and vocalizations (phonic tics). The onset of TS is usually in childhood, and the prevalence of TS is estimated between 0.3 and 0.9% before the age of 18, decreasing progressively after that age. Most patients also suffer from associated psychiatric comorbidities (ADHD, OCD, mood disorders). Although the cause of TS remains unknown, the preferred hypothesis is the interaction of predisposing genetic factors and precipitating environmental factors (perinatal accidents, infectious diseases). From a pathophysiological point of view, it is widely demonstrated by structural, … |
EDOUARD COURTIN; | 2025-04-03 |
| 137 | The Effect of A Brief Educational Intervention for Adults With ADHD: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This RCT-study proposes the evaluation of an intensive educational intervention tailored for adults with Attention Deficit Hyperactivity Disorder (ADHD) in community mental health centers (CMHCs). Given the prevalent challenges of prolonged waiting lists and low patient engagement in CMHCs, the research seeks to assess the efficacy of this intervention in enhancing patient engagement, self-efficacy, satisfaction with the information and overall health outcomes. The intervention, developed collaboratively with user representatives, combines a brief group-based educational sessions with standard clinical care. The primary hypotheses posit that this approach will lead to increased patient satisfaction with the treatment, patient self-efficacy, … |
MARIELA LORETO LARA-CABRERA; | 2025-07-08 |
| 138 | Pai.ACT: An Artificial Intelligence-Driven Chatbot-Assisted ACT Mobile Platform With Mental Health Triage – A Randomized Controlled Trial and Regional Service Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Parents of children with special needs in Hong Kong often face limited psychological support, which can negatively impact the child rehabilitation process and the well-being of parent-child relationships. To address this gap, we have developed Pai.ACT, the first deep learning-based mental health advisory system for parents. Pai.ACT features an AI chatbot that integrates the counselling principles of Acceptance and Commitment Therapy (ACT) through natural language processing, providing parents with a human-like voice-to-text experience. Using data from chatbot interactions, … |
YUEN YU CHONG; | 2025-02-12 |
| 139 | Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models: Testing Speech-Based Machine Learning Algorithms for Clinical Assessment and Risk Stratification in Mental Health Presentations PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates whether AI-driven analysis of speech can accurately predict clinical diagnoses and assess risk for various mental or behavioral health conditions, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, bipolar disorder, generalized anxiety disorder, major depressive disorder, obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and schizophrenia. We aim to develop tools that can support clinicians in making more accurate and efficient diagnoses. |
JULIANNA OLAH; | 2025-09-03 |
| 140 | A Pilot Study of A Remote Attention-Deficit/Hyperactivity Disorder Monitoring Program (RAMP) for Children in Rural Areas PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: RAMP is a pilot study examining the use of an Attention-Deficit/Hyperactivity Disorder (ADHD) Monitoring Program during the early stages of treating ADHD in children living in rural settings. This trial will enroll 36 caregiver/infant dyads across 2 sites and will evaluate feasibility endpoints rather than clinical outcomes. Enrolled participants will be randomized 1:1 to the intervention group (RAMP reports) or control group (digital education handouts). The study duration is 10 months, including start-up, enrollment and intervention, and data analysis and manuscript submission. |
HANNAH FORD; | 2025-06-24 |
| 141 | Intervention with Weighted Blankets for Children with ADHD and Sleep Problems: Implementation and Effectiveness PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim is to study a sleep intervention with weighted blankets in children with ADHD and sleep problems regarding 1) short- and long-term effects on sleep and health-related outcomes in comparison with standard treatment (melatonin), 2) barriers and facilitators to implementation in routine clinical practice, and 3) health-economic outcomes. |
INGRID LARSSON; | 2025-02-05 |
| 142 | Project EMBRACE: Embracing Morning BReakfast and Activity for Classroom Engagement PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This experiment will test the effects of healthy breakfast and morning exercise on children’s focus and classroom behavior. Food and exercise each influence child focus, but little is known about their effects on classroom behavior and less about their combined effects. For one week (Monday-Friday), 10 children will be randomly assigned to receive healthy breakfast and morning exercise, 10 assigned to only healthy breakfast, 10 to only exercise, and 10 to neither. After exercise and breakfast, study staff will assess how focused children are during class-time, ask them to complete puzzle-like tasks, … |
EDUARDO BUSTAMANTE; | 2025-05-07 |
| 143 | Exploring Eye Vergence Markers in Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators study aims to evaluate the utility of eye vergence, an eye-tracking measure, as an indicator of visuo-spatial attention in children aged 4-17 years and adults, using computer-based eye-tracking tasks. Eye vergence, a binocular movement crucial for depth perception, has recently been linked to attentional control and neurodevelopmental conditions (NDCs) like ADHD and ASD. The investigators will work with children and adults from the CAN and Beckenham clinical centres to explore the relationship between eye vergence and diagnostic categories, potentially identifying subgroups with specific or overlapping attentional differences. This research may aid in the early detection of attention deficits, … |
ELIZABETH KILBEY; | 2026-02-03 |
| 144 | Evaluation of The Effects of Different Dietary Practices on Quality of Life and Eating Behavior in Children with Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the effects of gluten-free casein-free diet and feingold diet on gastrointestinal system (GI) symptoms , eating behavior and quality of life in children with autism spectrum disorder. Research questions are below: Is there a difference in the effects of a gluten-free-casein-free diet and the Feingold Diet on GI symptoms? Is there a difference in the effects of a gluten-free-casein-free diet and the Feingold Diet on eating behavior? Is there a difference in the effects of a gluten-free-casein-free diet and the Feingold Diet on quality of life? |
SIMGE GÜREL; | 2025-02-28 |
| 145 | Assessment of Depression, Anxiety and ADHD Among Children and Adolescents with Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Congenital heart disease (CHD) is the most common birth defect, affecting ∼1% of all live births.The spectrum of CHD is wide, ranging from simple (not requiring immediate or possibly any surgical intervention) to severe or complex (typically defined as CHD requiring surgical intervention within the first month to year of life). |
SAMIA ASHRAF ABBDELGAWAD; | 2025-02-20 |
| 146 | Promoting Motivation and Linguage in Developmental Language Disorder Through Interaction With The Humanoid Social Robot PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Developmental Language Disorder (DLD) is a communication disorder that interferes with learning, understanding, and using language. This pilot study investigates the use of the humanoid robot NAO as part of a rehabilitative program designed for children with DLD. NAO, with its predictable and engaging interaction style, is hypothesized to enhance communicative initiative, expressive communication, and social interaction in this population. The study employs a randomized controlled trial design, assigning participants to either a NAO-assisted intervention group or a control group receiving standard therapy. Outcomes will be assessed using standardized measures of communication, motivation, … |
CUCINOTTA FRANCESCA; | 2026-02-23 |
| 147 | Enhancing Preschool Children’s Attention and Behaviour: Parent-Focused Program PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the feasibility and efficacy of the Building Regulation in Dual Generations (BRIDGE) program for caregivers with significant mental health concerns and preschool and young children (3-7 years old) with elevated attention and/or behavior problems. The BRIDGE program focuses on supporting parental psychological distress and improving young children’s self-regulation (SR), thereby reducing their attention and behavior problems (Bridgett et al., 2015; Brikell et al., 2015; Landstedt and Almquist, … |
TASMIA HAI; | 2025-07-24 |
| 148 | An Open-Label Treatment With Randomization Observation, Investigator-Initiated Study, on The Duration and Efficacy of Jornay PM (Methylphenidate Hydrochloride Extended-Release Capsules) on Adult ADHD Symptoms and Executive Function and Emotional Regulation Throughout The Day Into Early Evening PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to extend the efficacy evidence of sustained release methylphenidate compound (JornayPM) in adults with Attention-deficit/hyperactivity disorder (ADHD). JornayPM has recently been approved for treatment of patients 6 years and older with ADHD; the release mechanism is unique among ADHD products in that it is taken in the evening, with effects in the morning upon awakening and then throughout the subsequent day. Of note, to date, there is no clinical data as to the tolerability or clinical effects or dosing in adults with ADHD; … |
LENARD ADLER; | 2025-06-25 |
| 149 | A Therapist-guided Online-delivered Group Counseling Program for Pregnant Women and New Mothers With ADHD: A Feasibility Study of AMOR; ADHD, Mothers Online Resources PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim of this study is to investigate the feasibility of the program AMOR for pregnant women and new mothers with Attention Deficit Hyperactivity Disorder (ADHD), by examining adherence, credibility, treatment satisfaction, and negative effects. The secondary objective is to obtain preliminary information about the short-term clinical outcomes of the program on self-report scales assessing symptoms of ADHD, stress, anxiety, depression, difficulties in emotion regulation, and quality of life. The main questions this study aims to answer: 1. To what extent will pregnant women and new mothers with ADHD adhere to, find useful, be satisfied with, … |
UNIVERSITY OF SOUTHERN DENMARK | 2026-01-08 |
| 150 | Supporting Expectant Mothers With ADHD Through The Transition to Parenthood PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study will develop and test a behavioral program for pregnant individuals with Attention-Deficit/Hyperactivity Disorder (ADHD). This behavioral program will include skills for managing ADHD and related symptoms during pregnancy and after delivery and will be taught by a behavioral therapist in OB care settings. |
HEATHER JOSEPH; | 2026-01-08 |
| 151 | An Investigational Study Examining The Cross-Validation of QbMobile in ADHD and Normative Populations PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate QbMobile ability to collect and provide accurate and objective data which can be used to facilitate assessment and treatment procedures for ADHD in a clinical setting as well as remotely. |
QBTECH AB | 2025-12-31 |
| 152 | An Investigational Study Examining The Efficacy of QbMobile in Treatment Monitoring in Individuals With ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The current study will investigate if QbMobile can be used to improve the accuracy and objective identification of reduced ADHD symptoms in tests scores once treatment has been initiated. |
QBTECH AB | 2025-12-31 |
| 153 | The Effects of Methylphenidate on Symptomatology in Individuals With Borderline Personality Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the effects of methylphenidate on symptomatology in individuals with borderline personality disorder. Specifically, it will evaluate whether Concerta is effective in reducing impulsivity, mood instability, and inattention among patients with BPD. Additionally, the study will assess Concerta’s safety profile in this population to determine its potential as a supportive pharmacological option in BPD management. |
OSAMA IBRAHIM YOUNES; | 2025-03-25 |
| 154 | Improving Emotion Dysregulation and Interpersonal Conflict Among Families of Adolescents With ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study consists of a randomized controlled trial assessing the acceptability, feasibility, and efficacy of the RELAX (Regulating Emotions Like An eXpert) Intervention. Following randomization, 30 families will receive the RELAX intervention and 30 families will receive psychoeducational materials as part of a control condition. Additionally, 10 families from the RELAX condition will participate in a pilot study and focus groups to give feedback on developed smartphone apps to support skill use during and following completion of RELAX. |
ROSANNA BREAUX; | 2026-03-30 |
| 155 | A Multi-Center, Randomized, Double-Blind, Parallel Group, Placebo-controlled Phase II Trial of TTYP01 Tablets in Adolescents and Children With Autism Spectrum Disorders PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multi-center, randomized, double-blind, multiple dose levels, parallal group, placebo-controlled study, to evaluate the safety, PK profiles and preliminary efficacy of TTYP01 tablets in adolescents and children with ASD. |
SHANGHAI AUZONE BIOLOGICAL TECHNOLOGY | 2025-05-14 |
| 156 | A Stage 1 Pilot Test for Feasibility and Efficacy of A Multi-Level Intervention to Increase Physical Activity in Adults With Intellectual Disability: Physical Activity and Community EmPOWERment (PACE) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer’s Disease (AD)/age-related dementias (ARD). Participants: Participants include 120 adults with ID, their caregivers, and their coaches (up to 360 individual participants, grouped as triads), recruited through the University of North Carolina at Chapel Hill and the University of Arkansas. Participants also include 16 exercise professionals. Procedures (methods): Each cohort will include 20 triads who are randomly assigned to the PACE program or the waitlist control group. |
BRIANNE R TOMASZEWSKI; | 2026-02-23 |
| 157 | The Efficacy of Dual-target ITBS in Youth With Attention-Deficit/Hyperactivity Disorder (ADHD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will employ accelerated intermittent theta burst stimulation (aiTBS) targeting two transcranial magnetic stimulation (TMS) sites: the right inferior frontal gyrus and left inferior parietal lobule. |
SHANGHAI MENTAL HEALTH CENTER | 2025-07-24 |
| 158 | VItamin D in PregnanCy for PrevenTion Of EaRlY Childhood Asthma (VICTORY) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma/persistent wheeze during the first three years of life as we hypothesize that supplementation in higher doses than recommended could reduce the risk of disease development. |
KLAUS BØNNELYKKE; | 2025-09-30 |
| 159 | An Intervention Study on Transcranial Photobiomodulation for Children With Attention-Deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to intervene in children and adolescents with ADHD using transcranial photobiomodulation, comparing its effects on executive function at the levels of electroencephalography (EEG), eye tracking, and cognitive behavior. The goal is to identify the most effective clinical treatment strategy for ADHD patients. |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2025-07-22 |
| 160 | CBG and Attention: A Double-Blind, Randomized, Placebo-Controlled Trial Examining The Effects of Cannabigerol on Indicators of Attention-Deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the effects of Cannabigerol (CBG) on indicators of Attention-Deficit/Hyperactivity Disorder (ADHD) in a sample of participants indicating/reporting symptoms associated with ADHD. The main question it aims to answer is: Does CBG reduce ADHD-related indicators relative to placebo? Participants will administer an acute dose of placebo or 80mg CBG and complete outcome measures at 45 minutes and 75 minutes. Daily surveys to monitor safety will be administered for one week following administration. |
ELLEN LEEN-FELDNER; | 2025-04-02 |
| 161 | External Trigeminal Nerve Stimulation Versus Sham Stimulation for Attention Deficit Hyperactivity Disorder in Children and Adolescents Aged 7-17 Years: Study Protocol for A Pilot and Feasibility Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators will assess the use of the Monarch eTNS device as a non-pharmacological treatment for patients aged 7 to 17 years with ADHD. The investigators will compare the eTNS device to a sham device. Participants will use the device for four weeks during night time. During the trial, participants will receive different questionaires to assess symptoms and will also keep a logbook to record their experience with the device. At the end of trial, the investigators will assess what the families thought of the device, … |
OLE JAKOB STOREBØ; | 2026-03-09 |
| 162 | THE EFFECT OF HEALTH EDUCATION ON DIGITAL GAME ADDICTION AND HEALTH PROMOTION BEHAVIOR IN ADOLESCENTS PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Nowadays, among adolescents who are frequently exposed to digital technologies, problematic behaviors resulting from misuse such as problematic internet use, video game addiction, and online gaming disorder are commonly observed (Young, 2017). In the literature, the prevalence of digital game addiction among adolescents has been reported to range between 0.7% and 15.6% (Arifin et al., 2022; Karadağ \& Noyan, 2023; Miezaha et al., 2020; Yudes et al., 2021). Promoting health-enhancing behaviors plays a key role in combating digital game addiction in adolescent health (Daysal \& Yılmazel, … |
SERPIL ÖZDEMIR; | 2025-06-03 |
| 163 | Effectiveness of A Positive Psychology and Mindfulness Based App for Parents of Children with A Neurodevelopmental Disorder (NDD): Study Protocol of A Pragmatic Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: An app based on positive psychology and mindfulness to support the mental well-being of parents of children with a Neurodevelopmental Disorder (NDD) was developed and will be evaluated on effectiveness. |
KIM TONIS; | 2025-02-21 |
| 164 | Comparative Effectiveness of FNIRS-Based Neurofeedback Training in Children With ADHD: The Impact of Virtual Reality Integration PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to explore whether the treatment using fNIRS-based neurofeedback training for children with attention-deficit/hyperactivity disorder (ADHD) is useful. Furthermore, the study hopes to evaluate whether the use of virtual reality (VR) technology will have an impact on the treatment’s effectiveness. The program includes the following components: Participants will be randomly assigned to one of three intervention groups: the neurofeedback with virtual reality (VR) group, the 2D neurofeedback group (with no VR technology applied), … |
KATHY SHUM; | 2025-12-31 |
| 165 | Effect of Vojta Therapy on Motor Control in Children With Attention Deficit Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: ADHD is generally associated with significant comorbidities including motor disorders in up to 96% of cases. Within these, disturbances of balance and motor coordination that interfere with school learning and daily activities are present in 47% of school children with ADHD. Therefore, the aim of this research is to determine whether Vojta therapy is beneficial for the improvement of balance, postural control, hand-eye coordination and manipulative motor skills in children with ADHD, hyperactive and/or combined, aged 6-12 years. |
JOSUE FERNANDEZ CARNERO; | 2025-03-07 |
| 166 | I-InTERACT Preterm Parenting Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Many children born very preterm experience behavior problems, and existing resources for parenting these children are lacking. A pilot trial established the effectiveness of a preterm parenting intervention, I-Interact Preterm (I2P). This study proposes a three-arm randomized controlled trial (RCT) comparing the established seven-session I2P program, a microlearning delivery mode (I2P-Micro), and an internet resource comparison group (IRC). Outcomes will be assessed at pretreatment, post-treatment (12 weeks later), and at an extended follow-up six months post-randomization. These outcomes include parenting behaviors, child behavior problems, … |
SHARI WADE; | 2026-02-09 |
| 167 | Non-randomized Controlled Pilot Study of A Health Promotion Program for Mothers of Children in The Ultra-orthodox Community: Examining Feasibility PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to evaluate the feasibility and effectiveness of a health promotion intervention for Ultra-Orthodox Jewish mothers of children with ADHD. This study will examine the impact of a culturally tailored group-based intervention aimed at reducing stress, enhancing health, … |
ADINA MAEIR; | 2025-05-01 |
| 168 | Using Smartphone Sensors to Assess Symptom Relief in Patients With Social Anxiety Disorder Undergoing Gaze Contingent Music Reward Therapy (GC-MRT) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to examine if a digital behavior-based framework, utilizing the BHQ app, can effectively monitor social anxiety symptoms and evaluate the symptom-reducing impact of attentional training for adults (18-65) with social anxiety disorder (SAD), … |
YAIR BAR-HAIM; | 2025-09-08 |
| 169 | Feasibility Trial of A Guided Internet-delivered Intervention for Adolescents With ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main aim of this feasibility trial is to investigate the feasibility and preliminary clinical outcomes of a guided digital intervention for adolescents with ADHD. Adolescents with ADHD will be enrolled in a 6-week digital intervention including weekly therapist contact. The adolescents and their parents will be asked to complete self-report questionnaires at pre-, during, post- and 3- and 6-months follow-up. |
TINE NORDGREEN; | 2025-12-19 |
| 170 | Evaluation of Sustained Endogenous Attention Deficits in Attention Deficit Hyperactivity Disorder: Validation of A Computerized Neuropsychological Test. PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Subjects with ADHD may exhibit deficits in sustained internal attention. The Sustained-Paced Finger Tapping test was recently developed and experimentally used in international literature to assess sustained internal attention in typically developing children. This clinical study has several objectives: 1) to assess the presence of internal sustained attention deficits in children with ADHD through the Sustained-Paced Finger Tapping; 2) to evaluate the discriminant and ecological validity of the Sustained-Paced Finger Tapping. |
IRCCS EUGENIO MEDEA | 2025-03-28 |
| 171 | Testing The Potential of High-dose Vitamin B6 Supplements for Sensory Reactivity in Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to explore the effect of Vitamin B6 supplementation on anxiety sensory hyperreactivity in autistic adults. Researchers will compare a placebo group to high-dose Vitamin-B6 to see if vitamin B6 reduce anxiety and sensory reactivity differences in autism. |
DAVID FIELD; | 2026-03-11 |
| 172 | Examining Symptom-Specific Effects of Omega-3 Fatty Acids in Children with ADHD / ASD Symptoms and Sleep Problems: A Network Approach PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Our study aims to determine whether omega-3 fatty acid supplementation can improve sleep, mood, and behavior in children with sleep problems and symptoms of Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), or both. By using a transdiagnostic approach-focusing on specific symptoms rather than diagnostic labels-we aim to identify which children may benefit most from omega-3 supplementation, thereby enhancing inclusivity. Many previous studies have excluded children with both ASD and ADHD, or those without a formal diagnosis. |
SWANSEA UNIVERSITY | 2025-12-01 |
| 173 | Daily Routines and Executive Functioning in Youth with ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn adjusting daily or nightly routines improves executive functioning in youth with ADHD. It will also learn about the acceptability of the intervention. The main questions it aims to answer are: 1. Does the intervention improve sleep for youth with ADHD? 2. Does the intervention improve areas of executive functioning for youth with ADHD? 3. Is this an acceptable intervention for youth with ADHD? Researchers will compare the two intervention conditions to see if their are impacts in executive functioning and sleep. Participants will: Complete cognitive testing, executive function tasks, questionnaires, … |
CORI MANNING; | 2025-06-01 |
| 174 | Neuroimage-guided Dual-target Continuous Theta Burst Stimulation for Generalized Anxiety Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this clinical trial was to determine whether image-guided dual-target cTBS is effective for anxiety disorders. The main questions it aims to answer are: 1. Does dual-target cTBS improve patients’ anxiety symptoms? 2. Does dual-target cTBS improve patients’ somatization symptoms? 3. Researchers will compare cTBS real and sham stimulation to determine whether cTBS is effective in treating anxiety disorders. Participants will: 1. Received either cTBS treatment or sham stimulation for 7 consecutive days 2. Psychological assessment and MRI scan were performed before treatment, within 2 days, … |
WANG KAI; | 2025-08-22 |
| 175 | Personalizing Behavioral Parent Training: Improving Reach and Outcomes for Families of Children With ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of the study is to develop and pilot a personalized behavioral parent training intervention for caregivers of children with attention deficit hyperactivity disorder. The behavioral intervention will teach positive parenting through videos and quizzes that caregivers can access through a smartphone application. The program also gives parents and caregivers in-the-moment feedback their use of parenting strategies. The main questions to answer are: Is parenting feedback provided by a smartphone application acceptable to caregivers? Is the phone application usable and acceptable to parents and caregivers of children with attention deficit hyperactivity disorder? In the pilot trial, … |
FLORIDA INTERNATIONAL UNIVERSITY | 2025-08-29 |
| 176 | The Effectiveness of Cognitive-Functional Remote Group Intervention (Cog-Fun RG) for Adults with Attention Deficit Hyperactivity Disorder (ADHD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to examine the effectiveness of Cognitive-Functional Remote Group intervention (Cog-Fun RG). The main questions of this study are 1. will participants demonstrate improvements in their executive functioning and quality of life after receiving the intervention, compared to waitlist controls. In addition, … |
ADINA MAEIR; | 2026-02-01 |
| 177 | Settling Down for Sleep: The Impact of Sensory and Arousal Systems on Sleep in ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is test the hypothesis that sleep problems for children with ADHD are linked to sensory over-responsivity, a type of sensory processing difference that causes a person to interpret daily sensory input as stressful. This study examines the impact of sensory over-responsivity on bedtime arousal levels in 30 children with ADHD (ages 6-13). We will also test a bedtime intervention targeting sensory over-responsivity at bedtime and examine how it impacts bedtime arousal levels and sleep difficulties. |
AMY HARTMAN; | 2025-08-12 |
| 178 | Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the general population. Current clinical care for individuals with tic disorders is limited: no interventions are proven to prevent or stop the disorder exist, and most treatments focus solely on tics, though other symptoms often affect quality of life more than tics. To develop new treatments and improve care for people with tics, … |
DAVID ISAACS; | 2025-11-24 |
| 179 | Clinical Study on Acupuncture Treatment for Attention Deficit Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the efficacy of acupuncture as a treatment for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 6-12 years. Using a mixed-methods approach, the research will triangulate data from acupoint data mining, treatment outcomes assessment, and patient perspectives to provide a comprehensive analysis of acupuncture’s potential therapeutic benefits for ADHD. This prospective cohort study will recruit children diagnosed with ADHD, assigning them to receive either acupuncture combined with traditional Chinese herbal treatment or herbal treatment alone. Quantitative assessments using the the SNAP-IV, Conners 3-P, BRIEF-2, PedsQL™ 4.0 Generic Core Scales, … |
TANANAN SANGWANIT; | 2025-12-19 |
| 180 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Investigator-initiated Human Study to Evaluate The Efficacy and Safety of Lactococcus Lactis KD10 Powder in Improving Autism Spectrum Symptoms in Pediatric Patients With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This human study aims to evaluate the efficacy and safety of Lactococcus lactis KD10 powder for improving autism spectrum disorder symptoms in patients with autism spectrum disorder. |
MIAE OH; | 2025-08-22 |
| 181 | Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to compare the effectiveness of a novel personalized surgical approach to the standard AT in children with small tonsils (ST). This will be accomplished by randomizing children with ST and OSA to one of these two treatments and comparing outcomes after 6 months. It is the investigators’ central hypothesis that a personalized drug-induced sleep endoscopy (DISE)-directed surgical approach that uses existing procedures to address the specific fixed and dynamic anatomic features causing obstruction (ie, … |
DEREK LAM; | 2025-09-24 |
| 182 | Development of Novel Psychological Assessment Tools and Anxiety Intervention for PKU: Intervention Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: While previous PKU intervention research has largely focused on pharmacological treatment of elevated Phe levels, the adaptation of evidence-based psychosocial therapy holds promise for addressing cognitive and psychological symptoms and significantly improving quality of life. Study goals include: (1) to demonstrate the efficacy and feasibility of a short-term skills-based intervention (Show Me FIRST) for anxiety and depression in adolescents with PKU, … |
SHAWN CHRIST; | 2025-12-23 |
| 183 | Efficacy and Safety of Black Seed Oil As Adjunctive Therapy in Pediatrics With Attention-Deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Attention-Deficit/Hyperactivity Disorder is one of the most prevalent neuropsychiatric disorders affecting children with known persistence into adulthood in about 60% of patients. The mainstay treatment for ADHD is the pharmacological treatment involving stimulants (methylphenidate, amphetamines) and non-stimulants (atomoxetine, guanfacine, clonidine). Although these options have been found to be effective, these agents may not always be promising, as a proportion of patients may not respond or may not be able to tolerate their adverse events. Thus, increasing studies are exploring alternative therapies for ADHD, … |
MANAR HOSNEY; | 2025-10-01 |
| 184 | MultitArget STereotactic Electrophysiological Recording and Stimulation for Tourette Syndrome Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to investigate the neural mechanisms underlying Tourette syndrome (TS) and see if personalized deep brain stimulation (DBS) can help reduce tics in TS patients and improve related issues like anxiety, attention problems, and obsessive-compulsive behaviors. In this study, researchers will use stereoelectroencephalography (SEEG) and electrocorticography (ECoG) to record brain activity in key areas involved in movement and emotion, including the nucleus accumbens (NAc), anterior limb of the internal capsule (ALIC), insular cortex, anterior cingulate cortex (ACC), central medial thalamic nucleus (CM), globus pallidus internus (GPi), … |
JIANGUO ZHANG; | 2025-05-22 |
| 185 | Comparative Effects of Individual and Grouped Sensory Perceptual Motor Training on Gross Motor Skills and Quality of Life in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Autism is the most prevalent disorder as it affects attention, awareness, cognitive development, social development, and emotional aspects too. It is one of the comprehensive developmental disorders in the early stage, which is characterized by weak social learning and communication, limited activities, interests, learning, insufficient imaginative and stereotypical thinking or non-functional thinking of movements and verbalities. A lack of sensory perception leads to a leading autistic child's sensitivity to sensory stimuli or weak sensitivity and the child is not aware of the surrounding environment. |
SARA SATTAR; | 2025-01-10 |
| 186 | A Study on The Mechanisms of Sulforaphane in Improving Autism Spectrum Disorder Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to find out if sulforaphane (SFN) can improve social skills and behavior in people with Autism Spectrum Disorder (ASD). ASD is a developmental disorder that affects how children and teenagers interact with others. The number of people diagnosed with ASD has been rising, … |
JIAN-JUN OU; | 2025-09-04 |
| 187 | Phase 3, Multicenter, 3-Week Fixed-dose, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy, Safety and PK Study of Evening Dosed Methylphenidate Hydrochloride ER Capsules (HLD200) in Children Aged 4-5 Years With ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will evaluate the efficacy, safety and pharmacokinetics of HLD200 (20 mg and 40 mg) in children aged 4 to 5 years with ADHD. |
IRONSHORE PHARMACEUTICALS AND DEVELOPMENT | 2025-11-06 |
| 188 | A Randomized, Double-blind, Placebo-controlled, Parallel Arm Clinical Trial of De-Stress and Focus Capsule in The Management of Stress, Mental Alertness, Fatigue, and Anxiety PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The current study focuses in clinical validation of the efficacy of nutraceutical product in the management of mental focus and cognition. The benefits of these nutraceuticals extend beyond mere cognitive enhancement. Improved mental focus can lead to increased productivity and efficiency in both personal and professional settings. Individuals who struggle with attention deficits or cognitive fog may find that these supplements help them maintain a sharper and more consistent level of mental clarity. This can translate to better performance at work, as well as improved ability to manage daily tasks and responsibilities. |
RAMSHYAM AGARWAL; | 2024-12-28 |
| 189 | ADHD PreSMA Response Inhibition Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: ADHD children have abnormal inhibitory control, meaning they have trouble stopping themselves from doing something they should not do. This ability to control involves an area in the brain called the pre-supplementary motor area (pre-SMA). Scientists have previously shown that the pre-SMA is abnormal in ADHD patients. In this study, we will use Transcranial Magnetic Stimulation (TMS) to stimulate the pre-SMA and determine the effects on measures that are related to inhibitory control. |
STEVE W WU; | 2026-01-27 |
| 190 | Effectiveness of An Educational Program on Primary School Teachers’ Knowledge and Performance Regarding Attention-Deficit/Hyperactivity Disorder (ADHD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This interventional study aims to evaluate the effectiveness of a structured teaching program designed to improve primary school teachers’ knowledge and classroom performance regarding the management of children diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD). The study focuses on teachers who work with students previously diagnosed with ADHD based on official medical reports to ensure diagnostic accuracy and strengthen the validity of the intervention outcomes. The structured teaching program includes evidence-based information about ADHD characteristics, classroom behavior management strategies, … |
DLNIYA ISMAIL RASHID; | 2026-04-03 |
| 191 | A Feasibility and Efficacy Study of NeuroTrainer Cognitive Training in Students With and Without Attention-Related Difficulties PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to evaluate the feasibility and efficacy of NeuroTrainer cognitive training in improving attentional and executive control functions in students with and without attention-related difficulties. |
JEFF NYQUIST; | 2026-02-28 |
| 192 | Extending The Reach of Evidence-based Practices to Support Student’s Attention and Behavior Through Technology PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to integrate digital health (dHealth) technology into the Collaborative Life Skills Program (CLS), an established, school-based behavioral intervention for students with ADHD, to make the program accessible to schools that serve students from low-socioeconomic (SES) backgrounds. Existing evidence-based interventions for students with ADHD are often inaccessible in schools with limited resources to support implementation. By adapting CLS to include a dHealth tool-CLS-D-investigators aim to improve the feasibility of intervention implementation in schools with limited resources and mitigate disparities in access to evidence-based interventions among students with ADHD who are from low-SES backgrounds. |
MIGUEL VILLODAS; | 2026-03-20 |
| 193 | Augmentation Von Online-Psychotherapie Mit TDCS Bei Der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A randomized controlled two-arm study (RCT) will be conducted. It is planned to randomly assign eligible patients who receive a three-month access to the psychotherapeutic program (Attexis) to either an additional verum-tDCS or placebo-tDCS condition. |
BERTHOLD LANGGUTH; | 2026-02-27 |
| 194 | Efficacy of Bifidobacterium Animalis Subsp. Lactis and Lacticaseibacillus Rhamnosus Mixture in Children With ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates WecProB (Bifidobacterium animalis subsp. lactis and Lacticaseibacillus rhamnosus) to evaluate their potential to improve symptoms and safety in children with ADHD. |
WECARE PROBIOTICS | 2025-04-04 |
| 195 | The Effect of An Oligoantigenic Diet on Core Symptomatology of Children With Attention-Deficit /Hyperactivity Disorder (ADHD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Fifty patients who diagnosed as ADHD syndrome according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM 5) Criteria aged from 6 to 16 years old will be assigned randomly into 2 arms: arm 1: the patients will follow food regimen that cover recommended daily allowance (RDA) for macronutrients and micronutrients suitable for their ages without any food restriction, arm 2: the patients will follow food regimen that cover (RDA) for macronutrients and micronutrients suitable for their ages based on Oligoantigenic diet (OAD). Psychiatric assessment will be done before intervention and after 3 months of intervention. |
HAYA ESSAM IBRAHIM; | 2025-12-12 |
| 196 | Iron Status in Children With Attention Deficit Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Evaluation of the status of iron deficiency in children with attention deficit hyperactivity disorder. |
MARIAM SAFWAT FINIAR FANOUS; | 2025-10-01 |
| 197 | Efficacy of An Occupational Intervention for Quality of Work Life in ADHD: A Randomized Controlled Trial Protocol PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: An adaptation of the Minds@Work intervention to improve quality of life at work for adults living with attention deficit disorder with/without hyperactivity (ADHD), following a group format. |
GENEVIÈVE SAUVÉ; | 2025-05-16 |
| 198 | Klinefelter Syndrome – The Effect of Testosterone Treatment in Puberty. A Randomized, Double-blind Placebo-controlled Intervention Study: ‘The TiPY Study’ PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized clinical trial is to study the effect of testosterone replacement therapy during puberty in boys with Klinefelter syndrome (KS, 47,XXY). The main questions to answer are how treatment with testosterone will affect body fat mass, lipid and glucose metabolism, growth and body proportions, bone mineralization as well as effects on neurocognitive development and emotional and social difficulties. Participants will be randomized to two years treatment with testosterone or placebo. |
LISE AKSGLÆDE; | 2025-02-19 |
| 199 | Effects of Low, Moderate, and High Intensity Exercise on Executive Function, Functional Impairment, and Symptom Severity in ADHD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project investigates the effects of a bicycling exercise at three levels of exercise intensity (low, moderate, and high) on attention deficit/hyperactivity disorder (ADHD) in college students. Specifically, the outcomes of interest in this study are self-reported executive functioning, self-reported functional impairment, and ADHD symptom severity. The hypothesis is that exercise will improve executive functioning, while reducing functional impairment and ADHD symptom severity, and that this response will be most pronounced in the high-intensity exercise group. |
KENT STATE UNIVERSITY | 2024-11-25 |
| 200 | Motor Intervention for Children With Developmental Coordination Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study focuses on the effects of physical activity in schools on the cognitive function and physical fitness of children with and without developmental coordination disorder (DCD). Methods: 58 children with DCD participated in an 8-week exercise program. Children’s standing broad jump (SBJ), 50m dash, 50m*8 shuttle run, mental rotation and executive functions were assessed before and after training. A mixed-design analysis of variance (ANOVA) was conducted separately for each performance variable. |
ZHIGUANG JI; | 2025-05-30 |