Clinical Digest: Recent Clinical Trials on Asthma (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Asthma. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Asthma (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | A Multicenter Observational Study on The Current Status of Control and Treatment of Outpatient Children With Asthma and The Types of Airway Inflammation PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to comprehensively understand the disease control and management status of children with asthma in China, as well as the types of airway inflammation. The findings of this survey will help improve the asthma control level in Chinese children, facilitate future patient education, and guide rational medication use. Moreover, it will provide important evidence for health decision-making departments to better allocate and utilize medical resources. |
KUNLING SHEN; | 2026-02-17 |
| 2 | A Randomized, Multicenter, Multiple-dose, Double-blind, Placebo-controlled, Parallel-group Design, Clinical Endpoint Bioequivalence Study to Evaluate The Therapeutic Equivalence and Safety of Fluticasone Furoate and Vilanterol Inhalation Powder 100 Mcg/25 Mcg (Sandoz) and BREO® ELLIPTA® (Fluticasone Furoate and Vilanterol Inhalation Powder) 100 Mcg/25 Mcg (GlaxoSmithKline) in Adult Participants With Asthma PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, multi-center, multiple-dose, double-blind, placebo-controlled, Parallel group design, clinical endpoint bioequivalence study in adult participants with asthma. The study design includes up to a 2-week Screening period, at least a 2-week Run-in period, a 4-week Treatment period, … |
SANDOZ | 2026-02-05 |
| 3 | Giving Asthmatics Intramuscular Steroids for Preventing Return to The Emergency Department: A Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the efficacy of a one-time IM dose of dexamethasone versus a 5-day course of prednisone in adult ED patients presenting with asthma exacerbations. This is a randomized, controlled, double-blind, non-inferiority trial conducted at two urban EDs within the Montefiore Health System. |
CARLO LUTZ; | 2026-03-09 |
| 4 | Research on Disease Control and Mental Health Status of Adolescent Asthma Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Currently in China, adolescent asthma care is characterized by both undertreatment and overtreatment. Patients in this age group may exhibit negative emotions toward disease treatment and long-term control. Insufficient disease knowledge, irregular lifestyle habits, and negative attitudes toward the disease can all reduce medication adherence, affect disease control outcomes, and thereby increase the risk of severe chronic respiratory conditions and disease burden in adulthood. Objectives: To assess disease control status in adolescent asthma patients, evaluate the psychological well-being of patients and their family members, … |
KUNLING SHEN; | 2026-02-17 |
| 5 | Tezepelumab in The Treatment of Emergency Room Asthma in Adults (TERAA): A Phase 4 Double-Blinded, Parallel-Group, Randomized Control Trial With An Open Label Extension PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Adults with severe asthma may have sudden worsening shortness of breath that results in their going to Emergency Department for urgent care. Emergency Room visits for asthma management across Alberta have been reviewed and it has been found that adults frequently need to return for repeated worsening. This is a large drain on health care resources as well as being very distressing for individuals with asthma. Occasionally this results in admission to hospital and rarely may lead to death. People are often treated with steroids to try to prevent the need for Emergency Room visits even though steroid medications have many long term bad side effects. A new medication for patients considered to have severe asthma has been recently approved by Health Canada. This medication, Tezepelumab, is a monthly injection and it helps control asthma in adults regardless of the underlying cause. The study will examine if starting Tezepelumab, compared with a placebo, in the Emergency Room will help settle symptoms of asthma and prevent future worsening requiring repeated Emergency Room visits or the need for courses of outpatient steroid medications. |
IRVIN MAYERS; | 2026-03-13 |
| 6 | Ventilation and Perfusion in Individuals With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation (V-distribution), ventilation defect percentage (VDP), and ventilation heterogeneity (VH). |
TRISHUL SIDDHARTHAN; | 2026-03-16 |
| 7 | Design, Development and Evaluation of A Digital Health Assistant for Paediatric Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is to evaluate the efficacy of the digital health assistant (DHA) Alex in improving asthma control in asthmatic children and adolescents aged 10 to 19 compared to their baseline values. It is designed to track over a period of six consecutive months lung function parameters, lung inflammation, asthma symptoms and burden, medication adherence, and passively recorded nocturnal asthma symptoms and markers related to sleep quality. In Phase I (months 1-3), Digital Health Assistant (DHA) ‘s core functionality will be deployed. In Phase II (months 3-6), the platform will be augmented with lung-function-fluctuations analysis-informed therapeutic recommendations, … |
EDGAR DELGADO-ECKERT; | 2026-03-16 |
| 8 | The Effect of Acupuncture on Pulmonary Function Recovery Following Lung Resection: A Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background and Purpose: Lung resection surgery is the standard treatment for early-stage lung adenocarcinoma, but it often leads to reduced lung volume and postoperative pain, which can hinder pulmonary recovery. While standard rehabilitation includes breathing exercises (incentive spirometry) and pain management, additional strategies are needed to enhance recovery. Acupuncture has shown benefits in managing respiratory diseases like COPD and reducing surgical pain, … |
CHUNG SHAN MEDICAL UNIVERSITY | 2026-03-02 |
| 9 | Multi-component Package for Skin Health and Allergen Exposure Strategy to Prevent Food Allergy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine if a multi-component environmental package (MEP) can prevent food allergies among infants at risk of developing food allergies in early life. Researchers will compare the multi-component environmental package to regular care to see if the MEP works to prevent food allergies. Participants will: * Be assigned to the multi-component environmental package or regular care once their baby is born * Complete a weekly diary * Attend in-office visits at 4 and 12 months of age * Complete web-based questionnaires at 4, 6, 9 and 12 months of age |
DEREK CHU; | 2026-03-23 |
| 10 | Novel Strategies to Improve Housing Quality and Respiratory Health for Low Socioeconomic Status Children With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this intervention study is to assess the effectiveness of low-cost humidity and mold reduction interventions in the home for reducing pediatric asthma. The study will have two groups, a treatment group that receives the healthy home interventions during the study and a second control group that will receive these after the study. We will compare pediatric asthma before and three months after the healthy home interventions are performed. |
BRIDGET HEGARTY; | 2026-03-13 |
| 11 | PREDICT: A Prospective, Multicenter Real-World Study to Describe The Clinical Outcome and Quality of Life in Chinese CRSwNP Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, multicenter real-world study to describe the postoperative outcomes and quality of life, disease control and characteristics of patients who underwent surgery, as well as economic burden and post-operative treatment patterns in Chinese patients with CRSwNP recurrence. |
WEIPING WEN; | 2026-03-03 |
| 12 | ROSY-F: Roll-Over Study for Participants Who Have Completed A Previous Study With Benralizumab (Fasenra) and Are Judged By The Investigator to Clinically Benefit From Continued Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The rationale of the roll-over study (ROSY) is to provide continuous access to study treatment for participants who have completed or exited a parent study and are deemed appropriate for continued benralizumab treatment, as judged by the Investigator, while monitoring long-term safety and tolerability of benralizumab. |
ASTRAZENECA | 2026-03-03 |
| 13 | A Multi-center, Open-label, Phase II, Single-arm Clinical Study Evaluating The Safety and Efficacy of TQH2722 Injection Combined With Background Treatment in Subjects With Seasonal Allergic Rhinitis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multicenter, open-label, Phase II, single-arm clinical trial, with a planned enrollment of 200 to 300 subjects. Its primary objective is to evaluate the safety and efficacy of TQH2722 injection in the treatment of seasonal allergic rhinitis. |
SHANGHAI CHIA TAI TIANQING PHARMACEUTICAL TECHNOLOGY DEVELOPMENT | 2026-03-27 |
| 14 | The Effect of Preoperative Nebulized Lidocaine and Nebulized 3% NaCl Premedication on Postoperative Respiratory Complications in Pediatric Patients Undergoing Adenoidectomy And/or Adenotonsillectomy Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective, randomized clinical trial aims to evaluate the effect of preoperative nebulized lidocaine and nebulized 3% hypertonic sodium chloride (NaCl) on the incidence of postoperative respiratory complications in pediatric patients undergoing adenoidectomy and/or adenotonsillectomy. Lidocaine, a versatile sodium channel blocker, has shown antitussive, bronchodilatory, and anti-inflammatory benefits when nebulized, and has been safely used in children for respiratory procedures. Hypertonic 3% NaCl is known to improve mucociliary clearance, reduce airway edema, and enhance secretion mobilization, particularly in pediatric respiratory conditions. Both agents have demonstrated individual safety and efficacy in respiratory management, … |
BURÇIN ALAÇAM; | 2025-12-05 |
| 15 | Open-label, Prospective, Crossover, Proof-of-concept Study to Evaluate The Effect of Triple Therapy With Extrafine Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrrolate (BDP/FF/G) Via PMDI Compared With Non-extrafine Fluticasone Furoate/Umeclidinium/Vilanterol (FluF/UMEC/VI) Via DPI on Lung Ventilation and Clinical Outcomes in Subjects With Moderate to Severe Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to enroll participants with uncontrolled asthma to evaluate the large and small airways and drug delivery utilizing two study drugs: * Beclometasone dipropionate/Formoterol fumarate dihydrate/Glycopyrronium bromide (BDP/FF/G) or Trimbow * Fluticasone furoate/Umeclidinium/Vilanterol (FluF/UMEC/VI ) or Trelegy Ellipta |
SURYA P BHATT; | 2026-02-12 |
| 16 | Eine Prospektive, Offene, Multizentrische, Nicht-interventionelle Studie Zur Erhebung Von Daten Zur Anwendung Von Grass MATA MPL 27 600 SU Und Compliance in Der Täglichen Klinischen Praxis Bei Erwachsenen Gräserpollen- Allergikern PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Objective of this non-interventional study (NIS) is to collect data on the use of Grassmuno® in routine clinical practice. |
ALLERGY THERAPEUTICS | 2026-03-20 |
| 17 | Early Effects of Different Inspiratory Muscle Training on Disease Clinical Course, Respiratory Parameters, Functional Capacity and Quality of Life in Patients With COPD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: COPD is one of the most life-threatening pulmonary diseases. According to the World Health Organization, it is expected to rise to the third leading cause of death by 2030. Smoking is the most significant contributing factor. COPD reduces lung volumes and causes dyspnea. Over time, respiratory muscle weakness develops, leading to hypercapnia, dyspnea, nocturnal oxygen desaturation, … |
ERDİ KAYABINAR; | 2026-03-16 |
| 18 | A Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate The Efficacy and Safety of RC1416 Injection in Adult Patients With Moderate to Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a phase II study of RC1416 in subjects with severe uncontrolled asthma. The purpose of the study is to evaluate efficacy and safety of RC1416 in subjects with severe uncontrolled asthma. |
NANJING REGENECORE BIOTECH | 2026-02-11 |
| 19 | Efficacy of Behavioral Therapy for Chronic Refractory Cough in Patients With Laryngeal Hyperresponsiveness PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic cough is defined as cough persisting for more than eight weeks. It is a common clinical problem that significantly impairs patients’ physical, psychological, and social quality of life. Chronic cough remains a diagnostic and therapeutic challenge despite systematic evaluation and treatment of common etiologies such as asthma, gastroesophageal reflux disease |
MOHAMED SHAABAN MOHAMED; | 2026-03-23 |
| 20 | Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, controlled study. ACS follow- up patients aged 18 to 80 years old with hemodynamic stability, who are 14 days to 1 year after PCI, are screened through the HAMD score and the HAMA score. Patients with a HAMD score greater than 7 points and a HAMD score higher than that of the HAMA, are included in this study. Patients were allocated to the active taVNS group or sham taVNS group with a 1:1 ratio. Both groups received the stimulation for 20 minutes each time, … |
JING HAN; | 2026-03-06 |
| 21 | The MODIFY Study: A Phase 3b/4 Randomized, Double-blind, Placebo-controlled, Multi-centre Study Evaluating The Impact of Early Intervention With Depemokimab on Exacerbation Rate, Clinical Remission, Lung Function Decline, and Safety in Adults and Adolescents With at Risk Type 2 Asthma, Conducted Up to 156 Weeks PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the efficacy of depemokimab administered as an adjunctive therapy, in participants with Type 2 asthma at risk of exacerbations compared to the guideline recommended standard of care (SoC). |
GLAXOSMITHKLINE | 2026-03-06 |
| 22 | Safety and Efficacy Evaluation of Extensively Hydrolyzed Formula for Cow’s Milk Protein Allergy (CMPA) in Infants and Young Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, multi-center, randomized, open-label, active-controlled, parallel-group, non-inferiority study. The goal of this clinical trial is to evaluate the clinical efficacy and safety of an extensively hydrolyzed formula (eHF) in treating infants with mild-to-moderate cow’s milk protein allergy (CMPA). CMPA is a common condition in babies where the immune system reacts to proteins in cow’s milk, causing symptoms affecting the skin (such as eczema or hives), gastrointestinal tract (such as vomiting, diarrhea, or constipation), … |
HEILONGJIANG FEIHE DAIRY | 2026-03-19 |
| 23 | Safety and Preliminary Efficacy of Small Extracellular Vesicles (Code: HUC-MSC-sEV-002) Nebulizer in Patients With Allergic Rhinitis Complicated With Asthma: A Multicenter, Prospective, Randomized, Double-Blind Phase I/II Clinical Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This trial aims to evaluate the safety, tolerability and efficacy of hUC-MSC-sEV-002 nebulizer in patients with allergic rhinitis and asthma. It consists of two parts: ① Single-center dose exploration (The Affiliated Hospital of Qingdao University): A 3+3 escalation design will test three doses (1×10⁸, 1×10⁹, 1×10¹⁰ particles/mL) to determine the maximum tolerated dose (MTD).Three subjects will be enrolled in each dose group. If no Dose-Limiting Toxicity (DLT) is observed among the 3 subjects, the study may proceed to the next dose exploration. If 1 out of the 3 subjects experiences DLT, … |
YAN JIANG; | 2026-03-06 |
| 24 | Phase I Study to Compare The Pharmacokinetics of Budesonide and Formoterol Delivered With Symbicort Aerosphere® and Symbicort® PMDI in Children 4 to Less Than 12 Years of Age With Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the pharmacokinetics (PK) and safety of symbicort aerosphere and symbicort pressurized metered dose inhaler (pMDI) in participants with asthma aged 4 to less than 12 years. |
ASTRAZENECA | 2026-03-12 |
| 25 | A Comparative Study of Ultrasonic and Conventional Spirometers in Patients With Chronic Respiratory Diseases PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study compares a handheld ultrasonic spirometer with a standard hospital spirometer in adults with chronic respiratory diseases. Each participant will complete lung function tests using both devices. The study aims to determine whether the ultrasonic device provides accurate and reliable measurements for use in clinical or home settings. |
KE-YUN CHAO; | 2026-03-12 |
| 26 | A Randomized, Double-Blind, Placebo-controlled, Single- and Multiple-ascending Dose Study to Evaluate The Safety, Tolerability, Pharmacokinetics,Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in Healthy Volunteers and Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) and Comorbid Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a randomized, double-Blind, placebo-controlled, Single and Multiple-ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in Healthy Volunteers and Participants with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) and Comorbid Asthma. |
MIN WANG; | 2026-02-27 |
| 27 | A Pilot Randomised Controlled Trial (RCT) on The Effectiveness of Comics to Promote Tobacco-Related Knowledge, Attitudes and Behaviours Among Primary School Students PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pilot RCT is to evaluate the effectiveness of comics containing tobacco-related content in improving tobacco-related knowledge and attitudes among Hong Kong primary school students. The main questions it aims to answer are: * Is the intervention (i.e. comics) effective in improving tobacco-related knowledge (including alternative smoking products (ASPs) and tobacco control development in the world and Hong Kong) compared to controls (i.e. information sheets)? * Is the intervention (i.e.comics) effective in improving tobacco-related attitudes and intentions (including ASPs and tobacco control development in the world and Hong Kong) compared to controls (i.e. information sheets)? Researchers will compare the questionnaire results from students to see if intervention groups (students reading comics) will have better tobacco-related knowledge, higher anti-tobacco attitudes and lower intention to smoke compared to the control group (students reading information sheets). |
AU YEUNG; | 2026-03-09 |
| 28 | Online Cognitive Behavioural Therapy for Adolescents With Depression – A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background. Almost two thirds of adolescents experience a mental disorder before the age of 25. Among mental disorders, depression is one of the most common among young people aged between 15 to 24, with a prevalence of 13.5% to 15.8% worldwide and 13.2% in Hong Kong, which is alarming. Cognitive behavioural therapy and online cognitive behavioural therapy has been shown to be effective on reducing depression. Also, online cognitive behavioural therapy has also been shown to be useful for people with mild to moderate depression. However, … |
CITY UNIVERSITY OF HONG KONG | 2026-02-09 |
| 29 | Multicomponent Breathlessness and Physical Activity Intervention in People With Moderate to Severe Asthma Using A Supported Digital Platform PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Treating breathlessness could help people with asthma have fewer symptoms and be more physically active. People with asthma report that it is important to deal with breathlessness during physical activity programs, … |
UNIVERSITY OF NEWCASTLE AUSTRALIA | 2026-02-19 |
| 30 | Dosing of Steroids for Acute Asthma Given in The Emergency Department – A Pilot Randomised Feasibility Trial of Dexamethasone in Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Steroids given by mouth are an important first line treatment for children presenting with asthma attacks. Dexamethasone is the steroid used in some emergency departments (EDs) because of the need for a single dose and as it is well tolerated. The dose of dexamethasone in treating asthma attacks is not clearly established. This study compares two different doses of dexamethasone in children presenting with an asthma attack. Investigators will compare the effect of two different doses in reducing the need for a repeat prescription of steroids for an asthma attack in the 2 weeks after the first treatment. The investigators will also look at how often children attend the ED or their GP after being given treatment as well as the acceptability to parents and children. Although this study may provide an answer to the question of whether the different doses have the same effect, the investigators believe that a larger study will be needed to provide robust generalisable evidence, as well as to ensure that the outcomes are truly what matters to parents, children and healthcare professionals. This study will provide valuable information to enable a larger study to be undertaken. |
JUDITH GILCHRIST; | 2026-02-11 |
| 31 | PremaBiom: Metatranscriptomics of The Respiratory Microbiome to Predict The Occurrence of Bronchopulmonary Dysplasia in Preterm Infants PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks. The main questions it aims to answer are: * What is the role of microbiome maturation in respiratory health (development of bronchopulmonary dysplasia, childhood asthma and viral respiratory infections) of preterm infants ? * Which environmental or health factors are involved in the maturation of the respiratory microbiome ? Participants will undergo follow-up from birth until 3 years of corrected age including nasal swabs, stool samples, and for some of them blood and milk sample. |
UNIVERSITY HOSPITAL CAEN | 2026-02-13 |
| 32 | The Effect of A Vegan Diet on Inflammatory and Immune Biomarkers in Adult Patients With Asthma and in Healthy Individuals: A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled study evaluates the effects of a balanced vegan diet compared with a balanced omnivorous diet on inflammatory and immune response markers and clinical asthma parameters in healthy adults and individuals with mild to moderate asthma, aged 18 to 50. Participants will follow assigned dietary plans for 12 weeks with dietitian support delivered via digital tools. |
MEDICAL UNIVERSITY OF GDANSK | 2026-03-18 |
| 33 | Effect of Acute Hypoxia on RIght VEntRicular Function. A Single-Center, Double-Blind, Randomized Controlled Cross-Over Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with asthma responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, … |
MONA LICHTBLAU; | 2026-02-24 |
| 34 | Game-Based Rehabilitation for Scapular Dyskinesia Among Frisbee Players PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Scapular dyskinesia (SD) is a disorder defined by aberrant scapular placement and movement, which can have a substantial impact on athletes’ performance, particularly those who participate in throwing sports like Frisbee. This study aims to investigate the prevalence of SD among Frisbee players in Malaysia, assess its effects on various aspects of athletic performance, and evaluate the effectiveness of gamified scapular rehabilitation exercises delivered via a mobile application. This study’s approach is divided into three unique phases, where phase one consists of a prevalence and impact assessment using a cross-sectional study design, … |
NITHIYAH MARUTHEY; | 2026-04-01 |
| 35 | A Structured Health Assessment in Frequent COPD Exacerbators: To Optimise Management, Identify Comorbidities and Prevent Oral Corticosteroid Related Harm PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Chronic obstructive pulmonary disease (COPD) is a serious lung condition and the third leading cause of death worldwide. People with COPD have sudden and distressing flare-ups (exacerbations). These can be triggered by infections or occur without a clear cause. Flare-ups often lead to hospital admission, can cause a lasting health decline, increase the risk of dying and are strongly liked to lower income. Sometimes, people are wrongly diagnosed with COPD, when they have a different health issue. Other diseases (like heart conditions) are common in people with COPD, … |
RUTH E SOBALA; | 2026-03-10 |
| 36 | A Randomized, Double-blind, Phase II Clinical Study to Evaluate The Efficacy and Safety of AK139 in The Treatment of Participants With Moderate to Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, double-blind phase II clinical study to evaluate the efficacy and safety of AK139 in the treatment of participants with moderate to severe asthma. |
AKESO | 2026-02-27 |
| 37 | Investigating The Impact of Early Time-Restricted Eating on Health Outcomes and Quality of Life in Adults With and Without Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to explore how early time-restricted eating (eTRE) – where all daily meals are eaten within a specific time window – affects health and quality of life in adults. The researchers will compare results between adults with mild, well-controlled asthma and adults without asthma (the control group). Participants can continue to eat their normal food; only the timing of meals will change. |
NOUF ALOTAIBI; | 2026-02-20 |
| 38 | Pollution Intervention to Impact Kids Asthma Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if adding Air Quality Index (AQI) information to asthma action plans works to improve asthma outcomes in children. It will also learn about children with asthma who report being more sensitive to outdoor air pollution. The main questions it aims to answer are: * Does adding either information about the EPA-AQI or commercial AQI improve asthma outcomes over time? * Are there changes in nasal gene expression in children with asthma who report they are more sensitive to outdoor air pollution? Researchers will compare EPA-AQI and the commercial-AQI groups to a control group to either AQI works to improve asthma. Participants will: * Receive standardized outdoor air pollution education and an asthma action plan * Provide nose and blood specimens * Have visits every 4 weeks for 48 weeks, 10 will be conducted by telephone calls and 3 visits will be in person. |
FRANZISKA ROSSER; | 2026-02-27 |
| 39 | Clinical Application Study of Chronic Obstructive Pulmonary Disease Screening Using Artificial Intelligence-Based Acoustic Features PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality worldwide, yet early detection remains challenging-especially in primary care settings where spirometry, the diagnostic gold standard, is often unavailable. This study aims to develop and validate a non-invasive, low-cost COPD screening tool based on artificial intelligence (AI) analysis of cough sounds. Using smartphone-recorded cough audio and clinical data from both COPD patients and non-COPD controls, the investigators will train and test an AI model to identify acoustic signatures associated with COPD. The model will be developed using a prospective cohort from Sir Run Run Shaw Hospital, … |
HUIQING GE; | 2026-03-25 |
| 40 | ALExSEM – Hypersensibilité Au Liquide Séminal : Qualité De Vie ALExSEM – Human Seminal Plasma Allergy: Quality of Life PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Human Seminal Plasma Allergy (HSPA) is a rare allergy with localized and/or generalized manifestations following exposure during unprotected sex. Its cause remains undetermined and is certainly underdiagnosed. It is an under-recognized cause of acute or chronic pain related to penetration and vaginal inflammation affecting sexually active women. To date, no quality-of-life questionnaire specific to this condition exists to demonstrate its impact on the physical, mental, and sexual health of patients. To try to highlight the suffering of these patients, non-specific sexual quality-of-life questionnaires exist and could be used, such as the Female Sexual Function Index (including questions on desire, arousal, … |
MARTINE MORISSET; | 2026-02-18 |
| 41 | Everyone Is A Hope Builder Project Study- Therapeutic Song-writing Program PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The research aims to investigate the effectiveness of the therapeutic song-writing program on young people with depressive symptoms. This study adopts a multicentre randomized control trial two arms research design. A randomised controlled trial will compare a typical 7-session therapeutic song-writing program with a waitlist-control group to determine whether the 7-session therapeutic song-writing program can produce better outcomes for young people with depressive symptoms, including improvement in depressive symptoms, self-stigma, self-esteem, … |
CITY UNIVERSITY OF HONG KONG | 2026-02-09 |
| 42 | NIHR Global Health Research Centre for Multiple Long-Term Conditions Pilot Study to Assess The Acceptability, Feasibility, Fidelity and Usability of A Co-designed Intervention to Improve Management of Multiple Long-term Conditions PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This observational, non-randomized, single-arm pilot study aims to assess the acceptability, feasibility, usability, and implementation fidelity of a co-designed multi-component digital health intervention to support the management of multiple long-term conditions (MLTCs) in Government primary health care settings. The study is conducted among adult patients with MLTCs attending rural primary health centres and the primary care providers (Medical officers and Staff Nurse) delivering services at these facilities in India and Nepal. The intervention comprises an electronic decision support system (EDSS) to facilitate evidence-based clinical decision-making, assisted telemedicine model to enable timely specialist consultations, … |
DORAIRAJ PRABHAKARAN; | 2026-02-10 |
| 43 | Evaluation of The Effect of Perioperative Recruitment Maneuver Practice on Lung Ultrasound Score and Mechanical Power in Pediatric Patients; A Prospective Randomized Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Pulmonary atelectasis is common during general anesthesia and increases the risk of hypoxemia, especially in pediatric patients. PEEP and recruitment maneuvers (RM) are effective in preventing atelectasis. Lung ultrasound is practical for diagnosis. Mechanical power refers to the amount of energy delivered to the lung by the ventilator; excessive mechanical power can cause lung injury. Limiting mechanical power may reduce postoperative complications. This study aimed to determine the effectiveness of recruitment maneuvers in preventing atelectasis using lung ultrasound during the intraoperative period, to examine the relationship between lung ultrasound scores and mechanical power, … |
ELIF KESKIN; | 2026-02-11 |
| 44 | Investigating The Relationships Between Body Composition, Waist/Hip Ratio, Peripheral Muscle Strength, and Cough Force in Healthy Young Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: Body mass index (BMI) is a key parameter used for obesity classification and the evaluation and monitoring of individuals’ health status. Obesity, described by the World Health Organization as a major global epidemic, remains one of the most significant preventable and manageable conditions contributing to increased risks of cardiovascular and metabolic diseases. In addition to BMI, anthropometric measurements such as the waist-to-hip ratio are crucial indicators for risk assessment. While numerous studies in the literature have addressed the detrimental effects of obesity on respiratory functions, … |
NAZIRE NUR YILDIZ; | 2025-12-31 |
| 45 | Validity and Reliability Study of The Turkish Version of The Brompton Breathing Pattern Assessment Tool (BPAT) in Individuals With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the validity and reliability of the Turkish version of the Brompton Breathing Pattern Assessment Tool (BPAT) in individuals with asthma. This study aims to determine whether the BPAT is a valid and reliable tool for assessing breathing patterns in Turkish-speaking asthma patients. The research question being addressed is: Is the Turkish version of the BPAT a valid and reliable tool for assessing breathing patterns in individuals with asthma? |
DILEK UNSAL; | 2026-03-05 |
| 46 | Artificially Intelligent Robot (AIR) Support for Pediatric Asthma Education PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this prevention study is to evaluate the design and usability of a newly developed asthma education protocol with the Human Support Robot (HSR) for children with asthma. |
CYNTHIA FORONDA; | 2026-03-16 |
| 47 | A Two-part Randomized, Double-blind Placebo Controlled Trial to Assess The Safety and Tolerability of Single and Repeat Ascending Intranasal Doses of RIG-101 in Healthy Participants Followed By Repeat Daily Administration in Adult Participants With Asthma [Part A] Followed By A Randomized Double-blind Placebo Controlled Part to Assess The Efficacy and Safety of RIG-101 in Adult Participants With Asthma Before and After Viral Challenge With Human Rhinovirus RV-A16 [Part B] PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Nested Phase 1-2 Trial of RIG-101 in Healthy and Asthmatic Participants Assessing Safety, Tolerability and Viral Challenge Efficacy |
RIGIMMUNE | 2026-03-23 |
| 48 | Examining The Effectiveness of An Exercise Program Combined With Ergonomic Training for Textile Workers: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Most studies in the literature focus on musculoskeletal disorders and pain levels in occupational groups with repetitive workloads, such as textile workers. However, due to the nature of the work environment, decreased respiratory function and postural disorders are also frequently observed in these individuals. There is no comprehensive study in the literature that combines respiratory exercises, posture training, and ergonomics training for textile workers. Therefore, this study will examine the effects of a regular exercise program implemented alongside ergonomics training provided to textile workers on respiratory parameters, musculoskeletal disorders, posture, functionality, pain levels, and fatigue intensity. |
BERNA ÇAĞLA BALKIŞLI; | 2026-02-13 |
| 49 | Is There A Benefit From Addition of Physical Exercise to Diet Restriction/Limitation in PCOS Women With Asthma? PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Women with polysyctic ovarian syndrome (PCOS) usually develop many complications including asthma. Nowdays, diet restriction combimed with phsyical exercises may improve both problems |
ALI MOHAMED ALI ISMAIL; | 2026-03-03 |
| 50 | A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Safety, Tolerability and Pharmacokinetics of HY6725 Following Single and Multiple Subcutaneous Doses in Healthy Participants PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn the safety, tolerability and pharmacokinetics of single and multiple doses of HY6725 in healthy adult participants. The main questions it aims to answer are: * How is the safety and tolerability following administration of single and multiple doses of HY6725 in healthy adult participants? * What is the PK character of HY6725 following administration of single and multiple doses of HY6725 in healthy adult participants? Researchers will compare HY6725 to a placebo (a look-alike substance that contains no drug) to see if HY6725 is safe and well tolerated. Participants will take HY6725 or a placebo once or twice in single dose group or multiple dose group. And will be follow-up until Day 150. |
PHILIP RYAN; | 2026-03-11 |
| 51 | Disrupting Noxious Synergies of Indoor Air Pollutants and Their Impact in Childhood Health and Wellbeing, Using Advanced Intelligent Multisensing and Green Interventions: An Interventional Study in A Sub-group of Schoolchildren PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to identify and assess in real time the impact of the combined action of various types of air and dust pollutants within a classroom on children’s health and quality of life, particularly regarding atopic/allergic diseases in children, and on potential exposure to pollutants at home. Participants will answer questionnaires regarding their health and medications, undergo allergy tests, perform non-invasive lung function tests and check blood oxygen levels. |
UNIVERSITY HOSPITAL MONTPELLIER | 2026-02-11 |
| 52 | Assessing Biological Aging in A Real-World Medical Weight Loss Program Using The LinAge2 Clinical Clock PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study examines whether routine treatment with semaglutide or tirzepatide, prescribed with lifestyle coaching in a real-world weight-management program, is associated with changes in biological age measured by the LinAge2 clinical aging clock over 6 months. |
JAN GRUBER; | 2026-03-02 |
| 53 | Multimodal Tongue-Pulse Information Fusion for Syndrome Diagnosis and Cohort Study in Children With Asthma PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma is one of the most prevalent chronic respiratory diseases in children, and accurate phenotyping and disease monitoring remain challenging in routine clinical practice. This observational cohort study aims to investigate the clinical value of multimodal tongue and pulse information in the syndrome diagnosis and phenotypic characterization of pediatric asthma. Children aged 5-18 years with a confirmed diagnosis of asthma will be enrolled at Shanghai Children’s Medical Center and followed in routine outpatient care. Standardized tongue images and pulse wave data will be collected using validated acquisition devices during visits when lung function testing is performed. Quantitative features extracted from tongue and pulse data will be integrated with clinical information, including asthma stage, lung function parameters, eosinophil counts, allergic sensitization status, and Asthma Control Questionnaire-5 (ACQ-5) scores. The primary objective is to evaluate the associations between tongue-pulse multimodal features and asthma clinical stages and pulmonary function. Secondary objectives include exploring their relationships with airway inflammation and asthma control status. This study seeks to establish a non-invasive, objective, and quantifiable approach to asthma phenotyping, providing evidence for integrating traditional diagnostic features with modern clinical data to support precision management of pediatric asthma. |
YONG YIN; | 2026-03-10 |
| 54 | Bronchodilator Response in COPD and Asthma: Correlation Between Spirometry, IOS Indices, and Dyspnea Relief PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A bronchodilator reversibility test is widely used in the diagnosis and management of obstructive lung diseases. Bronchodilators relieve symptoms in asthma and COPD. Traditionally, their effectiveness has been assessed using spirometric indices, particularly FEV₁. However, changes in FEV₁ often do not correlate well with patients’ subjective experience of dyspnoea relief or with changes in small airway function. Impulse oscillometry (IOS) provides an effort-independent assessment of respiratory mechanics during tidal breathing and is more sensitive to small airway dysfunction than spirometry. Despite this, the clinical utility of IOS in routine COPD and asthma assessment remains underexplored, … |
THOMAS J RINGBÆK; | 2026-01-26 |
| 55 | Remission in Adults With Mild-to-moderate Asthma in Thailand PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to determine the prevalence of remission among adults with mild-to-moderate asthma, as well as the factors associated with remission in Thailand. The main question the study aims to answer is: What is the prevalence of remission among adults with severe asthma in Thailand? Participants will complete a questionnaire on asthma symptoms and undergo pulmonary function testing and a blood test once. |
NARONGKORN SAIPHOKLANG; | 2026-01-26 |
| 56 | Impact of Comorbiditries and Disease Severity on Clinical Outcomes of Patients With Acute Exacerbations of Bronchiectesis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Acute exacerbations of bronchiectasis are associated with variable outcomes depending on patient factors. Comorbidities such as COPD, diabetes, and cardiovascular disease, as well as disease severity scores, significantly influence hospitalization rates, length of stay, need for intensive care, and mortality. Understanding these associations helps in risk stratification, guiding management, and improving prognosis in affected patients. |
ALIAA ELSAYED MAHMOUD; | 2026-01-16 |
| 57 | INHALE-1st: Technosphere Insulin (Afrezza®) In Combination With Basal Insulin For Youth With Newly-Diagnosed Type 1 Diabetes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: INHALE-1st is a Phase 2, single-arm, multi-center, clinical study evaluating the safety and efficacy of Afrezza in combination with subcutaneously-injected basal insulin (BI) for youth 10 to \<18 years old with newly diagnosed stage 3 type 1 diabetes (T1D). The study will also evaluate the effect of an Afrezza plus BI reigmen on participant and parent/legally authorized representative satisfaction. Participants will be followed for 13 weeks during the main phase followed by an optional Extension Phase for participants continuing to use Afrezza in combination with BI for up to 26 weeks. |
MANNKIND | 2026-03-23 |
| 58 | Effectivenes of Pressurized Meter Dose Inhaler (PMDI) Versus Dry Powder Inhaler (DPI) in Delivering Inhaled Corticosteroid and Long Acting Beta Agonist Among Patients With Uncontrolled Asthma in A Tertiary Care Hospital PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study compares two commonly used inhalation devices in asthma management. It focuses on evaluating how effectively PMDIs and DPIs deliver the same combination of inhaled corticosteroids and long-acting beta agonists in patients whose asthma remains poorly controlled despite treatment. The study is conducted in a tertiary care hospital setting, emphasizing real-world clinical practice and aiming to determine whether device choice influences asthma control outcomes. |
LAIBA QAMAR; | 2026-01-28 |
| 59 | Investigation of The Effects of Oxidized Antigens on The T-Cell Response and The Epigenetic Reprogramming of Neutrophils in Lung Diseases – OXIGENE – PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The OXIGENE study is a research project that aims to better understand how the immune system behaves in people with lung diseases such as asthma, COPD, pneumonia, tuberculosis, and viral lung infections. By analyzing a single blood sample, the study examines how certain immune cells react during inflammation and infection, and whether lasting changes in these cells influence how strongly the body responds to disease. Although participants do not receive direct medical benefit, the results may help improve future diagnosis and treatment of lung diseases by providing deeper insight into immune responses. |
JAN HEYCKENDORF; | 2026-02-04 |
| 60 | The Effect of Osteopathic Manipulative Treatment on Respiratory Function in Patients With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications. Osteopathic Manipulative Treatment (OMT) is a hands-on technique used to improve the chest structure and function and may help in improving breathing. Previous research showed that OMT in asthma patients, can improve the movement of the ribs and improve the peak flow which is the maximum rate at which a person can exhale air after taking a deep breath. However, … |
NANCY WASSERBAUER-KINGSTON; | 2025-12-03 |
| 61 | Cost Effective Air Filtration Intervention and Particulate Matter Monitoring in Low-Income Housing to Reduce Asthma Morbidity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project will investigate the effectiveness of HEPA air cleaners in reducing indoor air pollution and improving asthma morbidity in children living in East Harlem, New York City (NYC). The study will be conducted over a 2-year period. Columbia University and Little Sisters of the Assumption Family Health Service (LSAFHS) will conduct an intervention study to evaluate the efficacy of using a cost-effective high-capacity high efficiency particulate air (HEPA) filter air cleaner to reduce airborne particulate matter (PM) in the homes of children with asthma and to reduce their asthma morbidity. The study will take place in East Harlem, … |
MATTHEW S. PERZANOWSKI; | 2026-01-21 |
| 62 | Boosting Referrals to Asthma Specialists for Patients Seen at The Emergency Room for An Asthma Exacerbation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is testing a new way to help adults with asthma get follow up care after an emergency room (ER) visit for an asthma attack. Many people who come to the ER for asthma never see an asthma specialist afterward, even though specialists can offer treatments such as advanced inhalers or biologic medicines that may prevent future attacks. The study will compare two approaches. One group will receive a telehealth appointment with an asthma specialist that is scheduled for them before they leave the ER. The other group will receive the usual care, … |
JUAN CARLOS CARDET; | 2026-02-09 |
| 63 | Effects of Energy Conservation Exercises Versus Circuit Training on Dyspnea, Functional Capacity and Quality of Life in Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to evaluate the Effects of energy conservation exercises versus circuit training on dyspnea, functional capacity and quality of life in asthmatic patients. |
QURAT UL AIN; | 2026-04-02 |
| 64 | An Open-Label, Single-Dose Study to Assess The Safety, Pharmacodynamics, and Pharmacokinetics of CDX-622 in Adults With Mild to Moderate Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a study to determine the safety, pharmacodynamics (PD), and pharmacokinetics (PK) of CDX-622 in adults with mild to moderate asthma. |
MARIO CASTRO; | 2026-04-01 |
| 65 | Early Life Exposures Among Children With Sickle Cell Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is being conducted to determine the relationship between early childhood exposures, such as Adverse Childhood Experiences, Social Determinants of Health and nutrition/breastfeeding, among children with sickle cell disease, and behavioral interventions aimed to reshape psychological resilience and lifestyle factors towards positive health outcomes. |
BRANDI PERNELL; | 2026-02-09 |
| 66 | Exploring The Gut Microbiota and Dietary Contributors to Elevated Infant Fecal Calprotectin In Patients With Inflammatory Bowel Disease: A Pilot Study (CALINA-IBD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this prospective longitudinal cohort study is to examine how the human microbiome of pregnant women-including bacteria and fungi in the gastrointestinal tract, vaginal canal, skin, and breastmilk-may influence infant gut inflammation, measured by fecal calprotectin (FCP) levels, and to identify factors that could inform dietary interventions to improve infant health outcomes. Specifically, the study aims to determine which maternal gut microbiome characteristics and dietary patterns during pregnancy are associated with elevated FCP levels in infants, … |
GENELLE LUNKEN; | 2026-02-06 |
| 67 | Effect of Body Awareness Therapy on Physical and Psychosocial Outcomes in Adults With Asthma: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the effects of Body Awareness Therapy on physical and psychosocial outcomes in adults with asthma. Asthma is a chronic respiratory condition that can affect breathing, physical activity, and emotional well-being. In addition to medical treatment, non-pharmacological approaches that support body awareness and breathing may help individuals manage their symptoms more effectively. Participants in this study will be randomly assigned to either a Body Awareness Therapy group or a control group receiving standard care. The Body Awareness Therapy program includes guided exercises focusing on posture, breathing, movement, … |
SEDA KARACA; | 2026-02-13 |
| 68 | Optimization and Testing of ALRITE, A Clinical Decision Support Tool for Management of Respiratory Illnesses in Young Children in Primary Care Health Facilities in Uganda PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to pilot test the feasibility of a mobile health clinical decision support tool called ALRITE for the diagnosis and management of acute lower respiratory illnesses in young children in Uganda. Asthma/wheezing illness, in particular, is underdiagnosed in this setting. The main questions the study aims to answer are: * Are the intervention structure, processes, outcomes, … |
LAURA ELLINGTON; | 2026-01-27 |
| 69 | Association Analysis of Depression and Asthma: A Retrospective Cross-Sectional and Mendelian Randomization Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Main Studies Integrate retrospective studies, observational studies, and Mendelian randomization (MR) study methods to systematically analyze the strength and direction of the association between depression and asthma. Explore whether a causal relationship exists between depression and asthma, and identify potential confounding factors and effect modifiers. Secondary Studies Screen for key confounding variables that affect the association between depression and asthma (e.g., age, gender, lifestyle, comorbidities, … |
ZHENGHUA WU; | 2026-01-30 |
| 70 | A Multinational, Investigator-initiated, Parallel Group, Randomised, Double-blind, Placebo-controlled Phase 3b Superiority Trial Assessing The Effect of Dupilumab on Inducing Clinical Remission Outcomes in At-risk Type-2 Inflammatory Asthma (HOTHOT) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study tests whether an asthma medication called dupilumab can help people achieve complete asthma control (called remission) when given earlier in their disease, before asthma becomes severe. Currently, most people with asthma only receive advanced treatments like biologics after their condition has worsened significantly and caused lung damage. This study explores whether treating high-risk patients earlier could prevent asthma attacks and lung function decline, potentially achieving remission before permanent damage occurs. The study is looking for adults aged 18-79 with moderate asthma who have had at least one asthma attack requiring steroid pills in the past 2 years, … |
SANJAY RAMAKRISHNAN; | 2026-03-04 |
| 71 | A Phase 2b, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, Dose-ranging Study Investigating The Efficacy and Safety Profile of KT-621 Administered Orally to Adult Participants With Uncontrolled Moderate to Severe Eosinophilic Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This Phase 2b study is designed to evaluate the safety and efficacy of KT-621 in participants with uncontrolled moderate to severe eosinophilic asthma. The main goals of this study are to investigate how effective KT-621 is at treating uncontrolled moderate to severe eosinophilic asthma, the safety and tolerability of KT-621, and how KT-621 behaves in the body. |
KYMERA THERAPEUTICS | 2026-03-18 |
| 72 | TAPER: A Prospective, Interventional, Multicentre, Single-Arm, Phase 3b Study to Evaluate The Step-Down of Maintenance Therapy in Patients With Severe Asthma Treated With Tezepelumab PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to explore the potential for Tezepelumab-treated severe asthmatic patients to effectively and safely reduce their background maintenance medication while maintaining asthma symptom control. |
KEFANG LAI; | 2026-03-18 |
| 73 | A Randomized, Double-Blind, Placebo-Controlled Phase Ⅲ Clinical Study of Evaluating The Efficacy and Safety of CM326 in Subjects With Moderate to Severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multi-center, randomized, double-blind, placebo-controlled Phase Ⅲ clinical study to evaluate the efficacy, safety, PK characteristics, PD effects and immunogenicity of CM326 in subjects with moderate to severe asthma. The study consists of three periods, including an up to 4-week screening period, a 52-week double-blind randomized treatment period, and a 12-week safety follow-up period. |
CSPC BAIKE SHANDONG BIOPHARMACEUTICAL | 2026-01-28 |
| 74 | Evaluation of The Effect of Thymoquinone Hydrogel With Bone Graft in Comparison to Bone Graft Only Around Immediate Implant (Randomized Controlled Clinical Trials) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: use of Thymoquinone hydrogel with bone graft in comparison to bone graft only around immediate implant-this hydrogel fill the jumping zone in comparison to using hydrogel bone graft only to increase primary stability and enhance osseointegration |
SHAIMAA HAMDY; | 2026-02-05 |
| 75 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy and Safety of GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to assess the potential for GB-0895 treatment to improve the health of adolescents and adults with severe asthma that is uncontrolled by inhaled corticosteroids (ICS) and conventional asthma controllers. The study details include: Study treatment: randomized to receive either GB-0895 or placebo administered every 6 months over 52 weeks. Visit frequency: every 1-2 months after the first month. |
GENERATE BIOMEDICINES | 2026-04-02 |
| 76 | Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is being conducted to evaluate the ability of the Respiratory Monitoring System (RMS) to detect and predict opioid induced respiratory depression (OIRD) in post-operative surgical patients managed with opioid medications. The ability of the RMS to detect OIRD will be compared to the detection of OIRD using a commercial capnometer, pulse oximeter, airflow monitor, and breathing volume monitor . We hypothesize the RMS will detect the onset and progression of a true OIRD event with high sensitivity, specificity, positive predictive value, … |
MARC C TORJMAN; | 2026-02-09 |
| 77 | Safety and Efficacy of Midazolam Alone Versus Midazolam With Ketorolac in Patients Undergoing Flexible Bronchoscopy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Flexible bronchoscopy has evolved into a vital diagnostic and therapeutic intervention in respiratory medicine due to its frequent and diverse applications. It enables direct visualization of the tracheobronchial tree and facilitates procedures such as bronchoalveolar lavage, tissue sampling, and foreign body extraction. However, despite its clinical importance, the procedure is associated with patient discomfort due to airway manipulation, hypoxia, coughing and procedural pain. These discomforts can lead to poor patient cooperation, excessive movement, procedure related anxiety and even premature termination of the procedure, … |
SYED HAIDER ALI; | 2026-01-20 |
| 78 | Measuring Small-Airways Disease Improvement After Step-up to Extrafine TRIple or High-dose ICS/LABA in Patients Uncontrolled on Medium Dose ICS/LABA EXploring T2 Inflammation: The MATRIX Real-life Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to investigate the change in small airway function through the R5-R19 index in oscillometry at 12 weeks in adults with asthma. The main question it aims to answer is: How can small airways dysfunction as evaluated by the oscillometry measure R5-19 be improved at 12 weeks, … |
KONSTANTINOS KOSTIKAS; | 2026-02-03 |
| 79 | Effect of Modified Shenling Baizhu Powder on Allergic Asthma With Spleen Deficiency and Dampness Accumulation Syndrome: A Multicenter, Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Allergic asthma is a common allergic disease characterized by a protracted disease course and recurrent episodes, which severely impairs patients’ physical and mental health. There is a paucity of high-quality clinical evidence in the treatment of allergic asthma with traditional Chinese medicine (TCM). This study will enroll patients who are persistent allergic asthma with spleen deficiency and dampness accumulation syndrome. A multicenter, randomized, double-blind, placebo-controlled trial design is adopted. The experimental group will receive Modified Shenling Baizhu Powder in addition to Budesonide and Formoterol Fumarate Powder for Inhalation, … |
HENAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE | 2026-01-20 |
| 80 | A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 12-Week Study to Evaluate The Efficacy, Safety, and Pharmacokinetics of ENV-294 in Adult Participants With Moderate-to-Severe Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and potential efficacy of ENV-294 in adults with moderate to severe asthma who are receiving background treatment with inhaled corticosteroids (ICS) and long-acting beta₂-agonists (LABA). Participants will take oral ENV-294 or placebo once daily for 12 weeks. The study includes a screening period of up to 28 days before randomization to confirm eligibility. Study visits and assessments will be conducted to monitor safety, measure drug levels in the blood, and evaluate effects on asthma control and lung function. |
ENVEDA THERAPEUTICS | 2026-03-31 |
| 81 | CHEST: A Collaboration With Community HEalth Centers to Implement SmarT for Asthma PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose: This study aims to improve asthma care by helping clinicians at community health centers prescribe a guideline-recommended treatment called SMART (Single Maintenance and Reliever Therapy). The investigators will provide training and resources to clinicians, give feedback on prescribing patterns, and offer educational tools for patients and providers. The investigators will roll out these resources in stages across clinics. The study will measure how well the program helps clinicians prescribe SMART therapy and whether it reduces asthma exacerbations in patients. |
JAMES KRINGS; | 2026-01-16 |
| 82 | A Novel MHealth Intervention to Improve Outcomes of Children With Medical Complexity PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Children with medical complexity (CMC) are the most vulnerable of children with chronic diseases, who have complex, multisystem chronic diseases affecting ≥3 organ systems, severe functional limitations and technology dependencies. CMC have high health care needs, and account for 40% of hospitalized children and 35% of all pediatric health care costs. Due to high medical fragility, CMC have frequent acute deteriorations superimposed on their chronic conditions, leading to recurrent emergency department (ED)/hospital admissions and affecting quality of life (QOL). To reduce ED/hospital admissions for CMC, remote monitoring is suggested, … |
FLORY NKOY; | 2026-01-12 |
| 83 | A Phase 2-Phase 3, Double-blinded, Randomized, Dose-repeating, Cross-over Study to Assess The Safety and Efficacy of Allogeneic ULSC on Disease Severity and Steroid Tapering in Participants With Dermatomyositis/ Polymyositis (DM/PM) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn about how an umbilical cord lining-derived stem cell (ULSC) product performs when treating Dermatomyositis/Polymyositis (DM/PM), also known as idiopathic inflammatory myopathy (IIM) in adults. It will assess safety and efficacy in relieving symptoms of DM/PM with ULSC administered in three intravenous (IV) doses of 150 million cells per dose. The main questions that this study plans to answer are: * Is ULSC as safe as placebo (a look-alike saline without cells) in repeated IV infusion? * Does ULSC improve symptoms of DM/PM after three doses? Researchers will compare ULSC to placebo and evaluate changes from baseline (before first dose) to after each dose and after all three doses are completed per treatment study period. * For participants undergoing steroid (e.g., prednisone) therapy for DM/PM, does ULSC allow their steroid dose to be reduced? Does ULSC reduce need for rescue therapy? Participants will have been diagnosed with either DM or PM: * Diagnosed according to the EULAR/ACR 2017 Classification Criteria for idiopathic inflammatory myositis (IIM), which includes DM and PM. * Positive for myositis-associated antibody or undergone evaluation to exclude mimics. Participants in this study will: * Participate for total of 25 months with 15 in-person clinic visits and 8 virtual visits on phone or video call. * Receive both ULSC and placebo for a total of 6 IV infusions (260 mL) 3 months apart. * Receive 3 doses of ULSC and 3 doses placebo in either of two sequences, as assigned: ULSC first and placebo second, or placebo first and ULSC second. * If undergoing steroid therapy, will have steroid dose taper prescribing lower doses starting two weeks after the second infusion. * Return for follow-up visits after each dose and up to 12 months after final dose. * Have follow-ups including self-reported questionnaires, physical exam, muscle strength and endurance tests, blood tests, pulmonary function tests, and other assessments. |
MICHAEL BUBB; | 2026-03-30 |
| 84 | Reflections of Inspiratory Muscle Training on Patient Experiences in Asthma Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to investigate asthma patients’ experiences with an 8 week IMT and the perceived effects of this intervention on physical activity, coping strategies, and asthma self-management. A qualitative methodological design will be applied to understand the experiences of patients participating in the IMT program, how the program affected their daily activities, how they coped with symptoms and difficulties, and how they managed their condition. |
CAHIDENUR KOÇAK; | 2026-01-09 |
| 85 | Analysis of The Expression Profiles of Inflammation-regulating MicroRNAs in Serum and Tear Samples From Subjects With Allergic Conjunctivitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Allergic conjunctivitis (AC) causes inflammation of the conjunctiva in response to environmental allergens, affecting a significant percentage of the world population and reducing quality of life. The pathophysiology is poorly understood, lacking effective treatments. MicroRNAs have potential for diagnosing and characterizing inflammatory diseases. This study aims to compare the expression profiles of inflammation-regulating microRNAs (miR-19, miR-23, miR-125b, miR-146a, and miR-155) in serum and tear samples from subjects with AC and healthy subjects to identify biomarkers and therapeutic targets. |
MARÍA C. JIMÉNEZ MARTÍNEZ; | 2026-02-04 |
| 86 | Post-partum Retention of Vernix Caseosa for Primary Prevention of Atopic Dermatitis, Guarding Skin Integrity and Fostering A Healthy Microbiome PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Atopic dermatitis (AD), also known as eczema, is a common chronic inflammatory skin disease that usually begins in infancy and causes significant itching, discomfort, and sleep disturbance. It affects up to one in five children worldwide and represents a growing public-health problem. Research has shown that genetic and environmental factors contribute to its development, especially those related to skin-barrier integrity and the skin microbiome during early life. Preventing AD before it starts-known as primary prevention-has become an important goal. Vernix caseosa is a naturally occurring, white, … |
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE | 2026-01-12 |
| 87 | Promoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination in Clinics and Schools (PRAGMATIC-S) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The overall goal of this research study is to evaluate a multi-level program called PRAGMATIC-S to improve the delivery of guideline-based asthma care through a unique partnership between clinical practices and schools. PRAGMATIC-S represents a novel approach that addresses multiple barriers to adherence by bridging primary care and schools, ensuring delivery of guideline-based asthma care to urban children across these settings thereby improving adherence to therapy and clinical outcomes. |
MARINA REZNIK; | 2025-11-03 |
| 88 | Advancing Diagnosis and Treatment of Pediatric Asthma By Deep Immunophenotyping and Evaluation of Two Spacer Devices for Inhaled Corticosteroid Administration PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma is one of the most common chronic diseases in children, and treatment success often depends on proper inhaler use and consistent medication adherence. Exposure to allergens and pollutants can also impact treatment response and asthma control. Moreover, there is a growing need for non-invasive biomarkers to support better diagnosis and personalized care. The goal of this clinical trial is to investigate if a new digital inhaler can improve inhalation technique and treatment adherence in children aged 5 to 16 years old, … |
CHRISTIANE HILGER; | 2026-03-30 |
| 89 | A Multi-center, Randomized, Double-blind, Placebo-controlled Trial of Topical Ketotifen Fumarate 0.25% Cream for Females With Secondary Vestibulodynia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 2, multi-center, randomized, double-blind, placebo-controlled trial evaluating the safety and efficacy of topical ketotifen fumarate 0.25% cream in adult women with secondary provoked vestibulodynia (PVD). Secondary PVD is a chronic vulvar pain condition characterized by burning or sharp pain with vaginal penetration (e.g., intercourse, tampon use) and touch of the vulvar vestibule, often following recurrent infections or topical irritant exposures. Preclinical studies suggest that ketotifen, a mast-cell stabilizer and histamine H1 antagonist, may reduce neuroinflammation and abnormal nerve growth in the vulvar vestibule, offering a mechanism-based, … |
ANDREW T. GOLDSTEIN; | 2026-03-18 |
| 90 | Effectiveness of Early Immunization With Nirsevimab on Preschool Wheezing in France PF:10 Related Papers Related Patents Related Grants Related Experts Highlight: Early respiratory syncytial virus (RSV) bronchiolitis is a well-known contributing factor of mid- and long-term respiratory sequelae in children such as recurrent lower tract respiratory infections (LRTIs), preschool wheezing (PW) or decreased lung function at older ages. Nirsevimab, a monoclonal antibody against RSV with enhanced neutralizing activity and a prolonged half-life, has shown great potential in reducing short term outcomes such as hospitalization for RSV associated bronchiolitis (estimated adjusted effectiveness against hospitalization to 83.0% (95%CI: 73.4 to 89.2). Other countries that have been using nirsevimab almost exhaustively have reported similar results such as in Galicia. However, … |
HOSPICES CIVILS DE LYON | 2026-01-08 |
| 91 | A Prospective Cohort Study on Comprehensive Care of Sleep Disordered Breathing (Care-SDB Study) PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The Comprehensive Care of Sleep Disordered Breathing study (Care-SDB) is a prospective, multi-center, registry-based cohort study designed to investigate the integrated management of sleep-disordered breathing (SDB). The investigators aim to establish a nationwide SDB cohort and biobank to identify prognostic biomarkers, explore pathogenic mechanisms, and evaluate optimal treatment models. A total of 11,100 adult patients with recent sleep monitoring will be enrolled and followed longitudinally for up to 5 years. Data collection, including clinical outcomes and major adverse events, … |
SHAO-PING NIE; | 2026-01-21 |
| 92 | Surgery for Unstable Chest Wall Injuries – How Many Fractures Should Be Fixed? PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this prospective, randomized study is to learn about the effects of two different surgical techniques for treating unstable chest wall injuries in adults. The main questions it aims to answer are: Does fixing two fractures per rib lead to better healing than fixing one fracture per rib in patients with unstable chest injuries? Does the choice of surgical method affect lung function, pain, other symptoms, risk of pneumonia, or the risk of complications? Participants will: * Undergo surgery using either the standard method (fixing one fracture per rib) or an alternative method (fixing two fractures per rib), … |
ERIK ÖBERG WESTIN; | 2026-01-14 |
| 93 | Point of Care Ultrasound (POCUS) for Diagnosis and Treatment of Fractures in The Costal Cartilage PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn if combining ultrasound and CT scans can better diagnose cartilage fractures in the ribs, and to understand how finding these injuries affects treatment decisions for patients with injuries to the Chest wall. The main questions it aims to answer are: * Does using both ultrasound and CT scans find more costal cartilage fractures than CT scans alone? * Does discovering costal cartilage fractures change how patients are treated, such as whether more patients receive surgery or if different fractures are repaired? * How do costal cartilage fractures heal, … |
ERIK ÖBERG WESTIN; | 2026-01-14 |
| 94 | Wenjuanxing-Based Multidimensional Etiologic Screening and Clinical Validation of Chronic Cough in Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic cough is a common and burdensome condition in children, with complex and overlapping etiologies that often lead to delayed diagnosis, misdiagnosis, and inappropriate treatment. This prospective, controlled, observational study aims to develop and clinically validate a Wenjuanxing-based, parent-reported, multidimensional etiologic screening questionnaire for pediatric chronic cough. Children aged 3-18 years presenting with cough lasting ≥2 weeks will be enrolled in a tertiary pediatric respiratory clinic and allocated to either a routine-care group or a questionnaire-assisted group. All caregivers will complete the standardized electronic questionnaire, which generates an automated preliminary etiologic suggestion based on symptom patterns, triggers, … |
YONG YIN; | 2025-12-29 |
| 95 | Assessment of Asthma Management in Children Over 6 Years of Age and Their Caregivers. Implications for The Implementation of The SMART Strategy in Pediatrics PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to see if a short educational session and demonstration by a nurse can help asthmatic children (6-17 years-old), under hospital control, to manage their asthma better, to use their inhaler correctly, and to know when it should be used. The main question it aims to answer is how much improvement is reached on asthma self-management. The comparison group is the same group. Researchers will compare results before and after educational intervention. |
VICTÒRIA MORÓN FAURA; | 2026-01-23 |
| 96 | A Multinational Randomized Double-Blind Placebo-Controlled Phase 2 Study to Evaluate The Effect of Linvemastat (FP-020) in Patients With Partially Controlled Asthma on Inhaled Corticosteroids and Long-Acting Beta-Agonists (syMMPonia Study) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study explores a potential new treatment for adults with moderate-to-severe asthma using a drug called linvemastat, which targets an enzyme linked to lung inflammation. Despite using standard asthma medications, many patients still struggle with symptoms, so researchers are testing whether linvemastat can improve lung function and reduce flare-ups. In a carefully controlled trial, participants receive either one of two doses of the drug or a placebo, while continuing their usual treatments. Over 16 weeks, scientists monitor breathing capacity, symptom control, and safety to determine if linvemastat could offer a meaningful new option for asthma management. |
FORESEE PHARMACEUTICALS | 2025-10-20 |
| 97 | Remission in Adults With Severe Asthma in Thailand PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to determine the prevalence of remission among adults with severe asthma, as well as the factors associated with remission in Thailand. The main question the study aims to answer is: What is the prevalence of remission among adults with severe asthma in Thailand? Participants will complete questionnaires on asthma symptoms and undergo pulmonary function testing and a blood test once. |
NARONGKORN SAIPHOKLANG; | 2026-01-13 |
| 98 | Efficacy of Oral Nigella Sativa As Adjuvant Therapy in Children With Moderate Persistent Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Complementary and adjunctive therapies are increasingly being explored to enhance asthma control and reduce airway inflammation. Nigella sativa (black seed) is a medicinal plant used traditionally in multiple regions and has demonstrated anti-inflammatory, immunomodulatory, and bronchodilator effects. Its potential as an adjuvant therapy in asthma has attracted attention in both preclinical and clinical research |
REHAB ZAKI ELMEAZAWY; | 2026-01-02 |
| 99 | A Study on Improving Sleep Quality in COPD Patients Through Inhalation Management Education By Nurses Using Video Conferencing Tools PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate whether inhalation management education provided by nurses improves sleep quality in patients with COPD. Inhalation management education includes training in inhalation techniques and guidance on how to use medications when symptoms occur. The main research question is: ・Does inhalation management education improve sleep quality in patients with COPD? Researchers will determine whether inhalation management education improves sleep quality compared to no education. Participants will: * Participate in two interviews with researchers using video conferencing tools. * Keep a diary recording their symptoms, sleep duration, and the frequency of rescue inhaler use. |
ASUKA HASHINO; | 2025-12-31 |
| 100 | The Association Between Problematic Media Use and Postoperative Pain Severity in Pediatric Patients Undergoing Tonsillectomy: An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study aims to investigate whether problematic media use is associated with postoperative pain severity in children aged 4-11 years undergoing tonsillectomy. A total of 94 parents who consent to participate and have children within the target age range will be included. Data will be collected using a structured questionnaire covering sociodemographic characteristics, family and child media habits, parental attitudes toward screen use, and the Problematic Media Use Scale (PMUS). Postoperative pain will be assessed using the FLACC scale at multiple time points within the first 24 hours after surgery. |
ALI GENC; | 2025-12-22 |
| 101 | A Prospective, Multicenter, Observational Cohort Study on The Efficacy and Safety of Biological Agents in Patients With Allergic Bronchopulmonary Aspergillosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy and safety of biological agents in patients with allergic bronchopulmonary aspergillosis. |
QIAN QI; | 2026-01-23 |
| 102 | Early Identification of Children With Asthma in Electronic Medical Records in Primary Care PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: GPs are one of the key players in the early diagnosis of chronic diseases, such as asthma in pre-school children, by detecting symptoms of illness as early as possible. Patient health data is collected on an ongoing basis in GPs’ electronic medical records, but remains little exploited despite its potential. Helping GPs to identify asthma in pre-school children, based on the information in their electronic medical records, … |
UNIVERSITY HOSPITAL ROUEN | 2025-10-02 |
| 103 | Impact of Comorbidities, Some Biomarkers, Micro RNA in Childhood Asthma Phenotypes, Severity and Response to Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: * Assess response to treatment in children with bronchial asthma attending Assiut university children hospital. * Role of comorbidities in controlling symptoms of bronchial asthma. * Evaluate the role of the soluable interleukin 5 receptor, I C-telopeptide of type I collagen (ICTP), miR-223-3p and miR-191-5p in bronchial asthma. |
AGHAPY GAMAL ZAHY SHAFIK; | 2025-11-17 |
| 104 | A Study to Evaluate The Accuracy of Primary Care Diagnosis Using Oscillometry and Fractional Exhaled Nitric Oxide for Asthma and COPD Versus Specialist Diagnosis in Patients With Suspected Asthma or COPD PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Current diagnostic methods for asthma and chronic obstructive pulmonary disease mostly depend on pulmonary function tests, especially spirometry. While spirometry is a foundational tool, its diagnostic accuracy is often limited by the patient’s ability to perform forceful breathing maneuvers, as well as technical and reproducibility challenges, and the need for proper equipment and training. These constraints can compromise effective diagnosis of asthma and COPD in primary care settings. Prompt and accurate diagnosis by primary care physicians is essential for better patient outcomes. Although variable airflow limitation often measured as a change in FEV1 after bronchodilator is a hallmark of asthma, … |
ASTRAZENECA | 2026-03-17 |
| 105 | A Multi-center, Randomised, Double Blind, Active Controlled Phase III Trial to Compare The Efficacy and Safety of QL2302 With Tezspire® in Adults With Uncontrolled Severe Asthma PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to compare the efficacy and safety of QL2302 and Tezspire® in patients with uncontrolled severe asthma. The main questions it aims to answer are: * if the efficacy of QL2302 and Tezspire® are similar * if the safety of QL2302 and Tezspire® are similar Participants will be randomised to QL2302 or Tezspire® group and asked to receive one injection of QL2302 or Tezspire® subcutaneously every four weeks till Week 48, which means participants will receive a total of 13 injections. And be observed for another 12 weeks after the end of treatment. |
QILU PHARMACEUTICAL | 2025-12-24 |
| 106 | Open-label Single-arm, Non-interventional, Multi-centre Study for Evaluation of Clinical and Patient Reported Outcomes in Adult Patients With CRSwNP on Tezepelumab PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: ARES is a multi-centre, retrospective-prospective, non-comparative and non-interventional (observational) cohort study involving primary and secondary data collection within real-world settings of participants who have initiated tezepelumab (no more than 4 weeks before inclusion) for treatment of CRSwNP (with or without comorbid asthma). |
ASTRAZENECA | 2026-04-03 |
| 107 | The Impact of Medical TV Drama in Improving Literacy on Asthma: An Online Open-Label Two-arm Randomized Control Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma is an important chronic noncommunicable disease that affects children and adults following a complex immune-mediated mechanism involving airway inflammation, bronchial hyperresponsiveness, and transient and intermittent airway obstruction. A current global empirical study, published in 2025, estimated that asthma affects about 260 million people, and it is responsible for about 455,000 deaths globally. Despite the morbidity and mortality-laden nature of asthma, the awareness and knowledge of this important condition remains low among several populations. Notably, no known multi-country intervention study has ever investigated the effectiveness, acceptability, and usability of medical TV programs in educating young persons on asthma. Therefore, … |
EMEKA OKEKE; | 2025-12-04 |
| 108 | Optimizing A Sensor-Enabled MHealth Intervention for Adolescents With Suboptimal Asthma Control PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma affects nearly 1 in 10 teenagers in the United States and can seriously impact their health and daily life. Teens are expected to manage their asthma by taking medications correctly and paying attention to symptoms, but this can be hard. Adolescents are still developing the skills needed to manage their thoughts, feelings, and behaviors, and they often receive less help from parents during this time. Because each teen struggles in different ways and at different times, … |
CHRISTOPHER C CUSHING; | 2025-12-24 |
| 109 | ItAlian, Multicenter, Observational, Prospective STudy to Evaluate The AcHievement of Clinical REmission and ImmuNomodulation in Severe Eosinophilic Asthma Patients Treated With Benralizumab – The ATHENA Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is an observational, multicenter, prospective study on patients with severe eosinophilic asthma treated with benralizumab aimed at evaluating the achievement of partial and complete clinical remission. |
ASTRAZENECA | 2026-03-10 |
| 110 | A Diagnostic Accuracy Study: N-Tidal Assessment for Respiratory Diagnosis Compared to Using Standard Testing PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The diagnosis of either asthma or chronic obstructive pulmonary disease (COPD) is currently based on a combination of symptoms, different lung tests and sometimes a ‘trial by treatment’. Both COPD and Asthma tests currently include forced breathing using a test known as spirometry which can be difficult and uncomfortable for people to perform and needs expert interpretation. Asthma can require multiple tests in sequence which can make the process of diagnosis long and inconvenient for patients. In the UK, there have been challenges providing enough testing for COPD and asthma, … |
LIVERPOOL HEART AND CHEST HOSPITAL NHS FOUNDATION TRUST | 2025-11-28 |
| 111 | A Phase II Multinational, Multicentre, Double-blind, Randomised, Active-controlled, 3-way Cross-over Study to Evaluate The Therapeutic Equivalence of CHF5993 PMDI 100/6/12.5 Μg HFA-152a Versus CHF5993 PMDI 100/6/12.5 Μg HFA-134a in Subjects With Mild to Moderate Asthma PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This study will compare an asthma inhaler that uses a new climate friendly alternative propellant to an asthma inhaler with an existing propellant. We want to make sure both versions of the inhaler work the same way for people with mild to moderate asthma. |
PIOTR KUNA; | 2026-01-12 |
| 112 | Effects of The 4-7-8 Breathing Technique, One of The Deep Breathing Techniques, on Postoperative Pain Scores, Anxiety, and Sleep Quality in Patients Undergoing Laparoscopic Cholecystectomy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the effects of teaching the 4-7-8 breathing technique, one of the deep breathing techniques, to patients undergoing laparoscopic cholecystectomy surgery and applying it during the preoperative and postoperative periods on postoperative pain levels, anxiety levels, and sleep quality. Secondary objectives are to evaluate patients’ postoperative peripheral oxygen saturation and length of hospital stay. Patients will be randomized into two groups using a closed opaque envelope technique, … |
SAMI UYAR; | 2025-12-26 |
| 113 | Automated Inhaler Monitoring for Asthma Medication Usage PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the aflo™ digital platform’s ability to improve inhaler use technique and asthma control for children, adolescents, and adults with uncontrolled asthma. The main questions the trial aims to answer are: 1. Does the platform improve medication adherence and inhaler technique, as measured by the Inhaler Proficiency Score (IPS)? 2. Does the aflo™ platform improve asthma control, as measured by changes in the Asthma Control Test (ACT) and lung function tests (FEV1, … |
WANDA PHIPATANAKUL; | 2026-02-10 |
| 114 | Canadian Consortium for Understanding The Role of Airway Mucus Occlusions in Asthma, COPD and Chronic Cough PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic lung diseases affect one in five Canadians, causing symptoms such as cough, breathlessness, and wheeze. Despite advancements in medical care, these conditions not only impact individuals and their close circles but also present substantial clinical and economic challenges at a national level. This grant is dedicated to addressing three prevalent lung diseases: asthma, chronic obstructive pulmonary disease (COPD), and chronic cough. An alliance of clinicians, scientists, knowledge users, and patient partners from across Canada have come together to establish the Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD, and Chronic Cough – … |
MCMASTER UNIVERSITY | 2026-01-07 |
| 115 | Outcome of Active Aspiration Versus Simple Compression to Remove Residual Gas From Abdominal Cavity in Reducing Pain After Laparoscopic Cholecystectomy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to compare outcome of active aspiration versus simple compression to remove residual gas from abdominal cavity in reducing pain after laparoscopic cholecystectomy. |
KING EDWARD MEDICAL UNIVERSITY | 2025-12-23 |
| 116 | Evaluate The Long-term Nutritional Impact of Necrotizing Enterocolitis at 5 Years, in Premature Newborns in The NICU of NANCY Over 10 Years PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: With premature newborn increase survival, the risk of serious neonatal morbidity, such as necrotizing enterocolitis (NEC), also increased. NEC affects between 2 to 7% of premature infants including 5 to 22% of newborns weighing less than 1000 g. NEC is an acquired disease, caused by inflammation of the intestinal lining. It is the most common life-threatening gastrointestinal emergency of prematurity, associated with a significant morbidity and mortality. The etiologies and pathophysiology of this disease are multifactorial and complex, … |
LAMIREAU NATHALIE; | 2026-03-24 |
| 117 | Characterization, Perceived Stress Scores, Nut Consumption and Bowel Patterns of A Healthy Adult Population in Northern California: A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to gather health and nutrition data from the population of Davis, CA and surrounding areas. This data will be used to help us test and improve our study procedures for a larger planned study on peanut consumption and effects on cardiovascular disease (CVD) risk. |
RYAN SNODGRASS; | 2026-01-29 |
| 118 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy and Safety of GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to assess the potential for GB-0895 treatment to improve the health of adolescents and adults with severe asthma that is uncontrolled by inhaled corticosteroids (ICS) and conventional asthma controllers. The study details include: Study treatment: randomized to receive either GB-0895 or placebo administered every 6 months over 52 weeks. Visit frequency: every 1-2 months after the first month. |
GENERATE BIOMEDICINES | 2026-04-02 |
| 119 | Randomised Controlled Trial Of Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate usual care versus biomarker-directed care (using blood eosinophil counts) for the management of asthma patients in primary care setting. The study hypothesizes that BEC is a valuable biomarker that can guide asthma treatment, and result in reduction in asthma exacerbations, better symptom control and improvement in quality of life compared to usual arm in mild to moderate asthma patients in the primary care setting. Researchers would compare using blood eosinophil count guided to usual care to see if biomarker-directed asthma treatment and management |
WERN EE TANG; | 2026-03-20 |
| 120 | Effects of Combined Posture Correction Exercise and Resistive Respiratory Muscle Training on Dyspnea, Chest Expansion, Craniovertebral Angle and Pulmonary Function Test, in COPD Patients With Forward Head Posture PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation, often exacerbated by postural abnormalities such as forward head posture (FHP). FHP can lead to significant alterations in breathing patterns, reducing the efficiency of respiratory muscles and impairing lung function. Patients with COPD and FHP frequently exhibit muscular imbalances, where overactive accessory muscles compensate for weakened primary respiratory muscles Resistive Inspiratory Muscle Training strengthens inhalation muscles using resistance devices to enhance respiratory function in COPD patients. Resistive Expiratory Muscle Training focuses on strengthening exhalation muscles through resistance during exhalation, … |
WAJEEHA ZIA; | 2026-01-05 |
| 121 | Impact of Acute Exercise and Habitual Physical Activity on Human Milk Composition and Childhood Obesity Risk PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to learn how exercise and physical activity during pregnancy and after pregnancy may affect the composition of breastmilk. Certain changes in breast milk after exercise may have an impact on how infants use energy. Understanding this process may improve public health recommendations for exercise during and after pregnancy. This study can help investigators learn more about how maternal exercise patterns may affect body growth and obesity risk in infants who are breastfed. This research may help identify how different factors can influence healthy weight and early development in infants. |
DAVID FIELDS; | 2026-03-12 |
| 122 | A Phase II, Double-blind, Randomized, Placebo-controlled, Parallel-group, Multiple-dose Study to Investigate The Safety and Efficacy of 3-month AD17002 Treatment in Adults With Inadequately Controlled Moderate to Severe Eosinophilic Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. Eosinophilic asthma, a type 2 immune disorder, often involves the excessive production of type 2 cytokines. 2. Excessive Type 2 cytokines lead to chronic inflammation, airway hyperresponsiveness, and airflow obstruction. 3. AD17002 is an intranasal self-applicable immunomodulator. 4. AD17002 is safe and tolerable in all studied clinical trials. 5. AD17002 elevates local type-1 interferon levels and promotes epithelial healing. 6. Type-1 interferons have been demonstrated to restore immune balance and reduce eosinophilic infiltration. AD17002, an innate immune modulator, is likely to be effective as an add-on therapy to control poorly managed moderate to severe eosinophilic asthma. |
ADVAGENE BIOPHARMA | 2025-11-26 |
| 123 | Retrospective Study Investigating The Clinical Characteristic of Patients with Acute Presentation for Asthma to The A+E Department in A Busy Acute Hospital in England UK in Era of Biological Therapy for Asthma Between Jan 2019 & Jan 2024 PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Study team will obtain a list of all patients who have been seen in A+E over the past 6 years with a discharge diagnosis of asthma. Their history will be reviewed from their A+E notes. Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participant’s GP records. Team will use participant’s postcode to word out socio economic status quintile using office of national statistics tool. The following information will be taken from hospital documentation and from GP records. |
SADIYAH HAND; | 2025-02-27 |
| 124 | Prospective Clinical Study on The Clinical Efficacy and Prognostic Outcome of ICS/LABA Combined With Liqin Zhike Formula in The Treatment of Cough Variant Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To investigate the impact of the combination of ICS/LABA and Liqin Zhike Formula on the clinical efficacy and prognostic outcomes of cough variant asthma. |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-12-09 |
| 125 | Relationship Between Dysfunctional Breathing, Respiratory Patterns, and Performance Anxiety in Music Students PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to determine the prevalence and patterns of dysfunctional breathing (DB) among music students and to investigate its relationship with music performance anxiety (MPA). Dysfunctional breathing, also known as a breathing pattern disorder, refers to maladaptive respiratory patterns not explained by medical conditions such as asthma and is associated with symptoms like hyperventilation, poor breathing control, and abnormal respiratory mechanics. Given that MPA is common among musicians and often accompanied by symptoms such as palpitations, tremor, and shortness of breath, this study explores whether DB contributes to or is influenced by performance-related anxiety in this population. |
ERHAN KIZMAZ; | 2025-11-14 |
| 126 | Bridging The Gap Between Prescription and Practice: Impact of Nurse-Led Inhaler Education on Patient Technique, Knowledge, Adherence, and Beliefs – A Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma and chronic obstructive pulmonary disease (COPD) are among the most prevalent chronic respiratory conditions worldwide, affecting hundreds of millions of individuals and contributing substantially to morbidity, mortality, and healthcare burden. Although clinicians routinely advise patients verbally on inhaler use, the lack of structured, hands-on education results in significant variation in technique and consistently poor retention of skills over time. |
MOHAMED ABD ELMONIEM MOHAMED; | 2026-03-02 |
| 127 | Clinical Study on The Safety, Tolerance and Preliminary Efficacy of Human Mesenchymal Stem Cell Therapy for Parkinson’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study, through different administration methods, adopted a randomized, double-blind, placebo-controlled trial design to evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells (hUC-MSCs) in patients with Parkinson’s disease, explore their initial effectiveness and the relationship between biological active factors and therapeutic efficacy. The Clinical Study on the Treatment of Parkinson’s Disease with Human Umbilical Cord Mesenchymal Stem Cells of this study is expected to provide clinical trial evidence for the development of safe and effective clinical cell therapies for patients with Parkinson’s disease. |
LIAONING MEDICAL DIAGNOSIS AND TREATMENT TECHNOLOGY RESEARCH AND DEVELOPMENT | 2025-11-18 |
| 128 | A Randomized, Double-blind, Placebo-controlled Phase 2a Study of ARO-RAGE Inhalation Solution to Assess Efficacy on Small Airway Dysfunction in Allergen-induced Mild Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the impact of inhaled ARO-RAGE on the late asthmatic response (LAR) following an inhaled allergen challenge in participants with mild atopic asthma. |
ARROWHEAD PHARMACEUTICALS | 2025-11-21 |
| 129 | Positioning of Children With Acute Respiratory Insufficiency PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Acute respiratory insufficiency is one of the most common causes of hospitalization and death among young children. It often affects small children who, due to infections with RSV (respiratory syncytial virus), other cold viruses, or bacteria, experience difficulty breathing, rapid breathing, increased heart rate, low oxygen levels in the blood, and reduced appetite. If left untreated, a child can become exhausted, lose consciousness, and ultimately die from the condition. Children with severe acute respiratory insufficiency occupy most of the acute care beds in the pediatric wards of hospitals during the winter months. Some children are treated simply with saline inhalations, … |
JOSEFINE GRADMAN; | 2025-12-11 |
| 130 | A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical Practice PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study will explore how Wegovy® (Semaglutide) is used in everyday situations, how it might affect things like weight, body mass index (BMI) and waist circumference, and what kind of impact it could have on overall quality of life. The overall purpose of this study is to understand how Wegovy impacts weight when used as part of regular medical care. Participants will be treated with Wegovy as prescribed to the participant by their doctor, in accordance with normal clinical practice. The study will last for about two years. |
NOVO NORDISK | 2026-03-05 |
| 131 | Remote Monitoring of Asthma in Children and Young People – Reducing Risk of Asthma Attack Using A Connected Patient Approach PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to determine whether healthcare data and remotely collected patient data can accurately predict asthma attacks in children and young people aged 5-17 years. The main outcome is: when using this new system, is there a reduction in asthma attacks compared with a historic average. The whole population of children and young people with asthma will have routine healthcare data monitored, with a subset of people with high risk asthma asked to participate in a more detail study involving remotely monitored data. |
UNIVERSITY OF EDINBURGH | 2026-01-22 |
| 132 | Atopic Dermatitis Disease Registry of Adult and Adolescent Patients Initiating or Switching Systemic Treatments PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The objectives of this prospective non-interventional study are to characterize the existing unmet needs across the spectrum of atopic dermatitis (AD), enhance the understanding of the patient journey, and evaluate the safety and clinical outcomes of systemic AD treatments in a real-world setting. Additionally, patient-specific factors (such as age, skin color, AD flare triggers, previous treatment responses, comorbid conditions, and the extent and site of lesions) will be assessed to better characterize the impact on the treatment journey across a broad age range and diverse geographic regions. The study will be conducted across 10 countries in 4 different geographical regions, … |
VLADA GROYSMAN; | 2026-04-01 |
| 133 | Characterization of The Gut Microbiota Metagenomic Signature According to Physical Fitness and Its Implications for Intestinal Health PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The gut microbiota comprises all microorganisms inhabiting the digestive tract, evolving throughout life under the influence of various intrinsic and extrinsic factors. Under healthy conditions, the microbiota remains stable, resilient, and maintains a symbiotic relationship with its host. Conversely, dysbiosis refers to an alteration in microbial composition and function, which has been linked to diseases such as inflammatory bowel disease (IBD). IBD, including Crohn’s disease and ulcerative colitis, is associated with a disrupted microbiota compared to healthy individuals, … |
FRÉDÉRIC DERBRÉ; | 2025-12-24 |
| 134 | A Phase Ll Randomized Controlled Trial of Soluble Fiber for Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Randomized controlled trial of soluble fiber (Fruitafit Inulin). Participants will complete an ASA 24 dietary recall questionnaire to access their fiber intake. If eligible for the study, participants will be supplemented to their target fiber dosage with either soluble fiber (Fruitafit Inulin) or placebo. Collection of blood serum, fecal samples, and nasal wash will aid in analyzing the microbes present in one’s gut and how fiber and diet may impact it. Thus, allowing researchers to better understand the pathways that may connect diet and asthma and if it is possible to improve asthma by altering one’s diet. |
MATTHEW RANK; | 2026-03-04 |
| 135 | Standardization According to GINA 2025 Recommendations for The Treatment, Management, and Follow-up of Acute Asthma Attacks: Observational, Multicenter Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Standardization According to GINA 2025 Recommendations for the Treatment, Management, and Follow-up of Acute Asthma Attacks: Observational, Multicenter Cohort Study. |
GRAZIA FENU; | 2026-02-17 |
| 136 | Efficacy & Safety of Piroxicam Plus Counterirritant Gel Compared With Other Topical Non-Steroid Anti-Inflammatory Drugs in Managing Musculoskeletal Pain: A Randomized Clinical Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if a gel containing Piroxicam plus Counterirritant (warming/cooling ingredients) is as effective and safe as two other common anti-inflammatory gels for treating acute muscle, bone, and joint pain in adults aged 18-60. The main questions it aims to answer are: Does the Piroxicam plus Counterirritant gel provide a similar level of pain relief as the standard Piroxicam-only gel and the Diclofenac gel? Is the Piroxicam plus Counterirritant gel as safe to use as the other two gels? Researchers will compare three groups of participants, … |
ERICA KHOLINNE; | 2026-03-16 |
| 137 | A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Single Ascending and Multiple Ascending Dose Study Investigating PRA-216 in Healthy Volunteers Followed By A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study in Participants With Mild-to-Moderate Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Phase 1 of this study will consist of 2 parts * Part 1 will evaluate the safety, tolerability, pharmacokinetics and immunogenicity of PRA-216 in healthy volunteers through single ascending dose administered by either intravenous (IV) or subcutaneous (SC). * Part 2 will evaluate the safety, tolerability, pharmacokinetics (PK) and immunogenicity of PRA-216 in healthy volunteers with repeat doses of multiple ascending dose administered subcutaneously. Phase 2a of this study is a randomized, double-blind, placebo-controlled study to investigate the efficacy, … |
PRANA THERAPIES | 2026-03-20 |
| 138 | Esmolol Versus Sufentanil on The Quality of Recovery After Laparoscopic Cholecystectomy During Anaesthesia With Orotracheal Intubation on An Outpatient Basis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: There are 120,000 outpatient laparoscopic cholecystectomies with orotracheal intubation per year in France. Sufentanil is the most commonly used morphine during surgery in France, but morphines have harmful effects when administered for surgery. As with other morphine-based analgesics (painkillers), sufentanil can be associated with nausea and vomiting, confusion, itching and addiction. There is an approach to anaesthesia which aims to eliminate the use of morphine in order to avoid its side effects, … |
UNIVERSITY HOSPITAL LIMOGES | 2025-09-15 |
| 139 | A Multicenter Registry Study Examining The Efficacy of Specific Immunotherapy Guided By Component-Resolved Diagnosis for Dust Mite Allergens in Chinese Pediatric Patients With Rhinitis And/or Asthma（EXPLORER STUDY） PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a Study to Understand How to Better Match Allergy Shots to a Child’s Unique Mite Allergy Profile 1. Why is this study being done? For many children, tiny house dust mites are a major cause of persistent allergies, leading to uncomfortable symptoms like a stuffy nose, sneezing, and even asthma. A common long-term treatment is allergy shots, also known as allergen immunotherapy (AIT). These shots work like a vaccine, slowly training the body’s immune system to stop overreacting to mites. However, … |
TANG LANFANG; | 2026-03-09 |
| 140 | Biomarkers and Respiratory Omics As New CHildren Opportunities – Study of Clinical Outcomes and Predictivity Evaluation – A Multi-cohort, Multi-center Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to improve the identification of biomarkers that predict disease progression and to assess the effectiveness of current therapies in children with asthma and protracted bacterial bronchitis. The main aim of the study is to evaluate the microbiome composition and diversity, cellular composition, and metabolomic profile. In addition, to assess their correlation on subsequent treatment and disease course in children with asthma, protracted bacterial bronchitis, and in those receiving inhaled glucocorticosteroids without a diagnosis of asthma. Participants will undergo fiberoptic bronchoscopy. During bronchoscopy, … |
WOJCIECH FELESZKO; | 2025-11-18 |
| 141 | Implementation of A Joint Pulmonologist and ENT Consultation in The Care Pathway of Patients Suffering From Asthma and Chronic Rhinosinusitis With Nasal Polyposis: Effectiveness Compared With Consultations By Specialty (CON-PO Study) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma affects the lower respiratory tract (bronchi), whereas chronic rhinosinusitis with nasal polyposis (CRSwNP) involves the upper airways. Despite this anatomical distinction, the upper and lower airways form a continuous respiratory tract and share common pathophysiological mechanisms. Consequently, asthma and CRSwNP frequently coexist, and several therapeutic strategies are effective for both conditions. Given these overlaps, we hypothesize that a multidisciplinary consultation involving both a pulmonologist and an ENT specialist could be more effective than separate consultations for patient care. We also believe that this innovative organization that would benefit the healthcare system. To test this hypothesis, … |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE | 2025-09-22 |
| 142 | Blomia Tropicalis Allergen Extract. Determination of The Vivo Histamine Equivalent Prick Test Units PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective is to assess the concentration of Blomia tropicalis allergenic extract that induces a wheal of size equivalent to that produced by a 10 mg/mL histamine dihydrochloride solution, in order to be used as in-house reference preparation (IHRP). |
MARÍA INMACULADA SÁNCHEZ MACHÍN; | 2025-10-02 |
| 143 | Evaluation of The Clinical Efficacy of PURESSENTIEL Allergy Protection Nasal Spray (SNPA®) in House Dust Mite Allergic Rhinitis- ACARAY Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Justification of the relevance of the research: Patients suffering from allergic rhinitis are looking for several therapeutic options to control their symptoms. Although etiological treatment is based on allergen immunotherapy, and most prescribed symptomatic therapies include antihistamines and/or topical corticoids, patients tend to self-medicate and seek different options, also choosing non-pharmacological approaches, particularly when symptoms are milder; nevertheless, accurate and reliable information on non-conventional therapies remains limited. Main research hypothesis and objectives: The present study, … |
PASCAL DEMOLY; | 2025-09-29 |
| 144 | Study of High-velocity Nasal Insufflation Versus Non-invasive Positive Pressure Ventilation for Emergency Type 2 Respiratory Failure: A Non-inferiority Randomized Controlled Trial (The SHINE Trial) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if high velocity nasal insufflation (HVNI) is comparable to non-invasive positive pressure ventilation (NIPPV) in treatment of emergency patients with acute respiratory acidosis. In our non-inferiority trial, … |
MUI TENG CHUA; | 2025-07-15 |
| 145 | Effect of Aquatic Exercises on Muscle Strength and Quality of Life in Children With Sickle Cell Anemia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Sickle cell anemia is a global public health disorder that affects millions of people across the globe. It is an inherited autosomal recessive hemoglobin condition caused by a beta-globin gene mutation that results in an aberrant sickle cell hemoglobin molecule with glutamic acid replaced by valine at position six of the beta-globin chain. Sickle cell anemia is a hereditary illness characterized by persistent microvascular blockage by sickle-shaped cells, chronic hemolytic anemia, and tissue destruction. Red-cell dehydration, hypoxemia, metabolic acidosis, and hyperthermia are typical vaso-occlusive triggers. Children with sickle cell anemia frequently have poor growth and nutritional status, increased protein turnover, … |
EMAN SAMIR SHALTOUT; | 2026-01-06 |
| 146 | Physiological, Sensory and Ergogenic Effects of Salbutamol – Implications for Athletic Screening and Β2 Agonist Use in Sport PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: β2-Agonists, commonly used to treat asthma, have also been used by athletes to enhance performance, leading to their ban by the International Olympic Committee in 1972. Research has shown non-asthmatics receive no benefit from these drugs at therapeutic dosages; however, many elite athletes still use them, and asthmatic athletes often win more Olympic medals. In some non-asthmatics, β2-agonists may improve breathing limitations during high intensity exercise, which may improve performance. Therefore, we aim to examine if there is a select group of non-asthmatic individuals who experience breathing limitations that may receive benefit from β2-agonists. |
JORDAN GUENETTE; | 2026-03-13 |
| 147 | 6-year Follow-up of Children Born to Mothers Exposed to Nifedipine Vs Placebo After Preterm Prelabor Rupture of Membranes at 22 to 33 Weeks of Gestation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the neurodevelopment at age 6 of children born to women with preterm prelabor rupture of membranes at 22 to 33 weeks of gestation, after antenatal exposure to nifedipine vs placebo. |
GILLES KAYEM; | 2026-02-13 |
| 148 | A Phase 2, Multicenter, Randomized, Double-blind, 52-week Study, to Investigate The Efficacy and Safety of Brenipatide Compared With Placebo for The Treatment of Adult Participants With Uncontrolled Moderate to Severe Asthma PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess the safety and efficacy of brenipatide at different dose levels compared with placebo in participants with moderate-to-severe asthma. Study participation will last approximately 65 weeks, including screening, treatment, and follow-up periods. |
WILLIAM REEDY; | 2026-03-20 |
| 149 | Beyond Eosinophils: Proteomics to Identify Potential Biomarkers of Organ Damage and Response to MEPOLIZUMAB in EGPA PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Aim of the study is to identify potential biomarkers, through a proteomic approach, which could be used to evaluate organ damage and predict the response to mepolizumab in a cohort of patients affected by EGPA. Proteomic analyses will be performed using a proteomic platform, based on a nano-HPLC- couplet to an high resolution ESI-MS device, on three types of biological matrices: blood, saliva and sputum samples in both EGPA and severe asthmatic patients (as controls) at baseline and at different time points after starting treatment with mepolizumab, an anti-IL-5 drug, … |
GIULIA COSTANZO; | 2026-01-15 |
| 150 | Isometric Versus Isotonic Trunk Muscle Strength Training on Lung Function in Heavy Smokers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Smoking is a major public health concern, significantly affecting lung function and overall respiratory health. Heavy smoking leads to chronic obstructive pulmonary disease (COPD), emphysema, and a decline in lung capacity. Exercise interventions, particularly those targeting the trunk muscles; have demonstrated potential in improving respiratory function. Trunk muscle strength is essential for optimal breathing mechanics, as these muscles support the chest wall and aid in the expansion and contraction of the lungs. There are two primary types of muscle strength training: isometric and isotonic. Isometric exercises involve static contractions where the muscle length does not change, … |
MTI UNIVERSITY | 2026-01-23 |
| 151 | Energy Recovery Ventilation and Air Cleaner Interventions to Improve Indoor Air Quality, Mold Control, and Asthma-Related Health Outcomes Among Inner-City Children and Adults in Low-Income Households PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary goal of this study is to investigate the comparative long-term (i.e., 1-year) effectiveness of energy recovery ventilators (ERVs) and portable air cleaners (PACs) in reducing indoor air pollutants and mold levels and improving asthma-related health outcomes in inner-city children and adults with asthma in low-income households in the Dallas-Fort Worth (DFW) metropolitan area, TX. Secondary goals include: (1) examining associations among asthma outcomes, exposure to indoor air pollutants and mold, and housing-related factors, (2) conducting a cost-benefit analysis of ERV and PAC interventions for improving IAQ, mold control, and health outcomes, … |
INSUNG KANG; | 2025-10-29 |
| 152 | Inhaler Trainer Efficacy Study: Interactive Training Tool Providing Technique Feedback for COPD/Asthma Medication Delivery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This will be a randomized, controlled, clinical trial. The investigators aim to determine the feasibility of and efficacy of the Inhaler Trainer Device for ongoing inhaler skill training. The research team will enroll 140 patients from the inpatient or outpatient setting from the University of Chicago Medicine over the course of up to 12 months. Participants will complete assessments, a lung function test via spirometry, and inhaler education via either the Inhaler Trainer Device learning program or Brief Intervention. All participants will return at 6 weeks (window of +/- … |
KORONIS BIOMEDICAL TECHNOLOGIES | 2025-10-14 |
| 153 | Improving Chronic Disease Outcomes Across The Lifespan By Addressing Structural Racism PF:9 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if the implementation of the WE CARE social determinants of health (SDOH) screening and referral intervention with an antiracist lens in primary care settings can lead to a meaningful decrease in chronic disease by monitoring conditions such as hypertension, diabetes, depression, hyperlipidemia, and asthma through clinical measures. The main question it aims to answer is: Does the WE CARE SDOH screening and referral intervention applying an antiracism lens informed implementation strategies have the potential to reduce racial/ethnic health inequities in chronic diseases for minoritized patients? |
ARVIN GARG; | 2025-11-10 |
| 154 | Magnesium Trial in Acute Asthma in Emergency Department PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Despite optimal initial emergency department (ED) therapy, 50% of children with severe acute asthma have ongoing moderate-severe respiratory distress. Guidelines recommend intravenous magnesium (IVMg) for them, yet evidence for IVMg efficacy is scant and disparate. While early small Randomized Controlled Trials (RCTs) suggested hospitalization benefit, recent large observational studies found no association between IVMg and improved outcomes. IVMg therapy is resource-intensive, can cause hypotension and demands close monitoring. Previous RCTs only assessed early Mg effect at 1-2 hours, … |
SUZANNE SCHUH; | 2025-12-18 |
| 155 | EFFICACY OF INDONESIAN ASTHMATIC GYMNASTIC AS COMBINE PULMONARY REHABILITATION IN ASTHMATIC PATIENT BASED ON ASTHMA CLASSIFICATION PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the efficacy of Indonesian Asthma Gymnastic for stable asthmatic patients in all asthma classification. The outcome measurements includes 6 minutes walk test, Asthma Control Test, peak flow rate value, and lung function. All participants have been in routine standard treatment of asthma (medication, education of healthy life style and smoking cessation). |
RSUP PERSAHABATAN | 2026-03-18 |
| 156 | ROLL’YN-OMA : Etude Observationnelle De Cohorte Pour La Prise En Charge Des Patients Atteints De Pathologies Inflammatoires Chroniques Traités Par Omlyclo®, Un Omalizumab Biosimilaire PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: ROLL’YN-OMA is a real-world study in patients receiving standard biologic therapies who have been in control and/or remission of their disease for at least 3 months and whose physician has independently decided, within the framework of a shared medical decision, to switch them to OMLYCLO®. The primary objective of this study is to evaluate the maintenance of this control and/or clinical remission 12 months after initiation of the biosimilar, and subsequently, patient satisfaction at 6 and 12 months. |
CELLTRION HEALTHCARE FRANCE | 2026-02-23 |
| 157 | Comparison of Gastric Insufflation Volume Between LarySeal Pro and Ambu AuraGain Using Ultrasonography In Pediatric Patients Undergoing General Anesthesia With Controlled Ventilation. A Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Gastric air insufflation during insertion of a laryngeal mask airway (LMA) is a known phenomenon and can have important clinical implications, especially in relation to: During positive pressure ventilation or improper insertion technique, air can be forced into the esophagus and stomach or LMAs do not fully seal the esophagus, so high ventilation pressures or incorrect placement may lead to gastric insufflation. Which may lead to Increased risk of regurgitation and aspiration, especially if the gastric contents reach the upper esophagus, Abdominal distension, which can reduce ventilation efficiency, nausea, vomiting, … |
MAHMOUD GBRE; | 2026-03-05 |
| 158 | REverse LuNg Airway and Vascular RemOdeling in Asthma ReMission (ReNORM) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this program of research, the investigators aim to answer the question: In patients with asthma aged 18-80, how do the lung airways and vessels respond to biologic therapy and what role does age and asthma duration have in this response? While about 4.6 million Canadians live with asthma, \~5-10% of patients have severe asthma meaning that multiple inhaled and systemic oral corticosteroid treatments have failed to improve symptoms and exacerbations, leading to lost work and school days and substantially diminished ability to participate in normal life. For such people, … |
GRACE PARRAGA; | 2025-09-16 |
| 159 | Effect of Tezepelumab on Barrier Function in Severe Asthmatic Patients With and Without Comorbid Chronic Rhinosinusitis With Nasal Polyps – An Exploratory Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, we will investigate the effect of tezepelumab on the epithelial barrier function of the upper and lower airways in patients suffering from severe asthma with and without chronic rhinosinusitis with nasal polyps. This will be achieved by analysis of epithelial barrier function upon challenge with various harmful substances (e.g. cigarette smoke extract, allergens) in cultured primary respiratory tract epithelial cells. Furthermore we will assess changes in clinical parameters, cellular composition and inflammatory mediators. |
MARCO IDZKO; | 2025-07-01 |
| 160 | Towards Digital Management of Pediatric Asthma:a Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This pilot study aims to explore whether a digital approach to managing childhood asthma using connected inhalers and video consultations triggered by alerts from these devices – could work as well as standard in-person care. The connected inhalers track when children use their daily prevention medication and their rescue medication for asthma symptoms. If a child misses several days of prevention medication or uses their rescue inhaler frequently, their doctor receives an alert and can schedule a video consultation to adjust their treatment. Fifty children aged 4-12 years with asthma will participate for 8 months, … |
DAVID DUMMOND; | 2025-05-02 |
| 161 | Evaluation of The Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study evaluates the diagnostic performance, usability, and clinical utility of the Medentum Diagnostik platform, a multisensor device with integrated software and artificial intelligence, in pediatric patients with asthma and ENT conditions. Participants will be assigned to either home-based use of the Diagnostik platform with telehealth-supported clinician evaluation or standard in-person care. The primary objective is to assess agreement between AI-generated diagnoses and clinician diagnoses obtained during study encounters, including telehealth evaluations in the Diagnostik arm and in-person evaluations in the standard-of-care arm. Secondary objectives include evaluating agreement between AI-generated diagnoses and independent research team diagnoses, … |
MEDENTUM INNOVATIONS | 2026-03-30 |
| 162 | Estudio Piloto Para La Aplicación De Dispositivos Bioelectrónicos Externos De Baja Potencia En El Diagnóstico De Asma Bronquial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to detect the acoustic signals generated by the respiratory system on asthma patients using an acoustic sensor and retrospectively use these signals to identify the characteristics that differentiate patients with asthma and healthy subjects. |
M. AUXILIADORA ROMERO FALCON; | 2025-08-19 |
| 163 | Effect of Glycomacropeptide on Clinical Manifestations of Atopic Dermatitis in Children: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the protective effect of glycomacropeptide on the clinical signs and symptoms of atopic dermatitis in children aged 2 to 12 years, … |
EVA MARÍA SALINAS MIRALLES; | 2025-12-02 |
| 164 | Conducting A Randomized Controlled Trial for A Novel Patient-Facing Mobile Platform to Collect and Implement Patient-Reported Outcomes and Voice Biomarkers in Underserved Adult Patients With Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to conduct a randomized controlled trial (RCT) to compare the adapted and refined ASTHMAXcel Voice platform to usual care (UC). It is hypothesized by the investigator team that ASTHMAXcel Voice will be associated with improved clinical and process outcomes, asthma quality of life (QOL), medication adherence, and self-efficacy as compared to UC. |
SUNIT JARIWALA; | 2025-10-24 |
| 165 | A Combined Prospective, Multicenter, Non-Randomized, Open-Label, Point-of-Care and Home Use Pivotal Study of The FenoTRACK Device for Monitoring Changes of Fractional Exhaled Nitric Oxide (FeNO) in Non-Steroid-Treated Adult and Pediatric Uncontrolled Asthma Subjects and A Prospective Multicenter Clinical Precision Evaluation for Point-of-Care and Home Use in Adult and Pediatric Controlled Asthma Subjects PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study incorporates objectives directed at two subject cohorts: 1. Uncontrolled Adult and Pediatric Asthma Subjects: To demonstrate a statistically significant and clinically meaningful decline in Point Of Care (POC) FeNO as measured by the fenoTRACK device, after an approximately 2-week course of corticosteroid therapy in adults and children with non-steroid treated uncontrolled asthma. 2. Controlled Adult and Pediatric Asthma Subjects: * To evaluate within-session clinical precision during Visit 1 and Visit 2 for the fenoTRACK device for simulated at home FeNO, and at POC * To evaluate within-session clinical precision for home fenoTRACK use |
PHILIP E. SILKOFF; | 2026-03-24 |
| 166 | The Safety and Toxicity of Inhaled Ciclesonide (i.e., Alvesco) in Preterm Infants at Risk for Developing Bronchopulmonary Dysplasia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Our overall objective is to conduct a safety study with inhaled ciclesonide to evaluate known glucocorticoids (sGC)-related acute and intermediate toxic effects while measuring for the first time in neonates its systemic absorption and potential bioactivity (i.e. activation of primary target, the GR, in blood cells). |
VENKATESH SAMPATH; | 2026-03-27 |
| 167 | An Observational Multi-Country Post-Authorisation Safety Study to Evaluate The Risk of Serious Adverse Cardiovascular Events in Adolescent and Adult Patients With Severe Asthma Taking Tezepelumab PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the risk of serious adverse cardiovascular events in adolescent and adult patients with severe asthma taking tezepelumab compared to a population receiving standard of care treatment for severe asthma. |
PETER EGGER; | 2026-03-04 |
| 168 | A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are characterised by lung inflammation and remodelling. Clinical, functional, microbiological, biological, pathological and prognostic features are highly variable and heterogeneous. Several phenotypes have been described within the same pathology, as similar phenotypic traits between different pathologies, or the coexistence of components of several diagnoses in the same patient, suggesting shared underlying mechanisms that could represent new therapeutic targets, beyond the initial medical diagnosis. The objectives of this prospective study are to analyze the phenotypic characteristics (clinical, … |
CHU DE REIMS | 2026-02-20 |
| 169 | A 52-week, Multicentre, Observational, Prospective Study on The Use of A Smart Platform Connected to A Single-inhaler Triple Therapy (ICS/LABA/LAMA) to Evaluate Effectiveness on Treatment Adherence and Inhaler Technique in Patients With Poorly Controlled Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to determine if using the SiA® (Systematic Intervention Agent) system can improve inhaler technique and medication adherence in adults with asthma who are already using Trimbow pMDI inhalers. Furthermore, it will be addressed if the SiA® system can be used to discriminate between patients, … |
JOHANNES M SCHMID; | 2025-09-05 |
| 170 | Evaluation of The Validity and Reliability of The Londrina Activities of Daily Living Protocol in Patients With Pulmonary Hypertension PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this observational study is to evaluate the validity and reliability of the Londrina Daily Living Activities Protocol in patients diagnosed with pulmonary hypertension (PH). |
PINAR BASTURK MERC; | 2025-11-25 |
| 171 | A Multicentre, Randomized, Double-blind, Placebo-controlled, Parallel Group Phase Ⅲ Study to Evaluate The Efficacy and Safety of SHR-1905 in Subjects With Severe Uncontrolled Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a phase III study of SHR-1905 in subjects with severe uncontrolled asthma. The purpose of the study is to evaluate efficacy and safety of SHR-1905 in subjects with severe uncontrolled asthma. |
NANSHAN ZHONG; | 2025-09-09 |
| 172 | Single Maintenance And Reliever Therapy Strategies for IMPLementation and Effectiveness (SMART & SIMPLE) Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: While single maintenance and reliever therapy (SMART) has been the preferred management strategy for Step 3 and 4 (moderate/severe) asthma management since the 2020 NIH asthma guideline updates, adoption of SMART has not been rigorously assessed. This study will test electronic medical record clinical decision support and education implementation strategies (CDS+) to increase adoption of SMART in pediatric primary care. This is the first of two related records. |
CHILDREN’S HOSPITAL OF PHILADELPHIA | 2025-09-17 |
| 173 | Single Maintenance And Reliever Therapy Strategies for IMPLementation and Effectiveness (SMART & SIMPLE) Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: While single maintenance and reliever therapy (SMART) has been the preferred management strategy for Step 3 and 4 (moderate/severe) asthma management since the 2020 NIH asthma guideline updates, adoption of SMART has not been rigorously assessed. This study will test population health management (PHM; asthma community health worker, asthma nurse care manager) implementation strategies building on electronic medical record clinical decision support and education implementation strategies (CDS+), to increase adoption of SMART. This is the second of two related records. |
CHILDREN’S HOSPITAL OF PHILADELPHIA | 2025-09-17 |
| 174 | Investigation of The Effectiveness of Social Media-Based Support in Developing Healthy Lifestyle Behaviors in Pregnancy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to examine the effectiveness of a programme to improve healthy lifestyle behaviours based on the Health Belief Model to be offered through Instagram, a social media platform. For this purpose, it is aimed to produce content containing accurate and evidence-based information for pregnant women on social media, to ensure that pregnant women can access the right information quickly and easily, to adopt healthy lifestyle behaviours, … |
OZLEM TAS; | 2025-06-04 |
| 175 | A Phase 4, Multicenter, Cluster Randomized, Open-label, Intervention Versus Usual Care, Controlled Study on The Effect of Emergency Department Initiation of Airsupra on Asthma Outcomes PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a randomized controlled trial on the effect of emergency department initiation of Airsupra on acute asthma recurrence at 3 months and other related outcomes (acute asthma relapse, asthma control). |
CARLOS A. CAMARGO; | 2025-09-17 |
| 176 | Evaluating Care Pathways for Chronic Respiratory Diseases in Brazil PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators aim to investigate how individuals attending primary healthcare (PHC) services in Brazil for treatment of non-communicable diseases (NCDs), identified there as having abnormal spirometry or as being at high risk for lung health problems (such as asthma and chronic obstructive pulmonary disease-COPD, collectively referred to as chronic respiratory disease (CRDs)) using the COLA-6 questionnaire, … |
JOHN R HURST; | 2025-08-21 |
| 177 | A Randomised Double-blind Placebo-controlled Phase III Field Trial Evaluating The Efficacy and Safety of The House Dust Mite (HDM) SLIT-tablet in Chinese Participants Aged 12-65 Years With HDM Allergic Rhinitis/Rhinoconjunctivitis With or Without Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A research study of house dust mite (HDM) SLIT-tablet for the treatment of HDM allergy in Chinese participants aged 12-65. |
CHENGSHUO WANG; | 2025-12-31 |
| 178 | Chronic Obstructive Pulmonary Disease and Asthma in Workers at Navanakorn Industrial Zone, Thailand PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to determine the prevalence of asthma and chronic obstructive pulmonary disease (COPD) among workers in an industrial zone in Thailand. The main question the study aims to answer is: What is the prevalence of asthma and COPD among workers in Thailand? Participants will complete a questionnaire on respiratory symptoms and undergo pulmonary function testing. |
NARONGKORN SAIPHOKLANG; | 2026-02-03 |
| 179 | Open-label Randomized Controlled Trial Investigating The Relationship Between Obstructive Sleep Apnoea and Difficult Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The OSADA (Obstructive Sleep Apnoea in Difficult Asthma) trial is an open-label, randomized control trial investigating the impact of diagnosing and treating obstructive sleep apnoea (OSA) on a asthma control in patients with difficult-to-control asthma. Participants will undergo home-based sleep studies to assess for OSA and are then allocated to one of three arms: 1) Patients with OSA treated with CPAP (intervention group), 2) Patients with OSA not treated for OSA (control group) and 3) Patients without OSA (reference group). The primary objective is to evaluate whether treating OSA improves asthma control, symptom burden, … |
LAURA PIGGOTT; | 2025-09-08 |
| 180 | PAXT: Pulmonary Imaging of Mild Asthma Using 129Xe MRI and Tc-99-Labeled-Carbon-Imaging (Tc99CImaging) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to better understand how asthma affects the lungs in young adults (ages 17-35) with mild asthma. The main questions it aims to answer are: * Can advanced imaging detect abnormal airway function in people with mild asthma? * Do changes in ventilation imaging correlate with asthma symptoms or quality of life? Researchers will compare hyperpolarized xenon-129 MRI and Technegas (Tc-99m) imaging to see if these techniques reveal more detailed lung abnormalities than standard lung function tests. Participants will: * Complete a single 2-hour visit * Undergo two types of lung imaging: Hyperpolarized xenon-129 MRI (to visualize how air moves in the lungs), Technegas (Tc-99m) imaging (to assess airflow using nuclear medicine) * Perform spirometry and other breathing tests * Answer questionnaires about asthma symptoms and quality of life This study is designed to improve our understanding of subtle changes in lung function that may not be detected by standard tests in people with mild asthma. The findings may lead to better diagnostic tools and more personalized treatment strategies in the future. |
GRACE PARRAGA; | 2025-08-27 |
| 181 | Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers – A Randomized, Double-blind, Placebo-controlled, Cross-over Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This planned study is based on a randomized, placebo-controlled cross-over design. Boswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian Ayurvedic medicine system as antioxidants and anti-inflammatory agents for treating conditions such as rheumatoid arthritis, chronic bronchitis, asthma, and chronic inflammatory bowel diseases (ulcerative colitis and Crohn’s disease). The β-configured pentacyclic triterpenic acids in B. serrata include 3-acetyl-11-keto-β-boswellic acid (AKBBA), 11-keto-β-boswellic acid (KBBA), β-boswellic acid (BBA), and 3-acetyl-β-boswellic acid (ABBA). These compounds, which constitute approximately 14% of the lipophilic fractions of the B. serrata extract, … |
MEDICAL UNIVERSITY OF GRAZ | 2025-09-24 |
| 182 | Respiratory Health and Wellbeing Post Pulmonary Tuberculosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: We know that in low-income countries where there is a lot of tuberculosis (TB) about 20%-50% of people treated for TB have long term problems with their lungs and general wellbeing. This means they can’t always get back to doing activities they were doing before they had TB and may need further treatment, for example antibiotics, inhalers or special rehabilitation classes. Some people are unnecessarily treated again for TB because they still have a cough. There have been two international guides published recently, describing standards for providing follow up care for people treated for TB. However, … |
LIVERPOOL SCHOOL OF TROPICAL MEDICINE | 2025-09-17 |
| 183 | Healing Minds II: Biofeedback, Breathing Practices, Nutrition and Exercise Counseling in Children and Adolescents With ADHD Related Papers Related Patents Related Grants Related Experts Highlight: The Pediatric Healing Minds II intervention includes a biofeedback component, breathing practices nutrition and exercise counseling. Biofeedback is a type of mind-body technique used to control body functions such as heart, lung and muscle responses. Biofeedback uses therapeutic techniques that aim to help study participants gain more awareness and control over certain physiological functions in their bodies. It involves the use of electronic monitoring equipment to provide real-time information about physiological processes such as heart rate, HRV, coherence and muscle tension. This information is then provided back to the study participant, … |
INARA MCMASTER; | 2026-01-28 |
| 184 | Effect Of Virtual Reality On Pulmonary Function And Anxiety Levels In Asthmatic Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Purpose of the Study This study will be conducted to determine the effect of virtual reality on pulmonary function and anxiety levels in moderate to severe asthmatic patients. |
MAI GOMAA MOHAMED ABDELRAHMAN; | 2025-08-26 |
| 185 | Impact of Holotropic Breathwork on Nursing Student Mental Health Related Papers Related Patents Related Grants Related Experts Highlight: Purpose of the Study This study investigates whether Holotropic Breathwork (HB)-a technique involving controlled hyperventilation paired with music and guided support-can improve the mental, emotional, and existential well-being of nursing students. The researchers aim to: Evaluate the acceptability and impact of HB in this population. Compare psychological, interpersonal, and existential functioning before and after the breathwork session. Study Design Participants: Up to 72 current UNMC nursing students (age 19+), excluding those with bipolar/psychotic disorders, cardiac/seizure conditions, glaucoma, or recent surgeries. Pregnant individuals are excluded. Intervention: A single-day breathwork session, led by certified facilitators, including preparatory instruction, … |
UNIVERSITY OF NEBRASKA | 2026-03-04 |
| 186 | Real-word Study to Assess Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays. The main questions it aims to answer are: * Efficacy, * Safety, * Usage, * Satisfaction, in real-life usage among infants, children, adults and pregnant or breastfeeding women suffering from acute and chronic sinonasal pathologies. The 4 medical devices under investigation will be used in accordance with their intended use, target populations and medical indications. |
LABORATOIRE DE LA MER | 2025-12-03 |
| 187 | Creating A RIsk Assessment Biomarker Tool to Prevent Seasonal and Thunderstorm Asthma: The CARISTA Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Thunderstorm asthma is a recurring public health emergency in South-Eastern Australia which occurs in springtime. The major identified risk factors for thunderstorm asthma is hay fever and allergy to ryegrass pollen. The goal of the CARISTA study is to identify the risk of springtime allergic and thunderstorm asthma in allergic adults living in South-Eastern Australia. To do this the investigators will recruit 530 people who have hay fever and test them for allergy to ryegrass pollen and undertake simple lung function testing. The investigators will ask study participants to complete a customised symptom tracker over the springtime pollen season for 2 consecutive years. The outcome the investigators are looking for is an asthma exacerbation or worsening asthma symptoms. This study will enable the investigators to identify indicators (biomarkers) of severe and moderate asthma exacerbations in order to identify those at risk of thunderstorm and seasonal asthma so protective treatments and strategies can be advised. |
PHILLIP BARDIN; | 2025-09-04 |
| 188 | Can The Quality of Life of Adolescents With Asthma Be Improved By Focusing on Improving Their Asthma Self-management PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: BACKGROUND: Asthma is a long-term lung condition affecting 1 in 11 children and young people in the UK. Many teenagers have well controlled asthma, but a significant number continue to experience regular symptoms and asthma attacks leading to hospitalisations. While non-adherence to medication is a factor, teenagers also face challenges like changing relationships with parents and peers, avoiding triggers like smoking, and fitting in treatment with daily life demands. Healthcare professionals (HCPs) also face difficulties in managing teenagers with asthma. A previous study, funded by Asthma + Lung UK, … |
UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST | 2026-01-05 |
| 189 | Validation of A Chronic Obstructive Pulmonary Disease (COPD) Predictive Algorithm PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Under-diagnosis of Chronic Obstructive Pulmonary Disease (COPD) is prevalent, with an estimated 75% of adults suffering from COPD in the US, without clinical recognition. Often, the first diagnosis of COPD comes with a flare or exacerbation. In one study, 34% of patients were first diagnosed during hospitalization for an exacerbation, an event associated with a 1-year mortality rate of 26%. When COPD is finally diagnosed, it is often in the late stages, with an average lung function of 50% of normal. Conversely, COPD can be over-diagnosed, … |
BRIAN J WELLS; | 2025-11-03 |
| 190 | Additional Effects of Scalene Hold Relax Technique With Conventional Physical Therapy On Pulmonary Function in Asthma Patient PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To determine the additional effects of scalene hold relax technique with conventional exercises on pulmonary function in asthma patients |
MUHAMMAD IQBAL TARIQ; | 2025-08-22 |
| 191 | Comparative Effects of Buteyko Versus Pilates Breathing Combined With McKenzie Neck Exercises on Lung Function and Chest Expansion in Asthmatic Patients With Forward Head Posture PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Asthma is characterized by airway inflammation and hyperinflation that flattens the diaphragm and increases reliance on accessory neck muscles. Chronic overuse shortens these muscles and promotes forward head posture (FHP), which in turn compromises rib-cage motion and respiratory mechanics. Correcting FHP alongside breathing retraining may therefore improve lung function and symptoms in asthma. This interventional, parallel-group study investigates the combined effects of McKenzie neck exercises with two different breathing approaches on lung function, chest expansion, posture, … |
FOUNDATION UNIVERSITY ISLAMABAD | 2025-12-17 |
| 192 | Safety and Immunogenicity of Cat-allergen Intralymphatic Immunotherapy: An Open Label Phase II Study in Patients With Cat Allergy With and Without Asthma PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the safety and tolerability of intralymphatic immunotherapy (ILIT) with ALUTARD SQ Felis domesticus in patients with cat allergy-induced allergic rhinitis and asthma. The main questions it aims to answer are: Is ILIT with ALUTARD SQ Felis domesticus safe and well tolerated? What immunological responses play a role in ILIT? Researchers will compare the effects of ILIT to existing subcutaneous immunotherapy (SCIT) approaches to assess safety, tolerability, immunogenicity, and efficacy. Participants will: Receive 3-4 ILIT injections of ALUTARD SQ Felis domesticus into an inguinal lymph node, guided by ultrasound. Undergo safety monitoring, … |
CLAUDIA V.L. LANG; | 2026-03-16 |
| 193 | Comparison of Effects of Alternate Nostril Breathing Exercise With Incentive Spirometer Technique on Lung Functions Among Asthma Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To compare effects of Alternate Nostril Breathing exercise with incentive spirometer on lung functions (forced vital capacity, forced expiratory volume, and peak expiratory flow rate) in Asthma patients. |
MUHAMMAD IQBAL TARIQ; | 2025-09-05 |
| 194 | A Randomized, Double-blind, Placebo-controlled Phase II Clinical Study Evaluating The Efficacy and Safety of CM512 Injection in Subjects With Moderate-to-severe Asthma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a multicenter, randomized, double-blind, placebo-controlled phase II clinical trial evaluating the efficacy, safety, pharmacokinetics, pharmacodynamics, and immunogenicity of CM512 in subjects with moderate-to-severe asthma. |
RUCHONG CHEN; | 2025-08-28 |
| 195 | Accuracy, Validation, and Usability of An Intelligent Respiratory Pattern Monitoring System in Patients at Risk of Acute Respiratory Failure PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: The monitoring of respiratory patterns is crucial in the management of respiratory diseases, but in many cases, it still relies on subjective and visual assessment. The use of healthcare technologies based on artificial intelligence (AI) can, in these contexts, enhance clinical decision-making by providing a more objective and accurate analysis. Given the high prevalence of acute and chronic respiratory diseases, the implementation of a device capable of detecting variables such as flow, volume, and time becomes a priority for more effective diagnosis and therapeutic planning. Objective: Evaluate the accuracy, validity, … |
SHIRLEY LIMA CAMPOS; | 2025-09-10 |
| 196 | Clinical Evaluation of Montelukast on Cognitive and Mood Dysfunction and Neuroinflammation in Veterans With Gulf War Illness (GWI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study addresses the pre-clinical promise of Montelukast (MLK) for improving brain function in veterans with Gulf War Illness (GWI). MLK, a US Food and Drug administration (FDA)-approved drug for asthma, has shown efficacy in an animal model of GWI to improve cognitive and mood function through modulation of leukotriene signaling and suppression of neuroinflammation. |
DREW HELMER; | 2025-08-20 |
| 197 | Aerobic Exercise and Pain Modulation: Examining The Impact on Pain Sensitivity in Healthy Adults PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Exercise-Induced Hypoalgesia (EIH) refers to reduced pain sensitivity following exercise, particularly in response to noxious stimuli. Various exercise modalities, including isometric, aerobic, and resistance training, contribute to this effect. Pain experienced during exercise may activate descending inhibitory pathways, leading to subsequent pain relief. Conditioned Pain Modulation (CPM) is a behavioral measure of diffuse noxious inhibitory control (DNIC), where pain inhibits pain. It is proposed that pain within the exercising limb may serve as a conditioning stimulus, activating CPM. For instance, maximal handgrip exercise has been used to trigger CPM responses. In clinical settings, unpleasant physical therapy interventions like exercise, … |
PRIYANKA RANA; | 2025-12-10 |
| 198 | A New Intervention to Improve Function in Veterans With Anxiety and Depression PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Anxiety and depression symptoms occur at high rates in Veteran populations and can significantly impact function, compromising the ability to work and to successfully form and maintain valued relationships. Several other symptoms commonly occur with anxiety and depression, including poor sleep quality and chronic pain. Since all these symptoms frequently occur together, … |
JENNIFER C NAYLOR; | 2025-08-20 |
| 199 | A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Trial to Evaluate The Efficacy and Safety of Rademikibart As An Add-on Treatment for Acute Exacerbation in Adult and Adolescent Participants With Asthma and Type 2 Inflammation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase 2, randomized, multicenter study in adult and adolescent participants with asthma and type 2 inflammation |
CONNECT BIOPHARM | 2026-03-31 |
| 200 | A Study of Mild, Moderate and Severe Asthma: Characterisation of Phenotypes and Endotypes and Longitudinal Associations With Exacerbations, Triggers and Disease Progression (MAPLE-UK) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background and study aims: The purpose of this research registry is to understand how asthma varies from person to person and monitor changes that may occur over time. The effects that asthma has on the body will be assessed, by looking at different causes/triggers of flare-ups/exacerbations, asthma symptoms, … |
ALEXANDRE LIMA; | 2025-09-24 |