Clinical Digest: Recent Clinical Trials on Kidney Disease (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Kidney Disease. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Kidney Disease (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | The Effect of Different Fluid Therapy on Major Postoperative Morbidity in Patients Undergoing Non-donor Hepatectomy: A Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss. However, fluid restriction may lead to inadequate perfusion of vital organs and even contribute to postoperative organ dysfunction, such as acute kidney injury (AKI). Therefore, this study aims to compare the effects of restrictive versus liberal fluid therapy on major complications following hepatectomy. |
ZHIHONG LU; | 2026-02-27 |
| 2 | Research on The Prevention, Control, and Intelligent Management Decision-Making for Comorbidities of Chronic Kidney Disease and Metabolic Disorders in The Elderly PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to investigate the impact of metabolic comorbidities on outcomes in elderly Chinese adults, through two parallel sub-cohorts: one comprising elderly individuals without chronic kidney disease (CKD) at baseline, and one comprising elderly patients with established CKD. The main questions it aims to answer are: Do metabolic diseases (diabetes, hypertension, hyperlipidemia, hyperuricemia, calcium-phosphorus disorders) increase the risk of incident CKD, major adverse cardiovascular events (MACE), … |
YUANJUN YANG; | 2026-03-27 |
| 3 | CAPTURE-HFpEF (Cardiovascular Assessment and Phenotyping for Timely Understanding and Recognition of Evolving Heart Failure With Preserved Ejection Fraction) PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to improve early detection, characterization, and understanding of heart failure with preserved ejection fraction (HFpEF) in adults at risk of or diagnosed with HFpEF, including men and women across Danish regions. The main questions to answer are: Can systematic cardiovascular screening and deep phenotyping improve early identification and classification of HFpEF? Which clinical, imaging, biomarker, and metabolic characteristics define subtypes (phenotypes) of HFpEF and predict disease progression and outcomes? Researchers will compare participants with HFpEF, participants at risk of HFpEF, and relevant control groups to see if differences in biomarkers, imaging findings, … |
EMIL WOLSK; | 2026-03-25 |
| 4 | Cobas® Lumira Collection of Venous and Capillary Blood Samples for The Research, Optimization and Calibration of New Diagnostic Devices (EVOLVE) PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a blood sample collection study, collecting venous and capillary blood samples from adult patients in the UK, with a range of health conditions. The purpose of this study is to collect blood samples to help develop, improve, and fine-tune new and existing diagnostic tests for the cobas® lumira instrument. This instrument is a diagnostic medical device with single-use test strips, that allows diagnostic testing right at the patient’s side. The aim is to improve doctors’ ability to monitor health conditions more quickly and easily. Approximately 30,000 patients are expected to participate in this study, … |
LUMIRADX UK | 2026-01-30 |
| 5 | Moxie: A Self-management Education and Support Program Using Advertising Principles to Reduce Rehospitalization for Cardiovascular-related Illnesses PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Health education and self-management support are key facilitators of health behaviours. Moxie is a mixed media, self-management, education and support program for Albertans living with cardiovascular-related chronic conditions. Moxie is built upon our previous work within the ACCESS study (2015-21, n=4761), a RCT that previously tested the Moxie intervention in Alberta. Results demonstrated that MOXIE reduced the rate of hospitalizations (notably for hypertension, angina, hyper/hypoglycemia, heart failure decompensation, and acute kidney complications) by 34% in a population of low-income seniors living with cardiovascular-related chronic conditions. However, before Moxie can be effectively implemented province-wide, … |
UNIVERSITY OF CALGARY | 2026-01-21 |
| 6 | A Randomized, Controlled Trial Investigating The Effectiveness and Safety of Uptitration of Guideline Directed MEdical Therapy in Heart Failure With A Reduced Ejection Fraction With Limited Standardized Kidney Function Assessments (RESUME-HF-Kidney) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) constitutes of four medications that substantially reduce morbidity and mortality, and improve quality of life. In routine clinical practice, various physician- and patient-related factors lead to suboptimal initiation and uptitration of GDMT to optimal dosing, which is associated with worse patient outcomes. A perceived major barrier to the optimalization of GDMT are changes in kidney function and electrolytes, which prompts physicians to halt uptitration, reduce doses, or even discontinue GDMT. Changes in kidney function and electrolytes during optimalization of GDMT are common, … |
JOZINE TER MAATEN; | 2025-12-18 |
| 7 | Identification of A Pharmacogenomic Signature for Anti-B Cell Precision Therapy in Membranous Nephropathy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The CONFUCIUS project aims to establish a personalised medicine framework for MN patients by integrating pharmacogenomics with other -omics technologies in order to identify biomarkers that predict response to RTX, ultimately enabling optimized treatment selection. Using a multiomics approach, we will analyse genetic variants, serum and kidney proteomics, and serum metabolomics profiles from a well-characterised retrospective cohort of MN patients to uncover predictive biomarkers of RTX response. This is a non-pharmacological interventional study, conducted on biological samples from patients stored in the local biobank and on samples from healthy volunteers, which will be collected and subsequently stored in the biobank. |
MATIAS TRILLINI; | 2026-02-18 |
| 8 | Effect of Nurse-led Intervention on Self-care Adherence and Quality of Life Among Patients Undergoing Hemodialysis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Hemodialysis is the most common treatment modality in patients with chronic kidney disease. The majority of people with dialysis have a below-average quality of life. Adherence to diet and fluid intake, engagement in physical activity, and feeling blue and anxious will all affect quality of life. Nurses play a key role in patient education and behavioral support. Nurse-led interventions, especially educational programs (laptop-based), combined with reminders and educational materials, may improve patients’ knowledge, adherence to treatment, … |
ABJA SAPKOTA; | 2026-04-02 |
| 9 | Impact of Folate Administration on One-Year Mortality in Patients With Infection-Associated Acute Kidney Injury: An Open-Label Randomised Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate if taking folic acid (a form of vitamin B9) can help reduce the risk of death and improve kidney recovery in adults with acute kidney injury (AKI) caused by infections or sepsis. The main question it aims to answer is: Does taking folic acid lower the chance of dying within one year for these patients? This study will also look at other important questions, such as whether folic acid helps kidneys recover faster (within 7 days), prevents long-term kidney problems (progression to chronic kidney disease at 3 months), reduces heart-related events, … |
YAQING JIAO; | 2026-01-29 |
| 10 | Dapagliflozin for Long COVID Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, placebo-controlled study. Patients with long COVID will be randomized to receive dapagliflozin or placebo for 12 months. |
IAN PATERSON; | 2026-02-20 |
| 11 | Clinical Outcomes Study of Mexican Patients With Chronic Kidney Disease on Renal Replacement Therapy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A descriptive, observational, prospective, multicenter study aimed at describing the main clinical outcomes of patients with chronic kidney disease receiving any form of renal replacement therapy in Mexico. |
OLYNKA VEGA; | 2026-03-16 |
| 12 | Impact of SGLT2 Inhibitors on Chronic Peritoneal Dialysis Patients: A Six-month Prospective .Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project aims to examine the effects of six-month treatment with selective SGLT2 inhibitor dapagliflozin in patients with end-stage kidney disease on chronic peritoneal dialysis. Methods: A prospective, open label, single-arm interventional clinical trial, will conduct at Nizwa Hospital from March 1st, 2026, to August 31th , 2026, and includes thirty (30) end-stage kidney disease diabetic and non-diabetic patients on chronic peritoneal dialysis, will receive selective SGLT2i Dapagliflozin 10 mg once daily (OD). Clinical and laboratory parameters will be assessed at baseline, then three and six months after drug initiation. The primary outcomes are:1- change in ultrafiltration volume, 2- … |
JEHAD AL LAHAM; | 2026-03-24 |
| 13 | Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of the BRAVE-HEART study is to learn if an amino acid infusion can reduce the risk of developing acute kidney injury after cardiac surgery in children. The main questions it aims to answer are: 1. Does an amino acid infusion decrease the number of participants with acute kidney injury? 2. Does an amino acid infusion decrease the number of days that participants are on a ventilator after cardiac surgery? Researchers will compare amino acids to a placebo (a look-alike substance that contains no drug) to see if amino acids decrease the number of participants with acute kidney injury. Participants will receive an amino acid or placebo infusion for up to 72 hours starting during cardiac surgery and only while in the operating room or the intensive care unit. |
STUART GOLDSTEIN; | 2026-03-23 |
| 14 | Impact of Expanded Hemodialysis Prescription on Global Uremic Toxin Removal Compared With High-Volume Online Hemodiafiltration: A Randomized Open-Label Crossover Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: People with advanced kidney disease need dialysis to remove waste products from the blood. Some of these waste products, called uremic toxins, are small, while others are medium-sized and more difficult to remove. Poor removal of these toxins may contribute to symptoms and long-term complications in patients on dialysis. Two dialysis techniques are commonly used to improve toxin removal beyond standard hemodialysis: expanded hemodialysis (HDx) using medium cut-off membranes, and high-volume online hemodiafiltration (HV-OL-HDF). Although both techniques are effective, … |
OLYNKA VEGA; | 2026-03-24 |
| 15 | Investigation on The Impact of Finerenone on Myocardial Remodeling in Patients With Diabetic Kidney Disease and Heart Failure PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the impact of Finerenone on myocardial remodeling in patients with diabetic kidney disease (DKD) and heart failure with a left ventricular ejection fraction (LVEF) ≥ 40%. The main questions it aims to answer are: 1. Does 6-month treatment with Finerenone significantly reduce myocardial fat infiltration (measured by MR Spectroscopy) and myocardial fibrosis (measured by extracellular volume fraction on CMR)? 2. Does Finerenone improve global left ventricular longitudinal systolic strain (GLS) and other structural remodeling indices in this patient population? Researchers will compare cardiac imaging parameters after 6 months of treatment to baseline values to see if Finerenone effectively reverses or slows down pathological cardiac changes. Participants will: 1. Take Finerenone (Kerendia) 10 mg or 20 mg orally once daily for a total of 6 months. 2. Undergo advanced cardiac imaging, including Cardiac Magnetic Resonance (CMR) and MR Spectroscopy (MRS), at the beginning of the study and after 6 months of treatment. 3. Receive regular clinical follow-up and blood tests to monitor safety (such as potassium levels and kidney function) and treatment efficacy. |
CATHAY GENERAL HOSPITAL | 2026-03-02 |
| 16 | Randomized Clinical Trial of Β Nicotinamide Mononucleotide in Patients Undergoing CABG Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators will perform a phase 2a, randomized, double-blind, placebo-controlled clinical trial in adult patients undergoing elective coronary artery bypass grafting (CABG) surgery to investigate the effects of oral nicotinamide mononucleotide (NMN) administration on myocardial NAD+ concentrations and on postoperative markers of myocardial and kidney injury. |
SHALENDAR BHASIN; | 2026-02-18 |
| 17 | A MULTIMODAL APPROACH TO PREDICTING SEPSIS-RELATED ACUTE RENAL INJURY: A PROSPECTIVE COHORT STUDY PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \[TIMP-2\]\*\[IGFBP-7\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis. |
EDA MACIT AYDIN; | 2026-03-16 |
| 18 | MRI Technical Development and Applications in Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Magnetic resonance imaging (MRI), as a non-invasive and non-contrast enhanced technique, has the potential to improve patient health care and management. The overall objective of proposed project is to: 1. develop, customize, and optimize anatomic and functional MRI methods, 2. explore the use of MRI methods to study CKD and evaluate post-transplant kidneys, and 3. investigate the potential of MRI in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction. In addition to direct studies of the kidney, … |
XIUFENG LI; | 2025-03-21 |
| 19 | Prospective, Randomized, Multicenter, Controlled Trial Assessing The Personalization of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Cardiogenic shock is a life-threatening condition characterized by inadequate cardiac output, leading to organ hypoperfusion and high mortality. Maintaining mean arterial pressure (MAP) is crucial, but standard targets may be insufficient due to venous congestion. Central venous pressure (CVP) can help assess effective perfusion pressure. This study investigates whether a personalized MAP target adjusted by CVP improves organ function and survival compared to standard MAP management. |
CMC AMBROISE PARÉ | 2026-04-02 |
| 20 | An Open-label, Multicenter Study to Assess The Effect of Zigakibart Treatment on Histologic, Circulating, and Excreted Markers of Kidney Disease and Dysfunction in Adult Patients With IgA Nephropathy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to assess the effect of zigakibart on IgA nephropathy (IgAN) disease progression. |
LAURA KOOIENGA; | 2026-04-01 |
| 21 | Monitoring of The Sympathetic/Vagal Balance Through Multiparametric Analysis of Heart Rate Variability (HRV) in Patients With Type 2 Diabetes Mellitus (Type 2 DM), With or Without Heart Failure And/or Chronic Kidney Disease, or Cardiomyopathy, With Heart Failure And/or Cardio-renal Syndrome, All Receiving Optimized Pharmacological Treatment, Including A Sodium-Glucose Co-transporter 2 Inhibitor (SGLT2i) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The autonomic nervous system (ANS) plays a crucial role in cardiovascular regulation by modulating heart rate in response to endogenous and environmental stimuli. Heart rate variability (HRV) analysis has been widely used as a non-invasive tool to assess autonomic function and the balance between sympathetic and parasympathetic activity. Although the physiological interpretation of some HRV parameters remains debated-particularly the low-frequency (LF) spectral component as an index of sympathetic activation-HRV remains an important method for evaluating autonomic cardiovascular control. Reduced HRV has been associated with adverse outcomes in several pathological conditions and physiologically declines with aging, … |
DONATELLA BRISINDA; | 2026-03-24 |
| 22 | A Parallel-group, Randomized, Prospective, Interventional, Double-blind, Multicenter Global Phase 3 Study to Investigate The Efficacy and Safety of Finerenone Versus Placebo, in Participants With Chronic Kidney Disease Not Using Renin-angiotensin-system Inhibitors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Study to demonstrate efficacy of finerenone when compared to placebo in reducing albuminuria in participants with chronic kidney disease (CKD) not using renin-angiotensin-system (RAS) inhibitors. |
HIDDO J. LAMBERS HEERSPINK; | 2026-04-01 |
| 23 | EFFECT OF PLAZEPOD VERSUS ELECTRICAL STIMULATION ON RISK OF FALLING IN HEMODIALYSIS PATIENTS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Renal nutrition Fluid control Safe physical activity Sleep hygiene, energy and managing fatigue Adherence and awareness |
SAMIA WAGDY EL SAID DIAB; | 2026-02-02 |
| 24 | A Multicenter, Randomized, Double-blind, Placebo- Controlled Phase III Study Evaluating The Efficacy and Safety of HRS-1780 in Adult Participants With Chronic Kidney Disease PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a Phase III clinical trial to evaluate the superiority of HRS-1780 tablets compared with placebo in delaying renal function decline in participants with chronic kidney disease (CKD) on the basis of standard treatment. |
ZHIHONG LIU; | 2026-03-27 |
| 25 | Improving Access to Nephrology Treatment and Care Among Patients at Greatest Risk for Kidney Failure PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Through the use of community-engaged processes, this project seeks to develop and implement clinical decision support (CDS) and a kidney health coaching (KHC) intervention. The CDS seeks to streamline workflows to effectively screen, identify, and link to care for those patients with advanced chronic kidney disease (CKD). The overall project goals are to 1.) Design and conduct community-engaged clinical trials to test new interventions that dismantle the systemic factors that contribute to kidney health disparities. 2.) Foster research collaborations between investigators, people living with kidney disease, community-based organizations, … |
KIMBERLY R JACOB ARRIOLA; | 2026-03-16 |
| 26 | Serum Uromodulin Prognostic Value in Sepsis Induced AKI PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To determine whether baseline (day 0; day of diagnosis),day 7 and on discharge serum uromodulin levels help predict clinical outcomes in adult patients with sepsis induced AKI. |
SHAYMAA IBRAHIM MOHAMMED HASSAN; | 2025-12-31 |
| 27 | Sodium-Glucose Cotransporter-2 Inhibitor for Amelioration of Acute Cardiorenal Syndrome: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious. Investigators will assess if SGLT2 inhibition improves a composite cardio-renal outcome (mortality, dialysis, AKI progression, decongestion metrics, heart failure symptoms). Secondary objectives of this study are to compare individual components of the composite outcome as well as changes in biomarkers of kidney injury, inflammation, repair and oxidative stress between those exposed to the SGLT2 inhibitor vs placebo. |
ABINET AKLILU; | 2026-03-13 |
| 28 | CARAMEL: Retrospective Study for Personalized Risk Assessment of Cardiovascular Disease in Menopausal and Perimenopausal Women Using Real World Data PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: This retrospective observational study, part of the EU-funded CARAMEL project, aims to develop and validate personalized cardiovascular disease (CVD) risk assessment models specifically designed for menopausal and perimenopausal women (ages 40-60). The study leverages Real World Data (RWD) collected from multiple international clinical partners, including electronic health records (EHR), diagnostic imaging data, and signal data. The main objective is to improve the prediction of CVD precursors such as hypertension and dyslipidemia, as well as mid- and long-term risk of CVD events, through advanced artificial intelligence (AI) models. These models will be trained on multimodal data to capture complex, … |
LUIS GABRIEL LUQUE ROMERO; | 2026-01-15 |
| 29 | An International Multicentre Prospective Study of Postoperative Acute Kidney Injury in Hospitalized Paediatric Patients PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, … |
ROBERT FRITHIOF; | 2026-04-01 |
| 30 | Pragmatic Trial of Messaging to Providers About Treatment of Chronic Kidney Disease PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a cluster-randomized clinical trial to evaluate whether a tailored, user-centered, clinical decision support (CDS) tool can positively influence prescriber behavior and increase prescription of guideline-directed medical therapy (GDMT) among patients with Chronic Kidney Disease (CKD) across a single healthcare center. |
FRANCIS P WILSON; | 2026-02-24 |
| 31 | Development and Validation of A Machine Learning-Based Risk Prediction Model for Acute Kidney Disease After Cardiac Surgery PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Renal injury after cardiac surgery is one of the common complications with high incidence rate, high risk of death and progression to chronic kidney disease (CKD). Previous evaluations of perioperative renal function mainly focused on acute kidney injury (AKI) related to cardiac surgery within seven days after surgery. The newly proposed concept of acute kidney disease (AKD) in recent years refers to acute or subacute kidney injury lasting seven to ninety days. Research has found that AKD can occur after AKI or in patients without AKI, and the two are both related and independent of each other, … |
CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES | 2026-03-19 |
| 32 | Evaluating The Clinical Effectiveness of Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The study investigates whether sodium bicarbonate is able to reduce the occurrence of major adverse kidney events on day 90 (MAKE90) in critically ill patients with metabolic acidosis and acute kidney injury (AKI). While its efficacy in this context has been suggested in a subgroup analysis of the BICAR-ICU trial it has not been confirmed in a double-blinded randomized controlled trial to date. |
UNIVERSITÄT MÜNSTER | 2026-03-11 |
| 33 | Frailty, Geriatric Syndromes and Care Pathways of Older Adults Living With HIV in West Africa PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: With currently available antiretroviral therapy, people living with HIV (PLWHIV) are living longer. This exposure to HIV and combination antiretroviral therapy may accelerate the aging of this population, … |
CLOTILDE ALLAVENA; | 2026-01-21 |
| 34 | CommunityRx-Kidney Health PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In the United States, the burden of chronic kidney disease (CKD) rests disproportionately on rural communities. This study evaluates the implementation and effectiveness of CommunityRx-Kidney Health (CRx-K); this health information technology intervention integrates medical, social, and self-care resources to improve CKD management in rural eastern North Carolina. Through a partnership among local primary care centers, community organizations, and researchers, CRx-K will strengthen rural care networks, improve CKD management, and enhance the well-being of rural communities. |
GAURAV J DAVE; | 2026-03-11 |
| 35 | Renal and HEpatiC AbnoRmal DopplEr PAtterns IN Trauma: A Multicentre Prospective Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about renal and hepatic blood flow abnormalities detected by bedside ultrasound in adult patients admitted to the intensive care unit (ICU) following major trauma. The main questions it aims to answer are: * How reliably can trained operators measure renal Doppler and venous congestion scores (RDRI and VExUS) across different hospitals? * How common are abnormal kidney and liver blood flow patterns in major trauma patients during the first 72 hours of ICU admission? * Are these abnormal patterns associated with acute kidney injury or the need for mechanical ventilation? Participants admitted to ICUs or high-dependency units (HDUs) with major trauma (Injury Severity Score \>15) will undergo non-invasive bedside ultrasound assessments at admission and at 24, 48, and 72 hours. No additional treatments or interventions will be given as part of this study. Kidney function will also be checked at 6 months after hospital discharge. |
LORENZO GAMBERINI; | 2026-03-25 |
| 36 | Concentrations of Kynurenine During Pregnancy in Women With or Without Chronic Kidney Disease: A Prospective Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic kidney disease (CKD) affects more than 10% of the population worldwide and represents the second most important risk factor for preeclampsia, a life-threatening complication of pregnancy responsible for approximately 80,000 maternal and 500,000 perinatal deaths each year. Experimental studies have suggested a causal link between CKD, relative kynurenine deficiency during pregnancy, and preeclampsia development. Kynurenine, a tryptophan metabolite, plays a central role at the materno-fetal interface, supporting placental energy production, maternal-fetal immune tolerance, and placental perfusion. This study will prospectively assess and compare longitudinal kynurenine concentrations in pregnant women with and without CKD, … |
CHU DE REIMS | 2026-02-17 |
| 37 | Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Adolescents With Persistent Albuminuria: A Randomized Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic kidney disease (CKD) is highly prevalent in the state of Aguascalientes, Mexico, particularly among adolescents and young adults. Epidemiologic and histologic studies suggest that this burden is largely driven by reduced nephron endowment of prenatal origin, leading to compensatory glomerular hyperfiltration, adaptive podocytopathy, and persistent albuminuria at early stages of disease. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have demonstrated nephroprotective effects in adult populations with CKD, including reductions in albuminuria and slowing of disease progression, independent of diabetes status. However, … |
CENTENARIO HOSPITAL MIGUEL HIDALGO | 2026-02-20 |
| 38 | Safety of RotigotiNe in Patients With Autosomal Dominant Polycystic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is caused by mutations in the PKD1 or PKD2 genes, which encode polycystins 1 and 2. Patients develop renal cysts associated with a progressive decline in kidney function, ultimately leading to end-stage renal disease in approximately one third of cases. ADPKD is also characterized by early-onset hypertension and cardiovascular complications, notably intracranial aneurysms. This phenotype is related to abnormal polycystin function in the primary cilia of renal epithelial and vascular endothelial cells, … |
UNIVERSITY HOSPITAL ROUEN | 2026-02-17 |
| 39 | GOaL Directed-STrategic Approach With New Disease-modifying TheraApies to Reduce Kidney and Cardiovascular Risk in Patients With Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: GOLD-STANDARD is a pragmatic, open-label pilot randomized controlled trial evaluating the feasibility and safety of early goal-directed Cardio-Kidney-Metabolic (CKM) care compared with usual care in patients with diabetic kidney disease. Participants will be randomized 1:1 and managed by nephrologists. The intervention includes structured kidney and cardiovascular risk assessment, early shared decision-making regarding guideline-directed medical therapies, and close monitoring for adverse effects. The usual care group will receive standard clinical management at the discretion of the treating clinician. The study will be conducted in Ontario using existing health care infrastructure. |
SUNNYBROOK HEALTH SCIENCES CENTRE | 2026-02-27 |
| 40 | The Role of Sodium Bicarbonate Enema in Improving Constipation and Reducing Uremic Toxins in Chronic Kidney Disease Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic kidney disease (CKD) is a progressive condition characterized by a gradual loss of kidney function, often resulting in the accumulation of metabolic waste products. One of the emerging areas of interest in CKD management is the gut-kidney axis, which highlights the interplay between gut microbiota and renal health. CKD patients frequently exhibit gut dysbiosis and increased production of gut-derived uremic toxins such as indoxyl sulfate and p-cresyl sulfate, … |
MOHAMED ALI GOUBARA ABDULHAQ; | 2026-02-06 |
| 41 | Community Pharmacist Prescription for Diabetic Kidney Disease (Rx4DKD): A Randomized Controlled Trial and Implementation Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Type 2 diabetes is the leading cause of chronic kidney disease, which can result in serious complications such as kidney failure and heart disease. Although effective medications exist to slow the progression of kidney damage, they are often underused in primary care, particularly for individuals without a regular family doctor. In response to this gap, 46 community pharmacy-led primary care clinics were launched across Nova Scotia in 2023 to serve under-resourced areas. Pharmacists at these clinics can prescribe for many chronic conditions, but currently not for diabetic kidney disease. To address this, the research team collaborated with kidney, diabetes, … |
JO-ANNE WILSON; | 2026-03-18 |
| 42 | Effect of A Synbiotic Containing Lactobacillus Rhamnosus, Bifidobacterium Longum, and Agave Fructans on High-Sensitivity C-Reactive Protein Levels in Patients With Predialysis Chronic Kidney Disease: A Double-Blind, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic kidney disease (CKD) is a long-term condition in which the kidneys gradually lose their ability to function properly. People with chronic kidney disease (CKD) often experience chronic inflammation and digestive symptoms that may affect their quality of life. This study aims to evaluate whether daily supplementation with a synbiotic (a combination of probiotics and prebiotics) can reduce inflammation and improve gastrointestinal symptoms in adults with chronic kidney disease (CKD) stages 3 to 5 who are not receiving dialysis. Participants will be randomly assigned to receive either a synbiotic containing Lactobacillus rhamnosus, Bifidobacterium longum, and agave fructans, or a placebo, … |
CENTENARIO HOSPITAL MIGUEL HIDALGO | 2026-02-27 |
| 43 | Avacopan Added to Standard-of-care Therapy in ANCA-associated Vasculitis With Severe Kidney Involvement: A Randomized, Placebo-controlled, Double-blinded Multicenter Superiority Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: ANCA-associated vasculitis (AAV) is a rare auto-immune disease, with high mortality in the absence of treatment. There is still an unmet need to define new treatment strategies to reduce drug side effects, as well as to reverse rare cases of refractory AAV and improve the kidney response to improve the long-term outcomes. Severe forms of AAV-related necrotizing and crescentic rapidly progressive glomerulonephritis (RPGN) (i.e. estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m²) are associated with higher mortality, higher incidence of infections, and long-term consequences including chronic kidney disease (CKD) with subsequent complications (end-stage kidney disease (ESKD) requiring dialysis, ... |
UNIVERSITY HOSPITAL TOULOUSE | 2026-01-28 |
| 44 | Transthoracic Echocardiography in Assessing Patients With Suspected Endocarditis – Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This single-center, prospective observational study evaluates the accuracy of transthoracic echocardiography (TTE) to rule out infective endocarditis (IE) in patients with suspected IE, with the goal of reducing unnecessary transesophageal echocardiography (TOE), a more invasive diagnostic test. Eligible patients are those admitted to the Department of Cardiovascular Sciences at Fondazione Policlinico Universitario Agostino Gemelli IRCCS (Rome, Italy) who undergo TOE for suspected IE within 15 days of a TTE. Clinical, laboratory, and echocardiographic variables will be collected to characterize the study population and support analyses of diagnostic performance and in-hospital outcomes. |
FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS | 2026-02-17 |
| 45 | The Effect of Joint Range of Motion and Benson Relaxation Exercises on Dialysis Adequacy, Treatment Adherence, and Quality of Life in Hemodialysis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to determine the effects of range of motion and Benson relaxation exercises applied to patients undergoing hemodialysis treatment on dialysis adequacy, treatment adherence, and quality of life. |
VOLKAN KINA; | 2026-02-13 |
| 46 | Prospective Analysis of Arteriovenous Access Use in Continuous Renal Replacement Therapy, A Feasibility Project PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Arteriovenous fistula or graft are the ideal hemodialysis access. Nonetheless the most common access type used for Continuous Renal Replacement Therapy (CRRT) is either a temporary or permanent hemodialysis catheter. Recommendations for the use of catheters to deliver CRRT in end stage kidney disease (ESKD) patients are lacking on data and subjective to anecdotal experiences and expert consensus. The repetitive placement of catheters in ESKD patients have shown to increase the chances of central vascular stenosis which is one of the main risk factors that lead to access failure. Also, … |
ARMANDO RODRIGUEZ LOPEZ; | 2026-03-03 |
| 47 | Cost-effectiveness Analyses for The Prevention of Acute Kidney Injury in Patients Undergoing Cardiac Surgery in The UK Related Papers Related Patents Related Grants Related Experts Highlight: Multi-centre retrospective analysis of prospectively collected data with propensity matched scoring groups (AKI v/s non-AKI). Data collection from databases (or their equivalent): PATS Dendrite, Electronic Medical Records, TD-web (results Portal), MedTrack (ICU database), iSite (Radiology), SPY (Long-term status) |
THE ROYAL WOLVERHAMPTON HOSPITALS NHS TRUST | 2026-03-16 |
| 48 | Investigating The Impact of Serum Potassium Levels on Prevalence and Risk Factors Associated With Management Strategies for Patients With Hyperkalaemia in Brazilian Clinical Settings: An Observational Study PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This is a descriptive, retrospective study involving patients from private cardiology, nephrology, and dialysis clinics in Brazil who participated in the National Hyperkalaemia Diagnosis Campaign. The study used anonymised data from the Hi Technologies Ltda. database. The objective was to estimate and characterise the prevalence of hyperkalaemia (HK), as well as to analyse the demographic profile, clinical characteristics, risk factors and treatment patterns associated with total blood potassium levels. |
ASTRAZENECA | 2026-01-27 |
| 49 | A Phase 1, Multicenter, Parallel-Design, Single Dose, Open-Label Study to Evaluate The Pharmacokinetics and Safety of Eloralintide in Participants With Severe Renal Impairment and End Stage Renal Disease (ESRD) Compared With Participants With Normal Renal Function PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to assess the amount of Eloralintide (LY3841136) that reaches the bloodstream and the time it takes for the body to get rid of it when given to participants with renal (kidney) impairment and to healthy participants. The study drug will be administered subcutaneously (SC) (under the skin). For each participant, the study will last about 14 weeks, excluding screening. |
PEDRO HERNANDEZ; | 2026-03-13 |
| 50 | Prognostic Value of Novel Biomarker on Adverse Renal Outcomes in High-Risk Cardiac Surgery Patients PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This project aims to detect novel biomarkers from preoperative and early postoperative serum and urine samples of patients to screen and analyze the risk factors for predicting adverse postoperative renal outcomes in high-risk patients in cardiac surgery. |
GUOWEI TU; | 2026-02-24 |
| 51 | A Prospective, Open-label and Single-arm Study of Human Umbilical Cord Mesenchymal Stem Cells in Preventing Arteriovenous Fistula Stenosis in Patients With End-Stage Diabetic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A Study on the Safety and Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in Preventing Arteriovenous Fistula Stenosis |
JIANGSU TOPCEL KH PHARMACEUTICAL | 2026-03-05 |
| 52 | A Multinational, Observational, Retrospective, Secondary Data Study Analyzing Dapagliflozin Effectiveness in Routine Clinical Practice Among Patients With Chronic Kidney Disease. Local Adaptation for Spain. Part 2 PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: This is a retrospective, observational study, using secondary data captured in electronic health records (EHRs). The study is a part of the OPTIMISE-CKD program to assess the current CKD treatment landscape, Dapagliflozin utilisation and characterization of incident CKD patient and the burden of disease within an observation period of 39 months (August 2020-November 2024) in two cohorts (preand post-reimbursement of Dapagliflozin for CKD) |
ASTRAZENECA | 2026-03-27 |
| 53 | A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled Trial to Assess The Effects of Oral TRPC6 Inhibitor BI 764198 Taken Over A 104 Week Treatment Period in Adult and Adolescent Participants With Primary Focal Segmental Glomerulosclerosis (pFSGS) or Genetic FSGS Related to TRPC6 Gene Variants PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is open to adults and adolescents with a kidney condition called focal segmental glomerulosclerosis (FSGS). The purpose of this study is to find out whether a medicine called BI 764198 helps people with FSGS. Participants are put into 2 groups randomly, which means by chance. Every participant has an equal chance of being in each group. One group takes BI 764198 tablets, … |
BOEHRINGER INGELHEIM | 2026-04-01 |
| 54 | Region-specific Adipose Tissues and Liver Changes Associated With Semaglutide Treatment in Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity is considered a global pandemic and is associated with various diseases and metabolic complications, such as type 2 diabetes mellitus, high blood pressure, cholesterol disorders, cancer, cardiovascular disease, and kidney disease. Obesity can affect the kidneys in two main ways: indirectly, through mechanisms related to diabetes mellitus and/or high blood pressure, and directly, through complex proteins called adipokines, which are produced by adipocytes. Many of these adipokines are secreted by adipocytes under normal conditions, as they contribute to maintaining immune defenses and energy production. However, in obesity these adipokines acquire harmful properties and produce chronic inflammation in vital organs, … |
PAOLO RAGGI; | 2026-02-03 |
| 55 | Application Research of Hydromorphinone Sustained-release Tablets in The Treatment of Elderly Patients With Cancer Pain Accompanied By Renal Insufficiency PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical study aims to understand whether domestic hydromorphinone sustained-release tablets are effective and safe in treating moderate to severe cancer pain in elderly patients with renal insufficiency. It will also understand key safety concerns, especially regarding renal function and neurotoxicity. The main questions it aims to answer include:1. Can hydromorphinone sustained-release tablets effectively relieve the pain of such patients and improve their quality of life?2. During the treatment period, what effect does this drug have on renal function (measured by eGFR)? 3. In this specific population, … |
XIAN’GUO WANG; | 2026-02-19 |
| 56 | A Phase 1b/2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Investigate A) The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses of IM-101 in Adult Participants With Generalized Myasthenia Gravis, and B) The Efficacy and Safety of Treatment of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of IM-101 in adult participants with AChR antibody-positive gMG. Subsequently, the safety and efficacy of the selected IM-101 dose-regimen will be tested in participants with AChR antibody-negative gMG and participants with AChR antibody-positive or AChR antibody-negative oMG. |
IMMUNABS | 2026-02-11 |
| 57 | A Pilot Randomized Waitlist-controlled Trial of A Zheng-based Chinese Medicine Intervention for Patients With Dialytic Hypotension in Taiwan PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the epidemiological status of traditional Chinese Medicine (TCM) constitution in patients with dialysis hypotension, and design a clinical study based on a common syndrome-based herbal formulation to evaluate the clinical efficacy and safety of TCM |
MING-YEN TSAI; | 2026-02-20 |
| 58 | Optimising Access to and Outcomes From Transplantation in Older Potential Kidney Transplant Recipients: Pilot Feasibility Study on Kidney Transplant-specific Comprehensive Geriatric Assessment (KT-CGA) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve the way older adults are assessed for kidney transplantation. The main questions it aims to answer are: Is it feasible and acceptable to deliver a KT-CGA alongside routine transplant assessment in older adults with advanced kidney disease? What is the effect of KT-CGA on decision-making about transplant listing and on patient-reported outcomes such as quality of life and frailty? Researchers will compare participants who receive the KT-CGA plus usual care to those who receive usual care alone. Participants will: Continue with their usual transplant assessment process If randomised to the intervention group, also complete the KT-CGA (a structured set of questionnaires, short memory and function tests, and discussions about wellbeing and support needs, taking about 45-60 minutes) |
ANTONIA J CRONIN; | 2026-02-19 |
| 59 | A Multicenter, Open-label Phase Ⅱ Study to Evaluate The Efficacy and Safety of LP-005 Injection in Patients With Complement-Mediated Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, open-label, proof-of-concept, phase Ⅱ adaptive basket clinical trial designed to evaluate the efficacy, safety, and pharmacokinetic profile of LP-005 Injection as add-on therapy to standard treatment in patients with complement-mediated renal diseases. |
MINGHUI ZHAO; | 2026-01-23 |
| 60 | Clinical Outcomes of C3 Glomerulopathy and IC-MPGN in Russia: Hybrid Retrospective – Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study is planned to study specificity of the clinical course and treatment outcomes of C3 glomerulopathy (C3G) and Immune-complex membranoproliferative glomerulonephritis (IC-MPGN) in patients aged under 18 years and 18 years and older in the Russian population in 2025-2028. The primary objective of the study is to estimate the frequency of complete or partial remission 12 months after morphological verification of the diagnosis. Assessment of demographic, clinical and laboratory, morphological characteristics at diagnosis and their relationship with the disease outcomes, primarily the disease progression and development of chronic renal failure, … |
NOVARTIS PHARMACEUTICALS | 2025-02-28 |
| 61 | Prospective Cohort Study on The Impact of Gut Microbiota and Serum Metabolites on Glycemic Variability and Clinical Outcomes in Patients With Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetic kidney disease (DKD) is one of the main complications of diabetes and a leading cause of end-stage kidney disease. Blood glucose variability is closely associated with disease progression in individuals with DKD. Recent evidence suggests that gut bacteria and their circulating metabolites may play important roles in regulating blood glucose variability and clinical outcomes. However, it remains unclear whether gut bacteria and blood metabolites influence DKD progression through effects on blood glucose variability. This study aims to (1) characterize gut bacteria and blood metabolites in individuals with DKD at different stages and levels of disease severity, … |
EIGHTH AFFILIATED HOSPITAL SUN YAT SEN UNIVERSITY | 2026-01-20 |
| 62 | Longitudinal Multicentre Clinical Study to Explore The Mechanisms Underlying Kidney Effect of SGLT2i in Diabetic Kidney Disease Patients at Risk of Disease Progression By Multiparametric Renal MRI and Biochemical Markers PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicentre and multi-national non-pharmacological, uncontrolled interventional study conducted in a clinical practice setting in DKD patients with CKD stages 1 to 3 with moderate or severe risk of renal function decline in chronic treatment with SGLT2i. The main aim of the study is to assess the independent role of baseline individual mpMRI markers (hemodynamic, oxygenation, microstructure, perfusion, and fat fraction) and biochemical markers of MMP-related pathways (MMP-10 and TIMP-1) in the prediction of chronic eGFR decline in the above mentioned patients who are on chronic SGLT2i therapy. |
MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH | 2025-12-08 |
| 63 | Comparative Study on The Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects in Patients Chronic Kidney Disease With Cardiovascular Disease /Heart Failure PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, investigators will compare the effect of vicadrostat combined with empagliflozin with the effect of spironolactone combined with empagliflozin on renal function and changes in protein profiles in blood and urine. The hypothesis is that the renal and cardiac responses between vicadrostat and spironolactone differ due to mechanistic differences in their mode of action. Spironolactone is a mineralocorticoid receptor antagonist (MRA) and exerts its effect on a receptor, or a type of receiver, found on various cells. Vicadrostat is an aldosterone synthase inhibitor (ASI) and inhibits aldosterone production. Therefore, both drugs affect aldosterone. However, … |
DAVID SMEIJERS; | 2025-12-26 |
| 64 | Bempedoic Acid Therapy for Polycystic Kidney Disease (BEAT-PKD) Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Autosomal dominant polycystic kidney disease (ADPKD), the most commonly inherited kidney disease, is characterized by the development of cysts in the kidney that impair function. Of those affected, half will progress to end-stage kidney disease by age 60, requiring dialysis or kidney transplant. To date, no effective and safe therapies exist for this deadly disease. Tolvaptan (Tol), the only FDA-approved drug for treatment of ADPKD, has some benefit in slowing kidney disease progression, but Tol causes frequent urination and thirst and also injures the liver in a small number of patients. The investigators’ goal, therefore, … |
KENNETH HALLOWS; | 2025-12-17 |
| 65 | Description of Renal Involvement in Wilson’s Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Wilson’s disease (WD) is a rare genetic disorder that leads to copper accumulation in various tissues, including the liver, nervous system, heart, and kidneys. Renal involvement in WD has been poorly studied, and systematic screening is not currently recommended. Indirect renal complications are the most common, such as hepatorenal and cardiorenal syndromes, as well as severe complications like hemolysis or rhabdomyolysis. However, literature suggests that copper may exert a direct toxic effect on renal tubular cells, leading to both proximal and distal tubular dysfunction. These may manifest through often subtle signs, such as aminoaciduria, glycosuria, hypouricemia, … |
FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD | 2025-12-10 |
| 66 | The Practicality & Utility of Estimated Vs Measured Renal Function in Advanced Kidney Disease, Whether Treated With Dialysis or Not: Can Better Techniques Be Used to Predict The Onset of The Uraemic Syndrome and Guide Dialysis Requirements PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately measured in those already on dialysis. The main questions the study is trying to answer is whether measuring kidney function by clearance of iohexol is comparable to the current standard of care methods. In addition to routine care, … |
THOMAS LINDSAY; | 2026-03-04 |
| 67 | KINETIC — Kidney Transplant Improvement Through New Exercise Training to Increase Capacity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if a home-based exercise program can be safely and feasibly used to improve physical activity and physical function in adults waiting for a kidney transplant. The study will also learn how acceptable and useful this program is for participants. The main questions it aims to answer are: * Can a remote exercise program be delivered successfully to people on the kidney transplant waiting list? * Do participants follow the exercise program and wear a physical activity tracker as asked? * Is the program safe and well tolerated? Researchers will compare two groups to see if the exercise program leads to higher physical activity and better physical function: * Usual pre-transplant care with a physical activity tracker * Usual pre-transplant care plus an online exercise program Participants will: * Wear a wrist activity tracker to measure daily physical activity * Complete a one-week baseline period before being assigned to a study group * Be randomly assigned (like flipping a coin) to one of two groups * If assigned to the exercise group, take part in online exercise classes at home for 12 weeks with reminders and feedback, and then another 12 weeks without reminders and feedback * Answer questionnaires about their health, activity, and experience in the study This study may help researchers learn how to better support people waiting for kidney transplant through safe, home-based exercise programs. |
SARAH SCHRAUBEN; | 2026-03-03 |
| 68 | Bright Light Therapy to Treat Fatigue in End Stage Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to test light therapy in patients with end stage kidney disease who are receiving hemodialysis. The main aim is to determine if light therapy decreases fatigue severity. Participants will receive light therapy using special glasses for one hour during the dialysis sessions for four weeks of treatment. |
LEA ANN MATURA; | 2026-03-27 |
| 69 | Swedish Cardiac And Renal Failure Study-1 (SCARF-1): An Open-Label Pilot Trial to Evaluate The Feasibility, Safety and Efficacy of Eplerenone in Patients With Heart Failure With Reduced Ejection Fraction and Severe Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Previous studies have shown that patients with heart failure with reduced pumping function and preserved kidney function experience improved symptoms, longer survival, and fewer hospitalizations when treated with medications such as eplerenone. However, individuals with impaired kidney function have been excluded from these trials due to concerns about potential adverse effects on potassium levels, kidney function, and possibly also blood pressure. As a result, clear treatment recommendations for this high-risk group are lacking. In recent years, however, … |
CARL HAGGÅRD; | 2026-02-24 |
| 70 | A Prospective, Multicenter, Single-arm, Open-label, Non-randomized Exploratory Clinical Trial to Evaluate The Efficacy and Safety of Glomerular Filtration Rate (GFR-EPI) Using NEFRONIX in Patients With Chronic Kidney Disease (CKD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a prospective, multicenter, single-arm, open-label, non-randomized exploratory clinical trial designed to evaluate the safety and potential efficacy of an ultrasound stimulation device (NEFRONIX G-01) in patients with chronic kidney disease (CKD). Baseline functional assessments will be performed prior to intervention. Participants will receive ultrasound stimulation applied to the kidneys three times per week for four weeks according to the study protocol. Clinical evaluations will be conducted at baseline, at the end of treatment, … |
ANASONIC | 2026-01-15 |
| 71 | A Phase 2, International, Multicenter, Randomized, Double-blind, Parallel-group Trial to Evaluate The Efficacy and Safety of ABP-671 in Subjects With Chronic Kidney Disease and Hyperuricaemia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase 2, international, multicenter, randomized, double blind, parallel group trial to evaluate the efficacy and safety of ABP-671 in subjects with CKD and hyperuricaemia, to preliminarily evaluate the efficacy of ABP-671 in the treatment of subjects with CKD and hyperuricemia, primary Efficacy Endpoint is change in UACR from baseline to Week 28 |
ATOM THERAPEUTICS | 2026-01-07 |
| 72 | Effect of Canagliflozin on Ultrafiltration and Fibrosis in Peritoneal Dialysis: A A Proof-of-concept Randomized Phase II Crossover Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase II, proof-of-concept, placebo-controlled, double-blind, cross-over randomized clinical trial, assessing the effect of canagliflozin on peritoneal membrane function in patients on PD. The primary aim of this trial is to determine the short-term effects of canagliflozin, an SGLT-2 inhibitor, on glucose absorption by the peritoneal membrane and on ultrafiltration, as assessed by a standardized peritoneal equilibrium test. The secondary aims are to determine the effect of canagliflozin on solute clearance and on effluent biomarkers of inflammation, angiogenesis, and fibrosis at 26 weeks. We hypothesize that canagliflozin will prevent glucose absorption by the peritoneal membrane, … |
THOMAS MAVRAKANAS; | 2026-03-16 |
| 73 | Safety and Effectiveness of Tirzepatide(Spartina )in Chronic Kidney Failure A Single-center Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes management presents a complex clinical scenario marked by several challenges, especially in chronic kidney failure. These include navigating potential drug interactions between oral antidiabetic therapies and other agents. Furthermore, these patients may experience various adverse drug effects, such as lactic acidosis, electrolyte abnormalities such as hypomagnesemia, fluid retention, and lipid derangements, which can further augment overall morbidity. Consequently, many patients receive insulin. However, prolonged intensive insulin therapy may be linked to several adverse outcomes, including an increased risk of hypoglycemia and weight gain. Hence, … |
NOOSHIN DALILI; | 2025-12-15 |
| 74 | Prognosis of Primary Aldosteronism: A Prospective Cohort Study PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Primary aldosteronism (PA) is the most common cause of secondary hypertension, and patients with PA have a significantly higher risk of developing cardiovascular and renal complications compared with those with essential hypertension. However, PA remains substantially underdiagnosed and undertreated in clinical practice, and relevant research data on the short-term and long-term prognosis of PA patients in the Chinese population are particularly scarce. This is a multicenter, prospective cohort study designed to systematically collect real-world clinical data of PA patients, including baseline clinical characteristics, etiological subtypes, diagnostic and therapeutic strategies, and long-term follow-up outcomes. Through 5 years of standardized follow-up, … |
XIANG XIE; | 2026-02-03 |
| 75 | Registry of Daprodustat in Chronic Kidney Disease (CKD) Anemia for Understanding Real-World Evidence (REDCURE) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A local registry on CKD-associated anemia aims to provide real-world insights into disease burden, treatment patterns, and outcomes at the national level. It helps capture variations in anemia severity with CKD stages, therapeutic practices and their response. It also supports evidence-based decision-making, identifies gaps in care, and informs locally relevant guidelines and policy planning to improve patient outcomes with oral novel therapy i.e. daprodustat |
NABIQASIM INDUSTRIES PVT | 2026-01-20 |
| 76 | Markers of Nephrotoxicity During Treatment With Antibiotic Combinations: A Pragmatic Clinical Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Hospitalized patients with suspected or confirmed infection are commonly treated with vancomycin (VN) in combination with either piperacillin-tazobactam (PT) or cefepime (CP). Although these regimens have similar effectiveness, recent observational evidence suggests they may differ in terms of the risk for acute kidney injury (AKI). Interpretation of existing evidence is complicated by the limitations of creatinine, the standard biomarker used to monitor kidney function, which has poor sensitivity and specificity for drug induced AKI. To address this important knowledge gap, the investigators propose to conduct a pragmatic, open-label, … |
TODD MIANO; | 2026-02-13 |
| 77 | Comparing Effect of Intradialytic Aerobic Exercise Versus Incentive Spirometer on Fatigue and Sleep Quality Among Hemodialysis Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In order to accomplish the objectives of this investigation, a single-blind experimental comparative design was implemented to evaluate the impact of intradialytic aerobic exercise and Incentive Spirometer on sleep quality and fatigue. Three experimental groups (aerobic exercise and Incentive Spirometer) and one control group were subjected to pre- … |
HAIDER ATHAB MOHAMMED; | 2026-02-04 |
| 78 | The Effect of Differences in Intradialytic Eating Time on Hemodynamic Stability and Hemodialysis Adequacy in Patients With Chronic Kidney Disease Undergoing Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to examine how different meal timing during hemodialysis affects blood pressure stability and dialysis effectiveness in patients with chronic kidney disease. Many patients eat during hemodialysis sessions to maintain their nutritional status, but eating during treatment may affect blood pressure and the body’s ability to remove toxins and excess fluid effectively. At present, … |
TUTUT SETIOWATI; | 2026-03-11 |
| 79 | Randomized Trial of Sodium-glucose Cotransporter 2 Inhibition in Heart Transplant Recipients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Heart transplant (HTx) is an established therapy for advanced heart disease that restores quality of life and improves survival. However, due to preexisting comorbidities combined with the immunosuppressive therapies required after transplantation, HTx recipients remain at high risk for kidney, cardiovascular (CV), and metabolic disease. Large randomized clinical trials have recently shown that sodium-glucose cotransporter 2 inhibitors (SGLT2i) have potent kidney protective and CV benefits in many populations of patients with chronic kidney disease (CKD), CV disease and/or diabetes. SGLT2i have not been studied prospectively in HTx recipients, … |
JOSEF STEHLIK; | 2026-01-22 |
| 80 | A Single-Center, Prospective, Open-Label, Self-Controlled Clinical Study on The Efficacy and Safety of Amino Acid (15) Peritoneal Dialysis Solution in Improving Nutritional Status in Peritoneal Dialysis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to assess whether Amino Acid (15) Peritoneal Dialysis Solution can improve the nutritional status of adults with end-stage kidney disease who have received peritoneal dialysis for 6 months or longer. It will also observe the solution’s effects on dialysis adequacy and peritoneal transport function, … |
WEN XUE; | 2026-01-27 |
| 81 | Predictive Value of The Combination of Uric Acid/Albumin Ratio and Lactate for Acute Kidney Injury, Hemodynamic Support Requirement, and Mortality in Patients With Sepsis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection and remains a leading cause of morbidity and mortality in intensive care units. Early identification of patients at high risk for adverse outcomes is essential for timely intervention and improved prognosis. This prospective, single-center, … |
İLKE DOLGUN; | 2026-01-13 |
| 82 | Evaluating The Impact of Pre-Hospital Angiotensin Receptor-Neprilysin Inhibitor (ARNI) Therapy on Short-Term Clinical Outcomes in Heart Failure Patients With Reduced Ejection Fraction: A Comparative Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before hospital admission affects short-term health outcomes. The study will compare two groups of participants: those who were already taking ARNI before coming to the hospital and those who were not. Information will be collected from medical records during the hospital stay, including heart-related events, kidney-related events, … |
MRWAN AYMAN AHMED EASSA; | 2026-01-16 |
| 83 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ANGPTL3 Inhibition With Either Small-Interfering RNA Alone or in Combination With An ANGPTL3 Antibody in Participants With Diabetic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is researching experimental drugs called ALN-ANG3 and evinacumab (called study drugs). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times |
REGENERON PHARMACEUTICALS | 2026-03-17 |
| 84 | An Exploratory Study of REGEND003 Kidney Progenitor Cells on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: REGEND003, which consists of human kidney progenitor cells, demonstrates promising potential in repairing kidney injury. The purpose of this study is to assess the saftey and tolerability of REGEND003 on patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease. It is an exploratory study with multi-centered, randomized, controlled, single-blinded, dose-escalated designs. |
REGEND THERAPEUTICS | 2026-03-17 |
| 85 | Perioperative Risk Assessment of Acute Kidney Injury Related to Pulmonary Endarterectomy Under Deep Hypothermic Circulatory Arrest PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to assess the perioperative risk factors for acute kidney injury (AKI) in patients undergoing pulmonary endarterectomy (PEA) with deep hypothermic circulatory arrest (DHCA). By analyzing retrospective data (2016-2025) from approximately 240 PEA patients and prospectively enrolling 44 patients (2025-2027), we will identify clinical risk factors, establish and validate a comprehensive prediction model, and explore the dynamic characteristics and predictive value of novel biomarkers (e.g., NGAL, KIM-1). The goal is to improve early warning and management of PEA-related AKI, thereby enhancing patient outcomes. |
LI FANG WANG; | 2025-08-22 |
| 86 | Early Optimization of Ceftazidime Regimen in Critical Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Hospital-acquired infections, most of which are caused by Gram-negative bacteria, are common in intensive care units and have a major impact on patient prognosis. Patient survival in severe sepsis and septic shock depends on the early administration of appropriate antibiotic therapy, with mortality increasing by 7.6% for each hour of delay, justifying the probabilistic use of broad-spectrum antibiotics such as ceftazidime, an essential betalactamine, particularly used for its activity against Pseudomonas aeruginosa, a frequent pathogen in nosocomial infections. It is currently recommended that ceftazidime should initially be administered as a 2g loading dose, followed by maintenance treatment by continuous infusion, … |
CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE | 2025-11-24 |
| 87 | Finerenone for Cardiorenal Protection in Diabetic CKD: Impact on Renal Function Decline and Heart Failure PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To assess the effect of Finerinone on slowing renal function decline and improving cardiovascular outcomes, particularly heart failure risk, in patients with diabetic CKD. |
MUHAMMAD AWAIS DANISH; | 2026-01-08 |
| 88 | Impact of Diabetes-Related Metabolic Derangements on Clinical Outcomes in Hospitalized Patients With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study will collect clinical and laboratory information from hospitalized patients with chronic kidney disease to identify diabetes mellitus and selected metabolic findings during hospitalization |
MOHAMED MAHMOUD RASHAD; | 2026-01-21 |
| 89 | Screening for Subclinical Atherosclerosis in Diabetic CKD Using Carotid Doppler PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is being done at Assiut University to look for early signs of hardening of the arteries (atherosclerosis) in people who have both diabetes and chronic kidney disease (CKD). Many patients with these conditions are at higher risk of heart disease and stroke, but the disease can develop quietly without symptoms. We will use a safe, non-invasive test called carotid Doppler ultrasound, which uses sound waves to check the neck arteries (carotid arteries) for early changes. The goal is to see how often these early changes occur in patients with diabetes and CKD, … |
ABDALLAH ALI MOHAMMED; | 2025-12-05 |
| 90 | Individual and Combined Endothelin Receptor and SGLT2 Antagonism in Adults With Type 1 Diabetes Mellitus and Chronic Kidney Disease: A Phase 2, Multicenter, Open-label Randomized Cross-over Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to test the hypothesis that dapagliflozin (SGLT2 inhibitor) and SC0062 (ERA) combination therapy augments nephroprotection and mitigates fluid retention and ketogenesis in people with T1D through complementary and synergistic mechanisms of actions. |
HIDDO J LAMBERS HEERSPINK; | 2025-10-07 |
| 91 | Prognostic Value of Continuous Intra-abdominal Pressure (CIAP) and Continuous Abdominal Perfusion Pressure (CAPP) Monitoring for Acute Kidney Injury (AKI) Prediuction in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn whether high abdominal pressure or low blood flow pressure to the kidneys is linked to kidney injury after heart surgery. The main questions it aims to answer are: Does high abdominal pressure increase the risk of kidney injury after cardiac surgery? Can low blood flow pressure to the kidneys help predict who may develop kidney problems? Participants in this study are adults undergoing heart surgery, … |
MANU MALBRAIN; | 2025-07-25 |
| 92 | Increasing Equity in Live Donor Kidney Transplantation Through Effective Patient-Provider Communication PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to understand the communication occurring between Black and Caucasian patients and their transplant providers during transplant evaluation consultations and assess relationships between these communicative elements and patient and provider factors, patient-reported outcomes and living donor transplant outcomes – living donor referrals, evaluations, … |
HEATHER GARDINER (TRAINO); | 2025-07-24 |
| 93 | Effect of SGLT2 Inhibitors On Anemia in Patients With Chronic Kidney Disease (CKD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: anemia is a common complication of CKD patients and affect the quality of life and increase morbidity and mortality. managing anemia in CKD patients remains challenging conventional therapy including iron and ESAs which has its complications. the SGLT2 inhibitors have emerging evidence from major clinical trials in improving anemia in patients with CKD |
ROMANY NAGEB; | 2026-01-14 |
| 94 | Respiratory Biofeedback Added to Strengthening Training in Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether diaphragmatic biofeedback added to respiratory muscle training improves clinical and functional outcomes in adults with chronic kidney disease. It will also evaluate the feasibility and acceptability of this intervention. The main questions it aims to answer are: Is diaphragmatic biofeedback added to respiratory muscle training acceptable and well tolerated in patients with chronic kidney disease? Does this intervention reduce respiratory symptoms and complications in this population? Does diaphragmatic biofeedback added to respiratory muscle training improve cardiorespiratory capacity and quality of life? Researchers will evaluate diaphragmatic biofeedback combined with respiratory muscle training and a placebo intervention based on conscious breathing to assess its effects. Participants will: * Perform the assigned intervention three times per day for 6 weeks * Follow a structured respiratory muscle training program with diaphragmatic biofeedback * Be monitored for symptoms, respiratory complications, and perceived quality of life throughout the study |
MARIE CARMEN VALENZA; | 2026-01-27 |
| 95 | The Role of Triglyceride-glucose Index As A Predictive Marker for Insulin Resistance in Pre Diabetic Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the role of the triglyceride-glucose (TyG) index as a predictive marker for insulin resistance in pre-diabetic patients with chronic kidney disease (CKD), and to investigate its potential utility as a simple, non-invasive alternative to traditional insulin resistance assessment methods. |
EMAN OSAMA AHMED ABD_ELSAMEA; | 2025-12-12 |
| 96 | C3 Glomerulopathy Patient Characteristics and Treatment Response to Iptacopan in Routine Care: Analysis of Medical Charts (CHART-C3G) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a non-interventional chart abstraction cohort study with longitudinal follow up. Patients with C3G treated with iptacopan will be enrolled and characterized (i.e., systematically describe and summarize) regarding their medical history and iptacopan use and evaluated for clinical events, outcomes, and laboratory measurements upon and after iptacopan treatment initiation. Medical charts will be used to obtain secondary pseudonymized patient-level data with reference to 2 time anchors: at index date (date of iptacopan treatment initiation) with baseline covering 12 months prior to index date, … |
NOVARTIS PHARMACEUTICALS | 2026-01-09 |
| 97 | A Randomized, Open Label, Active-controlled, Parallel-group, Multi-center Study to Evaluate Efficacy and Safety of QLG1218(Daprodustat) in Chinese Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is to evaluate the efficacy and safety of QLG1218(daprodustat) following a switch from erythropoiesis-stimulating agent (ESA) in Chinese HD subjects with renal anemia who are currently treated with ESA. The primary objective is to demonstrate non-inferiority of QLG1218 to darbepoetin alfa. This study is a randomized, open Label, active-controlled, parallel-group, multi-center Study. The total duration of the study will be approximately 32 weeks including screening and follow-up. |
QILU PHARMACEUTICAL | 2025-12-23 |
| 98 | Validation Test for Plasma Oxalate Level in A Biochemical Laboratory at The Galilee Medical Center PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Elevated plasma oxalate levels in various conditions, including: primary hyperoxaluria due to increased production in the liver, renal failure due to decreased renal excretion, intestinal diseases with fatty diarrhea due to increased intestinal absorption, and increased intake of substances containing oxalate or sources of oxalate. Primary hyperoxaluria type 1 is a rare hereditary disease in which there is an increase in oxalate production in the liver due to a defect in the AGT enzyme in the oxalate metabolism pathway. The disease causes end-stage renal failure, and until recently, … |
HADAS SHASHA-LAVSKY; | 2025-12-30 |
| 99 | An Early-Phase Study of AZD0120 (Also Known As GC012F), A Chimeric Antigen Receptor-T Cell (CAR-T) Therapy Targeting CD19 and B Cell Maturation Antigen (BCMA), for Desensitization in Highly Sensitized Participants With End Stage Kidney Disease Awaiting Kidney Transplant PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the safety, tolerability, and efficacy of AZD0120 in highly sensitized adult participants with ESKD awaiting kidney transplant-who, as assessed by investigators, are improbable desensitization through conventional treatments (e.g., plasmapheresis and immunoadsorption)- with or without living donors. |
GANG CHEN; | 2026-01-23 |
| 100 | A Virtual Community-Based Digital Intervention for Prediabetes Management in China PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Individuals with prediabetes are at high risk for developing type 2 diabetes mellitus (T2DM) and are therefore prone to serious complications such as stroke, kidney failure, blindness, and lower-limb amputation. Prediabetes can be reversed, and lifestyle modification is considered the most effective intervention for diabetes prevention. However, … |
XILING HU; | 2026-01-14 |
| 101 | A Phase Ib/II Clinical Study to Evaluate The Efficacy, Safety, and Pharmacokinetics of TQB2934 for Injection in Subjects With Systemic Light Chain Amyloidosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a clinical trial aimed at the marketing of TQB2934 for injection. The project plans to enroll 70 subjects, including 13-21 subjects in Phase Ib, to evaluate the safety and preliminary efficacy, pharmacokinetic (PK) characteristics, immunogenicity, and pharmacodynamic (PD) of TQB2934 for injection in subjects with systemic light chain amyloidosis, and to determine the recommended Phase II dose (RP2D). The Phase II plan involves enrolling 49 subjects, aiming to demonstrate that in adult subjects with relapsed/refractory systemic light chain amyloidosis who have previously received treatment with daratumumab and bortezomib, … |
SHANGHAI CHIA TAI TIANQING PHARMACEUTICAL TECHNOLOGY DEVELOPMENT | 2026-01-02 |
| 102 | Effect of Hand Massage on Chronic Kidney Disease Associated Pruritus in Patients Receiving Hemodialysis: A Mixed Methods Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Kidney Disease-Associated Pruritus (CKD-aP) affects about 25% of Swiss hemodialysis patients, most with moderate to severe itching. It negatively impacts sleep, quality of life, and survival. This mixed-methods study will investigate the effect hand massage delivered by nurses on the itch severity, health-related quality of life and sleep compared to usual care in patients on hemodialysis. Fifty-four patients will be randomized to receive either hand massage or verbal attention over three months. Quantitative data (NRS, 5D Itch Scale, KDQOL-SFv1.2) will be collected at baseline, one, and three months. Qualitative interviews with 12 participants who received the hand massage intervention, … |
NANCY HELOU; | 2026-03-16 |
| 103 | STOP-PKD: SGLT2-inhibition to Improve Prognosis in Polycystic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Autosomal dominant polycystic kidney disease is the most common genetic cause of kidney failure. The only approved treatment for ADPKD – tolvaptan – is limited in its use by massive therapy-associated polyuria. This trial tests if the SGLT2-inhibitor dapagliflozin slows down the loss of kidney function in ADPKD. |
ROMAN MÜLLER; | 2026-02-27 |
| 104 | Comparison of Individualized Sodium Management Versus Standard Treatment in Hemodialysis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The SODIAH study is designed with the aim to assess the impact of isonatremic dialysis on interdialytic weight gain, fluid status, intradialytic hemodynamic stability, and incidence of intradialytic morbid events in dialysis patients. The study will be comparing the Na management option on the 6008 HD dialysis machines with the same machine without the Na management option turned on. Relevant performance and clinical data will be collected as well as information on patients’ quality of life and wellbeing. |
MARTIN JIROVEC; | 2025-12-22 |
| 105 | Rubix LS DKD Equity Registry (RUBIX-DKD): A Prospective Observational Patient Registry to Characterize Diabetic Kidney Disease Trajectories, Treatment Patterns, and Outcomes in Underserved Communities and to Enable A Future Embedded Phase IV Pragmatic Study PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetic kidney disease (DKD) is a common complication of type 2 diabetes that can lead to kidney failure and increases the risk of cardiovascular disease. This prospective, observational patient registry will follow adults with type 2 diabetes and DKD who are receiving routine clinical care at participating sites, with intentional enrollment from underserved communities. Health information will be collected from medical records and brief questionnaires (including social and access factors) for up to 24 months to understand DKD progression, real-world treatment patterns, and outcomes. This study does not assign any treatment. With participant consent and appropriate privacy safeguards, … |
REGINALD SWIFT; | 2026-01-16 |
| 106 | Effect of Probiotic Supplementation on Resistant Anaemia to Erythropoietin in Chronic Kidney Disease Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to assess whether probiotic supplementation can improve the hematological response of CKD patients to erythropoietin therapy and prevent or reduce erythropoietin resistance. The main questions it aims to answer are: Can probiotic be used as an adjuvant strategy in anemia management and increasing ESA responsiveness in CKD? What medical problems do participants have when taking probiotic? Researchers will compare Erythropoietin only with Erythropoietin + Probiotic to see if Probiotic aids in treating anaemic chronic kidney disease patients. Participants will: Take Erythropoietin + Probiotic or Probiotic only every day for 3 months Visit the clinic once every 4 weeks for checkups and tests Keep a diary of their symptoms |
EMAN SAID SAWAN; | 2025-12-22 |
| 107 | A Randomised, Double-blind, Placebo-controlled Trial With An Open-label Extension to Assess The Pharmacokinetics, Safety, and Efficacy of Empagliflozin Tablets in Paediatric Patients With Chronic Kidney Disease (EMPA-KIDNEY® Kids) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is open to children aged 2 to 17 with chronic kidney disease (CKD). The purpose of this study is to find out if a medicine called empagliflozin helps children and adolescents with CKD. Other goals of the study are to find out how empagliflozin is tolerated and handled by the body in children and adolescents with CKD. Participants are put into 2 groups randomly, … |
BOEHRINGER INGELHEIM | 2026-04-02 |
| 108 | Simulated Hypoxia Training to Enhance Exercise Tolerance in Stage 3 Chronic Kidney Disease: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic kidney disease (CKD) leads to poor exercise tolerance, vascular dysfunction, and reduced quality of life. This randomized controlled trial will compare intermittent hypoxic training (IHT) with traditional aerobic training in patients with CKD stages 3-4. A total of 60 participants aged 40-65 years will be recruited and randomized into three groups. Interventions will last 12 weeks, with three 30-minute supervised sessions per week. Outcome measures include exercise tolerance (6-Minute Walk Test), cardiovascular parameters (blood pressure, heart rate recovery), kidney function (serum creatinine, eGFR), fatigue (Fatigue Severity Scale), and quality of life (KDQOL-36) |
OLA MOHAMED ELSAYED ELGOHARY; | 2025-12-24 |
| 109 | The Effect of Origami Activities on Comfort Level and Quality of Life in Patients Undergoing Hemodialysis Treatment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study was conducted to evaluate the effect of origami activity on the comfort levels and quality of life of patients undergoing HD treatment. |
HELIN ATAY; | 2025-12-22 |
| 110 | A Phase IIb, Randomised, Multicentre, Double-Blind Study to Evaluate The Effect of Baxdrostat in Combination With Dapagliflozin Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: International, Multicenter and Double-Blind study. The purpose is to measure the effect of baxdrostat in combination with dapagliflozin compared with baxdrostat/placebo on albuminuria, as well as safety, in participants with chronic kidney disease and high blood pressure. |
ASTRAZENECA | 2026-04-03 |
| 111 | Prophylactic Hyperthermic IntraperitOneal Chemotherapy (p-HIPEC) for PRevention of PerItONeal Recurrence in Gastric Cancer: MC240402 (HORIZON) Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This phase II trial tests how well concentrating heated (hyperthermic) chemotherapy in the area that contains the abdominal organs (intraperitoneal \[IP\]) at the time of surgery works in treating patients with gastric or gastroesophageal junction adenocarcinoma at high risk of the cancer coming back to the abdominal cavity (peritoneal) after a period of improvement (recurrence). Recurrence in the peritoneum often occurs within the first 18 months after surgery. This is thought to be due to tumor cells that may scatter and spread during surgery. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, … |
TRAVIS E. GROTZ; | 2025-12-31 |
| 112 | A Randomized, Double-blind, Placebo-controlled, Parallel Group Phase 2a Study With An Extension Phase to Evaluate The Efficacy and Safety of BAY 3401016 in Participants Aged 18 to 45 With Alport Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Alport syndrome (AS) is a rare genetic condition that causes kidney disease, hearing loss, and eye abnormalities that occur due to changes in specific genes (COL4A3, COL4A4, and COL4A5). These genes help in producing an important protein called collagen. People with AS have a high risk of developing chronic kidney disease (CKD), a condition in which there is progressive loss in kidney function over time. The kidneys soon lose their ability to remove waste products from the body properly, … |
BAYER | 2025-11-05 |
| 113 | Impact of Intraoperative Oxygenation Practices on Patient Outcomes PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes. |
FREDERIC T BILLINGS IV; | 2025-12-03 |
| 114 | Domain-Specific Appendix: OXYGEN PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Our specific aims are to investigate whether conservative (≤30%), intermediate (50%), or liberal (80%) inspired oxygen during and immediately after surgery: Aim 1: Reduces surgical site infections (SSIs or wound infections) and other healthcare-associated infections (pneumonia and sepsis). Aim 2: Reduces a pooled composite of serious postoperative complications, leading to a faster and more complete recovery after surgery, … |
PAUL S MYLES; | 2025-09-25 |
| 115 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate The Effect of Orforglipron on The Incidence of Major Adverse Cardiovascular Events in Participants With Established Atherosclerotic Cardiovascular Disease And/or Chronic Kidney Disease PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to measure cardiovascular outcomes with orforglipron compared with placebo in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD). Participation in the study will last about 5 years. |
DANIEL VOGEL; | 2026-03-20 |
| 116 | Chronic Kidney Disease -Mineral and Bone Disorder, The CPH-MBD Cohort PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Persons with chronic kidney disease (CKD) have a 3-fold increased risk of bone fracture and a 10-fold increased risk of cardiovascular disease than the general population. These increased risks are related to the disturbances in the mineral metabolism, and this clinical entity is termed Chronic Kidney Disease – … |
FREJA STÆHR HASSAGER; | 2025-12-31 |
| 117 | A Study on The Eye-Brain-Kidney Interaction Mechanisms in Chronic Kidney Disease Based on Multimodal Magnetic Resonance Imaging PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the interaction between the eyes, brain, and kidneys in adult patients with Chronic Kidney Disease (CKD). The main question it aims to answer is: Do changes in the brain’s network connectivity and the retina’s blood vessels correlate with cognitive decline and kidney function in CKD patients? Participants with CKD who are already undergoing clinical care will complete cognitive tests and questionnaires, have non-invasive MRI scans of their brain and kidneys, and undergo non-invasive eye imaging (OCT/OCTA) of their retinas. |
BEIJING FRIENDSHIP HOSPITAL | 2026-01-27 |
| 118 | Finerenone and Cardiac Remodeling: A Randomized, Double- Blind, Placebo-Controlled Study to Evaluate The Effects of Finerenone on Ventricular Remodeling PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if the drug finerenone (Karendia) can improve heart function in participants who are at risk for heart and kidney disease. The main question it aims to answer is whether adding finerenone to standard-of-care heart failure medical therapies will beneficially alter the heart structure and function of people who have risk factors for heart and kidney complications and whose left side of the heart is enlarged. The researchers will compare finerenone to a placebo (a look-alike substance that contains no drug) to see if finerenone improves heart structure and function. Participants will: * take a finerenone or a placebo tablet once a day for 12 months * have a cardiac magnetic resonance imaging (cMRI; a safe, non-invasive scan to measure heart mass, stiffness and function) test at the beginning of the study and 12 months later * visit the clinic after one, three, six and twelve months to assess overall health and/or perform blood or urine tests |
SUBODH VERMA; | 2025-12-08 |
| 119 | Effect of Roxadustat on Heart Failure Patients With Anaemia and Moderate-to-Severe Chronic Kidney Disease: A Single-Centre Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Previous clinical observations of potential benefit from Roxadustat in this complex patient population prompted this investigation Therefore, the investigators designed this retrospective, observational study to thoroughly investigate the effects of Roxadustat on heart failure treatment and ventricular remodelling in this specific patient population, aiming to provide new insights for patients management. |
WENBIN LU; | 2025-12-08 |
| 120 | The Role of Complement in Diabetic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes is a chronic condition marked by long-term elevated blood glucose levels. There are more types of diabetes; the majority of patients have type 1 or type 2 diabetes. Over long period of time, high blood sugar damages blood vessels and organs. One of the most common complications is diabetic kidney disease, which can slowly lead to kidney failure. People with this condition also have a much higher risk of heart and blood vessel diseases. Newer research shows that the immune system, especially the complement system (a group of proteins that help defend the body), … |
MIODRAG JANIĆ; | 2026-02-23 |
| 121 | Equol Supplementation for Improving Vascular Function in Postmenopausal Women With CKD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function and elevated CVD risk. However, most of the literature in nephrology focuses on male patients, and studies on women’s vascular health are limited. Establishing effective therapies for improving vascular function and reducing CVD risk in women with CKD is a high research priority of the NIH. Equol contributes to improvement in vascular function, mediated in part by its anti-oxidative and anti-inflammatory properties. However, … |
UNIVERSITY OF COLORADO DENVER | 2025-09-26 |
| 122 | Targeting The Pathophysiology of Sickle Cell-Related Kidney Disease Using The SGLT2 Inhibitors, Empagliflozin PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Sickle cell anemia (SCA) is an inherited red blood disorder. The kidneys are among the most commonly affected organ systems in SCA. The Food and Drug Administration (FDA) has approved empagliflozin as a treatment to reduce the decline of kidney function in those with kidney disease. The proposed research study aims to determine whether empagliflozin can prevent the progression of kidney dysfunction in patients with sickle cell anemia (SCA) who are at high risk of developing advanced chronic kidney disease (CKD). |
SANTOSH L SARAF; | 2025-09-16 |
| 123 | A Randomized, Parallel, Two Arm Study Comparing The Net Clinical Benefit of Finerenone Versus A Fixed Dose Combination of Extended-Release Torsemide and Spironolactone in Patients With Hypertension and PRoteinuric ChrOnic KidNey Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A study Comparing the Clinical Benefit of Finerenone Versus a Fixed-Dose Combination (FDC) of Extended-Release Torsemide and Spironolactone in Patients with Hypertension and Chronic Kidney Disease. |
SOPHIA SHAH; | 2026-03-09 |
| 124 | A Randomized, Double-blind, Placebo-controlled, Multicenter Study of The Effects of Ganagliflozin on The Progression of Kidney Disease in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the impact of adding Ganagliflozin tablets to the current background therapy on preventing the progression of kidney disease in subjects with type 2 diabetes and chronic kidney disease. The efficacy and safety will be evaluated by comparing the effects of Ganagliflozin tablets and placebo tablets added to the current background treatment over 120 weeks |
HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL | 2025-11-18 |
| 125 | Clinical Performance of A Point-of-Care Creatinine Testing System in Individuals With Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical performance study is to evaluate the accuracy and usability of the Eaglenos Creatinine Test System（referred to as EG）, a point-of-care testing (POCT) system that consists of a handheld device and its associated creatinine test strips, … |
TINGTING XU; | 2025-11-26 |
| 126 | A Participant- and Investigator–Blinded, Placebo- Controlled, Randomized, Multipart, Single and Multiple Ascending Dose Study to Investigate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this first-in-human (FIH) study is to evaluate safety, tolerability, pharmacokinetic (PK) of OJR520. |
JULIET VENTO; | 2026-03-23 |
| 127 | The Effect of REgulation of PArathyroId HoRmone in Patients With Chronic Kidney Disease to Investigate The Change in Bone Mineral Density (Biskjoldbruskkirtelhormon Og Knogletæthed Hos Patienter Med Kronisk Nyresygdom) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The prevalence of chronic kidney disease (CKD) in the adult population is estimated to 10%. CKD increases risk of bone fractures, cardiovascular disease and death. The main role of parathyroid hormone (PTH) is to regulate mineral metabolism, including the calcium and phosphate homeostasis. PTH increases as the kidney function declines, and at end stage kidney disease almost all patients have disturbances in the mineral metabolism. Decreasing bone mineral density is associated with risk of fracture, both in background population and in patients with CKD. For decades, treatment with activated vitamin D, phosphate binders, … |
FREJA STÆHR HASSAGER; | 2026-01-06 |
| 128 | SIGNAL – Body Fluid Proteome SIGnatures for PersoNALised Intervention to Prevent Cardiovascular and Renal Complications in Diabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Title: Body fluid proteome SIGnatures for persoNALised intervention to prevent cardiovascular and renal complications in diabetes. Aim: To explore the feasibility of using urinary proteomic risk scores in clinical practice to identify patients at risk of developing end organ damage and identify which patients should receive additional renocardiovascular protective treatment. |
PETER ROSSING; | 2025-12-22 |
| 129 | Investigating The Impact of Finerenone on Retinal Vascular Dysfunction in Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Interestingly, A hypothesis-generating analysis was conducted from two studies using routine ophthalmological examinations from clinical trial participants (ReFineDR/DeFineDR), suggesting a potential benefit of finerenone in the delay of progression of non-proliferative diabetic retinopathy (NPDR), independent of baseline HbA1c. Potential benefits of finerenone were also observed in the prevention of required ocular interventions. However, the studies relied on routine ophthalmological examinations done retrospectively, which may have affected data quality and certainly affected quantity. Hence, there is a compelling need to conduct randomized studies with adequate power to detect a potential benefit of finerenone in delaying retinopathy progression, … |
MERNA ABOU KHATWA; | 2025-11-19 |
| 130 | A Phase 2a, Open-label, Single-arm Study to Evaluate The Efficacy, Safety, and Pharmacokinetics of VX-407 in Subjects With Autosomal Dominant Polycystic Kidney Disease Who Have A Subset of PKD1 Gene Variants PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to evaluate the effect of VX-407 on height-adjusted total kidney volume (htTKV), safety, tolerability, and pharmacokinetics (PK) of VX-407. |
VERTEX PHARMACEUTICALS | 2026-03-20 |
| 131 | Multimedia Health Education on Physical Fitness and Physical Activity for Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to determine whether a multimedia educational intervention can effectively improve physical fitness and physical activity levels in patients with chronic kidney disease (CKD), while also evaluating its overall outcomes. The study primarily seeks to answer the following questions: * Can multimedia education enhance CKD patients’ cardiorespiratory endurance, muscle strength, flexibility, … |
FU JEN CATHOLIC UNIVERSITY HOSPITAL | 2026-03-25 |
| 132 | An Exploratory Clinical Study on The Safety and Efficacy of Anti-CD19/BCMA Universal Chimeric Antigen Receptor T Cells in The Treatment of Relapsed/Refractory Immune-mediated Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19/BCMA U CAR T cell injection (KN3601) in patients with Relapsed/Refractory immune-mediated kidney disease |
CHANGHAI HOSPITAL | 2026-02-06 |
| 133 | CKD Awareness, Referrals, Education, and Support Intervention for Early-Stage CKD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pilot clinical trial is to learn if an intervention delivering education, motivational support, and social support can prevent worsening kidney disease in adults with diabetes and early-stage kidney disease. The main questions it aims to answer are: 1. Is this intervention feasible to deliver and acceptable to patients? 2. What is the impact of the intervention on patient motivation, self-efficacy, kidney disease knowledge, … |
UNIVERSITY OF ILLINOIS AT CHICAGO | 2025-10-07 |
| 134 | Transformative Research in Diabetic Nephropathy 2.0: A Proof of Principle Study of SGLT2 Inhibitors (TRIDENT 2.0) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn more about kidney health in adults with diabetic kidney disease and other groups. Researchers will study kidney tissue and other samples. They want to learn how sodium-glucose cotransporter-2 (SGLT2) inhibitors, a type of diabetes medicine, … |
KATALIN SUSZTAK; | 2026-03-02 |
| 135 | A Phase I Randomised, Single-blind, Placebo-controlled Study to Assess The Safety, Tolerability, and Pharmacokinetics of AZD1613 Following Multiple Ascending Dose Administration in Participants With Autosomal Dominant Polycystic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A study to investigate safety, tolerability, and pharmacokinetics of AZD1613 following subcutaneous or intravenous administration in participants with autosomal dominant polycystic kidney disease (ADPKD). |
ASTRAZENECA | 2026-03-12 |
| 136 | Safe Effective Therapy With Low-Dose Glucocorticoid in ANCA-Associated Vasculitis (SAFE-LOW) Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine the safety and efficacy of a therapeutic regimen consisting of 4 weeks of glucocorticoids given with a combination of the usual induction agents for ANCA-associated vasculitis. The trial will compare this regimen to the current standard of care treatment and glucocorticoid dosing for ANCA-associated vasculitis with severe kidney involvement. This trial will begin as a pilot to assess feasibility of recruitment and of adherence to the intervention. |
DAVID MASSICOTTE-AZARNIOUCH; | 2026-01-30 |
| 137 | Reliability of Muscle Strength and Activation Assessment Tools and Effects of An Online Therapeutic Exercise Program in Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research aims to evaluate the reliability and reproducibility of muscle strength and activation measurement tools, including isokinetic dynamometry and surface electromyography, in patients with chronic kidney disease (CKD). Additionally, the study will assess the feasibility and potential benefits of an online therapeutic exercise program supervised by physiotherapists. |
ALEJANDRO CAÑA PINO; | 2025-12-18 |
| 138 | Retrospective Chart Review of Safety Outcomes Associated With Use of Maribavir in Patients With Post-transplant Refractory Cytomegalovirus (CMV) Infection and Comorbid Severe Chronic Kidney Disease (CKD) or Comorbid End-stage Renal Disease (ESRD), Including Patients on Peritoneal Dialysis or Hemodialysis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main aim of this study is to assess the safety of maribavir in adults with severe CKD or comorbid ESRD including participants on artificial filtering of the kidney (dialysis) or the blood (hemodialysis). In this study, already existing data will be collected from the participant’s medical records. The study will only review data collected as part of the normal clinical routine and will not impact the standard medical care and treatment of participants. |
MAYA HITES; | 2025-12-16 |
| 139 | The Rutgers University Study of The Genetics of Kidney Disease PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn more about how genes impact the risk of kidney disease. Anyone 18 or older living in the US is eligible, and a diagnosis of kidney disease is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost. |
TARA MATISE; | 2025-11-03 |
| 140 | Prospective Multicenter Observational Study of The Management and Prognosis of Severe Acute Kidney Injury (AKI) in Nephrology Units: The French AKI Registry (FAKIR) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Acute Kidney Injury (AKI) is a common and serious condition in hospitalized patients, especially when it reaches stages 2 or 3 according to the KDIGO classification. These severe forms are associated with high mortality, a risk of progression to chronic kidney disease (CKD), and frequent cardiovascular complications. However, current data on how nephrologists manage these patients during hospitalization-and how these practices influence long-term outcomes-are limited and heterogeneous. The FAKIR study (French AKI Registry) is a prospective, multicenter, … |
UNIVERSITY HOSPITAL STRASBOURG FRANCE | 2025-08-14 |
| 141 | Evaluation of The Impact of A Mobile Application Developed for Hemodialysis Patients on Treatment Adherence, Symptom Management and Clinical Parameters PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effectiveness of a mobile health application developed for adult patients undergoing hemodialysis treatment. The mobile application includes modules on adherence to medication, diet, and fluid restrictions, symptom management (fatigue, pain, itching), nutrition guidance, exercise recommendations, and motivational content. It also features reminder notifications, an Ask the Expert module, and personal symptom tracking. The research will be conducted as a single-center, single-blind, randomized controlled experimental study. Participants will be assigned to intervention and control groups using block randomization. The intervention group will receive the mobile application, … |
İLKNUR PALAZ; | 2025-10-07 |
| 142 | Impact of Pleth Variability Index-Guided Acute Normovolemic Hemodilution on Intraoperative Fluid Management and Postoperative Complications in Cardiac Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Acute normovolemic hemodilution (ANH) is a widely used blood conservation strategy in cardiac surgery aimed at reducing intraoperative blood loss and the need for allogeneic blood transfusion. However, inadequate or excessive fluid replacement during ANH may lead to hemodynamic instability and other complications. The Pleth Variability Index (PVI) is a noninvasive dynamic parameter that can predict fluid responsiveness and guide goal-directed fluid therapy during surgery. This study aims to evaluate whether performing ANH under intraoperative PVI guidance in cardiac surgery allows more precise fluid management and reduces allogenic blood transfusion and the risk of perioperative complications. |
ERALP ÇEVIKKALP; | 2026-03-12 |
| 143 | A Randomized, Placebo-Controlled, Multicenter, Phase 1/2a Study to Investigate The Safety, Tolerability, and Pharmacokinetics of IGT-303 in Healthy Volunteers and Participants With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to observe the safety of IGT-303 in healthy volunteers and participants with Chronic Kidney Disease. The main question it aims to answer is: Is IGT-303 safe as a single dose or multiple dose regimen when applied under the skin (subcutaneously (SC)) or to a vein (intravenously (IV)). Researchers will compare IGT-303 against a placebo to see if IGT-303 is safe for use. Participants will be assigned to either IGT-303 or placebo and assessed for safety and tolerability for the duration of the study. |
EMMA TROWBRIDGE; | 2025-12-05 |
| 144 | Applications of MRI in Kidney Disease Related Papers Related Patents Related Grants Related Experts Highlight: This study has two major purposes: 1. To test developed multiple anatomic and functional MRI methods; 2. To evaluate the potentials of these MRI methods in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction. These purposes will be achieved by performing pilot studies with cohorts of patients. |
XIUFENG LI; | 2025-03-25 |
| 145 | Multifactorial Intervention to Reduce Cardiac and Renal Oxygen Need in Type 1 Diabetes (the MICRON Study) – A Steno 1 Substudy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to compare cardiac and renal oxygen consumption among subjects with type 1 diabetes treated with either multifactorial intervention or according to the current standard care. Participants are recruited from a main study /the Steno1 study) responsible for the intervention. The main questions it aims to answer are if a multifactorial intervention in subjects with type 1 diabetes targeting cardiovascular and renal risk factors, will reduce cardiac and renal oxygen demand. Participants will undergo the following examinations at 0-month, 6-month, … |
JAKOB A ØSTERGAARD; | 2026-02-02 |
| 146 | Cardiovascular Kidney and Metaboolic (CKM) Health Assessment and Patient Empowerment in ChROnic Disease Using A Health Coach INtervention ModEl: A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of CHAPERONE solution is to evaluate the efficacy of engaging, assessing, and enabling long term treatment strategy with Health Artificial Intelligence (AI) Chatbot, Copilot, Large Language Model (LLM) and vital sign monitoring device in reducing CKM disease burden using an algorithm obtained from biomarkers and diagnostics utilizing remote sensor driven technology tools, care coordination and patient empowerment. |
ZAKI LABABIDI PI; | 2026-02-12 |
| 147 | A Randomized, Sham-controlled Pilot Trial of A Novel Therapeutic Strategy (taVNS) for Autonomic Nervous System (ANS) Dysfunction in Chronic Kidney Disease (CKD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: 30 patients will participate in a prospective randomized clinical trial to test the safety, tolerability and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) for autonomic nervous system (ANS) dysfunction in the chronic kidney disease (CKD) stage 3-5 setting. |
QANDEEL SOOMRO; | 2025-12-31 |
| 148 | Randomized, Open Label Study to Examine The Outcomes of Physiologic Insulin Resensitization in Patients With Chronic Kidney Disease and Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research is to evaluate outcomes of physiologic insulin re-sensitization (PIR) in patients with Chronic Kidney Disease (CKD) and Type 2 Diabetes Mellitus (T2DM). |
SUNGCHUN LEE; | 2025-10-20 |
| 149 | Diagnostic Accuracy, Usability, Patient Compliance, and System Reliability of The AK+ Guard™ ECG Application for Hyperkalemia Prediction in Ambulatory Chronic Kidney Disease Patients (Outpatient and Remote Monitoring Arms) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational pilot study is to evaluate the investigational AK+ Guard™ software as a medical device (SaMD) for detection of moderate to severe hyperkalemia (serum potassium (K+) ≥ 6.5 mmol/L) in adults with chronic kidney disease (CKD). Study objectives are: * Arm 2A (Outpatient Diagnostic Accuracy): To generate a preliminary, real-world signal of the diagnostic performance of AK+ Guard™ when used in an ambulatory CKD cohort for identifying clinically significant hyperkalemia episodes (serum K+ ≥ 6.5 mmol/L) at the time of an outpatient laboratory draw. * Arm 2B (Remote Patient Monitoring): To assess participant compliance, usability, … |
ACCURKARDIA | 2025-10-16 |
| 150 | Standard Flank Approach Vs Supine Approach for Robot-assisted Partial Nephrectomy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to find out which surgical position is safer and works better for patients candidate to robot-assisted partial nephrectomy (RAPN) – a minimally invasive procedure to remove a small kidney tumor while preserving healthy kidney tissue. During this operation, the patient can be placed in two different positions: * the standard flank position, where the patient lies on their side * a newer supine position, where the patient lies on their back using a technique called Supine Anterior Retroperitoneal Approach (SARA). Both approaches are performed using the Da Vinci® Single Port (SP) robotic system, … |
PAOLO DELL’OGLIO; | 2025-11-21 |
| 151 | Telemedicine for Evaluation and Counseling of Living Kidney Donor Candidates PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this feasibility clinical trial is to learn if telemedicine can be used to provide education and evaluation and counseling for people who are considering living kidney donation. The study will also learn how participants improve decision-making about living kidney donation. The main questions to answer are: * Is telemedicine a practical way to facilitate donor education and evaluation and counseling? * Does telemedicine shared decision making help improve donor candidate decision and engagement during the donor evaluation process? Researchers will compare standard care with a telemedicine care coordination approach. Participants will: \- … |
FAWAZ AL AMMARY; | 2025-10-03 |
| 152 | Prospective, Non-Randomized, Multicenter, Open-Label Study Evaluating The Use of The Moda-flx Hemodialysis System™ Under Professional Care and At Home By Participants With End Stage Kidney Disease (ESKD) Who Are on Stable Dialysis Regimens PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety and efficacy of the Moda-flx Hemodialysis System™ when used Under Professional Care Settings by trained individuals and At Home by trained Participants and Care Partners |
DIALITY | 2025-11-10 |
| 153 | The Feasibility and Effects of Exercise Training Combined With Blood Flow Restriction Training on Exercise Capacity and Exercise Tolerance in Patients With Chronic Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in healthy and CKD patients |
KUN-LING TSAI; | 2025-12-17 |
| 154 | CLEOPATTRA: Effects of NNC6019-0001 Versus Placebo on Cardiovascular Outcomes in Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM) PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study will find out if a new medicine called NNC6019-0001 can help reduce the risk of heart-related death and illness in participants with a condition called transthyretin amyloid cardiomyopathy (ATTR-CM), which affects the heart. Participants will either receive NNC6019-0001 or a placebo (a treatment with no active medicine), and which one they get is decided by chance. Everyone in the study will continue receiving their usual heart treatments as recommended by their doctor. |
NOVO NORDISK | 2026-03-19 |
| 155 | Web-based Advance Care Planning Intervention for Patients With Kidney Failure on Dialysis: Pilot Testing of ‘My Voice’ PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: ‘My Voice’ is a website intervention developed to enable advance care planning (ACP) conversations for patients with kidney disease on dialysis, educate patients on their illness, help identify their goals and preferences for EOL care, and coaches them on how to speak with their HCPs and loved ones. This study aims to evaluate if ‘My Voice’ intervention improves quality of ACP conversations between patients and providers, and patients and family carers; improves patient’s knowledge about kidney failure, engagement in ACP and preparedness for future end of life care compared to usual practices for ACP in dialysis centres. |
CHANDRIKA RAMAKRISHNAN; | 2025-12-30 |
| 156 | Base De DOnnées Cliniques Et Biologiques Harmonisées Pour Une REcherche Intégrée À La Prise En Charge Des Leucémies Aiguës Myéloïdes Pédiatriques PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this project is to study the different diagnostic, predictive, and prognostic profiles, as well as their interrelationships (clinical, biological, genetic) in children with Acute Myeloid Leukemia (AML). Despite numerous research projects on separate cohorts, the prognosis for pediatric AML has not improved. The project therefore consists of pooling research data and existing clinical and biological data from healthcare in a health data warehouse to increase its power. As these diseases are rare and genetic subgroups even rarer, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-09-02 |
| 157 | Use of NAD Oxidase Modulation Agent QRX3 for Prevention and Treatment of Progressive Chronic Kidney Disease PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic kidney disease CKD is estimated to affect nearly over 800 million people globally today (with roughly 125,000 people ending up annually on dialysis in the United States alone. CKD is a contributor to illness and is associated with a diminished quality of life and reduced life expectancy . In this study the investigators are using a novel drug to target improved function of the kidneys. |
EBIMA CLIFFORD OKUNDAYE; | 2025-09-08 |
| 158 | Use of Vasopressin in Septic Shock PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this observational study is to examine real-world clinical practice regarding the use of vasopressin as a second-line vasopressor in adult patients admitted to Intensive Care Units (ICUs) with septic shock. The study focuses on critically ill adults (≥18 years) diagnosed with septic shock and treated with norepinephrine and vasopressin. The main research questions are: * Does early initiation of vasopressin-defined by the norepinephrine dose at the time of introduction-reduce mortality in patients with septic shock? * What is the impact of vasopressin as a second vasopressor on renal function and the progression of organ dysfunction in septic shock patients? Participants will: * Be admitted to an ICU with a diagnosis of septic shock. * Receive vasopressin as an adjunct to norepinephrine for hemodynamic support. * Be monitored daily throughout their ICU stay, with data collected through a dedicated REDCap system. * Have relevant clinical data pseudonymized and incorporated into the study database for statistical analysis. |
JAMIL CEDEÑO MORA; | 2025-12-15 |
| 159 | Effects of Surgical, Percutaneous or Medical Treatments for Coronary Artery Disease on Renal Function: Long-Term Outcome. Cardiorenal-trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Coronary artery disease (CAD) is treated with coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or optimized medical therapy (OMT). Their cardiovascular outcomes are well studied, but renal effects remain unclear. Objective: To evaluate long-term renal outcomes of different CAD treatment strategies. Methods: In this retrospective cohort from the MASS registry, patients with stable multivessel CAD and preserved ventricular function underwent OMT, CABG, or PCI. Annual creatinine was measured for ≥5 years, and eGFR calculated using CKD-EPI. The primary endpoint was change in renal function over time. Secondary endpoints included new-onset CKD, progression to advanced CKD, dialysis, … |
EZIO DE MARTINO NETO; | 2025-09-29 |
| 160 | The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 1) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary research objective of the project is to determine the role of eGC in microvascular reactivity in CKD (cross-sectional study 1). The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CKD, as well as identify new biomarkers for CKD. |
INES DRENJANCEVIC; | 2026-03-02 |
| 161 | External Validation and Recalibration of Heart Failure Risk Models (MAGGIC, GWTG-HF, and SHFM) in Egyptian Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Heart failure (HF) affects over 64 million people worldwide and carries high morbidity, frequent hospitalizations, and major economic burden. Accurate risk stratification is essential to guide therapy, follow-up, and advanced care decisions. Several prognostic models have been developed: MAGGIC: based on \>39,000 patients, predicts mortality from simple clinical variables. GWTG-HF: derived from \>30,000 patients, predicts in-hospital mortality using admission data. SHFM: estimates 1-3 year survival, incorporating clinical, lab, and treatment factors. These models, developed mainly in Western cohorts, may not perform well in Arab populations, where HF patients are younger, with more ischemic disease, diabetes, CKD, … |
ANTONIOUS GAMAL; | 2025-10-01 |
| 162 | The Association Between Dietary Pattern and The Progression of Chronic Kidney Disease in Patients With Type 2 Diabetes Mellitus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the relationship between dietary patterns and the progression of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus. |
MARIAM EMEEL HALEEM NASEEM; | 2025-09-12 |
| 163 | Validation of The STARZ Score for Early Prediction of Neonatal Acute Kidney Injury in Assuit University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Neonatal acute kidney injury (AKI) is a common complication in the NICU, associated with high morbidity and mortality. Prematurity, low birthweight, sepsis, asphyxia, congenital heart disease, and nephrotoxic drugs are major risk factors. Early diagnosis is challenging as serum creatinine lacks sensitivity. The STARZ score, a composite clinical-laboratory tool, has shown high accuracy for predicting early neonatal AKI. This study aims to validate the STARZ score in neonates admitted to Assiut University Children’s Hospital for early identification of AKI and improved clinical outcomes. |
MENNA ALLAH TALAAT MAHMOUD; | 2025-10-02 |
| 164 | Viscoelastic Tests (VET) Versus Conventional Coagulation Tests (CCT) for Management of Trauma-Induced Coagulopathy: Opened, Randomized, Two-Parallel, Controlled Trial.VISCOTAC PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic coagulopathy is a complex, multifactorial event that occurs in 20-30% of patients on admission. It increases mortality, and its treatment is one of the main priorities in the early management of severely injured patients. Diagnosis of coagulopathy has traditionally been based on conventional coagulation tests (CCTs), which provide an assessment of patients’ coagulation in over 60 minutes. Over the past fifteen years, viscoelastic tests (VETs) have been proposed, providing a more rapid result (≤ 10 min) and can guide the administration of labile blood products (LBP). Various studies, mainly retrospective, … |
GUILLAUME BOUHOURS; | 2025-07-11 |
| 165 | Hyperuricemia As A Predictor of Chronic Kidney Disease (CKD) Progression in Prediabetic Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic kidney disease (CKD) is a major global health problem, and hyperuricemia has emerged as both a consequence and a potential driver of its progression. Elevated uric acid contributes to renal impairment through oxidative stress, endothelial dysfunction, inflammasome activation, and crystal deposition. Epidemiological studies show that hyperuricemia often precedes CKD and serves as an independent predictor, with prevalence reaching up to 38% among CKD patients. Prediabetes, another growing health concern, is associated with higher serum uric acid levels and increased risk of developing both diabetes and CKD. Factors such as obesity, fatty liver, and dyslipidemia mediate this link. Clinically, … |
SHERRY REFAAT; | 2025-09-30 |
| 166 | THE USE OF POTASSIUM-RICH SALT SUBSTITUTES IN BLOOD PRESSURE CONTROL OF KIDNEY TRANSPLANT RECIPIENTS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Excessive sodium intake and inadequate potassium intake in the diet are known risk factors for the development of arterial hypertension and an increased risk of cardiovascular events. Data from randomized controlled trials show that the use of salt substitutes with reduced sodium and increased potassium content represent an effective way to reduce dietary sodium intake, … |
TANJA BELČIČ MIKIČ; | 2025-09-17 |
| 167 | Community-based Diet Intervention for Kidney Health in Black Americans PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine the feasibility and acceptability of a16-week diet coaching program enhanced with cooking classes to improve adherence to the Dietary Approaches to Stop Hypertension (DASH) diet among adults who are at risk for developing chronic kidney disease. |
CRYSTAL TYSON; | 2026-01-15 |
| 168 | Supporting VETerans With Kidney Disease Through Food As Medicine: The Community-based VET FAM Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pilot clinical trial is primarily learn if produce boxes improve clinical outcomes among Veterans with kidney disease and food or nutrition insecurity. Secondly, the study will capture Veterans qualitative perspectives, experience, and engagement through semi-structured interviews. |
LUIS M PEREZ; | 2025-10-01 |
| 169 | Obinutuzumab Induced Decreases of PLA2Rab in MN: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: To assess the disappearance rate (half-life) of anti-PLA2R antibodies in high-risk primary membranous nephropathy (pMN) patients treated with obinutuzumab (OBI), and to evaluate immunological and clinical remission, adverse events, and quality of life. Design: Open-label, single-center, prospective pilot intervention study conducted at Radboud University Medical Center. Population: 20 adult patients with high-risk PMN, defined by proteinuria ≥3.5 g/24h despite 6 months of supportive treatment with ACE inhibitors or ARBs. Intervention: OBI 1000 mg on days 1 and 15, … |
ANNE-ELS VAN DE LOGT; | 2026-01-06 |
| 170 | Efficacy and Safety of Folic Acid on Acute Kidney Injury in Adults: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the feasibility of folic acid supplementation as a treatment for adult patients with acute kidney injury (AKI) receiving hospital care. The main question it aims to answer is: Is it feasible to conduct a fully-powered randomized controlled trial (RCT) to assess the efficacy and safety of folic acid supplementation in AKI management? Researchers will compare two groups (usual care vs. usual care + 5 mg folic acid) to determine the feasibility of folic acid supplementation and estimate the sample size required for a fully powered RCT. Participants will: 1. Receive either usual care, or usual care combined with oral folic acid (5 mg daily) until AKI resolution (up to 30 days); 2. Undergo regular monitoring during hospitalization and follow-ups at 3 months and one year post-discharge. |
TIMOTHY H RAINER; | 2025-07-15 |
| 171 | Jaboticaba (Plinia Cauliflora) As A Strategy to Modulate Inflammation, Oxidative Stress, and Gut Dysbiosis in Patients With Chronic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The increase prevalence of chronic kidney disease (CKD) over the years represent a significant public health problem. The role of inflammation and oxidative stress in the pathophysiology of CKD, as well as progression and comorbidities, is already well consolidated. The gut microbiota composition imbalance may also be a risk factor contributing to the increased conditions mentioned above, and to uremic toxins release and endotoxemia. The literature has indicated the use of bioactive compounds as a nonpharmacological treatment strategies for the management of non-communicable diseases (NCDs), such as CKD and its complications. In this context, … |
DENISE MAFRA; | 2025-04-03 |
| 172 | Oxalate and Citrate in Humans – Response to Citrate PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person’s chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate. |
UNIVERSITY OF CHICAGO | 2025-12-16 |
| 173 | Patient-Centered Lab Result Communication Tool for Older Adults With Elevated Hemoglobin A1c (A1c) or Chronic Kidney Disease (CKD) Related Papers Related Patents Related Grants Related Experts Highlight: For adults \>65 years and their providers, the investigators will test the usability and design of a tool to replace standard uniform reporting of lab results to patients and their providers with a new personalized EHR lab result communication tool that: 1) extracts patient-level data from the EHR; 2) calculates individual risk; and 3) for patients with very low risk, communicates the individualized risk information. The investigators will employ a range of user experience research methods to understand how patient and provider users interact with the new lab result communication tool and to assess their comprehension of the lab results. |
CATHERINE A. SARKISIAN; | 2025-10-03 |
| 174 | Efficacy of Live Online Course Mindfulness Program on Perceived Fatigue in Hemodialysis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to assess the efficacy of a 2-month live online mindfulness meditation program in reducing perceived fatigue (measured by the SONG-HD Fatigue Scale) in patients undergoing chronic hemodialysis. The sponsor expects that a live online mindfulness meditation course will have a significant public health impact by reducing perceived fatigue, which is strongly associated with cardiovascular events, mortality, … |
MARINE NAUDIN; | 2025-07-08 |
| 175 | Measurement of Mass Change in Serum Albumin Compared to Serum Lactic Acid As Predictive Tool for Sepsis Prognosis in Non Surgical ICU Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to assess the reliability of measurement of mass change in serum albumin compared to serum lactic acid as predictive tool for sepsis prognosis in nonsurgical ICU patients |
AIN SHAMS UNIVERSITY | 2025-12-17 |
| 176 | Real-world Experience With Finerenone Treatment in Patients From India With Chronic Kidney Disease and Type 2 Diabetes-Retrospective Data Analysis PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Availability of this study’s data will later be determined according to Bayer’s commitment to the EFPIA/PhRMA Principles for responsible clinical trial data sharing. This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, … |
BAYER | 2026-03-11 |
| 177 | Impact of APP-assisted Patient Management on The Quality Control of Blood Purification Therapy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Many maintenance hemodialysis (MHD) patients develop negative outlooks due to their illnesses and complications, making their quality of life and prognosis a clinical concern. Effective life management and treatment cooperation are crucial to improving dialysis quality and patient outcomes. This trial aims to evaluate whether management through the Yueya mini-program and WeChat can provide personalized guidance such as health education, diet, exercise, medication supervision, and condition monitoring to enhance treatment compliance, quality of life, strengthen quality control in the hemodialysis unit, and improve patient prognosis. Patients will be divided into a group receiving support via the Yueya mini-program and WeChat, … |
YUNFENG XIA; | 2025-12-18 |
| 178 | Improving Deceased-Donor Kidney Transplant Outcomes Via A Single Intragraft Injection of C1 Esterase Inhibitor (RTB-021) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to find out if Berinert can improve kidney function in the first year after transplant and to find out what effects, good or bad, … |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2026-02-27 |
| 179 | An International, Multi-centre, Randomised Controlled Trial Co-designed With Consumers With Lived Experience of Peritoneal Dialysis (PD) to Determine The Optimal Approach to Starting Patients With Kidney Failure on PD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Kidney failure is fatal without dialysis. Peritoneal dialysis (PD) completed at home offers greater flexibility and autonomy for patients . However, PD is often prescribed for 24 hours/day, 7 days/week for every patient starting dialysis. This practice is not evidence-informed, may be unnecessary and potentially harmful. The STEP-PD trial aims to determine the optimal approach to commencing patients on PD through starting at low dose PD and incrementing over time. |
THE UNIVERSITY OF QUEENSLAND | 2026-03-19 |
| 180 | Focus on Levels of Awareness and Perceptions Regarding HsCRP in Identifying Systemic Inflammation in ASCVD, CKD and Heart Failure Management PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a survey-based study conducted among cardiologists and nephrologists treating people with Atherosclerotic Cardiovascular Disease (ASCVD), Heart Failure (HF) and Chronic Kidney Disease (CKD). Study participants will be recruited to complete self-administered online survey. The purpose of this research is to gather real-world evidence related to attitudes around systemic inflammation and specifically the awareness, perception, drivers and barriers, and use of hsCRP in clinical practice to identify systemic inflammation in people with ASCVD+CKD and HF. |
NOVO NORDISK | 2026-02-11 |
| 181 | Characterization of Renal Microvascular Alterations in Patients With Active Urinary Sediment And/or Proteinuria Using Ultrasound Localization Microscopy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is the non-invasive visualization and quantification of renal microvascular dynamics in adult kidneys with proteinuria and/or active sediment. |
FERDINAND KNIELING; | 2026-03-13 |
| 182 | Hamburg Acute Renal Injury Study PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The Hamburg Acute Renal Injury Study (HARIS) is a prospective observational cohort study aimed at investigating the mechanisms, risk factors, and clinical determinants of acute kidney injury (AKI) trajectories and consequences. |
TOBIAS B HUBER; | 2026-01-14 |
| 183 | A Phase 1, Open-Label, Single-Dose, Parallel Group, 2-Part Study to Evaluate The Pharmacokinetics of Bepirovirsen in Adult Participants With Severe or Moderate Renal Impairment Compared to Matched Healthy Control Participants PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a 2-part study where all participants will receive bepirovirsen. The study will measure how much bepirovirsen from a single dose gets into the blood, and how long it stays in the blood. The purpose of the study is to understand if blood levels of bepirovirsen are different in adults with kidney disease compared to healthy adults who do not have kidney disease. |
JESUS NAVARRO; | 2025-10-15 |
| 184 | Impact of Kremezin on Renal Recovery and Uremic Toxin Levels in Patients With Acute Kidney Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary goal of this clinical trial is to evaluate the efficacy of AST-120 (Kremezin®) in combination with standard care in reducing the levels of protein-bound uremic toxins (PBUTs), specifically indoxyl sulfate (IS) and p-cresyl sulfate (p-CS), in patients with acute kidney disease (AKD). The trial aims to assess whether AST-120 can prevent further renal deterioration and slow the progression from AKD to chronic kidney disease (CKD) by mitigating the accumulation of PBUTs. Additionally, the study will investigate the potential of AST-120 to reduce the risk of CKD-associated complications, including cardiovascular disease, by reducing PBUT levels in AKD patients. |
CHANG GUNG MEMORIAL HOSPITAL | 2025-09-19 |
| 185 | SCARR: Allogeneic Umbilical Cord Mesenchymal Stromal Cells for The Treatment of Chronic Antibody-Mediated Rejection (cABMR) in Kidney Transplantation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Kidney transplantation is the best treatment for end-stage chronic kidney disease (CKD), improving survival and quality of life, while reducing treatment costs. However, immunosuppressive therapies reduce acute rejection but have not significantly improved graft survival (60% at 10 years). Graft loss is largely due to chronic antibody-mediated rejection (cABMR), which remains a major challenge with no specific treatment. In our center, 20 cABMR cases confirmed by biopsy were identified in 2018-2019, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2025-06-26 |
| 186 | Risk Assessment of Postoperative Acute Kidney Injury and Personalized Intraoperative Hypotension Threshold Prediction Based on Blood Pressure Components in Non-Cardiac Surgery Patients PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: Postoperative acute kidney injury (AKI) is a serious complication often linked to low blood pressure during surgery. This study aims to better protect patients’ kidneys by personalizing how blood pressure is managed during an operation. The project has two main goals: First, researchers will analyze data from over 44,000 past surgeries to identify which specific blood pressure measurements are the most critical warning signs for kidney damage. Second, using this knowledge, they will build a smart tool (a machine learning model) to predict a unique, … |
LANYUE ZHU; | 2025-09-05 |
| 187 | Sensor-based Congestion Alert for Events in Peritoneal Dialysis (SCALE-PD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To explore the use of the Bodyport Cardiac Scale in predicting worsening of events due to fluid overload in patients with kidney disease on peritoneal dialysis. |
BODYPORT | 2026-03-18 |
| 188 | Premarket Clinical Safety Assessment of The ELISIO™-HX PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary safety objective of this study is to evaluate the safety of the use of the high-permeability hemodialyzer series ELISIO™-HX, by showing that the pre-dialysis albumin levels are not affected using the investigational dialyzer. The primary efficacy objective is to evaluate the performance of the use of the high permeability hemodialyzer series ELISIO™-HX, by showing that the clearance rate of middle molecular weight lambda (λ) free light chain (FLC) is improved by using the investigational dialyzer. |
KIRANJIT DHILLON; | 2026-03-06 |
| 189 | Sedation Practice in Intensive Care Evaluation (SPICE IV) Early Sedation With Dexmedetomidine Vs. Placebo in Older Ventilated Critically Ill Patients: A Prospective, Multi-Centre, Double-Blind, Randomized, Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Sedation remains a ubiquitous and crucial component of intensive care treatments in critically ill mechanically ventilated patients. Sedation relieves anxiety, reduces distress, and promotes tolerance of endotracheal intubation and associated life-sustaining interventions such as mechanical ventilation, cardiovascular assistance, and renal support. Thus, choosing the optimal sedative agent is vital to patient comfort, safety, and survival. Despite more than 20 years of intensive care sedation research, there is still no consensus on what constitutes best sedation practice. The Society of Critical Care Medicine, the premier critical care organisation in North America, … |
KIMBERLEY LEWIS; | 2025-09-10 |
| 190 | Multimorbidity and Cardiovascular Risk Factors After Renal Transplant PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Who can participate? Any adults over the age of 18 who have received a kidney transplant at the research centre are eligible for recruitment within the first month after transplant What does the study involve? The study involves observing and gathering data to understand how the health of people who receive a kidney transplant changes over the first year. In particular the investigators are interested in the risk factors for heart disease and stroke, and how these change over the first year of transplant. The investigators are also interested in multiple health conditions, … |
NICHOLAS SELBY; | 2025-10-03 |
| 191 | Study of The Impact of Time of Vaccination on Response to Influenza Vaccine in Patients With Chronic Renal Failure – CHRONOVAX 2 PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Immune response to influenza vaccine in patients with chronic renal insufficiency. |
GOSSET CLÉMENT; | 2025-09-11 |
| 192 | The Impact of Nurse Practitioner-Led Multidisciplinary Team Intervention on The Implementation of Guideline-Directed Medical Therapy and Clinical Outcomes in Adults With Multimorbidity: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether a nurse practitioner-led multidisciplinary team (NP-led MDT) intervention can improve the use of guideline-directed medical therapy (GDMT) and short-term clinical outcomes in hospitalized adults with multimorbidity in a multidisciplinary medicine ward. The main questions it aims to answer are: Does NP-led MDT intervention increase the proportion of patients achieving GDMT at hospital discharge? Does NP-led MDT intervention reduce 30-, 60-, and 90-day readmission, emergency department visits, … |
HSIAO-CHEN CHOU NURSE PRACTITIONER; | 2026-03-19 |
| 193 | Effect of Exercise in Patients With Chronic Kidney Disease: TONE Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group |
CASA DI CURA DOTT PEDERZOLI | 2026-02-27 |
| 194 | Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown. The investigators aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. In a cluster project the investigators assess the effect of vascular risk factor screening in an observational study as well as a cohort study. The project has two interlinked components: a prospective single group study, … |
JOHAN ZELANO; | 2026-03-03 |
| 195 | A Phase II Clinical Study to Evaluate The Efficacy and Safety of UBT251 Injection in Obese/Overweight Chronic Kidney Disease (CKD) Population PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This multicenter, randomized, double-blind, placebo-controlled phase II clinical study to evaluate the efficacy and safety of UBT251 injection in obese/overweight chronic kidney disease (CKD) population |
THE UNITED BIO TECHNOLOGY HENGQIN | 2025-11-25 |
| 196 | A Randomized, Placebo-controlled, Double-blind Phase 2b Trial to Assess The Efficacy and Safety of Ex Vivo Allograft Admin of ICM012 Solution 2 Mg/mL to Improve Allograft Function in Recipients of Donation After Circulatory Death Kidneys PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Randomized (1:1), placebo controlled, double blind efficacy trial. 200 patients will be followed up for 12 months post transplantation. The primary endpoint will be Delayed Graft Function (DGF) defined as the requirement for dialysis within 7 days post transplantation. |
ICOAT MEDICAL AB | 2025-04-03 |
| 197 | SGLT-2 Inhibitors on Albuminuria in Chronic Kidney Disease Patients With Lupus Nephritis and ANCA- Associated Vasculitis: Study Design and Protocol PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to investigate the effect of the glifozines on albuminuria in chronic kidney disease patients affected by lupus nephritis and ANCA associated renal vasculitis. It will also learn about the safety of glifozines. The main questions it aims to answer are: * Does glifozines lower the albuminuria of participants with chronic kidney disease secondary to lupus nephritis and ANCA associated renal vasculitis? * What medical problems do participants have when taking glifozines? Participants will: * Take glifozines every day for 6 months. * Baseline, … |
IVANA CAPUANO; | 2025-06-25 |
| 198 | SGLT2i Safety and Efficacy on Kidney Allograft Function in Non-diabetic Kidney Transplant Recipients: A Randomized, Double-blind, Placebo Controlled, National, Multicenter Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial investigates whether 18 months of daily SGLT2i (10 mg Forxiga) preserves kidney function and evaluates safety, based on eGFR changes and adverse event occurrence in non-diabetic kidney transplant recipients. The main questions it aims to answer are: * Does SGLT2i versus placebo, as an add-on to standard care, preserve kidney transplant function in non-diabetic recipients? * Is SGLT2i treatment safe for non-diabetic transplant recipients when evaluating adverse events? * Does SGLT2i versus placebo affect the occurrence of urinary tract infections, post-transplant diabetes mellitus (PTDM) and prediabetes incidence, U-ACR, … |
LOTTE B LANGE; | 2025-08-27 |
| 199 | Role of Finerenone in African American Veterans With Diabetic Kidney Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Primary Objectives: To study podocyte specific injury markers (podocyte specific proteins, PSP) nephrin, podocalyxin and Wilms’Tumor (WT-1) protein in exosomes urine from African American Veterans with albuminuric stage 2 and 3 chronic diabetic kidney disease (DKD), using Empagliflozin or Finerenone or combination therapy. Secondary Objectives: (1). Correlate changes in exosome-based PSP with standardized biomarkers of kidney injury including urine albumin/creatinine ratio (ACR) and estimated GFR. (2) with systemic inflammatory markers (focusing on vascular and endothelial function) that are already established such as interleukins (IL1, IL6, IL-12), … |
SABYASACHI SEN; | 2025-09-04 |
| 200 | Effects of Brazil Nut Supplementation on Inflammation, Oxidative Stress and Microbiota in Patients With Chronic Kidney Disease Undergoing Conservative Treatment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the effects of Brazil nut supplementation on inflammation, oxidative stress and intestinal microbiota in patients with chronic kidney disease undergoing conservative treatment. |
RENATA RODRIGUES; | 2025-04-03 |