Clinical Digest: Recent Clinical Trials on Diabetes (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Diabetes. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Diabetes (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes Mellitus: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the effectiveness of periodontal treatment associated with the use of a tongue scraper, compared with the same treatment combined with antimicrobial photodynamic therapy (aPDT), … |
CARLA ANDREOTTI DAMANTE; | 2026-03-16 |
| 2 | Group-Care for Hypertension and Diabetes Management in Nepal: A Cluster Randomized Implementation Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Hypertension and diabetes represent significant and growing public health challenges in Nepal, particularly in underserved communities. Traditional individual-based care approaches may not adequately address the multifaceted needs of patients with these chronic conditions in resource-limited settings. The group care model, which combines peer support, education, and clinical care, … |
NEHA LIMAYE; | 2026-02-27 |
| 3 | Peer Support and Remote Patient Monitoring for Black Adults With Type 2 Diabetes: PROMOTE Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will include a type 1 hybrid effectiveness implementation study to evaluate the effectiveness of the PROMOTE (peer support plus remote patient monitoring) program among Black adults with uncontrolled type 2 diabetes recruited from local primary care practices in Jefferson County, Alabama. Additionally, a mixed methods evaluation to characterize the contextual factors relevant to implementation of PROMOTE using Practical Robust Implementation Science Model (PRISM) will be conducted. |
CAROLINE PRESLEY; | 2026-03-17 |
| 4 | The Impact of Early Automated Insulin Delivery (AID) Therapy on Diabetes Control and Comorbidities, and Cost-effectiveness of AID Treatment – A Prospective, Randomized, Controlled Study on Pediatric Patients With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate the effect of early initiated automated insulin de-livery (AID) treatment in type diabetes in children aged 7-16 years to glycemic control, diabe-tes distress of patients and caregivers, long-term micro- and macrovascular complications and cost-effectiveness compared to multiple daily injections (MDI) and continuous glucose monitoring (CGM). The immediate costs of AID therapy are higher than costs of multiple daily injection therapy, and there has been debate whether the more expensive AID therapy is justified. No research on the cost-effectiveness of AID use in children has been conducted so far in Finland, … |
TERO VARIMO; | 2026-03-17 |
| 5 | A Multicenter, Randomized, Double-blind, Double-dummy, Parallel-group, Active-controlled Clinical Trial to Evaluate Efficacy and Safety of QLG1091 Versus Rybelsus As Add-on to Metformin in Subjects With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is to evaluate the efficacy and safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes. The primary objective is to demonstrate equivalence of QLG1091 and Rybelsus. This study is a randomized, double-blind, double-dummy, active-controlled, parallel-group, multi-center Study. The total duration of the study will be approximately 33 weeks including screening and follow-up. |
QILU PHARMACEUTICAL | 2026-03-23 |
| 6 | A Dose-Escalation Study Evaluating The Safety and Pharmacokinetics of IMC-S118AI in HLA-A*02:01-Positive Participants With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a first-in-human (FIH) study designed to assess the safety, tolerability, and pharmacokinetic (PK) profile of IMC-S118AI in single-ascending dose (SAD) and multiple-ascending dose (MAD) regimens. This study will potentially also explore the effects of multiple-dosing regimens on preservation of beta-cell function in Stage 3 Type 1 diabetes. |
IMMUNOCORE | 2026-03-25 |
| 7 | A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to determine the efficacy of oral KAI-7535 once daily compared with placebo on percent change in body weight in participants living with obesity or overweight, with at least 1 weight-related comorbidity, without diabetes mellitus. Efficacy in participants with type 2 diabetes mellitus will be evaluated. Safety and tolerability and other weight-related outcomes will be evaluated in both types of participants. |
KAILERA | 2026-03-27 |
| 8 | Effects of Exercise And/or Β-hydroxy-β-methylbutyrate Supplementation on Muscle Mass, Physical Performance and Insulin Resistance in Older Diabetes With Low Muscle Mass: A Randomized, Double-blind, Placebo-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators aimed to examine if β-hydroxy-β-methylbutyrate (HMB) supplementation enhances the effects of exercise on muscle mass, physical performance and insulin resistance and observe potential residual effects in older diabetes with low muscle mass, and to find the optimal treatment plan. |
WU SHANGLING; | 2026-03-31 |
| 9 | Real-time Engagement for Learning to Effectively Control Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a clinical trial that includes a run-in period, a 90 day micro-randomized trial, and a 90-day observational period. The goal of this study is to evaluate whether providing paired real time glycemic and health behavior data in a smartphone app leads to better glycemic control among adolescents and young adults with T2D. Glycemic control will be monitored using Continuous Glucose Monitors (CGM), and health behavior data will be collected via a Fitbit activity tracker and a research app (Healthmine). Participants will be prompted to view and reflect on glycemic trends and health behavior data (Fitbit data, … |
MARY ELLEN VAJRAVELU; | 2025-10-01 |
| 10 | Duodenal Recellularization Via Electroporation Therapy for Suboptimally Controlled Type II Diabetes Mellitus and Steatotic Liver Disease (DRESS-1 Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed to evaluate the efficacy, safety, and mechanisms of ReCET procedure in patients with T2DM and its effect on MASLD. |
STEPHEN KK NG; | 2026-02-05 |
| 11 | Remotely Delivered Mindfulness-Based Diabetes Education for Rural Adults With Uncontrolled Diabetes and Elevated Distress PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes distress is common affecting over one-third of people with type 2 diabetes, negatively impacting self-management and outcomes, and disproportionately affecting low-income individuals. The proposed project will conduct a pilot randomized controlled trial comparing remotely delivered Mindfulness-Based Diabetes Education plus remote patient monitoring of blood glucose to standard Diabetes Self-Management Education in rural Black adults with type 2 diabetes and elevated diabetes distress who receive care within federally qualified health centers to assess feasibility and acceptability. |
CAROLINE PRESLEY; | 2026-03-18 |
| 12 | Effects of Whole Fruit on Glycemic Control, Liver Fat, and Cardiovascular Disease Risk Factors in Adults With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will determine the effects of consuming whole fruit on blood sugar control, liver fat, and cardiovascular health in adults with type 2 diabetes who are not treated with insulin. |
COURTNEY PETERSON; | 2026-02-03 |
| 13 | Plantar Pressure and Acceptance of The LEEF-shoe in Individuals With Diabetes-related Neuropathy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Rationale: Of all individuals with diabetes, 19-34% develop a foot ulcer in their lifetime, and nearly 25% of these ulcers result in amputation. Ulcer prevention is often addressed by prescribing orthopedic shoes (OS). However, the effectiveness of OS is highly dependent on the individual shoe technician’s skill and experience, and OS is frequently perceived as unattractive by users. To overcome these limitations, the LEEF-shoe was developed. It eliminates the need for a fully individualized shoe technician approach by using a standardized protocol to determine the rocker settings. This may provide comparable plantar pressure relief, … |
UNIVERSITY MEDICAL CENTER GRONINGEN | 2026-03-23 |
| 14 | Continuous Glucose Monitoring to Detect Postpartum Dysglycemia in Patients With Gestational Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to determine the ability of postpartum continuous glucose monitoring (CGM) for subjects with gestational diabetes (GDM) to predict dysglycemia on 4-12 week postpartum oral glucose tolerance test (OGTT). |
LAURA DICKENS; | 2026-02-13 |
| 15 | GLP-1 Receptor Agonist-Induced Loss and Impairment of Muscle Mass – Evaluation of Response PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide. By doing so, we hope to gain a clearer understanding of how semaglutide affects muscle health and function. Our goal is to ensure the medication supports long-term well-being, particularly for people who may be at higher risk of muscle loss. This study involves (3) in-person study visits. At each visit, … |
UNIVERSITY OF ALBERTA | 2026-03-13 |
| 16 | Culturally Tailored Program for Food-Insecure Adults With Type 2 Diabetes: The SPICE-D Study (Support for People Through Inclusive Cultural Eating for Diabetes) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pilot intervention study is to learn if culturally appropriate food bundles and nutrition education can help people with diabetes who struggle to afford healthy food in patients with diabetes receiving care at Community Care Clinic in Winston-Salem, … |
MEGAN B IRBY; | 2026-03-25 |
| 17 | A Randomized, Open-Label, Treat-to-Target, Parallel-Controlled Phase II Clinical Study to Evaluate The Safety and Efficacy of Fixed-Dose Titration and Individualized-Dose Titration of SHR-3167 in Adults With Type 2 Diabetes Inadequately Controlled With Oral Antihyperglycemic Agents PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety and glycemic control of SHR-3167 fixed-dose titration and individualized-dose titration in adults with Type 2 Diabetes inadequately controlled with oral antihyperglycemic agents. |
ZHEN LIANG; | 2026-03-16 |
| 18 | Artificial Intelligence-based Methods to Predict Disease Progression in Youth With Type 2 Diabetes: A Digital Twin Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Currently, clinicians are unable to predict a patient’s risk of long-term disease progression and development of a long-term complication based on the data that is available to them. The first aim of this is to develop and validate an Artificial Intelligence (AI) powered prediction model for Type 2 Diabetes (T2D) disease progression using existing data from previously collected studies and real-world electronic health medical data. Investigators will use clinical, pharmacologic, … |
SHYLAJA A SRINIVASAN; | 2025-12-04 |
| 19 | Continuous Glucose Monitoring for Post-discharge Diabetes Management PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an investigator initiated prospective, randomized controlled trial which aims to compare two groups of patients with either type 2 or steroid-induced diabetes who are discharged with insulin. The intervention group will use the Libre 3 Plus continuous glucose monitoring (CGM) system at discharge, … |
GRENYE O’MALLEY; | 2026-04-03 |
| 20 | A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate The Efficacy and Safety of Once-Weekly RO7795068 Administered to Participants With Obesity or Overweight and Type 2 Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the efficacy and safety of RO7795068, a dual glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with placebo for weight management in participants with obesity or overweight and Type 2 diabetes mellitus (T2DM). |
HOFFMANN LA ROCHE | 2026-03-17 |
| 21 | Development and Validation of Psycho-Social Program (PSP) for Mental Health Problems Among Patients With Type 2 Diabetes Mellitus (T2DM): A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to determine the effectiveness of a structured psycho-social program (PSP) in improving mental health outcomes among patients with Type 2 diabetes mellitus (T2DM). The intervention is designed to reduce symptoms of depression, anxiety, and diabetes-related distress (DD) by addressing maladaptive thoughts, emotional responses, and coping behaviors associated with chronic illness management. Through structured sessions incorporating cognitive restructuring, stress management techniques, behavioral activation, and adaptive coping strategies, participants will learn to manage emotional distress more effectively while improving treatment adherence and daily functioning. The intervention is expected to enhance psychological well-being, promote healthier coping mechanisms, … |
QASIR ABBAS; | 2026-03-06 |
| 22 | Continuous Glucose Monitoring As A Tool to Promote Physical Activity in Prediabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research explores how wearable glucose monitors might help prevent type 2 diabetes in people at risk of developing the disease. Type 2 diabetes affects more than 1 in 10 Americans and costs the nation $327 billion annually. Even though it’s clear that physical activity helps prevent diabetes, and that even small increases in daily movement (like walking or climbing stairs) can significantly lower risk, … |
JINGHUI YANG; | 2026-03-06 |
| 23 | SBI 2024-2026 STENO FOOD CONCEPT PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates whether a digital patient education program can improve adherence to KDIGO 2022 dietary recommendations (low sodium and optimal protein intake) among patients with type 2 diabetes and chronic kidney disease (eGFR 30-59 ml/min). |
THOMAS P ALMDAL; | 2026-03-20 |
| 24 | A Multicenter Phase 2 Clinical Study to Evaluate The Efficacy and Safety of GZR101-80 Injection in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Oral Antidiabetic Drugs or Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Basal/Premixed Insulin PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will be conducted to evaluate the efficacy and safety of GZR101-80 Injection in patients with type 2 diabetes mellitus inadequately controlled on oral antidiabetic drugs or Basal/Premixed Insulin. |
GAN & LEE PHARMACEUTICALS | 2026-02-04 |
| 25 | Effect of Resistance Training on Depression and Quality of Life in Type 1 Diabetic Women PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Find out the effects of resistance training on depression, sleep quality, and quality of life in women with type 1 diabetes mellitus |
SAHER LOTFY EL GAYAR; | 2026-03-12 |
| 26 | A Single-Arm, Open-Label Clinical Study of IPSC-Derived Islet Cells for The Treatment of Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single-arm, open-label clinical trial designed to assess the safety and therapeutic efficacy of iPSC-derived islet cell infusion in patients with diabetes mellitus. |
ZHANG JUNQING; | 2026-03-11 |
| 27 | Clonal Fetal Mesenchymal Stem Cell (cfMSC) Therapy for Type II Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the feasibility, safety and clinical efficacy of the novel clonal fetal mesenchymal stem cell (cfMSC) therapy in patients with type II diabetes mellitus. |
SHENZHEN GENO IMMUNE MEDICAL INSTITUTE | 2026-03-27 |
| 28 | Low-Dose Glucagon and Automated Insulin Delivery for Prevention of Spontaneous Exercise-Induced Hypoglycemia in People With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of the study is to evaluate whether pre-exercise administration of low-dose subcutaneous glucagon prevents or attenuates exercise-induced declines in plasma glucose concentration during and after moderate-intensity continuous exercise (MICE) performed approximately 90 minutes after a meal in adults with type 1 diabetes using an automated insulin delivery (AID) system. The primary endpoint is the difference in the change in plasma glucose (PG) from exercise initiation to the nadir during exercise and through the 2-hour post-exercise period between the glucagon (GCN) and carbohydrate (CHO) visits. |
STENO DIABETES CENTER COPENHAGEN | 2026-02-27 |
| 29 | Making Diabetes Care Fit for Young Adults Living With Type 1 Diabetes: Observations, Reflections and Expert Opinions PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical study is to assess differences in collaborative efforts to make care fit between clinical encounters in usual care and those using the Making Care Fit tool among young adults with type 1 diabetes and their clinicians. The main question it aims to answer is: What are the differences in collaborative efforts to make care fit between clinical encounters in usual care and those using the Making Care Fit tool? Researchers will compare clinical encounters in usual care with encounters supported by the Making Care Fit tool to examine differences in collaborative efforts to align care and daily life. Participants will: * Take part in an observed clinical encounter with their clinician * Participate in a post-encounter video-stimulated interview reflecting on the consultation * Complete questionnaires about their experiences of the consultation |
MARLEEN KUNNEMAN; | 2026-03-27 |
| 30 | Impact of Concurrent Diabetes on Quality-of-life Changes During Immunotherapy – A Prospective Longitudinal Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to see how type 2 diabetes affects quality of life in cancer patients receiving immunotherapy. We want to know if patients with diabetes have a greater decline in quality of life over six months compared to those without. The main question we aim to answer is: \- How does quality of life change over six months in patients with versus without diabetes? Participants will complete quality-of-life surveys at the start, then at 3 and 6 months. This will help us see if diabetes adds extra challenges during cancer treatment |
DEBBIE MARIA MADSEN; | 2026-03-12 |
| 31 | A Registry-based Randomized Controlled Trial of Moderate-intensity Statin Therapy Vs. Individualized Low-density Lipoprotein Cholesterol Target-based Therapy for Primary Prevention of Cardiovascular Events in Patients 70 Years of Age or Older With Type 2 Diabetes (iTARGET-Elderly Study) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Statins are the cornerstone of cardiovascular disease (CVD) prevention through the lowering of low-density lipoprotein cholesterol (LDL-C). While the benefits of intensive LDL-C lowering are well-established for secondary prevention, evidence remains insufficient for primary prevention in the elderly-specifically for individuals aged 70 years or older with type 2 diabetes who have no prior history of atherosclerotic cardiovascular events. Current guidelines generally recommend moderate-intensity statins for this population based on extrapolated data. However, there is a significant evidence gap regarding whether these older adults, who have not yet experienced a cardiovascular event, … |
SIN GON KIM; | 2026-03-10 |
| 32 | The Effect Of Color Rotation Technique Training On İnsülin Self-management İn Diabetic Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes mellitus (DM) is a chronic disease characterized by impaired carbohydrate, protein, and lipid metabolism, resulting from a deficiency of insulin hormone secreted by the pancreas and/or the body’s inability to utilize it even when sufficient insulin is secreted. As a frequently observed chronic disease, diabetes is a significant public health problem; if left uncontrolled, it can lead to serious complications and negatively impact quality of life.Individual management of treatment is crucial for successful treatment and glycemic control in diabetes. Due to the complexity of diabetes management related to insulin use, … |
MERVE AYŞE ŞAHIN; | 2026-04-03 |
| 33 | Polyphenol Metabotypes in People With Diabetes Type 2 PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This cross-sectional study seeks to characterize the overall polyphenol metabotype in patients with T2DM in comparison to age-matched individuals without diabetes. Additionally, the study aims to identify factors that influence the polyphenol metabotype (transit time and gut microbial capacity to degrade polyphenols in particular). |
BRUNO LAPAUW; | 2026-03-23 |
| 34 | ARISE: Achieving Routine Intervention and Screening for Emotional Health: Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this project is to evaluate the effectiveness of diabetes distress screening and intervention on patients with type 2 diabetes mellitus (T2DM). |
ARSHIYA BAIG; | 2026-03-06 |
| 35 | Prevalence of Diabetes-related Distress Among Patients Living With Type 2 Diabetes in A University Hospital Center and Identification of Its Associated Factors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes-related distress is a psychological construct associated with poorer glycaemic control in people living with diabetes. In France, few data are available on this topic and none focus specifically on adults with type 2 diabetes. Diabetes-related distress is not mentioned in the current French national guidelines on the management of type 2 diabetes, whereas international societies such as the ADA and, more recently, … |
PHILIPPE CAROLI-BOSC; | 2026-03-31 |
| 36 | Adapting Single Sessions Interventions for Type 1 Diabetes (ASSISTED): Integrated Pediatric Care to Reduce Depression and HbA1c PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if implementing a single-session depression intervention for youth with type 1 diabetes (T1D) is feasible and acceptable to patients. can help improve mood and health outcomes. It will also learn about the initial efficacy of the intervention. The main questions it aims to answer are: 1. Is a single-session depression intervention for youth with T1D feasible to recruit and implement? 2. Is a single-session depression intervention for youth with T1D acceptable to patients (i.e., … |
ALEXANDRA MONZON; | 2026-01-14 |
| 37 | Effectiveness and Implementation of An AI-Driven Blended Care Model for Type 2 Diabetes Management in Primary Care: A Single-Blind, Cluster Randomized Controlled Trial in Zhangjiagang, China PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this cluster randomized clinical trial is to learn if an AI-enabled blended care model (the BRIDGE program) works to treat type 2 diabetes in adults. It will also learn about the cost-effectiveness and implementation feasibility of this model in primary care settings. The main questions it aims to answer are: Does the AI-driven intervention lower HbA1c levels (blood sugar) compared to standard care? Does this model improve participants’ quality of life, self-management behaviors, … |
PEKING UNIVERSITY | 2026-02-23 |
| 38 | A Multi-center, Randomized, Open-label, Active Comparator-controlled, Phase 4 Clinical Trial to Evaluate The Efficacy and Safety of Empagliflozin or Glimepiride Combination Therapy in Type 2 Diabetes Mellitus Patients Inadequately Controlled With Metformin and Sitagliptin PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the efficacy and safety of Empagliflozin or Glimepiride Combination Therapy in Type 2 Diabetes Mellitus Patients |
IN-KYUNG JEONG; | 2026-01-26 |
| 39 | Strategies for Improving The Detection of Dysglycemia in The Postpartum Period in Women With Gestational Diabetes: Electronic Reminders and New Diagnostic Criteria PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Gestational diabetes mellitus (GDM) is one of the most common clinical conditions in pregnancy, with an increasing incidence due to the rise in overweight women and the postponement of motherhood. It is associated with perinatal complications and an increased risk of developing prediabetes and type 2 diabetes after delivery. Therefore, it is recommended that a 75g oral glucose tolerance test (OGTT-75g) be performed between 6 and 12 weeks postpartum. Despite its relevance, … |
TATIANA ASSUNÇÃO ZACCARA; | 2026-03-24 |
| 40 | Digital Care Community Common Good Program Enhances Holistic Health Management for Middle Aged and Older Adults With Diabetes Mellitus and Multiple Chronic Conditions PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study was to explore the effectiveness of the Digital Care Community Common Good program in improving disease control indicators, self-management abilities, depression, and quality of life among patients with comorbidities and type 2 diabetes. The study was designed as a two-year experimental study, with a specific area in New Taipei City selected as the research site. In the first year, the main tasks include establishing an integrated intervention team composed of primary healthcare providers and community resources, expanding the functionalities of the mHealth platform, developing digital educational materials for diabetes comorbidities care, … |
CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY | 2026-02-27 |
| 41 | A Phase 4, Open-Label, Single-Arm, 46-Week Study to Investigate The Safety and Efficacy With Tirzepatide in Adult Indian Participants With Either Type 2 Diabetes or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of this study is to measure the safety and efficacy of tirzepatide in adult participants in India who have type 2 diabetes or who have obesity or overweight without type 2 diabetes. Participation in the study will last about 46 weeks. |
KARTIKEYA PARMAR; | 2026-02-27 |
| 42 | Production Of Induced Pluripotent Stem Cells (iPSCs) For The Generation Of Insulin-Producing Β Cells PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this interventional study is to generate induced pluripotent stem cells (iPSCs) from somatic cells and differentiate them into insulin-producing β cells in patients with metabolic and genetic pancreatic diseases and in healthy controls. The main questions it aims to answer are: Can somatic cells from healthy individuals and patients with diabetes be successfully reprogrammed into iPSCs? Can these iPSCs be differentiated into functional insulin-producing β cells suitable for studying disease mechanisms and developing cell-based therapies? Participants will provide a single biological sample (either a 3 mm skin punch biopsy, a blood sample, … |
LORENZO PIEMONTI; | 2026-03-18 |
| 43 | National Forsøgsordning Med Glukosesensorer Til Type 2-diabetes: Glukosesensorer Til Gravide Med Type 2-diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the use of glucose sensors in pregnant women with type 2 diabetes to improve insulin regulation, pregnancy and birth outcomes, … |
ODENSE UNIVERSITY HOSPITAL | 2025-07-31 |
| 44 | A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity Who Do Not Have Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to determine the effects of KAI-9531 administered by subcutaneous (SC) injection once weekly compared to placebo on percent change in body weight. |
KAILERA | 2026-03-09 |
| 45 | Duodenal Recellularization Via Electroporation Therapy As An Early Treatment for Type 2 Diabetes Mellitus (DREAM-1 Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed to evaluate the efficacy and safety of endoscopic duodenal re-cellularization therapy in individuals with in patients with a recent diagnosis of type 2 diabetes mellitus (T2DM). |
STEPHEN KK NG; | 2026-01-29 |
| 46 | Metabolic Effects of Hybrid Closed-loop Insulin Delivery in People With Diabetes After Pancreatectomy: A Randomized Cross-over Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Individuals with diabetes secondary to pancreatectomy experience impaired quality of life, partly due to the challenges of managing highly variable blood glucose levels. Hybrid closed-loop (HCL) automated insulin delivery (AID) systems, widely evaluated in type 1 diabetes, may improve both metabolic outcomes and quality of life in this population. A review of the literature identified a few observational studies reporting promising results with HCL systems in the context of post-pancreatectomy diabetes. Only one randomized trial has evaluated AID in this population, showing excellent outcomes, but using a complex bihormonal system that is not yet commercially available worldwide. Consequently, … |
CORALIE AMADOU; | 2026-02-24 |
| 47 | Advanced Hybrid Closed-Loop Treatment in Adults With Type 1 Diabetes Not Meeting Glycaemic Targets – The Steno780G Follow-up Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Automated insulin delivery systems, also known as closed-loop systems, have shown to improve TIR, TAR, and TBR compared with insulin pump and CGM systems that cannot automatically dose insulin. Only few studies have described long-term use of AID systems over several years. Real-world studies suggest that the beneficial effects of AID systems on glycemic outcomes are sustained over time; however, a modest increase in body weight has been observed in some users, … |
MERETE CHRISTENSEN; | 2026-03-16 |
| 48 | Phase 2 Randomized, Double-blind, Placebo-Controlled Trial Assessing The Efficacy and Safety of Icovamenib in Participants With Type 2 Diabetes Not Achieving Glycemic Targets Despite GLP-1-Based Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase 2 randomized, double-blind, placebo-controlled trial assessing the efficacy and safety of icovamenib in participants with Type 2 Diabetes (T2D) not achieving glycemic targets despite Ozempic-based therapy. |
BIOMEA FUSION | 2026-03-31 |
| 49 | Early AID Pilot for Newly Diagnosed T1D PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Type 1 diabetes is a common chronic medical condition among youth in the US that requires intensive glycemic management to prevent long-term morbidity and mortality. Current pediatric diabetes care in the US underutilizes automated insulin delivery (AID) systems, which are the best available tools for promoting tight glycemic control while reducing user burden. This proposal aims to support early and sustained use of AID systems by examining and optimizing conditions, evaluating glycemic outcomes, and identifying contextual facilitators and barriers of implementation. |
DAVID MAAHS; | 2026-03-30 |
| 50 | Brewer’s Spent Grain A Potential Ally for The Prevention of Type II Diabetes: Determination of Blood Glucose Absorption of New Foods PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this project is to determine the impact of incorporating brewers’ spent grain into cookie formulations on postprandial blood glucose absorption levels following consumption. The methodology for assessing blood glucose response to cookies formulated with brewers’ spent grain is described as follows. A total of 20 participants will be recruited from the Universidad Católica del Uruguay. Volunteers will be recruited through institutional email dissemination, … |
MARIA BELEN GUTIERREZ; | 2026-03-03 |
| 51 | Continuous Glucose Monitoring in An Underserved Population: Impact on Glucose Control, Patient Reported Outcomes, Healthcare Utilization, and Long Term Complications PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators aim is to conduct a randomized clinical trial in an underserved population who are either uninsured or on Medicaid and taking at least one injection of insulin daily. The investigators believe that this study will lead to considerable alleviation of health disparities and provide better care for an underserved population. This will be a pilot study to evaluate the feasibility of such a trial in this population before doing a larger multicenter trial. |
SHAVETA GUPTA; | 2026-03-02 |
| 52 | A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial Assessing The Efficacy and Safety of Icovamenib in Participants With Type 2 Diabetes Who Are Not Achieving Glycemic Targets Despite Antihyperglycemic Medications PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 2, randomized, double-blind, placebo-controlled trial assessing the efficacy and safety of icovamenib in participants with Type 2 Diabetes who are not achieving glycemic targets despite antihyperglycemic medications. |
BIOMEA FUSION | 2026-03-31 |
| 53 | Effects of Ramadan Fasting on Type 1 Diabetic Children in Assiut Governorate, Egypt PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: assess the effects of Ramadan fasting on Type 1 diabetic children, fasting on their own, and to assess the validity of IDF-DAR risk calculator as a predictor of complications. |
AHMED MAHMOUD ISMAIL RASHED; | 2025-07-31 |
| 54 | Development of Telenursing for Diabetes Self-Management Education and Support (DSMES) Among Patients With Type 2 Diabetes Mellitus in Thailand: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial aims to develop and evaluate a telenursing-based Diabetes Self-Management Education and Support (DSMES) program with uncontrolled type 2 diabetes mellitus in Thailand. The program is designed to improve diabetes self-management through nurse-led education, behavioral support, … |
RAMIDA SUBPAIBOONKIT; | 2026-03-24 |
| 55 | Effects of Continuous Glucose Monitoring on Patients With Type 2 Diabetes Treated With Insulin During Post-Discharge Transition: A Multicenter Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The transition from inpatient care to the home setting is a critical phase for glycemic management, often associated with decreased adherence and deterioration of glycemic control. This multicenter, randomized, open-label, … |
JIAN ZHOU; | 2026-02-20 |
| 56 | EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY-BIASED ULTRA LONG-ACTING GLP-1RA, IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES: A PHASE 3, MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED TRIAL (VESPER-5) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this clinical study is to learn about the safety and effects of the study medicine to help adults with obesity or overweight and type 2 diabetes lose weight. Being overweight or obese means carrying too much body weight. Type 2 diabetes is a condition where there is too much sugar in the blood. The study medicine is given by a shot under the skin in the belly area. The participants will be trained to do this at home once every week. About 660 out of 1000 adults will also receive the study medicine and about 330 out of 1000 adults will receive placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. The investigators will compare the experiences of people receiving the study medicine to those of the people who do not. This will help us assess if the study medicine is safe and effective. People will take part in this study for about 21 months. During this time, they will have about 14 study visits at the site and 5 over the phone. |
PFIZER | 2026-03-30 |
| 57 | Sleep Screening and Intervention for Adolescents With Type 1 Diabetes in A Clinical Diabetes Center PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is evaluating an in-clinic sleep screening and intervention algorithm for youth with type 1 diabetes. This study will assess health care provider feasibility of completion of intervention and long term follow up for adolescents with T1D. |
ERIN COBRY; | 2026-03-27 |
| 58 | The Effects of The Telemedicine-Based Behavioral Intervention on Improving The Outcomes of Diabetic Patients in Northwest Amhara Tertiary Hospitals, Ethiopia, 2025/26: A Quasi-Experimental Study Intervention Protocol PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this quasi-experimental clinical study is to learn whether a telemedicine-based behavioral intervention can improve health outcomes among adult patients with diabetes receiving care at tertiary hospitals in Northwest Amhara, … |
EYOB KETEMA BOGALE; | 2026-02-20 |
| 59 | Feasibility Study of Extended Wear Insulin Infusion Set Options During Home Use in People With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This feasibility study is a prospective, single center, multi-arm study evaluating possible enhancements to the SteadiSet extended wear infusion set. |
TANDEM DIABETES CARE | 2026-03-05 |
| 60 | Gut Microbiota, Diet-INDuced Obesity and Type 2 Diabetes in New Caledonia – MIND PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In recent years, the global rise in obesity and type 2 diabetes has become a major public health issue. In New Caledonia, 38% of the adult population has a body mass index ≥30. At the same time, the prevalence of type 2 diabetes continues to rise steadily. The burden of these diseases does not affect communities uniformly. While known factors such as diet, physical activity, and socioeconomic conditions play a role, studies have demonstrated the involvement of the gut microbiota in the development of metabolic disorders, particularly obesity and insulin resistance. However, … |
INSTITUT PASTEUR | 2026-03-09 |
| 61 | Effect of A Structured Narrative Education Program on Glycemic Control in Adults With Type 2 Diabetes in Primary Care: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Type 2 diabetes is common in primary care, and daily self-care behaviors are essential for achieving blood sugar targets. This randomized, two-arm clinical trial will evaluate whether a structured narrative education program added to usual diabetes care improves glycemic control compared with usual care alone in adults with type 2 diabetes. Eligible participants (age ≥18 years) with suboptimal glycemic control (HbA1c ≥7.0% in the last 3 months) will be randomized 1:1 to either standard care or standard care plus narrative education. The narrative education program will be delivered by a family physician over 3 months and includes two individual face-to-face sessions (approximately 20-30 minutes) at Day 0 and Day 15 and four brief telephone reinforcement calls (approximately 3-5 minutes) on Days 30, 45, 60, and 75. The primary outcome is the absolute change in HbA1c from baseline (Day 0) to Day 90. Secondary outcomes include changes in diabetes self-care activities (SDSCA-TR), diabetes-related distress (PAID-5-TR), and body mass index (BMI) from Day 0 to Day 90. |
VELI BİLEN; | 2025-12-31 |
| 62 | Assessment of Differences in Body Composition, Physical Fitness, and Thermoregulatory Response to Incremental Exercise in Young Boys With Type I Diabetes and Healthy Soccer Players PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to assess differences in body composition, exercise capacity, and thermoregulation between young soccer players with type 1 diabetes and their healthy peers. Real-time glycemic monitoring during exercise will provide insights for developing effective diabetes management strategies, enhancing athletes’ health and performance. |
PAWEŁ KORMAN; | 2026-01-27 |
| 63 | The Effect of Educatıonal Program and Remınder Mobıle Applıcatıons on Foot Self-Care Behavıors, Dıabetes Management Self-Effectıveness and Qualıty of Lıfe in Type 2 Dıabetes: A Randomızed Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes mellitus is a metabolic disease with systemic, acute and chronic complications whose prevalence is increasing all over the world and in our country (Satman et al. 2013). The prevalence of diabetes all over the world and in Turkey is increasing day by day and this situation is becoming an important public health problem (Aytemur and Vardar İnkaya 2022). Diabetic foot is an important complication that causes organ loss, affects individuals mentally, physically, socially and economically, and requires frequent hospitalization and surgical intervention (Danmusa et al. 2016, Kalaycı et al. 2020). In the prevention of diabetes, … |
SELMA SAHIN; | 2026-03-05 |
| 64 | Efficacy and Safety of Medtronic 780G Automated Insulin Delivery System in Adults With Type 1 Diabetes and Gastroparesis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the efficacy and safety of Medtronic 780G automated insulin delivery system in adult persons with type 1 diabetes and gastroparesis. |
VIRAL N. SHAH; | 2026-02-18 |
| 65 | A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate The Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years. |
MOHAMMAD ARYANPURE; | 2026-03-20 |
| 66 | A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Baricitinib to Preserve Beta Cell Function in Participants Newly Diagnosed With Type 1 Diabetes Aged ≥1 to <36 Years PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks. |
ANDREA STECK; | 2026-03-27 |
| 67 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Dose-Finding Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin, with or without a steady dose of an SGLT2 inhibitor, for at least 90 days. The study is being done at multiple medical centers. Participants are assigned by chance (randomized) to different groups, and neither the participants nor the study staff know which group they’re in (double-blind). The groups are compared side by side (parallel), … |
CORXEL PHARMACEUTICALS | 2026-01-14 |
| 68 | Fecal Microbiota Transplantation Intervention on Microbiota Composition and Insulin Sensitivity in Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the trial is to investigate the effect of fecal microbiota transplantation versus placebo on glycemic metabolism and gut microbiota composition in people with type 2 diabetes. |
HENRIK HOLM THOMSEN; | 2026-02-19 |
| 69 | A Digital Mindfulness and Biometric Feedback Application for Young Adults With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to test a mindfulness app called Calm Health among young adults with type 1 diabetes or other absolute insulin deficiency diabetes. Mindfulness is the practice of being aware of your thoughts and feelings in the moment without judgment or negative reaction. All participants will receive mindfulness guidance and personalized feedback about the relationship among your mindfulness, blood sugar, stress, and sleep. |
LAURA M NALLY; | 2026-02-09 |
| 70 | GATEWAY: Safety Evaluation of The MiniMed™ NMX8-AID System in Children and Adults Living With Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to check that a new insulin pump, called NMX8, is safe when used with a continuous glucose monitoring sensor called Disposable Sensor 5 in people with diabetes. The study will include people with Type 1 diabetes who are 7-85 years old and people with Type 2 diabetes who are 18-85 years old. Patients will use their current therapy while also wearing the DS5 for up to 40 days. During this time, … |
JAMES THRASHER; | 2026-02-11 |
| 71 | Estimating Insulin Sensitivity Fluctuations Across Pregnancies With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators want to learn how the body’s response to insulin changes during pregnancy in people with Type 1 Diabetes. In this study, the investigators will look at information from people who used a Dexcom continuous glucose monitor (CGM) and a Tandem insulin pump while they were pregnant. Participants will fill out an online survey and agree to share their device data. The investigators will use this information to see how insulin sensitivity changes from three months before pregnancy to six months after the baby is born. |
JACOPO PAVAN; | 2026-03-02 |
| 72 | Platelet Indices Changes in Type 2 Diabetes Mellitus and Their Relationship With Inflammatory Markers PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study examines changes in platelet indices in people with type 2 diabetes compared to healthy people. It checks if these changes relate to inflammation markers (like hs-CRP) and blood sugar control. Participants get routine blood tests during one clinic visit at Assiut University Hospitals. No treatments or extra procedures are involved. |
HAGAR HASSAN MOSTAFA AHMED; | 2026-01-23 |
| 73 | Study on The Intervention Effect of Denosumab on High-Risk Patients With Osteoporotic Fractures in Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will conduct a randomized controlled trial targeting patients with type 2 diabetes and a high risk of fractures. The aim is to evaluate the intervention effect of denosumab combined with edilossobulin on patients with a high risk of osteoporotic fractures due to type 2 diabetes, as well as its impact on bone density, bone turnover indicators, the risk of new fractures, and the risk of hypocalcemia. This will provide scientific evidence for clinical diagnosis and treatment, and offer important clinical research evidence for formulating national health policies. |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2026-01-21 |
| 74 | A Multicenter, Randomized, Double-blind, Phase 3 Study to Evaluate Efficacy and Safety of HM11260C in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin and Dapagliflozin PF:3 Related Papers Related Patents Related Grants Related Experts |
SUNG RAE KIM; | 2026-01-30 |
| 75 | Time Restricted-eating and Metabolic Health in Patients With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Time-restricted eating – where no food is consumed over a period of time – has been shown to promote weight loss and improve cardio-metabolic function. In individuals with type 2 diabetes, it is also been shown to improve glucose control. The investigators propose a randomized controlled trial to determine whether time-restricted eating is an effective therapeutic strategy that can preserve pancreatic beta-cell function and improve glycemic control early in participants with type 2 diabetes. |
MOUNT SINAI HOSPITAL CANADA | 2026-02-11 |
| 76 | Preoperative Hippocampal Glucose Metabolism Levels and The Risk of Postoperative Delirium in Older Patients With Type 2 Diabetes: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: To investigate the association between preoperative hippocampal glucose metabolism levels and the risk of postoperative delirium (POD) in elderly patients with type 2 diabetes (T2DM), and to provide a prospective neuroimaging biomarker for identifying high-risk populations. Methods: This prospective cohort study plans to enroll 154 elderly T2DM patients scheduled for liver tumor resection at the First Medical Center of Chinese PLA General Hospital. Baseline cognitive function will be assessed using the Mini-Mental State Examination (MMSE) one day before surgery. Hippocampal glucose metabolism will be quantitatively evaluated by measuring the mean standardized uptake value (SUVmean) of bilateral hippocampi using ¹⁸F-FDG PET/CT. POD will be assessed twice daily from postoperative days 1 to 7 using the 3-Minute Diagnostic Interview for CAM (3D-CAM). The correlation between preoperative hippocampal SUVmean and POD incidence will be analyzed using univariate and multivariate logistic regression models. The predictive performance will be evaluated by constructing receiver operating characteristic (ROC) curves. Furthermore, the relationship between a peripheral insulin resistance marker (the triglyceride-glucose index, TyG index) and hippocampal metabolism levels will be analyzed. Significance: This study aims to determine whether impaired preoperative hippocampal metabolism serves as an independent risk factor for POD. The findings are expected to provide a prospective functional neuroimaging biomarker for the early warning of POD and offer a theoretical basis for developing precise prevention strategies targeting cerebral metabolic abnormalities. This will facilitate the application of neuroimaging techniques in the field of perioperative brain dysfunction monitoring. |
WEIDONG MI; | 2026-01-27 |
| 77 | How Can We Prevent The Underdiagnosis of Diabetes and The Undertreatment of Known Diabetes in Patients With Inflammatory Arthritis Treated With Sulfasalazine? PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to examine whether the blood test Hemoglobin A1c (HbA1c) gives an accurate picture of blood glucose levels in patients with inflammatory arthritis who are treated with sulfasalazine. HbA1c is widely used to diagnose and monitor diabetes, but sulfasalazine can shorten red blood cell lifespan and thereby lower HbA1c values independently of actual glucose levels. This may lead to underdiagnosis of diabetes in patients who develop diabetes during sulfasalazine treatment, … |
KLAVS WÜRGLER HANSEN; | 2026-02-18 |
| 78 | Preventing Type 2 Diabetes Following Gestational Diabetes: Implementation Mapping for A Multilevel Breastfeeding Support Strategy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators will use implementation methods to develop better breastfeeding support for patients with gestational diabetes as a way to prevent type 2 diabetes. |
ADRIENNE HOYT-AUSTIN; | 2026-02-02 |
| 79 | The Impact of Integrated Oral Care Intervention Provided By Endocrinologists on Oral Health and Well-being in Diabetes Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes patients commonly experience dry mouth also known as xerostomia which can affect eating speaking oral health and overall quality of life. This study evaluates whether simple oral care actions delivered by endocrinologists during routine diabetes clinic visits can improve dry mouth symptoms and oral health related quality of life. Endocrinologists will be trained to screen for dry mouth provide brief counseling prescribe saliva substitutes and refer patients to dental services when needed. Adult patients with diabetes and symptoms of dry mouth will be followed before and after the intervention to assess changes in xerostomia severity and oral health outcomes. The study will also explore barriers and facilitators to integrating oral health care into routine diabetes management in Pakistan. |
MAHDIA BABAK; | 2026-02-20 |
| 80 | Families Implementing Good Health Traditions for Life PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will provide evidence for the utility of using a community-engaged research approach to implement a tailored, family-oriented adaptation of the Diabetes Prevention Program that will have positive effects on risk factors associated with type 2 diabetes morbidity and mortality among Black families in a Southwest Georgia community. |
RAKALE COLLINS QUARELLS; | 2026-03-02 |
| 81 | Evaluation of The Psychometric Properties of The Turkish Version of The Hypoglycaemia Self-Care Behaviour Scale PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to validate the validity and reliability of the Hypoglycaemia Self-Care Behaviour Scale, developed to assess hypoglycaemia self-care behaviours in patients with type 2 diabetes, through a prospective cross-sectional study. |
SEMANUR BILGIÇ; | 2026-01-05 |
| 82 | Evaluation of A Novel Telemedicine Clinic for Patients With DM2 on Multiple Daily Insulin (MDI) Regimens PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Almost 40% of veterans have diabetes, the proposed research may improve clinical care among veterans with diabetes. In this application we are going to examine whether utilizing Smart Insulin pens (SIPs) with CGMs and telemedicine is a better tool for managing diabetes compared to traditional insulin pens, CGMs and telemedicine, leading to improved blood sugar control and better clinical outcomes. |
ILIAS SPANAKIS; | 2026-02-10 |
| 83 | Effects of LP-LDL® on Lipid Metabolism, Glycemic Control, Inflammatory Markers, and Cognitive Function in Individuals With Prediabetes and Diabetes Mellitus (Type 1 and Type 2) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized, double-blind, placebo-controlled clinical trial investigates the effects of the probiotic LP-LDL® (Lactobacillus plantarum ECGC 13110402) on lipid metabolism, glycemic control, inflammatory biomarkers, and cognitive function in adults with prediabetes, type 1 diabetes, or type 2 diabetes who also exhibit elevated cholesterol or triglyceride levels. A total of 210 participants will be enrolled across three parallel sub-studies: * Type 1 diabetes (n = 76) * Type 2 diabetes (n = 54) * Prediabetes (n = 80) Participants will be randomized 1:1 to receive LP-LDL® or matching placebo once daily for 12 weeks, … |
HIVA ALIPOUR; | 2026-01-29 |
| 84 | The Effect of Education Provided to Children With Type 1 Diabetes Using Gamification Methods on Health Literacy and Quality of Life: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: This study aims to examine the effect of education provided through gamification methods on health literacy and quality of life in children diagnosed with type 1 diabetes (T1DM). Materials and Methods: The study is planned as a randomized controlled trial with a pre-test-post-test, parallel design (1:1). The data for the study will be collected between January and April 2026 from patients diagnosed with type 1 diabetes mellitus at the Ankara Etlik City Hospital Pediatric-2 Endocrinology Service. The sample size has been determined to be 52 patients, with 26 in each of the experimental and control groups, … |
GÜLFIDAN BAŞER; | 2026-02-13 |
| 85 | Examining The Effect of Endogenous Glucagon-like Peptide-1 on Glucagon Secretion in Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Type 1 diabetes is a serious and burdensome disease that carries the risk of severe complications and premature death, partly due to low blood sugar, also called hypoglycaemia. This is a constant threat, as individuals with type 1 diabetes lack the body’s natural safeguard against low blood sugar: the hormone glucagon, which is normally released from the pancreas. Recent research in mice suggests that this missing safeguard may be due to an imbalance in the hormones released from different cells in the pancreas. More specifically, … |
ASGER LUND; | 2026-01-28 |
| 86 | Extension for Community Health Outcomes (ECHO) Diabetes Federally Qualified Health Centers (FQHCs) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Extension for Community Health Outcomes Diabetes FQHC will provide tele-education to primary care providers (PCP) in Federally Qualified Health Centers in the U.S. using the hub and spoke training model established in the Project ECHO model. Participating FQHCs (called spokes) will receive twice monthly tele-education sessions delivered by UF’s hub team in a 6-month program. The program will be evaluated using pre/posttest provider-level surveys and center-level aggregate data in a stepped-wedge trial design with 3 cohorts of FQHCs. The primary outcomes are the proportion of people \>9% HbA1c and technology use (CGM and insulin pump). |
ASHBY F WALKER; | 2026-02-18 |
| 87 | A Phase II, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy and Tolerability of GL0034 Among Type II Diabetes Mellitus Subjects Who Are Obese or Overweight With Weight-related Comorbidities PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase II, randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of GL0034 among type II diabetes mellitus subjects who are obese or overweight with weight-related comorbidities. Subjects will be put on either one of the four treatment arms (GL0034, once a week, subcutaneous injection) or placebo arm (once a week, subcutaneous injection) following initial dose-up titration that takes up to approximately 20 weeks. The primary end point is change in HbA1c levels from baseline (Week 0) to Week 36 following treatments in all participants. |
SUN PHARMACEUTICAL INDUSTRIES | 2026-03-18 |
| 88 | Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care when ordered by primary care providers. The main question it aims to answer is: Can the iLet BP by deployed in primary care settings to adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes)? Researchers will compare 13-weeks of iLet BP use to routine care to see if iLet BP use has a greater reduction in HbA1c compared to13-weeks of routine care. Participants will: Use the iLet BP for 13-weeks or continue their routine care Be trained to use the study devices or continue their routine care Complete a virtual screening visit, mid-period follow up calls and a final visit Complete baseline CGM collection Complete surveys and fingerstick a1c blood tests Routine care participants will have the option to complete an observational extension phase where they will wear the iLet BP for 13-weeks |
SEAN OSER; | 2026-04-02 |
| 89 | Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will evaluate the effects of oral semaglutide in combination with topical corticosteroid/calcipotriol on clinical outcomes and metabolic inflammation in patients with plaque psoriasis and overweight/obesity and/or type 2 diabetes mellitus. A total of 62 participants will be randomized to receive either semaglutide plus topical corticosteroid/calcipotriol or placebo plus topical corticosteroid/calcipotriol for 12 weeks. Clinical efficacy will be assessed using the Psoriasis Area and Severity Index (PASI), and quality of life will be evaluated using DLQI, PROMIS-29, and EQ-5D-5L. Systemic inflammatory markers will also be measured to assess metabolic inflammation. |
JORGE VALDESPINO VALDES; | 2026-02-11 |
| 90 | A Study to Evaluate The Effect of Fasting Duration and Temporary Withholding of Tirzepatide on Retained Gastric Contents Using Gastric Ultrasound in Participants With Type 2 Diabetes Mellitus and Participants With Overweight or Obesity Without Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate how fasting and stopping the use of tirzepatide affects the amount of food and drink that stays in the stomach after a meal. Ultrasound will be used to check the stomach content after a test meal. |
NOEL VARGHESE; | 2026-03-04 |
| 91 | DiaMester: E-health Lifestyle Program for Improved Self-management and Remission of Type 2 Diabetes – A Pilot RCT PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This registration covers a pilot for a 3-armed parallel-group randomized controlled trial (RCT) that will evaluate the efficacy of DiaMester, a Norwegian e-health programme designed to improve self-management and induce clinically meaningful weight loss, and thereby potential remission in adults with type 2 diabetes (T2D). |
ANNE-MARIE AAS; | 2026-01-23 |
| 92 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to demonstrate that KAI-9531 subcutaneous (SC) injection once weekly is superior to placebo on: * Percent change in body weight * Change in hemoglobin A1c (HbA1c) |
KAILERA | 2026-03-31 |
| 93 | A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Baricitinib to Delay Stage 3 Type 1 Diabetes in At-risk Participants Aged ≥1 to <36 Years PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to find out if baricitinib can delay the onset of clinical type 1 diabetes (T1D) in people who are at high risk to develop T1D. Participation in the study will last up to approximately 5 years. |
LARRY DEEB; | 2026-03-20 |
| 94 | Assessment of Carbohydrate Content Estimation Among Sohag University Students With Type 1 Diabetes Mellitus and Their Glycemic Control PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study assesses carbohydrate counting knowledge and its impact on glycemic control among Sohag University students with type 1 diabetes mellitus. A structured educational intervention will be delivered, followed by reassessment after three months. |
ELZAHRAA ABDELLATIF MOHAMED; | 2026-01-22 |
| 95 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ANGPTL3 Inhibition With Either Small-Interfering RNA Alone or in Combination With An ANGPTL3 Antibody in Participants With Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is researching experimental drugs called ALN-ANG3 and evinacumab (called study drugs). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times |
REGENERON PHARMACEUTICALS | 2026-03-17 |
| 96 | Clinical Effect of Swedish Massage Versus Adjuvant Yoga on Blood Glucose Level in Children With Type 1 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Swedish massage (SM) and yoga are complementary non-pharmacological techniques that have recently been used in managing chronic disorders such as type 1 diabetes mellitus (T1DM). Both techniques play an important role in reducing stress, which contributes to lowering blood glucose levels in children with T1DM. Objective: To investigate the effect of Swedish massage versus children’s yoga exercises on blood glucose levels of children with T1DM |
MOHAMED SAIED ZIDAN; | 2026-02-02 |
| 97 | The Impact of Ramadan Experiences on Treatment, Psychological and Glycemic Control Levels, and Adherence in Individuals With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to examine the effects of fasting during Ramadan on treatment adherence, psychological adjustment, and glycemic control in individuals with type 2 diabetes. While Ramadan fasting is a religious practice, it can also pose health risks such as hypoglycemia, hyperglycemia, and metabolic imbalance in individuals with diabetes. Adherence to treatment and self-care, as well as psychosocial adjustment, are crucial in the effective management of diabetes. Given that a large portion of Turkey’s population is Muslim, … |
DILAN AKTEPE COŞAR; | 2026-02-03 |
| 98 | Improving Glycemic Control Among Underserved Patients with Insulin-treated Type 2 Diabetes Through Nurse-led, App-based Behavioral Intervention PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This 12-month pilot tests a nurse-led, app-based intervention to improve diabetes self-management for low-socioeconomic status patients. It includes MyChart messing to give education, phone help on problem-solving with clinicians, and using a diabetes app to track data. The study aims to enhance self-management behaviors through health technology. |
HELEN NC CHEN PHD; | 2025-02-07 |
| 99 | Increasing The Uptake of DSMES Program and Addressing Social Needs in Low-Income Vulnerable Immigrants PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate a multi-level approach to improve diabetes control via access to social service supports and online, culturally-tailored diabetes self-management education and support (DSMES) videos among a community of primarily Chinese and Latino/a immigrants. The study aims to assess patient uptake, provider adoption, and INSPIRE program acceptability, appropriateness, feasibility, fidelity, penetration/reach, and maintenance. |
NADIA ISLAM; | 2025-12-22 |
| 100 | Feasibility and Effectiveness of Diabetic Retinopathy Screening Using Artificial Intelligence in Children With Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed project is a clinical intervention trial testing the feasibility and effectiveness of diabetic retinopathy screening evaluated by artificial intelligence (AI) based software in children with type 1 diabetes (CwD). Another novel method, the confocal microscopy of the retina will be used to assess the early stages of diabetic neuropathy. In parallel, … |
VIT NEUMAN; | 2025-09-17 |
| 101 | Active Anti-diabetic Treatment Plus Chemotherapy for Metastatic Pancreatic Cancer Related Diabetes Mellitus (Type 3c) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the efficacy of anti-diabetic treatment on improving the overall survival for metastatic pancreatic cancer patients complicated by diabetes receiving gemcitabine and nab-paclitaxel chemotherapy. |
GUOPEI LUO; | 2025-12-15 |
| 102 | A Phase II, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety, and Tolerability of ASC30 Tablets in Participants With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized, double-blind, placebo-controlled Phase II study is designed to evaluate the efficacy, safety, and tolerability of ASC30 oral tablets formulation in participants with Type 2 Diabetes Mellitus |
ASCLETIS PHARMA CHINA CO | 2026-01-07 |
| 103 | Clinical Study of Non-invasive Blood Glucose Detection Technology Based on Raman Spectroscopy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes is a chronic metabolic disease that is widely prevalent globally, with its incidence rate continuously increasing, posing significant challenges to patient health and public health systems. In China, the number of diabetes patients ranks first in the world, with an adult prevalence rate as high as 12.8%. The core of diabetes management is blood glucose control. However, traditional finger-prick blood testing methods are inconvenient and have low patient compliance. In recent years, non-invasive blood glucose detection technologies have become a research hotspot. Among them, optical methods, especially spectroscopy techniques, … |
BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSITY | 2025-12-31 |
| 104 | The Role of Triglyceride-glucose Index As A Predictive Marker for Insulin Resistance in Pre Diabetic Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the role of the triglyceride-glucose (TyG) index as a predictive marker for insulin resistance in pre-diabetic patients with chronic kidney disease (CKD), and to investigate its potential utility as a simple, non-invasive alternative to traditional insulin resistance assessment methods. |
EMAN OSAMA AHMED ABD_ELSAMEA; | 2025-12-12 |
| 105 | Evaluating The Efficacy of High-Protein Diabetes Specific Formula (HP-DSF) on Body Composition in Overweight/Obese Patients With Type 2 Diabetes Treated With Incretin Mimetic Drugs PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A randomized clinical study to assess the efficacy of a high-protein diabetes specific formula (HPDSF) on lean muscle mass in overweight and obese patients with type 2 diabetes who are initiating treatment with incretin-mimetic drugs. |
OSAMA HAMDY; | 2026-01-30 |
| 106 | A U.S. Pilot Human Investigation of RadiofrEquency Vapor Ablation System to Evaluate Safety, TOleRability, and Effectiveness for Proximal Intestinal Mucosal Ablation in Patients With Type 2 Diabetes Mellitus (RESTORE-1 Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the safety, tolerability and effectiveness of RF vapor ablation of the proximal intestinal mucosa. This study will test the hypothesis that RF vapor ablation will result in improvement in glycemic parameters, without Serious Adverse Events (SAE) or Unanticipated Adverse Device Effects (UADE). |
NICHOLAS SHAHEEN; | 2026-01-21 |
| 107 | Evaluation of Endoscopic Band Ligation for Treatment of Type 2 Diabetes: A Single-Center Interventional Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a pilot clinical study evaluating the safety and feasibility of Endoscopic Band Ligation (ENDOBAND-DM) applied to the second through fourth parts of the duodenum – from just distal to the ampulla of Vater to the ligament of Treitz – in patients with type 2 diabetes mellitus (T2DM). The goal is to induce mucosal remodeling in this duodenal segment, potentially enhancing gut hormone signaling and improving glycemic control. Participants will be monitored for changes in HbA1c, fasting glucose, and insulin sensitivity over 6-12 months. |
MOHAMED ABEID; | 2025-08-15 |
| 108 | Experience With The Use of Continuous Glucose Monitoring (CGM) Devices in People With Type 2 Diabetes Mellitus Related Papers Related Patents Related Grants Related Experts Highlight: Background: In recent years, diabetes management has evolved with the introduction of continuous glucose monitoring (CGM) devices. Some qualitative studies have been conducted to assess the experiences of patients with type 2 diabetes mellitus (T2DM) using CGM devices, but none have been conducted in a Mediterranean country. Furthermore, there are differences in the amount of time study participants used the CGM device, ranging from 14 days to 6 months, and in some studies, … |
SERGI RODRÍGUEZ SOLER; | 2025-07-09 |
| 109 | Construction of A Precision and Individualized Management Model for Diabetes With Integrated Traditional Chinese and Western Medicine PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This project will leverage a large-scale cohort of early-onset type 2 diabetes patients to conduct innovative prospective clinical research. By integrating traditional Chinese medicine diagnostic information, clinical data, laboratory results, continuous glucose monitoring, genetic information, multi-omics data, and multi-modal monitoring data, and utilizing advanced data analysis methods such as deep learning, the project aims to establish a comprehensive monitoring, precise classification, and personalized diagnosis and treatment model-a holistic management approach integrating traditional Chinese and Western medicine for early-onset type 2 diabetes. This initiative is expected to enhance the management of early-onset type 2 diabetes, … |
XINHUA XIAO; | 2025-12-29 |
| 110 | A Multi-centre, Prospective, Open-label, Single-arm, Non-interventional, Regulatory Post Marketing Surveillance (rPMS) Study of Rybelsus® (Oral Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in Korea PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to assess the safety and effectiveness of Rybelsus initiated according to label in adults with Type 2 Diabetes Mellitus (T2DM) under routine clinical practice conditions. Participants will get Rybelsus as prescribed by study doctor. The study will last for about 26 weeks. |
NOVO NORDISK | 2025-12-05 |
| 111 | Impact of PharmaTE Trial on Glycemic Control, Diabetes Knowledge, Medication Adherence and Quality of Life in Type 2 Diabetes Patients: A Mixed-Method Study Protocol PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to find out whether a pharmacist-led tele-educational program (PharmaTE trial) can help people with type 2 diabetes manage their condition better. The main questions this study aims to answer are: 1. Does the PharmaTE trial improve blood sugar control (HbA1c levels)? 2. Does it help patients better understand their condition? 3. Does it increase how well patients follow their medication schedule? 4. Does it improve the quality of life for patients with type 2 diabetes? 5. Is this type of tele-education program feasible and acceptable for patients? Participants will: Be randomly placed into one of two groups: Intervention group: Receive five virtual education sessions with a clinical pharmacist over the phone or via Zoom (each lasting 20-30 minutes), in addition to their usual diabetes care. Control group: Continue receiving standard diabetes care from their healthcare team without the additional pharmacist-led sessions. Complete assessments at the beginning and end of the study. These include: A blood test for HbA1c , Questionnaires on diabetes knowledge, medication adherence, and quality of life Some participants in the intervention group will be invited for interviews after the sessions to share their experiences and opinions about the program. Who can join? Adults aged 18-65 with uncontrolled type 2 diabetes (HbA1c \> 7%), receiving care at Ibrahim Bin Hamad Obaidullah Hospital in Ras Al-Khaimah, who speak Arabic and can provide consent. |
RABIA HUSSAIN; | 2025-07-02 |
| 112 | A Comparison of Effectiveness, Safety, and Cost-effectiveness of Dapagliflozin and Empagliflozin in Patients With Type 2 Diabetes Mellitus and High Body Mass Index (BMI): A Randomized Controlled Trial at A Tertiary Care Hospital in Central India PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the effect of two drugs used to treat diabetes, that is, Dapagliflozin and Empagliflozin on HbA1c (which is an indicator of blood sugar over the last 3 months) body weight, liver and kidney function, blood pressure, and overall cost-effectiveness in patients with type 2 diabetes and high body mass index (23kg/m2). The results will help us determine which drug is more effective, safer, and economical for Indian patients and improve future treatment options. |
BHAVYA BHAVYA; | 2025-12-31 |
| 113 | Dysautonomia in Children With Type 1 Diabetes: DysDiab Single-center Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Some physiological factors, such as physical activity, or pathological factors, such as sepsis or diabetes, are known to modulate the overall autonomic activity and the individual’s intrinsic capacity to regulate their sympathetic and parasympathetic balance. These conditions can alter the physiological autonomic balance, sometimes with positive consequences on the FC-breathing control and blood pressure adjustment, depending on the individual’s position and the status of blood volume, but sometimes with deleterious effects, … |
CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE | 2026-03-06 |
| 114 | Phase 1 Randomized Clinical Trial of Arginine Hydrochloride Administration to Reduce Duration of Diabetic Ketoacidosis in Patients With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetic ketoacidosis (DKA) is increasingly recognized in adults with ketone-prone type 2 diabetes. In many of these patients, the pancreas can still make insulin but becomes temporarily stunned during severe, prolonged high blood sugar. Arginine is a naturally occurring amino acid that can trigger the pancreas to release its own insulin when glucose is high. It is FDA-approved for other uses and has been given intravenously for decades with a strong safety record. Whether a single arginine infusion given early during DKA can safely boost the body’s insulin and speed recovery has not been tested. This randomized, double-blind, placebo-controlled, … |
DAVID K CARROLL; | 2026-02-12 |
| 115 | Islet Autoantibody Early Detection in At-risk Children/Adolescents to Predict Type 1 Diabetes: A Cohort Study in Gulf Countries PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this research is to identify pre-symptomatic Type 1 Diabetes (T1D) in young children and adolescents who have first degree relatives with T1D. This protocol has been developed to address the growing need for standardized T1D screening, monitoring, and data collection in alignment with international recommendations. The study’s estimated duration is 13 months and will consist of two visits: Visit 1 (screening visit) and Visit 2 (confirmatory visit). |
SANOFI | 2026-02-19 |
| 116 | Remission of Diabetes With Lifestyle Intervention for Malaysian Type 2 Diabetes Mellitus Patients (ReDiaL-MY) – An Open Label, Randomised Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effectiveness of structured lifestyle intervention to induce remission of Type 2 Diabetes Mellitus (T2DM) among Malaysian adults. The study will also assess the feasibility of implementing this intervention within Malaysian primary and specialist care settings. The study will also examine the economic impact of the TDR intervention through a cost-effectiveness analysis conducted from a societal perspective. Researchers will compare intensive lifestyle intervention to the usual clinical care. It is hypothesised that Malaysian adults with T2DM who receive the structured lifestyle intervention will demonstrate a significantly higher rate of diabetes remission compared to those receiving usual care. Furthermore, participants in the intervention group are expected to achieve greater mean weight loss, with a higher proportion attaining a sustained weight loss of at least 10 kilograms, relative to the usual care group. The lifestyle intervention is also anticipated to result in superior glycaemic control, as measured by reductions in glycated haemoglobin (HbA1c), and to be more cost-effective in achieving diabetes remission and reducing long-term healthcare utilization. |
WINNIE CHEE SIEW SWEE; | 2026-03-27 |
| 117 | A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate The Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, and Type 2 Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks. |
NOVA LAW; | 2026-03-20 |
| 118 | Multicenter Study on Early Arterial Changes in Prediabetic Patients Evaluated By Ultra-High-Frequency Ultrasound（MAP-UHF Study） PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Ultra-high frequency ultrasound technology (20-100 MHz) can clearly distinguish the arterial intima and media layers, and can simultaneously meet the needs of examining the carotid artery and peripheral arteries, enabling earlier and more accurate detection of vascular damage in pre-diabetic individuals. Therefore, this study aims to establish the normal values of arterial intima and media thickness measured by ultra-high frequency ultrasound in healthy Chinese adults, providing quantitative reference for the early diagnosis, severity assessment, and efficacy observation of arterial diseases. Meanwhile, by applying ultra-high frequency ultrasound, … |
CHUNYAN MA; | 2025-12-09 |
| 119 | Efficacy and Safety of IGlarLixi Versus Standard of Care in A Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral Agents-a Pragmatic Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a prospective, open-label, multicenter, parallel-group, positive-controlled, and pragmatic randomized clinical trial (pRCT). It will compare the efficacy and safety of iGlarLixi versus standard of care in adult T2DM patients with poor glycemic control, who are using 1 to 3 OADs in a real-world clinical practice setting. A total of 1,316 subjects from approximately 40 research centers in China will be randomly assigned in a 1:1 ratio to one of the following treatment groups: Group 1: iGlarLixi for blood glucose control; and Group 2: Standard of care for diabetes (basal insulin or premixed insulin, … |
SHANGHAI ZHONGSHAN HOSPITAL | 2025-12-29 |
| 120 | Achieving Health in Emerging Adults With Diabetes (AHEAD) Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to determine whether the Achieving Health in Emerging Adults with Diabetes (AHEAD) Program helps emerging adults with type 1 diabetes improve their blood glucose management during the transition from pediatric to adult care. Participants will be randomized to receive Usual Care or the AHEAD Program, which provides tailored support to emerging adults to build autonomy and competence to facilitate independent diabetes management. Researchers will compare changes in glycemia and participant-reported outcomes between groups. |
FAISAL MALIK; | 2025-12-30 |
| 121 | DPP4 Inhibitor on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes Mellitus (DISC-DM): Multicentre, Double Blind, Randomised, Placebo Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Post-stroke cognitive impairment (PSCI) increases the risk of disability and mortality in stroke patients, thereby exacerbating the disease burden of stroke. Type 2 diabetes is a major risk factor for PSCI, and stroke patients with type 2 diabetes have a higher risk of developing PSCI. Despite the high incidence and severe impact of PSCI, effective intervention methods are still lacking. Identifying safe and effective drugs to improve cognitive function in stroke patients and reduce the risk of PSCI, especially for those with type 2 diabetes, … |
YIFANG ZHU; | 2025-11-21 |
| 122 | Feasibility of REAL-Fam to Support Diabetes Self-Management, Family Participation, and Child Health PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if the REAL-Fam occupational therapy intervention is feasible to study in a larger-scale randomized controlled trial. It will also seek to understand how the intervention influences how a rural family participates in and manages their child’s type 1 diabetes, their family quality of life, and the child’s health outcomes. The main questions it aims to answer are: * Primary Aim 1: Evaluate the recruitment capability, participant inclusion criteria, assessment selection and process, … |
VANESSA JEWELL; | 2026-01-23 |
| 123 | The Effect of Laughter Yoga on Self-management and Comfort in Type 2 Diabetes Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to examine the effect of laughter yoga on self-management skills and comfort levels in patients with Type 2 diabetes. |
BETÜL BAL; | 2025-12-09 |
| 124 | Community Health Workers Led Integrated Management of Hypertension and Diabetes in Nepal PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Hypertension (HTN) and diabetes mellitus are significant global public health challenges, contributing to 13.5% of premature deaths, 54% of incident strokes, and 47% of coronary heart disease cases (HTN), and increasing risks of cardiovascular diseases, kidney failure, and other complications (diabetes). In Nepal, HTN prevalence is 24.5% and diabetes affects 5.8% of adults (2019 Nepal STEPS Survey), with many cases undiagnosed or poorly managed, and an estimated 60% co-morbidity among diabetic individuals. Nepal’s Package of Essential Non-Communicable Diseases (PEN), implemented since 2017, targets both conditions, but multi-level barriers limit its facility-based effectiveness. This study addresses the need for cost-effective, … |
ARCHANA SHRESTHA; | 2026-03-10 |
| 125 | An Evaluation of The Omnipod® M System in Adults With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single arm feasibility study to evaluate the Omnipod M System in adults with Type 2 Diabetes with the aim to enroll to 40 participants aged 18-75 years with type 2 diabetes to have a minimum of 20 participants initiate the use of Omnipod M System and the goal of 16 participants completing the 6-week treatment period. |
INSULET | 2026-03-31 |
| 126 | A Placebo-Controlled, Double-Blind, Randomized, Phase 3 Study to Evaluate The Effect of Obicetrapib 10 Mg and Ezetimibe 10 Mg Fixed-Dose Combination or Obicetrapib 10 Mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes And/or Metabolic Syndrome (RUBENS Trial) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will be a placebo-controlled, double-blind, randomized, Phase 3 study to evaluate the efficacy, safety, and tolerability of obicetrapib 10 mg, both as a fixed-dose combination (FDC) with ezetimibe 10 mg and as monotherapy, on top of guideline-recommended lipid-lowering therapy in patients with metabolic syndrome and/or Type 2 Diabetes Mellitus. |
NEWAMSTERDAM PHARMA | 2026-03-10 |
| 127 | Characterisation of A Population of Adults Suffering From Cystic Fibrosis in A Belgian Center of Reference and Evaluation of The Impact of Diabetes and CFTR Modulators on Respiratory Function, Nutritional Status and Quality of Life PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This research project aims to better understand the consequences of diabetes on the quality of life, respiratory function, and nutritional status of patients with cystic fibrosis followed at a Belgian reference center and to compare the quality of life of patients with cystic fibrosis depending on whether or not they have diabetes. |
AGNES BURNIAT; | 2026-03-02 |
| 128 | Individualized Early Diagnosis and Treatment System of Gestational Diabetes Mellitus (GDM) Based on New Continuous Glucose Monitoring (CGM) Technology PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Gestational diabetes mellitus (GDM), as the most common metabolic complication of pregnancy, poses a serious threat to maternal and fetal metabolic health. However, current GDM diagnosis faces several problems such as static, single-point, cumbersome to operate and delayed diagnosis, highlighting an urgent need to establish an individualized system for early prediction, diagnosis, and intervention. This project aims to develop a mother-child cohort covering pregnancy and the perinatal period to propose early diagnostic criteria for GDM based on continuous glucose monitoring (CGM) technology, as well as developing clinically applicable AI-based tools for analyzing and interpreting CGM data, … |
XINHUA XIAO; | 2025-12-29 |
| 129 | Twiist Postmarket Surveillance Study in Adults and Youth With Type 1 Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this surveillance study is to collect real-world data on adults and youth with type 1 diabetes (T1D) using twiist(TM) for insulin delivery. |
DEKA RESEARCH AND DEVELOPMENT | 2026-01-21 |
| 130 | An Observational Study on The Risk of Adverse Maternal and Infant Outcomes Associated With Respiratory Viral Infections Before and During Early Pregnancy PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Adverse pregnancy outcomes (APOs) are a collection of conditions that have short-term and long-term effects of complications related to pregnancy and childbirth on pregnant women and their fetuses, including hypertensive disorders of pregnancy, gestational diabetes, preterm birth, large for gestational age, among others. Nearly 30% of all women experience an adverse pregnancy outcome during their reproductive years. Although, respiratory viral infections with epidemic and pandemic potential pose an omnipresent threat to public health, research focusing specifically on the maternal-infant population remains relatively scarce. Studies conducted in USA found that among pregnant women infected with influenza, … |
MEI KANG; | 2025-12-02 |
| 131 | Interventional Study Evaluating The Use of COVER PATCH CAPTEUR PROTECT Support Solutions in Patients Living With Diabetes: A Prospective, Randomized, Controlled, Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this clinical trial is to evaluate whether the COVER PATCH adhesive patch can improve the adhesion of continuous glucose monitors (CGMs). CGMs provide continuous blood sugar readings throughout the day and night, providing valuable data to help individuals manage their diabetes more efficiently. Many people face difficulties in keeping their CGM sensor in place. Factors such as sweat, physical activity, heat, skin creams, and swimming can cause the sensor to fall off prematurely, … |
KÉVIN PERGE; | 2026-03-18 |
| 132 | Optimizing Care to Prevent Diabetes and Promote Cardiovascular Health Among Younger Adults With Severe Mental Illness PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: People with serious mental illness have high risk for type 2 diabetes due to multiple risk factors, including the metabolic side effects of psychotropic medications that are used to treat these conditions. Type 2 diabetes is preventable through lifestyle and pharmacological interventions, but many people with serious mental illness do not receive regular screening for type 2 diabetes risk. In many health care settings, … |
ESTI ITURRALDE; | 2026-02-27 |
| 133 | A Study Investigating Clinical Comparability of Two Formulations of Oral Semaglutide in Japanese Participants With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to find out if the new tablet formulation oral semaglutide D is equally safe and effective as the approved oral semaglutide for treating Japanese people with type 2 diabetes. Participants will receive either oral semaglutide D (the treatment being tested) or oral semaglutide (the comparator); which treatment a participant gets is decided by chance. Oral semaglutide is an approved tablet (a treatment used as a comparator), while oral semaglutide D is described as the new tablet formulation being tested in this study. The study will last approximately 27 weeks. |
NOVO NORDISK | 2026-03-31 |
| 134 | Künstliche Intelligenz (KI)-gestützte Früherkennung Der Diabetischen Retinopathie (FUNDUS-KI) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Examination of individuals with prediabetes and established diabetes for early signs of diabetic retinopathy. |
UNIVERSITY HOSPITAL TUEBINGEN | 2026-02-10 |
| 135 | Relationship Between Red Cell Distribution Width (RDW) and HbA1C in Patients With Type 2 Diabetes Mellitus After Glycemic Control PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes mellitus (DM) is an epidemic disease, with approximately 463 million persons diagnosed with it. Of those, 90% are patients with type 2 DM (T2DM). Some estimates indicate that 700 million cases of DM will be reported in 2045. T2DM develops due to insulin resistance, leading to reduced insulin secretion. DM has a number of associated complications, such as nephropathy, neuropathy, and cardiovascular disease. |
ASMAA NADY HUSSEIN; | 2025-08-15 |
| 136 | Assessment of Non Vascular Risk Factors for Severity of Diabetic Foot Ulcers PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes mellitus is a chronic disease that occurs either when pancreas does not produce enough insulin or when the body can’t use it effectively. Diabetes mellitus include : type 1(insulin deficiency) , type 2 ( insulin resistance ) , gestational diabetes, maturity onset diabetes of the young ( MODY) , neonatal DM , wolfram syndrome, latent autoimmune diabetes in adults ( LADA ) , type 3 c diabetes, steroids – induced diabetes, … |
SHIMAA ESSAM ELDIN RSHAD MOHAMMED; | 2025-09-26 |
| 137 | The Role of Complement in Diabetic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes is a chronic condition marked by long-term elevated blood glucose levels. There are more types of diabetes; the majority of patients have type 1 or type 2 diabetes. Over long period of time, high blood sugar damages blood vessels and organs. One of the most common complications is diabetic kidney disease, which can slowly lead to kidney failure. People with this condition also have a much higher risk of heart and blood vessel diseases. Newer research shows that the immune system, especially the complement system (a group of proteins that help defend the body), … |
MIODRAG JANIĆ; | 2026-02-23 |
| 138 | CBTi for The Treatment of Insomnia in Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to learn if treating insomnia with a therapy intervention in people with type 1 diabetes will help to better control sugar levels, sleep, … |
UNIVERSITY OF ILLINOIS AT CHICAGO | 2026-01-22 |
| 139 | Diabetic Retinopathy Prevalence And Risk Factors From A Hospital – Based Cohort In Central Vietnam PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this retrospective observational study is to evaluate the prevalence and severity of diabetic retinopathy (DR) and to identify associated risk factors among patients with diabetes mellitus at Gia Dinh Family Hospital in Da Nang, Vietnam. The main questions it aims to answer are: 1. What is the prevalence and distribution of different stages of diabetic retinopathy among diabetic patients at this hospital? 2. Which clinical and laboratory factors are associated with the presence of diabetic retinopathy? |
THAO NGUYEN NGOC; | 2026-03-12 |
| 140 | Carb Control: Low-Carbohydrate Dietary Intervention for Pediatric Patients With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this project is to test the effect of a low carb diet compared to standard carb diet among adolescents with T2D over a 24-week period. |
ORTAL RESNICK; | 2025-12-08 |
| 141 | Investigation of Safety, Tolerability, Pharmacokinetic and Pharmacodynamics of Single Administrations of NNC9733-0001 in Healthy Participants and in Participants With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is testing a new medicine that might help treat people with type 2 diabetes. The study is conducted to see if the new medicine can lower high sugar levels in the blood. The purpose of the study is to see if the new study medicine is safe and how well is tolerated by the body. There will be two groups of partici-pants in this study: healthy participants and participants with type 2 diabetes. Participant will either get study medicine (NNC9733-0001) or placebo (a treatment that has no active medicine in it). Which treatment the participant gets is decided by chance. Which dose (strength) the participant get is determined by when participant enter the study. Participant will get one dose which will be injected into the area around abdomen (belly) by the medical staff. The number of injections (up to 4 injections) will depend on the group the participant is assigned to. Larger doses require multiple injections. The study will last for about 40 weeks (10 months). |
NOVO NORDISK | 2025-12-08 |
| 142 | A Phase 4 Multicenter, Randomized, Open-Label, Interventional Study With Pragmatic Elements Investigating The Effectiveness of Tirzepatide Once Weekly Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes in A Real-World Setting PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate tirzepatide within a real-world setting to assess body weight loss and incidence of type 2 diabetes in adults without diabetes who have obesity and at least one weight-related comorbid condition. Participation in the study will last about 260 weeks. |
LORNA MCCUNE; | 2026-03-19 |
| 143 | Nutritional Management of The Patient With Type 2 Diabetes at Nutritional Risk or With Malnutrition in Clinical Practice. STARLIGHT Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this observational study is to characterize the patient profile and nutritional treatment patterns of individuals with type 2 diabetes (T2D) or drug-induced diabetes who present with malnutrition, or are at risk of it, and who are prescribed a diabetes-specific oral nutritional supplement (ONS) that is high in calories and protein and contains soluble fiber. Participants will complete a series of questionnaires during visits 1 and 3. |
OUTCOMES’10 | 2026-01-28 |
| 144 | An Exploratory Randomised, Double-Blind, Placebo-Controlled Study of The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZE63-0302 in Participants With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A Phase 1b study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of multiple doses of ZE63-0302 administrated orally in T2DM patients. |
EILEAN THERAPEUTICS | 2026-01-22 |
| 145 | Continuous Glucose Monitors (CGMs) and Readmission Rates PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Among the diffident groups of patients, those with chronic and severe medical conditions are more likely to be readmitted to the hospital. It is not surprising therefore that patients with diabetes have high readmission rates. Patients with diabetes have 40% higher re-hospitalization rates compared with those patients without diabetes, with 30-day readmission rates reported to range between 14% and 26%. It should be noted that almost 30% of the patients with diabetes are experiencing two or more hospital admissions per year, … |
ILIAS SPANAKIS; | 2025-11-03 |
| 146 | Discovery Diabetes: A Pilot Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if the Discovery Program can help improve diabetes management in adolescents and young adults with type 1 diabetes (T1D). The main questions it aims to answer are: Does the Discovery Program lead to better glycemic control as measured by HbA1c levels? How does participation in the Discovery Program affect diabetes distress and self-management skills? Researchers will compare participants in the Discovery Program to those receiving standard diabetes care to see if the program has a positive effect on diabetes management. Participants will: Engage in a 3-month intervention that includes personalized mobile health communications and clinician support. Complete surveys and assessments at the beginning of the study, and again at 3 and 6 months. Allow the study team to access their electronic health records for additional data on diabetes management. |
SHELAGH MULVANEY; | 2025-12-23 |
| 147 | Contribution of A Combined T1D Autoantibody Test and Immunoreactive Trypsin Assay on Blotting Paper in The Detection of Type 1 Diabetes (Stage 3) in The Pediatric Population With A View to Its Subsequent Use in Early Detection (Stages 1 and 2) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: T1D is an autoimmune disease characterized by the presence of autoantibodies usually assayed separately on venous blood. The use of a combined test on capillary blood using a blotting paper would facilitate the immunological presymptomatic T1D screening in routine clinical practice as it is easy to perform and can be performed at home by families. However the use of a combined test on blotting paper must be validated before it is used in routine clinical practice for preclinical T1D screening purpose at large scale, starting with pediatric first degree relatives of T1D patients: this is the aim of this study, … |
KEVIN PERGE; | 2026-01-23 |
| 148 | Caracterización De Subgrupos De Personas Con Diabetes Tipo 1: Análisis De Características Clínicas Y Glucométricas Utilizando Una Aproximación De Inteligencia Artificial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to characterize different subgroups among patients with type 1 diabetes. The main research question is: Are there distinct subtypes among people with type 1 diabetes? Participants will be invited to take part in the study by allowing access to their health data. They will not be required to undergo any additional examinations, tests, visits, or interventions. |
ROSA M CORCOY; | 2026-03-10 |
| 149 | Community-Engaged Approach to Supporting South Asians With Type 2 Diabetes at Risk for Depression PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will adapt a community health worker (CHW)-led Type 2 diabetes (T2D) intervention to include mental health and digital components using a trauma informed care approach, and test the feasibility and acceptability of this intervention to support South Asians with T2D at risk for depression. |
NAHEED AHMED; | 2025-10-22 |
| 150 | A Multicenter, Double-blind, Active-controlled, Randomized, Parallel Clinical Trial to Evaluate The Efficacy and Safety of DA-2811 When Added to Ongoing BT-1 and BT-2 Combination Therapy in Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multicenter, double-blind, active-controlled, randomized, parallel clinical trial to evaluate the efficacy and safety of DA-2811 when added to ongoing BT-1 and BT-2 combination therapy in patients with type 2 diabetes who have inadequate glycemic control |
DONG A ST | 2025-11-20 |
| 151 | Use of Continuous Glucose Monitoring in Veterans With Uncontrolled Diabetes Managed Without Insulin Therapy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The U.S. Food and Drug Administration (FDA) has approved multiple Continuous Glucose Monitoring (CGM) devices from different manufacturers to be used as an aide in patients with type 1 and type 2 diabetes who require medications, and more recently, as over the counter versions for patients with and or without diabetes who want to better understand how diet and exercise may impact blood sugar levels. However robust evidence supporting that CGM is significantly superior to traditional home fingerstick blood glucose monitoring (FSBGM) in this population is lacking. Thus, … |
CARLOS MENDEZ; | 2025-08-18 |
| 152 | A Phase IV Clinical Trial to Evaluate The Efficacy and Safety of DA-5218 in Patients With Type 2 Diabetes Inadequately Controlled With Metformin PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multicenter, double-blind, active-controlled, randomized, parallel, phase IV clinical trial to evaluate the efficacy and safety of DA-5218 in patients with type 2 diabetes who have inadequate glycemic control with metformin |
DONG A ST | 2025-11-17 |
| 153 | Effects of Intraoperative Near-Infrared Spectroscopy and Postoperative Recovery on Glycemic Control Levels in Patients With Diabetes Mellitus: A Prospective Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective observational study aims to evaluate the effect of glycemic control level on intraoperative cerebral oxygenation measured by near-infrared spectroscopy (NIRS) and postoperative recovery in patients with diabetes mellitus undergoing elective urologic surgery under general anesthesia. Patients will be grouped according to HbA1c levels to assess the relationship between long-term glycemic control and intraoperative regional cerebral oxygen saturation, hemodynamic parameters, and postoperative recovery scores. |
NURSEN KARACA; | 2026-03-24 |
| 154 | The Effect of Individualized Nursing Interventions for Blood Glucose Variability Risk on Nursing Outcomes and Self-Management of Diabetes in Patients With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Type 2 diabetes is a chronic disease with an increasing prevalence worldwide and in our country. In managing type 2 diabetes, the primary goal in the nursing process is to ensure blood glucose stability. In this regard, it is essential to provide individualized nursing interventions and diabetes management education to individuals. The Comprehensive Self-Management of Diabetes Scale can be used to determine individuals’ level of diabetes management. Implementing systematic nursing interventions to maintain blood glucose stability and evaluating their impact on nursing outcomes and diabetes management are crucial. Although the NANDA, NIC, … |
EMEL BAYRAKTAR; | 2025-09-30 |
| 155 | The Effect of WhatsApp-Based and Family-Involved Self-Management Education and Support on HbA1c, Family Support, and Self-Management in Individuals With Type 2 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the effects of a WhatsApp-based and family-involved self-management education program on self-management, family support, and HbA1c levels among individuals with type 2 diabetes mellitus (T2DM). Hypotheses: * H1: There will be a significant difference in self-management scores between the intervention group receiving the WhatsApp-based and family-involved self-management education and the control group. * H2: There will be a significant difference in HbA1c levels between the intervention group receiving the WhatsApp-based and family-involved self-management education and the control group. * H3: There will be a significant difference in family support scores between the intervention group receiving the WhatsApp-based and family-involved self-management education and the control group. This randomized controlled trial will be conducted with 44 individuals diagnosed with T2DM who meet the inclusion criteria and one family member per participant (total 88 participants). Eligible patients will be randomly assigned to either the intervention or control group using a computer-generated randomization list. Participants (people with diabetes and their family members) in the intervention group will receive a 12-week, WhatsApp-based self-management education program. Educational modules (videos, visuals, and written materials) will be shared separately with each person with diabetes and their participating family member via WhatsApp twice a week. To reinforce learning, a five-question quiz will be sent separately to both the person with diabetes and the family member every Thursday. In addition, a brief follow-up phone call (approximately 10 minutes) will be conducted once a week only with the person with diabetes to review progress and provide feedback. Data collection will occur at baseline and at the end of the 12th week. Participants in the control group will continue their routine outpatient follow-ups for three months and complete the same measurement tools at baseline and post-intervention. Data will be collected using the Diabetic Participant Demographic Form, Family Member Demographic Form, Diabetes Self Management Questionnaire, Hensarling’s Diabetes Family Support Scale, and the Diabetes Knowledge Scale for Adults. Statistical analyses will be performed using SPSS software. Group comparisons will be analyzed with independent t-tests or Mann-Whitney U tests, and pre-post comparisons with paired t-tests or Wilcoxon tests. A significance level of p\<0.05 will be used. |
ALEYNA ÖZKAN; | 2025-11-21 |
| 156 | Cohort Studies on Metabolic Syndrome and Prediabetes PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to establish a cohort of individuals with metabolic syndrome and prediabetes to enable long-term follow-up of risk factors, disease progression, and the development of obesity-related complications. The study will also monitor changes in nutritional status and physical function over time, in order to identify key prognostic determinants influencing clinical outcomes. Metabolic syndrome and prediabetes are chronic multisystem disorders, and poor long-term control is closely associated with the development of various complications. Moreover, malnutrition and functional decline are common comorbid conditions that further impair quality of life and impose a substantial burden on healthcare resources. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2025-11-24 |
| 157 | TEPLIzumab: QUality of Life Evaluation During Stage Transition PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study is an observational, longitudinal, non-interventional real-world study in the United States. The study is meant to describe the experience of participants with a history of stage 2 type 1 diabetes who have been infused with teplizumab and the experience of participants with stage 2 type 1 diabetes who have not been infused with teplizumab, and to compare descriptively the experiences of the two groups. Primary Objective: \- To characterize health related quality of life, diabetes-related anxiety, diabetes-related burden, and ease of diabetes management, and how participants feel, … |
SANOFI | 2025-12-03 |
| 158 | The Influence of GLP1-RA on Periodontal Health – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Periodontitis is among the most common chronic diseases worldwide and, along with caries, represents the leading cause of tooth loss. More recent theories regarding the etiology of periodontitis also attribute a significant role to the body’s inflammatory response in the development and progression of the disease. It is already well established that periodontitis is bidirectionally associated with other systemic inflammatory conditions, such as type 2 diabetes mellitus. Results from meta-analyses suggest that diabetes increases the likelihood of periodontal disease by approximately 24%, while periodontitis, conversely, … |
MEDICAL UNIVERSITY OF GRAZ | 2025-09-24 |
| 159 | Establishment of Hong Kong Diabesity Register and A 3-year Randomized Clinical Trial for The Investigation of The Effectiveness of A Multicomponent Integrated Care Program in Chinese With Diabesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: People with diabetes and obesity (diabesity) are difficult to treat with many unmet needs requiring personalized treatment regimens, intensive counselling and emotional support. Here, we propose to conduct a pragmatic trial including 2 parts: (1) establishment of a register for Hong Kong Chinese with diabesity and through this register, identify participants consecutively to enter (2) a 3-year randomized clinical trial to assess the effects of multicomponent integrated care program supported by a team of endocrinologist, dietitian, psychologist and research assistant with elements including medical therapy, cognitive behavioural therapy, e-care, artificial intelligence chatbot, biofeedback, … |
ALICE PIK SHAN KONG; | 2026-03-03 |
| 160 | Growth Hormone Resistance of Beta-cells in Women With Gestational Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes. |
BETTINA MITTENDORFER; | 2025-11-14 |
| 161 | The Effect of Golden Rice Cookies With Piper Crocatum Extract on Lipid Profile Control in Patients With Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: People with diabetes often experience abnormal blood fat levels, known as dyslipidemia, which increase the risk of heart disease and stroke. The aim of the study, researchers are exploring a natural and practical solution through a healthy snack in the form of cookies. These cookies are made from Golden Rice, which is rich in beta-carotene as a natural antioxidant, and Piper crocatum (red betel leaf) extract, which contains polyphenols and flavonoids that may help lower cholesterol, reduce inflammation, and protect blood vessels. In this study, patients with diabetes will consume the cookies for 28 days, … |
ALTJE SUWARDI ABRAM; | 2025-12-08 |
| 162 | A Phase IIIb Clinical Study to Assess The Efficacy and Safety of GZR4 in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will be conducted to compare the efficacy, safety and patient-reported outcome of GZR4 and Insulin Icodec with or without Non-Insulin Antidiabetic Agents in subjects with Type 2 Diabetes Mellitus (T2DM) treated with basal insulin. |
GAN & LEE PHARMACEUTICALS | 2025-11-25 |
| 163 | A Phase 2, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Reduction With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight and With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks. |
SUNILDAT MAHESHWARI; | 2026-03-02 |
| 164 | STrong Relationships to Improve DiabEtes (STRIDE) Pilot PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a pilot and feasibility study for a mobile phone-delivered intervention, called STRIDE (STrong Relationships to Improve DiabEtes), designed to provide support for adults with type 2 diabetes (improve glycemic management and social support). The goal of the study is to examine the feasibility and acceptability of STRIDE. |
MCKENZIE RODDY; | 2025-10-20 |
| 165 | The Effect of WhatsApp-Supported Education and Counseling on Healthy Lifestyle Behaviors, Glycemic Control, and Knowledge Levels in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is one of the leading causes of death and disability worldwide, with type 2 diabetes mellitus (T2DM) being a major risk factor that doubles the risk of ischemic stroke. Glycemic dysregulation is observed in nearly two-thirds of patients after acute stroke and is associated with both the severity of the initial cerebrovascular event and the risk of recurrence. Effective glycemic control, patient education, and adherence to treatment are therefore critical for secondary stroke prevention and improved patient outcomes. Mobile health technologies, particularly social media applications, … |
NILGÜN ARAS; | 2025-10-06 |
| 166 | Randomized, Open Label Study to Examine The Outcomes of Physiologic Insulin Resensitization in Patients With Chronic Kidney Disease and Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research is to evaluate outcomes of physiologic insulin re-sensitization (PIR) in patients with Chronic Kidney Disease (CKD) and Type 2 Diabetes Mellitus (T2DM). |
SUNGCHUN LEE; | 2025-10-20 |
| 167 | A Phase 2, Randomized, Open-Label, Comparator-Controlled Trial to Evaluate The Efficacy and Safety of LY3938577 in Study Participants, With Type 2 Diabetes Previously Treated With Basal Insulin PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to see how well LY3938577 works and how safe it is compared to degludec in people with type 2 diabetes. Participation in the study will last about 26 weeks. |
GIRISH KARAMCHANDANI; | 2026-03-02 |
| 168 | Cohort Study of Patients With Type 2 Diabetes PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes mellitus |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2026-03-30 |
| 169 | Digital Therapy for Individualized Intervention and Management of Gestational Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Existing studies have shown that the management combined with digital health technology can increase the qualified rate of blood glucose in pregnant women with gestational diabetes mellitus (GDM), and the earlier the intervention, the better the effect of blood glucose control. Previously, there was a lack of relevant research on digital therapeutics for the systematic management of gestational diabetes in China. A data-driven digital therapy product for gestational diabetes (doctor’s end + patient’s end) was established. This product integrates functions such as information recording, risk assessment, evaluation and suggestion, prescription issuance, … |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2025-09-15 |
| 170 | The Impact of Need-driven Treatment of Insulin-Deficient Diabetes on The Care Events, Glycemic Control, Risk Factors, and Complications in The Pirkanmaa Wellbeing Services County, Finland PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective study evaluates the safety of extending the interval of routine calendar-based follow-up visits from every 12 months to every 24 months in patients with type 1 diabetes who are in good glycemic control and suitable for remote monitoring. The primary outcome is the proportion of patients who maintain good glycemic control during the 24-month follow-up period. Participants will attend two in-person visits at baseline (month 0) and at the end of follow-up (month 24), which include a comprehensive clinical examination, assessment of glucose control, … |
SAARA METSO; | 2025-08-19 |
| 171 | The Digital Diabetes Patient Reminder (DIPAR) Tool to Improve Clinical Outcomes and Process of Management in Adults With Type 2 Diabetes: A Proof-of-Concept Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Digital health tools may present an opportunity to address these challenges by enhancing care delivery, improving patient engagement, and facilitating better disease management for chronic diseases such as type 2 diabetes mellitus (T2DM). This primary objective of this randomized controlled trial is to evaluate whether the Diabetes Digital Patient Reminder (DIPAR), embedded in patient portal, can increase the proportion of T2DM patients who have their albuminuria measured at least once annually by either a general practitioner (GP) or a diabetes specialist, as documented in their hospital medical records (EMD), thereby reflecting active monitoring of diabetes-related parameters. |
GODERIS GEERT; | 2026-02-19 |
| 172 | The Validity of A Continuous Glucose Monitor in Diagnosing Gestational Diabetes: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective pilot study to assess the validity of using a continuous glucose monitor (CGM) in diagnosing gestational diabetes mellitus (GDM). Pregnant individuals between the ages of 18-50 years old receiving prenatal care at Mount Sinai Hospital (e..g, E-Level clinic and Faculty Practice Associates) will be enrolled. Potential participants will be approached during their prenatal care appointments. Participants will complete an informed consent form for the study during their standard-of-care prenatal appointments at our institution. |
ANGELA BIANCO; | 2026-01-15 |
| 173 | CAPAZ-2D: Continuous Glucose Monitoring to Augment and Personalize Self-Management of Type 2 Diabetes in Hispanic/Latinx Young Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Type 2 diabetes in increasing common in young adults. Utilizing a mixed-methods, community-based approach, this study offers continuous glucose monitors (CGMs) to young adults with type 2 diabetes for 30 days, and collects both quantitative and qualitative data to understand barriers and facilitators of CGM use, participants’ changes in awareness of glucose patterns while using the CGM, and preferences for a CGM-based self-management intervention. |
JESSICA L MCCURLEY; | 2026-01-08 |
| 174 | Effectiveness of A Culturally Tailored Medical Nutrition Therapy for African Patients With Type 2 Diabetes: The Objectif Santé Diabète Benin (OSanDiaBé) Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The clinical trial aims to assess the effectiveness of the Objectif Santé Diabète Benin (OSanDiaBé), a culturally tailored medical nutrition therapy (MNT), in enhancing diabetes management and nutrition choices. It seeks to answer two main questions: 1. Does the culturally tailored MNT lower HbA1c levels at 12 months compared to usual care? 2. Does it improve dietary behaviors at 12 months compared to usual care? |
HALIMATOU ALAOFE; | 2025-08-28 |
| 175 | Patient and Family Health Literacy – A Survey Among 5000 People PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to identify health literacy strengths and needs among people living with type 2 diabetes and multi-disease and their family members. |
UNIVERSITY OF SOUTHERN DENMARK | 2025-09-26 |
| 176 | Study on The Applicability of New Technologies for Diabetes Complication Management Based on Mobile Health and Wearable Devices PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The value of intelligent lifestyle intervention for T2D and its complications has been initially explored, but evidence-based support for the effectiveness of related AI risk prediction models and intervention models remains to be confirmed. The primary objective of this study is to verify the effectiveness of an AI model for predicting the risk of T2D complications based on phenotype, laboratory indicators and wearable device indicators, and to explore the effect and applicability of an intelligent lifestyle intervention model combining wearable devices and smartphones in preventing T2D complications. |
SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2025-08-19 |
| 177 | A Multicenter, Randomized, Open-Label, Parallel-Controlled Clinical Study Comparing The Efficacy and Safety of Cofrogliptin Versus Acarbose in Drug-Naïve Patients With Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will compare the effect and safety of cofrogliptin (HSK7653) with acarbose among people with type 2 diabetes |
HAISCO PHARMACEUTICAL GROUP | 2025-09-26 |
| 178 | Assessment of Diabetes Distress and Quality of Life in Sohag University Students With Type 1 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to encourage and support Sohag University Students with type 1 Diabetes Mellitus (T1DM). It will discover students with poor glycemic control, diabetic retinopathy, and renal complications. In addition to focus on those students suffering from Diabetes Distress (DD) and poor Quality of Life (QOL) due to type 1 Diabetes Mellitus (T1DM). |
DINA ABDELNABY AHMED; | 2025-08-08 |
| 179 | Menstrual Cycle Changes in Adolescent Girls With Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To assess menstraul cycle changes in adolescent girls with diabetes and to find out the various risk factors |
ZEINAB MEGAHED MOHAMMED SHELGAMY; | 2025-09-26 |
| 180 | Role of Omega-3 Fatty Acids in Modulating Retinal Microvascular Changes in Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this clinical trial is to learn if omega-3 fatty acid supplements help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. It will also learn about the safety of omega-3 supplements. The main questions it aims to answer are: Do omega-3 supplements improve the health of retinal blood vessels in adults with type 1 diabetes? Are there any side effects when taking omega-3 supplements? Researchers will compare participants taking omega-3 supplements to a control group (if applicable) to see if the supplements help support retinal blood vessel health. Participants will: Take a daily omega-3 supplement for the duration of the study Attend regular eye exams to monitor changes in the retina Report any side effects or health changes during the study |
NIDA AMIN; | 2025-12-01 |
| 181 | THE EFFECT OF HEALTH PROMOTION MODEL-BASED EDUCATION AND MOTIVATIONAL INTERVIEWS GIVEN TO PARENTS OF CHILDREN DIAGNOSED WITH TYPE 1 DIABETES ON DIABETES SELF-MANAGEMENT AND QUALITY OF LIFE PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This quasi-experimental study will aim to evaluate the effects of Health Promotion Model-based education and motivational interviewing on diabetes self-management and quality of life among parents of children diagnosed with type 1 diabetes. Eligible and voluntary parents will receive structured education sessions and motivational interviews designed to support diabetes management and improve quality of life. Outcomes will be assessed using validated questionnaires on diabetes self-management and quality of life, as well as HbA1c values obtained from patients’ routine medical records. The study will examine whether parent-focused interventions can enhance diabetes management in children and families. |
GÖZDE EKŞİ; | 2025-10-08 |
| 182 | Injection Ports Versus Single-Use Needles for Insulin Administration in Diabetic Pregnancies: Impact on Dose Adherence and Patient Satisfaction PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study wants to find out if using an injection port to give insulin during pregnancy helps people take their insulin more regularly and feel better about their care. When someone has diabetes during pregnancy, … |
LORIE HARPER; | 2025-09-10 |
| 183 | Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH) PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: Sixteen institutions will be selected from a HRSA uniform data system and have data collected for up to 3 years. Eight institutions will begin the iPATH practice transformation during year one, the other eight institutions will begin iPATH in year two. FQHC administrators, clinicians and staff will be enrolled to participate in the iPATH transformation in their clinic and will participate in qualitative interviews. Patient HbA1c data from the clinics will be collected for comparative data analysis during each year of the study. |
SARA SINGER; | 2025-12-17 |
| 184 | Effects of RO7204239 on Insulin Sensitivity, Muscle Composition and Function in Participants Living With Type 2 Diabetes Mellitus and Overweight or Obesity: A Double-blind, Randomized, Placebo-controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of this study is to assess the effect of RO7204239 on insulin sensitivity versus placebo in participants with T2DM and obesity or overweight. |
HOFFMANN LA ROCHE | 2026-03-12 |
| 185 | Effect of Baduanjin Exercise on Health and Wellbeing for Health Sustainability in Diabetic Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is conducted to assess baduanjin exercise for its ability to reduce cortisol levels in type 2 diabetic patients which in turn contributes to lowering blood glucose levels. the potential improvement in blood sugar levels can positively affect patients’ quality of life and improving activities of daily living by reducing complications and dependance on medications , so baduanjin exercise supports the concept of health sustainability and enhancing long term wellbeing. |
HEBATULLAH HAMDY MAHMOUD; | 2026-03-18 |
| 186 | Using Data to Transform Diabetes Care and Patient Lives: Substudy 1: Hong Kong Gestational Diabetes Register (HKGDR) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Gestational diabetes mellitus (GDM) is a common condition that affects approximately one out of every six pregnancies. It is defined by elevated levels of blood glucose during pregnancy, usually detected through a glucose challenge test conducted at approximately 24-28 weeks of gestation. Gestational diabetes, by nature of the elevated glucose levels during pregnancy, is known to be linked to an increased risk of some conditions in the mother. Furthermore, the elevated glucose, if not well controlled, can be linked to a higher birth weight in the baby, … |
RONALD C.W. MA; | 2025-12-23 |
| 187 | Comparative Effects of High-Intensity Interval Training in Pre and Postmenopausal Women With Type II Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes Mellitus (DM), a chronic metabolic disease-causing chronic hyperglycemia. Globally more than 90% cases are of type II diabetes mellitus (T2DM). Around 537 million adults worldwide had diabetes but according to data from Pakistan, female sufferers are marginally higher (26.4%) as compared to men (25.1%). The main causes of DM II are genetic predispositions, including consanguinity, dietary changes, urbanization and sedentary lifestyles. It is reported that postmenopausal status is linked to worsened glycemic control, increased visceral adiposity and and inflammation, … |
HUMA RIAZ; | 2026-04-03 |
| 188 | Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT) PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials. The investigators’ goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies. |
SHIRLEY VICHY WANG; | 2025-10-31 |
| 189 | Studying The Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This multicenter cross-sectional study will include a diverse population of adolescents and adults with CF. The overall Aim is to describe prevalence of diabetes microvascular complications and macrovascular surrogates in people with established CFRD. |
JAEB CENTER FOR HEALTH RESEARCH | 2026-02-10 |
| 190 | Effectiveness of Virtual Health Coaching Based on Artificial Intelligence to Improve Glycemic Control in Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effectiveness of a virtual health coaching program based on artificial intelligence (AI) in improving blood sugar control among people with type 2 diabetes in primary health care settings in Jeneponto and Bantaeng, Indonesia. The intervention will be delivered through the DIACOACH application, which provides personalized coaching, lifestyle guidance, and self-care support. Participants will be randomly assigned to either the intervention group, receiving virtual health coaching for 12 weeks, or the control group, receiving standard diabetes education. Main outcomes include fasting blood sugar and HbA1c levels. Other outcomes include self-care adherence, dietary behavior, … |
ANDINA SETYAWATI; | 2025-09-10 |
| 191 | Integrating Diabetes Care Into Primary Healthcare Centers in Abuja, Nigeria: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study, Integrating diabetes care into Primary Healthcare Centers (PHCs) in Abuja, Nigeria: a pilot study, is to screen, diagnose, treat, and educate diabetes patients in two selected PHCs in Abuja. This single-arm pilot trial will test the feasibility of integrated diabetes care, measure the implementation outcomes, and explore the effectiveness of the strategy bundle using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. |
IKECHUKWU ANTHONY ORJI; | 2026-03-27 |
| 192 | Effect of Culturally Tailored Diabetes Education on Self-Management Behaviors of Adult Hispanic Males With Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes mellitus (DM) is a global public health concern. In the United States, adult Hispanic males are particularly vulnerable to type 2 diabetes mellitus and are more likely to develop complications and subsequently die from it, compared to non-Hispanic White males. Evidence suggests good self-management behaviors can potentially prevent disease-related complications and improve clinical outcomes. The American Diabetes Association and Association of Diabetes Care and Education Specialists have endorsed diabetes self-management education as a necessary component of care for all individuals living with the disease. However, … |
BERYL O’DONNELL; | 2026-02-12 |
| 193 | Impact of Glycemic Variability on Diabetes Self-care, Glycated Hemoglobin, Diabetes Distress, Fatigue, and Quality of Life in People With A Dual Diagnosis of Gastrointestinal Cancer and Diabetes After Surgery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In study phase 1, the investigators will prospectively examine the factors related to post-operative glycemic variability and its effect on outcomes in people with both DM and GI cancer after surgery. The study will also qualitatively understand the glycemic variability experiences and their associated symptoms and outcomes in people with both DM and GI cancer. In study phase 2, the investigators will develop and test the effects of the CGM-Assisted Reflection Education (CARE) program on adults with both DM and GI cancer post-surgery. |
HSUAN-JU KUO; | 2025-09-18 |
| 194 | An Active Health-Based Comprehensive Study on Diabetes Management PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized, open-label, multicenter trial evaluates the efficacy and safety of the AI-based lifestyle guidance system (X-Life) compared to standard care in adults with type 2 diabetes. X-Life integrates glucose level, wearable devices, and AI-driven decision models to provide personalized lifestyle recommendations. The primary endpoint is the percentage of time in glucose target range (TIR). |
LI HUATING; | 2026-02-12 |
| 195 | Feasibility of Use of Fitbit, Brief DSMES, and Targeted Text Messaging in Sedentary Adults With Type 2 Diabetes in Primary Care Settings PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to evaluate the feasibility and acceptability of a 12-week intervention utilizing a Fitbit and artificial intelligence (AI)-delivered diabetes self-management education and support (DSMES) with tailored text messages. The main question it aims to answer is: Does providing a wearable fitness and activity tracker plus AI-tailored and DSMES improve clinical outcomes for patients with type 2 diabetes? Participants will complete a baseline visit, wear a Fitbit and answer text messages for 12-weeks, and complete by a final visit. |
SETH KRAMER; | 2025-11-13 |
| 196 | Development of Artificial Intelligence Tools for The Detection of Stress Markers and Consideration of Stress States in The Monitoring of Subjects With Type 1 Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stress refers to all the reactions of an organism subjected to exogenous or endogenous stress. In the context of diabetes, stress plays a critical role. There are two forms of stress: acute and chronic, both of which can have a significant impact on patients’ glycaemic control. Acute stress, if repeated, can cause rapid increases in blood glucose levels, while chronic stress can lead to insulin resistance. It is therefore essential to develop tools for recognising and quantifying stress states specific to patients with diabetes. These tools would provide a better understanding of the role of stress in diabetes management, … |
PIERRE-YVES BENHAMOU; | 2026-02-18 |
| 197 | Voice Biomarkers for Type 2 Diabetes Detection: A Two-Stage Validation Study PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn if computer analysis of voice recordings can detect Type 2 diabetes in adults. The main questions it aims to answer are: * Can advanced voice analysis accurately identify participants with Type 2 diabetes or pre-diabetes based on vocal biomarkers? * How do voice-based predictions compare to HbA1c blood test results for diabetes screening? * Can machine learning approaches effectively address the challenge of undiagnosed diabetes in population screening? Participants will: * Record themselves reading a short passage and answering brief questions out loud in a single online session. * Complete health questionnaires about diabetes risk factors, medications, and general health status. * A subset of participants (n=1,000) will provide a blood sample through an at-home HbA1c testing kit to validate voice-based predictions against laboratory results. * Use their own devices (computer, tablet, or smartphone) to complete all study activities online from home. |
THYMIA | 2026-03-19 |
| 198 | Study to Explore The Prevalence of Hypercortisolism in Patients With Type 2 Diabetes and Assess The Correlation Between Salivary Cortisol and Glucose Levels PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to explore the prevalence of hypercortisolism in a population with difficult to control type 2 diabetes despite receiving standard-of-care therapies. Additionally, the study will evaluate the correlation between salivary cortisol levels and glycemic control. |
JIAN ZHOU; | 2025-09-05 |
| 199 | Surveying Experiences and Lifestyle Effects in Choosing Technology and Hybrid Closed Loop in Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Type 1 diabetes requires a lot of work to try to keep glucose levels in the target range. Hybrid closed- loop, also known as artificial pancreas, takes glucose readings from a sensor (continuous glucose monitor) and uses an algorithm to tell an insulin pump how much insulin to deliver. Hybrid closed-loop has currently been rolled out to many people with type 1 diabetes in England. We are keen to develop a deeper understanding of the perspective of people living with type 1 diabetes who have choices about which hybrid closed-loop systems fit their needs. The main purpose of this study is to explore the choices and experiences of people living with type 1 diabetes regarding closed-loop therapy. |
UNIVERSITY OF NOTTINGHAM | 2025-09-24 |
| 200 | Effects of Rhythm-Based Music on Anxiety, Glucose, and Cortisol in Pregnancies With Gestational Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is for people who have gestational diabetes, a type of diabetes that happens during pregnancy. People with gestational diabetes may feel more anxious than others during pregnancy. This anxiety can affect their health and their baby’s health. The goal of this study is to see if rhythm-based music can help lower anxiety and improve blood sugar and stress hormone levels. Music may be a safe and low-cost way to support emotional and physical health during pregnancy. Researchers will test two types of music activities: Listening to rhythm-based music Doing rhythm-based music and breathing exercises The study will include 180 pregnant participants. They will be randomly placed into one of three groups. Each group will be at a different hospital to prevent crossover. Two groups will receive music activities, and the third group will receive usual care. Participants will stay in the hospital for 3 days. During that time: Anxiety will be measured on day 1 and day 3 using a short questionnaire Blood sugar will be measured 3 times a day (morning, afternoon, evening) Saliva samples will be collected on day 3 to measure cortisol (a stress hormone) Researchers will also record any medications used by participants. This study may show that music helps lower anxiety and improve health for people with gestational diabetes. It may also support the use of music as a helpful, non-drug option during pregnancy. |
ESIN CEBER TURFAN; | 2025-05-22 |