Clinical Digest: Recent Clinical Trials on Heart Disease (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Heart Disease. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Heart Disease (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | The Effect of A Heart Health Awareness Program on Women’s Knowledge, Attitudes, and Practice Toward Cardiovascular Disease and Health Literacy: A Single-Blind Cluster Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to examine the effect of a gender-specific heart health protection awareness program, incorporating video-supported reminder messages, on knowledge, attitudes, practices (KAP) regarding cardiovascular diseases and health literacy among adult women aged 20 to 64 with no prior diagnosis of cardiovascular disease. The centers where the study is conducted will be divided into intervention (n=4) and control (n=5) groups using cluster randomization. While the intervention group receives a heart health awareness program consisting of three sessions in total, including education, risk factor screening, and individual counseling over a period of three weeks, … |
NURBANU ODACI; | 2026-03-31 |
| 2 | NUDGE-IHD: A Nationwide Pragmatic Randomized Trial of Electronic Nudges to Increase Patient Activation to Support Risk-factor Control in Ischemic Heart Disease PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether simple electronic information letters can increase patient activation and improve risk-factor monitoring in adults in Denmark with ischemic heart disease (IHD) who have LDL cholesterol above the recommended treatment target. A subgroup of participants with elevated lipoprotein(a) \[Lp(a)\] will also be randomized to receive an additional information letter. The main questions the study aims to answer are: * Does sending an electronic letter about elevated LDL cholesterol increase the proportion of patients who have at least one LDL-cholesterol test within 6 months? * Among patients with ischemic heart disease and elevated Lp(a), does receiving an information letter about Lp(a) increase patient activation, reflected by cardiometabolic risk-factor monitoring? Because this is a randomized trial, researchers will compare people who receive the electronic letter(s) with people who do not receive any letter to determine whether the letters encourage patients to take action, such as obtaining laboratory tests or contacting their doctor. Participants will: * Receive an electronic letter through Denmark’s national digital mailbox system (Digital Post) or receive no letter, depending on random assignment. * Continue their usual health care, with no additional visits, treatments, or procedures required for the study. * Have all study information collected from existing Danish nationwide health registries. |
TOR BIERING-SØRENSEN; | 2026-03-10 |
| 3 | Cobas® Lumira Collection of Venous and Capillary Blood Samples for The Research, Optimization and Calibration of New Diagnostic Devices (EVOLVE) PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a blood sample collection study, collecting venous and capillary blood samples from adult patients in the UK, with a range of health conditions. The purpose of this study is to collect blood samples to help develop, improve, and fine-tune new and existing diagnostic tests for the cobas® lumira instrument. This instrument is a diagnostic medical device with single-use test strips, that allows diagnostic testing right at the patient’s side. The aim is to improve doctors’ ability to monitor health conditions more quickly and easily. Approximately 30,000 patients are expected to participate in this study, … |
LUMIRADX UK | 2026-01-30 |
| 4 | A Pragmatic, Cluster-randomised Stepped-wedge Trial to Evaluate The Effectiveness of A New Cross-sectoral Form of Care (NVF) in Patients With New-onset Stable Chest Pain and Suspected Coronary Artery Disease (CAD) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: In Germany, coronary CT offers an accurate and less burdensome alternative to cardiac catheterisation for evaluating suspected coronary artery disease, but it is still underused. The IMPRO stepped-wedge trial tests a new, nationwide care model (NVF) in 16 regions to improve guideline-based intersectoral implementation of coronary CT and assess its impact on cardiovascular outcomes and healthcare costs. If effective, the model of care (NVF) could be adopted across Germany to enhance care quality while reducing unnecessary procedures and expenses. |
ANNIKA VINIOL; | 2026-03-17 |
| 5 | A Prospective, Multicenter, Randomized Controlled Trial on The Impact of Coronary CTA Combined With CT-FFR on Diagnosis and Treatment Decisions and Clinical Outcomes in Emergency Patients With Intermediate Risk Chest Pain PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the guiding value of coronary CTA combined with CT-FFR in diagnostic and treatment decision-making for emergency chest pain patients at moderate risk, as well as its impact on clinical outcomes. Through a prospective multicenter randomized controlled trial, this research compares the preventive effects of early application of this technology versus standard care on major adverse cardiovascular and cerebrovascular events (MACCE), with the goal of optimizing the diagnostic and treatment processes for emergency chest pain patients. |
CHUANBAO LI; | 2026-03-20 |
| 6 | Longitudinal Validation of CIRC Technologies PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI’s lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, … |
CHRISTOPHER NGUYEN; | 2026-03-23 |
| 7 | Prevention of Incident Heart Failure With A Telemedicine-based Integrated Care Model Among Older Atrial Fibrillation Patients in Rural China: The MIRACLE-AF-Prevention Cluster Randomized Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to prevent heart failure in older adults (aged 65-80 years) living in rural China who have atrial fibrillation but do not currently have heart failure. Because atrial fibrillation significantly increases the risk of developing heart failure , this cluster-randomized trial tests whether a telemedicine-supported, village doctor-led integrated care model can improve long-term cardiovascular health compared to standard care. Participants are assigned by their local village clinic to receive either conventional routine medical care or a digital-smart management program. The integrated program includes using wearable devices to monitor daily health, … |
MING CHU; | 2026-03-25 |
| 8 | Assessment of Adherence to Clinical Practice Guidelines in Patients With Dyslipidemia Using A Clinical Decision Support System PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: To validate the performance of the developed clinical decision support system (CDSS) for participants with lipid metabolism disorders based on a decision tree algorithm. Materials and Methods: A clinical decision support system for participants with lipid profile abnormalities will be developed using the Orbeon open-source online form creation platform based on current clinical guidelines. During the CDSS pilot implementation, … |
I M SECHENOV FIRST MOSCOW STATE MEDICAL UNIVERSITY | 2026-02-24 |
| 9 | A Randomized Placebo-procedure Controlled Trial of The Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System PULmonary Artery Denervation Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH) associated with left heart disease (LHD). This randomized control trial will compare the investigational device (The Enhancor System) to control (medical therapy.) Participants who will consist of patients with chronic heart failure (HF) who are receiving maximally tolerated guideline-directed medical therapy (GDMT) for left heart failure, are clinically stable, and who have been diagnosed with CpcPH by right heart catheterization (RHC), … |
GREGG W. STONE; | 2026-03-12 |
| 10 | The COMPETE-LM Trial: A Physician-initiated Randomized Clinical Trial (RCT) Comparing Conventional Provisional Stenting With Drug-coated Balloon-enhanced Provisional Stenting for The Treatment of Complex Left Main (LM) Coronary Artery Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Prospective, physician-initiated, multicenter, randomized, single-blind, controlled trial. Participants will be randomized (1:1) to a DCB-enhanced strategy (study group) or a conventional strategy (control group). The study aims to compare the clinical outcomes of conventional provisional stenting (Angiolite in the main branch, with optional side branch stenting if compromised) versus DCB enhanced provisional stenting (Angiolite in the main branch plus Essential Pro in the side branch) in patients with complex left main bifurcation stenosis indicated to receive non-urgent percutaneous coronary intervention (PCI). Target lesions, both main vessel and side branch, will be treated using iVascular devices, … |
GÁBOR TÓTH; | 2026-02-13 |
| 11 | CT-FFR-Guided Revascularization in Patients With Severe Aortic Stenosis: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Severe aortic stenosis (AS) is often accompanied by coronary artery disease (CAD). While coronary computed tomography angiography (CCTA) is routinely used before aortic valve replacement (AVR) to evaluate coronary anatomy, it lacks physiological assessment of myocardial ischemia. This prospective, single-center, … |
CHENGDE LIAO; | 2026-03-13 |
| 12 | MICRA-HYBRID Trial: A Randomized Controlled Trial of ‘Multivessel Minimally Invasive Coronary Bypass Grafting As HYBRID Revascularization Versus Conventional Off-Pump Coronary Artery Bypass Grafting’ PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD and LCx) plus PCI of the RCA versus conventional off-pump coronary artery bypass grafting (OPCAB) via median sternotomy in patients with three-vessel coronary artery disease. The primary goal is to evaluate whether multivessel-HCR provides superior 30-day textbook clinical outcomes (mortality, MI, stroke, re-exploration for bleeding, and other complications) while improving perioperative recovery and long-term cardiovascular outcomes. |
FERDI AKCA; | 2026-01-02 |
| 13 | A Prospective Randomized Controlled Study on The Timing of Endoscopy in Coronary Heart Disease Patients Taking Antiplatelet Drugs With Acute Non-variceal Upper Gastrointestinal Bleeding PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective randomized controlled trial (RCT) evaluating the optimal timing of endoscopy in patients with coronary heart disease who are taking antiplatelet drugs and present with acute non-variceal upper gastrointestinal bleeding. Eligible patients will be randomly assigned to one of two groups: an urgent endoscopy group (undergoing endoscopy within 12 hours of hospital admission) or an early endoscopy group (undergoing endoscopy between 12 and 24 hours after admission). All patients will receive standard medical treatment for upper gastrointestinal bleeding and antiplatelet management in accordance with current clinical guidelines. The primary outcome of this study is the incidence of major adverse cardiovascular events (MACE) within 30 days between the two groups. Secondary outcomes include further bleeding events, all-cause mortality, length of hospital stay, and the need for blood transfusion during the follow-up period. This research aims to generate evidence-based clinical guidance on the safest and most effective endoscopy timing for this high-risk patient population. |
CHEN XUE; | 2026-04-02 |
| 14 | Health Coaching for Patients With Cardiovascular Disease: A Mixed-Methods Evaluation of The Impact on Patient Outcomes and Provider Satisfaction and Acceptability PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: For patients discharged with a diagnosis of cardiovascular disease coronary artery disease resulting in myocardial infarction and/or congestive heart failure, this study will evaluate if the addition of 12 virtual health coaching sessions over the course of 16 weeks will improve physiological, psychological, and social health outcomes, prove acceptable and satisfactory for these patients with CVD, decrease CVD-related questions and concerns sent to the provider via MyChart, … |
BETH STEINBERG; | 2026-01-05 |
| 15 | Finding Links Between Hot FlASHes and CardioVascular Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if neurokinin-1/neurokinin-3 receptor antagonist elinzanetant improves blood vessel health in women with moderate to severe hot flashes. The main questions it aims to answer is does neurokinin-1/neurokinin-3 receptor antagonist elinzanetant improve blood vessel health? |
EMILY LAU; | 2026-02-12 |
| 16 | The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: While the Fontan operation improves survival for patients with a functional single ventricle, complications like heart failure remain prevalent during follow-up, causing frequent hospitalizations and reduced quality of life. Currently, there are no evidence-based heart failure therapies or guidelines for patients with Fontan palliation. There is growing interest in using sodium-glucose cotransporter 2 inhibitors (SGLT2i) to optimize cardiac conditions in this group. SGLT2i’s observed benefits relate to protective effects on cardiac energy metabolism, renal function, sympathetic activation, inflammation, oxidative stress, erythropoiesis, and vascular function. Therefore, … |
CHEUNG YIU FAI; | 2026-03-19 |
| 17 | High Cardiovascular Risk Intervention With Cardio-Oncology Consultation for Prostate Cancer Following Androgen Receptor Pathway Inhibitor (ARPI) Therapy (Heart-Safe) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In patients with prostate cancer (PC), cardiovascular disease (CVD) causes significant morbidity and is the second leading cause of death. Both pre-existing CVD and the use of androgen deprivation therapy (ADT)-a key cornerstone of treatment for men with locally advanced or metastatic PC1,2 contribute to increased CV risk. ADT has been associated with adverse metabolic effects, including increased central adiposity, elevated low-density lipoprotein (LDL) levels, impaired glycemic control, and arterial wall remodeling and endothelial dysfunction The data demonstrates that for most patients, … |
KATELYN ATKINS; | 2026-02-03 |
| 18 | Safety and Efficacy of Immunosuppressive CAR-DC Targeting FAP in The Treatment of Ischemia Cardiomyopathy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To study the safety and efficacy of fibroblast activation protein (FAP)-targeted autologus immunosuppressive chimeric antigen receptor-dendritic cell (CAR-DC) in the treatment of ischemic cardiomyopathy, aiming to provide a novel therapeutic strategy for the disease. |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2026-04-01 |
| 19 | Design and Application of A Home Care Mini-Program for Children With Congenital Heart Disease After Discharge: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single-blind, randomized controlled trial aimed at evaluating the effectiveness of a family-centered, WeChat-based home care mini-program for children after congenital heart disease (CHD) surgery. Given the chronic nature of post-operative CHD management and the significant stress placed on families, this study shifts from a deficit-based to a strengths-based perspective, guided by the Double ABC-X model. Children (≤12 years old) who have undergone CHD surgery and their primary caregivers will be recruited. Participants will be randomly assigned to either the intervention group, which uses the mini-program for health education, peer support, and physiological monitoring, or the control group, … |
RUIJIE YANGLAN; | 2026-02-04 |
| 20 | Efficacy of Nigella Sativa (Nisatol®) Supplementation in Women With Borderline Blood Pressure Values or A Non-Dipper Blood Pressure Phenotype: A Randomized Placebo-Controlled Study With Dietary Intervention Phase PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized placebo-controlled study evaluates the efficacy of Nigella sativa (Nisatol®) supplementation in women with borderline blood pressure values or a non-dipper blood pressure phenotype. The study aims to assess the effects of supplementation on blood pressure and resting heart rate in women presenting high-normal blood pressure values (≥130/85 mmHg) and/or a nocturnal non-dipper blood pressure pattern. Participants will be randomly assigned to receive either Nigella sativa (Nisatol®) or placebo for 12 weeks. After the treatment phase, … |
AMJAD KHAN; | 2026-03-27 |
| 21 | Telemedicine-based Integrated Management of Atrial Fibrillation and Heart Failure in Older Patients in Village Clinics: The MIRACLE-AF II Cluster Randomized Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this cluster-randomized clinical trial is to evaluate a telemedicine-based, village doctor-led integrated management program for older adults (aged 65-80 years) who have both atrial fibrillation (AF) and heart failure (HF) in rural clinics in China. It aims to answer whether the digitally-supported program improves heart failure prognosis, assessed by the MAGGIC score, at 12 months , and reduces the risk of composite endpoint events, such as cardiovascular death, stroke, or heart failure hospitalization, over 36 months compared to conventional routine care. In this study, … |
MING CHU; | 2026-03-25 |
| 22 | A Double-blind, Randomized, Placebo-controlled, Multi-center Study Evaluating The Safety, Tolerability, and Effect of Olpasiran on Coronary Artery Plaque Burden Assessed By Coronary Computed Tomography Angiography in Participants With Stable Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA). |
AMGEN | 2025-12-19 |
| 23 | Effect of Glucose Variability on Morbidity and Mortality in Diabetic Patients Admitted in Coronary Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study is to assess the effect of glycemic variability on morbidity and mortality in diabetic patient during admission in Coronary care unit in sohag university. |
MOHAMED IBRAHIM MOHAMED; | 2026-04-02 |
| 24 | Effects of Long Extensive Aerobic Interval Training Versus Long Extensive Continuous Training on Heart Rate-Power Decoupling in Patients With Ischemic Heart Disease: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a randomized, parallel-group clinical trial with assessor and statistical analyst blinding, conducted at a single center. Participants with stable ischemic heart disease enrolled in a cardiac rehabilitation program will be randomly allocated to one of two aerobic exercise interventions: long extensive continuous aerobic training (zone 2) or long extensive aerobic interval training (zone 3). Both groups will participate in supervised exercise sessions twice weekly for a period of 8 weeks, integrated into the standard cardiac rehabilitation program. Assessments will be performed at baseline, immediately after the intervention period (8 weeks), … |
ISIDRO FERNÁNDEZ LÓPEZ; | 2026-03-20 |
| 25 | The 10-Year Extended Follow-up of The Different Antiplatelet Strategies After Coronary Artery Bypass Grafting Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the very long-term effects of different antiplatelet strategies in patients who underwent coronary artery bypass grafting (CABG) and participated in the original DACAB trial. The main questions it aims to answer are: Does one year of treatment with ticagrelor plus aspirin (dual antiplatelet therapy) after CABG reduce the risk of major adverse cardiovascular events (MACE) over 10 years compared with aspirin alone or ticagrelor alone? What are the long-term safety outcomes, including major bleeding events, … |
ZHU YUNPENG; | 2026-03-18 |
| 26 | Assessing The Cardio-Cerebral Oxygenation Reserve in Heart Failure Patients Using Oxygen-Sensitive Magnetic Resonance Imaging Technology PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: At different stages of heart failure (HF), the cardiac and cerebral oxygen reserve exhibits varying degrees of decline due to chronic hypoxia and microvascular dysfunction caused by reduced cardiac output, leading to cognitive dysfunction. As a direct marker of microvascular function, early identification and intervention of cardiac and cerebral oxygen reserve are crucial to prevent irreversible damage to organs such as the heart and brain. However, there is currently no precise and effective method to quantify cardiac and cerebral oxygen reserve. Oxygen-sensitive magnetic resonance imaging (OS-MRI), as an emerging functional imaging technique, … |
YAN’AN AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIVERSITY | 2026-03-20 |
| 27 | A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted By PannaWire PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Atrial septal defect (ASD) is a common congenital heart disease, and percutaneous interventional therapy is the main and effective treatment. Traditional percutaneous closure procedures are performed under fluoroscopic guidance and require contrast agents. A retrospective analysis of over 20,000 adult patients with congenital heart disease revealed that even low-dose radiation exposure was significantly associated with an increased long-term risk of malignancy. Moreover, the use of contrast agents carries the risk of allergic reactions and kidney injury. Radiation and contrast agents not only pose iatrogenic harm to patients but also limit the use of interventional techniques in special populations, … |
PAN XIANGBIN; | 2026-03-17 |
| 28 | A Randomized, Double-Blind Clinical Trial of Chaigui Longmu Ejiao Paste in The Treatment of Ischemic Heart Disease With Internal and External Controls PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study explores whether Chaigui Longmu Ejiao Paste can reduce the average weekly number of angina attacks in patients with ischemic heart disease after 8 weeks of treatment, using Chaigui Longmu Paste without Ejiao as a parallel control and incorporating a synthesized external control. |
SUYUN YUAN; | 2026-03-17 |
| 29 | Risk Stratification of MACE Based on GDF-15 in Heart Failure Patients Who Undergoing Coronary Artery Bypass Grafting: An Observational Multicenter Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: PROFILE-HF is a multicenter, observational, prospective study of the clinical course and outcomes of chronic heart failure (HF) and coronary artery disease (CAD) in patients undergoing coronary artery bypass grafting (CABG). The objective of the study is to develop a method for assessing the risk of adverse cardiovascular events in patients with CAD and HF who have undergone CABG, based on preoperative GDF-15 concentrations. The study will have a 12-month follow-up period; one in-person visit is planned at the end of the follow-up period. If it is not possible to visit a doctor in person, … |
ELENA A. KUZHELEVA; | 2026-03-18 |
| 30 | A Theory-Informed, Brief Patient Activation and Motivational Interviewing Approach to Implementing Depression Treatment in Cardiac Patients: A Quality Improvement Initiative PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study, which is being conducted as part of a Quality Improvement (QI) Initiative at Columbia University Irving Medical Center, will test whether delivering the iHeart DepCare tool increases real world reach and adoption of depression treatment among CHD patients. As part of the QI Initiative, Clinic Navigators will administer and record (in EPIC) depression screening in advance of primary care and cardiology appointments. Eligible patients with elevated depressive symptoms will be randomized to receive usual care vs. the iHeart DepCare tool in conjunction with brief motivational, … |
NATHALIE MOISE; | 2026-03-06 |
| 31 | CARAMEL: Retrospective Study for Personalized Risk Assessment of Cardiovascular Disease in Menopausal and Perimenopausal Women Using Real World Data PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: This retrospective observational study, part of the EU-funded CARAMEL project, aims to develop and validate personalized cardiovascular disease (CVD) risk assessment models specifically designed for menopausal and perimenopausal women (ages 40-60). The study leverages Real World Data (RWD) collected from multiple international clinical partners, including electronic health records (EHR), diagnostic imaging data, and signal data. The main objective is to improve the prediction of CVD precursors such as hypertension and dyslipidemia, as well as mid- and long-term risk of CVD events, through advanced artificial intelligence (AI) models. These models will be trained on multimodal data to capture complex, … |
LUIS GABRIEL LUQUE ROMERO; | 2026-01-15 |
| 32 | A Coronary Computed Tomography Angiography-guided Intensive Intervention for Population at High Risk for Cardiovascular Disease in Rural China: A Cluster Randomized Controlled Trial PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The CARDIAC trial is a prospective, parallel, open-label cluster randomized trial that aims to determine the effectiveness of a coronary computed tomography angiography (CTA)-guided intensive intervention strategy, as compared with standard care, on reducing the incidence of major adverse events (MACE) at 18 months among high-risk cardiovascular populations in rural China. An extended observational follow-up at 36 months will be conducted to further evaluate the effect on long-term clinical outcomes. |
YU BO; | 2026-02-18 |
| 33 | Prospective Multicenter Validation of A Home-Based Artificial Intelligence Enabled Single-Lead Electrocardiogram for Detecting Low Ejection Fraction and Structural Heart Disease PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective multicenter observational study will validate the accuracy of a previously developed artificial intelligence-enabled single-lead electrocardiogram (AI-ECG) model for identifying low ejection fraction and other structural heart disease phenotypes. Adult participants receiving a model-compatible single-lead electrocardiogram (ECG) (Apple Watch and QOCA ECG102D) and transthoracic echocardiography at five hospitals in Taiwan will be enrolled between March 1, 2026 and June 30, 2026. Model predictions will be compared with echocardiographic reference standards obtained within 30 days after the index ECG. |
CHIN LIN; | 2026-03-25 |
| 34 | Cardiovascular Assesment Under Current Hormone Replacement Therapy in Menopause (CATCH-Menopause) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women. Menopause-related estrogen deficiency leads to metabolic and vascular changes that increase atherosclerosis and cardiovascular events. This study hypothesizes that new HRT forms may reduce cardiovascular risk in high-risk women. |
LISA DANNENBERG; | 2026-02-10 |
| 35 | Artificial-Intelligence Assisted Opportunistic Screening for Valvular Heart Disease Using Non-contrast Chest CT Scans: A Prospective, Multicenter Study PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, multicenter study designed to develop and validate a deep learning model for screening valvular heart diseases using routine, non-contrast chest computed tomography (CT) scans. The primary objective is to evaluate the model’s diagnostic performance, with the sensitivity serving as the primary efficacy endpoint. Secondary endpoints will include other performance metrics such as area under the receiver operating characteristic curve (AUC), specificity, and accuracy, etc. |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2026-03-30 |
| 36 | Artificial Intelligence-Driven Angiography-Based Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients with coronary artery disease. |
JOO MYUNG LEE; | 2026-02-12 |
| 37 | Screening for Cardiac and Cardiac-associated Pathology Using Single-channel Electrocardiogram Analyzed With Machine Learning Models PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 4000 patients 18 years old and older in the training sample and 1000 patients over 18 years old in the test sample (the total number of patients is at least 5000 people). Patients will be included in the study if they have undergone a full examination (laboratory, clinical and instrumental), allowing for the verification or exclusion of cardiac and cardiac-associated pathology in accordance with current recommendations. During the course of the study, … |
I M SECHENOV FIRST MOSCOW STATE MEDICAL UNIVERSITY | 2026-02-09 |
| 38 | Computed Tomography-derived Fractional Flow Reserve Vs. Angiographic Quantitative Flow Ratio in Management of Patients With Coronary Artery Disease PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multi-center, randomized controlled trial to compare the clinical outcomes between CT-derived fractional flow reserve (CT-FFR) guided strategy and angiography-derived quantitative flow ratio (QFR) guided strategy among patients with coronary artery disease (CAD). Participants who have at least one coronary stenosis of 70%-90% (vessel diameter ≥2.5 mm) detected by coronary CT angiography will be enrolled and are randomly assigned in a 1:1 ratio to CT-FFR guided group or QFR guided group. In CT-FFR group, the decisions of invasive angiography and revascularization will be guided by CT-FFR. In QFR group, … |
CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES | 2026-02-12 |
| 39 | Surgical Measurement for Accurate Revascularization Using Transit-time FLOW (SMARTFLOW):Patency PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to learn more about a tool called Transit-Time Flow Measurement (TTFM). TTFM uses sound waves during surgery to check how well blood is flowing through blood vessels. This helps doctors see if the blood flow is good during coronary artery bypass grafting (CABG), which is a type of heart surgery |
MARIO GAUDINO; | 2026-03-20 |
| 40 | Using Cardiovascular Magnetic Resonance Identified Fibrosis to Assess Sudden Cardiac Death Risk in Patients With Non-ischemic Dilated Cardiomyopathy and The Unknown Therapeutic Risk Reduction of Contemporary Heart Failure Medication and Implantable Cardioverter-Defibrillators PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Research questions: The value of primary prevention implantable cardioverter-defibrillator implantation (ICD) therapy in patients with non-ischemic cardiomyopathy (NICM) is under debate. Improved risk stratification is needed to select patients at highest risk. Hypotheses: 1. In NICM patients with CMR detected myocardial fibrosis, … |
UNIVERSITY MEDICAL CENTER GRONINGEN | 2026-02-17 |
| 41 | Large Language Model-Generated Messages to Improve Guideline-Directed Medical Therapy in Heart Failure PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study is an investigator-initiated, cluster-randomized implementation trial evaluating a large language model (LLM)-based clinical decision support (CDS) tool designed to improve guideline-directed medical therapy (GDMT) for adult patients with heart failure seen in outpatient cardiology clinics at Mass General Brigham. For eligible heart failure encounters, the CDS tool reviews existing electronic health record (EHR) data, including diagnoses, medications, vital signs, laboratory results, and recent notes, and generates brief, … |
JONATHAN CUNNINGHAM MD MPH; | 2026-01-13 |
| 42 | Precision Risk Prediction of Symptom Clusters and Frailty With AI-Guided Emotion Detection: A Three-Year Study in Adults With Congenital Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this three-year mixed-methods observational study with an embedded randomized controlled trial is to develop and validate a frailty risk prediction model and evaluate an artificial intelligence-based voice emotion detection-guided counselling intervention in adults with congenital heart disease (ACHD). The main questions it aims to answer are: Are symptom clusters associated with frailty and psychological outcomes in adults with congenital heart disease? Can symptom clusters and psychosocial factors be used to predict frailty risk over time in ACHD patients? Does an AI-based voice emotion detection-guided counselling intervention improve psychological outcomes, fatigue, … |
YU-SHIU LIU; | 2026-03-18 |
| 43 | Effects of Functional Bovine Milk Supplementation on Coronary In-Stent Restenosis and Major Adverse Cardiovascular Events in STEMI Patients Undergoing Primary PCI: A Randomized, Double-Blind, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized, double-blind, controlled clinical trial will evaluate the effects of daily supplementation with functionalized bovine milk, enriched with bioactive peptides and optimized lipid profile, on coronary in-stent restenosis and major adverse cardiovascular events (MACE) in patients with first ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) and drug-eluting stent (DES) implantation. Participants will be randomly assigned to receive either functionalized milk or an isocaloric non-functional milk for 12 months, in addition to standard secondary prevention care. The primary endpoint is the incidence of in-stent restenosis at 12 months, … |
RAFFAELE MARFELLA; | 2026-01-21 |
| 44 | Assessment of Growth in Children With Congenital Heart Disease in Assuit University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Children with congenital heart disease (CHD) often experience growth problems. This study aims to assess and compare the growth (weight, height, head circumference) of infants and children with CHD against the expected growth standards for healthy children. This is a retrospective study that will review the medical records of children aged 1 month to 2 years who were diagnosed with CHD at Assiut University Children Hospital. The study will help understand how different types of CHD affect a child’s growth, which is important for improving their nutritional care and overall management. |
LAMIA MOHAMMED HUSSAIN MOHAMMED; | 2026-01-28 |
| 45 | Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes (CAAD-PVC): A Randomised Controlled Trial Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Premature ventricular complexes (PVCs) are extra, abnormal heart beats arising from the ventricles of the heart and are the most common ventricular arrhythmia. PVCs can be treated with medication or with a procedure called catheter ablation. It is not known which provides a better cure or provides better quality of life. The purpose of this research project is to study the best way to treat PVCs by comparing the use of medication to catheter ablation to assess which approach is better at reducing symptoms and improving quality of life. |
SAURABH KUMAR; | 2026-03-03 |
| 46 | Assessment of The Effects of SGLT2 Inhibitors on Pericoronary Fat in Non-diabetic ACS Patients Without Heart Failure Using CCTA PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if dapagliflozin, a sodium-glucose cotransporter 2 inhibitor (SGLT2i), can reduce coronary artery inflammation in people with acute coronary syndrome (ACS) who do not have diabetes or heart failure. Coronary inflammation will be measured using the fat attenuation index (FAI), … |
HAN YALING; | 2026-01-20 |
| 47 | AcceleRating The Translation of Virtual Twins Towards A PErsonalised Management of Steatotic Liver Patients PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to create a detailed virtual model to better understand how Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) develops. This model will also help predict heart problem at different stage of the disease. |
HOSPITAL UNIVERSITARI VALL D’HEBRON RESEARCH INSTITUTE | 2026-02-24 |
| 48 | Performance of An OCR-Prompt-LLM Integrated Workflow for Extracting Multi-dimensional Clinical Data in Ischemic Heart Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This research aims to evaluate a comprehensive AI-driven workflow for both clinical data extraction and diagnostic classification in coronary artery disease (CAD). Leveraging OCR and Large Language Models (LLMs), the system is designed to extract ten key clinical parameters (such as LVEF and lab results) and provide diagnostic subtypes (UA, STEMI, NSTEMI, CCS) directly from unstructured inpatient records. A man-machine comparative trial will be conducted using a test set of 308 patients, … |
CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES | 2026-03-30 |
| 49 | The Effectiveness of A Theory-driven Behavioral Change Intervention on Sedentary Behavior in Individuals With Coronary Heart Disease: A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this randomised controlled trial is to examine the effectiveness of a theory-driven behavioural change intervention on total sedentary time (primary outcomes), moderate-to-vigorous physical activity time, intention of behavioural change, future time perception, behavioural prepotency, self-regulation capacity, and exercise capacity in individuals with coronary heart disease. Hypotheses: Compared to the participants in the control group, participants in the intervention group will demonstrate: 1. Significantly less total sedentary time 2. Significantly improved MVPA time, 3. Significantly better intention of behavioural change, 4. Significantly higher level of behavioural prepotency, 5. Significantly enhanced self-regulation capacity, … |
ELAINE YI NING MIU; | 2026-01-22 |
| 50 | Effect of Non-Surgical Periodontal Therapy on Ischemia-Modified Albumin and Soluble ST2 in Patients With Stable Angina PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical study is to learn whether gum treatment can improve heart health. Researchers will compare blood markers related to heart disease before and after routine gum treatment. The main questions this study aims to answer are: Is gum disease a risk factor for heart disease? Can treating gum disease lower the risk of heart disease? Adults with stable angina (a type of heart disease) and adults without heart disease may take part in this study. All participants will receive routine, non-surgical gum treatment, … |
SENA ALTINTAS; | 2026-02-17 |
| 51 | Inorganic Nitrates in Pulmonary Embolism With Hemodynamic Instability PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Pulmonary embolism (PE) is a serious condition caused by blood clots blocking the blood vessels in the lungs. In some patients, PE leads to increased pressure in the lung circulation and strain on the right side of the heart. Patients with intermediate high-risk PE have signs of right heart stress and heart muscle injury and are at risk of clinical deterioration despite standard treatment with anticoagulation. In addition to the mechanical obstruction caused by blood clots, … |
JACOB HOLLENBERG; | 2026-02-24 |
| 52 | Prospective, Randomized Open Label Trial of Telemedically Assisted Optimization for Heart Failure Patients Before Cardiac Surgery to Improve Perioperative Outcome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Patients with heart failure undergoing cardiac surgery face a significantly increased perioperative risk, yet no standardized strategy exists to mitigate this risk effectively. Current preoperative management relies on optimization of medical therapy without a structured prehabilitation approach. Given the strong association between eleveated preoperative N-terminal pro-B-type natriuretic peptide levels and postoperative outcomes, patients at increased risk could be identified using this biomarker. Telemedical disease management programs have demonstrated efficacy in outpatient heart failure care, but their role in preoperative optimization remains underexplored. This study aims to assess whether a structured, multidisciplinary, telemedicine-assisted prehabilitation program can reduce perioperative complications, … |
CAN GOLLMANN-TEPEKÖYLÜ; | 2026-02-18 |
| 53 | Deep Learning for Echo Analysis, Tracking, and Evaluation Prospective Evaluation (DELINEATE-Prospective) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Heart disease is the leading cause of death in the United States, and echocardiography (or echo) is the most common way doctors look at the heart. Echo is safe, painless, and can detect major heart problems, including weak heart pumping and valve disease. Valve disease, especially aortic stenosis (narrowing) and mitral regurgitation (leakage), is common in older adults but often goes undiagnosed. While echo is the main tool for finding valve problems, it takes time, requires expert training, and results can vary between readers. Recent advances in artificial intelligence (AI), especially deep learning (DL), … |
PIERRE ELIAS; | 2026-01-07 |
| 54 | Discontinuation of Antiplatelet Therapy After Drug-Coated Balloon Treatment PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the benefits and risks of discontinuing antiplatelet therapy on clinical outcomes in patients who previously underwent coronary intervention using a drug-coated balloon. The main questions it aims to answer are: Does stopping antiplatelet therapy after 12 months affect the risk of net adverse clinical events? Does stopping antiplatelet therapy reduce the risk of bleeding compared with continuing treatment? Researchers will compare patients who discontinue antiplatelet therapy with patients who continue antiplatelet therapy to determine the impact on clinical outcomes during follow-up. Participants will: Be randomly assigned to either discontinue or continue antiplatelet therapy Receive routine clinical follow-up through clinic visits or telephone contacts Be monitored for cardiovascular events and bleeding outcomes over time |
EUN-SEOK SHIN; | 2026-02-09 |
| 55 | Study of Lesion-Specific Invasive Haemodynamic Angina Thresholds PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: ORBITA-SOLAR is an invasive physiological cardiac catheterisation study that aims to determine whether different coronary stenoses have different angina thresholds. The angina threshold is defined as the amount of coronary flow reduction required to reproduce symptoms. Sixty patients with symptoms of stable angina and 2 coronary artery stenoses amenable to percutaneous coronary intervention (PCI) will be recruited. This study will use intra-coronary balloon inflation during supine exercise on an ergometer to measure the fractional flow reserve (FFR) and non-hyperemic pressure ratio (NHPR) that relates to angina onset, in real time, at the location of each stenosis. |
IMPERIAL COLLEGE LONDON | 2026-02-18 |
| 56 | The UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to develop a large, deeply characterised cohort that will be a platform for collaborative clinical and translational research into cardiovascular (CV) disease (CVD) and Immune-mediated-inflammatory-diseases (IMID). The main aim is to evaluate whether existing blood cardiac biomarkers predict adverse cardiovascular outcomes. The study will capture standard of care CV and associated health data (clinical, biochemistry/pathology and investigations) in patients across the IMIDs. Optional biological and/or imaging sub-studies will provide additional data and/or samples for associated analyses. |
MAYA H. BUCH; | 2026-02-06 |
| 57 | Stratification of Arrhythmic Risk And/or Heart Failure Risk in Patients With Hereditary Heart Disease PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Sudden cardiac death (SCD) is one of the leading causes of death in developed countries. These deaths (more than 5,000 per year in France) are due to hereditary arrhythmias or cardiomyopathies. Early diagnosis of SCD is often achieved through family screening, but the main challenge is to stratify the risk of SCD in these patients. Indeed, … |
NANTES UNIVERSITY HOSPITAL | 2026-03-27 |
| 58 | Observational Retrospective Study on Incidence, First-line Treatment Patterns, and Clinical Outcomes in Transfusion-dependent Lower-risk Myelodysplastic Syndromes in Spain Using The BIG-PAC® Database PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to understand the incidence of transfusion dependent lower-risk myelodysplastic syndromes (TD LR-MDS) and describing real-world first-line treatment patterns, healthcare resource utilization, and associated clinical outcomes in adult patients with TD LR-MDS in Spain |
BRISTOL MYERS SQUIBB | 2026-03-11 |
| 59 | Clinical Study on An Artificial Intelligence-Assisted Chest Radiograph Model Based on Big Data and Deep Learning for Early Detection of Kawasaki Disease PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to develop an AI-based early warning system for Kawasaki Disease (KD) using chest X-rays (CXR) in children diagnosed with Kawasaki Disease. The main question\[s\] it aims to answer are: 1. Can AI modeling of CXR features help identify high-risk KD patients earlier than current diagnostic methods? 2. Can the AI system predict the optimal IVIG treatment window and coronary artery risks in KD patients? Participants will: Provide retrospective data on chest X-rays and clinical data (CRP, coronary ultrasound, … |
XINHUA HOSPITAL SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE | 2026-02-12 |
| 60 | A Clinical Cohort Registry Study on Primary PCI for Acute Myocardial Infarction at Zhongshan Hospital PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a registry-based cohort investigation, prospectively enrolling patients who were diagnosed with acute myocardial infarction and underwent primary percutaneous coronary intervention (PCI) at Zhongshan Hospital, Fudan University, between January 1, 2009, and December 31, 2028. Baseline clinical characteristics, procedural details, laboratory results, and medication records will be systematically collected and documented. The clinical follow-up will encompass both in-hospital monitoring and post-discharge surveillance extending up to two years after the procedure. |
CHUNFENG DAI; | 2026-02-11 |
| 61 | Multimodal Clinical Data Integration and Artificial Intelligence Modeling for Predicting Complications Following Pediatric Transcatheter Closure of Perimembranous Ventricular Septal Defect PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to develop and validate a multimodal artificial intelligence prediction model for treatment-related complications in children with perimembranous ventricular septal defect (pmVSD) undergoing transcatheter device closure. The main question it aims to answer is: Can an AI model that integrates demographics, laboratory results, electronic health record text, echocardiography reports, chest radiographs, … |
KUN SUN; | 2026-01-29 |
| 62 | China Atrial Fibrillation With Complex Metabolic Disorders Cohort Study (CAME Cohort) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The number of atrial fibrillation (AF) patients in China is approximately 32.76 million, with a prevalence rate of 2.3%. AF is associated with severe outcomes such as stroke and heart failure. Metabolic disorders (e.g., obesity, diabetes mellitus, dyslipidemia) are closely linked to the onset and prognosis of AF. However, the epidemiological characteristics and disease burden of AF combined with metabolic disorders in China remain unclear. Additionally, the impact of complex multi-dimensional metabolic disorders on AF prognosis requires further investigation, and current clinical guidelines lack targeted management recommendations for this population. |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2025-12-30 |
| 63 | Optimal ATP Settings in The VT Zone for New Implantable Cardioverter Defibrillator (ICD) Implantation (DAN-ATP) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This is a pragmatic, two-group, cluster randomized trial designed to compare strategies for the Anti Tachycardia Pacing (ATP)-setting in the ventricular tachyarrhythmias (VT) zone when implanting a new implantable cardioverter defibrillator (ICD) in patients with heart disease in hospitals in Denmark. The strategies are: Burst or Ramp after 1. ATP (which is always burst) in VT zone. VT zone is defined between 180-249 (up to 269 in special cases) heartbeats per minute. The ICD will give either: Burst: The ICD is programmed to give ATP with 4 bursts. Or Ramp: The ICD is programmed to give ATP with 1 burst and 3 ramps. The participating hospitals will be assigned to one of two intervention strategies for periods of 4-months. The given intervention will follow the patient/ICD throughout the life time of the ICD, but with the possibility to reprogram at any time (intention to treat). It is calculated that the study needs a total of 398 events (second to fourth ATP), which is estimated to require 3980 implanted ICDs. The participants will be followed until the end of the ICD life, which is estimated to be around 10 years. |
BO GREGERS WINKEL; | 2026-01-27 |
| 64 | A Non-Inferiority Trial of Stopping Penicillin in Early Rheumatic Heart Disease: GOAL-Stop PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: GOAL-Stop is a randomized, controlled, non-inferiority trial designed to evaluate whether discontinuing secondary antibiotic prophylaxis (SAP) is non-inferior to continuing SAP in preventing progression of rheumatic heart disease (RHD) among children and adolescents. The trial will enroll participants aged 5-20 years with previously diagnosed mild RHD who have received at least 2 years of SAP and who demonstrate either echocardiographic normalization or stability (persistent mild RHD). Participants will be randomized to either continue SAP or discontinue SAP for 2 years. The primary outcome is echocardiographic progression of RHD at 2 years, … |
CHILDREN’S HOSPITAL MEDICAL CENTER CINCINNATI | 2025-12-18 |
| 65 | The Intravenous Amino Acid Therapy for Vascular Rigidity in End Stage Renal Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to learn if giving amino acids through the dialysis machine can help protect the blood vessels and heart in people with kidney failure. Patients on dialysis often have problems with stiff blood vessels, which increases their risk of heart attacks, strokes, … |
HAUKELAND UNIVERSITY HOSPITAL | 2026-02-06 |
| 66 | Genetic Hallmarks of Patients With Congenital Portosystemic Shunts and Portopulmonary Hypertension PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Congenital portosystemic shunt (CPSS) are rare vascular malformations causing blood from the intestines to bypass the liver and directly flow into body’s general circulation. Such liver bypass can cause several health problems, … |
VALÉRIE MC LIN; | 2026-01-20 |
| 67 | INtensive LiPid-lowering Therapy for Acute High-risk IntracRanial or Extracranial AtheroSclerosis -II (INSPIRES-2)：A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The research team is conducting a randomized, double-blind, placebo-controlled, multicenter clinical study aimed at evaluating the impact of adding Tolecilimab (a PCSK9 inhibitor) to standard lipid-lowering therapy (statins ± ezetimibe) on serum lipoprotein(a) \[Lp(a)\] levels and the risk of stroke recurrence within 90 days in patients with ischemic stroke or high-risk TIA (ABCD² ≥ 4) accompanied by elevated lipoprotein(a) levels (≥50 mg/dL). |
YILONG WANG; | 2026-01-15 |
| 68 | Smartphone-Based Use of Phonocardiography for Detection of Congenital Heart Disease: Diagnostic Performance Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims to assess the performance of the software called ausculto™. ausculto™ is a collection of computer algorithms that intend to analyse heart sounds recorded from the built-in microphone of a smartphone for abnormal sounds. Participants will have their heart sounds recorded during their normal attendance at the hospitals after consenting to participate in this study. Researchers will manually annotate the recorded heart sounds to create a database for use in future training and testing of artificial intelligence (AI) intended for medical uses. |
WONG CHUN KA; | 2026-01-29 |
| 69 | Comparative Study on The Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects in Patients Chronic Kidney Disease With Cardiovascular Disease /Heart Failure PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, investigators will compare the effect of vicadrostat combined with empagliflozin with the effect of spironolactone combined with empagliflozin on renal function and changes in protein profiles in blood and urine. The hypothesis is that the renal and cardiac responses between vicadrostat and spironolactone differ due to mechanistic differences in their mode of action. Spironolactone is a mineralocorticoid receptor antagonist (MRA) and exerts its effect on a receptor, or a type of receiver, found on various cells. Vicadrostat is an aldosterone synthase inhibitor (ASI) and inhibits aldosterone production. Therefore, both drugs affect aldosterone. However, … |
DAVID SMEIJERS; | 2025-12-26 |
| 70 | Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease. The study evaluates differences in survival, major cardiovascular events, and quality of life over 4 years, and contributes to the international STICH 3.0 collaboration assessing long-term outcomes. |
ERIK LIPSIC; | 2025-12-08 |
| 71 | Health Care By Food Planning Grant PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to learn whether combining healthy food access with personalized tools can help families improve heart health and make lasting lifestyle changes. The main questions the study aims to answer are: * Do the new tools (PRO-CVH and Triple-C) help families improve their heart health? * Which combination of tools and supports works best for families with limited access to healthy food? * Is this type of program easy to carry out and acceptable to families and healthcare teams? Families in the study will include one parent with a BMI greater than 30 who has Medicaid insurance and their child aged 6 to 11 years. Depending on which group they are assigned to, families may: * Receive food and nutrition education via handouts and/or online curriculum * Have access to an online health assessment tool than can help you understand your/your child’s risk factors for heart disease * Work with a personalized health coach who can help you set goals for healthier living online/virtually. * Receive medically tailored groceries and cooking classes. Researchers will follow participants for several months to see how their heart health changes and which parts of the program work best together. The information from this study will help design a larger clinical trial to test a practical, cost-effective program that can help families build healthier habits and reduce their risk of heart disease. |
AMRIK SINGH KHALSA; | 2026-02-02 |
| 72 | Non-Invasive Electrocardiographic Imaging for Personalized Arrhythmia Care in Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To assess the accuracy and clinical utility of a novel non-invasive ECGI mapping system in identifying arrhythmogenic regions of interest in patients with congenital heart disease. |
FUNDACION PARA LA INNOVACION EN BIOMEDICINA FIBMED | 2026-02-20 |
| 73 | Percutaneous Coronary Intervention With Guideline-Directed Medical Therapy Versus Guideline-Directed Medical Therapy Alone for Patients With Ischemic Cardiomyopathy and Reduced Left Ventricular Ejection Fraction: A Randomized, Controlled, Open-Label, Multicenter PCI-GULF Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate whether percutaneous coronary intervention (PCI) with contemporary drug-eluting stents (DES) combined with guideline-directed medical therapy (GDMT), compared to GDMT alone, reduces the time to first occurrence of major adverse cardiovascular events (MACE) through 12 months in patients with ischemic cardiomyopathy and a left-ventricular ejection fraction (LVEF) ≤40%. MACE is a composite of cardiovascular \[CV\] death, spontaneous myocardial infarction (MI), any unplanned revascularization, heart failure (HF)-related rehospitalization, heart transplantation, requirement of device implantation (e.g., valvular treatment, pacemaker, or left ventricular assist device \[LVAD\]), or requirement of intravenous medications due to worsening heart failure in outpatients. |
SHAO-LIANG CHEN; | 2026-01-21 |
| 74 | Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Several drugs have been shown effective in the treatment of obesity, with concomitant favourable cardiovascular effects. Today, there are no studies on novel anti-obesity drugs in patients with adult congenital heart disease (ACHD). Therefore, the investigators aim to study the effects of the anti-obesity drug tirzepatide (Munjaro) on cardiovascular and metabolic factors in obese patients with ACHD. In a 24-week, randomized, open-label, … |
KATJA PROKSELJ; | 2026-01-21 |
| 75 | Strategic Comparison Of Ischemia-based Versus Plaque Burden and VulnErability-based Revascularization in High-Risk Coronary Artery Disease Patients PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: 1. Study Purpose This study aims to compare clinical outcomes between two revascularization strategies in patients with high-risk coronary artery disease and 50-90% angiographic stenosis: a plaque burden and vulnerability-based revascularization strategy guided by intravascular imaging versus an ischemia-based revascularization strategy guided by physiologic assessment. 2. Background Percutaneous coronary intervention (PCI), in conjunction with optimal medical therapy, is one of the main therapeutic strategies for improving outcomes in patients with CAD. To enhance the results of PCI, various diagnostic and adjunctive techniques have been developed-most notably, … |
BON-KWON KOO; | 2026-01-07 |
| 76 | Clinical and Basic Research on The Treatment of Senile Atherosclerosis and Coronary Heart Disease With Yiyang Huoluo Decoction PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if Yiyang Huoluo Decoction (a custom Chinese herbal medicine) works safely and effectively to treat coronary heart disease with atherosclerosis in older adults. It also aims to find out how this herbal treatment may affect blood vessel health and repair at a cellular level. The main questions it aims to answer are: * Does adding Yiyang Huoluo Decoction to standard Western medical care improve symptoms and heart-related health in older adults with coronary heart disease and atherosclerosis? * Is Yiyang Huoluo Decoction safe for older adults to take alongside their regular heart medications? * How does this herbal treatment affect the damaged blood vessels in study participants? Researchers will compare two groups of participants to see if the combined treatment works better than standard care alone. Who can take part: Older adults diagnosed with coronary heart disease and atherosclerosis who meet the study’s health and eligibility rules. What participants will do: * Be split randomly into two groups of 15 people each: one group gets standard Western heart medicine only, and the other gets standard Western heart medicine plus Yiyang Huoluo Decoction (herbal granules) * Complete the 12-week decoction treatment plan as directed by the research team * Attend scheduled study visits for health checks, blood tests, heart and blood vessel scans (such as carotid ultrasound and coronary CTA), and symptom reviews * Provide two small blood samples for research testing (samples will be destroyed after study testing is finished) * Report any side effects, discomfort, or changes in health to the research team right away All personal health information collected for this study will be kept private and confidential. Participation is completely voluntary, and participants may quit the study at any time for any reason without losing access to regular medical care. |
XIA LIANG; | 2026-03-25 |
| 77 | Comparison of Initial Dual Oral COMbination Therapy to MOnotherapy in Pulmonary Arterial Hypertension With Cardiovascular ComorbiDITIES PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Pulmonary arterial hypertension (PAH) is a rare, progressive disease associated with poor prognosis, especially in patients with cardiovascular comorbidities. Current guidelines recommend initial combination therapy, but evidence is lacking for patients with significant comorbidities who are often excluded from clinical trials. The COMMODITIES trial is a multicenter, randomized, controlled study designed to compare the efficacy and safety of initial dual oral combination therapy (tadalafil and ambrisentan) versus oral monotherapy in newly diagnosed PAH patients with at least two cardiovascular comorbidities. The study aims to provide robust evidence to guide treatment strategies in this high-risk population. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-11-24 |
| 78 | A Prospective Study of Cardiovascular Risk of Patients Admitted for Acute Exacerbation of COPD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective study to assess the burden of existing or hidden cardiovascular (CV) and renal disease in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a Hong Kong public hospital setting. By implementing a chronic obstructive pulmonary disease (COPD) discharge care bundle with integrated CV/renal screening, the study aims to quantify undiscovered disease prevalence, evaluate risk factors for future exacerbations, and compare re-admission rates against historical controls, ultimately informing integrated cardiopulmonary management strategies. |
FANNY W.S. KO; | 2026-01-21 |
| 79 | International, Multicenter, Investigator-driven Randomized Clinical Trial to Assess The Single Vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With Drug-coated Balloons (PICCOLETO IV-EPIC 38) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients undergoing percutaneous coronary intervention (PCI) with the latest generation drug-coated balloon (DCB). The study includes patients with stable or unstable coronary syndromes and aims to assess rates of ischemic and bleeding adverse events. |
FONDAZIONE RICERCA E INNOVAZIONE CARDIOVASCOLARE ETS | 2026-01-22 |
| 80 | A Prospective Pilot Study to Evaluate The Safety, Tolerability and Efficacy of Utilizing Precise Computer Controlled Gas Challenge in Healthy Subjects for Identification of Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective pilot study to evaluate the safety, tolerability and efficacy of utilizing precise computer controlled gas challenge in healthy subjects for identification of coronary artery disease. |
ROHAN DHARMAKUMAR; | 2025-08-22 |
| 81 | Prognostic Impact of PHENOtyping De Novo Coronary Artery Disease Prior to Drug-Coated Balloon Angioplasty By Optical Coherence Tomography (PICCOLETO IX PHENO) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: To investigate whether pre-procedural OCT-derived de novo coronary lesion phenotype (lipid-rich, fibrotic, calcific; and ACS mechanisms such as plaque rupture/erosion/calcified nodule) is associated with clinical outcomes after DCB angioplasty. |
FILIPPO LUCA GURGOGLIONE; | 2026-02-05 |
| 82 | Incidental Noncardiac Findings on Coronary Computed Tomography Angiography PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Coronary CT angiography (CCTA) is increasingly used for ischemic heart disease diagnosis. The rising number of CCTA tests has led to a significant increase in the number of finding unexpected incidental extracardiac diseases. |
JORDAN COLLABORATING CARDIOLOGY GROUP | 2025-12-30 |
| 83 | Coronary Imaging and Metabolic Indicators-Based Risk Prediction Model for Coronary Artery Disease:A Retrospective and Prospective Cohort Study PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The primary design of this study is an ambispective cohort study. We plan to integrate coronary imaging features (including parameters derived from Coronary Computed Tomography Angiography(CCTA) and coronary angiography(CAG)), coronary functional indices (e.g., FFR, QFR), and metabolic biomarkers (e.g., LDL-C, Lp(a), hs-CRP). First, we will develop a multimodal risk prediction model for coronary artery disease using a retrospective cohort; subsequently, we will validate the model in a prospective cohort to assess its performance in discriminating high- versus low-risk individuals and to explore its potential clinical utility for risk stratification and decision-making. |
BEIJING ANZHEN HOSPITAL | 2026-01-20 |
| 84 | Cardiovascular Outcomes and Risk Evaluation Among Recipients of Hematopoietic Stem Cell Transplantation (CORE-HCT): A Prospective Multicenter Observational Study PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, multicenter observational study for recipients of hematopoietic stem cell transplantation. Patients who underwent hematopoietic stem cell transplantation at the participating centers will be entrolled in the study. The clinical characteristics, laboratory profiles, management measures, and clinical outcomes such as post-transplant cardiovascular events will be prospectively collected. |
XIAO HUI ZHANG; | 2026-01-16 |
| 85 | Exercise Echocardiography Registry for Ischemic and Non-Ischemic Heart Disease PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: Exercise echocardiography is a widely used non-invasive test that evaluates cardiac structure and function during physical stress. It provides important information on myocardial ischemia, cardiac performance, hemodynamic responses, and exercise capacity in patients with a broad range of heart diseases. However, real-world prospective data integrating exercise echocardiographic findings across both ischemic and non-ischemic heart disease remain limited. This prospective observational registry aims to systematically collect clinical, exercise, and echocardiographic data from patients undergoing clinically indicated exercise echocardiography. The registry includes patients with suspected or established ischemic heart disease as well as those with non-ischemic cardiac conditions, such as cardiomyopathies, … |
IN HYUN JUNG; | 2026-01-26 |
| 86 | External Validation of Ischemia and Hemorrhage Risk Models in Patients With Coronary Heart Disease PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Thrombosis formation is the core mechanism for the occurrence of major adverse cardiovascular and cerebrovascular events in patients with coronary heart disease. Antithrombotic therapy is one of the most important treatment methods for secondary prevention of coronary heart disease. Antithrombotic drugs, while reducing ischemic events, often significantly increase the risk of bleeding. How to balance the risk of recurrent ischemic events and bleeding events in patients with coronary heart disease is a major challenge in the treatment of coronary heart disease. This project establishes a high-quality multicenter, prospective coronary heart disease cohort, … |
XUE YU; | 2025-12-19 |
| 87 | Electronic Real-Time Heart Team Decision-making Vs. Usual Care in Patients With Triple-Vessel Coronary Artery Disease and Diabetes Mellitus PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multi-center randomized controlled trial involving patients with 3-vessel coronary artery disease and diabetes mellitus. Enrolled patients will be dividing into real-time heart team decision-making group (intervention group) and usual care group (control group). The intervention group will conduct a real-time online multidisciplinary heart team discussion and decision-making during coronary angiography. The control group will conduct an usual care decision-making. |
CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES | 2026-01-08 |
| 88 | Intravascular Imaging-Guided Versus Angiography- Guided Percutaneous Coronary Intervention for Drug-eluting In-stent Restenosis PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study aimed to compare the clinical and angiographic outcomes of patients with DES-ISR who underwent repeat PCI with intravascular imaging or angiographic guidance. |
FEI YE; | 2025-12-22 |
| 89 | Efficacy Evaluation of Glimepiride in Patients With Type 2 Diabetes Mellitus and Chronic Heart Failure With Reduced Ejection Fraction: A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Evaluating the safety and efficacy of glimepiride in patients with type 2 diabetes and chronic heart failure with reduced ejection fraction–a multicenter randomized controlled study. |
DAO WEN WANG; | 2025-12-17 |
| 90 | Digital Remote Management for Care and Continuous Optimization Versus Usual Care in Patients With Coronary Heart Disease (DigiCare-CHD) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The DigiCare-CHD study is an investigator-initiated, multicenter, open-label, parallel-group randomized controlled trial. It aims to evaluated the efficacy of a smartphone-based digital remote management platform compared to usual care in achieving dual goal attainment of blood pressure and LDL-cholesterol levels in patients with coronary heart disease following percutaneous coronary intervention. |
CHANG SHENG MA; | 2026-01-12 |
| 91 | Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective single-center cohort study conducted at The First Affiliated Hospital of Xinjiang Medical University, aiming to enroll 400 patients with chronic heart failure (including HFrEF, HFmrEF, HFpEF) and 200 healthy controls.We will collect clinical data (e.g., NYHA class, NT-proBNP), multi-omics samples (genome, proteome, metabolome, gut microbiome), and imaging indicators (e.g., EAT density, myocardial strain) from participants at baseline. For patients treated with SGLT2 inhibitors, … |
XIANG XIE; | 2026-01-21 |
| 92 | Etude De L’hyperlipoprotéinémie A Comme Marqueur De Risque Cardio-vasculaire Chez Les Patients Atteints De Maladie Rénale Chronique Au Stade 4 PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The blood level of lipoprotein A (Lp(a)) is linked to mutations in gene 6 and is associated with atherothrombotic risk and clinical manifestations such as myocardial infarction, ischemic stroke, and aortic valve calcification and stenosis. Several studies show an increased cardiovascular risk for a level \>125 nmol/L. Patients with severe chronic kidney disease (CKD) or on hemodialysis are at high cardiovascular risk, … |
OLIVIER MORANNE; | 2025-11-24 |
| 93 | Brain Ultrafast Ultrasound Imaging: Application in Pediatric Cardiology: Brain Ultrafast PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Congenital heart defects affect 1 in 100 births in France, with rising prevalence due to better care. Despite improved survival, 40% of children post-surgery face neurological impairments, and some of them show brain lesions. Causes include heart defects, genetic syndromes, and surgeries. Some heart defects and support systems increase cerebral risks. Monitoring cerebral perfusion is difficult to assess but emerging ultrafast ultrasound offers real-time, non-invasive blood flow insights. |
UNIVERSITY HOSPITAL BORDEAUX | 2025-12-23 |
| 94 | Inflammatory Profile in Patients Hospitalized for Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Its Correlation With Bioimpedance Parameters and Other Biomarkers With Prognostic Value PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to determine whether changes in the inflammatory profile of heart failure patients can help identify those who may have a worse prognosis or who might benefit more from specific treatments. In addition, we aim to explore whether certain genes or gene mutations are related to a higher risk of future cardiovascular problems. Heart failure continues to be a major cause of hospital admissions and death in our society. Because of this, it is very important for healthcare professionals to identify which patients are at higher risk of complications, … |
ANA MARÍA VENEGAS RODRIGUEZ; | 2026-01-06 |
| 95 | Assessment of Psychiatric Problems in Pre- and Post-Intervention in Patients With Congenital Heart Disease: A Prospective Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the relationship between cardiac intervention and subsequent psychiatric symptoms in patients with CHD. Due to the known high prevalence of mental health issues-with up to 50% of adults and 35% of pediatric patients with CHD experiencing mood or anxiety disorders-this research is crucial for improving long-term psychosocial care. The main questions it aims to answer are: * What is the prevalence of psychiatric problems in CHD patients? * Do psychiatric problems change or evolve after a cardiac intervention? * Who Can Take Part (Supporting Information) The study is actively recruiting patients who meet specific criteria: * Diagnosed with CHD and scheduled for a palliative or corrective cardiac intervention (surgical or catheter-based). * Patients of both genders can participate. Patients cannot take part if they have: * A current or pre-existing psychiatric or neurological disorder. – How the Research Will Happen This is a prospective, longitudinal cohort study that tracks the same participants over time. Participants will be asked to complete a series of validated psychological and cognitive assessments at three specific time points: * T0 (Baseline): Before the cardiac procedure. * T1 (Short-term): Approximately 1 month after the procedure. * T2 (Long-term): Approximately 3 months after the procedure. Participants will complete standardized measures covering a wide range of topics, including: * Psychological symptoms (e.g., depression, anxiety). * Cognitive function (e.g., memory and attention). * Sleep quality. * Eating attitudes. * Suicidal ideation. Potential Benefits: This research is critical for identifying dynamic changes in mental health related to cardiac procedures and will help the medical community understand the psychological impact of these interventions, leading to better screening and long-term quality of life. |
SHROUK ALAA-ELDEIN ABDALLAH; | 2026-01-08 |
| 96 | Impacts of Home-based Cardiovascular Rehabilitation on The Physical Fitness of Children, Adolescents and Young Adults With Congenital Heart Disease: The Muscle Your Heart Program PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Standard cardiovascular rehabilitation is performed in a medical care and rehabilitation centre. However, it may not be adapted to the patient’s profile and there are few medical care and rehabilitation centres specialized in pediatric cardiology. The objective of this study is to evaluate the impact of cardiovascular rehabilitation entirely at home on the physical fitness of young patients with congenital heart disease. |
PR PASCAL AMEDRO; | 2025-08-11 |
| 97 | Pregnancy Outcomes in Patients With Adult Congenital Heart Disease Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if a biomarker assay obtained peripartum (1st-3rd trimester and post-partum) in patients with adult congenital heart disease can predict future risk of cardiovascular adverse events and determine if temporal changes in biomarkers levels throughout the peripartum period can provide a better risk prediction compared to samples taken at a single time-point. |
ALEXANDER C. EGBE; | 2026-03-19 |
| 98 | Protective Effect of Enhanced External Counterpulsation Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Enhanced external counterpulsation (EECP) is a noninvasive, non-pharmacologic intervention proven to increase nitric oxide bioavailability in patients with coronary artery disease. Although EECP showed short-term effects in improving coronary flow in patients with coronary slow flow, whether such improvement is durable remains uncertain, and the relationships between such improvement and changes in multiple organ functions as well as inflammatory markers have not been elucidated. The purpose of this study will be to evaluate the potential clinical benefits of EECP on organ function and proinflammatory cytokine concentrations during post-acute sequela of cardiovascular surgery. |
HONG LIU; | 2025-12-31 |
| 99 | Optimization and Validation of Quality Control Indicators for Coronary Revascularization Based on Antiplatelet Therapy: Establishment of A Quality Control Standard System for Coronary Revascularization in Coronary Heart Disease Based on Dual Antiplatelet Therapy (DAPT) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Study Purpose Coronary heart disease (CAD) is a leading global cause of death, with Acute Coronary Syndrome (ACS) as its acute and life-threatening subtype. Percutaneous Coronary Intervention (PCI) plus stent implantation is the first-line treatment for ACS, and post-PCI Dual Antiplatelet Therapy (DAPT, aspirin + P2Y₁₂ inhibitor) is core for thrombosis prevention but increases bleeding risk. Approximately 40% of ACS patients are classified as High Bleeding Risk (HBR). China lacks a unified DAPT quality control system, … |
HAN YALING; | 2026-01-21 |
| 100 | The Correlation Between Obstructive Sleep Apnea-Related Nocturnal Hypoxemia Parameters and Coronary Microvascular Dysfunction: A Prospective Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In a cohort of patients with suspected myocardial ischemia undergoing sleep studies, the objectives of this study were: 1. To determine the association between various obstructive sleep apnea (OSA)-related nocturnal hypoxemia parameters and coronary microvascular dysfunction (CMD) in patients with suspected myocardial ischemia. 2. To compare the predictive value of nocturnal hypoxemia parameters versus the traditional Apnea-Hypopnea Index (AHI) for coronary microvascular dysfunction. 3. To evaluate the prognostic value of nocturnal hypoxemia parameters in predicting Major Adverse Cardiovascular Events (MACE) during the follow-up period. 4. To explore the potential mediating roles of inflammatory and oxidative stress biomarkers in the relationship between nocturnal hypoxemia parameters and coronary microvascular dysfunction. |
BEIJING ANZHEN HOSPITAL | 2026-01-02 |
| 101 | A Prospective, Multicenter, Randomized Controlled Trial to Investigate The Value of Coronary CT Angiography in The Understanding and Management of Coronary Calcium PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) will improve procedural efficiency and effectiveness compared with the current standard of care (IVUS-guided PCI) while achieving similar clinical outcomes in patients with hemodynamically significant calcified coronary artery disease. |
FUNDACIÓN EPIC | 2026-02-10 |
| 102 | A Multicenter Randomized Controlled Trial of Echocardiography-Guided Atrial Septal Defect Closure Performed in A Mobile Surgical Unit PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Cardiovascular disease remains a major threat to global health, and structural heart disease which encompassing congenital heart defects, valvular disease, and cardiomyopathies constitutes a substantial proportion of its burden. Atrial septal defect (ASD) is among the most common congenital heart conditions, occurring in approximately 1.6 per 1,000 live births. Percutaneous closure of ASD has become the standard treatment due to its minimally invasive nature and proven efficacy. However, conventional closure procedures rely heavily on fluoroscopic guidance and iodinated contrast, which carry risks of radiation exposure, contrast-related harm, and limit applicability in specific patient groups. Moreover, … |
CHENG WANG; | 2025-12-09 |
| 103 | Impact of Iron Deficiency With and Without Anemia on Arrhythmic Events and Resting ECG Abnormalities in Patients Hospitalized With Heart Failure PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The relationship between iron deficiency (with or without anemia) and arrhythmic risk or ECG abnormalities in hospitalized HF patients remains poorly characterized. This is particularly relevant in settings where advanced iron therapies (e.g., intravenous iron supplementation) may not be readily available, … |
SAMAR MOHAMED SADEK; | 2025-12-11 |
| 104 | Real-life Registry in Patients With Coronary Artery Disease Treated With The SELUTION Sirolimus-eluting Balloon. Selution Iberia Registry PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Selution Iberia registry is a post-market clinical follow-up, prospective, multicenter, international, longitudinal, observational study without a control group of consecutive unselected real-world patients with coronary artery disease in whom it was decided to use the SELUTION SLRTM device in the treatment of primary native lesions and ISR (in-stent restenosis) in all settings, … |
FUNDACIÓN EPIC | 2026-03-23 |
| 105 | Pattern of Congenital Heart Diseases and Developmental Evaluation in Children Below Two Years With Cholestasis at Assiut University Children’s Hospital PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Congenital heart diseases (CHDs) are common in infants with cholestasis due to shared prenatal and metabolic factors. This study aims to determine the frequency and types of CHDs and to assess physical and mental development in children below two years with cholestasis at Assiut University Children’s Hospital. |
SHIMAA AHMED MAHROS; | 2025-11-25 |
| 106 | Implementation of An Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease: OPTIMIZE ASCVD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, controlled, collaborative, multicenter, pilot implementation science study evaluating the hypothesis that algorithm- and multi-professional team-supported lipid management reduces low density lipoprotein-cholesterol (LDL-C) compared with usual care in patients with atherosclerotic cardiovascular disease (ASCVD). |
MARC BONACA; | 2026-01-23 |
| 107 | Stress As A Key Factor Influencing The Onset and Course of Cardiac Arrest PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to assess long-term stress in patients after an out-of-hospital cardiac arrest. To do this, we will measure levels of the stress hormone cortisol in hair samples. Cortisol is produced in larger amounts during periods of ongoing stress and builds up in the hair as it grows. Because hair grows about 1 cm per month, a 3 cm hair sample can show your average stress level over the past three months. The results will be compared with anonymized information from your medical records and the care you received before and during your hospital stay. |
JANA SMALCOVA; | 2025-12-16 |
| 108 | Current Status of Cardiovascular Diseases in Chinese Overweight/ Obesity Population: An Epidemiological Study (COPE） PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: This study is testing how overweight and obesity affect cardiovascular disease (CVD) prevalence, risk factors, and mortality among Chinese adults using nationally representative CCDRFS (China Chronic Disease and Risk Factor Surveillance) data. The purpose of the study is to characterize trends and determinants of CVD in adults with overweight or obesity and to quantify the excess mortality and population burden attributable to overweight/obesity. Participants will not receive any study medicine as this is an observational analysis of existing survey and mortality data. The study does not involve a new investigational drug; … |
NOVO NORDISK | 2026-01-22 |
| 109 | Influenza Vaccination After Acute Coronary Syndrome PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if influenza vaccination can prevent adverse cardiac events in Chinese acute coronary syndrome patients. The main questions it aims to answer are: * Whether influenza vaccination can decrease events of cardiovascular death, MI, or stroke? * Whether influenza vaccination can decrease events of all cause death, unplanned revascularization, unplanned hospitalization for heart failure or for arrhythmia, … |
DAO WEN WANG; | 2026-01-13 |
| 110 | CaRi-Heart® Assessment of Risk and Evaluation of Inflammation in Coronary CT Angiography (CARE-CCTA): A Prospective U.S. Community-Based Study on The Impact of CaRi-Heart® Analysis in Patients Undergoing CCTA for Coronary Artery Disease PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the use of CaRi-Heart® analysis, an artificial-intelligence (AI) software tool that measures inflammation in the coronary arteries using images already captured during a standard Coronary CT Angiography (CCTA) exam. The goal is to determine whether the additional information provided by CaRi-Heart® changes clinical decision-making and helps improve early identification and management of coronary artery disease in community imaging centers. Patients who undergo CCTA as part of their regular care will be invited to have their scans analyzed using CaRi-Heart® at no extra cost, time, or radiation. |
CORAZON MEDICAL PC | 2025-10-23 |
| 111 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate The Effect of Orforglipron on The Incidence of Major Adverse Cardiovascular Events in Participants With Established Atherosclerotic Cardiovascular Disease And/or Chronic Kidney Disease PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to measure cardiovascular outcomes with orforglipron compared with placebo in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD). Participation in the study will last about 5 years. |
DANIEL VOGEL; | 2026-03-20 |
| 112 | Short-Term Dual Antiplatelet Therapy With Early Transition to Low-dose Antiplatelet Monotherapy Using TicagRelor in Chronic Coronary Artery Disease PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, multicenter, randomized, open-label trial with blinded endpoint adjudication (PROBE design), comparing one-month dual antiplatelet therapy (DAPT) with low-dose ticagrelor (60 mg BID) followed by ticagrelor monotherapy to standard 6-month DAPT with aspirin and clopidogrel in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI). The primary endpoint is a composite of cardiovascular death, all-cause death, myocardial infarction, disabling stroke, target lesion revascularization (TLR), and major bleeding. The study aims to evaluate whether the short DAPT strategy reduces ischemic events while maintaining bleeding safety. |
RODOLFO CAMINITI; | 2025-07-23 |
| 113 | A Registry-Based Randomised Controlled Trial With Heart 4 Data – SELEnium and CoQ10 NuTrition for Heart Failure: H4D-SELEQT-HF PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether taking selenium and coenzyme Q10 (CoQ10) can reduce HF related events and deaths related to cardiovascular disease. Researchers will compare selenium-CoQ10 supplements with a placebo to see if the supplements improve heart health and patient outcomes. Participants will: Receive either selenium-CoQ10 or placebo in addition to their usual heart failure treatment Attend standard clinical visits according to routine clinical care. The study will include 1,100 adults with chronic heart failure. Selenium and CoQ10 are natural nutrients with no known health risks. If effective, … |
PETER VAN DER MEER; | 2025-11-21 |
| 114 | A Multi-Center, Prospective, Observational Registry for The Evaluation of Coronary Artery Calcified Nodules Using Intravascular Ultrasound (IVUS) And/or Optical Coherence Tomography (OCT) in China (CN-IVI Registry) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: What is this study about? This is a nationwide research study in China focused on understanding a specific type of challenging plaque in heart arteries called a Calcified Nodule (CN). The study will use advanced imaging technology inside the blood vessels to see these nodules in great detail, track how they are treated, and see how patients do in the long term. Why is this important? Calcified nodules are hard, … |
SHANGHAI ZHONGSHAN HOSPITAL | 2025-12-03 |
| 115 | Multicenter Randomized Controlled Trial (RCT) and Efficacy Evaluation System Study on Surgical Innovation Strategies for Neonatal Complex Congenital Heart Disease PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: There remains controversy regarding the optimal timing of surgical treatment for neonatal CCHD (Complex Congenital Heart Disease). Based on the established national multi-center database for surgical treatment of congenital heart disease and the prenatal-postnatal integrated diagnosis and treatment model, this study will conduct a multi-center RCT (Randomized Controlled Trial) to explore the optimal surgical timing for neonatal CCHD. It will also develop innovative comprehensive treatment strategies for critically ill neonatal CCHD patients, use RCT data to evaluate treatment efficacy and establish an evaluation system. This system will be gradually promoted nationwide, … |
QIHANG YANG; | 2026-01-23 |
| 116 | Sedation of Remazolam in Combination With Afentanil in Non-intubated Thoracoscopic Pulmonary Surgery: A Single-blind, Randomized, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Non-intubated Thoracoscopic surgery (NITS) is a newly emerging minimally invasive surgical technique in recent years . Compared with traditional intubation general anesthesia, it has the advantages of less trauma, faster recovery and fewer complications . This surgical method allows patients to perform under local anesthesia or regional block and moderate sedation, providing a physiologic ventilation method , reducing the intervention on the respiratory system and conducive to rapid postoperative recovery. The importance of sedative drugs in non-intubated thoracoscopic surgery Successful implementation of non-intubated thoracoscopic surgery requires sound regional block, airway management, … |
JIANBO WU; | 2025-07-24 |
| 117 | Relationship Between Red Cell Distribution Width (RDW) and HbA1C in Patients With Type 2 Diabetes Mellitus After Glycemic Control PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes mellitus (DM) is an epidemic disease, with approximately 463 million persons diagnosed with it. Of those, 90% are patients with type 2 DM (T2DM). Some estimates indicate that 700 million cases of DM will be reported in 2045. T2DM develops due to insulin resistance, leading to reduced insulin secretion. DM has a number of associated complications, such as nephropathy, neuropathy, and cardiovascular disease. |
ASMAA NADY HUSSEIN; | 2025-08-15 |
| 118 | A Comparison Between The Effect of Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia on Cerebral Perfusion Guided By Near Infra-red Spectroscopy in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Graft Surgery: (A Randomized Controlled Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better preserves cerebral oxygenation. |
AHMED HASANIN; | 2026-03-17 |
| 119 | The Role of Complement in Diabetic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes is a chronic condition marked by long-term elevated blood glucose levels. There are more types of diabetes; the majority of patients have type 1 or type 2 diabetes. Over long period of time, high blood sugar damages blood vessels and organs. One of the most common complications is diabetic kidney disease, which can slowly lead to kidney failure. People with this condition also have a much higher risk of heart and blood vessel diseases. Newer research shows that the immune system, especially the complement system (a group of proteins that help defend the body), … |
MIODRAG JANIĆ; | 2026-02-23 |
| 120 | A Phase I/IIa Study to Investigate The Safety, Tolerability, and Preliminary Effectiveness of HeXell-2020 in Patients With Stable Coronary Artery Disease (CAD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase I/IIa study to investigate the safety, tolerability, and preliminary effectiveness of HeXell-2020 in patients with stable coronary artery disease (CAD). HeXell-2020 is an investigational drug product consisting of allogenic umbilical cord mesenchymal stem cells (UCMSCs) as the drug substance. All enrolled and eligible subjects will receive HeXell-2020 treatment. |
HEXUN BIOSCIENCES | 2025-08-22 |
| 121 | Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced preeclampsia during pregnancy and subsequently developed chronic hypertension. The main Aims are: * To test the hypothesis that, in women with prior preeclampsia, current chronic hypertension, and concentric LV remodeling, eplerenone improves coronary microvascular function vs. chlorthalidone. * To test the hypothesis that, in women with prior preeclampsia, current chronic hypertension, and concentric LV remodeling, … |
MICHAEL C. HONIGBERG; | 2025-12-02 |
| 122 | Optical Coherence Tomography Angiography (OCTA) for The Assessment of Retinal Capillary Density in Patients With Cardiovascular Disease and A Healthy Control Group PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy individuals. The study will be conducted at the Clinical Research Centre (CRC), Department of Nephrology and Hypertension at the University of Erlangen-Nuremberg. |
AGNES BOSCH; | 2026-01-22 |
| 123 | Optical Coherence Tomography in Acute Vessel Evaluation (OCTAVE) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACS |
EVALD HOEJ CHRISTIANSEN; | 2026-02-20 |
| 124 | IMpact of PCSK9 InhibitoR InitiatiOn Before Percutaneous Coronary Intervention on Coronary MicroVascular Dysfunction and Events for Acute Myocardial Infarction: A Multi-center, Open-label, Randomized, Controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if drug tafolecimab works to treat participants with acute myocardial infarction (AMI) scheduled for primary percutaneous coronary intervention (PCI). It will also learn about the safety of drug tafolecimab. The main questions it aims to answer are: * Does drug tafolecimab lower the risk of 1-year major adverse cardiovascular events? * Does drug tafolecimab improve the coronary microvascular dysfunction? * What medical problems do participants have when administering drug tafolecimab by injection? Researchers will compare the results administering drug tafolecimab or not to see if drug tafolecimab works to treat AMI. Participants will: * Administer drug tafolecimab by injection or not every month for 12 months * Receive the standard of care of AMI * Complete the measurement of coronary angiography-derived microcirculation resistance index after PCI * Complete cardiac magnetic resonance after PCI if available * Visit the clinic at 1,6,12 months after the first administration for checkups and tests * Report any discomfort, event or queries at any time |
YUAN LU; | 2025-11-21 |
| 125 | Use of 3D-printed Models and Augmented Reality in Medical Student Education of Congenital Heart Disease: Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if 3D-printed heart models and augmented reality can be useful modalities to teach medical students about congenital heart disease. The main questions it aims to answer are: 1. Does using 3D-printed heart models improve learners’ understanding of congenital heart disease when compared to traditional slide-based teaching methods? 2. Does using augmented reality heart models improve learners’ understanding of congenital heart disease when compared to traditional slide-based teaching methods? 3. How can these modalities best be integrated into standard medical school curricula? Participants will: 1. Take a pre-test consisting of questions regarding anatomy and physiology of the normal heart as well as two congenital heart diseases. 2. Be randomized into 3 groups that receive a teaching session using either slide-based lecture, 3D-printed models, or augmented reality. 3. Take a post-test of the same questions from the pre-test. 4. Take a delayed post-test of the same questions with additional subjective questions about their experience with their assigned modality. |
ARPIT AGARWAL; | 2025-12-26 |
| 126 | Closed-Loop Neurofeedback Targeting The Right Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary Artery Disease With Anxiety – A Randomized, Sham-Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to test whether real-time fNIRS-BCI neurofeedback targeting the right dorsolateral prefrontal cortex (right DLPFC), using active volitional control during a slow-wave auditory acoustic paradigm, can suppress cardiac sympathetic activity and improve autonomic regulation in right-handed patients with stable coronary heart disease (CHD) and comorbid DSM-5 anxiety. The main questions it aims to answer are: Does real neurofeedback, compared with sham, reduce baseline-corrected heart rate during the auditory stimulation window? Does real neurofeedback, compared with sham, … |
LIN TAO; | 2025-11-20 |
| 127 | Inspire HER: Inspiring The Heart and Emotions for Radical Health PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group. We will refine and conduct a randomized, wait-list controlled trial of Inspire HER (a heart health lifestyle intervention for Black women that provides health education, physical activity, … |
TIMIYA NOLAN; | 2025-12-29 |
| 128 | Randomised Investigation of Physiological, Conventional and Optimised Resynchronisation Therapy in Heart Failure With Prolonged QRS Duration (RIPCORD-CRT) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to find out which type of specialist pacemaker-known as cardiac resynchronisation therapy (CRT)-works best for people with heart failure and a delay in how the lower chambers of the heart beat together (called electrical dyssynchrony). The main aims of the study are: To compare the effects of conventional biventricular pacing (BVP), conduction system pacing (CSP) and left-bundle optimised CRT (LOT-CRT) on heart failure symptoms and heart rhythm problems over six months. To explore how these pacing methods affect heart muscle strength, electrical activity, … |
ZACHARY I WHINNETT; | 2026-02-24 |
| 129 | A Prospective Cohort Study of Coronary Heart Disease Complicated With Ischemic Mitral Regurgitation in China PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This project will rely on the established multi-center cooperation platform for total valve disease and based on the Carpentier classification, which is newly proposed and widely recognized by the academic community, and will specifically target the population with coronary heart disease combined with Ischemic Mitral Regurgitation（IMR） to conduct a nationwide, multi-center, single valve disease, prospective cohort. Research. From November 2025 to December 2025, 6,000 patients with coronary heart disease combined with moderate or above IMR were consecutively selected from outpatients or inpatients in 21 regional medical centers across the country, and clinical characteristics, imaging data, and serology were collected. Information, … |
ERLI ZHANG; | 2025-11-17 |
| 130 | A Randomized Controlled Trial of The Efficacy and Safety of Yangxinshi Tablets in The Treatment of Patients With Coronary Heart Disease Complicated By Cardiac Dysfunction PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: A randomized controlled trial was conducted to evaluate the efficacy and safety of Yangxinshi tablets in improving the condition of patients with coronary heart disease complicated by cardiac dysfunction. |
SPH QINGDAO GROWFUL PHARMACETICAL | 2025-11-25 |
| 131 | Prospective Evaluation of Artificial Intelligence-enhanced Electrocardiography for Detection of Structural Heart Disease PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to improve the early detection of undiagnosed heart disease, which causes serious health issues, hospital admissions, and high healthcare costs. Researchers are exploring how artificial intelligence (AI) can analyse routine heart tests, called electrocardiograms (ECGs), to detect heart problems. These tests can be done using both traditional ECG machines and portable, wearable devices like smartwatches, making it easier for people to monitor their heart health at home. While AI has shown promise using past data, … |
IMPERIAL COLLEGE LONDON | 2026-03-09 |
| 132 | Randomized Controlled Study on The Effectiveness of Interventional Therapy for Non-Flow-Limiting Vulnerable Plaques PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this clinical trial is to explore the optimal preventative treatment strategy for non-flow-limiting vulnerable plaques. The main question it aims to answer is: Can interventional therapy further improve the outcome of non-flow-limiting vulnerable plaques on top of optimal pharmacologic therapy? Researchers will randomly assign patients who meet the inclusion criteria to preventative intervention plus optimal drug therapy (experimental group) or optimal drug therapy alone (control group). Participants will: Assigned to the control group: optimized drug therapy consisting of lifestyle improvement and intensive drug therapy including high-dose statin or other therapy to achieve target levels (low-density lipoprotein cholesterol \<1.4 mmol/L and decreased by 50% compared to the baseline). Lifestyle improvement and risk factor management included smoking cessation, nutritional optimization, physical activity, compliance with prescribed medications, and control of diabetes and hypertension. Assigned to the experimental group: all non-flow-limiting vulnerable plaques were treated with conventional second-generation drug-eluting stents. After the procedure, participants received dual antiplatelet therapy for about 12 months as well as other medications in the control group. |
XIAOFAN WU; | 2025-12-02 |
| 133 | Radiotherapy Vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized clinical trial is to test the efficacy of stereotactic body radiation therapy (SBRT) in treating ventricular tachycardia (VT) in patients with advanced structural heart disease. The main questions it aims to answer are: * What is the efficacy of SBRT compared to catheter ablation (CA) in achieving a ≥ 75% reduction in VT burden at 6 months * What is the comparable safety profile of SBRT vs CA Researchers will compare SBRT and CA (standard of care). |
SAURABH KUMAR; | 2026-02-18 |
| 134 | The Impact of Procedural Complications on Long-Term Mortality in Complex Coronary Interventions: The Multicenter COMPLEX-ANATOLIA Study PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The relative risks for different non-fatal intraprocedural complications during complex percutaneous coronary intervention (PCI) on subsequent mortality have not been described. This study aimed to assess the association between non-fatal intraprocedural complications and late mortality after complex coronary PCI. |
AHMET GUNER; | 2025-10-02 |
| 135 | The Effect of Erector Spinae Plane Block on Neurodevelopmental Outcomes of Neonatal Congenital Heart Disease Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Pediatric cardiac patients undergoing surgical anesthesia are at an increased risk of poor neurologic outcome (20-50%). Unattenuated anesthetic exposure and pain contributes to physiologic perturbations that may increase neurologic morbidity. Because of the often-large exposure to anesthetic agents in these cardiac children, at such a young age and the potential modifying anesthetic practice that could lead to improved neurodevelopmental outcomes and surgical recovery is paramount. Regional anesthesia such as thoracic epidurals provide effective analgesia and reduced intraoperative anesthetic needed but carry devastating sequelae neurological risks of epidural hematomas after anticoagulation during cardiopulmonary bypass (CPB). Recently, … |
CHI-HO BAN TSUI; | 2025-05-01 |
| 136 | A Pilot Study to Assess The Feasibility and Safety of Targeting Mean Arterial Pressure to Reduce Intra-operative Hypotension PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Randomized, multi-site, study assessing the feasibility of lower limit of autoregulation targeted mean arterial pressure (MAP) vs. standard MAP management in neonates undergoing cardiac surgery with cardiopulmonary bypass. After eligibility screening and consent, subjects will be randomized to either the intervention (study) or control group. |
BRADLEY MARINO; | 2025-10-30 |
| 137 | An Open-label, Blinded Phase II Study Investigating The Treatment of Acute Large Hemispheric Infarction By Transcranial Bone Marrow Injection of RK-4 Injection PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: An open-label, blinded phase II study investigating the treatment of acute large hemispheric infarction by transcranial bone marrow injection of RK-4 injection For subjects with acute large hemispheric infarction who are contraindicated to vascular recanalization or have poor response to vascular recanalization therapy, the safety, tolerability, and PK characteristics of RK-4 injection injected into the brain cell marrow through the cranial bone marrow will be preliminarily evaluated, … |
FUZHOU NEURODAWN RONGKANG PHARMACEUTICAL | 2025-10-02 |
| 138 | Dietary Fish Oil and Metformin Intervention for Heart Health in PCOS PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes. |
UNIVERSITY OF ALBERTA | 2025-12-12 |
| 139 | Finding Heart Failure in Those Prescribed Loop Diuretics in Primary Care in Jersey (FIND-HF LOOP) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether a simple blood test screening pathway can help diagnose heart failure earlier in adults in primary care who take loop diuretic medicines (such as furosemide or bumetanide) but do not have a recorded diagnosis of heart failure. The main questions it aims to answer are: 1. Does offering a NT-proBNP blood test to eligible patients increase the number of new heart failure diagnoses within 12 months compared with usual care? 2. Does this screening pathway also uncover other important heart problems, … |
AARON HENRY; | 2026-01-06 |
| 140 | THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE : A RANDOMIZED CONTROLLED TRIAL PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Study subjects were obtained from the pool of OPD patients in the Department of Conservative Dentistry and Endodontics, PGIDS, Rohtak, and the Department of Cardiology, PGIMS, Rohtak. Baseline clinical, radiographic, and laboratory parameters (hsCRP and IL-6) were recorded. Patients were then randomly allocated to one of the two groups. In the test group, single-sitting root canal treatment was performed immediately, while in the control group, … |
POSTGRADUATE INSTITUTE OF DENTAL SCIENCES ROHTAK | 2026-01-15 |
| 141 | Cohort Studies on Metabolic Syndrome and Prediabetes PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to establish a cohort of individuals with metabolic syndrome and prediabetes to enable long-term follow-up of risk factors, disease progression, and the development of obesity-related complications. The study will also monitor changes in nutritional status and physical function over time, in order to identify key prognostic determinants influencing clinical outcomes. Metabolic syndrome and prediabetes are chronic multisystem disorders, and poor long-term control is closely associated with the development of various complications. Moreover, malnutrition and functional decline are common comorbid conditions that further impair quality of life and impose a substantial burden on healthcare resources. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2025-11-24 |
| 142 | Screening Program for Structural Heart Disease Among Primary and Secondary School Students in Ruyang County PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational diagnostic study is to evaluate whether an artificial intelligence (AI)-enabled smart stethoscope can accurately detect structural heart disease in school-aged children and adolescents (10-18 years) in Ruyang County, China. The main questions it aims to answer are: Can the smart stethoscope reliably identify students with cardiac murmurs that indicate possible structural heart disease? How well do the sensitivity, specificity, … |
HEART HEALTH RESEARCH CENTER | 2026-03-03 |
| 143 | ClinicAL OutComes of IntraVascular Lithotripsy Combined With Conventional Lesion Preparation in Patients With Moderate to Severe Coronary Artery Calcification PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to investigate whether the clinical outcomes of combined application of intravascular lithotripsy (IVL) following routine preconditioning are superior to those of routine preconditioning alone in patients with moderate-to-severe coronary artery calcification (CAC). Its core research questions are as follows: A. To evaluate whether routine or combined application of shockwave intravascular lithotripsy can effectively reduce the target vessel failure rate in moderate-to-severe coronary artery calcification lesions. B. To evaluate the long-term prognosis of patients with coronary artery calcification. The researchers will compare the experimental group (routine preconditioning plus IVL) and the control group (routine preconditioning alone) to determine whether the combined use of intravascular lithotripsy following routine preconditioning can improve patient prognosis. |
BINGCHEN LIU; | 2026-01-14 |
| 144 | Cardiovascular Kidney and Metaboolic (CKM) Health Assessment and Patient Empowerment in ChROnic Disease Using A Health Coach INtervention ModEl: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of CHAPERONE solution is to evaluate the efficacy of engaging, assessing, and enabling long term treatment strategy with Health Artificial Intelligence (AI) Chatbot, Copilot, Large Language Model (LLM) and vital sign monitoring device in reducing CKM disease burden using an algorithm obtained from biomarkers and diagnostics utilizing remote sensor driven technology tools, care coordination and patient empowerment. |
ZAKI LABABIDI PI; | 2026-02-12 |
| 145 | PROACT 3: Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether disclosure of a polygenic risk score for coronary artery disease (CAD PRS) influences cardiovascular health and risk factor modification over one year among adults aged 30-75 years in the Mass General Brigham primary care network who are not currently taking LDL cholesterol-lowering medications. |
AKL C. FAHED; | 2026-03-23 |
| 146 | Persistent Atrial Fibrillation in Southwest China Cohort Study-Stepwise Strategy for Treatment of Atrial Fibrillation Substrate Extended Study PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This is an observational, bidirectional cohort study, aiming to establish a long-term registry of adult patients with Persistent atrial fibrillation (ps-AF) in Southwest China to characterize patient profiles and evaluate embolism risk, rate control, rhythm control and complication management and outcomes over 5 years’ follow-up. The objectives of the study are to: Describe the demographic, clinical, and treatment characteristics of ps-AF patients across Southwest China and assess the effectiveness and safety of various AF treatment strategies, including oral anticoagulation, electrical cardioversion, catheter ablation, and left atrial appendage closure, in routine clinical practice. Identify patient- … |
YUEHUI YIN; | 2026-02-02 |
| 147 | Coronary Computed Tomography Angiography Versus Standard Care in High-Risk Patients After Percutaneous Coronary Intervention PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the SMART-CARE trial is to compare clinical outcomes between coronary CT angiography (CCTA) versus standard care as follow-up strategies in high-risk patients after percutaneous coronary intervention (PCI). |
JOO MYUNG LEE; | 2025-12-19 |
| 148 | EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Inflammatory Cardiovascular Diseases and Autoimmune Rheumatic Diseases (ICARDs) encompass cardiovascular involvement in connective tissue diseases, vasculitis, and primary inflammatory cardiac processes affecting all layers of the heart. ICARDs are associated with increased cardiovascular morbidity and mortality, independently of traditional risk factors, via multiple pathophysiological mechanisms. Diagnosis and prognosis are challenged by the heterogeneity of clinical presentations. Multimodality cardiovascular imaging – including cardiovascular magnetic resonance (CMR), transthoracic echocardiography, and positron emission tomography (PET) – plays a central role in detecting and characterizing inflammatory involvement, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-07-22 |
| 149 | MULTIVALVE : A Prospective Multicentre Study of Multiple and Mixed Valvular Heart Disease PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Multiple and mixed valvular heart disease (MMVD) is a common condition in clinical practice. It corresponds to a combination of stenotic or leaky lesions on two or more heart valves (multiple valve disease), or a combination of stenotic and leaky lesions on the same valve (mixed valve disease). However, the management of their clinical, biological and cardiovascular imaging is not well established. Current European Society of Cardiology (ESC) recommendations primarily address the various valve diseases in isolation. This results in an absence of reliable recommendations for managing MMVD, … |
FRENCH CARDIOLOGY SOCIETY | 2025-09-16 |
| 150 | Effects of Surgical, Percutaneous or Medical Treatments for Coronary Artery Disease on Renal Function: Long-Term Outcome. Cardiorenal-trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Coronary artery disease (CAD) is treated with coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or optimized medical therapy (OMT). Their cardiovascular outcomes are well studied, but renal effects remain unclear. Objective: To evaluate long-term renal outcomes of different CAD treatment strategies. Methods: In this retrospective cohort from the MASS registry, patients with stable multivessel CAD and preserved ventricular function underwent OMT, CABG, or PCI. Annual creatinine was measured for ≥5 years, and eGFR calculated using CKD-EPI. The primary endpoint was change in renal function over time. Secondary endpoints included new-onset CKD, progression to advanced CKD, dialysis, … |
EZIO DE MARTINO NETO; | 2025-09-29 |
| 151 | Relationship Between Inflammatory and Hematological Indices and Coronary Artery Disease Severity and Outcome Among Diabetic Patients Undergoing Primary Percutaneous Coronary Intervention PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: ST-segment Elevation Myocardial Infarction (STEMI) remains a major cause of mortality despite the adoption of Primary Percutaneous Coronary Intervention (PPCI) as the standard treatment. However, outcomes still vary significantly among patients, especially between diabetic and non-diabetic cohorts. The research question driving this study is: Can hematologic, inflammatory, and thrombotic indices serve as reliable prognostic tools in predicting the no-reflow phenomenon and coronary artery disease (CAD) severity in STEMI patients, particularly among those with diabetes mellitus? Recent literature identifies inflammation as a key contributor to the pathogenesis and outcomes of Acute Coronary Syndrome (ACS), … |
DAVID EMIL EFRAIM DANIAL; | 2025-09-04 |
| 152 | Comparison of Clinical Outcomes Between Preoperative and Postoperative Revascularization in Coronary Heart Disease Patients With Time-Sensitive NOn-Cardiac Surgery: A Multicenter Pragmatic Randomized Controlled Trial (CHRONOS-PCI) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To compare the safety and efficacy of preoperative versus postoperative revascularization strategies in patients with coronary heart disease undergoing time-sensitive non-cardiac surgery. |
FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY | 2025-09-16 |
| 153 | Value of Speckle Tracking Echocardiography in Early Assessment of Cardiac Function in Inflammatory Bowel Disease Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Value of speckle tracking echocardiography in early assessment of cardiac function in inflammatory bowel disease . |
ASMAA ABDELSHAFY MOHAMED; | 2025-10-02 |
| 154 | Effect of Sodium Glucose Co-transporter 2 Inhibitors on Left Atrial Remodeling in Diabetic Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate and follow-up left atrial volume, diastolic function by 2D echocardiography and left atrial strain parameters using speckle-tracking echocardiography in patients with type 2 diabetes mellitus (T2DM) before and after treatment with SGLT2 inhibitors |
ABANOUB FAYOUMY SHAWKY; | 2025-09-22 |
| 155 | Incidence of Chromosomal Abnormalities in Patients With Congenital Heart Diseases Attending Assiut University Children’s Hospital PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Congenital heart disease (CHD) is one of the most common birth defects and an important cause of infant morbidity and mortality. Many children with CHD also have underlying genetic abnormalities, particularly chromosomal abnormalities, which may affect their prognosis, management, and counseling. This study aims to determine the incidence and pattern of chromosomal abnormalities among children with CHD attending Assiut University Children’s Hospital and Elmabara Insurance Hospital. Children with a confirmed diagnosis of CHD will undergo a detailed clinical assessment, including dysmorphic evaluation, … |
ALYAA RAMADAN IBRAHIM; | 2025-10-02 |
| 156 | Impact of Nocturnal Blood Pressure Dipping on Ventricular Repolarization in Hypertensive Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim is to determine whether non-dipping status is associated with adverse repolarization markers and impaired myocardial mechanics compared to dipper hypertensive patients. Secondary analyses will compare these findings among resistant vs. non-resistant and controlled vs. uncontrolled hypertensive groups. This study may provide new insights into the prognostic significance of blood pressure dipping patterns in hypertensive patients. |
AMR ABDELWAHAB HUSSEIN AHMED; | 2025-10-01 |
| 157 | The Role of Glucagon-Like Peptide-1 Receptor Agonists in Coronary Artery Diseases and Their Potential Mechanisms PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators plan to enroll 60 patients from the outpatient clinics or inpatient wards of the Metabolism and Cardiology departments who, within the past three months, have undergone coronary angiography for the treatment of coronary artery disease, are currently using sodium-glucose cotransporter-2 (SGLT-2) inhibitors for glycemic control, and have not received glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy for more than three months. A randomized controlled clinical trial will be conducted, with 20 participants randomly assigned to receive semaglutide (a GLP-1 RA) at 1 mg once weekly for 6 months, … |
TAIPEI VETERANS GENERAL HOSPITAL TAIWAN | 2025-07-18 |
| 158 | The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 2) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CVD, … |
INES DRENJANCEVIC; | 2026-03-09 |
| 159 | Effect of Hybrid Endurance and Strength Training (HyBEST) on Health-Related Outcomes and Quality of Life in Patients With Coronary Artery Disease During Phase II Cardiac Rehabilitation Program PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cardiac rehabilitation (CR) participation remains suboptimal, partly due to logistical challenges and limited access to center-based programs. Hybrid Endurance-Strength Training (HybEST) offers an alternative model by combining supervised endurance and strength exercises with home-based components. The main questions it aims to answer are: * Does a hybrid exercise program significantly improve a patient’s body function and structures \[exercise capacity, body composition, and muscle strength\] compared to usual care? * Does a hybrid exercise program significantly improve a patient’s activity \[functional capacity, physical activity, … |
ANWAR SUHAIMI; | 2025-08-19 |
| 160 | Echocardiographic and Electrocardiographic Findings in Pediatric Patients With Neurological Findings PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Evaluate the echo-electrocardiographic findings in patients with neurological affection to identify potential cardiac involvement, and explore correlation between cardiac and neurological abnormalities.Objectives are To assess echocardiographic findings in patients with neurological affection , to analyze ECG patterns in the same patient group and to explore clinical significance of detected cardiac findings in the management of neurological patients. |
ANDREW YOUSSEF QESTANDY YOUSSEF; | 2025-09-19 |
| 161 | Hemodynamic Evaluation and Assessment of DIRECT MyocaRdial and Sublingual Capillary Perfusion in Thoracic Surgery Patients on Cardiopulmonary Bypass PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: After cardiac surgery, some people may experience problems with their circulation or how well the heart pumps. This can occur because the smallest blood vessels in the heart do not function properly. When these vessels don’t work correctly, organs and tissues don’t receive enough oxygen and nutrients, which can lead to circulatory problems and organ damage. Typically, treatments focus on improving the larger blood vessels, such as blood pressure and heart function, but the investigators don’t yet know enough about the smallest blood vessels. In this study, … |
UFUK BALDAN; | 2025-08-22 |
| 162 | Impact of A Program Aimed at Improving Frailty in Patients With Stable Ischemic Heart Disease in Primary Care: Fragicor Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to improve the frailty in old patients who have a cardiac disease . Researchers will determine the improvement in the instability and the strength along twelve sessions based on guided exercises and mobility techniques made by physiotherapists. Research team will also evaluate the medications and diet, as well as laboratory and clinical tests. |
FUNDACIO D’INVESTIGACIO EN ATENCIO PRIMARIA JORDI GOL I GURINA | 2026-01-28 |
| 163 | Optical Coherence Tomography for Stent Optimization and Its Impact on Short-Duration Dual Antiplatelet Therapy: A Single-Center, Prospective, Exploratory Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate whether the use of optical coherence tomography (OCT), an advanced intravascular imaging tool, can improve stent implantation results and make it possible to shorten the duration of dual antiplatelet therapy (DAPT) in patients with stable angina who undergo percutaneous coronary intervention (PCI). PCI with drug-eluting stents is a standard treatment for patients with stable angina, and these patients are usually prescribed DAPT for 6 to 12 months to prevent stent thrombosis and other complications. However, extended use of DAPT increases the risk of bleeding, which can lead to significant medical problems, … |
KOREA UNIVERSITY GURO HOSPITAL | 2025-12-17 |
| 164 | Characteristics And Clinical Course Of Disease In Participants With Cardiomyopathy Associated With Friedreich Ataxia (CLARITY-FA) PF:2 Related Papers Related Patents Related Grants Related Experts Abstract: Study LX2006-02 is a prospective, longitudinal, low-intervention, multicenter, global study aimed at characterizing the nature and rate of cardiac disease progression in … |
LEXEO THERAPEUTICS | 2026-02-06 |
| 165 | Effect of Sacubitril/Valsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection Fraction PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effect of sacubitril/valsartan in patients with prosthetic heart valves with heart failure with reduced ejection fraction (HFrEF). |
MOHAMMED ALI MOHAMMED HAMMAD; | 2025-09-30 |
| 166 | Resistance Training Among Women With Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to find out whether partly replacing aerobic interval training (AIT) with resistance training (RT) leads to greater improvements in physical fitness and muscle mass in women with coronary artery disease (CAD) during cardiac rehabilitation. The main questions this study aims to answer are: * Does combining RT (squats and pulling exercises with weights) with a reduced amount of AIT (cycling) improve aerobic fitness in the same way as AIT alone? * Does the combined training lead to greater improvements in muscle mass compared with AIT alone? * Does slow-speed RT (slower lowering phase) result in lower heart rate and blood pressure during exercise compared with normal-speed RT? Researchers will compare three exercise programs: * AIT only (control group), * AIT combined with normal-speed RT (1-second lifting, 2-second lowering), * AIT combined with slow-speed RT (1-second lifting, 5-second lowering). Participants will take part in a 12-week cardiac rehabilitation program and will train three times per week. At the start and end of the program, participants will complete a cycling fitness test, body composition assessment, blood sampling, two strength tests, and quality-of-life questionnaire. |
BORUT JUG; | 2026-01-21 |
| 167 | Redefining BMI: The Body, Mind, and Inflammation Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Emerging adulthood (18-25 years of age) is a critical developmental window to promote weight management and cardiometabolic health, particularly for emerging adult women. The primary purpose of this study is to test the preliminary efficacy of the intensive lifestyle intervention for EA women in reducing adiposity, as well as improving biomarkers of inflammation and metabolic risk over 12 months compared with a traditional behavioral weight loss intervention. This treatment program will be tested in emerging adult (EA) women ages 18-25 years old with a BMI of 25-50 kg/m\^2. |
JESSICA LAROSE; | 2025-12-17 |
| 168 | Prognostic Value of The C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index on Patients Undergoing Primary Percutaneous Coronary Intervention PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the relationship between the admission CALLY index and short-term adverse outcomes in STEMI patients undergoing PPCI. Specifically, it seeks to determine whether the CALLY index is associated with in-hospital and 30-day complications, including heart failure, arrhythmias, reinfarction, or death. Additionally, the study will assess the association between the CALLY index and procedural success, defined by post-intervention TIMI flow, as well as the complexity of coronary artery disease using the SYNTAX score. |
MADONA SAMY ANIS; | 2025-10-02 |
| 169 | ASSOCIATION BETWEEN SYNTAX SCORE AND LEUKOGLYCEMIC INDEX IN PATIENTS WIHT ACUTE CORONARY SYNDROME PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study looks at people who come to the hospital with acute coronary syndrome, a serious heart condition. When these patients first arrive, doctors take routine blood tests. We use these test results to calculate a value called the leukoglycemic index (LGI), which combines white blood cell count and blood sugar level. We also use a heart imaging score called the SYNTAX score to see how complex their coronary artery disease is. Patients are divided into two groups based on their SYNTAX scores: one group with lower scores (22 or less), … |
RUKIYE GONEN OZDEMIR; | 2025-12-11 |
| 170 | Efficacy Comparison Between Independent Auscultation By Primary Care Physicians and AI-Assisted Auscultation in Large-scale Screening for Congenital Heart Disease: A Cluster Randomized Controlled Trial in China PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: This study plans to conduct clinical validation of the model in real clinical settings, comparing it with primary care physicians and specialist physicians to ensure the model’s practicality. Through continuous optimization and practice, the study aims to use AI-assisted heart sound auscultation to empower the auscultation capabilities of primary care obstetricians, pediatricians, and non-cardiovascular specialists nationwide. This will not only reduce the missed diagnosis rate and improve the detection rate of existing CHD screenings, but also expand the coverage of current CHD screening networks, incorporating newborns, infants, preschool children, children, … |
KUN SUN; | 2025-09-26 |
| 171 | Focus on Levels of Awareness and Perceptions Regarding HsCRP in Identifying Systemic Inflammation in ASCVD, CKD and Heart Failure Management PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a survey-based study conducted among cardiologists and nephrologists treating people with Atherosclerotic Cardiovascular Disease (ASCVD), Heart Failure (HF) and Chronic Kidney Disease (CKD). Study participants will be recruited to complete self-administered online survey. The purpose of this research is to gather real-world evidence related to attitudes around systemic inflammation and specifically the awareness, perception, drivers and barriers, and use of hsCRP in clinical practice to identify systemic inflammation in people with ASCVD+CKD and HF. |
NOVO NORDISK | 2026-02-11 |
| 172 | Hamburg Acute Renal Injury Study PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The Hamburg Acute Renal Injury Study (HARIS) is a prospective observational cohort study aimed at investigating the mechanisms, risk factors, and clinical determinants of acute kidney injury (AKI) trajectories and consequences. |
TOBIAS B HUBER; | 2026-01-14 |
| 173 | Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH) PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: Complex pathophysiological interactions among obesity, metabolic risk factors, chronic kidney disease (CKD), and the cardiovascular system lead to poor cardiovascular-kidney-metabolic health (CKMH), which is a major determinant of premature morbidity and mortality. Poor CKMH may lead to cardiovascular-kidney-metabolic syndrome (CKMS) – the five-stage framework introduced by The American Heart Association (AHA) which accounts for the critical overlap between cardiorenal syndrome and cardiometabolic disease. Evidence from randomized controlled trials shows glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose co-transporter-2 inhibitors (SGLT2is) may improve CKMH in individuals with Type 2 Diabetes (T2D) and/ or obesity. However, … |
DANIEL WALKER; | 2025-09-23 |
| 174 | An Observational Multi-Country Post-Authorisation Safety Study to Evaluate The Risk of Serious Adverse Cardiovascular Events in Adolescent and Adult Patients With Severe Asthma Taking Tezepelumab PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the risk of serious adverse cardiovascular events in adolescent and adult patients with severe asthma taking tezepelumab compared to a population receiving standard of care treatment for severe asthma. |
PETER EGGER; | 2026-03-04 |
| 175 | Effectiveness of High-Energy Density Enteral Nutrition for Enhancing Physical Growth and Cognitive Brain Development in Infants With Congenital Heart Disease: A Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to compare the effect of high and ordinary energy density enteral nutrition for improving physical growth and brain cognitive development in infants with congenital heart disease after operation, as well as evaluate the safety of interventions. |
CHILDREN’S HOSPITAL OF FUDAN UNIVERSITY | 2025-08-26 |
| 176 | Prevalence of Liver Dysfunction in Paediatric Patients With Congenital Heart Disease: A Cross-Sectional Study at Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Liver dysfunction is a well-documented complication in patients with congenital heart disease (CHD). The mechanisms leading to hepatic dysfunction may be multifactorial. Key risk factors for liver dysfunction in CHD include prolonged hypoxemia, high venous pressure, and prolonged duration of heart disease. While global studies have extensively explored this association, the prevalence of liver dysfunction in CHD varies, with studies reporting hepatic fibrosis in 30-40% of Fontan patients, while regional data, particularly from Egypt, remain limited. In this research we aim to determine the prevalence of biochemical and radiological hepatic abnormalities in pediatric CHD patients attending Assiut University Children’s Hospital. |
YASMIN NASSAR MOHAMED AHMED; | 2025-08-27 |
| 177 | Validity and Reliability of The 6-Minute Pegboard and Ring Test in Patients With Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Coronary artery disease, a cardiovascular disease, causes significant mortality and morbidity. Due to the impairment of arterial blood flow in coronary artery disease, the heart muscle cannot receive an adequate blood supply during exercise, resulting in symptoms such as chest pain, shortness of breath, and fatigue, which can lead to a decrease in exercise capacity. The 6-Minute Pegboard and Ring Test is a simple, rapid, … |
MERAL BOŞNAK GÜÇLÜ; | 2025-09-09 |
| 178 | Cardiopediatric Home Monitoring Tool PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: We hypothesize that a home monitoring program combined with routine postoperative care significantly reduces morbidity and mortality after neonatal and pediatric cardiac surgery. This project differs from the previously published experiences by (a) providing an innovative telemedicine solution via the use of validated measurement sensors, (b) an alert system based on individualized standards, established for each care pathway, and (c) a protocolized response from medical teams in the management of alerts generated by the home monitoring tool. |
NANTES UNIVERSITY HOSPITAL | 2025-09-09 |
| 179 | Biomarker in Congenital Cardiac Surgery – SST2 Marker in Heart Failure in Congenital Heart Disease After Surgery Research and Translational Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Patients younger than 18 scheduled for congenital heart surgery will be assessed during and post-operatively as well as at the first follow-up after 9-12 month for the novel biomarker sST2. We will assess the marker independently and in evaluation with other blood biomarkers to evaluate sings of heart failure. Compared to established biomarkers, sST2 promises thereby to be less variable to factors like age or acute kidney injury, rendering it potentially more reliable in the field of congenital cardiac surgery. |
MARTIN SCHWEIGER; | 2025-11-17 |
| 180 | Atrioventricular (AV) Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillation (AF), Heart Failure and Preserved Ejection Fraction: Heart Rate Regularization Vs. Medical Rate Control PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to assess the clinical efficacy of physiological pacing combined with atrioventricular node ablation, in patients with Heart Failure with preserved Ejection Fraction (HFpEF) and well controlled permanent atrial fibrillation.The main question it aims to answer is that heart rate regularization added to physiological pacing – preventing the deleterious effect of right ventricular apical pacing – … |
FRÉDÉRIC ANSELME; | 2025-09-22 |
| 181 | Coronary Artery Bypass Surgery Versus Percutaneous Coronary Intervention in Patients With Isolated Chronic Total Occlusion of The Left Anterior Descending Artery: The RITUAL Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to compare coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in the treatment of isolated chronic total occlusion (CTO) of the left anterior descending (LAD) artery in terms of short- and mid-term clinical outcomes, myocardial revascularization success, and complication rates. |
SEFA SURAL; | 2026-01-28 |
| 182 | Improving Cardiovascular Health in Veterans With PTSD By Treating Trauma-Related Nightmares With NightWare PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD). The investigators also want to learn whether it improves cardiovascular health among this population. |
KERRIE L MOREAU; | 2025-09-12 |
| 183 | Comparison of Transcatheter Aortic Valve Replacement With Surgical Aortic Valve Replacecment: A Prospective, Multicenter, International, Randomized Controlled, Non-inferiority Study for Bicuspid Aortic Valve Stenosis (PROMIS-BAV) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the safety and effectiveness of the Transcatheter aortic valve and retrievable delivery system (VitaFlow Liberty®) for the treatment of severe bicuspid aortic valve (BAV) stenosis. |
MAO CHEN; | 2025-09-16 |
| 184 | Impact of Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the impact of the triglyceride-glucose (TyG) index on the angiographic profiling of non-diabetic patients with premature coronary artery disease (CAD). |
REMON SALEH ADLY; | 2025-09-05 |
| 185 | Invasive Hemodynamic Study of Structural Heart Diseases: A Monocentric, Non-Randomized Approach PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The VHD PV loop study intends to assess invasive right ventricular to pulmonary artery (RV-PA) coupling in patients with valvular heart disease (VHD). Invasive RV-PA coupling is measured by using conductance catheters, the gold standard assessment for ventricular physiology. Several non-invasive parameters have been reported as surrogates for this complex physiological entity, but none of them has been tested against the gold-standard in this population. Based on this, our main objective is to assess the correlation of imaging derived RV-PA coupling in comparison to the invasive measurement. |
ROBIN LE RUZ; | 2025-09-16 |
| 186 | Development of An Active Surveillance System for Adverse Reactions to Molecular Targeted Drugs Based on Biomarkers and Personalized Medicine and Its Impact on Patient Quality of Life PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This study will prospectively monitor cancer patients receiving chemotherapy (including molecular targeted therapies) for cardiovascular adverse events using biomarkers and imaging. The goal is to develop a predictive model for major adverse cardiovascular events (MACE) in this population by integrating both local factors (e.g. central venous catheter-related thrombosis) and systemic factors (e.g. age, comorbidities, genetic predisposition). An active surveillance system employing periodic cardiac evaluations (ECG, echocardiography) and biomarker measurements (troponin T, NT-proBNP) will enable early detection of cardiotoxic effects. The impact of these adverse events and the monitoring strategy on patients’ quality of life will also be assessed. |
XIAOYAN LI; | 2025-12-29 |
| 187 | Definition of Intra-procedural Optical Coherence Tomography (OCT) Clinical Impact, Both in Terms of Revascularization Indication and Procedural Result PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The starring optical coherence tomography during percutaneous coronary intervention guidance (OCT-AGEM) registry aims to evaluate the clinical impact of intra-procedural optical coherence tomography (OCT) in coronary revascularization, both in guiding revascularization decisions and optimizing interventional procedural outcomes, as well as assessing mid- and long-term clinical results. |
ROMAGNOLI ENRICO; | 2025-09-19 |
| 188 | Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study, entitled Psychological trauma, post-traumatic stress disorder, and resilience in adults with congenital heart disease in a large population sample, is to evaluate for exposures during a lifetime with congenital heart disease that may be associated with higher likelihood of developing PTSD. Primary aim: \- Identify individual patient characteristics (medical, psychosocial, socioeconomic, etc.) that are associated with a diagnosis of PTSD. Secondary aims: * Calculate the prevalence of those meeting PTSD criteria in the ACHD population using the gold standard diagnostic clinician interview, … |
DAVID J. HARRISON; | 2026-03-25 |
| 189 | A High-Temporal Resolution CT Platform for Imaging and Functional Evaluation of Heart PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective observational study aims to evaluate a high-resolution coronary CT platform (uCT SiriuX Pro) for non-invasive assessment of coronary plaque biomechanics and functional physiology in high-risk patients. The system enables CT-derived radial wall strain (CT-RWS), a novel biomarker reflecting plaque vulnerability, with potential correlation to invasive OCT findings and clinical outcomes. The study will assess the diagnostic performance and prognostic value of CT-RWS, along with a new CT-based index of systolic flow perfusion (CT-SFPR) for evaluating the hemodynamic relevance of myocardial bridging, compared to nuclear perfusion imaging. Additionally, … |
SHANGHAI ZHONGSHAN HOSPITAL | 2026-03-17 |
| 190 | Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death. There are two main types of ACS: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation ACS (NSTE-ACS). While the occurrence of serious heart rhythm and conduction disturbances is well established in STEMI, these complications are believed to be much less frequent in NSTE-ACS. However, their actual frequency in this population remains unclear due to limited studies, … |
SABRINA GARNIER-KEPKA; | 2025-08-08 |
| 191 | Vitamin K Antagonist in Rheumatic Heart Disease Patients With Mechanical Heart Valves: Our Current Status PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: VKA in RHD patients with MHV: our current status |
AHMED HASSAN ROSTOM IBRAHIM; | 2025-08-28 |
| 192 | Improvement of An Algorithm to Detect Structural Heart Murmurs in Adult Patients Using Electronic Stethoscopes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this study is to evaluate a machine learning model’s ability to detect murmurs indicative of structural heart disease (structural murmur) by analyzing phonocardiogram waveforms-and simultaneous electrocardiogram waveforms when available-in multiple auscultatory positions per subject. Diagnosis of structural murmur will be confirmed by gold-standard echocardiography and reviewed by an expert panel of cardiologists. |
EKO DEVICES | 2025-10-01 |
| 193 | Prevalence of Gastrointestinal Bleeding in Ischemic Heart Disease Patients Undergoing Single Compared to Dual Antiplatelet Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Gastrointestinal bleeding is blood loss in the digestive tract, classified as upper or lower. Ischemic heart disease is due to blocked heart arteries. Antiplatelet drugs help prevent heart attacks but increase GI bleeding risk, especially when used together as dual therapy. This study aims to compare the prevalence and risk of gastrointestinal bleeding in ischemic heart disease patients on single versus dual antiplatelet therapy, and to explore strategies for reducing gastrointestinal bleeding in these patients, enhancing treatment safety without compromising cardiovascular protection. |
ABDULRAHMAN ANTAR MOHAMED; | 2025-08-15 |
| 194 | Assessment of The Correlation Between Lipoprotein (a) Levels and Coronary Artery Findings on Multislice Computed Tomography PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to evaluate whether serum Lipoprotein(a) \[Lp(a)\] levels are associated with coronary artery calcium (CAC) score measured by multi-slice computed tomography (MSCT) in adults undergoing cardiac risk assessment. The main questions it aims to answer are: * Is there a correlation between elevated Lp(a) levels and higher CAC scores? * Does Lp(a) provide additional predictive value for subclinical atherosclerosis beyond traditional cardiovascular risk factors? Participants will: * Undergo a non-contrast MSCT scan to measure CAC score. * Provide a blood sample for measurement of Lp(a) and routine lipid profile. * Have baseline clinical and demographic data collected, including cardiovascular risk factors. |
KEROLOS AYMAN SOBHY KAMEL; | 2025-09-19 |
| 195 | The Effect of Acapella and Incentive Spirometry on Blood Gases and Peak Expiratory Flow Rate After Coronary Artery Bypass Graft: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if whether the Acapella and Incentive Spirometry have effect on Blood Gas and Peak Expiratory Flow Rate among patients undergoing Coronary Artery Bypass Graft Surgery. the main question it aims to answer is: * What is the most effect of using a capella versus incentive spirometry on blood gas parameters (pao2 and paco2) and Peak Expiratory Flow Rate in patient undergoing coronary artery bypass grafting? * is the incentive spirometry have effect on blood gases parameters and Peak Expiratory Flow Rate? * is the Acapella have effect on blood gas parameters and Peak Expiratory Flow Rate? Researcher will Compare the Level of Blood gases and Peak Expiratory Flow Rate between Coronary Artery Bypass Graft patients who receive Acapella and Incentive Spirometry and those who do not receive it to see if the Acapella and the Incentive Spirometry work to enhance the level of blood gases parameters and Peak Expiratory Flow Rate. participant will take Acapella and incentive Spirometry on day before surgery and for three days after Surgery for 10-15 min for each session two times a day. |
BASSIMA AMIR NAJI OMAR HILMI; | 2026-01-13 |
| 196 | Exercise-induced Cardioversion in Persistent Atrial Fibrillation (ExPAF): A Feasibility Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to to evaluate the feasibility of conducting a larger randomized controlled trial (RCT) to assess whether an exercise stress test on an ergometer bicycle could induce sinus rhythm in patients with persistent AF scheduled for electrical cardioversion and if this intervention (regardless of rhythm conversion) could improve health-related quality of life in these patients. |
PÄR HEDBERG; | 2025-06-06 |
| 197 | Effects of Coffee Versus Hibiscus Tea Consumption During Prolonged Sitting on Blood Pressure and Heart Rate PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Modern lifestyles often involve long periods of sitting, which can increase the risk of heart problems, obesity, and other health issues. Diet also plays a key role in heart health. Coffee and hibiscus tea are two common beverages, but their effects during prolonged sitting are not well understood. This study will examine how drinking coffee versus hibiscus tea affects blood pressure, heart rate, and heart rate variability in men and women during extended periods of sitting. Participants (30 in total: 15 women and 15 men) will take part in a randomized crossover study, … |
ABDULLAH BANDAR ALANSARE; | 2025-09-08 |
| 198 | Comparison of Upper and Lower Limb Maximal Exercise Capacities, Arterial Stiffness, Muscle Oxygenation and Energy Consumption During Tests in Patients With Coronary Artery Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Coronary artery disease (CAD) significantly increases mortality rates in both developed and developing countries. In this condition, the impairment of arterial blood circulation leads to insufficient blood supply to the myocardium during both rest and exercise, resulting in symptoms such as angina pectoris, dyspnea, and fatigue. Patients, particularly due to their fear of experiencing angina pectoris, … |
MERAL BOŞNAK GÜÇLÜ; | 2026-02-03 |
| 199 | The Role of Phosphodiesterase 3B in The Regulation of Human Adipose Tissue Biology and Systemic Glucose and Lipid Homeostasis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Phosphodiesterase 3B (PDE3B), an enzyme responsible for the degradation of cyclic AMP and GMP (two important second messengers used for intracellular signal transduction), has been associated with cardiometabolic outcomes. Results from animal studies indicate that abolishing PDE3B function may be associated with unfavourable metabolic profile; however, preliminary human studies suggest that heterozygous loss of function (LoF) variants in the PDE3B gene have been associated with cardiometabolic improvements. Therefore, the effect of PDE3B on human adipose tissue metabolic pathways remains poorly understood. Accordingly, the investigators propose to conduct a recall-by-genotype, … |
MARIA CHONDRONIKOLA; | 2025-11-24 |
| 200 | Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In a significant portion of patients surviving a cardiac arrest, the event is caused by a myocardial infarction (a narrowing or blockage of one or more blood vessels that supply blood to the heart, the coronary arteries). In some people, this is immediately evident from basic tests; in others, … |
BERT POPELIER; | 2026-02-05 |