Clinical Digest: Recent Clinical Trials on Overweight (Obesity) (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Overweight (Obesity). These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Overweight (Obesity) (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Real-world Effectiveness and Dosing Patterns of Tirzepatide: A Multicentre Retrospective Observational Study in The Netherlands PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Tirzepatide is one of the new medications for the treatment of obesity. In clinical research people treated with Tirzepatide have weight loss up to 21%. But there is only a little bit of research showing the effect of Tirzepatide in clinical practice. In this retrospective observational study the investigators will evaluate the effectiveness of tirzepatide in routine clinical practice among adults with obesity in the Netherlands.The main questions it aims to answer are: * How much weight do patients lose after six months of treatment with tirzepatide combined with lifestyle coaching? * How is the medication dosed in daily practice? Researchers will use data from electronic health records of patients in multiple outpatient locations of the Dutch Obesity Clinic (NOK, Nederlandse Obesitas Kliniek). |
MARIA HOPMAN; | 2026-03-31 |
| 2 | MORPHOMETRIC, FUNCTIONAL AND LIFESTYLE PREDICTORS OF TESTOSTERONE DECLINE IN MIDDLE-AGED MEN: A POPULATION-BASED CROSS-SECTIONAL STUDY PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Age-related decline in testosterone levels in men is associated with multiple metabolic, functional and psychosocial consequences. Early identification of modifiable factors associated with decreased testosterone levels may contribute to improved prevention of androgen deficiency and related health conditions. This population-based observational cross-sectional study aims to investigate morphometric, functional and lifestyle factors associated with decreased total testosterone levels in middle-aged men. Approximately 650-800 men aged 35-55 years residing in the Andijan region of Uzbekistan will be recruited. Participants will undergo comprehensive assessment including anthropometric measurements, functional performance tests, … |
ABDUKHALIM KH. ABDURAKHIMOV; | 2026-03-20 |
| 3 | Enhancing Weight Loss in A Digital Intervention Among Adults With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of the Reset trial is to learn about the optimal combination of dietary behavior strategies in a fully digital weight loss intervention. The intervention is designed for adults with overweight or obesity. The investigators will examine the impact on weight loss of four dietary strategies: 1) limiting Red Zone Foods (i.e., foods that are high in calories and low in nutrition), 2) limiting eating windows, 3) increasing protein intake, and 4) increasing fiber intake. Each of these strategies will include goal setting, daily self-monitoring, and tailored feedback. The investigators will recruit 208 participants. Broadly, … |
MICHELE PATEL; | 2026-03-03 |
| 4 | A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate The Efficacy and Safety of IBI362 in Participants With Mild to Moderate Hypertension Complicated By Overweight/Obesity Who Have Not Received Antihypertensive Drug Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Abstract: Change from baseline in msSBP at trough (end-of-dosing interval) at Week 16 Change from baseline in Mean Sitting Systolic Arterial Pressure(msSBP) at Week 24. Percent change from … |
INNOVENT BIOLOGICS SUZHOU | 2026-03-13 |
| 5 | A Randomized, Double-blind, Placebo-controlled, Parallel Clinical Trial to Investigate The Safety and Efficacy of MB-1 on Metabolic Health in Overweight and Obese Adults PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to investigate the safety and efficacy of MB-1 on metabolic health in overweight and obese adults. The main question it aims to answer is: What is the difference in change in body weight and body mass index (BMI) from baseline at Day 84 between MB-1 and placebo? Participants will be provided MB-1 or placebo and be assessed for anthropometric measurements, blood pressure, heart rate, and asked to complete appetite and satiety questionnaires and undergo a DEXA scan. |
DAVID CROWLEY; | 2026-01-26 |
| 6 | Longitudinal Evaluation of Gut Microbiota and Fecal Metabolome Following Roux-en-Y Gastric Bypass: Clinical Implications and Identification of Predictive Biomarkers PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn how bariatric surgery affects gut bacteria and gut-related metabolic products over time in adults with obesity. The study includes adults aged 18 to 65 years who are undergoing Roux-en-Y gastric bypass (RYGB) surgery, … |
DOMENICA MALLARDI; | 2026-02-05 |
| 7 | Optimizing Adaptive Intensive Behavioral Therapy for Obesity During The Transition to Older Adulthood: A Sequential Multiple Assignment Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To test adaptive intensive behavioral therapy strategies comprising dietary patterns with varying amounts of protein and including supplemental protein or resistance exercise training for promoting weight loss and attenuating lean mass loss in adults aged 50-75 with obesity. |
DREW SAYER; | 2026-03-03 |
| 8 | Evaluation of The Acceptability and Clinical Effectiveness of Augmenting Comprehensive Primary Care-Based Obesity Management With The Nutu™ Digital Health Platform PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the acceptability and clinical effectiveness of integrating the Nutu™ digital health platform into a comprehensive primary care-based behavioral obesity treatment program using a Zelen randomized controlled trial design. |
DREW SAYER; | 2026-02-13 |
| 9 | A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to determine the efficacy of oral KAI-7535 once daily compared with placebo on percent change in body weight in participants living with obesity or overweight, with at least 1 weight-related comorbidity, without diabetes mellitus. Efficacy in participants with type 2 diabetes mellitus will be evaluated. Safety and tolerability and other weight-related outcomes will be evaluated in both types of participants. |
KAILERA | 2026-03-27 |
| 10 | A Phase II Multi-institutional Randomized Trial Evaluating The Impact of GLP-1 Receptor Agonists in Combination With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to see if adding a weight loss medication (GLP-1 receptor drug) to patients with an increased BMI receiving treatment for rectal cancer prior to surgery (total neoadjuvant chemoradiotherapy) improves cancer outcomes. The main questions it aims to answer is 1. Does the drug increase weight loss in rectal cancer patients with a high BMI 2. Does the drug improve response rates to chemotherapy and radiotherapy 3. Does the drug improve survival outcomes and if cancer returns Researchers will compare this drug in one group against a group of patients receiving preoperative total neoadjuvant chemoradiotherapy without the drug Patients will be required to 1\) take the GLP-1 receptor agonist drug during TNT or just having TNT alone as per standard hospital protocols Body weight will be measured at three predefined time points: 1. Baseline: Prior to initiation of semaglutide or TNT 2. Pre-TNT: Start of TNT (for the intervention arm, this is 4 weeks after semaglutide initiation) 3. Post-TNT: Within 7 days following completion of TNT and prior to definitive surgery Patients will complete their treatment and go on to have surgery as per standard methods for treating rectal cancer |
BEN CREAVIN; | 2026-01-02 |
| 11 | Optimizing Glycemic Control in Metabolic Surgery With Continuous Glucose Monitoring PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: We will recruit 20 severely obese participants at Metamor Institute. Participants with obesity who are eligible for MBS will be randomized to either CGM group or self-monitoring of blood glucose (SMBG) group before the surgery based on a 1:1 ratio. All participants live in Baton Rouge, Louisiana. The surgeon in Metamor will introduce our study to the patients. If the patients are interested, the evaluation process includes verifying basic personal information, assessing health status and medical history, and evaluating specific eligibility criteria relevant to the study. The study coordinator will be discussing informed consent, ensuring participants understand the study’s purpose, … |
YUN SHEN; | 2026-03-13 |
| 12 | GLP-1 Receptor Agonist-Induced Loss and Impairment of Muscle Mass – Evaluation of Response PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide. By doing so, we hope to gain a clearer understanding of how semaglutide affects muscle health and function. Our goal is to ensure the medication supports long-term well-being, particularly for people who may be at higher risk of muscle loss. This study involves (3) in-person study visits. At each visit, … |
UNIVERSITY OF ALBERTA | 2026-03-13 |
| 13 | Impact of Foot Reflexology on Nausea After Obesity Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity is a major public health issue. The Obépi epidemiological survey, the results of which were published in 2020, shows a steady increase in obesity among the French population. Currently, more than 23 million French people are overweight or obese, and more than 8 million French people are obese. The most effective treatment currently available is surgery. These procedures are governed by specific recommendations. Between 50,000 and 60,000 procedures are performed in France each year. Three procedures are authorised: gastric banding, sleeve gastrectomy and gastric bypass. Hallyday \& al report 65% of patients experiencing nausea/vomiting after bariatric surgery. In 2019, … |
EMERIC ABET; | 2026-04-02 |
| 14 | A Phase I, First-in-Human, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IBIO-600 in Overweight or Obese Adult Participants (IBIO-600-CT001) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn which dose of study drug IBIO-600 has the right balance of safety, tolerability and impact on body composition in overweight and obese adult participants. |
IBIO | 2026-03-23 |
| 15 | CHOICE to AVOID or RESIST: Evaluating Participants’ Choice of Self-regulatory Strategy on Weight Management Outcomes: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This trials will formally test whether participants’ active choice of self-regulatory strategies (AVOID or RESIST) leads to greater adherence to weight management strategies by comparing the CHOICE arms to the randomized arms of the parent intervention, AVOID/RESIST (IRB STUDY00001652: AVOID-RESIST). |
SARAH SALVY; | 2026-02-17 |
| 16 | Health Promotion With Targeted Exercise Intervention for Decreasing Fall Risk and Inactivity in Aging Veterans With Obesity and Signs of Sarcopenia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Falls are a major health risk for older Veterans, especially those with both obesity and low muscle mass or strength (sarcopenia), which together increase the chances of falling and losing independence. Many older Veterans have difficulty staying active and often lack information about how to safely exercise. While current guidelines focus mostly on weight loss, losing weight alone can weaken muscles and bones, … |
JULIE S REKANT; | 2025-10-03 |
| 17 | A Randomized, Window of Opportunity Trial of Tirzepatide in Women With Obesity and A Diagnosis of Endometrial Intra-epithelial Neoplasia (EIN) or Grade 1 Endometrial Cancer PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to determine the anti-proliferative effect of tirzepatide on the endometrium of patients with endometrial intra-epithelial neoplasia (EIN) and Grade 1 endometrial cancer (EC), by comparing archival endometrial biopsy samples of patients randomized to tirzepatide versus SOC (no tirzepatide) to their post-intervention hysterectomy specimens. It was hypothesized that tirzepatide may help fight tumors in two ways: indirectly, by improving the body’s overall metabolic health, and directly, by acting on abnormal cells in the uterus, … |
VICTORIA BAE-JUMP; | 2026-01-16 |
| 18 | Effect of The Thrive AI Health App on Lifestyle Behaviors and Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goals of this randomized trial is to learn: 1. If the Thrive AI Health app will help adults improve their everyday habits (diet, exercise, and sleep). 2. How often participants will use the Thrive AI Health app to which they will have free access The Thrive AI Health app uses artificial intelligence (AI) to give personalized advice. It is designed to help people eat better, exercise more, manage stress, and sleep well. Researchers will compare changes in diet, … |
MELINDA IRWIN; | 2026-03-30 |
| 19 | Effect of A Progressive Resistance Exercise Program on Muscle Mass and Physical Function During A Tirzepatide Induced Weight Loss in Overweight and Obese Females: A Randomised Parallel Group Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the effect that a structured, progressive resistance exercise program may have on maintaining the muscle mass and physical function of overweight/ obese females whilst they experience a tirzepatide (GLP-1/GIP receptor agonist) induced weight loss. Overweight and obese females aged 25-50 will be recruited for the study, they will require a BMI of \>30 or \>27 with one obesity related comorbidity (excluding diabetes). They will be screened, … |
FRANCIS STEPHENS; | 2026-03-27 |
| 20 | The ‘Power of Pork Protein’ (From Diverse Pork Products) to Promote Health and Well-being During GLP-1 Medication Use in Middle-aged Women (With Overweight/Obesity) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Middle-aged women with (overweight/)obesity who will begin or have begun GLP-1 medication use will be recruited to complete a 12-week diet intervention study. For 12-weeks, participants will continue to take their GLP-1 medication and may be provided with protein-rich foods to consume every day. Body composition, eating behavior, health, and well-being will be measured before and after the study. |
HEATHER LEIDY; | 2026-03-18 |
| 21 | A Pilot Feasibility Study of Digitally Delivered Modules Focused on Preventing The Development of Obesity During The First Year of Life Within An Existing Statewide Home Visitation Program PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine feasibility and acceptability of a digitally-based obesity prevention intervention for mothers of infants participating in a home visitation program. The main questions it aims to answer are: * What impact does the digitally based obesity prevention intervention for parents have on children’s weight? * What impact does the digitally based obesity prevention intervention have on mothers’ feeding practices, child sleep, … |
AMY MOBLEY; | 2026-03-04 |
| 22 | The Importance of Insulin Action in The Brain for The Immune System During Physical Activity-Overweight Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to clarify the interaction of central insulin action and physical activity with the immune system. Therefore, participants will undergo bicycle spiroergometer tests. This approach will be compared between days with insulin delivery to the brain as nasal spray and days with placebo spray. In another trial (NCT06552130) lean participants already have been tested. Significant effects on circulating cytokines could be identified. In this amendment, overweight persons in which brain insulin resistance is expected will be tested. |
MARTIN HENI; | 2026-03-16 |
| 23 | Setmelanotide to Treat Obesity in A Patient With Pseudohypoparathyroidism Type 1a (PHP1a) Related Papers Related Patents Related Grants Related Experts Highlight: The investigators plan to test the efficacy and safey of 6-months of open-label setmelanotide to treat obesity in a single patient with pseudohypoparathyroidism type 1a due to a GNAS mutation. |
LINDSAY FOURMAN; | 2026-04-01 |
| 24 | A Phase 3, Randomized, Double-blind, Double-dummy, Parallel-group, Active Drug and Placebo-controlled, Safety, Efficacy and Superiority of Sibutramine IR/Topiramate XR in Overweight Adults With Comorbidities/Obesity Related Papers Related Patents Related Grants Related Experts Highlight: A phase 3, multicenter, randomized, double-blind, double-dummy, parallel-group, active-drug- and placebo-controlled clinical trial to assess the safety, efficacy and superiority of the new fixed-dose combination sibutramine IR/topyramat XR in weight reduction in overweight adults with comorbidity(ies) or obesity |
EUROFARMA LABORATORIOS S A | 2025-12-18 |
| 25 | A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate The Efficacy and Safety of Once-Weekly RO7795068 Administered to Participants With Obesity or Overweight Without Type 2 Diabetes PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the efficacy and safety of RO7795068, a dual glucagon like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with placebo for weight management in participants without Type 2 diabetes mellitus (T2DM) who have obesity or overweight with at least one weight-related comorbidity. |
HOFFMANN LA ROCHE | 2026-03-16 |
| 26 | A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate The Efficacy and Safety of Once-Weekly RO7795068 Administered to Participants With Obesity or Overweight and Type 2 Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the efficacy and safety of RO7795068, a dual glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with placebo for weight management in participants with obesity or overweight and Type 2 diabetes mellitus (T2DM). |
HOFFMANN LA ROCHE | 2026-03-17 |
| 27 | Reducing Obesity and Risk for Type 2 Diabetes in Latinas Using A Novel Behavioral Strategy Addressing Appetitive Traits PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Adapt the Regulation of Cues (ROC) treatment program for Latinas to see if it can treat prediabetes and prevent developing of Type 2 Diabetes and reduce weight. |
DAWN EICHEN; | 2026-03-17 |
| 28 | An Investigator- and Participant-Blind, Randomized, Placebo-Controlled, Parallel-Group, Phase I Study Evaluating The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an investigator- and participant-blind, randomized, placebo-controlled, parallel-group, Phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple doses of orally administered RO7795081 in otherwise healthy Chinese adult participants with obesity or overweight. |
HOFFMANN LA ROCHE | 2026-03-30 |
| 29 | A PHASE 1, OPEN-LABEL, MULTIPLE DOSE STUDY TO INVESTIGATE THE IMPACT OF PF 08653944 ON GASTRIC EMPTYING IN ADULT PARTICIPANTS WITH OVERWEIGHT OR OBESITY PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study looks at how a study medicine called PF-08653944 affects how quickly the stomach empties food after eating. It is being done in adults who are overweight or have obesity. Participants will receive the study medicine for a short period, and doctors will measure how the medicine moves through the stomach and monitor safety. The goal is to better understand how this medicine works in the body and to check for any side effects. The information from this study may help researchers plan future studies of this medicine. |
PFIZER | 2026-04-02 |
| 30 | The Effect of GLP-1 Receptor Agonist-based Treatment on Body Composition and Muscle Mass in Adults With Obesity: The Role of Dietary Protein Consumption in Muscle Mass Maintenance PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates how weight-loss medications, specifically GLP-1 receptor agonists, affect body composition, with a special focus on preserving muscle mass in adults with obesity. While these medications are highly effective for weight loss, they can sometimes lead to an unwanted loss of valuable muscle mass (a condition that can lead to sarcopenia). To explore how to prevent this, researchers are conducting a 3- … |
CHRISTOPHER PAPANDREOU; | 2026-04-02 |
| 31 | Effect of Once-weekly Subcutaneous Administration of NNC0487-0111 on Energy Intake, Appetite and Postprandial Metabolism in Participants With Obesity – A Randomised, Placebo-controlled, Double Blinded Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this clinical study is to look at if/how much NNC0487-0111 affects food intake, appetite and metabolism in participants with obesity when compared to placebo. There are 2 study treatments in this study. Participants will inject the study treatment under the skin of your stomach once a week. Participants will get either NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants will get is decided by chance. |
NOVO NORDISK | 2026-04-02 |
| 32 | The Laparoscopic Transit Bipartition Without Gastrectomy With Use Metalic Anastomosis Clip (MAC) for Treating Type 2 Diabetes Mellitus and Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates a new surgical device – the Metallic Anastomotic Clip (MAC) – for performing a laparoscopic bypass gastroenteroanastomosis with entero-enteric anastomosis (transit bipartition / dual-path procedure) in patients with type 2 diabetes mellitus (T2DM) who have overweight or Class I obesity (BMI 25-34.9 kg/m²). Currently, most bariatric and metabolic surgery procedures are only approved for patients with a BMI above 35 kg/m². However, … |
ORAL OSPANOV; | 2026-03-27 |
| 33 | Effects of Ramadan Diurnal Fasting Combined With A Structed Aerobic Exercise on Body Composition and Cardiometabolic Health in Adults With Overweight and Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this interventional study is to examine the effects of Ramadan diurnal fasting alone and in combination with moderate-intensity aerobic exercise on cardiometabolic health in adults with overweight and obesity. The main questions it aims to answer are: 1. Does Ramadan diurnal fasting lead to changes in body composition and cardiometabolic health outcomes? 2. Does adding moderate-intensity aerobic exercise during Ramadan fasting result in greater improvements in cardiometabolic health compared with fasting alone? Participants will be randomly assigned to one of two groups: Ramadan diurnal fasting only or Ramadan diurnal fasting combined with a supervised moderate-intensity aerobic exercise program. Cardiometabolic, metabolic, and behavioral outcomes will be assessed before Ramadan and during the last week of Ramadan. |
ABDULLAH ALWALEEDI; | 2026-03-13 |
| 34 | Nantes Bariatric Surgery Cohort PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese individuals. The NBC study aims to investigate : 1. Whether bariatric surgery is associated with changes in biological age 2. If bariatric surgery alters adipocyte dysfunction, the microbiota and biological rhythms 3. Whether changes in adipocyte dysfunction, microbiota and biological rhythms are linked to changes in biological age. To achieve this, establishing a biocollection before, … |
DAVID JACOBI; | 2026-04-03 |
| 35 | Examining Valence-based Effects in Self-monitoring Feedback Messages, in The Development of A Novel Semi-automated Self-monitoring Feedback System for Obesity Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to learn how to identify the most effective ways to provide weekly feedback on participants’ progress toward intervention goals during a weight loss program. |
REBECCA A. KRUKOWSKI; | 2026-03-31 |
| 36 | Effectiveness and Safety of Inactivated Akkermansia Muciniphila Akk11 (34B) on Weight and Energy Metabolism in Overweight and Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the impact of pasteurized Akkermansia muciniphila Akk11 capsules versus placebo on body composition (including body weight, BMI, body fat percentage, waist-to-hip ratio, wrist circumference, visceral fat area, and basal metabolic rate) and serum lipid parameters (TC, LDL-C, HDL-C, and TG) in overweight and obese adults. |
WECARE PROBIOTICS | 2026-04-02 |
| 37 | Effects of A Fiber- and Polyphenol-rich Diet on Brain Inflammatory Processes in Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: People living with obesity have a higher risk of late-life cognitive decline and developing dementia. In women, the risk of cognitive decline may further raise during the menopausal transition, a period of substantial hormonal and metabolic changes. Recent studies suggest that a healthy diet could help to prevent neurocognitive disorders by reducing inflammatory processes in the body and brain. Emerging evidence further indicates that the gut-brain axis and the intestinal microbiome play a crucial role in mediating this effect, through metabolic, immune, … |
VERONICA WITTE; | 2026-03-30 |
| 38 | A Phase 2, Double-Blind, Placebo-Controlled Study to Assess The Pharmacokinetics, Safety, Tolerability, and Efficacy of Olatorepatide, A GLP-1/GIP Receptor Agonist, in Participants Living With Overweight or Obesity in The US PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will test olatorepatide (study drug) to determine how safe and effective this drug is and how easily your body can accept this drug without causing side effects, … |
REGENERON PHARMACEUTICALS | 2026-03-27 |
| 39 | Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This proposal evaluates the implementation of a novel, non-interruptive, electronic health record alert for metabolic dysfunction-associated steatotic liver disease (MASLD) fibrosis risk assessment in primary care patients with MASLD using a stepped wedge, cluster randomized design. This work will generate generalizable data to dramatically enhance MASLD management in primary care. |
ANDREW SCHREINER; | 2026-03-31 |
| 40 | A Smart Wearable Devices-based Comprehensive Intervention Through A Cluster Randomized Controlled Trial to Improve Cardiovascular Health in Overweight/Obese Individuals With Cardiometabolic Preconditions PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to employ a cluster randomized controlled trial to evaluate the effectiveness of an mHealth-Based Multi-faceted Cardiovascular Health Intervention Model among Overweight/Obese Individuals with Cardiometabolic Preconditions, thereby providing theoretical foundations and practical guidance for the prevention and management of this population. |
YUE QI; | 2026-01-28 |
| 41 | Impact of Whole-body Vibration Training (WBVT) on The Elderly With Combined Bilateral Knee Osteoarthritis (KOA) and Sarcopenic Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will aim to evaluate the effects of whole-body vibration training (WBVT) on body composition, muscle strength (hand grip strength), and physical performance \[gait speed (GS), 5-time chair stand test (5CST), and short physical performance battery (SPPB), pain intensity, triglycerides in older people with knee OA and sarcopenic obesity in a group of Men compared to group of females. |
MARIAM ABDEL RAHMAN; | 2026-03-18 |
| 42 | Improving Cervical Cancer Prevention Among Women Living With Chronic Conditions. Aim 3: Assess The Feasibility and Acceptability of The PINPOINT Intervention PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Our overarching goal is to adapt and test the PINPOINT intervention -PatIent Navigation for the Prevention of CervIcal CaNcer inTervention. We will test the PINPOINT intervention among patients with high-risk profiles for cervical cancer who do not meet the recommended screening for cervical cancer. |
UNIVERSITY OF FLORIDA | 2026-01-20 |
| 43 | A Randomized Controlled Trial of Food Is Medicine Approaches for Obesity Treatment in Adults With Food Insecurity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if increased access to healthy foods, combined with behavioral weight loss (BWL) interventions, results in greater weight loss for adults with obesity and food insecurity. It will also learn about changes in health-quality of life and dietary quality. The main questions it aims to answer are: * Does BWL, combined with either home-delivered, medically-tailored (HOME) groceries or grocery vouchers (VOUCHER), … |
ARIANA CHAO; | 2026-03-16 |
| 44 | A Phase 2a, Randomized, Double-blind, Placebo-controlled Trial to Evaluate The Efficacy, Safety, and Tolerability of ECC4703 As An Adjunct to Semaglutide in Adults With Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this trial is to evaluate the effect of oral ECC4703 on body weight reduction and in a sub-study on liver fat content as assessed by change in magnetic resonance imaging proton density fat fraction (MRI-PDFF) at Week 20. |
ECCOGENE | 2026-04-01 |
| 45 | E-IMPACT: Evaluating An EHealth and Healthcare Professional Support Program to Promote Physical Activity During Pregnancy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This will be a proof-of-concept randomised control trial (RCT) study, where 100 pregnant women will be recruited in the first trimester of pregnancy and followed-up until delivery. It aims to test these following hypotheses: 1. pregnancy is a window of opportunity to implement good lifestyle habits of physical activity and exercise as pregnant women are in regular contact with health professionals and are likely motivated and be more confident to carry out these activities according to the guidelines 2. this integrated programme will effective in a healthcare setting, … |
ELAINE QUAH; | 2026-03-12 |
| 46 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 3 Study to Evaluate The Efficacy and Safety of Zovaglutide in Adults With Overweight or Obesity PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study will evaluate the percentage change in body weight from baseline and proportion of subjects achieving ≥ 5% weight loss from baseline after 52 weeks of treatment with Zovaglutide in subjects with overweight/obesity. |
LINONG JI; | 2025-12-23 |
| 47 | The Effect of The Use of A PHP-MySQL Database-Based Follow-Up System and Nursing Education on Quality of Life in Patients Undergoing Bariatric Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled experimental study aims to evaluate the effect of a PHP-MySQL database-based digital follow-up system combined with structured nursing education on quality of life, body mass index (BMI), and exercise habits in patients undergoing bariatric surgery. Although bariatric surgery is an effective treatment for morbid obesity, long-term success depends largely on adherence to lifestyle modifications, … |
SEDA AKKAYA; | 2026-03-09 |
| 48 | Phase 2b Randomized, Double-blind, Placebo-controlled Trial to Evaluate The Efficacy, Safety and Tolerability of Maridebart Cafraglutide in Adult Participants Living With Elevated Liver Fat and Obesity or Overweight PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this trial will be to determine whether maridebart cafraglutide is superior to placebo on reduction in liver fat content and body weight in participants living with obesity or overweight and elevated liver fat content, when administered in conjunction with reduced-calorie diet and increased physical activity. |
AMGEN | 2026-04-02 |
| 49 | Bioequivalence of Survodutide (BI 456906) When Administered Via Pre-filled Syringe (Formulation A) and Pre Filled Pen (Formulation B2) in Male and Female Trial Participants Who Are Healthy or Otherwise Healthy With Overweight/Obesity (an Open-label, Randomised, Single-dose, Two-period, Two-sequence Crossover Trial) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to find out whether different formulations of survodutide given by different delivery methods is taken up in the body in a similar way. Participants visit the study site regularly. During study visits, the doctors collect information about participants’ health. To assess the study endpoints, participants regularly have blood samples taken. |
BOEHRINGER INGELHEIM | 2026-03-05 |
| 50 | Testing An Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity and post-traumatic stress disorder (PTSD) are common among Veterans. PTSD increases risk for obesity, impacting functioning, health, quality of life, and premature mortality. Use of proven treatments for PTSD and obesity in VA is low. Furthermore, Veterans with PTSD lose less weight than those without PTSD in VA’s national weight management program. Based on pilot work, an integrated treatment that combines PTSD and weight management care-using behavioral and pharmacologic approaches-may improve weight and PTSD. Whether it improves these outcomes more than standard VA care is unknown, … |
KATHERINE D HOERSTER; | 2026-03-18 |
| 51 | A Phase 1/2, Randomized, Double-blind, Placebo-controlled, Study of The Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of ALN-2232 As Monotherapy and Co-initiated With Tirzepatide in Adult Participants With Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to: * evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses of ALN-2232 in patients with obesity * evaluate the safety, tolerability, efficacy, PK, and PD of multiple doses of ALN-2232 in patients with obesity * evaluate the safety, tolerability, efficacy, PK, and PD of multiple doses of ALN-2232 co-initiated with tirzepatide in patients with obesity |
ALNYLAM PHARMACEUTICALS | 2026-03-11 |
| 52 | A Phase I Clinical Study to Evaluate The Safety, Tolerability and Pharmacokinetic (PK) of Single-dose Administration of Semaglutide Nasal Spray (WL1006) in Adult Overweight or Obese Participants PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The specific aim of this study is to examine the Safety, Tolerability and Pharmacokinetic of Semaglutide Nasal Spray compared with placebo and positive control in Adult Overweight or Obese Participants. |
SHANGHAI WORLD LEADER PHARMACEUTICAL | 2026-03-12 |
| 53 | Peau O Le Vasa: Accelerating The Currents of Health Advances for Pasifika People PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, the investigators are testing the effectiveness and implementation of the Community Health Workers (CHW)-delivered PILI Pasifika Program (PPP) Standard Facilitation or Enhanced Facilitation across 3 regions, the U.S. Affiliated Pacific Islands (USAPI), the continental U.S., and Hawai’i, among 600 Native Hawaiian and Pacific Islander (NHPI) participants in two settings, (clinical and non-clinical) over a 3-year period. The PPP is a 3-month lifestyle intervention that includes a Social Determinants of Health (SDOH) component and was NHPI-adapted from the Diabetes Prevention Program’s Lifestyle Program, renamed to the PILI Lifestyle Program (PLP), which demonstrated effectiveness in improving weight, blood pressure, … |
JOSEPH K KAHOLOKULA; | 2026-02-06 |
| 54 | A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity Who Do Not Have Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to determine the effects of KAI-9531 administered by subcutaneous (SC) injection once weekly compared to placebo on percent change in body weight. |
KAILERA | 2026-03-09 |
| 55 | DECODE – Haemodynamic Effects Of Semaglutide and Tirzepatide – A Series of Pilot Studies PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: What is the research question? Semaglutide and tirzepatide cause weight loss and blood pressure reduction. However, weight loss only partially explains the blood pressure reduction. Based on previous studies, there might be direct effects in the cardiovascular system. In forearm blood flow studies, semaglutide and tirzepatide will be infused into the brachial artery to investigate their effects on the function of blood vessels. In systemic studies, … |
JOSEPH CHERIYAN; | 2026-03-19 |
| 56 | Effectiveness and Safety of Tirzepatide (t.g.) in Patients Treated at The Obesity Unit of The Department of Endocrinology of The Hospital De Clínicas, Faculty of Medical Sciences, UNA: Phase 4 Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 4 observational study evaluating the safety and effectiveness of tirzepatide (T.G.) manufactured by INDUFAR S.A. in 300 patients with obesity treated at the Obesity Unit of Hospital de Clínicas in Paraguay over 12 months. The primary objective is to assess the safety profile through monitoring adverse events. Secondary objectives include evaluating weight loss, metabolic parameters improvement, and treatment satisfaction in real-world clinical practice. |
ANA IRIS RAMIREZ; | 2026-03-25 |
| 57 | Primary-Care Strategies to Enhance Weight Management (PRISM) After Discontinuation of Anti-Obesity Medications PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial pilot is to determine the feasibility of an intervention to enhance weight management in patients who have stopped taking anti-obesity/weight management medications in primary care. The main questions it aims to answer are: * Can patients be recruited into the study efficiently? * Is the program acceptable to patients? * Can the study be conducted efficiently? The new program will be compared to usual care. Participants will be asked to 1) complete short surveys about their medication use while taking the weight management medication, 2) complete online visits using study-provided scales, … |
RUSH UNIVERSITY MEDICAL CENTER | 2025-12-17 |
| 58 | Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: EGO-Trial is the first multicenter study in France which aims to evaluate the efficacy of Endoscopic Sleeve Gastroplasty (ESG) in patients with obesity. This project fills a critical national gap by providing real-world, multicentric data from diverse French healthcare settings, offering insight into the safety, efficacy, and variability of ESG practices across institutions The project is expected to generate robust, multicentric clinical evidence on the safety and efficacy of ESG in patients with obesity within the French healthcare context. |
SILVANA PERRETTA; | 2026-03-04 |
| 59 | A Phase 1b, Randomized, Investigator- and Participant-Blinded, Placebo-Controlled Multiple-Dose Study to Evaluate The Pharmacodynamics, Safety, Tolerability, and Pharmacokinetics of Brenipatide in Healthy Participants With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of this study is to evaluate how different dose levels of brenipatide work and how safe they are in healthy people with overweight or obesity. The study will assess the effects of different doses given as subcutaneous (under the skin) injections. Participation in this study will last about 42 weeks. |
KATHLEEN DOISY; | 2026-03-17 |
| 60 | A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Study to Evaluate The Efficacy and Safety of VCT220 in Participants With Hypertension and Obesity or Overweight PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to explore the safety and efficacy of VCT220 for the treatment of hypertension in participants with obesity or overweight. |
VINCENTAGE PHARMA | 2026-01-22 |
| 61 | Real-world Canadian Retrospective Study Evaluating Longitudinal SEMAglutide Use on Cardio-Kidney-Metabolic Outcomes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to better understand the real-world effectiveness of semaglutide use on cardio-kidney-metabolic outcomes among adults with T2D and adults with obesity (without diabetes mellitus). This is a retrospective longitudinal analysis using the LMC Diabetes Registry. The primary outcome of the study is to evaluate the change in HbA1c between baseline to 3 years of follow-up among adults with T2D who initiated semaglutide compared to adults with T2D who initiated other AHAs, including sulfonylurea, dipeptidyl peptidase-4 inhibitors, and sodium-glucose cotransporter-2 inhibitors. |
LMC DIABETES & ENDOCRINOLOGY | 2026-02-20 |
| 62 | Nutritional Approach for The Transformation and Reduction of Chronic Disease Indicators in Middle-aged Adults at High Risk PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the effect of a multifactorial lifestyle intervention combining Mediterranean diet, energy reduction and physical activity on weight loss in middle-aged adults (men and women 30-50 years old) with metabolic syndrome. The main questions it aims to answer are: Is a multifactorial intervention based on Mediterranean diet, … |
LIDIA DAIMIEL RUIZ; | 2026-03-27 |
| 63 | IWAIST Trial: A Multicenter, Single-Blind, Randomized, Sham-Controlled Trial of Endoscopic Radial Compression Gastroplasty (ERCG) Plus Optimized Lifestyle Intervention for Weight Management in Chinese Adults With Overweight or Mild-to-Moderate Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity and overweight are rising in Chinese populations, where metabolic risks begin at lower BMI thresholds than in Western cohorts. Many individuals with overweight or mild-to-moderate obesity are ineligible or unwilling to undergo bariatric surgery due to invasiveness and risk. Endoscopic bariatric and metabolic therapies offer minimally invasive alternatives but vary in complexity, cost, and safety profiles. Investigators developed a sutureless endoscopic procedure, Endoscopic Radial Compression Gastroplasty (ERCG), … |
LIU YAN; | 2026-03-13 |
| 64 | A Phase 4, Open-Label, Single-Arm, 46-Week Study to Investigate The Safety and Efficacy With Tirzepatide in Adult Indian Participants With Either Type 2 Diabetes or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of this study is to measure the safety and efficacy of tirzepatide in adult participants in India who have type 2 diabetes or who have obesity or overweight without type 2 diabetes. Participation in the study will last about 46 weeks. |
KARTIKEYA PARMAR; | 2026-02-27 |
| 65 | Strategies for Improving The Detection of Dysglycemia in The Postpartum Period in Women With Gestational Diabetes: Electronic Reminders and New Diagnostic Criteria PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Gestational diabetes mellitus (GDM) is one of the most common clinical conditions in pregnancy, with an increasing incidence due to the rise in overweight women and the postponement of motherhood. It is associated with perinatal complications and an increased risk of developing prediabetes and type 2 diabetes after delivery. Therefore, it is recommended that a 75g oral glucose tolerance test (OGTT-75g) be performed between 6 and 12 weeks postpartum. Despite its relevance, … |
TATIANA ASSUNÇÃO ZACCARA; | 2026-03-24 |
| 66 | Safety and Effectiveness of Orbera365™ Intragastric Balloon System: A Multi-Center, Prospective, Standard of Care Registry PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, multi-center, standard of care registry offered to subjects in the EU only that have already agreed to receive the Orbera365™ Intragastric Balloon (IGB) System for weight loss. Subjects that agree to participate in the registry will have data reported associated with standard of care weight management visits during the time the device is implanted (in-dwell period), with an additional visit 30 days after the removal procedure. |
DANA CHARPENTIER; | 2026-03-12 |
| 67 | Holistic Approach to Cardiometabolic Health and Obesity: Incretin-based Therapies, Nutrition, and Active Lifestyle PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether combining a six-month structured lifestyle intervention (physical activity and nutrition) with incretin-based weight-loss medication improves preservation of muscle mass and physical function in adults living with obesity, compared with medication alone, and to assess the feasibility of a collaborative hospital-community care model. This one-year pilot study will recruit 120 adults aged 18-70 years with obesity (BMI ≥30 kg/m² or ≥27 kg/m² with at least one comorbidity) receiving routine obesity care at the Institut universitaire de cardiologie et de pneumologie de Québec – … |
ANDRÉANNE MICHAUD; | 2026-02-13 |
| 68 | Evaluation of App-only Users Compared With Wearable Band + App Users With Regard to Weight Management and Program Engagement on The BetterMe Platform PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial aims to evaluate the effectiveness of a mobile wellness application, both alone and in combination with a wearable fitness tracker, for supporting weight management, physical activity, and mental well-being. Adults with a body mass index (BMI) ≥25 will be randomized to one of three groups: (1) mobile wellness application + wearable tracker, (2) mobile wellness application only, or (3) control receiving standard health information. Participants will use the interventions over a 12-week period, and outcomes including weight change, activity levels, and self-reported mental health will be assessed. |
BETTERME | 2026-03-11 |
| 69 | COMPASS 65+ – Community-based Physical Activity Snacks for Healthy Aging in Overweight and Obese Aged Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will explore a new way for older adults to become more physically active. As people get older, it’s common to gain weight and lose muscle strength. This combination can make it harder to do daily activities, increase the risk of falls, and impact overall quality of life. While we know that regular exercise is very beneficial, many older adults find it difficult to stick to traditional exercise programs due to lack of time, motivation, or energy. This research project, called COMPASS 65+, will test an innovative approach called snack exercise. Instead of one long workout, … |
SUSANA MIGUEL; | 2025-12-17 |
| 70 | Exploring Tannin-Probiotic Interactions on Microbial Composition and Inflammatory Outcomes in Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to understand how gallotannin-rich (GT-rich) mangoes can reduce the inflammatory markers in obese individuals in vitro. The study will also seek to explore how gallotannins are metabolized in the gut microbiome. The main questions the research aims to answer are: * What is the impact of GT extract from mango and Lactiplantibacillus pentosus supplementation on inflammatory biomarkers in obese individuals? * Does the combination of GTs and L. pentosus exhibit synergistic effects in modulating specific microbial taxa associated with obesity and inflammation compared to either intervention alone? * Does genetic variation among individuals with obesity account for the ability to metabolize gallotannins? Researchers will compare the effects of GT extract from mango juice, a combination of GT-rich extract, and L. pentosus probiotic supplement on samples (stool) provided by obese individuals, to samples provided by a lean control group to see if gallotannins and gallotannins + probiotic supplementation reduce inflammation in obesity. Participants will * Be grouped into 4 treatment groups 1. Mango juice only 2. Mango + L. pentosus 3. L. pentosus only 4. Control (lean individuals) * Visit sample collection site one time during the study (week 1) |
JANET ANTWI; | 2026-04-01 |
| 71 | Feasibility and Acceptability of A Pediatric Referral to Summer Day Camps to Treat Obesity in Children From Low-Income Households PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Children from low-income households have a 25-30% higher prevalence of OWOB compared to their higher-income peers. The lack of feasible and effective treatments to address obesity in children with OWOB and from low-income household’s points to a real need for prioritization and urgency. The U.S. Preventive Services Task Force (USPSTF) notes several shortcomings with current behavioral interventions and clinical practice to treat children with OWOB. Current efforts lack the necessary intensity recommended by USPSTF (26-52 hours in a 6-month period); incorporate multi-component interventions that are not feasible to consistently deliver; do not consider barriers to services/programs, such as cost; … |
UNIVERSITY OF CENTRAL FLORIDA | 2026-03-11 |
| 72 | Effect of Electroacupuncture on Central Obesity and Fatty Liver in Postmenopausal Women: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to determine the effect of electroacupuncture on central obesity and fatty liver in postmenopausal women. |
MOHAMED ABDEL HAMID ELGAEDY; | 2026-02-27 |
| 73 | A Randomized, Double-Blind, Placebo-Controlled Multicenter Phase 2 Study to Evaluate The Safety, Efficacy and Tolerability of Ofirnoflast (HT-6184) and Semaglutide in Obese or Overweight Participants With Type 2 Diabetes Mellitus (T2DM) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the efficacy and safety of ofirnoflast in combination with semaglutide in comparison to semaglutide alone in obese participants with T2DM. |
HALIA THERAPEUTICS | 2026-02-11 |
| 74 | Lifestyle Intervention to Prevent Obesity and Eating Disorders in Transgender and Gender-Diverse Adolescents: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Transgender and gender-diverse adolescents are at increased risk for obesity, disordered eating behaviors, body dissatisfaction, and reduced quality of life due to minority stress and structural inequities. However, no structured lifestyle interventions specifically tailored to this population have been developed. This randomized controlled trial aims to evaluate the effectiveness of a 6-month interdisciplinary lifestyle intervention designed to prevent obesity and eating disorders in transgender and gender-diverse adolescents aged 10-14 years. Participants will be randomized (1:1) to either an intervention group receiving monthly group sessions (for adolescents and caregivers separately) and weekly supportive messages, … |
BRUNO GUALANO; | 2026-03-12 |
| 75 | Magnetic Compression Anastomosis in Side-to-Side Duodeno-ileostomy Versus Semaglutide in Adults With Obesity and Type 2 Diabetes (MAGvMED Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Compare use of the Magnet System in side-to-side duodeno-ileostomy (Surgery) with semaglutide (Medication). |
MICHEL GAGNER; | 2026-02-20 |
| 76 | Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a 28-week, single-arm, open-label phase II clinical trial evaluating the combination of Tirzepatide and remote, supervised, tailored resistance exercise training to achieve weight loss in adult survivors of childhood acute lymphoblastic leukemia (ALL) living with obesity or overweight with comorbidity. Primary Objective(s): • To evaluate the effectiveness for weight loss of the combined intervention using once weekly Tirzepatide plus remote, supervised, tailored resistance exercise (three sessions per week) in adult survivors of childhood ALL with obesity or overweight (BMI ≥27 kg/m2) with ≥1 weight-related comorbidity (hypertension, dyslipidemia, obstructive sleep apnea, … |
STEPHANIE B DIXON; | 2026-02-04 |
| 77 | Semaglutide Treatment for Alcohol Use Disorder After Metabolic and Bariatric Surgery: A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to evaluate the feasibility of treating Alcohol Use Disorder with Semaglutide after metabolic and bariatric surgery in adults with overweight or obesity. |
VALENTINA IVEZAJ; | 2026-02-04 |
| 78 | An RCT: Impact of Chia Seeds on Human Breast Milk Composition PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators’ over-arching hypothesis is that mechanical and compositional properties of chia seeds supplemented during lactation diminish obesity-induced intestinal inflammation and barrier dysfunction. The investigators hypothesize these changes will result in: 1) reduced maternal systemic inflammation (serum CRP and IL-6) and increased gut microbial diversity and richness, 2) reduced HM fat and inflammatory markers, metrics the research team have demonstrated differ in tandem with maternal metabolic health and 3) improved infant growth/body composition. To test these hypotheses, … |
DAVID A FIELDS; | 2026-01-15 |
| 79 | Efficacy of Inspiratory Muscle Trainer on Respiratory Functions Exercise Capacity and Pain Intensity in Adults With Obesity and Mechanical Low Back Pain. A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Obesity and mechanical low back pain (MLBP) are two major health problems negatively affecting the human body. Many studies have shown that obesity and MLBP are associated with negative effects on the respiratory system. There are many interventions to treat obesity and MLBP, such as aerobic exercise and diet programs. Moreover, the Inspiratory Muscle Trainer (IMT) significantly improved inspiratory muscle strength in patients with obesity. This study aims to investigate whether adding IMT to aerobic exercise will improve respiratory function, exercise capacity, … |
MAALI MOHAMMED ALQAHTANI; | 2026-01-06 |
| 80 | Effect of Non-invasive Vagal Nerve Stimulation on Selected Outcomes in Central Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Trans Cutanous Electric Nerve Stimulation of Auricular Vagus Nerve |
NESSREEN G AL-NAHAS; | 2026-03-03 |
| 81 | Emotion Regulation Intervention to Improve Neural Responsiveness and Health PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if an emotion regulation and self-monitoring intervention can help treat overweight and obesity in teens. The main question it aims to answer is: * Does emotion regulation and self-monitoring help reduce biases in teens with overweight and obesity? * Do changes in biases relate to changes in health functioning and health behavior? Researchers will compare the intervention to the provision of educational handouts about overweight and obesity to see if the intervention is more effective. Participants will: * Complete self-report questionnaires, an fMRI scan, … |
CAROLINE CUMMINGS; | 2026-02-17 |
| 82 | Bioequivalence of Two Survodutide (BI 456906) Formulations Via Subcutaneous Administration After Multiple Doses (an Open-label, Randomised, Multiple-dose, Crossover Trial) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this trial is to assess bioequivalence of two formulations of survodutide (formulation A and formulation B6) after multiple-dose treatment in male and female trial participants living with overweight or obesity. |
BOEHRINGER INGELHEIM | 2026-03-17 |
| 83 | A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy of Tradipitant on Nausea and Vomiting After GLP-1R Agonist Administration in Healthy Overweight or Obese Volunteers PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment arms. |
VANDA PHARMACEUTICALS | 2026-03-03 |
| 84 | EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY-BIASED ULTRA LONG-ACTING GLP-1RA, IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES: A PHASE 3, MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED TRIAL (VESPER-5) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this clinical study is to learn about the safety and effects of the study medicine to help adults with obesity or overweight and type 2 diabetes lose weight. Being overweight or obese means carrying too much body weight. Type 2 diabetes is a condition where there is too much sugar in the blood. The study medicine is given by a shot under the skin in the belly area. The participants will be trained to do this at home once every week. About 660 out of 1000 adults will also receive the study medicine and about 330 out of 1000 adults will receive placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. The investigators will compare the experiences of people receiving the study medicine to those of the people who do not. This will help us assess if the study medicine is safe and effective. People will take part in this study for about 21 months. During this time, they will have about 14 study visits at the site and 5 over the phone. |
PFIZER | 2026-03-30 |
| 85 | Pathways, Risk Factors, and MOleculeS to Prevent Early-onset Colorectal Tumors PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research study is an open-label Phase 1 Exploratory/Pilot clinical trial to measure the effects of the incretin mimetic, tirzepatide, on tissue, urine, blood, and microbiome biomarkers associated with colorectal cancer risk and to understand the feasibility of this precision prevention trial approach for a future larger study. |
ANDREW T. CHAN; | 2026-02-27 |
| 86 | Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a trial to find out how weight loss (achieved by the use of tirzepatide) or ixekizumab treatment affects the characteristics of skin, joint and fat tissues in patients with Psoriatic Arthritis, Psoriasis and obesity/overweight BMI \>=27. Participants will be allocated either Tirzepatide, Ixekizumab or both. Samples of joint tissue, fat and skin will be taken at the start of the study and week 12. Blood and urine samples will also be taken. The primary objective will be to assess the changes seen in the joint, … |
CARL GOODYEAR; | 2026-03-02 |
| 87 | A First Human Dose Study Investigating Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of Single and Multiple Ascending Doses of NNC6989-0001 in Healthy Participants With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is testing a new medicine, NNC6989-0001, to test it is safe and tolerable for healthy people living with overweight or obesity. NNC6989-0001 is still being tested in studies and is not yet available for prescription by doctors. In this study, participants will receive either NNC6989-0001 or a placebo; which treatment each participant receives will be decided by chance. |
NOVO NORDISK | 2026-02-27 |
| 88 | The Metabolic Effects of Oral Tributyrin Administration in Overweight/Obese Individuals PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this double-blinded randomized clinical cross-over trial is to investigate the metabolic and appetite regulating effects of oral tributyrin (a butyrate pro-drug) administration vs placebo. The main questions it aims to answer are: * Does tributyrin have glucose lowering properties in humans? * Does tributyrin reduce appetite in humans? A sample size calculation estimated a minimum of 10 participants. We expect to include 12 participants in this study. Tributyrin or placebo is ingested once or twice daily for 2×2 weeks, … |
UNIVERSITY OF AARHUS | 2026-03-16 |
| 89 | Biased G Protein-Coupled Receptor Kinase Signaling Via Β2-Adrenergic Receptors and Downstream Activation of Protein Synthesis-Regulating Kinases and Receptor Desensitization in Human Skeletal Muscle PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This longitudinal mechanistic physiological study examines biased β2-adrenergic receptor (β2-AR) signaling in human skeletal muscle, with emphasis on G protein-coupled receptor kinase (GRK)-mediated pathways. Participants will receive daily oral dosing of the GRK-selective long-acting β2-agonist ATR-258 for 8 weeks. Muscle biopsies and physiological measurements will quantify GRK-, cAMP/PKA-, and β-arrestin-related signaling, fiber-type specificity, and potential receptor desensitization with repeated stimulation. |
MORTEN HOSTRUP; | 2026-02-19 |
| 90 | The Fast In-Bed Tracking (FIT) System Lifestyle Intervention PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project will complete the final design and development steps to commercialize the Fast In-Bed Tracking (FIT) Platform, which is an e-Health and wellness Internet of Things (IoT) monitoring system that can be integrated into a user’s bed and provide person-centered, real-world outcomes to support health and wellness. The technical feasibility of FIT was proven over the past several years and has demonstrated the platform can support the treatment of several chronic conditions across different populations, including obesity, congestive heart failure, … |
JONATHAN PEARLMAN; | 2026-02-23 |
| 91 | Effects of Lower Body Positive Pressure Therapy Versus Alpha Lipoic Acid and Omega-3 Fatty Acids on Pain, Function, and Inflammation in Overweight Women With Knee Osteoarthritis: A Randomized Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Here is a \*\*concise, clear summary (\~250 words / well under 5000 characters)\*\* while preserving the key scientific points: \— Knee osteoarthritis (KOA) is highly prevalent among overweight women, affecting more than 30% of those with BMI ≥25 kg/m². Excess body weight increases knee joint loading by 4-6 times per additional kilogram, accelerating cartilage degeneration, subchondral bone changes, and synovial inflammation. These alterations result in chronic pain, stiffness, functional limitation, and reduced quality of life, with obesity-related metabolic inflammation further worsening disease progression. Standard physical therapy (PT) remains first-line treatment, yet provides only modest benefits, … |
EMAN SAID SAWAN; | 2026-02-10 |
| 92 | A Phase 2 Study of Once-Weekly LY3437943 Compared With Placebo in Participants Who Have Obesity or Are Overweight With Weight-Related Comorbidities PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Phase 2, multicenter, randomized, double-blind, placebo-controlled study evaluating once-weekly subcutaneous retatrutide (LY3437943) at multiple maintenance dose levels versus placebo in adults with obesity or overweight with weight-related comorbidities (without type 2 diabetes), alongside standardized diet and physical activity counseling. |
HUDSON BIOTECH | 2026-03-12 |
| 93 | Gut Microbiota, Diet-INDuced Obesity and Type 2 Diabetes in New Caledonia – MIND PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In recent years, the global rise in obesity and type 2 diabetes has become a major public health issue. In New Caledonia, 38% of the adult population has a body mass index ≥30. At the same time, the prevalence of type 2 diabetes continues to rise steadily. The burden of these diseases does not affect communities uniformly. While known factors such as diet, physical activity, and socioeconomic conditions play a role, studies have demonstrated the involvement of the gut microbiota in the development of metabolic disorders, particularly obesity and insulin resistance. However, … |
INSTITUT PASTEUR | 2026-03-09 |
| 94 | Investigating The Relationships Between Body Composition, Waist/Hip Ratio, Peripheral Muscle Strength, and Cough Force in Healthy Young Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: Body mass index (BMI) is a key parameter used for obesity classification and the evaluation and monitoring of individuals’ health status. Obesity, described by the World Health Organization as a major global epidemic, remains one of the most significant preventable and manageable conditions contributing to increased risks of cardiovascular and metabolic diseases. In addition to BMI, anthropometric measurements such as the waist-to-hip ratio are crucial indicators for risk assessment. While numerous studies in the literature have addressed the detrimental effects of obesity on respiratory functions, … |
NAZIRE NUR YILDIZ; | 2025-12-31 |
| 95 | The Effects of Tirzepatide Use on Muscle and Vascular Function Among Obese Older Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity and type 2 diabetes mellitus (T2DM) represent major public health concerns in the aging community. Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist recently approved for the treatment of T2DM and obesity has been shown to be effective at reducing weight, improving markers of T2DM control, and improving cardiovascular health. Utilization of tirzepatide among older adults has been on the rise since FDA approval was issued, … |
SHREYA RAO; | 2026-01-16 |
| 96 | Utilizing Dietician-guided Intervention to Combat Neurogenic Obesity in People With Spinal Cord Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the effects of a 9-week dietician-guided program modified from the National Diabetic Prevention Program (modified DPP-diet) in people with spinal cord injury on body composition and insulin sensitivity. The main question it aims to answer is: Does 9 week modified DPP-diet reduce body fat percentage and insulin resistance? Participants will: Have 9 weeks of Telehealth visit with dietician certified in providing DPP. Visit the laboratory before, … |
YI-TING TZEN; | 2026-03-31 |
| 97 | School Meals in Denmark: Evaluation of A National School Meal Pilot Program on Children’s Health, Learning and Well-being – A Natural Experiment PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study looks at how a national school meal program affects the health, well-being, and learning of Danish schoolchildren aged 10 to 15 years. The study is part of the Danish National School Meal Pilot Program (2025-2028), which provides free school meals at selected public schools. Some school classes receive free school meals, while other classes do not and are used for comparison. Children are followed for about 1.5 years. Information is collected before and after the program using simple health measurements, questionnaires about well-being, … |
NIKOLAI NORDSBORG; | 2026-02-05 |
| 98 | A Phase 1 Drug-Drug Interaction Study of ABBV-295, Levonorgestrel, and Ethinyl Estradiol in Healthy Adult Female Subjects With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This Study of ABBV-295 subcutaneous injections will assess pharmacokinetics and adverse events in healthy adult women participants with overweight or obesity taking oral contraceptives. |
ABBVIE | 2026-02-17 |
| 99 | A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate The Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Moderate to Severe Obstructive Sleep Apnea, and Obesity or Overweight PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the studies is to evaluate the efficacy and safety of eloralintide in participants with moderate-to-severe obstructive sleep apnea and obesity or overweight. YDAO is a master protocol designed to support two independent studies: YSA1 and YSA2. Study YSA1 will include participants who are unable or unwilling to use Positive Airway Pressure (PAP) therapy and study YSA2 will include participants who are on PAP therapy for at least 3 months at time of screening and plan to continue PAP therapy during the study. Participants will be assigned to the Intervention-Specific Appendix (ISA) that reflects their current PAP usage. Participation in the study will last about 76 weeks. |
RANDALL QUINN; | 2026-03-20 |
| 100 | A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate The Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Persistent Obesity or Overweight Treated With A Weekly Incretin, With and Without Type 2 Diabetes PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks. |
NOVA LAW; | 2026-03-20 |
| 101 | Evaluation of Food Additive Contributions to Obesity: Pilot Study 1 PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The effects of food additives on body weight in humans are largely unknown. This is a pilot cross-over double blind RCT in obese adults aimed to test the feasibility of measuring food consumption over 24 hours after one-time administration of K sorbate versus placebo after participants reduce the background consumption of related food additives. |
NATALIA MCINNES; | 2026-02-27 |
| 102 | A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate The Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening. |
HARRY STUDDARD; | 2026-03-20 |
| 103 | Single-centre Study Investigating The Role of Long-acting Subcutaneous Glucose-dependent Insulinotropic Polypeptide Receptor Agonist (GIP RA) in Combination With Long-acting Subcutaneous Amylin Receptor Agonist on Gastrointestinal Tolerability in Participants With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This trial is being done to look at the safety and effect of combining cagrilintide and NNC0480-0389 in people living with overweight and obesity compared to taking cagrilintide alone. In one period participants will get two medicines: cagrilintide and NNC0480-0389. In the other period, … |
NOVO NORDISK | 2026-02-17 |
| 104 | An Open-Label Study of Mibavademab (REGN4461), A Leptin Receptor Agonist, for The Treatment of Monogenic Obesity Due to Biallelic Loss of Function Variants of The LEP Gene Related Papers Related Patents Related Grants Related Experts Highlight: This study is researching an experimental drug called mibavademab. The study is focused on patients with a condition called monogenic obesity. Monogenic obesity is caused by a change in the leptin gene that keeps it from working properly. This causes the body to not be able to feel full or control feelings of hunger. The aim of the study is to see how well mibavademab controls the body weight and how safe it is. The study is looking at several other research questions, … |
REGENERON PHARMACEUTICALS | 2026-03-10 |
| 105 | Scalp Hair Metabolomics As A Novel Biomarker of Poor Metabolic Health in Individuals With Severe Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to investigate how body weight and weight-loss surgery affect the natural chemicals found in scalp hair over time. We will also find out how common and severe hair thinning/hair loss and muscle loss are in the first 6 months after bariatric surgery. |
HONG CHANG TAN; | 2026-02-13 |
| 106 | A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate The Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years. |
MOHAMMAD ARYANPURE; | 2026-03-20 |
| 107 | Acute Effects of Water Extract of Crocus Sativus Tepals on Metabolic Health Parameters in Patients With Obesity and Prediabetes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine the acute effects of ingestion of a cold aqueous extract of Crocus sativus tepals on postprandial glycemia and other indicators of metabolic health in patients with obesity and/or prediabetes. The main questions it aims to answer are: * Does the ingestion of Crocus sativus tepals cold aqueous extract prior to a meal improve the glycemic response to a standard meal? * How does the ingestion of Crocus sativus tepals aqueous extract prior to a meal impact insulin levels and other markers of metabolic health? * Does the ingestion of Crocus sativus tepals cold aqueous extract prior to a meal increase the resting energy expanditure? Researchers will compare Crocus sativus tepals cold aqueous extract to cold water. The participants will visit the Faculty twice – on one visit they will ingest Crocus sativus tepals cold aqueous extract and on the other cold water (in random order) 5 minutes prior to a standard meal of 100 g of white bread. On each visit, anthropometric measurements will be performed upon arrival. Blood samples will be collected 3 times, preceeded by resting metabolic rate and blood pressure measurements: at baseline in fasted conditions, and 60 minutes and 120 minutes after consuming the bread. There will be an at least 7 days wash-out period between the two visits. |
NINA MOHORKO; | 2026-02-04 |
| 108 | Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: glaucoma is prevalent among obstructive sleep apnea (OSA). contnous passive airway pressure is main treatment of OSA. lifestyle corrections also recommended |
ALI MOHAMED ALI ISMAIL; | 2026-03-03 |
| 109 | Acute Effect of Apple Cider Vinegar Consumption on Postprandial Plasma Malondialdehyde Level in Adult With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Research on the benefits of apple cider vinegar has tended to focus on its hypoglycemic effects and lipid profile changes during long-term consumption, without exploring its acute effects on oxidative stress during short-term consumption. Therefore, this study aimed to determine whether apple cider vinegar consumption affects postprandial plasma MDA levels in obese adults. The hypothesis of this study is that apple cider vinegar consumption has an acute effect on changes in postprandial plasma MDA levels in obese adult subjects. Subject criteria are adults aged 19-59 years; obese nutritional status; … |
IKA HANDAYANI; | 2026-02-24 |
| 110 | A PHASE 1, OPEN-LABEL, RANDOMIZED, SINGLE DOSE, PARALLEL GROUP STUDY TO ASSESS RELATIVE BIOAVAILABILITY OF PF-08653944 WHEN ADMINISTERED ACROSS DIFFERENT INJECTION SITES IN ADULTS WITH OVERWEIGHT OR OBESITY PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is being done to learn how the study medicine affects the body and how safe it is for people who take it. The researchers will look at a number of health tests, including blood tests such as calcitonin, amylase, and lipase, because similar medicines have sometimes caused changes in these tests. This study is seeking participants who are: * Adults who are obese or overweight with weight-related health conditions, … |
PFIZER | 2026-02-27 |
| 111 | Mapping Metabolic Organ Plasticity in Energy Adaptation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Brief Summary (Plain Language) Many people who lose weight experience a slowdown in their metabolism that is greater than expected. This response, called metabolic adaptation, makes it harder to continue losing weight or to keep weight off over time. The biological reasons for this slowdown are not fully understood. Some organs in the body, especially the liver and kidneys, use a large amount of energy even when the body is at rest. Although these organs make up only a small portion of body weight, … |
GEPNER YFTACH; | 2026-02-17 |
| 112 | Peri-Intubation Adverse Airway Events in Critically Ill Patients With Morbid and Super Obesity: A Retrospective Analysis Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the incidence and characteristics of peri-intubation adverse airway events in critically ill trauma patients with morbid obesity versus those with super obesity, and to determine whether increasing BMI independently predicts severe peri-intubation complications. |
ZELIHA ALICIKUS; | 2026-02-18 |
| 113 | Efficacy and Safety of Tirzepatide Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Are Overweight With Weight-Related Comorbidities: A Randomized, Double-Blind, Placebo-Controlled Trial (SURMOUNT-1) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This Phase 3 study evaluates the efficacy and safety of once-weekly subcutaneous tirzepatide (a dual GIP and GLP-1 receptor agonist) at 5 mg, 10 mg, or 15 mg versus placebo, each used with a reduced-calorie diet and increased physical activity, in adults without type 2 diabetes who have obesity or are overweight with weight-related comorbidities. The primary efficacy assessment is at Week 72. Participants with prediabetes at randomization may continue in an additional long-term treatment period to assess progression to type 2 diabetes and longer-term weight outcomes. |
HUDSON BIOTECH | 2026-03-19 |
| 114 | Impacts of Prolonged Exposure to Added Sugar Warning Labels on Explicit Weight Bias: A Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to examine the effects of added sugar warning labels for sugar-sweetened beverages (SSBs) on explicit weight bias and body weight attributional judgements. Participants will be assigned to view either control labels or added sugar warning labels applied on SSBs in an experimental store. Participants will shop for beverages in the store and take a computer survey during four visits to the store, spaced approximately one week apart. |
ALINE D’ANGELO CAMPOS; | 2026-01-30 |
| 115 | A Study Investigating Safety, Tolerability and Efficacy of UBT251 in Participants Living With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this clinical study is to find out if UBT251 is safe and effective for treating people who are living with overweight or obesity. Participants will get either UBT251 (the treatment being tested) or Placebo (a treatment that has no active medicine in it), which treatment participants get is decided by chance. |
NOVO NORDISK | 2026-02-17 |
| 116 | A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety, and Pharmacodynamics of MOTS-c (a Mitochondrial-Derived Peptide) in Adults With Prediabetes and Overweight/Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This Phase 2a study evaluates whether 12 weeks of treatment with investigational MOTS-c improves insulin sensitivity compared with placebo in adults with prediabetes and overweight/obesity. Participants are randomized 1:1 to MOTS-c or placebo, receive standardized lifestyle counseling, and are followed for safety through Week 16. |
HUDSON BIOTECH | 2026-04-01 |
| 117 | Clinical Significance and Prognostic Value of Systemic Immune Inflammation Index and Systemic Inflammation Response Index in Obesity and Associated Metabolic Complications PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims to evaluate the diagnostic and prognostic value of the systemic immune-inflammatory index (SII) and the systemic inflammation response index (SIRI) in individuals with overweight or obesity. The study will assess their association with obesity status, metabolic complications, lifestyle patterns, dietary indices, and established inflammatory biomarkers. Participants will undergo anthropometric assessment, laboratory testing, dietary evaluation, and follow-up for response to different obesity treatment modalities over 3 years. The study intends to determine whether SII and SIRI can serve as clinically useful predictors of metabolic risk and treatment outcomes of obesity. |
GORDANA KENĐEL JOVANOVIĆ; | 2026-02-24 |
| 118 | Assessing Biological Aging in A Real-World Medical Weight Loss Program Using The LinAge2 Clinical Clock PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study examines whether routine treatment with semaglutide or tirzepatide, prescribed with lifestyle coaching in a real-world weight-management program, is associated with changes in biological age measured by the LinAge2 clinical aging clock over 6 months. |
JAN GRUBER; | 2026-03-02 |
| 119 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Clinical Study to Evaluate The Efficacy and Safety of MDR-001 Administered Orally Over 52 Weeks in Participants With Overweight or Obesity (MOBILE) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, double-blind, placebo-controlled, phase III clinical study to evaluate the efficacy and safety of the oral small molecule MDR-001 Tablets over 52 weeks as an adjunct to a lifestyle intervention in participants with overweight or obesity.The goal of this clinical trial is to determine whether the oral drug MDR-001 can improve weight management in adult participants with overweight or obesity. |
MINDRANK AI | 2025-12-22 |
| 120 | Analysis of The Transmission of Overweight/Obesity in The Mother-breastmilk-child Triad in Relation to Maternal Cardiometabolic Status and Diet PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The prospective 5-month follow-up study will involve 150 mother-infant dyads grouped based on maternal baseline BMI category (normal weight, overweight, obesity). The investigators plan 3 study visits (1, 3, and 6 months postpartum) with analysis the following parameters and outcomes: 1. maternal anthropometry and body composition; 2. maternal dietary intake and dietary patterns (with results of biomarker-based validation); 3. maternal status of lipophilic antioxidants, selected vitamins, and fatty acids profile that may be related to adipose tissue metabolism, inflammation, and cardiometabolic status; 4. maternal metabolomics, adipokines, insulin, selected biomarkers of inflammation, altered glucose metabolism, and oxidation; … |
MONIKA ZIELINSKA-PUKOS; | 2026-03-09 |
| 121 | Multiomic Evaluation of The Effect of Artichoke By-products Supplementation Rich in Hydroxycinnamic Acids, Integrated Into An Energy-restricted Mediterranean Diet, on The Prevention of Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The ARTI-UP study evaluates whether daily consumption of a supplement made from artichoke by-products, rich in hydroxycinnamic acids (HCAs), in combination with an energy-restricted Mediterranean diet (erMeDiet), can improve glycaemic control, reduce insulin resistance and contribute to weight loss in subjects with overweight or obesity. In addition, it seeks to understand the biological mechanisms involved using omic techniques and to establish predictive biomarkers that will enable progress towards personalised nutrition strategies. |
SONIA GARCÍA CALZÓN; | 2026-02-17 |
| 122 | Impact of Obesity on Response to Therapy and Clinical Outcom in Patients With Inflammatory Bowel Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Inflammatory Bowel Disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a group of chronic relapsing inflammatory disorders of the gastrointestinal tract. Its pathogenesis is multifactorial, involving genetic predisposition, environmental triggers, immune dysregulation, and microbial imbalance. IBD has significant morbidity and a major impact on quality of life, with varied clinical presentations and disease behavior (1,2). Obesity, defined as excessive body fat accumulation, … |
AYA AHMED MAHMOUD ABDELMOHSEN; | 2026-01-15 |
| 123 | A Randomized, Double-blind, Placebo-controlled Trial to Access The Efficacy and Safety of Akkermansia Muciniphila AKM Lab-01 in Participents With Overweigh and Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed as a preliminary investigation to evaluate the weight-loss efficacy and safety of AKM Lab-01 in an overweight or obese population. It is an interventional, radomized, double-blind, placebo-controlled clinical trial. Participants who meet the eligibility criteria will be randomly assigned to receive AKM Lab-01 or a matching placebo. The intervention will be administered once daily for 3 months. Baseline metrics, along with blood, urine, and stool samples, will be collected from participants, before and after the AKM Lab-01 intervention. The analysis will focus on changes in body weight, blood lipids, blood glucose, … |
MOON GUANGZHOU BIOTECHNOLOGY | 2026-01-15 |
| 124 | Evaluating The Food Education Access Support Together (FEAST) Perinatal Support Program: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Latino individuals face an elevated risk of adverse health outcomes during pregnancy, impacting both the birthing parent and the baby with potential long-term chronic health conditions. While promoting a healthy diet during pregnancy is a promising strategy, interventions targeting dietary behaviors have yielded mixed results and lack widespread dissemination in communities in need. Collaborating with community-based organizations could enhance cultural relevance, build trust with Latino families, and improve program reach and effectiveness. Food Education Access Support Together (FEAST) is a community-based program that promotes healthy eating, well-being, and health equity for diverse, … |
TYLER MASON; | 2026-02-02 |
| 125 | Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity. |
JOSÉ MANUEL PÉREZ CASILLAS; | 2026-03-03 |
| 126 | CLINICAL TRIAL ON THE EFFECT OF SUPERVISED PHYSICAL EXERCISE AFTER BARIATRIC SURGERY ON MUSCLE MASS AND BONE DENSITY (OBEFIT STUDY) PF:2 Related Papers Related Patents Related Grants Related Experts Abstract: Introduction Background and rationale Obesity is currently a complex disease that has reached pandemic proportions and affects millions of people worldwide. Bariatric surgery can … |
ISAÍAS ALARCÓN DE AGUA; | 2026-01-08 |
| 127 | Testing A Dissonance-Based Intervention to Reduce Ultra-Processed Food Consumption Via Activism Against The Food Industry PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The DISRUPT clinical trial will test two different 2-month programs to help adults with overweight/obesity (N=60) reduce their intake of ultra-processed foods (UPFs). Participants will be randomly assigned to receive standard dietary change strategies, cognitive dissonance strategies that engage them in activism against the UPF industry, or both. All participants will attend an introductory educational workshop about UPFs. If they are assigned to receive one or more of these strategies, they will attend weekly group sessions with the relevant intervention content for 7 more weeks. Groups will be held virtually. |
CHARLOTTE HAGERMAN; | 2025-11-10 |
| 128 | Impact of Semaglutide Withdrawal on Cardiometabolic Profile and Physiology of Energy Balance: A Randomized Controlled Trial Comparing Gradual Dose Reduction With Immediate Treatment Cessation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Semaglutide is a medication from the class of drugs called glucagon-like peptide-1 agonists that promote weight loss. There is little clinical data on the best strategy to achieve weight maintenance following weight reduction induced by semaglutide. For people who need to discontinue treatment, it is unknown whether the weight regain, its accompanied health benefits could be ameliorated with a gradual reduction in semaglutide. The investigators will study if a gradual reduction of semaglutide is associated with different heart risk profile and hormones involved in energy regulation as compared to immediate treatment cessation. |
MOUNT SINAI HOSPITAL CANADA | 2026-02-11 |
| 129 | The Effect of A Low-Calorie Diet Rich in Medium-Chain Triglycerides Based on Traditional Minangkabau Foods on Lipid Profile, Leptin Levels, and DNA Methylation of The Leptin Gene Promoter in Individuals With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity. The traditional Minangkabau foods used in this study consist primarily of coconut milk-based dishes, which contain coconut oil as a natural source of MCTs. The metabolic biomarkers assessed include body mass index (BMI), waist circumference, systolic and diastolic blood pressure, body fat percentage, fasting blood glucose levels, lipid profile, leptin concentrations, and DNA methylation of the leptin gene promoter. Based on these metabolic biomarker measurements, … |
NOLA VITA SARI; | 2026-03-05 |
| 130 | Impact of Obesity on The Efficacy of Bilateral Tibial Nerve Stimulation in Obstructed Defecation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obstructed defecation syndrome (ODS) is a common functional bowel disorder characterized by difficulty in stool evacuation. Bilateral posterior tibial nerve stimulation (BT PTNS) has emerged as a noninvasive, safe, and effective therapeutic option for functional ODS, improving symptom severity and quality of life. |
MOHAMED HANY ASHOUR; | 2026-02-05 |
| 131 | Safety and Effectiveness of Tirzepatide(Spartina )in Chronic Kidney Failure A Single-center Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Diabetes management presents a complex clinical scenario marked by several challenges, especially in chronic kidney failure. These include navigating potential drug interactions between oral antidiabetic therapies and other agents. Furthermore, these patients may experience various adverse drug effects, such as lactic acidosis, electrolyte abnormalities such as hypomagnesemia, fluid retention, and lipid derangements, which can further augment overall morbidity. Consequently, many patients receive insulin. However, prolonged intensive insulin therapy may be linked to several adverse outcomes, including an increased risk of hypoglycemia and weight gain. Hence, … |
NOOSHIN DALILI; | 2025-12-15 |
| 132 | Long-Term Effects of Walnut Consumption on Brain Function in Men and Women With Abdominal Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation. It is therefore important to investigate the specific effects of walnuts on cerebral blood flow responses before and after intranasal insulin administration, as well as their associated functional benefits. The investigators hypothesize that long-term walnut consumption improves vascular function and insulin-sensitivity in the brain, … |
PETER J. JORIS; | 2026-02-19 |
| 133 | The Effect of Semaglutide on The Intestinal Flora in Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: For obese individuals, semaglutide treatment was adopted. By using multi-omics techniques such as fecal metagenomic sequencing and based on in vitro strain screening platforms, the effects and specific mechanisms of semaglutide on the intestinal flora of obese patients were clarified. |
BEIJING CHAO YANG HOSPITAL | 2026-01-07 |
| 134 | Transpulmonary Assessment for Individualized Lung Optimization in Patients Living With Obesity Research – Positive End-Expiratory Pressure PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This protocol describes a randomized controlled feasibility vanguard study designed to investigate the implementation and effects of esophageal pressure-guided positive end-expiratory pressure (PEEP) titration in patients with high body mass index (BMI) mechanically ventilated patients at the Edmonton Zone. The study will enroll 30 patients with body mass index (BMI) \>=30 kg/m2 who require invasive mechanical ventilation, randomizing them in a 1:1 ratio to receive either esophageal pressure-guided PEEP titration or standard care management. The primary objective focuses on establishing the feasibility of conducting a larger definitive trial, while secondary objectives examine differences in applied PEEP levels, respiratory mechanics, … |
UNIVERSITY OF ALBERTA | 2026-01-22 |
| 135 | Mechanisms Mediating Reversible Lipotoxicity of The Pancreas in Obesity-induced Type 2 Diabetes: Edinburgh Diabetes Remission Study (EDRS) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate how fat accumulation in the pancreas contributes to the development of type 2 diabetes (T2D), and how weight loss may reverse this process. Previous research has shown that reducing body weight can lead to diabetes remission, and this was accompanied by lowering intrapancreatic fat and restoration of insulin secretion, but the mechanisms behind this are not fully understood. In particular, … |
AHMAD AL-MRABEH; | 2026-03-04 |
| 136 | A Real-World Study on The Impact of Weight Loss on Treatment Efficacy in Overweight/Obese Patients With Plaque Psoriasis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this investigator-initiated, real-world, observational study is to investigate the impact of weight loss on treatment efficacy in overweight or obese Chinese patients with moderate-to-severe plaque psoriasis. The main question it aims to answer is: Does a structured weight loss intervention (including dietary management, exercise, and/or pharmacotherapy) improve the clinical response to psoriasis therapy in this population, … |
GUO JIN-ZHU; | 2026-02-02 |
| 137 | Comparative Effectiveness of Dulaglutide, Semaglutide, and Tirzepatide in Preventing Cardiovascular Events in Patients With Type 2 Diabetes and Obesity With or Without Atherosclerotic Cardiovascular Disease PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials. The investigators’ goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies. |
SHIRLEY VICHY WANG; | 2026-02-18 |
| 138 | Novel Respiratory Muscle Training for Improving Cerebrovascular Function and Immune Status in Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Millions of adults in America have too much body fat, resulting in obesity. Obesity is detrimental to health and causes disease. Obesity reduces brain health, which causes the brain to function less effectively. Additionally, a lack of exercise contributes to poorer brain health. Most individuals feel they do not have time to exercise. There is a need for a quicker type of training that improves brain health. Newly developed breathing exercises could be a time-efficient, cost-effective, … |
JOSEPH WATSO; | 2026-02-13 |
| 139 | Optimizing Self-Monitoring Feedback Delivery for The Treatment of Overweight and Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to learn how to best provide weekly feedback on individual progress toward intervention goals during a weight loss program. |
KATHRYN M. ROSS; | 2026-01-28 |
| 140 | Research of Predictive Factors of Weight Loss After Bariatric Surgery in Patients Suffering From Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: As with other nutritional strategies, the clinical response to bariatric surgery can be highly variable, with weight regain being a frequent occurrence. Among multiples factors, co-occurrence of eating disorders such as binge eating disorder has been implicated in insufficient clinical response. Improving our ability to predict how patients will respond to surgery is necessary in order to tailor the care pathways we offer. The mechanisms involved in disturbances of eating behaviour before and after surgery remain largely unknown. This study aims to identify the predictive factors of weight loss after bariatric surgery, … |
YANNICK DESWYSEN; | 2026-02-11 |
| 141 | A Randomized, Open-label, Single Dose, Two-way, Crossover, Phase 1 Clinical Trial to Compare and Evaluate The Safety and Pharmacokinetics After Subcutaneous Injection of HUC2-676 or HUC2-676-R in Healthy Adult Subjects PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The trial uses a randomized, open-label, single-dose administration per period, and a 2 x 2 crossover design where subjects receive both treatments sequentially with a washout. |
HUONS | 2026-01-13 |
| 142 | A Phase 3b Study to Investigate The Efficacy and Safety of Different Retatrutide Dose Escalation Schemes in Participants Without Type 2 Diabetes Who Have Obesity or Overweight: A Randomized, Controlled, Double-Blind Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate the efficacy and safety of different retatrutide dose escalation schemes in participants without type 2 diabetes who have obesity or overweight. Participation in the study will last about 113 weeks. |
LOUISE TABER; | 2026-03-20 |
| 143 | Immediate Effect of Whole-Body Vibration on Cardiovascular Response and Functional Capacity in Overweight/Obese Young Women PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity has become a major global public health issue, defined by an excessive accumulation of body fat that presents substantial health risks. Over 650 million adults worldwide suffer from obesity, which is defined as having a Body Mass Index (BMI) of 30 or higher. Obesity is becoming more common in both developed and developing countries. Sedentary lifestyles, unhealthy eating habits that include processed foods and sugars, and genetic factors are the main causes of the rising prevalence of obesity. Obesity is a multifactorial condition that affects physical appearance and self-esteem, while also having significant implications for long-term health, … |
ROKAIA ALI ZAINELABEDEEN MOHAMED TOSON; | 2025-12-12 |
| 144 | Interscalene Vs Phrenic-sparing Blocks in Obesity: Effect of Pre-operative Maximum Inspiratory Pressure in A Randomized Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether a phrenic-sparing nerve block can lower early breathing problems after shoulder surgery in adults with obesity, and whether a simple breathing-strength test (maximum inspiratory pressure, … |
MONIKA NANDA; | 2026-01-28 |
| 145 | A Phase II, Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy and Tolerability of GL0034 Among Type II Diabetes Mellitus Subjects Who Are Obese or Overweight With Weight-related Comorbidities PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase II, randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of GL0034 among type II diabetes mellitus subjects who are obese or overweight with weight-related comorbidities. Subjects will be put on either one of the four treatment arms (GL0034, once a week, subcutaneous injection) or placebo arm (once a week, subcutaneous injection) following initial dose-up titration that takes up to approximately 20 weeks. The primary end point is change in HbA1c levels from baseline (Week 0) to Week 36 following treatments in all participants. |
SUN PHARMACEUTICAL INDUSTRIES | 2026-03-18 |
| 146 | Ultrasound Assessment of Anterior Neck Soft Tissue Thickness to Predict Difficult Airway Risk in Obese Patients Undergoing for Surgery Under General Anesthesia: An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obese patients are at increased risk of difficult airway management due to anatomical changes in the anterior neck soft tissues. Accurate preoperative prediction of difficult airway remains challenging using conventional clinical airway assessment tests alone. This prospective observational study aims to evaluate the role of ultrasound assessment of anterior neck soft tissue thickness in predicting difficult airway risk in overweight and obese adult patients undergoing elective surgery under general anesthesia. Ultrasound-based anterior neck measurements will be compared with standard clinical airway assessment parameters to determine their diagnostic accuracy for difficult laryngoscopy and intubation. The results of this study may contribute to improved preoperative airway risk stratification and safer airway management in obese patients. |
GAMZE NUR TEKE; | 2026-01-16 |
| 147 | Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Several drugs have been shown effective in the treatment of obesity, with concomitant favourable cardiovascular effects. Today, there are no studies on novel anti-obesity drugs in patients with adult congenital heart disease (ACHD). Therefore, the investigators aim to study the effects of the anti-obesity drug tirzepatide (Munjaro) on cardiovascular and metabolic factors in obese patients with ACHD. In a 24-week, randomized, open-label, … |
KATJA PROKSELJ; | 2026-01-21 |
| 148 | Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder – OBOE-Mayo PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to identify the specific characteristics (phenotypes) that may be useful to help select the right medication for weight loss, and to study the effect of individualized guided medication in patients with bipolar disorder ages 18-65. The main questions it aims to answer are: * Can the investigators compare the distribution of obesity characteristics (hungry brain, hungry gut, … |
MARK FRYE; | 2026-03-11 |
| 149 | Validation of The Accuracy of Heart Rate Monitors at Resting and Exercise at Maximal Fat Oxidation Rate in Overweight and Obese Young Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Overweight and obesity are defined as an excessive accumulation of body fat that affects health. According to data from the World Health Organization (WHO), in 2022, there were 2.5 billion adults aged 18 years and older who were overweight, of whom 890 million were obese. In other words, 43% of adults aged 18 years and older were overweight, and 16% of them were obese. Overweight and obesity are key risk factors for various chronic diseases such as diabetes, hypertension, cardiovascular disease, and even some types of cancer. There is evidence that mortality from cardiovascular disease, … |
MARCO ANTONIO HERNÁNDEZ LEPE; | 2025-09-19 |
| 150 | Effects of Personalized Nutrition Coaching on Body Composition, Dietary Intake, Physical Activity Among Overweight and Obesity Nurses at Indonesian Hospital: A Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity among healthcare workers has become an increasing public health concern, with potential consequences for work productivity, quality of care, and long-term health outcomes. Despite their role in promoting health, healthcare workers often face demanding schedules, high stress levels, and limited access to structured health promotion programs, placing them at elevated risk for overweight and obesity. In the absence of targeted workplace interventions, these conditions may persist and worsen over time, highlighting the need for effective, sustainable, … |
TAZKIAH SYAHIDAH; | 2026-03-06 |
| 151 | Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, controlled clinical trial with a two-sided superiority hypothesis. The study evaluates whether a 12-week pre-treatment with semaglutide prior to ovarian stimulation improves the number of good-quality blastocysts in overweight and obese women undergoing in vitro fertilization (IVF), compared to no pre-treatment. |
NIKOLAOS P POLYZOS; | 2026-01-21 |
| 152 | Intermittent Cottonseed Oil Consumption on Cardiovascular Disease Risk Reduction PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States’ growing disease burden. Cottonseed oil (CSO) is found readily in the food supply, … |
JAMIE COOPER; | 2026-01-23 |
| 153 | Comparison Study to Evaluate The Outcomes Among Children Participating in A Community Healthy Lifestyle Program PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the outcomes of an existing clinical program that teaches families of children with overweight and obesity healthy lifestyle. The design will be unblinded, randomized, waitlist control. |
SARAH BARLOW; | 2026-03-30 |
| 154 | Metabolic Changes Associated With Weight Gain After Treatment of Achalasia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This goal of the study is to assess the effect of weight gain in patients with achalasia after they are treated. The main question to be answered is if weight gain after achalasia treatment is associated with worsening metabolic status. Patients will be compared between their baseline status at the time of treatment and 1 year after treatment. Participants will have metabolic tests performed at these 2 times including blood tests. |
DANIEL COHEN; | 2026-01-13 |
| 155 | Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will evaluate the effects of oral semaglutide in combination with topical corticosteroid/calcipotriol on clinical outcomes and metabolic inflammation in patients with plaque psoriasis and overweight/obesity and/or type 2 diabetes mellitus. A total of 62 participants will be randomized to receive either semaglutide plus topical corticosteroid/calcipotriol or placebo plus topical corticosteroid/calcipotriol for 12 weeks. Clinical efficacy will be assessed using the Psoriasis Area and Severity Index (PASI), and quality of life will be evaluated using DLQI, PROMIS-29, and EQ-5D-5L. Systemic inflammatory markers will also be measured to assess metabolic inflammation. |
JORGE VALDESPINO VALDES; | 2026-02-11 |
| 156 | Evaluation of Serum Betatrophin Levels in Normal-Weight and Overweight Adolescents With Polycystic Ovary Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in adolescents and women of reproductive age and is frequently associated with insulin resistance and an increased risk of metabolic complications. The mechanisms underlying these metabolic abnormalities are not fully understood. Betatrophin (angiopoietin-like protein 8, ANGPTL8) is a liver- … |
MERVE DIDEM EŞKIN TANRIVERDI; | 2026-03-18 |
| 157 | Tirzepatide Combined With Cognitive-Behavioural Therapy (CBT) for Adults With Alcohol Use Disorder (AUD) and Overweight/Obesity (OOB) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators approach is to conduct a Phase II Double-Blind randomised controlled trial with individuals with co-occurring Alcohol Use Disorder and overweight/obesity (AUD-OOB) to receive either a sub-cutaneous injection of Tirzepatide (2.5 mg for 4 weeks followed by 5 mg for 4 weeks) or visually matched sham saline injection, in combination with a structured behavioural intervention (Take Control CBT Module). The primary aim of the study is evaluate the efficacy of the intervention on the number of heavy drinking days (defined as 5+ standard drinks for men, … |
KIRSTEN MORLEY BPSYCH MPH PHD; | 2025-12-18 |
| 158 | A Study to Evaluate The Effect of Fasting Duration and Temporary Withholding of Tirzepatide on Retained Gastric Contents Using Gastric Ultrasound in Participants With Type 2 Diabetes Mellitus and Participants With Overweight or Obesity Without Type 2 Diabetes Mellitus PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate how fasting and stopping the use of tirzepatide affects the amount of food and drink that stays in the stomach after a meal. Ultrasound will be used to check the stomach content after a test meal. |
NOEL VARGHESE; | 2026-03-04 |
| 159 | Eat Healthy, Grow Healthy: Strategies to Promote Fruit and Vegetable Intake Among Preschoolers in Denton County to Prevent Childhood Obesity and Related Health Complications PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Eat Healthy, Grow Healthy (EatGrow) program is a family-based, fully virtual nutrition education intervention designed to improve fruit and vegetable intake among preschool-aged children. Parents and their children participate together in interactive online lessons over eight weeks, including parent-child cooking, taste-testing, and engaging nutrition education. Recruitment was conducted via schools, but schools are not involved in delivering the program. The study measures changes in children’s fruit and vegetable intake and willingness to try new foods, as well as parental nutrition literacy, attitudes, and self-efficacy. Weekly tasks are included for engagement. |
KATHLEEN E DAVIS; | 2026-03-27 |
| 160 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to demonstrate that KAI-9531 subcutaneous (SC) injection once weekly is superior to placebo on: * Percent change in body weight * Change in hemoglobin A1c (HbA1c) |
KAILERA | 2026-03-31 |
| 161 | The BRAVE Study: A Sensitivity Intervention With Nursing Students Using Simulation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial will be a curriculum-embedded weight sensitivity training program. There will be two groups. The control group will receive the standard obesity lecture (SOL) and the intervention group will receive the BRAVE Intervention (BRAVE: Building Respect and Acceptance through Valuing Everybody); a Weight Bias Reduction (WBR) intervention. Both groups will have two simulation encounters with standardized patients who are living with obesity and the outcome will be to improve weight bias and increase weight sensitivity over one year. Participants will include second- … |
TRACY L OLIVER; | 2026-01-13 |
| 162 | A Phase 1, Randomized, Double-blind, Placebo-controlled Single Ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered SGB-7342 in Subjects With Obesity or Overweight PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety and tolerability of subcutaneously administered SGB-7342 in adult subjects with obesity and overweight. |
SUZHOU SANEGENE BIO | 2026-01-09 |
| 163 | Women, Weight, and Well-Being: An Observational Study of An Interdisciplinary Lifestyle Program With or Without GLP-1 Therapy to Support Intentional Weight Loss, Reduce Internalized Weight Bias, and Improve Positive Health Behaviors in Women With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Women, Weight and Well-Being is a 12-month research study looking at how a supportive lifestyle program may help women whose weight increases their risk for heart disease. We want to understand whether taking part in the program is linked with changes in: body weight and waist size; blood pressure and bloodwork related to heart health (such as cholesterol and A1C); health habits (movement, eating patterns, sleep); well-being and how women feel about their bodies, including the effects of weight stigma. About 60 women aged 35-75 will take part. Participants will attend group sessions and have one-on-one support from a nurse, … |
HEATHER CONRADSON; | 2026-03-31 |
| 164 | Effect of AURICULAR Vagus Nerve Stimulation on Glucose Tolerance, and Mood States in Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Avoid unhealthy foods, walk every day for at least 15 min , sleep well, he should take sessions at its time, family should Avoid disturbances, keep quiet as much as possible, make Analysis recoired before and after interaction. |
ENAS WAGDY ELSAID AHMED; | 2026-01-13 |
| 165 | Gastro-Intestinal Digestion and Physiology After Bariatric Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to characterize gastrointestinal digestion and physiology in patients after bariatric surgery, or people living with obesity. The main question it aims to answer is: what is the status of gastrointestinal digestion and physiology after bariatric surgery? Participants will have two study visits: 1) participants will undergo collection of gastrointestinal samples and 2) participants will ingest an ingestible capsule that measures multiple physiological parameters along the gastrointestinal tract. |
UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN | 2026-01-20 |
| 166 | Efficacy, Safety and Pharmacokinetics of Cagrilintide S.c. 2.4 Mg As Monotherapy and in Combination With Semaglutide S.c. 2.4 Mg (CagriSema) Once Weekly for Weight Management in Chidren and Adolescents With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will look at how well CagriSema and cagrilintide help children and adolescents with excess body weight lose weight. The study has 2 parts: main and extension study. In the main study, participants will either get CagriSema (a new study drug), cagrilintide (a new study drug), semaglutide (a drug that doctors can already prescribe to adolescents and adults) or placebo (a placebo looks like the treatment being tested, … |
NOVO NORDISK | 2026-04-02 |
| 167 | Endoscopic Suture Gastroplasty (ESG) for Treatment of Obese Patients With Endometrial Cancer: A Prospective, Multicenter, Observational Study (ESG-ENDO) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity increases the risk of endometrial cancer, with higher Body Mass Index (BMI) leading to a significant increase in both cancer risk and recurrence. Because of the excellent cancer-specific outcomes and preponderance of obesity-related complications, women with endometrial cancer are more likely to die of cardiovascular disease and other obesity-related illnesses than endometrial cancer itself. This makes an endometrial cancer diagnosis a critical moment to emphasizes the importance of actively managing the underlying issue of obesity in the endometrial cancer survivorship period. Bariatric surgery has shown long-term benefits, including weight loss and reduction of obesity-related comorbidities, … |
MARGARETH MARTINO; | 2026-02-12 |
| 168 | Long-term Adaptations of Skeletal Muscle in Overweight and Obese Individuals After Hybrid Training PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with overweight or obesity, even in the absence of dietary intake manipulation. Hybrid type training represents a form of HIIT, that incorporates both cardiorespiratory and musculoskeletal stimuli, by combining multiple types of exercise into a circuit-type, interval style workout. Recent evidence suggests that long-term participation in hybrid HIIT results in significant health-related benefits. However, … |
IOANNIS G. FATOUROS; | 2026-01-14 |
| 169 | Microrandomized Trial to Optimize Use of Burden-reducing Self-monitoring Approaches in Behavioral Obesity Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial is focused on testing dietary self-monitoring strategies used in behavioral obesity treatment. The goal is to determine which self-monitoring strategies are most useful for whom, at which points in treatment, and under what circumstances. Researchers will provide a 24-week online behavioral obesity treatment program, and will randomize participants to use one of 5 dietary self-monitoring strategies every two weeks. The five strategies include: recording all food and drink consumed and corresponding energy intake (i.e., calories) on 7 days per week; recording all food and drink consumed and corresponding energy intake (i.e., calories) on 3 days per week; … |
GRAHAM THOMAS; | 2026-02-04 |
| 170 | Stanford Pediatric Healthy Weight Index PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will develop a simple index to measure how well the body uses insulin and overall heart and metabolic health in children and teens with obesity. The investigators will use data from wearable devices (like fitness trackers) and glucose monitors, along with lab tests, to learn how activity and glucose relate to metabolic problems. |
KARL SYLVESTER; | 2026-01-05 |
| 171 | A Phase 1 Randomised, Double-blind, Placebo-controlled Single Ascending and Multiple Ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SYNT-101 in Healthy Adults and Healthy Adults Who Are Overweight or Have Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A Phase 1, single-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacodynamics of single and multiple dose regimens of SYNT-101 in healthy and overweight adults. |
SYNTIS BIO | 2026-01-15 |
| 172 | Effect of High-intensity Interval Training on Cardiometabolic Health and Physical Fitness in Young Adults With Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of the present project is to compare the effects of two types of training on cardiovascular health components and physical fitness in young adults with obesity. |
JOSÉ MANUEL PÉREZ CASILLAS; | 2025-12-15 |
| 173 | Evaluation of The Correlation Between Body Roundness Index (BRI), Body Mass Index (BMI), and VIDAC Score in Obese Patients: A Prospective Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The VIDIAC score is a measurement system that objectively defines glottic visibility and anatomical complexity in videolaryngoscopy. The literature has shown a relationship between parameters such as BMI, NC, and TMD and difficult airway management in obese patients, but there is no study examining the BRI-VIDIAC relationship. |
SAMSUN UNIVERSITY | 2026-01-28 |
| 174 | A Randomized Controlled Trial of Laparoscopic Versus Open Surgery for Colon Cancer With Visceral Obesity PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to elucidate whether there is a difference in long-term prognosis between laparoscopic surgery and open surgery in colon cancer patients with visceral obesity. |
JUN LI; | 2026-01-02 |
| 175 | Assessing Obesity Related Risk Factors in Burke, Columbia, Richmond (BCR) Adult Population: A Genetic and Behavioral Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to explore the association between Melanocortin-4 Receptor (MC4R) polymorphisms, eating habits, and social determinants of health in a heterogeneous adult population in Georgia, USA. |
AUGUSTA UNIVERSITY | 2026-01-14 |
| 176 | Predicting Biological Therapy Effectiveness in Ulcerative Colitis Patients Using Intestinal Ultrasound and Visceral Fat Assessment: A Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Our study aimed to detecting biological therapy effectiveness in UC patients using visceral fat assessment |
AMIRA MOHAMMED ABDEL MOWGOD; | 2026-01-07 |
| 177 | Standard of Care or Weight Loss Drug Therapy in Obesity-related Hypertension – Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Hypertension is the leading risk factor for death globally, affecting approximately 30% of adults in the United Kingdom. Obesity is also a serious and ongoing epidemic, with global obesity rates having more than tripled in men and doubled in women, since 1975. In the United Kingdom, 64% of the adult population are overweight or obese. Hypertension and obesity share a well-established association, with obesity being responsible for the development of hypertension in 40-78% of cases. In young adults, … |
JAMES GOODMAN; | 2026-01-29 |
| 178 | Safety and Efficacy of Tirzepatide (Spartina) in Obese Kidney Transplant Recipients: A Pilot Study on Weight Loss, Gastrointestinal Tolerability, and Graft Function PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Post-transplant obesity is a common complication after kidney transplantation, largely attributed to recovery from uremia, increased appetite, sedentary lifestyle, and long-term corticosteroid exposure. Obesity in kidney transplant recipients increases the risk of cardiovascular disease, post-transplant diabetes mellitus (PTDM), and may contribute to graft injury through hyperfiltration-related mechanisms, potentially leading to reduced graft survival. Current approaches for weight management in transplant recipients, including lifestyle modification, are often insufficient, while bariatric surgery carries considerable risks and concerns regarding altered absorption of immunosuppressive medications. Tirzepatide (Iranian brand name: Spartina), the first dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, … |
NOOSHIN DALILI; | 2026-02-20 |
| 179 | Feasibility, Acceptability, and Preliminary Phase II Efficacy Testing of A Community-Informed Infant Obesity Prevention Program Addressing The Impact of Maternal Mental Health on Eating and Feeding PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Infants from low-income families are at increased risk for obesity, but obesity prevention programs tailored specifically to the needs of these infants are lacking. Our team developed Healthy Eating for My Infant (HEMI) to address the specific obesity risk factors, barriers to health behaviors, and needs articulated by community members and low-income families (e.g., maternal mental health, realistic feeding options within the context of food insecurity). The current study will examine the feasibility and acceptability of HEMI delivered via home visiting, as well as preliminary efficacy for improving infant growth trajectories, diet, … |
CATHY STOUGH; | 2025-12-16 |
| 180 | Effects of Tirzepatide on Skeletal Muscle in Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is evaluating whether a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, tirzepatide, can affect the function, structure and metabolism of skeletal muscles in adults with obesity. Participants, premenopausal females with obesity, will receive either tirzepatide or placebo over 24 weeks. Researchers will assess body weight, body composition, muscle strength and functional performance, neuromuscular function and will perform muscle biopsies before and after treatment to study molecular and histological changes following treatment. The goal of this study is to investigate the effects of tirzepatide on skeletal muscle function, quantity, … |
MOJCA JENSTERLE SEVER; | 2026-01-28 |
| 181 | Combine Effects of Senobi Exercise & Aerobic Exercises on Body Mass Index, Fatigue and Quality of Life in Polycystic Ovarian Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: One of the most prevalent endocrine system conditions affecting women of reproductive age is polycystic ovary syndrome (PCOS), also known as hyperandrogenic anovulation (HA) or Stein-Leventhal syndrome. This chronic and heterogeneous disorder manifests itself as menstrual dysfunction, infertility, hirsutism, acne, and obesity. This study will be randomized controlled trial and will be conducted in Qasim Sandhu medical complex, … |
WAJEEHA ZIA; | 2026-01-08 |
| 182 | Evaluating The Efficacy of High-Protein Diabetes Specific Formula (HP-DSF) on Body Composition in Overweight/Obese Patients With Type 2 Diabetes Treated With Incretin Mimetic Drugs PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A randomized clinical study to assess the efficacy of a high-protein diabetes specific formula (HPDSF) on lean muscle mass in overweight and obese patients with type 2 diabetes who are initiating treatment with incretin-mimetic drugs. |
OSAMA HAMDY; | 2026-01-30 |
| 183 | Sea Buckthorn Aqueous Infusion Impact on Body Composition Metrics Among Overweight Female Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: * A total of 60 overweight women (BMI 25-29.9 kg/m²), aged 18-50years, will be enrolled and randomized equally into intervention and control groups. The intervention group will consume a 5 g freshly prepared seabuckthorn aqueous infusion daily for 12 weeks, while controls maintain usual habits without supplementation. * The seabuckthorn aqueous infusion will be prepared by using 250mL of potable boiled water and then cooled to a lukewarm temperature (around 40-45°C). At this point, 5 g of seabuckthorn powder will be added, stirred thoroughly until fully dispersed, … |
QAISAR RAZA; | 2026-01-02 |
| 184 | Improving Lifestyle Habits and Metabolic Health in Forensic Psychiatric Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background:People in compulsory forensic psychiatric care experience high rates of metabolic syndrome, cardiovascular disease, and related lifestyle risk factors, yet structured preventive health interventions are uncommon in secure psychiatric settings. The Structured Health Dialogue (SHD), a Swedish primary care model for cardiovascular disease prevention, combines motivational interviewing with individualised risk assessment and tailored lifestyle advice. Objective:To evaluate the feasibility, acceptability, and preliminary effects of an adapted SHD intervention in forensic psychiatric inpatient care. Methods:This single-centre, parallel-group, … |
KRONOBERG COUNTY COUNCIL | 2025-12-04 |
| 185 | A Phase 3, Randomized, Active- and Placebo-Controlled, Partially-Blinded Study to Compare The Efficacy and Safety of KAI-9531 Administered Once Weekly Versus Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to demonstrate that KAI-9531 subcutaneous (SC) injection once weekly is superior to semaglutide SC once weekly and to placebo SC once weekly on percent change in body weight. |
KAILERA | 2026-03-13 |
| 186 | A Phase I, Randomized, Double-blind, Placebo-Controlled Study Evaluating The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LAE103 As Single and Multiple Ascending Doses in Healthy Overweight/Obese Participants, and As Single Dose in Healthy Postmenopausal Women, With An Additional Evaluation of Single Ascending Dose of LAE103 in Combination With LAE102 in Healthy Overweight/Obese Participants PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of LAE103 injection in healthy overweight/obese participants or healthy postmenopausal women. Study will also evaluate the safety, tolerability and preliminary pharmacodynamic effect of multiple dose injections in overweight/obese participants. In addition, the study will also investigate the safety, tolerability of a single-dose co-administration of LAE102 and LAE103 in healthy overweight/obese participants. |
MICHAEL WONG; | 2026-01-20 |
| 187 | Evaluating The Efficacy and Safety of MET097, A Fully-Biased, Ultra Long-Acting GLP-1RA, In People With Overweight or Obesity: A Phase 3, Multi-Center Randomized, Controlled Trial (VESPER-4) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks. |
METSERA A WHOLLY OWNED SUBSIDIARY OF PFIZER | 2026-02-17 |
| 188 | A Randomized, Double-blind, Placebo-controlled Phase 3 Clinical Trial to Assess The Efficacy and Safety of IBI362 in Chinese Adolescents With Obesity or Overweight（GLORY-YOUNG） PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study is designed to assess the efficacy and safety of multiple doses of IBI362 in Chinese adolescent subjects with obesity or overweight. It plans to enroll 180 adolescents (aged ≥12 and \<18 years) who have failed to achieve a 5 kg weight reduction after at least 12 weeks of dietary and exercise intervention. |
JUNFEN FU; | 2026-01-08 |
| 189 | A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALV-100 in Participants With Overweight or Obesity With or Without Type 2 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants with or without Type 2 Diabetes |
ALVEUS THERAPEUTICS | 2026-02-10 |
| 190 | Comparison of The Effects of Semaglutide and Tirzepatide Treatments in Combination With Exercise in Obesity Management PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Obesity is a growing global health problem that affects people of all ages. It can lead to serious health issues such as cardiovascular disease, insulin resistance, inflammation, and reduced physical function. New medications, including GLP-1 receptor agonists like semaglutide and dual GLP-1/GIP agonists like tirzepatide, have been shown to help people lose significant weight. However, some of this rapid weight loss may come from a reduction in muscle mass rather than fat. Losing muscle can lower physical performance, impair metabolic health, … |
SAFAK YIGIT; | 2026-01-06 |
| 191 | A Multicenter, Randomized, Open-label, Parallel-controlled Phase III Study Comparing The Efficacy and Safety of HRS9531 Injection Versus Semaglutide Injection in Subjects With Obesity PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multicenter, randomized, open-label, parallel-controlled, phase III study to compare the efficacy, safety, and tolerability of HRS9531 versus semaglutide once weekly (QW) in adult subjects with obesity |
FUJIAN SHENGDI PHARMACEUTICAL | 2026-02-27 |
| 192 | A Prospective Observational Study Comparing The El Ganzouri Risk Index and Airway Ultrasonography in Predicting Difficult Intubation in Patients Undergoing Bariatric Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed as a prospective observational study and will be conducted at the Health Sciences University Antalya Training and Research Hospital. Adult patients scheduled to undergo bariatric surgery will be included. The aim of this study is to compare the El Ganzouri Risk Index (EGRI) and airway ultrasonography (USG) parameters in predicting difficult intubation and to evaluate their relationship with the Cormack-Lehane (CL) score obtained during direct laryngoscopy. Before surgery, each participant will be evaluated using both the EGRI scoring system and airway USG. During general anesthesia, tracheal intubation will be performed using direct laryngoscopy, … |
ANTALYA TRAINING AND RESEARCH HOSPITAL | 2026-03-09 |
| 193 | A Comparison of Effectiveness, Safety, and Cost-effectiveness of Dapagliflozin and Empagliflozin in Patients With Type 2 Diabetes Mellitus and High Body Mass Index (BMI): A Randomized Controlled Trial at A Tertiary Care Hospital in Central India PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the effect of two drugs used to treat diabetes, that is, Dapagliflozin and Empagliflozin on HbA1c (which is an indicator of blood sugar over the last 3 months) body weight, liver and kidney function, blood pressure, and overall cost-effectiveness in patients with type 2 diabetes and high body mass index (23kg/m2). The results will help us determine which drug is more effective, safer, and economical for Indian patients and improve future treatment options. |
BHAVYA BHAVYA; | 2025-12-31 |
| 194 | A Single-Center, Single-Dose, Randomized, Open-Label, Single-Period, Parallel Bioequivalence Study of BGM0504 Injection in Overweight/Obese Participants PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a study to evaluate the bioequivalence of a single subcutaneous injection of BGM0504 multi-dose pen (experimental formula T1) and BGM0504 single-dose pen (experimental formula T2) with BGM0504 single-dose pen (reference formula R). |
BRIGHTGENE BIO MEDICAL TECHNOLOGY | 2026-02-03 |
| 195 | The Effect of Oral Iron Supplements on Insulin and Glucose Metabolism in Overweight and Obese Women PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study will be a randomized, double-blind, 17-day metabolic intervention trial including 14 days of high-dose or low-dose iron supplementation. A total of 70 overweight or obese (OW/OB) women will be enrolled. Participants will be individually randomized into either the high-iron or low-iron group. Women in the low-iron group will receive 15 mg of iron as ferrous fumarate daily for 14 days, while women in the high-iron group will receive 195 mg of iron as ferrous sulfate daily for 14 days. The study consists of three visits in total. On Day 0, … |
NICOLE STOFFEL; | 2026-01-02 |
| 196 | Longer-term Effects of High-dairy Food Patterns on The Gut-brain Axis in Adults With Overweight or Obesity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Disturbances in brain insulin sensitivity are associated not only with obesity and type 2 diabetes, but also with brain aging and cognitive decline. Longitudinal studies suggest that dietary patterns, particularly those high in dairy intake, may impact brain function via the gut-brain axis. Indeed, dairy foods are known to modulate gut microbiota and may, through this pathway, not only improve brain insulin sensitivity and cognitive performance, but also mental health and appetite regulation. However, underlying mechanisms remain largely unexplored. The primary objective of this study is to evaluate, in older adults with overweight or obesity, … |
RONALD P MENSINK; | 2026-01-21 |
| 197 | Association Between Food Intake-Related Brain Functional Patterns and Metabolic Profiles in Patients With Obesity: A Randomized Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a prospective, single-center, randomized, controlled, crossover intervention trial. A total of 60 participants, including 30 patients with obesity and 30 healthy controls, will be enrolled. Each participant will receive an isocaloric liquid meal challenge (glucose, fat, or protein) on three separate experimental days, with a washout period of at least 7 days between visits to eliminate carryover effects from the previous intervention. The primary objective is to investigate the association between brain functional patterns and plasma metabolic profiles following the ingestion of different macronutrients in patients with obesity, aiming to uncover potential neuro-metabolic imbalance features. |
YAN BI; | 2026-02-06 |
| 198 | Is There An Association Between Smartsphone Addiction, Obesity and Functional Capacity in Young Adults? PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: BACKGROUND: smartphone dependence causes adverse effects on one’s lifestyle such as dietary habits and daily routines, resulting in overweight or obesity. Additionally, academic stress also contributes to addictive behaviors, such as smartphone addiction. Research shows that problematic smartphone use is significantly associated with loneliness, low self-esteem, and depression. Poor mental health is also proven to be a risk factor for obesity in young adults. |
ALAA MOHAMED NAGUIB ASHRY; | 2026-01-09 |
| 199 | Effects of A Mediterranean Diet and Synbiotic Supplementation on Anthropometric and Biochemical Parameters and Quality of Life in Obese Women With Polycystic Ovary Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will look at whether a reduced-calorie Mediterranean-style eating plan, together with a synbiotic supplement, can improve health measures and quality of life in women who have polycystic ovary syndrome (PCOS) and are overweight or have obesity. Participants will be assigned by chance (like flipping a coin) to receive either the synbiotic supplement or a placebo (a look-alike product with no active ingredients). All participants will follow the same reduced-calorie Mediterranean diet for 8 weeks. The study team will measure body composition and weight-related measurements, … |
AYSENUR EMIRHUSEYINOGLU CALIK; | 2026-01-15 |
| 200 | A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate The Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy and Living With Overweight or Obesity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with obstructive sleep apnea (OSA) who are receiving positive airway pressure (PAP) therapy and are living with overweight or obesity. |
AMGEN | 2026-04-02 |