Clinical Digest: Recent Clinical Trials on Stroke (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Stroke. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Stroke (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Bicuspid Aortic Valve Replacement: EvaLuatIon of TranscathetEr VERsus Surgery (BELIEVERS) Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a multicenter, randomized superiority trial of standard of care therapies for severe aortic stenosis (AS) in patients with a bicuspid aortic valve (BAV). The two primary comparators in this study are: Transcatheter Aortic Valve Replacement (TAVR), and Surgical Aortic Valve Replacement (SAVR). TAVR is a minimally invasive transcatheter procedure to treat aortic valve disease.. SAVR is involving the open chest surgery to replace the aortic valve. The devices and international procedures in this Trial (TAVR or SAVR) are commercially approved by the FDA. Consented patients who are qualifying for the Trial will be randomized 1:1, … |
RAJ MAKKAR; | 2026-02-17 |
| 2 | Effectiveness of Real Home Settings Via Virtual Reality Task Oriented Training on Upper Llimb Function in Patients With Stroke: A Multicenter, Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke rank second among the top causes of death, affecting millions of people in the worldwide. It has been reported that hemiplegia is the most common sequelae after stroke, accounting for about 50%-70% of all sequelae of the disease. About 75% of stroke patients are accompanied by different degrees of upper limb dysfunction, … |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2026-04-02 |
| 3 | The Effect of Mobility Level in Stroke Patients on Anxiety, Depression, and Caregiver Burden in Caregivers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study was designed to determine the effect of functional mobility levels of stroke patients on caregiver burden, anxiety, and depression in their caregivers. |
SEDA NUR KEMER; | 2026-04-01 |
| 4 | Routine Use of Potassium Competitive Acid Blocker Versus Guideline-Directed Gastrointestinal Protection Strategy in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention on Dual Antiplatelet Therapy: A Randomized Trial PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the clinical outcomes between routine use of potassium competitive acid blocker (P-CAB) and guideline-directed gastrointestinal (GI) protection strategy in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) and being treated with dual antiplatelet therapy (DAPT). |
SAMSUNG MEDICAL CENTER | 2026-03-12 |
| 5 | Acupuncture Treatment for Post-Stroke Dysphagia: A Prospective, Multicenter Clinical Study of A Cohort-Based Embedded Partially Randomized Preference Trial PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Employing a nested design, a partially randomized preference study (Study II) is embedded within a prospective, multicenter cohort study (Study I). The cohort study, with acupuncture as the exposure factor, explores the clinical efficacy and health economic value of different integrated Chinese and Western medicine treatment protocols. The nested partially randomized preference study of different acupuncture protocols generates high-level evidence through randomized cohorts while supplementing real-world decision-making with preference cohort data. |
YUZHENG DU; | 2026-03-25 |
| 6 | Randomised Controlled Trial Comparing The Safety and EfficAcy of The Cocoon PFO Occluder Versus Amplatzer PFO ClosurE Device for Percutaneous Closure of Patent Foramen Ovale in Patients With A History of Stroke or Transient Ischemic Attack A Non-Profit, Single-blind, Investigator Driven Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a prospective, multicenter, randomized, controlled, single-blind, investigator-driven, non-profit clinical trial designed to compare the safety and efficacy of the Cocoon PFO Occluder with the Amplatzer PFO Occluder family in patients requiring percutaneous closure of a patent foramen ovale (PFO). Eligible participants are adults with a history of cryptogenic embolic stroke or neurologically confirmed transient ischemic attack (TIA) within the previous 12 months and a PFO suitable for transcatheter closure. A total of up to 1260 subjects will be enrolled across multiple European centers. Participants will be randomly assigned in a 3:1 ratio to receive either the Cocoon PFO Occluder (experimental group) or an Amplatzer PFO closure device (control group). The procedure will be performed as soon as possible after randomization, preferably within 14 days and no later than 45 days. The primary endpoint is a non-inferiority comparison of a composite outcome at 12 months, including recurrent ischemic stroke, TIA, or all-cause death. Secondary endpoints include PFO closure rate at 6 months, assessed by echocardiographic imaging, and other measures of safety, device performance, and clinical outcomes. The study is conducted in a single-blind fashion: patients will not be informed of the device they receive unless they explicitly request this information. Any patient who chooses to be unblinded will continue to participate without affecting eligibility or follow-up, and the date of unblinding will be documented to allow appropriate sensitivity analyses. This trial aims to provide robust comparative evidence on the clinical performance of the Cocoon PFO Occluder relative to the Amplatzer PFO Occluder to guide optimal device selection in patients with cryptogenic stroke or TIA associated with PFO. |
GIUSEPPE TARANTINI; | 2026-03-24 |
| 7 | Effect of Smartwatch Along With Foundation Model for The Monitoring and Management of Acute Myocardial Infarction Patients During Outpatient Cardiac Rehabilitation After Percutaneous Coronary Intervention: Protocol for A Randomised Controlled Multicentre Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized controlled trial is to evaluate whether a HUAWEI smartwatch integrated with a foundation model can enhance daily monitoring and management of AMI patients during outpatient cardiac rehabilitation after PCI. Can a HUAWEI smartwatch with a foundation model improve daily monitoring/management of post-PCI AMI patients during 3-month outpatient CR, … |
ZHANG CUNTAI; | 2026-02-09 |
| 8 | Randomized Trial to Evaluate The Efficacy and Safety of Very Low Dose Anticoagulant Therapy Added to Standard-Care Single Antiplatelet Therapy for Prevention of Recurrent Strokes in Patients With Ischemic Stroke Aged 75+ Years PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The overall aim of this research is to improve secondary stroke prevention for older patients with stroke. In current practice, patients with stroke are often prescribed antiplatelet therapy with either aspirin or clopidogrel to help prevent recurrent strokes. However, an antiplatelet medication may not be effective enough for some patients. A promising new treatment strategy to enhance stroke prevention involves a very low dose of an anticoagulant (anti-clotting medication) added to the standard antiplatelet therapy. In a previous study, this approach cut stroke risk in half among patients with heart/vascular disease, … |
SUNNYBROOK HEALTH SCIENCES CENTRE | 2026-03-06 |
| 9 | Ten-Year Outcomes of Randomized Comparison of Drug-eluting Stent Implantation Versus Optimal Medical Treatment in Patient With Chronic Total Occlusion: DECISION-CTO Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to compare long term efficacy of drug-eluting stent implantation compare to optimal medical treatment in patient with chronic total occlusion in a very long-term follow-up (minimum 10 years) period. |
SEUNG-JUNG PARK; | 2025-12-29 |
| 10 | Semaglutide for Reducing Cardiovascular Events in Patients Undergoing Transcatether Aortic Valve Replacement PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase III, randomized, double-blind, placebo-controlled, multicenter clinical trial evaluating the safety and efficacy of once-weekly semaglutide 2.4 mg in adult patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS) who meet current clinical criteria for semaglutide treatment. A total of 826 participants will be randomized 1:1 to receive semaglutide or placebo as an add-on to standard-of-care, starting 3 months before TAVR and continuing for 24 months post-procedure. The primary endpoint is time to first occurrence of a composite of cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke or transient ischemic accident (TIA), … |
NINA AJMONE MARSAN; | 2025-07-29 |
| 11 | Safety and Efficacy of Immediate Abundant Intravenous Normal Saline Infusion for Stroke After Intravenous Thrombolysis: A Multi-centre Randomized Controlled Phase III Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The intravenous administration of abundant normal saline is an easy-to-use strategy commonly employed to expand the blood volume. This study aimed to evaluate the efficacy and safety of the early administration of an abundant normal saline infusion after intravenous thrombolysis for promoting functional independence in patients with acute ischemic stroke. This multicenter, randomized, phase III clinical trial intends to enroll stroke participants who have undergone intravenous thrombolysis. Eligible patients are randomized to receive either abundant intravenous normal saline infusion (2,000-2,500 mL; normal saline group) or a small volume of intravenous normal saline infusion (≤600 mL; … |
JIAYUE DING; | 2026-03-27 |
| 12 | Comparison of General Anesthesia and Sedoanalgesia on Mortality and Neurological Outcomes in Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This retrospective cohort study examined clinical outcomes in patients who underwent mechanical thrombectomy for acute ischemic stroke under general anesthesia or sedoanalgesia. Patient data from 2014 to 2018 were obtained from hospital medical records. Mortality and neurological outcomes were compared between anesthesia groups. |
FATMA ACIL; | 2026-04-03 |
| 13 | Individual Vs Co-Treatment in Acute Stroke Rehabilitation and Evaluation PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single center, pragmatic, randomized trial comparing the effectiveness of two commonly used approaches (co-treatment and individual treatment) in acute care rehabilitation. |
SARAH WELCH; | 2026-02-17 |
| 14 | Data-driven Intervention to Reduce Pre-discharge Fall Risk After Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: After stroke, falling is a common problem. Falls can lead to injury, as well as fear of future falls. It is important to try to prevent falls from happening after stroke. To goal of this study is to test a new treatment to try to prevent falls after stroke. The people in the study will be patients who are in the hospital receiving care after a stroke. While they are in the hospital, … |
PRUDENCE PLUMMER; | 2026-02-27 |
| 15 | Non Invasive Hemodynamic Assessment of Cardiac Output and Stroke Volume in Septic Shock Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this research is to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring cardiac output and stroke volume in patients with septic shock, to evaluate the potential of EC as a non-invasive alternative for hemodynamic monitoring. |
OSMAN MOHAMED OSMAN KHALAF; | 2026-01-07 |
| 16 | Robot-Assisted Minimally Invasive Surgery for Brainstem Hemorrhage PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this clinical trial is to observe the improvements in clinical symptoms and imaging outcomes for brainstem hemorrhage using robot-assisted stereotactic puncture, evaluate the clinical efficacy and safety of this treatment, and explore the development of a high-precision, intelligent, and individualized microsurgical diagnosis and treatment process for brainstem hemorrhage. The main questions it aims to address are: * Establish a multi-center clinical database for brainstem hemorrhage. * Clinically observe and evaluate the intervention effects of robot-assisted stereotactic puncture on brainstem hemorrhage, compare it with the traditional conservative treatment control group, … |
YANBING YU; | 2026-02-12 |
| 17 | Evaluation of The Support Program to Enhance Self-management Capacity Among Stroke Survivors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this interventional study is to develop and evaluate a post-stroke patient support program aimed at enhancing patients’ ability to self-management after discharge to home. The main question it aim to answer are: After participating in the support program, do patients show improvements in stroke-related knowledge, independence in activities of daily living, … |
PHAM NGOC THACH UNIVERSITY OF MEDICINE | 2026-03-12 |
| 18 | Behavioral Activation for The PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors (LIVE-WEL) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The overall objective of the project is to determine the effectiveness of tele-delivered behavioral activation (BA) by trained lay counselors (Tele-BA-S) to prevent Post-stroke depression (PSD) in low-income, older stroke survivors with subthreshold depression (SD). |
JENNIFER BEAUCHAMP; | 2026-03-17 |
| 19 | Endovascular Recanalization Versus Aggressive Medical Management Alone for Symptomatic Non-Acute Intracranial Artery Occlusion: A Multicenter, Prospective, Open-Label, Endpoint-Blinded, Randomized Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A multicenter, randomized, open-label, endpoint-blinded trial to compare the effects of endovascular recanalization plus aggressive medical management with aggressive medical management alone on stroke recurrence and mortality in patients with symptomatic non-acute intracranial artery occlusion. |
FENG GAO; | 2026-03-27 |
| 20 | Reaching The Unreached: Randomized Trial of Home-Based Telerehabilitation for Stroke Without Outpatient Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: After a stroke, many people have trouble using their arms and hands. This can make daily tasks-like eating, dressing, or writing-very hard. In Alberta, especially in small towns and rural areas, many stroke survivors go home from the hospital without being referred to rehabilitation. As a result, … |
JESSICA M D’AMICO; | 2026-03-12 |
| 21 | Intravenous Tenecteplase for Acute Ischemic Stroke With Unknown Time of Onset Under Non-Contrast CT Selection: A Multicenter, Prospective, Randomized, Open-label, Blinded Endpoint Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The benefit of intravenous tenecteplase for acute ischemic stroke with unknown time of onset, e.g. wake-up stroke, remains uncertain. This randomized study aims to assess the efficacy and safety of intravenous tenecteplase following non-contrast CT screening for acute ischemic stroke with unknown time of onset. |
YUAN WU; | 2026-03-17 |
| 22 | Effect of E-learning Training on National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) Assessment Performance: A Web-based Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this web-based randomized clinical trial is to evaluate whether an e-learning training program improves the accuracy of National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) assessments among practicing paramedics in French-speaking Switzerland who have not previously received formal training in these scales. The main questions it aims to answer are: * Does e-learning training improve performance on a standardized NIHSS assessment quiz compared with no prior training? * Does e-learning training improve the accuracy of mRS assessment using case-based clinical vignettes compared with no prior training? Researchers will compare paramedics who complete the NIHSS and mRS e-learning modules before assessment (intervention group) with paramedics who complete the assessments without prior training (control group) to determine whether e-learning training leads to higher assessment performance scores. Participants will: * Provide electronic informed consent via a secure web-based platform * Be randomly assigned to either the intervention group or the control group * Complete either the e-learning modules before assessment or the assessments before training, depending on group allocation * Complete an online NIHSS quiz and mRS case-based vignettes * Receive access to the NIHSS and mRS e-learning modules by the end of the study |
STUBY LORIC; | 2026-01-07 |
| 23 | A Multicenter, Prospective, Observational, Real-World Registry Study of Intravenous Tenecteplase in Very Old Patients With Acute Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The benefit of intravenous tenecteplase in very old patients with acute ischemic stroke (AIS) remain uncertain. This real-world study aims to evaluate the effectiveness and safety of intravenous tenecteplase in AIS patients aged 80 years or older within 4.5 hours of symptom onset. |
YUAN WU; | 2026-03-17 |
| 24 | Delayed Versus Early Antihyperglycemic Treatment for Severe Stroke: A Prospective, Randomized, Controlled, Open-Label, Blinded-Endpoint Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a exploratory, randomized, controlled, open-label, blinded-endpoint Phase II clinical trial designed to evaluate whether delaying antihyperglycemic treatment for 72 hours improves neurological outcomes in patients with severe stroke and hyperglycemia. A total of 426 patients with severe stroke (including ischemic stroke, intracerebral hemorrhage, … |
JIE XU; | 2026-03-30 |
| 25 | Comparison of Speaking Valve Trial and Capping Trial in The Decannulation Process for Stroke Patients: A Randomized, Controlled, Multicenter Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the efficacy and safety of the Speaking Valve trial versus the traditional Capping trial as indicators for tracheostomy decannulation in stroke patients. The trial is a prospective, multicenter, randomized, parallel-group, outcomes-assessor-blinded study with an exploratory crossover design. |
HONGYING JIANG; | 2026-02-27 |
| 26 | Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis Before and After Functional Electrical Stimulation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking. The L300 device is designed to help lift the foot during each step. This study will evaluate how using the L300 affects walking performance. Researchers will measure walking speed, step length, … |
EMILY ROSARIO; | 2026-03-27 |
| 27 | Interoception and Emotional Recovery After Stroke: A Pilot Study of Mindfulness-Based Stress Reduction PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pilot study is to examine the feasibility, acceptability, and preliminary effects of mindfulness-based stress reduction (MBSR) on interoception (your understanding of your body’s internal senses), emotional well-being, and whole person health. A total of 30 people with chronic stroke will be enrolled in this study to participate in an MBSR course, consisting of a 30-minute intake visit, 8 sessions lasting 2.5 hours plus a 1-day 7-hour retreat. Participants will be randomized into either the first MBSR course (immediate start) or the second MBSR course (delayed start/waitlist control). |
AMANDA HERRMANN; | 2026-04-03 |
| 28 | A Randomized Controlled Trial Assessing The Efficacy, Feasibility, and Usability of An Exergame-Based Semi-Autonomous Upper-Limb Rehabilitation Program in Individuals With Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a randomized controlled trial designed to evaluate the effectiveness of a semi-autonomous upper-limb rehabilitation program based on exergames in adults with chronic stroke. Participants will be randomly assigned (1:1) to either an exergame-based intervention or an individually delivered conventional home-based therapy program. The primary outcome is upper-limb functionality as measured by the Action Research Arm Test (ARAT). Secondary outcomes include upper-limb motor function and quality of life. The study also examines adherence, usability, and the feasibility of remote monitoring for long-term implementation. |
MARINA CASTEL SÁNCHEZ; | 2026-02-20 |
| 29 | Evaluation of The Effectiveness of A Personalized Music-Based Aerobic Exercise Rehabilitation Program for Patients With Subacute Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effectiveness of a personalized music-based aerobic exercise program designed specifically for inpatients in the subacute phase of stroke. All participants will receive the hospital’s standard physical therapy program. In addition, the intervention group will participate in 30-minute music-based aerobic exercise sessions, 5 days per week, for a total of 6 weeks. The aerobic exercises are gentle and adapted to the functional abilities of individuals with subacute stroke. The exercises incorporate rhythmic music to guide movements of the arms, legs, and trunk, with the goal of improving mobility, balance, … |
TRỊNH MINH TÚ; | 2026-03-31 |
| 30 | YOGA-FIT: Protocol for A Crossover Trial Investigating The Feasibility and Impact of Yoga for People With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this mixed-methods pilot crossover study is to determine the feasibility (participant satisfaction, recruitment rate, participant and assessor burden, adherence, equipment and technology issues, and safety) of virtual and in-person LYB yoga for adult people with lived experience of stroke in Nova Scotia who are at least three months post stroke. The secondary objective is to estimate the efficacy of virtual and in-person yoga for improving balance, walking, mobility, mental health (anxiety and depression), and other health outcomes (pain, sleep, health perception, and falls). The tertiary objective is to estimate the extent to which cognitive function, fatigue, … |
ADRIA QUIGLEY; | 2026-03-12 |
| 31 | Effect of Functional Electrical Stimulation on Hand Functions in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Hand dysfunction is one of the most disabling consequences of stroke and significantly limits independence in activities of daily living. Recovery of fine hand function remains incomplete in many patients despite conventional rehabilitation. By facilitating muscle activation and promoting neuroplasticity, Functional electrical stimulation (FES) has emerged as a promising intervention to enhance motor recovery. Objective: To investigate the effect of functional electrical stimulation on hand function in patients with subacute stroke. |
MOSTAFA SHATRA; | 2026-03-09 |
| 32 | Application of Digital Twins’ Technology in Patients Who Had A Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During The Secondary Prevention Phase: A Proof of Concept Using A Randomized Control Trial (Clinical Study 6, STRATIF-AI Project) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to obtain initial feedback on the implementation of the STRATIF-AI platform and digital twin in the secondary prevention phase in patients with stroke, Moyamoya disease and Cerebral amyloid angiopathy, including adults of both sexes. The main questions it aims to answer is: how is the patients’ experience regarding the use of the STRATIF-AI platform? Researchers will compare Arm 1, who use the STRATIF-AI app in addition to standard secondary prevention, against Arm 2, who receive standard secondary prevention only, … |
FONDAZIONE I R C C S ISTITUTO NEUROLOGICO CARLO BESTA | 2026-03-30 |
| 33 | Safely Quenching Complement in Stroke Subjects: A Phase 1 Safety Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain. All patients in the study must have already had a treatment called a thrombectomy, … |
E. SANDER CONNOLLY; | 2026-03-27 |
| 34 | Effects of Vestibular Training on Community Ambulation and Fall Risk in Individuals With Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Nearly half of individuals with stroke experience limitations in community ambulation, and 35.7% of community-dwelling stroke survivors experienced falls while walking, indicating that falls are common during routine daily activities in community settings. Sensory reweighting refers to the ability to appropriately prioritize and integrate sensory inputs to maintain postural stability. Stroke survivors often demonstrate impaired sensory reweighting, characterized by excessive reliance on visual and proprioceptive cues and insufficient integration of vestibular information. This deficit adversely affects postural control and subsequently compromises gait performance and fall risk .In addition, many individuals with stroke exhibit reduced gaze stability during walking and turning, … |
YEA-RU YANG; | 2026-03-27 |
| 35 | Left Atrial Appendage Closure and Pulsed Field Ablation Procedure Versus Left Atrial Appendage Closure Alone in Persistent Atrial Fibrillation Patients With Mild Symptoms and High Risk of Stroke: A Prospective, Multicenter, Single-Blind, Randomized Controlled Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a prospective, multicenter, single-blinded, randomized controlled trial to investigate whether concomitant left atrial appendage closure (LAAC) and pulsed field ablation (PFA) is more effective than LAAC alone in improving the outcomes in persistent atrial fibrillation (AF) patients with high risk of stroke. Emerging data show that some-especially those with persistent AF, high AF burden, … |
CHENYANG JIANG; | 2026-03-24 |
| 36 | Predictive Utility of Monocyte-to-Albumin Neutrophil to Albumin and Total Leukocytic Count-to-Albumin Ratios in Ischemic Stroke. A Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Acute Ischemic Stroke is a leading cause of mortality and long-term disability worldwide. Increasing evidence suggests that systemic inflammation plays a significant role in the pathophysiology and progression of ischemic brain injury. Recently, several inflammatory biomarkers derived from routine laboratory tests have been investigated as potential predictors of stroke severity and clinical outcome. This prospective cohort study aims to evaluate the predictive utility of the monocyte-to-albumin ratio, neutrophil-to-albumin ratio, … |
MOHAMED MOUNIR ABBAS; | 2026-03-17 |
| 37 | A Pilot Evaluation of The Effectiveness and Economic Impact of A Multi-Technology Rehabilitation Programme for Sub-acute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Biomedical Engineering Dept, University of Strathclyde, co-creates rehabilitation technology. In 2023-2024 a clinical study (NCT06787768) was conducted to understand the feasibility of a multi-technology approach to rehabilitation early after stroke. This was successful and leads to the next phase which is to gather preliminary evidence of the effectiveness of this approach by monitoring change in the mobility of patients who receive this intervention compared with usual care which will be gathered through a data linkage project (tracking the outcomes from matched patients from other parts of Scotland who receive usual care). |
GILLIAN SWEENEY; | 2026-01-22 |
| 38 | Exercise Induced Hypoalgesia in Pain-free Stroke and Healthy Populations: A Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Exercise has shown multiple beneficial effects in both healthy and post-stroke populations. One of these is the acute reduction in sensitivity to painful stimuli, called exercise-induced hypoalgesia (EIH). This phenomenon has been studied since 1979 and has shown improvements in pain thresholds with both aerobic and resistance training in healthy, pain-free populations and different chronic pain conditions. Although there has been extensive research on EIH in healthy populations and those with chronic musculoskeletal pain, surprisingly little attention has been given to individuals with neurological pathologies. Chronic pain is found in more than 50% of patients after stroke, … |
ALEJANDRO HERRERA ROJAS; | 2026-03-20 |
| 39 | The Effect of Upper Extremity Support Usage on Spatiotemporal Gait Parameters in Individuals With Stroke: A Prospective Cross-over Experimental Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose: The primary goal of this study is to investigate how different levels of upper extremity (arm) support affect walking patterns in individuals who have experienced a stroke. Specifically, the research aims to determine how restricting or facilitating arm swing during walking modulates spatiotemporal gait parameters (such as speed, step length, and rhythm). Background: Arm swing plays a crucial role in maintaining balance, stability, and energy efficiency during normal walking. Following a stroke, … |
MURAT AKINCI; | 2026-03-27 |
| 40 | The Mechatronic Remote Physiotherapy System (MRPS) in Remote Stroke Rehabilitation: A Pilot Controlled Trial for ‘Early Supported Discharge’ PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this pilot trial is to examine and compare the safety and feasibility of enhanced Early Supported Discharge (ESD) through the Mechatronic Remote Physiotherapy System (MRPS) and traditional ESD after stroke. The main questions this trial aims to answer are: * Is enhanced ESD via the MRPS safe, … |
KENNETH MONAGHAN; | 2025-05-14 |
| 41 | Individual Alpha Frequency-Based RTMS for Post-Stroke Motor Recovery: Efficacy and Neurophysiological Mechanisms PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the efficacy of a personalized brain stimulation technique, Individual Alpha Frequency (IAF)-based rTMS, for motor function recovery in adult patients with a first-ever ischemic stroke. The main questions it aims to answer are: 1. Does IAF-based rTMS improve upper and lower limb motor recovery better than a sham (placebo) stimulation? 2. How does this personalized stimulation affect brain wave activity (cortical oscillatory dynamics) as measured by EEG? Researchers will compare active IAF-based rTMS with a sham stimulation control in a crossover design to see if the active treatment leads to better clinical motor outcomes and beneficial changes in brain activity. Participants will: 1. Be randomly assigned to one of two sequences: receiving two weeks of active IAF-rTMS followed by two weeks of sham stimulation, or vice versa. 2. Attend 30-minute brain stimulation sessions, targeted at the motor cortex, 5 days a week for a total of 4 weeks. 3. Undergo clinical motor function assessments (including NIHSS, FMA-UE, and FMA-LE) and EEG recordings at three time points: at baseline, after 2 weeks, and at the end of the 4-week study. |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2026-03-27 |
| 42 | Immediate Effects of PETTLEP-Based AOMI on Upper Limb Kinematics in Stroke Survivors: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate the immediate effects of a mental practice technique, called PETTLEP-based Action Observation and Motor Imagery (AOMI), on arm movement in stroke survivors. Stroke often causes difficulty in moving the arm smoothly, leading patients to compensate by using their back or shoulder. In this study, … |
ABDELRAHMAN SABEE; | 2026-04-02 |
| 43 | Motivation-Induced Movement Therapy: Enhancing Upper Limb Engagement in Stroke Survivors Through Ring Sensors and Data Visualization PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if wearable sensor data visualization on smartphones can improve the use of the stroke-affected limb during everyday activities. Chronic stroke survivors (\>12 months from onset) ages 18-80 years old with residual upper extremity motor impairments may be eligible to participate. The main question it aims to answer is: Does the mobile health (mHealth) intervention help to improve the use of the stroke-affected upper-limb during daily living? The study is designed so each participant serves as their own control. Researchers will compare information from the baseline, intervention, … |
PAOLO BONATO; | 2026-03-31 |
| 44 | A First-in-Man (FIM) Study of The LAmbre™ II Left Atrial Appendage Occluder and Occluder Delivery System for Patients With Non-Valvular Atrial Fibrillation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Worldwide, atrial fibrillation (AF) is the most common cardiac arrhythmia in adults. The prevalence of AF gradually increases with age; its prevalence is 0.5% \~ 0.8% among 45 \~ 59 year-olds, 1.8% \~ 5.9% among 60 \~ 69 year-olds, and 6.7% \~17.9% among \> 79 year-olds. Thromboembolic complications are the leading cause of death and disability in patients with AF, with ischemic stroke being the most common complication. AF significantly increases the risk of stroke by 3- … |
SO CHAK YU KENT; | 2026-03-06 |
| 45 | Reliability of Community Ambulation Assessments, Taiwan Chinese Version of Falls Efficacy Scale, and Dynamic Visual Acuity Test in Individuals With Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Nearly half of individuals with stroke experience limitations in community ambulation, and 35.7% of community-dwelling stroke survivors experienced falls while walking, indicating that falls are common during routine daily activities in community settings. Patla (1999) proposed that community mobility is influenced by eight factors: ambient conditions, terrain characteristics, external physical load, attentional demands, postural transitions, traffic level, time constraints, and walking distance. This framework suggests that community ambulation requires consideration of multiple physiological domains as well as environmental factors. However, current assessments of community ambulation primarily rely on indoor walking speed as an indicator, … |
YEA-RU YANG; | 2026-03-27 |
| 46 | The Effect of Dual Task-Oriented Circuit Training on Neuroplasticity and Walking Adaptability in Subacute Stroke Patients: A Pilot and Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This pilot study aims to assess the feasibility, safety, and initial efficacy of an integrated Dual Task-Oriented Circuit Training (DTOCT) program for individuals in the subacute phase of stroke recovery. Although numerous patients recover the capacity to walk in a regulated hospital environment, they frequently encounter difficulties with community ambulation, the capability to traverse real-world settings while multitasking (e.g., walking while conversing or circumventing barriers). This study will examine if the integration of high-intensity circuit training with cognitive difficulties can promote neuroplasticity and enhance the patient’s capacity to safely traverse intricate daily settings. |
FARIDA ARISANTI; | 2026-03-27 |
| 47 | Clinical Evaluation of Continuous Dual Aspiration Technique With Zoom System for Stroke (ADAPT 2.0) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed to evaluate the effectiveness, safety and clinical performance of ADAPT 2.0, first-line aspiration neurothrombectomy with Zoom System with Continuous Dual Aspiration Technique (CDAT). |
DAVID FIORELLA; | 2026-04-01 |
| 48 | Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Direct Transfer to Angiography Suite (DTAS) for Patients With Suspected Large Vessel Occlusion PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators initiated a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) controlled trial to evaluate the efficacy and safety of the direct transfer to angiography suite (DTAS) triage strategy compared to the conventional triage strategy with CT/MRI in patients with suspected large artery occlusive (LVO) within 6 hours of symptom onset. |
YUNYUN XIONG; | 2026-03-12 |
| 49 | EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option. Many of the studies performed using tDCS have focused on improvements noted in hemiplegia as compared to aphasia, which is an equally disabling outcome of strokes. The results of these studies have not been conclusive and concordant with each other. In aphasia management, the majority of the studies have focused on chronic strokes. Since the use of tDCS is relatively new, … |
ASHISH KUMAR DUGGAL; | 2026-03-27 |
| 50 | Safety & Performance of The World Medica World Diverter Embolization Device PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to investgiate the safety and clinical performance of the World Diverter Emoblization Device for the endovascular treatment of wide-neck (neck width ≥ 4 mm or dome-to-neck ratio \<2) or fusiform intracranial aneurysms in the internal carotid artery (ICA) from the petrous segment to the terminus arising from a parent vessel with a diameter ≥ 2.5 mm and ≤ 5.5 mm. |
ALEJANDRO TOMASELLO; | 2026-01-14 |
| 51 | Comparison Of Tele-Rehabilitation Versus Conventional Rehabilitation To Improve Cognition Among Stroke Survivor PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to: * Compare tele-rehabilitation and conventional rehabilitation for cognitive improvement after stroke. * Evaluate changes in cognitive function using standardized assessment tools. * Determine whether tele-rehabilitation is as effective as conventional therapy. * Improve evidence-based rehabilitation strategies for stroke survivors. |
IMRAN AMJAD; | 2026-04-03 |
| 52 | CSP #2037T – Veterans Affairs Learning Health System Initiative to Assess Novel Screening Vs. Usual Care and Treatment With Apixaban Vs. Rivaroxaban in Veterans With Atrial Fibrillation (VALIANT-AF-T) Trial PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: * The trial will compare two anticoagulants (blood thinners) that are currently used in the VA and are considered standard care to prevent strokes in patients with atrial fibrillation. The two most commonly-used anticoagulants will be compared: apixaban (Eliquis) and rivaroxaban (Xarelto). They are considered by many doctors to have similar benefits and risks, but no one knows for sure. * The trial only enrolls patients with a diagnosis of atrial fibrillation (A Fib). * The investigators will measure, in about 10,000 VA patients nationally, whether the rates of stroke, major bleeding, … |
VA OFFICE OF RESEARCH AND DEVELOPMENT | 2026-02-09 |
| 53 | Safety and Efficacy Study of Intravenous Administration of MiSaver (Umbilical Cord Blood Derived Nucleated Cells) After Acute Myocardial Infarction PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This trial is a Phase II, multicenter clinical study. The purpose of this trial is to evaluate the safety and efficacy of MiSaver, a cellular therapy product, in patients who have experienced an acute myocardial infarction (AMI). Specifically, the study aims to assess the improvement in left ventricular function of the heart following the administration of MiSaver, as well as to determine the safety of using stem cell therapy in these patients. This trial will employ a single-blind design (subject-blinded), meaning that the participants will not be aware of whether they are receiving MiSaver or standard treatment, … |
HONYA MEDICAL | 2026-03-11 |
| 54 | Implantable Brain-Computer Interface for Upper-Limb Recovery After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The clinical investigation will take place in three phases: * A pre-selection/selection phase to ensure that the patient (lesion, symptoms, ability of our tools to detect your movement intentions, etc.) is suitable for a six-month intensive rehabilitation program using Brain-Machine Interface. * A second phase, consisting of implementing the intensive rehabilitation program, first in the traditional manner, without the Brain-Machine Interface (2 to 5 weeks), then, after implantation, with the Brain-Machine Interface (6 months). * During the third phase, … |
UNIVERSITY HOSPITAL GRENOBLE | 2026-03-17 |
| 55 | Neuralert Stroke Monitor Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The Neuralert monitoring system, a non-invasive device worn on each wrist, is designed to provide continuous monitoring and expedited recognition of stroke by identifying asymmetry in the extremities, facilitating patient treatment and improving outcomes. This study is designed to evaluate the safety and effectiveness of the Neuralert Monitor. This study aims to show that the device produces fewer than 2 false alarms per patient per day on average, and that the device detects stroke with a sensitivity significantly greater than a device producing 2 random alerts per day. |
NEURALERT TECHNOLOGIES | 2026-04-01 |
| 56 | The Effect of Repetitive Transcranial Magnetic Stimulation on Cardiac Autonomic Dysfunction in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) added to conventional neurological rehabilitation on heart rate variability (HRV), quality of life, upper extremity muscle strength and autonomic symptoms in patients with stroke. |
NURAN EYVAZ; | 2026-03-27 |
| 57 | Telemedicine-based Integrated Management of Atrial Fibrillation and Heart Failure in Older Patients in Village Clinics: The MIRACLE-AF II Cluster Randomized Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this cluster-randomized clinical trial is to evaluate a telemedicine-based, village doctor-led integrated management program for older adults (aged 65-80 years) who have both atrial fibrillation (AF) and heart failure (HF) in rural clinics in China. It aims to answer whether the digitally-supported program improves heart failure prognosis, assessed by the MAGGIC score, at 12 months , and reduces the risk of composite endpoint events, such as cardiovascular death, stroke, or heart failure hospitalization, over 36 months compared to conventional routine care. In this study, … |
MING CHU; | 2026-03-25 |
| 58 | Repeated Intravenous Thrombolysis for Ischemic Stroke Within 3.0 Hours of Onset With Tenecteplase (RITIS-TNK): A Prospective, Randomized, Open Label, Blinded Assessment of Outcome, and Multi-center Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Despite being the standard pharmacological reperfusion therapy for acute ischemic stroke, intravenous thrombolysis is limited by suboptimal recanalization rates. Tenecteplase (TNK), a newer thrombolytic agent, offers practical advantages over alteplase, including single bolus administration. However, a significant proportion of patients fail to achieve early clinical improvement after standard thrombolysis, … |
HUI-SHENG CHEN; | 2026-04-01 |
| 59 | Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours of Onset With Tenecteplase (RITIS-TNK2): A Prospective, Randomized, Open Label, Blinded Assessment of Outcome, and Multi-center Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: While intravenous thrombolysis (IVT) within 4.5 hours is the standard medical reperfusion therapy, its efficacy is limited, particularly for large or medium vessel occlusions (LVO/MeVO), with low recanalization rates for IVT with rt-PA. The newer thrombolytic agent, tenecteplase (TNK), offers practical advantages-including single bolus administration, a longer half-life, and potentially higher fibrin specificity-and has been shown to be non-inferior to rt-PA. Despite advances, a significant proportion of patients with LVO/MeVO do not achieve early clinical improvement after standard IVT, likely due to persistent occlusion from a high thrombus burden. Endovascular therapy, while highly effective for LVO, has limited accessibility. Therefore, … |
HUI-SHENG CHEN; | 2026-04-01 |
| 60 | Ambulatory Stroke Unit Treatment for Elderly Patients: A Prospective, Randomized, Controlled, Exploratory Non-Inferiority Trial (ARTIFICE) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in patients aged 60 years or older with acute ischemic stroke, transient ischemic attack (TIA), or retinal ischemia and non-disabling neurological deficits. Eligible patients are randomized 1:1 to same-day comprehensive ambulatory multiprofessional stroke evaluation (aSU) or guideline-based inpatient stroke unit treatment (SU). The primary endpoint is favorable functional outcome at 90 days, … |
JAN CHRISTOPH PURRUCKER; | 2026-03-31 |
| 61 | Efficacy and Safety of Intra-arterial Tenecteplase in Acute Ischemic Stroke Patients With Medium Vessel Occlusion Stroke (DATE-MeVO): A Multicenter, Prospective, Randomized Controlled, Open-label, Blinded-Endpoint Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: DATE-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of tenecteplase combined with standard medications in acute ischemic stroke patients with medium vessel occlusion stroke within 24 hours of onset. |
ZHENHUA ZHOU; | 2026-03-20 |
| 62 | Investigation of The Relationship Between Motor Imagery Skill and Neglect Level, Upper Extremity Motor Function, Activities of Daily Living, and Quality of Life in Individuals After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the relationship between motor imagery skills and neglect level, upper extremity motor function, activities of daily living, quality of life, lateralization performance, and mental timer performance in individuals with stroke. Individuals with stroke who meet the inclusion criteria and voluntarily agree to participate will be evaluated. Demographic and clinical information of the participants will be recorded on an assessment form prepared by the researcher. Upper extremity motor functions will be assessed using the Fugl-Meyer Upper Extremity Motor Assessment Scale and the Wolf Motor Function Test; … |
HAVVA ADLI; | 2026-03-27 |
| 63 | An Observational Study of Oral and Salivary Biomarkers Associated With Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims to explore the association between oral and salivary biomarkers and stroke. The study will include adult participants diagnosed with stroke and will analyze clinical, oral, and salivary parameters. The objective is to improve understanding of potential links between oral health, salivary biomarkers, and cerebrovascular disease. No experimental intervention will be performed. |
ABDELDJALIL ZITOUNI; | 2026-02-05 |
| 64 | A Phase II, Randomized, Placebo-Controlled, Double-Blind, Adaptive Study to Assess The Safety and Efficacy of Intravenous J147 Combined With Endovascular Therapy in Patients With Acute Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to find out if the drug J147 improves outcomes for persons who have had an ischemic stroke. It also will learn about the safety of J147 when given by injection to stroke patients. Researchers will compare the outcomes of those who receive J147 after therapy to clear the blood clot to those who don’t receive J147. Participants will be asked to undergo a series of three to four magnetic resonance imaging (MRI) brain scans, … |
STEVEN J WARACH; | 2026-02-24 |
| 65 | Randomized Multi-center Clinical Trial to Assess Effectiveness and Safety of Tirofiban Versus Intravenous Aspirin in Patients With Acute Ischemic Stroke Secondary to Tandem Injury, Subject to Recanalization Therapy Through Endovascular Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Patients with tandem lesions (TL) are defined as patients with an acute ischemic stroke (AIS) with occlusion of an intracranial vessel of the anterior circulation and an occlusion or severe stenosis (70-99%) of the origin of the ipsilateral internal carotid artery (ICA). The greatest current limitation in the management of this type of lesion is the use of antithrombotic medication (double antiaggregation) in the acute phase that is required in case of placing extracranial stent to stabilize the atheroma plaque. In relation to this antiplatelet regimen, … |
ELENA ZAPATA-ARRIZADA; | 2026-04-03 |
| 66 | A Master Protocol for A Phase 3, Randomized, Multicenter, Double-blind Study to Assess Stroke and Systemic Embolism Prevention With REGN7508 and REGN9933, Monoclonal Antibodies Against Factor XI, Versus Placebo in Participants With Atrial Fibrillation for Whom Oral Anticoagulation Is Unsuitable (ROXI-INCLINE) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study is researching 2 different experimental drugs called REGN7508 and REGN9933 (called study drugs). The study is focused on people who have atrial fibrillation, which means that the heart beats too fast and unevenly. When this happens, blood cannot move smoothly through the heart; it can slow down or pool in one spot, which can lead to the formation of blood clots. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how effective and safe REGN7508 and REGN9933, individually, … |
REGENERON PHARMACEUTICALS | 2026-02-24 |
| 67 | Efficacy and Safety of 6Degrees MyMove Interactive Virtual Reality Compared to Passive Virtual Reality in Subacute Stroke and Traumatic Brain Injury Rehabilitation: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke and traumatic brain injury frequently result in persistent upper and lower limb motor impairment. While conventional rehabilitation improves outcomes, patient adherence and training intensity remain limiting factors. Immersive virtual reality (VR)-based therapy may enhance neuroplasticity by delivering high-intensity, task-oriented motor practice with enriched sensory feedback. This randomized controlled trial evaluates the efficacy and safety of the 6Degrees MyMove interactive VR system compared to passive VR exposure in individuals undergoing subacute inpatient rehabilitation after stroke or traumatic brain injury. Sixty participants will be randomized 1:1 to receive either interactive VR-based motor training or passive VR viewing, … |
RACHEL DANKNER; | 2026-03-02 |
| 68 | Effect of ZaStaprazan on Platelet Reactivity of Clopidogrel After PercuTaneous CoronAry InteRvention: A Randomized Double-Blind Pilot Study (EZ-STAR) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the clinical utility of zastaprazan compared to proton pump inhibitors (PPIs) in patients receiving dual antiplatelet therapy (DAPT) including clopidogrel after percutaneous coronary intervention (PCI), by comparing their effects on platelet reactivity. |
YONGCHEOL KIM; | 2026-03-13 |
| 69 | Exploratory Comparison of Movement Observation/Imagery-Timed Robot Activation and Repetitive Robot Activation on Training Effects and Neurophysiological Responses in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial compares two types of robotic hand rehabilitation-brain wave (EEG)-timed therapy versus simple repetitive therapy-to see which is more effective for recovering hand function in patients with chronic stroke. Participants will be randomly assigned to either group and will attend sessions using a wearable robotic hand device while wearing an EEG cap. In the EEG-timed group, the robot assists hand movements when participants successfully imagine moving and create specific brain signals, whereas in the repetitive group, … |
NAM-JONG PAIK; | 2026-03-10 |
| 70 | Effects of Thoracic Spinal Manipulation on Balance, Fall Risk, and Thoracic Mobility in Patients With Chronic Stroke: A Randomized Crossover Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the study is to investigate the effects of thoracic spinal manipulation on balance, fall risk, and thoracic mobility of the patients with chronic stroke. |
OMER DURSUN; | 2026-04-02 |
| 71 | The 10-Year Extended Follow-up of The Different Antiplatelet Strategies After Coronary Artery Bypass Grafting Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the very long-term effects of different antiplatelet strategies in patients who underwent coronary artery bypass grafting (CABG) and participated in the original DACAB trial. The main questions it aims to answer are: Does one year of treatment with ticagrelor plus aspirin (dual antiplatelet therapy) after CABG reduce the risk of major adverse cardiovascular events (MACE) over 10 years compared with aspirin alone or ticagrelor alone? What are the long-term safety outcomes, including major bleeding events, … |
ZHU YUNPENG; | 2026-03-18 |
| 72 | Echocardiographic Assessment The Different of Septic Shock Resuscitation: Comparison of Volume Expansion Versus Vasopressor Administration PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the change of hemodynamic response from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient. The main question it aims to answer is: How hemodynamic response change from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient? Participants already receiving the appropriate resuscitation at that time by their medical staff as part of their regular medical care for septic shock. The echocardiogram will assess before and after resuscitation. |
SURAT TONGYOO; | 2026-02-27 |
| 73 | Effect of Neuromuscular Stimulation and Mindfulness Exercise on Pulmonary, Physical Functions and Stress in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: It is an interventional study in which 60 stroke patients were estimated to enroll according to random allocation and divided into two groups. The experimental group will receive neuromuscular stimulation and mindfulness , while the control group will receive neuromuscular stimulation only. |
MARWA MAHMOUD ELSAYED MAHMOUD; | 2026-03-13 |
| 74 | Investigation of The Acute Effects of Wearable Electrical Stimulation on Spasticity, Upper and Lower Extremity Functions, and Gait in Individuals With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if the EXOPULSE Mollii Suit Wearable Electrical Stimulation works to reduce spasticity and improve functional capacity in individuals with stroke. It will also evaluate the acute (immediate) effects of the intervention. The main questions it aims to answer are: 1. Does wearable electrical stimulation reduce the severity of spasticity in participants? 2. Does wearable electrical stimulation improve upper extremity performance, balance, and gait in participants? 3. What impact does the intervention have on pain, fatigue, … |
MUHAMMED KILINÇ; | 2026-03-12 |
| 75 | Effect of Non-Invasive Auricular Vagus Nerve Stimulation on The Rehabilitation of Pharyngo-Laryngeal Dysphagia in Patients Over 70 Years Old After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates the effect of non-invasive transcutaneous auricular vagus nerve stimulation (tVNS-E) on swallowing rehabilitation in patients over 70 years old after stroke. Participants will be randomly assigned to standard speech therapy with either active tVNS-E or a sham device, over four sessions per week for three weeks. Swallowing function and quality of life will be assessed before and after the intervention to evaluate the potential benefit of tVNS-E. |
JULIEN POIRIER; | 2026-02-24 |
| 76 | Comparison of Robot-Assisted Gait Training and Visual Feedback Balance Training on Balance and Gait Outcomes in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke frequently leads to balance impairment and gait dysfunction, increasing fall risk and limiting functional independence. Technology-assisted rehabilitation approaches such as robot-assisted gait training and visual feedback balance training have been shown to improve balance and mobility in stroke patients. This randomized, assessor-blinded clinical trial aims to compare the effects of robot-assisted gait training and visual feedback balance training on balance and gait outcomes in patients with subacute and chronic stroke. Both interventions are part of routine clinical rehabilitation practice. Participants will be evaluated at baseline and after 4 weeks of intervention using clinical balance, gait, and functional assessments. |
ABANT IZZET BAYSAL UNIVERSITY | 2026-03-18 |
| 77 | The Savvy for Stroke Survivors Study: Testing A Novel Tool to Help Stroke Survivors Take Their Medication PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to test if Savvy, a multimodal intervention (consisting of psychological exercises, a weekly pill organizer, and a text message reminder system) can improve medication adherence in stroke survivors. The main questions it aims to answer are: * Can the Savvy tool improve medication adherence in stroke survivors compared to usual care? * Does the use of the Savvy tool lead to better blood pressure control after a stroke? The investigators will compare the use of the Savvy intervention to a control group that receives usual care, … |
SANJULA DHILLON SINGH; | 2026-03-06 |
| 78 | Radiation- and Contrast-Free Transcatheter Aortic Valve Replacement for Aortic Regurgitation Under Transthoracic Echocardiography Guidance PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Transcatheter aortic valve replacement (TAVR) is an established therapy for severe aortic valve disease, yet conventional workflows rely on fluoroscopy and iodinated contrast, exposing patients and operators to ionizing radiation and posing challenges for individuals with chronic kidney disease, contrast allergy, or other contraindications. In patients with native aortic regurgitation, the absence of annular/leaflet calcification and frequent annular dilation can further complicate device positioning and anchoring, increasing the procedural dependence on precise imaging guidance. Transthoracic echocardiography (TTE) provides real-time assessment of valve anatomy, coaxial alignment, depth control, and immediate hemodynamic results, … |
PAN XIANGBIN; | 2026-03-09 |
| 79 | Evaluation Of The Relationship Between The Conut Score And Balance And Functional Status In Patients With Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim of this study is to evaluate the relationship between the CONUT score, which reflects nutritional status, and balance performance in patients with chronic stroke. The secondary aims are to investigate the association between the CONUT score and functional status and stroke-specific quality of life, as well as to assess the relationships of mid-upper arm circumference, an anthropometric indicator of nutritional status, and ultrasonographic rectus femoris muscle thickness, which reflects muscle mass, with balance performance, functional status, and stroke-specific quality of life. In addition, the study aims to examine the relationships between bone mineral density and balance, … |
MARMARA UNIVERSITY | 2026-03-24 |
| 80 | Fatigue Severity Independently Predicts Health-Related Quality of Life in Stroke Survivors: A Cross-Sectional Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This observational cross-sectional study aims to examine the association between fatigue severity and health-related quality of life in individuals with stroke. Fatigue severity will be assessed using the Fatigue Severity Scale (FSS), and quality of life will be evaluated using the Nottingham Health Profile (NHP). The primary analysis will investigate the relationship between FSS total score and NHP total score and domain scores. |
OSMAN COBAN; | 2026-03-30 |
| 81 | Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis (RICSICAS): A Prospective, Randomized Controlled, Blind Endpoint, Single-Center Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Remote ischemic conditioning (RIC) has emerged as a promising non-invasive strategy to protect the brain, with evidence suggesting its benefit in patients with carotid artery stenting (CAS). However, the long-term benefit and safety of chronic RIC in this population remain unknown. This trial aims to evaluate whether chronic RIC reduces the incidence of major vascular events and improves clinical outcomes in high-risk patients with carotid artery stenosis who received CAS. |
HUI-SHENG CHEN; | 2026-04-03 |
| 82 | Evaluation of An AsPirin-free Strategy With TicAgrelor in PatieNTs WitH A Myocardial Infarction TreatEd Medically AlONe (PANTHEON) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: In patients with a myocardial infarction (MI) treated medically alone, the objective of the PANTHEON trial is to evaluate if ticagrelor monotherapy reduces bleeding events, without an increase in patient-oriented ischemic events, compared with standard dual antiplatelet therapy (DAPT) with aspirin and ticagrelor for 12 months. |
GUILLAUME MARQUIS-GRAVEL; | 2026-03-10 |
| 83 | Digital Mirror Therapy in Poststroke Rehabilitation: Efficacy and Patient-reported Facilitators and Barriers to Adherence PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: While conventional mirror therapy is a Level A recommended rehabilitation for poststroke upper extremity recovery, digital mirror therapy-enabled by augmented reality and computer vision-offers a promising alternative with potential for greater engagement and enriched sensory feedback. However, systematic comparisons of their clinical and physiological benefits, alongside an understanding of patient experiences with digital therapy, are lacking. Objectives: This randomized controlled trial will compare the efficacy of digital versus conventional mirror therapy for upper extremity rehabilitation in people after chronic stroke. The evaluation will focus on three areas: 1) clinical outcomes in motor function and community integration; … |
JACK JIAQI ZHANG; | 2026-03-10 |
| 84 | The Effect of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Sarcopenia and Clinical Outcomes in Patients With Ischemic Stroke: A Single-Blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the effect of post-stroke sarcopenia on prognosis and clinical outcomes in patients with ischemic stroke and to compare the effects of High Intensity Interval Training (HIIT) and Moderate Intensity Continuous Training (MCIT) exercise programs on muscle mass, as well as on functional capacity, quality of life, and clinical outcomes. |
SÜMEYYE AKÇAY; | 2026-03-25 |
| 85 | A Pragmatic Randomized Trial to Evaluate The Effect of Recombinant Herpes Zoster Vaccine on Major Adverse Cardiovascular Events and Dementia in Adults Aged 65 Years or Above PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: DAN-ZOSTER is a nationwide randomized study investigating whether vaccination against herpes zoster (shingles) can reduce the risk of cardiovascular disease and dementia in older adults. Herpes zoster is caused by reactivation of the varicella-zoster virus and becomes more common with increasing age. Some observational studies have suggested that vaccination against herpes zoster may also lower the risk of heart attacks, strokes, and dementia, but this has not been confirmed in randomized clinical trials. In this study, … |
TOR BIERING-SØRENSEN; | 2026-03-20 |
| 86 | Long-Term Cardiovascular and Cerebrovascular Outcomes After Retinal Artery Occlusion: A Nationwide Study PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: Retinal artery occlusion (RAO) is a rare but vision-threatening vascular disorder that is commonly caused by embolic events originating from the heart or carotid arteries. Patients with RAO are known to have an increased risk of subsequent cardiovascular and cerebrovascular events, including ischemic stroke and myocardial infarction. However, long-term outcomes and optimal medical treatment strategies for these patients remain insufficiently characterized. The purpose of this nationwide population-based study is to investigate the incidence of long-term cardiovascular and cerebrovascular outcomes in patients diagnosed with retinal artery occlusion using the Korean National Health Insurance Service (NHIS) database. In addition, … |
SEUNG HUN LEE; | 2026-03-19 |
| 87 | A Coronary Computed Tomography Angiography-guided Intensive Intervention for Population at High Risk for Cardiovascular Disease in Rural China: A Cluster Randomized Controlled Trial PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The CARDIAC trial is a prospective, parallel, open-label cluster randomized trial that aims to determine the effectiveness of a coronary computed tomography angiography (CTA)-guided intensive intervention strategy, as compared with standard care, on reducing the incidence of major adverse events (MACE) at 18 months among high-risk cardiovascular populations in rural China. An extended observational follow-up at 36 months will be conducted to further evaluate the effect on long-term clinical outcomes. |
YU BO; | 2026-02-18 |
| 88 | A Pragmatic, Multicentre, Adaptive, Prospective, Open-label, Blinded Endpoint Randomized Clinical Trial Assessing The Impact of Head-of-bed Positioning at 0-degrees Versus 30-degrees or More on Functional Recovery Following Endovascular Thrombectomy for Anterior Circulation Large Vessel Occlusion Stroke PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Endovascular thrombectomy (EVT), also known as clot retrieval, is a procedure that improves recovery for people who suffer a stroke by removing blood clots from large blood vessels in the brain. However, … |
ARISTEIDIS KATSANOS; | 2026-02-05 |
| 89 | BASel Kosten-Effektivitäts-Trial: Drug-coated BALLoon Vs. Drug-eluting Stent Strategy in High-risk Patients With Coronary Artery Disease PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of this randomized, multicenter, international, open-label clinical trial is to demonstrate that, in the context of percutaneous coronary intervention for complex coronary artery disease, a SeQuent® SCB interventional strategy is non-inferior to a new-generation DES strategy in terms of a 12- and 36-month composite of Target Vessel Failure (TVF), that includes: * cardiovascular death (CV death), * target vessel related MI (TV-MI), * clinically indicated target vessel revascularization (ci-TVR), … |
B BRAUN MELSUNGEN AG | 2026-01-23 |
| 90 | A Multicenter, Randomized, Open-Label, Blinded-Endpoint Trial of Tenecteplase Versus Dual Antiplatelet Therapy in Mild Disabling Ischemic Stroke With Large Vessel Occlusion Beyond 4.5 Hours (TIME-MINOR Trial) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: To verify the efficacy and safety of intravenous tenecteplase (TNK) in patients with disabling minor stroke and large vessel occlusion (LVO) within a 4.5-24 hour time window. |
CHUANSHENG ZHAO; | 2026-03-17 |
| 91 | An Individualized Video-based Stroke Education Platform for Stroke Survivors and Caregivers PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this multicenter randomized trial is to evaluate the impact of a personalized video-based stroke education platform on patient-centered and health system-centered outcomes. The main questions this study aims to address are: 1. Does a personalized, video-based educational platform improve stroke knowledge? 2. Does a personalized, video-based educational platform reduce post-discharge health system utilization? 3. Do different strategies of nudging improve engagement with educational material after hospital discharge? In order to determine the effect of this personalized stroke education strategy, … |
CHRISTOPHER FAVILLA; | 2026-01-08 |
| 92 | Post-Stroke Enhancement of Delirium Outcomes With Reduction in Neuro-checks PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: There have been limited studies on delirium in patients hospitalized with acute stroke. There have been no studies on the potential impact of overnight neuro-checks and resulting sleep disruption on delirium or other outcomes. Additional research is needed to determine if overnight checks are necessary or even harmful. We aim to find out if stopping overnight neuro checks may prevent delirium and benefit the patient. |
MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2026-02-17 |
| 93 | Efficacy and Safety of Eptifibatide Therapy Following Intravenous Thrombolysis in Acute Ischemic Stroke Patients Within 4.5 to 24 Hours After Onset: A Multicenter, Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, open-label, blinded-endpoint clinical trial designed to evaluate the efficacy and safety of early administration of eptifibatide following intravenous thrombolysis in patients with acute ischemic stroke who present 4.5 to 24 hours after symptom onset. |
ZHONGMING QIU; | 2026-01-16 |
| 94 | Impact of Manual Preference on Motor Deficits After Stroke PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective, single-center observational study evaluates whether handedness is associated with upper-limb motor recovery after a recent unilateral stroke. Adults admitted to the stroke unit with a confirmed unilateral stroke within 5 days are included if they do not object to participation. Upper-limb impairment is assessed early after stroke and at 6 months using standardized clinical scales. Handedness is determined by self-report, and the Edinburgh Handedness Inventory is administered when feasible. The main hypothesis is that left-handed participants may show better upper-limb motor recovery at 6 months than right-handed participants, potentially due to differences in brain motor network lateralization. |
JULIEN BONNAL; | 2026-01-29 |
| 95 | Plunger Stroke Trial: A Comparison of Cyclic Manual Direct Aspiration Thrombectomy (Plunger Technique) Vs. Static Manual Direct Aspiration Thrombectomy for Treatment of Acute Large Vessel Occlusion Stroke With The Raptor Aspiration Catheter PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective, randomized controlled trial will compare two manual aspiration techniques for treating acute ischemic stroke due to large vessel occlusion: cyclic aspiration (Plunger technique) and static aspiration. Both techniques use FDA-approved devices (Raptor Aspiration Catheters and VacLok syringes) and are standard of care. Approximately 500 participants across 20 sites will be randomized to one of the two techniques. The primary endpoint is First Pass Effect (TICI 2c/3 after first attempt), with secondary endpoints including overall recanalization and 90-day functional outcomes. Results will address a critical gap in optimizing aspiration thrombectomy techniques. |
MICHAEL FROEHLER; | 2026-01-08 |
| 96 | High Coverage CARotid Stenting Vs. Medical Management Alone to Prevent EmboliSm From SymptomaTic Non-stenotic CARotid Disease (SyNC) – CARESTAR PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Goal is to analyse the clinical safety and efficacy of the CARESTO® heal Stent within standard clinical routine for the treatment of patients with symptomatic non-stenotic carotid disease (SyNC) and with high-risk plaque features for stroke recurrence compared to medical treatment alone with respect to the mid- and long-term clinical outcomes. |
ACANDIS | 2026-03-04 |
| 97 | Effect of Emergency Stroke Unit With NeuAngio-CT Direct for Acute Ischemic Stroke and Suspected Intracranial Large Vessel Occlusion (ESU-ACT) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Rationale: Acute ischemic stroke caused by large-vessel occlusion (LVO) requires rapid recanalization to minimize neurological damage, as shorter onset-to-reperfusion times are strongly associated with better clinical outcomes. Conventional management workflows, which involve separate non-contrast CT or multimodal imaging assessments prior to transfer to the angiography suite, often introduce significant delays. The implementation of a one-stop management model using a hybrid sliding-gantry CT/DSA suite allows for immediate diagnosis and subsequent intervention in a single clinical environment, potentially streamlining the transition to treatment. Therefore, … |
YONGJUN WANG; | 2026-03-06 |
| 98 | Evaluation of A Point-of-care Lateral Flow Assay in GFAP and D-dimer in Diagnosis of Large Vessel Occlusion Acute Ischemic Stroke in A Pediatric Hospital PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to test the efficacy of a rapid bedside blood test in determining if a stroke is happening in children who present to the emergency department with stroke symptoms. The main questions it aims to answer are: * To determine the sensitivity of detecting a large vessel occlusion (LVO) as the etiology of acute ischemic stroke (AIS) in a pediatric population using a point-of-care blood-based assay (LVOne). * To determine the positive predictive value (PPV) of LVOne in a pediatric population Participants will: * Provide a small sample of blood to be used to test the accuracy of the device. * Participants will still receive all standard of care work-up for stroke, which could include computed tomography/magnetic resonance imaging (CT/MRI). |
POK-MENG SEE; | 2026-03-16 |
| 99 | Randomized Controlled Trial – Catheter Ablation Combined With Left Atrial Appendage Occlusion Versus Catheter Ablation Combined With Oral Anticoagulation for Elderly Frailty Patients With Atrial Fibrillation: Comparison of Efficacy and Safety PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Atrial fibrillation (AF) is the most common arrhythmia, significantly increasing the risk of stroke, heart failure, hospitalization and death in patients. Studies have shown that standardized anticoagulation can effectively reduce the risk of stroke by 64% and the risk of death by 26% in AF patients. Therefore, both European and American guidelines recommend standardized oral anticoagulation (OAC) as an important treatment strategy for stroke prevention in AF patients. However, … |
YUMEI XUE; | 2026-03-02 |
| 100 | The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion: A Multicenter, Prospective, Open-Label, Endpoint-Blinded, Randomized Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study assesses the efficacy and safety of endovascular treatment for acute mild basilar artery occlusion within a multicenter, prospective, open-label, endpoint-blinded, randomized controlled clinical trial. |
FENG GAO; | 2026-02-05 |
| 101 | Mechanism Study of G Protein-coupled Receptor 81 in Multiple Organ Dysfunction of Heat Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Heat stroke is one of the common acute and critical conditions in the ICU, characterized by a high incidence and mortality rate, and there is still a lack of effective and precise treatment methods. The latest research indicates that G protein-coupled receptor 81 (GPR81), as an endogenous receptor of lactic acid, can regulate immune responses by up-regulating the expression of inflammatory factors and the chemotaxis of neutrophils, … |
SECOND AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY | 2026-01-16 |
| 102 | Reducing Risk of Stroke and DementIa In PatientS With COVert CERebrovascular Disease: A Pilot and Development Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the DISCOVER study is to pilot acceptable approaches to people with covert cerebrovascular disease (CCD) and their follow-up. This is the first step in designing efficient randomised trials of treatments to reduce the risk of stroke or dementia in people with CCD. |
UNIVERSITY OF EDINBURGH | 2026-02-18 |
| 103 | The Combination Model of 30 Degree Head Up and Murottal Therapy on Blood Pressure, Pulse Rate, Respiratory Rate, Pain Degree, and Projectile Vomiting in Stroke Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effects of a combination of a 30-degree head-up position and murottal therapy on physiological and symptom outcomes in stroke patients. The intervention is expected to influence blood pressure, pulse rate, respiratory rate, pain level, and the incidence of projectile vomiting. Stroke patients will receive standard care with the addition of the combined intervention. The results of this study may support non-pharmacological nursing interventions to improve patient comfort and clinical stability. |
FILA DIANA NURHAYATI; | 2026-02-12 |
| 104 | Effectiveness and Safety of Intra-arterial Tenecteplase Bridging Therapy Following Incomplete Recanalization After Mechanical Thrombectomy for Acute Anterior Circulation Large Vessel Occlusion: A Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy and safety of intra-arterial TNK bridging therapy following incomplete recanalization (2b ≤ eTICI \< 3) after mechanical thrombectomy for acute anterior circulation large vessel occlusion. |
CHUANSHENG ZHAO; | 2026-03-13 |
| 105 | Pulse Field Ablation Based Pulmonary Vein Isolation Concomitant With Left Atrial Appendage Closure – The COCONUT II Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A multicenter, prospective registry of concomitant Farapulse (Boston scientific) based PVI and Watchman Flx device (Boston scientific) based LAAC procedures was planned in order to assess the acute and mid-time safety, efficacy and efficiency of this approach (COCONUT II study). If available the transseptal puncture will be performed by the VersaCross System (Boston scientific). If already available LAAC procedure will be performed utilizing the Watchman Flx pro device (Boston scientific) or the Watchman Flx device (Boston scientific). For procedure planning, … |
CHRISTIAN-HENDRIK HEEGER; | 2026-03-12 |
| 106 | Effect of Combining Mirror Therapy With Soft Robotic Glove on Hand Function Recovery in Post-Stroke Hemiplegic Patients: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Post-stroke hemiplegia frequently results in impaired upper limb function, which significantly affects independence and quality of life. Various rehabilitation approaches have been developed to improve motor recovery, including mirror therapy and robotic-assisted training. Mirror therapy uses visual feedback to stimulate neural plasticity and enhance motor recovery, while soft robotic gloves assist repetitive hand movements and facilitate functional training. This randomized controlled trial aims to investigate the effect of combining mirror therapy with a soft robotic glove on hand function recovery in patients with post-stroke hemiplegia. Participants will be randomly assigned to different intervention groups receiving mirror therapy, … |
MOHAMMED HINDI JARYAN; | 2026-03-12 |
| 107 | Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Safety and Efficacy of Anakinra for Futile Reperfusion Following Endovascular Treatment in Patients With Acute Ischemic Stroke (SAFE) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to explore the safety and efficacy of different dose of Anakinra compared to standard medical care for patients with acute ischemic stroke who have achieved successful recanalization after endovascular thrombectomy. |
YUNYUN XIONG; | 2026-02-20 |
| 108 | Role of Vessel Wall MRI in Differentiaition Between Intrcranial Atherosclerotic Disease and Vasculitis As Causes of Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This work aims to clarify the diagnostic ability of vessel wall MRI to differentiate between intracranial atherosclerotic disease and vasculitis as causes of ischemic stroke, thereby guiding appropriate treatment and improving patient outcomes. |
MAHMOUD ABDELBASET MAHMOUD MOHAMED; | 2026-03-04 |
| 109 | Comparative Effects of Pelvic Proprioceptive Neuromuscular Facilitation and Multiplanar Trunk Training on Balance and Functional Mobility in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To compare the effects of Pelvic Proprioceptive Neuromuscular Facilitation and multiplanar trunk exercises on balance and functional mobility in stroke patients |
SANA RIAZ; | 2026-04-01 |
| 110 | Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research will explore if brain stimulation combined with virtual reality therapy improves visual impairment. The stimulation technique is called low-intensity focused ultrasound stimulation (LIFUS). The treatment uses ultrasound to stimulate vision specific parts of the brain. Before this therapy, … |
DUKE UNIVERSITY | 2026-02-20 |
| 111 | Voice-Induced Motor Intention to Enhance Upper Limb Rehabilitation Efficacy of Exoskeleton Robots for Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate whether combining motor imagery (the mental visualization of movement) with robotic exoskeleton therapy can improve upper limb recovery in stroke patients. Conventional robotic therapy often involves passive movement driven by the machine. In this study, patients in the experimental group will use their own voice to trigger the robot (e.g., saying bend arm) while simultaneously imagining the movement. The research will compare this voice-enhanced active approach with traditional passive robotic training to see if it better promotes brain-to-muscle signal recovery and improves overall arm function . |
TAIPEI HOSPITAL MINISTRY OF HEALTH AND WELFARE | 2026-02-12 |
| 112 | Effect of Interactive Games Based Hand Training on Hand Dexterity and Functional Outcome in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This current study will be designed to determine the effect of smart tablets hand training applications on hand functions and functional outcome in patients with stroke. Tablet-based hand function training app with smart tablet exercises: Patients in the study group will receive 20 min of smart tablet active hand therapy. Patients in the study and control group will receive 30 min of conventional physical therapy program. This program consists of neurodevelopmental facilitation techniques organized specifically for each patient, range of motion exercises, strengthening exercises . It includes the following functional tasks (reaching, grasping, lifting and placing objects). |
MARWA MOSTAFA ABDEL MONEIM AFIFI; | 2026-03-09 |
| 113 | The Effect of Blood Flow Restriction Training Combined With Transcranial Magnetic Stimulation on Limb Function in Hemiplegic Patients After Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial aims to evaluate whether combining blood flow restriction training (BFRT) with repetitive transcranial magnetic stimulation (rTMS) improves limb function in stroke patients with hemiplegia. A total of 69 participants will be randomly assigned to three groups: conventional rehabilitation alone (control group), conventional rehabilitation plus rTMS, or conventional rehabilitation plus BFRT combined with rTMS. The intervention period is 4 weeks, with assessments conducted at baseline and at the end of treatment. The primary outcome is the change in upper extremity Fugl-Meyer Assessment (FMA-UE) score, which measures motor function recovery. Secondary outcomes include Wolf Motor Function Test, … |
SHENAO DU; | 2026-03-06 |
| 114 | Effects of Inspiratory Muscle Training on Performance in Young Swimmers: A Comparison of Land- and Water-based Applications PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate the effects of four weeks of land- and water-based inspiratory muscle training (IMT) on performance and selected physiological variables in young swimmers. A total of 30 competitive swimmers (22 males and 8 females), who have been training regularly for at least two years, will be voluntarily recruited and assigned to three groups: Land + IMT, Swimming + IMT, and Water + IMT. To compare the effects of different training protocols and evaluate their specific contributions to performance, … |
BILGEHAN MELIKŞAH ÇALOĞLU; | 2026-03-25 |
| 115 | The Role of Blood-Based Molecular Clock Biomarkers in Predicting The Onset Time of Acute Ischemic Stroke: A Prospective Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Acute ischemic stroke (AIS) is a major cause of mortality and long-term neurological disability worldwide. The effectiveness of reperfusion therapies such as intravenous thrombolysis and mechanical thrombectomy is highly dependent on the time elapsed since symptom onset. However, in approximately 15-25% of patients, the exact onset time cannot be determined because symptoms begin during sleep (wake-up stroke) or the onset is otherwise unclear. This uncertainty often prevents patients from receiving time-dependent reperfusion treatments. Currently, … |
EJDER SAYLAV BORA; | 2026-03-06 |
| 116 | Radiation- and Contrast-Free TAVR for Aortic Regurgitation Under Transesophageal Echocardiography Guidance PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Under contemporary practice, transcatheter aortic valve replacement (TAVR) is typically performed with fluoroscopic visualization and repeated injections of iodinated contrast. While effective, this paradigm introduces cumulative radiation exposure to both patients and staff and can be problematic in individuals with renal dysfunction, prior contrast reactions, or other situations where contrast use is undesirable. Treating native aortic regurgitation (AR) adds another layer of complexity: limited valvular/annular calcification, enlarged annular dimensions, and dynamic root motion may reduce frictional purchase and make prosthesis stabilization more demanding, thereby heightening the need for continuous, high-fidelity intraprocedural imaging. Transesophageal echocardiography (TEE), … |
PAN XIANGBIN; | 2026-03-06 |
| 117 | Randomized Controlled Trial of Artificial Intelligence-Driven Virtual Reality Rehabilitation for Upper Limb Recovery in Acute and Subacute Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Upper limb motor deficits are common after stroke, and early rehabilitation is crucial for functional recovery. Virtual reality (VR) combined with artificial intelligence (AI) has shown potential to enhance motor learning, but evidence from randomized controlled trials in acute and subacute hospitalized patients is limited. Objective: To evaluate whether AI-driven VR rehabilitation in addition to standard care improves upper limb motor recovery compared with standard rehabilitation alone in acute and subacute stroke patients. Design: Prospective, assessor-blinded, randomized controlled trial with stratified 1:1 allocation by baseline Fulg Meyer Assessment Score.S Participants: Adults (≥18 years) with confirmed acute or subacute stroke, … |
BEATRIZ VILLARRUBIA; | 2026-03-06 |
| 118 | NeuroRecoVR: Phase I Split-Belt Treadmill Dosing for Subacute Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: After experiencing a stroke, many individuals encounter difficulties with walking and balance, which can significantly impact their independence. Recent studies have indicated that split-belt treadmill (SBT) training is effective for improving gait metrics, including walking speed and step length asymmetry. The SBT allows each leg to move at different speeds, which has been shown to help chronic stroke survivors learn to walk more symmetrically. However, there is limited knowledge about the dose participants should receive and the safety of SBT training in the early stages of recovery, which is a crucial period for rehabilitation. To address this gap, … |
SEAN DUKELOW; | 2026-03-13 |
| 119 | Effects of Augmented Reality Functional Integrated Training (AR-FIT) on Balance and Mobility in Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The present study aims to develop and validate an evidence-based functional balance task library for Augmented Reality-Functional Integrated Training (AR-FIT), incorporating standardized real-object integration through expert consensus and pilot usability testing. Furthermore, the study seeks to determine the effects of AR-FIT on balance and functional mobility in stroke survivors in comparison to conventional Augmented Reality \& task oriented training over an eight-week intervention period. In addition, it intends to evaluate participant motivation, engagement, and perceived task realism during AR-FIT using structured questionnaires and post-intervention interviews, thereby examining both clinical effectiveness and user-centered experience outcomes. |
ABRISH HABIB ABBASI; | 2026-03-23 |
| 120 | Sensory Mechanisms of Manual Dexterity Recovery After Stroke: A Prospective Cohort Study of Prediction and Cerebral Correlates PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In the proposed research, we will assess motor and sensory functions of the hand using clinical tests and a tool designed to measure manual dexterity combined with vibrotactile stimulation. We will also evaluate the integrity of brain structure and function using MRI. |
CENTRE HOSPITALIER ST ANNE | 2026-01-14 |
| 121 | Validity and Reliability of The Hypertonia Assessment Tool (HAT) in Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, the validity and reliability of the Hypertonia Assessment Tool (HAT), which has previously been validated in the pediatric cerebral palsy (CP) population, will be evaluated in adult individuals who have experienced a stroke. The HAT is a specific clinical instrument designed to differentiate subtypes of hypertonia, including spasticity, dystonia, and rigidity. Accurate classification of hypertonia subtypes following stroke is crucial for guiding rehabilitation strategies. However, … |
ZEYNEP DEMIR; | 2026-02-24 |
| 122 | Evaluating The Improvement of Stepping Quality By Using Adapted Shoes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is the leading cause of acquired disability in adults. Stroke causes death in 10% of patients, disability and functional handicap in 60% of cases. Sequelea of hemiplegia include spasticity resulting in great difficulty and slowness in walking, gait instability, increasing the risk of falls. Deambulation may need help (cane, crutch, tripod cane, walker). Lower limb spasticity includes hypertonia of extensors (gluteus maximus, quadriceps, posterior gastrocnemius) resulting in equinovarus. A neurology deficit may be present on ipsilateral lower limb flexors. Hence the patient walks with rubbing of the tip of the foot (tip-toeing gait), … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2026-02-11 |
| 123 | Drug Coated Balloon Vs. Drug-eluting Stent in Patients With Coronary Artery Disease PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: Studies exploring the feasibility of drug-eluting balloon (DCB) in de-novo coronary lesions are limited. There are scarce data comparing DCB with drug-eluting stent (DES) in patients with high bleeding risk (HBR), a situation in which long-term maintenance of dual antiplatelet therapy (DAPT) is a clinical dilemma. This target trial emulation aims to compare clinical outcomes between DCB angioplasty and conventional DES implantation in de-novo coronary lesions in patients with coronary artery disease. |
KI HONG CHOI; | 2026-03-02 |
| 124 | Efficacy of Immediate Versus Staged Complete Revascularization in Patients With NSTE-ACS and Multivessel Disease (FUTURE II) PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, multi-center, randomized controlled, open-label, blinded endpoint assessment study. The objective is to compare the 1-year incidence of major adverse cardiovascular and cerebrovascular events (MACCE) between two treatment strategies-immediate complete revascularization and staged complete revascularization-in NSTE-ACS patients with multivessel disease (MVD). NSTE-ACS patients who meet other the inclusion and exclusion criteria will be randomized into the following two groups after signing an informed consent form: Intervention group Immediate Complete Revascularization: Emergency PCI for the culprit vessel is performed successfully, and simultaneous PCI is conducted for non-culprit vessels that meet the defined criteria (visually estimated diameter ≥2.5 mm, … |
JUN PU; | 2026-01-30 |
| 125 | A Prospective, Multicenter, Observational Study Evaluating Safety and Effectiveness of SAPIEN 3 Transcatheter Aortic Valve Replacement for Type-0 Bicuspid Aortic Valve Stenosis Patients in China PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In China, bicuspid aortic valve (BAV) represents a significantly high proportion of the transcatheter aortic valve replacement (TAVR) population. The application of TAVR in patients with BAV is challenging due to complex anatomy. To date, no prospective study has evaluated the Sapien 3 TAVR in patients with Type-0 BAV. |
PAN XIANGBIN; | 2026-03-27 |
| 126 | Effect of Wobble Board Exercises Versus Swiss Ball Exercises on Balance and Functional Stability of Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A stroke is characterized as a condition in which the brain’s main arteries get clogged, reducing oxygen flow and potentially leading to death or severe disability. There are various types of strokes, such as transient ischemic attack (TIA), hemorrhagic stroke, … |
SOBIA KANWAL; | 2026-03-20 |
| 127 | Comparison of The Clinical and Sonographic Outcomes of NMES and EMG Biofeedback Therapies in Stroke Patients With Glenohumeral Subluxation: Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this single-blind randomized controlled trial is to compare the effects of two therapies-neuromuscular electrical stimulation (NMES) and electromyographic (EMG) biofeedback-in stroke patients with shoulder (glenohumeral) subluxation. The study will evaluate changes in shoulder structure and function by measuring the acromion-greater tuberosity distance, supraspinatus and posterior deltoid muscle thickness, shoulder range of motion, and Brunnstrom stage of the upper extremity and hand. Clinical outcomes such as shoulder pain, stroke-specific quality of life, … |
ŞAHIDE EDA ARTUÇ; | 2026-02-20 |
| 128 | The Relationship Between Diaphragm Morphology and Respiratory Muscle Strength in Subacute Hemiplegic Patients: A Cross-Sectional Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to determine the relationship between diaphragm morphology (diaphragm excursion, end-inspiratory and end-expiratory diaphragm thickness, and thickening fraction) and respiratory muscle strength (maximum inspiratory pressure – MIP and maximum expiratory pressure – MEP) in patients with subacute hemiplegia. |
SÜMEYYE AKÇAY; | 2026-03-05 |
| 129 | Co-designing A Toolkit to Optimise Adherence to Inpatient Stroke Rehabilitation Trial Protocols PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Clinical trials are a type of research that tests if a treatment works well and is safe, so future care can be improved. In stroke rehabilitation, clinical trials are essential for improving the lives of stroke survivors. Clinical trials follow detailed plans called protocols, that explain what activities should be done, by whom and when. This makes sure everyone in the trial does things the same way, so results are fair and consistent. Sometimes, stroke survivors or staff may not follow the trial protocol exactly. For example, … |
JON MARSDEN; | 2026-03-20 |
| 130 | An Artificial Intelligence-Enhanced Longitudinal Cohort Study to Optimize Revascularization Decisions in Patients With Coronary Artery Disease and Immune Thrombocytopenia (The ITP-CAD AI-REVASC Study) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study employs a dual-cohort design to develop and validate a prognostic model for Major Adverse Cardiovascular Events (MACE) following revascularization in immune thrombocytopenia (ITP) patients with Coronary Artery Disease (CAD). The model will be developed and trained using a retrospective multi-center cohort (development/training cohort). Its performance will then be prospectively validated in a separate, consecutively enrolled prospective cohort (validation cohort). The goal is to create an AI-based tool to assist in personalized risk assessment and decision-making for this high-risk population. |
XIAO HUI ZHANG; | 2026-02-23 |
| 131 | Intensive Motor Rehabilitation of Stroke Patients: Evaluation of A Telerehabilitation Program PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is a major cause of motor disability, particularly hemiplegia, and its incidence is increasing as the population ages. Despite partial spontaneous recovery in the first three months, 80% of patients retain a motor deficit after six months, requiring intensive rehabilitation to maximize recovery. However, after hospitalization, access to intensive rehabilitation is limited, due to geographical and mobility constraints, and the lack of reimbursement for private occupational therapy. Telerehabilitation, using digital technologies, can overcome these difficulties by offering interactive, … |
HOSPICES CIVILS DE LYON | 2026-03-05 |
| 132 | Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke As Therapeutic Adjunct 2 PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation. |
OSVALDO J. LAURIDO-SOTO; | 2026-03-02 |
| 133 | A Questionnaire-Based Evaluation of Knowledge Recall, Application, and Action Awareness After Viewing The FAST BEE Stroke Education Video PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This online study evaluates immediate learning outcomes after viewing a short animated FAST BEE stroke-education video (1 minute 51 seconds). After providing electronic consent (and for adolescents aged 13-17 years, parental/guardian consent plus participant assent), participants will watch the video and complete a brief online questionnaire. The questionnaire assesses (1) recall of FAST BEE elements, (2) ability to apply FAST BEE to a stroke scenario involving balance and double vision, and (3) intention to take emergency action (calling emergency services). |
SIJU V ABRAHAM; | 2026-03-02 |
| 134 | Effect of Optokinetic Stimulation on Spatial Neglect and Postural Stability in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to investigate the efficacy of optokinetic stimulation in stroke patients by examining its effects on spatial neglect, static balance, dynamic balance, and weight-bearing symmetry. |
ABEER ABDELMOGHNEY MOHAMED; | 2026-02-20 |
| 135 | TENACITY – A Phase III, Prospective, Randomized, Open-label, Blinded Endpoint Assessment (PROBE) to Assess Efficacy and Safety of I.v. Tenecteplase Vs Standard of Care in Patients With Acute Ischemic Stroke (Including Wake-up Stroke), Last Known Well >4.5 H With Imaging Evidence of Salvageable Ischemic Tissue PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke). This study is for people who had an acute stroke or woke up with a stroke and were last seen well more than 4.5 hours before joining the study. Participants need to have imaging that shows there is brain tissue that can still be saved. They also should not be planned to receive a procedure to remove the blood clot. The purpose of this study is to find out whether a medicine called tenecteplase helps people recover from an acute stroke. Tenecteplase is already used to treat people within 4.5 hours after they had a stroke. This study tests if tenecteplase also helps if it is given more than 4.5 hours after the stroke. Participants are put into 2 groups randomly, which means by chance. One group gets tenecteplase as a single injection into a vein. The other group receives standard medical practice. Participants have an equal chance of receiving tenecteplase or the standard treatment. Participants are in the study for about 3 months. In the beginning, participants stay in the hospital for about 1 week. During the study, participants have 7 clinical examinations or visits. The last 2 of these visits will likely be done from home, allowing participants to complete certain assessments remotely. Doctors regularly test participants’ recovery using a scale that measures the level of disability or dependence in daily activities. The results are compared between the 2 groups to see whether the treatment works. The doctors also check participants’ health and take note of any unwanted effects. |
BOEHRINGER INGELHEIM | 2026-03-31 |
| 136 | The Relationship Between Shoulder Ultrasound Findings and Pain Levels in Acute/Subacute Stroke Patients: A Cross-Sectional Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Hemiplegic shoulder pain is a frequent complication after stroke and may be associated with structural abnormalities detectable by musculoskeletal ultrasound. This prospective cross-sectional observational study aims to evaluate the relationship between shoulder ultrasound abnormality score and pain severity in patients with post-stroke hemiplegic shoulder pain. Pain severity will be assessed using the Visual Analog Scale (VAS) for rest, movement, and night pain. Shoulder ultrasound will be performed using a standardized scoring system to quantify structural abnormalities. The primary objective is to investigate whether ultrasound abnormality burden is associated with pain severity in different clinical conditions (rest, exercise, and night). |
AYSE NAZ KALEM; | 2026-02-23 |
| 137 | An Artificial Intelligence-Assisted Magnetic Resonance Imaging Diagnostic Strategy in A Tertiary Stroke Center-a Diagnostic Accuracy Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Quality improvement study with prospective observational design. The study monitors the diagnostic accuracy of an AI-assisted resident radiologist-termed the AI-ResRad diagnostic strategy-compared to an on-call specialist neuroradiologist-termed the SpecNeuroRad strategy-in interpreting stroke MRIs in patients with known onset. The study includes a pre-planned sub-study evaluating the diagnostic accuracy of neurologists and AI-assisted neurologists. |
STIG HOLM OVESEN; | 2026-02-09 |
| 138 | Effectiveness of Visual Biofeedback-Assisted Oropharyngeal Exercises Combined With Neuromuscular Electrical Stimulation in Patients With Post-Stroke Dysphagia: A Randomized Controlled Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Post-stroke dysphagia is a common complication that negatively affects nutritional status, quality of life, and morbidity. Conventional swallowing rehabilitation, including oropharyngeal exercises and neuromuscular electrical stimulation (NMES), is widely used to improve swallowing function. This randomized controlled clinical study aims to investigate the effectiveness of visual biofeedback-assisted oropharyngeal exercises combined with NMES in patients with post-stroke dysphagia. Participants will be randomly assigned to either a visual biofeedback-assisted exercise group or a conventional exercise group, with both groups receiving NMES. Treatment will be administered five days per week for four weeks. Changes in swallowing function, … |
İLGIN NILHAN MANZAK; | 2026-03-25 |
| 139 | Reducing The Burden of Cardiovascular Events With Antiplatelet Therapy in Patients With IntraCerebral Haemorrhage PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: BEAT ICH will be a pragmatic, randomised, placebo-controlled, blinded, superiority clinical trial aiming to recruit 5676 patients aged ≥18 years who survive ICH and assign them 1:1 to starting antiplatelet monotherapy (Aspirin 75 mg od) versus placebo for the entire duration of the trial for preventing MACE. Recruitment duration is for 2.5 years. The duration of the medication and follow-up will vary based on recruitment timeline. If recruited during the first year of the trial, the patient will take the medication for three years or until the trial ends or an event occurs, … |
JEYARAJ D PANDIAN; | 2026-02-09 |
| 140 | The Effect of Perceived Social Support Levels on Life Satisfaction and Social Participation in Adult Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Given the limited evidence in the literature regarding the effect of perceived social support on life satisfaction and social participation in adults with stroke, this study aimed to investigate the effect of perceived social support on these outcomes. |
SEDA NUR KEMER; | 2026-02-09 |
| 141 | Surgical Techniques to Prevent Perioperative Neurologic Complications in Patients Undergoing Coronary Artery Bypass Grafting PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically: This multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia. |
CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES | 2026-02-19 |
| 142 | Impact of New-onset Insomnia After Coronary Revascularization for Patients With Acute Myocardial Infarction PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: The present study aimed to evaluate the impact of acute insomnia on long-term clinical outcomes in patients underwent PCI or CABG for AMI using the Korean National Health Insurance Service (NHIS) database, and to identify the factors through which insomnia contributes to prognostic determination in this patient population. |
KI HONG CHOI; | 2026-02-18 |
| 143 | SUMMIT RISE Study of Acute Ischemic Stroke Patients Evaluating The Route 92 Medical Reperfusion Systems PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: SUMMIT RISE Study of Acute Ischemic Stroke Patients |
ROUTE 92 MEDICAL | 2026-02-27 |
| 144 | Composition Du Thrombus Dans Les Infarctus Cérébraux : Étude Du Lien Avec Avec Des Biomarqueurs Plasmatiques, L’efficacité Du Traitement, L’étiologie Et Le Pronostic PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study focuses on thrombi collected during mechanical thrombectomy procedures, as well as on plasma biomarkers analyzed concomitantly. The primary objective of the study is to investigate associations and correlations between, on the one hand, the composition of thrombi retrieved during thrombectomy and, on the other hand, plasma biomarkers, treatment response, etiology, and prognosis of ischemic stroke and cerebral venous thrombosis. The secondary objectives of this study are to precisely characterize the biochemical composition of the thrombi (notably using techniques such as enzyme-linked immunosorbent assay \[ELISA\] following extraction of proteins contained within the thrombus), … |
FRANÇOIS DELVOYE; | 2026-02-05 |
| 145 | Effect of Intermittent Pneumatic Compression on Ankle Joint Proprioception and Balance in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to assess the effect of intermittent pneumatic compression on ankle joint proprioception and balance in patients with stroke. |
CAIRO UNIVERSITY | 2026-02-11 |
| 146 | Evaluation of The Effect of Music During Nursing Care on The Confort of Patient Hospitalized in Intensive Care Unit During The Acute Phase of A Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Nurses in Stroke Units and Neurovascular Intensive Care Units (USINV) provide care for patients who have experienced a stroke, a sudden and often devastating event that can result in motor, sensory, visual, cognitive, language, or swallowing impairments. Despite advances in stroke management, it remains the leading cause of acquired disability and the second leading cause of death in France, with 122,422 hospitalizations in 2022 and 773 at our institution in 2023. Acute stroke care guidelines recommend hospitalization in specialized neurovascular intensive care units (USINV), as this setting improves survival and recovery through specialized nursing care, close monitoring, … |
FONDATION HÔPITAL SAINT JOSEPH | 2026-02-27 |
| 147 | Mental Calculus Can Enhance Gait Performance in Post-Stroke Patients: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates the effect of cognitive priming through mental arithmetic on functional mobility in post-stroke patients. It hypothesizes that performing mental calculations (addition, subtraction, multiplication) prior to movement stimulates frontoparietal networks, thereby improving gait speed and dynamic balance compared to a passive control condition. |
AHMAD RIFAI SARRAJ; | 2026-02-12 |
| 148 | Key Technical Research on The Treatment of Post-stroke Cognitive Impairment With Brain Electric Field Therapy Based on Acupoint Regulation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical study investigates whether electroacupuncture can improve thinking and memory in people with cognitive problems after a stroke (Post-Stroke Cognitive Impairment, or PSCI). Participants will be randomly assigned to one of two groups: one group will receive real electroacupuncture, while the other will receive a sham treatment . Both groups will also receive standard medical care.The main goal is to see if the real electroacupuncture leads to greater improvement in cognitive function tests over 6 months compared to the sham treatment. The study will also use brain scans (MRI) and other assessments to understand how the treatment might work. |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2026-02-20 |
| 149 | Effect Of Task-Specific Training With And Without Biofeedback On Balance And Risk Of Falls In Chronic Ischemic Stroke Patients Of Central Lahore, Pakistan, A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled trial aims to evaluate the effects of task-specific training with and without biofeedback compared to conventional physical therapy on balance and fall risk in chronic ischemic stroke patients in Lahore, Pakistan. Sixty-six participants will be randomly allocated into three groups: Group 1 (task-specific training with biofeedback), Group 2 (task-specific training without biofeedback), and Group 3 (conventional physical therapy). The intervention will span 12 weeks, consisting of 36 sessions. Key outcome measures include the Berg Balance Scale, Timed Up and Go Test, and the Barthel Index. Assessments will be conducted at baseline, post-intervention, … |
SYED ALI BEHRAM SUBAZWARI; | 2026-02-19 |
| 150 | Powered Ankle Exoskeleton for Stroke Survivors With Gait Impairment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This work will focus on new algorithms for robotic ankle exoskeletons and testing these in human subject tests. Individuals who have previously had a stroke will walk while wearing a robotic exoskeleton on a specialized treadmill as well as during other movement tasks (e.g., overground, stairs, ramps). The study will compare the performance of the advanced algorithm with not using the device to determine the clinical benefit. |
AARON YOUNG; | 2026-02-17 |
| 151 | Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke. |
VICTOR URRUTIA; | 2026-02-13 |
| 152 | Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Perfusion-guided Endovascular Intervention for Medium Vessel Occlusion Therapy (PIVOT) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to evaluate the efficacy and safety of perfusion-guided endovascular treatment (EVT) compared to standard medical care for patients with acute ischemic stroke due to medium vessel occlusion (MeVO) within 24 hours from symptom onset. |
YUNYUN XIONG; | 2026-02-10 |
| 153 | A Prospective, Single-arm Study Evaluating The Endothelialization Effect and Timeline of AnchorMan® Left Atrial Appendage Occluder in Non-valvular Atrial Fibrillation Patients at High Risk of Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the endotheliation efficacy of the AnchorMane® Left Atrial Appendage Occluder in non-valvular atrial fibrillation patients at high stroke risk. It investigates the rate of complete endotheliation of the occluder at 6 months post-procedure using routine cardiac CTA, providing additional data for clinical application and further product development. Study Size and Duration: This study plans to enrol1 306 patients. All participants will undergo follow up immediately after occluder implantation, prior to discharge or within 7 days post-procedure, at 1 month post-procedure, … |
SHANGHAI ZHONGSHAN HOSPITAL | 2026-02-09 |
| 154 | Safety and Initial Efficacy Study of A Cardiac Surgical Pulsed Field Ablation System for The Treatment of Atrial Fibrillation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a prospective, single-center, single-arm, non-randomized study focused on safety and preliminary efficacy, aiming to evaluate the safety and preliminary efficacy of a cardiac pulsed field ablation device and a single-use cardiac surgical pulsed field ablation electrode for elective cardiovascular surgery combined with Cox-maze IV surgery as a reference treatment for atrial fibrillation. Adult subjects meeting the clinical indications for concomitant cardiac surgery will undergo the Cox-maze IV procedure as a reference, … |
SUZHOU SINUS MEDICAL TECHNOLOGIES | 2026-02-13 |
| 155 | Constraint-Induced Movement Therapy and Bilateral Training in Chronic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is a leading cause of long-term disability, with upper limb spasticity and impaired hand function being common problems in the chronic phase. These impairments significantly affect independence in activities of daily living and overall quality of life. Constraint-Induced Movement Therapy (CIMT) and Bilateral Training (BT) are two widely used neurorehabilitation approaches aimed at improving upper limb motor recovery after stroke; however, … |
ZIKRA AZHAR; | 2026-01-30 |
| 156 | Mechanisms of Recovery Phenotypes: Early Neurovascular Decoupling Trajectories After Revascularization in Acute Ischemic Stroke Using Multimodal Monitoring PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Recanalization therapy is the standard treatment for acute ischemic stroke (AIS), yet patient outcomes remain highly heterogeneous. The underlying mechanisms of this variability are not fully understood. Neurovascular coupling (NVC), the tight link between neural activity and cerebral blood flow, is fundamental for brain function. Its disruption (neurovascular decoupling) after stroke is hypothesized to be a key determinant of recovery, … |
LANG JIN; | 2026-02-12 |
| 157 | 족저압 요약 피드백 제공 유무에 따른 로봇보조보행훈련의 효과: 편마비 환자의 보행 대칭성과 균형에 미치는 영향; The Effect of Robot-Assisted Gait Training With or Without Plantar Pressure Summary Feedback: Impact on Gait Symmetry and Balance in Hemiplegic Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized, single-blind clinical trial is to learn whether a 4-week Lokomat-based gait training program with plantar pressure feedback can improve gait symmetry and balance in adult patients with chronic hemiplegic stroke. The main questions it aims to answer are: Does Lokomat training with plantar pressure feedback improve spatiotemporal gait symmetry, as measured with the GAITRite system, more than Lokomat training without plantar pressure feedback? Does this intervention lead to greater improvements in balance and walking speed, assessed by the Berg Balance Scale (BBS) and the 10-Meter Walk Test (10MWT), … |
YEONJI CHOI; | 2026-01-13 |
| 158 | Effects of Comprehensive Hand Repetitive Intense Strength Training on Upper Limb Function in Children With Pediatric Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Pediatric stroke poses significant challenges due to its impact on a child’s developing brain. Both ischemic and hemorrhagic strokes in children can result in long-term motor, sensory, and cognitive impairments, particularly affecting upper limb function. Comprehensive Hand Repetitive Intensive Strength Training is a structured intervention model that integrates high-repetition, strength-based, and goal-oriented exercises targeting upper limb coordination and use. This study aims to explore the efficacy of CHRIST in improving upper limb function using the ABILHAND-Kids questionnaire to assess changes in manual ability. The study aims to generate pediatric-specific evidence for intensive hand-focused rehabilitation strategies. |
MASHAR HAYAT; | 2026-02-27 |
| 159 | Emulation of The REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials. The investigators’ goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies. |
SHIRLEY VICHY WANG; | 2026-02-18 |
| 160 | Telemedicine-supported Management of Acute Ischemic Stroke in The Basic-level Hospitals PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Telemedicine-supported stroke care can provide standardized guidance to hospitals and regions with limited medical resources, thereby improving treatment outcomes for stroke patients in these areas. While this approach has been widely adopted in many developed countries, its efficacy in guiding basic-level hospitals to manage acute ischemic stroke requires further investigation through large-scale, high-quality studies. This study focused on patients with acute ischemic stroke who sought treatment at basic-level hospitals, aiming to investigate the efficacy and safety of treating acute ischemic stroke with telemedicine-supported management. Hospitals assigned to the experimental group received remote consultation guidance, … |
JI XUNMING; | 2026-02-03 |
| 161 | Effect of Oral Minocycline in Patients With Acute Stroke – A Randomized, Open Label, Prospective Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older. The main questions it aims to answer are: 1. Does Minocycline improve \*National Institutes of Health Stroke Scale\* (NIHSS) scores at hospital discharge and 90 days post-stroke? 2. Does Minocycline reduce stroke-related disability, … |
JOYCE CHEN; | 2026-03-19 |
| 162 | Vojta Therapy Versus Conservative Therapy for Patients With Ischemic Stroke in Regaining Functional Independence PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Main hypothesis: Vojta Therapy shows significantly better results in regaining functional independence for patients with ischemic stroke than the Conservative Therapy The present study wishes to bring evidence that Vojta Therapy is superior in regaining functional independence for patients with ischemic stroke, whether it is solely used in the intervention, or as a complementary tool along with the Conservative Therapy. |
LUCACI DORU NICOLAE; | 2026-01-07 |
| 163 | A Prospective, First in Human Pivotal Study to Evaluate The Adaptive Tip Catheter Used to Treat Acute Ischemic Stroke Patients During Mechanical Thrombectomy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the safety and the effectiveness of the Adaptive Tip Catheter (ATC) used as a first line direct aspiration thrombectomy technique for patients suffering of an acute ischemic stroke. |
CHRISTOPHE COGNARD; | 2026-03-13 |
| 164 | EIT-Based Pulmonary Perfusion Pulse Wave Versus Swan-Ganz Catheter in Stroke Volume Correlation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical study is to learn if a new, non-invasive monitoring method called EIT Pulse Wave can accurately measure blood flow to the lungs (pulmonary perfusion) and predict heart stroke volume (SV) in critically ill patients. It will also learn about the safety of this monitoring approach. The main questions it aims to answer are: How well does the EIT Pulse Wave measurement of lung blood flow correlate with the SV measured by the standard method (Swan-Ganz catheter)? Can we build a reliable model to predict SV non-invasively using the EIT Pulse Wave signal? Researchers will compare the EIT Pulse Wave measurements directly with the Swan-Ganz catheter measurements to see if the new method is accurate. Participants will: Be critically ill adults in the ICU who are already receiving mechanical ventilation and have a Swan-Ganz catheter in place for medical reasons. Undergo simultaneous monitoring using both the EIT device and the Swan-Ganz catheter every 30 minutes for up to 48 hours. Have their ventilator settings adjusted to different levels as part of the study protocol while both measurements are recorded. |
UNION HOSPITAL TONGJI MEDICAL COLLEGE HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY | 2026-02-04 |
| 165 | Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Expanding evidence-based interventions for hypertension and stroke prevention among youth and their caregivers is crucial for meeting World Health Organization and Nigerian health goals. Innovative strategies are urgently needed to address the burden of hypertension and stroke in Nigeria, aiming to involve local communities, bridge generational gaps, and reduce health disparities. This study aims to determine the effect of a music-inspired intervention and campaign (Music4Health) designed by the community on blood pressure, stroke preparedness and intentions, and uptake of the intervention among youth-caregiver dyads in Nigeria. |
JULIET IWELUNMOR; | 2026-03-04 |
| 166 | Effects of Butylphthalide Enhanced With Tenecteplase on Neurological Function in Mild Disabling Acute Ischemic Stroke -A Prospective, Multicenter, Randomized, Double-blind, Active-controlled Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Abstract Background Intravenous thrombolysis is the cornerstone of early treatment for acute ischemic stroke (AIS), but some still have a poor prognosis, especially in patients with mild disabling stroke. Tenecteplase (TNK), a novel thrombolytic agent with favorable pharmacokinetic profiles, and butylphthalide (NBP), a multi-targeted neuroprotective drug, have shown promising efficacy in separate clinical applications. However, … |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2026-02-12 |
| 167 | Controlled Arterial Protection to Ultimately Remove Embolic Material PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to demonstrate safety and efficacy of the EmStop Embolic Protection System when used as indicated to capture and remove thrombus/debris during self-expanding transcatheter aortic valve replacement (TAVR) procedures. |
STANLEY J CHETCUTI; | 2026-01-30 |
| 168 | A Multicenter, Double-blind, Randomized, Placebo-controlled Study of The Efficacy and Safety of The Recombinant Non-immunogenic Staphylokinase in Patients With Acute Ischemic Stroke Within 4.5-24 Hours of Symptom Onset (FRIDA-CT) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Multicenter, double-blind, randomized, placebo-controlled phase III clinical trial. At the clinical sites, patients with acute ischemic stroke within 4.5-24 hours of symptom onset will be randomized to receive a single bolus injection of the recombinant non-immunogenic staphylokinase (Fortelyzin®, LLC SuperGene, Russia) or placebo. |
NIKOLAY A. SHAMALOV; | 2026-01-08 |
| 169 | Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection: Study Protocol for A Multicenter, Three-arm, Open-label, Randomized, Parallel-controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China. All patients receive total arch replacement (TAR) combined with frozen elephant trunk (FET) implantation and are randomized to Group 1 (arch-clamping technique under mild hypothermia), Group 2 (arch-clamping technique under moderate hypothermia) and Group 3 (Sun’s procedure using bilateral antegrade cerebral perfusion) in the ratio of 1:1:1. After a 1-year follow-up, … |
JUNMING ZHU; | 2025-12-15 |
| 170 | Efficacy and Safety of Tirofiban Therapy in Acute Ischemic Stroke Patients Beyond The Time Window Guided By High-Resolution Magnetic Resonance Imaging PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to address the existing clinical challenges by introducing high-resolution magnetic resonance vessel wall imaging (HR-MRI), an advanced imaging technology, to achieve precise etiological classification in patients with acute ischemic stroke (AIS) beyond the time window. HR-MRI allows clear visualization of intracranial arterial wall structures and direct identification of key pathological features of the culprit vessel, including atherosclerotic plaques, vascular wall remodeling, and intracranial hemorrhage, thereby enabling reliable differentiation between intracranial atherosclerotic large artery atherosclerosis (ICAS-LAA) stroke and other etiological subtypes such as cardiogenic embolism. Based on the latest clinical demands and advances in imaging technology, … |
WEILI LI; | 2026-02-04 |
| 171 | Pivotal Randomized Study of The SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to assess the safety and efficacy of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing HRPCI. Eligible patients will be randomized to undergo HRPCI with either the Supira System (investigational device) or the commercially available Impella systems (comparator device). |
SUPIRA MEDICAL | 2026-02-10 |
| 172 | Screening for Intracranial Unruptured Aneurysms in First-Degree Relatives of Patients With Aneurysmal Subarachnoid Hemorrhage PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms. This study aims to identify individuals who are at increased risk and determine the effect of environmental factors for development of unruptured intracranial aneurysms. |
NEBOJSA LASICA; | 2026-02-04 |
| 173 | Evaluation of The Efficacy and Safety of Hyperbaric Oxygen in Patients After Endovascular Treatment for Acute Ischemic Stroke: A Multicenter, Open-label, Randomized Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2. The main questions it aims to answer is: Whether HBO can improve the prognosis of ischemic stroke patients after endovascular treatment? 3. Participants will: receive HBO (1.6 Atmosphere Absolute，1.6ATA)，Once a day, for 1 hour each time, for 5 days a week (it can be non-consecutive days), the total course of treatment is 10 times. undergo three scheduled face to face or telephone follow-up assessments during the 12-month period following HBO. |
JING YANG; | 2025-12-31 |
| 174 | DIROXIMEL FUMARATE TO REDUCE PERIHAEMATOMAL OEDEMA IN INTRACEREBRAL HAEMORRHAGE: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL (DARLENE) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Spontaneous intracerebral haemorrhage (ICH) is a life-threatening condition, still devoided of specific treatment. Peri-haematomal oedema (PHO) develops in the ensuing days after ICH onset and worsens functional outcome. Hence, PHO is a promising therapeutic target but until now there is no specific treatment for PHO. The occurrence and growth of PHO is mainly mediated by inflammation. We hypothesize that a modulation of inflammation is effective in reducing PHO growth, therefore improving the functional outcome of ICH patients. From animal studies to human post-mortem studies, our team has demonstrated a key role for erythroid-related nuclear factor 2 (Nrf2) in PHO. Indeed, … |
UNIVERSITY HOSPITAL LILLE | 2025-12-18 |
| 175 | INtensive LiPid-lowering Therapy for Acute High-risk IntracRanial or Extracranial AtheroSclerosis -II (INSPIRES-2)：A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The research team is conducting a randomized, double-blind, placebo-controlled, multicenter clinical study aimed at evaluating the impact of adding Tolecilimab (a PCSK9 inhibitor) to standard lipid-lowering therapy (statins ± ezetimibe) on serum lipoprotein(a) \[Lp(a)\] levels and the risk of stroke recurrence within 90 days in patients with ischemic stroke or high-risk TIA (ABCD² ≥ 4) accompanied by elevated lipoprotein(a) levels (≥50 mg/dL). |
YILONG WANG; | 2026-01-15 |
| 176 | Prevalence of Cerebral Large Vessel Occlusion Among Acute Ischemic Stroke Patients in Assiut University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals 1. Study Objectives Primary Objective: \- To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals Secondary Objectives: * To describe clinical and radiological characteristics of LVO patients. * To assess factors associated with LVO (age, sex, stroke severity, comorbidities). 2. Study Design * Type: single center, prospective observational cross-sectional study * Duration: 12-month recruitment period * Setting: Assiut university hospitals, … |
AHMAD TAREK ALY SAYED; | 2026-01-08 |
| 177 | Augmenting Cerebral Blood Flow Using A Novel Combined Treatment Approach in Patients With Ischemic Stroke: Protocol Development PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The most common type of stroke is ischemic (lack of blood flow to the brain due to a clot blocking a blood vessel). Time is brain and an average of 1.9 million brain nerve cells per minute are destroyed in patients experiencing a typical LVO. The main goal of treatment is to help restore blood flow as quickly as possible and prevent brain tissue and cell death. Acute treatments like clot-busting medication or clot removal by wire are standard of care but are available in comprehensive stroke centers in a few urban centers. Often, … |
MAHESH KATE; | 2026-01-06 |
| 178 | Evaluation of Occlusal Adjustment Material Removal on Monolithic Zirconia Blocks: An In Vitro Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to improve understanding of the amount of tooth-replacement material removed during a single grinding stroke performed in the adjustment of a zirconia crown. Zirconia is a highly durable ceramic material commonly used for dental restorations, and accurate adjustment is essential for achieving proper occlusion. However, existing literature does not provide quantitative data regarding material removal per stroke during chairside adjustment, resulting in reliance on individual clinical experience. In this study, standardized zirconia specimens will be prepared and assigned to three operator groups: dental students, dental interns, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2025-12-30 |
| 179 | Validation of New SEMG Electrode Placement Guidelines for The Triceps Surae in Post-stroke Individuals PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background and rationale: Surface electromyography (EMG) is a non-invasive method to measure muscle activity, among others in people after a stroke during gait analysis. Measurement quality is strongly influenced by electrode placement. However, the commonly used SENIAM guidelines do not take individual variations in muscle morphology into account, which can lead to inaccurate measurements. In previous research (De Vlieger et al. 2025, Journal of Electromyography and Kinesiology), we demonstrated that the standard placement on the triceps surae (medial and lateral gastrocnemius and soleus) was suboptimal at the group level and sometimes even problematic at the individual level. Therefore, … |
UNIVERSITY HOSPITAL GHENT | 2026-02-04 |
| 180 | Early Feasibility Study of The Append System for Left Atrial Appendage (LAA) Elimination By Invagination and Ligation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This early feasibility study is intended to evaluate the safety and feasibility of the Append System for eliminating the left atrial appendage (LAA) through a transcatheter procedure that invaginates and ligates the LAA tissue. |
VIVEK REDDY; | 2025-12-17 |
| 181 | The Effects of Intensive Virtual Reality-Based Balance and Gait Training on Activity Performance and Quality of Life in Individuals With Subacute Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is one of the leading causes of long-term disability worldwide, and balance and gait impairments are common in the subacute phase, limiting activity performance and quality of life. Early and intensive rehabilitation during the first six months after stroke is considered critical for optimizing functional recovery. Virtual reality-based rehabilitation has emerged as a promising approach to enhance motor learning through task-specific, repetitive, and feedback-driven training. This randomized controlled trial aims to investigate the effects of intensive virtual reality-based balance and gait training on activity performance, balance confidence, … |
MURAT AKINCI; | 2026-03-27 |
| 182 | The Safety and Effectiveness of Q Therapeutic System, Frequency-tuned Electromagnetic Field Treatment in Facilitating The Recovery of Patients With Chronic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This trial will test a promising new intervention to promote post-stroke neural reorganization and functional recovery. The overall aim is to identify a systematic, methodological approach to system fitting, training protocols, and optimization of collecting outcome measures. Aim 1: Assess the safety of using the Q Therapeutic (BQ 3.0) System, including in-clinic and at- extremity rehabilitation training for individuals with chronic stroke, … |
GHAITH J. ANDROWIS; | 2026-03-30 |
| 183 | Effects of Repetitive Transcranial Magnetic Stimulation Combined With Motor Rehabilitation on Motor and Functional Outcomes in Patients With Ischemic Stroke: A Randomized Sham-Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Ischemic stroke is a leading cause of long-term motor disability, frequently resulting in hemiplegia and limitations in daily activities and quality of life. Motor rehabilitation is a fundamental component of post-stroke care across all stages of recovery; however, functional outcomes may vary, … |
LOAN PHAN THI KIEU; | 2026-02-10 |
| 184 | Menopausal Hormone Therapy And Neural Control Of Left Ventricular Function PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to compare left ventricular stroke volume and heart rate responses to bursts of SNA between PMF using, and not using, MHT. |
JOSHUA M. BOCK; | 2026-01-21 |
| 185 | The Role and Mechanism of Distant Ischemic Adaptation in Improving Cognitive Impairment in Cerebral Infarction and Cerebral Small Vessel Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebral infarction (ischemic stroke) and cerebral small vessel disease (CSVD) represent major global causes of disability, cognitive decline, and mortality. Despite advances in reperfusion therapies, many patients experience residual neurological deficits and remain at high risk for recurrent stroke and vascular dementia. Effective adjunctive treatments that are safe, accessible, and capable of improving long-term outcomes are urgently needed. Distant ischemic adaptation (also known as remote ischemic conditioning, RIC) is a non-invasive, safe, and cost-effective intervention that induces endogenous protection against ischemic injury by applying brief, intermittent ischemia to a remote limb. While several large-scale clinical trials (e.g., RICAMIS, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2026-03-31 |
| 186 | Effects of Web-Based Physical-Cognitive Telerehabilitation Exergaming on Physical and Cognitive Performance in Chronic Stroke Survivors: Protocol for A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if a web-based exercise and cognitive training (physical-cognitive) program works to improve movements and brain function in adults with long-term stroke. It will also learn whether the program is safe and enjoyable. The main questions it aims to answer are: Does the program improve walking, balance, strength, and reduce fall risk? Does the program improve cognitive skills such as memory, attention, … |
SOMPORN SUNGKARAT; | 2026-03-03 |
| 187 | IWalk in VR: Integration of Virtual Reality-based Locomotor Rehabilitation in Clinical Care PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to: (1) implement and test the feasibility of a new VR-ODT intervention offered as part of usual therapy time of patients with a sub-acute stoke; (2) explore the acceptability of the intervention from the perspective of clinicians and patients and; (3) implement measures to optimize the uptake and sustainability of the intervention within the clinical setting. Participants will engage in a personalized VR-ODT training for 4 weeks (2X 1hr/week) targeting six well-established community walking demands related to (1) walking speed and (2) distance; (3) postural transitions; (4) obstacle avoidance; (5) dual-task walking and; … |
ANOUK LAMONTAGNE; | 2026-03-20 |
| 188 | Comparison of The Effectiveness of TENS and TENS + NMES Treatment in Stroke Patients With Shoulder Pain: Prospective Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, the effects of Transcutaneous Electrical Nerve Stimulation (TENS) and Neuromuscular Electrical Stimulation (TENS + NMES) applied in addition to TENS on pain, shoulder joint range of motion and upper extremity functions will be comparatively evaluated in stroke patients with hemiplegic shoulder pain. In this direction, in the study; The effectiveness of both treatment approaches on the severity of hemiplegic shoulder pain, their contribution to shoulder functionality and daily living activities will be examined; It will be investigated whether NMES application added to TENS provides an additional clinical benefit compared to TENS. |
SEVINÇ KÜLEKÇIOĞLU; | 2026-01-20 |
| 189 | REVascularization In Large VEssel Occlusion for Acute Ischemic Stroke Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to evaluate the safety and effectiveness of the SOFIA Flow 88 Aspiration Catheter for treatment of acute ischemic stroke. |
MICHAEL HILL; | 2026-03-27 |
| 190 | Intravenous RhPro-UK Versus Placebo Before Endovascular Thrombectomy For Stroke Patient With Large Vessel Occlusion In The Extended Time Window: The Randomized, Placebo-controlled, Double-blind Trial (BRIDGE-PUK EXTEND ) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human Prourokinase (rhPro-UK) in acute ischemic stroke patients with large vessel occlusion presenting 4.5-24 hours after last known well. The study will address two primary questions: 1) Whether rhPro-UK enhances pre-thrombectomy reperfusion rates and improves 90-day functional outcomes compared to placebo; 2) Whether rhPro-UK increases the risk of symptomatic intracranial hemorrhage and mortality. Participants will be randomized to receive an intravenous bolus of rhPro-UK or matching placebo, with a total dose of 35mg (15mg administered as an intravenous push within 5 minutes, … |
FIRST AFFILIATED HOSPITAL XI’AN JIAOTONG UNIVERSITY | 2026-02-05 |
| 191 | Clinical Study on The Safety and Efficacy of Human Adipose-Derived Stem Cell Exosomes in The Treatment of Acute Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase I/II, randomized, double-blind, placebo-controlled, single/multiple ascending dose clinical study (Investigator-Initiated Trial, IIT) evaluating the safety and efficacy of Human Adipose-Derived Stem Cell Exosomes (ADSC-exo, STX11102 Nasal Spray) in treating acute ischemic stroke (AIS). The study consists of two sequential parts: a Single-Ascending Dose (SAD) study and a Multiple-Ascending Dose (MAD) study. The SAD part will enroll 12 subjects with mild stroke (NIHSS 1-4). They will be sequentially enrolled into three dose cohorts (4 subjects each: 2×10⁹, 4×10⁹, and 8×10⁹ particles/mL) to receive a single nasal spray dose alongside standard care, … |
YUNCHENG WU; | 2026-02-10 |
| 192 | Efficacy and Safety of Methylprednisolone in Preventing Adverse Cerebrovascular Events After Flow-Diverter Stent Implantation in Patients With Unruptured Intracranial Aneurysms: A Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Study Title: Testing Methylprednisolone to Prevent Strokes After a Stent Procedure for Brain Aneurysms What is the purpose of this study? This study aims to find out if a short course of a steroid medicine called methylprednisolone can help prevent strokes and other brain-related complications in patients who have a flow diverter stent placed to treat an unruptured brain aneurysm. The main goal is to see if this treatment reduces the combined number of new strokes (both clot-related and bleeding-related) or brain injury-related deaths within the first 30 days after the procedure. Who can participate? Adults aged 18 or older with an unruptured brain aneurysm (size 3-25mm) who are scheduled to receive a flow-diverting stent and can provide informed consent may be eligible. Key reasons someone might not be able to join include: having multiple aneurysms needing quick treatment, being pregnant or breastfeeding, having a history of recent stroke, having active infections or stomach ulcers, having severe kidney disease, having very high/uncontrolled blood pressure or blood sugar, or already being on long-term steroid therapy. What will happen in the study? This is a multicenter, randomized, double-blind study. This means: Participants will be randomly assigned (like flipping a coin) to one of two groups. One group will receive methylprednisolone. The other group will receive a placebo (an inactive substance that looks identical). Neither the participants nor their doctors will know which treatment is being given. All participants will receive the standard care for the stent procedure and aftercare. How long will the study last? The treatment period is short (around the time of the procedure). Participants will be closely monitored in the hospital and will have a follow-up visit around 30 days after the procedure to check their health status. What will be measured? The researchers will mainly track whether participants have any stroke or brain injury-related death in the first 30 days. They will also check for other complications like bleeding, infections, and changes in daily function and quality of life. Safety will be monitored throughout. How many people will take part? The study plans to enroll approximately 864 participants across multiple hospitals. Study Dates: The study is expected to start enrolling patients in January 2026 and finish in August 2027. Who is organizing the study? This study is sponsored and led by Zhujiang Hospital, Southern Medical University. |
DUAN CHUANZHI; | 2026-01-20 |
| 193 | Post-discharge Nurse-led Rehabilitation to Improve Functional Activity and Community Participation Among Stroke-Patients in Bangladesh: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke causes various levels of disability which decreases physical function for a prolonged period. The purpose of this study is to evaluate the effectiveness of a nurse-led rehabilitation program including a multidisciplinary team focused on improving the functional ability among post-stroke patients in Bangladesh. A prospective, open-label (1:1) randomized controlled trial (RCT) will be conducted at the National Institute of Neuroscience \& Hospital (NINS\&H) in Dhaka, … |
SALMA AKHTER; | 2026-02-03 |
| 194 | Comparison of The Amplatzer Amulet Versus LAmbre Device for Left Atrial Appendage Closure: The CALAMBRE Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Clinical investigation with CE-marked medical devices, multicenter, prospective, randomized and controlled. Patients with non-valvular atrial fibrillation at high embolic risk and with at least one high bleeding risk criterion according to the Munich consensus document will be randomized to left atrial appendage closure with either the Amplatzer Amulet™ or the LAmbre™ device. The study is designed to compare the efficacy and safety of both devices regarding successful implantation, effective appendage closure, and clinical outcomes at follow-up. |
FUNDACIÓN EPIC | 2025-12-03 |
| 195 | Efficacy and Safety of Intra-Arterial Albumin As Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke: A Multicenter, Prospective, Open-Label, Endpoint-Blinded, Randomized Controlled Clinical Trial (AMASS2) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke remains a predominant global public health challenge, ranking as the third leading cause of death and the fourth leading contributor to disability-adjusted life years (DALYs). According to the Global Burden of Disease Study 2021, there are approximately 93.8 million prevalent stroke cases and 11.9 million new cases worldwide. China bears one of the heaviest burdens, with over 2 million new cases annually. Acute ischemic stroke (AIS), caused by acute cerebrovascular occlusion, accounts for 80% of all strokes. Approximately 30% of AIS cases result from large vessel occlusion (LVO), … |
MING WEI; | 2026-01-26 |
| 196 | Registry of Daprodustat in Chronic Kidney Disease (CKD) Anemia for Understanding Real-World Evidence (REDCURE) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A local registry on CKD-associated anemia aims to provide real-world insights into disease burden, treatment patterns, and outcomes at the national level. It helps capture variations in anemia severity with CKD stages, therapeutic practices and their response. It also supports evidence-based decision-making, identifies gaps in care, and informs locally relevant guidelines and policy planning to improve patient outcomes with oral novel therapy i.e. daprodustat |
NABIQASIM INDUSTRIES PVT | 2026-01-20 |
| 197 | The Effect of Percussion Massage Therapy on Muscle Tone, Walking and Balance Functions in Chronic Stroke Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is an acute neurological condition resulting from cerebral ischemia or hemorrhage, frequently leading to impaired motor function, increased muscle tone, and deficits in balance and gait. Spasticity is a common long-term complication in individuals with chronic stroke and significantly affects functional mobility and quality of life. Percussion Massage Therapy (PMT) is an emerging intervention that combines principles of mechanical vibration and traditional soft tissue techniques. Although previous research has examined its effects in musculoskeletal and athletic populations, … |
HAKAN POLAT; | 2026-03-06 |
| 198 | Effects of Posture-Oriented Kinesio Taping on Mobility, Balance, Coordination, and Activities of Daily Living in Patients With Stroke: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke often leads to postural asymmetry and impaired trunk control, which negatively affect mobility, balance, coordination, and activities of daily living. These impairments increase the risk of falls and reduce functional independence during the rehabilitation process. The purpose of this randomized controlled trial is to investigate the effects of posture-oriented kinesio taping, applied in addition to standard neurological rehabilitation, on functional outcomes in patients with stroke. Participants will be randomly assigned to either an intervention group receiving kinesio taping plus standard rehabilitation or a control group receiving standard rehabilitation alone. Functional outcomes including trunk control, postural stability, balance, mobility, … |
TANER DANDINOĞLU; | 2026-01-13 |
| 199 | The Impact of An Advance Care Planning Game on Life-Sustaining Treatment Preferences, Depression, and Hope in Older Adults With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is the world’s third leading cause of death and a major source of disability, with high rates of recurrence and mortality that often limit patients’ ability to express their values and treatment preferences. This highlights the importance of Advance Care Planning (ACP) after stroke. This randomized controlled trial examined the effects of an ACP block-based game on life-sustaining treatment preferences, depression, and hope among adults aged 65-100 with subacute stroke in a regional teaching hospital. The Life Support Preferences Questionnaire (LSPQ) served as the primary outcome to assess preference changes immediately after the intervention and at four weeks, … |
YU-CHUN CHIEN; | 2026-02-04 |
| 200 | Comparative Effectiveness of Dulaglutide, Semaglutide, and Tirzepatide in Preventing Cardiovascular Events in Patients With Type 2 Diabetes and Obesity With or Without Atherosclerotic Cardiovascular Disease PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials. The investigators’ goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies. |
SHIRLEY VICHY WANG; | 2026-02-18 |