Clinical Digest: Recent Clinical Trials on MRSA (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to MRSA. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on MRSA (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Dabigatran Vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label randomized controlled trial which will enroll patients with S. aureus bacteremia who are already taking oral anticoagulant medications (apixaban, edoxaban, or rivaroxaban) for an approved indication (stroke prevention in atrial fibrillation, prevention or treatment of venous thromboembolism). We will randomize patients to continue their existing medication or change to another medication (dabigatran) which is approved for the original indication. Dabigatran is approved in many countries for the treatment or prevention of venous thromboembolism or preventing stroke in atrial fibrillation. Unlike the other medications listed above, … |
EMILY MCDONALD; | 2026-03-20 |
| 2 | Clopidogrel Vs. Aspirin for Cardiovascular Risk Reduction in Patients With S. Aureus Bacteremia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label randomized controlled trial which will enroll patients with S. aureus bacteremia who are already taking aspirin for secondary prevention of cardiovascular events. We will randomize patients to continue their aspirin or change clopidogrel which is also approved for secondary prevention. Unlike aspirin, clopidogrel may have activity against S. aureus. We wish to determine if changing to clopidogrel will improve outcomes in S. aureus bacteremia in people who otherwise would have a reason to be taking it. This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119). If positive, … |
TODD C LEE; | 2026-03-20 |
| 3 | Early Versus Late Stopping of Antibiotics in Adults With High Risk Haematological Malignancies/Receiving Cellular Therapies and Fever (ELSA- Adult) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Pre-neutropenic fever (PNF) (fever following chemotherapy but before developing low white cells) and neutropenic fever (NF) (fever in the setting of low white cells) are very common after chemotherapy for acute leukemia, bone marrow transplantation or Chimeric Antigen Receptor T-cell (CAR T) therapy. Often, there is no bacterial cause for fever found, and in the setting of a well patient with resolved fever, some studies have shown it to be safe to cease antibiotic therapy which was commenced at the onset of fever. This reduces the overall exposure to antibiotics, … |
ABBY P DOUGLAS; | 2025-12-15 |
| 4 | Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia: A Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Ventilator-associated pneumonia is the leading nosocomial infection in the intensive care units, and is associated with prolonged mechanical ventilation and overuse of antibiotics. Initiating antibiotic therapy immediately after bacteriological sampling (immediate strategy) may expose uninfected patients to unnecessary treatment, while waiting for bacteriological confirmation (conservative strategy) may delay ventilator-associated pneumonia in infected patients. The decision to start antibiotic therapy for ventilator-associated pneumonia takes three points into account: diagnostic probability, the risks to the patient if Antibiotic Therapy is delayed, and the risk of selection of resistant bacteria. Diagnostic probability is limited, … |
NANTES UNIVERSITY HOSPITAL | 2026-03-27 |
| 5 | Doxi-Rio: Pilot Implementation of Post-exposure Prophylaxis for Sexually Transmitted Infections With Doxycycline in Rio De Janeiro, Brazil PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if doxycycline post-exposure prophylaxis (doxy-PEP) can help prevent bacterial sexually transmitted infections (STIs) among sexual and gender minorities in Rio de Janeiro, Brazil, including men who have sex with men, transgender women, and travestis who are living with HIV or using HIV pre-exposure prophylaxis (PrEP). Bacterial STIs such as syphilis, gonorrhea, and chlamydia remain common in these populations, even with existing prevention strategies. This study aims to answer the following questions: whether doxy-PEP can reduce the number of new STIs, whether it is safe and well tolerated, … |
BEATRIZ GRINSZTEJN; | 2026-03-30 |
| 6 | Predictive Model for Multidrug Resistance in Patients Admitted to The Emergency Department With Sepsis PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: Timely and accurate antibiotic administration in emergency department (ED) patients with sepsis or septic shock is vital, given mortality rates of 20% and over 40%, respectively. In high antimicrobial resistance (AMR) settings, selecting effective empirical antibiotics is challenging, requiring a balance between efficacy and minimizing multidrug-resistant organism (MDRO) emergence. A predictive model estimating AMR probability could optimize antibiotic use, improve outcomes, and reduce resistance. Although risk factors are known, no single validated model exists for predicting multidrug resistance in sepsis. Accurate prediction must integrate patient history, pathogen profiles, infection source, … |
EMILIO FELIPE HUAIER ARRIAZU; | 2025-09-11 |
| 7 | Evaluation of Biological Reaction of Direct Three Dimensional Printed Retainers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study will be to evaluate the biological reaction of direct three dimensional printed retainers. Primary objective is to evaluate bacterial growth and color stability between different thicknesses of 3d printed material used as a retainer . Secondary objective is to determine the optimal thickness for use in clear aligner fabrication based on biological performance. |
NORHAN IBRAHIM ELDSOKEE KHIDR; | 2025-08-01 |
| 8 | Yoğun Bakım Hastalarına Uygulanan Aspirasyon Bakım Paketinin Ventilatör İlişkili Pnömoni Gelişimini Önlemeye Etkisi: Yarı Deneysel Çalışma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Many pharmacological and non-pharmacological interventions are used to prevent ventilator-associated pneumonia (VAP). Nurses are directly responsible for implementing non-pharmacological interventions and therefore have an important role in preventing VAP. The most important non-pharmacological nursing interventions to prevent VAP are hand hygiene and oral care. In addition, the head of the bed should be elevated to 30°-45°, head pressure should be monitored, … |
BANU TERZI; | 2025-08-29 |
| 9 | Infectious Complications, Associated Factors, and Prognosis After Esophagectomy for Cancer: A French, Multicenter, Retrospective Study – CIFO-study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Infectious complications represent the most common postoperative adverse events following esophagectomy for cancer, such as pneumonia (15% of cases). These complications increase immediate risks, lengthen hospital stays, and worsen patient quality of life. The population includes patients admitted to intensive care after esophagectomy for cancer between January 1, 2017, and December 31, 2024. The study focuses on this population due to the increasing incidence of esophageal cancer, the increased use of surgery for these indications, and the importance of postoperative infections in these complex procedures, … |
FRANÇOIS DEPRET; | 2025-12-17 |
| 10 | Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don’t after received a short-course (≤7 days) of parenteral antibiotics. The investigators will use past medical records from four public referral hospitals in Thailand from the year 2019 to 2024. The investigators will firstly evaluate which types of patients are more likely to receive antibiotic de-escalation. Then, the investigators will estimate the impact of antibiotic de-escalation, while taking those differences into account. This way, … |
DIREK LIMMATHUROTSAKUL; | 2025-07-24 |
| 11 | Efficacy and Safety of Cold Atmospheric Plasma Combined With Endovascular Intervention in Patients With Diabetic Foot Ulcers and Lower Extremity Arterial Occlusion: A Randomized, Double-blind, Placebo-controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Critical limb ischemia is the end-stage manifestation of peripheral arterial disease (PAD), frequently presenting as ischemic rest pain, ulceration, or gangrene. Diabetes mellitus is a major risk factor for lower extremity arterial occlusion, with infrapopliteal arteries most commonly affected. Patients with diabetic foot ulcers (DFUs) have a high prevalence of neurovascular complications, poor healing, and elevated amputation and mortality rates. Large-scale cohort studies indicate that five-year survival after amputation in this population is only about 50%, underscoring the need for more effective therapies. Endovascular revascularization has become the first-line treatment for diabetic lower limb ischemia. However, despite successful revascularization, … |
LIN TAO; | 2026-01-30 |
| 12 | Antimicrobial Therapeutic Drug Monitoring During Lung Transplant Perioperative Phase PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Post-LUTX pneumonia represents a leading cause of death along the first month after LUTX. Donor-derived transmission of pathogenic species occurs up to 25% of recipients receiving a graft with a positive BAL culture, … |
GIACOMO GRASSELLI; | 2025-05-22 |
| 13 | Comparing Optimal Step-down Therapy for Children With Invasive MRSA Trimethoprim-Sulfamethoxazole Vs. Clindamycin for The Treatment of Children With Invasive MRSA Infections PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if trimethoprim-sulfamethoxazole (TMP-SMX) works to treat invasive infections due to methicillin-resistant Staphylococcus aureus (MRSA) in children. It will also learn about the safety of TMP-SMX in the treatment of children with invasive MRSA infections. The main questions it aims to answer are: -Is TMP-SMX effective at successfully treating children with invasive infections due to MRSA? What are the side effects of TMP-SMX in children taking it for invasive infections due to MRSA? Researchers will compare TMP-SMX to a clindamycin (a commonly prescribed antibiotic for the treatment of MRSA in children) to see if TMP-SMX works better, worse or the same as clindamycin for children with invasive infections due to MRSA. Participants will: Take TMP-SMX or clindamycin for the treatment of their invasive infection due to MRSA. Will follow up with the provider treating their invasive infection at the discretion of the treating provider. Keep a diary of their symptoms and any side effects of the medicine |
JAMES WOOD; | 2025-06-04 |
| 14 | Comparative Analysis of Nemonoxacin and Other Anti-methicillin Resistant Staphylococcus Aureus (Anti-MRSA) Antimicrobial Therapy in Patients With Complicated Skin and Soft Tissue Infections (cSSTI): A Retrospective Chart Review Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Increasing rates of antimicrobial resistant bacterial infections and antimicrobial therapy at home in elderly are great concern for medical care. The availability of new antibacterial agents that are effective against bacteria with resistance to other antibacterials is therefore critical to continued successful management of bacterial illnesses in the future. Nemonoxacin is a C-8 methoxy, non-fluorinated quinolone that retains potent broad-spectrum activities against Gram-positive and Gram-negative bacteria by selective inhibition of bacterial DNA topoisomerase. Nemonoxacin had greater in-vitro activity against many Gram-positive bacteria, including methicillin-susceptible S. aureus (MSSA), and ciprofloxacin-susceptible and ciprofloxacin-resistant MRSA, levofloxacin-susceptible and levofloxacin-resistant S. pneumoniae, Streptococcus pyogenes, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2025-05-06 |
| 15 | Phase 2 Study to Evaluate The Efficacy and Safety of TRL1068 for The Treatment of Chronic Prosthetic Joint Infection of The Knee or Hip Without Exchange Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making pathogens substantially more susceptible to established antibiotic treatment regimens. This Phase 2 study is designed to assess efficacy and safety of TRL1068 in combination with a DAIR (debridement, antibiotics, and implant retention) procedure for chronic prosthetic joint infections of the knee and hip, specifically, eliminating the need for the standard of care 2-stage exchange surgery, so that the original prosthesis can be retained. |
KIPLING SHARPE; | 2025-10-14 |
| 16 | A Prospective Interventional Randomized Placebo-controlled Multicenter Clinical Trial of The Efficacy, Tolerability and Safety of Phage Therapy in Combination With Standard Antibiotic Therapy in Patients With Infective Endocarditis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Infective endocarditis (IE) is an endocardial lesion caused by bacterial and/or fungal infection that most commonly affects the heart valves and/or the endocardium around implanted intracardiac devices. In general, IE is classified as a rare disease, but there has been a steady increase in incidence, … |
ZHANNA DAVIDOVNA KOBALAVA; | 2026-03-19 |
| 17 | Gut Microbiome in Orthopaedics: Effect of Probiotics on Initial Implant Migration and Joint Inflammation After Total Knee Replacement Related Papers Related Patents Related Grants Related Experts Highlight: Patients having knee replacement surgery regularly experience joint pain and compromised bone quality leading to implant loosening and periprosthetic fractures. The role of the gut microbiome, which is the collection of bacteria and other microbes within the human gastrointestinal tract, is just beginning to be recognized, including its potential effects on pain, infection, and loosening after total joint replacement. Antibiotics are regularly used in orthopaedic surgery to reduce the risk of infection, … |
BRENT LANTING; | 2025-03-18 |
| 18 | Multicenter, Randomized, Open-label, Three-arm Study on The Efficacy of Fecal Microbiota Transplantation Vs Probiotic Therapy Vs Eubiotic-gut-microbiota-boosting Diet in Order to Antibiotic-resistant Bacteria (ARB) Decolonization From The Gastrointestinal Tract of Patients Colonized With Clinically Most Significant ARBs. Looking for A Strategy to Overcome The WHO Alarm on The Antibiotic Resistance New Pandemic Threat. STOP-ARB Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this research experiment is to evaluate the effectiveness of fecal microbiota transplantation (FMT) preceded by antibiotic pre-treatment versus probiotic therapy and a standard-of-care equivalent diet designed to stimulate the growth of eubiotic gut microbiota (an active comparator enhancing the ethical value of the study and increasing the chances of spontaneous decolonization of antibiotic-resistant bacteria (ARB) in the absence of any active intervention recommended by Scientific Societies) in the decolonization of bacteria with the most clinically significant antibiotic resistance mechanisms from the gastrointestinal tract of colonized patients. This study addresses the urgent need highlighted by the World Health Organization (WHO) for new strategies to combat antibiotic resistance, aiming to prevent its progression into a global pandemic that could undermine the achievements of modern civilization. Study Hypotheses: * The decolonization rate of ARB bacteria in patients undergoing the intervention (FMT or probiotic therapy) is the same as in patients treated with standard-of-care (SoC) alone. * The decolonization rate of ARB bacteria in the intervention groups (FMT or probiotic therapy) is at least 20 percentage points higher than in patients treated with the standard approach (diet). The findings from this study may contribute to developing innovative microbiota-based therapies for the decolonization of antibiotic-resistant bacteria and help reduce the global burden of antibiotic resistance. |
MEDICAL UNIVERSITY OF WARSAW | 2025-09-03 |
| 19 | Evaluation of The Decolonization Rate and Acceptance of A Complete Nasal Decolonization Kit With Povidone Iodine for MRSA Patients Related Papers Related Patents Related Grants Related Experts Highlight: Staphylococcus aureus (S. aureus) is a leading cause of healthcare-associated infections worldwide. S. aureus colonizes several body sites, including the nose, throat, and perineum. Colonization by methicillin-resistant S. aureus (MRSA) increases the risk of infection by up to 27%, with infecting strains matching colonizing strains in up to 86% of cases. Decolonization, the goal of which is to decrease or eliminate bacterial load on the body, … |
NANTES UNIVERSITY HOSPITAL | 2025-12-23 |
| 20 | DAPTO-SNAP: Daptomycin Vs. Vancomycin for The Treatment of Methicillin Resistant S. Aureus Bacteremia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin. This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119) |
TODD C LEE; | 2026-02-24 |
| 21 | Linezolid or Vancomycin Surgical Site Infection Prophylaxis PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Anesthesia and surgical guidelines recommend the administration of a surgical antibiotic prophylaxis for patients undergoing clean surgery. The prescribed antibiotic should target the bacteria most commonly found in surgical site infections (SSIs) and the duration of administration should not exceed 24 hours to minimize the ecological risk of bacterial resistance emergence. Guidelines provide a framework for the administration of surgical antibiotic prophylaxis but their effectiveness is regularly re-evaluated by measuring the rates of SSIs and the microorganisms responsible for infectious complications after surgery. The majority of interventions required the use of first or second generation cephalosporins as surgical antibiotic prophylaxis. For patients with allergy to beta-lactams, clindamycin and vancomycin are proposed as alternatives. In the patients with methicillin-resistant S. aureus (MRSA) colonization or if those at risk of developing MRSA-associated SSI (hospital ecology, previous antibiotic treatment), only vancomycin is recommended. Vancomycin pharmacokinetics and pharmacodynamics is complex and its tissue absorption varies according to the level of tissue inflammation. This is a difficult molecule to handle, exclusively administered via intravenous route. Linezolid is a synthetic antibiotic from the oxazolidinone class. By binding to the rRNA on the 30S and 50S ribosomal subunits, it inhibits the bacterial synthesis. It is therefore a bacteriostatic antibiotic approved for the treatment of both methicillin susceptible S. aureus (MSSA) and MRSA infections. It also covers a broad spectrum of Gram positive bacteria. Its pharmacokinetics allows rapid intravenous infusion, with rapid penetration into bone and soft tissue of the surgical site during hip surgery. A large Cochrane meta-analysis reported that linezolid was superior to vancomycin in skin infections, including MRSA infections, albeit with low quality evidence. We therefore hypothesized that linezolid can be used instead of vancomycin for beta-lactam allergic patients and patients at risk of MRSA-associated SSI in general surgery. |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2026-02-05 |
| 22 | Adjunctive Fosfomycin for Treatment of Staphylococcus Aureus Bacteraemia: Protocol for A Pooled Post-hoc Analysis of Two Randomised Clinical Trials PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Staphylococcus aureus bacteraemia is a frequent and life-threatening infection, despite current standard antibiotic monotherapy. This study aims to clarify the role of fosfomycin as an adjunctive therapy for improving outcomes in patients with this serious infection. Two clinical trials suggested that adjunctive fosfomycin therapy might offer a clinical benefit in certain cases, but the results are inconclusive. We aim to analyse pooled data from these trials in order to identify subgroups of patients that might benefit most from this therapy. |
FRANCESC ESCRIHUELA-VIDAL; | 2025-01-31 |
| 23 | Preventive Antibiotic Treatment Before Insertion or Exchange of Tunneled Cuffed Catheters in Hemodialysis Patients to Prevent Early Catheter-Related Infections PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine if prophylactic antibiotic treatment can reduce the incidence of early catheter-related infections in hemodialysis patients at high risk, including those with femoral catheter placement, atrial fibrillation, or heart failure. The main questions it aims to answer are: 1. Will prophylactic antibiotic administration reduce catheter-related infections by 50% within 45 days of catheter insertion? 2. Will this intervention decrease the rate of secondary complications such as metastatic infections, cardiovascular morbidity, and mortality? Researchers will compare patients receiving prophylactic antibiotics (e.g., cefamezine and gentamicin, … |
ETTY KRUZEL-DAVILA; | 2025-02-07 |
| 24 | Effectiveness of Local Instillation of Antibiotics Compared to Systemic Antibiotics, As Adjunct to Ultrasound Guided Aspiration in The Management of Breast Abscess; A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Breast abscess, marked by localized collection of pus, frequently follows mastitis. Its prevalence soars up to 16% in the developing world. It usually presents in lactating mothers but also develops in prepubertal females as well. Conventionally it has been treated by surgical incision and drainage with antibiotic coverage, whether oral, intramuscular or intravenous. This approach requires hospital stay and general anesthesia but also have complications like scarring and disfigurement. With the financial and emotional impacts of this technique , … |
ARSLAN ANWAR; | 2025-04-01 |
| 25 | Impact of Bacterial Decolonization on Bacterial Burden Within Maternal-infant Dyads PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to measure bacterial burden, specifically Staph aureus, and how it spreads between mothers and their infants. Researchers will evaluate if the amount of bacteria on their skin remains the same after mothers use a skin antisepsis treatment prior to delivering their infants. The investigators also aim to assess participant interest in and compliance with skin antisepsis treatments. The hypothesis is that increased maternal interest will align with increased treatment compliance. |
IBUKUNOLUWA KALU; | 2025-12-08 |
| 26 | Influencing Factors of Vancomycin Trough Level in Critically Ill Children With Sepsis: A Single-Center Experience PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the work will be to measure the vancomycin trough concentration in critically ill children with sepsis in pediatric intensive care unit and its influencing factors. |
AMANY MOHAMMED EL-REBIGI; | 2024-10-20 |
| 27 | Boosting Knowledge, Attitudes, and Practices: An Experimental Study Evaluating The Effectiveness of MHealth Training on Antimicrobial Resistance for Hemodialysis Nurses PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: To evaluate the impact of an m-health training program on nurses’ knowledge, attitudes, and practices concerning antimicrobial resistance (AMR) within hemodialysis units. Design: This study utilized a controlled experimental design with cluster random assignment, adhering to the Consolidated Standards of Reporting Trials (CONSORT) guidelines. Method: A convenience sample of 64 nurses was cluster-randomized into either an experimental group (n = 32) or a control group (n = 32). The experimental group received AMR education via WhatsApp using Chabot software, while the control group received the same content through leaflets. The nurses’ knowledge, attitudes, … |
HOSSAM NAJJEM ALHAWATMEH; | 2024-07-02 |
| 28 | Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia (CERT) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: There is a variety of in vitro, in vivo (animal model), and human case series data which suggests that the addition of ertapenem to cefazolin could improve outcomes in methicillin-susceptible S. aureus bacteremia. No randomized controlled trial has been performed. This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119) |
TODD C LEE; | 2026-02-17 |
| 29 | Rapid De-escalation of Anti-MRSA Therapy Guided By S. Aureus Nares Screening in Case of Pneumonia (SNAP Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The current IDSA/ATS guidelines recommend Linezolid and Vancomycin for MRSA coverage in hospitalized patients with pneumonia, which is common clinical practice in Italy. However, a nasal PCR-assay for MRSA has a high negative predictive value and can facilitate rapid antibiotic de-escalation, thereby avoiding unnecessary anti-MRSA treatments. The indiscriminate use of these drugs has contributed to the emergence of resistant S. aureus strains and has led to significant adverse effects, without providing any survival benefits. Additionally, … |
FRANCESCO VLADIMIRO SEGALA; | 2025-05-30 |
| 30 | Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin (STOP-Vanc) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for critically ill adults with community-acquired pneumonia when compared with usual care. |
JEFFREY A FREIBERG; | 2026-02-27 |
| 31 | SHIELD (Staph Intervention for Effective Local Defense): An Open-label Randomized Controlled Trial to Assess Efficacy of A Sustained Intervention (Topical Antibiotics and Skin Antisepsis) to Decrease Staphylococcus Aureus Carriage in Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Indigenous persons experience a high burden of Staphylococcus aureus (SA) invasive disease and skin and soft tissue infections. SA carriage on the skin is factor for development of SA infections. The goal of this clinical trial is to evaluate a community-informed approach to reduce carriage of SA. Participants will be assigned to education and household supplies for prevention of SA with and without a biomedical intervention. Researchers will compare SA carriage in the two groups. |
LAURA HAMMITT; | 2026-01-12 |
| 32 | False Positive Peripheral Blood Culture in Children With Leukaemia: A Prevalence Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chemotherapy, the main treatment for childhood leukemia, has side effects on healthy cells. One of the most important of these side effects is the risk of infection due to neutropenia. In clinics, blood culture is the gold standard for the detection of possible infection risk (bacteremia, fungemia, etc.). During the diagnosis and treatment process in children with leukemia, a large number of peripheral or catheter blood cultures are performed. When the culture results are positive, it is accepted that the infection has grown. In some cases, … |
SEDA ARDAHAN SEVGİLİ; | 2024-12-01 |
| 33 | A Clinical Data-Based Model for Drug Concentration Prediction of Vancomycin in Critical Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: This study aims to use machine learning methods to establish an optimal model for predicting serum vancomycin trough concentrations in critically ill patients. Methods: This is a single-center, retrospective study. Data on serum vancomycin concentration in the Critical Care Database of Peking Union Medical College Hospital were screened and extracted to construct a prediction model using machine learning methods. The MIMIC-IV (Medical Information Mart for Intensive Care) database will be further used for external verification of the constructed model. The study has been approved by the Medical Ethics Committee of Peking Union Medical College Hospital (K24C1161). |
PEKING UNION MEDICAL COLLEGE HOSPITAL | 2024-08-31 |
| 34 | Impact of Nasal Antisepsis on Candida Auris Colonization PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, controlled, open-label trial of effect of 10% povidone iodine intranasal antisepsis on the detection of Candida auris. |
MARY K HAYDEN; | 2025-10-15 |
| 35 | Fast Antibiotic Susceptibility Testing for Gram Negative Bacteremia Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a 2-arm, multicenter, multinational, prospective, randomized, controlled clinical trial. Hospitalized subjects with blood cultures growing Gram negative bacilli (GNB) will be randomized 1:1 to have the positive blood cultures characterized using standard of care (SOC) antimicrobial susceptibility testing (AST) vs. a rapid AST method known as Reveal™ in addition to SOC AST. The purpose of the FAST trial is to evaluate whether use of a rapid phenotypic AST improves clinical outcomes compared to use of SOC AST methods in clinical settings with high resistance rates. |
RITU BANERJEE; | 2025-07-08 |
| 36 | Prevalence and Associated Mortality of Infections By Multidrug-Resistant Organisms in Adults Intensive Care Units in Argentina (PREV-AR) PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Observational 24-hr point prevalence study with longitudinal follow-up at 164 ICUs in Argentina. All adult patients (aged ≥18 years) at a participating ICU on November 24-28, 2023 with 60- day follow-up, were included. Epidemiological variables, sites of infection, isolated microorganisms, CPE colonisation, and hospital characteristics were collected. Main outcome measure was ICU mortality. |
MARIA INES STANELONI; | 2024-01-24 |
| 37 | Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis) PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when vancomycin should and should not be used * Unit-level feedback on overall vancomycin use within and across centers * Clinician education. |
KATHLEEN CHIOTOS; | 2025-09-19 |
| 38 | A Comprehensive Intervention to Improve The Level of Cleaning and Disinfection of Patients’ Units, in Order to Reduce New Acquisitions and Environmental Contamination By Multidrug Resistant Organisms: A Prospective Controlled Crossover Trial, Using VYV Led Lights and Continuous Air Filtering of Patients’ Rooms, Coupled With Establishment of A Patient’s Unit Commando Cleaning Team PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: A comprehensive intervention to improve the level of cleaning and disinfection of patients’ units, in order to reduce new acquisitions and environmental contamination by multidrug resistant organisms: a prospective controlled crossover trial, using VYV led lights and continuous air filtering of patients’ rooms, coupled with establishment of a patient’s unit commando cleaning team. |
DROR MARCHAIM; | 2025-08-03 |
| 39 | A Randomized Trial Investigating The Superiority of TDM-optimized Teicoplanin Dosing Versus Standard of Care PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Value of TDM for teicoplanin is not well defined. In this single-center low-interventional randomized trial the investigators aim to investigate the superiority of teicoplanin TDM-optimized using Model-Informed-Precision-Dosing (MIPD) of unbound concentrations versus the standard of care (dosing based on antibiotic guidelines) in target attainment. |
NYNKE JAGER; | 2026-02-18 |
| 40 | Efficacy & Health Economics of Antimicrobial-impregnated Central Venous Catheters (CVCs) Compared to Non-impregnated CVCs in Central Line-associated Bloodstream Infection Prevention in A Malaysia University Hospital Adult ICU PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Central venous catheters (CVCs) are indispensable in modern critical care. However, CVC usage is associated with complications, including central line-associated bloodstream infections (CLABSIs), which in turn, is translated to higher healthcare costs and mortality. The use of antimicrobial-impregnated CVCs is one of the strategies to reduce CLABSI. Nevertheless, its’ efficacy and beneficial effects, particularly in terms of patients’ outcome had not been homogeneously demonstrated across literature. Moreover, antimicrobial-impregnated CVCs are more expensive compared to conventional non-impregnated ones, and hence its cost-effectiveness remains doubtful. To date, … |
TAN KAI MING; | 2024-12-01 |
| 41 | Don’t Treat Ghosts: Anti-MRSA Antibiotics in Osteomyelitis Without Identified MRSA PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Osteomyelitis is described as infection and inflammation of the long bone or bone marrow, often due to an open wound, operation, or invasive trauma.1 It is invasive and involves hematogenous seeding or contiguous spread of the infectious organism |
MATTHEW CROTTY; | 2024-06-23 |
| 42 | PROMISE Trial: A PROspective Randomised Double-blind Parallel Group Placebo-controlled Multicentre Trial of Faecal MIcrobiota TranSplantation to Improve The Primary OutcomE (First Hospitalisation Due to Infection) in Patients With Cirrhosis Over 24 Months PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A feasibility trial called PROFIT has previously shown that FMT administered endoscopically into the jejunum in patients with cirrhosis is safe and feasible and have identified some potential mechanisms of action that warrant further interrogation. The aim of the PROMISE Trial is to evaluate the efficacy and mechanisms of action of encapsulated FMT (versus placebo) to reduce infection and mortality in patients with alcohol-related and metabolic dysfunction-Associated Steatotic Liver (MASLD) cirrhosis. |
GAVIN WRIGHT; | 2026-02-24 |
| 43 | Clinical Trial of A Disinfectant Intervention in Therapy Dogs to Combat Hospital-associated Pathogens and Promote Sustainability of Animal-Assisted Visitation Programs PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Hospital-based Animal-Assisted visitation programs are important complementary therapies, but concerns with infection control may challenge the sustainability of these programs. Pilot data suggest that a low-cost chlorhexidine-based intervention targeted to the dogs involved in the visitation programs holds high potential to prevent pathogen transmission during sessions. In this study, the following aims will be tested: 1) To identify program-related risk factors for acquisition of hospital-associated pathogens by pediatric patients during animal-assisted intervention (AAI) sessions during an initial run-in phase of no intervention; … |
MEGHAN F DAVIS; | 2025-09-18 |
| 44 | Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Intravenous vancomycin is considered first line therapy for serious methicillin-resistant Staphylococcus aureus (MRSA) infections including bacteremia, central nervous system infection, pneumonia, pleural space infection, bone or joint infection, prosthetic joint infection and deep abscesses. The effectiveness and toxicity of vancomycin depend on its dosing and chosen target. The most recent guidelines suggest targeting area under the curve over 24 hours over minimum inhibitory concentration (AUC/MIC) of 400 to 600. Implementation of AUC/MIC requires Bayesian software that can be variable, costly, complicated and time consuming. Ideally, AUC/MIC dosing would also require susceptibility testing by broth microdilution, … |
ANTHONY BAI; | 2026-01-23 |
| 45 | Cost-effectiveness Analysis of An Antimicrobial Stewardship Program in Regione Lombardia: Finalizzata Di Rete 2018 PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: Cost-effectiveness analysis of an Antimicrobial Stewardship program in Regione Lombardia: RF-net2018 is a prospective, experimental, multicenter, pre-post study, whose objectives are the evaluation of the efficiency of economic resources allocated to the antimicrobial stewardship program (AMS) in patients with infection and in patients with infections caused by carbapenem-resistant gram-negative (CR-GN) bacteria, identified in a network of 18 hospital facilities participating in our study. Moreover, … |
ANDREA GORI; | 2025-04-15 |
| 46 | Skin Immunity Sample Collection Involving Blisters and Biopsies PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: The way the body heals and protects itself from getting sick is called the immune response. Some people with weak immune systems get sick often or get rashes and skin infections. Researchers want to find out how the immune system and skin problems are related so they can help these people. Objective: To learn about how immune response and skin healing are related to each other. Eligibility: People ages 18-65 with hyper IgE syndrome or Job syndrome or people ages 7-65 with chronic granulomatous disease. Healthy volunteers ages 18 65 are also needed. Design: Participants will be screened with: Medical history Physical exam Possible urine tests Participants will have 1 to 3 visits within about a week. Visits will include the following: Participants will have a wells device strapped to the inside of the forearm. It will suction the skin and pull the top layer away to form 8 blisters. The skin over the blisters and the liquid inside will be collected. Participants will have up to 4 skin biopsies. A sharp tool will remove a small plug of skin from the forearm. Participants may have blood and urine tests. The skin on participants skin will be rubbed with a cotton swab. Some participants will have an overnight visit. They will have the blister device placed back on the arm. The wells will be lined up over the blister wounds. The wells will be filled with either saline or the participant s blood serum. The device will be covered and left on the arm for up to 24 hours. Doctors will periodically remove some liquid from the wells. |
IAN A MYLES; | 2024-09-30 |
| 47 | Determining The Impact of Enhanced Daily Disinfection on Environmental Contamination in Acute Care Hospital Rooms: A 3-arm Multicenter Blinded Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if enhanced daily application of disinfectant with persistent 24-hour activity decreases the environmental bioburden compared to standard practice. |
DEVERICK ANDERSON; | 2025-03-20 |
| 48 | The Use of Steri3X for Prevention of Post-operative Wound Infections in Cesarean Sections PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Postpartum infection if a major cause of maternal morbidity and mortality and surgical site infections are some of the common complications following cesarean section. This study aims to determine the effect of Steri3X on the incidence of cesarean section SSI at Regional One Hospital. |
RAMONA PHINEHAS; | 2024-02-07 |
| 49 | Effect of Using of Ozone-based Eye Drops As Adjuvant Therapy in The Management of Microbial Keratitis in Comparison to The Conventional Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To compare the therapeutic effect of ozone-based eye drops as an adjuvant therapy to that of the conventional topical antimicrobial agents in patients with microbial keratitis . The therapeutic response will be evaluated with clinical examination follow up . |
ABEER ABDEL-FATTAH MOHAMMED ALI; | 2023-05-01 |
| 50 | Prospective Evaluation of Xerava™ (Eravacycline) Prophylaxis in Hematological Malignancy Patients With Prolonged Neutropenia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Antibacterial prophylaxis is recommended in patients at high risk of infection, specifically patients undergoing acute leukemia induction therapy or hematopoietic stem cell transplant (HSCT) who are expected to have profound neutropenia (ANC<100 neutrophils/milliliter) for more than seven days. Xerava™ (eravacycline) has a broad spectrum of activity including many multi-drug resistant strains of bacteria. It is not an agent used for treatment of febrile neutropenia, making eravacycline a very attractive alternative to consider in this prophylactic setting. Eravacycline has activity against MRSA, VRE, and Clostridioides difficile, ... |
AARON CUMPSTON; | 2024-12-01 |
| 51 | A Prospective Single-blind Placebo-controlled Trial to Establish The Efficacy and Tolerability of 10% Povidone-Iodine for Nasal S. Aureus and Methicillin Resistant Staphylococcus Aureus (MRSA) Decolonization Among Patients Undergoing Same-day Surgery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy and tolerability of 10% povidone-iodine in eliminating nasal carriage of Staphylococcus aureus and MRSA. To determine whether a more convenient, single-dose, pre-operative 10% povidone-iodine (PI) application is effective in reducing nasal carriage of S. aureus and MRSA. We expect a statistically significant decrease in S. aureus/MRSA colonization in nasal cultures taken perioperatively after intervention in patients who received pretreatment with PI as compared to patients who received normal saline (NS). |
DENNIS GRECH; | 2023-12-31 |
| 52 | Evaluation of Microbial and Endocrinological Parameters in Dialysis Patients With Sepsis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective study aims to evaluate the diagnostic value and reliability of blood cultures obtained from different sources-central venous catheter (CVC), dialysis machine, and peripheral vein-in hemodialysis patients with suspected catheter-related bloodstream infections (CRBSIs). By comparing the timing and rates of bacterial growth from each site, the study seeks to identify the most accurate and timely method for diagnosing bloodstream infections in this patient population. In addition, the study will assess the dynamics of parathyroid hormone (PTH) levels during acute infections. Specifically, … |
ETTY KRUZEL-DAVILA; | 2025-05-14 |
| 53 | MRSA Decolonization in Complicated Carriage – Cluster Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Multicenter open-label cluster randomized controlled trial determining the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRSA carriership. |
MEREL LAMBREGTS; | 2025-03-06 |
| 54 | Efficacy of Infection Control Program on Reducing Tracheostomy Tube Colonization With Biofilm Producing Antimicrobial Resistant Bacteria PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Healthcare-associated infections are infections that patients acquire during the course of receiving treatment for other conditions within a healthcare setting and are not present at the time of admission. Medical instrumentation increases the risk of development of HAIs. Such devices include, venous and urinary catheters, and ventilators. Most ventilator-dependent patients undergo respiratory stabilization with an endotracheal tube in a critical care setting. Later on, translaryngeal tubes are converted to a tracheostomy to provide long-term airway access for ventilatory support. Tracheostomy is a commonly performed airway surgery for critically ill patients. It has variable complications, … |
HANAA AREF; | 2023-12-01 |
| 55 | Evaluation of The Tolerability, Safety of Use, and Efficacy of Cosmetic Products for The Oral Care. In Use Test Under Dentist Control PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this open-label, randomized controlled clinical trial, is to provide preliminary clinical data (efficacy on plaque and gingival sensitivity, and safety and tolerability of two types of toothpaste, a mouthwash, and a specifically custom-designed toothbrush used for 28 days), … |
DARIO CATTANEO; | 2025-05-22 |
| 56 | Three Weeks Versus Six Weeks Antibiotic Therapy for Nonsurgically Treated Diabetic Foot Osteomyelitis : A Multicenter, Randomized, Open-label and Controlled Study Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this clinical study is to compare the efficacy and tolerance of 3 versus 6 weeks of antibiotherapy in patients with diabetic foot osteomyelitis treated medically. |
ERIC M SENNEVILLE; | 2026-01-14 |
| 57 | A Multicenter, Double-blinded, Randomized, Parallel Design, Phase IIa Clinical Trial to Evaluate The Efficacy, Safety and PK of LCB01-0371 With Vancomycin Versus Vancomycin Monotherapy in Patients With MRSA Bacteremia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objectives of this study is to exploratory whether Vancomycin + Delpazolid is more effective to the standard of treatment (Vancomycin)/ for hospitalized adults with MRSA bacteraemia. |
HONGBIN KIM; | 2025-05-06 |
| 58 | Effect of Expanding Barrier Precautions for Reducing Clostridium Difficile Acquisition in VA PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Clostridium difficile (C. difficile) is a major pathogen causing serious healthcare-associated diarrheal illness in patients. Prevention of healthcare facility-onset C. difficile infection (CDI) is essential. Many CDI cases are caused by the transmission of the pathogen from patients who carry the bacteria, but do not have symptoms. However, there are limited data on how to prevent the transmission of C. difficile from patients who do not have symptoms. Universal gloving practices – the use of gloves by all healthcare workers for all patient contacts – may reduce CDI cases. In this study, … |
NASIA SAFDAR; | 2025-07-11 |
| 59 | The Impact of Hospital Care for COVID-19 on The Prevalence of Multidrug-resistant Microorganisms Among Patients Compared to Non-COVID-19 Hospital Care in Limited-resource Hospitals in Indonesia PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The effect of the COVID-19 pandemic on the emergence and spread of antibiotic-resistant bacteria is largely unknown, especially in low-resource settings. We aim to investigate the prevalence and relatedness of multidrug-resistant bacteria among patients in both COVID-19 and non-COVID-19 wards in two hospitals in Indonesia. Bacterial isolates will be collected from clinical sample and by screening of patients at discharge followed by 30 days after discharge. Aspects of hospital care that may be different in COVID-19 wards versus non-COVID-19 wards and that are considered important determinants for antimicrobial resistance (AMR) will be measured: hand hygiene compliance, … |
JULIËTTE SEVERIN; | 2023-03-07 |
| 60 | A Phase 1, Open-Label, Randomized, Crossover Study to Assess The Safety and Pharmacokinetics Following Single Doses of Oral and Intravenous Xenleta (Lefamulin) in Adult Patients With Cystic Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is intended to assess the PK and safety of a single dose of IV and oral formulations of lefamulin in adults with CF. |
NABRIVA THERAPEUTICS AG | 2023-01-13 |
| 61 | Improving Carbapenemase-Producing Organism (CPO) and Vancomycin-Resistant Enterococcus (VRE) Management With BD Solutions PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Emergence of vancomycin-resistant enterococci (VRE) and carbapenemase-producing enterobacteria (CPE) is nowadays a major public health concern worldwide. VRE and CPE are referred to as Emerging eXtensively Drug Resistant bacteria (eXDR). A better, faster and more accurate identification of VRE and CPE would allow faster appropriate therapy for patients and/or infection control strategies. Faster appropriate therapy could improve mortality rates, length of stay, and other patient outcomes as well as hospital costs. BD offers a variety of products, services and solutions designed to increase efficiency, streamline processes, … |
SANDRINE BOISSET; | 2024-02-01 |
| 62 | Bacterial Eradication of The Nasal Epithelium From Infectious Toxins With PDT (BENEFIT-PDT) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 2 single-center, open-label, single-arm, study of a microbiological endpoint using antimicrobial photodynamic therapy (aPDT) for nasal disinfection in all patients (universal) presenting for surgery at an acute care hospital for a wide range of surgical procedures. |
STEPHEN A. THACKER; | 2022-08-06 |
| 63 | Nasopharyngeal Bacterial Carriage and Antibiotic Resistance in Children With Sickle Cell Disease in Ile-De-France PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to to determine the rate of nasopharyngeal carriage of Streptococcus pneumoniae (Sp) in children with sickle cell disease over 6 months and under 15 years of age over a 9-month period in Ile-De-France. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-02-01 |
| 64 | Prevalence of Multidrug Resistant Micro-organism Carriage in Patients Undergoing An Endoscopic Retrograde Cholangiopancreatography in Four Different Countries PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The duodenoscopes currently used for Endoscopic Retrograde Cholangio – and Pancreaticography (ERCP) examinations are reusable and are therefore washed and disinfected after each use. Despite this, these endoscopes sometimes remain contaminated with bacteria. Several reports of outbreaks linked to contaminated duodenoscopes have been published worldwide. Recently, the Food and Drug Administration (FDA) advised manufacturers and health care professionals to transition away from fixed endcap duodenoscopes and instead focus more on the use of duodenoscopes with disposable components or fully disposable duodenoscopes. Single-use endoscopes have been developed, but they are not yet widely used, … |
MARCO J. BRUNO; | 2025-08-08 |
| 65 | Microbiological Assessment of Air and Surfaces of Operation Rooms in Assuit University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. To determine the bacteriological load on air and surfaces within the ORs. 2. To isolate and identify pathogenic strains of bacteria on equipments and contact surfaces. 3. To compare between adenosine triphosphate bioluminescence assay and the ordinary cultures in order to verify whether the methods of hygienization and disinfection implemented were in fact effective. |
ESRAA HUSSIEN MAHRAN SHEHATA; | 2024-01-01 |
| 66 | A Randomized Double-blind Controlled Clinical Trial Comparing A Synergistic Antimicrobial Cleanser and Gel to Normal Saline and An Amorphous Gel in Reducing Bioburden and Promoting Healing in Chronic Lower Extremity Ulcers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a randomized double-blind controlled clinical trial designed to compare healing rates between normal saline wash in combination with an amorphous gel (NSS-HG) versus the grouping of a synergistic antimicrobial cleanser (AMC) and antimicrobial gel (AMG) in chronic lower extremity ulcers. After consenting, the ulcers of eligible subjects are measured, … |
SERENAGROUP | 2023-03-01 |
| 67 | Comparative Efficacy of Intravenous Cefuroxime and Ceftriaxone in Preventing Surgical Site Infection After Neurosurgical Procedures PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay. The appropriate and timely use of prophylactic antibiotics is found to reduce the prevalence of SSIs. At present, several regimen of antimicrobial agents are used in neurosurgical procedures since the choice of appropriate antibiotic agent is not fully established. Cephalosporins are among the frequently used antibiotics for prophylaxis in neurosurgical procedures, with studies comparing first and second generation Cephalosporins to third generation in neurosurgical prophylaxis, … |
PROMISE TAMUNOIPIRIALA JAJA; | 2022-07-01 |
| 68 | Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomised controlled trial will determine the non-inferiority of stopping empiric antibiotics prior to absolute neutrophil count (ANC) recovery (Early Stopping) versus stopping antibiotics upon ANC recovery (Standard of Care/ Late Stopping) , in children with cancer and high-risk febrile neutropenia (FN). |
GABRIELLE HAEUSLER; | 2026-03-20 |
| 69 | Effect of Antibiotic Choice On ReNal Outcomes (ACORN) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Sepsis is one of the most common causes of acute illness and death in the United States. Early, empiric broad-spectrum antibiotics are a mainstay of sepsis treatment. Two classes of antibiotics with activity against Pseudomonas, anti-pseudomonal cephalosporins and anti-pseudomonal penicillins, are commonly used for acutely ill adults with sepsis in current practice. Recent observational studies, however, have raised concern that anti-pseudomonal penicillins may cause renal toxicity. Anti-pseudomonal cephalosporins, by comparison, may be associated with a risk of neurotoxicity. Rigorous, … |
EDDIE QIAN; | 2022-10-21 |
| 70 | NAsal MEthicillin-resistant Staphylococcus (NAMES): A Prospective Study to Assess The Impact of Antibiotic Therapy on Nasal Colonization with Methicillin-resistant Staphylococcus Aureus (MRSA) in Hospitalized Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Antimicrobial resistance (AMR) is recognized as one of the major threats to global health \[1\], causing up to 25.000 deaths in the European Union every year, longer hospitalizations and increased healthcare costs. It is well known that antimicrobial use is the main driving force towards AMR and up to 50% of antimicrobial prescriptions are either inappropriate or unnecessary \[2\]. It is then important to understand how to optimize antimicrobial usage not only in adults but also in infants, … |
ALESSANDRA RICCIARDI; | 2025-03-12 |
| 71 | Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to find out how Avenova (0.01 % hypochlorous acid) works compared to Betadine (Povidone iodide) for reducing bacteria and patient discomfort in the eyes. |
JORGE FORTUN; | 2025-07-10 |
| 72 | What Happened? Antimicrobial Resistance During The SARS-CoV-2 (COVID-19) Pandemic PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Assess the incidence and rates of resistant pathogens prior to and during the COVID-19 pandemic. |
MATHEW CROTTY; | 2025-07-28 |
| 73 | Pharmacokinetics of Omadacycline in Patients With Cystic Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to characterize the pharmacokinetics of intravenous and oral omadacycline in patients with cystic fibrosis. |
PAUL BERINGER; | 2023-12-31 |
| 74 | The Pattern of Antibiotic Prescription for Children Among A Group of Pediatric Dentists PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to determine the pattern of antibiotic prescription for children among a group of pediatric dentists |
AHMED MOSTAFA ABDO ELGENDY; | 2022-06-01 |
| 75 | A Prospective Cohort Study to Investigate The Transmission and Burden of PVL-MRSA in Households in Sri Lanka PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will determine the frequency of Staphylococcus aureus carriage in household contacts of individuals with clinical infection due to this pathogen. It will also assess the frequency of transmission events over the following three months. Finally it will aim to identify predisposing characteristics both on a demographic/social level as well virulence characteristics of the identified strains. |
THOMAS DARTON; | 2021-09-01 |
| 76 | Vancomycin Monitoring: Is AUC Monitoring Appropriate for More Than Just Serious MRSA Infections? PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Vancomycin, a glycopeptide antibiotic, is commonly prescribed as initial therapy for hospitalized patients due to its broad gram-positive coverage. Vancomycin is used for the treatment and prevention of a variety of bacterial infections ranging from streptococcal to methicillin-resistant Staphylococcus aureus (MRSA) infections.1 Notable adverse effects of intravenous vancomycin include nephrotoxicity, ototoxicity and hypersensitivity reactions. Given its pharmacokinetic profile, therapeutic drug monitoring is essential in determining the therapeutic efficacy of vancomycin as well as for avoiding nephrotoxicity. |
AKINS RONDA; | 2023-04-08 |
| 77 | Aged European Population QUality of Life in Infectious Diseases PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The increasing number of persons \>65 years of age form a special population at risk for nosocomial and other health care-associated infections. The vulnerability of this age group is related to impaired host defenses such as diminished cell-mediated immunity. Lifestyle considerations, e.g., travel and living arrangements, and residence in nursing homes, … |
UNIVERSITY HOSPITAL GRENOBLE | 2025-08-13 |
| 78 | Pharmacokinetics of New Licensed Antibiotics in Critically Ill Patients Receiving Continuous Venovenous Haemofiltration: An International Collaborative Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The mortality in patients with sepsis and severe acute kidney injury requiring continuous renal replacement therapy (CRRT) remains high. Antibiotic therapy is a key treatment of these patients and in recent years new antibiotics have been licensed. However, data is lacking to determine the optimal dosing regimens of these antibiotics for high (Australia and other countries) and low intensity (Japan) of CRRT. Aim To establish the appropriate dosing regimens of newly available antibiotics during CRRT can applied globally. |
OSAKA UNIVERSITY | 2023-04-01 |
| 79 | A Study on Plasma and Pulmonary Pharmacokinetics of High-dose Ceftobiprole Given By Continuous Infusion in Mechanically-ventilated Adult Patients With Severe Community-acquired Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main aim of the study is to describe plasma pharmacokinetics (PK) and pulmonary diffusion of high-dose ceftobiprole (500 mg loading dose followed by 2.5 g under continuous infusion for 24h) for mechanically-ventilated adult patients with severe community-acquired pneumonia, using population PK modelling. The secondary aims are : A- To determine whether the pharmacokinetic / pharmacodynamic (PK/PD) targets can be achieved in the plasma and epithelial lining fluid with the recommended doses of ceftobiprole. B- To define the optimal dose regimen for ceftobiprole in this population. C- … |
CENTRE HOSPITALIER UNIVERSITAIRE DE NĪMES | 2025-12-05 |
| 80 | A Phase I/IIa, Randomised, Double-blind, Placebo-controlled Study to Evaluate The Safety and Exploratory Efficacy of 3% LTX-109 Compared to Placebo for Nasal Decolonisation of Staphylococcus Aureus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A Phase I/IIa, double-blind, placebo-controlled, randomised study designed to evaluate the safety, tolerability, exploratory efficacy and exposure of LTX-109 administered topically to the anterior nares in subjects with persistent carriage of S. aureus (methicillin-susceptible S. aureus [MSSA] and/or methicillin-resistant S. aureus [MRSA]). |
JOHAN NILSSON; | 2021-06-01 |
| 81 | A Phase 1, Blinded, Single Ascending Dose Study to Evaluate Safety, Pharmacokinetics, and Activity of TRL1068 in Subjects With Prosthetic Joint Infection of The Knee or Hip, Undergoing Primary Two Stage Exchange Arthroplasty PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making these pathogens substantially more susceptible to established antibiotic treatment regimens. This initial study is designed to assess overall safety and pharmacokinetics (PK) of TRL1068. The overall goal of the development program is to demonstrate that TRL1068 can facilitate effectiveness of a single stage joint replacement or preservation of the original infected prosthetic joint in a substantial proportion of patients with PJI. |
NICHOLAS BERNTHAL; | 2023-09-01 |
| 82 | Expanded Access Study of A Single Dose of Exebacase in Addition to Antistaphylococcal Antibiotics for The Treatment of Persistent Methicillin-Resistant Staphylococcus Aureus (MRSA) Bloodstream Infections (Including Right Sided Endocarditis) in Patients Who Are Hospitalized With Coronavirus Disease 2019 (COVID-19) Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label, expanded access study of exebacase used in addition to antistaphylococcal antibiotics in adult patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI), including right-sided endocarditis (R-IE), who are hospitalized with coronavirus disease 2019 (COVID-19). Patients with left-sided endocarditis (L-IE) are excluded. Patients will receive a single dose of exebacase. Patients will continue to receive antistaphylococcal antibiotics as prescribed by the treating physician. Exebacase Phase 3 study sites (Study CF-301-105) may participate in this Expanded Access study (Study CF-301-107). Exebacase, a direct lytic agent, … |
CONTRAFECT | 2022-08-25 |
| 83 | CleanHands Sensor Based System to Improve Hand Hygiene and Reduce Infection Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if use of the CleanHands system can improve hand hygiene/personal protective equipment (PPE) compliance and reduce infections in the hospital ICUs through reminders to wash hands and use PPE as appropriate. |
JIAPENG HUANG; | 2022-08-29 |
| 84 | MSSA and MRSA Screening in Patients Undergoing Elective TJA: The Benefits of Next-generation Sequencing PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aims of this study were to evaluate the diagnostic performance of molecular and culture techniques in S. aureus screening using paired nasal and groin swabs, to determine, if any, discrepancy between the diagnostic techniques and to model the potential effect of different diagnostic techniques on S. aureus detection in orthopaedic patients |
ROTHMAN INSTITUTE ORTHOPAEDICS | 2021-08-30 |
| 85 | Non-interventional Observational Study of Daptomycin in The Treatment of Gram-positive Bacterial Infections PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to collect and analyze clinical data of daptomycin to explore the efficacy and safety of daptomycin in the treatment of Gram-positive bacterial infections. And optimize the dosing regimen based on these data. |
XIAOJUN X MA; | 2022-08-01 |
| 86 | Skin Closures at Cesarean Delivery, Glue Vs Subcuticular Sutures: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The optimal choice of skin closure at cesarean delivery has not yet been determined. This study will compare wound complications and scar healing following cesarean delivery between 2 methods of skin closure: glue (Dermabond®; Ethicon, Somerville, NJ) and monofilament (Monocryl®; Ethicon) epidermal sutures. |
AHMED MOHAMMED ELMARAGHY; | 2021-03-01 |
| 87 | Dalbavancin in Real Clinical Practice in Spain: A Two-year Retrospective Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to describe the real clinical use of Dalbavancin in Spain between January 2018 and December 2019. |
BENITO ALMIRANTE; | 2021-02-21 |
| 88 | Interplay Between Gut Microbiota and Adaptive Immunity in Amyotrophic Lateral Sclerosis: A Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Given the role of adaptive immunity in ALS, the pathogenicity of some clostridial strains on motorneurons, the putative role of cyanobacteria in ALS development, and the increasing interest for microbiota in neurodegenerative disorders, the modification of intestinal microbiota might affect ALS at its core. This interventional study aims at evaluating the biological and disease-modifying effects of Fecal Microbiota Transplant (FMT) in patients affected by Amyotrophic Lateral Sclerosis. As a primary aim of the study, the investigators postulate ALS patients treated with FMT compared to the control arm will display increased Tregs number, … |
JESSICA MANDRIOLI; | 2023-08-01 |
| 89 | Retrospective Effectiveness Study of Dalbavancin and Other Standard of Care of The Same Class (i.v. Lipo and Glyco-peptides) in Patients With ABSSSI PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to collect the data on the effectiveness of dalbavancin in terms of save of hospitalization days on patients treated between June 2017 and June 2019 in two countries (Italy and Greece) vs the other Standards of care of the same class (SoC; i.v. lipo and glycopeptides) in a real-life context. Time to discharge from the start of therapy for ABSSSI in the hospital context will be assessed and all relevant data available on patient management, clinical, … |
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S P A | 2021-05-19 |
| 90 | Antibiotic Prophylaxis in High-Risk Arthroplasty Patients PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population. |
NICHOLAS A. BEDARD; | 2025-07-03 |
| 91 | Bactericidal Effect of Silver Nanoparticles on Methecillin and Vancomycin Resistant Staphylococcus. Aureus (MRSA) Isolated From Critically Ill Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Recently, silver nanoparticles (AgNPs) have been widely used in various applications as antimicrobial agents, anticancer, diagnostics, biomarkers, cell labels, and drug delivery systems for the treatment of various diseases. The present study investigated the bactericidal effect of AgNPs against Methecillin Resistant Staph. aureus (MRSA) and Vancomycin resistant Staph aureus (VRSA) |
RASHA HAMED; | 2020-10-13 |
| 92 | A Randomized Placebo-controlled Double-blinded Trial of The Treatment of MRSA Throat Carriage With Either Standard Decolonization Therapy or Standard Decolonization Therapy Combined With Oral Clindamycin PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the optimal way to treat MRSA throat carriers. |
MONA KATRINE ALBERTHE HOLM; | 2025-09-24 |
| 93 | Topical Gentamicin and Vancomycin for Surgical Site Infection Prophylaxis in Patients Undergoing High-Risk Vascular Surgery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Many patients who undergo vascular surgery to improve the blood flow to their legs are at risk of developing an infection in the surgical site and are then at risk of serious complications such as hospital readmission, failure of the surgical procedure and lower limb amputation. Surgical site infections may be reduced in high-risk patients by applying two commonly used antibiotics (gentamicin and vancomycin) into the surgical incision at the end of the surgical procedure. This will be compared to the standard of care treatment at London Health Sciences Center. |
LUC DUBOIS; | 2021-07-01 |
| 94 | Cluster Randomized Trial With Cross-over of Targeted Gown and Glove Intervention to Prevent Staphylococcus Aureus and Carbapenem-resistant Gram-negative Bacteria Acquisition in Community-based Nursing Homes Related Papers Related Patents Related Grants Related Experts Highlight: This project will assess the feasibility of a cluster-randomized trial with crossover of our intervention, targeted gown and glove use, among high-risk residents of community nursing homes to prevent Staphylococcus aureus and carbapenem gram negative bacteria acquisition and infection. |
MARY-CLAIRE ROGHMANN; | 2020-03-10 |
| 95 | Probiotic Bacillus for Decolonization of Methicillin-resistant Staphylococcus Aureus (MRSA) in Patients Undergoing Total Joint Arthroplasty: A Randomized, Prospective, Placebo-Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This pilot study is designed to determine if ingestion of Bacillus probiotics can cause alteration in levels of S. aureus colonization in the nose and intestine in preoperative orthopedic patients undergoing elective primary TJA. |
ROTHMAN INSTITUTE ORTHOPAEDICS | 2021-01-22 |
| 96 | Povidone-Iodine Rinses As An Adjuvant Therapy Post-Operatively: A Double-Blind Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Povidone Iodine solution is a nasal antiseptic. Its application has been shown to be clinically safe, tolerable and effective against bacteria and fungi associated with chronic rhinosinusitis. The purpose of this study is determining the effectiveness of PVP-I in comparison to a placebo for post-operative refractory CRS patients in a randomized controlled trial. |
AMIN JAVER; | 2021-02-10 |
| 97 | Evaluation of The Tolerance of Anti-MRSA Betalactamines (Ceftaroline / Ceftobiprole) in The Management of BJI / PJI: A Retrospective Study in A Reference Center PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Staphyloccous aureus and coagulase negative staphylocci are responsible of a large marjority of PJI. Regarding the high rate of methicillin resistance, current guidelines recommend the use of a glycopeptide, and most frequently vancomycin, as the anti-gram positive agent in empirical therapy, while awaiting the microbiological results. Vancomycin is not considered as a safe antibiotic, and daptomycin is frequently an alternative option. Ceftaroline and ceftobiprole are the only betalactam active on methicillin-resistant staphylococci. As some data report a synergistic activity with daptomycin, they could be an option in pandrug-resistant staphylococci BJI, but their use if off label in this indication. |
HOSPICES CIVILS DE LYON | 2020-05-05 |
| 98 | A Population PK Study Into Teicoplanin in Intensive Care and Haematology Patients – A Strategy Towards Model Informed Precision Dosing PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Characterize teicoplanin PK in critically ill patients with a specific focus on alterations of exposure due to variability in renal function. In a prospective, observational, open-label study the investigators aim to define PK of free drug concentrations of teicoplanine in ICU and heamatology patients and define a PK model for Bayesian dose individualization. |
RADBOUD UNIVERSITY MEDICAL CENTER | 2022-12-01 |
| 99 | Relation Between Adherence to Hand Hygiene Practices By Healthcare Providers Working in Intensive Care Unit and Microbial Contamination on Feeding Tubes and Other Components of Feeding Systems PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Enteral feeding tube (EFT) and component of feeding systems can serve as a reservoir of microorganisms, and the main reason is inappropriate hand hygiene practices. The aim of the project is to determine colonization of microorganisms on the EFT and other components and assess the relation between colonization and adherence to hand hygiene practices by healthcare workers in the intensive care unit. This prospective, … |
NURTEN OZEN; | 2021-02-01 |
| 100 | Tracing MRSA in Households With Patients Infected With CA-MRSA By WGS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: From the 1980s to the late 1990s, highly toxic methicillin-resistant Staphylococcus aureus (MRSA) strains (called community-associated [CA] MRSA) appeared in the community. Although the prevalence of HA-MRSA (health-related MRSA) infection remained stable between 1998 and 2008, the CA-MRSA (community-related MRSA) infection rate increased. By far, the most common manifestations of CA-MRSA related diseases are skin and soft tissue infections. Skin and soft tissue infections (SSTIs) account for at least 90% of CA-MRSA infections. CA-MRSA strains also cause bone and joint infections, such as osteomyelitis and respiratory infections, such as pneumonia, sepsis, … |
JIAN-CANG ZHOU M.D.; | 2020-03-17 |
| 101 | Investigator Driven Randomized Controlled Trial of Cefiderocol Versus Standard Therapy for Healthcare Associated and Hospital Acquired Gram-negative Blood Stream Infection: Study Protocol (the GAME CHANGER Trial) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of care. |
DAVID PATERSON; | 2023-03-31 |
| 102 | An Open-label, Dose-escalation Study to Evaluate The Pharmacokinetics of Inhaled Teicoplanin in Cystic Fibrosis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cystic Fibrosis (CF) is the most common autosomal recessive lethal disorders affecting 1:2.500 newborns among Caucasians. CF patients are peculiarly susceptible to infection and colonization of the respiratory tract with pathogens. In particular, Methicillin-resistant Staphylococcus aureus (MRSA) has become the third most prevalent bacterium in CF in the U.S. and has been increasing in other countries. Apart from the difficulty of treating the infection because of its antimicrobial resistances, MRSA is transmissible between individuals with and without CF. Chronic MRSA infection is associated with worse outcomes, … |
GIULIA PAIOLA; | 2020-09-30 |
| 103 | Double-blind Clinical Trials of Probiotic Products in Oral Health PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In order to evaluate the effects of supplementary probiotics and their metabolites on oral environment and oral microbiota, Taiwan FDA No. 88037803 will be used to evaluate the effects of oral probiotic candidate strains from previous research results and develop oral probiotic products. |
HSIEH-HSUN HO; | 2019-12-06 |
| 104 | Efficacy of An Antimicrobial Stewardship Intervention for Early Adaptation of Empirical Antibiotic Therapy in High-risk Neutropenic Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Febrile neutropenia (FN) is a frequent and serious complication in patients with hematological malignancies undergoing intensive chemotherapy. The growth of antibiotic resistance is a major threat in high-risk neutropenic patients given that delay in introduction of appropriate empirical antibiotic therapy (EAT) in this population is associated with increased morbidity and mortality. In 2013, the 4th European Conference on Infections in Leukaemia (ECIL-4) group published new guidelines, promoting early adaptation of EAT in stable afebrile patients, regardless of neutrophil count and expected duration of neutropenia. Despite these evidence-based guidelines, discontinuation and de-escalation strategies are not widely implemented in hematology departments. However, … |
CENTRE HOSPITALIER UNIVERSITAIRE DE NICE | 2022-05-31 |
| 105 | Measuring The Impact of An Enhanced Strategy for Daily Disinfection in Acute Care Hospital Rooms PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To determine the effectiveness of an enhanced strategy for daily disinfection in acute care hospital rooms comparing the addition of sani24 to routine daily cleaning versus the control of routine daily cleaning. |
NICK TURNER; | 2022-03-17 |
| 106 | Dissemination and Resistance Mechanisms of Carbapenem-resistant Gram-negative Bacilli and Methicillin-resistant Staphylococcus Aureus in Intensive Care Units in China PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Carbapenem-resistant Gram-negative bacilli [Carbapenem-resistant Acinetobacter baumannii (CRAB), Carbapenem-resistant Klebsiella pneumoniae (CRKP), and Carbapenem-resistant Pseudomonas aeruginosa (CRPsA) ] and methicillin-resistant Staphylococcus aureus (MRSA) is prevalent around the world, and the isolation rate and resistance rate has increasing in China. The limited treatment and high mortality rate of these pathogens infections has resulted in difficulty in clinical anti-infection treatment, so it is urgent to illustrate the transmission mechanism, resistance mechanism and horizontal transfer mechanism of resistance genes in intensive care unit (ICU). Furthermore, this study was aimed to investigate the epidemiology and risk factors, … |
JIAN-CANG ZHOU M.D.; | 2020-12-01 |
| 107 | Remote Physician Care for Home Hospital Patients: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits. |
DAVID LEVINE; | 2020-04-27 |
| 108 | Effect of PCR-CRISPR/Cas12a on The Early Anti-infective Schemes in Patients With Open Air Pneumonia PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multicenter randomized controlled trial. The purpose of this study is to assess the efficacy of the combination of PCR and CRISPR/Cas12a in alveolar lavage fluid for early targeted anti-infective therapy for patients with severe pneumonia. Hosted by the Department of Critical Care Medicine, Affiliated Drum Tower Hospital of Nanjing University Medical College, 5 adult ICU units participate in 3 hospitals. All patients are randomly assigned to the experimental group and the control group. For experimental group, the combined detection of PCR and CRISPR/Cas12a in the alveolar lavage fluid was carried out in the early stage, … |
CHINESE MEDICAL ASSOCIATION | 2020-08-30 |
| 109 | Surveillance of Community-Associated MRSA and Treatment Outcomes of Skin and Soft Tissue Infections in The Ambulatory Setting PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to obtain information from patients diagnosed with a skin and soft tissue infection (also known as an abscess or ‘boil’ or ‘rising’) and determine whether or not MRSA is present in the child’s different surface skin areas or nose. We also plan to compare how these infections look in the lab, by identifying in detail parts of the germ that caused the infection or is found on the skin/nose areas |
CHILDREN’S HEALTHCARE OF ATLANTA | 2020-07-08 |
| 110 | Peri-operative Application of EYEPROTX General Anesthesia Protective Goggles As An Effective Modality to Reduce The Incidence of Corneal Injury Post-Intubation Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized controlled trial that seeks to examine the effectiveness of Eyeprotx™ protective goggles in comparison to traditional methods against ocular injury that can occur perioperatively under general anesthesia. |
LEO KLEYMAN; | 2019-12-01 |
| 111 | Randomized Trial of Fast Bacterial Identification and Phenotypic Antimicrobial Susceptibility Testing in Patients With Positive Blood Cultures Using The Accelerate PhenoTest™ BC Kit, Performed on The Accelerate Pheno™ System As Compared With The Verigene® BC-GP/GN PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed as a prospective, randomized, open-label trial evaluating antimicrobial utilization, clinical outcomes, and healthcare costs among patients with positive blood cultures. Patients will be randomized to one of the following FDA-cleared devices that will be used to assess the workflow impact of fast identification (ID) and antimicrobial susceptibility testing (AST) in the microbiology lab and in the quality of care in patients: 1) Standard culture and AST of positive blood culture bottles plus the Verigene® Blood Culture Gram-positive/Gram-negative kit (BC-GP/GN); … |
ACCELERATE DIAGNOSTICS | 2023-06-01 |
| 112 | Does The Use of Topical Otic Drops at The Time of Tympanostomy Tube Placement Improve Outcomes When No Middle Ear Effusion Is Present at The Time of Surgery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To determine whether the use of topical otic drops intra-operative and post-operative during tympanostomy tube placement reduces the rate of tympanostomy tube occlusion and post-operative otorrhea (ear drainage) during the initial 4-week post-operative period in subjects with no middle ear effusion (fluid behind the ear drum) present at the time of surgery. A within subject controlled study design will be utilized to study this effect. Subjects with absent middle ear effusion who are receiving tympanostomy tube placement will receive a standard protocol of Floxin topical drops during surgery and after surgery in one ear. Selection of ear (right ear or left ear) will be randomized. The primary measured outcome will be the rate of tympanostomy tube occlusion within first 4 weeks postoperatively. The secondary measured outcome is the rate of tympanostomy tube otorrhea (drainage) within first 4 weeks postoperatively. |
KENNETH WHITTEMORE; | 2022-09-01 |
| 113 | Incidence and Outcome of Sepsis in Respiratory Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Sepsis is the most common cause of death in non coronary intensive care units (ICUs). In the past 2 decades, the world has witnessed significant increase in the occurrence rate of sepsis (1). In the ICU, sepsis maybe community acquired (already present on admission) or hospital acquired (obtained during ICU stay). This study will add adequate data about incidence and outcome of sepsis in Respiratory Intensive Care Unit. |
ASHRAF A ELMARAGHY; | 2019-11-30 |
| 114 | Evaluation of The Impact of Ascorbic Acid in The Prevention of Vancomycin Induced Nephrotoxicity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A Randomized controlled trial aiming to investigate whether ascorbic acid has a role in preventing vancomycin induced nephrotoxicity or not in critically ill patients. |
NOURAN HESHAM ALI; | 2020-09-01 |
| 115 | Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination By Healthcare-Associated Pathogens PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Extended-spectrum beta-lactamase producing Enterobacteriaceae (EPE), vancomycin-resistant enterococci (VRE) and Clostridium difficile have become a major threat to hospitalised patients worldwide. We hypothesize that receiving inappropriate antibacterial treatment places patients at high risk of intestinal domination and subsequent infection by these bacteria. Further analyses will address cost-effectiveness of specific interventions, behavioural analyses of the decision process leading to inappropriate antibacterial treatment, and the rate of undetected colonization with EPE/VRE/C. difficile on admission. |
MED. JÖRG JANNE VEHRESCHILD; | 2022-07-31 |
| 116 | Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Treatment of Uncomplicated Skin and Soft Tissue Infections PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to compare how well two different antibiotics, doxycycline (DOXY) and trimethoprim/sulfamethoxazole (TMP/SMX), work at curing uncomplicated skin and soft tissue infection (uSSTI) such as 1.Boils (pus in the skin, also known as abscesses and furuncles) or 2. Infections that appear only on the skin surface (called cellulitis and erysipelas) that have pus. |
LOREN G MILLER; | 2025-12-04 |
| 117 | Preoperative Application of Low-level Microcurrent Dressing (Jumpstart) for Decolonization of P. Acnes Before Shoulder Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of the study is to evaluate the efficacy of preoperative treatment with a novel, wireless, low-level microcurrent-generating antimicrobial device (brand name: JumpStart) in preventing the spread of Propionibacterium acnes in patients receiving open or arthroscopic shoulder surgery. |
H MIKE KIM; | 2019-08-01 |
| 118 | Anti-Microbial Effect of Titanium Dioxide Nano Particles Incorporated Acrylic Resin Denture Base Materials in Completely Edentulous Patients: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Although cleaning dentures by immersion in chemical denture cleaning solutions is effective in reducing the number of bacteria, a large number remains adhering to the denture surface. Thus, the mechanical cleansing of dentures is imperative to remove adherent microbes, and prevent diseases. This is not always easy to achieve, due to un-compliant patients, or patients with diminished manual dexterity (e.g. Mani phalanx dysfunction or Rheumatoid Arthritis) that often require assistance in cleaning their dentures, which may not always be available. Therefore, the modification of denture base materials to provide them with antibacterial properties to control oral biofilm formation, … |
MONA MOHAMED IBRAHIM BADRAN; | 2019-01-15 |
| 119 | Longitudinal Changes in Intestinal Microbiota and Its Association With Acquisition of Antimicrobial Resistance in A Cohort of Stroke Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Antimicrobial resistance is regarded as one of the major global public health threats, causing at least 700,000 deaths per year. It has been estimated that if the current problem of antimicrobial resistance is not effectively tackled, it would cause the death of 10 million people worldwide by 2050. Multi-drug resistant pathogen is the single most important contributing factor for inappropriate antibiotics therapy, and this in turn lead to higher mortality in patients with sepsis. The slow pace of development of new classes of antimicrobial agents limits the availability of effective therapy for multi-drug resistant organisms, … |
GRACE LUI; | 2021-12-31 |
| 120 | Investigation Into The Infectivity Levels of Human Papilloma Virus (HPV) in Tonsillar Tissue PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Human Papilloma Virus (HPV) has been shown to be a cause of Head & Neck Squamous Cell Carcinoma (HNSCC) and the majority of current studies focus on what is happening in patients with a HPV HNSCC. But there is limited investigation into HPV infection in the oropharynx of patients who do not have HNSCC. The current incidence of oral HPV infection is not known in the general population locally and there is also limited information on what particular localities within the mouth that patients’ harbour HPV infection what strains are present and if there are any differences in viral load. Therefore the aim of this project is to investigate within patients that undergo tonsillectomies the rate of HPV infection in tonsils to determine the amount of HPV present within the community. |
RAGUWINDER SAHOTA; | 2020-10-01 |
| 121 | Use of Disposable Stethoscope Covers for Reduction of Stethoscope MRSA Contamination Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective pilot study using a randomized, controlled, single blinded, crossover trial design, evaluating the effect of daily antimicrobial stethoscope diaphragm covers versus uncovered stethoscope. Stethoscopes will be cleaned Sani-cloth germicidal disposable wipes which are effective against MRSA. Each participant will then be randomly assigned to 7 days in either the intervention or the control arm. At the end of the 7 days participants stethoscopes will be cleaned again. This will be followed by another 7 days in the arm that they are not in during the first 7 days. The primary endpoint is MRSA colony count from stethoscope diaphragms cultures at 7 days, focusing on the difference between the intervention and the control periods. The secondary endpoint is the rate of hospital acquired MRSA infection in patients treated by residents during each period. |
MARWA MOUSSA; | 2019-04-05 |
| 122 | The Effect of Bathing With Chlorhexidine on MRSA and VRE Colonization in Hematology and Oncology Inpatients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Hospital-acquired infections (HIs) are defined as an infection developed within 48-72 hours of admission to hospital in whom the infection was not incubating at the time of admission to the hospital or an infection acquired in the hospital but appearing 10 days after discharged. Hospital infections threaten patient safety due to the complications they cause, even if they are preventable problems. Staphylococcus aureus and enterococci which cause hospital infections are among the important pathogens in terms of antibiotic resistance development (MRSA: Methicillin-resistant Staphylococcus aureus, … |
GUL HATICE TARAKCIOGLU CELIK; | 2019-08-01 |
| 123 | Risk-factors for Multidrug-resistant (MDR) and Extensively Drug-resistant (XDR) Bacteria Colonization Among Patients at High Risk of STIs PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to identify risk factors and prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria colonization among patients at high risk of STIs |
LAURE SURGERS; | 2019-12-31 |
| 124 | Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients: Randomized and Controlled Multicenter Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, controlled multicenter clinical trial. The purpose of this study is to compare the continuous infusion of vancomycin with intermittent infusion regarding the effectiveness to reach the target serum level and the relationship between infusion type and nephrotoxicity in critically ill patients. |
JULIANO P ALMEIDA; | 2022-12-01 |
| 125 | The Effect of Polyvalent Mechanical Bacterial Lysate on The Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study assesses the effectiveness of Polyvalent Mechanical Bacterial Lysate (PMBL-Ismigen) in reducing nasal methicillin-resistant Staphylococcus aureus (MRSA) colony growth in children with pollen allergic rhinitis (AR) aged 5 to 17. Half of the participants received PMBL and the other half received a placebo. |
KAMIL JANECZEK; | 2020-08-31 |
| 126 | STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the micro-biologic efficacy and safety of a streamlined treatment for early onset methicillin-resistant staphylococcus aureus (MRSA) in patients with cystic fibrosis. |
MARIANNE MUHLEBACH; | 2026-02-17 |
| 127 | Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis: A Prospective Randomized Placebo-controlled Double-blind Multicenter Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Antimicrobial treatment could be beneficial in patients with ventilator-associated tracheobronchitis (VAT). The hypothesis of this study is that antibiotic treatment for VAT (3 or 7 days), compared with no antibiotic treatment, would reduce the incidence of transition from VAT to ventilator-associated pneumonia (VAP). |
SAAD NSEIR; | 2025-12-11 |
| 128 | Vancomycin De-escalation Therapy in Patients With Pneumonia and Negative MRSA Nasal Swab PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a non-inferiority study evaluating clinical improvement rate when using MRSA nasal swabs to guide discontinuation of vancomycin for empiric coverage for MRSA pneumonia. |
RAYAN IHLE; | 2023-12-30 |
| 129 | Dalbavancin For The Treatment Of Gram Positive Osteomyelitis Or Joint Infections Including Prosthetic Hip Or Knee Infections PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Because of its prolonged terminal half-life, dalbavancin is an extremely attractive option in treating Gram-positive infections caused by S. aureus including MRSA, and streptococcal species. Systemic bacterial infections due to Staphylococci such as osteomyelitis and septic arthritis, are conditions which require prolonged IV therapy, typically for at least 3-6 weeks, though sometimes more. Due to dalbavancin’s prolonged terminal half-life, it may offer the opportunity to substantially reduce costs and morbidity in native joint and prosthetic joint infections with one infusion every fourteen days until completion of therapy. |
DONALD PORETZ; | 2022-12-01 |
| 130 | Use of Aaerosol Combined With Intravenous Antibiotics for The Treatment of Multidrug Resistant GNB Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To investigate use of aerosol combined with intravenous antibiotics for the treat of multi-drug resistance gram negative bacterias diagnosed ventilator-associated pneumonia in intensive care unit in a hospital. |
SHENG WANG MD PHD; | 2020-01-01 |
| 131 | A Randomized, Double-Blind, Placebo-Controlled Trial of The Efficacy of Retapamulin As A Topical Decolonizing Agent for Mupirocin Resistant Methicillin Resistant Staphylococcus Aureus (MRSA) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate the efficacy of retapamulin to reduce carriage of MRSA via a randomized, double-blind, placebo-controlled clinical study testing retapamulin among patients with confirmed mupirocin-resistant nasal and/or rectal MRSA colonization. The sample size will include 27 subjects in each of the two arms of the study (retapamulin versus placebo) for a total of 54 subjects. Participants who are found to be nasal and/or rectal colonized with MRSA will be randomized to receive either retapamulin or placebo applied nasally and rectally for a total of 5 days. Nasal and rectal swabs will be collected at pre-defined time points during study duration (screening swab, swab one week after completion of topical therapy, swab 4 weeks after completion of topical therapy) to assess MRSA colonization status. The colonization rates of both groups will be assessed via Fisher’s Exact Test. |
JENNIFER LIGHTER; | 2019-03-18 |
| 132 | Lipidome and Microbiome Profile of The Eye in Rosacea PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The question that the investigators aim to address in this proposal is how the local lipid mediator profiles of ceramides and eicosanoids are altered in cutaneous and ocular rosacea and how antibiotics alter the lipidome. The investigators also seek to understand how the microbiome is changed in those with and without rosacea, and how the microbiome is altered in those with rosacea. Understanding how the lipidome is modulated in rosacea with antibiotic treatment will serve as the first step in targeting therapies toward directly altering the lipidome to reduce inflammation and ultimately reduce the use of antibiotics. |
RAJA SIVAMANI; | 2022-12-01 |
| 133 | Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia (RAPIDS-GN) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: RAPIDS-GN is a multi-center, prospective, randomized, controlled trial to evaluate the following strategies for patients with confirmed gram-negative bacillus bacteremia (GNB): 1. Standard culture and antimicrobial susceptibility testing (AST); or 2. Rapid identification and AST using the Accelerate PhenoTest™ BC Kit, performed on the Accelerate Pheno™ System (AXDX) |
DUKE UNIVERSITY | 2018-11-30 |
| 134 | A Phase III, Randomized, Double-blind, Placebo-controlled Study of AeroVanc for The Treatment of Persistent Methicillin-resistant Staphylococcus Aureus Lung Infection in Cystic Fibrosis Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multi-center, randomized phase III study to evaluate the clinical effectiveness of AeroVanc in persistent methicillin-resistant Staphylococcus aureus (MRSA) infection in patients with cystic fibrosis (CF). |
PATRICK FLUME; | 2021-01-15 |
| 135 | Comparison of Standard Isolation With Targeted Isolation for Preventing Nosocomial Transmission of MRSA and VRE: A Pilot Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Hospital-acquired infections are common and frequently lead to poor outcomes, including death, in affected patients. Two common organisms that cause infections in the hospital are methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). One strategy used to prevent these infections is contact isolation of hospitalized patients with MRSA and/or VRE. It is unclear whether contact isolation decreases the rate of infection with MRSA and/or VRE. The CONTACT-PILOT study is designed to test the hypothesis that contact isolation decreases the rate of infection with MRSA and/or VRE in patients in the intensive care unit (ICU). The study will enroll all adults in the Medical ICU and will run between September 2017 and April 2018. During some months, all patients in the Medical ICU patients will be placed in isolation for MRSA or VRE if they have a current infection or colonization with either organism, or a recent history thereof. During other months, patients will only be placed in isolation for MRSA or VRE if they have an active, highly-transmissible infection with either organism, such as a pneumonia or an open, draining wound. |
TODD RICE; | 2018-05-30 |
| 136 | Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label, single center, prospective study of patients with a diagnosis of cystic fibrosis (CF) and a history of methicillin-resistant Staphylococcus aureus (MRSA), also known as oxacillin-resistant Staphylococcus aureus (ORSA), … |
ALEXANDER VINKS; | 2025-09-05 |
| 137 | The Efficacy of Topical Povidone – Iodine Rinses in The Management of Biofilm-associated Chronic Rhinosinusitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Povidone Iodine solution is a nasal antiseptic. Its application has been shown to be clinically safe, tolerable and effective against bacteria and fungi associated with chronic rhinosinusitis. This study will evaluate the effectiveness of Povidone Iodine in this hard-to-treat patient group. Furthermore, the study will also further evaluate any side effects that may occur with the use of Povidone Iodine. |
AMIN JAVER; | 2019-08-31 |
| 138 | Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated Infection PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The objective is to conduct a prospective, sham controlled, double-blinded, interventional crossover trial to compare standard terminal cleaning plus PX-UV (intervention) with standard terminal cleaning plus sham PX-UV (control) with crossover at 12 months, following a 6-month washout period. Outcome measures include the rates of HAIs, … |
KEITH KAYE; | 2020-04-15 |
| 139 | A Multi-level Antimicrobial Surface Coating for A Healthier Environment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project aimed to study the use of the multi-level antimicrobial coating in a working hospital environment. Patient privacy curtains from a public sector hospital were coated and installed in rehabilitation ward in comparison of normally washed curtains in the same setting and compared the mean reduction on both control and treatment end to assess the effectiveness of coating against hospital acquired infections including multidrug resistant organisms (MDROs). |
KING LUN YEUNG; | 2018-06-30 |
| 140 | Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) – Point-of-care-testing (POCT) in Clinical Decision Making PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The study EPICS-6 consists of three study phases. Emergency Department patients are screened for nasal and pharyngeal colonisation with Methicillin sensitive and Methicillin resistant Staphylococcus aureus (MSSA/MRSA) using a point-of-care (POC)-PCR-testing method (cobas®LIAT®-System, Roche Molecular Systems Inc.) The first aim of this study is to describe the prevalence of MSSA/MRSA-colonisation in a routine cohort of Emergency Department patients. The second aim is to determine the impact of POC-guided decolonisation as compared to conventional laboratory testing on in-hospital infection rates with MSSA/MRSA in a pre-post-comparison study. |
MARTIN MOECKEL; | 2018-08-01 |
| 141 | Cluster-randomized Non-inferiority Trial Comparing Mupirocin Vs Iodophor for Nasal Decolonization of ICU Patients to Assess Impact on S. Aureus Clinical Cultures and All-cause Bloodstream Infection During Routine Chlorhexidine Bathing PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The Swap Out Trial is a cluster randomized controlled trial of HCA hospitals, evaluating the non-inferiority of two decolonization regimens: Arm 1 Routine Care: ICU nasal decolonization with mupirocin twice daily for 5 days in the context of chlorhexidine for daily bathing; Arm 2 Intervention: ICU nasal decolonization with iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing Note: that enrolled subjects represents 137 individual HCA Hospitals (representing ~235 ICUs) that have been randomized. |
RICHARD PLATT; | 2024-12-01 |
| 142 | Randomized Clinical Trial to Assess Whether The Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL By Antiretroviral Treatment Influences The Rate of Carriage of Multidrug-resistant Bacteria PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis pneumonia and other infections in HIV positive patients with low immunity. Common clinical practice is to start CPT in any patient with CD4 counts below 200/µL, and, conversely, to stop CPT when immunity has been restored by antiretroviral treatment to CD4 counts above 200/µL or when viral suppression has been documented for 3 months. However, the latest WHO guidelines widely expands the indication for CPT by advocating for settings with high prevalence of malaria and bacterial infections, … |
JOEL MANYAHI; | 2019-07-25 |
| 143 | Derma-Stent Novel Abscess Packing Device (Pilot Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In this research study, a device called the Derma-Stent will be tested. The sponsor of the study, Mar-Med Company, will supply the device. This device is used to drain a cutaneous abscess, which is a skin infection that results in buildup of pus under the skin. Currently, the normal treatment for this abscess is to cut and drain and the wound, and later pack the wound with gauze. Packing is done to prevent the pus to accumulate again. But regular gauze is difficult for patient to remove themselves, … |
AARON BRODY; | 2017-12-15 |
| 144 | Tolerability, Safety, and Efficacy of Tedizolid As Oral Treatment for Bone and Joint Infections PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The problem of interest is that doctors are looking for new antibiotic treatments for bone and joint infections. Treatment for bone and joint infection is not standardized, which allows a wide range of antibiotic therapy to potentially be given. A type of bacteria called S. aureus is the most common cause of bone and joint infection. Methicillin resistant S. aureus (MRSA) is a type of bacteria that is not killed by some antibiotics, and it is increasingly common in U.S. and non-U.S. medical centers. This problem will be studied by investigating whether an antibiotic called tedizolid is tolerable, … |
LOREN G MILLER; | 2022-01-01 |
| 145 | Community-associated Staphylococcus Aureus Infections in China: Epidemiology, Molecular Characteristics, Treatment, and Outcome PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), strains of MRSA that are able to infect otherwise healthy people outside of hospital settings, emerged in the late 1990s and have recently arisen in many countries around the globe. CA-MRSA strains are usually distinguished from their HA-MRSA counterparts by the following characteristics: Firstly, CA-MRSA strains are usually susceptible to non-lactam antibiotics. Secondly, CA-MRSA harbors type IV and V SCCmec elements, which are shorter than the traditional type I, II, and III SCCmec elements found in HA-MRSA strains. Thirdly, … |
JIAN-CANG ZHOU M.D.; | 2018-06-30 |
| 146 | A Phase 3, Multicenter, Randomized, Double-Blind, Comparator-Controlled Study to Evaluate The Safety and Efficacy of Intravenous to Oral Delafloxacin in Adult Subjects With Community-Acquired Bacterial Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety and efficacy of delafloxacin compared to moxifloxacin in the treatment of adult patients with community-acquired pneumonia. |
MELINTA THERAPEUTICS | 2018-08-07 |
| 147 | The First in The World Human Proof-of-concept Study on Disinfection and Healing Acceleration Capabilities of 222nm Wave Length Narrow Band Ultraviolet Lighting Device PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The threat of MRSA and multi-drug resistant pathogens have been growing in recent years. A new means of countering the infectious threat is required and one such modality is the use of UV light for disinfection. The aim of the study is to proof the efficacy of the 222nm UV light in disinfection on patients with sacral sores. This is a first in human proof-of-concept study |
NATIONAL UNIVERSITY HOSPITAL SINGAPORE | 2019-01-23 |
| 148 | A Prospective, Single Center, Randomized, Double-blind, Placebo Controlled Study in Two Phases to Evaluate The Safety and Efficacy of ATx201 As A Topical Antibiotic Agent PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: AntibioTx is developping ATx201 as a topical product for treatment of skin infections, including infected atopic dermatitis. |
MARKUS ZEITLINGER; | 2018-03-01 |
| 149 | Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery: A Double Blinded Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. With the increasing rate of identified P. acnes shoulder surgery infection despite the use of recommended skin preparation and preoperative prophylactic antibiotics, a question arises; Is Cefazolin the most effective prophylactic antibiotic for shoulder surgery? The objective of this study is to determine if Ceftriaxone is superior to Cefazolin as a prophylactic antibiotic for skin colonization with P. acnes in primary shoulder surgery |
DOMINIQUE ROULEAU; | 2025-08-08 |
| 150 | Evaluation of The Effect of Platelet Rich Plasma (PRP) on The Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair By Modified Millard Cheiloplasty: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate effect of platelet rich plasma on scar formation of unilateral cleft lip repair. |
SHAIMAA MOHSEN; | 2018-02-01 |
| 151 | Investigation of The Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Linezolid is the second line agent in the treatment of MRSA and PRSP infections, and it is also the drug of choice for VRE infections. It can be an alternative option against multidrug resistant tuberculosis and non-tuberculosis mycobacterium. However, Patients who receive more than 2 weeks of treatment duration and who have renal dysfunction or severe cirrhosis may prone to experience anemia, thrombocytopenia, and leukopenia. Long-term use may also result in lactic acidosis, peripheral neuropathy and optic neuropathy due to mitochondrial toxicity. Thus, … |
SHU-WEN LIN; | 2023-12-31 |
| 152 | The Use of Clinell Universal Wipes, Clinell Sporicidal Wipes, and Clinell EvaluClean Fluorescent Marker System, in Reducing Environmental Contamination and Acquisitions of Multidrug Resistant Organisms and Hospital Acquired Infections PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Multidrug resistant organisms (MDRO) are prevalent in hospitals and are associated with hospital-acquired infections (HAI). High-touch surfaces serve as reservoirs and fomites for MDRO transmission. The investigators quantified the impact of hanging single-use cleaning/disinfecting wipes in patients’ immediate environment within multi-patient rooms. Pre-specified outcomes were: 1) HAI rate, 2) cleaning frequency, 3) MDRO room contamination, 4) new MDRO acquisitions, and 5) in-hospital mortality. |
DROR MARCHAIM; | 2018-01-19 |
| 153 | Randomized Controlled Trial of Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in A Neonatal Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine whether or not mupirocin treatment results in S. aureus decolonization in affected NICU patients. |
MELISSA NELSON; | 2019-12-01 |
| 154 | Therapeutic Monitoring of Vancomycin in Critical Ill Patients: A Registry PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Vancomycin is a glycopeptide antibiotic that is the first line antibiotics for the treatment of serious gram-positive infections involving methicillin-resistant Staphylococcus aureus (MRSA). Its therapeutic window is narrow, so there is a need to monitor serum vancomycin concentration in clinical practice, especially in the critically ill patients. So far, few studies have investigated the clinical outcomes of the dosage strategy that vancomycin dosage is administered and adjusted individually using PPK and Bayesian methods based on observed concentrations. The objective of this study is to investigate the effectiveness, safety and economics of the vancomycin individualized dosing service provided by pharmacists. |
QINGGANG GE; | 2019-12-01 |
| 155 | A Comparative Efficacy Study of Vancomycin Dosage Adjustment By Equation-based Method and Vancomycin Trough Concentration Method for Treatment of Infections Caused By Methicillin Resistant Staphylococcus Aureus PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: An open-label randomized controlled trial to compare two vancomycin dosage adjustment methods |
PINYO RATTANAUMPAWAN; | 2018-09-01 |
| 156 | Evaluation of The Effectiveness of Chlorhexidine Bathing in Reducing Nosocomial Infections in The Neonatal Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, controlled; crossover study of daily bathing with no-rinse, 2% chlorhexidine gluconate (CHG) impregnated washcloths versus bathing with water/soap or water according to gestational age and weight (e.g. standard bathing). The trial will take place in the Neonatal intensive care unit (NICU). Baseline data ragarding bloodstream infections (BSI) and colonization with multidrug resistant orgnisms (MDRO) will be collected for 3-6 months prior to patient enrollment. In the preliminary phase of the study we will establish the safety of chlorhexidine bathing using Clinell ® Chlorhexidine wash cloths on three groups of patients: term infants admitted to the NICU; … |
MASKIT BAR-MEIR; | 2020-10-01 |
| 157 | A Phase 3, Randomized, Double-Blind, Double-Dummy Study to Compare The Efficacy and Safety of Oral Lefamulin (BC 3781) Versus Oral Moxifloxacin in Adults With Community-Acquired Bacterial Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the safety and efficacy of lefamulin, a pleuromutilin, for the treatment of adults with moderate community-acquired bacterial pneumonia |
NABRIVA THERAPEUTICS AG | 2018-01-01 |
| 158 | Impact of Daily Bathing With Chlorhexidine in The Critical Patient: Colonization and Environment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The search for preventive measure with daily bathing with chlorhexidine in the critical care patient will result in a reduction in patient colonization with multidrug resistant pathogens. Thus, preventing healthcare associated infections. The aim of this study was to determine the impact of daily bathing with chlorhexidine in patient colonization, environment and healthcare workers in the medical intensive care unit (MICU). The study will be conducted at the University Hospital Dr. José Eleuterio González, a 450-bed teaching hospital in Monterrey, northeast Mexico. This is a prospective, experimental, randomized, open-label, … |
MICHEL FERNANDO MARTINEZ-RESENDEZ; | 2017-10-01 |
| 159 | Admission Toxigenic C. Difficile Surveillance to Reduce Hospital Onset C. Difficile Infection (CDI) PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Clostridioides (formerly Clostridium) difficile Infection (CDI) is a persistent healthcare issue. In the US, CDI is the most common infectious cause of hospital-onset (HO) diarrhea. Objective: Assess the impact of admission testing for toxigenic C. difficile colonization on the incidence of clinical disease. Design: Pragmatic stepped-wedge Infection Control initiative. Setting: NorthShore University HealthSystem (NorthShore) is a four-hospital system near Chicago, … |
NORTHSHORE UNIVERSITY HEALTHSYSTEM | 2018-12-31 |
| 160 | Staphylococcus Aureus Resistant to Methicillin (MRSA) Screening in Trauma Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this study and to know the incidence of healthy carriers of Staphylococcus aureus resistant méti- patients supported for fracture of the proximal femur . This assessment will be made preoperatively by a nasal sampling and analysis through it by rapid Polymerase Chain Reaction method GeneXpert® . |
NICOLAS REINA; | 2018-12-15 |
| 161 | Does UROSHIELD® Influence Bacterial Growth On Endotracheal Tubes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to examine the effect of UROSHIELD® (a device which generates low energy ultrasound waves) on development of bacterial colonies on endotracheal tubes, in patient receiving mechanical ventilation, and to determine whether this device lowers the rate of bacterial resistance to antibiotics. |
REUVEN FRIEDMANN; | 2018-12-01 |
| 162 | Swiss PACK-CXL (Photoactivated Chromophore for Infectious Keratitis Cross-linking) Multicenter Trial for The Treatment of Infectious Keratitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To assess the safety and efficacy of PACK-CXL (photoactivated chromophore for infectious keratitis cross-linking) as a firstline treatment for infectious corneal infiltrates and early corneal ulcers, and compare it to the current standard of care, antimicrobial therapy. |
FARHAD HAFEZI; | 2020-10-01 |
| 163 | Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Vancomycin is the standard first-line treatment for MRSA infections and a first-line empiric therapy. The relationship between exposure to vancomycin and efficacy is admitted but because of an important intersubject variability, therapeutic exposure isn’t usually achieved. The primary aim of this randomized controlled trial is to evaluate a new early dosage adjustment strategy of vancomycin in children, comparing it to the usual treatment strategy. Using a bayesian approach, … |
JEAN-MARC TRELUYER; | 2026-03-27 |
| 164 | MRSA Eradication and Decolonization in Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, the investigators intend to compare therapies (abscess surgery and hygiene education compared to abscess surgery and hygiene education followed by decolonization) for Methicillin-Resistant Staphylococcus Aureus skin and soft tissue infections (MRSA SSTI) to determine which is the more effective treatment. The investigators focus on patient centered outcomes as described by the families of MRSA infected patients. Such outcomes are likely to include quality of life, side effects, … |
PAUL MUSEY; | 2019-02-01 |
| 165 | Comparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA Related Papers Related Patents Related Grants Related Experts Highlight: To determine if routinely available 10% povidone-iodine swabs are more effective than saline and 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP for decolonizing MRSA. |
ROTHMAN INSTITUTE ORTHOPAEDICS | 2016-02-01 |
| 166 | An Innovative Approach to Understanding and Controlling Transmission of HAIs PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the impact of copper linens on hospital acquired infections and drug resistant bacteria. |
EBBING LAUTENBACH; | 2022-12-01 |
| 167 | Rapid Diagnostic Testing to Guide Antibiotic Therapy in Drug Resistant Pneumonia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to conduct a randomized clinical trial to compare an antibiotic strategy based on a novel diagnostic test, polymerase chain reaction (PCR) to usual care, in critically ill adults with pneumonia suspected to be caused by methicillin resistant staphylococcus aureus (MRSA). The investigators hypothesize that when automated PCR is used to guide antibiotic therapy, antibiotic exposure will be reduced in critically ill subjects with pneumonia. |
RICHARD WUNDERINK; | 2019-05-03 |
| 168 | Ultra Violet-C Light Evaluation As An Adjunct to Removing Multi-Drug Resistant Organisms (UVCLEAR-MDRO) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study examines the impact of UV-C light disinfection as an adjunct to routine daily and discharge patient room cleaning on patient infection and colonization with hospital associated bacteria. Patient rooms are counted as enrolled since consent was waived and the number of participants is unknown. Total of 83 rooms. |
LISA MARAGAKIS; | 2018-02-01 |
| 169 | Randomized, Double Blind, Placebo-controlled Study of The Safety, Tolerability and Pharmacokinetics After Single Ascending Doses or Multiple Ascending Doses of OSCN-, BLF or ALX-009 in Healthy Male and CF and Non-CF Bronchiectasis Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 1, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability and pharmacokinetics of a single ascending doses (SAD) and multiple ascending doses (MAD) of Hypothiocyanite (OSCN-), bovine lactoferrin (bLF) and their combination (ALX-009) in healthy male volunteers and patients suffering from cystic fibrosis (CF) and non-CF bronchiectasis (NCFBE). |
ISABELLE DURIEU; | 2021-12-01 |
| 170 | A Multi-center Prospective Randomized Open Label Study of Utilizing Interleukin 10 (IL-10) Levels As A Guide for Antibiotic Selection for Methicillin Resistant Staphylococcus Aureus Bacteremia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Patients with MRSaB have high therapeutic failure rates and mortality rates. Recent studies have shown that an elevated IL-10 level is an independent risk factor of mortality. It may also serve as biomarker for very early risk stratification. The aim of this study is to compare the outcomes for patients with elevated IL-10 levels (≥8 pg/ml) when treated with standard antibiotic therapy (daptomycin or vancomycin) versus early aggressive therapy (daptomycin with ceftaroline) for the treatment of MRSaB. |
MATTHEW GERIAK; | 2018-01-30 |
| 171 | Integrating Personal and Household Environmental Hygiene Measures to Prevent Methicillin-Resistant Staphylococcus Aureus Infection PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators propose a pragmatic comparative effectiveness trial evaluating several decolonization strategies in patients with Staphylococcus aureus infection, their household contacts, and household environmental surfaces. The central hypothesis of this proposal is that an integrated approach of periodic personal and household environmental hygiene will reduce S. aureus transmission in households and subsequently decrease the incidence of skin and soft tissue infections (SSTI). |
STEPHANIE A. FRITZ; | 2026-02-24 |
| 172 | Prophylactic Negative Pressure Wound Therapy in Obese Women After Cesarean: A Pilot Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Surgical site infections (SSIs) complicate 5 – 12% of cesareans. Negative pressure wound therapy (NPWT) – a closed, sealed system that applies negative pressure to the wound surface – has been used to treat open wounds since the late 1990s. Experimental evidence suggests NPWT promotes wound healing by removing exudate, approximating the wound edges, and reducing bacterial contamination. Although effectiveness of prophylactic NPWT is biologically plausible and non-randomized studies suggest benefit in reducing SSIs, … |
METHODIUS G TUULI; | 2016-03-01 |
| 173 | Patient-Centered Comparative Effectiveness Research (CER) Study of Home-based Interventions to Prevent CA-MRSA Infection Recurrence PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The overall goal of the project is to develop and evaluate a home-based intervention to prevent re-infection and transmission of Community-Acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA) in patients presenting to primary care with skin or soft tissue infections (SSTIs). Centers for Disease Control (CDC) CA-MRSA guidelines include incision and drainage, antibiotic sensitivity testing and antibiogram-directed prescribing. Re-infections are common, ranging from 16% to 43%, and present significant challenges to clinicians, … |
JONATHAN N TOBIN; | 2018-12-31 |
| 174 | Decolonization of The Oropharynx, An Important and Neglected Reservoir of S. Aureus Colonization PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The problem of interest is the high rate of recurrent SSTIs in children caused by S. aureus despite the use of systemic antibiotic treatment, due to difficulties in decolonization and the prevalence of antibiotic-resistant strains such as MRSA. This problem will be studied through a randomized, double-blind, placebo-controlled clinical trial of the use of a 0.12% clorhexidine gluconate (CHG) oral rinse in decolonizing S. aureus in the oropharynx in children 5-17 years old. CHG is an excellent candidate for use in children as its safety has been widely established, and it is readily commercially available. Eligible, … |
LOREN G MILLER; | 2017-11-01 |
| 175 | A Phase 3, Randomized, Double-Blind, Double-Dummy Study to Compare The Efficacy and Safety of Lefamulin (BC 3781) Versus Moxifloxacin (With or Without Adjunctive Linezolid) in Adults With Community-Acquired Bacterial Pneumonia PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the safety and efficacy of lefamulin, a pleuromutilin, for the treatment of adults with moderate to severe community-acquired bacterial pneumonia. |
NABRIVA THERAPEUTICS AG | 2017-05-01 |
| 176 | Prevention of Healthcare Associated Infections in Bone Marrow Transplant Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study involves sampling bone marrow transplant patients, hospital workers and the patient room for microbes using swabs and other techniques. We send these samples to the laboratory, where they will use state-of-the art technology to identify and relate the microbes to each other. This study also involves putting copper, nickel, or titanium into some hospital rooms, and seeing whether these metals influences the growth of microbes. Some equipment in the hospital room, such as faucets and soap dispensers will be replaced by sensor-based (e.g. touchless) controls. |
LINDA HOANG; | 2018-03-01 |
| 177 | CAMERA 2 – Combination Antibiotic Therapy for Methicillin Resistant Staphylococcus Aureus Infection – An Investigator-initiated, Multi-centre, Parallel Group, Open Labelled Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this clinical trial is to determine whether a novel combination antibiotic treatment (vancomycin/daptomycin + beta-lactam) is superior to the standard antibiotic treatment (vancomycin/daptomycin) for hospitalised adults with Methicillin Resistant Staphylococcus aureus bacteraemia. The hypothesis is that the addition of beta-lactam antibiotics (these are antibiotics from the penicillin family) to the standard therapy will lead to more efficient bacterial killing and hence lead to faster clearance of bacteria from the blood stream and other areas of infection, thereby reducing the risk of the spread of infection and death. The study design is an investigator-initiated, multi-centre, open-label, … |
JOSHUA DAVIS; | 2018-10-24 |
| 178 | Molecular Epidemiology and Phylodynamic and Phylogeographic Analysis of Community-associated Methicillin-resistant Staphylococcus Aureus (CA-MRSA) Transmission: An Emergency Department Population Sampling Strategy PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Given that the Emergency Department (ED) has become the entry way for large populations of patients into the health care system, a strategy of sampling MRSA isolates in ED populations and merging this information with patient-level data may present a window to hypothesize and investigate CA-MRSA transmission within the community and its impact on hospital-acquired infections. |
JOSEPH A TYNDALL; | 2022-02-01 |
| 179 | Impact of The Introduction in A Heart Surgery ICU of A PCR Technique (Cepheid Xpert® SA Nasal Complete Assay) to Identify Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus in Nasal and Respiratory Tract Samples PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In patients on mechanical ventilation, it is not known whether the identification of S. aureus in LRT samples improves the performance of its nasal detection. To assess the MSSA or MRSA carrier status of patients requiring mechanical ventilation for more than 48 hours after major heart surgery: comparing the performance of the diagnostic technique Xpert® SA Nasal Complete assay in nasal swab and LRT samples. |
EMILIO BOUZA; | 2016-04-01 |
| 180 | Antimicrobial Activity of A Quaternary Ammonium Methacryloxy Silicate-containing Acrylic Resin: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: One of the major challenges in orthodontic treatment is long-term stability. Because removable retainers are worn for at least one year, bacteria and fungi may accumulate on the retainers in the form of multi-species plaque biofilms. This may result in increased incidence of proximal dental caries or oral candida infection. Thus, … |
FRANK TAY; | 2016-01-01 |
| 181 | TRI-STAR: Initial and Chronic MRSA Infection in CF (TRanslational Investigation of STaph. Aureus Resistance) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to examine features of MRSA that are associated with chronic MRSA infection and bacterial persistence despite IV antibiotic therapy. Subjects are asked to expectorate sputum and complete CF symptom diaries both at beginning and end of IV therapy. |
MARIANNE S MUHLEBACH; | 2021-12-01 |
| 182 | Steady-State Pharmacokinetics of Tedizolid in Plasma and Sputum of Patients With Cystic Fibrosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed study is designed to characterize the pharmacokinetics of intravenous and oral tedizolid in patients with Cystic Fibrosis. |
PAUL BERINGER; | 2017-12-31 |
| 183 | Phase 2 Study Evaluating The Kinetic Properties of An Autologous Microbiome Transplant in Adult Atopic Dermatitis Patients Related Papers Related Patents Related Grants Related Experts Highlight: Unlike healthy control skin, the skin of patients with atopic dermatitis (AD) is frequently colonized by Staphylococcus aureus (S. aureus), putting these patients at increased risk of S. aureus skin infections. In addition, research in the investigator’s lab has shown that these patients have fewer protective Staphylococcal species such as Staphylococcus epidermidis (S. epidermidis) that are known to produce antimicrobial peptides that play a role in protecting the skin from invading pathogens. In this study, … |
RICHARD GALLO; | 2022-07-01 |
| 184 | ANti-infective Stewardship Using The Wisca Tool in The Electronic Medical Record PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: Beginning in the mid-to late 1980s and accelerating through the 1990s and 2000s the shield of antibiotic invincibility began to crack sufficiently so that it was apparent to everyone we faced a serious problem. The investigators will demonstrate and expand the use of information technology based on the ingenious weighted-incidence, syndromic, combination antibiogram (WISCA) tool for the widespread use of automated clinician prompts enhancing empiric antibiotic therapy as part of a comprehensive infection control stewardship program that reduces antibiotic resistance. This research program will demonstrate that use of such a tool lowers mortality, improves outcome, … |
LANCE R PETERSON; | 2019-06-30 |
| 185 | Prevalence of S. Aureus Among Patients Presenting With Skin and Soft Tissue Infections: A Multi-centre Pilot Study in Europe PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Methicillin-resistant Staphylococcus aureus (MRSA) is reported as one of the main causative pathogen of community acquired SSTIs. In the USA, high prevalence of MRSA among Skin and soft tissue infections (SSTIs) is known to be due to the spread of the USA300 clone [Moran et al. 2006]. Among S. aureus SSTIs infections in Europe, data regarding the prevalence of MRSA in SSTIs and the causative genotypes remain scarce. The paucity of literature on the prevalence of MSSA, … |
FRANÇOIS VANDENESCH; | 2015-08-01 |
| 186 | Effect of Antibiotics on Community-Associated Staphylococcus Aureus Colonization and Recurrent Infection in Patients With Uncomplicated S. Aureus Skin Abscesses PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Infections due to S. aureus are a major healthcare burden. Currently there is not an effective way to prevent S. aureus infection. Treatment failure can happen in up to 20% of patients with SSTI and mean additional cost per patient can be over $1500. Antibiotics are often prescribed for the treatment of CA-S. aureus SSTI. Current IDSA CA-MRSA guidelines suggest that incision and drainage alone may be adequate for management of uncomplicated CA-S. aureus skin abscesses and there is uncertainty about the need of antibiotics. It is not known whether antibiotics are helpful in decreasing S. aureus colonization rates or preventing future S. aureus infections. Though resolution of acute abscess after drainage may be unchanged by antibiotic administration, the impact of managing S. aureus abscess without antibiotics on ongoing S. aureus colonization and recurrent infection requires further study. This study seeks to examine whether the management of initial S. aureus abscesses with incision and drainage in addition to antibiotic therapy is an effective means of preventing recurrent infection. The prolonged longitudinal follow-up of this study is another unique characteristic that will enable the investigators to capture data about recurrences of infections. |
MARCELA RODRIGUEZ; | 2017-09-01 |
| 187 | DExterous Hand Control Through Fascicular Targeting (DEFT) – (Human Subjects) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Our goal is to temporarily implant the following groups for 540 +/- 30 days: 1. Forearm FAST electrodes 1. Five human partial hand amputees (amputated at the level of the hand) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve. 2. Five human hand and forearm amputees (amputated at the level of the forearm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve . 2. Arm FAST electrodes 1. Five human partial hand amputees (amputated at the level of the hand) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve. 2. Five human hand and forearm amputees (amputated at the level of the forearm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve. 3. Five human hand, forearm and arm amputees (amputated at the level of the arm) with 2 FAST electrodes in the ulnar nerve and 2-5 FAST electrodes in the median nerve. |
JONATHAN CHENG; | 2026-03-05 |
| 188 | A Randomized, Multicenter, Double-Masked, Placebo-Controlled, Phase 3 Study to Evaluate The Safety and Efficacy of Vancomycin Hydrochloride Ophthalmic Ointment 1.1% in Patients With Moderate to Severe Bacterial Conjunctivitis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 3 study to evaluate the safety and efficacy of a vancomycin hydrochloride ophthalmic ointment dosed 4 times daily for 7 days compared to placebo (vehicle) in patients with moderate to severed Gram-positive bacterial conjunctivitis. |
KUROBE | 2018-05-31 |
| 189 | Effect of MVX (Titanium Dioxide) on The Microbial Colonization of Surfaces in An Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Environmental cleanliness As antimicrobial resistance is a major and overall deteriorating public health problem international cooperation is necessary. Continued progress is needed to implement and improve programmes for the prevention and control of antimicrobial resistance and HAIs. Environmental cleanliness might be one of the most important initiatives to reduce HAIs. Hospital surfaces are heavily contaminated with bacteria with the highest numbers on surfaces closest to the patients. Bed rails, nurse call buttons, curtains, towel dispensers, door handles, sinks, floors, clinical information stations, medical devices, stethoscopes, staff toilets etc. Actually, … |
DRS. B. DE JONG; | 2016-05-01 |
| 190 | IDC 56: A Randomized Double-blinded Study Comparing Ceftaroline to Standard of Care Therapy With Cefazolin and Vancomycin As Surgical Prophylaxis for High Risk Orthopedic and Cardiac Surgeries PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a randomized double-blinded study comparing ceftaroline to standard of care therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and cardiac surgeries. Study participants will be enrolled from those undergoing cardiothoracic surgery involving sternotomy and those undergoing prosthetic joint replacement of either hip or knee. Consenting patients will be randomized 2:1 to receive either ceftaroline or cefazolin/vancomycin. This study will be blinded by the use of placebo vancomycin infusions and placebo cephalosporin infusions. The primary end point will be the development of a surgical site infection within 30 days of surgery. |
GEORGE SMULIAN; | 2017-06-01 |
| 191 | The Pharmacokinetics and Pharmacodynamics of High-dose Daptomycin in Patients With Septic Shock PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The first objective of this study was to characterize the pharmacokinetics and pharmacodynamics of daptomycin with a daily dose of 12mg/kg in septic shock patient; the second objective is to identify the optimal dosing scheme for daptomycin among patients with septic shock and to enhance therapeutic outcomes. |
YINGZI HUANG; | 2016-06-01 |
| 192 | A New Method for Detection of Bacteria in The Bloodstream PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim is to determine if this new technique will detect and identify bacteria in the blood sooner than standard blood cultures or identify patients who may be septic without growing bacteria in their cultures. These will be correlated with the data collected from medical records on presumed sepsis. These results will be linked to data concerning infection that will be available as part of routine care including blood counts and other laboratory values that would be part of the routine medical care such as a white blood cell count. The earlier the bacteria are identified and the appropriate antimicrobials are administered the better the patient outcome. |
BRENDA FAHY; | 2022-03-04 |
| 193 | Vitamin D Supplementation to Persistent Carriers of MRSA – A Double Blind, Randomised Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to treat persistent MRSA carriers with vitamin D supplementation during a 12 month to see if the number of MRSA positive patients can be reduced. |
PETER BERGMAN; | 2017-12-01 |
| 194 | Human Immunity Against Staphylococcus Aureus Skin Infection PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: – Staphylococcus aureus, or staph, is commonly found on the skin and in the respiratory system. Sometimes people who get sick with staph infection do not get better with standard treatment. These staph infections can be serious and even deadly. Researchers want to find out why some people are more likely to get the infection. Objectives: – To look at the immune response of the skin when it is exposed to bacteria. Eligibility: – People age 2 65 with hyper IgE syndrome (HIES) and those with recurrent staph infections. – Healthy volunteers. Design: – … |
IAN A MYLES; | 2019-04-24 |
| 195 | Topical Vancomycin for The Reduction of Surgical Site Infections in Neurosurgery PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures. Adult patients undergoing neurosurgery at either institution will be eligible for participation in this randomized control trial. Patients randomized to the treatment group will receive 2g of vancomycin applied as a powder or paste to the wound site and/or bone flap. Subjects in the control group will receive the current standard of care without topical vancomycin. All subjects will undergo swabbing of the anterior nares and the surgical site prior to surgery, once 10-14 days following the operation and 90 days following the operation. The primary outcome measure will be surgical site infection, assessed daily throughout the hospital stay, at the first follow-up visit, and by telephone at 14-30 days and 90 days (+/- 7 days). Secondary outcomes will include length of hospital stay, length of intensive care stay, rate of reoperation and patient mortality. In addition, systemic vancomycin levels will be assessed at 6 hours and 20 hours postoperatively in each patient. Patients who have an external ventricular drain in place will have vancomycin levels assessed daily. In patients who have cranial drains placed, vancomycin concentrations will be analyzed from daily in wound drainage. Skin and nasal flora will be analyzed to assess the impact of topical vancomycin on the patient microbiome. Although there has been a decrease in the incidence of infections following craniotomy secondary to prophylactic intravenous antibiotics, proper sterile techniques, and other interventions, SSIs continue to significantly impact morbidity, mortality, and cost burden. Although never studied in neurosurgical procedures other than instrumented spine, the application of topical vancomycin to the surgical site prior to wound closure has demonstrated a reduction in SSIs in spine, cardiac and ophthalmologic procedures. The benefits of using prophylactic vancomycin topically, as opposed to intravenously, include reduced systemic levels of the drug, and therefore, a decreased probability of adverse events related to the drug, such as inducing resistance among the native flora. The investigators propose a single-blinded randomized control trial to evaluate the effectiveness of topical vancomycin in reducing SSIs rates following neurosurgical procedures. |
E. SANDER CONNOLLY; | 2025-10-29 |
| 196 | A Randomized Double-Blind, Placebo-Controlled, Crossover to Open Label, Phase 2 Study of Aerosolized Amikacin and Fosfomycin Delivered Via The Investigational EFlow® AFIS Inline System in Mechanically Ventilated Patients With Gram-negative And/or Gram-positive Bacterial Colonization Related Papers Related Patents Related Grants Related Experts Highlight: To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin Fosfomycin Inhalation System (AFIS) versus aerosolized placebo in mechanically ventilated patients with Gram-negative and / or Gram-positive bacterial colonization. |
CARDEAS PHARMA | 2016-01-01 |
| 197 | A Randomized Comparison Study of Minimally Invasive Loop Drainage Versus Standard Incision and Drainage for Skin Abscesses in Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to compare abscess drainage utilizing the vessel loop technique in children to the standard incision and drainage technique with the endpoint to determine if rates of treatment failure are non-inferior. |
LOGAN R RENCHER; | 2016-04-01 |
| 198 | Effectiveness of Screening and Decolonization of S. Aureus in Surgery Outpatients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Staphylococcus aureus (SA) healthcare-associated infections (HAI) cause significant morbidity and mortality. SA causes 15% of all HAI and 30% of surgical site infections (SSIs). Each year over 40 million Americans undergo operations, 1-10% of whom will acquire SSIs. Such infections double the length of hospitalization and risk of dying, … |
SUSAN E KLINE; | 2016-08-01 |
| 199 | Comparison Between Two Different Antibiotic Regimens for The Placement of Dental Implants: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In order to prevent infections and complications, it has been initially established with the dental implant placement protocol that pre- and post-operative antibiotics should be prescribed to the patient receiving dental implants. There have been many antibiotic regimens used in the attempt to minimize the risks of infections and consequently, increasing the survival rate of dental implants placement procedures. However, … |
ROBERT DURAND; | 2017-05-01 |
| 200 | Knowledge and Perception of Resistance to Antimicrobials in French Healthcare Facilities PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The objectives of this survey are to determine the level of antimicrobial resistance knowledge and perception of health care workers (HCW) in France, to measure the impact of health care facilities (HCF) and to identify the drivers and barriers to change. To achieve this goal, a cross-sectional survey on one day with a self-administered questionnaire and semi-structured interviews with HCWs is proposed. This study will be planned in 60 different HCFs randomly selected and expected to include of 2,100 to 10,000 respondents. |
JEAN CHRISTOPHE LUCET; | 2016-02-01 |