Clinical Digest: Recent Clinical Trials on Autism (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Autism. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Autism (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Quantitative 3D UltraSound Brain Imaging: Development of New Bedside Biomarkers to Better Predict Neurodevelopmental Outcomes in Preterm Infants PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Prematurity is a leading cause of neurodevelopmental disorders (NDDs) tightly associated with white matter damage, including punctate white matter lesions (PWMLs). Hence, an improved detection of brain injury early in life in infants born very preterm is a top priority to predict NDDs and therefore to assess potential neuroprotective strategies and implement early interventions. 3D and quantitative tools at the bedside using ultrasound are expected to better detect and quantify not only PWMLs but also other brain structures with promising prognostic value to predict NDDs at 2 years of age. |
OLIVIER BAUD; | 2026-02-18 |
| 2 | Sibwatch: Optimizing Intervention Options for Infants and Toddlers With A High Likelihood of Social Communication Delays and Language Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This rigorous randomized controlled trial will evaluate the efficacy and acceptability of a preemptive, telehealth intervention (tele-ImPACT) in a large, representative sample of infant siblings of autistic children, who are known to be at high likelihood of receiving a future diagnosis of autism and/or developmental language disorder (HL-Sibs). If our hypotheses are supported, this innovative and interdisciplinary study will provide empirical support for a novel approach to treatment that is theoretically motivated and developmentally informed, as well as accessible for and acceptable to families, and will lend new insights into the developmental windows in which, mechanisms by which, … |
LAUREN HAMPTON; | 2025-07-16 |
| 3 | Non-progressive Congenital Ataxia – Advancing Diagnosis to Enhance Chances for Targeted Therapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This multinational European observational clinical study focuses on non-progressive congenital ataxia (NPCA), a very rare early-onset neurological condition also within the cerebral palsy (CP) concept as ataxic CP. The study aims to improve the diagnosis and care of affected children through a comprehensive approach that integrates detailed clinical assessments, brain imaging analyses, and advanced genetic testing. By identifying developmental trajectories, specific impairment profiles, brain MRI patterns, and genetic variants, the researchers aim to elucidate underlying mechanisms, … |
KATE HIMMELMANN; | 2026-02-19 |
| 4 | Improving Caregiver Engagement in Early Interventions for Autistic Children Using A Mobile Health Approach PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to test the effectiveness of the FANS-EI program in supporting caregiver engagement in caregiver-mediated early interventions for young children with autism. This study also examines caregiver-perceived social support and self-efficacy and FANS-EI implementation outcomes (feasibility, acceptability, appropriateness). |
UNIVERSITY OF CALIFORNIA DAVIS | 2026-03-30 |
| 5 | Research on The Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Williams Syndrome (WS) is a rare neurodevelopmental disorder, usually caused by microdeletions of approximately 26 genes in the long arm (7q11.23) region of chromosome 7. Children with this syndrome often exhibit distinctive facial features, mild to moderate intellectual disability, impaired spatial cognition, pronounced social extraversion, and relatively reserved language-expression characteristics. Although individuals with WS often demonstrate strong social interest and prosocial behaviors, significant deficiencies in abstract thinking, executive function, and visuospatial ability are frequently observed. At present, treatment for WS mainly focuses on behavioral intervention and educational rehabilitation, … |
QILU HOSPITAL OF SHANDONG UNIVERSITY | 2026-04-03 |
| 6 | Milieu Teaching-AV: A Study to Assess An Adaptation of Milieu Teaching for Infant Siblings of Autistic Children That Encourages Looking to The Mouth PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project will look at Milieu Teaching (i.e., a language intervention) that encourages looking to audiovisual speech cues (Milieu Teaching-AV) for infants with autistic older siblings (Baby Sibs), who are highly likely be diagnosed with autism or developmental language disorder (DLD), compared to Milieu Teaching alone (Milieu Teaching-NoAV). This study will specifically look at whether Milieu Teaching-AV (compared to Milieu Teaching-NoAV) results in (a) increased looking towards caregivers’ faces, (b) increased communicative behaviors and language skill, and (c) increased engagement with the caregiver during play. We will also look at caregiver factors, … |
FATHER FLANAGAN’S BOYS’ HOME | 2026-03-27 |
| 7 | Family-Centered Implementation of Parent Training for Emotion Regulation in Autistic Toddlers Within The Part C Early Intervention System PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Early Intervention (EI) systems are ill-equipped to serve the many children 12 to 36 months with early signs or a diagnosis of autism spectrum disorder (ASD). EI funded by Part C of the Individuals with Disabilities Education Act (IDEA) uses home-based service delivery, emphasizes family-centered care, and prioritizes family-defined concerns (i.e., patient-centered outcomes). The Part C system is ideally situated to provide family-based intervention to children aged birth to three. However, Part C EI providers receive little training in ASD or the challenges characterizing ASD in toddlerhood, … |
SARAH ROSE EDMUNDS; | 2026-03-13 |
| 8 | A Pilot Study of Transcranial Direct Current Stimulation (tDCS) in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Although many children diagnosed with autism spectrum disorder (ASD) make significant progress in learning and their cognitive skills improve with applied behavior analysis (ABA), there are a significant number of children who show an absence or a plateau in various skills. Deficits in executive functioning are likely to be involved in many of these cognitive and learning disabilities due to poor functioning of the prefrontal cortex. Currently, … |
HELEN YOO; | 2026-02-23 |
| 9 | Supporting Patients With Autism Spectrum Disorder (ASD) During Needle-related Hospital Visits Through The Use of Behavior Analytic Strategies PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the effectiveness of the behavior analytic intervention in reducing the number of challenging behaviors exhibited by patients with Autism Spectrum Disorder (ASD) while increasing compliance with needle-related simulations and procedures. A second purpose is to assess the social validity of this study as evidenced by patient and/or caregiver acceptability. The study wil take place at Boston Medical Center (BMC). A Single Subject Design (SSD) wil be utilized as it allows for detailed, … |
JACQUELINE MCKENDRY; | 2026-04-02 |
| 10 | Breathing and Decision-Making (ProlEx-Context) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The ProlEx-Context study aims to investigate how a slow-paced breathing technique with prolonged exhalation affects decision-making in the context of acute social stress. |
SOYOUNG Q PARK; | 2026-04-01 |
| 11 | A Phase 3 Multicenter, Open-label Study to Assess The Long-term Safety and Tolerability of KarXT in Adolescents (13 to 17 Years of Age) With Schizophrenia and KarXT+KarX-EC in Children and Adolescents (5 to 17 Years of Age) With Irritability Associated With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the long-term safety and tolerability of KarXT and KarX-EC for the treatment of Schizophrenia and autism-related irritability in adolescents, respectively |
KARUNA THERAPEUTICS INC A BRISTOL MYERS SQUIBB COMPANY | 2026-03-27 |
| 12 | Optical Imaging As A Diagnostic Tool for Monitoring Brain Function in X-linked Rare Disorders PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Fragile X syndrome (FXS, OMIM #300624) and Creatine Transporter Deficiency (CTD, #300352) are the two most common causes of X-linked intellectual disability. FXS and CTD affect hemizygous males and with highly variable severity heterozygous females. Both these neurodevelopmental disorders (NDDs) have a dramatic impact on the family quality of life and the health-care system. These disorders share common clinical traits, including intellectual disability, autistic-like features, behavioural and mood alterations and seizures. Brain anatomy appears largely normal, suggesting that functional deficits result from subtle changes in synaptic connectivity. Moreover, … |
AURORE CURIE; | 2026-04-01 |
| 13 | Telehealth Mindfulness-based Intervention for Adolescents With Autism Spectrum Disorder and Their Caregivers PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether a mindfulness-based intervention can reduce depression and anxiety in autistic adolescents. The main question this trial aims to answer is: Do adolescents who complete MINDful TIME show reductions in depression and anxiety compared to an active control group? Researchers will compare adolescents who complete MINDful TIME to adolescents who are instructed to use a mindfulness meditation mobile-app to see if changes in anxiety and depression differ between the two groups. Participants will either: * Attend weekly 90-minute MINDful TIME group meetings through Zoom with their parent or caregiver for a total of 8-weeks and use a mindfulness meditation app daily, or * Use a mindfulness meditation app daily for 8-weeks All participants will: * Attend virtual intake, baseline, and follow-up visits to complete data collection * Complete a weekly electronic meditation diary |
NICOLE MATTHEWS; | 2026-03-30 |
| 14 | Milieu Teaching-AV (MT-AV Pilot): A Pilot Study to Assess The Feasibility of An Adaptation of Milieu Teaching for Infant Siblings of Autistic Children That Encourages Looking to The Mouth Related Papers Related Patents Related Grants Related Experts Highlight: This project will look at whether a novel approach to language intervention that encourages looking to audiovisual speech cues for infants with autistic older siblings (Baby Sibs), who are highly likely be diagnosed with autism or developmental language disorder (DLD). This study will specifically look at (a) whether caregivers find this approach to be easy to implement in their homes, (b) whether they find this approach to be acceptable, and (c) whether caregivers use the taught strategies in interactions with their infants. |
JACOB I FELDMAN; | 2026-03-24 |
| 15 | A Complementary and Integrative Healthcare (CIH) Model for Children With Autism Spectrum Disorder-Related Symptoms: A Pilot Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To investigate the feasibility of implementing an online assessment battery in tandem with normal \& customary complementary \& integrative healthcare (CIH) provided to children with autism. The secondary aim is to assess the potential impacts of CIH on clinical outcomes. |
TYSON PEREZ; | 2026-03-20 |
| 16 | Adapting and Testing A Novel Method of Engagement in Research: Centering Autistic Perspectives in Behavioral Intervention Discussions PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The Centering Autistic Perspectives for Behavioral Interventions Discussions (CAPBID) PCORI Science of Engagement Award will examine different community engagement approaches for bringing together autistic people, Applied Behavioral Analysis (ABA) providers, … |
MATTHEW LERNER; | 2025-09-10 |
| 17 | Study of Pharmacological and Clinical Correlates of The Electroencephalographic Signal During Induction, Maintenance and Emergence Phases of General Anesthesia or Procedural Sedation in Adults and General Anesthesia in Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective, multicenter, non-interventional observational study investigates the correlates between electroencephalographic (EEG) signals and pharmacological/clinical parameters during general anesthesia and procedural sedation. The study will enroll 330 participants across three distinct populations at two AP-HP sites (Bichat-Claude Bernard Hospital and Louis Mourier Hospital): 1. Pediatric cohort (n=110): Children aged 1-17 years undergoing general anesthesia, … |
DAN LONGROIS; | 2026-03-10 |
| 18 | Randomized, Double-Blind, Placebo-Controlled Cross-Over Study to Evaluate The Effects of Cannabidiol on Neurobehavioral and Function Outcomes in Sanfilippo Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to test cannabidiol in Sanfilippo syndrome. The main questions it aims to answer are: 1) determine the safety of cannabidiol in Sanfilippo syndrome, and 2) explore the efficacy of cannabidiol in treating the neurobehavioral symptoms and functional outcomes of Sanfilippo syndrome. Each participant’s caregiver will be asked to complete surveys related to the participant’s behavior, mood, sleep, stooling, pain, and caregiver stress intermittently throughout the study. All participants will be enrolled into one of two cohorts based on enrollment order: 1. Sentinel Safety Cohort (first 5 participants) – … |
LYNDA E POLGREEN; | 2026-02-27 |
| 19 | Characterization of The Natural History of Microduplication Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: 7q11.23 duplication syndrome (7q duplication syndrome/7DUP) is caused by a microduplication of the 7q11.23 chromosomal region, encompassing 26-28 genes, including the GTF2I gene. This syndrome, often considered as a mirror phenotype of Williams-Beuren syndrome (WBS), is characterized by a wide range of neurodevelopmental impairments, including a neurodevelopmental disorder (NDD), autism spectrum disorders (ASD), selective mutism, mild dysmorphic features, and aortic dilation. Notably, one of the core clinical features of 7DUP is socialization impairment, which varies in severity across individuals. The GTF2I gene, identified as critical in the pathogenesis of both WBS and 7DUP, … |
HOSPICES CIVILS DE LYON | 2026-03-13 |
| 20 | A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted By PannaWire PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Atrial septal defect (ASD) is a common congenital heart disease, and percutaneous interventional therapy is the main and effective treatment. Traditional percutaneous closure procedures are performed under fluoroscopic guidance and require contrast agents. A retrospective analysis of over 20,000 adult patients with congenital heart disease revealed that even low-dose radiation exposure was significantly associated with an increased long-term risk of malignancy. Moreover, the use of contrast agents carries the risk of allergic reactions and kidney injury. Radiation and contrast agents not only pose iatrogenic harm to patients but also limit the use of interventional techniques in special populations, … |
PAN XIANGBIN; | 2026-03-17 |
| 21 | Research on Speech Development Trajectories and Predictive Models in Children With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Recent studies indicate that children with ASD have a significantly higher risk of co-occurring speech sound disorders than typically developing children. Early atypical speech development may be a critical yet overlooked bottleneck hindering their language improvement. Given the unique phonetic features of Mandarin, it is essential to investigate speech development in Mandarin-speaking children with ASD. This study aims to construct developmental trajectories and establish early identification and prognosis prediction models for this population. |
CHEN LI; | 2026-03-17 |
| 22 | Identification of Neural Markers of Aggression and Irritability and Their Capacity to Predict Treatment Response to CNS Stimulant Medication in Youth With ADHD PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Impulsive Aggression and chronic irritability (IACI) often occur together and are one of the most common reasons children present for behavioral health (BH) care. ADHD frequently associated with IACI as upwards of 50% of youth with ADHD manifest impairing IACI levels. IACI is the most common reason that children with ADHD are prescribed antipsychotics and admitted to inpatient BH units. Systematic dose optimization of CNS stimulants improves levels of IACI, reducing the need for these more intensive and burdensome treatments. However, response varies, with over half of children with ADHD showing meaningful improvement, … |
JAMES WAXMONSKY; | 2026-03-16 |
| 23 | Testing A Mobile App-Based Intervention to Improve Toothbrushing Skills and Habits in Children and Teens With Autism PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to test whether the autism-friendly app improves toothbrushing outcomes compared to a control app with only a digital mirror and countdown timer among children and teens (ages 8-17 years) with autism. The main questions it aims to answer are: 1. Will toothbrushing distribution, duration, … |
DONALD CHI; | 2026-03-03 |
| 24 | Impact and Effectiveness of Training Primary Care Clinicians to Diagnose Autism in Children 18-36 Months By Primary Care Clinicians: A Multisite Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is looking at time to diagnostic resolution for children ages 18-36 months with concern of ASD. The main purpose of this research study is to see if the time between when a child aged 18-36 months fails an autism screen or a clinician raises concern and is evaluated is shorter in the primary care practices where the clinicians have been trained to conduct diagnostic evaluations. The training includes use of the Childhood Autism Rating Scale-2, … |
CAROL WEITZMAN; | 2026-03-09 |
| 25 | Dense Cranial Electroacupuncture Stimulation Plus Body Acupuncture for Adolescents With Psychological Distress: A Randomized Controlled Trial With Observations on Salivary Oxytocin and Cortisol Changes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is an assessor-blinded, randomized, MAS-controlled trial. A total of 148 adolescents aged 15-22 years experiencing mild to moderate anxiety or depressive symptoms will be recruited. They will be randomly assigned to DCEAS+BA (n = 74) and MAS (n = 74) for 2 sessions per week for 8 weeks, followed by a 4-week post-treatment observation period. A post-intervention visit will be held at week 12. The primary outcome will be assessed using the Chinese version of the Beck Anxiety Inventory (BAI-C). The secondary outcomes include the Beck Depression Inventory II (C-BDI-II) for depression, … |
ZHANG ZHANG-JIN; | 2026-01-26 |
| 26 | Parent-Mediated Telehealth Intervention for Insomnia in Young Autistic Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will evaluate the efficacy of a structured parent-mediated behavioral intervention called Sleep Parent Treatment (SPT) for insomnia in autistic children ages 3 to 7 years 11 months, compared to another behavioral intervention called Sleep Parent Education (SPE). Eligible children will be randomly assigned to either the SPT or SPE intervention for 10 weeks. |
LAWRENCE SCAHILL; | 2026-02-27 |
| 27 | Effect of Oral Melatonin Versus Oral Midazolam As A Premedication in Children Undergoing Tonsillectomy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal. Melatonin is a hormone secreted by the pineal gland. Melatonin is different from benzodiazepines and their derivatives in that it exerts a promoting effect on sleep by amplifying day/night differences in alertness and sleep quality and displaying a modest sleep-inducing effect, quite mild as compared to that seen with benzodiazepines (Ahmad et al., … |
WAEL SAYED EL GHARABAWY; | 2026-01-13 |
| 28 | Characterization of Social Cognition Profiles in Children and Adolescents With Neurodevelopmental Disorders: A Clinical Study Using A Multidimensional Battery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In France, more than one in ten school-aged children suffers from a mental health disorder, and half of these disorders appear before the age of 14. Yet, only half of affected children receive appropriate support. At the cognitive level, it is now widely accepted by the scientific community that strong socio-cognitive skills protect against the emergence of certain disorders. Social cognition skills, crucial for development and social integration, are often underestimated in clinical neuropsychology, … |
DOROTHÉE LEUNEN; | 2026-02-27 |
| 29 | Efficacy of Xenon in Children With Autism Spectrum Disorder: A Multicenter, Randomized, Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the efficacy and safety of inhaled xenon for the treatment of children with autism spectrum disorder (ASD). The primary objective is to determine whether short-term inhalational xenon therapy can improve social functioning in children with ASD, as measured by changes in the Social Responsiveness Scale (SRS). Safety and tolerability of xenon inhalation in the pediatric population will also be assessed. In this randomized, placebo-controlled trial, … |
DAQING MA; | 2026-02-27 |
| 30 | A Pilot Investigation of The Competence in Romance and Understanding Sexual Health Curriculum PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether the CRUSH curriculum is possible (feasible), whether it fits the needs of the adults it is designed for (acceptable), … |
SUSAN FAJA; | 2026-02-12 |
| 31 | Heart Voice: Starry Journey – A Family-Centric and Acceptance and Commitment Therapy Based Digital Narrative Intervention, on Psychological Flexibility and Mental Health in Caregivers of Children With Autism Spectrum Disorder: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the effectiveness of the Heart Voice: Starry Journey program, a family-centric and Acceptance and Commitment Therapy (ACT)-based digital narrative intervention, in improving psychological flexibility and mental health among primary caregivers of children with Autism Spectrum Disorder (ASD). The main questions it aims to answer are: 1. Does the Heart Voice: Starry Journey intervention lead to a greater improvement in psychological flexibility among caregivers of children with ASD, … |
HANPING GAO; | 2026-01-06 |
| 32 | Impact of Non-Invasive Neuromodulation on Social Media Addiction PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether transcranial direct current stimulation (tDCS), a non-invasive brain stimulation, can reduce craving and problematic levels of social media/internet use in university students. The main questions it aims to answer are: * Does active tDCS reduce craving to use social media during the intervention period compared with sham stimulation and no stimulation? * Does active tDCS reduce internet/social media addiction severity (measured with the Internet Addiction Test, IAT) compared with sham stimulation and no stimulation, and are any effects still present at follow-up? Researchers will compare three groups-active tDCS, … |
EGAS MONIZ COOPERATIVA DE ENSINO SUPERIOR CRL | 2026-02-20 |
| 33 | Low Intensity Focused Ultrasound in Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates the safety and potential efficacy of personalized, image-guided low intensity focused ultrasound (LIFU) targeting the thalamus in individuals with Autism Spectrum Disorder (ASD). The study evaluates behavioral, neuroimaging, and electrophysiological outcomes following LIFU stimulation using a non-invasive device. |
KEVIN CAULFIELD; | 2026-02-24 |
| 34 | Effects of EAA Consumption on Recovery and Rehabilitation in Adult Spinal Deformity (ASD) Patients Undergoing Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This will be a randomized double-blind placebo controlled clinical trial to determine if supplementing with essential amino acids (EAAs) for two weeks prior to, and 3 months after corrective spinal surgery in adults with spinal deformity can stimulate greater muscle protein turnover and whole-body protein balance, and enhance recovery after surgery when compared to a calorie matched placebo. |
SHILOAH KVIATKOVSKY; | 2026-01-14 |
| 35 | Effects of Lactic Acid Bacteria in Patients With Attention-Deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to evaluate whether postbiotics supplementation can improve ADHD symptoms, such as mood and sleep, in children. Furthermore, salivary biochemical profiles will be analyzed and dietary habits will be recorded to further explore the effects and mechanisms of action of postbiotics. Research process: 80 subjects who meet the admission conditions will be recruited within three years after IRB approval. They will take the research capsules (postbiotics) in an open label design study and complete the 8-week intervention plus 4 weeks follow up trial period. |
I-CHING CHOU; | 2026-02-27 |
| 36 | Combined Effects of Sensorimotor Integration and Post-facilitation Stretch on Toe Walking and Foot Posture in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To determine the effects of sensory motor integration and post facilitation stretch on toe walking and sensory processing behaviors using Foot Posture Index and Sensory Profile respectively. |
MARIA KHALID; | 2026-03-30 |
| 37 | Efficacy of The Korean PEERS® for Preschoolers (PEERS®-PS-K) Social Skills Intervention: A Randomized Controlled Trial for Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the efficacy of the Korean version of the PEERS® for Preschoolers (PEERS®-PS-K), a parent-assisted social skills intervention for preschool-aged children with Autism Spectrum Disorder (ASD). Participants will be randomly assigned to either the intervention group, receiving the PEERS®-PS-K program, or a wait-list control group. The study focuses on improving social skills, such as making friends and interacting with peers, through structured lessons and parent coaching. |
JAE HYUN HAN; | 2026-04-01 |
| 38 | Non-Invasive Neuromodulation As A Strategy for Reducing Occupational Stress and Burnout in Higher Education PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate if transcranial direct current stimulation (tDCS) works to reduce occupational stress and burnout in university professors. The main questions it aims to answer are: Does tDCS reduce levels of occupational stress in university professors? Does tDCS reduce burnout levels in university professors? Researchers will compare active tDCS to a sham stimulation (a look-alike procedure that contains no active stimulation) and a control group to see if tDCS effectively reduces stress and burnout. Participants will: * Complete questionnaires assessing stress and burnout levels before the intervention * Complete follow-up assessments immediately after the intervention and 5 weeks later During intervention, participans of active tDCS and Sham gruops will: * Receive 10 sessions of tDCS over 4 weeks (excluding weekends), 20 minutes each |
EGAS MONIZ COOPERATIVA DE ENSINO SUPERIOR CRL | 2026-02-20 |
| 39 | Evaluation of Visual Perception Development in Autism: Duration of A Moment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study investigates the temporal dynamics of perception and attention in children with Autism Spectrum Disorder (ASD), focusing on two key phenomena: the Temporal Integration Window (TIW) and the attentional blink. Using eye-tracking, 3- and 5-year-old children with ASD (prototypical or not) will be compared to age-matched neurotypical peers. The investigators hypothesize that children with ASD exhibit shorter TIWs and attentional blinks, reflecting faster perceptual sampling and attentional processing. These characteristics may contribute to sensory hypersensitivity and difficulties in complex, unpredictable environments such as social situations. The protocol includes two experimental tasks. |
HÔPITAL LE VINATIER | 2026-02-05 |
| 40 | Evaluation of Long-term Efficacy of 4 to 6-month Course Antiviral Therapy for Neurodevelopmental Impairments Caused By Congenital Cytomegalovirus Infection: A Multicenter, Randomized, Controlled, Non-inferiority Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Title: Evaluation of Long-term Efficacy of 4-month versus 6-month Course Antiviral Therapy for Neurodevelopmental Impairment Caused by Congenital CMV Infection: A Multicenter, Randomized, Controlled, Non-inferiority Clinical Study 1\. Background and Rationale：Congenital cytomegalovirus (cCMV) infection is a leading cause of childhood neurodevelopmental disability and sensorineural hearing loss (SNHL). International guidelines, based on evidence from high-income countries, recommend a 6-month antiviral course for symptomatic infection. However, clinical practice in China lags significantly, … |
HU BOFEI; | 2026-03-04 |
| 41 | The Baby Duchenne Study: Characterizing Developmental and Clinical Outcomes in The First Three Years in Children With Duchenne Muscular Dystrophy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the BABY DUCHENNE study is to evaluate the natural history and characterize the early clinical outcomes in very young children (0-3 years) with Duchenne muscular dystrophy (DMD) identified by newborn screening programs. |
BO HOON LEE; | 2025-12-15 |
| 42 | Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With A Sublingual Formulation of Dexmedetomidine (BXCL501) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will examine the safety and efficacy of BXCL501 to reduce ASR symptoms and behavioral changes among patients presenting to the Emergency Department (ED) after Motor Vehicle Collision (MVC). Specifically, the investigators will perform the BXCL501 (BASIS) Trial, a double-blind placebo-controlled Randomized Controlled Trial (RCT) to determine if BXCL501 (dexmedetomidine hydrochloride sublingual film) initiated in the ED in the hours after MVC to high risk individuals, treats/reduces ASR/ASD symptoms (primary outcome), improves neurocognitive function, and prevents/reduces posttraumatic stress (PTS) symptoms (secondary outcomes) long term. 100 participants will be randomized, … |
SAMUEL MCLEAN; | 2026-02-11 |
| 43 | An Empowering Parent Training Intervention to Increase Physical Activity in Preschool Aged Children With Autism: A Randomized Control Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if WE PLAY for Parents can improve caregivers’ knowledge, attitudes, confidence, and skills promoting physical activity with their young child with autism. The main questions it aims to answer are: (1) Do participants who complete WE PLAY for Parents improve their knowledge, behavior intentions, perceived behavior control, self-efficacy, and parenting practices related to physical activity promotion with their child (Primary Hypotheses); and (2) Do participants view WE PLAY for Parents as acceptable, understandable, … |
JESSICA HOFFMAN; | 2026-02-27 |
| 44 | Presca : Prospective Study to Determine The Prevalence of Signs of Central Sensitization in Adults With ASD Without Intellectual Developmental Disorders PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Autism is a neurodevelopmental disorder (NDD) characterized by two key features: persistent deficits in communication and social interaction, and restricted, repetitive patterns of behavior, interests, and activities. Ninety-five percent of children aged 3 to 6 with autism spectrum disorder (ASD) have sensory peculiarities. In adulthood, this figure remains at 90%. This atypical sensory processing has been part of the DSM diagnostic criteria since 2013. Each sense can be affected by hypo- or hypersensitivity. In the continuum of this particular sensory processing, pain, which is defined as an unpleasant sensory and emotional experience, … |
ESTELLE ECR COTTE RAFFOUR; | 2026-03-27 |
| 45 | FLIGHT – Autism: An Open-Label, Prospective Study Evaluating The Feasibility and Effectiveness of An Education and Health Coaching Program Focused on Modifiable Lifestyle Factors for Parents of Children With Newly Diagnosed Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary purpose of this study is to evaluate the feasibility and effectiveness of an education and coaching program for parents of children with newly diagnosed autism that is focused on modifiable lifestyle factors and environmental modifications. A single-arm, open-label, prospective study will be conducted evaluating the feasibility and effectiveness of the 12-month education and health coaching intervention for parents as an adjuvant to comprehensive clinical care for 12 newly diagnosed children with autism. |
DOCUMENTING HOPE PROJECT | 2026-02-19 |
| 46 | Effects of Toe Spread Out Exercise With and Without Walking Surface Training on Navicular Drop and Jumping Performance in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Flatfoot is a common postural deformity in children, characterized by the collapse of the medial longitudinal arch, leading to abnormal foot posture, gait disturbances, and postural instability. Arch collapse in flatfoot is also due to navicular drop a condition where the navicular bone, located in the midfoot, shifts downward excessively when bearing weight. This excessive drop reflects poor structural support in the foot and is often linked to weakness in the intrinsic foot muscles. The intrinsic and extrinsic muscles of the foot, particularly the abductor hallucis (AbdH), … |
FAREEHA KAUSAR; | 2026-02-27 |
| 47 | Efficacy of A Virtual Reality-Mediated Intervention on Emotion Recognition and Understanding in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Autism Spectrum Disorders (ASD) are neurodevelopmental conditions characterized by difficulties in social interaction, communication, and in understanding one’s own and others’ mental and emotional states. In particular, skills related to the recognition, understanding, and regulation of emotions represent a significant area of vulnerability in children with high-functioning ASD, with important consequences for social and relational functioning. The present study aims to evaluate the effectiveness of an intervention protocol designed to enhance socio-emotional understanding, with a specific focus on the recognition of basic and complex emotions, the expansion of emotional vocabulary, the association between situations, thoughts, and emotions, … |
FLAVIA MARINO; | 2026-01-26 |
| 48 | Improvement of Sustained Attention Through Immersive Virtual Reality in Neurodivergent Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to determine whether playing a virtual reality (VR) game can help neurodivergent children pay attention for extended periods. The study includes children ages 9 to 18 who have autism, ADHD, learning differences, or movement coordination challenges. The program lasts for 6 weeks. During this period, children will play a VR game twice per week, with each session lasting 25 minutes. |
NEW YORK INSTITUTE OF TECHNOLOGY | 2026-01-14 |
| 49 | A Comparative Study of Anterior Insula Real-time FMRI Neurofeedback Training Based on Unidimensional Vs. Multidimensional Interoceptive Regulation Strategies PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to compare the neural and behavioral effects of real-time functional magnetic resonance imaging (fMRI) neurofeedback training using two different interoceptive strategies: a unidimensional heartbeat detection strategy and a multidimensional interoception strategy. Specifically, the study compares the efficacy of these two regulation strategies in regulating activity of the anterior insula, a key brain region involved in interoceptive and emotional processing. |
SHUXIA YAO; | 2026-02-18 |
| 50 | Pregnancy and Viral Infections: Impact on Pregnant Women and Their Children. French Prospective Cohort. PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The VIROPREG study is a French prospective multicenter cohort study that aims to assess the impact of viral infections and antiviral treatments received during pregnancy on maternal and child health. The study focuses on both chronic viral infections: human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV)\] and on arbovirus infections. This study aims at investigating the following research questions: * What is the rate of mother-to-child transmission for each virus? * What are the effects of maternal infection on (i) pregnancy outcomes, (ii) the mother’s physical and psychological health, and (iii) the fetus’ health and development, … |
ANRS EMERGING INFECTIOUS DISEASES | 2026-02-17 |
| 51 | The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavioral Changes in Children With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether intranasal sedation given before anesthesia can lower negative postoperative behavioral changes in children with autism spectrum disorder who undergo elective surgery. The study will compare two commonly used sedative medicines with a saline control. It will also examine the safety of these medicines and explore how brain electrical activity during recovery may relate to later behavior changes. The main questions this study aims to answer are: * Does intranasal dexmedetomidine given before anesthesia lower negative postoperative behavioral changes seven days after surgery in children with autism spectrum disorder? * Does intranasal esketamine given before anesthesia lower negative postoperative behavioral changes seven days after surgery in children with autism spectrum disorder? * Are there differences in postoperative agitation, pain, and sedation quality among the three groups? Researchers will compare dexmedetomidine, esketamine, and saline to see whether either medicine works better than saline in reducing postoperative behavior changes. Participants will: * Be randomly assigned to receive intranasal dexmedetomidine, intranasal esketamine, or intranasal saline about thirty minutes before anesthesia * Undergo their planned surgery with standard general anesthesia care ③ Be assessed for behavior changes at three, seven, and twenty-eight days after surgery ④ Have routine monitoring of recovery, pain, agitation, and safety outcomes during and after surgery |
SUN FEI; | 2026-01-07 |
| 52 | Autism Spectrum Disorder and Criminal Responsibility in The Italian Forensic Context – Multicenter Study for Italian Validation of The Forensic Autism Risk Assessment Scale PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a multicenter observational project designed to translate, culturally adapt, and validate the Italian version of the FARAS (FARAS-IT), a structured framework for assessing risk and protective factors specific to individuals with Autism Spectrum Disorder (ASD) involved in the Italian criminal justice system. Adult participants (≥18 years) with a diagnosis or well-founded clinical suspicion of ASD are consecutively enrolled over 12 months into three groups: offenders in forensic psychiatric settings under security measures, offenders considered criminally responsible and not under psychiatric care, … |
FELICE CARABELLESE; | 2026-01-28 |
| 53 | Involvement of The Autonomic Nervous System in Hepatocellular Carcinoma (HCC): A Pilot Psycho-behavioral and Neurophysiological Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Chronic liver diseases affect 1.5 billion people worldwide and can lead to cirrhosis and hepatocellular carcinoma (HCC), which ranks as the third leading cause of cancer-related mortality globally. Despite advances in the treatment of hepatitis B and C, metabolic diseases, and addiction, HCC incidence continues to rise. In France, between 2010 and 2015, the five-year survival rate for liver cancer (90% of which is HCC) was 18% for men and 19% for women. Treatment of HCC is based on the BCLC classification (Barcelona Clinic Liver Cancer), … |
HOSPICES CIVILS DE LYON | 2026-02-06 |
| 54 | Internalized Symptoms in Adolescents With Autism Spectrum Disorder (ASD) and Typically Developing Adolescents : Gaining Insight Into Coping Strategies and The Psychological Processes Involved PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: Adolescents with autism spectrum disorder (ASD) have more mental health problems than typically developping adolescents (without ASD). Coping strategies are a key concern for adolescents with ASD in managing depressive and anxiety symptoms. Currently, few studies have examined the coping strategies used by adolescents with ASD. The methodological considerations underscore the need for an assessment method tailored to adolescents with ASD. Finally, although current data are still limited, the results suggest that there may be differences between the coping strategies used by adolescents with ASD and typically developing adolescents, … |
NATHALIE NNG NADER-GROSBOIS; | 2026-01-29 |
| 55 | A Pharmaco-Imaging Trial of Mixed Amphetamine Salts for The Treatment of ADHD in Intellectually-intact Youth With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators are conducting a 10-week brain imaging and medication study. They are doing the research to study the response of Attention-Deficit/ Hyperactivity Disorder (ADHD) in youth with Autism Spectrum Disorder (ASD) on extended-release formulation of mixed amphetamine salts (MAS) (also know as Adderall XR). The investigators also want to find out if taking MAS has any effect on the brains of children and adolescents with ADHD and ASD. This study will help researchers better understand how the use of MAS to treat ADHD effects children and adolescents with ASD. The investigators will compare MAS to a placebo. The placebo will look exactly like the MAS capsules but will contain no MAS. During this study, participants may get a placebo instead of MAS. Placebos are used in research studies to see if the study results are due to the study drug or due to other reasons. Participants with ASD and ADHD will complete 4-weeks of treatment with the study medication or placebo. They will complete bi-weekly study visits virtually via a telemedicine platform with the study doctor and complete questionnaires. On alternating weeks, they will meet with a Massachusetts General Hospital (MGH) study team member to discuss medication adherence and potential side effects. Participants will have the option to attend all study visits in-person if participants prefer. They will also complete baseline and endpoint Magnetic Resonance (MR) scan visits at Massachusetts Institute of Technology (MIT). During the MR Scan visits, they will complete a series of tasks to measure inattention, impulsivity, reward sensitivity, decision-making, and working memory. Participants without ADHD or ASD will complete eligibility screening with MGH. If eligible, they will be invited to baseline and endpoint MR scan visits at MIT. During the MR Scan visits, they will complete a series of tasks to measure inattention, impulsivity, reward sensitivity, decision-making, and working memory. |
GAGAN JOSHI; | 2026-03-06 |
| 56 | Coaching and Leadership in Autism Support Settings PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Schools serve a large number of autistic children, yet face two critical gaps that stifle the delivery of evidence-based practices: 1) an intervention gap characterized by limited availability of evidence-based practices educators can use to address externalizing behaviors when they occur in the classroom; and 2) an implementation gap consisting of insufficient evidence-based practice fidelity and sustainment over time. To address these gaps, this project proposes a hybrid type 2 effectiveness-implementation trial that simultaneously tests: 1) the clinical effectiveness of an efficient, educator-delivered clinical intervention to reduce autistic children’s externalizing behaviors (Research Units in Behavioral Interventions in Educational Settings; RUBIES), … |
JILL LOCKE; | 2025-12-11 |
| 57 | Evaluation of Social Cognition: A New Screening Approach for Autism PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Social cognition refers to the mental processes involved in social interactions, including social perception, motivation, communication, emotion recognition, and theory of mind. Face perception plays a key role in children’s social development, but children with Autism Spectrum Disorder (ASD) tend to look less at social stimuli, especially faces, than typically developing (TD) peers. Eye-tracking studies highlight these visual exploration differences, linked to difficulties in joint attention, emotion recognition, and theory of mind, as well as in executive and memory functions. Standard diagnostic tests often require active participation and sufficient language, … |
CENTRE HOSPITALIER UNIVERSITAIRE AMIENS | 2026-02-06 |
| 58 | EXPLORATIONS CELLULAIRES – CELLULES PLURIPOTENTES INDUITES DES SUJETS PRESENTANT UN TSA, DE LEURS APPARENTES, ET DE TEMOINS PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and verbal and non-verbal communication (DSM-5, 2013), affecting approximately 2% of the general population. In 5 to 40% of cases, genetic factors are identified as the cause of these disorders, with prevalence depending on the technique used (exomes and/or SNP arrays) and the associated intellectual deficit. In the majority of cases, … |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE FRANCE | 2025-12-30 |
| 59 | Efficacy and Safety of Functional Neurogenesis Stimulation Therapy in Children With Autism Spectrum Disorder: A Multicenter, Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will test whether a noninvasive brain stimulation treatment called Functional Neurogenesis Stimulation (using the NeuroCytontron device) can safely improve core symptoms of Autism Spectrum Disorder (ASD) in children. The study will enroll boys and girls 3 to 12 years old who have ASD (DSM-5 level 1 – … |
LORENZO R MORALES MANCIAS; | 2025-12-16 |
| 60 | Effectiveness- Implementation Trial of The Function-Based Elopement Treatment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to test whether the Function-Based Elopement Treatment (FBET) can reduce elopement in children aged 4-12 with autism spectrum disorder (ASD), and to assess its feasibility in community-based Applied Behavior Analysis (ABA) clinics. Researchers will evaluate FBET in a single-arm open-label trial in one clinic, … |
MINDY SCHEITHAUER; | 2025-12-12 |
| 61 | Trial of An Online Spanish Pivotal Response Treatment Training in Autism Spectrum Disorder (PRT-OS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to understand if an online course in Spanish can help Spanish-speaking parents use Pivotal Response Treatment (PRT) to support language and social skills in young children with Autism Spectrum Disorder (ASD). This study aims to reach families who may have trouble accessing autism services due to language, location, … |
GRACE GENGOUX; | 2026-02-03 |
| 62 | Play Therapy With Gamified Biofeedback in Children With Autism Spectrum Disorder: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial tests whether combining regular play therapy with gamified biofeedback helps children with autism spectrum disorder better regulate their emotions and improve social skills, compared to play therapy alone. Sixty-eight children will be randomly assigned to 8 weekly 50-minute sessions: one group receives play therapy only, while the other receives play therapy plus real-time biofeedback using a comfortable armband that turns heart-rate calming into fun game rewards. Parents and teachers will complete short questionnaires before and after the study. All activities are playful, safe, and designed to feel natural and enjoyable for children with autism. |
LUIZ ALEXANDRE VIANA MAGNO; | 2026-02-05 |
| 63 | A Randomized Controlled Trial of Executive Function Intervention for Children With Autism Spectrum Disorder(ASD) Combining Digital Application and Parent Coaching PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this randomized controlled study is to develop and evaluate a digital cognitive control intervention that integrates a digital application-based child training program with an online parent coaching program for early school-aged children aged 5-8 with autism spectrum disorder (ASD) and their caregivers in South Korea. This intervention is designed to enhance clinical applicability, sustainability, and generalization to daily life of executive skills through active parental involvement. This study has three primary aims: (1) to examine the feasibility, acceptability, and implementation fidelity of the integrated child-parent digital intervention, … |
SO HYUN KIM; | 2026-01-30 |
| 64 | Study Protocol for A Randomized Controlled of Fecal Microbiota Transplantation Via Different Routes in Children With Moderate-to-Severe Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single-center, randomized, double-dummy, triple-blind, placebo-controlled, three-arm parallel-group superiority trial. The study aims to compare the efficacy and safety of Fecal Microbiota Transplantation (FMT) administered via two different invasive routes-nasojejunal tube (NJT) and colonoscopy-versus a placebo control in children aged 3-16 years with moderate-to-severe Autism Spectrum Disorder (ASD). A total of 75 participants will be randomized in a 1:1:1 ratio to receive either active FMT via NJT with sham colonoscopy, active FMT via colonoscopy with sham NJT, … |
DONGLING DAI; | 2026-02-05 |
| 65 | Follow-up of Current Psychotic Symptoms, Level of Function and Psychiatric Co-morbidity Among Adolescents With Autism, 10 Years After Identification of Psychotic Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose: To describe level of function, psychotic and psychiatric symptoms in a 10-year follow up of individuals with autism and psychotic symptoms. Method: A case-control study based on a cohort of 48 teenagers with autism established 2013. In the original study, 22 participant reported psychotic symptom in self-evaluation questionnaires design for early detection. We aim to recruit these individuals and controls from the same cohort without psychotic symptoms. Data will be collected from self-rating scales, clinical evaluation including semi-structured interviews and healthcare journals. The study is primarily descriptive, with group comparison by non-parametric method. |
SVERRE WIKSTRÖM; | 2026-02-23 |
| 66 | Randomized Controlled Trial of An Online Pivotal Response Treatment Training in Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a research study that will assess the effects of a Pivotal Response Treatment Online Training Course (PRT-O) for training parents of children with Autism Spectrum Disorder (ASD). The study will specifically investigate whether participants can learn to deliver PRT effectively following participation in the Online training. |
GRACE GENGOUX; | 2026-02-03 |
| 67 | Self-inspired & Tailored Autism Movement With Phystic App PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if watching instructions for daily exercises with three different contents (the patients themselves, other children, or children dressed as rabbits in addition to their physiotherapist, could increase physical activity among children with autism. The main questions it aims to answer are: Are children with autism motivated to engage in daily exercise by seeing themselves in a mobile application? Researchers will compare instructions with the children themselves with instructions containing other children and children in rabbit suits. Parents and their children will use the mobile application once daily for 8 weeks, … |
OSKAR LUNDGREN; | 2026-03-20 |
| 68 | Randomized Controlled Trial of Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if propranolol can help reduce challenging behaviors associated with Autism Spectrum Disorder, including aggression, self-injury, and severe disruptive behaviors. Participants will be randomly assigned to receive either propranolol or a placebo (a look-alike substance that contains no drug) daily for 12 weeks. After the 12 weeks, all participants will have the opportunity to receive propranolol for an additional 12 weeks. |
JEREMY VEENSTRA-VANDERWEELE; | 2026-03-30 |
| 69 | The Effect of The Social Stories Technique on Anesthesia Compliance in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Children with Autism Spectrum Disorder (ASD) frequently experience heightened anxiety and reduced cooperation during the perioperative period, which can complicate anesthesia induction and negatively affect procedural safety and efficiency. Non-pharmacological behavioral preparation methods that enhance predictability and understanding of medical procedures may improve anesthesia-related cooperation in this vulnerable population. The Social Stories Technique is a structured, … |
ELIF SULE OZDEMIR; | 2026-02-02 |
| 70 | A Comparative Study of Continuous Vs. Intermittent Real-time FMRI Neurofeedback in Regulating Anterior Insula Activity PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main aim of this study is to compare the efficacy of intermittent with continuous real-time functional magnetic resonance imaging (fMRI) neurofeedback on anterior insula regulation and associated behavioral changes. |
SHUXIA YAO; | 2026-02-05 |
| 71 | Randomised Controlled Trial of A Cognitive, Emotional and Social Stimulation Programme for Socioeconomically Disadvantaged Children PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Latin America and the Caribbean exhibit high rates of poverty and social exclusion, where a significant portion of the population faces challenges in meeting basic needs. This socioeconomic vulnerability exacerbates environmental violence and its associated consequences. Recognizing that contexts of poverty and social exclusion can adversely impact children’s cognitive and emotional development, this research protocol aims to address these challenges. It proposes a cognitive and emotional stimulation program, complemented by an intervention targeting teachers and caregivers, grounded in neuroeducational principles. The overarching goal is to enhance children’s cognitive and academic performance, … |
JOAN DEUS YELA; | 2025-12-17 |
| 72 | A Randomized Controlled Trial of Multimodal Rehabilitation Versus Standard Care on Adjacent Segment Degeneration in Frail Elderly Patients Undergoing Short-Segment Lumbar Fusion PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, randomized controlled trial aimed at evaluating whether a structured multimodal rehabilitation program can delay or reduce the occurrence of adjacent segment degeneration (ASDeg) in frail elderly patients after short-segment lumbar fusion surgery. |
XUANWU HOSPITAL BEIJING | 2026-02-17 |
| 73 | The Modulatory Effects of Oxytocin on Emotional Processing and Its Acting Routes PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main goal of this study is to investigate the modulatory effects of intranasally administrated oxytocin on the processing of emotional stimuli and its acting routes. |
SHUXIA YAO; | 2026-02-23 |
| 74 | Development and Evaluation of A School-Based Occupational Therapy Program Focused on Sensory Processing and Activities of Daily Living: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to develop and evaluate a school-based occupational therapy program focused on sensory processing and activities of daily living for children with Autism Spectrum Disorder and Intellectual Disability. Sensory processing difficulties often affect school participation, behavior regulation, and independence in daily tasks. Although occupational therapy interventions have shown benefits in clinical settings, … |
FEYZA ŞENGÜL; | 2026-01-16 |
| 75 | Flexible Fibrescope Versus Video Laryngoscope for Nasotracheal Intubation – A Randomised Comparison PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Patients having surgery under general anaesthesia require insertion of a breathing tube to keep the airway open. The technique of inserting a breathing tube through the nose into the trachea (airway) is known as nasotracheal intubation. This is the ideal airway for surgical procedures performed inside the mouth such as complex teeth extractions and operations on the jaw. Traditionally, the breathing tube is initially inserted blindly into the nasal cavity, … |
UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST | 2026-01-20 |
| 76 | Hamburg Emotion Awareness and Regulation Group Training for Autistic Adolescents (HEART) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study focuses on a group training program called HEART aimed at helping adolescents with Autism Spectrum Disorder improve emotional regulation. It will use a pilot trial to evaluate the program’s feasibility and effectiveness. The findings aim to advance scientific understanding and support the development of effective, evidence-based interventions to strengthen psychosocial support for autistic adolescents. |
JOHANNES BOETTCHER; | 2025-09-26 |
| 77 | Social Groups for Autistic Young Adults (SDARI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a clinical trial that will test whether a group program called SDARI (Socio-dramatic Affective Relational Intervention) can help autistic young adults between the ages of 18 and 30 feel more connected to others and improve their social relationships. The study will try to answer: Can SDARI be used successfully with autistic adults? Does SDARI help people feel more connected, supported, and mentally well? There are two groups in the study. One group will participate in the SDARI program, … |
MATTHEW LERNER; | 2025-10-31 |
| 78 | Movement Sonification As An Add-on to Immediate Post-event Psychotherapeutic Intervention in The Management of Acute Stress Disorder: A Feasibility and Acceptability Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Natural disasters, conflicts, persecution, population displacement, often traumatic migration experiences, and terrorist attacks are all factors that currently expose a significant proportion of the world’s population to potentially traumatic events (PTEs). When a person is exposed to a PTE, symptoms of acute stress disorder (ASD) may occur in the immediate aftermath of the PTB, i.e., within the month following the event. These symptoms are dominated by dissociation, which includes depersonalization, i.e., the feeling of being disconnected from one’s body. Managing these symptoms can prevent the subsequent onset of post-traumatic stress disorder (PTSD), … |
NICOLAS BOSC; | 2025-12-29 |
| 79 | Effects of The Sequential Oral Sensory Feeding Approach and Occupational Performance Coaching in Children With Avoidant/Restrictive Food Intake Disorder (ARFID): A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to investigate the effects of the SOS approach alone, or the SOS approach plus the OPC intervention, on children’s feeding problems and feeding behaviors, as well as parents’ feeding attitudes and mealtime behaviors in children diagnosed with ARFID. This randomized, single-blind, … |
EZGINUR GÜNDOĞMUŞ; | 2026-02-04 |
| 80 | The Effect of Dual-tasking Program on Cognitive and Physical Functions and Independence in Activities of Daily Living in Children With Duchenne Muscular Dystrophy: A Single-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and frequent developmental, cognitive and behavioral impairments, occurring in one in 5000 live births of boys. DMD is caused by a deficiency of the protein dystrophin, which maintains the structure and functionality of muscle cells. The absence of dystrophin leads to the weakening and eventual death of muscle cells, resulting in reduced muscle strength and impaired motor function. In early childhood, children with DMD may experience delays in basic motor skills such as walking and standing. Later in life, … |
BAŞAK ÇAĞLA ARSLAN; | 2026-01-27 |
| 81 | Understanding and Treating Severe and Resistant Pathological Aggression: Using Deep Brain Stimulation to Treat Resistant Aggression Related Papers Related Patents Related Grants Related Experts Highlight: Physical aggression can be defined as the use of force with the intention of causing physical injury, psychological damage or death. Pathological aggression may be associated with various psychiatric disorders. This symptom can often be improved by prescribing medication, implementing psychoeducational strategies or even electroconvulsive therapy. However, some patients exhibit such severe pathological aggression that they must be institutionalised because they pose a danger to themselves or others. These patients are then hospitalised in a unit for difficult patients (UMD) for enhanced therapeutic care. Despite this maximum level of care, the pathological aggression of a minority of patients persists, … |
UNIVERSITY HOSPITAL ROUEN | 2026-01-02 |
| 82 | Adia MED of Winter Park LLC Autism Spectrum Disorder Research Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This 24-month study is testing whether adding AdiaVita, an umbilical cord blood-derived stem cell and exosome product, to glutathione therapy helps improve autism symptoms in children ages 3-12 more than glutathione alone. Children will be randomly placed into one of two groups for the first three months: one group receives glutathione only, and the other receives glutathione plus monthly intravenous AdiaVita infusions. Both groups also use topical glutathione cream twice daily at home. Autism symptoms will be tracked over two years using the Autism Treatment Evaluation Checklist (ATEC) filled out by parents and by therapists or teachers. Safety, side effects, … |
ADIA MED OF WINTER PARK | 2026-02-06 |
| 83 | Digitizing and Automating The Diagnostic Psychiatric Assessment Process PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an observational study that will be responsible for the Spanish translation and cross-cultural adaptation, and validation of the Electronic Semi-Structured Psychiatric Interview for Children and Adolescents (EPSI-C), to examine, classify, prioritize, and diagnose patients. |
IRENE LOPEZ ARMENTEROS; | 2026-03-12 |
| 84 | Sensory Toys for Anxiety Reduction – Can Fidget Toys Improve Stress and Help Children to Cope Before Surgery (STARFISH) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Anxiety associated with medical procedures is common, with 40-80% of children experiencing significant symptoms and postoperative consequences, including distress and delirium, increased intensity/duration of pain, prolonged hospital stays, behavioural/sleep disturbance and avoidance of medical encounters, which often remain into adulthood. Extensive consumer research has shown that a key priority for Australian consumers of all ages in relation to paediatric hospital care is addressing the fear and anxiety in children throughout the hospital experience (second only to anaesthesia safety for adults and third following anaesthesia safety and pain management for children). The STARFISH trial was driven by our consumer partners, … |
TELETHON KIDS INSTITUTE | 2026-03-24 |
| 85 | Diagnosis Disclosure Support Intervention Program for Caregivers of Children With ASD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this randomized controlled pilot study is to develop and evaluate an online diagnosis disclosure support intervention for caregivers of 7- to 12-year-old children with autism spectrum disorder (ASD) in South Korea. This intervention is designed to support caregivers who are contemplating, preparing for, or carrying out disclosure of their child’s ASD diagnosis to the child. This study has three primary aims: (1) to evaluate the acceptability and feasibility of the intervention; (2) to examine clinically meaningful effects of the intervention on caregivers’ psychological well-being and psychosocial adjustment (e.g., emotion regulation, loneliness/social isolation, and adaptation to life transitions), … |
SO HYUN KIM; | 2026-01-21 |
| 86 | Quantitative Assessment of Static Balance in Children With Autism Spectrum Disorder Using VRRS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Children with autism spectrum disorder (ASD) often exhibit postural and balance difficulties, which can impact daily functioning and motor development. Quantitative assessment using Virtual Reality Rehabilitation System (VRRS) provides precise measurements to better understand these deficits and their potential relationship with cognitive functioning. This observational trial aims to evaluate static balance in children with ASD aged 6-10 years. A total of 50 participants were enrolled, with 10 children in each age group. Static balance was assessed using the VRRS and a specific balance task, measuring 13 quantitative parameters including Mean Distance Centre of Pressure (MD\_COP), … |
FLAVIA MARINO; | 2026-02-11 |
| 87 | An Examination of The Performance of QbMobile in Differential Diagnosis Associated With ADHD Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate QbMobile’s ability to collect objective data to identify specific symptom profiles in differential diagnoses (ASD, MDD, Bipolar Disorder and Anxiety Disorder) that are common with ADHD. |
QBTECH AB | 2026-01-09 |
| 88 | 8-Week Double-Blind, Randomized Controlled Study of N-Acetylcysteine and Neuroimaging in Children Ages 6-12 With Emotional Dysregulation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a double-blind randomized controlled study. The study will last up to 16 weeks from the initial phone screen (it could take up to eight weeks to schedule and complete the initial screening process and schedule the 2 MRI visits). Once subjects have completed the screening process, they will begin the 8-week trial phase. Subjects will be assessed weekly throughout the study for efficacy and tolerability. The investigators plan to recruit 80 participants with emotional dysregulation (ED) in the treatment arm. In addition, the investigators will aim to recruit 40age-, sex-, and parental-education matched participants without emotional dysregulation, … |
JANET WOZNIAK; | 2026-01-07 |
| 89 | CardioLogical Interventions and Acute StrOke Treatment STudy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to investigate characteristics and prognosis of ischemic stroke cases following cardiological interventions, focusing on the effectiveness and safety of acute ischemic stroke treatments. |
SIMONA SACCO; | 2026-01-07 |
| 90 | Management of Catatonic Features in Adolescents With Profound Autism: A Prospective Uncontrolled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if benzodiazepines and ECT can treat Catatonic features in Adolescents with Autistic spectrum disorder, it will also learn about Safety and efficacy of benzodiazepines and ECT. the main questions it aim to answer is if adolescents with profound Autism presenting with catatonic features will show significant improvement on treatment with either benzodiazepines or ECT with no major side effects. it is an open label pilot study whose participants diagnosed with profound autism presenting with catatonia will receive loading midazolam then maintenance clonazepam daily / ECT sets will be followed up every 2 weeks in 1st month then once / month for next 2 months, observation of symptom improvement will be tracked. Clinical outcomes will be assessed using the Pediatric Catatonia Rating Scale as the primary outcome measure and the Aberrant Behavior Checklist as a secondary outcome measure. Participants will be followed for three months to evaluate treatment response and safety. |
TOKA KHALED TALAAT; | 2026-03-27 |
| 91 | Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM : Double Blind Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This double-blind, randomized, sham-controlled clinical trial will evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on children and adolescents with attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and matched healthy controls. Participants aged 6-19 years will be assigned to active or sham rTMS protocols targeting the dorsolateral prefrontal cortex over 3 weeks, with assessment of changes in disorder-specific symptoms and cortical excitability. The study aims to determine the safety, feasibility, and preliminary efficacy of rTMS as a non-invasive neuromodulation approach in pediatric neurodevelopmental disorders. |
AMAAL EMAD KHAIRY; | 2026-01-02 |
| 92 | Effectiveness of A Person-Centered Lifestyle Intervention in Mothers of Children With Autism Spectrum Disorder: A Randomized Controlled Trial With 6-Month Follow-Up PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Mothers of children with autism spectrum disorder (ASD) experience substantial physical, emotional, and social strain due to the demands of continuous caregiving. These responsibilities often limit opportunities for health-promoting behaviors and contribute to elevated stress, fatigue, sleep disturbances, and reduced wellbeing. This study aims to evaluate an intervention designed to support the health and wellbeing of mothers who serve as primary caregivers of children with ASD. The intervention focuses on enhancing stress-management skills, improving participation in meaningful daily activities, … |
RUYA GUL TEMEL; | 2025-12-30 |
| 93 | Italian Adaptation and Validation of The In-person UCLA-PEERS® Model for Adolescents With Autistic Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Autism Spectrum Disorder (ASD) falls under the category of high complexity disorders which, in most cases, accompany individuals throughout their entire life with significant impacts and costs for individuals, their families, and society at large. Adolescence is a time of increasing challenge for teenagers with ASD and their families, as it is a time to lay the foundations for the transition to adulthood but at the same time, … |
ANTONIO NARZISI; | 2025-10-03 |
| 94 | MENU: A Novel Family-Driven Approach to Support Families Awaiting Autism Diagnostic Evaluation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The overarching goal of this project is to reduce autism-related health disparities. The investigators will develop and pilot MENU, a culturally responsive and caregiver-driven intervention specifically designed to support underserved families of young autistic children during the diagnostic wait period. MENU will equip underserved caregivers with flexible, evidence-based strategies to improve parent mental health, child social communication, and challenging behaviors. The intervention consists of modular content drawn from three well-established practices targeting core characteristics of autism: Acceptance and Commitment Therapy for caregiver mental health and well-being, Enhanced Milieu Teaching for child social communication, … |
JAMES D LEE; | 2026-01-06 |
| 95 | Longitudinal Assessment of Early Premature Infant Skills for Audiovisual Speech Perception PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: From birth, babies perceive speech face to face with their interlocutors in audiovisual situations (AV): in addition to hearing them (auditory speech), they will also, in most cases, be able to observe their speaking faces (ex: mouth movements, lips, tongue etc.) . However, … |
MARIE DR CHEVALLIER; | 2025-11-24 |
| 96 | Approche Rythmique Et Auditive Chez Les Enfants Avec Troubles Du Spectre De L’Autisme (TSA) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to assess the effectiveness of a rhythmic auditory training program in improving language skills in children with Autism Spectrum Disorder (ASD) who have a language acquisition disorder. The program focuses on training children to reproduce the syllable rhythms of speech, and the study will evaluate the children’s language skills before and after participating in the program. |
INSTITUT PASTEUR | 2025-12-24 |
| 97 | Fecal Microbiota Transplantation in Children With Autism Spectrum Disorder and Gastrointestinal Symptoms: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the study is to evaluate the effectiveness and safety of fecal microbiota transplantation (FMT) in reducing gastrointestinal (GI) and behavioral symptoms in children with autism spectrum disorder (ASD). Children with ASD often experience GI problems such as constipation, diarrhea, and abdominal pain. These symptoms can negatively affect their daily life and behavior. Recent research suggests that the gut microbiota-the community of bacteria and other microorganisms living in the intestines-plays an important role in digestion, immunity, … |
N.MED. ANNA LIBER; | 2026-01-27 |
| 98 | Better Social, Emotional Communication, Healthy Relationship and ASD Accommodation Skills: Emotional Intelligence (EQ) Training for Autistic People and ASD Accommodation Training for People Who Care PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Subjects are enrolled in pairs. Pairs consist of an autistic adult age 18-36 and a non-autistic learning partner who has a relationship with the autistic adult, such as a parent. The autistic adult in each pair receives the first stage of Kairon’s online leadership training consisting of emotional literacy and healthy relationship topics. The learning partner in each pair receives Kairon’s autism accommodation training while encouraging and providing feedback to their paired autistic adult. After training, both people in each pair evaluate the trainings’ impacts on themselves and on their partner. Specifically, … |
KAIRON CONNECT PBC | 2026-01-02 |
| 99 | Reducing Appointment NoShow Through Targeted Pre-appointment Messaging PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: There are four goals of this project: (1) To examine the impact of different appointment reminder messages on appointment attendance; (2) to determine the added benefit of a patient navigator reaching out in advance of appointments to families at elevated risk of missing their appointment, and determine the most common barriers families face in appointment attendance; (3) to evaluate which patients are at highest risk of missing their appointment, and to determine the effectiveness of the intervention trial across different patient risk levels; and (4) to examine if the missing appointment interventions increase the socioeconomic diversity patients. |
LUTHER G KALB; | 2026-03-18 |
| 100 | A Study on The Differences in N-CAD Concentration and Brain Function Between Children With Autism Spectrum Disorder and Typically Developing Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The incidence of autism spectrum disorders is increasing, about 1 / 36. Neural cadherin (NCAD) is closely related to synaptic structure and function. The cdh2 gene encoding NCAD has been shown to be associated with a variety of neurodevelopmental diseases and is one of the six risk genes for ASD. Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technology that uses the principle of near-infrared spectroscopy to detect the functional activation of human cortex. The application of fNIRS to explore the neural mechanism of children with ASD has developed rapidly. It has the advantages of non-invasive, portable, … |
CHEN LI; | 2026-02-10 |
| 101 | CARE-BI (Comfort and Analgesia for Removal of Brachytherapy Implants): A Pilot Study to Improve Patient Comfort and Reduce Psychological Distress During Intracavitary Applicator Removal PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this research study is to learn about the rate of posttraumatic stress disorder (PTSD) experienced by women after undergoing gynecologic brachytherapy. |
ANN H KLOPP; | 2026-01-13 |
| 102 | Randomized Control Trial (RCT) of Online Learning Module to Advance Research Related to People With Disabilities (D2/R3) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will measure the effects of a brief one-time eLearning intervention on researcher Knowledge, Attitudes, and Perceptions (KAP) of including people with disabilities (PWDs) in biomedical \& behavioral research. Researchers will be recruited from across the Einstein/Montefiore network, and other medical centers with a focus on CTSAs. |
KAREN BONUCK; | 2026-04-03 |
| 103 | Development and Preliminary Evaluation of A New Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to develop a new internet-delivered cognitive behavioral therapy (ICBT) intervention for youths with anxiety disorders based on the best current knowledge about effective cognitive behavioral therapy for the target group, refine the intervention in collaboration with patient and public representatives, and conduct a preliminary evaluation of the treatment effects in an open clinical trial. The primary objective of the study is: 1\. To evaluate the preliminary efficacy of a newly developed ICBT intervention for children and adolescents with anxiety disorders in reducing anxiety severity, … |
PER ANDRÉN; | 2026-02-20 |
| 104 | Feasibility of Wireless Continuous Vital Sign Monitoring and Impact on Patients Undergoing Adult Spinal Surgery in A General Ward PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this feasibility study is to explore the use of wireless continuous vital sign monitoring in an orthopaedic setting among orthopaedic nurses and patients undergoing adult spinal deformity surgery. In addition to the standard care National Early Warning Score the participants in this study will be monitored by CPC12S a wearable sensor that is worn on the chest using electrodes measuring electrocardiography single lead (ECG), Heart rate, respiratory rate, SpO2, … |
CAMILLA HEDEGAARD LARSEN; | 2026-01-08 |
| 105 | An Open-label Study Evaluating MM402 in Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A Phase 2A Trial of MM402 Open-Label Study in Adults with Autism Spectrum Disorder |
DEFINIUM THERAPEUTICS | 2026-02-09 |
| 106 | Early Intervention After Traumatic Exposure in Children and Adolescents: A Randomized Controlled Trial of The Effectiveness of Child and Family Traumatic Stress Intervention (CFTSI) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this interventional research is to evaluate the effectiveness of CFTSI in reducing post-traumatic symptoms measured using the CPC, child version, at the end of CFTSI treatment in children and adolescents aged between 7 and 17 years, exposed to an ET in the last 3 months. The main question(s) it aims to answer \[is/are\]: * CFTSI reduces posttraumatic Child Posttraumatic Stress Checklist (CPC) scores in children exposed to ET, both immediatly after completion of the CFTSI and at 3 months after completion. * CFTSI reduces post-traumatic scores in parents on the PTSD Checklist for DSM5 (PCL), … |
UNIVERSITY HOSPITAL MONTPELLIER | 2025-10-03 |
| 107 | Parent Training for Autistic Toddlers: Development and Preliminary Testing PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Latinx and Rural-living children with diagnosed or suspected autism have especially long wait times for diagnoses and intervention, up to a year or even more. This delayed access to intervention is likely to prevent children from reaching their full potential in skills and adaptive functioning. A comprehensive, online mobile device-based, free intervention that can be used by parents while on these wait lists may optimize their child’s development. The investigators have developed such a program, the Online Parent Training in Early Intervention (OPT-In-Early) program. It teaches parents the fundamental principles of both applied behavior analysis and naturalistic interventions, … |
KATHARINE ZUCKERMAN; | 2025-04-03 |
| 108 | Non-invasive Auricular Fiber Vagus Nerve Stimulation (afVNS) for Treatment of Autism Spectrum Disorder: An Open-Label Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Non-invasive vagus nerve stimulation for the symptomatic improvements in Autism Spectrum Disorder |
DANIEL KO; | 2026-01-08 |
| 109 | Evaluation of The Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Since early-onset preeclampsia (EOPE) is commonly associated with inadequate placentation, placental insufficiency, chronic fetal hypoxia, oxidative stress, and heightened inflammation, these pathological processes may adversely affect hippocampal neuronal development and maturation of axonal pathways such as the fornix. These mechanisms support our hypothesis that fetal fornix and hippocampus dimensions may be reduced in pregnancies complicated by EOPE, forming the scientific basis of our study. Previous research has suggested a potential link between preeclampsia (PE) and altered neurocognitive development. However, no studies to date have specifically evaluated the relationship between EOPE and fetal fornix or hippocampus dimensions. Therefore, … |
SEYIT AHMET EROL; | 2025-12-23 |
| 110 | Effects of Adapted Aquatic Exercise on Behavioral Outcomes, Flexibility, and Handgrip Strength in Male Children With Autism Spectrum Disorder: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized clinical trial studied whether an adapted aquatic exercise program could improve behavior and physical abilities in children with autism spectrum disorder (ASD). Thirty-five boys aged 6 to 12 years with mild ASD participated in the study. Participants were randomly assigned to either an aquatic exercise group or a control group. The aquatic exercise group took part in a structured, individualized swimming and water-based exercise program twice per week for 16 weeks, while the control group continued their regular academic education without additional exercise. The program focused on water safety, breathing control, … |
MONIRA ALDHAHI; | 2026-03-19 |
| 111 | Feasibility Study of Addressing Anxiety in Children With ASD and Intellectual Disability Through The Facing Your Fears Program PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Anxiety can be a debilitating and common concomitant diagnosis in autism spectrum disorders (ASD). Dependent on age and subtype of anxiety, the prevalence of anxiety in individuals with autism ranges between 1.7-84%. Meanwhile, the prevalence rate of intellectual disability (ID) in individuals with ASD ranges between 50-80% based on previous studies. There is an even greater risk of anxiety, ranging between 13.6- 43%, in individuals with ASD and ID. Despite the high prevalence of anxiety within this population, … |
JANYS LIM; | 2025-11-24 |
| 112 | An Open-Label Phase I Clinical Trial of Vancomycin Followed By Familial Fecal Microbiota Transplant in Adult Subjects With Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label clinical trial to evaluate the benefits of familial fecal microbiota transplant following a 6-week treatment with Vancomycin in adult subjects with ASD for treatment of social deficits and language delays. |
SABINE HAZAN; | 2025-09-23 |
| 113 | Prospective Clinical Study on Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for The Treatment of Childhood Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical study aims to evaluate whether a nasal spray containing exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EXOs) can safely and effectively improve core symptoms in children aged 3-7 years with autism spectrum disorder (ASD). It is a 24-week, randomized, controlled, open-label trial. Forty pediatric patients with ASD will be randomly assigned at a 1:1 ratio to two groups: an active exosome nasal spray treatment group and a no-intervention control group. The treatment group will receive the nasal spray every other day, … |
DONGFANG PEOPLE’S HOSPITAL | 2025-11-24 |
| 114 | Promoting Emotional and Autonomic Control Through Guided Breathing Exercises for Emerging Adults With Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study examines the impact of guided breathing exercises on stress and heart rate variability (HRV) in autistic young adults. It explores how daily movement behavior (sleep, physical activity and sedentary behavior) influences HRV and to what extent two guided breathing exercises can affect HRV. Additionally, the study investigates how participants perceive the exercises in terms of usability and usefulness. |
TINE VAN DAMME; | 2025-11-20 |
| 115 | CONEXUS: Prospective Study of The Feasibility of Brain Connectivity Imaging By Functional Ultrasound Imaging (fUS) in Newborn Infant PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Neurodevelopmental disorders (NDD) affect how the brain develops and can lead to lifelong difficulties with movement, learning, behavior, and thinking. Every year, around one million newborns in Europe are affected by these conditions. Some babies are at higher risk of NDD due to factors such as being born extremely premature, having poor growth in the womb, experiencing a lack of oxygen at birth, or having a family history of severe NDD. However, … |
VALERIE BIRAN; | 2025-12-18 |
| 116 | Glutamate Changes As A New Neurocognitive Marker in Psychosis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The project aims to explore changes in brain chemistry in individuals who have recently experienced psychosis. Recent research suggests that chemicals in the brain, specifically one called glutamate, may behave differently in people who have experienced psychosis compared to those who have not. It is also known that some individuals with psychosis can find tasks involving memory and attention more challenging. This study aims at understanding how brain chemistry is linked to memory and attention, … |
CLAUDIA DANIELMEIER; | 2025-11-24 |
| 117 | Investigation Into The Gut Microbiota-Immune-Inflammatory Interaction Network and Its Mechanisms in Patients With Ischemic Stroke PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: 1. Stroke stands as one of the leading causes of death and long-term disability worldwide, imposing a substantial socioeconomic burden. Annual new stroke cases are estimated between 9.5 million and 10.6 million. Stroke survivors commonly face challenges of poor long-term functional outcomes and compromised immunity, which not only drive quality-of-life deterioration but also fuel the persistent escalation of socioeconomic burdens. However, current clinical treatments for stroke prognosis improvement remain limited. In recent years, with the emergence of the microbiota-gut-brain axis concept and advancing research, the role of gut microbiota in stroke onset, progression, … |
YONGTAO GAO; | 2025-12-09 |
| 118 | The Effect of The Safe and Sound Protocol on Emotional Regulation in Traumatized Adults With Substance Use Disorders PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study will explore whether the use of the Safe and Sound Protocol (SSP) app is an effective adjunct to treatment as usual (TAU) in individuals with co-occurring substance use disorders and trauma. This study will recruit 129 participants (100 completers) randomized to receive either active or sham SSP in addition to TAU. Participants will utilize the SSP for a minimum of three hours to a maximum of five hours for a total of seven days. Data will be collected at both pre- and post-test. Data to be collected will include measures on affect, anxiety, personality, mindfulness, … |
ERIN DENEKE; | 2025-10-21 |
| 119 | GAIN-CTNNB1: A Phase I/II Open-Label Trial To Evaluate The Safety, Tolerability, and Preliminary Efficacy of Intracerebroventricular Administration of An AAV9 Based Gene Replacement Therapy in Paediatric Patients With CTNNB1 Neurodevelopmental Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this first in human, phase I/II clinical trial is to evaulate the safety, tolerability, and preliminary efficacy of AAV9 mediated gene replacement therapy (Urbagen) in paediatric patients with CTNNB1 neurodevelopmental disorder. The main questions it aims to answer are: * Is the gene therapy with Urbagen safe and well tolerated? * Does the gene therapy improve motor function, cognitive function, behavior, sleep, and/or quality of life? Participants will: * Undergo screening assessments to ensure eligibility. * Recieve a single dose of gene therapy via bilateral intracerebroventricular administration. * Recieve prophylactic immunosuppresants (methylprednisolone, … |
DAMJAN OSREDKAR; | 2026-03-25 |
| 120 | Result Of Karyotyping in Pediatric Patients With Congenital Anomalies and Developmental Delay at Assiut University Children Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational cross-sectional study is to study the results of karyotyping analysis for children presented with congenital anomalies and developmental delay aged 1 month to 12 years, the need for further genetic tastings and identification of parents who are carrier of balanced chromosomal translocations. The main question it aims to answer: What the is the incidence of congenital anomalies tested by karyotyping and the type of chromosomal abnormalities causing the clinical features. Researcher will take detailed clinical history, … |
MANAHIL SAAD MOHAMED ELKARSANI; | 2025-09-11 |
| 121 | The Relationship Between Sensory Profile and Ankle Muscle Shortness in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to investigate the relationship between sensory profile and ankle muscle shortness in children with autism. This study will feature only one group consisting of children with autism Childhood autism assessment scale will be completed with the families of the children included in the study. The tip-toe walking status of the children participating in the study will be observed and classified according to the tip-toe walking classification. The ankle muscle shortness of the children will be evaluated by Gastro-Soleus shortness measurements and sensory processing skills will be evaluated by Sensory profile. Muscle shortness measurements and sensory profile results will be compared. |
SEDA AYAZ TAŞ; | 2025-09-08 |
| 122 | Effects of Wilbarger Deep Pressure and Proprioceptive Technique (DPPT) on Motor Skills and Sleep Pattern in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: It will be conducted as a Quasi Experimental study across pediatric therapy centers, specialized autism clinics, and special schools. Using non-probability convenience sampling, the study will enroll Autistic children aged 6-10 years who exhibit sensory processing difficulties, motor skill delays, and sleep disturbances. Exclusion criteria include other neurological or developmental disorders and children with major physical problems. Motor skills will be assessed with the Bruininks-Oseretsky Test of Motor Proficiency (BOT-2), and sleep quality will be measured using the Children’s Sleep Habits Questionnaire (CSHQ). Participants will be receiving Wilbarger DPPT along with their usual therapy sessions, … |
AIZA ZAMIR; | 2025-11-25 |
| 123 | Multidimensional Assessment of Mental Health in Adolescence: Cross-sectional Study Using Self-report and Parent-report Questionnaires PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Evidence indicates that many mental disorders in adulthood originate during adolescence, with a typical onset between the ages of 14 and 18, especially for anxiety, mood, and behavioral disorders. Over the past 20 years, the prevalence of psychiatric disorders among children and adolescents has increased globally, influenced by factors such as environmental stress, digital technologies, socioeconomic inequalities, and the consequences of the COVID-19 pandemic. Approximately one in seven adolescents worldwide suffers from a diagnosable mental disorder, with a growing trend, especially in high-income countries. A multidimensional and multi-informant assessment, integrating the perspectives of adolescents and parents, … |
IRCCS CENTRO NEUROLESI BONINO PULEJO | 2026-02-20 |
| 124 | Comparative Effects Of Creative Movement & Play Based Interventions On Motor Skills, Balance And Quality Of Life In Children With Developmental Delay PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Children with developmental delay often face challenges in motor skills, balance, and overall quality of life, requiring interventions that are both effective and engaging. The purpose of this study is to improving these areas and investigating comparative effects of both creative movement and play based intervention that can help identify the most effective approach for enhancing motor abilities, balance, and overall well-being in this population |
KHADIJA LIAQUAT; | 2025-12-29 |
| 125 | Spontaneous Motor-voice Assessment in Infants Using Video and Audio Recordings PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants.. The main questions it aims to answer are: Identify voice factors among infants with newborn-detectable risk. Identify association between individual characteristics (Gestational age at birth, global function, motor-function) and voice factors. Examine unique features of voice production that are present in infants with high-risk for Cerebral Palsy (CP). Participants will be asked to upload a 3-minute videos of their child at term-age, 3.5-, … |
JILL HEATHCOCK; | 2026-03-27 |
| 126 | Effect of Sensory Integrated Therapy Exercises on Repetitive Behaviour, Communication, Social Interaction and Motor Skills in The Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study will include 30 participants whose pre and post values will be calculated. Inclusion criteria for this study is autism spectrum disorder with the age group of 5\_11 years ,female and males both are included, those who are physically handi-capped and involved in some other neurological disorder or taking hypnotic and sedative drugs will be excluded. Participants will receive sensory integrated exercises (SIT) . Outcome to be measure and analyze will be repetitive behavior, communication, … |
SAEEDA MARYUM; | 2026-02-24 |
| 127 | A Multi-center, Prospective, Compared, Randomized, Evaluator-blinded, Pilot Study to Evaluate The Effectiveness of Digital Therapeutics ‘NDTx-02’ on Executive Function in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) or Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to explore the preliminary safety and effectiveness of the digital therapeutic device ‘NDTx-02’ in supporting improvements of executive function in children and adolescents diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) or Autism Spectrum Disorder (ASD). |
YOO-SOOK JOUNG; | 2025-11-21 |
| 128 | Impact and Determinants of Success of A Mobile Multidisciplinary Intervention System Specialized in Pain Management for Patients With Moderate to Severe Intellectual Development Disorder, Isolated or Associated With An ASD or Multiple Disability – MoDIDol PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Pain is described by patients with a Neurodevelopmental Disorder (NDD), including Autism Spectrum Disorder (ASD), Intellectual Development Disorder (IDD) or multiple disabilities, and the family as one of the main associated disorders; its management is also one of the main concerns of families and professionals. At present, there is no validated and tested pain management system in populations facing complex pain situations. In response to the lack of a pain management services, a multi-disciplinary mobile team was set up in September 2022 at the Brest University Hospital (Mobile Pain Handicap Team Intellectual Disability 0-25 years; … |
PHILIPPE J LE MOINE; | 2025-12-24 |
| 129 | Examining The Effectiveness of A Dual Executive Function Training Package: Protocol for A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Executive function (EF) refers to the cognitive processes that enable goal-directed regulation of thoughts, emotions, and behaviours. Two interrelated domains are commonly distinguished: cool EF, which involves abstract cognitive processes, and hot EF, which involves regulation in emotionally or motivationally charged contexts. Children with special educational needs (SENs) frequently show difficulties across both domains, yet most interventions target one in isolation. The present study aims to evaluate the effectiveness of a dual EF training package for three of the most prevalent SENs groups: attention-deficit/hyperactivity disorder (ADHD), specific learning difficulties (SpLD), … |
EDUCATION UNIVERSITY OF HONG KONG | 2025-12-04 |
| 130 | The Modulatory Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Anxiety Responses and Emotional Regulation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main aim of this study is to investigate whether transcutaneous auricular vagus nerve stimulation (taVNS) can reduce anxiety and have an effect on emotional regulations |
SHUXIA YAO; | 2026-01-27 |
| 131 | An Open-label, Randomized, Controlled Trial to Evaluate The Efficacy of Sotatercept Add-on Therapy Compared to Standard PAH Therapy With Pulmonary Vasodilators for Pulmonary Arterial Hypertension Associated With Pulmonary Vasodilator-resistant, Unrepaired Congenital Shunts (ASD, VSD, PDA) Including Eisenmenger Syndrome：SuMILE Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: What is this study about? This study will test whether adding sotatercept to usual medicines for pulmonary arterial hypertension (PAH) can help adults who have PAH due to unrepaired congenital heart defects (atrial or ventricular septal defect, or patent ductus arteriosus), … |
KAZUYA HOSOKAWA; | 2026-01-21 |
| 132 | A Phase 2, Placebo-Controlled, Randomized, Double-Blind Study to Assess The Safety, Tolerability and Efficacy of Terpenes-enriched Cannabis Oil T1/C28, Administered to Pediatric Subjects With Autism Spectrum Disorder (ASD) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine whether cannabidiol (CBD, 28%) combined with terpenes and a small amount of THC (1%) can help reduce symptoms of autism, and to evaluate the safety of this treatment. The main questions are: 1. Does this treatment improve behavioral challenges in children with autism? 2. Does this treatment improve social difficulties in children with autism? What will happen in the study: 1. Participants take either the study treatment or a placebo (a look-alike substance with no active drug) every day for 2 months. 2. After 2 months, … |
ADI ARAN; | 2025-11-19 |
| 133 | Evaluating Efficacy of A Digital Game Based Therapeutic for Improving Socialization Outcomes in Autistic Children, A Randomized Clinical Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The following study aims to assess the efficacy of the game-based digital therapeutic, GuessWhat, in improving adaptive socialization skills in children with Autism Spectrum Disorder (ASD). GuessWhat is a mobile application (available for free for iOS and Android) which contains a suite of games: pro-social charades, emotion guessing, and quiz. Participant families will use their personal smartphones to download the app and play it with their child according to a predetermined regimen. |
DENNIS PAUL WALL; | 2025-05-15 |
| 134 | Effects of Application-Based Mindfulness and Eating Awareness Training on Disordered Eating in Youth With Obesity: The MB-EAT Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This two-phase, double-blind, balanced, parallel-group randomized controlled trial evaluates the feasibility, usability, engagement, and clinical impact of an app-based adaptation of the Mindfulness-Based Eating Awareness Training (MB-EAT) program for adolescents living with obesity. MB-EAT, has been shown to reduce binge eating episodes, improve food-related self-control, and decrease depressive symptoms in adults with obesity. The app based program promotes mindful awareness and self-regulation in response to hunger and satiety cues, … |
GARY GOLDFIELD; | 2025-08-19 |
| 135 | Effectiveness of An Artificial Intelligence-Enabled Electric Toothbrush and Visual Pedagogy Materials on Oral Hygiene of Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized clinical trial evaluates the effectiveness of an AI-enabled electric toothbrush and visual pedagogy materials in improving oral hygiene among children with autism spectrum disorder (ASD). The study compares plaque control, gingival health, and adherence between children using a manual toothbrush with visual pedagogy support and those using an AI-enabled electric toothbrush with app-based monitoring. |
MARÍLIA GOULARDINS; | 2025-09-08 |
| 136 | Combining L-theanine and Paraxanthine for Transient Improvement of Cognitive Deficits Among Patients With Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Series of Translational Pilot Neuroimaging Studies PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This pilot study will test whether combining L-theanine and paraxanthine improves sustained attention, inhibitory control, and overall cognition in adults with ADHD and ASD. Two parallel randomized, single-blinded, repeated-measures crossover trials will be conducted. Participants will complete neuropsychological testing, fMRI scanning, and self-report measures following administration of the L-theanine-paraxanthine combination compared to placebo. |
SAMUDANI DHANASEKARA; | 2026-02-05 |
| 137 | Evaluation and Refinement of KF-STRIDE Into The Interview! PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Examine the acceptability, usability, feasibility, and initial efficacy of KF-STRIDE 3.0, the data from which will serve as a basis for a future fully powered RCT |
HELEN GENOVA; | 2025-09-11 |
| 138 | A Target Engagement Study of Pimavanserin for Behavioral Inflexibility With Open Label Trial for Rigid Rigid-compulsive Behavior in Adolescents and Adults With Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This Phase 2 study examines the safety, tolerability, and preliminary efficacy of pimavanserin in individuals with Autism Spectrum Disorder. Male or female participants aged 12 to 40 years of age will be randomized to receive single doses of either placebo or pimavanserin in this randomized, placebo-controlled, cross-over designed study, followed by open label extension. |
JEREMY VEENSTRA-VANDERWEELE; | 2026-04-01 |
| 139 | Intravenous Injection of Human Bone Marrow Mesenchymal Stem Cell (hBMMSC) in The Treatment of Autism Spectrum Disorder (ASD): An Exploratory Study on The Safety and Preliminary Efficacy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial aims to evaluate the safety and preliminary efficacy of intravenous administration of human bone marrow-derived mesenchymal stem cells (hBMMSCs) in patients with autism spectrum disorder (ASD). |
JIUZHITANG MAKER BEIJING CELL TECHNOLOGY | 2025-09-17 |
| 140 | Cultural Adaptation of Parent Training Intervention for Spanish-Speaking Families PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Supporting young autistic children can sometimes be very stressful, especially when children show behaviors that are difficult to understand and/or manage in everyday life. Research has shown that teaching parents practical strategies through programs like the Research Units in Behavioral Intervention (RUBI) can reduce these behaviors and help parents feel more confident. However, most of these programs have only been studied with English-speaking families, … |
GOSPEL KIM; | 2025-09-22 |
| 141 | Comparison of Efficacy and Safety of Vita 6 Versus Zinc Along With Applied Behavioural Therapy in Management of Autism Spectrum Disorder in Children Aged 3-14 Years PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study seeks to fill the gaps in available local data regarding the diagnosis and its management, as multiple treatments are in practice. Therefore, the study aimed at the comparison of efficacy and safety of Vita 6 versus zinc along with applied behavioral therapy in the management of autism spectrum disorder in children aged 3-14 years. |
MUHAMMAD AAMIR LATIF; | 2026-02-03 |
| 142 | Meeting The Needs of Young Hispanic Autistic Children: Developing A Culturally and Linguistically Sensitive Intervention to Alleviate Core Social Challenges PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose of the Study: The goal of this clinical trial is to find out if a technique called the mutual gaze procedure used in a Culturally and Linguistically Responsive adaptation of Pathways Early Intervention (CLR-Pathways) is the key to improving social communication, language, … |
PAMELA ROLLINS; | 2025-11-05 |
| 143 | Water Competency Intervention for Children on The Autism Spectrum: The AquOTic Hybrid Effectiveness Implementation Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: AquOTic is an evidence-based, occupational therapy-led intervention designed to enhance water competency and swim safety skills in children on the autism spectrum. The 10-week program consists of weekly 60-minute group sessions, each including six children paired in a 1:1 ratio with an interventionist. Sessions follow a structured routine involving six rotating stations, targeting various swim and safety skills, with the flexibility for individualized support by the interventionist. Overall, this study has 3 major aims. The first aim evaluates the effectiveness of the AquOTic intervention in improving water competency and swim skills, … |
JEWEL CRASTA; | 2025-12-04 |
| 144 | Multicenter Validation Study on The Effectiveness of A Machine-Assisted System for Early Screening of Autism PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to assess the effectiveness of a machine-assisted system for early screening of autism. The main questions it aims to answer are: * Does the machine-assisted system including 5 main behavioral paradigms identify toddlers with autism from those with other neurodevelopmental disorders and typical development? * Are there any differences in the early symptoms of autism among toddlers over the whole mainland China? Participants will receive some developmental and social communicational evaluations for clinical diagnoses. They will also receive the behavior evaluations of the machine-assisted system. The above evaluations will be performed just once. |
XIU XU; | 2025-09-16 |
| 145 | Prevalence of Neurodevelopmental Disorders in A Homeless Population – Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction \& Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder). Methods / approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, … |
CAROLINE DEMILY; | 2025-08-01 |
| 146 | The Modulatory Affect of Oxytocin on Human Defensive Responses During Dynamic Predator-prey Interactions PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The presnet study is to investigate the effect of intranasal oxytocin (24 IU) treatment on modulating how human responsd to threat in a dynamic situation. |
SHUXIA YAO; | 2025-10-06 |
| 147 | Individual Differences in Cognitive Control Predict Real-time FMRI Neurofeedback Performance PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to investgate whether individual differences of cognitive control capacity could predict neurofeedback performance and the behavioral effects resulting from successful anterior insula regulation via interoceptive strategy. |
SHUXIA YAO; | 2025-10-07 |
| 148 | Evaluating Georgia Part C Implementation Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to answer the question: What is the best way to help Early Intervention (EI) providers deliver high-quality services to children with communication delays for autism? The primary goal of this project is to examine the outcomes associated with delivering Project ImPACT, an evidence-based autism intervention that is delivered as part of routine training within Georgia’s EI system. Providers in the study will receive one of two Project ImPACT training models to help us understand which training model helps providers learn Project ImPACT better. Specifically, … |
KATHERINE E. PICKARD; | 2025-12-09 |
| 149 | Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This is a large-scale observational study aiming to evaluate the long-term effectiveness and safety of Fecal Microbiota Transplantation (FMT). FMT is a procedure that transfers gut bacteria from healthy donors to patients to restore a balanced gut microbiome. The study will follow approximately 4,000 patients who have received or will receive FMT for conditions like recurrent C. difficile infection, inflammatory bowel disease, functional gastrointestinal disorders, and certain neurological conditions. The main goals are to: * Assess the disease remission rates at 3 months, 1 year, … |
CHEN QIYI; | 2025-12-03 |
| 150 | Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder with extensive clinical and genetic heterogeneity that is still poorly understood. The phenotype includes hypotonia, delayed psychomotor development, intellectual disability of varying severity, and consistent language impairment ranging from delayed to absent speech. Autism spectrum disorders are present in 60-80% of patients, and other comorbidities may be present. The major candidate gene for PMS is SHANK3, which encodes a scaffolding protein in the dense postsynaptic region of glutamatergic synapses. Its loss of function is caused by deletions in the distal region of chromosome 22, 22q13.3, or by intragenic genomic variants. Several studies, … |
ANNE-CLAUDE TABET; | 2025-08-13 |
| 151 | The Influence and Regulatory Role of Exogenous and Endogenous Oxytocin on Top-down Attention in Humans PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main aim of the present study is to investigate whether orally (lingual spray) administered oxytocin influences human top-down attention via oxytocin receptors and whether its effects are dose- and task-dependent. |
KEITH KENDRICK; | 2025-09-08 |
| 152 | Where Wild Things Grow: Immediate and Long-term Impact of Nature- and Activity-based Group Interventions for Neurodivergent Children and Youth in School, Health Care and Leisure Settings in Agder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this action research project is to develop and implement nature- and activity-based group interventions across health care, school and leisure settings in Southern Norway. The interventions are tailored to support the mental health, self-efficacy and daily life functioning of children and youth in the Agder region, with a particular focus on youngsters who struggle due to neurodivergence, such as Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) or Tourette’s syndrome. The main questions we aim to answer are: 1. To what extent does nature- … |
CARINA R FERNEE; | 2025-10-02 |
| 153 | Intelligence and Neurodevelopmental Outcome After Prenatal Exposure to Labour Epidural Analgesia: A Sibling Matched Clinical Ambidirectional Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In Belgium, labour epidural analgesia (LEA) has been used for decades in the vast majority of vaginal deliveries (up to 83% of deliveries). Labour epidural analgesia is the most effective and safest way to allow pregnant women a nearly pain-free labour- and birth experience. Recent data showed that the use of LEA was associated with a reduced risk for severe maternal morbidity, neonatal resuscitation and with a reduced risk for low Apgar scores. However, prenatal exposure to labour epidural analgesia has been associated by several study groups with an increased risk for autism spectrum disorder (ASD) in the children, … |
UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN | 2025-06-11 |
| 154 | Resting-State Functional Connectivity As A Predictor of TDCS Effects in Adolescents With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation that has aroused increased interests in the past decade. Not only that it is transient with little side-effects, and can be well-tolerated by children, it is also affordable and readily accessible, making it an appealing treatment option for autism spectrum disorder (ASD). Objective: (1) To evaluate the therapeutic effects of tDCS on improving cognitive function in patients with ASD, (2) to better understand the neural mechanisms underlying the neuromodulation effects of tDCS in patients with ASD, … |
YVONNE HAN; | 2025-09-24 |
| 155 | The Intervention of Lactobacillus Plantarum Probiotics in Adult Patients With Autistic Spectrum Disorders Investigating Associations of Microbiota, Inflammation, Social Interactions, Quality of Life, and Gait Analysis: A Qualitative and Quantitative Mixed & A Double-blind Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a qualitative and quantitative mixed-methods, open-label study, will involve 12 participants and their caregivers. Participants will also undergo blood exams and gait analysis, while caregivers will complete qualitative interviews and quantitative questionnaires on autistic symptoms, stress, anxiety, and quality of life. After the baseline assessments, participants will receive Lactobacillus plantarum for 8 weeks, followed by further evaluations at end point. |
SHU-I WU; | 2025-08-12 |
| 156 | Comparing Single and Dual Task Effects in Children With Autism Spectrum Disorder and Typically Developing Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the effects of single-task and dual-task conditions on motor performance and postural control in children with Autism Spectrum Disorder (ASD) and typically developing children. Participants’ performance under single-task and dual-task conditions involving cognitive load will be evaluated to examine how cognitive demands affect physical task performance in both groups. |
GAMZE DEMIRCIOĞLU; | 2026-02-06 |
| 157 | A Randomsized Controlled Study on The Effects of Combined Fecal Microbiota Transplantation on Gut Microbiota and Eating Disorder Symptoms in Patients With Anorexia Nervosa PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine if Fecal Microbiota Transplantation (FMT) is effective in treating Anorexia Nervosa (AN). The study will also explore how FMT works. The main questions it aims to answer are: 1. What is the efficacy of combined FMT treatment in patients with AN? 2. What is the relationship between treatment efficacy and changes in gut microbiota, … |
SHANGHAI MENTAL HEALTH CENTER | 2025-08-19 |
| 158 | Effects of Transcranial Direct Current Stimulation (tDCS) for Enhancing Cognitive Function in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Transcranial Direct Current Stimulation (tDCS) is a form of non-invasive brain stimulation that has aroused increased interests in the past decade. Not only that it is transient with little side-effects, and can be well-tolerated by children, it is also affordable and readily accessible, making it an appealing treatment option for autism spectrum disorder (ASD). Objective: (1) To assess the therapeutic effects of tDCS when combined with cognitive training for 10 consecutive weekdays on improving cognitive processing in children with ASD, relative to control group receiving sham-stimulation, … |
YVONNE HAN; | 2026-02-06 |
| 159 | Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders. Behavioural and Psychophisiological Measures PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary aim of this observational study is to investigate specific aspects of social cognition in dystrophinopathies. Body awareness, interpersonal distance and emotional processing will be measured in a sample of patients affected by Becker (BMD) and Duchenne (DMD) muscular dystrophy, compared with a sample of patients affected by osteogenesis imperfecta (OI), and both compared with a control sample with typical development. The secondary aim is to study cortical activity at rest, by means of electroencephalography (EEG), to explore frequencies and time course of EEG responses. Moreover, the relationship between EEG activity and neuropsychological, … |
IRCCS EUGENIO MEDEA | 2025-03-13 |
| 160 | Effects of The Structured Sherborne Developmental Movement Program on Sensory Processing, Motor Performance, and Functional Status in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study was to investigate the effects of the Structured Sherborne Developmental Movement Program on sensory processing, motor performance and functional status in children with autism spectrum disorders. |
ELIF DILAN ATILGAN; | 2026-03-18 |
| 161 | Investigating The Therapeutic Efficacy of All-trans Retinoic Acid in Autism Spectrum Disorder Patients With 15q11-13 Duplication Syndrome PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Autism spectrum disorder (ASD) , hereafter referred to as autism, is a group of neurodevelopmental disorders caused by genetic and environmental factors. Its core symptoms are social impairment, repetitive stereotyped behaviors, and restricted interests. The 15q11-13 region of the human chromosome is a locus prone to structural abnormalities leading to neurological disorders. Maternal duplications within this region lead to Dup15q syndrome , which accounts for approximately 1% of ASD cases . This region harbors multiple alleles, and current research indicates that the pathophysiological alterations in this syndrome primarily involve UBE3A . Among all genes in the 15q11-13 region, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-07-23 |
| 162 | A Proof of Concept Study : Open Label Phase IIa Trial Evaluating The Effect and Safety of Transplantation of Fecal Microbiota in Children With Autism Spectrum Disorders and Gastrointestinal Symptoms Related Papers Related Patents Related Grants Related Experts Highlight: Autism Spectrum Disorders (ASD), affect approximately 1% of the general population and are characterized by impairments in social communication associated with repetitive/stereotyped behaviors. Approximately one-third of these patients display gastrointestinal (GI) symptoms, and a growing number of studies suggest abnormalities of gut microbiota in ASD. Gut microbiota and the brain interact through complex pathways. Preliminary evidence in adults with ASD suggests that modulation of the gut microbiota by probiotics and/or prebiotics and more recently by fecal microbiota transplantation could improve GI symptoms but also socio-communication deficit, with persistent improvement at year 2. |
PIERRE ELLUL; | 2025-08-05 |
| 163 | Community-Engaged Behavioral Sleep and Circadian Intervention for School-Aged Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: As many as 78% of children with autism spectrum disorder (ASD) have significant sleep disturbance compared to 20% of children without ASD. In children with ASD, shorter sleep duration and lower sleep efficiency, are associated with disruptive behavior, anxiety, and increased parental stress. Therefore, multiple sleep dimensions (B-SATED: behaviors, satisfaction, alertness, timing, efficiency, duration) are appropriate therapeutic targets to improve daytime behavioral functioning and other psychosocial outcomes. The primary objective is to evaluate the implementation of a modification of a behavioral sleep and circadian intervention to improve multiple sleep dimension in school-age children with ASD. To accomplish this objective, … |
MEGAN WENZELL; | 2025-12-22 |
| 164 | Opt In – Implementation and Evaluation of An Early Intervention Program for Children Waiting to Receive An Autism Diagnosis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: A growing body of literature documents the benefits of parent-mediated interventions for autism starting early in life . However, the median age of diagnosis in the US continues to be 49 months. Even following formal diagnosis, services often do not begin for another 9 months on average. Such harmful delays in accessing autism-specific early interventions are potentially avoidable, as caregivers of children later diagnosed with autism identify concerns about their child’s development by 13 months on average – … |
DREXEL UNIVERSITY | 2026-01-28 |
| 165 | ADAPT: Approach to Dance for Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: It is well documented that motor impairments are associated with a diagnosis of autism spectrum disorder (ASD). Yet, appropriate therapies are scarce. Dance has been shown to not only promote fine and gross motor skills, but also psychological well-being, cognition, and social participation in neurotypical dancers. Little research has been conducted to gauge if these benefits translate to those with ASD. Ballet for all Kids (BFAK) is a recreational dance program that has been teaching ballet to children with ASD for over a decade, … |
ALEXANDER KOLEVZON; | 2025-10-15 |
| 166 | Effects of CTBS on Sensory Integration in Children With Autism Spectrum Disorder: A Randomized, Sham-Controlled Study Integrating Genetic Markers, MRI, FNIRS, and Temporal Binding Tasks PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to find out if brain stimulation can help improve sensory integration in children ages 6 to 12 with autism spectrum disorder (ASD). The main questions it aims to answer are: Does brain stimulation using continuous theta-burst stimulation (cTBS) on bilateral dorsolateral prefrontal cortex (DLPFC) improve how children process sights and sounds together? Can brain functioning, structure, … |
NEUROLAB PLUS | 2025-09-19 |
| 167 | DBT Skill Training for Autistic Adults With Difficulties in Emotion Regulation: A Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: One in 44 has autism, 70% of them have additional mental health challenges. Currently, this patient population does not have access to effective treatment within specialist healthcare services and has struggled to benefit from standard treatments. The goal of this project is to increase access to treatment tailored to their challenges. We will investigate whether a treatment program with an adapted version of Dialectical Behavior Therapy (DBT) is feasible, accepted, and perceived as useful for people with autism. The purpose of the treatment is to improve emotion regulation, function better in relationships, and avoid crises, … |
HELSE MØRE OG ROMSDAL HF | 2025-07-15 |
| 168 | A Chatbot-based Program to Promote Well-being in Caregivers of Children With Autism Spectrum Disorder PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Autism spectrum disorder (ASD) is characterized by varying degrees of disability and deviation in social communication, cognitive growth, and emotional expression, as well as the existence of constrained, repetitive patterns of behavior and interests and sensory processing issues. Caring for children with ASD can be a stressful and challenging life event for parents, potentially leading to a higher risk of mental health issues and other negative outcomes. Poor mental health in these parents can be attributed to various factors, such as the perception of having little control over their child’s behavior, … |
WENDY ZHANG WEN; | 2025-12-17 |
| 169 | The Effects of A Nurse-led Community-based Sailing Programme on Resilience of School-aged Children With Autism: A Randomised Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomised controlled trial is to evaluate the effect of a nurse-led community-based sailing programme on resilience of school-aged children with autism in inclusive education. Does intervention improve the resilience of participants? Does intervention improve the quality of life, self-esteem, depressive symptoms, and social functioning outcomes of participants? Researchers will compare the effect of intervention (community-based sailing programme) to the attention control group (Crafting activities) at baseline, post-intervention, and at 3-month and 9-month follow-ups. Participants will: Participants in the intervention group will participate in a nurse-led community-based sailing programme over six days, … |
MYRIAN SZE NGA FAN; | 2025-07-09 |
| 170 | Anorexia Nervosa and Autism – A Care Location Adapted for Both Conditions PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In a pilot study, the investigators will validate a so-called autism care location in an inpatient ward. The care location will be adapted for patients with anorexia nervosa (AN) and concurrent autism (AN+autism). In order to investigate the effect of a tailored care location for patients with AN + autism, the evaluation will include weight development and changes in nutritional intake, eating disorder and anxiety symptoms. The overall aim is to improve treatment for this specific AN subgroup, that otherwise has a worse prognosis regarding AN recovery. |
GÖTEBORG UNIVERSITY | 2025-04-09 |
| 171 | A Mixed-Methods Open-Label Trial Evaluating The Effects of Neuralli® MP on Self-Defined Outcomes in Adults With Autistic Traits PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy of Neuralli® MP in improving participant-defined outcomes in adults with autistic traits. |
SHU-I WU; | 2025-08-08 |
| 172 | M.I.N.E.R.V.A., Metodologie Innovative Per La Neuroplasticità in Età Evolutiva Con L’Uso Della Realtà Virtuale A Scopo Abilitativo PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Neurodevelopmental disorders, such as Cerebral Palsy (CP), Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), are complex conditions that affect various aspects of children’s development. Despite advancements in treatments, conventional rehabilitative interventions tend to focus on specific aspects, often overlooking the holistic needs of the patient. Many of these interventions fail to engage children, who may feel uninvolved or demotivated. Innovative technologies, such as immersive virtual reality (IVR), offer a promising alternative to make rehabilitation more engaging and comprehensive. This study aims to evaluate the effects of IVR-based rehabilitation on children and adolescents with neurodevelopmental disorders, focusing on improvements in cognitive, … |
IRCCS CENTRO NEUROLESI BONINO PULEJO | 2026-02-23 |
| 173 | The Accuracy of Portable Sleep Monitoring for Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to evaluate the ability of a portable sleep monitor to detect obstructive sleep apnea in children with autism spectrum disorder (ASD). The main study objectives are to: 1. Evaluate the correlation between the obstructive apnea-hypopnea index (OAHI) on a portable sleep monitor and an in-laboratory polysomnogram (PSG); 2. Determine the sensitivity and specificity of a portable sleep monitor to diagnose obstructive sleep apnea (OSA); 3. Evaluate patient and family preferences for sleep testing. |
LENA XIAO; | 2026-01-26 |
| 174 | Scalp Acupuncture Treatment for Chronic Tic Disorders in Children: A Multicenter Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if scalp acupuncture works to treat chronic tic disorders (CTD) in children. It will also learn about the safety of scalp acupuncture. The main questions it aims to answer are: * Does scalp acupuncture improve clinical symptoms and social functioning, … |
HAO ZHOU; | 2025-07-23 |
| 175 | Developing and Examine The Efficacy of The Family-Centered Multi-Sensory Environment Intervention on Parent’s Empowerment and Children’s Engagement (MSE-PEACE) in Children With Developmental Disabilities and Their Parents: A Mixed Methods Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether a family-centered multi-sensory environment (MSE-PEACE) can help children with developmental disabilities and support their parents. The main questions it aims to answer are: Can the MSE-PEACE program improve children’s participation and emotional self-regulation? Does it help parents feel more confident and empowered in their caregiving role? Participants will include children ages 3 to 12 years and their parents. All children have been diagnosed with a developmental disability such as autism, ADHD, or cerebral palsy. Participants will: Join 10 multi-sensory sessions, held every 2 weeks, … |
LING-YI LIN; | 2025-08-12 |
| 176 | Psychotherapy Group for Parents of Children With Leber Congenital Amaurosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objectives of this study are to evaluate the effect of a group psychotherapy intervention for parents of children/adolescents with LCA on indicators of emotional health, parental stress, acceptance, cognitive defusion, and mindfulness. The study design is a repeated measures design with pre-, post-, and 3-month follow-up assessments. Forty parents of children and adolescents with LCA will be included in the sample. Twenty will participate in the psychotherapy groups, divided into 2 groups of 10 people, and 20 will be in the control group. To assess the indicators mentioned in the objective, the following questionnaires will be applied: Self-Reporting Questionnaire, … |
CECÍLIA F VASCONCELLOS; | 2025-06-18 |
| 177 | Exploration of The Neural Correlates of Social Expertise: An Fmri Study Comparing Healthy Individuals With Different Levels and Types of Expertise PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Social interaction is supported by several brain regions, which are involved in encoding socio-perceptual information, attributing affective and mental states to other conspecifics, and ultimately enabling the orchestration of an appropriate response. In this view, cognitive control mechanisms are necessary to select relevant information, allocate resources, and generate inferences. There is a close link between the mechanisms underlying social cognition and social conceptual knowledge, relating, for example, to abstract concepts such as friendship. For example, children with autism spectrum disorder (ASD) show impairments in social interactions, … |
JUBIN ABUTALEBI; | 2025-08-08 |
| 178 | A Pilot Trial of The Individualized Placement and Support Model in Autistic Adults in The Community PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to enhance employment outcomes for young adults with autism and intellectual and developmental disabilities (IDD) through the implementation of an evidence-based supported employment model known as Individual Placement and Support for Autism (IPS-AUT). The study will evaluate the feasibility, acceptability, and effectiveness of IPS-AUT in promoting Competitive Integrated Employment (CIE). The trial will involve partnerships with supported employment agencies, training providers in IPS-AUT, and assessing employment outcomes and implementation factors. The ultimate goal is to create a scalable, evidence-based employment support model for individuals with autism. |
MARJORIE SOLOMON; | 2026-01-28 |
| 179 | Effects of Systematic Exercise Training on Core Symptoms, Executive Function and Brain Function in Children With ASD PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Studies have shown that children with ASD simultaneously have deficits in overall executive function and impairments in basic motor skills, which have a negative impact on cognitive and social all-round development. In recent years, intervention measures for the motor skills of children with ASD have gradually developed. However, based on the existing literature, there is still a lack of recommendations for sports training at present. The sustained effect of exercise intervention training on the core symptoms of ASD remains unclear. In terms of executive function, … |
CHEN LI; | 2025-08-14 |
| 180 | Explore The Impacts of One Session and Multiple Session Theta Burst Stimulation Over Cerebellum in Adults With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to establish a personalized theta burst stimulation (TBS, an advanced variant of repetitive transcranial magnetic stimulation, rTMS) protocol considering autistic idiosyncrasy (interindividual variability). |
HSING CHANG NI; | 2025-08-11 |
| 181 | Expediting Access to Autism Specific Intervention for Young Autistic Children Living in Rural North Carolina: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to assess whether telehealth-based Family Navigation (FN) expedites enrollment (e.g., reduces time in days) in community-based autism intervention for toddlers under the age of 4 living in Rural NC after their initial diagnosis of autism. The main questions it aims to answer are: Does Family Navigation decrease the time to initiation of intervention for rural toddlers with autism? Does Family Navigation improve developmental outcomes at 18 months post-diagnosis of autism? Does Family Navigation improve caregiver well-being? Caregivers in the Family Navigation condition will receive 4 research-based individual sessions with a trained navigator to support them in identifying and enrolling in recommended autism early intervention services. All navigation sessions will be delivered virtually via phone/Zoom. Researchers will compare participants who receive family navigation to participants who receive the standard of care (educational materials) to see if family navigation outperforms the standard of care. |
KELLY CARAVELLA; | 2025-10-29 |
| 182 | Empowering Caregivers to Promote Child Independence and Persistence With Activities PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed study aims to address the unique needs of caregivers and their adolescent children with profound autism. The constant supervision and 24/7 care that caregivers need to provide their children to ensure their health and safety often leaves little time for household duties, self-care routines, and spending time with family and friends. Investigators aim to alleviate the vigilant monitoring provided by caregivers for brief periods by increasing their child’s independent, … |
ALICE SHILLINGSBURG; | 2025-10-10 |
| 183 | Evaluating A Spanish-language Executive Functioning Intervention for Children With Autism And/or ADHD and Their Families PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn whether the Spanish-language version of Unstuck and On Target (SL-Unstuck), an executive functioning (EF) intervention, is feasible, acceptable, and effective for Spanish-speaking caregivers and their neurodivergent children (ages 8-11) in the U.S.. The main questions it aims to answer are: * Is SL-Unstuck acceptable to Spanish-speaking caregivers and children? * Does SL-Unstuck improve child EF, caregiver EF knowledge, … |
JONATHAN SAFER-LICHTENSTEIN; | 2026-04-03 |
| 184 | The Effects of A Nurse-led Community-based Sailing Programme on Resilience of School-aged Children With Autism: A Pilot Randomised Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this pilot RCT is to evaluate the feasibility and acceptability of the community-based sailing program and to assess the preliminary effects before the main RCT, given the literature on sailing for children with ASD has not yet been established. Does intervention improve the resilience of participants? Does intervention improve the quality of life, self-esteem, depressive symptoms, and social functioning outcomes of participants? Researchers will compare the effect of community-based sailing to the attention control group at baseline, following randomisation, … |
MYRIAN SZE NGA FAN; | 2025-07-02 |
| 185 | A Randomized Controlled Interventional Study on The Effects of Spirulina Supplementation on Anxiety in Children With Non-Idiopathic Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate the effect of a Spirulina syrup formulation on reducing anxiety in children with non-idiopathic autism. Participants are referred to a private clinic and assessed by a pediatric neurology subspecialist to confirm the diagnosis. Informed consent is obtained from the parents. Patients are randomly assigned to two groups. The intervention group receives standard treatment (Risperidone tablets) plus Spirulina syrup, while the control group receives Risperidone plus a placebo. Anxiety is measured using the parent version of the Spence Children’s Anxiety Scale (SCAS), … |
SANAZ ALAMDAR; | 2025-07-11 |
| 186 | Development of An Intervention Aimed at Facilitating The Use of Eye Contact in Adults With Autism: A Qualitative Study With Methodological Triangulation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to develop a methodological intervention for adults with autism that will help them reduce problems arising from eye contact. |
JOS BOER; | 2025-04-11 |
| 187 | Brain STimulation for ANxiety and Depression in Youth: Brain STAND PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this open-label trial, the overall aim is to determine if TMS treatment can improve anxiety and depression in a broad group of children and youth referred by physicians. |
KARA MURIAS; | 2026-01-29 |
| 188 | Rural Autistic Individuals – Supporting Expression PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research study investigates how hand gestures can support language comprehension and communication skills of hearing speaking, non-speaking, and/or minimally verbal individuals with Autism Spectrum Disorders (ASD), who are especially disadvantaged by the lack of accessible services in their rural communities. Individuals with other cognitive profiles, including Developmental Language Disorder (DLD), ADHD, Dyslexia, and others are welcome too. The study uses methods of eye tracking and recording of brain activity to understand how hand gestures adapted from signs from American Sign Language, such as \[cry\], … |
NADEZHDA MODYANOVA; | 2025-07-10 |
| 189 | A Prospective, Single-Center, Single-Arm, Investigator-Initiated Exploratory Clinical Trial to Assess The Safety of Repetitive Transcranial Magnetic Stimulation for Children and Adolescents With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective, single-center, single-arm, investigator-initiated exploratory clinical trial aimed at evaluating the safety and exploring the efficacy of a medical electromagnetic stimulator delivering low-frequency repetitive transcranial magnetic stimulation (rTMS) in children and adolescents with Autism Spectrum Disorder (ASD). ASD is a neurodevelopmental disorder characterized by deficits in social interaction and communication and restricted, repetitive behaviors. Despite increasing prevalence, effective treatment options remain limited, and the demand for non-invasive, safe interventions continues to grow. In this study, … |
MINYOUNG KIM; | 2025-05-21 |
| 190 | Developing An EEG-fNIRS Neurofeedback Application for Brain Training for Autistic Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to learn if a new brain training method, called combined electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) neurofeedback, can improve thinking, emotions, and social functioning in children with autism spectrum disorder (ASD). It will also learn if this training is practical and safe to use with children in Hong Kong. The main questions this study aims to answer are: * Does combined EEG-fNIRS neurofeedback improve attention, emotion regulation, … |
YEUNG KIN CHUNG MICHAEL; | 2025-09-08 |
| 191 | Neuroanatomical Differences Associated With Anorexia Nervosa and Masking Behaviour in Autistic Individuals PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Masking is a behaviour or strategy used by many Autistic people to appear non-Autistic and blend in with a neurotypical society. The goal of this observational study is to understand the relationship between masking, … |
MICHELLE SADER; | 2025-08-01 |
| 192 | Temporal Pole Transcranial Alternating Current Stimulation for Children With Autism Spectrum Disorder: A Randomized Controlled Open-Label Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this open-label randomized controlledl trial is to explore the safety and efficacy of conventional transcranial alternating current stimulation (tACS) and transcranial temporal interference stimulation (tTIS) targeting the temporal pole in children with autism spectrum disorder (ASD) in China. The main questions it aims to answer are: \*Can tACS and tTIS safely and effectively improve clinical symptoms in children with autism? Researchers will compare the tACS group and tTIS group with control group to explore the safety, … |
FEI LI; | 2026-03-25 |
| 193 | Investigating The Effects of Music Therapy on Sensory Processing, Adaptive Behavior and Social Interaction in Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of our study is to examine the effects of music therapy on sensory processing, adaptive behavior, and social interaction in individuals with autism. |
LEYLA KAYA OZTURK; | 2025-07-31 |
| 194 | Developing Cognitive Control and Metacognition to Reduce The Functional Impact of Restricted and Repetitive Behaviors in Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: 95 autistic children (ages 8-11yrs) will be randomly assigned to a novel computer-based Cognitive Control Training combined with Metacognition Coaching or to a comparison group that receives the intervention after a delay. Before and after intervention, electroencephalography (EEG) will be used to examine engagement of the target neural responses. |
SUSAN FAJA; | 2025-03-20 |
| 195 | An Open-label, Single Arm, Dose-Escalation Clinical Study to Evaluating The Safety, Tolerability and Preliminary Efficacy of A Single Intracerebroventricular Injection of RB001 for The Treatment of SHANK3-related Phelan McDermid Syndrome Related Papers Related Patents Related Grants Related Experts Highlight: This is a first in human, open-label, dose-escalation study to evaluate the safety, tolerability, and clinical activity of a single dose of RB001 administered via intracerebroventricular (ICV) injection in pediatric with SHANK3 related Phelan-McDermid Syndrome. Clinical data will be evaluated for safety, tolerability, and preliminary efficacy of RB001 in participants with SHANK3 related PMS. |
YE WU; | 2025-07-30 |
| 196 | Scalable, Clinician-Supervised Generative-AI Food-Chaining Assistant for Pediatric ARFID: A Pilot Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Children with Avoidant/Restrictive Food Intake Disorder (ARFID) often lack access to specialty dietitians, and scalable nutritional guidance/food chaining tools are currently not available. The investigators will evaluate a web-based, clinician-supervised, generative-AI assistant that produces individualized food-chaining plans. Develop an AI assistant that generates ≥15 allergy-safe, … |
PAUL CROWLEY; | 2025-06-06 |
| 197 | Effects of A Virtual Reality-Based Self-Modeling Intervention on Social Communication Skills in Children With Autism Spectrum Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impairments in social communication and interaction, as well as restricted and repetitive behaviors. Behavioral and educational interventions are considered the most effective approaches to improve functional outcomes in children with ASD. However, … |
ILKNUR UCUZ; | 2026-04-01 |
| 198 | Assessment Of Spinal Posture, Balance And Ankle Muscle Shortness İn Children With Autism PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to evaluate spinal posture, mobility, balance and ankle muscle shortness in children with autism. The study will feature two groups, * First group will consist of children with autism * Second group will consist of typically developing children Childhood autism assessment scale will be completed with the families of the children included in the study. The tiptoe walking status of the children participating in the study will be observed and classified according to the tiptoe walking classification. Children’s balance skills will be evaluated with pediatric berg balance test and timed get up and walk test, ankle muscle shortness will be evaluated with Gastro-Soleus shortness measurements, spinal posture and mobility will be evaluated with spinal mouse. The evaluation results of both groups will be compared. The main questions this study aims to answer are: * Is spinal mobility decreased in children with autism compared to typically developing children? * Is Thoracic kyphosis greater in children with autism compared to typically developing children? * Are Balance skills poorer in children with autism compared to typically developing children? * Does the severity of tiptoe walking increase as gastro-soleus muscle shortness increases? |
SEDA AYAZ TAŞ; | 2025-09-10 |
| 199 | Measuring The Effects of Medication and Behavioral Treatments for Challenging Behavior PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The overall objective is to evaluate and compare the efficacy of two common treatments for CB in children and adolescents with autism using multiple outcome measures. Our central hypothesis is that both behavioral treatment and medication will produce reductions in CB, but behavioral treatments, including behavior treatment + medication, … |
MATTHEW J O’BRIEN; | 2025-06-17 |
| 200 | The Efficacy of Parent Management Training to Treat Irritability PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to see if 12 sessions of a Parent Management Training program can treat irritability in children aged 10-14 years old. The main question it aims to answer are: * Can a Parent Management Training for parents reduce anger outbursts and cranky moods in their children? * Can Parent Management Training be done in an outpatient clinic and do parents like it? Up to 18 families can join this study. This study will be used to set up a larger study in the Fall of 2025. Parent participants will complete 12 sessions of Parent Management Training for Irritability. Each session will be 45-55 minutes weekly. They will also participate in the assessments of their child before, during and after treatment. Child participants will do assessments before, during and after the Parent Management Training treatment. |
JOEL STODDARD; | 2026-01-07 |