Clinical Digest: Recent Clinical Trials on Chronic Fatigue Syndrome (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Chronic Fatigue Syndrome. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Chronic Fatigue Syndrome (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | A Randomized Controlled Trial for Cervicothoracic Sympathetic Chain Block Against Sham Injection Evaluation for Post COVID Condition: The CeASE RCT PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Post-COVID Condition (PCC) affects roughly 2.1 million Canadians, carrying an annual economic burden of CAD $7.8-50.6 billion. It presents across multiple organ systems with symptoms including fatigue, brain fog, palpitations, and orthostatic intolerance, at an annual cost of CAD $1,675-$7,340 per case. A key mechanism underlying many treatment-resistant PCC symptoms appears to be dysautonomia abnormal autonomic nervous system function driven by immune-mediated sympathetic overactivity. Persistent inflammation (cytokine storms, T/B-cell dysfunction, microclots) sustains sympathetic hyperactivity, which in turn perpetuates systemic inflammation and sickness behaviors resembling PCC symptoms. Current treatments including beta blockers, ivabradine, fludrocortisone, and rehabilitation are limited by variable responses, … |
ANUJ BHATIA; | 2026-03-12 |
| 2 | Low-dose Naltrexone (LDN) for The Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A remote trial approach is used, with eligibility open to the state of Alabama. |
JARRED YOUNGER; | 2026-02-09 |
| 3 | Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 Onset ME/CFS Versus Pre-Pandemic ME/CFS Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex chronic illness impacting multiple body systems and characterized by activity-limiting fatigue and post exertional symptom exacerbation, affecting over 3.5 million adults in the US and as many as half of those with long COVID. The mechanisms behind the frequently profound cognitive impairments in MECFS are elusive; however, disruption of the integrity of the blood brain barrier (BBB) and immune cell migration into the brain are thought to contribute to neuroinflammation and related neuropsychiatric burden in MECFS. This project combines brain imaging, neuropsychiatric assessments, … |
ALBA AZOLA; | 2026-01-29 |
| 4 | Investigating The Effect of Swimming on Autonomic and Symptomatic Responses in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Individuals with ME/CFS experience profound exercise intolerance and post-exertional malaise. This remote (app-based) pilot study explores whether light, fully self-paced, swimming may be a tolerable form of movement for people with ME/CFS and related conditions, due to the distinct physiological effects of water immersion. The horizontal posture and hydrostatic pressure of water supports venous return and reduces orthostatic stress, … |
ALEXANDRA COATES; | 2026-03-30 |
| 5 | Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Some people report persistent health problems after receiving the COVID-19 vaccine. These symptoms persist well beyond typical short-term vaccine side effects and are not attributable to any other known medical conditions. This condition is known as Post-Acute COVID-19 Vaccination Syndrome (PACVS). Symptoms can persist for months and affect several organ systems, causing issues such as fatigue, heart-related problems, neurological difficulties, and decreases in both physical ability and mental performance. PACVS shows similarities to Post-Acute COVID-19 syndrome (PACS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The biological processes that cause PACVS are still not fully understood. Recent research indicates that endothelial dysfunction, … |
MIRKO SCHMIDT; | 2026-02-10 |
| 6 | Confirming The Effects of Acupuncture Treatments to Relieve Symptoms of Gulf War Illness PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This unblinded Phase II clinical trial will test the effects of individualized acupuncture treatments offered in extant acupuncture practices in the community; practitioners will have had at least 5 years of experience plus additional training provided by the study. Veterans with diagnosed symptoms of Gulf War Illness will be randomized to either six months of biweekly acupuncture treatments (group 1, n=100) or 2 months of waitlist followed by weekly acupuncture treatments (group 2, n=100). Measurements were taken at baseline, 2, 4 and 6 months. The primary outcome is the SF-36 physical component scale score (SF-36P). |
LISA J TAYLOR-SWANSON; | 2026-04-03 |
| 7 | A Multi-centre, Double-blind Randomised Controlled Trial to Compare Modafinil Versus Placebo Over 12 Weeks in Patients With Severe Fatigue and Inflammatory Bowel Disease (MFI): A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Fatigue is a big problem in people with inflammatory bowel disease (IBD). Even when IBD is well controlled, 50% of patients remain fatigued most of the time. Fatigue can be physical (e.g. feeling tired or weak) and mental (e.g. brain fog). However, there are no effective treatments for IBD fatigue. Modafinil is a medication that can rapidly improve fatigue. It usually acts within 30 minutes and improves wakefulness. It can also improve brain fog. Modafinil has been used for over 30 years in people with narcolepsy, … |
CALUM MOULTON; | 2025-12-22 |
| 8 | OutreAch MediCal Care for HousEbound Patients With Post-COVID-19 Syndrome or ME/CFS of Any Cause PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The significance of the Post-COVID Syndrome (PCS) has been widely acknowledged. Various efforts are made to find out about the pathomechanisms behind PCS and to establish therapies. One sub-group of PCS-patients, however, is generally excluded from any studies, and that are those who are unable to visit outpatient clinics or hospitals for diagnostic work up or participation in clinical trials, as they are unable to leave their home and to seek medical support on their own physical and mental capabilities. They are housebound, … |
MEIKE DIRKS; | 2026-01-21 |
| 9 | Chronic Infections and Inflammation in ME/CFS: An Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled. Volunteers will be observed and sampled over time to identify the long-terms biological drivers and impact of their condition. The overall goal is to understand the biological and physiological mechanisms that are driving this condition. |
MICHAEL J. PELUSO; | 2026-03-06 |
| 10 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial – Effect of Hyperbaric Oxygen Therapy for The Treatment of Post COVID Condition (RECLAIM-HBOT) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The RECLAIM study platform will be used to explore whether the use of Hyperbaric Oxygen therapy (HBOT) improves the symptoms of post covid cognitive dysfunction. Hyperbaric oxygen therapy is a well-established medical treatment. HBOT promotes healing by delivering a high concentration of oxygen into the body. This high level of oxygen has a number of known benefits, such as growth of new blood vessels, as well as regulating immune and inflammation responses. It helps protect the brain and other nervous tissue from inflammation. HBOT may also have antiviral effects. Collectively, … |
RITA KATZNELSON; | 2026-02-23 |
| 11 | Combine Effects of Senobi Exercise & Aerobic Exercises on Body Mass Index, Fatigue and Quality of Life in Polycystic Ovarian Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: One of the most prevalent endocrine system conditions affecting women of reproductive age is polycystic ovary syndrome (PCOS), also known as hyperandrogenic anovulation (HA) or Stein-Leventhal syndrome. This chronic and heterogeneous disorder manifests itself as menstrual dysfunction, infertility, hirsutism, acne, and obesity. This study will be randomized controlled trial and will be conducted in Qasim Sandhu medical complex, … |
WAJEEHA ZIA; | 2026-01-08 |
| 12 | Effects of Yiqi Fuyuan Paste Formula in Chronic Fatigue Syndrome: A Randomized Double-Blind Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if Yiqi Fuyuan Paste Formula (a traditional Chinese medicinal paste made from medicinal and edible Chinese medicines and health food like Ginseng Radix et Rhizoma, Astragali Radix et Rhizoma, Codonopsis Radix, Atractylodis Macrocephalae Rhizoma, Poria Cocos, Coicis Semen, Dioscoreae Rhizoma, Nelumbinis Semen, Angelicae Sinensis Radix, Lycii Fructus, Citri Reticulatae Pericarpium, Juglandis Semen, Longan Arillus, Sesami Nigri Semen, Jujubae Fructus, Glycyrrhizae Radix et Rhizoma, … |
XIAO TIAN ZHANG; | 2026-01-06 |
| 13 | Unravelling Health and Frequent Symptoms and Voice Characteristics Evolution Over Time of Users of The Long COVID Companion Application to Develop Voice Biomarkers of Frequent Long Covid-related Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The LIH DDP research team focuses its research topics on vocal biomarkers and Long COVID, among others. Voice is indeed a promising tool to monitor health, as it contains many information on our health and is easy to collect. The development of vocal biomarkers of Long COVID-related symptoms could improve the remote monitoring of the health status of people affected by this disease. The LIH developed the Long COVID Companion (LCC) app in collaboration with the ApresJ20 Long COVID patient association in France to support patients in their daily lives. LCC app users will be invited to participate in this study to collect voice recordings at the same time as health-related data. The objectives of this study are: Primary objective: To develop vocal biomarker candidates for the main Long COVID symptoms (fatigue, brain fog, respiratory problems, sleep issues, stress, anxiety,..) in a population of people with Long COVID. Secondary objectives: * to assess the intra-individual longitudinal evolution of voice characteristics of people with LC * to assess app usability and acceptability in the long-term. |
AURÉLIE FISCHER; | 2025-12-08 |
| 14 | Taurine Supplementation As A Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The COVID-19 pandemic has swept across the globe, affecting millions of individuals with varying degrees of severity. While many individuals recover from the acute phase of the infection, a significant proportion continue to experience persistent and debilitating symptoms long after the initial SARS-CoV-2 infection. This condition, known as Long COVID (LC) or sometimes referred to as Post-COVID Condition (PCC) or post-acute sequelae of COVID-19, has emerged as a complex multisystemic condition and challenging health issue, affecting approximately 10% of COVID-19 patients. Various symptoms characterize LC, including fatigue, sleep disturbances, cognitive impairment, … |
LAWRENCE RICHER; | 2026-03-16 |
| 15 | B-FREE Chronic Babesiosis Study: A Phase 2 Open Label Study of Tafenoquine for Treatment of Chronic Babesiosis Patients With Severe Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Phase 2 Open Label Study of Tafenoquine for Treatment of Chronic Babesiosis Patients with Severe Fatigue |
DAVID PUTRINO; | 2025-11-21 |
| 16 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cognitive problems and severe fatigue are two frequently occurring symptoms in long COVID, also known as Post-Covid Condition or Post-Acute Sequelae of COVID-19 (PASC), and their causes are currently unknown. Previous studies have shown reduced blood flow and increased inflammation in the brains of people with PASC. These brain processes are related to fatigue and cognitive problems. In other conditions, … |
SANDER VERFAILLIE; | 2025-12-19 |
| 17 | The Long COVID Treatment Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to determine whether a medicine called tirzepatide, also called Zepbound, can reduce symptoms of Long COVID. A randomized control trial will allow us to measure the effect of the treatment by having half of the participants take the medication and half take a placebo that has no medication. Participants will take the medication (or placebo) they are given and complete study surveys for 12 months. All of the study tasks are done remotely from the comfort of a participants home. |
JULIA MOORE VOGEL; | 2025-12-23 |
| 18 | Therapist-Guided Internet-Delivered Cognitive Behaviour Therapy (CBT) for Chronic Conditions (Chronic Conditions Course; CCC): Single-Group Predictors of Change in Routine Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic health conditions are common, disabling, and often co-occur with depression and anxiety. Internet-delivered cognitive behaviour therapy (ICBT) reduces barriers to treatment and has been adapted for chronic conditions. A transdiagnostic approach is promising because it is both effective and convenient in that clients with diverse conditions receive the same program. Both therapist-guided and self-guided formats have been found effective; however, … |
HEATHER HADJISTAVROPOULOS; | 2025-12-02 |
| 19 | Effectiveness and Safety of A Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise Vs Conventional Low-intensity Exercise on Fatigue and Related Variables in Patients With Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME) or Post COVID Syndrome (PCS) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, single-blind clinical trial that aims to evaluate the effectiveness of a tele-rehabilitation program based on mindful and conscious movement-based exercise (including adapted yoga, breathing exercises, and body awareness) compared to conventional exercise (low-intensity strength and aerobic training) and usual medical care (control group) over twelve weeks. The study is for people diagnosed with Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME) or Post-Covid Syndrome (PCS). We will also look at how the program affects the autonomic nervous system by measuring heart rate variability (HRV). All sessions will be delivered remotely via Telehealth, … |
HERMANN FRICKE COMELLAS; | 2026-03-30 |
| 20 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial – Effect of Hi-OxSR for The Treatment of Post COVID Condition (RECLAIM-HiOxSR) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The RECLAIM study platform will be used to explore whether the use of the Hi-OxSR device improves the symptoms of post covid cognitive dysfunction. Carbon dioxide (CO2) has been proposed as a potential treatment for persistent immune activation as there is evidence that CO2 has antioxidant, anti-inflammatory, and anti-cytokine effects. We conducted a pilot study assessing the open label use of re-breathing CO2 (using Hi-OxSR) twice a day for 14 days, … |
ANGELA M CHEUNG; | 2025-09-15 |
| 21 | Auricular Vagal Neuromodulation Therapy in Postural Orthostatic Tachycardia Syndrome: Physiological Mechanisms and Systemic Effects – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Autonomic nervous system imbalance causes postural tachycardia and related cardiac symptoms in Postural Orthostatic Tachycardia Syndrome (POTS). The impact of POTS is more far-reaching than postural tachycardia. Several systemic, autonomic symptoms along with neuro-cognitive dysfunction leading to poor quality of life contribute to significant disability in POTS. A combination of abnormal autonomic tone, abnormal cerebral blood flow regulation, … |
SATISH RAJ; | 2025-06-18 |
| 22 | Stimulation of The Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is testing whether a gentle electrical stimulation of a nerve in the ear, called the vagus nerve, can help reduce fatigue and improve symptoms in people with Post-COVID Syndrome or Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The treatment, known as transcutaneous auricular vagus nerve stimulation (taVNS), is non-invasive and can be done at home using a small device. Participants will try two different types of stimulation, called Intervention A and Intervention B, … |
ANDRÉ SCHULZ; | 2025-08-08 |
| 23 | Mind-Body in Long COVID and Myalgic Encephalomyelitis Study (MILES): A Patient-Centred RCT PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC). Our team recognizes that ME/CFS and Long COVID are serious, debilitating, biomedical conditions. ME/CFS can affect many different parts of the body, such as the nervous system, immune system, and metabolism. It is hypothesized that central sensitization (i.e., when nerves get too excited) may influence these complex conditions and may make symptoms worse. This study explores a mind-body program called the Dynamic Neural Retraining System™, or DNRS™. Mind-body interventions (MBIs) focus on how the brain, mind, body, … |
SUNITA VOHRA; | 2025-07-16 |
| 24 | Fatigue in Cerebral Palsy: An EEG- and FDG-PET-based Study of Brain Activity and Its Correlation With Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Persons with cerebral palsy (CP) commonly suffer from fatigue. Fatigue is an important cause of their reduced participation in work or social life. Traditionally, CP-related fatigue has been viewed as related to the person’s motor impairment. This view causes habilitation efforts to focus on muscle function. We hypothesize that the feeling of being fatigued must involve the activity of a specific, but un-identified, … |
BJØRNAR HASSEL; | 2025-12-19 |
| 25 | Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent An Exercise Test PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is a disease characterized by persistent and unexplained fatigue associated with diffuse pain, sleep disorders, neurocognitive and autonomic symptoms, musculoskeletal manifestations and digestive symptoms. A central feature of this disease is post-exertional symptom exacerbation, also referred to as post-exertional malaise, defined as the worsening or the appearance of symptoms after physical or mental exertion, … |
FRÉDÉRIQUE RETORNAZ; | 2026-03-24 |
| 26 | A Double-blind, Randomized Study to Evaluate The Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Long COVID is a condition where debilitating symptoms can persist for months after a COVID-19 infection. This study aims to evaluate the effects of NE3107 on several neurological symptoms reported in people with Long COVID including difficulty concentrating or remembering things (brain fog) and fatigue. Researchers will compare NE3107 to a placebo (a look-alike substance that contains no drug) to see if NE3107 works to treat neurocognitive and fatigue symptoms of long COVID. Participants will: * Take NE3107 or a placebo twice daily for 84 days * Visit the clinic 5 times for checkups and tests and have a follow up phone call |
BIOVIE | 2026-02-19 |
| 27 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study is conducted in New York, New York at The Cohen Center for Recovery from Complex Chronic Illness at Mount Sinai. This is an IND-exempt, off-label, multi-ascending, randomized, placebo-controlled clinical trial of sirolimus (also known as rapamycin) in adults with Long COVID. There are 2 arms: Sirolimus and Placebo. This study aims to evaluate the efficacy of Sirolimus in adults with Long COVID. Efficacy will be evaluated by measuring patient-reported outcomes in response to Sirolimus. |
DAVID PUTRINO; | 2025-07-18 |
| 28 | A Phase II, Multi-centre Open Label Study to Assess The Efficacy and Safety of Oral Apabetalone With Background Dapagliflozin in Subjects With Long -COVID-19 (Post-COVID-19 Conditions) and Type 2 Diabetes Mellitus (T2DM) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open label, multicentre, phase II clinical trial that aims to assess the efficacy and safety of oral Apabetalone with background dapagliflozin for up to 12 weeks in T2DM patients with a history of probable or confirmed SARS-CoV-2 infection, with symptoms within 3 months from the onset of COVID-19 that last for at least 2 months and cannot be explained by an alternative diagnosis. |
RESVERLOGIX | 2025-04-18 |
| 29 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of The Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The efficacy and safety of rituximab on ME/CFS symptoms after administration to patients with myalgic encephalomyelitis/chronic fatigue syndrome will be compared in an exploratory, placebo-controlled, double-blind fashion. In the subsequent secondary evaluation period, subjects who received rituximab in the primary evaluation period will receive placebo, and the timing and duration of rituximab’s effect will be explored throughout the entire evaluation period. Subjects who received placebo during the primary evaluation period will receive rituximab during the secondary evaluation period to explore changes in endpoints before and after switching from placebo to rituximab in the same subjects. |
TOMOKO OKAMOTO; | 2025-04-30 |
| 30 | Evaluation of The Relationship Between Craniovertebral Angle and Fibromyalgia Symptom Severity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Forward Head Posture Frequency in Fibromyalgia Patients Assessed by Craniovertebral Angle: Association with Symptom Severity. Forward head posture is more common in patients with fibromyalgia and is a factor that increases symptom severity. |
NADIDE KOCA; | 2025-12-01 |
| 31 | Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Long COVID is a complex condition that affects approximately 1.4 million Canadians following SARS-CoV-2 infection. Fatigue is the most common symptom of Long COVID. This feasibility trial will evaluate a new rehabilitation program called COVIDEx for treating fatigue after COVID-19, and compare its effectiveness to the standard treatment currently used. The experimental treatment group will receive an 8-week multi-modal rehabilitation program with two 50-minute sessions per week. 60 participants will be recruited, randomly assigned to the COVIDEx program or standard of care (SoC) and followed for 24 weeks. |
PAVLOS BOBOS; | 2025-08-01 |
| 32 | Development of A Regional Irritable Bowel Syndrome Cohort PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Setting up a regional (multicentre), longitudinal cohort of people suffering from irritable bowel syndrome followed up in consultation to study the natural history of the disease and its prognosis. |
UNIVERSITY HOSPITAL ROUEN | 2026-01-08 |
| 33 | Effectiveness of A Personalized In-home Telerehabilitation Program on Self-Care in Patients with Long COVID: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether a 12-week tele-rehabilitation programme with monitoring via a mobile app produces medium-term improvements in self-management, fatigue and quality of life in patients affected by persistent COVID. The main questions it aims to answer are: * Will a multimodal program (exercise with education) improve the self-management ability of patients with post-exertional malaise? * Does fatigue and quality of life will be improved in these patients? Researchers will compare an experimental breath program to a control standard care group to see if multimodal program works to treat post-exertion malaise. Participants will: * Follow-up 12 weeks online sessions: 1 weekly synchronous online session + 1 scheduled asynchronous session + educational resources * Daily use of the app: daily log, education and questions |
CEU SAN PABLO UNIVERSITY | 2025-02-18 |
| 34 | Amygdala Insula Retraining (AIR) in The Management of Mold Illness Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of the study is to compare a mind body intervention against usual care in patients with fatigue with mold illness. Our research questions include: * Is the mind body intervention additive to usual care in mold illness * Can the mind body intervention change self-reported overall wellness, and wearable device metrics such as heart rate variability |
CHRONIC CONDITIONS RESEARCH FUND | 2026-02-20 |
| 35 | Characterization, Treatment, and Long-term Follow-up of Fatigued Patients in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The overarching purpose of this project is to further the understanding of fatigue as a symptom in primary care patients, and to build evidence for a highly accessible treatment targeting fatigue that can be readily implemented in primary care clinics. Data will be collected within a randomized controlled superiority trial. The primary aim is to evaluate the effectiveness of a transdiagnostic cognitive behavioral therapy (tCBT) for fatigued patients as compared to care as usual (CAU). Primary outcome will be change in fatigue severity (as measured by the Checklist Individual Strengths, fatigue subscale) pre- to post-treatment (6 months), … |
ELIN LINDSÄTER; | 2026-03-11 |
| 36 | STUDY TO EVALUATE THE ROLE OF T CELL-DYSFUNCTION IN SYMPTOMS ASSOCIATED WITH LONG COVID, LYME DISEASE AND MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME USING THE VIRAXIMMUNE FLUOROSPOT T CELL ASSAY PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a longitudinal observational study recruiting individuals that have attended three clinical sites with symptoms associated with a diagnosis of long COVID, PTLDS or ME/CFS. The study will be a multi-centre study, with up to 160 male and female participants enrolled. Participants that experience symptoms considered to be associated with a diagnosis of long COVID, PTLDS or ME/CFS will consent to the study, and attend for two study visits (at study entry and 6 months) to complete a questionnaire related to their symptoms, … |
VIRAXBIO LABS | 2025-12-04 |
| 37 | Use of Transcutaneous Vagus Nerve Stimulation in Reducing The Symptoms of Long COVID Patients Who Fulfill Diagnostic Criteria for ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A prior open label study has shown that transcutaneous vagus nerve stimulation \[tVNS\] can improve the health of some patients with postacute sequelae of SARS-CoV-2 infection (PASC), severely affected enough to also fulfill criteria for myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). The purpose of this study is to compare two sets of stimulus parameters to determine the one that best improves the health-related quality of life of these patients over a period of 6-weeks. Patients using their assigned device for at least 30 of the 42 possible opportunities will receive the best device for an additional 6-week period. |
BENJAMIN NATELSON; | 2025-08-08 |
| 38 | Pilot Study on The Feasibility of An RCT: Evaluating Periodic Fasting As A Treatment Strategy for Long Covid in Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Long COVID, characterized by persistent symptoms following acute COVID-19 infection, has emerged as a significant public health concern. Symptoms range from fatigue, cognitive impairments, to respiratory difficulties, affecting patients' quality of life. Dietary interventions, particularly fasting, have historically been used to modulate immune responses and improve health outcomes in various conditions. The Buchinger-Wilhelmi method represents a structured and medically supervised fasting approach. Given the inflammatory nature of long COVID, fasting may offer therapeutic benefits by modulating the immune response, enhancing cellular repair mechanisms, … |
JOCHEN SCHNEIDER; | 2024-12-30 |
| 39 | Investigating The Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: * Long Covid (LC) * Post-treatment Lyme disease syndrome (PTLDS) * Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) |
DAVID PUTRINO; | 2026-03-13 |
| 40 | Effects of A Rehabilitation Programme Focused on Energy Management in People With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study focuses on rehabilitation nursing care for adults diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a home setting. The objective is to evaluate the effects of an individualised rehabilitation programme, which aims to empower participants to manage their energy effectively, observing the impacts on functionality and fatigue. |
ESCOLA SUPERIOR DE SAÚDE NORTE DA CRUZ VERMELHA PORTUGUESA | 2026-01-28 |
| 41 | Investigating The Feasibility of Repurposing HIV Antivirals in Adults With Long Covid PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The trial will test if two repurposed HIV antivirals can reduce symptom burden in adult participants with Long Covid compared to placebo. Viral infection and viral reactivation have been documented in Long Covid. Participants will be randomly allocated to receive antivirals, Truvada (tenofovir disoproxil/emtricitabine, TDF/FTC, Group 1) or Selzentry (Group 2), or a placebo (pill) (Group 3), taken daily for 90 days. |
DAVID PUTRINO; | 2026-03-13 |
| 42 | Comparison of The Effects of Inspiratory Muscle Training and Baduanjin Exercises on Pulmonary Function, Exercise Capacity and Quality of Life in Patients With Hypertrophic Cardiomyopathy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to compare the effects of inspiratory muscle training and Baduanjin exercises on pulmonary function, exercise capacity, and quality of life in patients with hypertrophic cardiomyopathy. By investigating these interventions, the investigators seek to introduce novel approaches that can enhance pulmonary function, exercise capacity, and overall quality of life for these patients. In the study, which will involve three groups-the control group, the inspiratory muscle training (IMT) group, and the Baduanjin group-it was calculated that a total of 51 patients, with 17 in each group (n = 17), … |
MUHAMMED YURTSEVEN; | 2025-11-30 |
| 43 | A Multi-center, Randomized, Double-blind, Positive Parallel Control Study of Compound Ciwujia Granules in The Treatment of Chronic Fatigue Syndrome (Spleen-kidney Deficiency Syndrome, Heart-spleen Deficiency Syndrome) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To observe the improvement of Chalder scale score in patients with chronic fatigue syndrome treated by Compound Ciwujia Granules. Improvement =\[(baseline score – post-treatment score)/baseline score\]\*100% |
XIAOTIAN ZHANG; | 2025-09-23 |
| 44 | Lifestyles Implemented-Survivorship Care Plan In Lymphoma Survivors: A Randomized Non-pharmacological Clinical Trial By The Fondazione Italiana Linfomi (FIL) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective randomized open-label, multicenter, 2-arm study to assess the role of healthy LifeStyle implemented Survivorship Care Plan (LS-SCP) in modifying the Quality of Life (QoL) in a population of long-term lymphoma survivors (in remission for a minimum 3 years since the last treatment and a maximum of 10 years). |
CARLA MINOIA; | 2026-01-12 |
| 45 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to determine if low-dose naltrexone (LDN) reduces fatigue, improves related symptoms, and reduces inflammatory markers in peripheral blood in cases with Post-COVID-19 Fatigue Syndrome (PCFS) from COVID-19 (i.e. confirmed SARS-CoV-2 case). LDN refers to naltrexone given in doses of 1-4.5 mg. Overall, studies have found that LDN is safe and well-tolerated. It may help to reduce pain and inflammation and improve well-being and immune function.The trial will be conducted by the Complex Chronic Diseases Program (CCDP) at BC Women’s Hospital and will demonstrate whether LDN could benefit a large number of people with PCFS. |
LUIS NACUL; | 2026-03-20 |
| 46 | Effect of Aerobic Training on Quality of Life in Elderly With Idiopathic Chronic Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: the study was conducted to evaluate the effectiveness of aerobic training for decreasing fatigue severity and increasing quality of life in elderly with idiopathic chronic |
OLA MOHAMED ELSAYED ELGOHARY; | 2024-03-25 |
| 47 | Pilot Study of An Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate The Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Long Covid is a multisystem condition comprising often severe symptoms that follow a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Long COVID often manifests as fatigue and neurocognitive impairment (also referred to as ‘brain fog’). Based on two systematic reviews of Covid-19 cases in neonates, children and adolescents under 19 years of age, fatigue caused by Long Covid can persist for years and can lead to work disability and labour shortages, posing a public health emergency with lasting health, mental, and economic impacts. To date, … |
ZAMIR HUSSAIN SUHAG; | 2024-12-01 |
| 48 | Hydrogen Water Dosing Study for ME/CFS and Chronic Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this 16-week pilot randomized trial is to explore the potential benefit of the OTC supplement hydrogen water, for the symptoms of chronic fatigue syndrome (CFS). Methods: This 16-week home-based trial will compare two groups: (1) low dose hydrogen water (2-3 glasses/day) for all 16 weeks; … |
FRED FRIEDBERG; | 2024-11-30 |
| 49 | A Feasibility Study Assessing The Acceptability, Adherence, and Safety of Photobiomodulation (PBM) Therapy and Objective Assessment Measures in Myalgic Encephalomyelitis (ME) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: There is no cure or approved treatments for ME. Several causes have been implicated in ME, including poor mitochondrial function. Mitochondria are the powerhouse of cells, producing energy. Therefore, loss of mitochondrial function and reduced energy production could be an explanation for the debilitating chronic fatigue that defines ME. The primary site of red light absorption in cells is the mitochondria. Mitochondrial red light absorption can boost energy production. Light therapy is already FDA approved for the treatment of acne, muscle and joint pain, arthritis, … |
SIMON CARDING; | 2024-02-01 |
| 50 | Phase 2a, Double-blind, Randomized, Placebo-controlled Trial of Methylprednisolone Versus Placebo in Patients with Cognitive Deficits in Post-COVID-19 Syndrome (PCS) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to learn about the therapeutic value of Methylprednisolone, a well-known immunosuppressant, on cognitive deficits in patients with post-COVID-19 syndrome (PCS). The main questions it aims to answer are: 1) Does Methylprednisolone improve memory function in PCS patients compared to placebo? 2) Does Methylprednisolone improve other patient centered outcomes in PCS patients such as fatigue, mood and quality of life compared to placebo? 3)What are the side effects of Methylprednisolone in this patient population, and how common are they? Participants in this study will be patients with PCS and cognitive deficits, … |
HEINRICH J AUDEBERT; | 2025-02-19 |
| 51 | An Alternative Approach to Fatigue and Comfort Levels in Hemodialysis Patients: Reiki Energy Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic renal failure (CRF) is a chronic and progressive kidney disease caused by impaired metabolic and endocrine functions as a result of a decrease in glomerular filtration rate (GFR), the role of the kidney in maintaining fluid electrolyte balance. KRG, which has high mortality and morbidity, is defined as an important public health problem due to the fact that it also causes a great burden on health systems. Reiki is not an alternative to allopathic medicine; … |
MERVE TOPAC; | 2024-09-04 |
| 52 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The overall goal of this study is to find out if rehabilitation exercise can help people who have long COVID. Participants will be randomized by chance to receive either aerobic exercise or breathing exercise (combined with stretches). Participants will be guided and supported in completing a tailored, 6-week home exercise program to be performed 5 – 6 days a week, prescribed and supervised by rehabilitation therapists. Participants will perform breathing exercises, which will be supervised by an occupational therapist. The focus of Aim 1 is to determine feasibility of implementing RESToRE in long COVID. |
ANNAMARIA R. NORWEG; | 2024-01-01 |
| 53 | Assessment of The Occurrence of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) in French Women Suffering From Endometriosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims at establishing the proportion of patients suffering from endometriosis and for whom an Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) diagnosis is established. The study participation will be offered to endometriosis patients displaying symptoms that may suggest an underlying OSAHS. OSAHS diagnosis will be made according to standard of care practice and patients will be followed up to 12 months after initiating the OSAHS treatment to fill in questionnaires assessing the impact of OSAHS treatment on various endometriosis-related symptoms |
ELSAN | 2025-10-01 |
| 54 | Exploring Worry in The Context of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Qualitative Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will be building on the findings of Kalfas et al 2022 paper exploring the prevalence of generalised worry in patients with Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) before and after Cognitive Behavioural Therapy (CBT). The research was conducted in South London and Maudsley NHS Foundation Trust’s (SLaM) Persistent Physical Symptoms Research and Treatment Unit. Previous research has indicated a bidirectional relationship between fatigue and worry (Kalfas et al., 2022); … |
KING’S COLLEGE LONDON | 2024-05-31 |
| 55 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn about the effectiveness of repeated immunoadsorption intervention in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS). The main questions it aims to answer are: (1) Does repeated immunoadsorption relieve fatigue and/or other symptoms associated with CFS and PACS-CFS? (2) Is repeated immunoadsorption safe and tolerable in this patient population? What are the side effects of repeated immunoadsorption, and how common are they? Participants will be asked to participate for approx. 32 weeks (8 months). After screening, … |
HARALD PRUESS; | 2026-01-16 |
| 56 | Observational Study of Hyperbaric High Pressure Oxygen Therapy (HBOT) in Patients with Post-COVID Syndrome (PCS) and Myalgic Encephalomyelitis/chronic Fatigue Syndrome (ME/CFS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this observational study is to document symptom progression in 60 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) who undergo Hyperbaric Oxygen Therapy (HBOT) following COVID or other infections. Participants will receive HBOT treatment as an additional option after completing the Chronic Fatigue Syndrome CARE (CFS_CARE) study and will be invited to take part in this observational study. Patients will complete health evaluations in the form of questionnaires, including the 36-Item Short Form Health Survey (SF-36), to assess changes in ME/CFS-related symptoms after HBOT. Rather than evaluating the efficacy of HBOT itself, … |
CARMEN SCHEIBENBOGEN; | 2025-02-12 |
| 57 | Unhide® Project Also Known As The Unhide® Solve Together Unified Platform PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years and older will provide self-reported health data, biometrics, and symptom diaries through the MyDataHelps™ app (branded as unhide® for this study). The goal is to create comprehensive longitudinal profiles to facilitate research into disease subtypes, causes, diagnostics, and potential treatments, … |
MEGAN L FITZGERALD; | 2026-01-22 |
| 58 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericiguat Compared to Placebo Tablets in Male and Female Participants Aged 18-50 Years With Post-COVID-19 Syndrome Without (PCS) or With (PCS/CFS) Fulfillment of ME/CFS Criteria (VERI-LONG) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main questions it aims to answer are: • Does Vericiguat relieve fatigue and/or other symptoms associated with post-COVID-19 syndrome? • What are the side effects of Vericiguat in this patient population; and how common are they? Participants will be asked to participate for approx. 18 weeks. After screening, participants will receive assigned intervention of either 10 weeks of treatment with Vericiguat or matching placebo tablet, … |
JUDITH BELLMANN-STROBL; | 2026-01-28 |
| 59 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine The Effects of Oxaloacetate on Improving Fatigue in Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Following acute COVID-19, some patients develop a group of debilitating symptoms that include fatigue, orthostatic intolerance, difficulty with attention and concentration (often called brain fog), myalgias and disrupted sleep. The term Long COVID is used to describe these symptoms after the initial viral infection has passed. These symptoms are the same as those that define myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A Proof of Concept trial showed significant fatigue benefit in Long COVID patients. This randomized, … |
LUCINDA BATEMAN; | 2025-02-04 |
| 60 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The researchers propose to develop a Canada-wide, adaptive randomized clinical platform trial to assess the effectiveness of various interventions in patients with lingering symptoms of COVID-19 (Long COVID). Participants will be randomized initially to 1 of 3 arms, including placebo (control) and 2 interventions. Because this is an adaptive trial, … |
ANGELA M CHEUNG; | 2026-02-23 |
| 61 | Amygdala Insula Retraining in The Management of Long COVID Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of the study is to compare a mind body intervention against usual care in patients with fatigue with long COVID. Our research questions include 1. Is the mind body intervention additive to usual care in long COVID 2. Can the mind body intervention change laboratory markers, heart rate variability and dysautonomia. |
LEONARDO TAMARIZ; | 2024-06-15 |
| 62 | A Single-blinded Sham-controlled Crossover Trial to Evaluate The Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the efficiency and safety of immunoadsorption for the treatment of post-COVID syndrome (PCS). Efficacy will be measured (1) subjectively as an improvement of the score of questionnaires like the multidimensional fatigue inventory (MFI-20), Chalder fatigue scale, Bell-score, … |
JULIA WEINMANN-MENKE; | 2025-07-28 |
| 63 | Efficacy of Baduanjin Qigong Exercise Plus Selected Exercise Program on Chronic Fatigue Syndrome and Postural Imbalance Following Lower Limb Burn Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: 90 patients who suffer from chronic fatigue syndrome and postural imbalance following Lower Limb Burn Injury. will be selected from outpatient clinic, faculty of physical therapy, Cairo university. Patients will be assigned randomly into 3 groups of equal numbers, group A: (Study group A) will receive Baduanjin Qigong exercise plus selected exercise program. group B:(Study group B) will receive Baduanjin Qigong exercise, Group C (control group C) will receive selected exercise program . |
KHADRA MOHAMED ALI; | 2023-12-30 |
| 64 | The Role of Epigenetic Mechanisms in Stress Intolerance in Patients With Chronic Widespread Pain PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Patients with chronic widespread pain (CWP) frequently experience stress intolerance – an exacerbation of symptoms in response to stress. Although it severely affects their quality of life, stress intolerance remains a mystery. Hence, unravelling the mechanisms underlying stress intolerance is crucial to understand CWP pathophysiology and to develop novel treatments. Epigenetic mechanisms hold the potential to provide an answer as they have been found to be altered in patients with CWP at baseline, and in response to stress. However, research on epigenetic mechanisms in CWP is very scarce. Hence, … |
JO NIJS; | 2025-09-19 |
| 65 | NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Gulf War illness (GWI) affects up to 210,000 U.S. veterans who served in the Middle East during the Gulf War in 1990-1991. Symptoms include fatigue, muscle and joint pain, forgetfulness, headaches, rashes, … |
BRIAN T WALITT; | 2026-04-01 |
| 66 | Connecting Breath and Mind: Development of An Online Holistic Treatment Programme Connecting Psychological Wellbeing and Breathing Techniques in Children and Young People With Long COVID PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Recruitment target: Phase I: Co-design of intervention: 5 to 15 CYP aged between 12-18 years of age referred to the pan-London long COVID MDT. Phase II: Randomised pilot: 40 patients (12-18 years) will be recruited from a potential pool of 214 patients referred to the pan-London long COVID MDT. Methods: Phase I: Co-design Design and setting The intervention will be co-designed with CYP following a process informed by practice-base evidence, which centres the voices and wisdom of CYP, focuses on creativity and playfulness, … |
ROYAL BROMPTON & HAREFIELD NHS FOUNDATION TRUST | 2024-03-30 |
| 67 | The COPE Study: Pilot Intervention to Improve Symptom Self-management and Coping in Adults With Post COVID PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project is a randomized controlled pilot trial using mixed methods to examine the feasibility, acceptability, and initial effects of a telemedicine group-based intervention designed to improve symptom management and coping in adults with Post-COVID. |
TRACY HERRING; | 2023-12-01 |
| 68 | A Naturalistic Efficacy Trial of The Norwegian Sickness Absence Clinic for Patients With Common Mental Disorder and Musculoskeletal Disorders PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The Norwegian Sickness Absence Clinic (NSAC) is a publicly funded specialist outpatient health service, which is uniquely available for the work force. The overall aim of the NSAC is prevention of sickness absence, promote return to work (RTW) among those on sickness absence and prevent long term disability benefit dependency. In addition to being a health service, the NSAC has a focus on work and functional recovery, including also non-health related factors. Patients can be referred by general practitioners for mental health problems and musculoskeletal problems. The NSAC has a lower threshold for severity than specialist health services generally, … |
ARNSTEIN MYKLETUN; | 2025-06-11 |
| 69 | Post-COVID-19 Chronic Fatigue Syndrome PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2. |
EMAD R ISSAK; | 2025-03-10 |
| 70 | Evaluating The Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of this study is to gather data and assess changes in patient-reported outcomes with the stellate ganglion blocks as treatment for their sympathetically-mediated long COVID symptoms. |
JONATHANN KUO; | 2025-03-13 |
| 71 | Enhanced External Counterpulsation (EECP/ECPT) to Treat Long-COVID-19 Fatigue – A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this double blind, outcome-assessor blind, randomized controlled trial, is to compare the effectiveness of external encounter counterpulsation (EECP) versus sham procedure in participants with long COVID-19 fatigue. The main question[s] it aims to answer are: – Whether EECP improves fatigue score – Whether EECP improves quality of life, six-minute walk test, and endothelial function Participants will attend 15 sessions (1-hour each) of EECP during 5 weeks Researchers will compare EECP versus sham procedure for the above outcomes. |
DAFNA YAHAV; | 2024-07-01 |
| 72 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to study the effects of stellate ganglion block (SGB) in participants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The main questions it aims to answer are: Does SGB treatment improve symptoms of ME/CFS (e.g. brain fog, fatigue)? Do changes in symptoms go along with changes in blood or saliva? Participants will receive a total of six blocks over three weeks (one block on each side, one day apart, per week). Prior to treatment and at two points following treatment, participants will complete surveys, take a cognitive (puzzle type) test, … |
DEBORAH L DURICKA; | 2024-01-01 |
| 73 | Effects of A Functional Re-education and Environmental Adaptation Programme on Levels of Dependency, Dyspnoea, Functional Capacity, Quality of Life and Caregiver Burden in Cancer Patients With Associated Respiratory Pathology PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: the investigators propose an interdisciplinary intervention, carried out by occupational therapists, nurses, physiotherapists and doctors specialised in this type of patient, aimed at improving conventional clinical practice and implementing a programme of functional re-education and environmental adaptation that implements conventional clinical practice, and which the investigators also consider to be an essential intervention in the follow-up of patients with associated respiratory pathology once they are discharged from hospital. |
EDUARDO J FERNÁNDEZ RODRÍGUEZ; | 2023-12-31 |
| 74 | The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical study aims to evaluate the use of i3.1 probiotic in participants who meet the Institute of Medicine (Canadian Consensus Criteria) case definition for ME/CFS and who may or may not be diagnosed with irritable bowel syndrome (IBS). The main questions it aims to answer are: * how effective is the usage of the i3.1 probiotic to reduce gastrointestinal (GI) inflammation and normalize the GI and systemic/brain interface? * how well is it working on IBS severity? The study sample is 100 male and female participants aged 45 to 70 years with ME/CFS (per the Canadian Consensus Criteria); … |
NANCY KLIMAS; | 2025-03-04 |
| 75 | In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To date, little is understood regarding post-COVID fatigue or cancer fatigue though it is known to affect a large proportion of patients (10-70% depending on the population). This study aims to investigate potential mitochondrial function and metabolic changes in brain to provide further information regarding the etiology of these changes leading to fatigue. This study hypothesized that Post-COVID fatigue is ensued by perturbations in metabolism and mitochondrial function in the brain. This is a case-control study. In this study, … |
JEONG HOON K LIM; | 2023-12-08 |
| 76 | EFFECTS OF VAGUS NERVE STIMULATION IN POST COVID-19 SYNDROME: A RANDOMIZED CONTROLLED TRIAL PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to increase parasympathetic activity and decrease the severity of symptoms by providing vagal stimulation with the t-VNS method in order to suppress the increased sympathetic activity in patients with prolonged Covid symptoms.The main question[s] it aims to answer are: Question 1:Is left ear transcutaneous vagus nerve stimulation effective in suppressing the symptoms of patients in Post Covid syndrome? Question 2:Is bilateral auricular transcutaneous vagus nerve stimulation effective in suppressing the symptoms of patients in Post Covid syndrome? A 5-minute heart rate variability measurement will be performed to measure the effectiveness of vagus nerve stimulation in participants.HRV is a non-invasive method used to evaluate ANS activity and is a measure of heart rate change over a period of time |
ALPER PERCIN; | 2023-01-04 |
| 77 | A Randomized, Placebo-controlled, Double-blind Crossover Study to Evaluate Efficacy of EnXtra on Accuracy & Reaction Time, Perceived Alertness & Digital Fatigue for Video Gamers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In the present study, Sponsor aim to evaluate the effects of EnXtra® as to improve Accuracy & Reaction Time, Perceived Alertness & Digital Fatigue for Video Gamers. A Randomized, Placebo-controlled, Double-blind Crossover Study of 60 randomized cross over for total study duration of approximately 25 days with 5 days of treatment period for each arm and 5-7 days wash out period between both arms. |
SHALINI SRIVASTAVA; | 2023-02-10 |
| 78 | Effect of Intensive Combined Rehabilitation Therapy for Patients With Post COVID 19 Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the effect of intensive combined rehabilitation therapy in form of Graded Exercise Therapy (GET) , Cognitive Behavioral Therapy (CBT) to treat patients with post COVID19 chronic fatigue syndrome . |
SAMAR HOSNY; | 2023-10-01 |
| 79 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: A Randomized, Double-blind, Placebo-controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the study is to investigate the effects of oral melatonin and zinc supplementation on core features in individuals with ME/CFS |
JOSÉ ALEGRE; | 2024-12-31 |
| 80 | Effectiveness of A 3-months Dietary Supplementation Based on Quercetin Phytosome®) for The Treatment of Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate whether a 3-month period of quercetin supplementation (500 mg of Quercetin Phytosome®) is useful in the treatment of chronic fatigue, as assessed by the Fatigue Impact Scale (FIS-40). Secondary end points are sleep assessment through Pittsburgh Sleep Quality Index (PSQI) and muscle performance assessment through the Short Physical Performance Battery (SPPB) and body composition assessment using DXA. |
AZIENDA DI SERVIZI ALLA PERSONA DI PAVIA | 2023-01-31 |
| 81 | Observational Study of Repeat Immunoadsorption (RIA) in Post Covid ME/CFS Patients with Elevated ß2 Adrenergic Receptor Autoantibodies PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The evidence for an autoimmune etiology in postinfectious myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is growing. The investigators observed in a not yet published study that in ME/CFS triggered by COVID, similar to ME/CFS after other infections, there is a close correlation of ß2 adrenergic receptor (ß2R) autoantibodies with symptom severity. Immunoadsorption (IA) to remove autoantibodies has been used successfully in many autoantibody-mediated diseases. The investigators have already performed two proof of concept studies of IA in postinfectious ME/CFS with elevated ß2R antibodies, … |
CARMEN SCHEIBENBOGEN; | 2025-02-13 |
| 82 | Interoception in Patients With Medically Unexplained Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about interoception in patients with stress related syndromes (overstrain, burnout; SRS) and functional disorder (fibromyalgia/ chronic fatigue syndrome; FD). The main questions it aims to answer are: – Is there a significant difference in interoception between patients with SRS and healthy controls? – Is there a significant difference in interoception between patients with FD and healthy controls? – … |
INDRA RAMAKERS; | 2024-06-30 |
| 83 | Association of Silicone Breast Implant Reconstruction and -Enlargement With Overall Wellbeing, Lymphoma and Auto-immune Disease – Breast Implant Illness PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Implant-based breast reconstructions contribute considerably to the quality of life of breast cancer patients. A knowledge gap exists concerning the potential role of breast implants in the development of so called ‘breast implant illness’ and autoimmune diseases in breast cancer survivors with a silicone breast implant-based reconstruction. Breast implant illness is a constellation of non-specific symptoms reported by a small group of women with silicone breast implants. Methods/Design: The Areola study is a multi-centre historic cohort study with prospective follow-up aiming to assess the risk of ‘breast implant illness’ and autoimmune diseases in female breast cancer survivors with and without silicone breast implants. The cohort consists of breast cancer survivors who received surgical treatment with silicone implant-based reconstruction in six major hospitals across the Netherlands in the period between 2000 and 2015. As comparison group, a frequency-matched sample of breast cancer survivors without breast implants will be selected. An additional group of women who received breast augmentation surgery in the same years will be selected to compare their characteristics and health outcomes with those of breast cancer patients with implants. All women still alive will be invited to complete a web-based questionnaire covering various health related topics. The entire cohort including deceased women will be linked to the population based computerized databases of Statistics Netherlands. These databases include a registry of diagnostic codes, a pharmacotherapeutic prescriptions registry and a cause-of-death registry in which diagnoses of autoimmune diseases will be identified. Outcomes of interest are the prevalence and incidence of BII and the prevalence and incidence of autoimmune diseases. In addition, risk factors for the development of BII and autoimmune disorders will be assessed among women with implants. Discussion: The Areola study will contribute to the availability of reliable information on the risks of breast implant illness and autoimmune diseases in Dutch breast cancer survivors with silicone breast implants. This will inform breast cancer survivors and aid future breast cancer patients and their treating physicians to make informed decisions about reconstructive strategies after mastectomy. Keywords: Silicone breast implants, Breast reconstruction, Breast cancer, Breast Implant Illness, Autoimmune disease |
SANNE SCHAGEN; | 2025-06-01 |
| 84 | Study to Determine The Effectiveness of Therapy Methods (Acceptance Commitment Therapy, Micro Breaks) in Patients With Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a distinct disease entity with an estimated prevalence of 0.3-0.7% and more common in women (3:1 ratio). It can be diagnosed according to the Institute of Medicine (IOM) 2015 consensus definition using 3 major criteria and one of 2 minor criteria. Diagnosis requires that the patient have the following three symptoms: 1. A substantial reduction or impairment in the ability to engage in pre-illness levels of occupational, educational, social, or personal activities that persists for more than 6 months and is accompanied by fatigue, which is often profound, … |
SARAH SCHIEBLER; | 2024-12-01 |
| 85 | Vagus Nerve Stimulation As Treatment for Long Covid PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Many patients do not recover following Covid infection. The resulting illness is called Long Covid. Because there is no agreed upon treatment for this ailment, the research team has decided to do an open label pilot study using non-invasive, transcutaneous stimulation of the auricular branch of the vagus nerve. Inclusion criteria required the patient to fulfill criteria for having chronic fatigue syndrome. To date, fourteen patients provided evaluable data. Eight of these fulfilled the study’s requirements for treatment success. |
BENJAMIN NATELSON; | 2022-11-01 |
| 86 | Biofeedback and Hydrogen Water As Treatments for Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this 10-week pilot study is to explore the potential benefit of two recently developed non-invasive interventions, heart rate variability biofeedback (HRV-BF) and OTC supplement hydrogen water, for the symptoms of chronic fatigue syndrome (CFS). Symptom measures and heart monitoring information will be generated by this study. Given the lack of effective treatments in this illness, these two non-invasive home-based treatments may help patients feel and function better. |
FRED FRIEDBERG; | 2023-05-23 |
| 87 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID – A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Inpatient, multimodal rehabilitation represents one of the most important interventions in the disease management of post/long COVID. Different professional societies, including the German Society of Pneumology and the European Respiratory Society, recommend rehabilitation intervention to reduce the sequelae of COVID-19. However, from the perspective of science and practice, there are relevant areas that have been insufficiently investigated and are essential for the treatment success of post/long COVID patients: * Differentiation of rehabilitation effects from natural recovery after COVID-19. * Lack of personalized and symptom-based treatment approaches that can address the heterogeneity of symptoms in post/long COVID * Lack of uniform, … |
ANDREAS REMBERT KOCZULLA; | 2025-03-28 |
| 88 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of The Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for The Treatment of Patients With Post-COVID Asthenic Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: to assess executive network using resting-state fMRI and patterns of brain activation using task fMRI with a cognitive paradigm, against the background of taking the drug in comparison with placebo in patients with post-COVID asthenic syndrome. |
MARINE TANASHYAN; | 2022-12-20 |
| 89 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Coronavirus-2019 (COVID-19) is a viral disease leading to respiratory dysfunction, but it may also affect the brain and result in the development of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This may be the result of the COVID-19 virus infecting regions of the brain responsible for respiratory control. The symptoms of COVID-19 long haulers and ME/CFS may be lessened via an 8-week inspiratory muscle training protocol which is a simple and easy training protocol which can be done at a patient’s home. Thus, … |
HEATHER EDGELL; | 2024-01-31 |
| 90 | The Effects of Inspiratory Muscle Training Immediatley After Lung Transplantation: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Following lung transplantation (LTX), patients may exhibit respiratory and skeletal muscle weakness that will affect exercise capacity, increase dyspnea and fatigue, limit activities of daily living (ADL) and decrease quality of life. Inspiratory muscle training (IMT) has been extensively studied in a variety of non-LTX populations and research has shown that IMT improves exercise capacity, diaphragmatic thickness, … |
CRISTIANE MEIRELLES; | 2025-12-18 |
| 91 | Central Sensitization and Releated Factors in Medical Students: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Central sensitization (SS); is a physiological phenomenon caused by neuronal dysregulation and hyperexcitability in the central nervous system, resulting in hypersensitivity to painful and painless stimuli.Central sensitization syndromes (CSS); defines disorders in which SS originates and cannot be medically explained by any organic cause. CSS include clinical conditions such as fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), temporomandibular joint disorders (TMD), migraine/tension type headache, irritable bowel syndrome (IBS), restless legs syndrome (RLS). These disorders have many common clinical features such as pain, fatigue, sleep disturbance, increased sensitivity to painful and painless stimuli, coexistence, paresthesia, psychosocial disorders, … |
NIHAN ERDINC GUNDUZ; | 2022-07-01 |
| 92 | Effects of Balneotherapy for Patients With Post-COVID Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized controlled study is to evaluate the effects of balneotherapy (BT) and aquatic exercises in patients with post-acute COVID syndrome (PACS). The main question it aims to answer are: • Does BT and aquatic exercises alleviate some of the most prevalent features that characterize post-acute COVID syndrome? Participants allocated to the intervention group will undergo 3 weekly sessions of BT and aquatic exercises on alternate days in groups of 8 during 4 weeks. Prior the beginning of the intervention, … |
XAVIER NOGUÉS SOLAN; | 2023-01-31 |
| 93 | A 3-day Course for Adults With Chronic Fatigue Syndrome/Myalgic Encephalopathy (CFS/ME): A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) can be a serious and disabling condition with a heavy symptom burden and low function. Work disability is common, and social life dramatically affected. CFS/ME is a challenging health problem as well as a societal problem. In recent years, a doubling of the number of patients with a CFS/ME diagnoses has been reported in Norway. The patient group represents a challenge for the health care system, the municipality, and the Norwegian Labour and Welfare Organization (NAV). According to new figures, … |
LEIF EDWARD OTTESEN KENNAIR; | 2025-11-26 |
| 94 | A Randomized Double Blind Placebo Controlled Trial to Determine The Effects of Oxaloacetate on Improving Fatigue in ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: There is no approved treatment for fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a condition with as many as 2.5 million people in the US. Initial case studies have shown an improvement in fatigue in ME/CFS with anhydrous enol-oxaloacetate (AEO). This randomized, double blinded, placebo controlled trial will seek to further evaluate the efficacy of AEO to reduce fatigue in ME/CFS, based on change in the Chalder Fatigue Score (Likert Scoring) of the AEO group against the placebo group at 90 days. As secondary evaluations on other core ME/CFS symptoms, … |
SUZANNE D VERNON; | 2025-02-04 |
| 95 | Obstructive Sleep Apnea in Patients With Long COVID-19 Fatigue: A Multicentre Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Identify the relationship of obstructive sleep apnea (OSA) prevalence with post-COVID-19 fatigue that remains at least six months after acute disease |
LIGIA PIRES; | 2023-01-30 |
| 96 | Factors Associated With Hospitalization for Dengue and Dengue Severity: Hospital-based Cohort Study on Reunion Island PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In recent years, dengue has become endemic on La Réunion island, which has led to subsequent increase of secondary dengue infections, higher severity and higher mortality of the cases referred to the hospital. This project will investigate the factors associated with the hospitalization for dengue and the factors associated with dengue severity in a hospital-based cohort study conducted over two dengue seasons, as well as the long-term outcomes over aN18-month follow-up. |
CENTRE HOSPITALIER UNIVERSITAIRE DE LA RÉUNION | 2023-10-01 |
| 97 | Amygdala and Insula Retraining (AIR) Program and HUS Internet Therapy Compared to Treatment As Usual in Bodily Stress Syndrome, Fibromyalgia, Post Covid-19, and Chronic Fatigue Syndrome (ME/CFS) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will compare an Amygdala and insula retraining (AIR) program to an internet therapy developed at Helsinki University Hospital. The study will be a multi-center randomized controlled trial. Study units will be recruited from the Network for Functional Disorders that is hosted by the HUS Clinic for Functional Disorders and potentially later from international collaborators. The trial will clarify whether internet-based non-drug based therapies are helpful in overcoming the central sensitization and the functional disabilities caused by these disorders. |
HELENA LIIRA; | 2024-12-31 |
| 98 | The Role Of Central Sensitisation In Women With Endometriosis: A Prospective Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Gathering some information obtained during the gynaecological examination and transvaginal ultrasound check-up to be able to assess the prevalence of Central Sensitisation Syndrome (CSS) in women with endometriosis and also to be able to assess related risk factors. CSS has been defined as an algic syndrome due to a hyperactivation of the sensitivity circuit at a central level; the diagnosis is based on the result obtained from a questionnaire, the Central Sensitisation Inventory (CSI), which evaluates the presence and intensity of 25 clinical symptoms. For this reason, … |
DIEGO RAIMONDO; | 2025-01-31 |
| 99 | Effectiveness of Aerobic Exercises and Laughter Yoga Compared With Yoga in Anxiety and Depression Levels of Breast Cancer Survivors; A Double-blind Three Arm Clinical Trial Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 90% of breast cancer survivors experience cancer-related fatigue which decreases the physical activity. Moreover, due to the cancer treatments depression and anxiety will be happened. Previous studies showed the effect of physical activity on reduction of depression and anxiety; therefore the aim of this study is to evaluate the effectiveness of aerobic exercises and laughter yoga compared with yoga in anxiety and depression levels in breast cancer survivors. |
FATEME ABEDINI; | 2022-07-29 |
| 100 | Natural History of Post-Coronavirus Disease 19 Convalescence at The National Institutes of Health PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Background: People who get COVID-19 have a wide range of symptoms. They also recover from COVID-19 in different ways. In this study, researchers will use survey data to describe the different ways people experience and recover from COVID-19. They will also use the data to help create future studies to understand why some people do not fully recover. Objective: To learn more about the range and timing of symptoms that people have before, during, … |
BRIAN T WALITT; | 2026-03-13 |
| 101 | Water and Land-based Exercise for Children With Post COVID-19 Condition PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The latest data indicate that post COVID-19 condition is frequent in children and adolescents, with the most common symptoms being fatigue, shortness of breath, exercise intolerance and weakness. Evidence that COVID-19 can have significant long-term effects on children’s health highlights the need for measures to reduce the impact of the pandemic on children, ensuring that they receive appropriate treatments. Those experiencing post COVID-19 condition require more tailored exercise-related advice and improved support to be able to resume activities important to their individual well-being. To the best of our knowledge, … |
ANNA OGONOWSKA-SŁODOWNIK; | 2022-06-30 |
| 102 | Chinese Medicine for Residue Symptoms of COVID-19 Recovered Patients- A Double-blind, Randomized, Placebo-controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: COVID-19 has spread rapidly and now affects all over the world. On 11 March 2020, coronavirus disease 2019 (COVID-19) was declared a global pandemic by the World Health Organization (WHO). Most of the infected people will develop mild to moderate illness, for example fever, cough, tiredness and joint pain etc. For some older people, and those with comorbidities like cardiovascular disease, diabetes, chronic respiratory disease, and malignancy are more likely to develop serious illness. Also long-term problems such as fatigue, … |
LIN ZHIXIU; | 2023-06-30 |
| 103 | Design and Validation of An Energy Level Diary for Fatigue Management in Patients With Post-COVID Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Post-COVID-19 Syndrome (PCS) is characterized by symptoms, including fatigue, reduced physical performance, dyspnea, cognitive impairment, and psychological distress. Pateints have difficulties with energy management and often feel drained even after simple motor or cognitive tasks, which often leads to so called Crashes, after which patients are often bedridden for several day. This study examined wether an energy diary would facilitate the process of pacing during rehabilitation and beyond. |
UNIVERSITY OF WITTEN/HERDECKE | 2025-03-19 |
| 104 | POTS-CFS Study: A Case-Control Study on Exertion and Orthostatic Intolerance in The Context of Pediatric ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Pilot-case-control study on exertion and orthostatic intolerance of adolescents with myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) compared to age-matched healthy controls (HC). |
TECHNICAL UNIVERSITY OF MUNICH | 2022-11-22 |
| 105 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder, Multiple Chemical Sensitivityor Post Covid Compared to Healthy Controls – The Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Functional somatic disorders (FSD) are frequent in all medical settings and characterized by persistent physical symptoms that cannot be explained by other somatic or psychiatric conditions. In recent decades, a number of different types of functional somatic disorders have been defined, but so far there is no clear explanation for the pathophysiology. The high prevalence of olfactory problems in some patients with FSD suggests that olfactory symptoms are a potential diagnostic biomarker, especially in patients with multiple chemical sensitivity (MCS) and/ or post-covid. The olfactory system is a unique sense with direct pathways to the limbic system, … |
LISE GORMSEN; | 2025-05-08 |
| 106 | Effectiveness and Health Benefits of A Nutritional, Chronobiological and Physical Exercise Primary Care Intervention in Fibromyalgia and Chronic Fatigue Syndrome: SYNCHRONIZE + Mixed Methods Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic pain, fatigue and insomnia are classical symptoms of Fibromyalgia and Chronic Fatigue Syndrome, affecting seriously life quality. Non-pharmacological multicomponent approach is gaining relevance in Fibromyalgia treatment. However, nutrition and chronobiology are often not approached in-depth despite their potential. Furthermore, programs addressed to Chronic Fatigue Syndrome are still scare. This study aims to evaluate the effectiveness of a compact multidisciplinary group intervention based on nutrition, chronobiology and physical exercise in the improvement of lifestyle and life quality in Fibromyalgia and Chronic Fatigue syndrome. |
NOÈLIA CARRASCO-QUEROL; | 2024-03-01 |
| 107 | Long-term Sequelae of COVID-19 (Myalgic Encephalomyelitis): An International Cross-Sectional Study PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The term recovery from COVID-19 caused by SARS-CoV-2 is unverified because the infection leaves many symptoms due to permanent effects on multiple organs; The primary objective of this research is to understand acute and chronic long COVID symptoms by asking questions detecting patient’s experience especially symptoms lasting for several months which is known as chronic fatigue syndrome(Myalgic encephalitis). The study focuses on symptoms describing Myalgic encephalitis which may still affect COVID patients for several months after the infection along with making a big picture about rare symptoms that may the patient experienced during or after the infection. A secondary objective of this research is to focus on the long-term sequelae effects and comorbidities following COVID-19 vaccination. |
AHMED SHAHEEN; | 2025-07-03 |
| 108 | A Longitudinal Study on Longstanding Complicated Fatigue: Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS), Burnout Syndrome and Post-covid Fatigue PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to investigate if there are common biopsychosocial vulnerability factors for developing and maintaining fatigue, regardless of the diagnosis. The investigators also believe that subgroups differ in terms of these factors. Participating patients with ME/CFS, burnout syndrome and post-covid fatigue complete a web form at inclusion and after 1, 2, 4, 6, 12, … |
ANNA ANDREASSON; | 2025-05-22 |
| 109 | Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME) By Lipidomics, Metabolomics, Microbiome and Exome Analysis and Investigation of Clinical Improvement Under Administration of Probiotics PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue Syndrome (CFS/ME) by Lipidomics, Metabolomics, Intestinal and Peritoneal Microbiome Analysis and Exome Analysis and Investigation of a Possible Benefit of Probiotics. |
MICHAEL JELDEN; | 2022-12-01 |
| 110 | Influence of Co-diagnosis of Chronic Fatigue Syndrome in Patients With Fibromyalgia on Physical Activity, Quality of Life and Immunoneuroendocrine Response PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate differences in neuroimmunoendocrine response and quality of live in patients diagnosed with Fibromyalgia, with or without a co-diagnosis of Chronic Fatigue Syndrome. |
EDUARDO OTERO CALDERÓN; | 2023-11-16 |
| 111 | Exploring The Biological Basis of Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To collect blood and urine samples from patients with Chronic Fatigue Syndrome (CFS), myalgic encephalomyelitis (ME), and SEID (Systemic Exertion Intolerance Syndrome) and controls for genomic, viral and metabolomic testing. |
DXTERITY DIAGNOSTICS | 2021-12-01 |
| 112 | Technology Assisted Solutions for The Recognition of Objective Physiological Indicators of Post-Coronavirus-19 Fatigue PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Preliminary research from our group indicates that up to half of COVID-19 patients are experiencing symptoms consistent with severe fatigue a median of 10 weeks after their initial illness, while almost one third of those previously employed have not returned to work. At present, most clinical and research measurements of fatigue have relied upon self-reported perception of sensations such as exhaustion or weariness. Using such tools, there is an inherent challenge for clinicians in differentiating between patients who are experiencing fatigue at a psychosocial level, … |
ROMÁN ROMERO ORTUÑO; | 2021-11-05 |
| 113 | Neurologic Symptoms After Non-severe COVID-19 : Analysis and Diagnosis Assessment of Somatic Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A growing number of studies highlight the persistence of symptoms after the acute phase of SARS-CoV-2 infection, including in outpatients with mild to moderate forms of the disease. More than 80% of patients with persistent post-COVID-19 symptoms reported neurologic and neurocognitive disturbances. The pathophysiological mechanism is currently unknown, … |
CENTRE HOSPITALIER DE SAINT DENIS | 2021-10-30 |
| 114 | The ME-SH (Myalgic Encephalomyelitis in Stockholm-Harvard) Study: Structural Problems in Brainstem and Cervical Spine Cord in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome(ME/CFS) – A Case-control Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A case control study on patients with ME/CFS and healthy controls on prevalence of cervical obstructions, Cerebro spinal fluid (CSF) pressure and laboratory findings. |
BRAGEE CLINICS | 2026-03-31 |
| 115 | A Double-Blind, Randomized, Placebo-Controlled, Single-Center, Flexible Titration Study Evaluating The Efficacy of Solriamfetol in Treating Fatigue and Cognitive Symptoms in Adults Aged 18-65 Years With A Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is an 8-week single center, randomized, double-blind, placebo-controlled, flexible titration trial evaluating the efficacy of solriamfetol in the treatment of fatigue symptoms in adult patients with chronic fatigue syndrome. Subjects will be randomized to a solriamfetol group or placebo group. The investigators will utilize an intent to treat model and impute data. The overall goal of this study is to determine the efficacy and effectiveness of solriamfetol for treating chronic fatigue syndrome. |
JOEL L. YOUNG; | 2022-01-01 |
| 116 | SingStrong: Strong Lungs Through Song PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Evidence is emerging that many individuals who recover from Covid-19 are experiencing a range of residual problems. These include fatigue, pain, reduced exercise tolerance and breathing issues. This study includes participants who are experiencing problems with their lungs such as breathing difficulties, shortness of breath, … |
ROISIN CAHALAN; | 2021-09-01 |
| 117 | The Influence of Epigenetic Modifications and Post-Exertional Malaise in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Exploring epigenetic mechanisms of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is crucial to understand the mechanisms underlying its pathophysiology. Three potential candidates have been selected (BDNF, COMT, and HDAC genes). DNA methylation in the promoter regions of those genes will be explored. The investigators designed a randomised controlled trial and will enrol 70 patients with ME/CFS and 35 age-, sex-, … |
ANDREA POLLI; | 2022-09-30 |
| 118 | Risk Factors for Post-coronavirus Disease-2019 Fatigue: A Prospective Case-control Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background: COVID-19 is consistently spreading throughout the world, and the number of recovered patients is steadily increasing. Accordingly, a significant number of individuals will develop persisting post-COVID symptoms, while many of them will report on lasting fatigue. The main objective of the current study is to assess risk factors for the development of post-COVID-19 fatigue symptoms. As a secondary aim, the current study is intended to identify pathophysiology and explanatory mechanisms for the post-COVID-19 fatigue. Study design and population: a nested case-control study will be conducted at Rabin Medical Center (RMC), … |
RABIN MEDICAL CENTER | 2021-08-24 |
| 119 | Neuroinflammation in Chronic Systemic Symptoms (CSS): Proof-of-Concept Study Using PET and EEG/ERP Biomarkers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS). |
POPPY SCHOENBERG; | 2021-12-07 |
| 120 | Central Sensitisation in Post Covid-19 Infection Patients: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate whether there are indicators of central sensitisation in patients post covid-19 infection. |
MARC SCHILTZ; | 2023-01-01 |
| 121 | Central Sensitisation in Post Covid-19 Infection Patients: A Cross-sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate whether there are indicators of central sensitisation in patients post covid-19 infection. |
MARC SCHILTZ; | 2022-01-01 |
| 122 | Study to Investigate The Benefits of Dietary Supplement Quercetin for Early Symptoms of COVID-19 PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Quercetin is a flavonoid dietary supplement that occurs in many edible fruits and vegetables. It has remarkable antioxidant, anti-inflammatory, immunoprotective and antiviral properties. It is widely used to boost the body immune system against infections and keeping healthy life-style. The purpose of the present study is to investigate the potential benefits of quercetin for preventing COVID-19 disease progression and symptoms improvement in the early stage of infection. |
KING EDWARD MEDICAL UNIVERSITY | 2021-08-29 |
| 123 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: A Prospective Randomized Controlled Crossover Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In this study patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) will receive bright light therapy through portable lamps for 2 weeks. They will either start with this treatment and then go through a wash-out period of two weeks followed by a wait period of two weeks or they will start with the wait period, followed by a wash-out period, followed by the treatment phase. Patients are asked to fill out questionnaires (rating their level of fatigue) and they go through a standardized computer test assessing their attention levels, … |
STEFAN SEIDEL; | 2024-03-25 |
| 124 | Innovative Support for Patients With SARS-COV2 Infections (COVID-19) Registry (INSPIRE) PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The Innovative Support for Patients with SARS COV-2 Infections Registry (INSPIRE) study is a CDC-funded COVID-19 project to understand the long-term health outcomes in recently tested adults, both negative and positive, who have suspected COVID symptoms at the time of their test. Participants will complete short online surveys every 3 months for 18 months, share information about their health using a secure web-based platform, and are compensated for their time. |
MICHAEL GOTTLIEB; | 2025-11-14 |
| 125 | Assessing Neuroinflammation in Gulf War Illness With Whole-Brain Magnetic Resonance Spectroscopy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim of this study is to determine if Gulf War Illness (GWI) likely involves neuroinflammation. The investigators hypothesize that GWI involves neuroinflammation. By assessing the five neuroinflammatory outcomes across the brain, the investigators can determine if there are focal or global signs of one or more neuroinflammatory markers in the brains of individuals with GWI. This neuroimaging technique may allow investigators and others to detect cases of GWI neuroinflammation, which would improve treatment decisions as well as the development of new targeted therapies. It is an ideal diagnostic tool because it has low patient risk, is noninvasive, … |
JARRED YOUNGER; | 2023-12-31 |
| 126 | Treatment of CFS and Fibromyalgia With HRG 80 Red Ginseng PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Will a unique form of ginseng be clinically helpful in those with chronic fatigue syndrome and fibromyalgia? |
JACOB TEITELBAUM; | 2021-04-30 |
| 127 | Mechanistic Assessment of N-Acetylcysteine As An Antioxidant Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Through Dose Response and Treatment Target Engagement PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) is an unexplained multisymptom/multisystem disorder for which there are currently no validated treatments. The present exploratory clinical trial aims to advance our understand of the mechanisms of in situ GSH synthesis control through assessment of the response of brain GSH and plasma markers of oxidative stress to different doses of NAC in comparison to placebo, as a potential treatment for ME/CFS that would provide neuroprotection against oxidative stress by restoring cortical GSH reserves. If successful, … |
DIKOMA C. SHUNGU; | 2025-03-20 |
| 128 | The Influence of Beliefs (Fear of Movement, Pain-related Fear, Self-efficacy, and Pain Acceptance) on The Prognosis of Chronic Musculoskeletal Pain: A Prospective Cohort Study. Study Protocol PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic musculoskeletal pain (CMP) is highly prevalent, disabling, and with high socio-economic costs, with many negative effects on quality of life. CMP affects the ability to perform work, social, recreational and domestic tasks, changing the mood and concentration of this population. Despite the worldwide prevalence and socioeconomic burden of CMP, a clear understanding of its etiology and pathogenesis remains elusive. Aims: (i) to analyze the possible level of association between pain-related fear, fear of movement, self-efficacy, and pain acceptance with pain intensity and disability at the start of the study and prospectively evaluate its predictive function; … |
ALEJANDRO LUQUE-SUAREZ; | 2020-12-01 |
| 129 | The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic fatigue syndrome is a common problem in society. The treatment of this problem is limited. Acupressure is a treatment method that has become widespread and promising in recent years. For this purpose, the effect of acupressure treatment on chronic fatigue syndrome was investigated. |
ISTANBUL MEDIPOL UNIVERSITY HOSPITAL | 2021-02-01 |
| 130 | Effectiveness of Virtual Multicomponent Treatment for Chronic Fatigue Syndrome: VIRTUAL SFCAMINA STUDY PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this study is to analyse the effectiveness of the VIRTUAL SFCAMINA multicomponent treatment program as coadjuvant of treatmentas- usual (TAU) compared to TAU alone. In this Randomized Controlled Trial (RCT), in addition to evaluating the clinical effects of VIRTUAL SFCAMINA treatment in the short- and long term. |
MAYTE SERRAT; | 2022-01-21 |
| 131 | Effect of Probiotic Food Supplement GutMagnific™ in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known As Post-viral Fatigue Syndrome, and Comorbid Gastrointestinal Complications PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a neurological disease. Currently there is no effective treatment for ME/CFS due to unclear etiology of the disease. The aim of this randomized double-blind placebo-control clinical trial is to study the efficacy of the probiotic food supplement GutMagnific™ in ME/CFS and comorbid gastrointestinal complications. The outcome of the study will be assessed based on the data from different self-reporting questionnaires and intestinal microbial flora analysis. |
PER JULIN; | 2021-06-30 |
| 132 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess The Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Quality of Life After The Administration of ImmunoVita® in Chronic Fatigue Syndrome Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS / MS) is a medical entity characterized mainly by debilitating and prolonged fatigue lasting more than 6 months, post-exertion fatigue (physical and / or mental), non-sleep restorative, cognitive impairment and orthostatic intolerance with prolonged recovery that is not relieved by rest. Currently, the etiopathogenic mechanisms of the disease are not known, although mitochondrial dysfunction with bioenergetic immuno-metabolism alterations, oxidative stress, and immuno-inflammatory response stands out. At present, there is no diagnostic test, nor effective treatment in the disease. ImmunoVita, is a food supplement composed of the latest yeast beta-glucans, … |
JOSÉ ALEGRE; | 2021-12-31 |
| 133 | A Pilot Study for Continuous Monitoring of Physical Activity Using Activity Armbands for 6 Months: Assessment of Feasibility and Comparison to Self-reported Questionnaires PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators will assess the feasibility of activity monitoring armbands for continuous measurement of physical activity level in ME/CFS patients, during 6 months follow-up. The main purpose is to assess if continuous measurement of activity level may be incorporated in outcome measures in future clinical interventional trials. |
HAUKELAND UNIVERSITY HOSPITAL | 2020-11-20 |
| 134 | A Non-Interventional Pilot Study to Explore The Role of Gut Flora in Eczema Related Papers Related Patents Related Grants Related Experts Highlight: This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding eczema. |
SABINE HAZAN; | 2025-06-05 |
| 135 | A Non-Interventional Pilot Study to Explore The Role of Gut Flora in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Related Papers Related Patents Related Grants Related Experts Highlight: This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). |
SABINE HAZAN; | 2025-06-05 |
| 136 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Myalgic encephalomyelitis/Chronic fatigue syndrome (ME/CFS), otherwise known as Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME), is an under-recognized disorder whose cause is not yet understood. Suggested theories behind the pathophysiology of this condition include autoimmune causes, an inciting viral illness, and a dysfunctional autonomic nervous system caused by a small fiber polyneuropathy. Symptoms include fatigue, cognitive impairments, gastrointestinal changes, exertional dyspnea, … |
DAVID SYSTROM; | 2021-12-20 |
| 137 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of The Patients With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Gut microbiota of 1) patients with chronic fatigue syndrome and 2) their healthy family members are analyzed. Up to 40 patients with chronic fatigue syndrome are randomized to receive either 1) a faecal transplant from a healthty donor or 2) their own feces via colonoscopy. Patient’s health related quality and ability to work are assessed (baseline, 1 and 6 months after the procedure) |
TAPANI SALONEN; | 2022-03-31 |
| 138 | CBT Based Group Therapy for Patients With Chronic Fatigue Syndrome (CFS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic fatigue syndrome is a severe medical condition. It is characterized by long term fatique and other persisted symptoms, such as a cognitive disabilities and orthostatic intolerance. Symptoms limit a persons ability to carry out ordinary daily activities. In ICD- 10, disease is known as G93.3, postviral fatigue syndrome. The purpose of this research (doctoral study) is to produce a psychological, cognitive behavioral therapy (CBT) based group intervention for CFS- … |
JOINT AUTHORITY FOR PÄIJÄT HÄME SOCIAL AND HEALTH CARE | 2024-12-31 |
| 139 | A Randomized, Double-blind, Comparator-controlled, Cross-over Study to Investigate The Safety and Efficacy of RiaGev™ in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This current randomized, double-blind, comparator-controlled, cross over study investigates the efficacy and safety of RiaGev™ via evaluation of NAD+, ATP, glucose, insulin, glutathione, and cortisol levels in healthy adults of ages 36-65. |
TRISHA SHAMP; | 2020-11-30 |
| 140 | Autonomic Neuropathy and Its Pathophysiology in Autoimmune Autonomic Neuropathies, Postural Orthostatic Tachycardia Syndrome and Ehlers Danlos Syndromes: Peripheral Autonomic Small Fiber Neuropathy or Central Autonomic Failure? Validation of The Malmö POTS Score and A Better Diagnosis of POTS in Patientes With Autnomic Failure (VaGeMAPS-3-step-Diag) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care. |
ANDREA MAIER; | 2025-02-04 |
| 141 | Hypermobility and Obstructions in The Craniocervical Region Among Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A retrospective study on clinical and radiological findings in ME/CFS |
BRAGEE CLINICS | 2019-09-30 |
| 142 | Hydrogen Water As A Treatment for Chronic Fatigue Syndrome: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed placebo-controlled pilot study will examine hydrogen water as a treatment for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). 25 subjects who meet strict criteria for ME/CFS will be recruited. The 30 day trial will involve subjects ingesting 1-5 8 oz. glasses of hydrogen-dissolved water per day. The placebo condition will involve the same daily ingestion schedule but with an inert placebo pill instead of the active hydrogen treatment pill. The proposed study is intended to establish feasibility of the clinical protocol and examine potential treatment effects of hydrogen water which may include symptom reduction and possibly improved functioning. If feasibility and apparent treatment effects are confirmed, a large clinical trial will be proposed for submission to NIH. In addition to potential therapeutic properties, H2 water is portable, easily administered and safe to ingest. Self-report assessments for ME/CFS symptoms, fatigue, autonomic symptoms, physical function, anxiety, and depression will be done in the week before and the week after the 30 day trial. In addition, 7-day home-based objective assessments of heart rate variability (a measure of parasympathetic function) and accelerometry (a physical activity assessment) will be scheduled before and after the intervention period. |
FRED FRIEDBERG; | 2021-06-01 |
| 143 | Molecular Response to Custom Manual Physiotherapy Treatment of Fibromyalgia & Chronic Fatigue Syndrome (CFS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Fibromyalgia (FM)and Chronic Fatigue Syndrome (CFS) are complex diseases often presenting overlapping symptomatology. Manual therapy (MT) protocols report benefits for pain treatment of FM, but the underlying mechanisms for patient improvement remain unknown. The main goal of this study is to assess the molecular changes associating to mechanical and additional MT triggers, possibly involved in patient symptom improvement. |
MARÍA GARCÍA ESCUDERO; | 2020-03-10 |
| 144 | Assessment of Exercise Response in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the correlation between the 6-min walking test (6MWT) with gases measurement, and the peak cardiopulmonary exercise testing (CPET) using incremental cycling with gases and workload measurement, in order to determine if the 6MWT detects impairment in exercise tolerance and if it avoids the post-exertional malaise that the peak CPET causes on decreasing levels of physical activity, in participants affected by chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME). Physical activity level at baseline (usual activity, the parcipant will not be given any directions) will be recorded during 7 days, 24 hours/day. Afterwards, … |
SUSANA GARCÍA JUEZ; | 2025-03-10 |
| 145 | Randomized Controlled Trial Comparing Two Different Bladder Instillation Treatments for Interstitial Cystitis/Bladder Pain Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a condition that results in long-term bladder and pelvic pain. IC/BPS affects women more often than men. How the disorder develops is not completely known. Bladder instillation is a commonly used treatment in which a mixture of different ingredients are passed into the bladder to help IC/BPS symptoms. There is room to learn more about bladder instillations and which ingredients in them work best. The purpose of this study is to compare the effectiveness of a bladder instillation that contains a steroid (triamcinolone acetonide) to a bladder instillation that does not contain a steroid to treat IC/BPS in women. The study hypothesis is that women with IC/BPS treated with bladder instillations that contain a steroid will have improved outcomes compared to women treated with bladder instillations that do not contain a steroid. |
OLIVIA CARDENAS-TROWERS; | 2020-10-23 |
| 146 | Evaluation of The Neuromedulatory Effect of Transcranial Direct Current Electrical Stimulation (tDCS) in Carpal Tunnel Syndrome (CTS): A Double Blinded Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a double blinded randomized clinical trial to study the neuromodulatory effect of tDCS in patients with CTS, the study subject will be randomly into two groups; active and sham group , the active group will receive five sessions of active TDCS over the M1 while the Sham group will receive sham tDCS in which the device will be turned off after 30 seconds. The patient will be assessed by VAS score, Boston carpal tunnel questionnaire , central sensetization inventory , pressure pain threshold, sensory and pain threshold for electerical stimulation before , … |
GEHAD SWILAM ABDELMONEM SWILAM; | 2020-03-01 |
| 147 | Shanghai University of Traditional Chinese Medicine PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is to disclose the mechanism of characteristic Tao yin exercises regulate Chronic Fatigue Syndromes based on Brain-Gut Axis.Explore the clinical manifestation of Chronic Fatigue Syndromes, changes of neurotransmitter and central brain function. Then provide some new methods of treating Chronic Fatigue Syndromes. |
SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE | 2021-12-01 |
| 148 | Study of The Pathogenic Mechanisms of Metabolic Syndrome at The Background of Genetically Determined Insulin Resistance in Childhood Cancer Survivors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The research is devoted to studying the features of the metabolic syndrome in cancer survivors in childhood is supposed to answer the following questions: – How can metabolic syndrome be diagnosed in the Russian population of survivors of acute lymphoblastic leukemia and non-Hodgkin’s lymphomas? – What are the features of the clinical symptoms of metabolic syndrome in this category of patients? – Which genetic mutations are found in cancer survivors of patients with metabolic syndrome; … |
FEDERAL RESEARCH INSTITUTE OF PEDIATRIC HEMATOLOGY ONCOLOGY AND IMMUNOLOGY | 2022-12-20 |
| 149 | A Randomized-controlled Clinical Trial of Hypnosis Versus Open Label Placebo for Chronic Neuropathic Pain With An Investigation of Neuro-cognitive Dysfunctions As Maintaining Factors and Therapeutic Targets PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of the study is to a) assess the presence of a maladaptive stress response, a decreased pain modulation and any cognitive impairment in patients with chronic neuropathic pain in comparison to healthy controls. and b) evaluate the efficacy of a treatment of hypnosis and of an open label placebo on these neuro-cognitive factors and on clinical pain. This will be done through a) a prospective observational comparative study of patients (base line measures) with Healthy Controls (HC) and b) an Open label; randomised, hypnosis vs. open label placebo (OLP) vs. treatment as usual control design; … |
CHANTAL BERNA; | 2023-12-01 |
| 150 | Probing Metabolism, Circulating Inflammatory Molecules, Extracellular Vesicles and Immune Dysregulation in Individual Immune Cells in ME/CFS PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to collect and identify key outcome measures or disease parameters in ME/CFS that are altered during elevated symptoms relative to baseline by gathering information before and after symptom provocation using a two-day cardiopulmonary exercise test. |
ITHACA COLLEGE | 2022-08-31 |
| 151 | Pilot Phase 1/2, Open-Label, Clinical Trial to Investigate CT38 in The Treatment of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study seeks to investigate the safety, tolerability and efficacy of CT38, an experimental peptide administered by subcutaneous infusion, in the treatment of ME/CFS patients. |
LUCINDA BATEMAN; | 2019-04-30 |
| 152 | Developing An Activity Pacing Framework for The Management of Chronic Pain/Fatigue. Stage III: Feasibility and Acceptability Studies PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study explores whether it is feasible to use a newly developed activity pacing framework to standardise how activity pacing is instructed by healthcare professionals in rehabilitation programmes for patients with chronic pain/fatigue. |
DEBORAH ANTCLIFF; | 2019-12-31 |
| 153 | New MRT Imaging Biomarkers and Treatment With Kinetic Oscillatory Stimulation (KOS) in Nasal Cavity for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Placebo controlled trial study of efficacy of Kinetic Oscillation Stimulation (KOS) in nasal cavity will be conducted in patients with myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The outcome of the treatment will be assessed with clinical evaluation of patients, cognitive tests, structural and functional MRI of the brain. |
TIE-QIANG LI; | 2020-06-15 |
| 154 | Defining Autoimmune Aspects of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates whether there is an immune response directed against gut microbes or food and parts of the body in severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients. |
SIMON CARDING; | 2020-09-30 |
| 155 | Central Sensitization in Vitamin D Deficiency and Effect of Vitamin D Replacement on Cutaneous Silent Period PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate the presence of central sensitization in vitamin D deficiency and its effect on cutaneous silent period, pain, and quality of life. The secondary purpose of the study is to investigate whether a change in cutaneous silent period parameters, pain severity and neuropathic sensitization and quality of life after vitamin D replacement. |
OZGE KENIS COSKUN; | 2018-12-19 |
| 156 | Role of The NLRP3 Inflammasome Activation, Mitochondrial Biogenesis, and Immunoinflammatory Response After Oral Coenzyme Q10 Plus Selenium Supplementation in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In recent years, it has been suggested that nutritional deficiencies may be of causal relevance in individuals with ME/CFS. These include deficiencies of vitamins and trace elements. It is likely that the observed nutritional deficiencies contribute to the core symptoms of the disease. Coenzyme Q10 (CoQ10) has been studied as an alternative and complementary therapy in ME/CFS for fatigue, pain, tiredness, neurocognitive impairment, and sleep problems. This demonstrates how alterations in energy metabolism, mitochondrial dysfunction, oxidative stress, imbalance of the immune-inflammatory response, and activation of the NLRP3 inflammasome are likely consequences of low levels of CoQ10 and selenium, … |
JOSÉ ALEGRE; | 2018-11-30 |
| 157 | Sex Differences in Exercise-related Post-exertional Malaise in ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This pilot study is intended to identify sex differences in myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) during recovery from brief but high effort exercise tests. It is expected that women with ME/CFS as compared to males with ME/CFS will show slower recovery from exercise with respect to heart rate and blood pressure, physical functioning, and symptom severity. Also females with ME/CFS as compared to males with ME/CFS will show greater negative impacts on heart rate, blood pressure, … |
FRED FRIEDBERG; | 2018-10-01 |
| 158 | Effect of Coenzyme Q10 Plus NADH Supplementation on The Changes in Fatigue Perception, Sleep Disturbances, Autonomic Function and Health-related Quality of Life in CFS/ME – A Randomized, Placebo-controlled, Double-blind Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main aim of the study is to examine the effect of oral CoQ10 plus NADH (Reconnect®) supplementation twice daily for 8-weeks on the changes in fatigue perception, sleep disturbances, autonomic dysfunction and HRQoL assessed by patient-reported outcome measures in CFS/ME. |
JOSE ALEGRE; | 2021-09-01 |
| 159 | Development and Clinimetric Properties of The Dutch Pediatric Neurophysiology of Pain Questionnaire in Healthy Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The scientific objective of this research implies developing and examining the clinimetric properties of the Dutch Pediatric Neurophysiology of Pain Questionnaire (PedNPQ) in healthy children. A total study sample of 60 healthy children (30 from 2nd and 3rd primary school) will be included to measure test-retest reliability of the Pediatric Neurophysiology of Pain Questionnaire (PedNPQ). Children will be asked to fill in the questionnaire twice, with a time interval of 48 hours (assessment T0 and T1). In order to assess concurrent validity of the PedNPQ, … |
ROSELIEN PAS; | 2018-09-22 |
| 160 | Multicenter Study, Randomized, Parallel Group Controlled, Testing The Effectiveness of A Behavioral Cognitive Therapy (BCT) Vs Usual Local Practice on The Fatigue of Patients With Relapsing Remittent Multiple Sclerosis (RRMS) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Multiple sclerosis (MS) is a chronic inflammatory disease that leads to demyelination of the central nervous system. Fatigue is one of the most frequent and most disabling symptoms of MS. Up to 86% of individuals with MS experience fatigue at any one time; 65% consider it to be one of their three most troubling symptoms. Fatigue may limit or prevent participation in dayly activities and reduce psychological well-being (1, 2). Pharmacological and non-pharmacological treatments are available for MS-related fatigue, but evidence on effectiveness is mostly inconclusive or non-existent. The psychological approaches of fatigue management are interesting. To date, … |
OLIVIER HEINZLEF; | 2020-10-15 |
| 161 | Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic pain and fatigue are characterized by peripheral and central mechanisms including low pain thresholds, temporal summation, peripheral and central sensitization. This application will focus on central factors of chronic pain and fatigue. Functional brain imaging will be used to characterized brain and spinal cord abnormalities that contribute to the mechanisms of these disorders. |
ROLAND STAUD; | 2024-12-13 |
| 162 | The Possible Beneficial Effects of Mindfulness-Based Cognitive Therapy (MBCT) in Fatigued Adult Patients With Inflammatory Bowel Disease (IBD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The current study aims to investigate the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) for reducing fatigue in Inflammatory Bowel Disease patients in remission. |
MAYA SCHROEVERS; | 2019-11-09 |
| 163 | Noradrenergic and Stress-Related Etiologies of Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to measure sympathetic nervous system function and stress responses in patients with clinically documented and self-reported chronic fatigue that is worsened by stress, compared to healthy controls. Baseline norepinephrine (NE) levels and stress-induced NE levels in patients who fulfill criteria for Chronic Fatigue Syndrome (CFS) and who self-identify with stress induced worsening fatigue, will be compared to data from normal individuals pre and post-stress. |
GORDON BERNARD; | 2018-02-23 |
| 164 | High-tech Acupuncture for Treatment of Chronic Fatigue Syndrome – A Sino-Austrian Cooperation Randomized Controlled Trial(RCT) on Heart Rate Variability PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. To study the relationship between Chronic Fatigue Syndrome (CFS) and heart rate (HR) and its variability (HRV). 2. To compare the curative effects and the HR/HRV indices between applicationa of different acupoints as well as different treatments (acupuncture and moxibustion). |
HUBEI PROVINCIAL COLLABORATIVE INNOVATION CENTER OF PREVENTIVE TREATMENT BY ACUPUNCTURE AND MOXIBUST | 2018-07-01 |
| 165 | Thunder-Fire Moxibustion Therapy for Chronic Fatigue Syndrome on Shenque Acupoint: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic fatigue syndrome is a group of syndrome and is prevalent in adult. Thunder-fire moxibustion is a commentary therapy belonged to acupuncture therapy. To evaluate the effect and safety of thunder-fire moxibustion therapy for chronic fatigue syndrome, we apply a randomized controlled trial by recruiting chronic fatigue syndrome patient as subject, applying thunder-fire moxibustion on shenque acupoint contrasted to common moxa-stick moxibustion, taking fatigue rating scale score, the content of CD3+、CD4+、CD8+、CD4+/CD8+ as evaluation indexes. The treatment time is 20-30 minutes per session, 3-4 times a week, there are totally 15 sessions. |
HAILI LUO; | 2017-02-01 |
| 166 | Fatigue in Sarcoidosis – A Feasibility Study Investigating The Treatment of Fatigue in Stable Sarcoidosis Patients Using Methylphenidate PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a small randomised-controlled trial (RCT) using methylphenidate as a treatment for clinically-significant fatigue in sarcoidosis patients with stable disease. The primary outcomes are feasibility, aimed at determining factors that will influence the design a future, larger RCT, which will be powered to look at clinical efficacy of the intervention. |
ANDREW M WILSON; | 2018-07-01 |
| 167 | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Post-Infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (PI-ME/CFS) refers to long-lasting and disabling fatigue or malaise, inability to recover after exercise, and physical and emotional discomfort that may occur after a person has an infection. Researchers want to learn more about its causes. Objective: To learn more about PI-ME/CFS. Eligibility: Adults ages 18-60 years who have finished at least 7th grade education and either: have ME/CFS that started after an infection OR had Lyme disease, were treated, … |
AVINDRA NATH; | 2022-01-11 |
| 168 | ME/CFS: Activity Patterns and Autonomic Dysfunction PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to identify daily activity patterns, negative life events and autonomic abnormalities that may be related to non-improvement in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). For both naturalistic studies and behavioral intervention trials, roughly 50% of patients report worsening or unchanged illness. The proposed four year study would be the first to look at the relation between illness non-improvement, patient activities at home and autonomic function. Our long-range goal is to identify physiological signals and activity patterns that predict non-improvement and relapse and develop a self-management program that prescribes improvement-linked behaviors and discourages non-improvement activities. |
FRED FRIEDBERG; | 2020-05-01 |
| 169 | A Clinical Study About Improvement of Chronic Fatigue After Taking Red Ginseng PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to verify the efficacy of taking red ginseng for chronic fatigue patient. |
EUN JUNG KIM; | 2017-06-01 |
| 170 | MicroRNAs As Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome (CFS) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: MicroRNAs were shown to play an important role in regulating pain-processing in a wide range of experimental models and clinical pain disorders. Thus, the aim of the present study is to evaluate a set of Micro-RNAs as diagnostic biomarkers of pain intensity in adolescents with chronic fatigue syndrome (CFS) and to correlate with inflammatory markers and pain related comorbidities. |
SAMI GABR; | 2017-04-30 |
| 171 | Reducing Orthostatic Intolerance With Oral Rehydration in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can’t tolerate prolonged standing. OI in ME/CFS is often accompanied by either postural tachycardia syndrome (POTS) in which standing results in an excessive heart rate, and neurally mediated hypotension (NMH) in which standing causes a fall in blood pressure and fainting. Intravenous fluids can alleviate these symptoms, but is difficult to administer; oral fluids fail to provide the same benefit. We would therefore like to test the effectiveness of an oral rehydration solution (ORS, … |
MARVIN S. MEDOW; | 2021-12-01 |
| 172 | An Unicentric, Double-blind, Placebo Controlled, Phase IV Clinical Trial of Oral Melatonin Plus Zinc to Evaluate Relieving Self-reported Fatigue in CFS/ME PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the effects of oral melatonin plus zinc supplementation in relieving self-reported fatigue in CFS/ME |
JOSÉ ALEGRE; | 2017-09-01 |
| 173 | The Effects of Medium-term Creatine Supplementation in Adults With Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the effectiveness of medium-term supplementation with creatine to improve clinical outcomes in well-defined adult CFS population. Half of the participants will receive creatine while the other half will receive placebo. |
SERGEJ M. OSTOJIC; | 2025-05-23 |
| 174 | The Immune Effects of Low-dose Naltrexone in People With Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this study is to test if naltrexone, when taken in low doses, has an anti-inflammatory effect that may be associated with positive clinical outcomes in people with chronic fatigue syndrome (CFS). In part, the present study, is a continuation of prior work in which we showed that chronic fatigue symptoms are associated with immune activity, and that low-dose naltrexone might exert anti-inflammatory effects in fibromyalgia, which is thought to share some pathophysiological and clinical characteristics with CFS. |
JARRED YOUNGER; | 2022-08-25 |
| 175 | Restauration of EBV Control in SLE Phase 1-2 Trial Evaluating Adoptive Transfer of Autologous EBV- Specific Cytotoxic T Lymphocytes in SLE Treatment Related Papers Related Patents Related Grants Related Experts Highlight: EBV has been implicated in pathogeny of SLE with increase in EBV sero-prevalence, defective control in EBV infection and altered both B and T immune responses to this virus The main objective of this pilot proof-of-concept (POC) study is to evaluate safety and efficacy of autologous EBV specific CTL adoptive transfer in adult patients with serologically active SLE |
NANTES UNIVERSITY HOSPITAL | 2021-07-01 |
| 176 | Mental Training for Chronic Fatigue Syndrome (CFS/ME) Following EBV Infection in Adolescents: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The general aim of this study is to investigate the effect of an individually tailored mental training program in adolescents developing chronic fatigue syndrome (CFS) after an acute Epstein Barr-virus (EBV) infection. Endpoints include physical activity (primary endpoint), symptoms (fatigue, pain, insomnia), cognitive function (executive functions) and markers of disease mechanisms (autonomic, endocrine, and immune responses). |
VEGARD WYLLER; | 2018-10-01 |
| 177 | The PRINCE Secondary Study: Persistent Physical Symptoms Reduction Intervention: A System Change and Evaluation in Secondary Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Brief Summary: Persistent Physical Symptoms (PPS), also known as medically unexplained symptoms (MUS) is a term used to describe a range of persistent bodily symptoms for which the exact cause is unclear. Between 20 and 40% of patients in primary care, and about 50% in secondary care experience PPS. Not only are PPS common, but the overlap across different patient groups may indicate that these phenomena are transdiagnostic. PPS are associated with profound disability and high health care costs, … |
TRUDIE CHALDER; | 2019-01-01 |
| 178 | A 60-Day Clinical Study to Evaluate Nutrilite Ginko Biloba Cistanche Tablets in Relieving The Symptoms of Chronic Fatigue Syndromes Compared to Negative Control PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy of Nutrilite® ginkgo biloba cistanche tablets in relieving the symptoms of chronic fatigue syndrome(CFS), the investigators randomly recruit189 subjects with CFS, aged 35-60 yrs. The relief of fatigue and improvement of sexual function are evaluated by World Health Organization Quality Of Life Brief (WHOQoL-Bref), Sexual Life Quality Questionnaire (SLQQ), chronic fatigue syndrome, symptoms of self-assessment at the baseline and the end of intervention. Subjects also underwent a blood test measuring the concentration of biochemical indicators. Cistanche is mainly used to strengthen the renal function, nourish essence and blood in the treatment of lumbar debility, impotence, … |
SHUGUANG LI; | 2015-12-01 |
| 179 | Persistent Physical Symptoms Reduction Intervention: A Systems Change and Evaluation (PRINCE) – Integrated GP Care for Persistent Physical Symptoms: A Feasibility & Cluster Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: PRINCE primary is cluster randomised waiting list controlled trial to evaluate the feasibility of an integrated approach to care in general practice for adults with persistent physical symptoms (PPS). PPS is defined as physical symptoms with no obvious underlying organic. 240 patients with PPS recruited from 8-12 GP practices in London will be randomised to the integrated care approach plus treatment as usual (TAU) or TAU alone. The integrated GP approach consists of providing GPs with a short cognitive behaviour therapy (CBT) skills training, ongoing supervision, as well as written and audio-visual materials/guidelines. In addition, … |
TRUDIE CHADER; | 2018-01-01 |
| 180 | Meriva for Treatment-induced Inflammation and Fatigue in Women With Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of the investigation is to determine if curcumin reduces NF-kB DNA binding and ultimately its downstream mediator IL-6 in patients receiving XRT for their breast cancer after having completed chemotherapy. Patients who have received prior chemotherapy will be eligible, because we have found that this enriched population is at particular risk for exhibiting increased NF-kB DNA binding and IL-6 following XRT. |
ANDREW H MILLER; | 2018-07-27 |
| 181 | Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS). Part A: An Open Label Phase-II Study With Six Intravenous Cyclophosphamide Infusions Four Weeks Apart, and Follow-up for 12 Months PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Significant clinical improvements of ME/CFS symptoms were observed in two patients with long-standing ME/CFS who received adjuvant chemotherapy including cyclophosphamide for breast cancer, also in one ME/CFS patient who received chemotherapy including iphosphamide for Hodgkin lymphoma. Three pilot ME/CFS patients were thereafter treated with six intravenous infusions four weeks apart, in two of these with a significant clinical response. The hypothesis is that a subset of ME/CFS patients have an activated immune system, and that ME/CFS symptoms may be alleviated by treatment with cyclophosphamide as intravenous pulse infusions four weeks apart, … |
MELLA OLAV; | 2019-12-06 |
| 182 | Acceptance and Commitment Group Therapy for Adolescents With A Range of Functional Somatic Syndromes: Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: An increasing number of adolescents report recurrent functional somatic symptoms. Some experience persistent symptoms and may receive functional somatic syndromes (FSS) diagnoses (i.e. symptoms not attributable to any known conventionally defined physical disease), characterised by severe disability and reduced quality of life. The aim of this study is to: 1. Develop an Acceptance and Commitment Therapy (ACT)-based group intervention for adolescents with severe FSS (conceptualized as Bodily Distress Syndrome (BDS), see detailed description). 2. Examine the efficacy of group based ACT in adolescents (aged 15-19 years) with severe FSS. The ACT-based treatment, … |
CHARLOTTE U RASK; | 2019-11-21 |
| 183 | Phase IIa Open Label Study to Evaluate The Safety, Tolerability, and Efficacy of KPAX 002 (Methylphenidate Hydrochloride + K-PAX Synergy) As A Treatment for Gulf War Illness in Patients Meeting The Kansas Case Definition PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Gulf War Synergy Trial will evaluate the safety and efficacy of a currently available medication, methylphenidate (Ritalin®), combined with a GWI Nutrient Formula (K-PAX Synergy) to treat Gulf War Illness (GWI). |
MARK HOLODNIY; | 2016-05-01 |
| 184 | Mindfulness-Based Therapy for Interstitial Cystitis/Bladder Pain Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood disease with unreliable treatments. Although it is not known what causes it for certain, we do know that life stressors may make the disease worse or cause flares. Mindfulness Based Stress Reduction (MBSR) is an 8 week class focused on meditation and other techniques that the investigators think may be helpful to people with IC/BPS. This trial will assign participants to an MBSR class or usual care for their IC/BPS to see if the MBSR class would be helpful for their disease. |
GREGORY KANTER; | 2015-06-01 |
| 185 | Testing The Effects of Methylphenidate on Cognitive Fatigue in Multiple Sclerosis: A Double-blind, Placebo-controlled, Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Up to 95% of individuals with Multiple Sclerosis report experiencing cognitive fatigue, characterized by a lack of energy, feelings of exhaustion, an the perception that one is unable to partake in daily activities. The goal of this project is to test whether methylphenidate (MP), a well-known psychostimulant, … |
SILVANA COSTA; | 2025-09-02 |
| 186 | Biopsychological Intervention in Chronic Fatigue Syndrome – A Pilot Study Related Papers Related Patents Related Grants Related Experts Highlight: This is a pilot study of a biopsychological intervention program for adolescent chronic fatigue syndrome. The program is related to cognitive behavioral therapy, which has been proven beneficial in this disorders, but includes other mental techniques, such as emotional control and metacognitive elaboration. The aim of this pilot study is to explore a) patients’ experiences and b) possible positive effects on symptoms. We hypothesise that the intervention will be regarded feasible by the patients, and that fatigue score will improve during the intervention period. |
OSLO UNIVERSITY HOSPITAL | 2015-01-01 |
| 187 | B-lymphocyte Depletion Using The Monoclonal Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME). A Multicentre, Randomized, Double-blind and Placebo Controlled Phase-III Study With Rituximab Induction and Maintenance Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The hypothesis is that a subgroup of patients with Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME) have a chronically activated immune system and may benefit from B-lymphocyte treatment using the monoclonal anti-CD20 antibody rituximab with induction and maintenance treatment. |
OLAV MELLA; | 2017-11-01 |
| 188 | Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic fatigue syndrome (CFS) is a debilitating condition of unknown etiology. Recent studies have shown that CFS is associated with impaired cellular energetics and low levels of phosphocreatine. Since guanidinoacetic acid (GAA) acts as a highly bioavailable precursor of creatine it may provide an ideal dietary supplement to facilitate treatment and perhaps prevention of CFS. The overall hypothesis to be evaluated is that medium-term supplementation with GAA will improve clinical outcomes in well-defined adult CFS patients via augmented provision of creatine. Specific aims: (1) To determine the effects of GAA on CFS symptomatology using a fatigue severity inventory, … |
SERGEJ M. OSTOJIC; | 2015-07-01 |
| 189 | A Feasibility Study of A Brief Psychological Intervention for Post-stroke Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is a leading cause of adult disability in the community. Fatigue affects about a third of stroke survivors. It results in difficulty taking part in everyday activities, and increases risk of hospitalization and death after stroke. Despite of its high prevalence and distressing consequences, there is no effective treatment. Psychological interventions have improved fatigue in patients with other conditions such as multiple sclerosis. These interventions primarily target patients’ beliefs about overcoming fatigue and their physical activities in daily life. Also studies indicated that post-stroke fatigue is associated with mood. Based on this knowledge, … |
SIMIAO WU; | 2015-04-01 |
| 190 | Cytokine Inhibition in Chronic Fatigue Syndrome Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Rationale: Chronic fatigue syndrome (CFS) is a medically unexplained syndrome for which no somatic or pharmacological treatment has been proven effective. Dysfunction of the cytokine network has been suspected to play a role in the pathophysiology of CFS. Although derangements of the cytokine network in CFS are controversial, a major problem is that many studies did not use adequate controls. In addition, all studies have been performed on peripheral venous blood of the patients. As cytokines mainly act in the tissues, e.g., the brain, … |
JOS VAN DER MEER; | 2016-05-01 |
| 191 | Cardiopulmonary Exercise Testing As A Diagnostic Tool and A Quantitative Measure of Post-exertional Malaise in Myalgic Encephalopathy/Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Circumstantial evidence suggests that patients diagnosed with myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) perform worse on day 2 in a 2-day consecutive cardiopulmonary exercise test (CPET). The aim of this study is to examine if CPET can distinguish between ME/CFS patients and healthy controls. |
PER OLE IVERSEN; | 2020-11-01 |
| 192 | Psychological Wellbeing in Adults With Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objectives: Chronic Fatigue Syndrome (CFS) is a medically unexplained condition characterized by severe and disabling fatigue. To date much research has focused on finding out whether CFS is caused by mainly physical or psychological factors. Perhaps as a result of this, few studies have examined the relationship between CFS and quality of life, in particular, more positive aspects of mental health, such as an individual’s sense of purpose, autonomy and close relationships. This study will address these limitations by examining Ryff’s (1989) six domains of psychological well-being (PWB), and other aspects of well-being including positive emotions, … |
HANNAH JACKSON; | 2015-01-01 |
| 193 | The Efficacy of A Mindfulness Based Intervention for Depressive Symptoms in Patients With Multiple Sclerosis and Their Caregivers. A Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Multiple Sclerosis has a great impact on psychological functioning of patients and can be associated with various psychological disorders and symptoms. The most prevalent one is depression, which ranges from 15% to 47%. Mindfulness Based Intervention (MBI) is a relatively brief and cost-effective program that has been studied in patients with several diseases. Aims. To evaluate the efficacy of a group-based MBI on depressive symptoms, … |
LUCA OSTACOLI; | 2017-05-01 |
| 194 | Slow-wave Sleep and Daytime Functioning in Chronic Fatigue Syndrome: Effects of Sodium Oxybate PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators wish to investigate whether enhancement of SWS, which is seen after a drug called sodium oxybate, reduces the impact of sleep disruption in CFS on daytime function, specifically sleepiness and mental performance. This is a safe and well-tolerated drug that is licensed for excessive daytime sleepiness (EDS) and cataplexy associated with narcolepsy. The investigators will study 12 patients diagnosed with CFS using international diagnostic guidelines. The investigators will record overnight sleep with EEG (brainwave) measurement on the 1st and 4th nights of a 4 night period during which sodium oxybate and placebo will be taken nightly, … |
DAVID NUTT; | 2015-08-01 |
| 195 | Effect of Neuroscience Education on Subjects With Chronic Knee Pain Related to Osteoarthritis : A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great disability and significant healthcare costs. Substantial scientific evidence indicates a role for central sensitization in OA pain. Reconceptualization of pain through Neuroscience Education (NE) is an intervention that has already been used successfully in some chronic musculoskeletal pain conditions characterized by alteration on CNS pain processing or central sensitization (i.e. chronic low back pain, chronic fatigue syndrome, widespread pain and chronic whiplash associate disorders).There is compelling evidence that NE have a positive effect on pain, disability, catastrophization and physical performance for chronic musculoskeletal pain disorders, … |
ENRIQUE LLUCH GIRBÉS; | 2015-12-01 |
| 196 | Randomized, Double-Blind, Placebo Controlled Study to Evaluate The Safety, Tolerability, and Efficacy of Methylphenidate Hydrochloride As A Treatment for Chronic Fatigue Syndrome in Patients Taking A CFS-Specific Nutrient Formula PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The Synergy Trial will evaluate the safety and efficacy of a currently available medication (methylphenidate hydrochloride) combined with a CFS-specific dietary supplement (CFS Nutrient Formula) to treat Chronic Fatigue Syndrome (CFS). |
JOSE MONTOYA; | 2014-12-01 |
| 197 | Exertional Exhaustion in Chronic Fatigue Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Post-exertional malaise was modeled by having Chronic Fatigue Syndrome (CFS) and sedentary control subjects perform submaximal exercise on 2 consecutive days with objective changes in brain function measured by magnetic resonance imaging (MRI) during cognitive tests before and after the 2 exercise sessions. |
JAMES BARANIUK; | 2018-07-31 |
| 198 | Use of A Monitor in ME/CFS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The use of an activity monitor to determine increase or decrease of activity in patients suffering from chronic fatigue syndrome. |
DEREK ENLANDER; | 2013-12-01 |
| 199 | Observational Research on Use of Immunoprop Supplement in Chronic Fatigue Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Observational study regarding the use of supplements in chronic fatigue syndrome patients |
DEREK ENLANDER; | 2013-12-01 |
| 200 | The Effect of Sodium Oxybate in Patients With Chronic Fatigue Syndrome Related Papers Related Patents Related Grants Related Experts Highlight: Chronic fatigue syndrome (CFS) is a disabling, unexplained disorder characterized by physical and mental exhaustion. Complaints of disturbed and unrefreshing sleep are very common in CFS patients, however, the relationship between (disturbed) sleep quality and fatigue is still not fully elucidated. To evaluate the effect of sodium oxybate on fatigue and to explore the interdependence of sleep quality and fatigue in CFS, a double blind, randomized, … |
AN MARIMAN; | 2015-12-01 |