Clinical Digest: Recent Clinical Trials on Chronic Obstructive Pulmonary Disease (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Chronic Obstructive Pulmonary Disease. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Chronic Obstructive Pulmonary Disease (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | A Randomized, Sham Controlled Clinical Trial to Assess The Effectiveness of A Positive End Expiratory Device for Accelerating and Maintaining Pulmonary Rehabilitation Gains PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, the investigators will test Veterans with COPD in Pulmonary Rehabilitation. Between two groups, the investigators will give one group a device that assists with breathing and symptoms and the other receives a ‘sham’ device which does not provide these benefits. The investigators will test to see if the symptoms and exercise capacity of the group who receives this device improves faster in Pulmonary Rehabilitation and has longer lasting benefits after the end of Pulmonary Rehabilitation. |
ROBERT MATTHEW BURKES; | 2026-02-17 |
| 2 | Association Between SLC25A48 Expression and Chronic Obstructive Pulmonary Disease Progression PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the expression level of SLC25A48, a mitochondrial choline transporter, in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease, and to analyze its correlation with inflammatory markers and choline metabolic byproducts. |
KE-YUN CHAO; | 2026-03-17 |
| 3 | Respiratory Benefits of Indoor Air Purification in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized, double-blind, parallel-controlled trial aims to evaluate the effects of an indoor air purifier intervention on respiratory health in patients with Chronic Obstructive Pulmonary Disease (COPD). |
HAIDONG KAN; | 2026-04-01 |
| 4 | Assessment of Malnutrition in Hospitalized Patients: A Quasi Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Malnutrition among hospitalized patients is a critical, yet often overlooked, public health issue associated with increased complications, longer hospital stays, higher mortality, and greater healthcare costs. In Iraq, factors such as dietary patterns, the burden of chronic diseases, and healthcare constraints may increase the risk of hospital-acquired malnutrition. Current standard care may not include systematic nutritional screening or protocol-driven support. This trial aims to test whether implementing an individualized nutritional support program can improve clinical outcomes for at-risk medical inpatients in Iraqi hospitals, building upon evidence from international studies |
ALFAYHAA GENERAL HOSPITAL | 2026-03-16 |
| 5 | The Effect of Acupuncture on Pulmonary Function Recovery Following Lung Resection: A Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background and Purpose: Lung resection surgery is the standard treatment for early-stage lung adenocarcinoma, but it often leads to reduced lung volume and postoperative pain, which can hinder pulmonary recovery. While standard rehabilitation includes breathing exercises (incentive spirometry) and pain management, additional strategies are needed to enhance recovery. Acupuncture has shown benefits in managing respiratory diseases like COPD and reducing surgical pain, … |
CHUNG SHAN MEDICAL UNIVERSITY | 2026-03-02 |
| 6 | Feasibility Pilot Trial of A Pharmacist-led Medication Management Intervention for Multi-Morbid Adults With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A pilot trial to examine feasibility of a pharmacist-led intervention for patients with COPD (Chronic Obstructive Pulmonary Disease) and multimorbidity to improve medication safety and reduce dyspnea. Patients will receive inhaler teaching and medication optimization counseling. Outcomes include feasibility, acceptability, appropriateness, and exploratory measures such as medication discontinuation and patient-reported symptom burden. |
CARA MCDERMOTT; | 2026-03-06 |
| 7 | Type III/IV Muscle Afferents in Airway and Thermoregulatory Responses PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Exercise places serious demands on the body. These demands are fundamentally caused by increases in oxygen demand and the consequent increase in body temperature. These demands are met by several physiological responses, including increases in heart rate, blood pressure, breathing and blood flow. These responses must be proportional to the increase in demand and some signal must relay information from the muscle to the brain. Group III/IV afferents do just this. They relay information about the muscle (movement, temperature, acidity, … |
TRAVIS D GIBBONS; | 2026-03-05 |
| 8 | Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the impact of acute kidney injury (AKI) on the success rate, duration, and complications of weaning from mechanical ventilation in critically ill adult patients admitted to the intensive care unit (ICU), and to identify whether AKI is an independent predictor of difficult, failed or complicated or weaning. |
ASMAA ADEL; | 2026-03-17 |
| 9 | Effect of High-intensity Interval Training on The Lung in Patients With COPD Referred for Lung Volume Reduction Surgery: The PREGENERATE Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Patients with chronic obstructive lung disease (COPD) suffer from a progressive loss of lung function that leads to poor quality of life, and often invalidity and early death. Regular exercise can improve quality of life in these patients, but there is a lack in understanding the underlying mechanism of exercise-induced improvement in COPD and it is widely thought not to have any effect on the lung as such. In the present study, … |
RONAN BERG; | 2026-04-02 |
| 10 | Impact of High Biomechanical Efficiency Footwear on Six-Minute Walk Test Performance in Chronic Obstructive Pulmonary Disease (COPD): A Randomised Cross-Over Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: COPD: A Leading Cause of Respiratory Disability COPD, primarily linked to smoking, affects 3.5 million people in France and causes 15,000 deaths each year. It is a major source of disability, particularly due to dyspnoea, which affects one in three patients. Around 400,000 patients are registered under long-term conditions (ALD), and 200,000 receive home-based respiratory support. The most severe cases fall under the category of chronic respiratory failure-a term also applicable to other respiratory or neuromuscular diseases. Walking Exposes Physical Limitations In patients with respiratory failure, walking rapidly induces disabling dyspnoea, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2026-03-03 |
| 11 | Evaluation of The Effectiveness of A Pharmacist-Led Interactive Mobile Health Intervention (Serious Games) for Improving Health Outcomes in Adults With COPD (Pilot RCT) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to evaluate the effectiveness of a pharmacist-led interactive mobile health intervention (serious game) in adults aged 50 years and older with chronic obstructive pulmonary disease (COPD). The study will test whether the intervention improves health status compared with usual care. Secondary outcomes include inhaler technique, medication adherence, health knowledge, dyspnea, clinical events, healthcare utilization, and costs. Participants in the intervention group will receive pharmacist guidance and use the serious game at home for 2 weeks. |
GALUH NAWANG PRAWESTI; | 2026-03-27 |
| 12 | Home Oscillatory Positive Expiratory Pressure Combined With Aerobic Exercise in Moderate to Severe COPD Patients: A Multicenter, Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the feasibility and effectiveness of home OPEP therapy and aerobic exercise training in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD) who are at high risk of acute exacerbations, aged 40-80 years. The main questions it aims to answer are: Does home OPEP therapy, aerobic exercise training, or the combination of both reduce the incidence and hospitalization rate of acute exacerbations of COPD compared to conventional treatment? What are the effects of these interventions on 6-minute walk distance, all-cause mortality, lung function, quality of life, … |
HUIQING GE; | 2026-03-25 |
| 13 | Effect of Pulmonary Rehabilitation in Females With Acute Exacerbation of COPD Induced By Biomass Fuel Smoke Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: COPD represents an important public health challenge that is both preventable and treatable. GOLD is committed to improving the health of people at risk of and with COPD, wherever they happen to have been born, and wishes to do its bit to help achieve the United Nations Sustainable Development Goal to reduce premature mortality from non-communicable diseases – including COPD – by one third by 2030. GOLD aims in stable COPD to relieve symptoms, improve exercise tolerance and improve health status. Non-pharmacological interventions for those high-risk groups of patients, … |
BENI SUEF UNIVERSITY | 2026-04-03 |
| 14 | An Exploratory Clinical Study on The Intravenous Infusion of REGEND007 (Generic Airway Basal Layer Stem Cells) for Treatment of Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide with the characterization of obstructed airflow. In a large number of patients, diffusion function is impaired along with the progression of disease. REGEND007 cell therapy, comprised of airway basal cells with ability to regenerate lung tissue, is promising to COPD treatment. A prospective, single-arm, dose-escalation exploratory clinical study to evaluate the safety, tolerability and preliminary efficacy of different doses of REGEND007 cell therapy administered by intravenous infusion in the treatment of COPD, and to recommend appropriate treatment doses for subsequent clinical studies. |
REGEND THERAPEUTICS | 2026-03-23 |
| 15 | Decision-making and Optimization of Ventilatory Support for AECOPD Patients PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The main questions it aims to answer are: 1. How are different respiratory support modalities selected for patients with AECOPD in real-world practice? 2. What clinical patterns are associated with escalation, de-escalation, switching, or discontinuation of respiratory support during hospitalization? Researchers will review de-identified hospital records of patients admitted with AECOPD and analyze the dynamic use of respiratory support during hospitalization, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, … |
HUIQING GE; | 2026-04-02 |
| 16 | Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB PURE) A Randomized Multi-Centre Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Individual-level, unblinded randomized controlled trial of an 8-week (short arm) or 24-week (extended arm) pulmonary rehabilitation program, relative to standard of care, to prevent post-tuberculosis respiratory morbidity. Randomization will occur in a 1:1:1 ratio at the initiation of treatment. |
AKSHAY GUPTE; | 2026-03-27 |
| 17 | Clinical Study on Guben Kechuan Granules Promoting Disease Recovery By Regulating Immune-Inflammatory Dysregulation in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease During The Peri-Discharge Period PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic airway diseases in China. Western medicine treatments have good clinical efficacy, but their effectiveness is limited in patients with Acute Exacerbation of COPD (AECOPD) during the peri-discharge period. Recurrent acute exacerbations remain an urgent clinical challenge to address. Traditional Chinese Medicine (TCM) has certain advantages in treating chronic airway diseases. Among them, Guben Kechuan Granules are widely used in respiratory diseases such as emphysema and COPD. However, high-level evidence for the use of Guben Kechuan Granules in patients with AECOPD during the peri-discharge period is currently lacking, … |
CUILING FENG; | 2026-03-06 |
| 18 | The Effect of Preoperative Nebulized Lidocaine and Nebulized 3% NaCl Premedication on Postoperative Respiratory Complications in Pediatric Patients Undergoing Adenoidectomy And/or Adenotonsillectomy Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective, randomized clinical trial aims to evaluate the effect of preoperative nebulized lidocaine and nebulized 3% hypertonic sodium chloride (NaCl) on the incidence of postoperative respiratory complications in pediatric patients undergoing adenoidectomy and/or adenotonsillectomy. Lidocaine, a versatile sodium channel blocker, has shown antitussive, bronchodilatory, and anti-inflammatory benefits when nebulized, and has been safely used in children for respiratory procedures. Hypertonic 3% NaCl is known to improve mucociliary clearance, reduce airway edema, and enhance secretion mobilization, particularly in pediatric respiratory conditions. Both agents have demonstrated individual safety and efficacy in respiratory management, … |
BURÇIN ALAÇAM; | 2025-12-05 |
| 19 | Early Effects of Different Inspiratory Muscle Training on Disease Clinical Course, Respiratory Parameters, Functional Capacity and Quality of Life in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: COPD is one of the most life-threatening pulmonary diseases. According to the World Health Organization, it is expected to rise to the third leading cause of death by 2030. Smoking is the most significant contributing factor. COPD reduces lung volumes and causes dyspnea. Over time, respiratory muscle weakness develops, leading to hypercapnia, dyspnea, nocturnal oxygen desaturation, … |
ERDİ KAYABINAR; | 2026-03-16 |
| 20 | Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this cluster randomized controlled trial is to determine the optimal treatment for Acute Exacerbation of Chronic Obstructive Pulmonary Disease. The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 40 years old diagnosed with chronic obstructive pulmonary disease with acute exacerbation. The main question is whether there is a difference in readmission for COPD excerbation or all cause mortality within thirty days. Participants will randomized to receive treatment with either hydrocortisone or prednisolone. |
COPENHAGEN RESPIRATORY RESEARCH | 2026-03-18 |
| 21 | Clonal Fetal Mesenchymal Stem Cell Therapy for The Treatment of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objectives are to evaluate the safety and efficacy of infusion of fully characterized clonally derived fetal mesenchymal stem cells (cfMSCs) for the control of severe symptoms associated with moderate to severe chronic obstructive pulmonary disease. |
SHENZHEN GENO IMMUNE MEDICAL INSTITUTE | 2026-03-25 |
| 22 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Study to Evaluate The Efficacy and Safety of RC1416 Injection in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, double-blind, placebo-controlled phase II clinical study to evaluate the efficacy and safety of RC1416 injection in patients with moderate to severe chronic obstructive pulmonary disease (COPD). |
NANJING REGENECORE BIOTECH | 2026-02-11 |
| 23 | The Effect of Telenursing Interventions on Oral Health in Individuals With COPD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research will be conducted using a pre-test and post-test control group experimental design to evaluate the effect of telenursing intervention on oral health in individuals with COPD. |
SEVDA ATEŞ; | 2026-03-10 |
| 24 | Assessing and Improving Misuse of Inhalers in Outpatients With COPD – The AIMO COPD Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is a common long-term lung disease that causes breathlessness, cough, and frequent flare-ups. Most patients with COPD use inhaled medications every day. However, many people do not use their inhalers correctly, or they cannot generate the right inspiratory flow for their device. When inhalers are used incorrectly, the medication does not reach the lungs properly, symptoms worsen, … |
HÔPITAL FRIBOURGEOIS | 2025-12-04 |
| 25 | A Comparative Study of Ultrasonic and Conventional Spirometers in Patients With Chronic Respiratory Diseases PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study compares a handheld ultrasonic spirometer with a standard hospital spirometer in adults with chronic respiratory diseases. Each participant will complete lung function tests using both devices. The study aims to determine whether the ultrasonic device provides accurate and reliable measurements for use in clinical or home settings. |
KE-YUN CHAO; | 2026-03-12 |
| 26 | Examining The Effectiveness of Single-Limb Exercise Training for COPD Patients During Exacerbation Periods PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Resistance exercise applications during acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are employed to enhance functional capacity and prevent muscle atrophy by increasing muscle strength. Owing to the limited cardiorespiratory reserve of COPD patients, … |
ALPER KEMAL GÜRBÜZ; | 2026-01-16 |
| 27 | Evaluation of Safety Profile in A Cohort Study of Inhaled TQC3721 Suspension in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the safety of inhaled TQC3721 Suspension in patients with moderate to severe Chronic Obstructive Pulmonary Disease |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2026-03-11 |
| 28 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of Subcutaneous JKN2401 Injection in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) PF:4 Related Papers Related Patents Related Grants Related Experts |
JOINCARE PHARMACEUTICAL GROUP INDUSTRY | 2026-01-14 |
| 29 | Effects and Mechanisms of Online Delivered Singing Training Vs Usual Care in Patients With Persistent Symptoms 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC) – A Multi-centre RCT PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning. Current Danish rehabilitation offers are heterogeneous and inconsistent and not tailored to the specific needs of this population. Additionally, some patients continue to suffer from persistent physical symptoms months or even years after surgery, yet no targeted support is currently available for them. Singing – delivered as a structured form of training – … |
METTE KAASGAARD; | 2026-04-02 |
| 30 | A Multicenter, Single-Arm, Open-Label Study to Evaluate The Long-Term Safety and Efficacy of HSK39004 Dry Powder Inhaler in Patients With Chronic Obstructive Pulmonary Disease (COPD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial evaluates the long-term safety and efficacy of 0.75 mg HSK39004 Dry Powder Inhaler administered twice daily for 52 weeks in subjects aged 40 to 80 years with moderate-to-severe stable chronic obstructive pulmonary disease (COPD), including both newly enrolled and those who have completed prior participation in the HSK39004-201, HSK39004-T1-201, or HSK39004-T1-202 studies as a long-term extension. |
HAISCO PHARMACEUTICAL GROUP | 2026-02-20 |
| 31 | Mortality Predictors After Major Abdominal Surgery in Patients Aged 80 and Over: The Role of Frailty and Physiological Reserve PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to identify independent risk factors for 30-day mortality in patients aged 80 and over who have undergone major abdominal surgery. While traditional risk scoring systems often focus on chronic disease burden, they may not fully capture the biological decline associated with aging. This research specifically focuses on the predictive value of frailty and physiological reserve in determining surgical outcomes for this old-old patient population. In this retrospective cohort study, data from approximately 200 patients treated between 2022 and 2025 will be analyzed. Frailty will be assessed using the Modified Frailty Index (mFI-5), … |
MUSTAFA KEMAL ŞAHİN; | 2026-02-27 |
| 32 | A Randomized Crossover Trial of Indoor Air Quality Improvement on Health in Patients With Interstitial Lung Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Air pollution threatens the respiratory health of patients with interstitial lung disease (ILD). High-efficiency air purifiers, featuring easy operation and excellent particulate matter removal efficiency, have been shown in previous studies to potentially delay lung function deterioration and reduce acute exacerbation risk in respiratory disease patients. This randomized crossover study employs air purifiers to filter indoor gaseous pollutants, allergens, and other contaminants, aiming to alleviate respiratory irritation, improve daily life comfort, and enhance overall health status in ILD patients. |
HONGBING XU; | 2026-01-15 |
| 33 | Fractional Exhaled Nitric Oxide (FeNO) As A Predictor of Exacerbations in COPD Patients Initiated on Triple Inhaler Therapy: A Prospective Exploratory Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with recurrent exacerbations despite guideline-based therapy. This prospective observational cohort study aims to evaluate whether baseline fractional exhaled nitric oxide (FeNO), a biomarker of type 2 airway inflammation, predicts future exacerbations and lung function decline in COPD patients initiated on triple inhaler therapy in routine clinical practice. The study will also explore the relationships between air pollution exposure, type 2 inflammatory biomarkers, and COPD outcomes. |
TING-YU LIN; | 2026-02-09 |
| 34 | Pulmonary Rehabilitation in Advanced Lung Cancer Survivors PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is for people who have previously been diagnosed with advanced stage non-small cell lung cancer (NSCLC). Many people with advanced stage NSCLC have trouble breathing and feel tired. People may be eligible for this study if they have advanced stage NSCLC and feel short of breath some of the time. NSCLC survivors may also experience things like fatigue and a lower quality of life. Pulmonary rehabilitation is a type of supportive treatment that may improve these symptoms. This study has two parts. The first part is a randomized trial where half of the participants receive eight weeks of pulmonary rehabilitation. The other half of participants do not do pulmonary rehabilitation and instead receive the treatment that their doctors would normally recommend. The purpose of this part of the research study is to understand if pulmonary rehabilitation can help people with advanced stage NSCLC have better functioning and less shortness of breath. The other part of the research study is an interview study. The purpose of doing interviews is to understand any challenges or obstacles that people with advanced stage NSCLC may have regarding pulmonary rehabilitation, as well as oncology care providers have with their participants going to pulmonary rehabilitation. |
MELINDA HSU; | 2026-02-19 |
| 35 | The Effect of Probiotics on The Degree of Dyspnea, Lung Function, and Inflammatory Mediators in Patients With Chronic Obstructive Pulmonary Disease (COPD). PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized, placebo controlled, double-blind clinical trial is to find out whether a probiotic supplement can help adults with chronic obstructive pulmonary disease (COPD) breathe better and better control their symptoms. The study will try to answer does taking a probiotic supplement, compare with a placebo, reduce shortness of breath, does it improve daily COPD symptoms or change stool patterns by using validated questionnaires; does it affect lung function or inflammation. The results of this study may contribute to a better understanding of the disease, the application of new therapeutic options, … |
ANDREA ANIĆ MATIĆ; | 2026-03-05 |
| 36 | Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate the safety and tolerability of Metformin and how it changes blood markers associated with aging in persons who have chronic obstructive pulmonary disease (COPD) who do not have diabetes. |
CHRISTOPHER MOSHER; | 2025-12-10 |
| 37 | Functional Assessment and Pulmonary Rehabilitation: Challenges and Perspectives for Comprehensive Care PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Individuals with Chronic Obstructive Pulmonary Disease (COPD) present with respiratory muscle dysfunction, characterized by reduced diaphragmatic contractility and mobility due to pulmonary hyperinflation, oxidative stress, and systemic inflammation. Effective assessment of diaphragmatic function is crucial for monitoring progress in pulmonary rehabilitation programs. This study aims to evaluate diaphragmatic function and mobility in COPD patients undergoing pulmonary rehabilitation with inspiratory muscle training, using ultrasound, and to identify associations between diaphragmatic dysfunction and clinical symptoms such as dyspnea and fatigue. A randomized clinical trial will be conducted to investigate the impact of rehabilitation on diaphragmatic function, … |
GLEIDIANE LORRANA SALES DOS SANTOS; | 2026-02-17 |
| 38 | Effects of Myofascial Release in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this study is to assess the effects of a myofascial release protocol in patients with chronic obstructive pulmonary disease (COPD). |
ARGUISUELAS MARTINEZ MARÍA DOLORES; | 2025-02-12 |
| 39 | Mechanistic 129-Xe MRI Study of Single Inhaler FF/UMEC/VI Effects in COPD Patients With Persistent, Moderate-severe Dyspnea And/or Poor Health Status With High or Low Risk of Exacerbation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to study how 12-weeks daily (and optional 48-weeks) single inhaler triple therapy (fluticasone furoate (FF)-an inhaled corticosteroid; umeclidinium (UMEC)-a long-acting muscarinic antagonist; … |
GRACE PARRAGA; | 2025-09-25 |
| 40 | A Structured Health Assessment in Frequent COPD Exacerbators: To Optimise Management, Identify Comorbidities and Prevent Oral Corticosteroid Related Harm PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Chronic obstructive pulmonary disease (COPD) is a serious lung condition and the third leading cause of death worldwide. People with COPD have sudden and distressing flare-ups (exacerbations). These can be triggered by infections or occur without a clear cause. Flare-ups often lead to hospital admission, can cause a lasting health decline, increase the risk of dying and are strongly liked to lower income. Sometimes, people are wrongly diagnosed with COPD, when they have a different health issue. Other diseases (like heart conditions) are common in people with COPD, … |
RUTH E SOBALA; | 2026-03-10 |
| 41 | A Multicenter, Prospective Trial Evaluating The Safety and Efficacy of The Implantable Artificial Bronchus (IAB) in Adults Suffering From Severe Emphysema PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A study taking place at multiple sites in the United States, Europe and Brazil to evaluate how well a new therapy for severe COPD/emphysema works, and how safe it is. |
GEORGE CHENG; | 2026-03-24 |
| 42 | Erdosteine Effect on Oxidative Stress, Inflammatory Response and Immune Modulation in Patients With COPD. A Single Center, Open Label, Double Arm, Controlled, 4-week, Explorative, Ex Vivo Study. PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) remains a major contributor to global morbidity and mortality, exposing healthcare systems to a significant economical and social load. Indeed, acute severe COPD exacerbations are the events that contribute most to the overall disease burden. Current management strategies are aimed at maximizing symptom-free periods, reduce hospitalizations, improve exercise tolerance, overall health status, and quality of life. Key pathophysiological mechanisms involved in COPD exacerbations (defined as acute worsening of respiratory symptoms) include oxidative stress, acute on chronic inflammation, and mucus hypersecretion. Agents with antioxidant, anti-inflammatory, … |
PIERACHILLE SANTUS; | 2026-01-12 |
| 43 | Effect of Low-Dose Versus High-Dose Alpha-Lipoic Acid on Oxidative Stress, Inflammation, and Clinical Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a progressive inflammatory lung disease characterized by persistent airflow limitation and enhanced oxidative stress. Acute exacerbations of COPD (AECOPD) significantly increase morbidity, accelerate lung function decline, and worsen clinical outcomes. Oxidative stress plays a central role in AECOPD pathophysiology by amplifying inflammation through mediators such as IL-8 and TNF-α, leading to airway injury and impaired gas exchange. Alpha Lipoic Acid (ALA) is a potent antioxidant and anti-inflammatory agent that scavenges reactive oxygen species, regenerates endogenous antioxidants, and modulates redox-sensitive inflammatory pathways. Although preclinical evidence supports its protective role in respiratory diseases, … |
EMAN MOHAMED EL MOKADEM; | 2026-03-30 |
| 44 | A Multicenter Study of The Impact of A COPD Identification and Referral System on Patient Follow Up and Outcomes After An Acute COPD Exacerbation Resulting in An Emergency Department Visit or Hospitalization PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to evaluate the impact of implementing an AI-enabled clinical workflow tool (Viz COPD) on respiratory specialist follow up and clinical outcomes after an acute exacerbation. |
RAMYA LOTANO; | 2026-04-01 |
| 45 | Integrative Medicine Program for COPD With Comorbidity Management PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is a major chronic respiratory condition with high prevalence of multimorbidity. COPD and comorbidities interact dynamically, contributing to symptom fluctuation, acute exacerbations, hospitalization, and long-term disease progression. The IMPACT COPD Cohort (China) is a multicenter prospective observational cohort designed to establish a real-world evidence base for integrative Chinese-Western medicine management of COPD with comorbidities. The cohort integrates conventional clinical assessments (symptoms, questionnaires, spirometry, imaging, and biomarkers) with continuous multisensor digital monitoring (e.g., heart rate, blood pressure, activity, sleep patterns, and other physiological and behavioral measures) and digital Traditional Chinese Medicine (TCM) phenotyping (e.g., tongue, pulse, … |
BEIJING CHAO YANG HOSPITAL | 2026-03-19 |
| 46 | Clinical Application Study of Chronic Obstructive Pulmonary Disease Screening Using Artificial Intelligence-Based Acoustic Features PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality worldwide, yet early detection remains challenging-especially in primary care settings where spirometry, the diagnostic gold standard, is often unavailable. This study aims to develop and validate a non-invasive, low-cost COPD screening tool based on artificial intelligence (AI) analysis of cough sounds. Using smartphone-recorded cough audio and clinical data from both COPD patients and non-COPD controls, the investigators will train and test an AI model to identify acoustic signatures associated with COPD. The model will be developed using a prospective cohort from Sir Run Run Shaw Hospital, … |
HUIQING GE; | 2026-03-25 |
| 47 | Strategy for EArly Recognition of Cancer, COPD & Heart Failure in The Emergency Department PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: SEARCH-ED is a research study which is running in Emergency Department (ED) of the Queen Elizabeth University Hospital. The aim of the study is to find out if using a computer programme can help doctors diagnose heart and lung problems from chest x-rays. We want to compare how many people are diagnosed with heart or lung problems for the first time when doctors have access to the computer programme results, in comparison to when they don’t. |
DAVID J LOWE; | 2026-02-05 |
| 48 | A Multicenter, Randomized, Study to Evaluate Safety and Efficacy After Treatment With The DNerva Lung Denervation System in Subjects With Chronic Obstructive Pulmonary Disease (COPD) (AIRFLOW-4) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The dNerva Lung Denervation System is one-time treatment intended to improve breathing in Chronic Obstructive Pulmonary Disease (COPD) patients on standard medical care. The purpose of this study is to confirm the safety and efficacy of the Nuvaira Lung Denervation System in the treatment of COPD. |
GERARD CRINER; | 2026-02-27 |
| 49 | Effects Of Low-Load Blood Flow Restriction Training Of The Upper Extremity In Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airflow limitation, progressive dyspnea, and peripheral muscle dysfunction, significantly impairing functional capacity and quality of life. Although the combined implementation of aerobic and resistance exercises is recommended in pulmonary rehabilitation programs, early-onset ventilatory limitation in individuals with COPD often hinders tolerance to high exercise intensities. This limitation increases the need for alternative exercise approaches targeting peripheral muscle adaptations. Low-load blood flow restriction training (LL-BFRT), which enables improvements in muscle strength with low mechanical loads, has emerged as a potential option for this patient population. However, … |
ZEYNAL YASACI; | 2026-03-13 |
| 50 | Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD (COPD-OMA) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This research is being done to test if a drug called omalizumab can help people with Chronic Obstructive Pulmonary Disease (COPD) and allergies. Each participant will be in the study for about 16 months, including 1-3 months of screening, 12 months of receiving the study drug at a clinic, and a follow-up call one month after your final clinic visit. |
NIRUPAMA PUTCHA; | 2026-02-17 |
| 51 | AN INTERVENTIONAL PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, THIRD PARTY-UNBLINDED, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF PF-07275315 IN ADULT PARTICIPANTS WITH MODERATE-TO-SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, … |
PFIZER | 2026-03-27 |
| 52 | An Investigation of The Effects of Manual Therapy on The Spatiotemporal Gait Characteristics in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim of this study is to investigate the effects of manual therapy on spatiotemporal characteristics of gait and gait variability, functional exercise capacity, and pulmonary function in patients with chronic obstructive pulmonary disease (COPD). The secondary aims of the study are to determine the effects of manual therapy on balance, respiratory muscle strength, quality of life, physical activity, symptom severity, accessory respiratory muscle activation, peripheral muscle strength, chest wall mobility, dysfunctional breathing, pain, and posture. |
AYNUR DEMIREL; | 2026-02-02 |
| 53 | A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Safety, Tolerability and Pharmacokinetics of HY6725 Following Single and Multiple Subcutaneous Doses in Healthy Participants PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn the safety, tolerability and pharmacokinetics of single and multiple doses of HY6725 in healthy adult participants. The main questions it aims to answer are: * How is the safety and tolerability following administration of single and multiple doses of HY6725 in healthy adult participants? * What is the PK character of HY6725 following administration of single and multiple doses of HY6725 in healthy adult participants? Researchers will compare HY6725 to a placebo (a look-alike substance that contains no drug) to see if HY6725 is safe and well tolerated. Participants will take HY6725 or a placebo once or twice in single dose group or multiple dose group. And will be follow-up until Day 150. |
PHILIP RYAN; | 2026-03-11 |
| 54 | Prevalence and Functional Impact of Urinary Incontinence in Women With Chronic Obstructive Pulmonary Disease Undergoing Rehabilitation: A Cross-sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a pathology characterized by progressive bronchial obstruction associated with an abnormal inflammatory response, leading to chronic cough, increased bronchial secretions, and irreversible destruction of alveolar walls according to the French-Language Pulmonology Society, in 2023, over 1.3 million patients were treated for this condition in France. The World Health Organization ranks COPD as the third leading cause of mortality worldwide. Historically, COPD predominantly affected men due to higher smoking rates. However, with the rise in smoking among women, … |
CHRISTOPHE ROMANET; | 2026-02-02 |
| 55 | Investigation of The Effects of Oxidized Antigens on The T-Cell Response and The Epigenetic Reprogramming of Neutrophils in Lung Diseases – OXIGENE – PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The OXIGENE study is a research project that aims to better understand how the immune system behaves in people with lung diseases such as asthma, COPD, pneumonia, tuberculosis, and viral lung infections. By analyzing a single blood sample, the study examines how certain immune cells react during inflammation and infection, and whether lasting changes in these cells influence how strongly the body responds to disease. Although participants do not receive direct medical benefit, the results may help improve future diagnosis and treatment of lung diseases by providing deeper insight into immune responses. |
JAN HEYCKENDORF; | 2026-02-04 |
| 56 | Impact of Comorbiditries and Disease Severity on Clinical Outcomes of Patients With Acute Exacerbations of Bronchiectesis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Acute exacerbations of bronchiectasis are associated with variable outcomes depending on patient factors. Comorbidities such as COPD, diabetes, and cardiovascular disease, as well as disease severity scores, significantly influence hospitalization rates, length of stay, need for intensive care, and mortality. Understanding these associations helps in risk stratification, guiding management, and improving prognosis in affected patients. |
ALIAA ELSAYED MAHMOUD; | 2026-01-16 |
| 57 | Evaluation of The Efficacy and Safety of RSS0343 Tablets in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Phase II, Randomized, Double-blind, Placebo-controlled Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical trial designed to evaluate the efficacy and safety of RSS0343 tablets in patients with COPD. The study includes 3 study periods: a 4-week screening period, a 48-week treatment period, and a 4-week follow-up period. The primary endpoint is the annualized rate of moderate or severe exacerbations of COPD during the 48-week treatment period. |
WEIJIE GUAN; | 2026-01-16 |
| 58 | Bronchodilator Response in COPD and Asthma: Correlation Between Spirometry, IOS Indices, and Dyspnea Relief PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A bronchodilator reversibility test is widely used in the diagnosis and management of obstructive lung diseases. Bronchodilators relieve symptoms in asthma and COPD. Traditionally, their effectiveness has been assessed using spirometric indices, particularly FEV₁. However, changes in FEV₁ often do not correlate well with patients’ subjective experience of dyspnoea relief or with changes in small airway function. Impulse oscillometry (IOS) provides an effort-independent assessment of respiratory mechanics during tidal breathing and is more sensitive to small airway dysfunction than spirometry. Despite this, the clinical utility of IOS in routine COPD and asthma assessment remains underexplored, … |
THOMAS J RINGBÆK; | 2026-01-26 |
| 59 | Inducing Variable Breathing Ratios During Walking to Improve Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed to provide information regarding how to improve pulmonary rehabilitation for persons with chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation is an exercise program for COPD patients that is recommended and benefits some, but not all, patients. The question being studied in this trial is whether during an exercise program, walking on an incline might be better than walking on faster on a flat surface in training muscles so that patients might be less short of breath with exercise. |
KRISTINA L BAILEY; | 2025-12-04 |
| 60 | Comparative Effects of Breather Device and Incentive Spirometer on Dyspnea , Lung Function Tests and Quality of Life in Patients With Copd PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is characterized and defined by limitation of expiratory airflow. This can result from several types of anatomical lesions, including loss of lung elastic recoil and fibrosis and narrowing of small airways. Inflammation, edema, and secretions also contribute variably to airflow limitation.it is a preventable and treatable disease characterized by persistent airflow limitation and respiratory symptoms, leading to cough, dyspnea, muscle weakness and fatigue affecting overall well-being and quality of life. The Breather is a respiratory muscle training device strengthening both inspiratory and expiratory muscles by breathing against a set resistance, … |
WAJEEHA ZIA; | 2026-02-27 |
| 61 | Home-based Pulmonary Rehabilitation for COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objectives The objective of this project is to motivate patients with COPD to incorporate the habit of doing daily mindful physical activity by using the proposed home-based pulmonary rehabilitation program that integrates video guided exercises, … |
MARIAN PAPP; | 2025-07-01 |
| 62 | A Real-World Study Evaluates The Clinical Characteristics and Effectiveness of COPD Patients Treated With The Triple Combination Beclometasone Diproprionate/Formoterol Fumarate/Glycopyrronium Bromide (BDP/FF/GB) in A Single Pressurised Metered Dose Inhaler (Trimbow® PMDI) in Brazil PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This multicenter, retrospective-prospective, cohort study aims to evaluate the effectiveness and safety of Extra-fine Beclometasone Diproprionate/Formoterol Fumarate/Glycopyrronium Bromide (EF-BDP/FF/GB) therapy in adults with severe or very severe COPD in Brazil. Around 400 patients will be enrolled across approximately 15 sites. Eligible patients must have started treatment on the day of enrollment or up to three months before enrollment. Data will be collected both retrospectively and prospectively, with baseline information covering up to 12 months before treatment initiation. All assessments will occur during routine medical visits, … |
CHIESI FARMACEUTICA LTDA | 2026-02-12 |
| 63 | Non-invasive Hemodynamic Monitoring in COPD Patients Admitted to The Respiratory Intensive Care Unit: Reliability, Clinical Utility, and Ventilation-related Hemodynamic Changes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates the reliability and clinical usefulness of non-invasive electrical cardiometry (ICON® device) in monitoring hemodynamic changes in COPD patients admitted to the respiratory intensive care unit (RICU). |
YOUSEF THARWAT GERIS QRQAR; | 2025-10-06 |
| 64 | Turkish Validation of The Nijmegen Questionnaire in COPD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Dysfunctional breathing is a common and clinically relevant problem in patients with chronic obstructive pulmonary disease (COPD), contributing to increased dyspnea perception, reduced exercise tolerance, and impaired quality of life. The Nijmegen Questionnaire (NQ) is a widely used symptom-based instrument for screening dysfunctional breathing; however, a validated Turkish version for patients with COPD is currently unavailable. This observational methodological study aims to translate, culturally adapt, and evaluate the validity and reliability of the Turkish version of the Nijmegen Questionnaire (NQ-TR) in individuals with stable COPD. |
ESRA PEHLIVAN; | 2026-01-15 |
| 65 | Prospective and Retrospective Observational Real-world Study to Characterize Patients With COPD on Dupilumab Long-term Treatment, and Assess Safety and Patient Reported Outcomes PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The OBS19236 is a retrospective and prospective, non-interventional observational study in COPD patients treated with dupilumab as part of routine clinical care. It will follow-up about 350 to 500 participants over 36 months in up to 50 sites in France. |
SANOFI | 2026-03-17 |
| 66 | The Effect of Purse-Lip Breathing Exercise on Anxiety and Physiological Parameters Post-Bronchoscopy in Patients With COPD: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial investigates the effect of Pursed Lip Breathing (PLB) on anxiety levels and physiological parameters in patients with Chronic Obstructive Pulmonary Disease (COPD) following bronchoscopy. While PLB is known to improve oxygenation and ventilation in pulmonary rehabilitation, its specific impact on the immediate recovery period after bronchoscopy is understudied. The study aims to determine if nurse-led PLB intervention significantly improves heart rate, blood pressure, oxygen saturation, and reduces anxiety compared to standard care. |
RUHAT TILKI; | 2026-01-23 |
| 67 | The Efficacy of Non-invasive Brain Stimulation on Cognitive Functions in Patients With Chronic Obstructive Pulmonary Disease: Double-Blinded Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to examine if non-invasive brain stimulation (NIBS) can enhance cognitive function with chronic obstructive pulmonary disease (COPD) population. The main questions it aims to answer are: * What is the possibility effect of using the NIBS on cognitive functions as well as the cardiopulmonary parameters in COPD population? * What is the relation between cognitive function parameters and cardiopulmonary parameters in COPD population who suffer from cognitive impairment (CI)? Researchers will compare NIBS to a sham-NIBS to see if NIBS works to improve cognitive function in COPD population. Participants will: Receive NIBS or a sham-NIBS 5 sessions/week for 3 weeks for 20 min each session. Visit the clinic at the beginning for baseline assessment then after the completion of the 3 weeks to reassess them. Outcome measures for cognitive parameters and pulmonary parameters will be taken pre and post NIBS intervention |
SHAHAD ABDULRAHMAN ALKANDARI; | 2026-01-12 |
| 68 | Impact of Digital High-Intensity Respiratory Muscle Training on Ventilatory Function and Functional Capacity in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this Randomize control trail is to determine the effect of Digital High-Intensity Respiratory Muscle Training on ventilatory Function and Functional Capacity in Patients with COPD It will also learn about the safety and tolerability of this digital training program. The main questions it aims to answer are: Does digital high-intensity respiratory muscle training improve inspiratory and expiratory muscle strength (MIP and MEP)? ,Does it improve functional exercise capacity (6-minute walk distance) and lung function (FEV₁, FVC, FEV₁/FVC)? |
HAGAR WALY; | 2026-01-21 |
| 69 | A Prospective Study of Cardiovascular Risk of Patients Admitted for Acute Exacerbation of COPD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective study to assess the burden of existing or hidden cardiovascular (CV) and renal disease in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a Hong Kong public hospital setting. By implementing a chronic obstructive pulmonary disease (COPD) discharge care bundle with integrated CV/renal screening, the study aims to quantify undiscovered disease prevalence, evaluate risk factors for future exacerbations, and compare re-admission rates against historical controls, ultimately informing integrated cardiopulmonary management strategies. |
FANNY W.S. KO; | 2026-01-21 |
| 70 | Study on The Effects and Mechanisms of Modified Ma Xing Shi Gan Decoction in Treating Acute Exacerbations of Chronic Obstructive Pulmonary Disease Based on The Lung-Large Intestine Mutual Interior-Exterior Relationship PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study adopted a multi-center, randomized, controlled trial design. Patients with acute exacerbation of chronic obstructive pulmonary disease who met the inclusion criteria were randomly assigned to the experimental group and the control group. Both groups were treated under the guidance of the Expert consensus on the acute exacerbation of chronic obstructive pulmonary disease in China (revision in 2023) and the GOLD guidelines. The experimental group was treated with modified Maxing Shigan Decoction. The modified Ma Xing Shi Gan Decoction was administered twice a day for 14 days. Taking the length of hospital stay (days) of the patients as the primary efficacy indicator, and the TCM syndrome score, dyspnea score (mMRC), 6-minute walk test and mechanical ventilation demand rate as the secondary efficacy indicators, the clinical efficacy of modified Maxing Shigan Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease was evaluated. |
CUILING FENG; | 2026-02-11 |
| 71 | An Emotional-distress-based Integrated Care Programme in Patients With An Acute Exacerbation of COPD (EmoD) – A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators have developed a new counseling service that focuses on the emotional distress experienced by people living with COPD. The service has been specially developed for patients who have experienced a deterioration in their lung condition (known as an acute exacerbation of COPD). The new program is led by an APN team. Other professionals are involved in the program, … |
UNIVERSITY OF ZURICH | 2026-03-02 |
| 72 | Closed Loop Oxygen Control in COPD Patients Treated With Nasal High Flow in The Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients’ SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with hypoxemia/respiratory distress. |
FISHER AND PAYKEL HEALTHCARE | 2026-01-12 |
| 73 | The Effect of Home-based Inspiratory Muscle Training Compared to Usual Care on Readmission Rate in Patients After A Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Randomised, Multicentre, Parallel Group Clinical Trial: IN-SPIRED Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to test whether home-based inspiratory muscle training can reduce hospital readmissions and death in patients recovering from a severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The main questions this study aims to answer are: Does adding home-based inspiratory muscle training to usual care lower the risk of all-cause hospital readmission or death within 180 days after discharge? Does inspiratory muscle training improve respiratory muscle strength, symptoms of dyspnea, quality of life, … |
DANIEL LANGER; | 2026-04-01 |
| 74 | A Phase 2-Phase 3, Double-blinded, Randomized, Dose-repeating, Cross-over Study to Assess The Safety and Efficacy of Allogeneic ULSC on Disease Severity and Steroid Tapering in Participants With Dermatomyositis/ Polymyositis (DM/PM) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn about how an umbilical cord lining-derived stem cell (ULSC) product performs when treating Dermatomyositis/Polymyositis (DM/PM), also known as idiopathic inflammatory myopathy (IIM) in adults. It will assess safety and efficacy in relieving symptoms of DM/PM with ULSC administered in three intravenous (IV) doses of 150 million cells per dose. The main questions that this study plans to answer are: * Is ULSC as safe as placebo (a look-alike saline without cells) in repeated IV infusion? * Does ULSC improve symptoms of DM/PM after three doses? Researchers will compare ULSC to placebo and evaluate changes from baseline (before first dose) to after each dose and after all three doses are completed per treatment study period. * For participants undergoing steroid (e.g., prednisone) therapy for DM/PM, does ULSC allow their steroid dose to be reduced? Does ULSC reduce need for rescue therapy? Participants will have been diagnosed with either DM or PM: * Diagnosed according to the EULAR/ACR 2017 Classification Criteria for idiopathic inflammatory myositis (IIM), which includes DM and PM. * Positive for myositis-associated antibody or undergone evaluation to exclude mimics. Participants in this study will: * Participate for total of 25 months with 15 in-person clinic visits and 8 virtual visits on phone or video call. * Receive both ULSC and placebo for a total of 6 IV infusions (260 mL) 3 months apart. * Receive 3 doses of ULSC and 3 doses placebo in either of two sequences, as assigned: ULSC first and placebo second, or placebo first and ULSC second. * If undergoing steroid therapy, will have steroid dose taper prescribing lower doses starting two weeks after the second infusion. * Return for follow-up visits after each dose and up to 12 months after final dose. * Have follow-ups including self-reported questionnaires, physical exam, muscle strength and endurance tests, blood tests, pulmonary function tests, and other assessments. |
MICHAEL BUBB; | 2026-03-30 |
| 75 | The Effect of Pulmonary Rehabilitation on Inflammation and Oxidative Stress in COPD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, characterized by persistent airflow limitation, chronic inflammation, and increased oxidative stress. Despite optimal pharmacological treatment, many patients continue to experience symptoms, reduced exercise capacity, and frequent exacerbations. Pulmonary rehabilitation (PR) is an evidence-based, non-pharmacological intervention that improves symptoms, functional capacity, quality of life, and survival in patients with COPD; however, … |
DENIZ BILICI; | 2026-01-29 |
| 76 | A Prospective Cohort Study on Comprehensive Care of Sleep Disordered Breathing (Care-SDB Study) PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The Comprehensive Care of Sleep Disordered Breathing study (Care-SDB) is a prospective, multi-center, registry-based cohort study designed to investigate the integrated management of sleep-disordered breathing (SDB). The investigators aim to establish a nationwide SDB cohort and biobank to identify prognostic biomarkers, explore pathogenic mechanisms, and evaluate optimal treatment models. A total of 11,100 adult patients with recent sleep monitoring will be enrolled and followed longitudinally for up to 5 years. Data collection, including clinical outcomes and major adverse events, … |
SHAO-PING NIE; | 2026-01-21 |
| 77 | The COPD CARE Study: Evaluating The Impact of A Virtual-First COPD Service on Major Cardiac and Respiratory Events PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: A 12 month interventional study of up to 1,050 people with COPD to determine if the NuvoAir virtual-first clinical service leads to fewer moderate and severe COPD exacerbations and cardiac events, reduces healthcare utilization, and lowers the total cost of care compared to a control cohort that receives standard care only. |
KEN COHEN; | 2025-05-28 |
| 78 | Heart Failure With Preserved Ejection Fraction in Patients With Сhronic Obstructive Pulmonary Disease: Clinical Course and Prognosis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Study aim is comparison of heart failire with preserved ejection fraction (HFpEF) detection rate in patients with Сhronic Obstructive Pulmonary Disease (COPD) and the clinical course and prognosis in patients with COPD depending on HFpEF presence. |
DIANA I ABDULGANIEVA; | 2026-02-10 |
| 79 | High-Flow Nasal Cannula Versus Noninvasive Ventilation After Extubation in Patients With COPD and Mild Hypercapnic Respiratory Failure: A Prospective, Randomized Comparative Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) represent a leading cause of hospital admissions and respiratory intensive care unit (RICU) stays worldwide. After invasive mechanical ventilation, many COPD patients experience difficulty in the weaning process, with a high hazard of extubation failure due to persistent hypercapnia and weakened respiratory muscle function (1). Extubation failure is allied with increased morbidity, prolonged ICU stay, and higher mortality (2). Thus, effective post-extubation respiratory support strategies are central for improving outcomes in this susceptible group. Conventionally, … |
MONTASER GAMAL AHMED; | 2026-02-02 |
| 80 | A Randomized, Double-blind, Single-dummy, Positive Drug and Placebo-controlled, Parallel Group, Multicenter, Phase 2a Study to Evaluate The Efficacy and Safety of Hemay005 in Adult Participants With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A Multicenter, Randomized, Double-blind, Single-dummy, positive drug and placebo-controlled, Parallel Group, Phase 2a Study to Evaluate the Efficacy and Safety of Hemay005 in Adults with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD). |
GANZHOU HEMAY PHARMACEUTICAL | 2026-01-02 |
| 81 | The Association Between Problematic Media Use and Postoperative Pain Severity in Pediatric Patients Undergoing Tonsillectomy: An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims to investigate whether problematic media use is associated with postoperative pain severity in children aged 4-11 years undergoing tonsillectomy. A total of 94 parents who consent to participate and have children within the target age range will be included. Data will be collected using a structured questionnaire covering sociodemographic characteristics, family and child media habits, parental attitudes toward screen use, and the Problematic Media Use Scale (PMUS). Postoperative pain will be assessed using the FLACC scale at multiple time points within the first 24 hours after surgery. |
ALI GENC; | 2025-12-22 |
| 82 | Impact of Home Non Invasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease Discharged From Assiut University Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the impact of long-term home non-invasive ventilation (NIV) on patients with COPD |
MOSTAFA MAHMOUD AHMED ABDALLAH; | 2025-09-30 |
| 83 | A Study on Improving Sleep Quality in COPD Patients Through Inhalation Management Education By Nurses Using Video Conferencing Tools PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate whether inhalation management education provided by nurses improves sleep quality in patients with COPD. Inhalation management education includes training in inhalation techniques and guidance on how to use medications when symptoms occur. The main research question is: ・Does inhalation management education improve sleep quality in patients with COPD? Researchers will determine whether inhalation management education improves sleep quality compared to no education. Participants will: * Participate in two interviews with researchers using video conferencing tools. * Keep a diary recording their symptoms, sleep duration, and the frequency of rescue inhaler use. |
ASUKA HASHINO; | 2025-12-31 |
| 84 | Self-management Digital Intervention to Promote Physical Activity in People Living With Chronic Obstructive Pulmonary Disease: A Pilot Randomized Controlled Trial Study Protocol PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptability, and preliminary effects of a theory-based self-management digital intervention (Respir’air BPCO) designed to promote physical activity in patients with Chronic Obstructive Pulmonary Disease (COPD) after completion of a pulmonary rehabilitation program. The main question it aims to answer is: Is the Respir’air BPCO intervention (mobile app) feasible, acceptable, and preliminarily effective in increasing physical activity, enhancing self-management, improving motivation, and quality of life, while reducing dyspnea severity, exacerbations, and hospitalizations, … |
RICARDO SALGADO; | 2025-12-03 |
| 85 | Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This interventional study aims to investigate the acute effects of different types of exercise on cerebral and peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD). Functional near-infrared spectroscopy (fNIRS) and near-infrared spectroscopy (NIRS) will be used simultaneously to measure oxygenation changes in the prefrontal cortex and the vastus lateralis muscle during rest, Stroop task performance, the six-minute walk test, aerobic, strengthening, and breathing exercises. The study will compare COPD patients and age- … |
ESRA PEHLIVAN; | 2025-12-16 |
| 86 | A Study to Evaluate The Accuracy of Primary Care Diagnosis Using Oscillometry and Fractional Exhaled Nitric Oxide for Asthma and COPD Versus Specialist Diagnosis in Patients With Suspected Asthma or COPD PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Current diagnostic methods for asthma and chronic obstructive pulmonary disease mostly depend on pulmonary function tests, especially spirometry. While spirometry is a foundational tool, its diagnostic accuracy is often limited by the patient’s ability to perform forceful breathing maneuvers, as well as technical and reproducibility challenges, and the need for proper equipment and training. These constraints can compromise effective diagnosis of asthma and COPD in primary care settings. Prompt and accurate diagnosis by primary care physicians is essential for better patient outcomes. Although variable airflow limitation often measured as a change in FEV1 after bronchodilator is a hallmark of asthma, … |
ASTRAZENECA | 2026-03-17 |
| 87 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate The Efficacy and Safety of TQC3721 Inhalation Powder in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy and safety of TQC3721 inhalation powder in patients with moderate to severe Chronic obstructive pulmonary disease (COPD). |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2026-03-10 |
| 88 | A Multinational, Multicenter, Observational, Prospective Cohort Study for Assessing The Prevalence of Airflow Limitation in Outpatients With History of Smoking Attending Cardiology Clinics PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a global health concern, associated with structural lung abnormalities causing persistent airflow limitation (AL) and often result from cigarette smoking. In Turkey, COPD was ranked the third among the mortality causes and the eighth among disability causes, with 9.1% to 19.1% prevalence rate. In the Middle East and North Africa (MENA) region, an increase of 30.6% in age-standardized point prevalence occurred between 1990 and 2019, with an estimated 10.7 million COPD cases. Similarly, in the sub-Saharan Africa region, the highest COPD prevalence rate of 24.8% was observed in South Africa. And in Kenya, … |
ASTRAZENECA | 2026-03-30 |
| 89 | A Diagnostic Accuracy Study: N-Tidal Assessment for Respiratory Diagnosis Compared to Using Standard Testing PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The diagnosis of either asthma or chronic obstructive pulmonary disease (COPD) is currently based on a combination of symptoms, different lung tests and sometimes a ‘trial by treatment’. Both COPD and Asthma tests currently include forced breathing using a test known as spirometry which can be difficult and uncomfortable for people to perform and needs expert interpretation. Asthma can require multiple tests in sequence which can make the process of diagnosis long and inconvenient for patients. In the UK, there have been challenges providing enough testing for COPD and asthma, … |
LIVERPOOL HEART AND CHEST HOSPITAL NHS FOUNDATION TRUST | 2025-11-28 |
| 90 | Post-marketing Phase IV, Multicenter, Prospective Study to Observe The Safety and Tolerability of Breztri AerosphereTM Containing A Fixed Dose Combination of Budesonide 160 Mcg/ Glycopyrronium 7.2 Mcg/ Formoterol Fumarate Dehydrate 5 Mcg in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to observe the safety and tolerability of Breztri aerosphereTM as maintenance treatment in Indian patients with moderate to severe COPD. |
ASTRAZENECA | 2026-03-18 |
| 91 | The Effectiveness of An Innovative Inhalation Training Device in Improving Medication Accuracy, Dyspnea, and Quality of Life in Elderly Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effectiveness of an innovative inhaler training device, Golden Rhino (pMDI Practice Tool), in improving inhalation technique accuracy, dyspnea severity, and quality of life among elderly patients with chronic obstructive pulmonary disease (COPD). The device integrates a weighted valve and musical cues to guide patients in synchronizing their breath with proper pMDI inhalation technique. Participants will be randomly assigned to either standard nursing guidance or nursing guidance plus device-based training. Outcome measures include pMDI usage accuracy, dyspnea severity, and EQ-5D quality of life scores at baseline and follow-up. |
TAIPEI VETERANS GENERAL HOSPITAL TAIWAN | 2025-12-26 |
| 92 | A Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate The Efficacy and Safety of CM326 Recombinant Humanized Monoclonal Antibody Injection in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease（COPD） PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multi-center, randomized, double-blind, placebo-controlled Phase II clinical study to evaluate the efficacy, safety, PK characteristics, PD effects and immunogenicity of CM326 in subjects with moderate to Severe Chronic Obstructive Pulmonary Disease. The study consists of a screening period of up to 4 weeks, a randomized treatment period of 24 to 52 weeks, and a 12-week safety follow-up period. |
CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY | 2026-02-18 |
| 93 | Real-world, International, Multicentre, Non-interventional, Prospective Cohort to Assess Clinical and Patient-reported Outcomes in Adults With Moderate to Severe COPD Treated With Breztri/Trixeo in Routine Care Settings PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease is a leading cause of global morbidity and mortality, especially in low- and middle-income countries. Exacerbations accelerate disease progression and increase the risk of death. Recent recommendations from the GOLD report emphasize the diagnosis of COPD and treatment planning based on a combination of lung function metrics, exacerbation history, and patient-reported symptoms. It is recommending the use of triple combination therapy (ICS+LABA+LAMA) such as BREZTRI/TRIXEO as one of the options in Group E patients. While BGF has demonstrated efficacy in controlled clinical trials, … |
ASTRAZENECA | 2026-03-17 |
| 94 | The Effect of Bedside Whiteboard Use on Anxiety, Depression and Nursing Care in Chronic Obstructive Pulmonary Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: ABSTRACT Chronic obstructive pulmonary disease (COPD) is a disease characterized by the inability of the body to adequately exchange gases, resulting in progressive shortness of breath that can form secretions and compromise the performance of daily activities. COPD is reported as the third most common cause of death worldwide, with 3.23 million deaths in 2019. Anxiety and depression are common in individuals with COPD. However, COPD is more common in patients with other chronic diseases such as hypertension, diabetes, … |
RAMAZAN DENİZ; | 2025-10-01 |
| 95 | Canadian Consortium for Understanding The Role of Airway Mucus Occlusions in Asthma, COPD and Chronic Cough PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic lung diseases affect one in five Canadians, causing symptoms such as cough, breathlessness, and wheeze. Despite advancements in medical care, these conditions not only impact individuals and their close circles but also present substantial clinical and economic challenges at a national level. This grant is dedicated to addressing three prevalent lung diseases: asthma, chronic obstructive pulmonary disease (COPD), and chronic cough. An alliance of clinicians, scientists, knowledge users, and patient partners from across Canada have come together to establish the Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD, and Chronic Cough – … |
MCMASTER UNIVERSITY | 2026-01-07 |
| 96 | HOLLYWOOD: Hemodynamic Evaluation and Management of Pulmonary Hypertension With Inhaled Iloprost in Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Study Title: A Clinical Study of Inhaled Iloprost for the Treatment of Pulmonary Hypertension in Patients With Chronic Obstructive Pulmonary Disease (HOLLYWOOD) The goal of this clinical study is to learn if the inhaled drug iloprost is effective and safe for treating pulmonary hypertension (PH) in adult patients who have severe or very severe Chronic Obstructive Pulmonary Disease (COPD). The main questions it aims to answer are: Does inhaled iloprost reduce the pressure and resistance in the lung’s blood vessels (measured as Pulmonary Vascular Resistance – PVR)? Does inhaled iloprost improve participants’ ability to exercise, … |
UNIVERSITY OF SAO PAULO GENERAL HOSPITAL | 2025-12-04 |
| 97 | Role of Nocturnal Hypoventilation in Predicting The Long-Term Ventilatory Response in Hypercapnic COPD Patients Treated With Non-Invasive Ventilation: A Prospective Observational Study With Clinical, Functional, and Radiological Assessment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study is an observational, single-center, prospective cohort study aiming to evaluate respiratory mechanics data, as well as clinical and functional parameters commonly used in clinical practice in patients with COPD and hypercapnic respiratory failure. The study population consists of patients with COPD and hypercapnia requiring NIV. The primary objective of the study is to evaluate the association between the reduction in partial pressure of carbon dioxide in arterial blood (PaCO₂) levels at 6 and 12 months after initiating non-invasive ventilation (NIV) and the presence of nocturnal hypoventilation detected at baseline in patients with COPD and chronic hypercapnia. Secondary objectives of this study are the evaluation of the following parameters measured at baseline and/or after 6 and 12 months of NIV treatment in patients with COPD and chronic hypercapnia: * Magnitude of esophageal pressure swing during nocturnal monitoring. * Diaphragm thickness and diaphragmatic thickening fraction assessed by thoracic ultrasound. * Presence of overlap syndrome (COPD + OSA). * Radiological classification of COPD subtypes to assess the association between radiological findings, functional profile, severity of nocturnal hypoventilation, and patterns of chronic hypercapnia. * Respiratory functional parameters, including FEV₁, FVC, FEV₁/FVC ratio, carbon monoxide diffusion capacity (DLCO), and airway resistance (R5 and R20). * Frequency of severe exacerbations and subsequent rehospitalizations during follow-up. * Rate of compliance with respiratory treatment. |
IRCCS AZIENDA OSPEDALIERO UNIVERSITARIA DI BOLOGNA | 2026-02-17 |
| 98 | Utility of Remote Lung Auscultation in COPD With RESP™ Biosensor PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Strados Labs has developed the Strados™ Respiratory Care Platform, including the RESP™ Biosensor System, which encompasses a clinically validated wearable, non-invasive, Bluetooth-enabled device capable of remotely collecting respiratory data. RESP was designed to extend both the geographical and temporal range of lung sound recordings, … |
STRADOS LABS | 2026-01-20 |
| 99 | Effects of Combined Posture Correction Exercise and Resistive Respiratory Muscle Training on Dyspnea, Chest Expansion, Craniovertebral Angle and Pulmonary Function Test, in COPD Patients With Forward Head Posture PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation, often exacerbated by postural abnormalities such as forward head posture (FHP). FHP can lead to significant alterations in breathing patterns, reducing the efficiency of respiratory muscles and impairing lung function. Patients with COPD and FHP frequently exhibit muscular imbalances, where overactive accessory muscles compensate for weakened primary respiratory muscles Resistive Inspiratory Muscle Training strengthens inhalation muscles using resistance devices to enhance respiratory function in COPD patients. Resistive Expiratory Muscle Training focuses on strengthening exhalation muscles through resistance during exhalation, … |
WAJEEHA ZIA; | 2026-01-05 |
| 100 | Bridging The Gap Between Prescription and Practice: Impact of Nurse-Led Inhaler Education on Patient Technique, Knowledge, Adherence, and Beliefs – A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma and chronic obstructive pulmonary disease (COPD) are among the most prevalent chronic respiratory conditions worldwide, affecting hundreds of millions of individuals and contributing substantially to morbidity, mortality, and healthcare burden. Although clinicians routinely advise patients verbally on inhaler use, the lack of structured, hands-on education results in significant variation in technique and consistently poor retention of skills over time. |
MOHAMED ABD ELMONIEM MOHAMED; | 2026-03-02 |
| 101 | Changing Outcomes Through Achievement Emails in COPD Using Routine Healthcare Audits PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is exploring how to improve prescribing for people with chronic obstructive pulmonary disease (COPD) in primary care. COPD is a long-term lung condition. Guidelines recommend the most effective inhalers for different patient groups, but in practice, some patients still receive treatments that are less effective or no longer recommended. One proven way to support better prescribing is audit and feedback. This involves giving GP practices reports showing how their prescribing compares with guidance and with other practices. Audit and feedback can change behaviour, particularly when focused on medicines and when practices have scope to improve. In West Yorkshire, … |
OWEN THOMAS; | 2026-01-15 |
| 102 | Unveiling The Fungal Frontier: Characterizing Diversity and Antifungal Resistance in Immunocompromised ICU Patients With Respiratory Tract Infections PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Immunocompromised individuals face a heightened risk of life-threatening fungal infections, which arise from a multitude of environmental and commensal fungi. Surveillance data from ICUs worldwide identifies Candida spp. as the dominant foe, responsible for 80% of such infections, earning it the dubious distinction of being the third most prevalent pathogen. While C. albicans holds the dubious crown as the most common Candida offender, recent years have witnessed a concerning trend toward non-Albicans candida, raising concerns about potential antifungal resistance. |
ASMAA NADY HUSSEIN; | 2025-08-14 |
| 103 | MOBoxy: MoblO2 to Maintain Oxygenation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course. Practitioners prescribe O2 to patients with chronic lung disease in hopes of the following: 1) that it will limit desaturation events and combat breathlessness, thus preventing the frustratingly slow pace and numerous rest breaks patients are forced to adopt while doing even simple tasks; 2) that it will allow patients to be more active physically (perhaps increase their ability to exercise) and socially (perhaps leave the home more often); … |
JEFF SWIGRIS; | 2025-10-30 |
| 104 | Chronic Obstructive Pulmonary Disease, Quality of Life, COPD Assessment Test, Nepal, Dyspnea, Spirometry PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. The study Quality of life among people living with Chronic Obstructive Pulmonary Disease- visiting spirometry center of Tribhuvan University Teaching Hospital, Kathmandu Nepal aims to assess the quality of life (QOL) of COPD patients and the factors affecting it. A cross sectional study will be performed among the patients visiting Spirometry center of Tribhuvan University Teaching Hospital, … |
ABHISHEK KUMAR SHAH; | 2025-12-03 |
| 105 | Clinical Study on The Safety, Tolerance and Preliminary Efficacy of Human Mesenchymal Stem Cell Therapy for Parkinson’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study, through different administration methods, adopted a randomized, double-blind, placebo-controlled trial design to evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells (hUC-MSCs) in patients with Parkinson’s disease, explore their initial effectiveness and the relationship between biological active factors and therapeutic efficacy. The Clinical Study on the Treatment of Parkinson’s Disease with Human Umbilical Cord Mesenchymal Stem Cells of this study is expected to provide clinical trial evidence for the development of safe and effective clinical cell therapies for patients with Parkinson’s disease. |
LIAONING MEDICAL DIAGNOSIS AND TREATMENT TECHNOLOGY RESEARCH AND DEVELOPMENT | 2025-11-18 |
| 106 | Serum Surfactant Protein-D and Inflammatory Biomarkers As Predictors of Disease Severity in Hospitalized Chronic Obstructive Pulmonary Disease (COPD) Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: evaluation of the serum levels of surfactant protein-D (SP-D), C-reactive protein (CRP), fibrinogen, and peripheral blood neutrophilic and eosinophilic counts in patients with COPD correlation of these biomarkers with clinical, functional, and radiological parameters |
ASMAA MOSTAFA AHMED MOHAMED; | 2025-09-10 |
| 107 | Development And Evaluation of An Adaptive Web-Based Intervention for Whole Health Support For Patients With Chronic Pulmonology Obstructive Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Narrative-based tiered asynchronous psychosocial and behavioral whole health support for people adjusting to living with COPD. The intervention is administered by experienced LCSWs under the PI’s supervision. |
UNIVERSITY OF COLORADO DENVER | 2025-05-08 |
| 108 | Effects of Blood Flow Restriction Aerobic Exercise on Systemic Inflammation, Hypoxia, Exercise Capacity, and Pulmonary Functions in Patients With Chronic Obstructive Pulmonary Disease: A Prospective Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose: This study aims to compare the effects of the classical pulmonary rehabilitation (PR) program and blood flow restriction (BFR) applied during low-intensity aerobic exercise within PR on systemic inflammation, hypoxemia, exercise capacity, pulmonary function, respiratory muscle strength, and quality-of-life parameters in individuals with COPD. Methods: This randomized controlled study will include 34 individuals with COPD, allocated into a BFR aerobic group and a control group. Both groups will receive core PR components, including diaphragmatic breathing, pursed-lip breathing, respiratory muscle training, and peripheral muscle strengthening. The BFR group will perform low-intensity aerobic exercise with blood flow restriction, … |
ISTINYE UNIVERSITY | 2025-12-10 |
| 109 | Clinical and DEmographic ChaRacteristics of Patients With Frequent COPD Exacerbations and Evaluation of Therapeutic Approaches in Treatment in Moscow PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This Study is multicenter, non-interventional, ambispective registry to evaluate the demographic and clinical characteristics, therapeutic approaches and outcomes in COPD outpatients with frequent exacerbations in Moscow |
ASTRAZENECA | 2026-03-16 |
| 110 | A Randomised, Double-blind, Multi-centre, Placebo-controlled, Crossover Study to Assess The Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler on Cardiac and Lung Function in Participants With Chronic Obstructive Pulmonary Disease and Hyperinflation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to evaluate the effect of BGF MDI compared with placebo MDI on cardiac and lung function when administered in participants diagnosed with COPD and hyperinflation. |
ASTRAZENECA | 2026-03-19 |
| 111 | Pulmonary Overdistension Assessment With Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrom in Prone Position PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Mechanical ventilation in COPD requires a good interaction Patient-Ventilator without asynchronies in order to reduce mortality. Dynamic hyperinflation with PEEPi is responsible for major asynchronies in COPD. It is supposed to be symmetrical between the 2 lungs with the same PEEPi. EIT can measure the distribution of tidal ventilation and interlung lung insufflation delay on the impedance time curve of each lung. Moreover, it is possible in intubated COPD patients to assess one lung PEEPi during low flow insufflation with pressure-EIT monitoring. This study aims to measure interlungs insufflation delay under mechanical ventilation in COPD patients |
LABARRERE SÉVERINE; | 2025-12-03 |
| 112 | A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical Practice PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study will explore how Wegovy® (Semaglutide) is used in everyday situations, how it might affect things like weight, body mass index (BMI) and waist circumference, and what kind of impact it could have on overall quality of life. The overall purpose of this study is to understand how Wegovy impacts weight when used as part of regular medical care. Participants will be treated with Wegovy as prescribed to the participant by their doctor, in accordance with normal clinical practice. The study will last for about two years. |
NOVO NORDISK | 2026-03-05 |
| 113 | Improvement of Adherence to Treatment Among COPD Patients in Primary Care By Physician-directed Intervention PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether a special training program for primary care doctors can help improve treatment adherence and overall outcomes for people with chronic obstructive pulmonary disease (COPD). The main questions it aims to answer are: * Does the training program help patients with COPD take their medications more regularly? * Does it reduce the number of COPD flare-ups (exacerbations)? * Does it improve how well doctors follow current treatment guidelines for COPD? In this study: * Primary care doctors will be randomly assigned to either receive the training or continue their usual care without intervention. * The training includes updated information about COPD, a workshop on inhaler use, and a course on motivational interviewing (a method to support behavior change) * The care of their patients with COPD will be reviewed over 12 months to see if the program made a difference in medication use, flare-ups, and other outcomes. |
TEL AVIV SOURASKY MEDICAL CENTER | 2026-03-05 |
| 114 | Investigation of The Acute Effects of Traditional and Functional Inspiratory Muscle Training on Muscle Oxygenation in Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the effects of functional and conventional inspiratory muscle training (IMT) on post-exercise muscle deoxygenation in individuals with Chronic Obstructive Pulmonary Disease (COPD). Participants will complete both training modalities on separate days. A 2-minute walk test (2MWT) will be performed baseline, and after each session. Muscle oxygenation (SmO₂) will be assessed using near-infrared spectroscopy . Dyspnea and fatigue will be evaluated with the Modified Borg Scale, and heart rate and oxygen saturation (SpO₂) will be measured by pulse oximetry. Measurements will be recorded before, after training and at the end of the walking test. |
SAGLIK BILIMLERI UNIVERSITESI | 2025-12-05 |
| 115 | A Phase IIa, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy, Safety and Pharmacokinetic Characteristics of JKN2403 Tablets in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if drug JKN2403 works to treat moderate-to-severe COPD in adults. It will also learn about the safety and pharmacokinetic characteristics of drug JKN2403. The main questions it aims to answer are: Does drug JKN2403 reduce the incidence of AECOPD or improve the quality of life or alleviate symptoms related to COPD? Researchers will compare drug JKN2403 to a placebo (a look-alike substance that contains no drug) to see if drug JKN2403 works to treat moderate-to-severe COPD. Participants will: Take drug JKN2403 or a placebo every day for 24 weeks Visit the clinic once every four weeks for checkups and tests Keep a diary of their symptoms and the number of times they use a rescue inhaler |
JOINCARE PHARMACEUTICAL GROUP INDUSTRY | 2026-01-20 |
| 116 | Nasal High Flow in Early Management of Patients Admitted to The Emergency Department for Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis : A Randomized Controlled Non Inferiority Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and hypercapnic acidosis in the emergency department (ED). After obtaining informed consent, participants will be randomly assigned to receive either nasal high flow or non invasive ventilation (NIV, reference treatment) as respiratory support. Researchers will compare both respiratory support groups to see if their blood gas analysis and respiration return to normal ranges. |
MUSTAPHA SEBBANE; | 2025-07-08 |
| 117 | Evaluating The Efficacy and Safety of Modified Qing-Zao-Jiu-Fei Decoction on Pneumoconiosis Patients: A Randomized, Double-blinded, Placebo-Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, double-blind, placebo-controlled study to investigate the beneficial efficacy and safety of Chinese medicine formula Modified Qing Zao Jiu Fei Decoction (MQZJFD) on pneumoconiosis patients. Participants will be randomized into one of the two groups (MQZJFD treatment group or placebo control group), … |
XIAN YANFANG; | 2025-09-17 |
| 118 | Feasibility, Adoption and Efficacy of Digital Inhaler in The Management of Obstructive Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a pilot study to evaluate the role digital inhaler technology on patients with obstructive lung disease in preventing admissions and exacerbation, as well as improving symptom control. The primary objective is to evaluate feasibility of study protocol, patient recruitment, and patient retention with goal recruitment of 20 participants, 60% recruitment success, and 60% retention rate for 6 months duration. The secondary objectives are the evaluation of patient admission rate, exacerbation rates, and symptoms control with use of digital inhaler technology The subject population will be patients with physician diagnosed obstructive lung disease. |
SARA GHANDEHARI; | 2025-10-09 |
| 119 | Study of High-velocity Nasal Insufflation Versus Non-invasive Positive Pressure Ventilation for Emergency Type 2 Respiratory Failure: A Non-inferiority Randomized Controlled Trial (The SHINE Trial) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if high velocity nasal insufflation (HVNI) is comparable to non-invasive positive pressure ventilation (NIPPV) in treatment of emergency patients with acute respiratory acidosis. In our non-inferiority trial, … |
MUI TENG CHUA; | 2025-07-15 |
| 120 | Exacerbations and Real-World Outcomes Among Patients With Chronic Obstructive Pulmonary Disease Following Severe Exacerbation (MITOS:EROS+DISCHARGE) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This real-world retrospective study will use de-identified administrative claims data and will examine patients with a diagnosis of COPD who have experienced a qualifying severe disease exacerbation and received subsequent treatment with BGF. Agreed COPD patient data from the Inovalon MORE2 Registry® and Centers for Medicare \& Medicaid Services (CMS) 100% Medicare Fee for Service (FFS) database spanning from January 1, 2021 to the most recently available data (September 30th, 2024 for the MORE2 database, and December 31st, … |
ASTRAZENECA | 2026-02-17 |
| 121 | The Use of Diaphragmatic Ultrasonography: Does It Change Mechanical Ventilation Weaning Decision and Predict Outcome in COPD Patient? PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the use of diaphragmatic ultrasonography in taking mechanical ventilation weaning decision and predicting outcome in Chronic obstructive pulmonary disease patient. Primary outcome: • Number of patients with failed weaning trial and need reintubation. Secondary outcomes: * Time till extubation trial. * Ventilation free days after extubation less or more than 48h . * Number of Intensive care unit discharges. * Sensitivity and specificity of diaphragmatic assessment as a predictor of weaning. |
SHIMAA ADEL MOHAMED HELMY BADR; | 2025-07-24 |
| 122 | Impact of Airway Mucus Plugs on Secondary Pulmonary Fibrosis in COPD Patients: A Single-Center Case-Control Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is frequently accompanied by airway mucus plugs, which are closely associated with airflow obstruction, acute exacerbations, and increased mortality. However, whether mucus plugs contribute to secondary pulmonary fibrosis remains unclear. This single-center, prospective, case-control study aims to investigate the relationship between airway mucus plugs and lung fibrosis in patients with COPD undergoing lung cancer surgery. During surgery, distal non-tumorous lung tissues and airway mucus will be collected for histological and molecular analyses. Mucus plug burden will be quantified using AB-PAS staining, and fibrosis will be assessed using Masson staining. Expression of epithelial-mesenchymal transition (EMT) markers, … |
MING ZHONG; | 2025-11-19 |
| 123 | The Effect of The High-intensity Resistance Training in COPD Patients Recovering From Hospital Exacerbation: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery. Traditional respiratory rehabilitation usually focuses on endurance training, which is effective but often hard to tolerate soon after an exacerbation due to persistent symptoms and limited functional capacity. This study aims to compare two early rehabilitation approaches during recovery from a COPD exacerbation: a maximal strength training (MST) programme using high loads and few repetitions, and a traditional endurance-based training programme. The investigators aim to determine whether MST is easier to tolerate, … |
ISTITUTI CLINICI SCIENTIFICI MAUGERI SPA | 2025-12-24 |
| 124 | Continuous Cough Monitoring for Early Detection of COPD Exacerbations Using Hyfe PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is for adults with COPD. Flare-ups of COPD, also known as exacerbations, can be serious and lead to hospital stays. The purpose of this research is to see if continuously and automatically monitoring a person’s coughs can help predict these flare-ups early, before they become severe. Participants will use the Hyfe cough monitoring system, which includes a watch-like device worn on the wrist and a smartphone application. The system privately counts the number of coughs without recording any audio. Participants will also answer a short, weekly questionnaire about their COPD symptoms. This is an observational study, … |
CLINICA UNIVERSIDAD DE NAVARRA UNIVERSIDAD DE NAVARRA | 2026-01-02 |
| 125 | A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Study of The Efficacy and Safety of Early Depemokimab Initiation As Add-on Treatment in COPD Patients With Type 2 Inflammation PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Depemokimab is being developed as a treatment for individuals with moderate to severe Chronic Obstructive Pulmonary Disorder (COPD). The aim of this study is to assess the efficacy and safety of early initiation of depemokimab as an add-on medicine in participants with moderate to severe COPD with type 2 inflammation. |
FELIPE GASCON-RODON; | 2025-11-25 |
| 126 | The Effects of Biphasic Positive Airway Pressure (BIPAP) Use on Diaphragm Functions in Patients With Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research is designed to evaluate how long-term treatment with Bilevel Positive Airway Pressure (BiPAP) influences diaphragm function in patients with Chronic Obstructive Pulmonary Disease (COPD) who suffer from chronic hypercapnic respiratory failure. The diaphragm is the primary muscle of breathing, and its dysfunction is linked to unfavorable clinical outcomes such as higher mortality rates and frequent hospitalizations. In this prospective cohort study, COPD patients starting BiPAP therapy based on clinical indication will be monitored through repeated ultrasound assessments of diaphragm structure and function together with pulmonary function testing, respiratory muscle strength evaluation, … |
REYHAN KAYGUSUZ; | 2025-09-25 |
| 127 | Ultrasound of The Diaphragm Excursion Ratio As Physiological Biomarker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 3.1 Introduction and rationale In 2020 an estimate of 562.700 people had Chronic Obstructive Pulmonary Disease (COPD) in the Netherlands, resulting in 21.335 hospital admissions.\[1\] An acute exacerbation COPD (AECOPD) in combination with hospital admission is associated with high mortality and morbidity. \[2\] Noninvasive ventilation (NIV) has been very effective in the context of AECOPD, since it efficiently offloads respiratory muscles and counteracts dynamic hyperinflation. This method often prevents intubation as a bridge to administering effective therapies (e.g., glucocorticoids, bronchodilators, and antibiotic agents)\[3\], … |
WYTZE DE BOER; | 2025-12-02 |
| 128 | Implementation of A Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Sarcopenia, or skeletal muscle loss, impacts up to 40% of COPD patients and is a major cause for morbidity and mortality. Despite the high clinical significance of sarcopenia in COPD, the diagnosis remains elusive because accurate measures of skeletal muscle are not tested during routine clinical care. The goal is to use evidence-based strategies to diagnose and treat sarcopenia due to COPD. The multidisciplinary team includes a pulmonologist, pharmacist, COPD nurse, … |
AMY ATTAWAY; | 2025-10-30 |
| 129 | Inhaler Trainer Efficacy Study: Interactive Training Tool Providing Technique Feedback for COPD/Asthma Medication Delivery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This will be a randomized, controlled, clinical trial. The investigators aim to determine the feasibility of and efficacy of the Inhaler Trainer Device for ongoing inhaler skill training. The research team will enroll 140 patients from the inpatient or outpatient setting from the University of Chicago Medicine over the course of up to 12 months. Participants will complete assessments, a lung function test via spirometry, and inhaler education via either the Inhaler Trainer Device learning program or Brief Intervention. All participants will return at 6 weeks (window of +/- … |
KORONIS BIOMEDICAL TECHNOLOGIES | 2025-10-14 |
| 130 | Laying The Foundation for Building A Resilient KPNC Community in The Face of Worsening Air Quality Due to Wildfire Smoke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The overarching goal of this project is to conduct a pilot intervention in high-risk Kaiser Permanente Northern California patients with chronic obstructive pulmonary disease to mitigate their exposure to poor air quality and decrease exacerbations of lung disease. |
LAURA MYERS; | 2025-11-20 |
| 131 | A Phase II, Randomized, Double-Blind, Cross-Over Study to Assess The Pharmacokinetics, Pharmacodynamics, and Safety of Single Inhaled Doses of Ensifentrine-Glycopyrrolate Fixed Dose Combination, Ensifentrine, and Glycopyrrolate in Subjects With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will assess the pharmacokinetics (PK), pharmacodynamics (PD) and safety of ensifentrine and glycopyrrolate fixed dose (FDC) product, the individual components of the FDC (ensifentrine and glycopyrrolate, each in the FDC formulation), ensifentrine 1.5 mg in the FDC formulation and ensifentrine 3 mg in the marketed formulation each administered via a standard jet nebulizer, in adult participants with chronic obstructive pulmonary disease (COPD). |
VERONA PHARMA PLC | 2026-01-08 |
| 132 | Comparison of Respiratory and Peripheral Muscle Strength, Exercise Capacity, and Muscle Oxygenation in Individuals With COPD and PRISM PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: COPD is a preventable and treatable lung disease characterized by persistent and progressive airflow limitation. PRISm, on the other hand, is a spirometry pattern that does not meet COPD diagnostic criteria despite symptoms and functional impairments, but requires maintenance. PRISm can predispose to the development of COPD and exacerbations, and can reduce exercise capacity by reducing respiratory function and oxygen consumption. There are no studies in the literature comparing respiratory muscle strength, peripheral muscle strength, and oxygenation in PRISm, COPD, and healthy individuals. Therefore, this study aimed to evaluate these parameters and compare them with healthy individuals. |
MUSA GÜNEŞ; | 2025-11-25 |
| 133 | Effectiveness and Cost-effectiveness of An Integrated Digital Psychological Intervention (EmoEase) in Chinese COPD Patients: Study Protocol of A Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Background Mental health issues are common and often overlooked in COPD patients. Digital psychological interventions might help, but their effectiveness in Chinese COPD patients hasn’t been studied. This study aims to develop and evaluate EmoEase, a digital psychological intervention, for its effectiveness and cost-effectiveness in improving mental wellbeing in Chinese COPD patients. Methods This multicenter, two-arm, randomized controlled trial (RCT) will enroll at least 420 COPD patients over 35 years old. Participants will receive either usual care (control group) or usual care plus EmoEase (intervention group). Assessments will occur at baseline (T0), 4 weeks (T1), 8 weeks (T2), … |
SIMIAO CHEN; | 2025-08-13 |
| 134 | Assessment of The Importance of Respiratory Stabilization in Patients With Chronic Respiratory Acidosis Before A Diagnostic Bronchofiberoscopy, As Well As The Effectiveness of Different Types of Non-invasive Ventilation During The Procedure PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes. FOB frequently impairs respiratory function, which may lead to possible exacerbation of respiratory failure. Currently, the most frequent respiratory support is passive oxygen therapy, but non-invasive ventilation (NIV) and high flow nasal cannula (HFNC) are increasingly attempted, however the optimal setting and indications for NIV and HFNC in patients undergoing FOB with respiratory acidosis, haven’t been determined yet. Methods: The study protocol describes a prospective, multicenter, two- armed randomized controlled trial (RCT). The investigators aim to study two patients groups, … |
SZYMON SKOCZYŃSKI; | 2025-05-14 |
| 135 | Effectiveness of A Motivational Interviewing Program on The Self-Care Levels of Patients With Idiopathic Pulmonary Fibrosis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A specific tool developed to measure self-care in patients with Idiopathic Pulmonary Fibrosis (IPF) is the SC-IPFI, which is an adaptation of an already validated instrument for COPD. It is important to assess how motivational interviewing can influence the self-care behaviors of these patients, better evaluate their level of disease management, prevent the risk of exacerbations, and guide educational interventions. The primary objective of this study is to evaluate the effectiveness of a motivational interviewing program delivered remotely through video calls and digital platforms in improving the levels of self-care maintenance, self-care monitoring, … |
RICHELDI LUCA; | 2025-09-18 |
| 136 | A Two-center, Randomized, Double-blind, Placebo-controlled Study of Intravenous Plasma-purified Alpha-1 Antitrypsin for Hospitalized Patients With COPD Exacerbations (AECOPD Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Intravenous augmentation therapy with purified preparations of AAT (Alpha1-antitrypsin) derived from human plasma is a well consolidated specific therapeutic option to treat the severe deficient state of AAT. Prolastin is used to restore the balance between AAT and elastases in the lung and consequently to prevent a further deterioration in the pulmonary emphysema. Recently, in patients with COVID-19, without genetically lowered AAT levels with moderate to severe ARDS, treatment with AAT was demonstrated to be safe, feasible, and biochemically efficacious as an anti-inflammatory therapeutic therapy. The aim of the study, based on biological plausibility, … |
ANGELO GUIDO CORSICO; | 2025-08-15 |
| 137 | Evaluation of The Paramedic Evaluation for Acute COPD Exacerbation (PEACE) Intervention PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a serious lung condition that affects millions of people in the United States. Each year, it leads to about 150,000 deaths, nearly 900,000 emergency room visits, and 700,000 hospital stays. When COPD symptoms suddenly get worse-called an exacerbation-it can seriously harm a person’s quality of life and often requires emergency care. Treating these flare-ups early can help prevent hospital visits, but right now, there aren’t many good ways to make sure people get care quickly. Mobile Integrated Health (MIH) programs send specially trained paramedics, guided remotely by doctors, … |
LAUREL O’CONNOR; | 2025-11-26 |
| 138 | Comprehensive Maintenance Program: A Health Haven for COPD in Lleida.The NAPOLEON Project PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: Pulmonary rehabilitation programs (PRPs) are known to reduce symptoms such as dyspnea and fatigue, while improving functional capacity and quality of life in individuals with chronic obstructive pulmonary disease (COPD). However, the benefits of an initial pulmonary rehabilitation program (PRP) tend to diminish rapidly over time, prompting the development of strategies to maintain these effects. Such strategies include supervised exercise programs, telephone follow-ups, and home-based exercise regimens. Nevertheless, the optimal maintenance strategy remains uncertain. Objectives: The primary objective is to evaluate the impact of a supervised, … |
JESSICA GONZÁLEZ GUTIÉRREZ; | 2026-02-06 |
| 139 | Comparison of The Effects of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Peripheral and Respiratory Muscle Oxygenation, Pulmonary Function, Exercise Capacity, and Peripheral Muscle Strength in Individuals With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a progressive condition marked by airflow limitation and chronic inflammation, leading to reduced exercise capacity, peripheral muscle dysfunction, and dyspnea. High-Intensity Interval Training (HIIT) may offer a promising alternative for patients with low exercise tolerance; however, evidence on its effectiveness remains limited. This study aims to compare the effects of HIIT and Moderate-Intensity Continuous Training (MICT) on muscle oxygenation, pulmonary function, exercise capacity, and peripheral muscle strength in individuals with COPD. Participants will undergo an 8-week exercise program, twice weekly. HIIT will consist of 1-minute intervals at 90% and 30-40% of peak workload, … |
AYNUR DEMIREL; | 2025-08-07 |
| 140 | Effect of Exercise Ventilatory Support Pressure on Endurance in Patients With Severe Chronic Obstructive Pulmonary Disease – AVE-BPCO PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by progressive obstruction of the airways. In advanced stages, it can progress to chronic respiratory failure with major respiratory repercussions. Biologically, hyperinflation manifests as alveolar hypoventilation, which causes hypercapnia. Mechanically, it is responsible for an increase in ventilatory work associated with diaphragmatic muscle dysfunction and fatigue, … |
FRÉDÉRIC ROCHE; | 2025-08-15 |
| 141 | Effectiveness of Hypnosis on Breathlessness Mastery in Patients With Persistent Dyspnea: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Persistent dyspnea is a debilitating symptom, that is common and difficult to treat. This symptom is found in many different diseases including chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), chronic heart failure (CHF), and metastatic cancer. Dyspnea is associated with many other symptoms, including anxiety, depression, and fatigue and is responsible for a significant reduction in quality of life. To date, … |
LISA HENTSCH; | 2025-09-15 |
| 142 | A Bidirectional Cohort Study of Single-Cell Sequencing and Single-Cell Spatial Transcriptomics in Chronic COPD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is an ambispective cohort study, the sample from patients were from both previously stored and freshly collected . The objective of this study is to investigate the molecular pathological changes underlying the development of chronic obstructive pulmonary disease (COPD). We will use single cell sequencing technology to analyze lung tissue samples from patients who underwent lung resection, with lung tissue from patients without COPD serving as controls. This research aims to provide insights into the pathogenesis of COPD. |
FANG CHEN; | 2025-10-06 |
| 143 | Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether inhaled Treprostinil (Tyvaso) can improve oxygen delivery and blood flow in the lungs in adults (age ≥40) with chronic obstructive pulmonary disease (COPD) and hypoxemia who have less severe reduction in lung blood volume (diffusing capacity of the lungs for carbon monoxide \[DLCO\] ≥45%). The main questions it aims to answer are: 1. Does inhaled Treprostinil increase pulmonary capillary blood volume in ventilated lung regions, … |
BASTIAAN DRIEHUYS; | 2025-10-30 |
| 144 | Examining The Role of Functional Social Support Subtypes for Self-Management Capacity Among Individuals With COPD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims to examine how different types of functional social support (emotional/informational, tangible, affectionate, and positive social interaction) predict self-management capacity among individuals with chronic obstructive pulmonary disease (COPD). The study includes a quantitative cross-sectional survey and qualitative semi-structured interviews (N=20) to explore barriers and facilitators to adequate social support. Findings will inform the development of targeted self-management interventions for COPD patients. |
EMILY MORGAN; | 2026-01-20 |
| 145 | A Randomized, Double-blind, Placebo-controlled Study to Evaluate The Effect of Dupilumab on Airway Inflammation Through Assessments of Mucus Plugging and Other Lung Imaging Parameters in Patients With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: LPS18583 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 4 study with 2 treatment groups. The purpose of this study is to assess the effect of dupilumab compared with placebo on airway inflammation, resistance, and remodeling including mucus plugging and its association with improvement on lung function, exacerbations, and quality of life improvement in participants aged 40 years of age up to 85 years of age (inclusive). Study details include: The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The number of visits will be 9. |
SANOFI | 2026-03-24 |
| 146 | Comparison of Exercise Capacity, Muscle Strength and Oxygenation, Arterial Stiffness, Physical Activity and Quality of Life in Individuals With Chronic Obstructive Pulmonary Disease and Impaired Spirometry With Preserved Ratio PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Despite the globally varying high prevalence rate of the PRISm phenotype, there are no guidelines for its diagnostic evaluation and management. Further studies are needed on appropriate approaches for individuals with PRISm to improve respiratory symptoms and prognosis. As research continues to evolve, PRISm needs to be recognized as a critical component of pulmonary assessments and at-risk individuals need to be provided with appropriate treatment and follow-up to prevent progression to COPD. There are no studies in the literature comparing PRISm, respiratory muscle strength, peripheral muscle strength and oxygenation, arterial stiffness, … |
ECE KUMLU; | 2026-03-31 |
| 147 | A Phase 2b/Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study, to Investigate The Efficacy and Safety of Lunsekimig in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized By An Eosinophilic Phenotype PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COPD) characterized by an eosinophilic phenotype. Participation to the study consists of 3 periods: * Screening period of up to 4 weeks * Randomized intervention period of approximately 48 weeks * Follow-up period: Approximately 8 weeks The study duration will be up to 60 weeks. |
SANOFI | 2026-03-23 |
| 148 | A Phase 2b/Phase 3, Randomized, Double-blind, Placebocontrolled, Multicenter Study, to Investigate The Efficacy and Safety of Lunsekimig in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized By An Eosinophilic Phenotype PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a parallel, Phase 2b/Phase 3, 3-arm study to investigate the efficacy, safety, and tolerability of subcutaneous (SC) treatment with lunsekimig compared with placebo in adult participants (aged 40 to 80 years, inclusive) with inadequately controlled Chronic obstructive pulmonary disease (COPD) characterized by an eosinophilic phenotype. Participation to the study consists of 3 periods: * Screening period of up to 4 weeks * Randomized intervention period of approximately 48 weeks * Follow-up period: Approximately 8 weeks The study duration will be up to 60 weeks. |
SANOFI | 2026-03-23 |
| 149 | An International Survey on The Use of NIV Outside The ICU (NIV-Safety Study) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Non-invasive ventilation (NIV) is a way to support breathing using a mask or helmet instead of a breathing tube, and it is proven to reduce the need for intubation, save lives, shorten hospital stays, and lower costs. While NIV has long been used in intensive care units, it is now increasingly applied in emergency rooms, hospital wards, and long-term care facilities. However, global data on how it is used outside ICUs-such as which patients receive it, how well it works, and what barriers exist-is lacking. The NIV-Safety Study is a worldwide survey of doctors, nurses, … |
SANJAY SINGHAL; | 2025-09-30 |
| 150 | Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia. The exposure to atmospheric pollutants will be assessed simultaneously in a group of healthy volunteers. The ultimate goal of the study is to enhance the understanding of the mechanisms by which atmospheric pollutants act, in order to develop new tools that can help halt or at least delay the development of diseases associated with pollution. |
STEFANO NAVA; | 2025-12-19 |
| 151 | A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are characterised by lung inflammation and remodelling. Clinical, functional, microbiological, biological, pathological and prognostic features are highly variable and heterogeneous. Several phenotypes have been described within the same pathology, as similar phenotypic traits between different pathologies, or the coexistence of components of several diagnoses in the same patient, suggesting shared underlying mechanisms that could represent new therapeutic targets, beyond the initial medical diagnosis. The objectives of this prospective study are to analyze the phenotypic characteristics (clinical, … |
CHU DE REIMS | 2026-02-20 |
| 152 | Evaluation of The Validity and Reliability of The Londrina Activities of Daily Living Protocol in Patients With Pulmonary Hypertension PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this observational study is to evaluate the validity and reliability of the Londrina Daily Living Activities Protocol in patients diagnosed with pulmonary hypertension (PH). |
PINAR BASTURK MERC; | 2025-11-25 |
| 153 | Pulmonary and Total Blood Volume in COPD: A Prosoective Matched Comparative Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background Patients with chronic obstructive lung disease (COPD) suffer from a progressive loss of lung function that leads to poor quality of life, and often invalidity and early death. This is markedly affected by a reduced exercise capacity and dyspnoea, but the underlying mechanisms are unknown. In the present study, … |
RONAN BERG; | 2026-02-24 |
| 154 | Comparative Effects of Pilates Breathing and Pursed Lip Breathing on Chest Expension and Peak Expiratory Flow Rate in Patients With Chronic Obstructive Lung Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease is a particular type of irreversible disease that may damage or obstruct airways and make it difficult to breath. This respiratiry condition may lead to shallow breathing. Breathing exercisers help to manage hyperventilation often seen in COPD patients. To handle respiratory complications patients are advised to practice breathing techniques along with pharmacological management |
FOUNDATION UNIVERSITY ISLAMABAD | 2025-10-07 |
| 155 | Comparison Between Conventional Rehabilitation and Conventional Rehabilitation Through Dance in Patients With Chronic Obstructive Pulmonary Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: Chronic obstructive pulmonary disease (COPD) is recognized as one of the most relevant conditions worldwide, due to its high morbidity and mortality. Patients classified by GOLD as groups B and E are strongly encouraged to participate in pulmonary rehabilitation (PR) programs. Dance has been shown to be equally or, at times, … |
THAÍS F DE ANDRADE LIMA; | 2025-09-30 |
| 156 | A Randomized, Double-Blind, Placebo-controlled, Single- and Multiple-ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in Healthy Volunteers and Participants With Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a randomized, double-Blind, placebo-controlled, Single- and Multiple-ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in Healthy Volunteers and Participants with Chronic Obstructive Pulmonary Disease (COPD). |
QIAN ZHANG; | 2026-01-07 |
| 157 | The Impact of Nurse Practitioner-Led Multidisciplinary Team Intervention on The Implementation of Guideline-Directed Medical Therapy and Clinical Outcomes in Adults With Multimorbidity: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether a nurse practitioner-led multidisciplinary team (NP-led MDT) intervention can improve the use of guideline-directed medical therapy (GDMT) and short-term clinical outcomes in hospitalized adults with multimorbidity in a multidisciplinary medicine ward. The main questions it aims to answer are: Does NP-led MDT intervention increase the proportion of patients achieving GDMT at hospital discharge? Does NP-led MDT intervention reduce 30-, 60-, and 90-day readmission, emergency department visits, … |
HSIAO-CHEN CHOU NURSE PRACTITIONER; | 2026-03-19 |
| 158 | Rehabilitation Intervention for COPD Combined With Cardiovascular and Cerebrovascular Diseases PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: Firstly, to screen out the high-risk population of COPD combined with cardiovascular and cerebrovascular diseases, COPD with cardiovascular and make a diagnosis. Then, to evaluate the therapeutic effect of Pulmonary rehabilitation exercise and usual care for three months. And finally, to build a trinity model of rehabilitation management of COPD patients. The objective of this project is to establish and promote the application of diagnostic and treatment norms. |
YANG JIN; | 2025-07-29 |
| 159 | Clinical Registry for The Characterization of The ‘Pulmonary Vascular Phenotype’ in Patients With Chronic Obstructive Pulmonary Disease – A Retrospective Multi-center Data Analysis PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Registry of COPD (Chronic Obstructive Pulmonary Disease) patients who underwent right heart catheterization (RHC) and full clinical evaluation for pulmonary hypertension |
GABOR KOVACS; | 2026-01-14 |
| 160 | Evaluation of A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial on The Efficacy and Safety of Inhaled TQC3721 Suspension in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy of TQC3721 Suspension for Inhalation in patients with moderate to severe Chronic obstructive pulmonary disease (COPD) |
CHIA TAI TIANQING PHARMACEUTICAL GROUP | 2025-09-10 |
| 161 | Survey on Non-Invasive Ventilation Settings in The Intensive Care Unit for Acute Exacerbation of Chronic Obstructive Pulmonary Disease PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction Chronic obstructive pulmonary disease (COPD) is a common condition and the fourth leading cause of death worldwide. With the rise of non-invasive ventilation (NIV), mortality among patients admitted for acute hypercapnic respiratory failure has decreased, … |
UNIVERSITY HOSPITAL CAEN | 2025-03-26 |
| 162 | A Clinical Evaluation of The Pulsed Electric Field Ablation System for The Treatment of The Symptoms of Chronic Bronchitis in Adult Patients With COPD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, randomized, parallel group, sham-controlled, multicenter clinical trial. The objective is to evaluate the safety and effectiveness of pulsed electric field ablation system manufactured by Suzhou Hengruihongyuan Medical Technology Co., Ltd. for the treatment of the symptoms of chronic bronchitis in adult COPD patients with moderate to severe chronic bronchitis. A total of 210 patients will be randomized into the experimental group and the sham group (2:1). |
LING XU; | 2025-09-02 |
| 163 | Evaluating Care Pathways for Chronic Respiratory Diseases in Brazil PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators aim to investigate how individuals attending primary healthcare (PHC) services in Brazil for treatment of non-communicable diseases (NCDs), identified there as having abnormal spirometry or as being at high risk for lung health problems (such as asthma and chronic obstructive pulmonary disease-COPD, collectively referred to as chronic respiratory disease (CRDs)) using the COLA-6 questionnaire, … |
JOHN R HURST; | 2025-08-21 |
| 164 | Non-invasive Ventilation or CPAP in OSA-COPD Following Admission for An Acute Hypercapnic Respiratory Failure PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is a major public health problem with 212.3 million prevalent cases of COPD worldwide and 3.3 million deaths related to COPD in 2019. Obstructive sleep apnoea (OSA) is the most common sleep disordered breathing. It is estimated that almost 1 billion adults have OSA worldwide. Given the increasing prevalence of obesity, co-morbid OSA is frequently seen in patients with COPD. Co-morbid OSA has been shown to increase mortality, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-07-02 |
| 165 | Chronic Obstructive Pulmonary Disease and Asthma in Workers at Navanakorn Industrial Zone, Thailand PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to determine the prevalence of asthma and chronic obstructive pulmonary disease (COPD) among workers in an industrial zone in Thailand. The main question the study aims to answer is: What is the prevalence of asthma and COPD among workers in Thailand? Participants will complete a questionnaire on respiratory symptoms and undergo pulmonary function testing. |
NARONGKORN SAIPHOKLANG; | 2026-02-03 |
| 166 | Biomarker Guided Decision-making in Acute Exacerbation of COPD: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to see if the use of two simple blood tests: C reactive protein and eosinophils, can reduce the use of steroids and antibiotics in patients with flares of chronic obstructive pulmonary disease (COPD) without reducing the chance of treatment success. Before we undertake a large trial to answer these questions, … |
VANESSA PJ LUKS; | 2025-04-16 |
| 167 | The Impact of A Weight Reduction Intervention on Clinical Outcomes in Patients With Obesity and COPD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity and COPD are increasingly common and often coexist, worsening health outcomes such as reduced lung function, exercise capacity, and increased systemic inflammation. While COPD was historically associated with underweight, obesity is now more prevalent among these patients and poses new challenges. Despite some evidence that weight loss may improve lung function, comprehensive interventions have not been fully studied. The TRIO-COPD study aims to evaluate a 20-week program combining energy restriction, adequate protein intake, … |
JENNY VAN ODIJK; | 2025-09-08 |
| 168 | The Impact of Pulmonary Rehabilitation Conducted in Therapeutic Salt Chambers on The Clinical Status of Patients With Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Title: The Impact of Pulmonary Rehabilitation Conducted in Therapeutic Salt Chambers on the Clinical Condition of Patients with Chronic Obstructive Pulmonary Disease Background and Rationale: Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder that significantly reduces patients’ quality of life and functional capacity. In the search for supportive therapeutic strategies, there is growing interest in unconventional therapeutic environments such as therapeutic salt chambers. The underground climate of the Wieliczka Salt Mine in Poland – characterized by humidity 60-75%, temperature 12.9-14.5°C, high air purity and ionization – has shown therapeutic potential. However, … |
UNIVERSITY SCHOOL OF PHYSICAL EDUCATION KRAKOW POLAND | 2025-11-26 |
| 169 | Respiratory Health and Wellbeing Post Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: We know that in low-income countries where there is a lot of tuberculosis (TB) about 20%-50% of people treated for TB have long term problems with their lungs and general wellbeing. This means they can’t always get back to doing activities they were doing before they had TB and may need further treatment, for example antibiotics, inhalers or special rehabilitation classes. Some people are unnecessarily treated again for TB because they still have a cough. There have been two international guides published recently, describing standards for providing follow up care for people treated for TB. However, … |
LIVERPOOL SCHOOL OF TROPICAL MEDICINE | 2025-09-17 |
| 170 | Pilot Study of Hyperpolarized Xenon Functional Lung Imaging in COPD Patients Undergoing Targeted Lung Denervation Related Papers Related Patents Related Grants Related Experts Highlight: Targeted Lung Denervation (TLD) Therapy is intended to improve airway smooth muscle relaxation from the site of treatment all the way to the lung periphery, which may be beneficial in the treatment of patients with COPD. To better understand the physiological effects of this therapy, the investigators intend to conduct a functional magnetic resonance imaging study of the lung with HP 129Xe study in COPD patients undergoing this procedure. HP 129Xe provides valuable regional information about ventilation and gas exchange in both healthy and diseased lung. |
XEMED | 2026-01-20 |
| 171 | Impact of Inspiratory Muscle Training (IMT) With Intermittent Variable Resistance (IVR) Versus Constant Resistance (CR) on Functional Capacity in Lung Transplantation (LTx) Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: \- Objectives: Primary Objective: To compare Maximum Inspiratory Pressure (MIP) in lung transplant (LT) patients between the use of inspiratory muscle training (IMT) with intermittent variable resistance (IVR) or constant resistance (CR) during the first six months post-transplant. Secondary Objectives: To determine whether there are differences in the outcomes of IMT with IVR and IMT with CR in the six-minute walk test, spirometry values, … |
ANDREA PÉREZ ZABALETA; | 2025-09-08 |
| 172 | The Effect of Opioid Free Anesthesia in Morbid Obese Patient Undergoing Gynecological Surgeries Using Ultrasound-Guided Bilateral Transversus Abdominus Plane Block and Dexmedetomidine Infusion: A Randomized Controlled PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aimed to determine the effects of Opioid-free anesthesia using dexmedetomidine and bilateral Transversus abdominis plane block on the quality of recovery, incidence of Opioid-free anesthesia, and post-operative pain and delirium in morbid obese patients undergoing gynecological surgeries. |
MERIHAN ALAA ELDIN AHMED; | 2025-08-11 |
| 173 | Cardio-circulatory and Respiratory Monitoring for Prediction of Outcome in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) remains a leading cause of morbidity and mortality worldwide, often necessitating invasive mechanical ventilation (MV) during acute exacerbations. Weaning these patients from MV is a critical juncture in their care, as prolonged ventilation is associated with increased complications, including ventilator-associated pneumonia, diaphragmatic dysfunction, and higher healthcare costs. Traditional weaning indices, such as the Rapid Shallow Breathing Index (RSBI), Maximum Inspiratory Pressure (MIP), and the Integrative Weaning Index (IWI), New Integrative Weaning Index (NIWI) have been employed to predict weaning outcomes. However, their predictive accuracy in COPD patients is variable, … |
KARIM OSAMA MOHAMMED SLEEM; | 2025-08-07 |
| 174 | Exacerbations and Their Outcomes in Egyptian Patients (EXACOS EG Population): Understanding The Burden of Severe Exacerbations of COPD and The Association Between Frequency of Severe Exacerbations and Clinical and Health-care Utilization Outcomes in Less Well-resourced Countries: Sample of Egyptian Patients Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is a common, progressive disease characterized by airflow obstruction which is not fully reversible. Acute exacerbations of COPD (AECOPD) are described as worsening of COPD symptoms (breathlessness, cough, and sputum volume and purulence) beyond normal day to day variation. Between 30-50% of patients with COPD experience at least one AECOPD per year (1). Even a single moderate AECOPD increases risk of future multiple AECOPD events, … |
ASTRAZENECA | 2026-03-18 |
| 175 | Breathlessness Patterns in Patients With Cancer, COPD and Heart Failure: An FMRI Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Dyspnea that persists despite optimal pathophysiological treatment is defined as persistent dyspnea. Currently all brain functional magnetic resonance imaging (fMRI) studies conducted to evaluate breathlessness have done so using healthy volunteers or have concentrated on acute breathlessness. Little is known about chronic breathlessness patterns and their modulation by different triggers. Furthermore, it is currently assumed in the palliative care literature that patients suffering from different advanced and progressive diseases such as cancer, heart failure (HF) or chronic obstructive pulmonary disease (COPD) have the same triggers, … |
LISA HENTSCH; | 2026-01-08 |
| 176 | Validation of A Chronic Obstructive Pulmonary Disease (COPD) Predictive Algorithm PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Under-diagnosis of Chronic Obstructive Pulmonary Disease (COPD) is prevalent, with an estimated 75% of adults suffering from COPD in the US, without clinical recognition. Often, the first diagnosis of COPD comes with a flare or exacerbation. In one study, 34% of patients were first diagnosed during hospitalization for an exacerbation, an event associated with a 1-year mortality rate of 26%. When COPD is finally diagnosed, it is often in the late stages, with an average lung function of 50% of normal. Conversely, COPD can be over-diagnosed, … |
BRIAN J WELLS; | 2025-11-03 |
| 177 | Optimizing Effectiveness and Implementation of COPD Self-Management Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Although COPD self-management treatment programs are effective in reducing COPD-related hospitalizations and increasing quality of life, there is a limited understanding of ‘how and why’ they work. The proposed research will use an engineering-inspired study design to identify effective COPD self-management treatment components and guide its ‘real world’ implementation. The long-term goal of this line of research is to build an optimized COPD self-management program, and scale the program up to reduce the burden of COPD at a population health level. |
AMANDA R. MATHEW; | 2025-09-22 |
| 178 | Using Multiomics to Define Mechanisms of RhinoVirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to examine exacerbations of chronic obstructive pulmonary disease (COPD) caused by a common cold virus called rhinovirus, to identify new treatments. Exacerbations are flare-ups of respiratory symptoms which are a major cause of ill health in people with COPD, and are most commonly caused by viruses. The main questions the study aims to answer are: * What processes in the body occur in response to rhinovirus infection, … |
SEBASTIAN L JOHNSTON; | 2025-08-08 |
| 179 | Prediction of Perioperative Complication Risk Using Chronic Obstructive Pulmonary Disease Assessment Test Score in Chronic Obstructive Pulmonary Disease Patients: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational cohort study is to evaluate whether the COPD Assessment Test (CAT) score can predict the risk of perioperative respiratory complications in patients aged 40 to 70 years with diagnosed Chronic Obstructive Pulmonary Disease (COPD), … |
MEHMET SERCAN ORBAK; | 2025-08-07 |
| 180 | Relative Effect of Home-based Telerehabilitation Compared to Center-based Pulmonary Rehabilitation for Patients With Chronic Obstructive Pulmonary Disease: A Multicenter Randomized Controlled Non-inferiority Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background and study aims: Chronic obstructive pulmonary disease is a leading cause of mortality worldwide. Pulmonary rehabilitation is recommended for patients to improve dyspnea, exercise capacity, and quality of life. Paradoxically, as few as 5 to 10% of eligible patients undergo pulmonary rehabilitation due to barriers such as transportation difficulties and limited availability of pulmonary rehabilitation centers. Home-based pulmonary rehabilitation using advanced telehealth technologies (telerehabilitation) may offer a solution to improve access. This study aims to compare the relative effectiveness of a home-based telerehabilitation program with center-based program. The primary objective is to assess changes in exercise endurance capacity, … |
TRISTAN BONNEVIE; | 2025-08-29 |
| 181 | An Observational Cross-sectional Study Exploring Differences in Health Between People With Non-Tuberculous Mycobacteria Pulmonary Disease and People With Bronchiectasis Without NTM Pulmonary Infection PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Nontuberculous mycobacteria (NTM) are environmental organisms found in soil and water. The majority do not cause human disease. When they do, this is mostly as a chronic lung infection in people with long-term lung problems such as chronic obstructive pulmonary disease (COPD), bronchiectasis, or cystic fibrosis. The number of people with NTM pulmonary disease (PD) is increasing, and its management can be complex, requiring prolonged treatment with multiple, often toxic, drugs in someone who may already be frail. Non-drug approaches, such as airway clearance techniques, structured exercise, … |
MARC LIPMAN; | 2025-09-25 |
| 182 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Phase II Clinical Study to Evaluate The Efficacy and Safety of HSK39004 Dry Powder Inhaler in The Treatment of Chronic Obstructive Pulmonary Disease (COPD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the safety and efficacy of the HSK39004 Dry Powder Inhaler compared with the placebo in the treatment of Chinese patients with COPD. |
HAISCO PHARMACEUTICAL GROUP | 2025-08-07 |
| 183 | A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Trial to Evaluate The Efficacy and Safety of Rademikibart As An Add-on Treatment for Acute Exacerbation in Participants With Chronic Obstructive Pulmonary Disease and Type 2 Inflammation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 2, multicenter study in adult participants with an acute COPD exacerbation and type 2 inflammation |
CONNECT BIOPHARM | 2026-03-31 |
| 184 | A Phase I Study of The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics for A Single Dose of HRS-9821 Powder for Inhalation and Inhalation Suspension Administered in Healthy Subjects and Multiple Doses in Patients With COPD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to evaluate the safety and tolerability of HRS-9821 Powder for Inhalation and inhalation suspension administered in a single dose in healthy individuals and multiple doses in patients with COPD |
ZHU LUO; | 2026-02-27 |
| 185 | A Randomized, Double-Blind, Controlled Trial of Umbilical Cord Mesenchymal Stem Cells As Adjuvant Therapy in Group E COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the efficacy and safety of allogeneic human UC-MSC to treat stage E Chronic Obstructive Pulmonary Disease (COPD). All participants in this study already receive standard treatment for COPD, which includes triple inhaled medications with LABA, LAMA and ICS. We hypothesize that UC-MSCs will improve COPD management. UC-MSCs are prepared in a certified laboratory and given intravenously. For 12 months from day 0, all patients will be observed for comprehensive safety evaluation, pulmonary function testing (PFT), quality of life indicators including questionnaires, 6-min walk test (6MWT), and inflammation biomarkers. |
TRIYA DAMAYANTI; | 2026-02-27 |
| 186 | GRACE – Graduated Response for Advanced COPD With Enhanced Support PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to explore the feasibility and potential for a positive impact of a graduated response for advanced COPD with Enhanced Support. The study is a randomized controlled trial of: * systematic needs assessment * advance care planning * crossectoral virtual conferences. Researchers will compare quality of life and healthcare use of the intervention group with a control group that will be assessed for intervention need at the last follow-up. |
KIRSTINE SKOV BENTHIEN; | 2025-12-10 |
| 187 | Evaluation of The Relationship Between Dyspnoea and Functional Airway Obstruction in Alpha-1 Antitrypsin Deficiency: A Prospective, Case-Control, Analytical Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Brief Summary: This study aims to find out if a genetic condition called Alpha-1 Antitrypsin Deficiency (AATD) is more common in people who have shortness of breath and signs of airway obstruction on their breathing tests. Alpha-1 antitrypsin (AAT) is a protein that protects the lungs from damage. AATD is an inherited condition where the body does not make enough of this protein, which can lead to lung diseases like emphysema, … |
OZLEM SENGOREN DIKIS; | 2025-09-10 |
| 188 | Investigation of The Effect of Video Game-Based Breathing Exercises on Dysfunctional Respiration in Patients With Asthma-COPD Overlap Syndrome (ACOS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma and COPD are significant respiratory diseases that can coexist, referred to as Asthma-COPD Overlap Syndrome (ACOS). Patients with ACOS experience more severe clinical outcomes, including rapid decline in lung function, increased symptom burden, and reduced quality of life. Pulmonary rehabilitation-particularly breathing exercises-is a core non-pharmacological intervention recommended for this patient group. In recent years, video game-based applications have emerged as innovative tools that enhance motivation and participation in exercise programs. However, studies investigating the effects of video game-based breathing exercises in ACOS patients are extremely limited. Additionally, although dysfunctional breathing patterns are common in this group, … |
HÜSNA GÜZEL; | 2025-09-22 |
| 189 | Feasibility of Implementing The COLA-6 Case-Finding Tool to Identify Chronic Respiratory Disease in Primary Health Care in Brazil PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators aim to evaluate whether it is feasible for healthcare professionals to implement a case-finding tool to identify individuals at high risk for chronic respiratory diseases (CRDs) during routine care for non-communicable diseases (NCDs) in primary healthcare services in Brazil. The investigators will complete a cross-sectional observational study involving 20 healthcare professionals (physicians, physiotherapists, community health agents, … |
JOHN R HURST; | 2025-07-30 |
| 190 | Research on The Construction of A Prognostic Model for COPD Complicated With Sarcopenic Obesity Based on Bioelectrical Impedance Phase Angle Technology PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to explore the diagnosis, impact, and prognostic factors of COPD complicated with sarcopenic obesity using multi-segment bioelectrical impedance phase angle technology. It seeks to clarify the diagnostic value and efficacy of body composition analysis in specific populations, analyze the relationship between phase angle and COPD severity as well as quality of life, investigate its predictive role for adverse outcomes, and reveal the effects of inflammation and metabolic disorders in sarcopenic obesity. The goal is to provide a basis for early screening and precise intervention to improve patient prognosis. |
ZHIJUN BAO; | 2026-01-26 |
| 191 | Investigation of Motor Imagery in Individuals With Chronic Obstructive Pulmonary Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study was to compare the motor imagery ability of individuals with Chronic Obstructive Pulmonary Disease (COPD) with those without COPD. |
LÜTFIYE AKKURT; | 2025-09-15 |
| 192 | Association Between Immune Status and Disease Control in Patients With Inflammatory Airway Diseases PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to learn how the body’s immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked to how severe the disease is or how well it is controlled. Participants will: 1. Answer questions about their health and symptoms. 2. Give blood samples 3. Have lung function tests and other standard check-ups. 4. share sleep study results. We will compare people with airway diseases to healthy volunteers to see how their immune systems differ. |
FIRST AFFILIATED HOSPITAL OF NINGBO UNIVERSITY | 2026-03-25 |
| 193 | Effectiveness and Safety of Laser Acupuncture on Pulmonary Function Test and Quality of Life in Patients With Chronic Obstructive Pulmonary Disease) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to evaluate the effectiveness and safety of laser acupuncture as an adjunct therapy in patients with chronic obstructive pulmonary disease (COPD). The main research questions are: * Does laser acupuncture, when combined with standard pharmacological treatment, improve lung function (measured by FEV1% and FEV1/FVC ratio) more than sham laser acupuncture after 4 weeks of therapy? * Does this combination also lead to better quality of life, as assessed by the COPD Assessment Test (CAT) and the St. George’s Respiratory Questionnaire (SGRQ), compared to the control group, … |
DWI LESTARI AYUNINGTYAS; | 2025-12-31 |
| 194 | Evaluation of The Effects on Carbon Dioxide (paCO2) of A New Oronasal Mask in Patients With Severe Exacerbation of COPD Requiring Non-Invasive Mechanical Ventilation: A Single-Center, Exploratory, Randomized Cross-Over Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This single-center, crossover study aims to investigate the effects of the new OptiNIV oronasal mask used during NIV in COPD patients with respiratory acidosis following an exacerbation. The goal is to evaluate whether the clinical benefits, in terms of reducing PaCO2 levels, are greater with the new mask compared to a traditional one (Visairo Mask). |
STEFANO NAVA; | 2025-07-23 |
| 195 | Prospective, Randomized, Controlled, Open-Label Single-Center Trial Comparing High-Velocity Nasal Insufflation (HVNI) Versus Non-Invasive Ventilation (NIV) for Acute Respiratory Failure in Guillain-Barré Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will involve 70 adult patients with Guillain-Barré syndrome who have severe breathing problems. It will compare two types of breathing support: high-velocity nasal cannula (HVNC) (which delivers heated and humidified air at 35-60 L/min) and bi-level noninvasive ventilation (NIV) (which uses two pressure levels: inspiratory positive airway pressure (IPAP) 10-16 cmH₂O and expiratory positive airway pressure (EPAP) 5-8O). The main goal is to see how many patients can stop using non-invasive support without needing a breathing machine by Day 30. Other goals include how long it takes to stop using support, how comfortable patients feel, … |
AHMAD SHADDAD; | 2025-05-30 |
| 196 | Evaluation of The Impact of Pleuropulmonary Ultrasound Performed By The Emergency Physician on The Diagnosis of Dyspnea in The Prehospital Setting PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Dyspnea is a subjective symptom perceived by the patient as a sensation of breathing discomfort, suffocation, lack of air or difficulty inhaling or exhaling. It is a frequent reason for calling for help (8% of calls). The most seriously ill patients require the dispatch of specialized teams capable of initiating respiratory support in order to reduce the morbidity and mortality of these patients. In France, these teams are medicalized by an emergency physician within the Mobile Emergency Resuscitation Services (SMUR). This is only rarely the case outside France, … |
PAULINE MARCHETTO; | 2025-09-26 |
| 197 | A Phase IIb, Randomized, Double-blind, Placebo- Controlled, Parallel Group Study to Assess The Efficacy and Safety of Ensifentrine-glycopyrrolate Fixed-dose Combination at Two Dose Levels Compared to Glycopyrrolate or Ensifentrine Monotherapy in Subjects With COPD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will assess the safety and efficacy of fixed dose combinations of ensifentrine with two different glycopyrrolate dose levels compared to placebo and to the individual components of the fixed dose combinations, each administered twice a day via standard jet nebulizer, in adult subjects with chronic obstructive pulmonary disease (COPD). |
VERONA PHARMA PLC | 2026-03-30 |
| 198 | Comparative Effects of Manual Positive End Expiratory Pressure and Non Invasive Continuous Air Pressure in COPD Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized clinical trial aims to compare the effectiveness of Manual Positive End Expiratory Pressure (PEEP) and Non-Invasive Continuous Positive Airway Pressure (CPAP) in patients with Chronic Obstructive Pulmonary Disease (COPD). A total of 42 patients will be randomly assigned to two groups: one receiving manual PEEP therapy and the other receiving CPAP therapy, over a 4-week period. The primary goal is to assess and compare improvements in respiratory rate, oxygen saturation (SpO₂), and patient-reported breathlessness and comfort using standardized tools such as pulse oximetry, digital spirometry, the Borg dyspnea scale, … |
ARJUMAND BANO; | 2025-07-23 |
| 199 | Effect of Rehabilitation on The Respiratory Signal in Patients With Chronic Obstrucitve Pulmonary Disease (COPD) and Exercise-Induced Desaturation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim is to study the effect of SSOT during a 3-week in-patient pulmonary rehabilitation programme. Further aim is to analyse exercise endurance, distinguishing between those exercising whilst breathing air at 760m normoxia, breathing air at 1600m hypoxia, or breathing SSOT at 760m hyperoxia conditions, during in-patient pulmonary rehabilitation. The objective of the main study is to provide long-awaited data concerning the use of SSOT during training. At present it is unclear whether patients with chronic lung diseases who reveal an SpO2 \> 88% at rest, but desaturate during exercise, and, thus, … |
EASTERN SWITZERLAND UNIVERSITY OF APPLIED SCIENCES | 2025-08-06 |
| 200 | A Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled (Open-Label), Phase IIa Clinical Study to Evaluate The Safety and Efficacy of JKN2304 Inhalation Solution in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this Phase IIa study is to evaluate the safety, efficacy, and pharmacokinetics of JKN2304 Inhalation Solution in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD). The study is a multicenter, randomized, double-blind, placebo-controlled, and active-controlled (open-label) trial. Participants are randomized to receive JKN2304 (2 mg once daily or 2 mg twice daily), Placebo, or Formoterol Fumarate Inhalation Solution for a treatment period of 14 days. |
JOINCARE PHARMACEUTICAL GROUP INDUSTRY | 2026-03-04 |