Clinical Digest: Recent Clinical Trials on Gonorrhea (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Gonorrhea. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Gonorrhea (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Combatting HIV Or Other STIs Early (CHOOSE): An Integrated Strategy of Pre-Exposure Prophylaxis (PrEP) Mobile Health (mHealth) Support and Doxycycline Post-Exposure Prophylaxis (DoxyPEP) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The overarching goal of this project is to optimize the PrEP Choice integrated mHealth package and assess the efficacy and cost of PrEP Choice on PrEP initiation and adherence among young people. It is hypothesized that PrEP Choice will improve HIV PrEP uptake and adherence among young people and will be cost-effective to deliver to young people in the United States (U.S.). This study will also assess the uptake, adherence, and acceptability of DoxyPEP among young people. |
ALBERT LIU; | 2026-04-03 |
| 2 | A Multi-Center Assessment of An Intervention to Provide Long-Acting Cabotegravir Injectable Pre-Exposure Prophylaxis to People Who Inject Drugs PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to determine the feasibility and impact of delivering long-acting injectable cabotegravir HIV pre-exposure prophylaxis and suite of support services to adults who inject non-prescription drugs who are risk for HIV through known sexual risk. |
SUZANNE MCCLUSKEY; | 2026-03-19 |
| 3 | Clinical and Implementation Outcomes of A Point of Care Sexually Transmitted Infection Testing Strategy to Improve HIV Prevention Service Delivery in Adolescents PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed research hypothesizes that point-of-care testing (POCT) for sexually transmitted infections (STIs) gonorrhea and chlamydia will be a feasible, acceptable, and appropriate implementation strategy for improving HIV testing and Pre-exposure prophylaxis (PrEP) delivery in youth, by increasing opportunities for clinician-patient counseling, decreasing loss to follow up, and allowing for same-day HIV prevention service provision. This hypothesis will be tested in a pragmatic non-randomized trial comparing clinical (HIV testing and PrEP counseling and prescription) and implementation (feasibility, acceptability, and appropriateness) outcomes between adolescents receiving POCT compared to laboratory-based testing at three clinics within a large pediatric health system. |
SARAH WOOD; | 2025-11-14 |
| 4 | Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Among Adolescent and Young Adult Females in The United States PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also evaluating acceptability and antimicrobial resistance in order to inform public health policy. |
CHERIE BLAIRE; | 2026-01-02 |
| 5 | Quasi-Randomized Controlled Trial of Acceptance and Commitment Therapy for Chemsex Related Papers Related Patents Related Grants Related Experts Highlight: Quasi-randomized control trial of acceptance and commitment therapy (ACT) for chemsex. |
NICHOLAS C. BORGOGNA; | 2025-12-15 |
| 6 | Doxi-Rio: Pilot Implementation of Post-exposure Prophylaxis for Sexually Transmitted Infections With Doxycycline in Rio De Janeiro, Brazil PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if doxycycline post-exposure prophylaxis (doxy-PEP) can help prevent bacterial sexually transmitted infections (STIs) among sexual and gender minorities in Rio de Janeiro, Brazil, including men who have sex with men, transgender women, and travestis who are living with HIV or using HIV pre-exposure prophylaxis (PrEP). Bacterial STIs such as syphilis, gonorrhea, and chlamydia remain common in these populations, even with existing prevention strategies. This study aims to answer the following questions: whether doxy-PEP can reduce the number of new STIs, whether it is safe and well tolerated, … |
BEATRIZ GRINSZTEJN; | 2026-03-30 |
| 7 | The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing Sexually Transmitted Diseases (Gonorrhea, Chlamydia, Syphilis) Among Men Who Have Sex With Men in Bangkok, Thailand PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this research is to evaluate the efficacy and safety of doxycycline in MSM for preventing sexually transmitted infections (gonorrhea, chlamydia, and syphilis) in Thailand Participation in this study will last approximately 12 weeks and will include 2-3 clinic visits, along with 10-11 follow-up phone contacts over a period of 11 weeks. |
ROSSAPHORN KITTIYAOWAMARN; | 2026-02-09 |
| 8 | Implementation and Delivery of Lenacapavir for PrEP in A Community Pharmacy Setting PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label, single center study to evaluate implementation of a pharmacist-managed delivery of L4P in a community pharmacy setting and the impact of twice-yearly vs. quarterly PrEP visits on STI rates. |
KELLEY ROSS & ASSOCIATES | 2026-04-02 |
| 9 | The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Globally, new HIV infections are concentrated in eastern and southern Africa where the infections are largely acquired by women outside of known key populations. Identifying African women at high risk for HIV acquisition and successfully engaging them in HIV prevention services, particularly pre-exposure prophylaxis (PrEP) programs, is an urgent global health priority. The U.S. President’s Emergency Plan for AIDS Relief program in Africa typically relies on self-reported risk screening tools (SRST) to target HIV testing and refer individuals for PrEP. However, these tools have low to moderate sensitivity, … |
MARY KATHRYN GRABOWSKI; | 2025-09-15 |
| 10 | Massachusetts HIV and Justice Involved Populations Research Network PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This pilot feasibility study represents part 3 of a larger R61 study, where the investigators will follow a cohort about their experiences with human immunodeficiency virus (HIV) testing. This project aims to assess the effectiveness of an intervention at two jail sites in the Boston area: South Bay House of Corrections and Nashua Street Jail implemented in January of 2025 that is aimed at improving HIV testing practices and HIV treatment in those carceral facilities. This implementation was developed independently of the investigators’ study activities. The jails worked to develop changes in their electronic health record to offer HIV testing at various points in their intake and physical exam process. HIV care was not well-integrated with the jails’ existing intake and healthcare administration systems and medications for opioid use disorder (MOUD) program. The investigators will evaluate the intervention the jails developed to address these issues. The outcomes of interest are more implementation than effectiveness outcomes. The primary goal of this study is to identify existing barriers in the carceral healthcare setting that prevent the improvement of HIV testing and treatment. |
ALYSSE WURCEL; | 2025-07-30 |
| 11 | Impact of The COVID-19 Pandemic on Syphilis: Epidemiological Changes and Interaction With HIV PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Sexually transmitted infections (STIs) represent a significant challenge to global public health. Although many of these infections are treatable, failure to diagnose and delayed treatment can lead to serious complications, including infertility, chronic inflammatory diseases, and an increased risk of HIV transmission. The COVID-19 pandemic has had a significant impact on healthcare management, the economy, and citizens’ lifestyles. The first lockdown in the spring of 2020 affected the entire country, while in the following months, government measures were differentiated on a regional basis, with varying restrictions on activities and mobility. Physical distancing, the use of personal protective equipment, … |
AZIENDA OSPEDALIERA SS ANTONIO E BIAGIO E CESARE ARRIGO DI ALESSANDRIA | 2025-09-02 |
| 12 | STI Self-swab Testing At The Time of Telemed Medication Abortion Provision PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this interventional study is to provide more access to STI testing for patients who seek abortion care through telemedicine, particularly for those whose access to STI testing is otherwise limited. The main questions it aims to answer are: What is the acceptability, feasibility, … |
OLIVIA MANAYAN; | 2025-06-26 |
| 13 | Establishing Baseline Sysmex UF-5000 Flow Cytometer Results in Healthy Men PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Acute urethritis (inflammation of the male urethra) affects millions of men in the United States each year. Effective management of STIs is complicated by asymptomatic infections, as men often delay seeking care until symptoms become severe. Yet, even men without symptoms can show measurable evidence of urethritis. Therefore, a cheap, simple, and non-invasive point-of-care (POC) test, providing results within 30 minutes, could significantly enhance STI management by facilitating early diagnosis and treatment. A new diagnostic method, urine flow cytometry, … |
STEPHEN J. JORDAN; | 2025-07-18 |
| 14 | Clinical Outcomes and Safety of An Intravaginal Negative Pressure Medical Device in The Treatment of Genitourinary Syndrome of Menopause (GSM): A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This pilot study aims to evaluate the safety and effectiveness of the VITA AV Clinical System over a period of up to three months after the last treatment, compared to a sham device. The study focuses on improving vaginal signs and symptoms of Genitourinary Syndrome of Menopause (GSM) in post-menopausal women who experience moderate to severe pain during intercourse (dyspareunia). Long-term follow-up visits will assess the ongoing effectiveness and durability of the treatment, while also collecting safety data. |
NANCY PHILIPS; | 2025-11-03 |
| 15 | Optimizing Mobile Interventions to Overcome Stigma and Promote HIV Prevention PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This project will develop a multi-component, technology-delivered intervention designed to reduce HIV and intersectional stigma and improve the use of HIV pre-exposure prophylaxis (PrEP) among HIV-negative Thai vulnerable emerging adults (18-29 years). |
BO WANG; | 2025-09-08 |
| 16 | Cranberry, Hibiscus, and Vitamin C Extracts Versus Placebo in Latency of Premature Rupture of Membranes. Randomized Double-blind Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this clinical trial is to evaluate the effect of cranberry, hibiscus and vitamin C extracts supplementation on the duration of the latency of premature rupture of membranes in pregnant women between 24 and 34 weeks with PROM compared to placebo administration through a randomized double-blind clinical trial, which will be carried out from July to December 2024 in the pathological hospitalization ward of the Hospital Materno Infantil, with a sample of 84 pregnant women, divided into 2 equal groups (A and B), a control group and a placebo group, … |
RICARDO A GUTIERREZ RAMIREZ; | 2025-09-08 |
| 17 | Screen to Prevent: Using Digital Health to Improve HIV Screening and Prevention for Adolescents in The Emergency Department PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this interrupted time series quasi-experimental design study is to implement universal opt- out HIV testing and linkage to HIV preventive care in 15-21 year old adolescents visiting the pediatric emergency department (ED). The main question\[s\] it aims to answer are: 1. What is the uptake, reach and effectiveness of universally offered, opt-out HIV screening across pediatric EDs after implementing an adapted version of a tablet-based screening process? 2. What is the successful linkage to comprehensive HIV pre-exposure prophylaxis (PrEP) care using a novel, … |
JENNIFER L REED; | 2025-02-20 |
| 18 | Enhancing HIV Prevention and Reducing Alcohol Use Among People Receiving STI Care in Lilongwe, Malawi: A Pilot Implementation Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose: To evaluate short-term efficacy and implementation of Treat4All, an alcohol reduction evidence-based intervention, for decreasing heavy drinking and optimizing HIV outcomes (viral suppression among People with HIV (PWH); … |
ANGELA PARCESEPE; | 2026-01-30 |
| 19 | Assessing The Use of MY-RIDE, A Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine whether Motivating Youth to Reduce Infections, Disconnections, and Emotion dysregulation (MY-RIDE) decreases substance use , to determine whether MY-RIDE increases human immunodeficiency virus (HIV) prevention strategies and to evaluate MY-RIDE effects on willingness to take Pre-Exposure Prophylaxis (PrEP), stress, substance use urge, and use of mental health and substance use services when compared to attention control youth |
DIANE SANTA MARIA; | 2025-05-23 |
| 20 | ED2PrEP – Patient Focused, Low-burden Strategies for PrEP Uptake Among Emergency Departments Patients: A Two-arm Hybrid Implementation-effectiveness Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Severe inequities in HIV pre-exposure prophylaxis (PrEP) access and use in communities hardest hit by the HIV epidemic persist, further exacerbating ongoing racial/ethnic and socioeconomic disparities in HIV incidence. In these same communities, many patients at risk for HIV seek care for sexually transmitted infections (STIs) in Emergency Departments (EDs), but the structure of traditional ED care is poorly suited to address HIV prevention or provide PrEP. To advance the Prevent objective of the Ending the HIV Epidemic (EHE) initiative, … |
URIEL FELSEN; | 2026-03-31 |
| 21 | The Prevalence of Chlamydia Trachomatis and Neisseria Gonorrhoeae in Patients Suspected of Hemorrhagic Proctosigmoiditis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background Chlamydia trachomatis and Neisseria gonorrhoeae can cause infectious proctitis, which macroscopically cannot be distinguished from haemorrhagic proctosigmoiditis (HP) caused by inflammatory bowel disease. In Denmark, general practitioners are advised to consider whether patients presenting with proctitis symptoms might have a sexually transmitted infection (STI). However, there is no requirement for STI testing before referring the patient to a specialised department. At specialised departments, it is not standard practice to systematically inquire about sexual risk behaviour or to test for Chlamydia and Gonorrhoea. As a result, … |
ANDERS K DIGE; | 2025-11-18 |
| 22 | A Phase 3 Randomized, Observer-Blind, Placebo-Controlled Study to Assess Efficacy of Meningococcal Group B (rMenB+OMV NZ (Bexsero)) in Preventing Gonococcal Infection Among South African Cis-Gender Women PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This proposed 2-arm randomized evaluation of two doses of 4CMenB vaccine versus placebo at Enrollment and Month 2 is designed as a proof-of-concept study to inform potential use for dual meningococcal B and gonococcal prevention, and to inform Neisseria gonorrheae vaccine development. |
CONNIE CELUM; | 2025-07-10 |
| 23 | Testosterone Effects on Sexual Health in Transgender Men: Feasibility Study of An Oral Intervention PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Transgender men (TGM) have a high incidence of sexually transmitted infected (STIs), including HIV, HPV and bacterial N. gonorrhea and C. trachomatis. In addition, TGM who start testosterone therapy (TT) experience significant vaginal morbidity that causes vaginal dryness and pain, due to the estrogen-inhibiting effects of TT on vaginal epithelium. Vaginal dysbiosis is a known contributor of increased STI risk and vaginal symptoms. In a future study, the investigators are planning a randomized trial of a 6-month oral Lactobacillus probiotics intervention in TGM on TT at the Callen-Lorde Community Health Center (CLCHC), … |
RUPAK SHIVAKOTI; | 2025-05-09 |
| 24 | Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior (TRB). Participants are randomized to one of two conditions: couples MI or standard couples HIV testing and counseling (CHTC). |
TYREL STARKS; | 2025-06-13 |
| 25 | Adapting MHealth Interventions to Improve Self-management of HIV and Substance Use Among Emerging Adults in Zambia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This project will develop and implement a multi-component intervention using mobile health technology to improve HIV self-management and reduce substance use. Specifically, the investigators will adapt Healthy Choices (HC) to develop mobile HC (mHC) and develop Motivational text messaging (MTM) for Zambian emerging adults living with HIV. |
BO WANG; | 2025-12-18 |
| 26 | Zenyth: Feasibility and Acceptability of An Motivational Interviewing (MI)-Based Telehealth Intervention for Bacterial Sexually Transmitted Infection (STI) Screening PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In the United States (US), gay and bisexual men living with human immunodeficiency virus (HIV) bear a heavy burden of bacterial sexually transmitted infections (STIs) such as gonorrhea, chlamydia, and syphilis. It is important to diagnose and treat STIs in a timely manner to prevent health complications and reduce transmissions. The purpose of this study is to understand whether gay and bisexual men living with HIV are willing to collect and return specimens for bacterial STI testing when combined with live audio/video (AV) conferencing support. |
AKSHAY SHARMA; | 2025-07-01 |
| 27 | Comprehensive Assessment in A Longitudinal Study on Young Men Who Have Sex With Men Attracting to ChemseX-2 PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: CLYMAX is a two-phase observational study that assess multiple aspects of chemsex and young men who have sex with men (YMSM). Phase I of the study (CLYMAX,IRB No. 0695/65) was a cross-sectional descriptive study using a mixed methods data collection (focusing on qualitative data collection) assessing multiple aspects of chemsex, including the patterns of chemsex use and the perspectives on factors influencing chemsex initiation/discontinuation, effects on physical health, mental health and social outcomes, and the necessary services for a comprehensive chemsex clinic among YMSM; and the acceptability and feasibility of developing a comprehensive chemsex clinic from the perspective of YMSM, … |
INSTITUTE OF HIV RESEARCH AND INNOVATION FOUNDATION THAILAND | 2026-04-02 |
| 28 | Time to Clearance of Chlamydia Trachomatis and Neisseria Gonorrhoeae RNA After Treatment: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the negativation time of chlamydial and gonococcal PCRs after treatment for urogenital, oropharyngeal and anal infections. |
UNIVERSITY HOSPITAL STRASBOURG FRANCE | 2025-11-01 |
| 29 | Pharmacy-based Testing and Treatment for Gonorrhea and Chlamydia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are the first and second most commonly reported sexually transmitted infections (STI) in Canada, respectively, and rates are increasing. While CT and NG can cause a variety of non-specific symptoms, an estimated 77% of CT and 45% of NG cases are asymptomatic. Consequently, many individuals remain undiagnosed, or have delayed diagnosis and consequently miss effective and well-tolerated therapies and may transmit the infection(s) to sexual partners. Untreated CT infection may result in serious sequelae. Also, … |
TASHA RAMSEY; | 2025-09-01 |
| 30 | CAMELLIA Cohort: A Longitudinal Study to Understand Sexual Health and Prevention Among Women in Alabama PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Pre-exposure prophylaxis (PrEP) is an important biomedical human immunodeficiency virus (HIV) prevention tool and may particularly benefit black, cis and trans-gender women, who are at an increased risk for HIV and Sexually Transmitted Infections (STIs). The purpose of this study is to use a population-based approach to create a cohort of cis and trans-gender women at risk for future HIV acquisition to better understand the factors associated with the risk of STIs and HIV diagnosis and predictors of PrEP use. |
LYNN T. MATTHEWS; | 2025-09-10 |
| 31 | Comparative Effectiveness of Individual Versus Group-level Interventions to Reduce HIV Risk Among African Immigrant Women PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The HIV diagnosis rate among African-born Black women is the highest of all Black individuals living in the US. Correct and consistent use of condoms and use of pre-exposure prophylaxis (PrEP) are two effective means of decreasing HIV risk among women, but they remain suboptimal among Black women. The specific aims of this study are: 1. To culturally adapt two widely utilized, evidence-based HIV prevention interventions originally designed for US born Black women (Sister-to-Sister (S2S) and Sisters Informing Sisters about Topics on AIDS (SISTA)) for use by African-born women. To ensure the interventions resonated with African culture, … |
BISOLA O. OJIKUTU; | 2026-02-27 |
| 32 | Community Intervention to Eliminate HCV Among People Who Use Drugs. Implementation Study in The Cities of Paris, Marseille, Lyon and Fort-de-France, France PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this interventional study is twofold with the evaluation of the feasibility and potential usefulness of an implementation strategy, and the efficiency of a community-based model of mass screening and immediate treatment of hepatitis C among People Who Use Drugs (PWUD) in three major cities in mainland France (Paris, Lyon and Marseille) and in one overseas city (Fort-de-France). The investigators will also describe the psychological and infectious comorbidities of drug users, determine the stages of the HCV (Hepatitis C Virus), HBV (Hepatitis B Virus), HIV (Human Immunodeficiency Virus) care cascade, … |
HÉLÈNE DONNADIEU; | 2025-09-08 |
| 33 | Feasibility and Acceptability of An Electronic Clinical Decision Support Tool for Adolescent Sexual and Reproductive Health Services PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Many studies show early detection of sexual activity in adolescents can improve their health management and that primary care pediatricians would benefit from supports to address adolescent health, including sexual and reproductive health. The primary objective of this study is to develop and evaluate the feasibility, acceptability, and usability of a sexually transmitted infection (STI) testing clinical decision support (CDS) tool within the electronic health record (EHR) among clinicians, adolescent patients, … |
BRIAN P. JENSSEN; | 2025-10-03 |
| 34 | A Digital Patient Decision Aid to Increase Sexually Transmitted Infection Testing in The Emergency Department: The STIckER Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a pilot randomized trial of STIckER in which 40 providers (20 trained in using the STIckER decision aid and 20 providing standard care) will enroll a total of 140 sexually active young Emergency Department (ED) patients over six months in a pediatric and adult ED setting. The primary goal is to determine if sexually active young individuals who use STIckER are more likely to undergo STI testing. By developing an effective automated digital tool to increase STI testing, the investigators aim to improve evidence-based sexual health education, reduce STI rates, … |
JASON E. ZUCKER; | 2024-04-01 |
| 35 | A Pilot Randomized Controlled Trial to Assess A Model of Decentralised STI-Self Testing and Risk Self-Assessment Among Adolescent Girls and Young Women in South Africa to Trigger PrEP Re-start PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a pilot randomized trial among 50 AGYW (aged ≥16≤18 years), who discontinued PrEP use within the past 6 months, assigned in a 1:1 ratio to receive: 1) STI self-test kits (Neisseria gonorrhoea (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV)) with in-person instruction at enrolment and telephone/video-based instructions for home use coupled with self-administered behavioural risk assessment or 2) self-administered behavioural risk assessment only (standard of care). All participants will receive comprehensive sexual and reproductive health (SRH) services during their study visits including choice of family planning method initiation and support, and behavioural HIV/STI risk reduction counselling. |
THESLA PALANEE-PHILLIPS; | 2024-08-01 |
| 36 | A Pharmacist-run, Community-based PrEP Program for High-risk Women-the OPTIMIZE Study Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to evaluate uptake and retention of long acting cabotegravir (LA-CAB) also known as Apretude versus daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) also known as Truvada for PrEP among high-risk women in metro-Orlando through week 48 (to also include reasons for lack of retention in PrEP care) |
ORLANDO IMMUNOLOGY CENTER | 2025-02-14 |
| 37 | Enhancing PrEP Outcomes Among Kenyan Adolescent Girls and Young Women With A Novel Pharmacy-based PrEP Delivery Platform PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators will conduct a cluster RCT in Kisumu, Kenya to determine the effect of nurse-navigators on PrEP initiation, persistence, and adherence among AGYW seeking contraception within a pharmacy-based PrEP delivery model. The study will randomize 20 retail pharmacies offering PrEP (10 pharmacies per randomization arm) and will enroll 1900 AGYW seeking contraception. All participants will be enrolled following purchase of a contraceptive method, offered PrEP (daily oral PrEP or the DPV-VR) and followed for 10 months. The study will quantify and compare PrEP initiation, persistence, and adherence at the pharmacy-level between randomization arms, … |
JILLIAN PINTYE; | 2025-06-27 |
| 38 | Implementation and Delivery of Cabotegravir Long Acting Injection for PrEP in A Community Pharmacy Setting PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this demonstration project or observational study is to evaluate the feasibility and acceptability of a pharmacist-managed cabotegravir long acting injectable for PrEP program in a community pharmacy setting. The main question it aims to answer are: * Is the program feasible and acceptable at the end of 1 year of operations? * What are the facilitators and barriers of the program? Participants who want to start the FDA approved cabotegravir long acting injectable medication for PrEP will have the option participating in surveys and a review of their electronic health records. Medication will be administered based on FDA approved labeling guidelines and their PrEP care will be part of standard of care per CDC. Pharmacists who want to provide the service to their patients will have the option of participating in surveys pre and post implementation. |
ELYSE TUNG; | 2025-07-29 |
| 39 | IGHID 12118 – Pay-it-forward Gonorrhea and Chlamydia Testing Among Men in China: The PIONEER Pragmatic Randomized Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: PIONEER is a three-arm, programmatic cluster randomized controlled trial (RCT) to compare effectiveness of three implementation strategies, followed by a mixed-methods implementation evaluation study |
JOSEPH D TUCKER; | 2025-12-03 |
| 40 | Impact of A Rapid Test for Gonorrhea and Chlamydia on The Clinical Management of Urethritis and Cervicitis in A Sexual Health Clinic PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a pilot randomized controlled trial evaluating the use of either a) rapid 30-minute desktop assay or b) point-of-care gram stain (current standard of care) to guide the clinical management of patients with symptomatic urethritis or cervicitis evaluated in the Massachusetts General Hospital Sexual Health Clinic. Patients presenting with symptoms of urethritis or cervicitis and meeting inclusion criteria will be randomized to have diagnostic specimens tested during the clinical encounter using either the 30-minute desktop assay or point-of-care gram stain. Patients randomized to the intervention arm of the study will also have a gram stain created, … |
INGRID V. BASSETT; | 2025-09-23 |
| 41 | Extraordinarily Fun Training Project in Compulsory Secondary Education-Sexually Transmitted Infections: Educational Intervention on STI in Adolescents From 1st&2nd Year of Compulsory Secondary Education Incorporating The Gender Perspective PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Project FEDE-ITS will improve the STI knowledge and its treatment, of adolescents in the 1st and 2nd year of compulsory secondary education in the intervention group compared to compared to the control group, and will modify the sexual risk practices and the perception of risky practices of alcohol and other drug use during sex of participants in the intervention group compared to the control group. |
DAVID PEDRAZAS-LÓPEZ; | 2023-09-01 |
| 42 | PrEP Rapid Access: An Open Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to determine the feasibility and acceptability of an intervention (Rapid PrEP Access) providing people who inject drugs (PWID) immediate access to PrEP prescriptions through same-day human immunodeficiency virus (HIV) self-testing, … |
SABRINA ASSOUMOU; | 2024-06-01 |
| 43 | Validation of Selected Point of Care Rapid STI Diagnostic Tests for Laboratory Based and Self- Test Use – A Sub-Study of Acceptability Research on Integrated Point of Care Sexually Transmitted Infection (STI) Testing and Expanded Partner Therapy (EPT) (ARISE) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this sub-study (PROVE) is to support and facilitate the validation of commercially available point of care (POC) sexually transmitted infection (STI) diagnostic test kits/devices for potential on-site laboratory use as well as bedside use in parallel to gold standard established testing methodologies. A further extension of bedside testing would include self-testing. |
THESLA PALANEE-PHILLIPS; | 2023-12-07 |
| 44 | Integrating Addiction and Infectious Diseases Services Into Primary Care in Rural Settings PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate an intervention strategy in introducing screen/evaluate/treat (SET) procedures for HIV/ hepatitis C/ and Opioid Use Disorder in Primary Care Clinics in West Virginia. The main questions it aims to answer are: * What are the barriers and facilitators to integrating evidence based practices for screening and treatment of HIV, hepatitis C, and Opioid Use Disorder into primary care clinics in West Virginia? * To assess the extent to which our SET processes are achieved through enhanced EHR tools, … |
FREDERICK L ALTICE; | 2025-04-17 |
| 45 | Effectiveness of Relationship Education for Reducing HIV Incidence in Men Who Have Sex With Men PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to upgrade an existing relationship education and HIV prevention program. This program is designed for gay, bisexual, queer, and transgender and non-binary people who partner with cisgender men. This means the program is designed for gay, bisexual and queer men, including both cisgender and transgender men. It is also designed for transgender and non-binary people who partner with cisgender men, … |
MICHAEL E. NEWCOMB; | 2026-03-31 |
| 46 | Pre-surgical Ultrasound Evaluation for Improving Patient Selection for VNOTES Approach PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is an emerging field in minimally invasive surgery. International consensus-based statement was recently published to help guide the basis for adopting vNOTES into clinical practice, including regarding patient selection. It was agreed that women with potential adhesions are not appropriate candidates for vNOTES approach including women with suspected adhesions due to history of severe pelvic inflammatory disease (PID) or endometriosis. However, as some pelvic infections might be asymptomatic, pre-operation imaging might be beneficial to complete improved selection of patients. Moreover, … |
AYA MOHR SASSON; | 2023-12-01 |
| 47 | Using Micro Electro Mechanical Systems to Detect The Air of Vaginal Discharge PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical study aims to train the algorithm and assess the performance of the Ainos Flora Women’s Vaginal Health Tester in identifying vaginal infections. |
FUNG-WEI CHANG; | 2023-02-01 |
| 48 | Improving HIV Prevention Among Adolescent Girls and Young Women (AGYW) in Uganda PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose: The purpose of the project is to determine oral pre-exposure prophylaxis (PrEP) preference among 14-24-year-old adolescent girls and young women (AGYW) at risk of HIV infection and to evaluate a peer support intervention aimed at improving uptake of and adherence to oral PrEP. Main Study Aims: i) To determine oral PrEP preference among 14-24-year-old AGYW at risk of HIV infection in Kampala, Uganda . ii) To evaluate a peer support intervention aimed at improving uptake of and adherence to oral pre-exposure prophylaxis (PrEP), … |
YUNIA MAYANJA; | 2025-08-01 |
| 49 | Assessing The Feasibility and Preliminary Impact of A MHealth App on Reducing STI Risk in Black MSM PrEP Users PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study will recruit 120 Black men who have sex with men (BMSM) from the local area, New Orleans. The main purpose of this research study is to test the effect of a new smartphone application, PCheck, on reducing the incidence of STIs, compared to routine care through the LSU-Crescent Care Sexual Health/PrEP Clinic. |
MEREDITH CLEMENT; | 2025-05-01 |
| 50 | A RCT for Chlorhexidine Gluconate As Treatment and Prophylaxis for Recurrent Vulvovaginal Candidiasis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The overall aim of this study is to investigate if vaginally applied 1% chlorhexidine gluconate (CHG) could be an alternative treatment to oral fluconazole (FLZ), both during an acute episode and as prophylaxis, against recurrent infections of vulvovaginal candidiasis (RVVC). RVVC is very common in fertile women. Up to six months of treatment with FLZ is recommended for RVVC. Over the last ten years, the use of FLZ has increased markedly in many countries. No major problems have been noted with resistance development, … |
NINA BOHM-STARKE; | 2025-12-31 |
| 51 | Expedited Partner Therapy and The HIV Prevention Cascade for MSM in Peru PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The HIV epidemic in Peru remains concentrated in the subpopulation of men who have sex with men (MSM), where the prevalence of disease has been estimated between 10-22% in recent epidemiologic surveys. Partner-based methods to limit the spread of HIV and STI co-infection, including partner notification and partner treatment, provide an important new strategy for HIV control in the region. Expedited Partner Therapy (EPT) has been shown to reduce rates of persistent or recurrent gonorrhea and chlamydia infection in heterosexual patients, … |
JESSE CLARK; | 2024-12-31 |
| 52 | Effect of Oral Probiotic Heat-killed Lactobacillus Johnsonii TCI250 or White Pomegranate Extract on The Vaginal Flora PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to explore the effect of Lactobacillus johnsonii and white pomegranate extract on female bacterial status, it aims to answer are: * Evaluate Lactobacillus johnsonii TCI250 probiotics or white pomegranate extract in regulating female vaginal bacteria and improving vaginal health. * Evaluate Lactobacillus johnsonii TCI250 probiotics or white pomegranate extract in regulating inflammation. Participants will be randomly assigned to placebo (n = 50), probiotic heat-killed Lactobacillus johnsonii TCI250 group (n = 50) and white pomegranate extract group (n = 50) for 8 weeks. Researchers will compare the vaginal flora and inflammation. |
SHIH CHIEN HUANG; | 2025-05-14 |
| 53 | Adapting Effective MHealth Interventions to Improve Uptake and Adherence of The HIV Pre-exposure Prophylaxis (PrEP) in Thai Young Men Who Have Sex With Men (MSM) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to develop and pilot test technology-based interventions to promote Pre-exposure Prophylaxis (PrEP) uptake and adherence among Thai young men who have sex with men (YMSM). |
BO WANG; | 2026-03-04 |
| 54 | A Randomized Crossover Study to Evaluate The Efficacy of Antibacterial Mouthwash in Preventing Pharyngeal Gonorrhea Among A High Risk Population PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to determine acceptability and preliminary efficacy of daily use of an antibacterial mouthwash as compared to a placebo mouthwash in reducing the incidence of pharyngeal gonorrhea among a cohort of HIV-positive and high risk HIV-negative men. Investigators plan to test the following hypotheses: 1. Participants will maintain a high level of adherence and satisfaction with daily mouthwash use. Furthermore, … |
MARJAN JAVANBAKHT; | 2026-02-13 |
| 55 | MWACh-PrEP: A SMS-based Support Intervention to Enhance PrEP Adherence During Pregnancy and Breastfeeding PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In high HIV prevalence regions, women are at high risk for HIV during pregnancy and breastfeeding. To protect women and reach elimination of mother-to-child HIV transmission, the World Health Organization recommends offering oral tenofovir (TFV)-based pre-exposure prophylaxis (PrEP) to HIV-negative pregnant and postpartum women in high-burden settings. Although most pregnant Kenyan women with HIV risk factors accept PrEP when offered, >50% discontinue PrEP within 30 days of initiation and sub-optimal adherence is common. To date, no intervention studies to improve PrEP adherence include pregnant or postpartum women. The investigators adapted an SMS communication platform (mWACh) to send PrEP-tailored, … |
JILLIAN PINTYE; | 2025-06-01 |
| 56 | PrEPTECH Phase 2 Study: Randomized-Controlled Trial of A Telehealth Intervention Delivering PrEP to Young Men Who Have Sex With Men and Transgender Women PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: PrEPTECH Phase 2 is a 2-arm randomized controlled trial to assess the effectiveness of a telehealth intervention in increasing PrEP uptake among cisgender men and transgender women who have sex with men over six months. Participants (N = 400) will be randomized equally into one of two study conditions, treatment with a telehealth intervention called PrEPTECH or a control condition consisting of treatment as usual plus access to a listing of online and local PrEP resources, … |
REBECCA BRAUN; | 2023-06-01 |
| 57 | Acceptability Research on Integrated Point of Care Sexually Transmitted Infection (STI) Testing and Expedited Partner Therapy (EPT) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This protocol builds on nearly a decade of collaborative HIV/STI prevention research to conduct a prospective cohort study of Adolescent Girls and Young Women (AGYW) eligible for PrEP in South Africa in which we will assess the acceptability of point-of-care STI testing plus Expedited Partner Therapy (EPT) and its impact on the incidence of common curable STIs over 12 months of follow-up. The social-behavioral scientist will undertake qualitative interviews with participants and their male partners to identify facilitators and barriers to EPT uptake and conduct a comparative cost analysis to estimate the cost per person tested using point-of-care STI testing with and without EPT incremental to the cost of standard of care. Findings from the proposed research will provide essential knowledge for national policymakers to advance approaches to STI screening and treatment that will lead to improvements in AGYW sexual reproductive health and reductions in STIs. The data generated from this project are essential to inform efforts to reduce the burden of STIs and HIV-1 in women and achieve the 2030 Sustainable Development Goals, which includes substantial reductions in HIIV and STIs in key at-risk populations. This project will support global efforts to substantially reduce STIs in key populations. |
THESLA PALANEE-PHILLIPS; | 2024-12-01 |
| 58 | Efficacy of Wet Cupping Therapy on Fibromyalgia Syndrome A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background and purpose: Although wet cupping therapy (WCT) is in use, clinical investigations of its efficiency are scarce. The aim of this study was to evaluate the effects of wet cupping therapy (WCT) on fibromyalgia syndrome Methods: The patients will be randomized into two groups. WCT will be applied once a month to patients in the intervention group while the control group will be on standard therapy for fibromyalgia. An evaluation will be made before treatment and at the 3rd month using the Fibromyalgia Impact Survey (FEA), VAS, and EuroQol-5D (EQ-5D-3L) quality of life scale. |
SULEYMAN ERSOY; | 2022-11-30 |
| 59 | The Guidance on The Gravitationally Assisted Lactation Influences The Occurrence of Lactational Mastitis: A Clinical Cohort Study PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Lactation is the instinct of almost all mammals, including human beings. With the development of human society, the function of lactation has gradually deviated from nature instinct. Breastfeeding related industries, such as milk bottles, formula and breast pumps, have formed a vast consumer market, leading to a transition from breastfeeding mothers’ individual instinct to the social division of labor. Previous studies found that the incidence of lactational mastitis remains largely unchanged post World War II with some reporting an increase, … |
JIANYI LI; | 2024-01-31 |
| 60 | Optimizing An MHealth Intervention to Improve Uptake and Adherence of The HIV Pre-exposure Prophylaxis (PrEP) in Vulnerable Adolescents and Emerging Adults PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main aim of this study is to develop technology-based interventions to improve HIV pre-exposure prophylaxis (PrEP) uptake and adherence among Thai young transgender women. |
BO WANG; | 2026-03-13 |
| 61 | Expanding The Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study utilizes a randomized controlled trial design to evaluate the efficacy of two intervention components for couples HIV testing and counseling (CHTC): a communication skills training video and a substance use module. Participants are randomized in a full-factorial design to one of 4 conditions: CHTC as usual; CHTC + communication skills training videos; CHTC + substance use module; or CHTC plus both adjunct components. |
TYREL STARKS; | 2025-12-16 |
| 62 | Multilevel Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: To achieve an AIDS-free generation, there is a critical need for programs which go beyond individual-level behavior change to reduce HIV and STI infections among adolescent girls and young women in sub-Saharan Africa. Informed, Motivated, Aware, and Responsible Adolescents and Adults (IMARA) is an evidence-based HIV-prevention intervention for adolescent girls and young women (AGYW) and their female caregivers, … |
GERI DONENBERG; | 2023-08-31 |
| 63 | Optimizing A Multi-Modal Intervention to Reduce Health-Risking Sexual Behaviors: Component Selection PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this project is to evaluate the components of the app-based intervention Mission Wellness to reduce health-risking sexual behaviors (HRSBs; e.g., condom non-use, multiple sexual partners) in active-duty members of the US Military to improve their sexual and reproductive health (SRH) and readiness to serve. Following the multiphase optimization strategy (MOST) framework, factorial component selection experiments (CSEs) will be conducted to evaluate which five experimental intervention components (i.e., Narratives, Skills, Scenarios, Future, and Risk) elicit the greatest improvements in the outcomes of interest given key constraints. |
RYAN R LANDOLL; | 2025-05-23 |
| 64 | Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective randomized controlled study examines whether the type of glove used (sterile vs clean) for cervical examination to assess progression in labor impacts the rates of intrapartum and/or postpartum infection in patients during labor or induction of labor at term. |
STACY SLAT; | 2022-09-01 |
| 65 | Game Plan: Testing The Efficacy of A Brief, Web-based Intervention in Reducing Heavy Drinking and Reducing Sexually-transmitted Infections Among High-risk Men Completing Self-testing PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed study involves conducting a larger-scale study exploring Game Plan’s effects among MSM in the real-world, alongside innovative approaches for expanding HIV testing. Using a hybrid 1 effectiveness-implementation approach, the investigators will recruit up to 360 high-risk, heavy drinking MSM online from several high-incidence areas in the US to participate in a program providing home-based HIV/STI self-tests in the mail at regular intervals over a year (baseline, 6 months, 12 months). Participants will be randomly assigned to receive access to either (1) a 24-hour helpline for counseling/referrals, … |
TYLER B WRAY; | 2025-05-07 |
| 66 | INTEGRA: A Vanguard Study of Health Service Delivery in A Mobile Health Delivery Unit to Link Persons Who Inject Drugs to Integrated Care and Prevention for Addiction, HIV, HCV and Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine the efficacy of using a mobile health delivery unit (mobile unit) to deliver one stop integrated health services – particularly medication for opioid use disorder (MOUD) and medication for HIV treatment and prevention – to people who inject drugs (PWID) with opioid use disorder (OUD) to improve uptake and use of MOUD, and uptake and use of antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP). |
HIV PREVENTION TRIALS NETWORK | 2026-02-20 |
| 67 | Randomized Trial Leveraging Electronic Health Record Data in A Risk Prediction Model to Increase HIV PrEP Uptake in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Kaiser Permanente Northern California (KPNC) has been a national leader in implementation of HIV preexposure prophylaxis (PrEP), a daily antiretroviral pill that is more than 99% effective in preventing HIV acquisition. However, many patients at risk for HIV at KPNC are not yet using PrEP, resulting in preventable infections each year. In prior work, … |
KAISER PERMANENTE | 2022-10-31 |
| 68 | PrEP Intervention for People Who Inject Substances and Use Methamphetamine PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, PrEP Intervention for people who Inject Substances and Use Methamphetamine (PRIME), we propose to assess if using video directly observed therapy with real-time contingency management (VDOT-CM) may help people assigned male sex at birth who have sex with men (MSM) who inject methamphetamine adhere to PrEP. We will randomize 140 adults who inject substances and use methamphetamine, are HIV-negative, and have recently engaged in a sexual HIV risk behavior to VDOT-CM or counseling alone for 24 weeks. The study aims are to (1) determine the efficacy of VDOT-CM compared to counseling alone for PrEP adherence, … |
PHILLIP COFFIN; | 2024-05-01 |
| 69 | Vaginal Microbiota Transplant to Promote Lactobacillus-dominant Cervicovaginal Communities PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized trial of vaginal microbiome transplant vs. saline placebo to restore a Lactobacillus dominant vaginal microbial community in women with recurrent bacterial vaginosis. |
DOUGLAS KWON; | 2025-07-18 |
| 70 | A Randomized Trial of Doxycycline Chemoprophylaxis for The Prevention of Sexually Transmitted Infections in Gay, Bisexual and Other Men Who Have Sex With Men (gbMSM) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: There is a growing epidemic of the bacterial sexually transmitted infections (STIs) syphilis, chlamydia and gonorrhea worldwide; similarly concerning trends have been noted in Canada, where increases of over 160% have been seen in bacterial STIs over the last decade. In Canada, gay, bisexual, and other men who have sex with men (gbMSM) – including those living with HIV – are disproportionately impacted by bacterial STIs5,6These dramatic increases in bacterial STIs, the potential development of serious complications including AMR, and waning effectiveness of the promotion of conventional STI prevention tools (e.g. condoms), … |
JONATHAN TROY GRENNAN; | 2025-03-31 |
| 71 | Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate different screening strategies to decrease the burden of Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV) among pregnant women, and reduce adverse birth outcomes. In turn it aims to evaluate the cost per pregnant woman screened and treated, cost of adverse birth outcomes, and cost-effectiveness per sexually transmitted infection (STI) and disability-adjusted life-year (DALY) averted. Furthermore, … |
ANDREW MEDINA-MARINO; | 2025-07-30 |
| 72 | Contingency Management for PrEP Adherence And/or Methamphetamine UseDisorder Among MSM and TW in Los Angeles: A Pilot Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Use of crystal methamphetamine (MA) leads to changes in sexual risk behavior, adherence to HIV prevention tools, immune response to infection, and tissue inflammation that collectively increase risk for HIV transmission among MA-using men who have sex with men (MSM), their sexual partners, and their networks. Contingency Management (CM) offers a behavioral modification tool helpful for reducing frequency of MA use, but the effects of CM on the behavioral and biological factors that promote HIV transmission in MSM networks have only been partially evaluated. The intersection of substance use, sexual risk behavior, … |
JESSE CLARK; | 2021-08-31 |
| 73 | Autologous Ovarian Tissue Transplantation Related Papers Related Patents Related Grants Related Experts Highlight: Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments. |
KYLE ORWIG; | 2025-08-14 |
| 74 | Immunisation for Adolescents Against Serious Communicable Diseases PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to implement a targeted 4CMenB immunisation program in young people aged 14-19 years in the Northern Territory (NT). As part of the NT program consenting 14-19 year olds will receive 2 doses of the licensed 4CMenB vaccine. An oropharyngeal swab will be collected on the same day as the first dose of the vaccine and 12 months later to assess carriage of Neisseria meningitidis. The first swab will assess baseline carriage prevalence among 14-19 year olds in the NT. The swab taken 12 months later will provide data on the change in carriage that may occur after implementation of the immunisation program. Emerging evidence suggests that the 4CMenB vaccine may be protective against gonorrhea. Therefore, vaccine effect (impact and effectiveness) against both invasive meningococcal disease (IMD) and gonorrhea in the NT will be assessed using data from the above study comparing notifications between vaccinated and unvaccinated as well as comparing pre and post implementation periods. |
HELEN MARSHALL; | 2024-12-31 |
| 75 | Combined Prevention of Sexually Transmitted Infections (STIs) in Men Who Have Sex With Men and Using Oral Tenofovir Disoproxil Fumarate/ Emtricitabine (TDF/FTC) for HIV Pre-Exposure Prophylaxis (PrEP) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The study ANRS 174 Doxyvac is a clinical trial that will use Combined Prevention of Sexually Transmitted Infections (STIs) in Men Who Have Sex with Men and using oral TDF/FTC for HIV Pre-Exposure Prophylaxis (PrEP) and vaccination with Bexsero. |
JADE GHOSN; | 2022-06-01 |
| 76 | A Phase II Randomized, Observer-Blind, Placebo-Controlled Study, to Assess The Efficacy of Meningococcal Group B Vaccine RMenB+OMV NZ (Bexsero) in Preventing Gonococcal Infection PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase II, randomized, observer-blind, placebo-controlled, multi-site trial of the FDA licensed rMenB+OMV NZ vaccine, Bexsero. The targeted study population is men and women 18-50 years of age who are disproportionately vulnerable to N. gonorrhoeae infection. Approximately 2,200 participants are expected to be enrolled to achieve at least 202 primary endpoints in the Per Protocol Population. Data will be collected in an observer-blind manner. Study product recipients and study staff responsible for the evaluation of any study endpoint will be unaware of whether Bexsero or placebo were administered. The duration of the study for participants who are enrolled and randomized will be approximately 16 months. Study participation is expected to be completed in approximately 36 months. The primary objective of the study is to demonstrate efficacy of Bexsero in prevention of urogenital and/or anorectal gonococcal infection. |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2026-03-20 |
| 77 | Integrating Cognitive-behavioural Therapy for Social Anxiety Disorder With HIV Risk Reduction Counselling for HIV-negative Gay and Bisexual Men Who Are at High Risk for HIV: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Given the continued high human immunodeficiency virus (HIV) prevalence rates among gay, bisexual, and other men who have sex with men (MSM) in North American cities, there is a critical need for HIV prevention interventions for MSM in Canada. Social anxiety, or anxiety about being evaluated in interpersonal and performance situations, is a reliable risk factor for condomless anal sex (CAS) among MSM. Social anxiety may also increase substance use in sexual situations, which is another risk factor for HIV among MSM. As such, … |
TREVOR HART; | 2025-05-30 |
| 78 | Prospective Cohort Trial To Assess Acceptability and Efficacy of An Adapted STI/HIV Intervention Behavioral Intervention Program in A Population of US Army Personnel and Their Medical Beneficiaries – Execution Phase PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The hypothesis is that a behavioral intervention tool adapted for the US military population will be acceptable and associated with a decrease in incident sexually transmitted infection (STI)/HIV rates and high-risk sexual behaviors, and increased self-reported condom use compared to the standard of care at the Joint Base Lewis-McChord (JBLM) Preventive Medicine clinic and the Fort Bragg Department of Public Health (part of Womack Army Medical Center). |
TATJANA CALVANO; | 2024-03-01 |
| 79 | Comparison of Cervical Intraepithelial Neoplasia 2/3 Treatment Outcomes With A Portable LMIC-adapted Thermal Ablation Device Vs. Gas-based Cryotherapy PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this academic-industrial partnership will be to compare two thermoablation modalities using devices adapted to low and middle income countries (LMICs) to traditional CO2-based cryotherapy for the treatment of cervical precancer. The investigators will investigate whether the cure rates of cervical intraepithelial neoplasia 2 and more severe diagnoses (CIN2+) with these devices are non-inferior compared to that of conventional cryotherapy. The results of this study will affect other research areas by serving as a springboard to exploring treatment alternatives that are amenable to low-resource settings and thus will reach the most vulnerable populations. |
MIRIAM CREMER; | 2025-07-17 |
| 80 | Pre-exposure Prophylaxis of HIV Infection Among Men Who Have Sex With Men (MSM) and Transgender Women (TG) in Suburban Yangon, Myanmar PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: HIV is concentrated among key populations in Myanmar. Globally, HIV-prevalence among transgender (TG) women is one of the highest; laboratory-confirmed prevalence is reported up to 40%. In September 2015, WHO recommended the use of Pre-Exposure Prophylaxis (PrEP) for people at substantial risk of HIV as part of a combination HIV prevention strategy. A demonstration project will take place to implement and evaluate the uptake and effectiveness of PrEP among MSM, and TG women in a clinic in Hlaingtharyar township, Yangon. The aim is to describe PrEP uptake, as well as HIV-seroconversion and STI infection rates among those who use PrEP. |
NINI TUN; | 2021-08-31 |
| 81 | Phase 3 Double-blind Placebo-controlled Efficacy Trial of EVO100 Vaginal Gel for The Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study will evaluate whether EVO100 vaginal gel prevents the sexual transmission of CT and GC infection |
EVOFEM | 2022-07-28 |
| 82 | Does Screening for Gonorrhea and Chlamydia Affect The Incidence of These Infections in Men Who Have Sex With Men Taking HIV Pre Exposure Prophylaxis (PrEP): A Randomized, Multicentre Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: A Multicentre, controlled, randomized trial of 3 site (urethra, pharynx and rectum) sampling performed every 3 months (3×3) for Neisseria gonorrhoea (Ng)/Chlamydia trachomatis (Ct) screening (comparator) vs. no screening (intervention). |
CHRIS KENYON; | 2022-08-31 |
| 83 | Improving The Detection of STIs in The Pediatric Emergency Department: A Pragmatic Trial PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: Sexually transmitted infections (STIs) are highly prevalent among adolescents. Clinical practices related to screening, diagnosis, treatment, and prevention of STIs among adolescents are suboptimal. There is a need to expand our screening programs to nontraditional healthcare settings such as emergency departments (ED) and to determine the most efficient and cost-effective method for providing this screening. The goal of this study is to leverage our recent insights obtained from single center ED-based adolescent GC/CT screening research and apply them across a national pediatric ED research network to determine the most clinically effective and cost-effective screening approach for adolescents when implemented into a real-world clinical setting through a pragmatic trial. This will be accomplished through a network of children’s hospital EDs with a track record of robust research collaboration (Pediatric Emergency Care Applied Research Network or PECARN). This intervention will rely on an innovative approach that electronically integrates patient-reported data to guide clinical decision support. The investigators will apply human factors modeling methods to perform ED workflow evaluations at each participating pediatric ED to determine the most efficient way to integrate the screening process into clinical care. The investigators will then conduct a comparative effectiveness pragmatic trial of targeted STI screening versus universally offered STI screening through electronic integration of patient reported data for provision of clinical decision support. The investigators will develop decision analytic models to evaluate the cost-effectiveness of targeted screening compared to universally offered screening. |
JENNIFER REED; | 2025-11-06 |
| 84 | Application of Vaginal-spraying LiveSpo X-secret in Supporting Treatment of Sexually Transmitted Diseases in Vietnamese Women PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Sexually Transmitted Infections (STIs) are common gynecological infections worldwide, especially in tropical and underdeveloped countries, primarily affecting the reproductive age group. Microbial pathogens causing STIs include bacteria, viruses, fungi, and protozoa. In Vietnam, STIs are a significant public health concern due to their high incidence and tendency to have mild or no symptoms, making them easy to overlook. While antibiotics or antifungal drugs are typically used to treat STIs caused by bacterial or fungal agents such as Chlamydia, Gonorrhea, and Candida, no specific treatment exists for most viral STIs. Thus, … |
HA TV BUI; | 2023-03-31 |
| 85 | Lactobacillus for Luteal Phase Support to Improve IVF Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to evaluate the effect of vaginal lactobacilli, a regulator of normal vaginal flora, on embryo implantation success during IVF / ICSI cycle follow-up. |
GÜRKAN UNCU; | 2020-06-01 |
| 86 | Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to understand if taking an antibiotic called doxycycline by mouth as soon as possible after sexual contact without a condom can reduce the risk of sexually transmitted infections (STIs), including gonorrhea, chlamydia and syphilis. The study will also look at the safety of doxycycline PEP and the impact that PEP may have on the bacteria that cause STIs as well as on bacteria that normally live on the body. While doxycycline is approved by the Food and Drug Administration (FDA), … |
ANNE LUETKEMEYER; | 2023-05-13 |
| 87 | Come As You Are – Assessing The Efficacy of A Nurse Case Management HIV Prevention and Care Intervention Among Homeless Youth PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to to determine the efficacy of the Nurse Case Management HIV (NCM4HIV) intervention on HIV prevention compared to usual care among Youth Experiencing Homelessness (YEH). |
DIANE SANTA MARIA; | 2025-06-26 |
| 88 | Multilevel Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Programs which go beyond individual-level behavior change to reduce HIV and STI infections among adolescent girls and young women in sub-Saharan Africa are essential to meet global HIV targets. Informed, Motivated, Aware and Responsible Adolescents and Adults- South Africa (IMARA-SA) is an evidence-based HIV-prevention intervention for adolescent girls and young women (AGYW) and their female caregivers, which has been adapted for a South African audience. This pilot study will assess feasibility in preparation for a randomized controlled trial (RCT). Additionally, … |
NATASHA CROOKS; | 2025-08-22 |
| 89 | A Phase III, Randomized, Multicenter, Open-Label Study in Adolescent and Adult Participants Comparing The Efficacy and Safety of Gepotidacin to Ceftriaxone Plus Azithromycin in The Treatment of Uncomplicated Urogenital Gonorrhea Caused By Neisseria Gonorrhoeae PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase III, randomized, multicenter, open-label study which will be performed to evaluate efficacy and safety of oral Gepotidacin compared to intramuscular (IM) ceftriaxone plus oral azithromycin for the treatment of uncomplicated urogenital infection caused by Neisseria gonorrhoeae (N. gonorrhoeae) in adolescent and adult subjects. In this study, subjects will be randomly assigned to receive either oral gepotidacin or IM ceftriaxone plus oral azithromycin. Approximately 600 subjects will be randomized to receive study treatment. The duration of the study will be approximately 21 days. |
XOLANI P MDLULI; | 2023-10-31 |
| 90 | Evaluation of EHealth Videos for The Singaporean Gay, Bisexual and Queer Male Community PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a pragmatic, randomized controlled trial design to evaluate an online video series developed by a community-based organization in Singapore for gay, bisexual and queer men. A total of 300 HIV-negative, gay, bisexual and queer men in Singapore aged 18 to 29 years old will be recruited with the assistance of the partner community-based organization (CBO), Action for AIDS Singapore. Recruitment will utilize both online and offline channels, and with the help of other CBOs in Singapore. Participants should also not have watched the video prior to their participation in this study, … |
TAN KAY JIN RAYNER; | 2020-07-06 |
| 91 | Pilot Peer Mentor Intervention to Train Black MSM to Use and Promote Home-based HIV and STI Testing PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objectives of the study are to assess the feasibility, reach and preliminary efficacy of a brief intervention that trains Black men who have sex with men [referred to as Index] (a) to use home-based testing for HIV and sexually transmitted infections and (b) promote home-based testing to their peers and sexual partners. |
JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH | 2022-07-30 |
| 92 | The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after a patient’s water bag has ruptured prematurely. If a patient has been diagnosed with rupture of their water bag between 18 0/7 weeks and 22 6/7 weeks and there are no other associated complications with the pregnancy, … |
ROBERT C MOORE; | 2021-07-01 |
| 93 | Are Rectal and Genital Chlamydia Trachomatis Infections in Women Related to Anal Sex, Autoinoculation / Contamination PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Chlamydia trachomatis is the most common cause of sexually transmitted bacterial infection in Sweden, an infection that is notifiable according to the Communicable Diseases Act and the Communicable Diseases Ordinance. Women account for 57 % of all cases detected since 1993. Recently published studies describe a high proportion of positive rectal chlamydia tests in women and in half of the cases there is no history of anal sex. In almost 20 % of cases, chlamydia has only been found rectally. Samples in these studies were self-collected and although the sensitivity of modern NAATs (Nucleic Acid Amplification Tests) is very high, … |
NAPOLEON KENTARCHOS; | 2022-08-01 |
| 94 | A Randomized, Placebo-controlled Trial of Oral Doxycycline for The Prevention of Syphilis in HIV-positive Men Who Have Sex with Men (MSM) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Syphilis is a sexually transmitted infection (STI) disproportionately affecting gay, bisexual and other men who have sex with men (gbMSM), with the potential for significant sequelae – particularly in those who are Human Immunodeficiency Virus (HIV)-positive. Rising rates of this STI have prompted a search for novel prevention solutions. A recent pilot study of daily doxycycline prophylaxis demonstrated promise as a novel STI prevention tool. This innovative approach to STI prevention has solid clinical precedent, both from the HIV pre-exposure prophylaxis (PrEP) literature, … |
JONATHAN TROY GRENNAN; | 2025-02-12 |
| 95 | Kyaterekera Project: A Combination Intervention Addressing Sexual Risk-Taking Behaviors Among Vulnerable Women in Uganda PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Guided by Social Cognitive and Asset theories as well as Behavioral Economics (BE) principles,the proposed RCT is carefully designed to test the additive contributions of savings-led microfinance beyond traditional HIV risk reduction (HIVRR) alone in decreasing biologically confirmed STIs, including HIV, improving high risk behavioral outcomes, while concurrently reducing income from sex work. Working within established health care- and outreach-based settings, we will randomly assign 990 FSWs to one of three study arms (11 town centers each): (1) a control arm comprising treatment as usual (TAU) for FSWs (quarterly 2-3 hour health education sessions, HIV testing services, and STI screening), … |
FRED SSEWAMALA; | 2025-04-09 |
| 96 | Improving Antibiotic Use in Urgent Care Facilities Through Implementation and Evaluation of Core Elements of Outpatient Antibiotic Stewardship PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: This study will implement a comprehensive outpatient stewardship program targeting a large network of Urgent Care (UC) clinics within Intermountain Helathcare. |
EDDIE STENEHJEM; | 2023-04-23 |
| 97 | Computer-Assisted Motivational Interviewing Intervention to Facilitate Teen Pregnancy Prevention and Fitness Behavior Changes: A Randomized Trial for Young Men PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The present study aims to test and rigorously evaluate the effectiveness of a computer-assisted motivational interviewing (CAMI) intervention that has already been shown to be successful with young women by reducing the risk of rapid subsequent birth among adolescent mothers, and applying this intervention to young men. The purpose of the intervention is to increase condom use, increase female partner use of moderately or highly effective contraception, … |
DAVID L. BELL; | 2019-08-28 |
| 98 | Aztreonam for Pharyngeal Gonorrhea: A Demonstration Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Centers for Disease Control and Prevention has identified antimicrobial-resistant (AMR) Neisseria gonorrhoeae (NG) as one of the nation’s top three urgent AMR threats. Since the advent of antibiotics in the 1930s, NG has developed resistance to every first-line antibiotic. Parenteral third-generation cephalosporins are now the only class of drug with consistent efficacy against NG. New therapies are urgently needed. Although some novel antimicrobials are under development, … |
LINDLEY BARBEE; | 2019-09-30 |
| 99 | A Double-blind Single Center, Crossover, Randomized Controlled Trial of Antibacterial Vs. Placebo Mouthwash to Reduce The Incidence of Gonorrhea/Chlamydia/Syphilis in MSM Taking HIV Pre-exposure Prophylaxis (PrEP) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study involves a randomized placebo controlled trial that aims to assess if a mouthwash (Listerine cool mint, LCM) is able to reduce the cumulative incidence of gonorrhoea (Ng), chlamydia (Ct) and syphilis in men who have sex with men and receiving preexposure prophylaxis (PrEP) at the Institute of Tropical Medicine (ITM). |
CHRIS KENYON; | 2020-06-15 |
| 100 | Comparing Specimen Collection Techniques to Screen for Sexually Transmitted Infections in Pregnant Women: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to compare two specimen collection techniques (vaginal vs. endocervical swab) to screen for sexually transmitted infections in pregnant women. Either a physician or the patient may collect the vaginal specimen; … |
KRISTA JENSEN; | 2019-09-27 |
| 101 | Protecting Our Future: Promotion of Protective Sexual Health Practices Among Native American Youth and Young Adults Through An Assets-based Self-care Intervention PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this research protocol is to test the efficacy of a self-care intervention through a randomized controlled trial (RCT), for increasing protective sexual health behaviors among youth in the participating Native American community. The investigators will randomize 450 youth and young adults ages 14-26 to the self-care intervention or a control program. Efficacy data will be collected up to 6 months post-intervention. The primary outcome will be uptake of sexually transmitted infection (STI) screening. Secondary outcomes will include: a) sexual risk and protective behaviors; … |
LAUREN TINGEY; | 2022-03-31 |
| 102 | Pay-it-forward Gonorrhea and Chlamydia Testing Among Men Who Have Sex With Men in China: A Cluster Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized controlled trial which will evaluate dual gonorrhea/chlamydia test uptake and other outcomes in men who have sex with men (MSM) in three trial arms – 1) a pay-it-forward testing arm, 2) a pay-what-you-want testing arm, and 3) standard of care arm. |
JOSEPH D TUCKER; | 2019-09-02 |
| 103 | Project PRIDE: Intervention to Reduce HIV Risk in Young Sexual Minority Men PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The specific aims are to: 1. Pilot test a randomized controlled trial of Project PRIDE for feasibility for subsequent research projects. A sample of 123 men aged 18-25 who identify as gay, bisexual, queer, or some other non-heterosexual identity, who are HIV negative, who report at least once instance of condomless anal sex in the absence of PrEP in the past 60 days, and who report drug use at least once in the past 60 days will be recruited and randomized to one of two conditions: 1. Project PRIDE: an eight-session primary HIV-prevention intervention; … |
NATHAN G. SMITH; | 2022-04-30 |
| 104 | Psychoeducational Intervention Through Meta – Universes on Self – Efficacy in The Use of Condoms and Sexual Behavior in University Students of The Autonomous University of Chile, 2018 PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In Chile, sexually transmitted infections (STI)s, including HIV / AIDS, are the main causes of morbidity in adolescents and young adults. The surveillance bulletin of the Institute of Public Health revealed an increase in cases of gonorrhea, over 200% in the last five years. HIV cases increased between 34% and 47% in this period as well. Unsafe sexual behaviors are among the most important risk factors for sexually transmitted infections (STI); it has been shown that educational / behavioral interventions can achieve success in behavioral changes, … |
ROSA JIMENEZ; | 2020-03-28 |
| 105 | Use of A Rapid Turnaround Test for Gonorrhea & Chlamydia to Improve Treatment of Women Presenting With Possible Sexually Transmitted Infections PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the effect of utilizing a rapid turnaround CT/NG test on treatment of female patients in the emergency department or urgent care setting with possible STIs. |
RICHARD GENTRY WILKERSON; | 2023-12-01 |
| 106 | Vaginal Self-sampling for Rapid Turnaround Gonorrhea/Chlamydia Testing in The Emergency Department PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Consenting adult female patient felt by the provider to require gonorrhea/chlamydia endocervical testing will be asked to provide an additional self sample specimen. The specimen will be sent to the laboratory using conventional diagnostic test for gonorrhea/chlamydia. |
BRIAN CHINNOCK; | 2020-06-09 |
| 107 | Gentamicin for Pharyngeal Gonorrhea – A Demonstration Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Centers for Disease Control and Prevention has identified antimicrobial-resistant (AMR) Neisseria gonorrhoeae (NG) as one of the nation’s top three urgent AMR threats. Since the advent of antibiotics in the 1930s, NG has developed resistance to every first-line antibiotic. Parenteral third-generation cephalosporins are now the only class of drug with consistent efficacy against NG. New therapies are urgently needed. Although some novel antimicrobials are under development, … |
LINDLEY BARBEE; | 2019-03-12 |
| 108 | HIV Pre-exposure Prophylaxis Implementation Study in South Korea PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to examine acceptability, patterns of use, rates of adherence, safety , and measured levels of drug when high risk men who have sex with men (MSM) are provided open-label tenofovir/emtricitabine (TDF/FTC) for PrEP in South Korea. Secondary objectives are 1) to evaluate HIV incidence among study participants, 2) to evaluate risk behavior and risk compensation among study participants, and 3) to identify barriers and facilitators of PrEP among study participants. The design of this study is a prospective, … |
JUN YONG CHOI; | 2022-12-01 |
| 109 | Prevention and Control of Neoplasms Associated With HPV in High-risk Groups in Mexico City: The Condesa Study PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: To evaluate the effectiveness of a combined strategy of human papillomavirus virus (HPV) vaccination and high-risk HPV screening to reduce the occurrence of neoplasms in the anogenital region and oral cavity among men who have sex with men, people with HIV, homeless people, transgender women, female sex workers and rape victims. Methods: This mixed methods study evaluates the effectiveness of a combined vaccination-screening strategy to reduce HPV prevalence/incidence and occurrence of cervical intraepithelial neoplasms grade 2+ and/or anal intraepithelial neoplasms grade 2+, … |
EDUARDO CESAR LAZCANO PONCE; | 2019-11-28 |
| 110 | Use of Tenofovir/Emtricitabine With Immediate or Deferred Doxycycline 100mg PO Daily for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative Men Who Have Sex With Men: A Pilot Study of Dual Daily HIV and Syphilis PrEP. (The DuDHS Trial) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Men who have sex with men remain at high risk for HIV infection. Targeting prevention interventions to MSM at highest risk of seroconversion is an important goal of combination prevention interventions. Antecedent diagnosis of another sexually transmitted infection (STI), particularly syphilis, may serve as an entry point for biomedical prevention as these individuals are at highest risk for incident HIV. The use of the antiretroviral combination of tenofovir/emtricitabine has been shown to be associated with an overall 44% reduction in HIV acquisition in high-risk MSM when taken daily as PrEP. In those individuals with detectable drug levels, … |
JONATHAN TROY GRENNAN; | 2020-06-30 |
| 111 | A New Approach to Integrating Primary and Secondary HIV Prevention in Young Male Couples PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Young gay, bisexual, and other men who have sex with men (YMSM) are the only risk group in which rates of new HIV infections are on the rise. There has been a relative dearth of research dedicated to understanding these health disparities between gay/bisexual and heterosexual youth, and even less has focused on identifying factors that might promote resilience against negative health outcomes. Understanding both risk factors and processes of resilience is critical in developing efficacious interventions to improve health in this population. Through a grant from the National Institutes of Health, … |
MICHAEL E. NEWCOMB; | 2022-04-01 |
| 112 | Using A Theory-based SMS/VM Intervention to Improve Sexual and Reproductive Health of Female Entertainment Workers in Cambodia: Study Protocol of A Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In Cambodia, HIV is prevalent in several high-risk groups including among female entertainment workers (FEWs) who work at entertainment venues such as karaoke bars and massage parlors and may engage in direct or indirect sex work. Reaching FEWs with sexual and reproductive health services such as testing and treatment for HIV and sexually transmitted infections (STIs) and contraception has been difficult because they are hidden and stigmatized. Mobile phone-based interventions may prove to be an effective way to reach this population and connect them with the existing services. This article describes study design and implementation of a two-arm randomized controlled trial of a mobile health intervention (the Mobile Link) aiming to improve sexual and reproductive health outcomes among FEWs in Cambodia. A two-armed randomized controlled trial (RCT) will be used to determine the effectiveness of a mobile phone-based text/voice messaging intervention. The intervention will be developed through a participatory process; 50 FEWs will work alongside researchers in focus groups to modify and tailor behavior change theory-based text and voice messages. Then, 600 FEWs will be recruited and randomly assigned into one of two arms: (1) a control group and (2) a mobile phone message group (either text messages or voice messages, delivery method chosen by participant). The primary outcome measures include HIV testing, condom use, STI testing and treatment and contraceptive use. If the Mobile Link trial is successful, an increase in condom use, screening and treatment for HIV and STI and contraception use is expected. These outcomes would lead to a reduction in the prevalence of HIV, STIs and unintended pregnancies. This trial is unique in a number of ways. First, the option of participation mode is offered to allow participants to choose the message medium that best links them to services. Second, this is the first RCT of a mobile phone-based behavior change intervention using SMS/VMs to support linkage to sexual and reproductive health services in Cambodia. Third, we are working with is a hidden, hard-to-reach and dynamic population with which traditional methods of outreach have not been fully successful. |
TOURO UNIVERSITY CALIFORNIA | 2019-04-01 |
| 113 | Suubi4Her: A Combination Intervention Addressing HIV Risk Behaviors Among Older Adolescent Girls Transitioning Into Adulthood in Uganda PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study examines the impact and cost associated with Suubi4Her, an innovative combination intervention that aims to prevent HIV risk behaviors among 15-17 year-old girls living in communities heavily affected by poverty and HIV/AIDS in Uganda. Participants will be randomly assigned at the school level into one of three study conditions: 1) Savings (Youth Development Accounts – YDA) – with a 1:1 incentive match rate – for education and microenterprise development; 2) Savings (YDA) + Multiple Family Groups intervention; … |
FRED SSEWAMALA; | 2021-03-30 |
| 114 | The PREMISE Trial: A Novel Regimen to Prevent Malaria and Sexually Transmitted Infections in Pregnant Women With HIV PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: More than 3 billion people worldwide are at risk of acquiring malaria and pregnant women living with HIV in Africa are at particular risk. An effective prophylaxis regimen capable of preventing malaria and other common perinatal infections would have great potential to improve adverse birth outcomes. The purpose of this randomized controlled trial is to evaluate a new combination prophylaxis regimen in pregnant women with HIV in Cameroon to determine its efficacy and safety. |
JODIE DIONNE-ODOM; | 2022-01-01 |
| 115 | Couples Health Project: Couples-based Intervention to Reduce Drug Use and HIV Transmission Risk PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This project tests the feasibility, acceptability, and preliminary efficacy of the Couples Health Project (CHP). CHP is a brief (3-session) couples-based Motivational Interviewing intervention which addresses drug use and sexual HIV transmission risk among partnered HIV negative YMSM (ages 18-29). The proposed project includes a randomized controlled trial (RCT) involving 50 couples who are randomized to complete either the CHP intervention or an attention-matched education control condition. |
TYREL STARKS; | 2020-09-14 |
| 116 | Youth-focused Strategies to Promote Adherence to Pre-exposure Prophylaxis Among Youth At-risk for HIV in Thailand PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A randomized controlled clinical trial looking at the effect of use of a mobile phone application in addition to standard care compared to standard care alone at a youth-friendly clinic in young men who have sex with men and transgender women aged between 15-19 years at risk of HIV on PrEP adherence. |
WIPAPORN NATALIE SONGTAWEESIN; | 2019-12-15 |
| 117 | Intervention to Reduce Drug Use and HIV Incidence Among High PrEP Priority Partnered YMSM PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This research examines the efficacy of an individually-delivered intervention tailored for YMSM in relationships. The intervention – termed PARTNER – utilizes a brief (4 session) motivational interviewing format to target Pre-Exposure Prophylaxis (PrEP) uptake/adherence, HIV transmission risk behavior, and associated drug use. |
TYREL STARKS; | 2025-10-29 |
| 118 | Enhanced SexHealth Intervention to Improve Adolescent Outcomes: A Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an adaptive trial with an initial Formative Revision Process followed by a Randomized Controlled Trial (RCT). Up to 500 adolescents will be consented into this study to achieve 6 completed subjects for the formative process and 86 completed subjects for the RCT. |
MELISSA MILLER; | 2020-05-01 |
| 119 | A Structural HIV Prevention Intervention Targeting High-risk Women PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the effectiveness of a community based combination HIV prevention package, including biomedical, behavioral, and structural services for female sex workers (FSW) in Baltimore, Maryland. This study is a prospective two-group trial comparing the efficacy of a community-based comprehensive HIV/STI prevention package compared to standard of care (HIV testing, counseling, and referrals) among FSWs. Outcomes will be assessed through self-reported illicit drug use and sexual risk behaviors (behavioral) as well as HIV/STI testing (biological). |
SUSAN SHERMAN; | 2020-09-22 |
| 120 | Efficacy of Couples-Based HIV Prevention in Vulnerable Young Men PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Young gay, bisexual, and other men who have sex with men (YMSM) are the only risk group in which rates of new HIV infections are on the rise. There has been a relative dearth of research dedicated to understanding these health disparities between gay/bisexual and heterosexual youth, and even less has focused on identifying factors that might promote resilience against negative health outcomes. Understanding both risk factors and processes of resilience is critical in developing efficacious interventions to improve health in this population. Through a grant from the National Institutes of Health, … |
MICHAEL E. NEWCOMB; | 2022-06-30 |
| 121 | A Randomized Controlled Trial Comparing Cure Rates of Cervical Intraepithelial Neoplasia Grade 2 and Higher (CIN2+) Treated With CO2-based Cryotherapy, CropPen, and Thermoablation (UH3) PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this academic-industrial partnership will compare the CryoPen® and thermoablator to traditional CO2-based cryotherapy for the treatment of cervical precancer in low and middle income countries (LMICs) and investigate whether the cure rates of cervical intraepithelial neoplasia 2 and more severe diagnoses (CIN2+) with these devices are non-inferior compared to that of conventional cryotherapy. The results of this study will affect other research areas by serving as a springboard to exploring treatment alternatives that are amenable to low-resource settings and thus will reach the most vulnerable populations. |
MIRIAM CREMER; | 2023-07-31 |
| 122 | Mobile-Based Application MyChoices to Increase Uptake of HIV Testing, Detection of New HIV Infections, and Linkage to Care and Prevention Services By Young Men Who Have Sex With Men PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is testing the acceptability and feasibility of MyChoices, a mobile application (app), to promote HIV testing and pre-exposure prophylaxis (PrEP) uptake among young men who have sex with men (YMSM). |
KENNETH H. MAYER; | 2020-01-31 |
| 123 | Re-enrolling Young South African Mothers in School As A Social Vaccine Against HIV Transmission PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the efficacy of an intervention designed to reduce STI/HIV incidence by increasing the number of adolescent mothers who re-enroll and remain in school. The objective of the intervention is to have older mentor mothers, who themselves were pregnant adolescents, to mentor younger adolescent mothers. Mentor mothers will provide ongoing psychosocial support, help navigate re-admission to school, and help facilitate access to an existing State-sponsored cash transfer, the child support grant (CSG), … |
ALLISON K GROVES; | 2018-11-30 |
| 124 | A Cohort for Evaluation of Open-label PrEP Delivery Among Kenyan and South African Women: The POWER Cohort PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The POWER Cohort study is a PrEP implementation project to demonstrate Pre-exposure prophylaxis (PrEP) delivery for young women in Cape Town and Johannesburg, South Africa and Kisumu, Kenya. |
CONNIE CELUM; | 2021-07-23 |
| 125 | STD Testing in Outpatient Practices-The STOP STDs Study PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: National guidelines have recommended routine STD screening (chlamydia and gonorrhea) for sexually active young women under the age of 25. Despite these recommendations, many young women are not being screened for STDs, with some estimates that less than 50% of women receiving health care are screened for chlamydia. Untreated STDs can lead to important sequelae to women’s reproductive health including pelvic inflammatory disease, … |
HAROLD WIESENFELD; | 2020-12-30 |
| 126 | A New Approach to Controlling Chlamydia Transmission in Young People PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study, named Check it, is a bundled program for African American (AA) men ages 15-24 that includes community testing for chlamydia and gonorrhea, expedited treatment for subjects who test positive and their female sexual contacts, and rescreening for these two sexually transmitted infections. |
PATRICIA KISSINGER; | 2021-05-28 |
| 127 | Evaluating The Effectiveness of An EHealth EBI for Latino Youth in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to test the relative effectiveness of a Hispanic-specific eHealth intervention, e-Health Familias Unidas, in preventing and reducing drug use, sexual risk behaviors, and STIs among Hispanic youth in primary care. Families will be recruited through four pediatric primary care settings. Pediatric staff and research team members, including nurse assistants and mental health professionals, will implement eHealth Familias Unidas. |
GUILLERMO PRADO; | 2022-12-18 |
| 128 | The Effect of Social Media Support and Financial Incentives on Adherence to HIV Pre-exposure Prophylaxis in Young MSM of Color in Washington, DC PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if social media support and financial incentives improve adherence to Truvada as PrEP in African American, Latino and Asian MSM aged 18 to 24 living in the Washington, DC area who are at high risk for HIV acquisition. |
MARC O. SIEGEL; | 2020-12-15 |
| 129 | Ovarian Tissue Freezing For Fertility Preservation In Women Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research is to obtain ovarian tissue from female participants who will receive therapy which is expected to result in a loss or impairment of ovarian function and/or infertility and wish to preserve (freeze) ovarian tissue for the purpose of initiating a pregnancy in the future. Removal of the ovary for cryopreservation is an investigational procedure. 100% of the tissue will be used for the participant’s future use. There have been 86 pregnancies as a result of frozen ovarian tissue that has been re-implanted back into the pelvis and hormonal function has been restored in individuals for up to 7 years. By doing this study, the investigators hope to learn of how to successfully freeze and thaw ovarian tissue in a manner that permits subsequent use by patients at some point in the future. Participation may also advance our knowledge of how to successfully mature follicles and oocytes (eggs) that are contained in these tissues which may help others in the future. |
VLAD RADULESCU; | 2017-06-21 |
| 130 | Evaluation of An Inpatient Sexual Risk Behavior Assessment Program PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an exploratory pilot study to evaluate the feasibility and potential effects of an innovative, individualized electronic inpatient sexual health intervention (iRAP) for adolescent females. The central hypothesis is that the electronic intervention, a sexual health questionnaire with tailored feedback based on the Trans Theoretical Model (TTM) of behavior change, will significantly increase adolescent females’ requests for sexually transmitted infection (STI) screening and sexual health management during their hospital admission. |
RHODE ISLAND HOSPITAL | 2017-10-29 |
| 131 | A Randomized Controlled Trial Evaluating Efficacy of Promoting Voluntary Medical Male Circumcision Among Male Sexually Transmitted Diseases Patients in China PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A parallel-group, non-blinded randomized controlled trial was conducted. Participants were uncircumcised heterosexual male sexually transmitted disease patients attending the four collaborative public sexually transmitted diseases clinics in three Chinese cities. Those who were known to be HIV positive were excluded. After completion the baseline face-to-face interview, 238 participants will be randomized 1:1 into the intervention group and the control group. Participants in the control group will receive a health education booklet introducing voluntary medical male circumcision. In addition to the health education booklet received by the control group, … |
ZIXIN WANG; | 2018-04-30 |
| 132 | Use of Condoms in Prevention of Progression of Cervical Intraepithelial Neoplasia: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Women who are diagnosed with CIN2 and who have a pregnancy wish are followed up 6 months after the diagnosis with new examinations. The regression rate is based solely on the woman’s own ability to clear the cervical lesions. The use of condoms has shown a relatively good protective effect against Human Papillomavirus (HPV) infection. It has furthermore been indicated that condoms increase the regression rate of cervical lesions. The hypothesis of this study is that the regression rate of cervical intraepithelial neoplasia grade 2 (CIN2) increases when condoms are used consistently in the follow-up period of 6 months. |
MALENE SKORSTENGAARD; | 2019-09-01 |
| 133 | Clinical Evaluation of The Aptima® Combo 2® Assay Using The Panther® System in Female Urine Samples PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to evaluate the performance characteristics of the AC2 assay on the Panther system using female urine specimens. |
HOLOGIC | 2017-03-01 |
| 134 | Emergency Department, Rapid Assessment for Sexually Transmitted Infection PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate if a rapid urine Nucleic Acid Amplification Testing (NAAT) is non-inferior to the traditional swab NAAT for gonorrhea and chlamydia when performed in the Emergency Department. |
JOSEPH MILLER; | 2016-06-01 |
| 135 | Pilot Feasibility Study: Recruiting African American Fathers and Their Adolescent Sons for Qualitative, Sexual Health Research PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to develop and pilot test recruitment methods for a future study of prevention of sexually transmitted infections (STI), including the human immunodeficiency virus (HIV), among Black adolescent boys through sexual health education by their fathers. |
SCHENITA RANDOLPH; | 2017-02-01 |
| 136 | A Couple-based HIV Prevention Intervention to Promote HIV Protection Among Latino Male Couples PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Epidemiological studies have attributed the source of many new HIV and STI infections among MSM to primary partners. Despite recent emphasis on couples-based interventions, efficacious interventions for Latino male couples have yet to be tested. The proposed study builds on the PI’s post-doctoral research in which he adapted evidence based intervention for Black MSM couples, Connect ‘n Unite, for Latino male couples using methodologically rigorous adaptation procedures. The adapted intervention, Conectado Latinos en Parejas (CLP) expands the prevention alternatives offered in previous interventions by incorporating biomedical prevention methods such as pre-exposure prophylaxis (PrEP), promoting engagement in care, … |
OMAR MARTINEZ; | 2020-04-01 |
| 137 | Nurse-Family Partnership Impact Evaluation in South Carolina PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the effects of the Nurse Family Partnership (NFP), an established home-visiting program, using a scientifically rigorous individual-level randomized controlled trial. The study will be based in South Carolina, where a Medicaid waiver in combination with a pay-for-success contract will allow expansion of the program to women on Medicaid. The study plans to enroll 4000 low-income, first time mothers and their children into the intervention group, … |
MARGARET MCCONNELL; | 2025-12-12 |
| 138 | A Randomized Study Evaluating An Intervention Integrating Economic Strengthening and HIV Prevention Programs for Vulnerable Youth in South Africa PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates whether the integration of an Economic Strengthening program with an HIV-prevention education program produce synergistic effects on economic and health outcomes for South African youth ages 14-17 years old. |
HOLLY BURKE; | 2018-05-31 |
| 139 | Pilot of An MHealth-enhanced, Safer Conception Intervention to Reduce HIV-1 Risk Among Kenyan HIV-1 Serodiscordant Couples PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The greatest burden of the HIV-1 epidemic lies in sub-Saharan Africa, where a substantial proportion of infections occur in long-term heterosexual HIV-1 serodiscordant partnerships. Such couples face a difficult dilemma when considering their desire to have children: forego condom use, attempt to conceive and risk HIV-1 transmission or continue condom use and relinquish their childbearing desires. Based on evidence from rigorous clinical trials demonstrating the strong efficacy of individual interventions for HIV-1 prevention and formative work with HIV-1 serodiscordant couples and clinicians with expertise in HIV-1 prevention and reproductive health in the Kenyan context, … |
RENEE HEFFRON; | 2018-07-01 |
| 140 | Multimedia HIV/STI Prevention for Black Drug-Involved Women on Probation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed study is a randomized controlled trial (RCT) that will rigorously evaluate the effectiveness and cost-effectiveness of delivering a multimedia evidence-based intervention (WORTH) and streamlined HIV testing to prevent human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs) with Black/African-American (hereafter referred to as Black) women drug users in probation sites in New York City (NYC), compared to streamlined HIV testing alone. Repeated assessments will occur at baseline and 3, 6, and 12-months post intervention. The primary outcomes will be to reduce cumulative incidence of biologically confirmed STIs (i.e., Chlamydia, … |
LOUISA GILBERT; | 2019-09-01 |
| 141 | Validity of Patient-Collected Wet Mounts PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose/Objectives: To compare wet mount findings for clue cells, yeast, trichomonads and white blood cells per high-power field in self-collected vaginal specimens, compared to clinician-collected specimens, among symptomatic women visiting the San Antonio Metropolitan Health sexually transmitted disease clinic. Research Design/Plan: Prospective, non-randomized, non-blinded trial Methods: Obtain informed consent and specimens from 40 symptomatic adult females (eg abnormal discharge, odor and/or itching). Calculate concordance between clinician- and patient-collected samples using a Wilcoxon Matched-Pair test. Calculate sensitivity, specificity, positive predictive value and negative predictive value of the patient-collected wet mount, … |
JUNDA WOO; | 2016-08-01 |
| 142 | A Study Evaluating Efficacy and Safety of Ceftriaxone Sodium and Sulbactam Sodium for Injection in The Treatment of Uncomplicated Urogenital Gonorrhea PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phaseIV, multicenter, open-label，single arm study which will be performed to evaluate efficacy and safety of Ceftriaxone sodium and Sulbactam Sodium for injection for the treatment of uncomplicated urogenital infection caused by Neisseria gonorrhoeae in adolescent and adult subjects. |
PINGYU P ZHOU; | 2016-05-30 |
| 143 | Randomized Controlled Trial of An Adapted STD Screening and Risk Reduction Intervention PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this research study is to evaluate the impact of a paraprofessional-delivered, culturally adapted, evidence-based intervention (EBI) on sexually transmitted disease (STD), substance use and poor mental/emotional health among American Indians (AI) through a Randomized Controlled Trial (RCT). These intertwining risks have produced marked disparities and have unique cultural and social determinants in Native communities. If aims are achieved, scientific knowledge and community-based practice will be advanced in areas vital to AI communities, and to STD and drug prevention science. Prior to this study, … |
LAUREN TINGEY; | 2019-07-01 |
| 144 | Culturally Congruent HIV Risk Reduction App for Young Women, An Acceptability & Pilot Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Smartphone applications and mobile technologies offer users the potential to access critical information (e.g., proper condom use, directions to testing sites, and other sexual and reproductive health services) when it is needed most. Relevant findings will identify areas where existing interventions may be leveraged and adapted to work among young women of color in an urban setting and their networks. As SRH smartphone apps continue to proliferate, this study will expand researchers’, developers’, and health educators’ limited knowledge about the feasibility, acceptability and preliminary efficacy of a sexual health educational app tailored with and for young Black and Latino women, … |
CITY UNIVERSITY OF NEW YORK SCHOOL OF PUBLIC HEALTH | 2016-06-01 |
| 145 | Reducing Diagnostic Errors in Primary Care Pediatrics PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The proposal will focus on 3 specific, high-risk, pediatric ambulatory diagnostic errors each representing a unique dimension of diagnostic assessment: evaluation of symptoms, evaluation of signs and follow-up of diagnostic tests. Adolescent depression (i.e. symptoms) affects nearly 10% of teenagers, is misdiagnosed in almost 75% of adolescents and causes significant morbidity. Pediatric elevated blood pressure (signs) is misdiagnosed in 74-87% of patients, often due to inaccurate application of blood pressure parameters that change based on age, … |
MICHAEL RINKE; | 2017-10-31 |
| 146 | Fostering Resilience to Psychosocial and HIV Risk in Indian MSM PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: India has the world’s third largest HIV epidemic and men who have sex with men (MSM) are an identified high risk group. MSM in India face unique psychosocial stress underlying the context of HIV risk. To maximize the potential impact of an HIV prevention intervention, the purpose of this study is to test, in a two-arm randomized controlled efficacy trial, a behavioral intervention that addresses both psychosocial / contextual stress and reducing participant’s risk for HIV. |
STEVEN A. SAFREN; | 2019-08-01 |
| 147 | A Phase II, Randomized, Multicenter, Dose-Ranging Study in Adult Subjects Evaluating The Efficacy, Safety, and Tolerability of Single Doses of GSK2140944 in The Treatment of Uncomplicated Urogenital Gonorrhea Caused By Neisseria Gonorrhoeae PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: GSK2140944 has demonstrated in vitro activity against Neisseria (N.) gonorrhoeae, including ciprofloxacin resistant and susceptible strains. This study is a Phase II, randomized, multicenter, open-label, dose ranging study designed to inform the optimal oral dose of GSK2140944 by further characterizing the efficacy, safety, … |
GLAXOSMITHKLINE | 2016-07-27 |
| 148 | Effectiveness of A Patient Centered Intervention to Increase Dual Protection Against Unintended Pregnancy and Sexually Transmitted Disease Among Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to use a text messaging intervention to prevent unintended teen pregnancy and transmission of sexually transmitted disease. The study will be informed by a formative qualitative phase (February 2014 – January 2015) which will include individual qualitative interviews and focus groups with teens to elucidate and explore the barriers to effective contraceptive use and sexually transmitted disease (STD) prevention and to obtain feedback on the developed intervention. The second efficacy phase will randomize subjects to the texting intervention or to usual care. |
DEBORAH RINEHART; | 2017-01-01 |
| 149 | Asymptomatic Sexually Transmitted Infections (STI) : Comparison of Two Screening Strategies Routine Screening Versus Screening As Reported By The Risks Taken By The Patient, in A Cohort of HIV Outpatients Men Who Have Sex With Men PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Comparison of two screening strategies of asymptomatic sexually transmitted infections : routine screening versus screening as reported by the risks taken by the patient, in a cohort of HIV outpatients men who have sex with men. The aim of this study will be create and validate a simple tool for clinicians. A digital tool will be developed will allowed empowerment of HIV-positive men who have sex with men. |
DAVID ZUCMAN; | 2017-04-14 |
| 150 | Evaluating A Microfinance Intervention for Vulnerable Women in Kazakhstan PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will examine the efficacy of a combined HIV and microfinance intervention to reduce biologically confirmed sexually transmitted infections (STIs), and new incidence of HIV and HCV, as well as reported sexual and drug risk behaviors among 520 women who have injected drugs in the past year and who engage in sex trading in Temirtau and Pavlodar, Kazakhstan. The proposed study builds on findings from an R34 by the investigative team testing a combination HIV prevention and microfinance intervention. Building on successful protocols and significant results, … |
SUSAN WITTE; | 2018-08-01 |
| 151 | Rapid Diagnosis of Antibiotic Resistance in Gonorrhoea: RaDAR-Go PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to develop a laboratory-based assay that will be a real-time PCR test to detect the organism N. gonorrhoeae and its most important genetic markers of antimicrobial resistance. This study will also determine factors associated with gonorrhoea and describe sexual behaviours of men who have sex with men, to inform parameters for a mathematical model of gonorrhoea transmission and antimicrobial resistant gonorrhoea. |
NICOLA LOW; | 2016-08-01 |
| 152 | Randomized Controlled Trial of Treatment of Male Partners of Women With BV PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Male partners of womoen with recurrent bacteria vaginosis are randomized to treatment with metronidazole or placebo to compare the rates of recurrent BV in the women |
JANE SCHWEBKE; | 2019-03-01 |
| 153 | A Phase 1, Open-Label, Within-Subject Dose-Escalation Study to Evaluate The Clinical Vulvar-Vaginal Safety and Pharmacokinetic Profile of SST-6006, A Topical Sildenafil Cream (5% W/w), in Healthy Postmenopausal Women PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 1, single center, open-label, within-subject dose-escalation study evaluating the safety and pharmacokinetics of SST-6006 in healthy postmenopausal women. Three dose levels of SST-6006 and a placebo regimen will be evaluated: 1 g (0 mg of sildenafil), 1 g (50 mg of sildenafil), 2 g (100 mg of sildenafil), and 4 g (200 mg of sildenafil). Doses will be administered sequentially and will be separated by a 14-16 day washout period. All 3 dose levels and the placebo will be applied both externally and internally. |
KEN LASSSETER; | 2015-05-01 |
| 154 | A Randomized, Open-label Phase 2 Study to Evaluate The Efficacy and Safety of A Single Dose of Oral AZD0914 Compared to Intramuscular Ceftriaxone in The Treatment of Male and Female Subjects With Uncomplicated Gonorrhea PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multi-center Phase 2 randomized, open-label study in approximately 180 adult male and female subjects, between the ages of 18 and 55, who are in good health and meet all eligibility criteria. The study is designed to assess the safety and efficacy of an antimicrobial investigational product, AZD0914 manufactured by AstraZeneca, administered to adults to treat uncomplicated urogenital gonorrhea compared to treatment with ceftriaxone. Subjects will be randomly assigned 70:70:40 to receive a single, oral dose of 2000 mg of AZD0914, 3000 mg of AZD0914, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2015-12-30 |
| 155 | Self-Obtained Vaginal Swabs for Chlamydia and Gonorrhea Testing: Concurrence in Non-Clinical Settings Vs. Clinical Settings PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the agreement between NAAT results for Chlamydia trachomatis and Neisseria gonorrhoeae infection obtained with self-obtained vaginal swabs (SOVS), collected in a non-clinical setting vs. NAAT results using SOVS collected in a clinical setting. This is a new use of this specimen type as SOVS are FDA cleared only for use in clinics. The NAAT (Gen-Probe APTIMA Combo 2® Assay (AC2)) result with the home-collected SOVS specimen will be compared to the result obtained with an SOVS collected in the clinic on multiple platforms (Direct Tube Sampling (DTS) / Panther / Tigris). The term home-collected is used to refer to any specimen that is not collected in a clinic, since there is no certainty that a specimen is collected at home or in a restroom in an office setting, etc. To compare the SOVS results to an FDA cleared predicate test with the collection of two clinician collected vaginal swabs. |
UNIVERSITY OF CALIFORNIA SAN FRANCISCO | 2015-12-01 |
| 156 | An Open-Label, Randomized, Multi-Center Study to Evaluate The Efficacy and Safety of A Single Dose of Oral Solithromycin Compared to Single-Dose Intramuscular Ceftriaxone Plus Single-Dose Oral Azithromycin in The Treatment of Male and Female Patients With Uncomplicated Urogenital Gonorrhea With or Without Concomitant Chlamydia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will compare a single dose of oral solithromycin to the standard of care (intramuscular ceftriaxone plus oral azithromycin) in the treatment of patients with urogenital gonorrhea. A completed open-label Phase 2 study with single doses of solithromycin resulted in 100% microbiological eradication in male and female patients with uncomplicated urogenital gonorrhea. |
MARCUS CHEN; | 2017-02-22 |
| 157 | Controlled, Multicenter, Randomized Parallel Group Pilot Study With 2 Treatment Arms in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis (BV) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Bacterial vaginosis (BV) is the most common cause of vaginitis in women of childbearing age. Women with symptomatic BV may present with malodorous discharge that is off-white, thin, and homogenous and has a fishy smell especially after intercourse. It is of importance to treat women with BV, as this condition is associated with serious risks, such as an increased risk of preterm birth in pregnant women, … |
UNIVERSITY HOSPITAL INSELSPITAL BERNE | 2020-03-19 |
| 158 | Back to BASICS: Boric Acid, Alternate Solution for Intravaginal Colonization, Comparing Intravaginal Metronidazole to Boric Acid in Women Symptomatic for Bacterial Vaginosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Bacterial vaginosis (BV), the world’s most common vaginal infection, continues to cost patients time, energy, comfort and money. BV is associated with increased incidence of sexually transmitted infections (including HIV), spontaneous abortion, pre-term labour, post-surgical infections, and endometritis. Current treatment for those women symptomatic for BV includes both oral and intravaginal antibiotics, such as metronidazole, … |
KONIA TROUTON; | 2016-02-01 |
| 159 | Limiting HIV Target Cells By Inducing Immune Quiescence in The Female Genital Tract PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In this project, the investigators want to analyse the capacity of Acetylsalicylic acid and hydoxychlroquin (HCQ) to induce an Immune Quiescence (IQ) phenotype, which has been previously associated with natural protection to HIV infection. This phenotype is characterized by lower expression of genes involved in cellular activation, lower resting levels of inflammatory cytokine production, lower level of systemic activated T cells, increased levels of systemic T regulatory, … |
KEITH FOWKE; | 2018-01-01 |
| 160 | Clinical Study Protocol for The Illumigene® Chlamydia and Illumigene® Gonorrhea DNA Amplification Assays PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the illumigene Chlamydia and illumigene Gonorrhea assays, using the illumipro-10, with male urine, female urine, physician-collected (medical professional) endocervical swabs and self-collected vaginal swabs taken from symptomatic and asymptomatic patient populations. |
MERIDIAN BIOSCIENCE | 2014-09-09 |
| 161 | A Comparative Evaluation of The Single-dose Efficacy of Oral Delafloxacin Versus The Single-dose Efficacy of An Intramuscular Injection of Ceftriaxone in Subjects With Uncomplicated Urogenital Gonorrhea PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the effects of a single oral dose of delafloxacin versus a single intramuscular injection of ceftriaxone in subjects with uncomplicated cervical, urethral, rectal, or pharyngeal gonorrhea. |
MELINTA THERAPEUTICS | 2014-12-10 |
| 162 | Prevalence of Gonorrhea and Chlamydia Infections in Multiple Anatomical Sites in HIV-infected Men Who Have Sex With Men at An HIV Clinic in Omaha, Nebraska PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Hypothesis: Men who have sex with men (MSM) are at higher risk for sexually transmitted diseases. Currently, free testing for sexually transmitted diseases is only being performed in urine samples. Investigators hypothesize that the rates of both gonorrhea and chlamydia will be higher when testing includes more than one anatomical site (rectum and oropharynx). The aim of the study is to estimate the rates of asymptomatic Chlamydia and/or Gonorrhea in the oropharynx, … |
URIEL SANDKOVSKY; | 2014-10-01 |
| 163 | The Pharmacokinetics of Extended Duration High-Dose Cefixime for The Decreased Susceptibility of Neisseria Gonorrhoeae: A Phase I Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a Phase I, open label, non-randomized, dose-frequency escalation pharmacokinetics study among 24 healthy male and female subjects, aged 18 to 45 years to determine the pharmacokinetics and safety of high-, multi-dose cefixime for the treatment of reduced susceptibility gonorrhea. Stage 1(Cohorts A and B) will examine the pharmacokinetics of single 400mg and 800mg dose of cefixime. Stage 2(Cohorts C and D) subjects will take 800mg of cefixime every 12 hours for 2 doses. If that dosing regimen is well tolerated, the dose-frequency will escalate to 800mg every 8 hours for 3 doses, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2015-12-01 |
| 164 | Reducing HIV/STD Risk in African American Women With At-Risk Male Partners PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The FemAALES Project is a community collaborative two-arm intervention designed to prevent HIV (human immunodeficiency) and STD (sexually transmitted disease) infection and transmission among African American women and men by reducing sexual risk factors and enhancing sexual negotiation skills. The team of investigators is a collaboration of researchers and community service providers who are committed to developing prevention interventions that employ holistic and culturally relevant approaches. This includes recognizing the impact of forces such as racism, sexism, and gender expectations on individual behavior and relationship dynamics in African American communities. Specifically, … |
NINA T HARAWA; | 2018-04-01 |
| 165 | Implementation of A Sexual Health Intervention for YMSM in Two Vietnamese Cities PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study seeks to implement a sexual health promotion intervention for male sex workers in Hanoi and Ho Chi Minh City, Vietnam. The study hypothesis is that this intervention will increase testing, treatment and vaccination for sexually transmitted infections, including intentions of participants to engage in these services beyond the conclusion of the intervention. At the community level, the study hypothesis is that male sex workers will be more aware of sexual health care and more likely to access these services in the future. |
NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES | 2016-09-01 |
| 166 | Efficacy of Internet-based HIV Prevention PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Young men who have sex with men (YMSM) account for almost 70% of HIV diagnoses among all young people in the U.S. and are alone in facing an increasing rate of infections. Because YMSM are less likely to receive relevant sexual health education in traditional settings (e.g. schools, community), the Internet is a unique route of reaching and helping YMSM. The purpose of this study is to compare two different versions of an online HIV prevention program for YMSM. The study is being conducted by researchers at Northwestern University in Chicago, Hunter College in New York City, … |
BRIAN MUSTANSKI; | 2017-03-01 |
| 167 | Prospective Collection of Female First-catch Urine, Vaginal Swab,Cervical, and Endocervical Swab Specimens for Testing With The APTIMA Assays PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to obtain female first-catch urine, vaginal, cervical and endocervical swabs for testing with multiple APTIMA Assays on the Gen-Probe PANTHER® and TIGRIS® Systems. |
GEN PROBE | 2014-07-01 |
| 168 | A Trial of Intravesical Therapy for Interstitial Cystitis in Patients With Generalized Vulvodynia Related Papers Related Patents Related Grants Related Experts Highlight: In order to investigate whether the pain in women with vulvodynia may represent bladder origin pain, we will be performing a diagnostic test for interstitial cystitis (IC) in women with generalized vulvodynia. Those women with a positive test for IC, we will be performing a series of bladder treatments (instillations) for IC and checking symptoms throughout the trial to see if significant relief of vulvar pain can be obtained through treatment for IC. |
BRUCE KAHN; | 2014-06-01 |
| 169 | An Integrated HIV Prevention Model for African American Mothers and Daughters PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study has three specific aims: 1. To conduct a 2-arm randomized controlled trial comparing IMARA to a family-based health program (FUELTM). The investigators will: a. Randomly assign 300 14-18 year-old AA or black girls and their primary female caregivers to IMARA (N=150) or FUELTM (N=150). Women and girls will be recruited four ways: 1) from mental health clinics using clinic liaisons, 2) flyers will be posted in clinic recruitment sites and other agencies instructing interested families to call our recruiter, 3) IMARA participants will hand flyers to interested women and girls they know, … |
GERI DONENBERG; | 2018-01-31 |
| 170 | Expedited Partner Therapy As STI Control Among MSM in Peru PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Expedited Partner Therapy (EPT) has been shown to reduce rates of persistent or recurrent gonorrhea and chlamydia infection in heterosexual patients, but has not been evaluated for use among men who have sex with men (MSM). CDC guidelines support the use of EPT for partner management with heterosexual patients, but note the absence of evidence necessary to make an equivalent recommendation for the use of EPT with MSM. Randomized clinical trials to assess the impact of EPT on partner notification, treatment, … |
JESSE CLARK; | 2014-08-01 |
| 171 | An Open-Label Study to Evaluate The Efficacy and Safety of A Single-Dose of Oral CEM-101 in The Treatment of Male and Female Patients With Uncomplicated Urogenital Gonorrhea PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To determine the safety and efficacy of a single dose of solithromycin (CEM-101) for the treatment of uncomplicated urogenital gonorrhea. |
EDWARD W HOOK; | 2013-06-01 |
| 172 | Repeat STI Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: People who present repeatedly at Sexually Transmitted Infection (STI) clinics represent a key population for HIV prevention intervention research. Despite their heightened risk there is an absence of empirical research on strategies to intervene with repeat STI. Some STI-clinic based behavioral HIV prevention studies, focusing on the general STI patient population, have found that risk reduction interventions can reduce the incidence of a subsequent STI. Studies have shown that expedited treatment for STI patients’ partners can reduce subsequent STI and enhancing partner notification can reduce risk for repeat infection. Those who go on to experience repeat infections, … |
LANCE WEINHARDT; | 2016-12-01 |
| 173 | HIV Prevention Intervention for Young Transgender Women PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to test the efficacy of a uniquely targeted HIV risk reduction intervention for young transgender women (YTW), ages 16 to 29, at risk for HIV acquisition or transmission. |
ROBERT GAROFALO; | 2016-10-01 |
| 174 | Prospective Collection of Female First-catch Urine, Vaginal Swab, Cervical, and Endocervical Swab Specimens and Male Urethral Swab and First-catch Urine Specimens for Testing With The PANTHER® System PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to obtain female first-catch urine, vaginal, cervical and endocervical swabs and male first-catch urine and urethral swabs for testing with multiple APTIMA Assays on the Gen-Probe PANTHER® System |
GEN PROBE | 2013-07-01 |
| 175 | EKISS Electronic KIOSK Intervention for Safer-Sex: A Pilot Randomized Controlled Trial of An Interactive Computer-based Intervention for Sexual Health in Adolescents and Young Adults PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a randomized controlled trial to test acceptability, feasibility and preliminary efficacy of an interactive computer-based intervention with individualized feedback to promote sexual health in adolescents and young adults with assessment of behavioral and biomarker outcomes. |
TARANEH SHAFII; | 2013-06-30 |
| 176 | Project AWARE: Using The ED to Prevent STIs in Youth Related Papers Related Patents Related Grants Related Experts Highlight: Project Aware introduces a sexually transmitted infection (STI) screening model for sexually experienced adolescents aged 14 to 21 in a large, inner-city Emergency Department (ED) in the Bronx, N.Y. Project Aware will scaffold routine, rapid testing and counseling for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) onto an existing, successful, ED-based HIV testing and counseling program, Project BRIEF. Project Aware will educate and motivate youth to use condoms with the aid of a theory-based, youth-friendly multimedia behavioral intervention proven to be effective during the investigator’s K23 training. Through Project Aware, … |
YVETTE CALDERON; | 2013-05-01 |
| 177 | Reducing The Risk of HIV/STD Infection Among African American Men PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: African American men have by far the highest rates of HIV in the US, but there are few randomized controlled trials (RCTs) of interventions to dissuade heterosexually active African American men from engaging sexual risk behavior. This research seeks to address this gap in the behavioral intervention literature. That self-initiated behavior change, as well as intervention-induced behavior change, is often short-lived, eroding over time, is widely known; accordingly, this research also seeks to test a strategy to sustain intervention efficacy. In a RCT, … |
JOHN B JEMMOTT III; | 2015-06-01 |
| 178 | Sexually Transmitted Infections Among African American Women Who Have Sex With Women PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine rates of sexually transmitted infections (STIs) among African American women who have sex with women (AAWSW). In addition, the study is interested in better understanding the types of risk behaviors that place AAWSW at risk for STIs. The investigators hypothesis is that AAWSW experience high rates of STIs, similar to heterosexual African American women. Knowledge gained from this study will guide development of interventions to reduce women’s risk for these types of infections and will improve how AAWSW are screened for STIs. |
CHRISTINA MUZNY; | 2013-10-01 |
| 179 | AMC-072: Protective Effect of Quadrivalent Vaccine in Young HIV-Positive Males Who Have Sex With Males PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: RATIONALE: Vaccines made from a gene-modified virus may help the body build an effective immune response to prevent viral infection. PURPOSE: This phase II trial is studying how well vaccine therapy works in preventing human papillomavirus (HPV) infection in young HIV-positive male patients who have sex with males. |
JOEL PALEFSKY; | 2017-12-12 |
| 180 | A Case Control Study of Women With Multiple Sexual Partners Attending The Jefferson County Department of Health Sexually Transmitted Diseases Clinic PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Both population based surveys and more focused research studies indicate that increased numbers of sexual partners and partner concurrency contribute to increased risk for acquisition of sexually transmitted infection (STI), including HIV infection. However, unlike for men, both national and sub-population-based studies consistently find that the great majority of women with or without STIs report only 1-2 sex partners in the preceding year and that a minority of women acknowledge > 3 sex partners over the same period, … |
CHRISTINA MUZNY; | 2013-11-01 |
| 181 | The Use of Computer-Assisted Self-Interviews to Improve Adolescent and Young Adult Health Screening in The Pediatric Emergency Department PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if an Audio-enhanced Computer-Assisted Self-Interview (ACASI) will lead to increase testing for sexually transmitted infections in youth visiting a pediatric ED |
FAHD A AHMAD; | 2012-03-01 |
| 182 | A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of The Dominican Republic (DR) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine the feasibility of introducing voluntary medical male circumcision as a form of HIV prevention in high HIV prevalence areas in the Dominican Republic. |
MAXIMO BRITO; | 2017-04-01 |
| 183 | A Multicenter, Open-Label, Non-Comparative Study of The Safety and Contraceptive Efficacy of The Woman’s Condom PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: WHAT IS THE FEMALE CONDOM? The female condom being examined in this study is investigational (experimental) and is not yet approved by the Food and Drug Administration (FDA). The female condom is made up of a pouch that adjusts to the shape of the vagina. The female condom that will be used in this study is not lubricated, but a water-based lubricant will be provided for you to use with it. Also, … |
PREMIER RESEARCH | 2026-02-09 |
| 184 | Safer Sex Intervention for Male Clients of Female Sex Workers in Tijuana, Mexico PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Behavioral interventions designed to reduce risk of HIV and sexually transmitted infections (STIs) have mostly failed to consider clients of female sex workers (FSWs), who may act as a bridge to the general population. This study proposes to test a brief, one-hour counseling intervention with male clients in Tijuana, Mexico, to reduce their rates of unprotected sex (i.e., … |
THOMAS L. PATTERSON; | 2015-02-01 |
| 185 | Randomized Trial of Home Versus Clinic-based Screening for Sexually Transmitted Infections in Long-Acting Reversible Contraceptive Users Related Papers Related Patents Related Grants Related Experts Highlight: This study randomizes women using long-acting reversible methods of contraception to home-based STD screening through the mail compared to screening available in a clinical setting. We hypothesize that women randomized to home-based screening will be more likely to complete screening. |
JEFFREY PEIPERT; | 2010-08-17 |
| 186 | Maternal Genitourinary Infections and Adverse Perinatal Outcomes in Sylhet District, Bangladesh PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim of this study is to determine the impact of community-based screening and treatment of abnormal vaginal flora and urinary tract infections in early pregnancy (13-19 weeks) on preterm live birth in Sylhet district, Bangladesh. Hypothesis 1: Community-based screening and treatment of abnormal vaginal flora (Nugent score >4) and urinary tract infections in early pregnancy (13-19 weeks) will reduce the population rate of preterm live birth by at least 15%. The secondary aims of this study are: – To determine the impact of community-based screening and treatment of abnormal vaginal flora and urinary tract infections on the: – … |
ABDULLAH H BAQUI; | 2015-05-01 |
| 187 | Alcohol, Marijuana, and Risky Sex: Group Interventions With Detained Adolescents PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This research is studying behaviors that young people engage in that may place them at risk for contracting a sexually transmitted disease like HIV/AIDS, and what kind of educational program works best to reduce these risky behaviors. |
UNIVERSITY OF NEW MEXICO | 2014-06-01 |
| 188 | Vaginal Cytokines in Postmenopausal Women With Symptoms of Vulvovaginal Irritation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Many postmenopausal women suffer from vaginal symptoms such as dryness, itching, and painful intercourse. The underlying pathology is unknown. Since symptoms are comparable to those found in infectious vaginitis during the reproductive life stage, the investigators hypothesize that the vaginal milieu in symptomatic postmenopausal women is comparable to inflammation in vaginitis. The investigators therefore study vaginal cytokines in symptomatic and asymptomatic postmenopausal women. |
PETRA STUTE; | 2012-12-01 |
| 189 | A Randomized Controlled Clinical Trial of An Internet-based Prevention Intervention to Reduce STI in High-risk HIV Infected MSM PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a CCTG sponsored trial in collaboration with UCSD-AVRC investigators to get more information about the methods that are used on the internet to provide information on how to reduce the risk of giving or getting infections that are often or usually passed from one person to another during sexual or intimate contact (sexually transmitted infection (STI)). STIs include chlamydia, … |
SHELDON MORRIS; | 2017-11-09 |
| 190 | Comparisons of Public Health Screening Methods for Acute and Early HIV Infection: Home Self-Testing for HIV Infection PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine whether the availability of home self-testing for HIV will increase HIV testing frequency among men who have sex with men without negatively impacting their risk for HIV acquisition. |
JOANNE STEKLER; | 2014-12-01 |
| 191 | PHAT Life: Preventing HIV/AIDS Among Teens in Juvenile Justice PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: PHAT Life: Preventing HIV/AIDS Among Teens, is a uniquely-tailored intervention designed for recently-arrested juvenile offenders on probation. The program will teach teens about HIV/AIDS, sexually transmitted infections, and safer decision-making. The PHAT Life Research Study is a 2-arm randomized controlled trial of the PHAT Life Intervention. The investigators will test and compare PHAT Life to the health promotion control group on adolescent risky sexual behavior, substance use, and theoretical mediators. |
GERI DONENBERG; | 2017-12-31 |
| 192 | Randomized Clinical Trial Evaluating The Efficacy of Gentamicin/Azithromycin and Gemifloxacin/Azithromycin Combination Therapies As An Alternative Regimen for Uncomplicated Urogenital Gonorrhea PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to learn how to better treat gonorrhea infections. Gonorrhea is a sexually transmitted disease (STD) that is usually cured with a single antibiotic. However, some gonorrhea is not cured with a single antibiotic. The study will look at how well treating gonorrhea with 2 antibiotics works. Participants will be assigned to 1 of 2 treatment groups each receiving a combination of 2 antibiotics. Sites in the United States will recruit 500 male and female participants. Participants must be 15 to 60 years old, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2013-05-01 |
| 193 | A Randomized Trial of Home Versus Clinic-Based STD Testing Among Men PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study randomizes St. Louis men to home-based STD screening or clinic-based STD screening. Home-based screening will be completed through the mail and clinic-based screening in a local clinical setting. We hypothesize that men randomized to home-based screening will be more likely to complete screening. |
JEFFREY PEIPERT; | 2011-12-01 |
| 194 | Project Aware: HIV Rapid Testing & Counseling in STD Clinics in The U.S. — An Adaptation of CTN 0032 PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Project Aware is a randomized controlled clinical trial in which individuals seeking medical or health services at sexually transmitted disease (STD) clinics are recruited to participate in a multi-center HIV testing and counseling study. The investigators will assess the relative effectiveness and cost-effectiveness of (1) on-site HIV rapid testing with brief, participant-tailored prevention counseling vs. (2) on-site HIV rapid testing with information only. The investigators will evaluate the effect of counseling on one primary outcome: STI incidence. Secondary outcomes will be reduction of sexual risk behaviors, substance use during sex (i.e., … |
LISA METSCH; | 2012-02-01 |
| 195 | Addressing Psychosocial Needs and HIV Risk in Indian MSM PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will develop and pilot test a combined individual and group-level behavioral HIV prevention intervention for men who have sex with men (MSM) in Chennai, India, addressing HIV risk within the context of broader psychosocial issues, including self-acceptance, substance use and social support. |
STEVEN A. SAFREN; | 2010-11-01 |
| 196 | A Double-Blind, Randomised, Placebo-Controlled Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess Delivery of Dapivirine From The Matrix Vaginal Ring Containing 25 MG of Dapivirine PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed study is a single center, double-blind placebo-controlled trial to assess the safety and tolerability of the dapivirine ring as compared to a placebo ring when inserted for 28 days in 16 healthy, HIV-negative women. |
INTERNATIONAL PARTNERSHIP FOR MICROBICIDES | 2010-04-01 |
| 197 | Time to Cure Chlamydia Trachomatis: Prospective Cohort Study on Detection of Chlamydial RNA and DNA in Anorectal and Cervicovaginal Infections During 8 Weeks After Directly Observed Treatment With Azithromycin PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objective was to understand the dynamics of Chlamydia trachomatis (Ct) detection by nucleic acid amplification testing (NAAT) after treatment and consequences for test-of-cure practice. |
MAASTRICHT UNIVERSITY MEDICAL CENTER | 2011-07-01 |
| 198 | A Validation Study of The Gen-Probe APTIMA Combo2 (AC2) for Detecting Chlamydia Trachomatis and Neisseria Gonorrhoeae in Rectal Samples PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Our hypothesis is that nucleic acid amplification testing (NAAT) with the APTIMA Combo2 (AC2) will have greater sensitivity than culture in detecting Neisseria gonorrhoeae in rectal samples. We also hypothesize that AC2 will be equivalent to NAAT with the Becton Dickinson ProbeTec in detecting Chlamydia trachomatis and Neisseria gonorrhoeae in rectal samples. |
SHARON HILLIER; | 2010-03-01 |
| 199 | Prevalence of Asymptomatic and Symptomatic Infection of N. Gonorrheae and C. Trachomatis and Seroprevalence of HSV Typ 2 and Sexual Health Seeking Behaviour in People With HIV Infection in Bern PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: There has been an increase in incidence in sexually transmitted infections in HIV infected patients in the last years. In this study the investigators will prospectively evaluate the prevalence of symptomatic and asymptomatic infections with N. gonorrhea and Ch. trachomatis as well as the seroprevalence of Herpes simplex Type 2 infection in HIV-infected patients attending the clinic for infectious diseases at the Berne University Hospital. In addition, participants will be asked to fill out a questionnaire on sexual behaviour and sexual health. Study hypothesis: STI prevalence is high in certain risk-groups to justify screening in regular intervals. |
HANSJAKOB FURRER; | 2010-06-01 |
| 200 | Adapting Project SAFE: Reducing STD/HIV Risk in Women Prisoners PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Project POWER will test the efficacy of a multi-session HIV Prevention program, adapted from an existing program (Project SAFE), for incarcerated women in the rural South. |
CATHERINE FOGEL; | 2012-12-01 |