Clinical Digest: Recent Clinical Trials on Traumatic Brain Injury (2026-04)
To assist researchers and healthcare practitioners in staying up-to-date with the latest advancements in clinical research, the Clinical Digest Team has compiled a comprehensive list of recent clinical trials related to Traumatic Brain Injury. These trials are organized by their release dates for your convenience. (Last updated on: 2026-04-06)
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TABLE 1: Clinical Digest: Recent Clinical Trials on Traumatic Brain Injury (2026-04)
| Clinical Trial | Contact(s) | Updated | |
|---|---|---|---|
| 1 | Telehealth-Adapted Compensatory Training and Intervention for Cognition for People With Mild Cognitive Impairment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to develop a five-week virtual cognitive training intervention for people with Mild Cognitive Impairment (MCI) based off an existing eight-week intervention. The main question it aims to answer is: • Is five weeks of training as good as eight weeks in improving cognition, quality of life, daily functioning, and mood, … |
CAMERON K PERRIN; | 2026-03-27 |
| 2 | Cognitive Rehabilitation for Treatment of Anger in Veterans With TBI (Traumatic Brain Injury) and PTSD (Post-traumatic Stress Disorder) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized clinical trial will enroll 100 Veteran-family/friend dyads to test the efficacy of CALM in treating anger in TBI and PTSD. The investigators hypothesize that compared to an active control group, Veterans randomized to the CALM group will demonstrate: * Significantly larger decreases in anger dysregulation, impulsivity, and executive dysfunction. * Significantly larger improvements in social and adaptive functioning including less aggression. * Significantly larger reduction in PTSD symptoms and suicidal ideation. The study targets Veterans who experience difficulties with anger and impulsivity due to TBI and PTSD. These issues are common, … |
ERIC ELBOGEN; | 2026-03-13 |
| 3 | Development of A Portable VR-based Chromatic Pupilloperimeter for Diagnosis and Monitoring of Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Accurate and non-invasive methods for objectively identifying and monitoring head injuries (such as a concussion) are still an unmet need. It is known that pupil constriction in response to light stimuli can reflect changes in neural activity in the brain and is associated with sleep disturbances. The investigators aim to examine the feasibility of using virtual reality goggles for monitoring traumatic brain injury by analyzing the pupillary response to multifocal chromatic stimuli. The VR device was programmed to present brief, low-intensity light stimuli (without glare), while the headset’s camera records the pupil’s reaction. |
YGAL ROTENSTREICH; | 2026-04-02 |
| 4 | Mechanisms Underlying Carbon Dioxide Induced Protein Efflux in Health and Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use a counter-balanced design, … |
ANDREW MAYER; | 2026-02-23 |
| 5 | Goal-oriented Rehabilitation of Executive Functioning Using Video-telehealth to Improve Community Reintegration for Veterans With Chronic TBI and Cognitive Difficulties PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Provision of interventions that address cognitive and emotional problems faced by Veterans with history of TBI pursuing community reintegration is an important concern for VA. Using telerehabilitation, the current project will help determine whether goal-directed training of attentional control functions via personally relevant activities will improve community integration for Veterans with history of TBI and cognitive difficulties. Findings may guide rehabilitation training towards providing services to maximize success in attaining complex functional goals in which Veterans can engage in skill strengthening ‘where they are’ (any location). |
TATJANA NOVAKOVIC-AGOPIAN; | 2026-04-03 |
| 6 | YOGA-FIT: Protocol for A Crossover Trial Investigating The Feasibility and Impact of Yoga for People With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this mixed-methods pilot crossover study is to determine the feasibility (participant satisfaction, recruitment rate, participant and assessor burden, adherence, equipment and technology issues, and safety) of virtual and in-person LYB yoga for adult people with lived experience of stroke in Nova Scotia who are at least three months post stroke. The secondary objective is to estimate the efficacy of virtual and in-person yoga for improving balance, walking, mobility, mental health (anxiety and depression), and other health outcomes (pain, sleep, health perception, and falls). The tertiary objective is to estimate the extent to which cognitive function, fatigue, … |
ADRIA QUIGLEY; | 2026-03-12 |
| 7 | Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis Before and After Functional Electrical Stimulation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking. The L300 device is designed to help lift the foot during each step. This study will evaluate how using the L300 affects walking performance. Researchers will measure walking speed, step length, … |
EMILY ROSARIO; | 2026-03-27 |
| 8 | The Effect of Photobiomodulation on Heart Rate Variability in Healthy Adults Subjected to The Maastricht Acute Stress Test (MAST): A Sham-controlled, Within-subject Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Photobiomodulation (PBM) is a form of light therapy that uses red or near-infrared light to influence biological processes. In prior studies, PBM has been shown to improve various physiological functions, including tissue repair, inflammation, and cognitive performance. However, little is known about its impact on autonomic nervous system regulation. Thus, the goal of this study is to evaluate the effects of PBM on vagal activity, as measured by heart rate variability (HRV), in healthy adults undergoing experimental stress. |
PETER M. WAYNE; | 2026-03-17 |
| 9 | Veteran’s Interdisciplinary Care for Traumatic Brain Injury & Co-Occurring Disorders Rehabilitation Trial – A Pragmatic, Randomized, Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if the Avalon Action Alliance Interdisciplinary Outpatient Rehabilitation Program (IORP) can reduce long-lasting symptoms of traumatic brain injury (TBI) and co-occurring disorders in veterans and first responders. The main questions it aims to answer are: * Does a 3-week IORP reduce symptoms of long-lasting TBI and co-occurring disorders in military veterans and first responders? * Does the 3-week IORP improve life quality and function in military veterans and first responders? Researchers will compare the Control group to the Invention group to see if a 3-week of IORP reduced symptoms of TBI and co-occurring disorders in military veterans and first responders. Participants will complete the following activities. The items with an asterisk(\*) are not required or available at all sites. * Answer online survey questions about their TBI symptoms, life satisfaction, and life activities * Complete two blood draws\* * Complete two magnetic resonance imaging (MRI) brain scans\* |
MICHAEL MCCREA; | 2026-04-02 |
| 10 | Efficacy and Safety of 6Degrees MyMove Interactive Virtual Reality Compared to Passive Virtual Reality in Subacute Stroke and Traumatic Brain Injury Rehabilitation: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke and traumatic brain injury frequently result in persistent upper and lower limb motor impairment. While conventional rehabilitation improves outcomes, patient adherence and training intensity remain limiting factors. Immersive virtual reality (VR)-based therapy may enhance neuroplasticity by delivering high-intensity, task-oriented motor practice with enriched sensory feedback. This randomized controlled trial evaluates the efficacy and safety of the 6Degrees MyMove interactive VR system compared to passive VR exposure in individuals undergoing subacute inpatient rehabilitation after stroke or traumatic brain injury. Sixty participants will be randomized 1:1 to receive either interactive VR-based motor training or passive VR viewing, … |
RACHEL DANKNER; | 2026-03-02 |
| 11 | PAVE (Parallactic Visual-Field Enhancement) System for Treatment of Chronic Visual Field Loss PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a research study to evaluate the effectiveness of the PAVE (Parallactic Visual-Field Enhancement) System for the treatment of chronic visual field loss due to stroke, traumatic brain injury, … |
DEANN FITZGERALD; | 2026-04-02 |
| 12 | Non-Trauma Intervention to Treat Posttraumatic Stress Disorder (PTSD) for Veterans and Service Members Suffering From A Traumatic Brain Injury (TBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators want to test a treatment for posttraumatic stress disorder (PTSD) especially designed for military veterans and service members with mild or moderate traumatic brain injuries (TBI) and PTSD. The treatment will include individual psychotherapy sessions to manage PTSD. |
CINDY MCGEARY; | 2026-03-09 |
| 13 | Assessment of Traumatic Brain Injury Using Transcranial Magnetic Stimulated Evoked Potentials (TMS-EEG) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Patients evaluated at Penn Presbyterian Medical Center for traumatic brain injury (TBI), who sign the informed consent, will undergo assessment of electrophysiologic potentials evoked by transcranial magnetic stimulation (TMS), using the Delphi-MD device (QuantalX Neuroscience Ltd., Saba Israel). |
RAMON DIAZ-ARRASTIA; | 2025-10-02 |
| 14 | Traumatic Brain Injury – Efficacy of Steroids in Acute Vasogenic Edema PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to learn about the impact of dexamethasone treatment in traumatic brain injury patients with vasogenic edema in the second week after the trauma, administered in centers where this intervention has been considered to treat brain edema. The main question it aims to answer is: Does dexamethasone in a regimen of 8mg/8h for 5 days improve vasogenic edema in patients after 5 days of their trauma? Participants already receiving this treatment as part of their regular medical care in emergency settings, general wards, or ICU settings for TBI will be included, … |
ANDRES M. RUBIANO; | 2026-01-22 |
| 15 | Functional and Neurodevelopmental Outcomes Following Intensive Multimodal Neurorehabilitation in Pediatric Patients With Neurodevelopmental Disorders, Including Chromosomal Abnormalities PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program. The program is designed for children with neurodevelopmental disorders, including but not limited to cerebral palsy, autism spectrum disorder, developmental delay, hypoxic ischemic encephalopathy (HIE), and chromosomal or genetic abnormalities. Participants receive individualized therapy sessions for approximately 2.5 hours per day over a two week period. The intervention is not standardized but is tailored to each child’s specific needs and may include components such as sensory integration, motor planning, reflex integration, oculomotor training, executive functioning activities, communication support, … |
TINA CASOGLOS-ADAMOPOULOS; | 2026-03-25 |
| 16 | Duraplasty for Acute Traumatic Spinal Cord Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if a procedure called expansile duraplasty can improve recovery in adults who have experienced an acute traumatic spinal cord injury (SCI). The main questions it aims to answer are: * Does expansile duraplasty work to improve recovery in people with acute traumatic SCI? * How safe is the use of expansile duraplasty in people with acute traumatic SCI? Researchers will compare the strength, movement, … |
RAJIV SAIGAL; | 2026-03-13 |
| 17 | Exploring Cognitive Behavioral Therapy for Insomnia (CBT-I) in Mild Traumatic Brain Injury (mTBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will employ cognitive behavioral therapy for insomnia (CBT-I) among individuals with mild traumatic brain injury (mTBI) who experience sleep disturbances. The research aims to evaluate the effects of CBT-I on sleep, mTBI symptoms, and, in particular, the ability of individuals with mTBI to engage in their desired daily life activities. The main questions this study aims to answer are: 1. Does CBT-I positively impact symptoms of mTBI? 2. Does CBT-I improve functional performance in individuals with mTBI? |
SEPIDEH ZENOOZI; | 2026-02-18 |
| 18 | Investigating The Feasibility and Translational Therapeutic Benefits of Overground, Fully Immersive Virtual Reality (VR) Gait Rehabilitation Therapies for Individuals With Traumatic Brain Injury (TBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate a new virtual reality (VR)-based rehabilitation program designed to help individuals with traumatic brain injury (TBI) improve their walking abilities in real-world settings. By comparing immersive VR-assisted overground gait therapy to contemporary non-immersive, treadmill-based VR therapy (i.e., C-Mill), the investigators aim to determine its effectiveness in enhancing mobility and quality of life for TBI patients. |
HEE-TAE JUNG; | 2026-02-27 |
| 19 | Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Combat-related traumatic brain injury (cTBI), particularly blast-related injury, is frequently associated with the development of persistent and disabling chronic pain. This prospective observational cohort study aims to determine the incidence, phenotypes, and early predictors of chronic pain following mild to moderate combat-related TBI. Adults will be enrolled within 14 days of injury and followed for 6 months. The primary endpoint is clinically significant chronic pain at 3 months, defined by pain intensity and functional interference. The study will evaluate clinical, psychological, and physiological factors to develop and internally validate a prognostic model for chronic pain risk after cTBI. |
CHARITABLE ORGANISATION CHARITABLE FUND SUPERHUMANS CO CF SUPERHUMANS | 2026-02-24 |
| 20 | PIC Rehab: Psychologically Informed Cervicovestibular Rehabilitation for Mild Traumatic Brain Injury: A Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Mild traumatic brain injuries (mTBIs) affect over 480,000 Canadians each year. While many individuals recover in the initial 4 weeks following mTBI, in up to 30% of individuals symptoms and functional impairments often persist leading to significant disability, decreased quality of life and participation in education, physical and occupational related activities. An assessment that evaluates multiple systems is recommended for individuals with mTBI, often involving multiple health care professionals to assess different areas of function (e.g. oculomotor, vestibular, balance, mood, cognition, etc). Current evidence supports the use of cervicovestibular rehabilitation (CVPT) (which includes physiotherapy techniques aimed at treating the neck, … |
KATHRYN SCHNEIDER; | 2026-02-11 |
| 21 | A Multicenter Prospective Study to Develop A Blood-based Biomarker Test for Aiding The Diagnosis/Prognosis of Traumatic Brain Injury in Adult Subjects (CLIN12.1) and for Monitoring The Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury (CLIN12.2) PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The study is intended to cover two purposes: first, to develop a blood-based biomarker test for aiding the diagnosis of traumatic brain injury (TBI) in adult participants and for prognosis of outcome of TBI (CLIN12.1); and second, for monitoring the development of secondary events in adult participants diagnosed with TBI (CLIN12.2). |
HOFFMANN LA ROCHE | 2026-04-03 |
| 22 | The Örebro Severe Traumatic Brain Injury Registry (ÖrSBID): A Prospective Observational Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic brain injury and other severe brain injuries requiring neurointensive care are associated with high mortality, long-term disability and substantial societal burden. Despite advances in critical care, outcomes after severe brain injury remain difficult to predict and secondary brain injury plays a major role in determining prognosis. The Örebro Severe Brain Injury Database (ÖrSBID) is a prospective observational registry that aims to systematically collect detailed clinical, physiological, … |
ANDRÁS ZOLTÁN BUKI; | 2026-02-09 |
| 23 | Multi-institutional Phase 2/3 Trial of Fresh Frozen Plasma (FFP) in Patients With Moderate to Severe Traumatic Brain Injury (TBI) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn about treatment with fresh frozen plasma (FFP) in individuals with moderate to severe traumatic brain injury. The two main question\[s\]it aims to answer are: * Is the FFP treatment safe? * Does the FFP treatment impact the 24-hour, 3-month and 6-month outcomes, intensive-care free days, mortality, … |
HASAN ALAM; | 2026-02-11 |
| 24 | Hypersensitivity to Amylin in Post-Traumatic Headache: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Pramlintide is a peptide analogue of human amylin which is a vasoactive substance involved in the pathogenesis of headache. This study investigates whether pramlintide induces migraine-like headache in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI). |
KSENIJA CUCANIC; | 2026-01-14 |
| 25 | Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Part 3 – Option II PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if experimental drug treatment improves recovery after TBI as compared to a control (placebo) group. Changes in recovery will be measured throughout the study. The study drug listed below is approved by the U.S. Food and Drug Administration (FDA) but is being used off-label in this study. This means that the drug is not currently approved to treat TBI. |
GEOFFREY MANLEY; | 2026-01-26 |
| 26 | The Role of Transcutaneous Vagus Nerve Stimulation in Neuroprotection and The Reduction of The Systemic Inflammatory Response in Acute Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Acute brain injury is a major global health problem associated with high mortality and morbidity, limited therapeutic options, prolonged hospital stays, and long-term disability that significantly impairs quality of life and increases healthcare costs. Noninvasive transcutaneous VNS developed as a safer approach for treating cerebral edema, epileptic seizures, and blood-brain barrier disruption, for facilitating the recovery of motoric and cognitive functions, and for immunomodulation. Transcutaneous VNS improves cerebral perfusion pressure and tissue oxygenation, supports reperfusion of the penumbral zone, and reduces neuronal hyperexcitability, thereby suppressing seizures.It may exert anti-inflammatory effects by reducing microglial cytokine and chemokine production. Additionally, … |
DINKO TONKOVIĆ; | 2026-02-03 |
| 27 | Myofunctional Therapy for Obstructive Sleep Apnea in U.S. Service Members With and Without Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The overall purpose of this study is to compare changes in sleep outcomes in people with obstructive sleep apnea (OSA) depending on their participation in one of two behavioral interventions; both involve drinking water and breathing. A second purpose is to compare outcomes between people who have sustained a traumatic brain injury (TBI) and those with no history of TBI. The main questions it aims to answer are whether sleep quality improves after 3-months of high-resistance versus low-resistance exercises, and whether people have different outcomes depending on their history of TBI. |
NANCY P. SOLOMON; | 2026-02-17 |
| 28 | The Association Between Head Cooling and Cognition, Neuroinflammatory Cytokines, Menstrual Cycle, Sleep Patterns, Mental Health and Concussions PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This research is being done to examine the benefits of a 28 day head cooling intervention on cognition, inflammation of the brain, sleep quality, menstrual symptom interaction, and mood in acutely concussed females. Brain cooling has been shown to cause temporary symptom relief after traumatic brain injury, but its implications for decreasing timeline of full concussion recovery, particularly in females during periods of confounding neuropsychological menstrual symptoms, remains unexplored. |
OWEN GRIFFITH; | 2025-12-26 |
| 29 | Remote Stimulation and Training to Advance Recovery From TBI in Seniors PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI). The main questions are: * Does transcranial direct current stimulation (tDCS) make cognitive training more effective for improving attention, memory, and decision-making? * Is this type of home-based program feasible and acceptable for older adults with TBI? Researchers will compare two groups: one group will receive active tDCS during cognitive training, … |
CASEY GILMORE; | 2026-01-12 |
| 30 | Home-based Treatment of Binocular Eye Dysfunction in Veterans With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Post-concussive vision symptoms affect many Veterans who have experienced traumatic brain injury (TBI). One common issue is trouble with near vision, a problem that may persist long after the acute injury. Double vision or difficulty focusing on close objects can affect reading and depth perception. Poor reading can interfere with academic or work performance, and loss of near focusing can affect jobs that require fine motor tasks like machining and electrical work. Even having trouble using a smartphone can have a substantial impact on both work and social function. Near vision impairment after TBI is not well understood, … |
MARK F. WALKER; | 2026-01-20 |
| 31 | Effectiveness of The Traumatic Brain Injury Whole Blood Test on Improving Assessment and Triage for Patients With GCS 13-15 Presenting to Emergency Departments PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of this study is to identify determinants for implementing the i-STAT Alinity whole blood traumatic brain injury (TBI) test for its Food and Drug Administration (FDA)-indicated use and to evaluate other potential outcomes with clinical implications. The main questions it aims to answer are: 1. Determine the number of patients with non-elevated (i.e., below clinical cutoff) whole blood iSTAT Alinity tests who also receive CT scans. 2. What are the obstacles for using the i-STAT Alinity for its FDA-indicated use |
SHAWN EAGLE; | 2026-02-09 |
| 32 | Mild Cognitive Impairment and Psychopathology: Effects on Awareness, Social Life, and Work. Cross-sectional Observational Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Mild Cognitive Impairment (MCI) is a condition characterized by cognitive deterioration greater than what is expected from normal aging, representing an important risk factor for the development of dementia. Early assessment of cognitive functions is therefore essential for promptly identifying any signs of decline. In addition to cognitive aspects, it is equally important to consider the possible psychopathological profile of patients, as such disorders can significantly influence the progression of the disease, quality of life, and the ability to manage daily activities. This protocol aims to explore the presence of psychopathological disorders in patients with MCI, … |
IRENE CAPPADONA; | 2026-01-22 |
| 33 | Treatment Patterns, Medication Usage, Effectiveness, and Safety Among US Veterans Using The Remote Electrical Neuromodulation (REN) Wearable Device for Migraine Treatment PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Among US veterans, migraine is a prevalent and disabling neurological disorder, creating a clinical need for effective treatment options. This real-world evidence (RWE) study assessed the use, effectiveness, and safety of the REN wearable for the acute treatment of migraine among veterans, with a primary focus on whether they need rescue medications following REN treatment. Findings from this study may help guide clinical decision-making as veterans and providers craft treatment plans that include non-pharmacologic options. |
ALIT STARK-INBAR; | 2026-04-03 |
| 34 | Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a Phase II, randomized, quadruple-blinded, placebo-controlled clinical trial designed to test whether vitamin D₃ supplementation can improve recovery after mild-to-moderate traumatic brain injury (TBI) in adults. Traumatic brain injury often leads to inflammation and poor neurological outcomes, and many patients are vitamin D-deficient. Vitamin D₃ is a safe, widely available supplement that may reduce inflammation and support brain recovery. A total of 240 adults (18-65 years) with mild-to-moderate TBI will be enrolled at Lagos State University Teaching Hospital, … |
OLUFEMI IDOWU; | 2025-12-15 |
| 35 | Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention in The WarfiGHTer (INSIGHT) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The INSIGHT study is a multi-site clinical research program designed to examine how insomnia and symptoms of sympathetic hyperactivity impair sleep, cognition, and physiological restoration in warfighters, and to evaluate whether a wearable therapeutic device can improve these outcomes. Warfighters with a history of traumatic brain injury, post-traumatic stress disorder, or chronic operational stress commonly report disrupted sleep accompanied by manifestations of nocturnal sympathetic activation such as diaphoresis, palpitations, hyperarousal, and nightmares. These symptoms erode sleep quality, reduce cognitive performance, … |
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES | 2025-12-17 |
| 36 | Neuroprotective Effect of Mild Hypothermia As Compared With Normothermia During Cardiopulmonary Bypass of Coronary Artery Bypass Grafting – A Single-center Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In high-income countries, coronary artery bypass grafting (CABG) remains a common procedure, with approximately 36.7 operations per 100,000 inhabitants annually, corresponding to about 136,000 procedures in the European Union. This highlights the substantial healthcare burden and the need to optimize surgical outcomes. Cardiopulmonary bypass (CPB) is a fundamental component of cardiac surgery, ensuring extracorporeal perfusion of vital organs. Hypothermic CPB has historically been widely used for organ protection due to its presumed neuroprotective mechanisms. However, evidence demonstrating its superiority over normothermic CPB remains inconclusive. In its 2024 guidelines, … |
TIMO LAITIO; | 2026-01-05 |
| 37 | Effect of Interdisciplinary Interventions After Mild Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators aim to investigate the impact of interdisciplinary and individually tailored programs for mTBI (concussion) on quality of life and work capacity, both at the conclusion of the program and after 1 and 3 years. The investigators also want to examine whether early intervention is significant by comparing individuals who enter the program between 1 and 3 months post-concussion with those who only start the program more than 9 months post-concussion. Such a study has not been conducted before and can provide valuable insights into long-term effects and the importance of early intervention |
RUNE SKOVGAARD RASMUSSEN; | 2025-08-12 |
| 38 | EarLy Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT): A Parallel Group, Randomized, Double Blind, Placebo Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Most individuals with mild traumatic brain injury (mTBI) experience post-traumatic headaches (PTH). Of PTH, 50% present with a migraine phenotype which is the most disabling type of PTH. Patients with migraine-PTH are at greater risk of persistent symptoms whereby the acute PTH (aPTH) becomes persistent PTH (pPTH) (ie. lasting \> 3 months) with a conversion rate of 47-95%. As migraine symptoms become chronic, it becomes treatment resistant. Despite these implications, early preventive medication management of PTH is marred by lengthy trials of multiple medications (2-3 months for each) and adverse effects that aggravate mTBI symptoms (fatigue, nausea, … |
HOWARD MENG; | 2025-12-29 |
| 39 | Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Pilot Cohort Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary goal of this proposal is to improve the understanding of the mechanisms causing persistent pain and disability in elbow fracture patients and their associated functional limitations. The specific objectives are as follows for elbow fractures: 1\) To describe NI mechanisms using biomarkers; 2) To identify factors related to increased NI biomarkers level; 3) To describe the associations between NI and outcomes; … |
DOMINIQUE ROULEAU; | 2025-12-02 |
| 40 | An Efficacy and Feasibility Trial of A Portable Near Infra-Red Hematoma Imager for Detection of Intracranial Hemorrhage in The Acute Care Setting PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic Brain Injury (TBI) is a leading cause of death and disability among military personnel, Veterans, and civilians. One of the most dangerous complications of moderate-to-severe TBI is intracranial hemorrhage (ICH). If not identified and treated promptly, ICH can rapidly lead to worsening neurological damage or death. Current diagnostic tools, such as CT scans, are highly effective but impractical for battlefield or resource-limited environments due to their large size and infrastructure dependency. The Near-Infrared Detection-Head Imaging (NIRD-HI) system is an innovative, noninvasive device using Near-Infrared Spectroscopy (NIRS) to identify abnormal blood accumulation. Unlike traditional tools, NIRD-HI is compact, lightweight, … |
JULIE RIZZO; | 2026-01-13 |
| 41 | Transcranial Photobiomodulation in Older Adults With Traumatic Brain Injury: Effects on Cerebral Blood Flow and Cognition PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the effect of transcranial photobiomodulation (tPBM) in older patients with chronic traumatic brain injury (TBI). The study aims to examine the effect of tPBM on prefrontal cerebral blood flow (CBF) and executive function (EF) |
TAMARA BUSHNIK; | 2026-01-15 |
| 42 | A Multicenter, Randomized, Controlled Study to Evaluate The Efficacy and Safety of The SSMD in Neuromotor Rehabilitation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a multicenter, randomized, controlled clinical study evaluating the safety and effectiveness of the Spatial StimelMD (SSMD) device for upper-limb neuromotor rehabilitation in adults with impairment following stroke or traumatic brain injury (TBI). Participants will be randomized to receive either SSMD therapy plus standard rehabilitation care or standard functional electrical stimulation (FES) plus standard care. Subjects will complete approximately 25 supervised treatment sessions over 5-6 weeks, with assessments at baseline, mid-treatment, post-treatment (primary endpoint), … |
BORIS CHELIBIAN; | 2026-02-11 |
| 43 | Evaluation and Enhancement of The Effectiveness of Non-invasive Intracranial Pressure Monitoring for Screening in Neurological Emergencies Within The Brazilian Unified Health System PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to evaluate the diagnostic accuracy of non-invasive intracranial pressure (ICP) and intracranial compliance (ICC) pulse morphology and associated parameters (such as the P2/P1 ratio and nTTP) obtained with the brain4care system for the screening of intracranial hypertension (ICH) in patients with traumatic brain injury (TBI) and stroke treated in Brazil’s public health system (SUS). The main questions it aims to answer are: Can non-invasive ICP and ICC pulse morphology reliably identify or exclude intracranial hypertension, cerebral edema, … |
ROBSON L OLIVEIRA DE AMORIM; | 2025-10-07 |
| 44 | Passive Neurosensory Reintegration Training As A Tool to Augment Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Mild traumatic brain injury (mTBI) poses a substantial clinical and public health burden, often leading to persistent neurosensory and cognitive symptoms for which diagnostic and therapeutic solutions remain limited. This study proposes a multimodal diagnostic framework that integrates established mTBI screening tools and clinical neuro-optometric assessments with high-resolution oculomotor, vestibular, and reaction time (OVRT) testing to enhance diagnostic precision and identify prognostic markers of recovery. Normative data will be established in healthy controls to inform objective thresholds and support clinical implementation. Concurrently, we will evaluate the safety, tolerability, and preliminary efficacy of a novel, minimal-risk multisensory therapeutic intervention (i.e., … |
ERIN WILLIAMS; | 2026-01-21 |
| 45 | Dementia and Mild Cognitive Impairment: Assessment of Cognitive Functioning, Functional Autonomy, and Neuropsychiatric Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Dementia, in its various forms, is characterized by a generalized cognitive decline that can significantly compromise personal autonomy and quality of life. Mild Cognitive Impairment (MCI), although not classified as an overt form of dementia, represents a condition at evolutionary risk and is considered a crucial transitional stage for the early detection of cognitive decline. Understanding the impact of dementia and MCI from a multidimensional perspective is now essential to fully grasp the repercussions of these conditions on patients’ daily lives. The present protocol aims to investigate key aspects related to these disorders, with the objective of exploring cognitive functioning, … |
FRANCESCO CORALLO; | 2025-12-17 |
| 46 | High-Flow Oxygen Therapy Via Tracheal Intubation in Neurocritical Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Neurocritical patients often require prolonged invasive ventilation due to impaired respiratory drive and airway protection deficits. While early weaning reduces complications and costs, these patients frequently pass spontaneous breathing trials (SBT) yet remain intubated solely for airway protection. Current practice maintains low-level pressure support ventilation (5-8 cmH₂O) to offset endotracheal tube resistance. However, prolonged ventilation increases risks of ventilator-associated pneumonia (VAP) and diaphragm dysfunction. Emerging evidence suggests appropriately sized tubes may not substantially increase work of breathing (WOB). High-flow oxygen therapy (HFOT) delivers heated, humidified oxygen at high flow rates, … |
CHEN GUANGQIANG; | 2025-12-02 |
| 47 | Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for The Treatment of Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of traumatic brain injury |
CHADWICK PRODROMOS; | 2025-04-17 |
| 48 | Effects of Moderate/Severe Traumatic Brain Injury in The Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: While clinical assessment of locomotor function in this population is carried out using tasks involving walking in a straight line without any obstacles, it does not take into account ecological situations (i.e., situations comparable to real-life situations) in which the person interacts with their environment, such as walking down a street with other pedestrians, … |
PÔLE SAINT HÉLIER | 2025-11-17 |
| 49 | Effects of Transcutaneous Cervical Spinal Cord Stimulation on Upper Limb Motor Function After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this study is to test the effects of non-invasive electrical stimulation of the spinal cord (called transcutaneous spinal cord stimulation, or tSCS) on arm and hand movement in people with motor impairments after a traumatic brain injury (TBI). Specifically, tSCS will be delivered using adhesive electrode pads placed on the skin over the upper back. The research team will measure how tSCS affects strength, movement control and muscle spasticity using different tests. Results of this study will help develop future treatments using an implanted (invasive) form of spinal cord stimulation to improve arm and hand function, … |
ROBERTO DE FREITAS; | 2026-02-09 |
| 50 | Hypnosis and Attention in Patients With A Neurological Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This feasibility study investigates the potential of hypnosis as a complementary therapy to improve attentional deficits and fatigue in patients with neurological diseases such as stroke, traumatic brain injury (TBI), and multiple sclerosis (MS). These patients often experience reduced spontaneous visual exploration and impaired functional independence despite current rehabilitation methods. By integrating hypnosis with standard care, and using EEG to monitor brain activity during hypnosis and sham-hypnosis sessions, this trial aims to evaluate the practicality, acceptability, and preliminary efficacy of hypnosis in enhancing attention and reducing fatigue. |
LUZERNER KANTONSSPITAL | 2025-12-01 |
| 51 | Identification and Risk Assessment of Mild Traumatic Brain Injury (mTBI) in Czech Armed Forces Soldiers During Specific Training Activities PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study will utilize both diagnostic biomarker analysis and experimental biomechanical measurements to assess the physiological impact of these activities on brain health. The ultimate goal is to reduce mTBI incidence, improve operational readiness, and extend the active service duration of soldiers through targeted preventive measures. |
MICHAL SOTÁK; | 2025-11-19 |
| 52 | Parent-Child Interaction Therapy (PCIT) for Children With Traumatic Brain Injury (TBI): A Stepped-Care Model PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to understand how a stepped-care model of Parent-Child Interaction Therapy (Step-Up PCIT) addresses child behavioral problems among children between the ages of 2 and 7 with a traumatic brain injury (TBI). |
DAINELYS GARCIA; | 2025-08-26 |
| 53 | PRophylaxis Against Early VENTilator-associated Infections to Reduce Mortality in Mechanically Ventilated Intensive Care Unit (ICU) Patients With Acute Brain Injuries: A Phase 3 Randomised, Double Blind, Parallel Group, Placebo-controlled Two-side Superiority Trial PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when they have been admitted to hospital with an acute severe brain injury. An acute severe brain injury can occur as a result of a stroke, a traumatic injury or due to lack of oxygen to the brain that happens as a result of a cardiac arrest. Patients who are unconscious after an acute severe brain injury often need assistance to breath adequately, … |
ANDREW UDY; | 2026-02-19 |
| 54 | Differences in C-Reactive Protein Levels Between Traumatic Brain Injury Patients Receiving Dexmedetomidine and Those Not Receiving Dexmedetomidine Undergoing Craniotomy at Prof. Dr. Margono Soekarjo Regional General Hospital, Purwokerto PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic Brain Injury (TBI) is a major cause of morbidity and mortality and is often associated with a systemic inflammatory response after surgery. C-reactive protein (CRP) is a commonly used biomarker to assess inflammation. Dexmedetomidine is an anesthetic adjuvant that may have anti-inflammatory effects. This study aims to compare C-reactive protein levels in traumatic brain injury patients undergoing craniotomy who receive dexmedetomidine with those who do not receive dexmedetomidine. The study is conducted at Prof. Dr. Margono Soekarjo Regional General Hospital, … |
ADRIAN NUGRAHA PUTRA; | 2026-02-17 |
| 55 | Feasibility RCT of An Adapted Cognitive Rehabilitation Program for Refugees and Asylum Seekers With TBI and Cognitive Impairment PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Researchers at Massachusetts General Hospital are looking to see if a program created to help improve thinking and memory can work for refugees with traumatic brain injury (TBI). They’re checking if this program is practical and if people find it helpful. The study will have two groups. Participants will complete a first questionnaire and then be assigned to a group by chance. One group will participate in the program immediately and then answer the second questionnaire (approximately 3 months after the first questionnaire they did). Then they will wait and then answer the third and final questionnaire approximately 6 months after the first one. The second group will wait and answer the second questionnaire approximately 3 months after the first one. Then they will receive the program and answer the third and final questionnaire (approximately 6 months after the first one they did.) |
ALTAF SAADI; | 2026-03-11 |
| 56 | Shared Subcortical Arousal Systems Across Perceptual Modalities PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study is a multi-site study and will be conducted at up to 11 investigative sites in the United States. The study will investigate subcortical arousal circuits in visual perception using techniques with complementary strengths based on promising initial studies. |
HAL BLUMENFELD; | 2026-04-02 |
| 57 | A Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate The Efficacy and Safety of Methylprednisolone Sodium Succinate Injection in Patients With Moderate to Severe Traumatic Brain Injury PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to learn if standard-dose methylprednisolone sodium succinate can improve neurological recovery and safety in adults with moderate to severe traumatic brain injury (TBI). The main questions it aims to answer are: 1. Does adding a 5-day course of methylprednisolone improve overall long-term neurological outcome compared with placebo? 2. Does methylprednisolone reduce 6-month mortality or increase the proportion of patients with good neurological recovery? 3. What medical problems do participants experience when receiving methylprednisolone? Researchers will compare methylprednisolone sodium succinate (2 mg/kg/day intravenously for 5 days) with a matching placebo to see if the steroid improves outcomes beyond standard TBI care. Participants will: 1. Receive either methylprednisolone or placebo once daily for 5 days, added to guideline-directed standard care. 2. Undergo CT scans and neuro-examinations during hospitalization. 3. Return for follow-up visits at 1 month and 6 months after injury for neurological assessments, safety checks, and questionnaires. |
RONG GAO; | 2025-09-18 |
| 58 | Viscoelastic Tests (VET) Versus Conventional Coagulation Tests (CCT) for Management of Trauma-Induced Coagulopathy: Opened, Randomized, Two-Parallel, Controlled Trial.VISCOTAC PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic coagulopathy is a complex, multifactorial event that occurs in 20-30% of patients on admission. It increases mortality, and its treatment is one of the main priorities in the early management of severely injured patients. Diagnosis of coagulopathy has traditionally been based on conventional coagulation tests (CCTs), which provide an assessment of patients’ coagulation in over 60 minutes. Over the past fifteen years, viscoelastic tests (VETs) have been proposed, providing a more rapid result (≤ 10 min) and can guide the administration of labile blood products (LBP). Various studies, mainly retrospective, … |
GUILLAUME BOUHOURS; | 2025-07-11 |
| 59 | Neuropsychiatric Outcomes and Disrupted Sleep Following Acquired Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The two most common causes of brain injury are stroke and trauma. Both sleep and mental health problems are common after brain injury; we will investigate whether there is a relationship between poor sleep quality and worse mental health in this group. We will also follow patients up, at approximately three-monthly intervals until one year after injury, to see how sleep and mental health symptoms change over time and with recovery. We will assess sleep in detail using questionnaires, a sleep monitor worn on the wrist, a portable brain activity sensor, … |
MELANIE FLEMING; | 2025-10-10 |
| 60 | Using High Definition Transcranial Direct Current Stimulation to Treat Verbal Retrieval Deficits Secondary to Chronic Traumatic Brain Injury (STIM-CTBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI). The type of brain stimulation used is called transcranial direct current stimulation (tDCS). tDCS delivers low levels of electric current to the brain and high definition tDCS (HD-tDCS) delivers the current with multiple electrodes on the scalp. This current is delivered with HD-tDCS to parts of the brain that may help with remembering things. The investigators hope that this can help to improve word finding and memory problems in people with TBI. |
HSUEH-SHENG CHIANG; | 2025-10-21 |
| 61 | Clinical Feasibility & Validation of The Augmented Reality-Delivered GlenxRose Programs for Acquired Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Factors related to successful rehabilitation in acquired brain injury (ABI) are often directly related to adherence; for instance, dosage, frequency, and intensity can burden the patient regarding time and motivational factors. Regarding salience, patients may lose interest or find a traditional intervention boring after a few sessions. It is well documented that nonadherence not only impacts rehabilitation for patients but can also further prolong treatment, and increase hospital and clinician costs, in addition to a higher prevalence of future comorbidities. Additionally, the same factors that are related to can impact adherence are also related to neuroplasticity. Therefore, … |
UNIVERSITY OF ALBERTA | 2025-09-17 |
| 62 | Immersive Functional Virtual Reality in People With Acquired Brain Injury and Unilateral Spatial Neglect: A Feasibility and Usability Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Unilateral spatial neglect (USN) is a common and highly disabling condition following acquired brain injury (ABI), significantly impairing individuals’ ability to perform daily activities and reducing their autonomy. It frequently affects patients who have suffered a stroke or traumatic brain injury, and it is often associated with worse functional outcomes and increased care needs. Despite advances in neurorehabilitation, conventional assessment and treatment tools for USN have shown limitations in sensitivity and ecological validity. Immersive Functional Virtual Reality (IFVR) is an emerging and promising technology that creates controlled, interactive environments, … |
JOSAN MERCHAN; | 2025-06-12 |
| 63 | Role of Non-Selective Beta-Adrenergic Blocker in Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The role of nonselective beta adrenergic blocker as antistress agent in severe traumatic brain injury |
HUDA TALAAT IBRAHIM ELKALLAF; | 2025-03-11 |
| 64 | Prevalence of Neurodevelopmental Disorders in A Homeless Population – Pilot Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Introduction \& Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder). Methods / approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, … |
CAROLINE DEMILY; | 2025-08-01 |
| 65 | Feasibility of Unsupervised Therapy After Neurological or Orthopaedical Injury in The Home Setting With A Hand Rehabilitation Device (ReHandyBot) and An Assistive Smartphone Application (RehabCoach): An Exploratory Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to evaluate whether using the ReHandyBot hand rehabilitation device together with the RehabCoach smartphone app can support safe, independent, and effective home therapy in patients with stroke, traumatic brain injury, … |
OLIVIER LAMBERCY; | 2025-09-19 |
| 66 | Evaluation of Functional and Biochemical Effectiveness of A Strength Training Protocol in Parkinson’s Disease PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Parkinson’s Disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, which results in a range of motor symptoms such as tremor, rigidity, and bradykinesia, as well as non-motor symptoms including anxiety, depression, and cognitive decline. Strength training has emerged as a promising intervention to improve motor function and influence biochemical markers associated with oxidative stress and neurodegeneration. This study aims to evaluate the effectiveness of a structured strength training protocol over 12 weeks in improving both functional and biochemical outcomes in patients with PD. |
NOELIA DIAZ LOPEZ; | 2025-07-31 |
| 67 | Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive well-being and have been linked with early neurodegeneration. PPCS include somatosensory (e.g., headache, disturbed vision), vestibular (e.g., dizzy, clumsy), cognitive (e.g., executive function, memory) and affective symptoms (e.g., sleep disturbance, irritability, … |
JAMES BURCH; | 2025-09-17 |
| 68 | Single-center Transversal Observational Study on The Evaluation of S100B Changes in Subjects Attending The Emergency Department With Head Trauma PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of the study is to evaluate blood levels of the calcium-binding protein S100B as a diagnostic biomarker for the management of patients with suspected traumatic brain injury. With a sensitivity of 97% and a negative predictive value greater than 99%, S100B measurement can predict the absence of brain injury, supporting risk stratification and the safe discharge of low-risk patients. This, in turn, … |
MASSIMO LOCATELLI; | 2025-09-24 |
| 69 | An Exploration of The Relationship Between Sleep Disturbance, Mental Health, and Functional Outcomes in Mild, Moderate and Severe Traumatic Brain Injury (TBI): A Mixed Methods Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to look at how sleep disturbance affects people who have had a traumatic brain injury. Sleep disturbance can include waking frequently in the night, difficulty falling asleep, excessive sleepiness or changes to usual sleep patterns. Investigators define traumatic brain injury as an injury caused by a forceful bump, blow, or jolt to the head or body, or from an object entering the brain. This results in a disturbance of normal brain function, that can be temporary. By understanding the relationship between sleep disturbance and traumatic brain injury, … |
UNIVERSITY OF NOTTINGHAM | 2025-08-13 |
| 70 | Point of Care Testing in Emergency Departments After Mild Traumatic Brain Injury (POCkET) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic brain injury (TBI) is estimated to have the highest incidence of all common neurological disorders, affecting 50 to 60 million people worldwide each year. In the UK, approximately one million people attend an Emergency Department (ED) annually following a head injury, and 80-90% of these are classified as mild TBI (mTBI), also referred to as concussion. In the acute setting, mTBI is typically defined by a Glasgow Coma Scale (GCS) score of 13-15 on presentation. Current acute management focuses primarily on identifying which patients require a CT head scan to detect life threatening injuries that may need neurosurgical intervention, … |
VIRGINIA NEWCOMBE; | 2025-08-19 |
| 71 | A Pilot Study in Defining The Potential of Transcranial Alternating Current Neuromodulation for Stabilizing Memory and Improving Functional Connectivity in Neurodegeneration PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states. Transcranial alternating current stimulation (tACS) has been suggested as a promising, non-invasive, method of normalizing network connectivity and hence improving cognition, notably memory. This study will examine the efficacy of tACS at improving working memory performance in patients with neurodegeneration and its correlation to changes in network connectivity, based on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) imaging data. |
BOJANA STEFANOVIC; | 2025-03-13 |
| 72 | Multidimensional Sleep Health Intervention to Optimize Concussion Recovery: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Following adolescent concussion, poor sleep health is common and relates to the development of persisting post-concussion symptoms, and uninjured adolescents (independent of concussion) also commonly experience sleep insufficiency. Given the sparse guidance that exists for clinicians to provide evidence-based sleep health recommendations for adolescents with a concussion, the primary objectives of this prospective randomized clinical trial of adolescents with a recent concussion are to discover if a multidimensional and prescriptive sleep health intervention leads to: 1) faster symptom resolution time, better sleep quality, or longer sleep duration; and 2) improved sleep habits, mental health, or academic engagement, … |
DAVID R HOWELL; | 2025-07-24 |
| 73 | Transcutaneous Spinal Stimulation and Gait Training to Improve Mobility and Motor Control in Individuals With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this research study is to assess the effects of receiving transcutaneous spinal stimulation while performing walking exercises compared to completing walking exercises without spinal stimulation for individuals with hemiplegic TBI. |
KAREN J. NOLAN; | 2025-09-02 |
| 74 | Trifecta Research Study: Examining Hormone Replacement Therapy, Magnetic E-Resonance Therapy, Ibogaine, and 5-MeO-DMT in The Treatment of Posttraumatic Stress Disorder and Traumatic Brain Injury-related Cognitive Symptoms Related Papers Related Patents Related Grants Related Experts Highlight: The Special Operations Care-Fund (SOC-F) will sponsor the application of four treatments – hormone replacement, magnetic resonance brain stimulation, ibogaine, and 5-Meo-DMT – to Special Operations Forces veterans with a history of combat deployments, traumatic brain injury, and problems with mental health and cognitive functioning. An observational study will be conducted in parallel by the Johns Hopkins Center for Psychedelic and Consciousness Research to determine the effectiveness and safety of each treatment, primarily through measuring post-treatment changes in PTSD symptoms and cognitive functioning. |
SANDEEP NAYAK; | 2025-08-22 |
| 75 | Protocol for Developing and Validating A Multimodal Brain Monitoring-Based Prognostic Model for Neurocritical Patients: A Prospective, Observational, Multicenter Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help predict 90-day outcomes (awake, comatose, or deceased) and support personalized treatment decisions. The study is observational and involves no experimental interventions. |
XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY | 2025-08-11 |
| 76 | Use of Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness: A Pilot Feasibility Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Prolonged disorders of consciousness (pDOC) are defined as DOC lasting \>1 year post injury for patients with Traumatic Brain Injury (TBI) and \>3 months post injury for patients with non-TBI and at present there are limited treatments that reliably lead to enhanced prognosis. The rehabilitation process throughout the continuum of care for patients with pDOC necessitates restorative strategies to facilitate arousal and functional recovery and coordinated medical management. Rehabilitation interventions for patients with DOC and pDOC have evolved in the past decade, … |
JENNA MANCUSO; | 2025-09-19 |
| 77 | Effectiveness of Recruitment, Retention Strategies, and Data Collection Quality: A Feasibility Study in Combat Athletes With Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The use of Hyberbaric Oxygen Therapy (HBOT) would be a new treatment plan rather than conventional rest. If effective, this new use technology would add to the clinical treatment among mild traumatic brain injury (mTBI) patients. The use of a point of care Glial Fibrillary Acidic Protein (GFAP) biomarker would aid in clinical decision making to create a new care plan of return to sport among unarmed combat athletes who suffer from mTBI. The innovation would be a new treatment and diagnosis strategy that will protect these athletes from serious long-term sequelae. There are no published randomized controlled studies using HBOT to treat concussed athletes within one week of injury. There are no published studies using GFAP levels to predict post concussive symptoms (PCS). |
MICHAEL HARL; | 2025-08-13 |
| 78 | The Efficacy of Xeomin As A Prophylactic Therapy for Migraine in Patients With Traumatic Brain Injuries (TBIs) Versus Anomalous Health Incidents (AHIs) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI). The study will be conducted at the National Intrepid Center of Excellence (NICOE) in Bethesda, MD. The primary objective is to determine if Xeomin injections result in different outcomes for migraine management between TBI and AHI patients. This is a combined retrospective and prospective cohort study design. Patients scheduled for Xeomin treatments will be categorized into TBI and AHI groups. For the prospective cohort, … |
DAVID BRODY; | 2025-12-05 |
| 79 | Effectiveness of A Tidal Model-Based Nursing Approach for Caregivers of Individuals With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Brain injury is a broad concept that may develop as a result of head trauma or surgical interventions, vascular injuries (such as subarachnoid hemorrhage or stroke), metabolic or toxic causes, cerebral anoxia, inflammation, or infection. A meta-analysis conducted between 1990 and 2016 reported an annual incidence of 43.6 million cases of brain injury worldwide. According to data published by the Turkish Statistical Institute in the same year, 24.3% of deaths in Türkiye were attributed to cerebrovascular events. Although advances in emergency medical services and palliative care have increased survival rates, a substantial proportion of survivors experience significant physical, cognitive, emotional, … |
YASIN DEMIR; | 2026-04-02 |
| 80 | Neuromodulation-Enhanced Use of RObotic Balance Training to Improve Postural Control in Individuals With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Our proposed study, \"NEUROBALANCE,\" aims to evaluate the effectiveness of a combined intervention involving robotic balance training and noninvasive brain stimulation in improving balance functions in individuals with chronic traumatic brain injury (TBI). The study will recruit 45 participants who have had a TBI for over six months and experience persistent balance deficits. Participants will be randomized into three groups: (1) robotic balance training with active brain stimulation, (2) robotic balance training with sham brain stimulation, and (3) standard-of-care rehabilitation. The study will involve 12 training sessions over four weeks, with assessments conducted at baseline, post-training, … |
VIKRAM SHENOY HANDIRU; | 2025-08-06 |
| 81 | Hypersensitivity to Adrenomedullin in Post- Traumatic Headache: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Adrenomedullin is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether adrenomedullin induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI). |
HAIDAR AL-KHAZALI; | 2025-07-30 |
| 82 | Evaluating Two Novel Near-infrared Spectroscopy Devices for Non-invasive Monitoring of Traumatic Brain Injury in The Neuro Critical Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This project seeks to evaluate the capabilities of new Near Infrared Spectroscopy (NIRS) devices, which use light to measure brain activity, for monitoring how the brain and body react after a serious head injury (TBI), particularly in the immediate and shortly following periods. Data recorded from these devices will help determine if they can effectively monitor additional complications and outcomes in adults over 18 with severe TBIs in a specialised intensive care unit for brain injuries (NCCU) at Addenbrooke’s Hospital (Cambridge, … |
PETER J. HUTCHINSON; | 2025-08-06 |
| 83 | Assessing Phenytoin and Levetiracetam Efficacy, Cost-Effectiveness, and CYP2C9/SV2A Polymorphism in Early Post-Traumatic Seizures: A Multicentric Prospective Randomized Trial PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: Rationale/gaps in existing knowledge: The prophylaxis for post-traumatic seizures (PTS) remains controversial due to a lack of class I evidence. Investigators plan to conduct a high-quality, prospective, multicentric, randomized study regarding seizure prophylaxis in traumatic brain injury (TBI) with phenytoin, levetiracetam, and the placebo in three respective treatment groups, along with the effect of drug polymorphism on seizure occurrence. Novelty: Literature is scarce regarding the ideal management of early PTS in traumatic brain injury (TBI), a major public health problem. Further, … |
JASKARAN SINGH GOSAL; | 2025-08-06 |
| 84 | BLOOD BIOMARKERS TO IMPROVE MANAGEMENT OF MILD TRAUMATIC BRAIN INJURY IMPLIMENTACIÓN STUDY PF:5 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to evaluate the real-world applicability and clinical added value of a new management pathway for patients presenting to the emergency department (ER) with mild traumatic brain injury (mTBI). The pathway includes the use of the VIDAS® TBI in vitro diagnostic assay, … |
ALFONSO LAGARES GÓMEZ-ABASCAL; | 2025-12-31 |
| 85 | A Prospective, Non-randomized, Sequentially-enrolled, Multi-center, Phase II Study to Evaluate The SENSE Device’s Ability to Detect Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study population will consist of 3 mutually-exclusive sets of patients and subjects: * TBI patients with intracranial bleeding * TBI patients without intracranial bleeding * Control subjects with normal brain health. Research subjects ages 22 and older will be enrolled. All TBI patients must be monitored with the SENSE Device within 6 hours of a diagnostic head CT scan ordered by a treating clinician and within 24 hours of injury. |
JASON MCMULLAN; | 2025-11-25 |
| 86 | A Comparative-effectiveness Study on Expansion Craniotomy Versus Decompressive Craniectomy for Surgical Management of Traumatic Brain Injury in Patients With Intracranial Compartment Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic brain injury (TBI) patients often exhibit an increase in their intracranial volume due to blood collection or brain tissue edema. When the volume of any intracranial compartment exceeds a critical threshold, the compensatory mechanisms become exhausted, compromising intracranial compliance and blood supply, which leads to intracranial compartment syndrome (ICCS). The presence of this condition exacerbates brain damage through secondary injury. When less invasive measures to counteract ICCS prove to be insufficient, cranial decompression is recommended, with decompressive craniectomy (DC) being the preferred technique. Although its effectiveness has been demonstrated, … |
ANDRES M. RUBIANO; | 2025-05-08 |
| 87 | A Comparative Effectiveness Study on Catheter Locking Device Versus Standard Ventriculostomy for Surgical Management of Traumatic Brain Injury Patients With Intracranial Compartment Syndrome PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to compare the effectiveness and safety of a standard intervention called ventriculostomy for managing increased intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI). Elevated ICP is a critical condition that can result in brain damage or death if not treated promptly. The intervention will be performed in a traditional standard way or with an additional device called a catheter locking system. The first approach, standard ventriculostomy, involves placing a catheter into the brain’s ventricular system to drain cerebrospinal fluid (CSF), … |
ANDRES M. RUBIANO; | 2025-05-08 |
| 88 | Evaluation of Decision-Making Fatigue After Traumatic Brain Injury (EDIFY) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls. |
DAVID DARROW; | 2025-08-05 |
| 89 | BRAIN-SPEED-VETS: Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain’s excitatory/inhibitory (E/I) balance. This pilot project investigates this phenomenon by leveraging electroencephalography (EEG) to measure parietal lobe alpha rhythms during visual attention tasks. The hypothesis is that targeted visual attention training can modulate these alpha rhythms, improving instrumental activities in daily life. However, outcomes from such training vary, possibly due to individual differences in cortical inhibitory functions. This study will assess the relationship between EEG measures of E/I balance pre- … |
KEITH MCGREGOR; | 2025-08-29 |
| 90 | Personalized Accelerated Theta Burst Transcardial Magnetic Stimulation in Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Persistent post-concussive symptoms (PPCS) involve an array of physical, cognitive, and behavioral symptoms lasting more than a month after mild traumatic brain injury (mTBI). 34-44% of people with mTBI or concussion present with a considerable burden of PPCS 3-6 months after injury. There is currently no standardized treatment for PPCS, nor FDA approved medication for any neuropsychiatric or neurocognitive symptoms associated with mTBI. Transcranial magnetic stimulation (TMS) shows promise as a treatment for PPCS; however, … |
BHAVANI KASHYAP; | 2025-07-15 |
| 91 | Comparison Between The Effects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients With A Traumatic Brain Injury Admitted to The Intensive Care Unit PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic brain injury is a serious and common medical condition that often requires admission to the intensive care unit and the use of mechanical ventilation. One of the most frequent and challenging complications in these patients is the development of delirium and agitation. These symptoms can prolong hospitalization, increase the risk of further brain injury, … |
MOHAMED EL-SAYED ABDELGHANY NASEF; | 2025-05-28 |
| 92 | Comparative Study of Action Observation Training Versus Task Oriented Training on Reaching in Patients With Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Stroke is characterized by a sudden onset of localized or generalized brain dysfunction, with symptoms persisting for at least 24 hours or resulting in death. In the chronic phase following a stroke, hand dysfunction is commonly observed, often characterized by reduced finger strength and abnormal hand flexion patterns. Reaching is a crucial aspect of daily tasks, including activities like drinking, interacting with a touch screen, or pressing elevator buttons. |
AHMED ALSHIMY; | 2025-08-27 |
| 93 | Saline Vs. Balanced Crystalloid in Traumatic Brain Injury PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to determine which crystalloid (saline or balanced) should be used in the critical management of Traumatic Brain Injury (TBI) in moderate or severe TBI patients. This trial will determine whether the use of saline or balanced crystalloids is associated with improved outcomes in TBI patients. Participants will 1. be given fluids through the veins, either saline or balanced fluid will be given. 2. From the first day to the day 14 of the hospitalization (or discharge, whichever comes first), vital signs, laboratory values, treatments given, … |
AKSHITKUMAR MISTRY; | 2025-06-06 |
| 94 | CRANIUM: Post-Market Performance Follow-up Study for The Evaluation of The Presence of Circulating Plasma Brain Biomarkers in Peripheral Blood and Acute Traumatic Brain Injury in Adult Emergency Department Patients PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Each year, approximately 69 million people worldwide suffer from traumatic brain injuries (TBI), representing a significant burden on public health, society, and the economy. Timely and accurate care can influence short-, medium-, and long-term outcomes, making the reduction of diagnostic delays crucial. TBI diagnostics require careful consideration, as initial evaluations may differ from final assessments, and patient conditions may evolve over time. In this monocentric, observational, … |
CHIARA DI RESTA; | 2025-06-24 |
| 95 | Effects of An Acute 1-month Cannabidiol Treatment on Pain and Inflammation After A Long Bone Fracture: A Triple-blind Randomized, Placebo Controlled Clinical Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this project is to investigate the therapeutic potential and safety of acute Cannabidiol (CBD) treatment on longitudinal pain symptoms, and to assess potential interactions with pain mediators including opioids and sex on CBD treatment response. To this end, this research protocol proposes a comprehensive translational approach including a placebo-controlled randomized clinical trial comparing two daily doses of CBD treatment administered for one month on pain relief. This study will also compare intervention conditions on inflammation markers, participant quality of life, sleep quality, depression, anxiety, cognition and orthopaedic function. |
LOUIS DE BEAUMONT; | 2025-07-30 |
| 96 | A Randomised, Double-blind, Placebo-controlled Phase 2a Pilot Study to Evaluate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONP-002 in Adults With Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a Phase IIa, randomized, double-blind, placebo-controlled pilot study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of ONP-002 in adults with mild traumatic brain injury (mTBI). Broadly, a mTBI, often referred to as a concussion, is a type of head trauma that causes temporary disruption to brain function, usually resulting from a blow to the head, fall, or sudden movement, and is often characterised by symptoms of headache, dizziness, confusion, memory problems, and difficulty concentrating, … |
ORAGENICS | 2025-03-11 |
| 97 | A Randomized Controlled Trial Comparing The Effectiveness of Dexmedetomidine Versus Sufentanil on Cerebral Oxygen Saturation in Patients With Traumatic Brain Injury (DESTIN Trial) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This randomized controlled clinical trial aims to evaluate the effectiveness of dexmedetomidine compared with sufentanil on cerebral oxygen saturation in patients with traumatic brain injury (TBI) undergoing surgery under general anesthesia. Cerebral oxygen saturation (rSO₂) will be monitored using Near-Infrared Spectroscopy (NIRS) to assess the impact of both anesthetic regimens on cerebral oxygenation and hemodynamic stability. Patients meeting the inclusion criteria will be randomly assigned into two groups (1:1 ratio) using a simple random draw method. Group A will receive dexmedetomidine 1 µg/kg for induction, thiopental 5 mg/kg, and rocuronium 0.6 mg/kg, … |
MM RUDI PRIHATNO; | 2025-11-28 |
| 98 | Biomarker Role in Assessing Imaging Needs for Mild Cranial Trauma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to determine whether a blood test can help doctors decide when to use a head CT scan for patients with a mild head injury. Researchers are investigating whether the results from this blood test can aid in making better decisions about patient care and potentially reduce the need for imaging. In this study, … |
JONATHAN A. GROSSBERG; | 2025-12-15 |
| 99 | A Randomized Double-blinded Controlled Trial for The Treatment of Persisting Symptoms After Concussion With Psilocybin-assisted Therapy: A Safety and Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this randomized controlled trial is to evaluate the safety, feasibility, and efficacy of psilocybin assisted therapy as an intervention to reduce symptom burden in adult patients (aged 18-65) with persisting symptoms after concussion (PSaC). This trail will test the following 2 aims: AIM 1 : To test the safety and feasibility of an active psilocybin-assisted psychotherapy to an active control for patients with PSaC. AIM 2: To evaluate the efficacy of an active psilocybin-assisted psychotherapy compared to an active control as a treatment for PSaC. Participants will be asked to: * Complete a 2-part screening process * Attend a baseline assessment * Complete a psychoeducation preparation session(s) * Attend psilocybin administration session (receive high dose \[25mg\] or low dose psilocybin \[1mg\]) * Complete 5 weekly sessions of Acceptance and commitment therapy (ACT) * Repeat outcome measures at 1-week, 4 weeks, 3 months, and 6 months post-psilocybin administration (online only at 6 months). |
CHANTEL T DEBERT; | 2025-12-30 |
| 100 | Automated Robotic TCD in Traumatic Brain Injury (ART-TBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study’s objective is to determine the safety, feasibility and efficacy of prolonged automated robotic TCD monitoring in critically ill patients with severe TBI across multiple clinical sites with varying levels of TCD availability and experience |
SHRADDHA MAINALI; | 2025-10-22 |
| 101 | The Effect of Semi-elemental Enteral Nutrition on Gastrointestinal Tolerance in Patients With Traumatic Brain Injury: A Randomized Exploratory Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Study Objective This clinical trial primarily aims to investigate whether semi-elemental enteral nutrition (SEN) improves gastrointestinal tolerance in patients with severe traumatic brain injury (TBI) and to evaluate its impact on clinical outcomes. The safety profile of SEN will also be assessed. Key Research Questions Does SEN reduce the incidence of acute gastrointestinal injury (AGI) in severe TBI patients? Study Design Participants will be randomized 1:1 into either: Intervention group: Receives SEN initiated within 48 hours post-injury and continued for ≥7 days. Control group: Receives standard enteral nutrition over the same period. |
YAN QU; | 2025-07-29 |
| 102 | Crainio Non-invasive Intracranial Pressure Monitor for Traumatic Brain Injury: Product Development PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The clinical investigation aims to advance the Crainio device, designed for non-invasive intracranial pressure (ICP) monitoring. This feasibility study involves 54 participants over a 12-month period and seeks to collect cerebral photoplethysmogram signals alongside concurrent invasive ICP measurements in patients with traumatic brain injury. The primary objective is to establish the diagnostic accuracy of the Crainio device, aiming for at least 90% sensitivity and specificity in detecting raised ICP (above 20 mmHg). Secondary objectives include evaluating patient-related factors such as skin tone, skull thickness, and skull density, … |
CHRIS UFF; | 2026-03-18 |
| 103 | Ubiquitin C-terminal Hydrolase L1 (UCH-L1) and Glial Fibrillary Acidic Protein (GFAP) As Acute Biomarkers for Prediction of Traumatic Brain Injury (TBI) in Children PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to establish if Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) are predictive of computed tomography (CT) findings in pediatric traumatic brain injuries (TBI). The participant population is pediatric patients, ages 0 to less than 18 years old with a possible TBI or trauma-related injury who have blood drawn per standard of care in the emergency department. Blood samples will be analyzed using the i-STAT TBI cartridge (Abbott Laboratories, Abbott Park, IL, … |
GRACE LAI; | 2025-07-30 |
| 104 | Effect of Volatile-based Versus Total Intravenous Anesthesia on Cerebral Homeostasis and Neucognitive Function in Patients Undergoing Elective Craniotomy for Brain Tumor Excision PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The brain is a metabolic active organ with constant energy demands. Brain oxygen supply is secured via cerebral circulation. Brain tumor surgery is commonly associated with the tumor’s underlying pathophysiology including brain swelling or edema. During craniotomy for brain tumor resection maintenance of cerebral hemodynamic stability is of paramount importance. Neuroinflammation is also a normal response to trauma, … |
GEORGIA TSAOUSI; | 2025-10-01 |
| 105 | Reduction of Edema With A Specialized Cocktail for Ultra-early Management in Intracerebral Hemorrhage PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability rates, often worsened by perihematomal edema (PHE), which increases intracranial pressure and leads to poor outcomes. Preclinical studies suggest that a pharmacological cocktail (PPA) may help reduce cerebral edema by modulating potassium balance, preserving aquaporin-4 expression, and enhancing lymphatic drainage. This multicenter, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-05-14 |
| 106 | Lesion-Network Mapping Analysis With Brain Connectomics to Reveal The Neural Mechanisms of Cerebrocardiac Syndrome Following Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebrocardiac syndrome (CCS), including myocardial injury, arrhythmia or heart failure is one of serious complications of traumatic brain injury (TBI), mostly occurs within seven days after TBI, which directly aggravates the brain damage and affects the prognosis of TBI patients. Accumulative evidences suggest that autonomic nervous system disorder is a key initiation point for CCS, but how TBI affects the specific action patterns is not yet clear. Therefore, elucidating the neural mechanisms of TBI-induced CCS, maintaining the central sympathetic-parasympathetic balance through novel interventions such as noninvasive brain stimulation, may fundamentally block the downstream peripheral mechanism, … |
HAO CHEN; | 2025-05-06 |
| 107 | SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospective randomized controlled trial comparing two different physical therapy approaches to the treatment of posttraumatic headache with autonomic symptoms. AIM 1: To establish the efficacy of SPINEPASS against Standard Physical Therapy to reduce headache disability and impact amongst patients with persistent post-concussion headache. AIM 2: Demonstrate the superiority of SPINEPASS in the efficient self-management of headache. Demonstrate its appropriateness, acceptability, and feasibility and gain patient insights among patients with PPTH compared to standard PT. |
LUCY THOMAS; | 2025-03-18 |
| 108 | Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The OVERCOME-TBI project aims to collect multimodal data approximately 1-4 and 11-14 years after an earlier well-documented traumatic brain injury (TBI) and examine factors that influence disease progression in order to gain new scientific insights into the long-term pathophysiology of TBI and identify new therapeutic targets. TBIs are among the most serious health problems worldwide and represents a significant burden for the injured, … |
JUSSI P. POSTI; | 2025-04-15 |
| 109 | Efficacy of Caval Aorta Index for Fluid Optimization in Critically Ill Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic brain injury is a leading cause of death and disability in trauma patients. As the primary injury cannot be reversed; management strategies must focus on preventing secondary injury by avoiding hypotension and hypoxia besides, maintaining appropriate cerebral perfusion pressure, which is a surrogate for cerebral blood flow. |
MAHA ABOU-ZEID; | 2025-04-29 |
| 110 | A Sleep Intervention to Improve Quality of Life and Symptom Management in Veterans With The Polytrauma Clinical Triad PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The polytrauma clinical triad (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain. Veterans with the PCT are medically complex, often refractory to conventional therapies, and suffer from additional related chronic sequela. Notably, sleep disturbances and cognitive impairment, which the investigators hypothesize are significant contributing factors to these functional impairments and an impediment toward rehabilitation. Thus, the investigators’ research aims to intervene at the level of sleep, and by improving sleep, improve these interconnected, disabling, and difficult to treat enduring complexities associated with the PCT – … |
JONATHAN E ELLIOTT; | 2025-06-27 |
| 111 | The Effects of Concussion on Gait and Posture in Individuals With Peripheral Vision Loss Related Papers Related Patents Related Grants Related Experts Highlight: Changes in gait and balance often occur in individuals who have suffered a concussion. In addition, a subset of concussed individuals also experience peripheral vision loss. To date, changes in gait and balance have not been examined in individuals who have suffered a concussion and also experience peripheral vision loss. |
GREGORY ROBERT; | 2025-07-22 |
| 112 | Safety and Efficacy of Thalamic Focused Ultrasound Stimulation (tFUS) for Promoting Recovery After Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this multicenter project aims to (1) establish short-term efficacy of tFUS as a therapeutic to promote recovery in patients with prolonged DoC as compared to sham treatment, (2) establish dose-related safety and efficacy of tFUS as a therapeutic intervention in prolonged DoC patients and (3) explore preliminary predictors and biomarkers of susceptibility and response to thalamic sonication. |
MARTIN M MONTI; | 2025-10-10 |
| 113 | Reduction of Edema With A Specialized Cocktail for Ultra-early Management in Ischemic Stroke PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Large ischemic stroke is a severe subtype of acute ischemic stroke (AIS), often leading to malignant cerebral edema, elevated intracranial pressure, and poor functional outcomes. Despite early aggressive treatment, malignant cerebral edema remains a major determinant of prognosis, even in cases of successful recanalization. Preclinical studies suggest that a pharmacological cocktail (PPA) may alleviate cerebral edema by modulating extracellular potassium balance, maintaining aquaporin-4 expression, and enhancing lymphatic drainage. This multicenter, … |
SECOND AFFILIATED HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY | 2025-04-18 |
| 114 | Evaluation of Patients Suffering From Polytrauma Admitted to The ICU: A Retrospective Cohort Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to assess the number of polytrauma patients admitted to the Intensive Care Unit. In addition, we aim to describe their clinical characteristics, therapeutic management, and clinical outcomes. |
STESSEL BJÖRN; | 2026-03-19 |
| 115 | Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic brain injury (TBI) causes acute deficits in cerebral perfusion which may lead to secondary injury and worse outcomes. Inhaled nitric oxide (iNO) is a vasodilator that increases cerebral blood flow and is clinically used for hypoxic respiratory failure in neonates and adults. The investigators will perform a randomized controlled trial of iNO treatment in TBI patients acutely after injury. The investigators will then assess perfusion changes with optic neuromonitoring, blood biomarkers, and 6 month clinical outcomes. |
SAMUEL SHIN; | 2025-06-03 |
| 116 | Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization’s (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention. |
DAVID DARROW; | 2026-02-23 |
| 117 | Behavioral Treatment of Insomnia in Active-Duty Service Members With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The objective of the study is to conduct a randomized controlled trial of Cognitive Behavioral Therapy for Insomnia (CBT-I) in a sample of active-duty sailors with a history of traumatic brain injury (TBI). The investigators will test the impact of CBT-I on insomnia symptoms as well as post-concussive symptoms, psychological symptoms, and neurocognitive functioning in comparison to treatment as usual. The investigators will also compare the effectiveness of traditional in-person CBT-I and CBT-I delivered via a clinician-supervised digital health platform, Clinician Operated Assistive Sleep Technology (COAST) in comparison to treatment as usual on symptoms of insomnia, post-concussive symptoms, neurocognitive functioning, … |
ANNE GERMAIN; | 2025-04-24 |
| 118 | HIT HEADS 2.0: Head Injury Treatment: A Randomized, Placebo-controlled, Double-blinded, Therapeutic Clinical Trial of Branched Chain Amino Acids (BCAAs) in The Treatment of Concussion PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion. The aim of the study is to determine whether administration of high-dose BCAAs compared to placebo promotes concussion recovery. |
AKIVA COHEN; | 2025-06-13 |
| 119 | Early Neuromodulation for Cognitive Recovery and Rehabilitation in Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The two goals of the proposed study are: (1) To determine how brain activity changes with cognitive recovery over time from acute to chronic phases of traumatic brain injury (TBI). (2) To determine how the time of anodal transcranial electrical stimulation (A-tES) administration affects cognitive performance and brain activity in TBI. To achieve these study goals, the investigators will conduct a pilot clinical trial over three years in which the investigators aim to recruit 60 patients with moderate to severe TBI at the University of Cincinnati Medical Center (UCMC). During the acute phase of TBI, … |
ISHITA BASU; | 2025-03-25 |
| 120 | Effects of Neurobiological Therapy With Asymmetric Radio-electric Conveyer (REAC) in Diffuse Axonal Injury: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Background: Severe traumatic brain injury, particularly diffuse axonal injury (DAI), often leads to lasting neurological issues. Cerebral dysfunction in DAI can be evaluated by monitoring cerebral electrical activity (CEA) through EEG. The radio electric asymmetric conveyer (REAC) is a noninvasive method designed to rebalance cellular polarity via endogenous bioelectric fields and modulate CEA. This technique may alter CEA, which can be detected using quantitative EEG (qEEG). Objective: To assess qEEG changes following DAI and brain wave alterations after a REAC protocol in this group. Methods: In this prospective, randomized, double-blind clinical trial, … |
SERGIO BRASIL; | 2026-01-28 |
| 121 | Evaluating A Novel Method to Determine The RTMS Dose Needed for Treating Depression After Spinal Cord Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Depression is a leading cause of disability worldwide and is more commonly seen in individual’s post-spinal cord injury (SCI) than in the general population. Depression post-SCI impacts an individuals’ quality of life and recovery. It has been reported that among Veterans with an SCI, those without depression live longer than those with depression. Thus, depression must be treated appropriately. Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression, but dosing is based on a motor response or movement in the thumb. Over half of individuals with SCI have some degree of arm or hand impairment, … |
CATHERINE J VANDERWERKER; | 2026-01-14 |
| 122 | The Value of Combined Detection of Different Blood Biomarkers in The Diagnosis and Treatments of Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: TBI, as a potential risk factor, causes a 1.5 times higher risk of neurodegenerative disease to up to 30-70% of TBI patients with neurological symptoms. Brain trauma is an important global medical, public health and social problem. Early diagnosis and effective treatment can effectively reduce the disability rate of patients and the incidence of neurological sequelae, and has increasingly become the focus of the international scientific research community. Exploring blood-based biomarkers has potential clinical value, which can greatly help clinicians to evaluate patients’ conditions and develop reasonable plans, … |
FIRST AFFILIATED HOSPITAL XI’AN JIAOTONG UNIVERSITY | 2025-03-03 |
| 123 | Effects of Cerebrolysin on Language Ability in Non-fluent Aphasia Patients After Stroke: A Randomized, Placebo-controlled, Double-blinded, Single Center Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to measure changes in language ability after adding cerebrolysin to standard treatment for non-fluent aphasia patients with post-stroke language impairment. The patients are divided into two groups: the experimental group, which receives a combination of standard treatment (speech therapy) and cerebrolysin, and the control group, which only receives standard treatment (speech therapy). By comparing the PK-WAB scores before and after drug administration, the study seeks to analyze the impact of cerebrolysin on language improvement. According to various stroke registries, … |
YONSEI UNIVERSITY | 2025-03-26 |
| 124 | The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter The Gut Microbiome and Neurologic Symptoms PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the microbiome leading to changes in fatigue and cognition. |
RANDALL URBAN; | 2025-12-19 |
| 125 | Implementation of An Evidence-Based Educational Resource for Children With Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this prospective, observational study is to (1) collaborate with our stakeholders to identify essential mTBI-information from existing evidence-based materials to develop a Post-mTBI Educational Resource for children with mTBI and their parents and (2) implement our Post-mTBI Educational Resource into clinical practice to determine feasibility, acceptability, and appropriateness at Baylor Scott and White (BSW) clinical sites that treat children with mTBI. |
BAYLOR RESEARCH INSTITUTE | 2026-02-17 |
| 126 | A Confirmatory Study of The Simplified Chinese Version of The Loewenston Occupational Therapy Cognitive Assessment (LOTCA) Battery (2nd Edition) to Assess Cognitive Impairment in Patients with Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: In this study, 300 patients aged ≥18 years old with traumatic brain injury (case group) and hospitalized patients without central nervous system disease or their family members and accompanying staff (control group) were selected as the study objects. At baseline, participants completed the Mini-mental State Examination (MMSE), the Loewenston Occupational Therapy Cognitive Assessment (LOTCA) battery, the Glasgow Coma Scale (GCS), and the Alzheimer’s Disease Rating Scale Cognitive Subscale (ADAS-Cog11). The evaluation process of the first LOTCA test was videotaped by a person. 2 weeks after the evaluation, … |
TONG RU YU; | 2025-02-27 |
| 127 | Effects of An AI-driven Personalized Exercise Feedback Program on Exercise Adherence and Health Outcomes in Patients with Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to develop and evaluate an AI-driven Personalized Exercise Feedback Program (AI-PEF) to enhance exercise adherence and health outcomes in mTBI patients. Methods: AI-PEF integrates the transtheoretical model and self-determination theory with machine learning algorithms to provide real-time, personalized feedback. A phased randomized controlled trial will be conducted: Phase I evaluates feasibility and acceptability through Delphi methods with expert consensus and patient feedback; Phase II validates preliminary outcomes with 30 participants in a 2-arm randomized trial; and Phase III assesses the program’s impact on adherence, sleep quality, depressive symptoms, … |
HUI-HSUN CHIANG; | 2025-02-12 |
| 128 | Can A High Intensity Exercise Program for People With Neurologic Disabilities Run By Doctoral of Physical Therapy Students Improve Mobility in Everyday Life PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The Hawks in Motion (HIM) High Intensity Exercise program is designed to implement the American Physical Therapy Clinical Practice Guidelines and American College of Sports Medicine recommendations for exercise for people with neurologic disability. Doctor of Physical Therapy (DPT) students administer the HIM High Intensity Exercise Program. A prior study evaluated the feasibility, safety, and efficacy of the HIM High Intensity Exercise Program and found it feasible, safe, … |
MARY GANNOTTI; | 2025-11-03 |
| 129 | An Assessment of Clinical Efficacy of Hypothermic Therapy Following Mild Traumatic Brain Injury (mTBI) in The Adolescent Athlete As Compared to An Untreated Active Control Population PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study is being conducted to quantify the clinical safety and efficacy of head and neck cooling, using the Pro-2-Cool device, when applied after mTBI injury sustained by adolescents aged 12-21 years, participating in sporting activities. |
BRIAN REILLY; | 2025-07-25 |
| 130 | Hypertonic Lactate After Cardiac Arrest PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The study is intended to test the hypothesis that sodium lactate infusion after resuscitation from a cardiac arrest will decrease the magnitude of brain damage, as measured by the serum biomarker concentration of NSE. |
FILIPPO ANNONI; | 2025-02-21 |
| 131 | Delivering Transcutaneous Auricular Neurostimulation (tAN) to ICU Patients With Traumatic Brain Injury (tAN-TBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The overarching goal of this pilot study is to assess the feasibility and safety of transcutaneous auricular neurostimulation (tan) in ICU patients with TBi and to determine the effect of tan on serum markers of inflammation. exploratory analyses will examine effects on such physiological parameters as blood pressure, heart rate, and intracranial pressure (iCP), as well as measures of neurological function. |
ALEX VALADKA; | 2026-02-18 |
| 132 | Feasibility, Safety, and Preliminary Efficacy of Median Nerve Stimulation for Cognitive Dysfunction in Patients With Acute Traumatic Brain Injury (MARS-TBI): Study Protocol for A Pilot Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Currently, the treatment of cognitive dysfunction after acute TBI remains a challenge, and novel therapeutic methods are urgently needed. Median nerve stimulation (MNS) is a non-invasive neuromodulation technique and recently has shown positive effects in awaking coma of acute brain injury. It has been shown to improve cognition in healthy volunteers and may be a potential therapeutic approach for cognitive dysfunction in patients with acute TBI. Therefore, the main purpose of the study is to evaluate the feasibility, safety, and preliminary efficacy of MNS for cognitive dysfunction in patients with acute TBI. |
GUOYI GAO; | 2026-02-17 |
| 133 | Evaluation of The Abbott I-STAT TBI Biomarker Test for Effect on Decreasing CT Utilization Among Adult Emergency Department Patients With Suspected Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: According to the Centers for Disease Control and Prevention, approximately 200,000 hospitalizations occurred in 2020 related to Traumatic Brain Injury (TBI), which does not include many TBIs treated only in emergency departments, urgent care, primary care, or that are not evaluated by a clinician. Head CT is a critical component of care for severe TBI, however in mild TBI there is practice variation with a wider risk to benefit estimation for obtaining head CT imaging. Potential disadvantages of head CT include longer Emergency Department (ED) length of stay (LOS), higher costs, … |
SHAMEEKE TAYLOR; | 2025-02-20 |
| 134 | Capturing Autobiographical Memory Formation in People Moving Through Real-World Spaces Using Synchronized Wearables and Intracranial Recordings of EEG PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main questions it aims to answer are: How does the brain encode and retrieve real-world autobiographical memories? Can multimodal data integration enhance our understanding of memory-related cognitive and neural mechanisms? Participants will: * Use a smartphone-based recording application (CAPTURE app) to collect real-world data. * Have their wearable sensor data (e.g., audio-visual, accelerometry, GPS, autonomic physiology, … |
CORY INMAN; | 2025-04-08 |
| 135 | Pilot Study on The Correlation Between Accelerations Experienced During Matches By Professional Rugby Players and A Profile of Salivary Biomarkers Identified in The Literature As Related to Concussion PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Concussion, or mild traumatic brain injury, accounts for 85% of brain injuries and is common in both professional and amateur sports. It results from kinetic impacts causing a temporary disruption of brain function, often without visible abnormalities on imaging, making diagnosis difficult. The majority of concussions remain undetected, without specific management. To facilitate detection, the development of reliable salivary BMs is essential, as they offer a non-invasive, rapid, and simple method for early identification of biological changes related to concussions. |
MALIK KAHLI; | 2026-04-02 |
| 136 | Evaluating The Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Propranolol primarily acts as a non-selective beta blocker, blocking both beta-1 and beta-2 adrenergic receptors, while carvedilol exhibits a broader spectrum of action by also blocking alpha-1 adrenergic receptors. The receptor blockade profile of a beta blocker can influence its physiological effects and potential therapeutic benefits in TBI. Therefore, the variation in receptor selectivity may result in differences in their impact on secondary brain injury processes and patient outcomes. |
NOHA MANSOUR; | 2025-04-02 |
| 137 | SAFETY: Stabilization Points to Third Hospital Line Assessment OF The Impact of The UsE of Infrascanner Model 2500 to Provide Decision Support for Diagnosis/Screening of Traumatic Brain InjurY in Ukraine PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The Infrascanner model 2500 is a handheld, noninvasive device that is FDA-cleared to detect traumatic intracranial hematomas. FDA clearance K200203 was issued in 2020, K211617 added pediatric age group to the IFU in 2022, … |
BARUH BEN DOR; | 2025-06-11 |
| 138 | Clinical and Epidemiological Evaluation of Patients Affected By Traumatic and Hypoxic-ischemic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: According to the World Health Organization, perinatal asphyxia is the leading cause of severe neurological disabilities and the second leading cause of neonatal death among term infants, with an incidence of 3.94-5.12 per 1,000 live births. Perinatal asphyxia leads to neonatal hypoxic-ischemic encephalopathy, which remains a common cause of neonatal death and long-term disabilities, affecting 1.5-3 per 1,000 live births in developed countries and up to 26 per 1,000 live births in developing countries. This condition is characterized by altered levels of consciousness or manifests with seizures, often associated with difficulties in initiating and maintaining breathing, … |
ANTONIO CHIARETTI; | 2025-03-12 |
| 139 | Stimulating After Recovery From Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and decision-making. |
DAVID DARROW; | 2025-03-17 |
| 140 | CSP #2018 – Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild traumatic brain injury (mTBI). |
VA OFFICE OF RESEARCH AND DEVELOPMENT | 2025-12-17 |
| 141 | Prospective Ocular Imaging for Intracranial Pressure Evaluation PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a prospectively recruiting, database development study collecting images and videos of the spontaneous venous pulsation at the back of people’s eyes – this is a pulse one can see on examination of the back of the eye, originating from the blood vessels around the nerve that connects the eye to the brain (the optic nerve), and is present in most people who have normal pressure around the brain. However, in people with raised pressure in the brain, this pulse disappears as the pressure rises. Many things can cause the pressure around the brain to increase, including tumours, … |
KING’S COLLEGE HOSPITAL NHS TRUST | 2025-03-03 |
| 142 | Safety and Efficacy of Botulinum Toxin A in Patients With Posttraumatic Headache: A Double-blind, Randomized, Placebo-controlled, Parallel-group Trial and Investigation of Neuroinflammatory Biomarkers As Predictors of Efficacy PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study is an investigator-initiated randomized, placebo-controlled, double-blind, parallelgroup trial. Eighty subjects with PTH will be included and randomized 1:1 for treatment with BTX-A or placebo (isotonic saline). The study comprises a 4-week baseline phase before injection of either active drug or placebo followed by a 12-week evaluation period. Treatment will be double-blind, and subjects will only receive one treatment cycle. Endpoints will be assessed in the evaluation period (weeks 5 to 8) compared to baseline (weeks -4 to -1). |
HENRIK SCHYTZ; | 2025-02-21 |
| 143 | PECARN Versus NICE Guidelines for Pediatric Head Trauma in Emergency Department in Assuit and Sohag University Hospitals PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: the safety and validity of the PECARN with 100% sensitivity in both age groups in identifying patients with ciTBI and theoretically in reducing performed CT scans by 29%. Therefore, in patients classified in the low-risk category, … |
NOHA BADRAN ABDELMAWGOUD; | 2026-03-01 |
| 144 | Repetitive Transcranial Magnetic Stimulation Paired with Augmented Reality to Alter Concussion Symptoms PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aims to determine whether the delivery of brain stimulation paired with a balance training task can improve symptoms of dizziness for individuals experiencing these symptoms due to concussion. The main questions it aims to answer are: – Does repetitive transcranial magnetic stimulation (rTMS) paired with balance training improve the symptoms of dizziness in individuals with persistent dizziness due to concussion? – … |
AIMEE NELSON; | 2025-12-01 |
| 145 | Can Somatic Tracking Help People Living with Tinnitus? PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: We are examining the effect of mindfulness meditation on attitudes towards tinnitus, as well as physical and psychological distress associated with the condition. The meditation is designed to promote neuroplasticity, fostering new neural connections to help you reinterpret tinnitus through a lens of safety and reduce the perception of threat. This approach integrates several techniques from various psychological therapies which have been promising in reducing tinnitusrelated distress. Therefore, the purpose of this study is to see whether a guided mindfulness meditation intervention is effective in improving the acceptance of tinnitus symptoms, … |
FLORIAN VOGT; | 2025-03-26 |
| 146 | Non-invasive Continuous Hemodynamic Monitoring in Acute Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this observational study is to explore the relationship of heart function with the course and outcomes after traumatic brain injuries and nontraumatic intracerebral hemorrhage. The goal is to explore association between routinely collected hemodynamic and brain monitoring data. Participants already taking intervention A as part of their regular medical care and the investigators will follow up with participants 6 months after discharging the hospital. |
CHRISTOS LAZARIDIS; | 2026-03-04 |
| 147 | Testing The Efficacy of A Memory Training Program to Improve New Learning and Memory in Portuguese Patients With Multiple Sclerosis: A Randomized Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Deficits in memory and learning are common in Multiple Sclerosis, posing significant challenges in patients’ daily lives. Cognitive rehabilitation has been shown to be effective in ameliorating these deficits, with programs such as the Modified Story Memory Technique (mSMT). In Portugal, no studies tested the efficacy of memory training programs. We aim to fill that gap by translating and developing mSMT, conducting a randomized double-blind, placebo-control, clinical trial, and, therefore, testing its efficacy through objective measures of cognitive function, … |
MÁRCIA INÊS TEIXEIRA FRANÇA; | 2025-02-12 |
| 148 | 3D Transcranial Ultrasound Brain Imaging (3D-TRUBI) Instrument for Point-of-Care Diagnosis of Intracranial Hemorrhages Caused By Traumatic Brain Injuries PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The primary objective of this study is to assess the safety of the 3D Transcranial Ultrasound Brain Imaging (3D TRUBI) device in Traumatic Brain Injury (TBI) patients with intracranial hemorrhage (ICH). The secondary objective is to assess the diagnostic potential of 3D TRUBI. The latter will be achieved by comparison of 3D TRUBI scans with admission head computed tomography (CT), … |
THE GENEVA FOUNDATION | 2025-03-20 |
| 149 | Cognitive Behavioral Therapy for Insomnia Vs Brief Behavioral Therapy for Insomnia in Military Personnel With Postconcussive Symptoms Following Mild Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: This is a single site, two-armed random controlled trials (RCT) comparing six sessions of Cognitive Behavioral Therapy for Insomnia (CBT-I) with four sessions of Brief Behavioral Therapy for Insomnia (BBT-I) in service members with comorbid insomnia and prolonged postconcussive symptoms present for at least 3 months after Mild Traumatic Brain Injury (mTBI). |
KRISTI PRUIKSMA; | 2026-01-07 |
| 150 | Using High Definition Transcranial Direct Current Stimulation to Treat Verbal Retrieval Deficits Secondary to Chronic Traumatic Brain Injury (HDtDCS-CTBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will improve verbal retrieval in civilian (non-military, non-veteran) participants with histories of traumatic brain injuries. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition, concussion history, structural brain imaging, and EEG predict responses to treatment over time, … |
JOHN HART; | 2025-11-24 |
| 151 | Diagnosis Value of Interoceptive EEG Indicators By Rectal Stimulation in Patients With Disorders of Consciousness PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Study on the Significance and Value of Interoception-Related Indicators in the Classification of Patients with Disorders of Consciousness (DoC) via Rectal Stimulation |
YILIN ZHAO; | 2025-10-06 |
| 152 | Rock Steady: A Mobile, Gamified Vestibular Rehabilitation Therapy App for Adults With Dizziness Related to Mild Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to compare outcomes for standard vestibular rehabilitation home program to a digital vestibular rehabilitation home program in adults with dizziness related to mild traumatic brain injury (mTBI). The main question is whether participants who use the digital format of vestibular rehabilitation improve to a greater extent at discharge than those who use the standard format. Participants will undergo a customized vestibular rehabilitation home exercise program per standard of care, consisting of gaze stabilization, habituation, balance and gait exercises, … |
KAREN SKOP; | 2025-12-17 |
| 153 | Analysis of Motor Performance Improvement Following Visual Rehabilitation Treatment in Individuals with Visual Field Defects Due to Acquired Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Acquired brain injury refers to brain damage that impacts neurological processing, making daily activities challenging and often causing vision issues like binocular dysfunction, oculomotor problems, and visual field loss. In Spain, visual rehabilitation is limited, although it is more common in other countries. These patients generally need an interdisciplinary approach involving professionals like physiotherapists and optometrists and often face mobility, balance, and spatial perception difficulties. Treatment tools include lenses, prisms, and technologies like virtual reality (VR). The Visionary VR program, presented by Dr. Portela, … |
CARMEN LOPEZ; | 2025-12-31 |
| 154 | Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics (CUPID-Peds) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: To improve patient selection for head CT, a safe and high sensitivity screening neuroimaging modality is needed. Currently many clinicians must make treatment decisions based solely on the patients clinical exam, which has low sensitivity and specificity and low inter-rater reliability. This study is being done to learn more about B-mode cranial point-of-care ultrasound (cPOCUS). Ultrasound has several advantages. It is a safe, non- invasive, low-cost, fast and portable bedside tool without ionizing radiation exposure. |
DENISE FRAGA; | 2025-08-28 |
| 155 | The Application of Ultrasonic Measurement of Optic Nerve Sheath Diameter in Liposuction Surgery PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main purpose of this study is to investigate the effect of changes in Optic Nerve Sheath Diameter (ONSD) measured at different operating position during Liposuction Surgery. Optic nerve sheath diameter (ONSD) has been shown to be a noninvasive indicator for monitoring intracranial pressure changes. The use of anesthetic drugs will reduce the intracranial pressure. However, prone position and large fluid infusion can still lead to increased intracranial pressure. The investigators hypothesized that during sedation and analgesia anesthesia, patients in prone position had higher ONSD. |
XU WENLI; | 2025-09-30 |
| 156 | The Effect of Mirror Therapy on Upper Extremity Motor Function in Stroke Rehabilitation PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study aimed to determine the effect of mirror therapy versus conventional physical therapy treatment in improving upper extremity impairments and motor function among chronic hemiplegic subjects. Research Objectives: 1. To discover the effectiveness of conventional physical therapy treatment on improving upper limb motor function among chronic hemiplegic subjects. 2. To find out the effect of mirror therapy along with conventional physical therapy treatment on improving upper limb motor function among chronic hemiplegic subjects. 3. To find out the effectiveness of mirror therapy combined with conventional physical therapy treatment versus conventional physical therapy treatment alone on improving upper extremity motor function among chronic hemiplegic subjects. |
KARTHICK BALASUBRAMANIAN; | 2025-07-30 |
| 157 | Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this clinical research project is to employ Mespere LifeSciences NeurOs Cerebral Oximetry system, equipped with noninvasive sensors approved by the FDA, to monitor and investigate the correlation within a cohort of patients suffering from traumatic brain injury (TBI), stroke, brain tumor, and brain bleeding. This study aims to investigate and establish the correlation between blood vessel functionality parameters-specifically, Vasodilation/Constriction Index (VDC), Vascular Resistance Index (VR), and Volume Reactivity Index (VRx)-with the crucial physiological indicators, Intracranial Pressure (ICP) and Mean Arterial Pressure (MAP). By doing so, … |
JIAPENG HUANG; | 2025-05-30 |
| 158 | Investigation of The Effects of Tele-rehabilitation-based Motor Imagery Training on Kyphotic Angle, Pain, Depression, and Quality of Life in Individuals With Posture Disorders PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Objective: Kyphosis is one of the most common postural problems. It is defined as a thoracic curvature that exceeds normal limits. The Cobb angle, also known as the kyphosis index, can be used to determine the degree of this curvature. Motor imagery (MI) is defined as visualising movement in the mind without actually moving. Studies have shown that similar brain regions are activated during motor imagery and actual movement. regions are activated during motor imagery and actual movement. Most of the information about motor imagery training has been obtained from studies of stroke patients, … |
EMRAH ZIREK; | 2026-03-13 |
| 159 | Prismatic Adaptation for Cognitive Rehabiliation in Traumatic Brain Injury Patients PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The study aims to evaluate the effects of prismatic adaptation and then of a novel rehabilitation protocol that combines PA and Serious Games on cognitive and behavioural deficits in patients with traumatic brain injury , compared to a rehabilitation training without prismatic adaptation. Moreover, … |
SIMONA SPACCAVENTO; | 2026-03-25 |
| 160 | Incidence, Characteristics and Evolution of Cerebral Vasospasm with Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated By Subarachnoid Hemorrhage At Martinique University Hospital PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for 30% of deaths by trauma. It is complicated in 30-60% of cases by subarachnoid hemorrhage (SAH), which makes it the leading cause of SAH. SAH and its complications are well described when the origin is aneurysmal, … |
MARIE SABIA; | 2025-03-31 |
| 161 | Fluid Dynamics of Concussion in Mixed Martial Arts in A Pilot Randomized Controlled Trial of Osteopathic Manipulative Medicine PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose is to test how osteopathic medicine (OMM) improves recovery after a hit to the head during Mixed Martials Arts (MMA). The small changes in the bone, joints, … |
JAYME MANCINI; | 2025-02-28 |
| 162 | Deep Brain Stimulation (DBS) for The Treatment of Cognitive Deficits After Traumatic Brain Injury (TBI): Pilot Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Patients with memory and cognitive deficits following TBI that do not respond to conventional treatments experience a decrease in quality of life. Despite advances in neuroimaging, genetics, pharmacology and psychosocial interventions in the last half century, little progress has been made in altering the natural history of the condition or its outcome. This study would explore whether a surgical therapy is safe and potentially effective in patients who develop refractory memory and cognitive deficits following TBI. Preclinical studies suggest that DBS may improve memory deficits in TBI models. Moreover, … |
NIR LIPSMAN; | 2025-02-11 |
| 163 | A Randomized Controlled Trial Investigating The Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy Related Papers Related Patents Related Grants Related Experts Highlight: This prospective double blind phase II study seeks to evaluate the safety and efficacy of BRC-003, a high CBD investigational product, in the treatment of refractory PTE (Post-Traumatic Epilepsy). The research is divided into two phases: an open-label dose-finding phase (Part A) and a subsequent randomized controlled phase (Part B). This design aims to provide a thorough understanding of the investigational product’s impact on seizure frequency, seizure severity, mood, anxiety, sleep, and quality of life. |
PAUL LYONS; | 2025-04-24 |
| 164 | Pilot Testing of Metacognitive Strategy Training to Address Cancer-related Cognitive Impairment in Breast Cancer PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this proposed project is to evaluate the feasibility and preliminary effect of metacognitive strategy training to improve activity performance, cognition, and quality of life in breast cancer survivors with cancer-related cognitive impairment (CRCI). The other goal of this proposed project is to examine the effects of CO-OP on resting (rsFC)- and task-state functional connectivity as compared to an inactive control group. |
ANNA BOONE; | 2026-02-19 |
| 165 | Multicentric Study on Implementation of Virtual Reality for Rehabilitation of Cognitive Functions in Patients With Severe Acquired Brain Injury: A Randomized Controlled Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Considerable evidence exists for using Virtual Reality (VR) for rehabilitation of acquired brain injury (ABI), with a particular focus on stroke. However, to date very little evidence has been collected in patients with ABI with different aetiologies (i.e., traumatic or anoxic brain injury) and level of severity (i.e., severe, sABI). The present multicentre study aims to overcome current literature issues as heterogeneity of populations and outcomes, small sample sizes and a lack of randomized controlled trials, which can affect the level of evidence and generalizability of results, … |
ANNA ESTRANEO; | 2025-09-29 |
| 166 | To Drill or Not to Drill: Do Memory Drills Help Strengthen Prospective Memory and Decrease Veterans’ Concerns About Prospective Memory Problems? PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to memory drilling works in improving the ability to remember to do something later in treatment-seeking veterans. The main question it aims to answer is: Does adding memory drilling to intensive treatment programs improve the patient’s ability to remember to do something later? Researchers will compare typical standardized memory training to the memory training with drilling to see if drilling improves the veterans’ ability to remember tasks they are supposed to do later. Participants will: * complete the Operation Mend intensive treatment program with either standard care (either with or without Post-Traumatic Stress Disorder \[PTSD\] focused trauma therapy) or standard care + memory drilling * complete a virtual memory assessment at entrance, exit, and three months post exit. This assessment will include questionnaires, interviews, and computerized and naturalistic memory tasks. |
DELANY THRASHER; | 2025-12-19 |
| 167 | Transcranial Doppler Versus Computed Tomography In Evaluation Of Brain Edema In Patients With Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to assess the role of transcranial Doppler (TCD) in evaluating brain edema in traumatic brain injury. The main question it aims to answer is: Is TCD equivalent to brain computerized tomography (CT) in evaluating traumatic brain edema? Participants will be examined by both methods at the same time to assess the correlation between them. |
ALEXANDRIA UNIVERSITY | 2025-08-12 |
| 168 | Efficacy and Safety of Black Seed Oil As Adjunctive Therapy in Pediatrics With Attention-Deficit/Hyperactivity Disorder PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Attention-Deficit/Hyperactivity Disorder is one of the most prevalent neuropsychiatric disorders affecting children with known persistence into adulthood in about 60% of patients. The mainstay treatment for ADHD is the pharmacological treatment involving stimulants (methylphenidate, amphetamines) and non-stimulants (atomoxetine, guanfacine, clonidine). Although these options have been found to be effective, these agents may not always be promising, as a proportion of patients may not respond or may not be able to tolerate their adverse events. Thus, increasing studies are exploring alternative therapies for ADHD, … |
MANAR HOSNEY; | 2025-10-01 |
| 169 | Wearable Device-Based Analysis of The Relationship Between Sleep Patterns and Clinical Prognosis in Patients With Mild to Moderate Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: In patients with traumatic brain injury, post-traumatic sleep patterns have the potential to impact clinical prognosis. While some progress has been made in the study of sleep and prognosis in patients with traumatic brain injury, there is still lack of research on the relationship between sleep and clinical prognosis in post-traumatic patients due to differences in study design, patient age, severity of trauma, and definitions of sleep disorders. Additionally, the primary data collection methods employed in most studies have been self-reported sleep assessments, which are subject to potential biases and inaccuracies. Therefore, … |
GENERAL HOSPITAL OF NINGXIA MEDICAL UNIVERSITY | 2025-10-30 |
| 170 | Uncovering The Acute Neurobiological Significance of Emerging Sexual Behaviors PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to examine the acute effect of being choked during partnered sex on neurological measures. The study is designed to identify the effects being choked during partnered sex on the brain through the use of neural-injury blood biomarkers, functional, diffusion, and perfusion MRI, and ocular-motor function across 3 time points (baseline, post-choking, post-non-choking). The central hypothesis is that acute neuronal structural, physiological, and functional alterations will be amplified after an incidence of choking-involved sex. The neural-injury blood biomarkers neurofilament light (NfL), glial fibrillary acidic protein (GFAP), Ubiquitin C-Terminal Hydrolase L1 (UCH-L1), … |
KEISUKE KAWATA; | 2025-04-01 |
| 171 | Ketamine for Sedation in Severe Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This protocol is for an open-label randomized trial evaluating the safety of using ketamine in combination with propofol for sedation versus the standard of care analgosedation in patients admitted to the intensive care unit with severe traumatic brain injury. |
BRADLEY DENGLER; | 2025-07-14 |
| 172 | Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this blinded, adaptive, randomized, placebo-controlled clinical trial is to investigate the use of hyperbaric oxygen as a therapy to treat mild to moderate traumatic brain injury in Veterans and active military. The main questions it aims to answer are: * Does Hyperbaric Oxygen Therapy (HBOT) reduce neurobehavioral symptoms? (Aim 1) * How many HBOT sessions are needed to achieve a significant reduction in neurobehavioral symptoms? (Aim 2) * Does HBOT reduce posttraumatic stress disorder (PTSD) symptoms? (Aim 3) Exploratory objectives will explore if there are changes in: 1.) cognitive functioning using neuropsychological tests and the National Institutes of Health (NIH) toolbox, 2.) inflammation biomarkers in blood, 3.) microbiome in stool samples, 4.) electroencephalogram (EEG), 5.) sleep characteristics, and 6.) fMRI. Research will compare HBOT therapy to a placebo condition to see if HBOT works to treat neurobehavioral symptoms. The placebo condition is a chamber that remains unpressurized and has 21% oxygen. Participants will: 1. Complete baseline assessments to determine eligibility. 2. Attend 40 sessions of HBOT or placebo (normal air) within 12 weeks. 3. Complete questionnaires and interviews throughout the course of the study. 4. Complete a 2-week post treatment visit |
HARRY VAN LOVEREN; | 2025-11-19 |
| 173 | CONSTRAINT-INDUCED MOVEMENT THERAPY (CIMT) VS. MIRROR THERAPY (MT) ON HAND FUNCTION AND SPASTICITY IN PATIENTS WITH HEMIPARESIS PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study aimed to compare the effects of Constraint-Induced Movement Therapy (CIMT) and Mirror Therapy (MT) on hand function and spasticity in individuals with hemiparesis. A total of 68 participants diagnosed with hemiparesis due to stroke or traumatic brain injury were recruited and randomly assigned to two equal groups. Group A received CIMT, … |
MAHNOOR ALEEM; | 2025-04-04 |
| 174 | Targeted Auditory Plasticity Training to Improve Central Hearing in Mild Traumatic Brain Injury (mTBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators are working on a project to help people who have had mild brain injuries hear better. Sometimes, these injuries can make it hard for people to hear clearly, especially in noisy places or when trying to tell where sounds are coming from. The project is testing special training exercises that have helped healthy people improve their hearing in these situations. The goal is to see if these exercises can also help people with mild traumatic brain injuries (mTBI). If these exercises work, … |
ROCIO NORMAN; | 2025-11-21 |
| 175 | Improving In-hospital and Post-discharge Patient Education for Mild Traumatic Brain Injury PF:7 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to develop and validate ways to provide better patient education and clinical management for individuals who go to the emergency department (ED) with concussion or mild traumatic brain injury (mTBI). |
LINDSAY NELSON; | 2025-07-15 |
| 176 | Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury (CEPU-AKI) in Hemorrhagic Shock Patients: A Prospective Randomized Controlled Trial PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The investigators propose a single-center, randomized, controlled trial to determine whether early initiation of proton pump inhibitor (PPI), pantoprazole, will decrease acute kidney injury (AKI) for trauma patients presenting with hemorrhagic shock compared to routine timing of initiation of PPI. Kidney injury will be assessed by the urinary kidney injury biomarkers, and the incidence, … |
YAFEN LIANG; | 2026-02-19 |
| 177 | The Effects of Exoskeletal Robot-Assisted Gait Training on Children With Cerebral Palsy: An Open-label, Pre-Post Comparison Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Cerebral Palsy (CP) is a complex neurodevelopmental disorder caused by early brain injury, leading to motor impairments such as muscle weakness, stiffness, and gait instability, which impact daily functioning. Gait training is crucial for improving mobility and independence in children with CP. Recently, robotic gait training (RAGT) devices, such as exoskeletons, have been explored as a rehabilitation tool. Although widely studied in adults, evidence of the effectiveness of RAGT in children with CP is limited. Preliminary studies have shown promising results in improving motor function and gait in children, … |
KYUHOON LEE; | 2025-06-12 |
| 178 | Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury Related Papers Related Patents Related Grants Related Experts Highlight: Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with task-specific training. Using a double blind cross-over study we will test whether AIH and task-specific airway protection training improves airway protection more than training alone in individuals with chronic mild-moderate traumatic brain injury (TBI). |
ALICIA Z VOSE; | 2026-01-09 |
| 179 | Effects of Prolonged and Chronic Critical Illness Induced By Brain Injury on Metabolic State: Matched Case-control Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Brain injuries, including acute stroke (AS) and traumatic brain injury (TBI), are prevalent pathologies with severe consequences. Cerebral infarction accounts for 65-85% of AS cases, while hemorrhagic stroke, though less common, has a higher mortality rate (30-50%) and limited recovery (10-20%). TBI is a significant medical and socioeconomic issue due to its high prevalence, severe consequences, and the high rates of temporary and permanent disability, particularly among young and working-age adults. The average mortality rate for severe TBI is 39%, with 60% facing unfavorable outcomes according to the Glasgow Outcome Scale. High levels of permanent disability, … |
ALEXANDER SHESTOPALOV; | 2024-10-15 |
| 180 | Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for The Acute Treatment of Traumatic Brain Injury PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to determine if experimental drug treatment improves recovery after TBI as compared to a control (placebo) group. Changes in recovery will be measured throughout the study. The study drugs listed below are approved by the U.S. Food and Drug Administration (FDA) but are being used off-label in this study. This means that the drugs are not currently approved to treat TBI. |
GEOFFREY MANLEY; | 2025-12-22 |
| 181 | Efficacy of Carotenoids on Blood Biomarkers Following A Collision Sport Athletes PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This is a supplement study being conducted to find out if collision sport athletes who are exposed to repetitive head impacts while supplementing with carotenoids will have decreased pro-inflammatory blood biomarkers, increases in macular pigment optical density, improved contrast sensitivity, greater retinal nerve fiber thickness, and better overall visual quality of life scores compared to collision athletes taking a placebo. |
SEMYON M. SLOBOUNOV; | 2025-03-11 |
| 182 | Therapeutic Normothermia in The Treatment of Traumatic Brain Injury Trial: Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This feasibility trial is the first step in testing the hypothesis that maintenance of normal body temperature, called therapeutic normothermia (TN), for 72 continuous hours in traumatic brain injury (TBI) patients can improve cognitive function. The trial aims to answer the following questions: 1. Is it feasible to conduct this study? Conducting the trial includes the ability to identify and enroll appropriate participants, implement TN, … |
IAN BALL; | 2025-12-01 |
| 183 | Remotely Supervised TDCS Combined With Cognitive Training to Improve Complex Attention in Active Duty Service Members and Veterans With Mild TBI (Cognetric) PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training (RS-tDCS+) which has shown promise for improving complex attention in both healthy and clinical populations. RS-tDCS+ is a home-based, low-risk, … |
LARS HUNGERFORD; | 2025-11-12 |
| 184 | Using EMR Data and AI to Develop A Passive Digital Marker to Predict Postoperative Delirium PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: This study will be a pilot randomized controlled trial that will determine the effect of an indicator of delirium risk, which will be delivered either via a paper form or via the electronic medical record, on (1)postoperative delirium incidence; and (2)the development of long term cognitive decline and dementia. |
SANJAY MOHANTY; | 2026-02-12 |
| 185 | Evaluating The Feasibility of Utilizing A Novel Brain Activity Monitor in The Neurosciences Intensive Care Unit PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the clinical utility of Neurosteer’s brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients. The research team will be conducting a single-site study. The research team will enroll 100 patients admitted to the NSICU. 50 of these patients will have Acute Neurological Injuries (ANI) and the other 50 will not have an ANI. All enrolled patients will receive the intervention, … |
NEHA DANGAYACH; | 2025-07-01 |
| 186 | Brain Development in Young Children Following Mild Traumatic Brain Injury – Pilot Study PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: Concussions (also known as mild traumatic brain injury) are common in young children. In some children, they can lead to short- and long-term difficulties. However, our knowledge of the exact consequences of injuries on young children’s brains and behavior is limited. These consequences may be different in children under 6, as their brains are fragile and undergoing significant developmental changes. The aim of this study is to determine the extent to which a concussion sustained before the age of 6 years is associated with changes in young children’s brain structure, function and behaviours, using a brain imaging. In this study, … |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE FRANCE | 2026-03-05 |
| 187 | Phase 2 Randomized Controlled Trial of Sildenafil Citrate for Treatment of Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Traumatic Cerebral Vascular Injury (TCVI) is a common consequence of traumatic brain injury (TBI), including mild TBI (mTBI). TCVI is associated with poor recovery after TBI in animal models. TCVI can be measured non-invasively in humans, and therapies targeting TCVI are attractive candidates to ameliorate the consequences of TBI. Sildenafil potentiates nitric oxide (NO) dependent vasodilatation and is approved by the Food and Drug Administration (FDA) for the treatment of erectile dysfunction and primary pulmonary hypertension. In pre-clinical models of stroke, sildenafil improves cerebral blood flow (CBF), promotes, angiogenesis, … |
RAMON DIAZ-ARRASTIA; | 2025-12-10 |
| 188 | Intensive Physical Exercise Versus Standard Exercise During Rehabilitation of Patients With Traumatic Brain Injury – A Randomised Pilot and Feasibility Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The aim of this randomised multicentre clinical feasibility and pilot trial is to test if a sit-to-stand trial protocol is feasible regarding the increased intensity, trial recruitment, and completion of outcome data in patients with moderate to severe traumatic brain injury during the rehabilitation phase. For the trial to be feasible, all outcomes must be achieved. The primary hypothesis is that it is feasible to progressively increase the number of repetitions of sit-to-stand exercises in patients with moderate to severe traumatic brain injury admitted to a rehabilitation department during the intervention period. Furthermore, … |
CHRISTIAN RIBERHOLT; | 2026-01-31 |
| 189 | Dementia in Migrants Living in Italy: Promoting A Diversity-sensitive Clinical Approach and Provision of Care PF:6 Related Papers Related Patents Related Grants Related Experts Highlight: The number of older migrants with cognitive impairment and dementia living in Italy and attending national healthcare services is rapidly increasing. There is a need to develop diversity-sensitive policies and practices to include migrants and people with different cultural values in the public health response to dementia. |
MARCO CANEVELLI; | 2025-06-30 |
| 190 | External Lumbar Drainage to Abort Severe Traumatic IntraCranial Hypertension: A Phase 1 Randomized, Allocation-concealed, Open-label, Safety and Feasibility Clinical Trial PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this phase 1 randomized controlled safety and feasibility clinical trial are to determine the safety of external lumbar drainage (ELD) in select patients with severe Traumatic Brain Injury (TBI). The main questions it aims to answer are (i) if ELD is feasible and (ii) safe to perform in severe TBI patients who have radiological evidence of patent basal cisterns and midline shift \<5mm without increasing the risk of neurological worsening or cerebral herniation. All participants will receive routine usual care. The study group will additionally have ELD for cerebrospinal fluid (CSF) drainage. A comparison will be made between the usual treatment plus ELD (interventional) groups, and the usual treatment (control) groups on incidence rate of neurological worsening or cerebral herniation events, and whether total hours with raised intracranial pressure (ICP) are different. |
HALINDER MANGAT; | 2025-09-19 |
| 191 | Strengthening Neuro-Cognitive Skills for Success in School, Work and Beyond PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: For many Veterans, success in achieving goals at work, school and in other aspects of life are top priorities. The abilities to regulate attention, remember key information, and stay calm and on track are fundamental to this success. Unfortunately, Veterans who have experienced a traumatic brain injury (TBI) often struggle with these very abilities, and a number of barriers can make it difficult for them to access the help Veterans need. Tele-rehabilitation has the potential to overcome some of these barriers and increase access to care, … |
ANTHONY J. W. CHEN; | 2025-11-17 |
| 192 | A Pragmatic Rehabilitation Intervention to Supplement Progressive Return to Activity Following Mild Traumatic Brain Injury in Service Members (SMs): The Active Rehab Study PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: The strategic objective of this research line is to examine improving short- and long-term outcomes for soldiers following mild traumatic brain injury (mTBI). The technical objectives are to: 1) conduct a Phase 1 quasi-experimental pragmatic trial testing the potential benefit of provider directed active rehabilitation therapies (Active Rehab) in accelerating return of injured soldiers back to active duty and improving cognitive and functional limitations following mTBI, … |
JOHNA K REGISTER-MIHALIK; | 2026-02-27 |
| 193 | Predictors of Mortality Among Patients With Head Trauma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Evaluate the usefulness of the APACHE II (Acute Physiology and Chronic Health Evaluation II), RTS (Revised trauma score), GCS (Glasgow Coma Scale) scores and various variables as age, sex, lab.data and complications in predicting mortality of patients with traumatic brain injury (TBI) in the intensive care unit (ICU). |
AYMAN MAHMOUD ALSAYES; | 2025-04-10 |
| 194 | A Comparative Analysis of Prognostic Factors for Functional Outcomes in Patients With Acute Subdural Hematoma PF:3 Related Papers Related Patents Related Grants Related Experts Highlight: Acute subdural hematoma (ASDH) is the most common intracranial traumatic lesion that requires surgical intervention. Although there is extensive published research on acute subdural, there remains uncertainty regarding mortality risk and functional outcomes for patients. This study aims to evaluate the effectiveness of contemporary scoring systems in different age groups of ASDH patients to predict functional outcomes. |
MICHAL SOTÁK; | 2025-11-19 |
| 195 | Transcranial Ultrasound and Transcranial Doppler in Diagnosis and Detection of Outcome in Infants With Neurological Diseases PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: To evaluate the accuracy of transcranial ultrasound in detection of brain pathology in infants with neurological diseases and value of transcranial Doppler in evaluation of intracerebral blood flow in comparison with other radiological modalities according to available imaging. |
ESRAA SAMI ABDELRAHMAN KHALIFA; | 2025-07-30 |
| 196 | Investigation of The Effectiveness of Obesity in The Development of Chronic Headache After Traumatic Brain Injury PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The relationship between obesity and the development of chronic headache after traumatic brain injury will be investigated. |
HATİCE TOPRAK; | 2025-10-01 |
| 197 | Multicenter, Double-blind, Randomized, Placebo Controlled, Study to Assess The Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301), in Patients With Severe Traumatic Brain Injury (TBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The main goal of this clinical trial is to check if the treatment is safe and well-tolerated. Researchers will compare the MR-301 active drug group with the placebo group to evaluate the safety and tolerability of the drug. Other measurements include assessing the patient’s overall outcome, neurological responses, time spent in the intensive care unit, time in the hospital, and mortality. Participants will receive either MR-301 BID IV dosing or a matching placebo for a total of 3 weeks. |
SHINKEI THERAPEUTICS | 2025-07-15 |
| 198 | A Randomized, Double-blind, Placebo Controlled Study of The Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury (TBI) PF:2 Related Papers Related Patents Related Grants Related Experts Highlight: The goal of this clinical trial is to test the safety of the drug Angiotensin (1-7) and learn whether it works well as a treatment in people who have suffered a moderate to severe traumatic brain injury (TBI). The main questions this trial aims to answer are: * Is Angiotensin (1-7) safe? * Does Angiotensin (1-7) improve mental functioning and reduce physical signs of brain damage in people who have suffered a moderate to severe TBI? Participants will: * Complete 21 days of study treatment consisting of a once-daily injection. * Provide blood samples. * Undergo two magnetic resonance imaging (MRI) scans of the brain. * Complete specific tasks and questionnaires that allow researchers to evaluate the participant’s brain and psychological functioning. Researchers will compare three groups: two groups that receive different doses of Angiotensin (1-7) and one group that receives a look-alike treatment with no active drug. This will allow researchers to see if the drug has any negative effects and whether it improves mental functioning and physical signs of brain damage after a TBI. |
BELLAL JOSEPH; | 2025-07-31 |
| 199 | Using Functional Near-Infrared Spectroscopy (fNIRS) to Assess Neural Activity During A Virtual Reality Walking Intervention: A Feasibility Study Related Papers Related Patents Related Grants Related Experts Highlight: The purpose of this study is to evaluate the safety and feasibility of using a portable neuroimaging device called functional near-infrared spectroscopy (fNIRS) to successfully analyze fNIRS data in individuals with chronic TBI during treadmill training augmented with VR. |
CANDACE TEFERTILLER; | 2026-03-30 |
| 200 | Real-life Performance and Added Value of The VIDAS® TBI Blood Test in The Assessment of Mild Traumatic Brain Injury (mTBI), in Subjects With A Glasgow Coma Scale (GCS) Between 13-15 PF:4 Related Papers Related Patents Related Grants Related Experts Highlight: Decision Rules for an initial CT-scan in patients arriving to Emergency Department (ED) and presenting a mild traumatic brain injury could be optimized by the use of an objective parameter easily and rapidly measured. This may be the place for serum biomarkers providing a quick and accurate assessment. BioMérieux has now developed an automated assay for the measurement of serum Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase (UCH-L1), the VIDAS® TBI assay to fill out this unmet needs. The goal of the herein study is to generate real-world data and evidences to support the VIDAS® TBI performances. |
BIOMÉRIEUX | 2026-03-06 |