Clinical Digest: Recent Clinical Trials on Meningitis (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Meningitis. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Meningitis (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Prophylactic Use of Intrathecal Calcium Channel Antagonist Through Lumbar Drain in Patients With Subarachnoid Hemorrhage Due to Aneurysmal Rupture PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine the effectiveness of prophylactic administration of intra-thecal nicardipine though lumbar cerebrospinal fluid drain in prevention of symptomatic vasospasm in patients with subarachnoid hemorrhage due to rupture of cerebral aneurysms. |
KRISHNA JOSHI; | 2026-02-23 |
| 2 | Liposomal Amphotericin B and Flucytosine Antifungal Strategy for Talaromycosis (LAmB-FAST) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: LAmB-FAST is a factorial randomized controlled trial simultaneously testing two interventions in one trial. LAmB-FAST seeks to inform treatment guidelines on the induction and maintenance therapy of HIV-associated talaromycosis (formerly called penicilliosis) and will answer the following three questions: 1. Is induction therapy using a single 10 mg\\/kg dose of liposomal amphotericin B (LAmB) is more effective than 14 days of the conventional deoxycholate amphotericin B (DAmB)? 2. Is adding flucytosine (5FC) to amphotericin B more effective than amphotericin B alone? 3. Is HIV viral load guided stopping of itraconazole maintenance therapy as effective as the current CD4 guided strategy in the prevention of talaromycosis relapse? |
THUY LE; | 2025-12-17 |
| 3 | Efficacy and Safety of Intracalvariosseous Combined With Intravenous Injection of Antibiotics in Moderate-to-Severe Bacterial Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Multiple preclinical and clinical studies, including the investigators’ published work and the ongoing SOLUTION series, have consistently demonstrated that intracalvariosseous (ICO) injection can markedly increase drug exposure within the central nervous system with acceptable safety. This trial is designed to further evaluate the efficacy and safety of antibiotic delivery via the ICO route in the treatment of bacterial meningitis, particularly in patients with moderate-to-severe disease who have shown an inadequate response to standard therapy. |
YILONG WANG; | 2026-03-27 |
| 4 | An Observational Registry-Based Study to Evaluate The Long-Term Safety of Tofersen in People With SOD1-ALS PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, researchers will learn more about the safety of tofersen, also known as Qalsody®. This is a drug available for doctors to prescribe for participant with a certain type of amyotrophic lateral sclerosis, also known as ALS. This type is in participant who have a mutation in the superoxide dismutase 1 gene, also known as SOD-1. This is known as an observational study, … |
ALEX SHERMAN; | 2026-03-02 |
| 5 | Evaluation of The Efficacy of Corticosteroids in Septic Arthritis in Adults: Randomized Double-blind Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Septic arthritis is a severe infection associated with significant morbidity and mortality. Despite eradication of the microorganisms, persistent inflammation may lead to substantial long-term functional joint sequelae. The use of corticosteroids could reduce this inflammation, thereby improving functional joint outcomes and facilitating first-line medical treatment. The hypothesis of this study is that corticosteroid administration, in addition to antibiotic therapy, reduces persistent inflammation and improves functional joint prognosis in adult patients with acute septic arthritis. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2026-02-27 |
| 6 | A Multicenter, Open-label, Randomized, Active-controlled, Phase 2a Study to Evaluate The Pharmacokinetics and Safety of Alpibectir/Ethionamide in Combination With The Standard Regimen in Patients With Tuberculosis Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: AlpE is a novel drug combination under development for the treatment of TB, with several positive attributes for TBM, including rapid bactericidal activity. The current trial aims to assess the plasma and CSF PK, as well as the safety and tolerability of alpibectir and three doses of Eto in patients with newly diagnosed TBM. Additionally, it is attended to investigate the effect of AlpE on the PK and efficacy of DTG during the first month of antiretroviral treatment (ART) for Human Immunodeficiency Virus (HIV)-positive patients. |
BIOVERSYS AG | 2026-03-03 |
| 7 | Phase 2, Open-label Evaluation of Olorofim in Early Coccidioidal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research study is being conducted to learn more about the use of olorofim in Coccidioidal (Cocci) meningitis, a rare but serious fungal infection that affects the brain and spinal cord. The study is exploratory, meaning that early information is being gathered to better understand the effectiveness of olorofim in coccidioidal meningitis in its early stages. The study plans to enroll approximately 10 to 12 participants who have been recently diagnosed-within the last 4 to 8 weeks-and who do not have a ventriculoperitoneal (VP) shunt, … |
FARIBA DONOVAN; | 2026-02-04 |
| 8 | Evaluation of Cochlear Implantation in Unilateral or Asymmetric Hearing Loss in Children PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Today, unilateral hearing loss must be assessed and managed just as bilateral hearing loss is. It is recommended to consider the auditory difficulties caused by the loss of stereophonic hearing and to offer auditory rehabilitation as early as possible. Studies show that hearing devices can be effective in certain cases and for specific auditory modalities. The prognostic factors for successful hearing aid adaptation are linked to early intervention and the presence of residual hearing (using a BiCROS system). However, … |
NATHALIE LOUNDON; | 2026-03-27 |
| 9 | Synergistic Intervention of Minimally Invasive Surgery and Deferoxamine in Intracerebral Hemorrhage (SMAD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, open-label trial designed to evaluate the safety, feasibility, and efficacy of combining minimally invasive surgery (MIS) with intravenous deferoxamine (DFX) for the treatment of spontaneous intracerebral hemorrhage (ICH), compared to standard medical care. This trial represents the first investigation of a dual-modality approach in ICH, integrating mechanical clot evacuation with biochemical neuroprotection, with the goal of improving neurological outcomes. |
GURSANT S. ATWAL; | 2025-10-10 |
| 10 | Maladies Neurologiques Auto-immunes Et Secondaires À L’immunothérapie : Étude Des Mécanismes Immunologiques Et Recherche Des Cibles De L’Attaque Immune PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The pathophysiology of neurological toxicities secondary to immune checkpoint inhibitors (ICIs) is unknown. Various mechanisms have been proposed: activation of cytotoxic CD8 T cells, autoantibodies via activation of B cells and CD4 cells, non-specific inflammation through the production of pro-inflammatory cytokines, and complement activation. The aim of this research is to characterise the pathophysiological mechanisms of neurotoxicities in cancer patients treated with ICIs. |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2026-03-06 |
| 11 | A PHASE 2 NOVEL ANTIMICROBIAL COMBINATION THERAPY TO TREAT TUBERCULOUS MENINGITIS PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This two-stage study will compare consented research participants with tuberculous meningitis receiving BPaLMZ to controls receiving SOC of rifampicin (R), isoniazid (H), pyrazinamide (Z), and ethambutol (E), known as RHZE. |
DAVID BOULWARE; | 2025-11-13 |
| 12 | Cerebrospinal Fluid Leak Incidence, Management and Risk Factor After Supratentorial Craniotomy for Intracranial Tumors: A Prospective Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebrospinal fluid is a clear fluid that surrounds and protects the brain. During surgery for brain tumors, neurosurgeons often need to open the covering of the brain (the dura) to reach the tumor. At the end of the operation, this covering is carefully closed again. In some cases, the closure might not be completely adequate leading to cerebrospinal fluid leak. This leakage may collect under the scalp or flow out through the surgical wound. When this happens, the surgical wound may not heal properly, … |
MEDICAL UNIVERSITY OF WARSAW | 2026-02-17 |
| 13 | A Phase 2b Randomised Placebo Controlled Trial of Valganciclovir for Cytomegalovirus Viraemia in Adults and Adolescents With Advanced HIV Disease PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if valganciclovir works to treat cytomegalovirus (CMV) infection in people with advanced HIV disease. It will also look at the safety of valganciclovir and how the body handles the drug. The main questions this study aims to answer are: Does valganciclovir safely lower the amount of CMV virus in the blood of people with advanced HIV disease? What medical problems or side effects do participants have when taking valganciclovir? Researchers will compare valganciclovir to a placebo (a look-alike tablet that does not contain any active drug) to see if valganciclovir works better than no treatment for CMV. Who can take part Adults and adolescents (15 years and older) who: Are living with HIV Have a CD4 count of 100 or less (meaning their immune system is very weak) Have CMV detected in their blood People who are pregnant, breastfeeding, very unwell, or have certain blood or kidney problems cannot take part. What will happen in the study Participants will: Be randomly assigned (like flipping a coin) to take either valganciclovir 900 mg or a placebo once a day for 4 weeks Continue to receive standard medical care for HIV and any other infections Be followed for 12 weeks after starting the study treatment During this time, participants will: Have blood tests to check CMV, HIV, and general health Have regular medical check-ups (daily in hospital, then at weeks 1, 2, 3, 4, 8, and 12) Be monitored closely for side effects, such as low blood counts or kidney problems Why this study is important Even though HIV treatment is widely available, many people still come to hospital with advanced HIV disease. In this group, about one in five people die despite starting antiretroviral therapy (ART). Reactivation of CMV is very common in these patients and has been linked to a higher risk of death. Valganciclovir is a medicine that stops CMV from multiplying. If it proves to be safe and effective in this study, it could become part of routine care to help reduce deaths in people with advanced HIV disease. Study design Type: Phase 2b, double-blind, randomised, placebo-controlled trial Sites: Helen Joseph Hospital (South Africa) and Mulago National Referral Hospital (Uganda) Number of participants: 150 (130 in the main trial, 20 in a smaller sub-study) Duration: Each participant will be followed for 12 weeks; total study duration about 2 years Possible risks and benefits Risks: Valganciclovir can cause low white blood cells, anaemia, or low platelets. These effects will be checked for regularly, and treatment will be stopped if unsafe levels are found. Benefits: The study may or may not directly benefit participants. However, it could provide important information that helps improve care for people with advanced HIV disease in the future. Oversight and safety The study is being conducted by researchers in Uganda, South Africa, the UK, and the USA, and follows international Good Clinical Practice (GCP) guidelines. An independent Data Safety and Monitoring Committee (DSMC) will regularly review safety information to protect participants. |
WITS HEALTH CONSORTIUM PTY | 2026-01-30 |
| 14 | Zilucoplan Treatment of Severe MG Exacerbations Leading to Hospitalization of Participants With Acetylcholine Receptor Antibody Positive GMG PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label, multicenter, interventional phase 3b study in participants with AChR+ gMG and severe exacerbation that require hospitalization. Patients will receive subcutaneous zilucoplan injections daily for 12 weeks. Participation in the study will last for approximately 18 weeks. |
MIRIAM FREIMER; | 2026-02-23 |
| 15 | A Phase I/II Clinical Study of Sacituzumab Govitecan Combined With Intrathecal Chemotherapy for The Treatment of Leptomeningeal Metastases From Her2-negative Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Leptomeningeal metastases (LM) is a lethal complication of malignant tumors, characterized by tumor cell invasion and proliferation within the subarachnoid space. LM from HER2-negative breast cancer remains challenging to treat, with a median overall survival of only 3-6 months despite aggressive therapy. This open-label, uncontrolled Phase I/II clinical study aims to evaluate the safety, feasibility, and potential efficacy of Sacituzumab Govitecan in combination with intrathecal pemetrexed chemotherapy for LM from HER2-negative breast cancer, with the objective of identifying a more effective treatment strategy. |
ZHENYU PAN; | 2025-09-29 |
| 16 | Neurological Manifestations in Children Diagnosed With Inflammatory Bowel Disease in Assiut University Child Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: screen for neurologic and psychiatric disorders in children and adolescents with IBD. |
BISHOY SHEHATA FAHIM; | 2025-11-25 |
| 17 | A Randomized, Partially Blinded, Dose-Exploratory, Active/Placebo-Controlled Phase I Clinical Trial Evaluating The Safety and Immunogenicity of The Adsorbed Acellular Pertussis (Tricomponent) DPT-Hib (Conjugate)-ACYW135-Group B Meningococcal (Conjugate) Combined Vaccine in Individuals Aged 2 Months to 6 Years PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This clinical trial is conducted in two parts. Part One employs a randomized, partially blinded, dose-escalation, partially active-controlled design. Part Two utilizes a randomized, blinded, placebo-controlled design. Part One is divided into four stages based on age and vaccine dose levels. Part Two consists of the 2-month-old vaccine/placebo groups. |
YANXIA WANG; | 2025-12-31 |
| 18 | Open-label, Multicentre, Tolerability, Safety and Pharmacokinetics Study of The Medicinal Product BP-SCIG 20% (Human Normal Immunoglobulin for Subcutaneous Administration) Manufactured By BIOPHARMA PLASMA LLC, Followed By An Efficacy Assessment of Long-term Use in Patients With Primary Immunodeficiency (PID) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: All patients will receive the investigational medicinal product BP-SCIG 20%, solution for subcutaneous administration, manufactured by BIOPHARMA PLASMA LLC. A loading dose of IMP may be required (at the Investigator’s decision): at least 0.2-0.5 g/kg (1.0-2.5 mL/kg) of body weight. This dose is distributed across several days, with a maximum daily dose of 0.1 to 0.15 g/kg. After achieving a steady-state (minimal) level of IgG, maintenance doses are administered at repeated intervals (approximately once a week) to achieve a cumulative monthly dose of 0.4-0.8 g/kg. |
BIOPHARMA PLASMA | 2026-01-16 |
| 19 | Lifestyle Intervention to Improve Twin Pregnancy Outcomes: An Integrated Pilot Study for A Multicentric Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial to is assess the benefits of holistic lifestyle interventions, including nutrition, physical activities, and mindfulness, aiming to reduce preterm birth in twins, potentially revolutionizing twin care globally. An initial integrated pilot study is be conducted to assess and refine the intervention methods. The primary objective of the pilot study is to evaluate feasibility. If deemed feasible, the full study will be implemented, … |
JACQUES JANI; | 2025-12-16 |
| 20 | Febrile Infants Swedish Study PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Approximately one million febrile infants aged ≤60 days present annually to pediatric emergency departments (PEDs) in Europe and the United States. Although fewer than 5% are diagnosed with meningitis or bacteremia (invasive bacterial infections – IBIs), and 10-15% with urinary tract infections (UTIs), current guidelines recommend extensive diagnostic evaluations, hospitalization, and empirical treatment with broad-spectrum parenteral antibiotics. This approach may contribute to medical overuse, with implications for patient care, healthcare resource utilization, … |
ORFANOS IOANNIS; | 2026-04-02 |
| 21 | Viral Infections of The Central Nervous System: Diagnosis and Clinical Outcome PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Central Nervous System (CNS) infections are caused by bacteria, viruses, fungi, helminths, with several clinical aspects. Studies in the literature generally focus on a single patient type, and no experiences have been reported in which immunosuppressed and immunocompetent adult and pediatric patients were simultaneously examined. Our study will include all possible patient types (immunocompetent adults, immunocompetent pediatric patients, and subjects immunosuppressed by co-softness), … |
LILIANA GABRIELLI; | 2026-01-22 |
| 22 | Utility of Optic Nerve Ultrasonography in Assessing Cerebral Inflammation and Intracranial Hypertension in Patients With Cerebral Impairment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Timely detection of signs of raised intracranial pressure or persistent inflammation within the meninges can expedite therapeutic decisions improving the prognosis of patients with brain damage. Optic nerve ultrasonography provides a user-friendly, safe, low-cost, and non-invasive imaging method that can be easily deployed for ICU patient assessment. This study aims to evaluate the sensitivity and specificity of optic nerve ultrasound in estimating cerebral inflammation extension and cerebral edema in patients in the ICU. The working hypothesis is that optic nerve ultrasound is a useful tool in the rapid diagnosis of cerebral edema and the presence or persistence of cerebral inflammation, … |
BOGDAN PAVEL; | 2026-01-12 |
| 23 | International Registry of Dengue Infection in Congenital Bleeding Disorders (DengueCBDR) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Dengue fever, a viral infection transmitted by Aedes mosquitoes, is a major health issue in tropical and subtropical regions. Around 20-30% of symptomatic patients developed Dengue Hemorrhagic Fever (DHF), which leads to impaired hemostasis, subsequently increasing the risk of bleeding. The hemostatic abnormalities associated with dengue infection included vascular permeability, platelet dysfunction, and coagulation defects. Therefore, Individuals with underlying bleeding disorders are at increased risk of bleeding. Dengue infection in patients with hemophilia was reported, … |
NONGNUCH SIRACHAINAN; | 2026-02-17 |
| 24 | Immunogenicity of A Single Dose of MenB-FHbp or MenACWY-TT/MenB-FHbp in MenB-4C Primed Young Adults PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine the immunogenicity of certain vaccines in protecting against meningitis B (MenB) in young adults who have previously received a different MenB vaccine. The main questions it aims to answer are: * How many participants are protected against four key types of MenB bacteria before and after getting the new vaccine? * How strong is the immune response after vaccination, and how many people show a noticeable boost in immune response? |
CHRISTINA ROSTAD; | 2025-12-22 |
| 25 | Testing A Biometric Identification System to Improve Malaria Vaccine Completion PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Receiving all four doses of the malaria vaccine can significantly protect children against malaria illness, hospitalization, and death. However, in Ghana, only 46% of children complete the full vaccination sequence. More broadly, many children in Ghana do not receive the full set of recommended pediatric vaccinations. To address this, Simprints, in collaboration with Ghana Health Services, will implement a digital vaccination record system linked to biometrics. This system will automatically identify children who are behind on their vaccination schedule, providing health workers with information to prioritize community outreach. Additionally, … |
ELISA MARIA MAFFIOLI; | 2025-12-03 |
| 26 | Dolutegravir Plus Lamivudine (DTG/3TC) Dual Therapy Versus Dolutegravir With TDF-lamivudine (DTG + TDF/3TC) Among Antiretroviral Naïve People With HIV and TB Receiving Rifampin-based TB Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This will be a Phase IIIb Clinical Trial, an international multicenter, randomized, three-arm, non-comparative trial of efficacy, safety, and tolerability of the dual therapy regimen dolutegravir plus lamivudine either twice daily or DTG/3TC ( Dovato) in the morning +dolutegravir (DTG) in the evening, versus standard of care (SOC) twice-daily dolutegravir plus 2 once-daily Nucleoside reverse-transcriptase inhibitors (NRTIs) tenofovir disoproxil fumarate /lamivudine (TDF/3TC), among antiretroviral therapy (ART)-nave individuals with HIV-1 receiving rifampin-based TB therapy |
ETHEL M WELD; | 2025-09-24 |
| 27 | Preterm Rupture of Membranes Optimising Antibiotics Trial (PROMOAT). A Pregnancy Domain Within PLATIPUS PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn which antibiotic regimen works best to prevent infection in pregnant women whose waters break early (preterm, pre-labour rupture of membranes, … |
CLARE WHITEHEAD; | 2025-04-02 |
| 28 | Glioma Intraoperative MicroElectroCorticoGraphy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to validate the safety and to assess the quality of the signals provided by newly developed micro ElectroCorticoGraphy electrodes, provided by the company Panaxium, based on conductive polymers (PEDOT:PSS) in patients suffering of gliomas during resection surgery performed in awake condition. The main questions it aims to answer are: * Safety of PEDOT:PSS microECoGs by assessing the rate of serious adverse events associated with their use during glioma surgery. * Quality of PEDOT:PSS microECoGs recordings, as compared with recordings with traditional macroelectrodes, assessed by signal-to-noise ratio, impedance, … |
GILLES HUBERFELD; | 2025-03-12 |
| 29 | The NoSeal Trial – Nasal Outcome Study Evaluating Artificial Leak-Sealing: A Prospective, Randomized, Controlled, Single-Blinded, Single-Center Clinical Trial Comparing Fibrin Glue (Tisseel®) and A Two-Component Synthetic Polymer Sealant (PEI/PEG, Adherus®) Versus No Sealant for The Prevention of Cerebrospinal Fluid Leak and Promotion of Wound Healing Following Endonasal Skull Base Surgery, Designed in Accordance With The SPIRIT 2025 Guidelines PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Postoperative cerebrospinal fluid (CSF) leak is a significant complication of endoscopic endonasal approaches (EEA) to the skull base. The use of tissue sealants such as fibrin glue (Tisseel) or synthetic agents (PEI/PEG) is widespread in surgical practice, however, recent high-quality evidence challenges their clinical benefit and cost-effectiveness. This study aims to investigate whether the routine use of sealants in patient with peri-operatively assessed low CSF leak risk, significantly improves outcomes over no sealant use, to guide more cost- effective, evidence-based closure strategies. To the best of our knowledge, … |
WOJCIECH CZYŻEWSKI; | 2025-10-14 |
| 30 | V-IMMUNE® for Primary Immunodeficiency: A Phase III Clinical Trial (VIP Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase III, non-randomized clinical trial (VIP Study) designed to assess the safety and efficacy of V-IMMUNE®, a 5% human normal immunoglobulin preparation, in approximately 50 patients with primary immunodeficiency (PID). Participants, all aged ≥2 years and already receiving IVIG therapy, will be switched to V-IMMUNE® at a dose of 600 mg/kg every three weeks via intravenous infusion. The study will use historical data as a control and extend over 12 months, … |
DEWTON MORAES VASCONCELOS; | 2026-01-20 |
| 31 | A Prospective, Blinded, Randomised Clinical Trial of Fludrocortisone Compared With Placebo in Critically Ill Patients Presenting With Aneurysmal Subarachnoid Haemorrhage PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: A multi-centre, prospective, blinded, randomised clinical trial of fludrocortisone compared with placebo in patients presenting with aneurysmal subarachnoid haemorrhage. The study aim is to determine if early administration of enteral fludrocortisone in aneurysmal subarachnoid haemorrhage reduce death and dependency at six months. |
JEREMY COHEN; | 2025-12-16 |
| 32 | Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Children Meningitis PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Prospective, multicenter, observational clinical registry of pediatric patients with acute infectious meningitis across approximately 20 public and private hospitals in Brazil. The study will include children under 18 years of age with suspected acute infectious meningitis. Data will be collected during hospitalization and post-discharge to evaluate clinical management, treatment and short and long-term outcomes. The study aims to generate real-world evidence on current practices and outcomes to support improvements in national care protocols. |
ANNA M GOMES; | 2025-07-14 |
| 33 | Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Adults Meningitis PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Prospective, multicenter, observational clinical registry of adult patients with acute infectious meningitis across approximately 30 public and private hospitals in Brazil. The study will include adults, 18 years old and older, with suspected acute infectious meningitis. Data will be collected during hospitalization and post-discharge to evaluate clinical management, treatment and short and long-term outcomes. The study aims to generate real-world evidence on current practices and outcomes to support improvements in national care protocols. |
ANNA M GOMES; | 2025-06-18 |
| 34 | Investigation of The Role of Inflammatory Markers in The Early Detection of Cerebral Vasospasm, Delayed Cerebral Ischemia, and Meningitis Associated With External Cerebrospinal Fluid Drainage After Non-Traumatic Subarachnoid Hemorrhage – A Prospective Case-Control Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Background Non-traumatic subarachnoid haemorrhage (SAH) is frequently complicated by delayed cerebral ischaemia (DCI) and by ventriculitis/meningitis when external CSF drains are used; bedside TCCD has limited accuracy for vasospasm detection, creating a need for early biomarkers. Objective To assess the predictive and diagnostic performance of IL-6, IL-1β, TNFα, procalcitonin (PCT), C-reactive protein (CRP) and adrenomedullin (ADM) measured in CSF and serum for vasospasm, DCI, and drain-associated ventriculitis/meningitis after SAH; to test whether combining biomarkers improves accuracy versus routine parameters; … |
TAMAS VEGH; | 2025-08-19 |
| 35 | Ultra-early Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia: Feasibility and Potential Benefit PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate the feasibility and potential benefit of Gamma Knife stereotactic radiosurgery (GK-SRS) as an ultra-early treatment option for trigeminal neuralgia (TN). The main questions it aims to answer are: 1. will earlier GK-SRS provide more durable pain relief compared to later GK-SRS? 2. will earlier GK-SRS reduce or eliminate the need for high-dose medical therapy? 3. will earlier GK-SRS have a lower risk of serious complications compared to other first-line treatments? If participants are assigned to GK-SRS treatment group, they will be asked to: • Undergo a preoperative MRI, … |
TEJAS SANKAR; | 2025-11-18 |
| 36 | V-IMMUNE® for Immune Thrombocytopenia: A Prospective Multicenter Study to Evaluate The Efficacy and Safety of Human Immunoglobulin in Adult and Pediatric Participants With Immune Thrombocytopenia. TIP Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, prospective clinical trial evaluating the efficacy and safety of V-IMMUNE®, a 5% human normal immunoglobulin formulation administered intravenously, for the treatment of immune thrombocytopenia (ITP) in patients aged ≥1 year. The primary objective is to assess the proportion of patients achieving a platelet count ≥50,000/mm³ on or before Day 9 following the first infusion. The trial employs a single-group design, comparing outcomes to historical controls derived from the literature. Eligible patients must have a confirmed diagnosis of ITP with a platelet count ≤20,000/mm³ and no concurrent conditions likely to cause thrombocytopenia. Key exclusions include non-immune thrombocytopenia, … |
SANDRA REGINA LOGGETTO; | 2026-01-20 |
| 37 | Efficacy Of Erythromycin Phonophoresis on Chronic Rhinosinusitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to evaluate the therapeutic effect of erythromycin phonophoresis in reducing chronic rhinosinusitis. |
NAHLA MAHMOUD MOHAMED ELKASSAS; | 2025-07-14 |
| 38 | Limited Versus Extended Trophic Feeding (LET-FEED) Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Study Hypothesis/Question In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis (LOS) without increasing the risk of other adverse outcomes. Study Design Type This is a multi-center, open-label, parallel-group, individual randomized controlled trial comparing two different trophic feeding regimens in preterm infants born between 25w0d and 31w6d. These infants will be randomly assigned to either the intervention group, receiving limited trophic feeding (20 to 25 mL/kg/day for one day) or the control group, … |
GREGORY C. VALENTINE; | 2025-07-28 |
| 39 | Unravelling The Measles Paradox: A Disease Associated With Both Immune Suppression and Immune Activation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The measles (MeV) paradox refers to an apparent contradiction: natural measles causes a transient but profound immune suppression putting patients at risk for opportunistic infections for years, while at the same time MeV infection induces robust immune activation leading to lifelong protection against measles. In this protocol, we test our hypothesis that natural measles causes immune amnesia by altering the composition of circulating immune memory cells. In comparison to the prior studies performed during the 2013 outbreak, we will specifically determine \[1\] to what extent pre-existing immunity is reduced, \[2\] for how long this functional immune suppression can be detected, … |
CORINE GEURTS VAN KESSEL; | 2025-12-05 |
| 40 | Are Developmentally At Risky Babies Environmentally Disadvantaged? PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A study conducted on infants aged between 3 and 11 months revealed a positive relationship between the home environment and developmental outcomes. Similarly, another study found that variability in motor and cognitive development could be better explained by environmental factors and parental knowledge and practices. It has also been shown that the opportunities provided in the home environment of preterm infants may be associated with motor development and sensory processing skills. In the literature, it is generally observed that studies evaluate either term infants or both preterm and term infants together. In the present study, however, … |
SEDA AYAZ TAŞ; | 2025-07-14 |
| 41 | Platform Trial For Cryptococcal Meningitis PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Cryptococcal meningitis is a fungal infection that causes a severe syndrome of meningitis that is 100% fatal without antifungal therapy. Even with antifungal therapy, mortality rates remain high, especially in low and middle income countries where the ongoing HIV/AIDS pandemic increases the risk of cryptococcosis among persons living with HIV infection. The combination of amphotericin and flucytosine (5-FC) has been the mainstay of therapy for the initial management of cryptococcal meningitis for 4 decades. Indeed, the effective delivery of these first line therapy in Africa can lower mortality to 25%. However, several challenges exist. First, … |
DAVID R BOULWARE; | 2026-01-07 |
| 42 | Cardiac Manifestations of Sepsis and Its Association With Disease Outcome: A Prospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective cohort study aims to investigate the cardiac manifestations of sepsis and their influence on disease outcomes among adult patients at Jimma University Medical Center, Ethiopia, from May 2025 to May 2026. The research will include adults aged 18 and older with sepsis, categorizing them based on the presence or absence of cardiac involvement, which will be assessed through clinical symptoms, biomarkers, ECG, and echocardiographic findings. The study will evaluate the persistence of cardiac abnormalities, functional capacity, and survival over one year, utilizing structured data collection and advanced statistical methods, including survival analysis and regression techniques, … |
KEDIR NEGESSO TUKENI; | 2025-07-23 |
| 43 | Bacteriological Profile and Antibiotic Sensitivity in Neonatal Intensive Care Unit At Assuit University Children Hospital PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to assess the bacteriological profile and antibiotic sensitivity in NICU of pediatric hospital of assuit university. |
MADLEEN THABET HOFNI BASALI; | 2025-03-25 |
| 44 | Causes of Secondary and Prolonged Fever During Treatment of Bacterial Meningitis and Viral Encephalitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the present study is to investigate causes of secondary and prolonged fever during treatment of viral encephalitis and bacterial meningitis in children aged from one month to 18 years . |
KEROLOS ATEF SHAFEEK TANIOUS; | 2025-05-14 |
| 45 | Risk Factors , Types and Neuroimaging Findings in Patients With Cerebral Palsy at Assiut University Children’s Hospital PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebral palsy (CP) is the most common motor disorder among children as its worldwide prevalence is ranging from 1.5 to more than 4 per 1000 live births or children of a defined age range. * Pediatric cerebral palsy is a clinical syndrome caused by brain injury or lesions in children from before birth to 1 month after birth, and mainly manifests as non progressive central dyskinesia and abnormal posture. * Research has shown that the prevalence of cerebral palsy in children worldwide is about 3.16% , … |
ASSIUT UNIVERSITY | 2025-04-15 |
| 46 | Seven Day Versus Fourteen-day Corticosteroid in Patients With Severe Alcohol -Associated Hepatitis- A Double Blind Randomized Controlled Trail (STASH II) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Alcohol-associated hepatitis (AAH) is one of the most severe manifestations of the spectrum of alcohol related liver disease (ARLD), with high morbidity and mortality. Currently, corticosteroids are the standard of care for patients with severe AAH, but no consensus exists on the dosing schedule of steroids. The investigators have recently demonstrated that tapering prednisolone over 4 weeks reduces the risk of infections at day 90. However, the investigators wanted to test whether the reduction in the duration of therapy would provide a similar benefit as tapering the dose of prednisolone. Therefore, … |
ANAND KULKARNI; | 2025-04-17 |
| 47 | An Observational, Prospective and Retrospective Clinical Study to Evaluate The Performance of QIAstat-Dx® Meningitis/Encephalitis (ME) Panel Plus During Normal Conditions of Use PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Performance evaluation of QIAstat-Dx® ME Panel Plus using the QIAstat-Dx® Analyzer to demonstrate that the QIAstat-Dx® ME Panel Plus achieves its intended performance during normal conditions of use by the intended user in the intended environment |
SARAH JOHNSON; | 2026-03-10 |
| 48 | Comprehensive Outcomes Monitoring for Peri- and Postnatal Invasive Group B Strep Sequelae (COMPPASS) Registry PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this registry is to collect and store important medical and non-health information on children from 0 to 18 years of age affected by early- (up to 24 hours after birth) and late-onset (up to 90 days after birth) invasive Group B Streptococcus (iGBS) and their families. Data collected from families of children affected by perinatal iGBS will support further research to understand the short- … |
DONNA RUSSELL; | 2025-03-26 |
| 49 | A National Multicenter Epidemiological Investigation of Small Vulnerable Newborns in China PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this nationwide multicenter observational study is to comprehensively investigate the severity of Small Vulnerable Newborns (SVN) issues across China and to propose further preventive and intervention measures. The primary aim is to provide a thorough description of SVN problems using a unified definition and framework, and to develop targeted prevention strategies. Participating centers across the country will collect clinical data on vulnerable newborns under their care and complete detailed questionnaires to support this research. |
XINHUA HOSPITAL SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE | 2025-08-27 |
| 50 | The Effect of Distraction With The Help of Virtual Reality on Pain, Anxiety and Vital Signs in Patients Undergoing Lumbar Puncture PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Lumbar puncture (LP) is one of the most frequently applied interventional procedures in the clinical field. It is still used as the gold standard diagnostic tool in some infectious and non-infectious diseases. Its use in treatment also increases the clinical importance of lumbar puncture . Due to its wide range of indications, … |
NAZAN TASAN; | 2025-07-01 |
| 51 | A Phase I/II Clinical Study of Intrathecal Combination Therapy With The PD-1/VEGF Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Leptomeningeal metastasis, characterized by tumor cells infiltrating and proliferating in the subarachnoid space, represents a distinct pattern of central nervous system involvement and is a fatal complication of malignant tumors. This phase I/II study is to evaluate the recommended dose, safety, feasibility, and therapeutic response of intrathecal PD-1/VEGF bispecific antibody plus pemetrexed in patients with leptomeningeal metastasis. |
ZHENYU PAN; | 2025-05-20 |
| 52 | Intrathecal Administration of Dual Checkpoint Inhibitor in Combination With Pemetrexed in Patients With Leptomeningeal Metastasis: A Phase I/II Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This phase I/II study is to evaluate the recommended dose, safety, feasibility, and therapeutic response of intrathecal dual checkpoint inhibitor (targeting PD-1 and CTLA-4 with QL1706) in combination with pemetrexed in patients with leptomeningeal metastasis. |
ZHENYU PAN; | 2025-05-15 |
| 53 | A Follow-up Trial to Assess The Persistence of The Immune Response to The Group B Streptococcus Vaccine (GBS-NN/NN2) After A Primary Vaccination of Healthy Pregnant Women, and to Assess Safety, Reactogenicity, and Immunogenicity of The GBS-NN/NN2 Vaccine When Administered During Follow-Up As A 1 Booster Dose During A New Pregnancy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The main objective of the study is to evaluate the persistence of the immunoglobulin G (IgG) antibody responses, specific to Alpha-like protein CN (AlpCN), Ribosomal Protein N (RibN), Alpha-like protein 1N (Alp1N), and Alpha-like protein 2 and 3 (Alp2-3N), after a primary vaccination with GBS-NN/NN2 in all participants. |
MINERVAX APS | 2026-01-30 |
| 54 | Intrathecal Administration of PD-1/CTLA-4 Bispecific Antibody Plus Pemetrexed in Patients With Leptomeningeal Metastasis From Solid Tumors: A Phase I/II Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Leptomeningeal metastasis, characterized by tumor cells infiltrating and proliferating in the subarachnoid space, represents a distinct pattern of central nervous system involvement and is a fatal complication of malignant tumors. This phase I/II study is to evaluate the recommended dose, safety, feasibility, and therapeutic response of intrathecal Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) bispecific antibodies combined with pemetrexed in patients with leptomeningeal metastasis. |
ZHENYU PAN; | 2025-05-20 |
| 55 | Nursing Strategies to Increase Vaccination Rates in Adolescents: Education, Video Animation and Games PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Purpose: This study aims to evaluate how immunization education, video animation, and game interventions based on the Health Belief Model (HBM) affect the immunization decisions of late adolescents. The findings could contribute to the development of targeted interventions to increase vaccine acceptance among adolescents. Hypotheses: Does the educational intervention, video animation, and game application affect adolescents’ knowledge of vaccines? Do these interventions influence adolescents’ positive attitudes towards vaccines? Will the interventions lead to significant changes in adolescents’ health beliefs, especially regarding perceived risks, benefits, … |
HAKAN AVAN; | 2025-02-18 |
| 56 | Molecular Epidemiology of Enteroviruses Detected at The Virology Laboratory of Brest University Hospital During The Period 2018-2024: Retrospective Analysis of An Atypical Meningitis Epidemic in 2024 PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is being done to learn more about enterovirus infections detected in the cerebrospinal fluid of patients at CHU de Brest. Researchers will analyze medical records and laboratory data collected between 2018 and 2024. They will look at how these infections present in patients, and whether a specific virus type, called Echo-9, may be associated with different clinical features or represent an emerging variant. |
UNIVERSITY HOSPITAL BREST | 2025-04-10 |
| 57 | Neonatal Comfort Seat Allowing Safe Lumbar Puncture and Minimizing Failure: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A research trial which compares standard of care against employing a novel device for immobilization of babies undergoing upright LP, the present working name for the device is LP Comfort Seat (LPCS). The research question is: P: In late-preterm to term babies who are 0-28 days and undergoing LP for R/O Sepsis I: Is the LPCS more effective C: Than human/RN assisted upright positioning O: In generating a higher rate of first attempt LP success Primary outcome measure is first attempt LP success (any evidence of CSF which is diagnostically useful by content and volume) Secondary outcome measures could include 1. A qualitatively unadulterated tap (no blood) although as you know this is hard to control even with perfect positioning and technique and single pass 2. A difference in FLACC score as measure of overall pain/comfort between test and control |
JOEL COX; | 2025-02-06 |
| 58 | Post-marketing Database Survey: A Cohort Study to Evaluate The Safety of Cuvitru in Patients With Primary Immunodeficiency Using The PIDJ2 (Primary Immunodeficiency Database in Japan) Registry PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a retrospective database study in Japan to evaluate the safety of Immune Globulin Subcutaneous (Human), 20% Solution in participants with primary immunodeficiency disease (PID). This survey will conduct in use of medical database called PIDJ2. |
TAKEDA | 2026-02-20 |
| 59 | A Phase I, Multicentre, Open-label, First-in-Human, Dose Escalation and Expansion Study of DM002 in Patients With Advanced Solid Tumors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of study： The study has two parts: Part 1 Dose Escalation and Part 2 Dose Expansion. In Part 1, a few participants will receive the lowest dose of study drug. The study team will make sure it is safe and tolerated before enrolling new participants at a higher dose of study drug. There will be up to six or more dose levels of study drug tested (called cohorts). Which dose you receive will depend on how many participants have taken part in the study before you. The purpose of Part 1 of the study is to evaluate the safety of the study drug at different dose levels, to understand what your body does to the study drug, and to find the best dose of study drug in people who have advanced solid tumor cancers. In Part 2, participants will receive the best dose level that was determined in Part 1 of the study. The purpose of Part 2 of the study is to evaluate the safety of the study drug at the dose level determined in Part 1, to understand what your body does to the study drug, and to see how your cancer responds to the study drug. Participants will: Participants will have 17 or more visits to the study centre. This study has a screening phase of up to 28 days , and a treatment phase with cycles of 21 days each. Participants will also have an End of Treatment (EOT) visit 21 days after the final study drug treatment, and a Follow-up visit 30 days after the EOT visit . Participants will be contacted by telephone every 3 months after the Follow-up visit to check on the wellbeing and record any new anticancer therapy they may have started. |
XADCERA BIOPHARMACEUTICAL SUZHOU | 2026-01-15 |
| 60 | A Cluster-randomised, Open-label Trial to Compare The Impact of Combined Mass Vaccine and Drug Administrations, Mass Drug Administration, Mass Vaccinations, or No Intervention on Plasmodium Falciparum Malaria Transmission PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open i.e. not blinded, cluster-randomised, controlled intervention study. The study will use a factorial design to estimate the protective effectiveness of mass drug administrations, mass vaccinations, combined mass vaccinations and drug administrations versus the current standard of care. |
LORENZ VON SEIDLEIN; | 2025-12-18 |
| 61 | Diagnostic Significance of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis : A Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The TOTEM study is a single-center study designed to evaluate the performance of the D-lactate assay in cerebrospinal fluid (CSF) for the diagnosis of ventriculostomy-related nosocomial meningitis. The study will be conducted in the neurosurgical intensive care unit of the Toulouse University Hospital, in patients with a suspected diagnosis of ventriculostomy-related nosocomial meningitis. |
UNIVERSITY HOSPITAL TOULOUSE | 2025-12-31 |
| 62 | Parental Stress and Attachment in Premature Infants in Their First Months of Life in Early Months of Life in Child Development and Early Care Centres PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: Advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term. Furthermore, previous studies have linked prematurity, as an associated risk factor, with possible alterations in the bonding between the child and his or her mother in the first years of life. The possible impact that the stay in the neonatal unit may have on the mental health of the parents is noted. In fact, … |
JOSE MIGUEL SORIA LOPEZ; | 2025-02-07 |
| 63 | A Prospective, Randomised, Placebo-controlled, Double-blind First in Human Trial Evaluating The Safety and Immunogenicity of V-212 Administered on Three Occasions in Healthy Adult Volunteers PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Virometix AG, is conducting research into a vaccine (V-212) to prevent pneumococcal disease, which is any type of illness caused by infection with a bacterium called Streptococcus pneumoniae (S. pneumoniae). This trial is being conducted to obtain insight into the body’s immune response and possible adverse effects of the trial vaccine in healthy adult volunteers. Three different doses will be evaluated to identify an optimal dose for future trials. The trial is a prospective (collects data into the future), randomised, double-blind, phase I, first in human, … |
ISABEL LEROUX-ROELS; | 2025-08-26 |
| 64 | Prospective Ocular Imaging for Intracranial Pressure Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospectively recruiting, database development study collecting images and videos of the spontaneous venous pulsation at the back of people’s eyes – this is a pulse one can see on examination of the back of the eye, originating from the blood vessels around the nerve that connects the eye to the brain (the optic nerve), and is present in most people who have normal pressure around the brain. However, in people with raised pressure in the brain, this pulse disappears as the pressure rises. Many things can cause the pressure around the brain to increase, including tumours, … |
KING’S COLLEGE HOSPITAL NHS TRUST | 2025-03-03 |
| 65 | A Randomized, Blinded, Peer-controlled Clinical Trial to Evaluate The Safety and Immunogenicity of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 7-17 Year Olds PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, blinded, peer-controlled study. There will be 2 treatment groups, screened subjects were given study numbers in the order of enrollment and randomly assigned to the test and control groups in a 1:1 ratio. Subjects were required to complete a 1-dose immunization program with 0.5 ml of vaccine in both the test and control groups, afterwards some subjects entered the immune persistence group. |
ZHIQIANG XIE; | 2025-07-29 |
| 66 | ReMARk: A Multi-level Intervention Addressing Disparities in Rural HPV-related Cancer Prevention: Part 3- Evaluation PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: There are three main objectives of the protocol. First, we will evaluate the added clinical- and cost- effectiveness of parent-targeted motivational aids (reminder/recall and phone-based MI) alone and when combined with community-targeted healthcare access assistance beyond the effects of clinician-targeted training. Second, we will estimate the differential effectiveness of the implementation strategies by patient-level factors (age, race/ethnicity, sex, distance from home to clinic, social vulnerability). Third, we will measure moderation of implementation strategy effectiveness by clinic-level factors (HPV vaccination priority, resources, clinic visit types, scheduling practices, and implementation success). Within 11 rural North Central Florida counties, … |
STEPHANIE STARAS; | 2025-09-09 |
| 67 | A Phase 1, Multicenter, Open-label, First-in-human, Dose Escalation and Expansion Study of DM005 in Patients With Advanced Solid Tumors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to find out about the safety, efficacy, and tolerability of DM005 for patients with the advanced solid tumors. DM005 is an experimental drug which is not approved by health authorities for the treatment of advanced solid tumors. For each participant, there will be a screening period of up to 28 days, a treatment period consisting of 21-day cycles, an end of treatment (EOT) Visit (+7 days), … |
DOMA BIOPHARMACEUTICAL（SUZHOU）CO | 2026-01-15 |
| 68 | A Phase I, Multicenter, Open-label, First-in-Human, Dose Escalation and Expansion Study of DM001 in Patients With Advanced Solid Tumors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to find out about the safety, efficacy, and tolerability of DM001 for patients with the advanced solid tumors. DM001 is an experimental drug which is not approved by health authorities for the treatment of advanced solid tumors. Participants will have up to 17 visits during the study.There will be up to a 4-week Screening Period followed by a treatment period that will be divided into 3-week cycles/ Participants will have 5 study visits during Cycle 1, 3 visits during Cycles 2 and 3, … |
XADCERA BIOPHARMACEUTICAL SUZHOU | 2025-04-17 |
| 69 | NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Blood Flow in Infants PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates. For many years, the ultrasound group in Trondheim has been at the forefront in the development of new ultrasound technology for the diagnosis and monitoring of disease. Several methods previously developed in this research group are today widely used in hospitals around the world. In this project the investigators aim to test a new ultrasound technology that allows continuous monitoring of cerebral blood flow in sick neonates and pre-term children. This technology was CE-certified in October 2022, … |
SIRI ANN NYRNES; | 2025-03-25 |
| 70 | Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living With HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living with HIV: A Prospective, Individual, Double-Blind, Randomized Controlled Study is evaluating immediate or delayed single-dose nonavalent HPV vaccination among women living with HIV who received prior HPV vaccination. |
RUANNE BARNABAS; | 2026-01-12 |
| 71 | An Open-label Extension Study to Evaluate Rozanolixizumab in Pediatric Study Participants With Generalized Myasthenia Gravis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to assess the long term safety and tolerability of additional 6-week treatment cycles with rozanolixizumab in pediatric participants with generalized Myasthenia Gravis (gMG) aged ≥2 at the time of the Screening Visit of MG0006. |
UCB BIOPHARMA SRL | 2026-02-27 |
| 72 | Presepsin to Safely Reduce Antibiotics in Preterm Infants: A Randomized Controlled Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In the Netherlands, more than 85% of the preterm infants born \<32 weeks gestational age get antibiotics directly after birth because of the risk of infection with a bacteria. However, only 1 in 70 of these preterm babies actually has a bacterial infection. The use of antibiotics after birth can lead to problems on short term (bowel infection, infection with a bacteria later on or death) or long term (asthma, allergy, ... |
DOUWE VISSER; | 2025-10-02 |
| 73 | A Phase 1, First-in-human, Open-label Study to Evaluate The Safety, Tolerability, PK, and Preliminary Anti-tumor Activity of The Novel Oral CDK2 Degrader NKT3964 in Adults With Advanced/Metastatic Solid Tumors PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of the Dose Escalation phase of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity to determine the preliminary recommended dose for expansion (RDE) of NKT3964 in adults with advanced or metastatic solid tumors. The goal of the Expansion phase of the study is to evaluate the preliminary anti-tumor activity of NKT3964 at the RDE based on objective response rate (ORR) and determine the preliminary recommended Phase 2 dose (RP2D). |
MICHAEL BIRRER; | 2026-02-11 |
| 74 | Needle-Free Jet Injection Versus Traditional Lidocaine Needle Infiltration for Local Anesthesia in Infant Lumbar Puncture PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: We hypothesize that the J-Tip needle-free jet-injection system offers comparable pain control and greater provider satisfaction due to its less invasive nature compared to traditional needle infiltration of 1% lidocaine in infants undergoing lumbar punctures. Our aim is to evaluate the efficacy and feasibility of different local anesthetic techniques in the ED setting by comparing traditional lidocaine needle infiltration with J-tip. |
JAMIE LAUGHY; | 2025-08-01 |
| 75 | Infectious Complications Associated With The Use of Peri-partum Neuraxial Anaesthesia in Patients With Primary Immunodeficiencies PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate if neuraxial anesthesia (epidural or intradural anesthesia) used during childbirth is associated with more frequent infectious complications in patients with primary immunodeficiencies (PID). |
CAROLINE CHARLIER-WOERTHER; | 2025-09-12 |
| 76 | Early Interferon-beta Treatment for West-Nile Virus Infection PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: West Nile virus (WNV) is a mosquito-borne virus which in majority of cases causes only self-limited disease. Despite that, in minority of cases (~0.5%) it can infect the brain and cause severe and even life-threatening disease (neuroinvasive disease). Recent study has shown that up to 40% of WNV patients who develop neuroinvasive disease, have antibodies against Interferons (anti-Type I interferon autoantibodies), which neutralizes interferons, … |
TEL AVIV SOURASKY MEDICAL CENTER | 2025-12-31 |
| 77 | Evaluating The Feasibility of Utilizing A Novel Brain Activity Monitor in The Neurosciences Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the clinical utility of Neurosteer’s brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients. The research team will be conducting a single-site study. The research team will enroll 100 patients admitted to the NSICU. 50 of these patients will have Acute Neurological Injuries (ANI) and the other 50 will not have an ANI. All enrolled patients will receive the intervention, … |
NEHA DANGAYACH; | 2025-07-01 |
| 78 | Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs). Patients with EVDs were chosen as the target population because they frequently require prolonged admission to the intensive care unit and drainage of CSF in order to prevent hydrocephalus. The estimated sample size is 20 subjects. This is a prospective cohort of patients with SAH. Patients will be included if they have an in-dwelling EVD, … |
AARON COOK; | 2025-12-26 |
| 79 | Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors: A Phase I/II Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an open-label, single-arm, phase I/II trial of immune checkpoint inhibitor combined with pemetrexed intrathecal injection for leptomeningeal metastasis from solid tumors. |
ZHENYU PAN; | 2025-09-29 |
| 80 | An Open-label, Single-arm Study Evaluating The Activity, Safety, and Pharmacokinetics of Rozanolixizumab in Pediatric Study Participants With Moderate to Severe Generalized Myasthenia Gravis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to assess the safety and tolerability of subcutaneous (sc) administration of rozanolixizumab in pediatric participants aged ≥2 to \<18 years with generalized Myasthenia Gravis (gMG). |
UCB BIOPHARMA SRL | 2026-03-27 |
| 81 | Phase IV Clinical Study of The Safety of Menhycia® in 3-Month-Old Infants PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This study is an open, multicenter Phase IV clinical study to evaluate the safety of vaccination with Menhycia®. The study plan is to enroll approximately 3,000 infants at 3 months of age who have not been vaccinated with any epidemic encephalitis vaccine, and to administer a total of 3 doses of Menhycia®, with a minimum of 1 month between doses, and a booster dose of 1 dose of immunization is allowed at 12 months of age. |
CANSINO BIOLOGICS | 2025-08-15 |
| 82 | A Phase I Randomized, Observer-blind, Placebo-controlled Trial of A Haemophilus Influenzae Serotype A (Hia) Glycoconjugate Vaccine With Alum Adjuvant in Young Adults 18 to 40 Years of Age PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Haemophilus influenzae serotype a (Hia) has emerged as a leading cause of serious illness in Indigenous children in Canada and Alaska in recent decades. In hospital-based surveillance studies, Hia was the most common cause of invasive disease, resulting in morbidity or mortality after Haemophilus influenzae serotype b (Hib). Given the success of the Hib vaccine program and the pathophysiologic similarities between Hib and Hia, immunization is the obvious way to protect Indigenous children living in small and scattered communities. The Public Health Agency of Canada has been working with the National Research Council and other members of the Consortium, … |
BRIAN WARD; | 2025-04-30 |
| 83 | Effect of Music Therapy Applied During Lumbar Puncture on Infants’ Pain Perception: Randomized Controlled Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Bacterial meningitis is a serious infection that is more common in newborns is associated with significant morbidity and mortality. The gold standard for the diagnosis of bacterial meningitis is a positive cerebrospinal fluid (CSF) culture, usually obtained via lumbar puncture (LP). İnfants and children have similar physiological responses to pain as adults has led to greater emphasis on the assessment and management of pain in children. Therefore, … |
AYŞE METIN; | 2025-08-14 |
| 84 | NutriVax-Measles: Increasing Measles Vaccination Coverage Through Supplementation With An SQ-LNS Incentive in Children Aged 6-23 Months, A Pragmatic Parallel Cluster-randomized Controlled Trial in Yobe State, Northern Nigeria PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Provision of SQ-LNS also holds promise in incentivizing vaccination as well as other health services. The investigators will estimate 1) the effectiveness of a SQ-LNS mass supplementation program added to routine immunization program compared to routine immunization program alone in terms of measles vaccine coverage, after 12 months of program implementation, 1) in children aged 12-23 months in the end line cross-sectional household survey, 2) in children aged 6-12 months at inclusion, in a longitudinal 12 months follow-up survey. Secondary objectives are to assess the barriers and facilitators from the perspectives of parents/legal guardian of children, … |
RENAUD BECQUET; | 2026-03-10 |
| 85 | Evaluation of The Safety and Tolerability of 24-valent Pneumococcal Polysaccharide Conjugate Vaccine in Individuals Aged 18 Years and Above: A Random PhaseⅡClinical Trial PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In the treatment of pneumococcal diseases, the common use of penicillin-based antimicrobial agents has led to drug resistance, which has become a global challenge. Therefore, disease prevention through vaccination is essential. The 23-valent pneumococcal polysaccharide vaccine, the first widely used vaccine, has limitations. Subsequent pneumococcal polysaccharide conjugate vaccines have improved protection rates but increased cases of infections caused by non-vaccine serotype strains. Currently, … |
JIANGSU PROVINCE CENTERS FOR DISEASE CONTROL AND PREVENTION | 2025-06-24 |
| 86 | Multiparametric Molecular Panel Evaluation QIAstatDxMeningitis/Encephalitis for Diagnosis of Infections of The Central Nervosous System PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Infections involving the central nervous system (CNS), such as meningitis/encephalitis (ME), are serious clinical conditions associated with high morbidity and mortality rates, as well as significant long-term consequences. ME can be caused by a wide variety of pathogenic agents. Clinical symptoms may vary and it has been shown that early identification of the pathogens causing ME allows for timely and appropriate treatment, thus reducing permanent neurological damage. The multiparameter panel QIAstat-Dx®Meningitis/Encephalitis can detect in one hour on a sample of 15 bacterial, viral and fungal pathogens. In the diagnostic routine, … |
LILIANA GABRIELLI; | 2025-12-18 |
| 87 | Optimizing The Dose of Flucytosine for The Treatment of Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cryptococcal meningitis (CM) is a fungal infection that causes a severe syndrome of meningitis that is 100% fatal without antifungal therapy. Even with antifungal therapy, mortality rates remain high, especially in Africa where the ongoing HIV/AIDS pandemic leads to higher prevalence of cryptococcosis. Combination of amphotericin and flucytosine (5-FC) is the mainstay of therapy for the initial management of CM. Indeed, … |
DAVID B MEYA; | 2025-08-27 |
| 88 | Efficacy, Safety and Pharmacokinetics of Boya Intravenous Immunoglobulin (IVIG) in Participants With Primary Immunodeficiency PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the safety, efficacy and pharmacokinetic properties of Boya’s IVIG preparation in participants with PID aged less than 60 years and more than 6 years. |
AZIDUS BRASIL | 2025-09-30 |
| 89 | A Multicenter, Randomized, Double-blinded, Positive-controlled Phase Ⅲ Clinical Trial to Evaluate Lot-to-lot Consistency, Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, double-blinded, positive controlled study to evaluate the lot-to-lot consistency, immunogenicity and safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in adults aged 18 to 55 years. Subjects will be randomized to receive investigational Lot 1, Lot 2, Lot 3 vaccine or control vaccine in a 1:1:1:1 ratio, with the subjects in experimental group randomly and equally assigned to three different batches of MCV4 for single-dose vaccination. |
ISTI SUHARJANTI; | 2025-04-03 |
| 90 | Comparative Study Between Dexmedetomidine and Fentanyl As Adjuvants to Bupivacaine in Femero Sciatic Block for Below Knee Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post dural puncture headache, hematoma, and neurological deficit |
AIN SHAMS UNIVERSITY | 2025-03-07 |
| 91 | Évaluation Des Facteurs Pronostiques Et De L’évolution Des Mastoïdites Aigües Dans La Région Grand-Est PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: There is an increased incidence of acute mastoïditis and a lack of homogeneity in management. The investigator aim to refine the epidemiological knowledge on this pathology. Data of children with acute mastoiditis of the last ten years in five hospitals of the North-East of France (University Hospitals of Nancy, Strasbourg, Dijon, Besançon and the Regional Hospital of Metz-Thionville) will be analyzed. |
CÉCILE RUMEAU; | 2025-08-14 |
| 92 | A Randomized, Blinded, Peer-controlled Clinical Trial to Evaluate The Safety and Immunogenicity of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in A Population Aged 18-59 Years PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a randomized, observer-blind, peer-controlled study. There will be 2 treatment groups, screened subjects were given study numbers in the order of enrollment and randomly assigned to the test and control groups in a 1:1 ratio. Subjects were required to complete a 1-dose immunization program with 0.5 ml of vaccine in both the test and control groups. |
QING WANG; | 2025-07-29 |
| 93 | Factors Influencing The Mortality of Patients With Subarachnoid Haemorrhage in The Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Spontaneous subarachnoid haemorrhage (SAH) is a serious cerebrovascular disease with high morbidity and mortality.Determining the factors associated with mortality in the ICU follow-up and treatment of patients with spontaneous SAH is very important for clarifying these uncertainties and improving ICU outcomes.In the literature, there are very few studies analysing ICU mortality and mortality-related factors in this patient group.The aim of this study was to determine the demographic/clinical characteristics and factors affecting the mortality of spontaneous SAH patients admitted in the ICU. |
MELIKE CENGIZ; | 2024-06-15 |
| 94 | Bedside Ultrasound on The Effectiveness of Lumbar Puncture in Children – Open-label Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the study is to assess the influence of ultrasound examination of the lumbar spinal canal on the effectiveness of lumbar puncture. An open-label, randomized interventional study. |
AGATA ĆWIEK; | 2025-07-30 |
| 95 | A Feasibility Study of A Controlled Human Infection Model (CHIM) With Intradermal Bacillus Calmette-Guérin (BCG) Injection in Malawi PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Despite tremendous efforts, an effective tuberculosis (TB) vaccine remains elusive. TB continues to infect and kill many. In 2021, TB infected more than 10 million and killed 1.6 million people. To date, the M.bovis bacille Calmette Guerin (BCG) is the only licensed vaccine against tuberculosis (TB). Efforts to come up with new and effective vaccines have not been successful. Partially, the lack of suitable disease models and protection correlates hinders the research of new vaccines. Controlled human infection model studies (CHIM) involve administering disease-causing microbes to healthy individuals, … |
STEPHEN GORDON; | 2026-03-01 |
| 96 | Evaluation of The Levels of Calcitonin Gene-related Peptide and Substance P in Patients With Post-operative Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In cases of meningitis caused by external ventricular catheters (EVDs), which are the most commonly placed intracranial catheters that can lead to central nervous system infection through contamination/colonisation, the diagnosis may not be differentiated by either clinical signs and symptoms or conventional cerebrospinal fluid (CSF) tests. Therefore, due to the limitations in diagnosis and prognostic prediction of EVD-induced meningitis and the high mortality/morbidity rates of the disease, markers with high sensitivity and specificity in post-operative meningitis are needed. Calcitonin gene-related peptide (CGRP), a neuropeptide, … |
MELIKE CENGIZ; | 2025-08-30 |
| 97 | Drainage Fluid Biomarkers and Postoperative Gastrointestinal Dysfunction in Colorectal Surgery. A Monocentric Prospective Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Postoperative gastrointestinal dysfunction (POGD), often referred to as postoperative ileus (POI) after colorectal surgery, is characterized by symptoms such as nausea, vomiting, abdominal distension, and delayed bowel movements. The incidence of this issue varies among medical institutions, impacting patient nutrition, prolonging hospital stays, and increasing healthcare costs. The complex pathogenesis of POGD involves a brief neurogenic phase (within 3 hours) and a more prolonged inflammatory phase (beginning at 3-4 hours and lasting for days). The inflammatory phase is crucial and is recognized as initiated by mast cells and damage-associated molecular patterns that activate macrophages in the intestinal muscle layer. Subsequently, … |
CHAOYANG HOSPITAL OF CHINA MEDICAL UNIVERSITY | 2024-10-01 |
| 98 | Evaluation of Herpes Zoster Characteristics and Costs in Cancer Population PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Rationale. Cancer patients are more likely to develop herpes zoster (HZ) and its complications. An acute episode of HZ implies in postponement of current cancer treatments, hospitalization, high risk of development of postherpetic neuralgia and high costs for paying sources. A better understanding of disease incidence, hospitalization, development of postherpetic neuralgia, and costs generated for funding sources may increase awareness of the impact of vaccination on oncology population. Objectives. Obtain HZ incidence and percentage of hospitalization in study population according to cancer type, topography, … |
AC CAMARGO CANCER CENTER | 2024-12-30 |
| 99 | Phase II Clinical Study of Contezolid for The Treatment of Tuberculous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Contezolid is a novel oxazolidinone antibiotic developed by Shanghai Mengke Pharmaceutical Co., Ltd., which successfully went public in 2021. It inhibits bacterial growth by interfering with protein synthesis through its translational inhibitory effect on bacteria. Contezolid has demonstrated promising clinical results in patients with drug-resistant tuberculosis, making it a powerful tool in the fight against drug-resistant tuberculosis. Currently, there is a lack of pharmacokinetic data on contezolid in patients with central nervous system tuberculosis. Some studies have reported the steady-state concentrations of contezolid in the serum and cerebrospinal fluid (CSF) of tuberculous meningitis patients receiving multidrug therapy, … |
NIE WENJUAN; | 2025-02-06 |
| 100 | The Efficacy of High-frequency Short-time Spinal Cord Stimulation in The Treatment of Herpes Zoster-associated Neuralgia PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Zoster-associated neuralgia (ZAN) is a type of neuropathic pain caused by the reactivation of the varicella-zoster virus (VZV). The global annual incidence is approximately 3-5 per 1,000 individuals, and in China, the incidence is around 4.89 per 1,000 individuals, increasing with age. The underlying mechanisms of ZAN involve neuroinflammation, peripheral and central sensitization, and other factors, ultimately leading to anxiety, depression, and significant reductions in quality of life. Treating ZAN remains challenging. Spinal cord stimulation (SCS) alleviates pain via multiple mechanisms, including the gate control theory, modulation of neurotransmitters (e.g., gamma-aminobutyric acid), suppression of neuroinflammation (e.g., … |
LI ZHAO; | 2025-04-30 |
| 101 | Type of Surgical Intervention for Chiari Malformation-syringomyelia: A Multicenter Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine whether a posterior fossa decompression and duraplasty with or without tonsil manipulation results in better patient outcomes with fewer complications and improved quality of life in those who have Chiari malformation type I and syringomyelia. |
XUANWU HOSPITAL BEIJING | 2026-02-17 |
| 102 | Efficacy, Safety, and Pharmacokinetics of Shu Yang IVIG in Patients With Primary Immunodeficiency PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the safety, efficacy, and pharmacokinetic properties of Shu Yang intravenous immune globulin in patients with primary immune deficiency aged less than 60 years. The main benefit of IVIG is to help the body fight against a large variety of infections generally associated with morbidity and mortality in patients with primary immunodeficiency diseases, particularly in CVID and XLA. In addition, a decrease in the number of infections, a reduction in medications and hospitalizations, and a better quality of life are expected. Throughout treatment, … |
AZIDUS BRASIL | 2025-06-08 |
| 103 | Anticholinergic Burden As A Modifiable Risk Factor in Cardiac Surgery: Evidence From A Randomized Controlled Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Anticholinergic drugs are common in older adults and linked to cognitive decline, frailty, longer hospital stay, and higher mortality. This cumulative burden, often increased by anesthetics and analgesics, may worsen during surgery. The study evaluates whether reducing perioperative anticholinergic load improves recovery after cardiac surgery. |
MUHAMMED ÇOBAS; | 2026-02-24 |
| 104 | The Effect of Use of Infection Control Precaution Package on The Rate of SSI in Patients Undergoing Craniotomy PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Surgical site infections (SSI) are the most common complications after surgical operations and are in the top three in Healthcare Associated Infections (HIE). Due to surgical site infections, morbidity, mortality and hospital stay in postoperative patients increase, as well as the cost of treatment. The World Health Organization (WHO) has published a list of infection control measures, including preoperative, intraoperative and postoperative precautions, … |
BIRGÜL BELGIN; | 2024-08-31 |
| 105 | Phenobarbital Versus Levetiracetam Neonatal Convulsion PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: If the seizure is clinically evident and prolonged, the most common first-line agent utilized is phenobarbital.(Glass et al;2016) ,Its mechanism of action is the synaptic inhibition through an action on GABA receptors, It can not only control seizures but also reduce the metabolism of the brain .(Geneva;2011) ,Phenobarbital can control 43-80% of electrical seizures (abnormal electroencephalograms) in newborns.(Sharpe et al;2020) Levetiracetam can also be used for treatment of neonatal seizures, which is safer than phenobarbital, it’s mechanism of action is modulation of synaptic neurotransmitter release through binding to the synaptic vesicle protein SV2A in the brain, … |
NASHWA NASSER HESHMAT; | 2025-05-30 |
| 106 | A Phase II, Randomized, Open-Label Trial of A Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus A Standard Nine-Month Regimen for The Treatment of Adults and Adolescents With Tuberculous Meningitis: Improved Management With Antimicrobial AGents Isoniazid RifampiciN LinEzolid for TBM (IMAGINE-TBM) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC) treatment for tuberculosis meningitis (TBM). |
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES NIAID | 2025-12-02 |
| 107 | Morbidity, Mortality And Risk Factors of Mpox in HIV Negative High Risk Sexual Health Clinic Attenders and People Living With HIV PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This data collection study aims to describe and compare the outcomes of Mpox on people living with HIV (PLHIV) and HIV-negative individuals who are on pre-exposure prophylaxis (PrEP). The study also aims to identify risk factors for specific Mpox outcomes. |
NICOLO GIROMETTI; | 2025-08-13 |
| 108 | Evaluation of The Safety and Tolerability of 24-valent Pneumococcal Polysaccharide Conjugate Vaccine in Individuals Aged 18 Years and Above: A Random PhaseⅠClinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In the treatment of pneumococcal diseases, the common use of penicillin-based antimicrobial agents has led to drug resistance, which has become a global challenge. Therefore, disease prevention through vaccination is essential. The 23-valent pneumococcal polysaccharide vaccine, the first widely used vaccine, has limitations. Subsequent pneumococcal polysaccharide conjugate vaccines have improved protection rates but increased cases of infections caused by non-vaccine serotype strains. Currently, … |
JIANGSU PROVINCE CENTERS FOR DISEASE CONTROL AND PREVENTION | 2025-06-18 |
| 109 | A Multi-center Open-label Trial Evaluating The Efficacy and Safety of Daratumumab SC in Treatment of Patients With Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits (PGNMID) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research is to study the safety and efficacy of daratumumab in inducing complete or partial remission in people with proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). |
FERNANDO FERVENZA; | 2025-09-16 |
| 110 | Improving Physician Vaccine Recommendation Using Social Norms, Trust, and Presumptive Language PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This research examines vaccination recommendation perceptions and behaviors of physicians and advanced practice providers. |
DAN ARIELY; | 2024-02-01 |
| 111 | Effect of Probiotic and Zinc Supplementations on The Clinical Outcome in Pediatric Patients With Ventriculitis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the study is to evaluate the effect of non-antibiotic-based supplemental interventions in the management of ventriculitis among pediatric patients. The study objective is to detect the efficacy of probiotics and zinc when taken simultaneously with antibiotic treatment as immunomodulatory in increasing the recovery rate in pediatric population affected with ventriculitis. |
AIN SHAMS UNIVERSITY | 2024-12-01 |
| 112 | Economic Impact of Metagenomic Next-generation Sequencing Versus Traditional Bacterial Culture Directed CNSIs Diagnosis and Therapy in Post-neurosurgical Patients Using A Decision Analysis Model PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the current study was to assess the economic impact of using metagenomic next-generation sequencing (mNGS) versus traditional bacterial culture directed CNSIs diagnosis and therapy in post-neurosurgical patients from Beijing Tiantan Hospital. mNGS is a relatively expensive test item, and whether it has the corresponding health economic significance in the clinical application of diagnosing intracranial infection has not been studied clearly. Therefore, the investigators hope to explore the clinical application value of mNGS detection in central nervous system infection after neurosurgery. |
JIAN-XIN ZHOU; | 2025-07-01 |
| 113 | Epidemiological, Clinical and Biological Caracteristics of Patients Presenting With Invasive Meningococcal Disease in The West of France PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: An unusual increase in cases of invasive meningococcal infection between late 2022 and early 2023. These cases sometimes had atypical presentations (large numbers of bacteremias without meningitis). The distribution of serogroups was also unusual in our center (large number of serotype Y meningococcal IMD). This development comes after three years marked by the Corona-Virus-Disease-19 pandemic, which led to a profound change in the behaviors involved in the transmission of infectious diseases. Barrier measures have considerably reduced the population’s exposure to meningococcus, … |
POITIERS UNIVERSITY HOSPITAL | 2023-09-30 |
| 114 | Specific Use-results Study of IMFINZI Intravenous Infusion 120 Mg,500mg in Patients With Curatively Unresectable Biliary Tract Cancer PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To investigate onset of adverse drug reactions in patients with curatively unresectable biliary tract cancer who receive IMFINZI in combination with gemcitabine hydrochloride and cisplatin under actual use in the post-marketing setting. |
ASTRAZENECA | 2026-01-14 |
| 115 | Specific Use-results Study of IMJUDO Intravenous Infusion 25mg / IMFINZI Intravenous Infusion 120mg,500mg All Patient Investigation in Patients With Unresectable Advanced or Recurrent Non-small Cell Lung Cancer PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To collect information of safety in patients with unresectable advanced or recurrent non-small cell lung cancer who receive combination therapy of IMJUDO, IMFINZI and other platinum-based anti-cancer agents under actual use in the postmarketing setting. |
ASTRAZENECA | 2025-06-03 |
| 116 | Use of A New Rapid Multiplex PCR System for The Microbiological Diagnosis of Severe Infectious Keratitis: Impact on Therapeutic Management (ABCORFILM Study) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Microbial keratitis is a severe and often blindness-inducing pathology which represents today the first reason for long-term hospitalization (more than 5 days) in ophthalmology. Its diagnosis is clinical and leads to an immediate hospitalization in the presence of serious criteria (Mackie classification). The entire process of microbiological diagnosis requires several days before etiological confirmation and therefore delays the initiation of targeted therapy. Recently, … |
CHU DE REIMS | 2026-01-01 |
| 117 | Combined HRC, CT Cisternography and MR Cisternography in Assessment of Active CSF Rhinorrhes Compared to Operative Findings PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To assess the diagnostic accuracy of combined high resolution CT, CT cisternography and MR cisternography in pre operative assessment of active CSF leak, compared by endoscopic sinus surgery. |
GHADA ABDELSABOUR MOHAMED; | 2025-03-30 |
| 118 | ANRS 12404 TIMPANI: Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis MeNIngitis: A Phase II, Multicenter, Randomized Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Randomized phase II clinical trial which aims to assess the impact on 3-month mortality and safety of adding adalimumab to standard treatment (anti-tuberculosis drugs and corticosteroids) in HIV patients with tuberculosis meningitis in 3 countries (Brazil, Mozambique, and Zambia). |
NATHALIE DE CASTRO; | 2025-12-15 |
| 119 | Fosfomycin Versus Standard of Care in Children With Antibiotic-resistant Urinary Tract Infections PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this clinical trial is to determine, in children with multi-drug resistant urinary tract infections, whether oral fosfomycin is noninferior to standard of care antibiotics in achieving a cure without recurrence within 30 days of treatment. The The main questions the trial aims to answer are: 1. Is oral fosfomycin inferior in efficacy to the current standard to care for multi-drug resistant UTIs in children as defined by the recurrence of a UTI within 30 days of completion of therapy? 2. Is fosfomycin a safe and well-tolerated antibiotic in children? Participants aged ≥1 to <18 years of age with a clinical diagnosis of antibiotic-resistant urinary tract infections will be recruited and randomised after informed consent is obtained via computer generated randomisation into standard of care or intervention (treatment with oral fosfomycin) arms. For children randomised into the standard of care arm: Management will be as per physician preference based on institutional prescribing practices and local antibograms. For children randomised into the intervention arm: a single dose of oral fosfomycin trometamol will be prescribed (with dosage determined based on age). Both groups will complete a tolerability questionnaire and be subject to physical examination, pathology investigations and other clinical interventions tailored to their needs as per routine standard of care. Clinical observations and results of the investigation will be recorded on a case report form via an electronic database. A follow-up safety review will be performed 10 and 28 days after enrollment. |
PHOEBE WILLIAMS; | 2026-02-01 |
| 120 | Retrospective, Single Center, Single Arm Post Market Clinical Follow-Up (PMCF) Study on The Performance and Safety of Lyoplant® Used for The Replacement and Extension of Connective Tissue Structures in Neurosurgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Retrospective, single center, single arm PMCF study on the performance and safety of Lyoplant® used for the replacement and extension of connective tissue structures in neurosurgery. |
AESCULAP AG | 2023-10-01 |
| 121 | Modalities of Surgical Treatment of Chiari Malformation Disease : Clinical Study and Outcomes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Evaluation of postoperative outcomes of Chiari type I Malformation Patients at Department of Neurosurgery Assiut University Hospital . |
AHMED HAMDY HUSSEIN; | 2024-09-01 |
| 122 | Treatment Outcome With Antibiotic Use and Its Resistance Pattern Among Patient With Neonatal Sepsis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Determine Treatment outcome with antibiotic use and its resistance pattern among neonatal sepsis patients |
ASSIUT UNIVERSITY | 2024-12-31 |
| 123 | Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children – An Observational Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Autonomic Nervous System (ANS) regulates the inflammatory response in real time, just as it controls heart rate and other vital functions. Many studies have investigated induced stimulation of the vagus nerve and its therapeutic effect in inhibiting TNFα (Tumor Necrosis Factor alpha) secretion, and therefore the risk of hypotension, septic shock, organ dysfunction during inflammation. While the anti-inflammatory effect of the autonomic nervous system on inflammation has been well studied, conversely, … |
HUGUES PATURAL; | 2025-01-01 |
| 124 | A Prospective Cohort Study Of The Incidence And Risk Factors Of Recurrent Febrile Seizures And Epilepsy Following Febrile Seizures PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the recurrence and development of epilepsy in children hospitalized with their first febrile seizures. The main questions it aims to answer are: – What is the risk of recurrence after the first febrile seizure and what are the risk factors for recurrent febrile seizures in Vietnamese children? – What is the risk of developing epilepsy later in life and what are the risk factors for developing epilepsy in Vietnamese children who have had febrile seizures? |
BUI HIEU ANH; | 2025-09-15 |
| 125 | The Potential Impact of Clindamycin on Neurosurgery Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: A prospective, open-label, single center, controlled trial. 44 patients that underwent neurosurgery or presented meningitis signs, for whom Clindamycin add-on therapy to assess its effect on neurological complication in relation to Neuron-specific enolase (NSE) and Neurotensin biomarkers levels. |
REHAB WERIDA; | 2024-03-30 |
| 126 | Frequency and Severity of Thrombocytopenia in Neonatal Sepsis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of our study was to find the frequency of thrombocytopenia and its severity in neonates with sepsis |
RAGAB MOHAMED AMIN GHANDOUR; | 2024-03-01 |
| 127 | Evaluating The Effect of Prophylactic Topical Antibiotic Irrigation on Nasal Packing Colonization Following Endoscopic Skull Base Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is an interventional study that will examine the effect of prophylactic topical antibiotics on nasal packing colonization following endoscopic skull base surgery. |
CARL SNYDERMAN; | 2023-12-30 |
| 128 | A Prospective Study to Observe Adverse Effects in Patients Receiving Anti-PD1 Immunotherapy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about in the development process of adverse reactions of anti-PD1 immunotherapy. The main question it aims to observe: – The autoantibody profile of patients – The adverse reactions of patients – The changes of immune cells and cytokine in patients |
HONGYAN LI; | 2024-12-01 |
| 129 | Comparison of Duration of CSF Leak in Post Traumatic Patients Managed By Early Lumbar Drain Vs Conservative Treatment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: As limited data is available locally and internationally regarding early Lumbar drain and its effect on duration of CSF leak we have decided to compare it conservative treatment. By providing CSF an alternative route for drainage, the fistula site will remain dry. Leakage site won’t be facing CSF pressure, and this will promote early healing of the wound. |
ATIQ UR REHMAN; | 2023-08-21 |
| 130 | Feasibility of Exosome Analysis in Cerebrospinal Fluid During The Diagnostic Workup of Metastatic Meningitis From Breast Cancer Related Papers Related Patents Related Grants Related Experts Highlight: The investigators are interested in one of the most frequent tumor types causing leptomeningeal metastasis in order to investigate whether a profile can be established by a high-throughput clinical proteomic approach. All the data acquired will allow a tailored and promising approach to improve the knowledge of metastatic tumor meningitis. |
CLAIRE CHEYMOL; | 2026-03-18 |
| 131 | Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial 3 PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This pivotal, confirmatory trial seeks to independently verify the results observed in the EnACT Phase II Stage 2 trial (MB-70007). |
DAVID R BOULWARE; | 2025-01-01 |
| 132 | The Impact of Postoperative Bed Rest on The Repair of CSF Leakage After Transnasal Transsphenoidal Pituitary Surgery PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Postoperative CSF leakage is a well-known complication that might occur after transnasal transsphenoidal adenomectomy at an incidence of 0.5-15% according to different literature reports. Persistent CSF leakage may lead to intracranial hypotension or meningitis, therefore aggressive management is mandatory. The treatment is immediate repair during transsphenoidal surgery once intraoperative CSF leakage is identified, with the adjunct of postoperative bed rest and/or lumbar drainage. However, due to the advances in endoscopic endonasal skull base surgery, … |
NATIONAL TAIWAN UNIVERSITY HOSPITAL | 2024-12-31 |
| 133 | Intranasal Dexmedetomidine Versus Intravenous Dexmedetomidine for Improving Quality of The Operative Field in Functional Endoscopic Sinus Surgery: A Randomized Triple-Blind Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: compare intranasal dexmedetomidine versus intravenous dexmedetomidine for improving quality of the operative field in Functional endoscopic sinus surgery |
MOHAMED FOUAD ALGYAR; | 2023-12-15 |
| 134 | Comparison of Analgesic Effects of USG-Guided Caudal Versus Ilioinguinal/Iliohypogastric Nerve Block Techniques for Inguinal Surgeries in Children, A Randomized Controlled Trial. PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is designed to compare the analgesic effectiveness of caudal analgesia to ilioinguinal regional analgesia techniques in children undergoing inguinal surgeries. Both techniques will be done under ultrasound gaudiness, using the same local anesthesia. 128 patients will be included in this study, 64 for each technique. This study aims to know the best regional analgesia technique in children undergoing inguinal surgeries, reduction in rescue analgesia postoperatively, postoperative length of stay, and early resumption of postoperative activity. The patients will be followed up 30 minutes after the end of anesthesia in PACU, postoperatively in Ward at 2 Hours, 3 hours, … |
JYOTI BURAD; | 2024-05-01 |
| 135 | Different Approaches of Spinal Anesthesia in Patients Undergoing Cesarean Section: Midline, Paramedian and Taylors Approach PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to compare different approaches of spinal anesthesia in pregnant females who are having cesarean section. The main aim is • Which approach is better in terms of avoiding intraoperative and post operative complications Participants will be given anesthesia by 1. Midline approach 2. paramedian approach 3. Taylors approach |
MUHAMMAD ALI FAYYAZ; | 2023-01-31 |
| 136 | Using Share Decision Making With Patient Decision Aids to Help The Infant Family to Decide Whether The Baby Will Receive The Third Primary Dosing Pneumococcal Conjugate Vaccine PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Pneumococcal infection is one the common infectious disease in the world. Pneumococcal conjugate vaccine may decrease the incidence of pneumococcal infection. In Taiwan, infants usually received 2 primary dosing pneumococcal conjugate vaccines . The third primary dose of pneumococcal conjugate vaccine is still not included in public health insurance. Some infants in Taiwan did not receive the third primary dose of pneumococcal vaccine. Share decision making (SDM) with patient decision aids (PDA) provide information to infant family and to help them in making decisions about their baby’s vaccination. We develop a PDA administered for baby’s family to decide whether the baby will receive the third primary dosing pneumococcal conjugate vaccine. |
TAIPEI MEDICAL UNIVERSITY SHUANG HO HOSPITAL | 2023-09-01 |
| 137 | Investigating Visuo-spatial Abilities and Psychological Effects in West Nile and Multiple Sclerosis Patients with A Focus on A Possible Rehabilitation Protocol PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to investigate visuospatial abilities and psychological outcomes in patients with multiple scleroris (MS) and patients with West Nile virus infection (vWN). Patients will undergo a specific neuropsychological and psychological evaluation. Afterwards, patients will receive 10 sessions of cognitive training integrating digital exercises and prismatic lenses. At the end of the treatment, patients will be re-evaluated to explore for potential changes in the cognitive and psychological profile. |
IRCCS SAN CAMILLO VENEZIA ITALY | 2024-12-30 |
| 138 | Meningitis: Burden, Causes, Screening and Prevention in Rural Northern Uganda PF:8 Related Papers Related Patents Related Grants Related Experts Highlight: This study will investigate the burden, causes, diagnostics, treatments and preventive measures related to meningitis in northern Uganda. We hypothesize that understanding the burden of meningitis, risk factors, diagnostics, treatments and the preventive measures will provide information regarding the gaps in care that can be addressed in order to improve the continuum of meningitis care. we hypothesize that our data will support the advocacy for the implementation of routine vaccination for the prevention of bacterial meningitis and improving guidelines for Cryptococcal antigen (CrAg) screening for prevention of cryptococcal meningitis, … |
PAUL BOHJANEN; | 2026-01-12 |
| 139 | Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Feto-placental Doppler (Early GRAFD) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicentre, open-label, randomized controlled trial. A total of 598 singleton pregnancies with an EFW ≤10th percentile at <32+0 weeks will be recruited and randomly allocated to either the control or the intervention group. In the control group, standard Doppler-based management will be used. In the intervention group, different soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) cutoffs will be incorporated to the current protocol to adjust the frequency of ultrasounds and to plan elective delivery. |
MANEL MENDOZA; | 2025-01-30 |
| 140 | Clinical Study of Amphotericin B Colloidal Dispersion (ABCD) in The Treatment of Cryptococcal Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the efficacy and safety of ABCD in the treatment of cryptococcal meningitis in non-HIV patients at week 4, the end of induction therapy, week 10 and the end of consolidation therapy. |
LI TAISHENG; | 2023-04-30 |
| 141 | Effect of Changes in Diagnostic Protocols for Unexplained Lymphocytic Meningitis and Meningoencephalitis : A Retrospective Single-centre Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Tick-borne encephalitis (TBE) is a viral infection transmitted by ticks. TBE is the third most common cause of encephalitis in France. Across France, numerous cases of lymphocytic meningitis remain without a definitive diagnosis, notably at the Nancy University Hospital. The objective of this study is to assess the impact of a change in diagnostic practice on the work-up of undocumented lymphocytic meningitis and meningoencephalitis at Nancy University Hospital. |
LEFEVRE BENJAMIN; | 2025-09-22 |
| 142 | Validating Clinical Decision Aids for The Assessment and Management of Febrile Infants Presenting to Emergency Care in The UK and Ireland PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Febrile infants under 3 months of age represent a high risk group for serious bacterial infection (SBI) with approximately 10-20% having bacteremia, meningitis or urinary tract infection. The assessment of febrile infants is challenging, and current National Institute for Health and Care Excellence (NICE) guidance advocates a cautious approach with the majority of infants requiring a septic screen, parenteral broad-spectrum antibiotics, … |
THOMAS WATERFIELD; | 2023-12-01 |
| 143 | CHOICE UTI – Clinical Efficacy of Single Dose (Daily) IV Antibiotics Followed By 2 Days Oral Antibiotics Compared to 3 Doses (Daily) IV Antibiotics for Children With Complicated Urinary Tract Infections: A Multicentre Randomised Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Urinary tract infections (UTI) are commonly encountered in children, with 7% diagnosed with at least one UTI by the age of 19 years. The evidence for treatment of uncomplicated UTI is clear; oral antibiotics are as good as intravenous (IV) antibiotics, usually for a total of 7 days. Complicated UTIs (cUTIs) on the other hand, are common reasons for hospital admissions for IV antibiotics and constitute a major burden for healthcare systems. There is considerable variation in care for children who present with UTI and have complicating features such as vomiting, dehydration, … |
LAILA IBRAHIM; | 2025-12-03 |
| 144 | Causes and Management of Aseptic Meningitis : A Retrospective Cohort Study in Strasbourg University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The diagnostic and therapeutic management of patients with aseptic meningitis is a challenge for the practitioner. There are many etiologies of this condition (infectious, inflammatory, neoplastic, drug-induced), which it is necessary to know how to evoke and look for specifically. |
ANNE-SOPHIE KORGANOW; | 2022-12-31 |
| 145 | Translational Immunodiagnostics in Suspected Stroke (TrImS): A Two-centre, Pragmatic, Prospective, Observational Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic biomarkers that enable early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis. 2. to identify early brain- and pathology-specific, panorOmic biomarkers in saliva that enable early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis. 3. to derive biomarker platforms of models for early acute stroke detection, diagnosis, dynamics, differentiation, monitoring, prediction and prognosis 4. to validate these models in independent and external datasets |
TIMOTHY HUDSON RAINER; | 2025-05-30 |
| 146 | Observational Pilot Study With TachoSil As A Ventricular Sealant PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The working hypothesis in this study is that after entering the cerebral ventricular system the sealing with TachoSil is effective and safe. A more specific hypothesis is that the use of Tachosil for brain surgery with ventricular entry reduces the number of postoperative complications (hydrocephalus, CSF leak, meningitis and pseudomeningocele). |
PILAR TEIXIDOR RODRIGUEZ; | 2023-02-03 |
| 147 | A Phase 3 Trial to Evaluate The Safety, Immunogenicity, and Non-Interference With Concomitant Routine Vaccines, of A Meningococcal Serogroup ACYWX Conjugate Vaccine (NmCV-5) in Comparison With MenACWY-TT Conjugate Vaccine in Healthy Malian Infants PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Infants aged 9 months will be randomized to receive a meningococcal vaccine at 9 months or 15 months. Infants randomized to the 9-month age group will be further randomized in a 2:1 ratio to receive a single dose of the experimental meningococcal vaccine (NmCV-5) or a single dose of the comparator meningococcal vaccine (MenACWY-TT). Prospectively identified and consented infants randomized to the 15-month age group will return when aged 15 months and will be randomized in a 2:1 ratio to receive a single dose of NmCV-5 or a single dose of MenACWY-TT. |
WILBUR CHEN; | 2026-03-31 |
| 148 | Impact of Post-ARDS Covid Sedation on Persistent Neuroinflammation (PETDEXDOCOVID) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: ICU Patients admitted after ARDS due to COVID infection should be weaned from invasive mechanical ventilation as quickly as possible. 60% of ARDS patient after COVID infection admitted in ICU developp a delirium during mechanical ventilation weaning, serious event that can lead to death or acute and late complications since 30% of patients who had a delirium in ICU develop cognitive sequelae. Based on epidemiological arguments and mouse models, severe neuroinflammation is considered to be one of the physiopathological mechanisms causing delirium during ventilatory weaning. In addition to its sedative properties, dexmedetomidine exhibits neuroprotective effects. In experimental models, … |
ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS | 2023-01-30 |
| 149 | Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis (TB): A Proof of Concept Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Resistance to anti-tuberculosis drugs is a continually growing problem. Multidrug-resistant tuberculosis (MDRTB) is resistance to at least rifampicin and isoniazid, and extensively drug-resistant TB is additional resistance to a fluoroquinolone and a second injectable line drug. Methods currently employed in testing for resistance are inadequate and a contributing factor to the 40-50% MDR-TB treatment success rate. Current drug susceptibility testing methods are slow for most drugs, taking weeks. Rapid molecular methods such as the line probe assays, e.g. Hain GenoType MDRTBplus and sl, provide resistant calls to only a limited number of drugs, … |
KEERTAN DHEDA; | 2025-06-01 |
| 150 | Phase I/II Clinical Trial of Intrathecal Pemetrexed As First Line Intrathecal Chemotherapy in Patients With Leptomeningeal Metastasis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Intrathecal chemotherapy is one of the most important treatment modalities for leptomeningeal metastasis of solid tumors. In the previous study(Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastasis From Non-small Cell Lung Cancer: A Prospective Pilot Clinical Trial. ClinicalTrials.gov identification number: NCT03101579), pemetrexed presented feasibility of intrathecal administration. Pemetrexed at 10 mg dose level on the schedule of 1-2 times per week was recommended as an intrathecal administration agent for patients with refractory leptomeningeal metastases from non-small-cell lung cancer in the previous study. Moreover, … |
ZHENYU PAN; | 2023-04-01 |
| 151 | Diagnostic Accuracy of Imaging Findings in Tubercular Meningitis/Spinal Tubercular Arachnoiditis and Correlation With Outcomes in Patients With Tubercular Meningitis, Spinal Tubercular Arachnoiditis PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this Diagnostic accuracy study is – To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and – To study the correlation of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis with clinical outcomes after completion of therapy – Secondary objectives – To study the proportion of patients having clinical or imaging features of spinal tubercular arachnoiditis – To study the factors determining outcomes in patients with spinal tubercular arachnoiditis – … |
ARUNMOZHIMARAN ELAVARASI; | 2024-02-01 |
| 152 | A Randomized Trial of The Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele Sac Repair PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction: Meningomyelocele is a common congenital neural tube defect. To reduce complications, early surgery and a multidisciplinary approach is needed. In this study, the investigators administered platelet-rich plasma (PRP) to newborns with meningomyelocele following corrective surgery to minimize cerebrospinal fluid (CSF) leakage and accelerate the healing of the immature pouch tissue. The investigators compared these with a control group that did not receive PRP. Patients and Methods: Of the 40 newborns who were operated on with the diagnosis of meningomyelocele, 20 patients received PRP after surgical repair, and 20 were followed up without PRP. In the PRP group, … |
ÖZKAN ARABACI; | 2022-12-15 |
| 153 | Safety, Tolerability and Effects on The Microbiome of Neonatal Administration of Lactiplantibacillus Plantarum ATCC 202195 With or Without Fructooligosaccharide for One or Seven Days: A Phase II Randomized Placebo-controlled Trial in Dhaka, Bangladesh PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Sepsis is a life-threatening clinical syndrome and a leading cause of neonatal deaths worldwide. The burden of neonatal sepsis and severe infection (SI) is particularly high in areas of South Asia and other resource-limited settings. The goal of the Synbiotics for the Early Prevention of Severe Infections in Infants (SEPSIS) phase II L. plantarum trial is to generate knowledge on the safety, tolerability and effects on the microbiome of Lactiplantibacillus plantarum, with or without fructooligosaccharide, in infants (birth to 60 days of age) in Dhaka, … |
DANIEL ROTH; | 2022-11-30 |
| 154 | A Single-center, Randomized, Blind, Positive Control Phase III Clinical Trial to Evaluate Immunogenicity and Safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Healthy Volunteers Aged From 3 to 5 Months PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the immunogenicity and safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in healthy volunteers aged from 3 to 5 months. |
BEIJING ZHIFEI LVZHU BIOPHARMACEUTICAL | 2023-10-18 |
| 155 | Neostigmine and Glycopyrrolate for The Treatment of Post Dural Puncture Headache After Known Dural Puncture With A Tuohy Needle: A Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate Neostigmine and Glycopyrrolate to treat post-dural puncture headache (PDPH) to reduce the proportion of postpartum women with a PDPH requiring epidural blood patch (EBP) who developed a PDPH after accidental dural puncture. |
MARK D. ROLLINS; | 2026-03-23 |
| 156 | A Phase 1/2, Open-label Study Investigating The Safety, Tolerability and Efficacy of ASP7517 As A Single Agent and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors Known to Express WT1 Antigen PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study was to evaluate the safety, tolerability, and clinical response of ASP7517, and determine the Recommended Phase 2 Dose (RP2D) and/or the Maximum Tolerated Dose (MTD) of ASP7517 when administered as a single agent and in combination with pembrolizumab. This study also evaluated other measures of anticancer activity of ASP7517 when administered as a single agent and in combination with pembrolizumab based on central and local assessment. |
ASTELLAS PHARMA GLOBAL DEVELOPMENT | 2025-08-08 |
| 157 | The Associations Between Perioperative Depression or Anxiety, Salivary Cortisol and Α-amylase, and Administered Anesthesia Type in Knee Arthroscopy With Anterior Cruciate Ligament Reconstruction (ACLR): Prospective, Randomized Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Perioperative depression and/or anxiety play a critical role in patient presentation, satisfaction and outcomes. The aim of this study is to assess the level of perioperative depression and/or anxiety in patients with arthroscopic knee surgery and to evaluate their relationship with anesthesia approach (general anesthesia or non general anesthesia). The perioperative characteristic of depression or anxiety is assessed by Hospital Anxiety and Depression Scale (HADS) questionnaires and the level of salivary cortisol, salivary α-amylase (sAA) and blood glucose. |
CONGCONG HUANG; | 2023-06-30 |
| 158 | Strengthening The Evidence for Policy on The RTS,S/AS01 Malaria Vaccine: Assessment of Safety and Effectiveness Using Case-control Studies Embedded in The Malaria Vaccine Pilot Evaluation PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The ongoing Malaria Vaccine Pilot Evaluation (MVPE) is being conducted in Ghana, Malawi and Kenya through community and sentinel hospital surveillance systems and a series of household surveys (to measure vaccine coverage). The Malaria Vaccine Pilot Evaluation-Case Control (MVPE-CC) registered here as observational study is embedded within MVPE comprising case-control studies of clinical and mortality outcomes. Each case will require four controls, and caregiver informed consent will be required prior to study activities. These observational case control studies will measure as complementary information to what is being collected through MVPE: 1. Safety among children who received the malaria vaccine, … |
KWAKU POKU ASANTE; | 2025-02-28 |
| 159 | COVID-19 Booster Vaccination in Persons With Multiple Sclerosis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The success of the U.S. vaccination program against SARS-Cov-2 is shown by a dramatic drop in infection rates, hospitalizations and deaths.However, it appears that many persons who take medications that chronically suppress the immune system do not produce neutralizing antibodies to COVID-19 proteins in response to vaccination. This group includes a significant number of persons with multiple sclerosis (PWMS), … |
JOSEPH B GUARNACCIA; | 2022-05-30 |
| 160 | An Observational, Retrospective, Clinical Performance Study Testing Residual Specimens of Cerebrospinal Fluid Obtained By Lumbar Puncture From Meningitis/Encephalitis Subjects Using The QIAstat-Dx® Meningitis/Encephalitis Panel PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Study for performance evaluation of the QIAstat-Dx® Meningitis/Encephalitis Panel in comparison with other chosen comparator methods. |
QIAGEN GAITHERSBURG | 2025-04-16 |
| 161 | Augmented Renal Clearance in Neurocritical Care Population: A Prospective Multicenter Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion dollars. Seizures and infections are common complications following acute neurological illnesses and contribute significantly to poor outcomes if not promptly treated with appropriately dosed anti-seizure medications and antibiotics, respectively. Limited research suggested that many of those patients present with a phenomenon called augmented renal clearance (ARC) or, in other words, … |
SHERIF H MAHMOUD; | 2026-02-18 |
| 162 | EXtended Use of FOsfomycin for The Treatment of CYstitis in Primary Care PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cystitis is the most frequent reason for women to visit their general practitioner. More than 600.000 women suffer from urinary tract infections in The Netherlands each year. Currently, the 1st choice treatment for uncomplicated cystitis is nitrofurantoin (NIT) for 5 days. The second choice is 3 gram fosfomycin-trometamol (FT) in a single dose. FT is increasingly prescribed because it has few side-effects and it has a patient-friendly dosing scheme. Previous research did not show significant difference in efficacy between fosfomycin and nitrofurantoin, … |
MJM BONTEN; | 2022-02-14 |
| 163 | Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This prospective randomized controlled study examines whether the type of glove used (sterile vs clean) for cervical examination to assess progression in labor impacts the rates of intrapartum and/or postpartum infection in patients during labor or induction of labor at term. |
STACY SLAT; | 2022-09-01 |
| 164 | Reduction of Adverse Events and Re-Presentation to Medical Care After Intravenous Immunoglobulin Treatment in Children With Immune Thrombocytopenia With A Scheduled Post-Infusion Medication Strategy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a single hospital system, single-arm year-long pilot to evaluate the feasibility of enrolling children with ITP who are receiving IVIG for treatment of disease to a scheduled post-infusion medication for 72 hours following IVIG infusion. This year-long feasibility pilot will test the (1) feasibility of enrollment and the willingness of families to participate in a scheduled medication regimen and (2) adherence of patients and families to the scheduled medication regimen. Clinical outcomes, as defined by rates of headache or nausea/vomiting or other adverse event following IVIG, return to medical care, … |
MEGAN GILBERT; | 2023-10-01 |
| 165 | A Natural History Study to Assess The Clinical Outcomes of Patients With Complement Factor I Deficiency-Mediated Disease Related Papers Related Patents Related Grants Related Experts Highlight: This study will follow participants with a disease which is associated with an absence or deficiency in Complement Factor I (CFI) as confirmed in the CFI-001 screening study. |
CATALYST BIOSCIENCES | 2022-02-10 |
| 166 | Validation of A Predictive Rule for The Diagnosis of Viral Meningitis in Adult Emergency Departments PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Meningitis is the development of an inflammatory reaction in the meningeal space, most often of infectious origin. Many pathogens can cause meningitis, the severity of which varies greatly. Patients presenting with a febrile meningeal syndrome are most often managed in the emergency room, where the challenge for physicians is to quickly differentiate bacterial and viral meningitis. Viral meningitis is the most common, … |
JEAN-CHRISTOPHE CALLAHAN; | 2022-08-26 |
| 167 | Prospective, Open-label, Single-arm, Multicentre Phase 3 Study to Evaluate The Pharmacokinetics, Efficacy, Tolerability, and Safety of Subcutaneous Human Immunoglobulin (Newnorm) in Patients With Primary Immunodeficiency Diseases PF:2 Related Papers Related Patents Related Grants Related Experts Abstract: Rate of SBIs (defined as bacteraemia/sepsis, bacterial meningitis, osteomyelitis/septic arthritis, bacterial pneumonia, and visceral abscess) per person-year on treatment. Average … |
OCTAPHARMA | 2025-10-03 |
| 168 | A Phase IV Double Blind Randomised Controlled Trial (DBRCT) to Investigate The Effect of PCV-13 and PPV-23 on Pneumococcal Colonisation Using The Experimental Human Pneumococcal Challenge (EHPC) Model in Healthy Adults PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: To determine the effect of PCV-13 and PPV-23 vaccination versus control on experimental pneumococcal colonisation of 2 clades of serotypes 3 and 6B at 1 month and 6 months post vaccination respectively, using the EHPC model. |
LIVERPOOL SCHOOL OF TROPICAL MEDICINE | 2023-12-31 |
| 169 | Long-term Sequelae of Childhood Meningitis and Meningococcal Purpura Fulminans in Ile De France: A Multidisciplinary Approach PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: While the initial evolution of meningococcal meningitis (MM) is well described, there are few data on the long-term evolution, beyond 1 year. The objective of this research is to evaluate the sequelae of MM beyond 1 year in patients with a history of MM followed in Paris area, France. Most children with MM in France have been included in the MM register and are still being followed. Parents will be offered a detailed clinical evaluation of their child including: a clinical and neurological examination, a cognitive performance assessment, an auditory, … |
CENTRE HOSPITALIER INTERCOMMUNAL CRETEIL | 2025-06-13 |
| 170 | Phase 1/2a Trial of Placental Mesenchymal Stem Cells for Repair of Fetal Myelomeningocele PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Spina bifida, or myelomeningocele (MMC), is a birth defect that results in paralysis, excess fluid on the brain (hydrocephalus), and impaired ability to urinate and have bowel movements normally. In a previous study (the MOMS trial), surgery before birth (in-utero/fetal surgery) was shown to reduce the need for shunting for hydrocephalus. There was also some improvement in ambulation, … |
DIANA L FARMER; | 2026-01-20 |
| 171 | The Role of Serum Procalcitonin in Diagnosis and Detection of Outcome of Acute Bacterial Meningitis in Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Meningitis is one of the most common central nervous system (CNS) infections encountered in infants and children. The source of infection in meningitis can be bacterial, viral, fungal, or parasitic in origin . Bacterial meningitis is a paediatric emergency with high mortality and morbidity rate. Hence it must be diagnosed and treated promptly. But the similar clinical presentation often makes it difficult to differentiate bacterial and non-bacterial aetiologies in children . |
MARINA WAHIB SHAWKY; | 2022-07-15 |
| 172 | Biosimilars of Rituximab in ANCA-associated Vasculitis Compared to The Originator (BRAVO): A CanVasc Multicentre Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this multicentre observational study is to compare the safety and effectiveness of rituximab biosimilars to the originator in Canadian patients with Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA), two main forms of ANCA-associated vasculitis (AAV). The main questions it aims to answer are: * Is there a difference in vasculitis control between originator and biosimilar rituximab? * Is there a difference in adverse effects between originator and biosimilar rituximab? * In the Canadian healthcare context, … |
ARIELLE MENDEL; | 2025-12-02 |
| 173 | Are Long Term Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)? PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The principal objective of this study is to compare the incidence of ventriculostomy related infections (VRIs) in patients who receive twenty-four hours of antibiotics, beginning no more than sixty minutes prior to EVD placement, to the incidence of VRIs in patients who also receive a pre-procedural dose of antibiotics with continued dosing of antibiotics for the duration of the external ventricular drain (EVD). At this time, the duration of prophylactic antibiotic use with antibiotic impregnated EVDs is unknown. |
DAVID C ALTSCHUL; | 2026-02-02 |
| 174 | Early Diagnosis and Treatment Monitoring of Native and Device-associated Meningitis Using D-lactate, A Pathogen-specific Diagnostic Biomarker in Cerebrospinal Fluid PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Device-associated meningitis is a severe complication after implantation of various central nervous system (CNS) devices such as ventriculoperitoneal (VP) and ventriculoatrial (VA) shunts, external ventricular drains (EVD), lumbar drains (ELD) and intrathecal pumps. In contrast to native meningitis, these infections are hard to diagnose both clinically and on the laboratory basis due to (i) atypical clinical manifestation, (ii) overlapping inflammation following surgery, and (iii) common culture negativity due to previous antibiotic therapy and slow growth of low-virulent pathogens. Also, … |
ANDREJ TRAMPUZ; | 2024-05-31 |
| 175 | An Observational Clinical Performance Evaluation Study Testing Residual Specimens of Cerebrospinal Fluid Obtained By Lumbar Puncture From Meningitis/Encephalitis Subjects Using The QIAstat-Dx® Meningitis/Encephalitis Panel PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Study for performance evaluation of the QIAstat-Dx® Meningitis/Encephalitis Panel in comparison with other chosen comparator methods. |
QIAGEN GAITHERSBURG | 2023-08-31 |
| 176 | Pharmacokinetics and Tolerability of Adjunctive Linezolid for The Treatment of Tuberculous Meningitis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a phase II randomized open-label trial of high versus standard dose rifampin (RIF) with or without linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at Masaka Regional Referral Hospital in Uganda. Initial randomization will be to high (35 mg/kg/day) versus standard (10 mg/kg/day) dose oral rifampin for the first 4 weeks of intensive therapy. Participants will then undergo a second randomization to linezolid 1200 mg daily versus no linezolid for the first 4 weeks of therapy. The primary aims are (1) to determine the cerebrospinal fluid and plasma pharmacokinetics of adjunctive LZD 1200 mg daily in TBM patients receiving high or standard dose RIF and (2) to evaluate the tolerability of a 4-week course of LZD in TBM patients. |
FELICIA CHOW; | 2023-11-01 |
| 177 | BCG Vaccination Scar Formation in Children Under Five Years :Factors Affecting Its Formation and Subsequent Adverse Effects PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Study of BCG Vaccination scars of under five years old children . Estimation of the frequency of children without BCG scar after BCG vaccine . Evaluation of factors which may affect scar formation . Tuberculin skin test response in children without BCG scar . Frequency of vaccine adverse effects as injection-site abscess, lymphadenitis, severe local reaction, and disseminated BCG infection. |
SHIMAA ABD ELHAMID MAHRAN; | 2021-12-01 |
| 178 | A Phase III Randomized Controlled Multi-centre Trial to Evaluate The Efficacy of The R21/Matrix-M Vaccine in African Children Against Clinical Malaria PF:6 Related Papers Related Patents Related Grants Related Experts Abstract: This will be a double-blind, individually randomised trial. In the first phase of the trial, participants were randomised 2:1 to receive R21/Matrix-M malaria vaccine or a control … |
ADRIAN VS HILL; | 2026-02-23 |
| 179 | Short Intervention and Measurement of Pharmacokinetics of Linezolid in Tuberculosis Meningitis: A Pharmacokinetics and Safety/Tolerability Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Tuberculosis meningitis (TBM) is the most severe manifestation of TB, resulting in death or neurological disability in up to 50% of affected patients, despite antibacterial treatment. This TBM treatment follows the model for pulmonary TB by using the same first-line TB drugs (a combination of rifampicin, isoniazid, pyrazinamide and ethambutol) and the same dosing guidelines, although it is known that penetration of two of these drugs (rifampicin and ethambutol) into cerebrospinal fluid (CSF) is limited. Improvement of treatment of TBM is urgently needed. To do so, … |
AHMAD RIZAL GANIEM; | 2023-07-01 |
| 180 | A Phase 2 Open-label Trial Evaluating The Efficacy and Safety of Daratumumab in Treatment of Patients With Active Lupus Nephritis PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research is to study the safety and efficacy of daratumumab in inducing complete or partial remission in patients with active lupus nephritis. |
FERNANDO FERVENZA; | 2025-07-03 |
| 181 | Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways. Therefore, we conducted this multicenter, prospective, and randomized controlled study. It was designed to evaluate the diagnostic performance and its impact on the outcomes of the patients enrolled. As such, we came to the results of the optimal process of diagnosis and treatment strategy of encephalitis/meningeal syndromes with improved effective treatments. |
WEN-HONG ZHANG; | 2023-04-30 |
| 182 | Analysis of The Cognitive-behavioral Dysfunctions Profile and The Potential of Neuroplasticity in Patients With Brain Tumors Subjected to Selected Radiotherapy Techniques and The Possibility of Their Compensation By Psycho-physical Training PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Primary and secondary brain tumors are a constant challenge for the medicine. Tissue sensitivity to ionizing radiation differs and depends on numerous factors and the same dose of radiation may produce different effects in particular structures of the CNS. It can also affect the surrounding healthy tissues and lead to adverse effects like the cognitive or physical function impairment. One of brain structures most sensitive to ionizing radiation is the limbic system, especially the hippocampus, because it is here that the postnatal neurogenesis takes place via neural stem cells, … |
KATARZYNA HOJAN; | 2025-03-31 |
| 183 | Study of The Inflammatory Response to Enterovirus Meningitis in Newborns, Infants and Children, As Assessed By Cytokine Levels in Blood and Cerebrospinal Fluid. Case-control Comparison Using An Existing Cohort PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Enteroviruses (EV) are the most frequent cause of acute meningitis in the paediatric population. Detection of enterovirus in cerebrospinal fluid (CSF) specimens by Polymerase Chain Reaction (PCR) is the gold standard diagnostic test. Recently, our laboratory published the BLEDI study which highlighted the interest of detecting EV in the blood of the paediatric population : (i) EV was found in more than a quarter of cases in the blood of infants admitted to hospital with isolated fever and (ii) detection of EV was more frequent in the blood than in CSF in neonates and infants with isolated fever, … |
CHRISTINE ARCHIMBAUD; | 2021-06-01 |
| 184 | Free Middle Turbinate Flap for Repair of Low Flow Cerebrospinal Fluid Leak PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Limited literature has been reported the use of free middle turbinate flap during an endoscopic approach to treat cerebrospinal fluid (CSF) leak, and the results were inconclusive. The overall purpose of this study was to assess the efficacy and safety of free middle turbinate flap in reparing CSF leak during an endoscopic approach. |
QIANGPING WANG; | 2023-01-01 |
| 185 | A Phase III, Open-label, Prospective, Multicenter Study to Assess Efficacy, Safety, and Pharmacokinetics of Kedrion Intravenous Human Normal Immunoglobulin (IVIg) 10% in Pediatric Patients Affected By Primary Immunodeficiency Disease (PID) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to assess efficacy, safety and pharmacokinetics of Kedrion Immunoglobulin 10% (KIg10) in pediatric patients with Primary Immunodeficiency Disease (PID). |
CHIARA AZZARI; | 2026-01-15 |
| 186 | Utility of Ultrasound-Guided Site Marking in Pediatric Lumbar Punctures PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The standard way to identify landmarks in the spine before inserting a needle for a lumbar puncture is to feel by touch. The purpose of this research is to determine if doing an ultrasound to identify landmarks before performing a lumbar puncture will improve the first-time success rate of the needle insertion in pediatric patients. |
RAHUL PANDEY; | 2023-03-01 |
| 187 | Establishment of Prevention and Control System of Central Nervous System Infection PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Central nervous system (CNS) infection is a common nervous system acute and severe disease, mainly manifested as encephalitis, meningitis and meningoencephalitis, but also manifested as brain abscess and brain granuloma et al. The basis for the diagnosis of CNS infection lies in the detection of pathogens from brain parenchyma or cerebellar spinal fluid (CSF). However, CSF is relatively difficult to obtain and the sample size is small, which limits the rapid and definite diagnosis of CNS infection pathogens. In addition, CNS infection usually has non-specific clinical manifestations, … |
XUANWU HOSPITAL BEIJING | 2025-12-31 |
| 188 | Prospective, Multicentre Evaluation of The Accuracy of CAD4TB and C-reactive Protein Assay As Triage Tests for The Diagnosis of Pulmonary Tuberculosis in Presumptive Adult TB Patients (TB TRIAGE+ Accuracy) PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: In the TB TRIAGE+ ACCURACY study, the accuracy of the following products will be determined: * CAD4TB (Delft Imaging System, NL), a digital chest x-ray analysis software * Afinion CRP assay (Alere Afinion, USA), … |
KLAUS REITHER; | 2025-09-22 |
| 189 | Intensified Tuberculosis Treatment to Reduce The Mortality of HIV-infected and Uninfected Patients With Tuberculosis Meningitis: A Phase III Randomized Controlled Trial (Acronym: INTENSE-TBM) PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: INTENSE-TBM is randomized controlled, phase III, multicenter, 2 x 2 factorial plan superiority trial assessing the efficacity of two interventions to reduce mortality from tuberculous meningitis (TBM) in adolescents and adults with or without HIV-infection in sub-Saharan Africa: – Intensified TBM treatment with high-dose rifampicin and linezolid, compared to WHO standard TBM treatment. – Aspirin, compared to not receiving aspirin. The trial will be open-label for anti-TB treatment and placebo-controlled for aspirin treatment. |
FABRICE BONNET; | 2024-12-01 |
| 190 | Immunisation for Adolescents Against Serious Communicable Diseases PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to implement a targeted 4CMenB immunisation program in young people aged 14-19 years in the Northern Territory (NT). As part of the NT program consenting 14-19 year olds will receive 2 doses of the licensed 4CMenB vaccine. An oropharyngeal swab will be collected on the same day as the first dose of the vaccine and 12 months later to assess carriage of Neisseria meningitidis. The first swab will assess baseline carriage prevalence among 14-19 year olds in the NT. The swab taken 12 months later will provide data on the change in carriage that may occur after implementation of the immunisation program. Emerging evidence suggests that the 4CMenB vaccine may be protective against gonorrhea. Therefore, vaccine effect (impact and effectiveness) against both invasive meningococcal disease (IMD) and gonorrhea in the NT will be assessed using data from the above study comparing notifications between vaccinated and unvaccinated as well as comparing pre and post implementation periods. |
HELEN MARSHALL; | 2024-12-31 |
| 191 | Short- Term Follow Up Of Neonates Born With Neural Tube Defect PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Neural tube defects (NTD), which is the most common anomaly of the central nervous system, which can be diagnosed during antenatal period, brings many problems both in the neonatal period and in advanced ages. Open neural tube defects, in particular, progress with sensory-motor deficits due to the risk of infection and neural tissue loss from birth, and should be followed closely from the neonatal period. Newborns born with a neural tube defect should be operated within the first 72 hours postnatal and the defect should be closed. In this hospital, … |
UMIT AYSE TANDIRCIOGLU; | 2021-12-31 |
| 192 | Long Term Follow Up of Patients With Thoracolumbar Spondylodiscitis Treated Surgically By Posterior Approach in Assiut University Hospitals PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the long term outcomes of patients with thoracolumbar spondylodiscitis treated surgically by posterior approach. Outcomes include bony fusion, neurological improvement, pain improvement, implant related complication, recurrence of infection and or reoperation rate |
MICHEAL BASSEM ELIA; | 2021-07-01 |
| 193 | The Effect and Safety of Three Initial Introduction Treatments on HIV-infected Patients With Cryptococcal Meningitis: A Multi-center, Random and Prospective Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Three induction treatment strategies [ voriconazole +5FC vs. amphotericin deoxycholate (0.4-0.5 mg/kg/d)+5FC vs. amphotericin deoxycholate (0.7-1.0 mg/kg/d)+5FC ] for HIV-infected patients with cryptococcal meningitis were compared. |
LIJUN XU; | 2022-12-01 |
| 194 | Protecting Brains and Saving Futures – The PBSF Protocol: A Prospective Multicenter and Observational Study on The Use of Telemedicine for Neurocritical Care in High-risk Newborns in Brazil PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care. Such initiative involves the use of standardized protocols, continuous and specialized brain monitoring with electroencephalography (EEG), amplitude integrated EEG (aEEG) and Near Infrared Spectroscopy (NIRS), neuroimaging and training. Brazil is a very large country with disparities in health care assessment; some neonatal intensive care units (NICUs) are not well structured and trained to provide adequate neurocritical care. However, … |
GABRIEL VARIANE; | 2023-12-31 |
| 195 | Central Nervous System Disorders Following Hematopoietic Stem Cell Transplantation: A Prospective Observational Trial From The Infectious Diseases Working Party and The Transplant Complications Working Party of The European Society for Blood and Marrow Transplantation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: All patients undergoing allogeneic or autologous HSCT at the participating centres will be observed. Once a diagnosis of CNS disorder is made, additional data will be reported for these patients. We will identify clinical and diagnostic characteristics such as cerebrospinal fluid (CSF) and neuroimaging patterns, risk factors, response to treatment (including novel antifungal agents such as isavuconazole) and outcome. In addition, risk factors for CNS disorders after allogeneic and autologous HSCT will be analyzed using a prospectively assessed matched control group. In the future, this study might be the basis for an interventional trial (e.g. using a prophylactic approach). |
MARTIN SCHMIDT-HIEBER; | 2023-08-01 |
| 196 | Clinical Study of Individualized Vancomycin Dosing Based on Population Pharmacokinetic Model for Severe Infections PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to compare the clinical efficacy of individualized dosing based on the population pharmacokinetics (PK) model and empirical dosing of vancomycin in participants with severe infections. It aims to answer whether individual vancomycin dosing based on population PK model is superior to empirical dosing in terms of clinical efficacy and safety. Participants will be randomly divided into experimental group and control group. The experimental group will be guided by the population PK model for individual dosing, and the control group will be given empirical dosing. Demographic data, clinical characteristics of participants, … |
HAINAN ZHANG; | 2024-12-01 |
| 197 | Efficacy and Safety of Cyclophosphamide in The Treatment of Refractory Proliferative Arachnoiditis in Central Nervous System Tuberculosis- A Randomized Double Blinded Placebo Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Tubercular meningitis occurs in around 10% of those with extrapulmonary tuberculosis and is a major cause of mortality and morbidity. Inspite of effective Anti-tubercular drugs, still around 30% of patients develop complications due to arachnoiditis such as spinal tubercular radiculomyelitis, optico-chiasmatic arachnoiditis, development of new tuberculomas after starting therapy etc. which are probably immune mediated inflammatory responses due to paradoxical reaction to ATT. The management of arachnoiditis is far from satisfactory. High dose methylprednisolone, intrathecal hyaluronic acid, thalidomide have been tried in small case series and case reports. However, … |
ARUNMOZHIMARAN ELAVARASI; | 2024-12-31 |
| 198 | Meningitis Encephalitis: A Metagenomics-Based Etiology & Epidemiology Research (MEMBER Research) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Autoimmune encephalitis (AE) is caused by abnormal immune response mediated by autoimmune antibodies of patients, which can be detected by a serial of autoimmune antibodies[4,5,6,7]. At present, the traditional infection diagnosis mainly relies on microbial culture method, which has the characteristics of long cycle, high cost, low detection rate and complex detection process. About 30-60% of encephalitis have unknown etiology[2,3]. On the other hand, the diagnosis and classification of noninfectious encephalitis mainly depend on the detection of autoimmune antibodies, the scope of diagnosis and differential diagnosis is limited, … |
JIA WEI WANG; | 2023-06-01 |
| 199 | The Evaluation of The Effect of Wharton’s Jelly Mesenchymal Stem Cells (WJMSCs) on The Immune System of Patients With Amyotrophic Lateral Sclerosis (ALS) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to evaluate the safety of intrathecal administration of Wharton’s Jelly Mesenchymal Stem Cells (WJMSC) and the impact on the immune system of patients with Amyotrophic Lateral Sclerosis. |
POLSKI BANK KOMOREK MACIERZYSTYCH JSC PBKM | 2023-04-01 |
| 200 | Pneumococcal Nasopharyngeal Colonization As Predictor of Community-Acquired Pneumonia in Adults With Chronic Diseases: A Real-word Evidence, Prospective, Observational, Multicenter, Cohort Study PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Streptococcus pneumoniae (pneumococcus) is a commensal bacterium, often isolated in the nasopharynx of preschool children and older adults with weakened immune systems, a pathogen that remains the leading cause of Community-Acquired Pneumonia (CAP) and invasive pneumococcal disease (IPD) such as Sepsis and Meningitis. CAP is the sixth leading cause of overall mortality and the first cause of infectious disease in Colombia and the world (Montúfar et al, 2013; GBD, 2016; WHO, 2018), and both its incidence and prevalence have remained stable over the past 3 decades. Likewise, … |
LUIS F REYES; | 2022-12-01 |