Clinical Digest: Recent Clinical Trials on Epilepsy (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Epilepsy. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Epilepsy (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Added Value of MRI Volumetry and Diffusion Tensor Imaging Over Conventional MRI in Temporal Lobe Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This works aims at evaluating the diagnostic performance of combined MRI Volumetry, Diffusion tensor imaging and Conventional MRI in lateralizing the epileptogenic focus in patients with temporal lobe epilepsy and correlate these findings with clinical outcome. |
REEM MOHAMED SAAD EL SHAZLY; | 2026-02-03 |
| 2 | A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Dravet Syndrome (DS) is a severe neurodevelopmental disease, which is predominantly caused by mutations of SCN1A, the gene coding for Nav1.1 voltage-gated sodium channels. DS is characterized by infancy onset, severe cognitive deficit and drug-resistant seizures, including several generalized convulsive seizures per day and frequent status epilepticus, often triggered by fever or hyperthermia. Among the causes of premature deaths in patients with epilepsy, sudden and unexpected death in epilepsy (SUDEP) represents a major cause. SUDEP is a non-traumatic and non-drowning death in patients with epilepsy, … |
HOSPICES CIVILS DE LYON | 2026-02-27 |
| 3 | Non-progressive Congenital Ataxia – Advancing Diagnosis to Enhance Chances for Targeted Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This multinational European observational clinical study focuses on non-progressive congenital ataxia (NPCA), a very rare early-onset neurological condition also within the cerebral palsy (CP) concept as ataxic CP. The study aims to improve the diagnosis and care of affected children through a comprehensive approach that integrates detailed clinical assessments, brain imaging analyses, and advanced genetic testing. By identifying developmental trajectories, specific impairment profiles, brain MRI patterns, and genetic variants, the researchers aim to elucidate underlying mechanisms, … |
KATE HIMMELMANN; | 2026-02-19 |
| 4 | Effect of Epilepsy and Antiepileptic Drug Therapy on Gastric Motility and Emptying By Comparing Gastric Volume With Point-Of-Care Gastric Ultrasound in Epileptic Patients After Standard CAS/ASA Fasting Guidelines PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: People with epilepsy often need surgery, but it is not fully known whether their stomachs empty food and liquids at the same rate as people without epilepsy. Some seizure medications, special diets, and nerve changes related to epilepsy may slow digestion, which could increase the risk of stomach contents entering the lungs during anesthesia. The purpose of this study is to find out whether people with epilepsy still have food or liquid in their stomachs before surgery, even after following standard fasting rules. To do this, … |
SUJOY BANIK; | 2026-02-19 |
| 5 | Epileptiform Potential of Fully Immersive Virtual Reality PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this interventional study is to determine if the use of virtual reality headsets results in an increased risk of seizure in adolescent and adult individuals with epilepsy. The main question it aims to answer are: \- does use of virtual reality headsets with hand controllers result in a higher risk of seizure compared to use of virtual reality headsets without hand controllers Participants will be asked to wear a virtual reality headset during continuous video EEG recording and EEG with be evaluated during three phases: with display turned off, with display turned on without hand controllers, … |
JARED E QUAST; | 2026-03-05 |
| 6 | Acute Stimulation for The Modulation of Epileptic Events With A Closed-Loop Brain Interchange System in Drug Resistant Epilepsy Related Papers Related Patents Related Grants Related Experts Highlight: Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange – BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, … |
NURI F. INCE; | 2026-03-23 |
| 7 | B6 Administration for Levetiracetam-Associated Neurobehavioral Changes and Epilepsy (BALANCE) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a supportive care study to assess the effect of Vitamin B6 supplementation on mood-related side effects of levetiracetam in patients with brain tumors, who have already been prescribed levetiracetam for the prevention of seizures. This study will assess this effect from the perspective of both the patient and the patient’s caregiver. Patients will receive Vitamin B6 as a supplement to take daily for 8 to 12 weeks, in addition to the already prescribed levetiracetam and will undergo study assessments as well as complete self-reported questionnaires to evaluate their mood during the course of the study. Additionally, … |
KATHERINE PETERS; | 2026-02-20 |
| 8 | Optical Imaging As A Diagnostic Tool for Monitoring Brain Function in X-linked Rare Disorders PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Fragile X syndrome (FXS, OMIM #300624) and Creatine Transporter Deficiency (CTD, #300352) are the two most common causes of X-linked intellectual disability. FXS and CTD affect hemizygous males and with highly variable severity heterozygous females. Both these neurodevelopmental disorders (NDDs) have a dramatic impact on the family quality of life and the health-care system. These disorders share common clinical traits, including intellectual disability, autistic-like features, behavioural and mood alterations and seizures. Brain anatomy appears largely normal, suggesting that functional deficits result from subtle changes in synaptic connectivity. Moreover, … |
AURORE CURIE; | 2026-04-01 |
| 9 | PNOC042: A Phase 2, Multi-institutional Trial, Evaluating The Efficacy of Laser Interstitial Thermal Therapy (LITT) in Children, Adolescents and Young Adults With Recurrent or Progressive Low-grade Gliomas (LGG) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the efficacy of Laser Interstitial Thermal Therapy (LITT) in treating recurrent or progressive, low-grade gliomas (LGG) in pediatric, adolescent and young adult patients. |
SABINE MUELLER; | 2026-04-01 |
| 10 | Validity and Reliability of An Immersive Virtual Reality Adaptation of The Timed Up and Go Test in Individuals With Chronic Non-Specific Low Back Pain PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates whether an immersive virtual reality (VR) version of the Timed Up and Go (TUG) test can accurately measure functional mobility in adults with chronic non-specific low back pain. The standard TUG test measures the time needed to stand up from a chair, walk 3 meters, turn around, walk back, and sit down. In the VR version (VR-TUG), participants perform the same movements while wearing a VR headset that displays a virtual environment. We will examine: (1) whether VR-TUG results are similar to the standard TUG, (2) whether VR-TUG is reliable when repeated about one week later, … |
MEHMET AKIF GULER; | 2026-02-11 |
| 11 | Bridging The Gap: Educating Patients on Social Determinants of Health to Improve Epilepsy Surgery Access and Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to identify the needs and barriers to accessing and undergoing epilepsy surgery for patients with epilepsy and then to pilot an educational program regarding the social determinants of health and how they can influence surgical rates and epilepsy outcomes. For the first part, patients (age 18+) and providers will be asked to complete surveys and participate in focus groups to identify gaps and barriers that limit access to and use of epilepsy surgery. For piloting the education program, … |
ANNY REYES; | 2026-04-03 |
| 12 | Randomized, Double-Blind, Placebo-Controlled Cross-Over Study to Evaluate The Effects of Cannabidiol on Neurobehavioral and Function Outcomes in Sanfilippo Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to test cannabidiol in Sanfilippo syndrome. The main questions it aims to answer are: 1) determine the safety of cannabidiol in Sanfilippo syndrome, and 2) explore the efficacy of cannabidiol in treating the neurobehavioral symptoms and functional outcomes of Sanfilippo syndrome. Each participant’s caregiver will be asked to complete surveys related to the participant’s behavior, mood, sleep, stooling, pain, and caregiver stress intermittently throughout the study. All participants will be enrolled into one of two cohorts based on enrollment order: 1. Sentinel Safety Cohort (first 5 participants) – … |
LYNDA E POLGREEN; | 2026-02-27 |
| 13 | Characterization of The Natural History of Microduplication Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: 7q11.23 duplication syndrome (7q duplication syndrome/7DUP) is caused by a microduplication of the 7q11.23 chromosomal region, encompassing 26-28 genes, including the GTF2I gene. This syndrome, often considered as a mirror phenotype of Williams-Beuren syndrome (WBS), is characterized by a wide range of neurodevelopmental impairments, including a neurodevelopmental disorder (NDD), autism spectrum disorders (ASD), selective mutism, mild dysmorphic features, and aortic dilation. Notably, one of the core clinical features of 7DUP is socialization impairment, which varies in severity across individuals. The GTF2I gene, identified as critical in the pathogenesis of both WBS and 7DUP, … |
HOSPICES CIVILS DE LYON | 2026-03-13 |
| 14 | Cognitive and Functional Telehealth-based Assessment and Intervention in Veterans With Psychogenic Nonepileptic Seizures PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Psychogenic nonepileptic seizures (PNES) reflect a subtype of functional neurological disorder (FND) that is common and extremely disabling in Veterans. Cognitive problems are highly prevalent in PNES, they reduce quality of life, and they severely limit daily functioning. Currently, there are no available treatments that target cognition to improve daily function in PNES or other FNDs, … |
RYAN A VAN PATTEN; | 2026-03-12 |
| 15 | Efficacy and Safety of Eptifibatide Therapy Following Intravenous Thrombolysis in Acute Ischemic Stroke Patients Within 4.5 to 24 Hours After Onset: A Multicenter, Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, open-label, blinded-endpoint clinical trial designed to evaluate the efficacy and safety of early administration of eptifibatide following intravenous thrombolysis in patients with acute ischemic stroke who present 4.5 to 24 hours after symptom onset. |
ZHONGMING QIU; | 2026-01-16 |
| 16 | Traumatic Brain Injury – Efficacy of Steroids in Acute Vasogenic Edema PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the impact of dexamethasone treatment in traumatic brain injury patients with vasogenic edema in the second week after the trauma, administered in centers where this intervention has been considered to treat brain edema. The main question it aims to answer is: Does dexamethasone in a regimen of 8mg/8h for 5 days improve vasogenic edema in patients after 5 days of their trauma? Participants already receiving this treatment as part of their regular medical care in emergency settings, general wards, or ICU settings for TBI will be included, … |
ANDRES M. RUBIANO; | 2026-01-22 |
| 17 | Targeted Hypothermia Versus Targeted Normothermia After Convulsive Refractory Status Epilepticus: A Multicenter Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The HYBERNATUS-II study is a phase-III, open-label, randomized controlled trial in patients with convulsive refractory SE receiving mechanical ventilation. Patients are allocated at random to either early targeted hypothermia for 24 hours or targeted normothermia at the acute phase of ICU management. This trial is a superiority multicentric trial and patients will be randomized in a 1:1 ratio using an electronic Cas Report Form. Before any examination or intervention related to the study may be carried out, the investigator must obtain the freely given, informed and written consent of the participant, or of his/her substitute decision maker (family member, … |
LEGRIEL STEPHANE; | 2026-02-10 |
| 18 | Dense Cranial Electroacupuncture Stimulation Plus Body Acupuncture for Adolescents With Psychological Distress: A Randomized Controlled Trial With Observations on Salivary Oxytocin and Cortisol Changes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is an assessor-blinded, randomized, MAS-controlled trial. A total of 148 adolescents aged 15-22 years experiencing mild to moderate anxiety or depressive symptoms will be recruited. They will be randomly assigned to DCEAS+BA (n = 74) and MAS (n = 74) for 2 sessions per week for 8 weeks, followed by a 4-week post-treatment observation period. A post-intervention visit will be held at week 12. The primary outcome will be assessed using the Chinese version of the Beck Anxiety Inventory (BAI-C). The secondary outcomes include the Beck Depression Inventory II (C-BDI-II) for depression, … |
ZHANG ZHANG-JIN; | 2026-01-26 |
| 19 | Pediatric Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the research is to better understand how the human brain accomplishes the basic cognitive tasks of learning new information, recalling stored information, making decisions or choices about presented information and self-control. These investigations are critical to better understand human cognition and to design treatments for disorders of learning, memory, decision making and cognitive control. |
ANGELA PRICE; | 2026-02-13 |
| 20 | Effect of Oral Melatonin Versus Oral Midazolam As A Premedication in Children Undergoing Tonsillectomy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal. Melatonin is a hormone secreted by the pineal gland. Melatonin is different from benzodiazepines and their derivatives in that it exerts a promoting effect on sleep by amplifying day/night differences in alertness and sleep quality and displaying a modest sleep-inducing effect, quite mild as compared to that seen with benzodiazepines (Ahmad et al., … |
WAEL SAYED EL GHARABAWY; | 2026-01-13 |
| 21 | A Longitudinal Natural History Study of Adults and Children With Angelman Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the natural progression of Angelman syndrome (AS) in children and adults with a confirmed genetic diagnosis of AS. The main questions it aims to answer are: * How do developmental skills, such as communication, motor abilities, and adaptive behaviors, … |
CHRISTOPHER KEARY; | 2026-03-25 |
| 22 | CEST-based Biomarkers to Delineate The Epileptogenic Zone PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Epilepsy is a common neurological disorder with an incidence of 1%. Although many anti-seizure medications are available, about 30% of patients are resistant to drug treatments. Epilepsy surgery is an effective treatment for some of these patients. It involves removing the brain region responsible for generating seizures, called the epileptogenic zone (EZ). A pre-surgical evaluation is performed to locate and delineate the region where seizures originate (the seizure onset zone \[SOZ\]) and to confirm that this zone is unique and accessible for surgery-that is, … |
FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD | 2026-01-05 |
| 23 | The Effect of Blood Flow Restriction Training Combined With Transcranial Magnetic Stimulation on Limb Function in Hemiplegic Patients After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial aims to evaluate whether combining blood flow restriction training (BFRT) with repetitive transcranial magnetic stimulation (rTMS) improves limb function in stroke patients with hemiplegia. A total of 69 participants will be randomly assigned to three groups: conventional rehabilitation alone (control group), conventional rehabilitation plus rTMS, or conventional rehabilitation plus BFRT combined with rTMS. The intervention period is 4 weeks, with assessments conducted at baseline and at the end of treatment. The primary outcome is the change in upper extremity Fugl-Meyer Assessment (FMA-UE) score, which measures motor function recovery. Secondary outcomes include Wolf Motor Function Test, … |
SHENAO DU; | 2026-03-06 |
| 24 | Biomarkers of Response to SEEG Thermocoagulation in Patients With Refractory Focal Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Drug-resistant focal epilepsy is a severe neurological disease that affects one-third of patients with epilepsy. Surgery is the only potentially curative treatment. Intracerebral exploration by stereo electroencephalography (SEEG) is an important step in the surgical pathway. It aims to establish the precise mapping of the epileptogenic network (EZN), including all the brain regions that generate seizures. At the end of SEEG, SEEG-guided radiofrequency thermocoagulation (SEEG RFTC) represents a therapeutic option that may be efficient as a palliative treatment in patients ineligible for resective surgery, or may lead, in some cases, to a definitive effect, … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2026-02-10 |
| 25 | Bimanual Training Versus Unilateral Task Specific Training in Children With Spastic Hemiplegic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebral palsy is one of the most common childhood neurological disorders and often results in weakness, poor coordination, and stiffness (spasticity) in one side of the body in children with spastic hemiplegic cerebral palsy. These difficulties can significantly affect a child’s ability to perform daily activities such as dressing, eating, playing, and school-related tasks. Upper limb rehabilitation plays a crucial role in improving independence and quality of life in these children. Two commonly used rehabilitation approaches are bimanual training, which focuses on using both hands together during functional tasks, and unilateral task-specific training, … |
MONTIHA AZEEM; | 2026-03-09 |
| 26 | The Impact of Health Literacy Education on Knowledge, Treatment Adherence and Stigma Among Adolescents With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Evaluating changes in knowledge, attitude, and practices (KAP) related to epilepsy and its treatment as a result of an educational intervention among adolescents with epilepsy to determine if improved KAP about epilepsy results in improved medication adherence and less perceived stigma. |
DEBORAH KOLTAI; | 2026-02-05 |
| 27 | A Prospective Cohort Study of High Intensity Focused Ultrasound Ablation for Brain Lesions in Children With Drug Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn if magnetic resonance imaging guided focused ultrasound (MRgFUS) can treat brain lesions causing epilepsy in children with drug resistant epilepsy. The main questions it aims to answer are: Is MRgFUS safe in children with drug-resistant epilepsy due to central brain lesions? Does MRgFUS treatment reduce seizure frequency and severity and improve quality-of-life? Researchers will prospective assess outcomes following MRgFUS in children. Participants undergoing MRgFUS will complete seizure diaries and questionnaires related to seizure severity and quality-of-life. |
GEORGE IBRAHIM; | 2026-03-27 |
| 28 | Evaluation of The FYNA Research OPM MEG Device for Locating Epileptic Foci As Part of Pre-surgical Assessment of Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The success of epilepsy surgery depends largely on the reliability of the preoperative localization of the epileptogenic zone. The conventional method for determining the area to be removed is based on a complex assessment involving an electroencephalogram (EEG) coupled with simultaneous video recording of seizures (video SEEG), a brain MRI, and a fluorodeoxyglucose positron emission tomography scan (PET-FDG). At present, epilepsy surgery cannot cure all patients. Since the prognosis for surgery depends primarily on the ability to delineate the epileptogenic zone, … |
JULIEN JUNG; | 2025-12-16 |
| 29 | Randomized Double-blind Placebo-controlled Study of The Evaluation of The Efficacy of Neurofeedback Technique Based on EEG Desynchronization in Pharmaco-resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A large proportion of patients (approximately 30%) with drug-resistant epilepsy are not eligible for surgical treatment. The alternatives that can be offered to reduce the frequency of seizures are neuromodulation (vagus nerve stimulation (VNS), deep brain stimulation (DBS), or transcranial direct current stimulation (tDCS)). Most of these alternatives require invasive procedures and therefore carry risks. Neurofeedback (NFB) is a potential adjunctive treatment that allows patients to self-modulate brain activity and thus reduce seizure frequency in a non-invasive manner. This technique involves measuring neurophysiological activity using a technical interface to extract a parameter of interest, … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2026-01-21 |
| 30 | Perceived Stigma, and Social Misconceptions in People With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the educational, occupational, and social challenges experienced by individuals with epilepsy using structured questionnaires developed by the research team. Despite advances in diagnosis and treatment, people with epilepsy may continue to face difficulties related to stigma, access to opportunities, and daily functioning. Participants will complete survey forms designed to assess barriers encountered in school, workplace, and social environments, as well as their perceptions and experiences related to living with epilepsy. The findings are expected to provide insight into unmet needs and inform strategies to improve support and quality of life for individuals with epilepsy. |
SAGLIK BILIMLERI UNIVERSITESI | 2026-03-04 |
| 31 | The Safety and Efficacy Evaluation of Everolimus As An Adjunctive Treatment for Focal Refractory Epilepsy: A Pilot Study Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the clinical efficacy of everolimus as an adjunctive therapy for refractory epilepsy. The significance lies in addressing whether the mTOR inhibitor sirolimus has antiepileptic adjunctive effects for a broader range of patients with refractory epilepsy, with the hope of providing a new mTOR-targeted antiepileptic adjunctive medication regimen that is administered only during epileptic events and can be widely used for various types of refractory epilepsy. |
LIANKUN REN; | 2025-12-15 |
| 32 | Human Hippocampal Oscillations During Visuomotor Exploration PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices. |
ANLI LIU; | 2026-02-27 |
| 33 | Evaluation of Long-term Efficacy of 4 to 6-month Course Antiviral Therapy for Neurodevelopmental Impairments Caused By Congenital Cytomegalovirus Infection: A Multicenter, Randomized, Controlled, Non-inferiority Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Title: Evaluation of Long-term Efficacy of 4-month versus 6-month Course Antiviral Therapy for Neurodevelopmental Impairment Caused by Congenital CMV Infection: A Multicenter, Randomized, Controlled, Non-inferiority Clinical Study 1\. Background and Rationale：Congenital cytomegalovirus (cCMV) infection is a leading cause of childhood neurodevelopmental disability and sensorineural hearing loss (SNHL). International guidelines, based on evidence from high-income countries, recommend a 6-month antiviral course for symptomatic infection. However, clinical practice in China lags significantly, … |
HU BOFEI; | 2026-03-04 |
| 34 | To Explore The Efficacy and Safety of Double-dose Third-generation EGFR-TKI Combined With Bevacizumab and Intrathecal Chemotherapy in Advanced NSCLC Patients With Progressive Leptomeningeal Metastasis After Prior Standard-dose Third-generation EGFR-TKI Treatment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to explore the efficacy and safety of double-dose third-generation EGFR-TKI combined with bevacizumab and intrathecal chemotherapy in treating advanced non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis that progressed after prior standard-dose third-generation EGFR-TKI treatment. It also aims to investigate the correlation between cerebrospinal fluid genetic characteristics and prognosis as well as subsequent efficacy prediction in patients with leptomeningeal metastasis after resistance to standard-dose third-generation EGFR-TKI. The main questions it intends to answer are: Does this combined treatment regimen improve leptomeningeal metastasis response rate (LM-ORR) evaluated by RANO-LM? What adverse events occur in patients during the treatment with this combined regimen? Researchers will conduct a single-arm phase II prospective study to assess the effectiveness and safety of the combined treatment, without a control group comparison. Participants will: Receive double-dose third-generation EGFR-TKI (osimertinib 160mg qd, furmonertinib 160mg qd, or almonertinib 220mg qd) + intrathecal pemetrexed (induction phase: 10mg twice a week for 4 weeks; maintenance phase: 10mg once a week for 4 weeks; consolidation phase: 30mg every 4 weeks until disease progression or intolerable toxicity) + bevacizumab 7.5mg/kg. Undergo screening assessments within 28 days before enrollment, including tumor imaging, laboratory tests, and cerebrospinal fluid examination. During the treatment period, conduct regular checkups and tests (such as blood routine, blood biochemistry, electrocardiogram, and imaging examinations) according to the protocol (once every 4 weeks in the first two treatment cycles, then once every 8 weeks). Complete quality of life assessment using the QLQ-C30 scale every 4 weeks and record changes in neurological symptoms and ECOG scores. |
SECOND AFFILIATED HOSPITAL OF NANCHANG UNIVERSITY | 2026-02-10 |
| 35 | Presca : Prospective Study to Determine The Prevalence of Signs of Central Sensitization in Adults With ASD Without Intellectual Developmental Disorders PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Autism is a neurodevelopmental disorder (NDD) characterized by two key features: persistent deficits in communication and social interaction, and restricted, repetitive patterns of behavior, interests, and activities. Ninety-five percent of children aged 3 to 6 with autism spectrum disorder (ASD) have sensory peculiarities. In adulthood, this figure remains at 90%. This atypical sensory processing has been part of the DSM diagnostic criteria since 2013. Each sense can be affected by hypo- or hypersensitivity. In the continuum of this particular sensory processing, pain, which is defined as an unpleasant sensory and emotional experience, … |
ESTELLE ECR COTTE RAFFOUR; | 2026-03-27 |
| 36 | Vagal Autonomic Stimulation Physiotherapy (With Trigger Point Release) As An Adjunct to Personalized Antihypertensive Management of Gestational Hypertension Syndrome and Preeclampsia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Preeclampsia is one of the most common and serious complications of pregnancy, affecting both the mother and baby. It is a condition characterized by high blood pressure and can lead to severe complications, including neurological issues and reduced blood flow to the placenta. Preeclampsia is responsible for a significant number of maternal and perinatal deaths worldwide, with an estimated 14% of maternal mortality in Mexico linked to this condition. Recent research suggests that disruptions in the body’s autonomic nervous system, specifically the balance between the sympathetic and parasympathetic systems, play a role in the development of preeclampsia. The vagus nerve, … |
CARLOS ALBERTO GARCIA BECERRA; | 2025-12-08 |
| 37 | Neuronal Mechanisms of Learning and Utilizing Abstract Representations PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to examine how memories of past experiences are used to guide behavior in novel situations through the cognitive process of abstraction. This project examines how abstract representations are learned, whether and how they support generalization to novel situations, and whether and how they support analogical reasoning. |
ADAM MAMELAK; | 2026-03-06 |
| 38 | The Role of Transcutaneous Vagus Nerve Stimulation in Neuroprotection and The Reduction of The Systemic Inflammatory Response in Acute Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Acute brain injury is a major global health problem associated with high mortality and morbidity, limited therapeutic options, prolonged hospital stays, and long-term disability that significantly impairs quality of life and increases healthcare costs. Noninvasive transcutaneous VNS developed as a safer approach for treating cerebral edema, epileptic seizures, and blood-brain barrier disruption, for facilitating the recovery of motoric and cognitive functions, and for immunomodulation. Transcutaneous VNS improves cerebral perfusion pressure and tissue oxygenation, supports reperfusion of the penumbral zone, and reduces neuronal hyperexcitability, thereby suppressing seizures.It may exert anti-inflammatory effects by reducing microglial cytokine and chemokine production. Additionally, … |
DINKO TONKOVIĆ; | 2026-02-03 |
| 39 | An Open Label, Single-site Feasibility Study of Transcranial Direct Current Stimulation (tCDS), Using The Nettle Device, for The Treatment of Chronic Migraine PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Migraine affects 1 in 7 people worldwide, but for those suffering from chronic migraine there is a need for safe, effective and well tolerated treatments. The Nettle device is a non-invasive device, which is worn like a headband and delivers electrical stimulation (known as transcranial direct current stimulation or TCDS) to areas of the brain known to be involved in the processing of pain. In this study, … |
UNIVERSITY COLLEGE LONDON | 2025-12-04 |
| 40 | Assessment of Health-Related Quality of Life in Adults With Epilepsy Using The Quality of Life in Epilepsy Inventory (QOLIE-31): A Cross-Sectional Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims to assess quality of life in individuals with epilepsy using the Quality of Life in Epilepsy Inventory (QOLIE-31). A total of 90 adult patients with a clinical diagnosis of epilepsy will be evaluated through standardized questionnaires administered during routine clinical visits. The study seeks to characterize patient-reported quality of life across multiple domains and to provide insight into factors affecting daily functioning and well-being in people living with epilepsy. |
SAGLIK BILIMLERI UNIVERSITESI | 2026-03-12 |
| 41 | Evaluation of The Efficacy and Safety of Cenobamate in Individuals With Autoimmune Epilepsy: A Real-world Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Over the last decades, multiple neuronal autoantibodies directed against intracellular or cell-surface antigens have been identified in association with epilepsy and encephalopathy. In some patients with immune-mediated brain disorders, seizures persist and become chronic despite treatment with antiseizure medications (ASMs) and immunotherapy. This condition is particularly common in patients with antibodies against glutamic acid decarboxylase 65 (GAD65) or onconeural antigens (e.g., Hu, Ma2, and CRMP5/CV2). The persistence of seizures despite immunotherapy suggests the development of a sustained epileptogenic predisposition, … |
PAOLO CALABRESI; | 2026-03-16 |
| 42 | Self-inspired & Tailored Autism Movement With Phystic App PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if watching instructions for daily exercises with three different contents (the patients themselves, other children, or children dressed as rabbits in addition to their physiotherapist, could increase physical activity among children with autism. The main questions it aims to answer are: Are children with autism motivated to engage in daily exercise by seeing themselves in a mobile application? Researchers will compare instructions with the children themselves with instructions containing other children and children in rabbit suits. Parents and their children will use the mobile application once daily for 8 weeks, … |
OSKAR LUNDGREN; | 2026-03-20 |
| 43 | FORESITE (FOREcasting Seizures to Initiate ThErapy): Optimizing Management of Drug-Resistant Epilepsy Using Seizure Forecasts Via Subscalp EEG and Wearables PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety and feasibility of using seizure forecasts based on subscalp EEG. |
BENJAMIN H. BRINKMANN; | 2026-03-19 |
| 44 | Evaluation of The Efficacy and Safety of Anti-angiogenic Therapy With Intravenous Bevacizumab in Patients With Symptomatic Cerebral Arteriovenous Malformations PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Brain arteriovenous malformations (AVMs) are responsible for hemorrhagic strokes, particularly in children and young adults. They can also be responsible for chronic neurological disorders: motor or sensory deficits, disturbances of higher functions, epilepsy or disabling headaches. The management of brain AVMs is complex and requires a multidisciplinary approach in an expert center. Available therapies include endovascular embolization, neurosurgical resection and/or radiosurgery. These procedures carry a risk of neurological complications, and are reserved for small AVMs located at a distance from highly functional cerebral structures. To date, … |
FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD | 2026-01-22 |
| 45 | Evaluation of The Ketogenic Diet to Improve Post Operative Cognitive Decline in Cardiac Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Postoperative cognitive decline (POCD) is a significant neurological problem that commonly follows coronary artery bypass grafting surgery (CABG) in elderly patients. This can result in longer hospital stays and generate worsening morbidity and mortality. Furthermore, POCD often persists in some patients for more than a year and puts them at higher risk for developing Alzheimer’s Disease or dementia. The cause of POCD is a topic of ongoing work, with recent hypotheses linked with cell dysfunction and death in the brain, and neuroinflammation related to the surgical trauma and related systemic inflammation. In this project, … |
ANTOINETTE BURGER; | 2025-06-11 |
| 46 | The Effect of Dual-tasking Program on Cognitive and Physical Functions and Independence in Activities of Daily Living in Children With Duchenne Muscular Dystrophy: A Single-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and frequent developmental, cognitive and behavioral impairments, occurring in one in 5000 live births of boys. DMD is caused by a deficiency of the protein dystrophin, which maintains the structure and functionality of muscle cells. The absence of dystrophin leads to the weakening and eventual death of muscle cells, resulting in reduced muscle strength and impaired motor function. In early childhood, children with DMD may experience delays in basic motor skills such as walking and standing. Later in life, … |
BAŞAK ÇAĞLA ARSLAN; | 2026-01-27 |
| 47 | Mild Cognitive Impairment and Psychopathology: Effects on Awareness, Social Life, and Work. Cross-sectional Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Mild Cognitive Impairment (MCI) is a condition characterized by cognitive deterioration greater than what is expected from normal aging, representing an important risk factor for the development of dementia. Early assessment of cognitive functions is therefore essential for promptly identifying any signs of decline. In addition to cognitive aspects, it is equally important to consider the possible psychopathological profile of patients, as such disorders can significantly influence the progression of the disease, quality of life, and the ability to manage daily activities. This protocol aims to explore the presence of psychopathological disorders in patients with MCI, … |
IRENE CAPPADONA; | 2026-01-22 |
| 48 | The Effect of Transcutaneous Electrical Nerve Stimulation (TENS) on Postoperative Pain and Sleep After Inguinal Hernia Surgery: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates whether Transcutaneous Electrical Nerve Stimulation (TENS) improves postoperative pain and sleep quality in adults undergoing inguinal hernia surgery. After surgery, participants will receive physician-supervised TENS or usual care. Pain intensity and sleep quality will be measured and compared between groups to assess the effectiveness and safety of TENS as a supportive recovery method. |
ABDURRAHMAN ACAR; | 2026-01-06 |
| 49 | Oral Hygiene and Prophylactic Antibiotics to Prevent Intracerebral Hemorrhage Associated Pneumonia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Project Name: Randomized Controlled Clinical Study on oral hygiene and prophylactic antibiotics to prevent Intracerebral Hemorrhage associated pneumonia Research Objectives: To evaluate the effectiveness, safety and health economics value of enhanced oral hygiene combined with antibiotics in preventing post-cerebral hemorrhage pneumonia. 1. To clarify the effectiveness of enhanced oral hygiene combined with antibiotics in preventing post-cerebral hemorrhage pneumonia. 2. To clarify the safety of enhanced oral hygiene combined with antibiotics in preventing post-cerebral hemorrhage pneumonia. 3. To clarify the health economics value of low-intensity enhanced oral hygiene combined with antibiotics in preventing post-cerebral hemorrhage pneumonia. Research Design: Research Type: Multicenter, … |
JUNPING GUO; | 2026-02-12 |
| 50 | The Effects of Combined Transcranial Direct Current Stimulation and Pneumatic Compression on Selected Recovery Parameters After A 10K Run PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will examine how two recovery methods-pneumatic compression (PC) applied to the legs and transcranial direct current stimulation (tDCS) applied to the head-help athletes recover after a 10-kilometer (10K) run. It also aims to find out which methods may help master athletes recover faster, maintain performance, and reduce the risk of injury. Men aged 40-55 who are trained long-distance runners can participate, provided they do not have medical conditions that prevent safe exercise or use of the recovery methods. Participants will run 10K and then receive one of the following interventions in a randomized order: tDCS, PC, … |
RAMIZ ARABACI; | 2026-01-12 |
| 51 | Establishment of A Research Cohort on Sleep and Sleep Disorders in Patients With Neurological Diseases PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to establish a research cohort on sleep and sleep disorders in patients with neurological diseases to systematically evaluate the relationship between various neurological conditions and sleep characteristics or disturbances. |
ZAN WANG; | 2026-01-28 |
| 52 | Cannabidiol for The Treatment of Diabetic Peripheral Neuropathy: Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot study (CBD-DPN1) is a double-blinded, placebo-controlled, crossover pilot study evaluating the efficacy of Cannabidiol (CBD) and full-spectrum CBD (fsCBD) tinctures in treating Diabetic Peripheral Neuropathy (DPN)-associated pain. DPN is a common, highly distressing complication of diabetes, characterized by chronic pain and loss of sensory function, … |
PHILIP R TREADWELL; | 2026-01-15 |
| 53 | A Prospective Cohort Study on Comprehensive Care of Sleep Disordered Breathing (Care-SDB Study) PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The Comprehensive Care of Sleep Disordered Breathing study (Care-SDB) is a prospective, multi-center, registry-based cohort study designed to investigate the integrated management of sleep-disordered breathing (SDB). The investigators aim to establish a nationwide SDB cohort and biobank to identify prognostic biomarkers, explore pathogenic mechanisms, and evaluate optimal treatment models. A total of 11,100 adult patients with recent sleep monitoring will be enrolled and followed longitudinally for up to 5 years. Data collection, including clinical outcomes and major adverse events, … |
SHAO-PING NIE; | 2026-01-21 |
| 54 | Levetiracetam Compared to Magnesium Sulfate for Prevention of Eclamptic Seizure: A Randomized Controlled Trial LEVMag Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to compare levetiracetam to magnesium sulfate for the prevention of eclamptic seizures in pregnant persons with severe preeclampsia that are 32 or more weeks pregnant. This is an equivalence study so our primary goal is to see no difference in the incidence of seizure in the two groups. Since side effects can be a significant problem with magnesium sulfate and these patients are at significant risk of life threatening complications, we also plan to evaluate several secondary outcomes in the mothers and the babies, including: severe allergic reaction, magnesium toxicity, ICU admission, hospital readmission, … |
TODD LOVGREN; | 2025-10-24 |
| 55 | Perioperative Randomized Evaluation of LeVetiracetam’s Efficacy and Safety for Epilepsy Prevention in Neurosurgical Tumor Patients (PREVENT): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Parallel Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the efficacy and safety of levetiracetam for the prevention of postoperative seizures in adult patients undergoing supratentorial brain tumor surgery. It is a multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial. Eligible participants will be randomly assigned in a 1:1 ratio to receive levetiracetam or placebo, starting 1 hour before surgery and continuing for 3 months postoperatively. The primary outcome is the incidence of clinical seizures within 3 months after surgery. Secondary outcomes include subclinical seizures within 7 days and 3 months postoperatively, adverse events within 3 months, … |
WANG JIA; | 2025-11-20 |
| 56 | Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epilepsy Video-EEG Monitoring PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: ProbCluster trial aims at making the proof of concept of antiseizure efficacy of the old antigout PBN in SC, in which Panx1 involvement is relevant on SC pathophysiology and in which efficient therapies are still lacking. The trial will be performed on patients with focal epilepsy in presurgical evaluation undergoing video-EEG monitoring, a setting characterized by a high risk of SC and an efficient video-EEG monitoring of seizures, reducing the risk of erroneous report based on patient home assessment. PBN is a good candidate for a repurposing in epilepsy, … |
FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD | 2026-01-06 |
| 57 | Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in Children With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To Determine the prevalence of ADHD symptoms in children with epilepsy, And find out the possible risk factors of ADHD in such patients and it’s effect on prognosis of the disease |
ASSIUT UNIVERSITY | 2025-10-03 |
| 58 | The Children’s Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): A Pivotal, Randomized, Controlled, Double-blinded Multi-site Clinical Trial of Deep Brain Stimulation to Treat Children With Lennox-Gastaut Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The CADET Trial will investigate the effectiveness of deep brain stimulation (DBS) to reduce the frequency of seizures in children with Lennox-Gastaut syndrome (LGS). The CADET Trial will use a non-CE/UKCA marked device – the Picostim DBS system. The SMART-DBS study is a sub-study of the CADET Trial. SMART-DBS will investigate the application of adaptive DBS for the treatment of children with LGS. Children will be recruited after they exit from either the prior ‘CADET Pilot Study’ or ‘CADET Trial’ – meaning that these children will already be receiving therapy with an already implanted Picostim device. |
UNIVERSITY COLLEGE LONDON | 2025-12-04 |
| 59 | Impact of Canine Mediation Practice in Psychomotor Therapy on Improving The Quality of Life in Adult Epileptic Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In addition to the search for new pharmaceutical or surgical solutions that could improve the therapeutic management of epileptic individuals, it is interesting to ask whether other complementary approaches, such as canine mediation in psychomotor therapy, could enhance the quality of life in this population. However, there is currently no evidence indicating that exposure to animals through mediation sessions would be beneficial for epileptic individuals, particularly regarding their quality of life, anxiety, emotional management, or cognition (such as social cognition). In the absence of current data in this population, … |
FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD | 2025-12-17 |
| 60 | Impact of Epilepsy on The Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Despite the continuous development of new antiseizure medications over the past 25 years, 30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, like cognitive dysfunctions, sleep-disordered breathing or Sudden and Unexpected Death in Epilepsy (SUDEP). SUDEP typically occurs during sleep, after a nocturnal seizure, and primarily results from a postictal central respiratory dysfunction in patients with generalized convulsive seizure (GCS), … |
SYLVAIN RHEIMS; | 2025-11-25 |
| 61 | Yoga for Treatment of Overactive Bladder in Pediatric Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pilot study is to assess the impact of yoga as a treatment modality in pediatric patients age 8-18 diagnosed with idiopathic overactive bladder as measured by validated questionnaires and urinary biomarkers. The main question it aims to answer is: Does yoga help improve overactive bladder symptoms in this patient population? Participants will take part in a weekly yoga session for a total of 6 weeks with validated questionnaires and urinary samples for biomarkers to be completed at the beginning, … |
DUKE UNIVERSITY | 2026-01-30 |
| 62 | Muscarinic Agonist Modulation of Memory Processing Oscillatory Activity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to learn about the effects of Cobenfy KarXT (xanomeline and trospium chloride) on episodic memory processing, including specific effects on areas of the brain involved in memory and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether Cobenfy KarXT changes memory activity based on its agonist effect on muscarinic receptors and acetylcholine, … |
BRADLEY LEGA; | 2025-11-26 |
| 63 | Compassion Focussed Therapy Informed Psychoeducation and Loving Kindness Meditation for Children and Young People With Epilepsy Related Papers Related Patents Related Grants Related Experts Highlight: It has frequently been shown that people with long term physical health conditions, like epilepsy, are more likely to have mental health conditions. Studies have shown people with epilepsy report high levels of shame, stress, social isolation and anxiety. Mental health interventions for people with epilepsy, particularly children, … |
NIMA MOGHADDAM; | 2025-12-04 |
| 64 | Outcomes of Drug Resistant Epileptic Pediatric Patient By Modified Atkins Diet PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To assess clinical outcomes in drug resistant epileptic pediatric patient by modified atkin diet with focusing on following points: 1. Control of seizures(frequency , duration and numbers of hospital admissions) . 2. Quality of life by pediatric quality of life inventory v4. 3. Cognitive function by stanford binet intelligence scale 5th edition. 4. Growth parameters ( weight, height will be combined to report BMI in kg/m\^2). |
MAHMOUD SABER ELSAYED; | 2025-12-10 |
| 65 | Predictors of Anti-seizure Medication Resistance in Pediatric Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. This study aims to determine the main predictors of drug resistance in pediatric epilepsy by examining clinical data, EEG abnormalities, and neuroimaging results, in order to support early identification of resistant cases and improve treatment strategies . 2. Early introduction of new lines of treatment in case of refractory epilepsy as : Ketogenic diet , Rituximab and solumedrol |
DALIA ABDELRAHIM FAKHRY HUSSEIN; | 2025-12-17 |
| 66 | A Phase II Randomized Open-Label Trial of Levetiracetam for Prevention of Seizures in Patients With Brain Metastases in Primary Motor Cortex PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized trial for patients with brain metastases in the primary motor cortex who have not had seizures to receive either the prophylactic anti-seizure medication levetiracetam (also known by its trade name Keppra) or proceed with standard of care management, which does not currently include prophylactic levetiracetam. Patients who enroll to this trial will be randomized to receive prophylactic levetiracetam or not receive prophylactic levetiracetam. |
AYAL A. AIZER; | 2026-03-19 |
| 67 | A Prospective Study to Evaluate The Use of The Minder Device to Aid in Developing A Treatment Plan After Inconclusive Prolonged EEG in Patients With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research is to address the challenges of diagnosing and long-term management of epilepsy in participants whose seizures are not well captured by standard electroencephalography (EEG) tests and who cannot use or are not able to use more standard monitoring techniques. This research will compare the Minder System to standard of care in providing reliable seizure data. The Minder System was granted De Novo classification by the U.S. Food and Drug Administration (FDA) and is not investigational. Participants will consent to join the study and be implanted with the Minder device; … |
CORNEILA DREES; | 2026-04-01 |
| 68 | A Phase III, Randomized, Double-blinded Study of The Efficacy and Safety of LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer’s Disease in Adults With Down Syndrome (the LESS-AD Trial) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate whether levetiracetam can prevent epileptic seizures in patients with Alzheimer’s disease associated with Down syndrome. It will also analyze whether it can delay the neurodegeneration associated with this disease. Patients will be randomly assigned to one of two groups: one group will receive the active drug (levetiracetam), and the other will receive a placebo. Both groups will receive the treatment for 96 weeks. Each patient will participate for a total of 2 years and 5 months. |
FUNDACIÓ INSTITUT DE RECERCA DE L’HOSPITAL DE LA SANTA CREU I SANT PAU | 2026-01-12 |
| 69 | The Effect of Virtual Reality-Based Episiotomy Simulation on Midwifery Students’ Skills and Self-Efficacy Levels PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to develop and evaluate a virtual reality (VR)-based episiotomy training simulation for midwifery students. Episiotomy is a surgical procedure performed during childbirth, and incorrect application may lead to serious psychological and physiological consequences. While traditional training methods often use animal tissues or synthetic materials, recent advances in technology have introduced simulation-based learning. VR technology has shown potential to enhance learning outcomes, confidence, and satisfaction among healthcare students. Despite its growing use in medical education, there is currently no VR training model specifically designed for teaching episiotomy skills. This study will design a VR episiotomy simulation, … |
SIBEL AKGÜL KARTAL; | 2025-11-19 |
| 70 | The Impact of Medical TV Drama in Improving Literacy on Neurocysticercosis: An Online Open-Label Two-Arm Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial evaluates whether exposure to a medical television drama improves knowledge of neurocysticercosis (NCC) among young adults. Sixty participants aged 18-35 will be randomly assigned to either an intervention group, which will watch a medically relevant TV episode (House M.D., Season 1, Episode 1), or a control group with no media exposure. Both groups will complete pre- and post-test questionnaires assessing knowledge of NCC. The primary outcome is change in NCC-related knowledge. Secondary outcomes include motivation to seek further health information and perceived credibility of the media source |
EMEKA OKEKE; | 2025-12-04 |
| 71 | Effect of Biofeedback-Enhanced Exergaming, Exergaming Alone, and Traditional Physical Therapy on Motor Function, Adherence, and Engagement in Children With Cerebral Palsy (GMFCS I-II): A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebral Palsy (CP) accounts for approximately 0.9% of the global disease burden and affects 2.4-4% of children under 5 years old, with associated developmental and coordination impairments. Pediatric physical therapy aims to enhance independence and quality of life; however, maintaining adherence to conventional treatment remains a major challenge due to its repetitive and monotonous nature, leading to reduced motivation and limited functional progress. Exergaming, integrating physical activity with interactive video games, has emerged as an engaging alternative shown to improve motor function, balance, and coordination in children with motor impairments. While existing evidence supports its effectiveness, … |
SAJID IQBAL; | 2026-01-08 |
| 72 | Intermittent Theta-Burst Stimulation Targeting The Prefrontal Cortex for Social Anxiety Disorder: A Randomized, Parallel-Group Comparative Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the therapeutic effects of intermittent theta burst stimulation on social anxiety disorder and to track physiological changes in the brain using electroencephalography (EEG). Eligible SAD participants, after voluntarily signing an informed consent form, will first complete basic information collection, baseline questionnaire completion, and a pre-treatment EEG data collection session lasting approximately 30 minutes (including resting-state and task-state recordings). Subsequently, participants will be randomly assigned to one of three groups (left iTBS group, right iTBS group, or sham stimulation group) to receive intensive treatment for one week (4 sessions daily for 5 consecutive days, … |
LEI LEI ZHENG; | 2026-03-12 |
| 73 | A Single-center, Prospective, Single-arm Clinical Study: Evaluation of The Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) for Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder (NMOSD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label, single-arm, single-center prospective pilot study to assess the efficacy and safety of transcranial temperol interference stimulation in patients with neuromyelitis optica spectrum disorder (NMOSD) complicated by neuropathic pain in China. |
JUN GUO; | 2026-01-29 |
| 74 | Dementia and Mild Cognitive Impairment: Assessment of Cognitive Functioning, Functional Autonomy, and Neuropsychiatric Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Dementia, in its various forms, is characterized by a generalized cognitive decline that can significantly compromise personal autonomy and quality of life. Mild Cognitive Impairment (MCI), although not classified as an overt form of dementia, represents a condition at evolutionary risk and is considered a crucial transitional stage for the early detection of cognitive decline. Understanding the impact of dementia and MCI from a multidimensional perspective is now essential to fully grasp the repercussions of these conditions on patients’ daily lives. The present protocol aims to investigate key aspects related to these disorders, with the objective of exploring cognitive functioning, … |
FRANCESCO CORALLO; | 2025-12-17 |
| 75 | Application of An AI-Based Health Management System in Long-Term Epilepsy Management in Rural Areas PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project, titled Application of an AI-Based Health Management System in Long-Term Epilepsy Management in Rural Areas , is led by the First Affiliated Hospital of Air Force Medical University, with Jiang Wen as the principal investigator. It is a prospective, multicenter, … |
XIJING HOSPITAL | 2026-03-04 |
| 76 | Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Surgical Anxiety, Postoperative Pain, and Patient Satisfaction in Patients Undergoing Laparoscopic Cholecystectomy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed to evaluate whether Transcutaneous Electrical Nerve Stimulation (TENS) can improve recovery for patients undergoing laparoscopic gallbladder removal surgery (laparoscopic cholecystectomy). TENS is a non-invasive method that uses mild electrical currents applied through the skin to stimulate nerves. The main goals of the study are to determine if TENS can: Reduce surgical anxiety before and during the procedure Decrease postoperative pain after surgery Improve overall patient satisfaction with their surgical experience Patients who participate will receive standard surgical care, … |
ABDURRAHMAN ACAR; | 2025-12-29 |
| 77 | A Study to Evaluate The Safety and Effectiveness of Magnetic Resonance-Guided Ultrasound Ablation of The Anterior Nucleus of Thalamus for The Treatment of Drug-resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study Safety and Efficacy Evaluation of MR-Guided Focused Ultrasound Anterior Thalamic Nucleus Ablation for Drug-Resistant Epilepsy from Chinese PLA General Hospital, is a single-center, prospective, single-arm study. It uses a MR-guided Focused Ultrasound Therapy System and plans to recruit 20 patients with drug-resistant epilepsy who are ≥20 years old, have a WAIS score ≥70, an average of ≥3 monthly epileptic seizures in the 3 months before enrollment, and are refractory to at least 2 antiepileptic drugs (including 1 first-line drug), excluding those with unstable cardiac function, brain tumors, previous brain surgery history, … |
LONGSHENG PAN; | 2025-11-25 |
| 78 | Clinical Study on The Safety, Tolerance and Preliminary Efficacy of Human Mesenchymal Stem Cell Therapy for Parkinson’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study, through different administration methods, adopted a randomized, double-blind, placebo-controlled trial design to evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells (hUC-MSCs) in patients with Parkinson’s disease, explore their initial effectiveness and the relationship between biological active factors and therapeutic efficacy. The Clinical Study on the Treatment of Parkinson’s Disease with Human Umbilical Cord Mesenchymal Stem Cells of this study is expected to provide clinical trial evidence for the development of safe and effective clinical cell therapies for patients with Parkinson’s disease. |
LIAONING MEDICAL DIAGNOSIS AND TREATMENT TECHNOLOGY RESEARCH AND DEVELOPMENT | 2025-11-18 |
| 79 | A Phase 1/2 Open-Label Intrathecal Administration of TSHA-105 to Determine The Safety and Efficacy in 2 Subjects With SLC13A5 Citrate Transporter Disorder Caused By A Mutation in The SLC13A5 Gene Related Papers Related Patents Related Grants Related Experts Highlight: Phase 1/2, open-label study to assess the efficacy and safety of a single lumbar intrathecal administration of TSHA-105 in individuals with SLC13A5 Citrate Transporter Disorder |
DALLAS ARMSTRONG; | 2025-08-14 |
| 80 | The Effects of TRanscranial AlterNating Current Stimulation FOR Patients With Mild Alzheimer’s Disease II (TRANSFORM-AD II Study): A Randomized Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to explore the efficacy and safety of transcranial alternating current stimulation (tACS) in patients with amnestic mild cognitive impairment due to Alzheimer’s disease (AD-aMCI) and patients with mild Alzheimer’s disease dementia (AD-MD). The study will recruit 160 individuals with mild cognitive impairment with evidence of amyloid plaques in the brain through Positron Emission Tomography (PET) imaging. Participants will undergo baseline cognitive assessment, structural and functional MRI characterization, PiB-PET, and EEG measurement. The participants will be randomized to either a tACS group or a sham stimulation group. At the end of the intervention, … |
YI TANG; | 2025-11-17 |
| 81 | Cilostazol for Preventing Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: A Prospective, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators propose to conduct a multicenter randomized trial to test whether cilostazol reduces the incidence of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) and improves patients’ neurological prognosis, while assessing its safety. |
BEIJING TIANTAN HOSPITAL | 2025-11-25 |
| 82 | An Open Label Pilot Study of Infrared Photobiomodulation in Humans With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Drug-resistant epilepsy represents roughly 40% of people with epilepsy. It is very challenging to stop seizures in this condition, and the treatment options are limited. This study aims to investigate a new treatment that involves using infra-red light. In animals, this treatment has shown promise as a possible way to reduce seizures, but it has not been tested in humans for this. The investigators are interested to know if it can reduce seizures, and how comfortable it is to be treated with this therapy. |
DANIEL GOLDENHOLZ; | 2026-02-04 |
| 83 | Centromedian Deep Brain Stimulation Vs. Vagus Nerve Stimulation for The Treatment of Drug-Resistant Epilepsy and Epileptic Spasms in Children: A Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Deep Brain Stimulation vs. Vagus Nerve Stimulation for the Treatment of Drug-Resistant Epilepsy and Epileptic Spasms in Children: A Randomized Control Trial |
GEORGE IBRAHIM; | 2025-06-12 |
| 84 | Comparative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation on Upper Limb Function, Cognition and Quality of Life in Subacute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to determine whether transcutaneous vagus nerve stimulation (tVNS) via auricular or cervical branches enhances recovery when combined with task-specific training in subacute stroke patients. We anticipate finding that both stimulation methods may improve upper limb motor function compared to conventional therapy. The research is expected to reveal specific cognitive domains (attention, memory, executive function) that benefit most from each stimulation approach, … |
ARUBA SAEED; | 2025-12-03 |
| 85 | An Exploratory Clinical Trial of UX-GIP001 Injection (Human GABAergic Interneuron Progenitor Cells Injection) in Adult Patients With Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy Related Papers Related Patents Related Grants Related Experts Highlight: This is an exploratory clinical trial (Protocol: UX-GIP001-101) investigating UX-GIP001 Injection, a novel cell therapy product consisting of human GABAergic interneuron progenitor cells (GIP), for treating adult patients with drug-resistant unilateral medial temporal lobe epilepsy (MTLE). The primary objective is to assess the safety, tolerability, and preliminary efficacy of UX-GIP001. This is an open-label, single-arm study. All enrolled participants will receive the active investigational cell therapy. Seizure frequency and safety parameters will be evaluated by comparing post-transplant outcomes to pre-transplant baselines. |
SHUANG WANG; | 2025-11-24 |
| 86 | National Survey on Physical and Sports Activity of Adults With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Epilepsy affects nearly 600,000 people in France and causes neurological seizures that can lead to lasting impairments and stigma. Physical activity provides many benefits, including improved quality of life, social participation, and reduced stress and seizure frequency. Despite these benefits, people with epilepsy tend to be less active than the general population due to barriers such as fear of seizures during exercise, fatigue, and negative beliefs about the disease. Psychological factors and stigma influence physical activity engagement and affect how the disease is integrated into personal identity, impacting quality of life and treatment adherence. Studying the role of anxiety, stigma, … |
FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD | 2025-12-10 |
| 87 | Epilepsy and Driving PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Epilepsy can lead to cognitive impairments, particularly in attention, which may affect daily activities such as driving. Driving plays a key role in maintaining autonomy and is essential for the social and professional integration of people with epilepsy. Therefore, assessing fitness to drive is a major issue for individuals with epilepsy. French legislation governing driving for people with epilepsy clearly outlines the periods during which a person is not permitted to drive. However, the means or methods for evaluating driving fitness in these individuals are not well defined. Currently, … |
FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD | 2025-12-17 |
| 88 | Effects of A Six-Week Stroboscopic Training Program on Agility and Reactive Agility in Adolescent Male Basketball Players: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this pilot study was to investigate the effects of a stroboscopic training intervention on reactive agility and agility speed in basketball players, using identical movement patterns, and to evaluate perceptual-cognitive indices derived from the relationship between agility and reactive agility performance. This study hypothesized that stroboscopic visual training would significantly improve reactive agility and agility performance in adolescent male basketball players. |
BIRGÜL DINGIRDAN; | 2026-02-13 |
| 89 | Evaluation of The Efficacy of Neuromodulation in The Control of Chronic Orofacial Pain: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic orofacial pain significantly affects patients’ quality of life, compromising essential functions such as chewing and speech. Although conventional treatments are available, many patients do not achieve adequate and lasting relief. This project investigates the effectiveness of neuromodulation techniques, namely transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS), … |
EGAS MONIZ COOPERATIVA DE ENSINO SUPERIOR CRL | 2026-02-20 |
| 90 | Open Label Extension Clinical Trial of Vormatrigine in Adult Patients With Epilepsy PF:4 Related Papers Related Patents Related Grants Related Experts Abstract: An open label extension clinical trial to assess the safety and tolerability of vormatrigine in adults with focal or primary generalized tonic-clonic seizures. Incidence and … |
PRAXIS PRECISION MEDICINES | 2025-12-17 |
| 91 | Effectiveness of Virtual Reality Digital Therapeutics for Seasonal Affective Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Seasonal Affective Disorder (SAD) is commonly treated with bright light therapy. Virtual reality (VR) is an immersive computer-generated environment, which has been used to treat mental health difficulties, such as depression, social anxiety and stress. This study aims to compare the use of VR with bright light therapy in treating SAD. Participants will be randomly allocated to either the VR condition or the light box condition and instructed to use the respective device every day for 14 days. |
DEBORA DE VASCONCELOS E SA; | 2025-09-08 |
| 92 | A Proof-of-Concept, Multicentre, Phase IIb, Randomized Double-Blind Crossover Trial of Levetiracetam Vs Placebo for Hippocampal Hyperactivity in Cognitively Normal Individuals at Risk for Alzheimer’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to investigate whether very small doses of a drug called levetiracetam (LEV) may reduce abnormal brain signaling in individuals who are at an increased risk for developing Alzheimer’s Disease (AD). The study is looking for individuals who have a parent or sibling with Alzheimer’s disease (dementia), and who have memory complaints but are currently performing within normal limits on cognitive testing. During the screening period, … |
SANDRA E. BLACK; | 2026-03-17 |
| 93 | Shared Subcortical Arousal Systems Across Perceptual Modalities PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a multi-site study and will be conducted at up to 11 investigative sites in the United States. The study will investigate subcortical arousal circuits in visual perception using techniques with complementary strengths based on promising initial studies. |
HAL BLUMENFELD; | 2026-04-02 |
| 94 | Neuromodulation Using Low-intensity Focused Ultrasound for Potential Treatment for Medically Refractory Temporal Lobe Epilepsy Related Papers Related Patents Related Grants Related Experts Highlight: This study is an invite only study looking at the effects of Low-Intensity Focused Ultrasound (LIFU) on epilepsy patients with implanted electrodes under the care of Dr. Shah. |
AASHIT SHAH; | 2026-01-21 |
| 95 | Efficacy and Safety of Perampanel in The Treatment of Refractory Status Epilepticus Related Papers Related Patents Related Grants Related Experts Highlight: This project is aiming to better understand the use of perampanel as an appropriate standard-of-care therapy for treatment refractory status epilepticus (RSE), to identify determinants of outcomes, and establish safety. The study will recruit 25 patients at WSU. The study will last for about 96 weeks and will involve a screening visit and two in clinic visits at 3 and 6 months. If the subjects give written informed consent and meet all eligibility criteria they will be clinically evaluated and will be given the study drug. This study will involve recording of patients medical history, … |
MAYSAA BASHA; | 2025-10-14 |
| 96 | Therapist-Guided Internet-Delivered Cognitive Behaviour Therapy (CBT) for Chronic Conditions (Chronic Conditions Course; CCC): Single-Group Predictors of Change in Routine Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic health conditions are common, disabling, and often co-occur with depression and anxiety. Internet-delivered cognitive behaviour therapy (ICBT) reduces barriers to treatment and has been adapted for chronic conditions. A transdiagnostic approach is promising because it is both effective and convenient in that clients with diverse conditions receive the same program. Both therapist-guided and self-guided formats have been found effective; however, … |
HEATHER HADJISTAVROPOULOS; | 2025-12-02 |
| 97 | BHV-7000 Efficacy Against Epileptiform Activity in Patients With Epilepsy Implanted With RNS Related Papers Related Patents Related Grants Related Experts Highlight: This is an open label study to assess the biological effect of BHV-7000 on abnormal activity recorded by the RNS System in patients with focal epilepsy implanted with the RNS System. BHV-7000 is a potassium channel activator being evaluated for use in epilepsy. Participants are offered the drug for 4 weeks. Activity during that treatment period is compared to a 90-day retrospective baseline period in which other medications and device settings were stable, and also to a 4-week withdrawal period after treatment is discontinued. The study is open to patients with RNS regardless of whether they report clinical seizures, … |
IMRAN QURAISHI; | 2026-03-09 |
| 98 | Investigation of Postural Parameters, Physical Functions, Balance and Quality of Life in Different Hip Pathologies PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: It is known that pelvic parameters affect physical hip functions in hip pathologies. Depending on the type and severity of hip pathologies, posture, muscle strength, balance, and pain parameters may change, thereby impacting an individual’s quality of life. This study aimed to examine the postural parameters, muscle strength, balance, quality of life, pain intensity, and pain localization of individuals with different hip pathologies, including hip osteoarthritis, hip impingement syndrome, hip labrum tear, hip dysplasia, and hip avascular necrosis. |
ESRA ATEŞ NUMANOĞLU; | 2025-12-18 |
| 99 | Evaluating Efficacy and Tolerability of Three Times Daily Levetiracetam in Epilepsy Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this clinical trial is to evaluate the efficacy and tolerability of Levetiracetam administered three times daily in patients with epilepsy. The primary objective is to investigate whether orally administered Levetiracetam three times daily dosing is superior in seizure-free days compared to standard twice-daily dosing in patients with epilepsy. Key questions include: * Does LEV improve seizure control, as measured by seizure-free days? * What adverse events or safety concerns are observed with LEV treatment? Participants will receive Levetiracetam administered three times daily during the treatment phase. The study will use a self-matched, … |
WAAD ALKATHIRI; | 2026-03-24 |
| 100 | Prospective Evaluation of Probabilistic Predictions of Epileptic Seizure Risk Using The EPIDAY Tool PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Studies suggest the existence of a pre-critical state preceding the onset of an epileptic seizure. Identifying these states from self-reported prodromal symptoms, combined with machine learning algorithms, could help anticipate seizures. |
LOUIS COUSYN; | 2025-09-15 |
| 101 | Electrocardiographic Changes Associated With Epilepsy in Children Attending Assiut University Children’s Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Identify and characterize electrocardiographic (ECG) changes occurring during the post-ictal phase of epileptic seizures. Evaluate the duration and severity of post-ictal ECG abnormalities. Assess the correlation between ECG changes and seizure type, duration, and severity. Explore the association of ECG changes with patient demographics |
SAMAAN REZK GAD EL KARIEM; | 2025-08-22 |
| 102 | Observation of The Effects of Virtual Reality-Assisted Intraoperative Sensory Modulation on Postpartum Depression, Cognitive Function, and The Kynurenine Pathway PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The research will be conducted as a prospective, observational, and comparative study with 98 pregnant volunteers aged 18-45 at Düzce University Faculty of Medicine. Participants will be divided into a VR group and a control group. Data will be collected using STAI-I, EPDS, NRS scales, and biochemical analyses (tryptophan, kynurenine, etc.). Upon completion, the project is expected to contribute to non-pharmacological approaches and new care protocols for reducing postpartum depression. |
DUZCE UNIVERSITY | 2025-12-23 |
| 103 | Echocardiographic and Electrocardiographic Findings in Pediatric Patients With Neurological Findings PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Evaluate the echo-electrocardiographic findings in patients with neurological affection to identify potential cardiac involvement, and explore correlation between cardiac and neurological abnormalities.Objectives are To assess echocardiographic findings in patients with neurological affection , to analyze ECG patterns in the same patient group and to explore clinical significance of detected cardiac findings in the management of neurological patients. |
ANDREW YOUSSEF QESTANDY YOUSSEF; | 2025-09-19 |
| 104 | UltraSONIC Vagus Nerve Stimulation: Investigation U-VNS Effects on Physiological, Emotional and Cognitive Biomarkers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Vagus nerve, one of 12 cranial nerves that connect the brain to the human body, controls specific involuntary functions such as breathing, heart rate, the digestive system and the immune system, and it is crucial to unlocking the relaxation response (parasympathetic nervous system). Vagus nerve stimulation (VNS) can be invasive or non-invasive, and both methods have been trialled in research studies. Some non-invasive VNS involves the use of a device which is placed on the skin, … |
MARCUS KAISER; | 2025-12-16 |
| 105 | A Triple-Blind, Placebo-Controlled, Randomized Clinical Trial of CANnabinoids for Drug Resistant Epilepsy in Adults and Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Epilepsy is a neurological disorder affecting more than 50 million people globally, including more than 260,000 Canadians. Cannabidiol (CBD) reduces seizure frequency and improves quality of life for adults and children with Drug Resistant Epilepsy (DRE). Several uncontrolled, small, open label studies reported that CBD-enriched Cannabis Herbal Extract (CHE) resulted in a reduction of seizure frequency, but we lack critical information on efficacy, comparative effectiveness and dosing of CBD and ∆9-tetrahydrocannabinol (THC) in children and adults with DRE. CAN-DRE is an early phase, triple-blind, placebo-controlled, … |
LAUREN KELLY; | 2025-06-17 |
| 106 | Immersive Functional Virtual Reality in People With Acquired Brain Injury and Unilateral Spatial Neglect: A Feasibility and Usability Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Unilateral spatial neglect (USN) is a common and highly disabling condition following acquired brain injury (ABI), significantly impairing individuals’ ability to perform daily activities and reducing their autonomy. It frequently affects patients who have suffered a stroke or traumatic brain injury, and it is often associated with worse functional outcomes and increased care needs. Despite advances in neurorehabilitation, conventional assessment and treatment tools for USN have shown limitations in sensitivity and ecological validity. Immersive Functional Virtual Reality (IFVR) is an emerging and promising technology that creates controlled, interactive environments, … |
JOSAN MERCHAN; | 2025-06-12 |
| 107 | Prospective, Long Term, Observational Study (Patient Registry) of Paediatric Myotonic Disorders From Birth to Less Than Six Years of Age Who Are Treated With Mexiletine (PEGASUS Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, open-label, multi-centre, single arm, registry study to collect standard relevant clinical and epidemiological data during routine medical evaluation and treatment in paediatric patients with myotonic disorders who are being treated with mexiletine therapy according to the physician. |
CATHARINE SARRET; | 2025-09-23 |
| 108 | Assessment of Kidney Function in Patients With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This observational cross-sectional study aims to assess kidney function in pediatric patients with epilepsy attending Sohag University Hospital. The study evaluates renal biochemical markers, urinalysis, liver functions, abdominal ultrasonography, and the possible renal effects of long-term antiepileptic drug (AED) therapy. |
MOHAMED HASSAN AHMED; | 2025-12-17 |
| 109 | Prevalence and Clinical Impact of Sleep-Disordered Breathing in Children With Cerebral Palsy at Increased Risk of Respiratory Disorders PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Currently, there are few and qualitatively unsatisfactory epidemiological data on the prevalence of sleep-disordered breathing (SDB) in children with cerebral palsy (CP). The investigators aim to conduct a multicentre retrospective study to assess the presence of SDB in children with CP undergoing sleep studies (polysomnography or polygraphy). |
GUIDO CAMANNI; | 2025-07-28 |
| 110 | Prevalence of Neurodevelopmental Disorders in A Homeless Population – Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction \& Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder). Methods / approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, … |
CAROLINE DEMILY; | 2025-08-01 |
| 111 | Safety, Usability, and Effectiveness of A Gait Exoskeleton for Children and Adolescents With Neurodevelopmental Disorders PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Neurodevelopmental disorders often result in abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as the inability to stand and walk. CLINICAL EXPLORER is a clinical-use robotic device for gait training, representing the evolution of the ATLAS 2030 exoskeleton and the EXPLORER device for home use. The aim of this study is to evaluate the safety and usability of CLINICAL EXPLORER . |
MARSIBIONICS | 2025-09-08 |
| 112 | Piriform Cortex Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Piriform cortex as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy with bilateral hippocampal sclerosis |
LIANKUN REN; | 2025-08-19 |
| 113 | An Open-Label, Non-Randomized Study to Evaluate The Efficacy and Safety of ASO-GNAO1 (Tianasen) in Patients With GNAO1-Encephalopathy With Epilepsy and Movement Disorders Following Repeated Intrathecal Dose Escalation Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the efficacy and safety of the investigational drug ASO-GNAO1 (Tianasen) in pediatric patients with c.607G\>A mutation in the GNAO1 gene associated with epilepsy and neurodevelopmental disorder. The main questions it aims to answer are: 1. Does intrathecal administration of ASO-GNAO1 slow or halt the progression of motor and cognitive symptoms? 2. Is ASO-GNAO1 safe and well-tolerated in this patient population? 3. What is the appropriate therapeutic dose? This is an open-label study without a placebo control group due to the rare and severe nature of the disease. All participants will receive the active drug. Participants will: Receive escalating doses of ASO-GNAO1 via intrathecal injection over a 12-month period. Undergo frequent neurological assessments, biomarker testing, and safety monitoring. |
ELENA D BELOUSOVA; | 2026-01-23 |
| 114 | Accelerated, Left Prefrontal Transcranial Magnetic Stimulation for Functional Seizures; An Open-Label Exploration of Feasibility, Tolerability, and Preliminary Efficacy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this project is to assess the feasibility, tolerability, and preliminary efficacy of using an accelerated, intermittent theta burst stimulation (a-iTBS-rTMS) protocol targeting the left dorsolateral prefrontal cortex (l-dlPFC) for Psychogenic Non-Epileptic Seizures (PNES) or Seizure-Type Functional Neurologic Disorder (FND-seiz) in an open-label fashion. Following screening, consent, and enrollment, participants will receive 6-to-10 iTBS-rTMS sessions per day (i.e., theta burst; 600 pulses per session; … |
JOSEPH CHASEN; | 2025-09-22 |
| 115 | Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder with extensive clinical and genetic heterogeneity that is still poorly understood. The phenotype includes hypotonia, delayed psychomotor development, intellectual disability of varying severity, and consistent language impairment ranging from delayed to absent speech. Autism spectrum disorders are present in 60-80% of patients, and other comorbidities may be present. The major candidate gene for PMS is SHANK3, which encodes a scaffolding protein in the dense postsynaptic region of glutamatergic synapses. Its loss of function is caused by deletions in the distal region of chromosome 22, 22q13.3, or by intragenic genomic variants. Several studies, … |
ANNE-CLAUDE TABET; | 2025-08-13 |
| 116 | Safety and Efficacy of Butylphthalide Soft Capsules for Cognitive Impairment Comorbid With Focal Epilepsy in Elderly Patients: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, double-blind, placebo-controlled trial evaluating the safety and efficacy of butylphthalide soft capsules for treating cognitive impairment in elderly patients with focal epilepsy. Study Population: 220 elderly patients (60-85 years) with focal epilepsy and mild to moderate cognitive impairment (Montreal Cognitive Assessment score 18-25). Intervention: Participants will be randomly assigned 1:1 to receive either butylphthalide soft capsules (0.2g three times daily) or matching placebo for 48 weeks, … |
HUIQIN XU; | 2025-09-25 |
| 117 | A Multi-center and Multidisciplinary Research Project on Prevention, Early Detection, and Clinical Evaluation of Intracranial Hemorrhage in Preterm Infants PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. Establish a reference curve for the lateral ventricular diameter of premature infants and determine the intervention threshold for hydrocephalus after hemorrhage in premature infants based on the reference curve, providing a scientific basis for optimizing clinical intervention. 2. Apply ultrasound radiomics technology to explore and formulate new standards for imaging diagnosis and treatment; By integrating metabolomics, ultrasound radiomics and clinical data, … |
SECOND AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY | 2025-09-05 |
| 118 | PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis (PISTIAS-2): A Multicenter, Open-label, Blinded-endpoint, Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, multicenter, open-label, blinded-endpoint, randomized controlled trial designed to evaluate the efficacy and safety of PCSK9 inhibitor combined with statin therapy compared to statin monotherapy in reversing asymptomatic intracranial atherosclerosis, assessed using high-resolution magnetic resonance imaging of the intracranial vessel walls. |
WEI-HAI XU; | 2025-08-07 |
| 119 | Effectiveness of Low-Level Laser Auriculotherapy in The Treatment of Myogenic Temporomandibular Disorders and Anxiety: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Summary: Low-level laser auriculotherapy (LLLT-AT) is a non-invasive technique that has gained attention for managing musculoskeletal pain and anxiety. Given the painful and emotional components of temporomandibular disorders (TMD), LLLT-AT may offer therapeutic benefits by stimulating auricular points associated with pain modulation and anxiety reduction. This randomized, placebo-controlled, two-arm clinical trial with blinded outcome assessors aims to evaluate the effects of LLLT-AT in individuals diagnosed with myogenic TMD (Axis I, … |
HERNÁN A DE LA BARRA; | 2025-08-15 |
| 120 | Safety and Effectiveness of Biomarker Targeted Stimulation in Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, prospective, controlled study designed to evaluate treatment with the BTS System. |
CADENCE NEUROSCIENCE | 2025-02-21 |
| 121 | Glioma Intraoperative MicroElectroCorticoGraphy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to validate the safety and to assess the quality of the signals provided by newly developed micro ElectroCorticoGraphy electrodes, provided by the company Panaxium, based on conductive polymers (PEDOT:PSS) in patients suffering of gliomas during resection surgery performed in awake condition. The main questions it aims to answer are: * Safety of PEDOT:PSS microECoGs by assessing the rate of serious adverse events associated with their use during glioma surgery. * Quality of PEDOT:PSS microECoGs recordings, as compared with recordings with traditional macroelectrodes, assessed by signal-to-noise ratio, impedance, … |
GILLES HUBERFELD; | 2025-03-12 |
| 122 | Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Concurrent electroencephalography (EEG) and new tripolar EEG (tEEG) will be recorded from adult and pediatric patients. In some patients stereo EEG (sEEG) will also be recorded concurrently. |
SUSAN HERMAN; | 2025-12-17 |
| 123 | Multimodal PET Imaging With 18F-FDG/SV2A/TSPO for Resection Planning in Drug-Resistant Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study focuses on the application value of 18F-FDG, SV2A, and TSPO PET imaging in the preoperative localization of epileptogenic foci in epilepsy. 18F-FDG PET detects glucose metabolism in brain tissue and is characterized by reduced metabolism during the interictal period. It is currently the most commonly used localization method in clinical practice, especially suitable for temporal lobe epilepsy, but has limited sensitivity to foci with insignificant metabolic changes. SV2A PET targets synaptic vesicle proteins and reflects synaptic density, showing reduced uptake in epileptogenic foci areas. It has high localization accuracy, can effectively supplement the diagnosis of 18F-FDG PET-negative cases, … |
WEIBING MIAO; | 2025-08-29 |
| 124 | Transcranial Magnetic Stimulation in Anorexia Nervosa: A Double-Blind Randomized Study on The Efficacy of Intermittent Theta Burst Stimulation of The Right Parietal Lobe PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Anorexia Nervosa is a psychiatric disorder characterized by high rates of chronicity, significant societal costs, and one of the highest mortality rates among psychiatric illnesses. Despite therapeutic advances, treatment outcomes remain poor, with high relapse rates and full recovery achieved in only 50% of cases. Recent cognitive, behavioral, and neuroimaging studies suggest that Anorexia Nervosa may involve dysfunction in a posterior parietal network responsible for multisensory integration. This network plays a pivotal role in bodily self-representation and the modulation of environment-body interactions, … |
ENRICO COLLANTONI; | 2025-08-06 |
| 125 | A Post Marketing Study to Evaluate The Safety and Efficacy of Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring A Reduction in Ethanol Use Related Papers Related Patents Related Grants Related Experts Highlight: This is the first clinical trial of Endourage OMD 1200 for persons desiring to reduce their alcohol consumption. |
THOMAS P YOUNG; | 2025-08-07 |
| 126 | The Effects of Vagus Nerve Stimulation on Pain, Muscle Stiffness, Heart Rate, And Functional Activities in Individuals With Chronic Widespread Pain – A Double Blinded Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to examine the effect of vagus nerve stimulation (VNS) on chronic, widespread pain in adults. The study will also evaluate which method of VNS-electrical ear stimulation or deep exhalation breathing-has a more significant impact on pain intensity, quality of life, and emotional well-being. The main questions it aims to answer are: Does vagus nerve stimulation reduce pain intensity in individuals with chronic, widespread pain? Which intervention-electrical ear stimulation or deep exhalation breathing-provides a greater improvement in autonomic function, emotional status, … |
MOHAMMAD(REZA) NOURBAKHSH; | 2025-07-23 |
| 127 | L-serine Supplementation in Patients With GRIN-related Neurodevelopmental Disorders: Multicentre Protocol for An Aggregated Series of Randomised, Placebo-controlled N-of-1 Trials PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical study is to find out whether L-serine dietary supplementation helps improve overall clinical functioning in children and young adults (2-30 years) with GRIN-related neurodevelopmental disorders (GRIN-NDD) caused by loss-of-function (LoF) variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D. It will also assess the safety and tolerability of L-serine. The main questions it aims to answer are: Does L-serine improve overall clinical status, measured mainly by the Clinical Global Impression-Severity (CGI-S) score? Does L-serine improve behaviour, cognition, adaptive functioning, motor skills, sleep, … |
SIMONA BALESTRINI; | 2026-01-29 |
| 128 | Effect of Different Anesthetic Drugs on Electrocorticography (ECOG), Randomized Controlled Double-blinded Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Prospective, double-blind, randomized-controlled study for pediatric cases scheduled for brain tumor excision with the aid of electrocorticography (ECOG). Intraoperative ECOG has been used in an effort to localize the site of epileptogenicity through the demonstration of Interictal Epileptiform Discharges (IED) persistence, frequency, and distribution. During ECOG, pharmaco-activation may be required in order to activate Interictal Epileptiform Abnormalities (IEAs). Frequency of IEAs will be measured for each drug. The effects of anesthetic agents on intraoperative ECOG, as we assume that fentanyl will be superior to ketamine. |
SUZAN A. ABDELRAHMAN; | 2025-09-10 |
| 129 | Evaluating Biomarkers of Temporal Interference for Temporal Lobe Epilepsy Under SEEG PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the effect of temporal interference (TI) stimulation on biomarkers in patients with temporal lobe epilepsy (TLE) under stereo-electroencephalography (SEEG), and provides theoretical basis for non-invasive TI treatment of temporal lobe epilepsy. |
XIJING HOSPITAL | 2025-07-24 |
| 130 | A Multicenter, Open-label, Long-term, Safety, Tolerability, and Efficacy Study of CB03-154 in Subjects Diagnosed With Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: CB03-154 is an investigational drug developed by Shanghai Zhimeng Biopharma Inc. for the treatment of Focal Epilepsy. |
SHANGHAI ZHIMENG BIOPHARMA | 2025-11-20 |
| 131 | Phase 1 Study of Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Epileptic spasms (ES) are a predominantly infantile seizure type observed frequently in certain genetic disorders. Ketogenic diet (high ratio of fat to carbohydrate/protein) is an established non-medication treatment for difficult to control seizures, including ES. Because ES are associated with worse developmental and cognitive outcomes if not detected or treated quickly and effectively, this trial aims to test the ketogenic diet to prevent ES in this high-risk population. This trial is a single-center pilot study of 10 infants with genetic seizure disorders to establish if the protocol of early ketogenic diet administration and ES evaluation is safe and feasible. |
HEATHER OLSON; | 2026-02-02 |
| 132 | Photobiomodulation Radiant Intervention for Stress in Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Do you have Epilepsy? Would you like to participate in a study using PhotoBioModulation (PBM)? PBM is being researched for potential benefits in resolving many stress-related brain disorders. It is a non-invasive technique that delivers light energy to cells and tissues that can promote brain stabilization and self-regulation, cell repair, reduce oxidative stress, and enhance cellular function. We ask you to participate for about 3-4 months and come to our facility for 30 minute sessions 3x a week for 15 weeks. You will receive extensive metabolic testing and an Õura ring for your participation. |
CYNTHIA KERSON; | 2026-04-03 |
| 133 | Wearable Epileptic Seizure Prediction and Alert Glasses Based on Neuromorphic Computing PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The NEXA study aims to evaluate a new wearable EEG device designed as smart glasses with dry electrodes positioned according to the 10-20 system. The device captures real-time brain signals to detect patterns that may predict seizures, helping people with epilepsy. This study will test the device’s safety, performance, and usability before seeking regulatory approval, … |
SAID AL-MAWALI; | 2025-10-07 |
| 134 | Observational Pregnancy Surveillance Program of Patients Exposed to Epidiolex/Epidyolex During Pregnancy to Assess The Risk of Pregnancy and Maternal Complications and Other Events of Interest on The Developing Fetus, Neonate, and Infant PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate pregnancy-related health outcomes in participants who are exposed to Epidiolex/Epidyolex during pregnancy and their infant up to 12 months of life. |
JAZZ PHARMACEUTICALS | 2026-03-18 |
| 135 | Bridging The Treatment Gap By Expanding Access to Care for People With Epilepsy in Kenya (BEACON) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This cluster randomized trial aims to learn about the effectiveness of task-sharing supported by an epilepsy medical records system (EMRS) (hereafter referred to as BEACON) with patient-tracking data in improving treatment adherence and retention in care in people with epilepsy in western Kenya. |
JANE VON GAUDECKER; | 2026-02-23 |
| 136 | Efficacy of Add-on Ketamine With Second-dose Midazolam for Prehospital Treatment of Epileptic Children With Status Epilepticus PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pragmatic, decentralized, pre-consented, event-driven, randomized controlled trial is to investigate the efficacy of add-on ketamine to second-dose midazolam for prehospital treatment of epileptic children with convulsive status epilepticus. |
ELSAYED ABDELKREEM; | 2025-08-05 |
| 137 | Intraoperative Multimodal Monitoring As A Means in Reducing The Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures – A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will include patients aged 50 and older scheduled for elective abdominal oncologic surgery, classified as ASA II and III due to increased anaesthetic and surgical risk. Gender will not be a stratification factor. Exclusion criteria include patient refusal, memory impairment, psychosis, known or suspected EEG abnormalities, chronic psychoactive medication use, urgent procedures, BMI below 18 kg/m² or above 35 kg/m², persistent arrhythmias, NYHA class III-IV heart failure, valvular disease, liver diseases, and anticipated surgery duration over six hours. Eligible patients must sign an informed consent form one day prior to surgery. Demographic data collected will include age, sex, … |
JASMINKA PERSEC; | 2026-01-16 |
| 138 | Acceptability and Feasibility of An Online Yoga Programme for Adults With A Functional Neurological Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a feasibility study to see if it is acceptable and helpful for people living with a functional neurological disorder to receive online group yoga sessions to improve their wellbeing |
NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST | 2025-07-22 |
| 139 | Comparative Study of Two Ultrasound-guided Percutaneous Neuromodulation Protocols on Maximal Handgrip Strength: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose of the Study: This study aims to compare the effects of two different ultrasound-guided percutaneous neuromodulation (PNM) protocols targeting the median nerve on maximal handgrip strength in healthy individuals. The study seeks to enhance scientific understanding of the clinical applications of PNM in improving neuromuscular performance and functional capacity. Benefits of the Study: Contribute to the evidence base supporting the use of PNM in physiotherapy and rehabilitation. Inform future therapeutic protocols aiming to optimize muscle strength and functional recovery. Provide participants with access to a professional evaluation of physical performance and exposure to advanced rehabilitative techniques in a safe and monitored environment. Interventions: Participants will undergo a single session of ultrasound-guided PNM to the median nerve using one of two protocols: Protocol 1 (100 Hz): 5 cycles of 5 seconds stimulation (350 µs pulse width), followed by 55 seconds rest. Protocol 2 (10 Hz): 10 cycles of 10 seconds stimulation (250 µs pulse width), followed by 10 seconds rest. In both protocols, stimulation intensity will be set to the maximum tolerable level that elicits a strong but non-painful muscular contraction. Total treatment duration will be approximately 10 minutes. Measurements: Primary Outcome: Maximal handgrip strength measured using a digital dynamometer before and after the intervention. Secondary Outcomes: Perceived pain during the intervention, assessed with the Numerical Pain Rating Scale (0-10). Sociodemographic data (age, sex, weight, height, BMI). Conclusion: This clinical trial will provide valuable insights into the comparative effectiveness of two PNM protocols for improving muscular performance. By identifying the most effective parameters for PNM application, this research may help optimize rehabilitation strategies and contribute to enhancing patients’ functional outcomes in clinical and athletic settings. |
PABLO HERRERO GALLEGO; | 2025-12-01 |
| 140 | Safety and Efficacy of AAV9/AP4B1 For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47): A Phase 1/2 Single-Center, Open-Label Study of Stereotactic Intra-cisterna Magna Administration Related Papers Related Patents Related Grants Related Experts Highlight: Safety and Efficacy of AAV9/AP4B1 For Patients with AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47): A Phase 1/2 Single-Center, Open-Label Study of Stereotactic Intra-cisterna Magna Administration. The goal of this clinical trial is to evaluate whether a gene therapy can safely treat children with SPG47, … |
DARIUS EBRAHIMI-FAKHARI; | 2025-04-28 |
| 141 | Auricular Vagal Neuromodulation Therapy in Postural Orthostatic Tachycardia Syndrome: Physiological Mechanisms and Systemic Effects – A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Autonomic nervous system imbalance causes postural tachycardia and related cardiac symptoms in Postural Orthostatic Tachycardia Syndrome (POTS). The impact of POTS is more far-reaching than postural tachycardia. Several systemic, autonomic symptoms along with neuro-cognitive dysfunction leading to poor quality of life contribute to significant disability in POTS. A combination of abnormal autonomic tone, abnormal cerebral blood flow regulation, … |
SATISH RAJ; | 2025-06-18 |
| 142 | SONATA: Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through A Web-based Music Application PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, placebo-controlled, double-blinded randomized study of self-administered auditory intervention in a naturalistic home environment. |
BRIAN FIDALI; | 2026-01-16 |
| 143 | Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy: A Prospective, Randomized, Open Blinded, End-point Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: How does magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) impact clinical prognosis in mesial temporal lobe epilepsy (mTLE)? |
KAI ZHANG; | 2026-01-21 |
| 144 | Effect of Vitamin D3 Supplementation on Brain Waves in Male Epileptic Patients With Hypovitaminosis D: A Quantitative Electroencephalogram Analysis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an experimental study (interventional self-controlled trial, pretest-post test design). The goal of this clinical trial is to evaluate the effect of vitamin D3 supplementation on quantitative EEG in male epileptic patients with hypovitaminosis D. . The main question it aims to answer is: Vitamin D3 supplementation has effect on brain waves in male epileptic patients with hypovitaminosis D. Researcher will compare the effect of Vitamin D3 supplementation on brain waves in male epileptic patients with hypovitaminosis D with their pre-intervention (baseline) condition on brain waves to assess whether there will be any improvement of brain electrical activity by quantitative electroencephalogram (QEEG). Participants will: Take Vitamin D3 orally for 8 weeks (50,000IU/week) Visit the medical university after 8 weeks for evaluation of serum 25 (OH) D level and quantitative electroencephalogram (QEEG) Must bring the empty strips of Vitamin D supplement with them during their visit |
SUMAYYA BINTE ABDUR RAZZAQUE; | 2025-07-31 |
| 145 | Economic Evaluation of Managing Epilepsy Well (MEW) Network Epilepsy Self-Management Programs PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators will conduct two-arm randomized controlled trials (RCTs) comparing effects of UPLIFT vs. enhanced usual care and PACES vs. enhanced usual care, respectively, on quality of life, depressive symptoms and seizures over 12 months in NYU patients with epilepsy. |
TANYA SPRUILL; | 2025-07-28 |
| 146 | Repurposing Mirtazapine in Rett Syndrome: A Multicentric Open Label Phase II Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Rett Syndrome (RTT) is a rare neurodevelopmental disorder caused by an MECP2 gene mutation on the X chromosome, primarily affecting females. It causes progressive motor and cognitive decline, loss of speech, repetitive hand movements, breathing issues, seizures, and sleep problems. Given RTT’s association with reduced monoamine levels, antidepressants like mirtazapine (MTZ) may help.Preclinical studies in MeCP2-mutant mice and early adult RTT trials showed that MTZ improved respiratory, motor, and neurological function, sleep, and mood, prompting this pediatric and young adult study. The MirtaRett trial is a multicenter, open-label, single-arm, phase II study enrolling 54 female RTT patients (ages 5-40), … |
ENRICO TONGIORGI; | 2026-02-24 |
| 147 | Are Developmentally At Risky Babies Environmentally Disadvantaged? PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A study conducted on infants aged between 3 and 11 months revealed a positive relationship between the home environment and developmental outcomes. Similarly, another study found that variability in motor and cognitive development could be better explained by environmental factors and parental knowledge and practices. It has also been shown that the opportunities provided in the home environment of preterm infants may be associated with motor development and sensory processing skills. In the literature, it is generally observed that studies evaluate either term infants or both preterm and term infants together. In the present study, however, … |
SEDA AYAZ TAŞ; | 2025-07-14 |
| 148 | Efficacy of Combined Ketamine and Levetiracetam As A Second-line Anti-seizure Medication for Generalized Convulsive Status Epilepticus in Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: About 40% of children with generalized convulsive status epilepticus (GCSE) are not terminated by first-line benzodiazepines (BDZs), and approximately 50% of BDZ-refractory GCSE are not controlled by second-line antiseizure medications. This study investigates the efficacy of ketamine-levetiracetam combination vs. levetiracetam alone for treating children with BDZ-refractory GCSE. |
ELSAYED ABDELKREEM; | 2025-07-03 |
| 149 | PRIMULA Preg (Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users): The AstraZeneca Pregnancy Study for Anifrolumab PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: PRIMULA Preg (Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users) is a prospective, observational cohort study designed to evaluate the association between anifrolumab exposure during pregnancy and subsequent adverse maternal, fetal, and infant outcomes. This study will fulfil an FDA post-marketing requirement. |
ASTRAZENECA | 2026-03-16 |
| 150 | Safety and Efficacy of Ventricular Irrigation for Ventriculitis: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Ventriculitis is a severe infectious disease of the central nervous system with diverse etiologies. Currently, the treatment for ventriculitis is challenging, with poor prognosis. The mortality rate of ventriculitis is generally reported to be higher than 30%, with the highest reaching over 75%. Even among survivors, over 60% suffer from a variety of neurological sequelae, including cognitive impairment, gait disturbances, paralysis, behavioral disorders, and epilepsy. Currently, treatments for ventriculitis recommended by guidelines primarily focus on the selection and administration of antibiotics, while the effects of surgical interventions have not been fully elucidated. In recent years, … |
JIYAO JIANG; | 2026-01-02 |
| 151 | A Randomized Controlled Trial of A Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized clinical trial is to be adequately powered to evaluate the effect of ketogenic metabolic therapy on the quality of life in serious mental illness, schizophrenia, bipolar disorder, major depressive disorder. |
SHEBANI SETHI; | 2025-05-16 |
| 152 | Effect of 2-phenylethanol Odor Exposure on Ictal Apneic Episode Occurrence Rate in Patients With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will investigate the potential benefits of rose scent in reducing the risk of Sudden Unexpected Death in Epilepsy (SUDEP) in patients with epilepsy. Participants will engage in their routine inpatient observational EEG monitoring for 24 hours followed by an additional 24 hours of observational EEG monitoring with continuous exposure to rose scent, during which an essential oil diffusor with rose scent will be placed in their hospital room. During these 48 total hours of the study, … |
WILLIAM P. NOBIS; | 2025-08-11 |
| 153 | Efficacy and Safety of Topical Nano Preparation of Phenytoin Plus Fractional CO2 Laser Versus Fractional CO2 Laser Alone for Treatment of Atrophic Post Acne Scars: A Randomized Split Face Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy and safety of topical phenytoin spanlastics as an adjuvant therapy in treatment of atrophic post acne scars. To compare the efficacy of topical phenytoin spanlastics combined with fractional co2 laser versus fractional co2 laser alone in treatment of atrophic post acne scars. |
SHAIMAA MOHAMED ABDALLA SULTAN; | 2025-04-24 |
| 154 | Fatigue in Cerebral Palsy: An EEG- and FDG-PET-based Study of Brain Activity and Its Correlation With Fatigue PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Persons with cerebral palsy (CP) commonly suffer from fatigue. Fatigue is an important cause of their reduced participation in work or social life. Traditionally, CP-related fatigue has been viewed as related to the person’s motor impairment. This view causes habilitation efforts to focus on muscle function. We hypothesize that the feeling of being fatigued must involve the activity of a specific, but un-identified, … |
BJØRNAR HASSEL; | 2025-12-19 |
| 155 | Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Epileptic Patients With Hypovitaminosis D PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male epileptic patients with hypovitaminosis D that weather vitamin D improves heart rate variability or not. The main questions it aims to answer are: 1. Does vitamin D improves cardiac autonomic tone in male epileptic patients? 2. Does vitamin D improves heart rate variability in male epileptic patients? It is a self control trial. Participants will: 1. undergo through baseline HRV testing 2. start to take vitamin D3 50000 IU once in a week for 8 weeks b) visit the university after 8 weeks for post interventional HRV testing . Researcher will compare the pre test and post test value of HRV testing. |
SAMIKHA SARKER; | 2025-07-25 |
| 156 | A Study on The Safety and Preliminary Efficacy of The Anti-CD38 Monoclonal Antibody Daratumumab in The Treatment of Refractory Familial Cerebral Cavernous Malformations PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebral cavernous malformation (CCM) is a common vascular abnormality of the brain, affecting 0.1%-0.5% of people. It often causes recurrent brain hemorrhages, epilepsy, and neurological impairments, with surgery being the main treatment. However, surgery carries high risks for patients with multiple lesions or lesions in critical areas, and no effective pharmacological treatment is available. CCM is linked to mutations in genes like CCM1, CCM2, CCM3, or MAP3K3, which activate the MEK5-ERK5-KLF2/4 pathway, disrupting endothelial function. Immune cell infiltration, particularly plasma cells with high CD38 expression, … |
YONG CAO; | 2025-06-18 |
| 157 | Rehearsal-Induced Memory Consolidation and Its Modulation By Sleep in People With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, … |
HOSPICES CIVILS DE LYON | 2025-07-08 |
| 158 | A Multicenter Prospective Non-Interventional Pilot Feasibility Trial for Seizure Prediction Using Wearable Electroencephalogram Among Patients With Confirmed Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a non-interventional clinical trial analyzing EEG recordings from people with epilepsy. Participants wear a comfortable EEG headband at home for several weeks. The goal is to study changes in brain activity that occur before seizures (called pre-ictal patterns) and to test whether a software algorithm can predict seizures in real-time based on these patterns. No treatments or medications are being tested. The study will help evaluate whether seizure prediction is possible using wearable EEG devices and can support the development of future tools that give patients early warnings before seizures occur. |
DUX HEALTHCARE | 2025-08-26 |
| 159 | Bevacizumab for The Treatment of Cerebral RAdiation Induced NecrosiS (BRAINS) Study: A Multicenter, Open-label, Randomized Clinical Trial to Assess The Clinical Efficacy and Cost-effectiveness of Bevacizumab Versus Corticosteroids As First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebral radiation necrosis (CRN) is a severe complication of high-dose radiation for brain metastases (BM) or glioma, which can potentially cause significant neurologic symptoms leading to serious morbidity and impaired quality of life (QoL). The first-line therapy for symptomatic CRN (sCRN) is corticosteroids, primarily dexamethasone, which often leads to complications, refractory symptoms, and interference with anti-cancer treatment. Since 2017, bevacizumab, an antibody against Vascular Endothelial Growth Factor (VEGF), … |
DIETA BRANDSMA; | 2026-01-28 |
| 160 | Evaluating Novel OPM-magnetoencephalography in Pre-surgical Mapping for Patients With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Magnetoencephalography, or MEG, is a brain-scanning method which has been available for many years. It is used in the UK and worldwide to help patients with epilepsy, who need surgery to resolve their seizures. The MEG scan can help inform the surgeon about where to operate, by mapping the abnormal brain activity caused by epilepsy. During a traditional MEG recording, patients sit very still with their head in a rigid helmet which houses many tiny sensors. This can be uncomfortable, and there are additional problems if the patient is a child, … |
CAROLINE WITTON; | 2026-01-30 |
| 161 | An Open-label, Single Arm, Dose-Escalation Clinical Study to Evaluating The Safety, Tolerability and Preliminary Efficacy of A Single Intracerebroventricular Injection of RB001 for The Treatment of SHANK3-related Phelan McDermid Syndrome Related Papers Related Patents Related Grants Related Experts Highlight: This is a first in human, open-label, dose-escalation study to evaluate the safety, tolerability, and clinical activity of a single dose of RB001 administered via intracerebroventricular (ICV) injection in pediatric with SHANK3 related Phelan-McDermid Syndrome. Clinical data will be evaluated for safety, tolerability, and preliminary efficacy of RB001 in participants with SHANK3 related PMS. |
YE WU; | 2025-07-30 |
| 162 | The Effect of Massage Based on The Human Caring Model on Self-Efficacy, Symptom Management, and Caregiver Burden in Patients With Epilepsy: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled study will be conducted with 96 epilepsy patients and their caregivers at Atatürk University Research Hospital between November 2024 and February 2026. Participants will be randomly assigned to experimental and control groups. The experimental group will receive neck massage based on Jean Watson’s Human Caring Model three times a week for eight weeks. Data will be collected using various scales to evaluate self-efficacy, symptom management, and caregiver burden before and after the intervention. |
MUŞ ALPARSLAN UNIVERSITY | 2025-10-01 |
| 163 | Trial Readiness and Endpoint Assessment in Pediatric Myotonic Dystrophy Extension PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a natural history study to improve the types of assessments and biological samples that will be used in clinical drug trials in both congenital myotonic dystrophy and childhood myotonic dystrophy. |
NICHOLAS JOHNSON; | 2025-07-30 |
| 164 | Cross-Stroke Therapy Effects With BCI and FES Stimulation: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this neurorehabilitation explorative study is to investigate how a closed-loop Brain-Computer Interface Functional Electrical Stimulation (BCI-FES) therapy, used within the intended purpose for hand rehabilitation, may impact swallowing difficulties (dysphagia) and language disorders (aphasia) in post-stroke patients. |
MICHAEL KNOFLACH; | 2025-11-26 |
| 165 | A Clinical Trial With A Self-controlled, Multicenter, Pediatric EEG Intelligent Analysis System to Assist in Diagnosis PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: A diagnostic accuracy study on Artificial intelligence EEG analysis system assisted doctors to diagnose pediatric epilepsy. |
XIAOMEI LIU; | 2025-04-09 |
| 166 | Registry and Natural History of Epilepsy-Dyskinesia Syndromes PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The Registry and Natural History of Epilepsy-Dyskinesia Syndromes is focused on gathering longitudinal clinical data as well as biological samples (blood, urine, and/or skin/tissue) from male and female patients, of all ages, who have a genetic diagnosis of epilepsy-dyskinesia syndromes. Through prospective review and molecular data analysis, the study aims to identify patterns and correlations between movement and seizure disorders, uncovering genotype-phenotype relationships. The initiative’s goals are to enhance understanding of epilepsy-dyskinesia syndromes, inform precision medicine approaches, and foster international collaboration. |
DARIUS EBRAHIMI-FAKHARI; | 2025-05-13 |
| 167 | The Effect of Inspiratory Muscle Training on Functional Gain in Cerebral Palsy: A Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates the effect of respiratory muscle training on respiratory muscle strength, respiratory parameters, trunk control, upper extremity function and dysphagia in patients with cerebral palsy aged 5-18 years. The results of the study aim to provide a clinical perspective for clinicians working with patients diagnosed with cerebral palsy between the ages of 5-18 years and to contribute to the literature. |
SADIK EMRE ÇELEBİ; | 2026-01-09 |
| 168 | The Safety and Feasibility of SeizEAR, An In-ear Device to Monitor Brain Waves From Temporal Lobes and Detect Abnormalities PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Determine the safety and feasibility of an in-ear device to measure seizures or suspected seizures compared to the standard scalp-based electroencephalogram (EEG). The study team anticipates enrolling five healthy participants through meeting announcements and a research email list serv in the Neurology Dept. Based on the appropriate positive initial test of healthy individuals, test the in-ear device on 10 participants with seizures or suspected seizures scheduled for a clinical scalp EEG test. |
HO WING CHAN; | 2025-12-23 |
| 169 | Innovative Repurposing of Trigeminal Nerve Stimulation of The Treatment of Epilepsy in Veterans PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Epilepsy is a common neurological disorder among veterans. Medications do not control seizures in 1/3rd of patients, who often require neurostimulation. However, current neurostimulation devices are invasive. Objective: The investigators propose a novel clinical trial to repurpose the FDA-approved Cefaly device, designed for migraine relief, to treat epilepsy. The Cefaly device works by non-invasive Trigeminal neurostimulation (TNS). TNS has previously shown promising preliminary results in seizure improvement. Design: The investigators will engage 24 veterans with drug-resistant epilepsy, half of whom will receive standard care, … |
HINA DAVE; | 2025-10-23 |
| 170 | A Multicenter Pilot Clinical Trial to Prevent Infantile Spasms Relapse PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: After initially successful treatment, many children with infantile spasms unfortunately have a relapse, and relapse is linked to poor long-term outcomes such as autism and other forms of epilepsy. The aim of this study is to determine if treatment with low-dose prednisolone is safe, well tolerated, and effective in reducing the risk of relapse. |
SHAUN HUSSAIN; | 2025-05-08 |
| 171 | Impact of RTMS Combined With Neurorehabilitation on Lower Extremity Motor Function and Spasticity in Children With Spastic Diplegic Cerebral Palsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebral palsy (CP) is widely recognized as the most prevalent cause of lifelong physical disability emerging in childhood across most global populations. While international data typically reports a prevalence ranging from 1.5 to 2.5 per 1,000 live births, in our specific national context, this rate is notably higher, reaching 4.4 per 1,000. CP is defined as a heterogeneous group of permanent disorders that fundamentally disrupt the development of movement and posture. These disruptions lead to significant activity limitations and are attributed to non-progressive disturbances occurring in the developing fetal or infant brain. Beyond primary motor impairments, … |
ÖZLEM KAYNAR ŞIŞMAN; | 2026-03-23 |
| 172 | Characterization and Analysis of Evoked Cortical Responses in Participants With Medication-intractable Epilepsy Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this project is to study how the brain reacts to a small electrical signal. Researchers will be using a novel combination of recording electrodes. The researchers will measure the brain response from these electrodes. |
MATTHEW S WILLSEY; | 2025-06-11 |
| 173 | Genesis: Clinical Trial of Better Speech’s Artificial Intelligence Helper for Speech Therapy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to evaluate the effectiveness of a hybrid Artificial Intelligence-assisted speech therapy model, which combines the use of an AI speech therapist (Jessica) with traditional speech therapy sessions led by a Speech-Language Pathologist (SLP). This study aims to determine whether the hybrid model improves articulation in children more effectively than traditional SLP-only therapy. Over the course of 8 weeks, participants will receive weekly therapy sessions, … |
SYRACUSE UNIVERSITY | 2025-07-11 |
| 174 | The Effect of Memory-Based Exercise and Planned Training Applied to Epilepsy Patients on Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Epilepsy; It is a chronic, neurological disease that can occur regardless of social class, race and age. Every year, approximately 5 million people worldwide are diagnosed with epilepsy and 50 million people are affected by this disease, constituting a significant part of the disease burden in the world. When we look at the rate of patients in the population who actively experience symptoms of the disease and need treatment, this rate is approximately 4 to 10 people per 1000 people. According to estimates, … |
AHMET ŞİMŞEK; | 2025-05-02 |
| 175 | Effect of Peripheral Magnetic Stimulation in Patients With Chronic Lower Back Pain – Controlled, Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to analyze the effect of Repeated Peripheral Magnetic Stimulation (rPMS) in patients with chronic low back pain. This is a controlled, randomized, multicenter clinical trial (Brazil x Portugal). The sample will consist of individuals with chronic low back pain with a score between 40 and 80 on the Oswestry scale, who will be randomly divided into 2 groups: control (CG) and intervention (IG). The instruments used for evaluation will be: visual analog pain scale (VAS), brief pain inventory (BPI), McGill questionnaire, Roland Morris scale and WHOQOL-BREF. Both groups will use the EMP device, … |
INÊS GOMES; | 2025-12-04 |
| 176 | Ferumoxytol Enhanced Hippocampal Vascular Imaging in Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, … |
DONALD GROSS; | 2025-05-06 |
| 177 | Prevalence and Pattern of Comorbid Headache in Pediatric Epilepsy Patients Attending Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to determine the prevalence and characteristics of headaches in children with epilepsy, aged 5-18 years. Approximately 60 children will participate at Assiut University Children’s Hospital. The research will involve medical history collection, physical and neurological exams, EEG review, and blood tests. The study seeks to improve understanding of the relationship between epilepsy and headaches in children, potentially leading to better treatment strategies. Participation is voluntary, and the risks are minimal. |
SOMIA RASHEED ABDELRASOUL; | 2025-03-10 |
| 178 | Epilepsy Cycles Longitudinal Monitoring to Inform Personalized Seizure-risk Estimation, A Double-blinded Study of Seizure Forecasting and Randomized Information Withdrawal in Adults With Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The occurrence of seizures in epilepsy is not entirely random. Temporal patterns that organize the occurrence of seizures over weeks and months were previously unraveled using intracranial EEG System (IEEG) that monitors epileptic brain activity chronically. Seizures typically recur with patient-specific periodicity and are preceded by increases of epileptic brain activity over days. Here, the investigators developed new methods to forecast seizure likelihoods at a 24-h horizon. In this trial, participants will be provided with daily estimates about their upcoming risk of seizures. As a primary outcome, … |
INSEL GRUPPE AG UNIVERSITY HOSPITAL BERN | 2025-05-01 |
| 179 | An Investigator Initiated and Conducted, Prospective, Multicentre, Randomised Outcome-blinded Study of Pre-hospital Initiated Levetiracetam and Headposition in Patients With Presumed Acute Stroke PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This is an investigator initiated and conducted, multicentre, ambulance-delivered, prospective, randomised, open-label, blinded outcome (PROBE) study. EAST aims to evaluate the effects of pre-hospital levetiracetam and different head positions initiated in ambulance settings on the functional outcome of participants assessed at 90 days. |
GANG LI; | 2025-05-22 |
| 180 | CAMSAN: Cognitive Augmentation Via Multimodal Sensing and Auricular Neurostimulation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to extend this period of optimal cognitive performance by applying neurostimulation to buffer health volunteers against the effects of increased levels of stress, distraction, and cybersickness. The main questions it aims to answer are: * Can we use OpenBCI’s head-mounted Galea biosensor + eXtended Reality (XR) platform to measure participants’ cognitive state in relation to stress, attention and cybersickness? * How does applying external neurostimulation via Spark Biomedical’s Sparrow Link transcutaneous auricular neurostimulation (tAN) system enhance cognitive performance with a closed-loop interface that automatically applies neurostimulation as a function of physiologically determined stress, … |
MUSA MAHMOOD; | 2025-06-12 |
| 181 | Study on The Effectiveness and Safety of Temporal Interference Stimulation in Treating Patients With Severe Consciousness Disorders PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Investigating the efficacy and safety of temporal interference stimulation for patients with disorders of consciousness. |
XUEHAI WU; | 2025-12-16 |
| 182 | Arterial Spin Label Assessment of Cerebral Blood Flow in Anesthetized Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Children undergoing magnetic resonance imaging (MRI) of the brain often need to be sedated to complete the examination, as it is difficult to remain still for a long period, which is required to obtain usable images. During sedation, most patients typically experience a drop in blood pressure, including children. Maintaining an adequate blood pressure under anesthesia is important, as blood pressure is routinely used as a measure to ensure sufficient blood circulation to the body’s organs, including the brain. Ensuring adequate blood flow to the brain is one of the cornerstones of all anesthesia, including in children. Therefore, … |
JACOB KARLSSON; | 2025-03-25 |
| 183 | In Vitro Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Cannabis, in addition to its psychotropic properties, could have anti-inflammatory and immunomodulatory effects. Phytocannabinoids (pCBs) are a group of molecules naturally secreted by the cannabis plant. The major pCBs are cannabidiol (CBD) and Δ9-tetrahydrocannabinol Δ9 (THC). Only THC has psychotropic effects, which CBD does not have. Alongside these two main components, there is a wide variety of other molecules, such as other pCBs and terpenes which could increase the effects on immune system through synergistic interactions between these different compounds (entourage effect).In vivo, pCBs essentially interfere with the endocannabinoid system, acting on many ubiquitous receptors, … |
CARINE PR SALLIOT; | 2025-12-30 |
| 184 | Retraining and Control Therapy (ReACT): Sense of Control and Catastrophic Symptom Expectations As Targets of A Cognitive Behavioral Treatment for Adult Functional Seizures (FS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of adult psychogenic non-epileptic seizures (PNES, episodes resembling epileptic seizures but with no correlated epileptiform activity). 19 years and older participants diagnosed with PNES who are treated at UAB FND clinic will engage in twelve sessions of ReACT. Participants will be randomly assigned to one of three conditions: no wait, 3-month waiting period, … |
AARON FOBIAN; | 2025-06-06 |
| 185 | CorEvitas Inflammatory Bowel Disease Pregnancy Registry (IBD-PR) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Data collected through the registry may be used to address a range of research questions and objectives, including but not limited to the following: Research question: Is there an increased risk of adverse maternal, fetal, or infant outcomes among individuals who are exposed to Inflammatory Bowel Disease (IBD) treatments during pregnancy? The primary objective of the registry is to estimate the prevalence of major congenital malformations among pregnant individuals with IBD who are exposed to an IBD pharmacotherapy during pregnancy. The secondary objectives of the registry are: To estimate the prevalence of other maternal, fetal, … |
RONNA L CHAN; | 2025-04-04 |
| 186 | ASSOCIATION BETWEEN TEMPOROMANDIBULAR DISORDERS AND SLEEP DISORDERS PF:3 Related Papers Related Patents Related Grants Related Experts Abstract: Temporomandibular disorders (TMD) are complex conditions, which can have a significant impact on patients’ health and quality of life. Furthermore, they are unclearly associated … |
LUIGI FERINI STRAMBI; | 2025-05-16 |
| 187 | The Research on The Role of Human Chorionic Gonadotropin (HCG) Activation in Vivo on The Dormant Follicles in Patients With Premature Ovarian Insufficiency (POI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project aims to activate dormant follicles in patients with premature ovarian insufficiency by injecting human chorionic gonadotropin (hCG) to explore the feasibility of a treatment plan that stimulates the growth of dormant follicles, not visible to the naked eye, to antral follicles visible under ultrasound, without visible follicle growth. The project also seeks to enable patients to conceive offspring carrying their own genetic material through in vitro fertilization (IVF) technology. |
XIAO CHEN; | 2025-03-12 |
| 188 | Clinical Research Protocol on Accelerating Motor Rehabilitation in Postoperative Motor-Deficient Glioma Patients Using NrTMS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Project Name Clinical Research Protocol on Accelerating Motor Rehabilitation in Postoperative Motor-Deficient Glioma Patients Using nrTMS Research Objectives 1. Investigate the relationship between motor rehabilitation and changes in motor functional networks after nrTMS therapy, and confirm the contralateral hand motor area as an effective rehabilitation target. 2. Validate the efficacy of high-frequency nrTMS stimulation in rehabilitating motor deficits in glioma patients. Study Design \> A randomized, double-blind, … |
BEIJING NEUROSURGICAL INSTITUTE | 2025-12-16 |
| 189 | Long Term Efficacy and Safety of Transcranial Magnetic Stimulation Targeting Cerebellum to Treat Drug-resistant Epilepsy During Enhanced and Maintenance Phase PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to observe the long term efficacy and safety of cerebellar continuous θ burst stimulation (cTBS) for drug-resistant Epilepsy during enhanced and maintenance phase，in order to provide a new treatment for long-term control of drug-resistant epilepsy and improve the quality of life of those patients. A total of 100 patients with DRE will undergo cTBS treatment by precise navigation to bilateral cerebellar dentate nuclei. The frequency and clinical feature of seizures, scalp EEG，clinical score, MOCA，MMSE，and QOLIE-31 were ssessed at baseline, after 2 weeks of enhanced phase，8 weeks of consolidate phase, and 8 weeks of maintenance phase. |
XIJING HOSPITAL | 2025-04-03 |
| 190 | The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background and Aim: Carbon monoxide (CO) poisoning is a significant public health issue that can cause delayed neuropsychological sequelae (DNS). DNS mechanisms involve oxidative stress, inflammation, and immune injury. Although hyperbaric oxygen therapy is widely used, … |
CHINA MEDICAL UNIVERSITY HOSPITAL | 2025-03-26 |
| 191 | Treatment With Auricular Vagus Nerve Stimulation in Rheumatoid Arthritis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose and aim The overall aim is to investigate efficacy and safety of a newly developed non-invasive auricular investigational device that electrically stimulates the auricular branch of the vagus nerve to activate the cholinergic anti-inflammatory mechanism to treat rheumatoid arthritis patients not responding to standard therapy. The mode of treatment is termed transcutaneous auricular vagus nerve stimulation (taVNS). Specifically, the investigators will address the following research questions: The investigation is a multicenter, placebo-controlled, randomized, double-blinded, superiority, clinical study to evaluate the safety and efficacy of a novel transcutaneous auricular vagus nerve stimulator system, termed TRAVAGUS, … |
MELIHA C KAPETANOVIC C KAPETANOVIC; | 2025-09-10 |
| 192 | Cartography of Social Cognition Network and Their Alterations in Patients with Epilepsy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Social cognition, which refers to the ability to interpret social information and behave accordingly in a social environment, is crucial in everyday life. But this ability has been shown to be altered in patients with epilepsy, especially in medial temporal lobe epilepsy, which leads to a deterioration in the patient’s quality of life. However, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-03-21 |
| 193 | Child Bipolar Network Ketogenic Diet Approach to Bipolar Disorder in Adolescents PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The present study is an open trial of ketogenic diets for adolescents and young adults (ages 12-21 yrs) in the depressive or mixed phases of bipolar disorder (BD). The investigators aim to determine whether combining standard of care pharmacological treatment for bipolar spectrum disorders with a 16-week ketogenic diet is well-tolerated and associated with improvements in depression, inflammatory and metabolic indicators, and executive functioning over the study period. The experimental treatment in this study is a 16-week full ketogenic diet. Four study sites (UCLA, U Cincinnati, … |
DAVID J. MIKLOWITZ; | 2025-04-23 |
| 194 | Effects of Treadmill Training With and Without Compression Stockings on Toe Walking and Balance in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Autism Spectrum Disorder (ASD) affects around 1.7% of US children, with co-occurring conditions like ADHD, anxiety, and epilepsy complicating daily functioning. Early intervention strategies, such as sensory-based therapies and physical exercises like treadmill training, are used to improve motor skills and overall functioning in children with ASD. A randomized controlled trial is being conducted to evaluate the impact of treadmill interventions on children with toe-walking behaviors. Participants will be assigned to either Group A or Group B, … |
QUTBIA ABAQ JAVED CHEEMA; | 2025-03-25 |
| 195 | Study of Sexual Quality of Life in Women With Breast Cancer Who Had Multidisciplinary Management With Photobiomodulation for Genitourinary Syndrome of The Menopause PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The treatment of breast cancer as well as the disease are responsible for genito-urinary symptoms that can persist over time and impair quality of life. Given the improved prognosis of breast cancer, more and more patients are confronted with specific post-cancer issues, and the care has become a major health challenge. Sexual health is a crucial component of well-being and overall quality of life. Vaginal dryness and dyspareunia are symptoms frequently found in patients treated for breast cancer, with chemotherapy and hormone therapy as risk factors. However, … |
ANGÉLIQUE BOBRIE; | 2025-11-18 |
| 196 | Randomized Phase 2 Study of Valproic Acid Combined With Rechallenge Anti-EGFR Based Regimen Regimens in Pretreated Patients With RAS/BRAF Wild-type Metastatic Colorectal Cancer – VICTORIA Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators hypothesize that the epigenetic agent valproic acid improve the activity of anti-EGFR agents, prevent and revert the emergence of EGFR resistance, in a rechallenge setting. Correlative mechanistic studies on tissue and blood samples, liquid biopsies, could identify potential biomarkers of efficacy and help understanding the evolutionary dynamics of tumors in response to therapy thus optimizing the treatment approach with a personalized anti- EGFR treatment strategy. |
MICHELE ORDITURA; | 2025-12-17 |
| 197 | A Single-center, Double-blind, Placebo-controlled Crossover Study Evaluating NPT 2042 Versus Placebo in Subjects Aged 16-75 Years With Genetic Generalized Epilepsy (GGE) and Absence Seizures PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will compare the effect of NPT 2042 and placebo in subjects with GGE on the frequency and duration of electroencephalographic absence seizures, separated by a 14-day washout period. The study will be a single-center, double-blind, crossover study with subjects receiving either NPT 2042 80 mg BID orally or matching placebo BID in each of two treatment periods. |
VICTOR BITON; | 2025-10-15 |
| 198 | The Effect of Epilepsy Management at School Mobile Health Application on Epilepsy Knowledge, Attitudes, and Self-Management of Teachers of Children With Intellectual Disability: A Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to determine the effects of the training given to the teachers of children with intellectual disabilities with the Epilepsy Management at School Mobile Health Application and the Digital Epilepsy Education Guide on teachers’ epilepsy knowledge, attitudes, and self management levels. This study was planned in a pretest, posttest design, follow-up, randomized controlled study. The sample of the study will consist of 90 teachers. Intervention-1 (Epilepsy Management at School Mobile Health Application, n=30), intervention-2 (Digital Epilepsy Education Guide, n=30) and control group (group without any intervention, … |
ZAHIDE İYİ ALTINIŞIK; | 2025-05-08 |
| 199 | Study of Epilepsy and Seizure in Elderly Patients in Sohag University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study underscores the importance of studying the etiology, clinical characteristics, and types of epilepsy in the elderly to improve diagnosis and management in our community. |
MOSTAFA ELSAYED ABDELWAHAB; | 2025-06-18 |
| 200 | High-field MR Imaging in Migraine, Visual Snow and Epilepsy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this project, the aim is to recruit patients with drug resistant epilepsy and those suffering from migraine. Interestingly, patients suffering from epilepsy are also more often reporting to suffer from migraine. The pathobiology is understudied, … |
PATRICK FREUND; | 2025-10-08 |